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Sample records for abnormal laboratory test

  1. Laboratory Tests

    MedlinePlus

    Laboratory tests check a sample of your blood, urine, or body tissues. A technician or your doctor ... compare your results to results from previous tests. Laboratory tests are often part of a routine checkup ...

  2. Spondylodiscitis after Cervical Nucleoplasty without Any Abnormal Laboratory Findings

    PubMed Central

    Lee, Seung Jun; Choi, Eun Joo

    2013-01-01

    Infective spondylodiscitis is a rare complication that can occur after interventional spinal procedures, of which symptoms are usually back pain and fever. Early diagnosis of infective spondylodiscitis is critical to start antibiotics and to improve prognosis. Laboratory examinations including complet blood cell count (CBC), erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) are conventional tools for the early detection of infectious spondylitis. However, we experienced infective spondylodiscitis after cervical nucleoplasty which did not display any laboratory abnormalities, but was diagnosed through an MRI. A patient with cervical disc herniation received nucleoplasty at C5/6 and C6/7. One month later, the patient complained of aggravated pain. There were neither signs of chill nor fever, and the laboratory results appeared normal. However, the MRI findings were compatible with infectious spondylodiscitis at the nucleoplasty site. In conclusion, infectious spondylodiscitis can develop after cervical nucleoplasty without any laboratory abnormalities. Therefore, an MRI should be taken when there is a clinical suspicion for infection in order to not miss complications after interventional procedures, even if the laboratory findings are normal. PMID:23614083

  3. Laboratory tests, interpretation, and use of resources

    PubMed Central

    Abbott, Marcia; Paulin, Heidi; Sidhu, Davinder; Naugler, Christopher

    2014-01-01

    Abstract Problem addressed The overuse of laboratory testing has increased rapidly and is contributing to the financial strain on the health care system in Canada. Moreover, a substantial proportion of ordered tests are unnecessary. In a search of all the Canadian family physician residency programs, none lists laboratory training as mandatory or as an optional elective in its curriculum. Objective of program To introduce family medicine residents to appropriate and efficient use of laboratory tests. Program description The program was run as a series of identical 4-hour small group sessions to facilitate discussion and laboratory tours. The curriculum focused on 7 key topics: problems associated with laboratory testing, sources of laboratory errors, definitions of normal and abnormal test results, appropriate use of laboratory requisition forms, laboratory quality assurance methods, laboratory collection processes, and costs of common laboratory tests. Residents were taken to a patient specimen collection site for a tour and introduction, followed by approximately 2 hours of didactic sessions, and ending with a tour of a large tertiary care testing facility. Conclusion The program was very well received by family medicine residents and resulted in a substantial increase in residents’ self-assessed knowledge of the 7 topics covered in the curriculum. It is hoped that this program will fill an important gap in residency training and support residents’ competency in the “selectivity” domain of training. PMID:24627400

  4. World of Forensic Laboratory Testing

    MedlinePlus

    ... Visit Global Sites Search Help? The World of Forensic Laboratory Testing Share this page: Was this page helpful? Overview | Forensic Pathology | Forensic Toxicology | Genetic Tests and DNA Typing | ...

  5. Terminology of developmental abnormalities in common laboratory mammals (version 1).

    PubMed

    Wise, L D; Beck, S L; Beltrame, D; Beyer, B K; Chahoud, I; Clark, R L; Clark, R; Druga, A M; Feuston, M H; Guittin, P; Henwood, S M; Kimmel, C A; Lindstrom, P; Palmer, A K; Petrere, J A; Solomon, H M; Yasuda, M; York, R G

    1997-04-01

    This paper presents the first version of an internationally-developed glossary of terms for structural developmental abnormalities in common laboratory animals. The glossary is put forward by the International Federation of Teratology Societies (IFTS) Committee on International Harmonization of Nomenclature in Developmental Toxicology, and represents considerable progress toward harmonization of terminology in this area. The purpose of this effort is to provide a common vocabulary that will reduce confusion and ambiguity in the description of developmental effects, particularly in submissions to regulatory agencies worldwide. The glossary contains a primary term or phrase, a definition of the abnormality, and notes, where appropriate. Selected synonyms or related terms, which reflect a similar or closely related concept, are noted. Nonpreferred terms are indicated where their usage may be incorrect. Modifying terms used repeatedly in the glossary (e.g., absent, branched) are listed and defined separately, instead of repeating their definitions for each observation. Syndrome names are generally excluded from the glossary, but are listed separately in an appendix. The glossary is organized into broad sections for external, visceral, and skeletal observations, then subdivided into regions, structures, or organs in a general overall head to tail sequence. Numbering is sequential, and not in any regional or hierarchical order. Uses and misuses of the glossary are discussed. Comments, questions, suggestions, and additions from practitioners in the field of developmental toxicology are welcomed on the organization of the glossary as well as on the specific terms and definitions. Updates of the glossary are planned based on the comments received.

  6. Laboratory Tests in the Rheumatic Disease

    PubMed Central

    Aaron, S.L.

    1988-01-01

    Because the pathophysiologic relationship between laboratory and clinical abnormalities in many of the rheumatologic diseases is still not clearly understood, the use of the investigations dealt with in this article is based only upon statistics. The interpretation of these tests is therefore highly dependent on the result of the initial clinical assessment. Having accepted this limitation, however, the rheumatologist has available a number of powerful tools which may be used to diagnose, classify, or prognosticate. ImagesFigure 1 PMID:21253052

  7. [Laboratory accreditation and proficiency testing].

    PubMed

    Kuwa, Katsuhiko

    2003-05-01

    ISO/TC 212 covering clinical laboratory testing and in vitro diagnostic test systems will issue the international standard for medical laboratory quality and competence requirements, ISO 15189. This standard is based on the ISO/IEC 17025, general requirements for competence of testing and calibration laboratories and ISO 9001, quality management systems-requirements. Clinical laboratory services are essential to patient care and therefore should be available to meet the needs of all patients and clinical personnel responsible for human health care. If a laboratory seeks accreditation, it should select an accreditation body that operates according to this international standard and in a manner which takes into account the particular requirements of clinical laboratories. Proficiency testing should be available to evaluate the calibration laboratories and reference measurement laboratories in clinical medicine. Reference measurement procedures should be of precise and the analytical principle of measurement applied should ensure reliability. We should be prepared to establish a quality management system and proficiency testing in clinical laboratories.

  8. Misleading biochemical laboratory test results

    PubMed Central

    Nanji, Amin A.

    1984-01-01

    This article reviews the general and specific factors that interfere with the performance of common biochemical laboratory tests and the interpretation of their results. The clinical status of the patient, drug interactions, and in-vivo and in-vitro biochemical interactions and changes may alter the results obtained from biochemical analysis of blood constituents. Failure to recognize invalid laboratory test results may lead to injudicious and dangerous management of patients. PMID:6375845

  9. Abnormal Cervical Cancer Screening Test Results

    MedlinePlus

    ... Preferred— Repeat Pap test in 12 months Acceptable— Reflex HPV test ‡ Preferred— Reflex HPV test ‡ Acceptable— Repeat Pap test in 12 ... of HPV type 16 and HPV type 18 ‡ Reflex HPV test: A test for the presence of ...

  10. Test Laboratory Facilities and Capabilities

    NASA Technical Reports Server (NTRS)

    Hamilton, Jeff

    2004-01-01

    The Test Laboratory at NASA's Marshall Space Flight Center, located inside the boundaries of 40,000 acre Redstone Arsenal military reservation, has over 50 test facilities across 400+ acres, many inside an additional secure, fenced area. About 150 Government and 250 contractor personnel operate test facilities capable of all types of propulsion and structural testing, from small components to engine systems and structural strength/dynamic and environmental testing. We have tremendous engineering expertise in research, evaluation, analysis, design and development, and test of space transportation systems, subsystems, and components.

  11. Mutant laboratory mice with abnormalities in pigmentation: annotated tables.

    PubMed

    Nakamura, Motonobu; Tobin, Desmond J; Richards-Smith, Beverly; Sundberg, John P; Paus, Ralf

    2002-01-01

    Mammalian pigment cell research has recently entered a phase of significantly increased activity due largely to the exploitation of the many mutant mouse stocks that are coming on stream. Numerous transgenic, targeted mutagenesis (so-called 'knockouts'), conditional (so-called 'gene switch') and spontaneous mutant mice develop abnormal coat color phenotypes. The number of mice that exhibit such abnormalities is increasing exponentially as genetic engineering methods become routine. Since defined abnormalities in such mutant mice provide important clues to the as yet often poorly understood functional roles of many gene products, this overview includes a corresponding, annotated table of mutant mice with pigmentation alterations. These range from early developmental defects via a large array of coat color abnormalities to a melanoma metastasis model. This overview should provide helpful pointers to investigators who are looking for mouse models to explore or to compare functional activities of genes of interest and for comparing coat color phenotypes of spontaneous or genetically engineered mouse mutants with novel ones. Secondly, this review includes a table of mouse models of specific human diseases with genetically defined pigmentation abnormalities. In summary, this annotated table should serve as a useful reference for anyone interested in the molecular controls of pigmentation.

  12. 3. VIEW LOOKING NORTH, COMPONENTS TEST LABORATORY, DYNAMIC TEST FACILITY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. VIEW LOOKING NORTH, COMPONENTS TEST LABORATORY, DYNAMIC TEST FACILITY (SATURN V IN BACKGROUND). - Marshall Space Flight Center, East Test Area, Components Test Laboratory, Huntsville, Madison County, AL

  13. Laboratory testing for prescription opioids.

    PubMed

    Milone, Michael C

    2012-12-01

    Opioid analgesic misuse has risen significantly over the past two decades, and these drugs now represent the most commonly abused class of prescription medications. They are a major cause of poisoning deaths in the USA exceeding heroin and cocaine. Laboratory testing plays a role in the detection of opioid misuse and the evaluation of patients with opioid intoxication. Laboratories use both immunoassay and chromatographic methods (e.g., liquid chromatography with mass spectrometry detection), often in combination, to yield high detection sensitivity and drug specificity. Testing methods for opioids originated in the workplace-testing arena and focused on detection of illicit heroin use. Analysis for a wide range of opioids is now required in the context of the prescription opioid epidemic. Testing methods have also been primarily based upon urine screening; however, methods for analyzing alternative samples such as saliva, sweat, and hair are available. Application of testing to monitor prescription opioid drug therapy is an increasingly important use of drug testing, and this area of testing introduces new interpretative challenges. In particular, drug metabolism may transform one clinically available opioid into another. The sensitivity of testing methods also varies considerably across the spectrum of opioid drugs. An understanding of opioid metabolism and method sensitivity towards different opioid drugs is therefore essential to effective use of these tests. Improved testing algorithms and more research into the effective use of drug testing in the clinical setting, particularly in pain medicine and substance abuse, are needed.

  14. Laboratory test system. Final report

    SciTech Connect

    Asher, G.L.

    1980-03-01

    This project was initiated to develop a laboratory test capability for evaluating new and existing digital product designs. In recent years, Bendix Kansas City has become more active in syppling early development hardware to the design laboratories for evaluation. Because of the more complex electronic designs being used in new components, more highly automated test systems are needed to evaluate development hardware. To meet this requirement, a universal test system was developed to provide both basic test capabilities and flexibility to adapt easily to specific product applications. This laboratory evaluation system will reduce the need to develop complex dedicated test systems for each new product design, while still providing the benefits of an automated system. A special purpose interface chassis was designed and fabricated to permit a standardized interface between the test system and the product application. Connector assignments by system functions provide convenience and function isolation. Standard cables were used to reduce the need for special purpose hardware. Electrical testing of a developmental electronics assembly demonstrated the adaptability of this system for a typical product application. Both the interface hardware and the software were developed for this application.

  15. Real-Time Microbiology Laboratory Surveillance System to Detect Abnormal Events and Emerging Infections, Marseille, France.

    PubMed

    Abat, Cédric; Chaudet, Hervé; Colson, Philippe; Rolain, Jean-Marc; Raoult, Didier

    2015-08-01

    Infectious diseases are a major threat to humanity, and accurate surveillance is essential. We describe how to implement a laboratory data-based surveillance system in a clinical microbiology laboratory. Two historical Microsoft Excel databases were implemented. The data were then sorted and used to execute the following 2 surveillance systems in Excel: the Bacterial real-time Laboratory-based Surveillance System (BALYSES) for monitoring the number of patients infected with bacterial species isolated at least once in our laboratory during the study periodl and the Marseille Antibiotic Resistance Surveillance System (MARSS), which surveys the primary β-lactam resistance phenotypes for 15 selected bacterial species. The first historical database contained 174,853 identifications of bacteria, and the second contained 12,062 results of antibiotic susceptibility testing. From May 21, 2013, through June 4, 2014, BALYSES and MARSS enabled the detection of 52 abnormal events for 24 bacterial species, leading to 19 official reports. This system is currently being refined and improved.

  16. Real-Time Microbiology Laboratory Surveillance System to Detect Abnormal Events and Emerging Infections, Marseille, France

    PubMed Central

    Abat, Cédric; Chaudet, Hervé; Colson, Philippe; Rolain, Jean-Marc

    2015-01-01

    Infectious diseases are a major threat to humanity, and accurate surveillance is essential. We describe how to implement a laboratory data–based surveillance system in a clinical microbiology laboratory. Two historical Microsoft Excel databases were implemented. The data were then sorted and used to execute the following 2 surveillance systems in Excel: the Bacterial real-time Laboratory-based Surveillance System (BALYSES) for monitoring the number of patients infected with bacterial species isolated at least once in our laboratory during the study periodl and the Marseille Antibiotic Resistance Surveillance System (MARSS), which surveys the primary β-lactam resistance phenotypes for 15 selected bacterial species. The first historical database contained 174,853 identifications of bacteria, and the second contained 12,062 results of antibiotic susceptibility testing. From May 21, 2013, through June 4, 2014, BALYSES and MARSS enabled the detection of 52 abnormal events for 24 bacterial species, leading to 19 official reports. This system is currently being refined and improved. PMID:26196165

  17. Prevalence of respiratory abnormalities and pneumoconiosis in dental laboratory technicians.

    PubMed

    Ozdemir Doğan, Derya; Ozdemir, Ali Kemal; Polat, Nilüfer Tülin; Dal, Uğur; Gümüş, Cesur; Akkurt, Ibrahim

    2010-01-01

    A preventable occupational disease, pneumoconiosis that is often widespread on to a very kind of quartz, carbon and metal dust exposed work place.The data for the prevalence of pneumoconiosis and respiratory findings among dental laboratory technician is insufficient. The aim of this study is to determine the prevalence of pneumoconiosis and respiratory findings among dental laboratory technicians, working in province of Sivas. For this reason all the dental technicians (except 2, totally 36) participated in the study. A questionnaire which contains demographic characteristics, work conditions and symptoms were applied to all participants. Also spirometric measurements and chest x-rays were performed. The x-rays of dental technicians were evaluated by a radiologist and a chest disease specialist according to the ILO-2000 classification of pneumoconiosis. Almost half of the all participants have dyspnea and phlegm expectoration. The prevalence of pneumoconiosis was 5 (13.8%) among 36 dental technicians. There were no statistically significant differences between two groups with regard to respiratory symptoms. Values of lung function parameters of the dental technician group were not significantly different from those of control group except FEV(1). In conclusion, dental laboratory technicians are at significant risks for occupational respiratory diseases so the primary prevention rules are essential for these work places.

  18. Educational ultrasound nondestructive testing laboratory.

    PubMed

    Genis, Vladimir; Zagorski, Michael

    2008-09-01

    The ultrasound nondestructive evaluation (NDE) of materials course was developed for applied engineering technology students at Drexel University's Goodwin College of Professional Studies. This three-credit, hands-on laboratory course consists of two parts: the first part with an emphasis on the foundations of NDE, and the second part during which ultrasound NDE techniques are utilized in the evaluation of parts and materials. NDE applications are presented and applied through real-life problems, including calibration and use of the latest ultrasonic testing instrumentation. The students learn engineering and physical principles of measurements of sound velocity in different materials, attenuation coefficients, material thickness, and location and dimensions of discontinuities in various materials, such as holes, cracks, and flaws. The work in the laboratory enhances the fundamentals taught during classroom sessions. This course will ultimately result in improvements in the educational process ["The greater expectations," national panel report, http://www.greaterexpectations.org (last viewed February, 2008); R. M. Felder and R. Brent "The intellectual development of Science and Engineering Students. Part 2: Teaching to promote growth," J. Eng. Educ. 93, 279-291 (2004)] since industry is becoming increasingly reliant on the effective application of NDE technology and the demand on NDE specialists is increasing. NDE curriculum was designed to fulfill levels I and II NDE in theory and training requirements, according to American Society for Nondestructive Testing, OH, Recommended Practice No. SNT-TC-1A (2006).

  19. CERTS Microgrid Laboratory Test Bed

    SciTech Connect

    Lasseter, R. H.; Eto, J. H.; Schenkman, B.; Stevens, J.; Volkmmer, H.; Klapp, D.; Linton, E.; Hurtado, H.; Roy, J.

    2010-06-08

    CERTS Microgrid concept captures the emerging potential of distributed generation using a system approach. CERTS views generation and associated loads as a subsystem or a 'microgrid'. The sources can operate in parallel to the grid or can operate in island, providing UPS services. The system can disconnect from the utility during large events (i.e. faults, voltage collapses), but may also intentionally disconnect when the quality of power from the grid falls below certain standards. CERTS Microgrid concepts were demonstrated at a full-scale test bed built near Columbus, Ohio and operated by American Electric Power. The testing fully confirmed earlier research that had been conducted initially through analytical simulations, then through laboratory emulations, and finally through factory acceptance testing of individual microgrid components. The islanding and resynchronization method met all Institute of Electrical and Electronics Engineers Standard 1547 and power quality requirements. The electrical protection system was able to distinguish between normal and faulted operation. The controls were found to be robust under all conditions, including difficult motor starts and high impedance faults.

  20. Harmonization of Clinical Laboratory Test Results.

    PubMed

    2016-02-01

    Clinical laboratory testing is now a global activity with laboratories no longer working in isolation but as regional and national networks, and often at international levels. We now have all of the electronic gadgetry via internet technology at our fingertips to rapidly and accurately measure and report on laboratory testing but are our test results harmonized?

  1. CERTS Microgrid Laboratory Test Bed

    SciTech Connect

    Eto, Joe; Lasseter, Robert; Schenkman, Ben; Stevens, John; Klapp, Dave; Volkommer, Harry; Linton, Ed; Hurtado, Hector; Roy, Jean

    2009-06-18

    The objective of the CERTS Microgrid Test Bed project was to enhance the ease of integrating energy sources into a microgrid. The project accomplished this objective by developing and demonstrating three advanced techniques, collectively referred to as the CERTS Microgrid concept, that significantly reduce the level of custom field engineering needed to operate microgrids consisting of generating sources less than 100kW. The techniques comprising the CERTS Microgrid concept are: 1) a method for effecting automatic and seamless transitions between grid-connected and islanded modes of operation, islanding the microgrid's load from a disturbance, thereby maintaining a higher level of service, without impacting the integrity of the utility's electrical power grid; 2) an approach to electrical protection within a limited source microgrid that does not depend on high fault currents; and 3) a method for microgrid control that achieves voltage and frequency stability under islanded conditions without requiring high-speed communications between sources. These techniques were demonstrated at a full-scale test bed built near Columbus, Ohio and operated by American Electric Power. The testing fully confirmed earlier research that had been conducted initially through analytical simulations, then through laboratory emulations,and finally through factory acceptance testing of individual microgrid components. The islanding and resychronization method met all Institute of Electrical and Electronics Engineers Standard 1547 and power quality requirements. The electrical protection system was able to distinguish between normal and faulted operation. The controls were found to be robust under all conditions, including difficult motor starts and high impedance faults. The results from these tests are expected to lead to additional testing of enhancements to the basic techniques at the test bed to improve the business case for microgrid technologies, as well to field demonstrations

  2. Testing containment of laboratory hoods

    SciTech Connect

    Knutson, G.W.

    1987-06-01

    Laboratory fume hoods often do not adequately provide protection to a chemist or technician at the hood. The reason for failure of the hoods to perform adequately are varied and, in many instances, difficult to determine. In some cases, the laboratory hood manufacturer has provided equipment that does not reflect the state of art in controlling laboratory exposures. In other cases, the architect or engineer has disregarded the function of the hood thus the design of the installation is faulty and the hood will not work. The contractor may have installed the system so poorly that it will not adequately function. Finally, the chemist or technician may misuse the hood, causing poor performance. This paper considers a method of evaluating the performance of laboratory fume hoods. Using the method, the paper examines several instances where the laboratory fume hood performed inadequately, quantifies the performance and identifies the cause of poor performance.

  3. Clinical disease and laboratory abnormalities in free-ranging desert tortoises in California (1990-1995)

    USGS Publications Warehouse

    Christopher, Mary M.; Berry, Kristin H.; Henen, Brian T.; Nagy, Kenneth A.

    2003-01-01

    Desert tortoise (Gopherus agassizii) populations have experienced precipitous declines resulting from the cumulative impact of habitat loss and human and disease-related mortality. Diagnosis of disease in live, free-ranging tortoises is facilitated by evaluation of clinical signs and laboratory test results but may be complicated by seasonal and environmental effects. The goals of this study were: 1) to describe and monitor clinical and laboratory signs of disease in adult, free-ranging desert tortoises at three sites in the Mojave Desert of California (USA) between October 1990 and October 1995; 2) to evaluate associations between clinical signs and hematologic, biochemical, serologic, and microbiologic test results; 3) to characterize disease patterns by site, season, and sex; and 4) to assess the utility of diagnostic tests in predicting morbidity and mortality. Venous blood samples were obtained four times per year from tortoises of both sexes at the Desert Tortoise Research Natural Area (DTNA), Goffs/Fenner Valley, and Ivanpah Valley. Tortoises were given a physical examination, and clinical abnormalities were graded by type and severity. Of 108 tortoises, 68.5% had clinical signs of upper respiratory tract disease consistent with mycoplasmosis at least once during the study period. In addition, 48.1% developed moderate to severe shell lesions consistent with cutaneous dyskeratosis. Ulcerated or plaque-like oral lesions were noted on single occasions in 23% of tortoises at Goffs and 6% of tortoises at Ivanpah. Tortoises with oral lesions were significantly more likely than tortoises without lesions to have positive nasal cultures for Mycoplasma agassizii(P=0.001) and to be dehydrated (P=0.0007). Nine tortoises had marked azotemia (blood urea nitrogen [BUN] >100 mg/dl) or persistent azotemia (BUN 63–76 mg/dl); four of these died, three of which had necropsy confirmation of urinary tract disease. Laboratory tests had low sensitivity but high specificity in

  4. Postirradiation Testing Laboratory (327 Building)

    SciTech Connect

    Kammenzind, D.E.

    1997-05-28

    A Standards/Requirements Identification Document (S/RID) is the total list of the Environment, Safety and Health (ES and H) requirements to be implemented by a site, facility, or activity. These requirements are appropriate to the life cycle phase to achieve an adequate level of protection for worker and public health and safety, and the environment during design, construction, operation, decontamination and decommissioning, and environmental restoration. S/RlDs are living documents, to be revised appropriately based on change in the site`s or facility`s mission or configuration, a change in the facility`s life cycle phase, or a change to the applicable standards/requirements. S/RIDs encompass health and safety, environmental, and safety related safeguards and security (S and S) standards/requirements related to the functional areas listed in the US Department of Energy (DOE) Environment, Safety and Health Configuration Guide. The Fluor Daniel Hanford (FDH) Contract S/RID contains standards/requirements, applicable to FDH and FDH subcontractors, necessary for safe operation of Project Hanford Management Contract (PHMC) facilities, that are not the direct responsibility of the facility manager (e.g., a site-wide fire department). Facility S/RIDs contain standards/requirements applicable to a specific facility that are the direct responsibility of the facility manager. S/RlDs are prepared by those responsible for managing the operation of facilities or the conduct of activities that present a potential threat to the health and safety of workers, public, or the environment, including: Hazard Category 1 and 2 nuclear facilities and activities, as defined in DOE 5480.23. Selected Hazard Category 3 nuclear, and Low Hazard non-nuclear facilities and activities, as agreed upon by RL. The Postirradiation Testing Laboratory (PTL) S/RID contains standards/ requirements that are necessary for safe operation of the PTL facility, and other building/areas that are the direct

  5. Putting New Laboratory Tests Into Practice

    MedlinePlus

    ... products and services. Advertising & Sponsorship: Policy | Opportunities Putting New Laboratory Tests into Practice Share this page: Was this page helpful? Introduction | Why develop new tests | Regulation | Gaining acceptance | Conclusion | Sources Overview This ...

  6. 21 CFR 640.67 - Laboratory tests.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... ADDITIONAL STANDARDS FOR HUMAN BLOOD AND BLOOD PRODUCTS Source Plasma § 640.67 Laboratory tests. Each unit of Source Plasma shall be tested for evidence of infection due to communicable disease agents as...

  7. 21 CFR 640.67 - Laboratory tests.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... ADDITIONAL STANDARDS FOR HUMAN BLOOD AND BLOOD PRODUCTS Source Plasma § 640.67 Laboratory tests. Each unit of Source Plasma shall be tested for evidence of infection due to communicable disease agents as...

  8. 21 CFR 640.67 - Laboratory tests.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... ADDITIONAL STANDARDS FOR HUMAN BLOOD AND BLOOD PRODUCTS Source Plasma § 640.67 Laboratory tests. Each unit of Source Plasma shall be tested for evidence of infection due to communicable disease agents as...

  9. 21 CFR 640.67 - Laboratory tests.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... ADDITIONAL STANDARDS FOR HUMAN BLOOD AND BLOOD PRODUCTS Source Plasma § 640.67 Laboratory tests. Each unit of Source Plasma shall be tested for evidence of infection due to communicable disease agents as...

  10. 21 CFR 640.67 - Laboratory tests.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... ADDITIONAL STANDARDS FOR HUMAN BLOOD AND BLOOD PRODUCTS Source Plasma § 640.67 Laboratory tests. Each unit of Source Plasma shall be tested for evidence of infection due to communicable disease agents as...

  11. Laboratory Performance Testing of Residential Dehumidifiers (Presentation)

    SciTech Connect

    Winkler, J.

    2012-03-01

    Six residential vapor compression cycle dehumidifiers spanning the available range of capacities and efficiencies were tested in the National Renewable Energy Laboratory's Heating, Ventilating, and Air-Conditioning Systems Laboratory. Each was tested under a wide range of indoor air conditions to facilitate the development of performance curves for use in whole-building simulation tools.

  12. Laboratory Soils Testing. Change 2

    DTIC Science & Technology

    1986-08-20

    7. PLASTICITY INDEX ...................... 111-20 8. REPORT .............................. 111-2 0 9. PREPARING CLAY SHALE MATERIAL FOR TESTING...V-8 4. COMBINED ANALYSIS & . ,,,,,,, v-21 5. PROCEDURES FOR PREPARING CLAY i . , SHALE MATERIAL . * , , , a , a , , , , V-24 6. POSSIBLE ERRORS...XII- 7 6. COMPUTATIONS ................. XII.-1 7. POSSIBLE ERRORS . .1 1 XII-12 * APPENDIX XIIA: MODIFIED PROVIDENCE VIBRATED DENSITY TEST

  13. How Reliable Is Laboratory Testing?

    MedlinePlus

    ... page: Was this page helpful? Overview | Key Concepts | Quality Control | Role of Testing | Conclusion | Sources What are the ... but is constantly monitored for reliability through comprehensive quality control and quality assurance procedures. Therefore, when your blood ...

  14. NASA White Sands Test Facility Remote Hypervelocity Test Laboratory

    NASA Video Gallery

    Tour the NASA White Sands Test Facility's Remote Hypervelocity Test Laboratory in Las Cruces, New Mexico. To learn more about White Sands Test Facility, go to http://www.nasa.gov/centers/wstf/home/...

  15. "Certified" Laboratory Practitioners and the Accuracy of Laboratory Test Results.

    ERIC Educational Resources Information Center

    Boe, Gerard P.; Fidler, James R.

    1988-01-01

    An attempt to replicate a study of the accuracy of test results of medical laboratories was unsuccessful. Limitations of the obtained data prevented the research from having satisfactory internal validity, so no formal report was published. External validity of the study was also limited because the systematic random sample of 78 licensed…

  16. Crime Laboratory Proficiency Testing Research Program.

    ERIC Educational Resources Information Center

    Peterson, Joseph L.; And Others

    A three-year research effort was conducted to design a crime laboratory proficiency testing program encompassing the United States. The objectives were to: (1) determine the feasibility of preparation and distribution of different classes of physical evidence; (2) assess the accuracy of criminalistics laboratories in the processing of selected…

  17. Laboratory tests and compliance of dermatologic outpatients

    PubMed Central

    Kim, Jaehwan

    2013-01-01

    Laboratory tests, including blood tests and urine analysis, are frequently performed in the dermatology outpatient clinic, but doctors often do not consider the cognitive or psychological effect of the examinations. Based on terror management theory, we hypothesized that performing laboratory tests increases the patient’s fear of mortality, and therefore has a positive effect on the patient’s attitude toward the doctor’s recommendations and willingness to accept them. The study employed a single factor between-subjects design, using a questionnaire completed by the patients. One group consisted of patients who had undergone laboratory tests 1 week before the survey, and the other group consisted of patients who had not undergone a laboratory test. Although the differences between two groups were not statistically significant, the patients who had laboratory tests had tendency to show even lower positive attitude toward the doctor’s recommendations and less intention to follow the recommendations. In contrast to our hypothesis, performing laboratory tests does not subliminally increase patients’ fears or anxieties about their disease or their compliance with doctors’ recommendations. PMID:24555101

  18. CERTS Microgrid Laboratory Test Bed

    SciTech Connect

    ETO, J.; LASSETER, R.; SCHENKMAN, B.; STEVENS, J.; KLAPP, D.; VOLKOMMER, H.; LINTON, E.; HURTADO, H.; ROY, J.

    2010-06-08

    The objective of the CERTS Microgrid Test Bed project was to enhance the ease of integrating energy sources into a microgrid. The project accomplished this objective by developing and demonstrating three advanced techniques, collectively referred to as the CERTS Microgrid concept, that significantly reduce the level of custom field engineering needed to operate microgrids consisting of generating sources less than 100kW. The techniques comprising the CERTS Microgrid concept are: 1 a method for effecting automatic and seamless transitions between grid-connected and islanded modes of operation, islanding the microgrid's load from a disturbance, thereby maintaining a higher level of service, without impacting the integrity of the utility's electrical power grid; 2 an approach to electrical protection within a limited source microgrid that does not depend on high fault currents; and 3 a method for microgrid control that achieves voltage and frequency stability under islanded conditions without requiring high-speed communications between sources.

  19. Antinuclear antibody testing: discordance between commercial laboratories.

    PubMed

    Abeles, Aryeh M; Gomez-Ramirez, Manuel; Abeles, Micha; Honiden, Shyoko

    2016-07-01

    Antinuclear antibody (ANA) test results frequently affect the course of patients' evaluations, diagnosis, and treatment, but different laboratory centers may yield conflicting results. This study investigated the degree of agreement between laboratory results in a group of subjects who had ANA testing performed at two commercial laboratories. This was a chart review study, in which all ANA tests ordered by the authors from one commercial laboratory over a 4-year period were queried. Corresponding patient charts were reviewed, and if ANA testing had also been performed at the second commercial laboratory, subjects were entered into the study. The primary measurement was agreement between paired ANA results, and we performed sensitivity analysis using varying criteria defining agreement (criteria A to criteria D [strictest to most lenient definition of agreement]). Other data captured included relevant data obtained through the course of evaluation (e.g., presenting complaints, exam findings, other laboratory data) and final diagnoses. Of 101 paired ANA tests, there was 18 % agreement according to the strictest criteria and 42 % according to the most lenient. Of the seven subjects with ANA-associated rheumatic disease, none of the paired tests were in agreement according to criteria A (two agreed according to criteria D). Our findings demonstrate poor agreement between paired ANA tests performed at two commercial laboratories. The low level of agreement may have far-reaching clinical implications. Specifically, this finding calls into question the reliability of ANA testing as it is currently performed and suggests that results may in part depend upon the laboratory center to which patients are referred.

  20. Mars Science Laboratory Spacecraft Assembled for Testing

    NASA Technical Reports Server (NTRS)

    2008-01-01

    The major components of NASA's Mars Science Laboratory spacecraft cruise stage atop the aeroshell, which has the descent stage and rover inside were connected together in October 2008 for several weeks of system testing, including simulation of launch vibrations and deep-space environmental conditions.

    These components will be taken apart again, for further work on each of them, after the environmental testing. The Mars Science Laboratory spacecraft is being assembled and tested for launch in 2011.

    This image was taken inside the Spacecraft Assembly Facility at NASA's Jet Propulsion Laboratory, Pasadena, Calif., which manages the Mars Science Laboratory Project for the NASA Science Mission Directorate, Washington. JPL is a division of the California Institute of Technology.

  1. Hereditary red cell membrane disorders and laboratory diagnostic testing.

    PubMed

    King, M-J; Zanella, A

    2013-06-01

    This overview describes two groups of nonimmune hereditary hemolytic anemias caused by defects in membrane proteins located in distinct layers of the red cell membrane. Hereditary spherocytosis (HS), hereditary elliptocytosis (HE), and hereditary pyropoikilocytosis (HPP) represent disorders of the red cell cytoskeleton. Hereditary stomatocytoses represents disorders of cation permeability in the red cell membrane. The current laboratory screening tests for HS are the osmotic fragility test, acid glycerol lysis time test (AGLT), cryohemolysis test, and eosin-5'-maleimide (EMA)-binding test. For atypical HS, SDS-polyacrylamide gel electrophoresis of erythrocyte membrane proteins is carried out to confirm the diagnosis. The diagnosis of HE/HPP is based on abnormal red cell morphology and the detection of protein 4.1R deficiency or spectrin variants using gel electrophoresis. None of screening tests can detect all HS cases. Some testing centers (a survey of 25 laboratories) use a combination of tests (e.g., AGLT and EMA). No specific screening test for hereditary stomatocytoses is available. The preliminary diagnosis is based on presenting a compensated hemolytic anemia, macrocytosis, and a temperature or time dependent pseudohyperkalemia in some patients. Both the EMA-binding test and the osmotic fragility test may help in differential diagnosis of HS and hereditary stomatocytosis.

  2. 10 CFR 431.18 - Testing laboratories.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 3 2013-01-01 2013-01-01 false Testing laboratories. 431.18 Section 431.18 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ENERGY EFFICIENCY PROGRAM FOR CERTAIN COMMERCIAL AND INDUSTRIAL EQUIPMENT Electric Motors Test Procedures, Materials Incorporated and Methods of Determining...

  3. 10 CFR 431.18 - Testing laboratories.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Testing laboratories. 431.18 Section 431.18 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ENERGY EFFICIENCY PROGRAM FOR CERTAIN COMMERCIAL AND INDUSTRIAL EQUIPMENT Electric Motors Test Procedures, Materials Incorporated and Methods of Determining...

  4. 10 CFR 431.18 - Testing laboratories.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 3 2012-01-01 2012-01-01 false Testing laboratories. 431.18 Section 431.18 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ENERGY EFFICIENCY PROGRAM FOR CERTAIN COMMERCIAL AND INDUSTRIAL EQUIPMENT Electric Motors Test Procedures, Materials Incorporated and Methods of Determining...

  5. 10 CFR 431.18 - Testing laboratories.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 3 2011-01-01 2011-01-01 false Testing laboratories. 431.18 Section 431.18 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ENERGY EFFICIENCY PROGRAM FOR CERTAIN COMMERCIAL AND INDUSTRIAL EQUIPMENT Electric Motors Test Procedures, Materials Incorporated and Methods of Determining...

  6. 10 CFR 431.18 - Testing laboratories.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 3 2014-01-01 2014-01-01 false Testing laboratories. 431.18 Section 431.18 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ENERGY EFFICIENCY PROGRAM FOR CERTAIN COMMERCIAL AND INDUSTRIAL EQUIPMENT Electric Motors Test Procedures, Materials Incorporated and Methods of Determining...

  7. Estimating personalized risk ranking using laboratory test and medical knowledge (UMLS).

    PubMed

    Patil, Meru A; Bhaumik, Sandip; Paul, Soubhik; Bissoyi, Swarupananda; Roy, Raj; Ryu, Seungwoo

    2013-01-01

    In this paper, we introduce a Concept Graph Engine (CG-Engine) that generates patient specific personalized disease ranking based on the laboratory test data. CG-Engine uses the Unified Medical Language System database as medical knowledge base. The CG-Engine consists of two concepts namely, a concept graph and its attributes. The concept graph is a two level tree that starts at a laboratory test root node and ends at a disease node. The attributes of concept graph are: Relation types, Semantic types, Number of Sources and Symmetric Information between nodes. These attributes are used to compute the weight between laboratory tests and diseases. The personalized disease ranking is created by aggregating the weights of all the paths connecting between a particular disease and contributing abnormal laboratory tests. The clinical application of CG-Engine improves physician's throughput as it provides the snapshot view of abnormal laboratory tests as well as a personalized disease ranking.

  8. Identification of an abnormal beryllium lymphocyte proliferation test.

    PubMed

    Frome, Edward L; Newman, Lee S; Cragle, Donna L; Colyer, Shirley P; Wambach, Paul F

    2003-02-01

    The potential hazards from exposure to beryllium or beryllium compounds in the workplace were first reported in the 1930s. The tritiated thymidine beryllium lymphocyte proliferation test (BeLPT) is an in vitro blood test that is widely used to screen beryllium exposed workers in the nuclear industry for sensitivity to beryllium. The clinical significance of the BeLPT was described and a standard protocol was developed in the late 1980s. Cell proliferation is measured by the incorporation of tritiated thymidine into dividing cells on two culture dates and using three concentrations of beryllium sulfate. Results are expressed as a 'stimulation index' (SI) which is the ratio of the amount of tritiated thymidine (measured by beta counts) in the simulated cells divided by the counts for the unstimulated cells on the same culture day. Several statistical methods for use in the routine analysis of the BeLPT were proposed in the early 1990s. The least absolute values (LAV) method was recommended for routine analysis of the BeLPT. This report further evaluates the LAV method using new data, and proposes a new method for identification of an abnormal or borderline test. This new statistical-biological positive (SBP) method reflects the clinical judgment that: (i) at least two SIs show a 'positive' response to beryllium; and (ii) that the maximum of the six SIs must exceed a cut-point that is determined from a reference data set of normal individuals whose blood has been tested by the same method in the same serum. The new data is from the Y-12 National Security Complex in Oak Ridge (Y-12) and consists of 1080 workers and 33 non-exposed control BeLPTs (all tested in the same serum). Graphical results are presented to explain the statistical method, and the new SBP method is applied to the Y-12 group. The true positive rate and specificity of the new method were estimated to be 86% and 97%, respectively. An electronic notebook that is accessible via the Internet was used in

  9. 222-S LABORATORY FUME HOOD TESTING STUDY

    SciTech Connect

    RUELAS, B.H.

    2007-03-26

    The 222-S Laboratory contains 155 active fume hoods that are used to support analytical work with radioactive and/or toxic materials. The performance of a fume hood was brought into question after employees detected odors in the work area while mixing chemicals within the subject fume hood. Following the event, testing of the fume hood was conducted to assess the performance of the fume hood. Based on observations from the testing, it was deemed appropriate to conduct performance evaluations of other fume hoods within the laboratory.

  10. Managing demand for laboratory tests: a laboratory toolkit.

    PubMed

    Fryer, Anthony A; Smellie, W Stuart A

    2013-01-01

    Healthcare budgets worldwide are facing increasing pressure to reduce costs and improve efficiency, while maintaining quality. Laboratory testing has not escaped this pressure, particularly since pathology investigations cost the National Health Service £2.5 billion per year. Indeed, the Carter Review, a UK Department of Health-commissioned review of pathology services in England, estimated that 20% of this could be saved by improving pathology services, despite an average annual increase of 8%-10% in workload. One area of increasing importance is managing the demands for pathology tests and reducing inappropriate requesting. The Carter Review estimated that 25% of pathology tests were unnecessary, representing a huge potential waste. Certainly, the large variability in levels of requesting between general practitioners suggests that inappropriate requesting is widespread. Unlocking the key to this variation and implementing measures to reduce inappropriate requesting would have major implications for patients and healthcare resources alike. This article reviews the approaches to demand management. Specifically, it aims to (a) define demand management and inappropriate requesting, (b) assess the drivers for demand management, (c) examine the various approaches used, illustrating the potential of electronic requesting and (d) provide a wider context. It will cover issues, such as educational approaches, information technology opportunities and challenges, vetting, duplicate request identification and management, the role of key performance indicators, profile composition and assessment of downstream impact of inappropriate requesting. Currently, many laboratories are exploring demand management using a plethora of disparate approaches. Hence, this review seeks to provide a 'toolkit' with the view to allowing laboratories to develop a standardised demand management strategy.

  11. [Laboratory tests for parasitic diseases in Israel].

    PubMed

    Marva, Esther; Grossman, Tamar

    2010-09-01

    Microscopic examination is still considered the gold standard for the diagnosis of parasitic diseases. In many clinical laboratories in hospitals and in health maintenance organizations ("Kupot Holim"), an excellent microscopic identification of parasites is performed. Microscopic examinations using wet mount preparations are performed for the detection of protozoan trophozoites and helmintic ova or larvae. Specific concentration techniques, including flotation and sedimentation procedures are further performed for the diagnosis of parasitic diseases. However, microscopic examinations are time-consuming, non-sensitive and not always reliable. Furthermore, the diagnosis of certain infections is not always possible by searching for the parasites in host tissues or excreta since risky invasive techniques might be necessary to locate the parasites. Detection of antibodies can be very useful as an indication for infection with a specific parasite, especially in individuals with no exposure to the parasite prior to recent travel in a disease-endemic area. In addition to serology, there are other tests of high sensitivity which can be integrated with microscopy, such as antigen detection in stool and blood samples as well as the use of other molecular diagnosis methods. There are two main laboratories in Israel where parasitic diagnosis is available by integration of microscopy, serology, antigen detection and molecular methods: The Reference Laboratory for Parasitology in Jerusalem at the Central Laboratories of the Ministry of Health (MOH) and the Laboratory of Parasitology at Soroka University Medical Center, Beer Sheva (SOR). There are also two special diagnostic units, one responsible for the identification of toxopLasma: Reference Laboratory for Toxoplasmosis, Public Health Laboratory, Ministry of Health, Tel Aviv (Tox), and the other for the identification of Leishmaniasis: Kuvin Center, Faculty of Medicine, Hebrew University of Jerusalem (Kuv). This article

  12. Distribution of Diseases Causing Liver Function Test Abnormality in Children and Natural Recovery Time of the Abnormal Liver Function

    PubMed Central

    2016-01-01

    Although liver function test abnormality is frequently noted in children, there is no report about the distribution of the etiology and natural recovery time of the abnormal liver function. From March 2005 to February 2014, clinical information was retrospectively collected from 559 children who had abnormal liver function and were hospitalized or visited the outpatient clinic at the Jeju National University Hospital. The etiology of abnormal liver function was classified into groups and the natural recovery time of abnormal liver function was analyzed. The etiological groups of 559 patients included ‘nonspecific hepatitis’ in 42 (7.5%), ‘infection’ in 323 (57.8%), ‘rheumatologic and autoimmune’ in 66 (11.8%), ‘nonalcoholic fatty liver disease’ in 57 (10.2%), ‘anatomic’ in 12 (2.1%), ‘toxic’ in 13 (2.1%), ‘metabolic’ in 8 (1.4%), ‘hematologic’ in 7 (1.3%), ‘hemodynamic’ in 4 (0.7%), and ‘others’ in 27 (4.8%). Among the ‘infection’ group (57.8%), the ‘viral infection in the respiratory tract’ subgroup, which had 111 patients (19.8%), was the most common. The natural recovery time of the abnormal liver function was 27 days (median) in ‘nonspecific hepatitis’, 13 days (median) in ‘viral respiratory tract disease’, 16 days (median) in ‘viral gastroenteritis’, 42 days (median) in ‘viral febrile illness”, and 7 days (median) in “Kawasaki disease”. The information on the natural recovery time of abnormal liver function may help the physician to perform good clinical consultation for patients and their parents. PMID:27709857

  13. 42 CFR 493.1441 - Condition: Laboratories performing high complexity testing; laboratory director.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... testing; laboratory director. 493.1441 Section 493.1441 Public Health CENTERS FOR MEDICARE & MEDICAID... REQUIREMENTS Personnel for Nonwaived Testing Laboratories Performing High Complexity Testing § 493.1441 Condition: Laboratories performing high complexity testing; laboratory director. The laboratory must have...

  14. 7 CFR 75.43 - Laboratory testing.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 3 2013-01-01 2013-01-01 false Laboratory testing. 75.43 Section 75.43 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards... AND CERTIFICATION OF QUALITY OF AGRICULTURAL AND VEGETABLE SEEDS Fees and Charges § 75.43...

  15. 7 CFR 75.43 - Laboratory testing.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 3 2011-01-01 2011-01-01 false Laboratory testing. 75.43 Section 75.43 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards... AND CERTIFICATION OF QUALITY OF AGRICULTURAL AND VEGETABLE SEEDS Fees and Charges § 75.43...

  16. 7 CFR 75.43 - Laboratory testing.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 3 2012-01-01 2012-01-01 false Laboratory testing. 75.43 Section 75.43 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards... AND CERTIFICATION OF QUALITY OF AGRICULTURAL AND VEGETABLE SEEDS Fees and Charges § 75.43...

  17. 7 CFR 75.43 - Laboratory testing.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Laboratory testing. 75.43 Section 75.43 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards... AND CERTIFICATION OF QUALITY OF AGRICULTURAL AND VEGETABLE SEEDS Fees and Charges § 75.43...

  18. 7 CFR 75.43 - Laboratory testing.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 3 2014-01-01 2014-01-01 false Laboratory testing. 75.43 Section 75.43 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards... AND CERTIFICATION OF QUALITY OF AGRICULTURAL AND VEGETABLE SEEDS Fees and Charges § 75.43...

  19. Mars Science Laboratory Workstation Test Set

    NASA Technical Reports Server (NTRS)

    Henriquez, David A.; Canham, Timothy K.; Chang, Johnny T.; Villaume, Nathaniel

    2009-01-01

    The Mars Science Laboratory developed the Workstation TestSet (WSTS) is a computer program that enables flight software development on virtual MSL avionics. The WSTS is the non-real-time flight avionics simulator that is designed to be completely software-based and run on a workstation class Linux PC.

  20. Battery testing at Argonne National Laboratory

    SciTech Connect

    DeLuca, W.H.; Gillie, K.R.; Kulaga, J.E.; Smaga, J.A.; Tummillo, A.F.; Webster, C.E.

    1993-03-25

    Argonne National Laboratory`s Analysis & Diagnostic Laboratory (ADL) tests advanced batteries under simulated electric and hybrid vehicle operating conditions. The ADL facilities also include a post-test analysis laboratory to determine, in a protected atmosphere if needed, component compositional changes and failure mechanisms. The ADL provides a common basis for battery performance characterization and life evaluations with unbiased application of tests and analyses. The battery evaluations and post-test examinations help identify factors that limit system performance and life, and the most-promising R&D approaches for overcoming these limitations. Since 1991, performance characterizations and/or life evaluations have been conducted on eight battery technologies (Na/S, Li/S, Zn/Br, Ni/MH, Ni/Zn, Ni/Cd, Ni/Fe, and lead-acid). These evaluations were performed for the Department of Energy`s. Office of Transportation Technologies, Electric and Hybrid Propulsion Division (DOE/OTT/EHP), and Electric Power Research Institute (EPRI) Transportation Program. The results obtained are discussed.

  1. Engineering and Design: Laboratory Investigations and Testing

    DTIC Science & Technology

    2007-11-02

    Requirements for Hazardous, Toxic, and Radioactive Waste (HTRW) and Ordnance and Explosive Waste (OEW) Activities . b. ER 1110-1-261, Quality Assurance of...Laboratory Testing Procedures. c. ER 1110-1-263, Chemical Data Quality Management for Hazardous Waste Remedial Activities . d. ER 1110-1-2002, Cement...Slag, and Pozzolan Acceptance Testing. e. ER 1110-2-8154, Water Quality Management at Corps Civil Works Projects. f. ER 200-2-3, Environmental

  2. Laboratory tests for single-event effects

    SciTech Connect

    Buchner, S.; McMorrow, D.; Melinger, J.; Campbell, A.B.

    1996-04-01

    Integrated circuits are currently tested at accelerators for their susceptibility to single-event effects (SEE`s). However, because of the cost and limited accessibility associated with accelerator testing, there is considerable interest in developing alternate testing methods. Two laboratory techniques for measuring SEE, one involving a pulsed laser and the other {sup 252}Cf, are described in detail in this paper. The pulsed laser provides information on the spatial and temporal dependence of SEE, information that has proven invaluable in understanding and mitigating SEE in spite of the differences in the physical mechanisms responsible for SEE induced by light and by ions. Considerable effort has been expended on developing {sup 252}Cf as a laboratory test for SEE, but the technique has not found wide use because it is severely limited by the low energy and short range of the emitted ions that are unable to reach junctions either covered with dielectric layers or deep below the surface. In fact, there are documented cases where single-event latchup (SEL) testing with {sub 252}Cf gave significantly different results from accelerator testing. A detailed comparison of laboratory and accelerator SEE data is presented in this review in order to establish the limits of each technique.

  3. CTBTO Contractor Laboratory Test Sample Production Report

    SciTech Connect

    Bob Hague; Tracy Houghton; Nick Mann; Matt Watrous

    2013-08-01

    In October 2012 scientists from both Idaho National Laboratory (INL) and the CTBTO contact laboratory at Seibersdorf, Austria designed a system and capability test to determine if the INL could produce and deliver a short lived radio xenon standard in time for the standard to be measured at the CTBTO contact laboratory at Seibersdorf, Austria. The test included sample standard transportation duration and potential country entrance delays at customs. On October 23, 2012 scientists at the Idaho National Laboratory (INL) prepared and shipped a Seibersdorf contract laboratory supplied cylinder. The canister contained 1.0 scc of gas that consisted of 70% xenon and 30% nitrogen by volume. The t0 was October 24, 2012, 1200 ZULU. The xenon content was 0.70 +/ 0.01 scc at 0 degrees C. The 133mXe content was 4200 +/ 155 dpm per scc of stable xenon on t0 (1 sigma uncertainty). The 133Xe content was 19000 +/ 800 dpm per scc of stable xenon on t0 (1 sigma uncertainty).

  4. [Usefulness of a single radial immunodiffusion method for the immediate diagnosis of abnormal fibrinogenemia in the laboratory].

    PubMed

    Yoshika, Masamichi; Komiyama, Yutaka; Terauchi, Satoe; Teraoka, Atsuko; Munakata, Machiko; Yasuda, Katsuhiko; Amakawa, Ryuuichi; Masaki, Hiroya; Takahashi, Hakuo

    2008-05-01

    Patients with dysfibrinogenemia demonstrate a low concentration of plasma fibrinogen. However, many cases remain a symptomatic and are incidentally identified on a pre-operative or screening test for pregnancy. Therefore, urgent diagnosis is desirable. To diagnose this abnormality, it is important to demonstrate a discrepancy between test results by the Clauss and immunologic methods. We use a single radial immunodiffusion (SRID) method to measure the fibrinogen level immunologically. We present one dysfibrinogenemia case diagnosed by SRID. The present case was 23 year-old pregnant female. She demonstrated a low plasma level of fibrinogen (91 mg/dl by the Clauss method) on a pre-delivery-screening test in the 39th week of pregnancy. We suspected dysfibrinogenemia, and measured the fibrinogen level immunologically with SRID. Briefly, we dissolved agar in 10% PBS solution and added 1 mg/ml anti-fibrinogen antibody. Then, patient plasma and 50-200 mg/dl of control plasma were placed on the agar overnight. The immunoreactive fibrinogen level in this patient was 400 mg/dl. Therefore, we diagnosed her as dysfibrinogenemia. She did not have a bleeding episode during the normal vaginal delivery even through fibrinogen was not transfused. The SRID method is readily available, and requires only an anti-fibrinogen antibody and agar, both of which are usually stocked by a general laboratory. The practical method and application described in this report provide instructive information for hospital laboratories.

  5. Advanced Materials Laboratory User Test Planning Guide

    NASA Technical Reports Server (NTRS)

    Orndoff, Evelyne

    2012-01-01

    Test process, milestones and inputs are unknowns to first-time users of the Advanced Materials Laboratory. The User Test Planning Guide aids in establishing expectations for both NASA and non-NASA facility customers. The potential audience for this guide includes both internal and commercial spaceflight hardware/software developers. It is intended to assist their test engineering personnel in test planning and execution. Material covered includes a roadmap of the test process, roles and responsibilities of facility and user, major milestones, facility capabilities, and inputs required by the facility. Samples of deliverables, test article interfaces, and inputs necessary to define test scope, cost, and schedule are included as an appendix to the guide.

  6. 1. VIEW EAST, COMPONENTS TEST LABORATORY SHOWING CATCH BASINS, TURBINE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. VIEW EAST, COMPONENTS TEST LABORATORY SHOWING CATCH BASINS, TURBINE TESTING AREA, AND PUMP TESTING TOWER. - Marshall Space Flight Center, East Test Area, Components Test Laboratory, Huntsville, Madison County, AL

  7. Parachute Testing for Mars Science Laboratory

    NASA Technical Reports Server (NTRS)

    2007-01-01

    The team developing the landing system for NASA's Mars Science Laboratory tested the deployment of an early parachute design in mid-October 2007 inside the world's largest wind tunnel, at NASA Ames Research Center, Moffett Field, California.

    In this image, an engineer is dwarfed by the parachute, which holds more air than a 280-square-meter (3,000-square-foot) house and is designed to survive loads in excess of 36,000 kilograms (80,000 pounds).

    The parachute, built by Pioneer Aerospace, South Windsor, Connecticut, has 80 suspension lines, measures more than 50 meters (165 feet) in length, and opens to a diameter of nearly 17 meters (55 feet). It is the largest disk-gap-band parachute ever built and is shown here inflated in the test section with only about 3.8 meters (12.5 feet) of clearance to both the floor and ceiling.

    The wind tunnel, which is 24 meters (80 feet) tall and 37 meters (120 feet) wide and big enough to house a Boeing 737, is part of the National Full-Scale Aerodynamics Complex, operated by the U.S. Air Force, Arnold Engineering Development Center.

    NASA's Jet Propulsion Laboratory, Pasadena, California, is building and testing the Mars Science Laboratory spacecraft for launch in 2009. The mission will land a roving analytical laboratory on the surface of Mars in 2010. JPL is a division of the California Institute of Technology.

  8. Battery testing at Argonne National Laboratory

    NASA Astrophysics Data System (ADS)

    Deluca, W. H.; Gillie, K. R.; Kulaga, J. E.; Smaga, J. A.; Tummillo, A. F.; Webster, C. E.

    Advanced battery technology evaluations are performed under simulated electric-vehicle operating conditions at the Analysis & Diagnostic Laboratory (ADL) of Argonne National Laboratory. The ADL results provide insight into those factors that limit battery performance and life. The ADL facilities include a test laboratory to conduct battery experimental evaluations under simulated application conditions and a post-test analysis laboratory to determine, in a protected atmosphere if needed, component compositional changes and failure mechanisms. This paper summarizes the performance characterizations and life evaluations conducted during FY-92 on both single cells and multi-cell modules that encompass six battery technologies (Na/S, Li/FeS, Ni/Metal-Hydride, Ni/Zn, Ni/Cd, Ni/Fe). These evaluations were performed for the Department of Energy, Office of Transportation Technologies, Electric and Hybrid Propulsion Division, and the Electric Power Research Institute. The ADL provides a common basis for battery performance characterization and life evaluations with unbiased application of tests and analyses. The results help identify the most promising R&D approaches for overcoming battery limitations, and provide battery users, developers, and program managers with a measure of the progress being made in battery R&D programs, a comparison of battery technologies, and basic data for modeling.

  9. Battery testing at Argonne National Laboratory

    SciTech Connect

    DeLuca, W.H.; Gillie, K.R.; Kulaga, J.E.; Smaga, J.A.; Tummillo, A.F.; Webster, C.E.

    1992-01-01

    Advanced battery technology evaluations are performed under simulated electric-vehicle operating conditions at the Analysis Diagnostic Laboratory (ADL) of Argonne National Laboratory. The ADL results provide insight into those factors that limit battery performance and life. The ADL facilities include a test laboratory to conduct battery experimental evaluations under simulated application conditions and a post-test analysis laboratory to determine, in a protected atmosphere if needed, component compositional changes and failure mechanisms. This paper summarizes the performance characterizations and life evaluations conducted during FY 1992 on both single cells and multi-cell modules that encompass six battery technologies [Na/S, Li/FeS, Ni/Metal-Hydride, Ni/Zn, Ni/Cd, Ni/Fe]. These evaluations were performed for the Department of Energy, Office of Transportation Technologies, Electric and Hybrid Propulsion Division, and the Electric Power Research Institute. The ADL provides a common basis for battery performance characterization and lie evaluations with unbiased application of tests and analyses. The results help identify the most promising R D approaches for overcoming battery limitations, and provide battery users, developers, and program managers with a measure of the progress being made in battery R D programs, a comparison of battery technologies, and basic data for modeling.

  10. Iowa Central Quality Fuel Testing Laboratory

    SciTech Connect

    Heach, Don; Bidieman, Julaine

    2013-09-30

    The objective of this project is to finalize the creation of an independent quality fuel testing laboratory on the campus of Iowa Central Community College in Fort Dodge, Iowa that shall provide the exploding biofuels industry a timely and cost-effective centrally located laboratory to complete all state and federal fuel and related tests that are required. The recipient shall work with various state regulatory agencies, biofuel companies and state and national industry associations to ensure that training and testing needs of their members and American consumers are met. The recipient shall work with the Iowa Department of Ag and Land Stewardship on the development of an Iowa Biofuel Quality Standard along with the Development of a standard that can be used throughout industry.

  11. 42 CFR 493.1421 - Condition: Laboratories performing moderate complexity testing; testing personnel.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... complexity testing; testing personnel. 493.1421 Section 493.1421 Public Health CENTERS FOR MEDICARE... LABORATORY REQUIREMENTS Personnel for Nonwaived Testing Laboratories Performing Moderate Complexity Testing § 493.1421 Condition: Laboratories performing moderate complexity testing; testing personnel....

  12. 42 CFR 493.1421 - Condition: Laboratories performing moderate complexity testing; testing personnel.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... complexity testing; testing personnel. 493.1421 Section 493.1421 Public Health CENTERS FOR MEDICARE... LABORATORY REQUIREMENTS Personnel for Nonwaived Testing Laboratories Performing Moderate Complexity Testing § 493.1421 Condition: Laboratories performing moderate complexity testing; testing personnel....

  13. Battery testing at Argonne National Laboratory

    NASA Astrophysics Data System (ADS)

    Deluca, W. H.; Gillie, K. R.; Kulaga, J. E.; Smaga, J. A.; Tummillo, A. F.; Webster, C. E.

    1993-03-01

    Argonne National Laboratory's Analysis & Diagnostic Laboratory (ADL) tests advanced batteries under simulated electric and hybrid vehicle operating conditions. The ADL facilities also include a post-test analysis laboratory to determine, in a protected atmosphere if needed, component compositional changes and failure mechanisms. The ADL provides a common basis for battery performance characterization and life evaluations with unbiased application of tests and analyses. The battery evaluations and post-test examinations help identify factors that limit system performance and life and the most-promising R&D approaches for overcoming these limitations. Since 1991, performance characterizations and/or life evaluations have been conducted on eight battery technologies: Na/S, Li/S, Zn/Br, Ni/MH, Ni/Zn, Ni/Cd, Ni/Fe, and lead-acid. These evaluations were performed for the Department of Energy's. Office of Transportation Technologies, Electric and Hybrid Propulsion Division (DOE/OTT/EHP), and Electric Power Research Institute (EPRI) Transportation Program. The results obtained are discussed.

  14. Battery testing at Argonne National Laboratory

    SciTech Connect

    DeLuca, W.H.; Gillie, K.R.; Kulaga, J.E.; Smaga, J.A.; Tummillo, A.F.; Webster, C.E.

    1993-03-25

    Argonne National Laboratory's Analysis Diagnostic Laboratory (ADL) tests advanced batteries under simulated electric and hybrid vehicle operating conditions. The ADL facilities also include a post-test analysis laboratory to determine, in a protected atmosphere if needed, component compositional changes and failure mechanisms. The ADL provides a common basis for battery performance characterization and life evaluations with unbiased application of tests and analyses. The battery evaluations and post-test examinations help identify factors that limit system performance and life, and the most-promising R D approaches for overcoming these limitations. Since 1991, performance characterizations and/or life evaluations have been conducted on eight battery technologies (Na/S, Li/S, Zn/Br, Ni/MH, Ni/Zn, Ni/Cd, Ni/Fe, and lead-acid). These evaluations were performed for the Department of Energy's. Office of Transportation Technologies, Electric and Hybrid Propulsion Division (DOE/OTT/EHP), and Electric Power Research Institute (EPRI) Transportation Program. The results obtained are discussed.

  15. Mars Science Laboratory Rover System Thermal Test

    NASA Technical Reports Server (NTRS)

    Novak, Keith S.; Kempenaar, Joshua E.; Liu, Yuanming; Bhandari, Pradeep; Dudik, Brenda A.

    2012-01-01

    On November 26, 2011, NASA launched a large (900 kg) rover as part of the Mars Science Laboratory (MSL) mission to Mars. The MSL rover is scheduled to land on Mars on August 5, 2012. Prior to launch, the Rover was successfully operated in simulated mission extreme environments during a 16-day long Rover System Thermal Test (STT). This paper describes the MSL Rover STT, test planning, test execution, test results, thermal model correlation and flight predictions. The rover was tested in the JPL 25-Foot Diameter Space Simulator Facility at the Jet Propulsion Laboratory (JPL). The Rover operated in simulated Cruise (vacuum) and Mars Surface environments (8 Torr nitrogen gas) with mission extreme hot and cold boundary conditions. A Xenon lamp solar simulator was used to impose simulated solar loads on the rover during a bounding hot case and during a simulated Mars diurnal test case. All thermal hardware was exercised and performed nominally. The Rover Heat Rejection System, a liquid-phase fluid loop used to transport heat in and out of the electronics boxes inside the rover chassis, performed better than predicted. Steady state and transient data were collected to allow correlation of analytical thermal models. These thermal models were subsequently used to predict rover thermal performance for the MSL Gale Crater landing site. Models predict that critical hardware temperatures will be maintained within allowable flight limits over the entire 669 Sol surface mission.

  16. Karyotype versus Microarray Testing for Genetic Abnormalities after Stillbirth

    PubMed Central

    Reddy, Uma M.; Page, Grier P.; Saade, George R.; Silver, Robert M.; Thorsten, Vanessa R.; Parker, Corette B.; Pinar, Halit; Willinger, Marian; Stoll, Barbara J.; Heim-Hall, Josefine; Varner, Michael W.; Goldenberg, Robert L.; Bukowski, Radek; Wapner, Ronald J.; Drews-Botsch, Carolyn D.; O’Brien, Barbara M.; Dudley, Donald J.; Levy, Brynn

    2015-01-01

    Background Genetic abnormalities have been associated with 6 to 13% of stillbirths, but the true prevalence may be higher. Unlike karyotype analysis, microarray analysis does not require live cells, and it detects small deletions and duplications called copy-number variants. Methods The Stillbirth Collaborative Research Network conducted a population-based study of stillbirth in five geographic catchment areas. Standardized postmortem examinations and karyotype analyses were performed. A single-nucleotide polymorphism array was used to detect copy-number variants of at least 500 kb in placental or fetal tissue. Variants that were not identified in any of three databases of apparently unaffected persons were then classified into three groups: probably benign, clinical significance unknown, or pathogenic. We compared the results of karyotype and microarray analyses of samples obtained after delivery. Results In our analysis of samples from 532 stillbirths, microarray analysis yielded results more often than did karyotype analysis (87.4% vs. 70.5%, P<0.001) and provided better detection of genetic abnormalities (aneuploidy or pathogenic copy-number variants, 8.3% vs. 5.8%; P = 0.007). Microarray analysis also identified more genetic abnormalities among 443 antepartum stillbirths (8.8% vs. 6.5%, P = 0.02) and 67 stillbirths with congenital anomalies (29.9% vs. 19.4%, P = 0.008). As compared with karyotype analysis, microarray analysis provided a relative increase in the diagnosis of genetic abnormalities of 41.9% in all stillbirths, 34.5% in antepartum stillbirths, and 53.8% in stillbirths with anomalies. Conclusions Microarray analysis is more likely than karyotype analysis to provide a genetic diagnosis, primarily because of its success with nonviable tissue, and is especially valuable in analyses of stillbirths with congenital anomalies or in cases in which karyotype results cannot be obtained. (Funded by the Eunice Kennedy Shriver National Institute of Child Health

  17. The Brookhaven National Laboratory Accelerator Test Facility

    SciTech Connect

    Batchelor, K.

    1992-01-01

    The Brookhaven National Laboratory Accelerator Test Facility comprises a 50 MeV traveling wave electron linear accelerator utilizing a high gradient, photo-excited, raidofrequency electron gun as an injector and an experimental area for study of new acceleration methods or advanced radiation sources using free electron lasers. Early operation of the linear accelerator system including calculated and measured beam parameters are presented together with the experimental program for accelerator physics and free electron laser studies.

  18. The Brookhaven National Laboratory Accelerator Test Facility

    SciTech Connect

    Batchelor, K.

    1992-09-01

    The Brookhaven National Laboratory Accelerator Test Facility comprises a 50 MeV traveling wave electron linear accelerator utilizing a high gradient, photo-excited, raidofrequency electron gun as an injector and an experimental area for study of new acceleration methods or advanced radiation sources using free electron lasers. Early operation of the linear accelerator system including calculated and measured beam parameters are presented together with the experimental program for accelerator physics and free electron laser studies.

  19. The laboratory test utilization management toolbox

    PubMed Central

    Baird, Geoffrey

    2014-01-01

    Efficiently managing laboratory test utilization requires both ensuring adequate utilization of needed tests in some patients and discouraging superfluous tests in other patients. After the difficult clinical decision is made to define the patients that do and do not need a test, a wealth of interventions are available to the clinician and laboratorian to help guide appropriate utilization. These interventions are collectively referred to here as the utilization management toolbox. Experience has shown that some tools in the toolbox are weak and other are strong, and that tools are most effective when many are used simultaneously. While the outcomes of utilization management studies are not always as concrete as may be desired, what data is available in the literature indicate that strong utilization management interventions are safe and effective measures to improve patient health and reduce waste in an era of increasing financial pressure. PMID:24969916

  20. Automation software for a materials testing laboratory

    NASA Technical Reports Server (NTRS)

    Mcgaw, Michael A.; Bonacuse, Peter J.

    1986-01-01

    A comprehensive software system for automating much of the experimental process has recently been completed at the Lewis Research Center's high-temperature fatigue and structures laboratory. The system was designed to support experiment definition and conduct, results analysis and archiving, and report generation activities. This was accomplished through the design and construction of several software systems, as well as through the use of several commercially available software products, all operating on a local, distributed minicomputer system. Experimental capabilities currently supported in an automated fashion include both isothermal and thermomechanical fatigue and deformation testing capabilities. The future growth and expansion of this system will be directed toward providing multiaxial test control, enhanced thermomechanical test control, and higher test frequency (hundreds of hertz).

  1. Laboratory tests of sludge-control additives

    SciTech Connect

    Tatnall, R.E.

    1996-07-01

    Laboratory {open_quotes}jar{close_quotes} tests compared eleven different fuel oil and diesel fuel sludge-control additives. Factors studied included (1) ability to disperse and prevent buildup of sludge deposits on surfaces, (2) ability to protect steel from corrosion, (3) ability to inhibit growth and proliferation of bacteria, and (4) ability to disperse water. Results varied greatly, and it was found that many commercial products do not do what they claim. It is concluded that fuel retailers should not believe manufacturers` claims for their additive products, but rather should test such products themselves to be sure that the benefits of treatment are real. A simplified form of the procedure used here is proposed as one way for dealers to do such testing.

  2. Predictors of resolution and persistence of renal laboratory abnormalities in Pediatric HIV infection

    PubMed Central

    Mitchell, Charles D.; Chernoff, Miriam C.; Seage, George R.; Purswani, Murli U.; Spiegel, Hans M.L.; Zilleruelo, Gaston; Abitbol, Carolyn; Heckman, Barbara; Ponce, Christopher B.; Oleske, James M.

    2014-01-01

    Background Among HIV infected youth, the role of renal disease (RD) and its management has become more important as children/adolescents age into young adulthood. Identification of predictors of abnormal renal laboratory events (RLE) may be helpful in the management of their HIV infection and its associated renal complications.” Methods Data collected from HIV-infected children and youth followed for ≥48 months was analyzed to identify predictors of resolution versus persistence of RLE and determine the utility of RLE to predict the onset of RD. Analysis included descriptive and inferential methods using a multivariable extended Cox proportional hazards model. Results 428 of 1874 at risk children (23%) developed RLE, which persisted in 229 of 428(54%). CD4<25% (hazard ratio[HR] 0.63, p<0.002) and HIV viral load>100,000 copies/ml (HR 0.31, p<0.01) were associated with reduced rates of resolution. Exposure to HAART/nephrotoxic HAART prior to or subsequent to RLE in most cases were not. Persistence of RLE was 88% sensitive for identifying new RD. Negative predictive values for RD were >95% for both the at risk cohort and in those with RLE. Conclusions Advanced HIV disease predicted persistence of RLE in HIV-infected youth. Persistent RLE were useful for identifying RD. PMID:25149850

  3. Laboratory procedures for waste form testing

    SciTech Connect

    Mast, E.S.

    1994-09-19

    The 100 and 300 areas of the Hanford Site are included on the US Environmental Protection Agencies (EPA) National Priorities List under the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA). Soil washing is a treatment process that is being considered for the remediation of the soil in these areas. Contaminated soil washing fines can be mixed or blended with cementations materials to produce stable waste forms that can be used for beneficial purposes in mixed or low-level waste landfills, burial trenches, environmental restoration sites, and other applications. This process has been termed co-disposal. The Co-Disposal Treatability Study Test Plan is designed to identify a range of cement-based formulations that could be used in disposal efforts in Hanford in co-disposal applications. The purpose of this document is to provide explicit procedural information for the testing of co-disposal formulations. This plan also provides a discussion of laboratory safety and quality assurance necessary to ensure safe, reproducible testing in the laboratory.

  4. Laboratory rock mechanics testing manual. Public draft

    SciTech Connect

    Shuri, F S; Cooper, J D; Hamill, M L

    1981-10-01

    Standardized laboratory rock mechanics testing procedures have been prepared for use in the National Terminal Waste Storage Program. The procedures emphasize equipment performance specifications, documentation and reporting, and Quality Assurance acceptance criteria. Sufficient theoretical background is included to allow the user to perform the necessary data reduction. These procedures incorporate existing standards when possible, otherwise they represent the current state-of-the-art. Maximum flexibility in equipment design has been incorporated to allow use of this manual by existing groups and to encourage future improvements.

  5. Test plan for ISV laboratory-pyrolysis testing

    SciTech Connect

    McAtee, R.E.

    1991-09-01

    The objective of the laboratory-pyrolysis studies is to obtain information on the high temperature (< 1200{degree}C) degradation and alteration of organic chemicals and materials similar to those found in the Radioactive Waste Management Complex, Pit 9. This test plan describes experimental procedures, sampling and analysis strategy, sampling procedures, sample control, and document management. It addresses safety issues in the experimental apparatus and procedures, personal training, and hazardous waste disposal. Finally, it describes the data quality objectives using the EPA tiered approach to treatability studies to define where research/scoping tests fit into these studies and the EPA analytical levels required for the tests.

  6. Abnormal ventilation scans in middle-aged smokers. Comparison with tests of overall lung function

    SciTech Connect

    Barter, S.J.; Cunningham, D.A.; Lavender, J.P.; Gibellino, F.; Connellan, S.J.; Pride, N.B.

    1985-07-01

    The uniformity of regional ventilation during tidal breathing has been assessed using continuous inhalation of krypton-81m in 43 male, lifelong nonsmokers and 46 male, current cigarette smokers (mean daily consumption 24.1 cigarettes/day) between 44 and 61 yr of age and with mild or no respiratory symptoms. All subjects had normal chest radiographs. The results of the ventilation scans were compared with tests of overall lung function (spirometry, maximal expiratory flow-volume curves, and single-breath N2 test). Diffuse abnormalities of the ventilation scan were found in 19 (41%) of the 46 smokers but in none of the nonsmokers. Focal abnormalities were found in 7 smokers and 3 nonsmokers. Smokers showed the expected abnormalities in overall lung function (reduced FEV1 and VC, increased single-breath N2 slope, and closing volume), but in individual smokers there was only a weak relation between the severity of abnormality of overall lung function and an abnormal ventilation scan. Abnormal scans could be found when overall lung function was normal and were not invariably found when significant abnormalities in FEV1/VC or N2 slope were present. There was no relation between the presence of chronic expectoration and an abnormal scan. The prognostic significance of an abnormal ventilation scan in such smokers remains to be established.

  7. Remotely accessible laboratory for MEMS testing

    NASA Astrophysics Data System (ADS)

    Sivakumar, Ganapathy; Mulsow, Matthew; Melinger, Aaron; Lacouture, Shelby; Dallas, Tim E.

    2010-02-01

    We report on the construction of a remotely accessible and interactive laboratory for testing microdevices (aka: MicroElectroMechancial Systems - MEMS). Enabling expanded utilization of microdevices for research, commercial, and educational purposes is very important for driving the creation of future MEMS devices and applications. Unfortunately, the relatively high costs associated with MEMS devices and testing infrastructure makes widespread access to the world of MEMS difficult. The creation of a virtual lab to control and actuate MEMS devices over the internet helps spread knowledge to a larger audience. A host laboratory has been established that contains a digital microscope, microdevices, controllers, and computers that can be logged into through the internet. The overall layout of the tele-operated MEMS laboratory system can be divided into two major parts: the server side and the client side. The server-side is present at Texas Tech University, and hosts a server machine that runs the Linux operating system and is used for interfacing the MEMS lab with the outside world via internet. The controls from the clients are transferred to the lab side through the server interface. The server interacts with the electronics required to drive the MEMS devices using a range of National Instruments hardware and LabView Virtual Instruments. An optical microscope (100 ×) with a CCD video camera is used to capture images of the operating MEMS. The server broadcasts the live video stream over the internet to the clients through the website. When the button is pressed on the website, the MEMS device responds and the video stream shows the movement in close to real time.

  8. Thermal-Structures and Materials Testing Laboratory

    NASA Technical Reports Server (NTRS)

    Teate, Anthony A.

    1997-01-01

    Since its inception and successful implementation in 1997 at James Madison University, the Thermal Structures and Materials Testing Laboratory (T-SaMTL) funded by the NASA Langley Research Center is evolving into one of the University's premier and exemplary efforts to increase minority representation in the sciences and mathematics. Serving ten (10) students and faculty directly and almost fifty (50) students indirectly, T-SAMTL, through its recruitment efforts, workshops, mentoring program, tutorial services and its research and computational laboratories has marked the completion of the first year with support from NASA totaling $ 100,000. Beginning as an innovative academic research and mentoring program for underrepresented minority science and mathematics students, the program now boasts a constituency which consists of 50% graduating seniors in the spring of 1998 with 50% planning to go to graduate school. The program's intent is to increase the number of underrepresented minorities who receive doctoral degrees in the sciences by initiating an academically enriched research program aimed at strengthening the academic and self actualization skills of undergraduate students with the potential to pursue doctoral study in the sciences. The program provides financial assistance, academic enrichment, and professional and personal development support for minority students who demonstrate the potential and strong desire to pursue careers in the sciences and mathematics. James Madison University was awarded the first $100,000, in April 1997, by The NASA Langley Research Center for establishment and support of its Thermal Structures and Materials Testing

  9. Mars Science Laboratory Flight Software Internal Testing

    NASA Technical Reports Server (NTRS)

    Jones, Justin D.; Lam, Danny

    2011-01-01

    The Mars Science Laboratory (MSL) team is sending the rover, Curiosity, to Mars, and therefore is physically and technically complex. During my stay, I have assisted the MSL Flight Software (FSW) team in implementing functional test scripts to ensure that the FSW performs to the best of its abilities. There are a large number of FSW requirements that have been written up for implementation; however I have only been assigned a few sections of these requirements. There are many stages within testing; one of the early stages is FSW Internal Testing (FIT). The FIT team can accomplish this with simulation software and the MSL Test Automation Kit (MTAK). MTAK has the ability to integrate with the Software Simulation Equipment (SSE) and the Mission Processing and Control System (MPCS) software which makes it a powerful tool within the MSL FSW development process. The MSL team must ensure that the rover accomplishes all stages of the mission successfully. Due to the natural complexity of this project there is a strong emphasis on testing, as failure is not an option. The entire mission could be jeopardized if something is overlooked.

  10. Electronics systems test laboratory testing of shuttle communications systems

    NASA Technical Reports Server (NTRS)

    Stoker, C. J.; Bromley, L. K.

    1985-01-01

    Shuttle communications and tracking systems space to space and space to ground compatibility and performance evaluations are conducted in the NASA Johnson Space Center Electronics Systems Test Laboratory (ESTL). This evaluation is accomplished through systems verification/certification tests using orbiter communications hardware in conjunction with other shuttle communications and tracking external elements to evaluate end to end system compatibility and to verify/certify that overall system performance meets program requirements before manned flight usage. In this role, the ESTL serves as a multielement major ground test facility. The ESTL capability and program concept are discussed. The system test philosophy for the complex communications channels is described in terms of the major phases. Results of space to space and space to ground systems tests are presented. Several examples of the ESTL's unique capabilities to locate and help resolve potential problems are discussed in detail.

  11. Laboratory Test Surveillance following Acute Kidney Injury

    PubMed Central

    Matheny, Michael E.; Peterson, Josh F.; Eden, Svetlana K.; Hung, Adriana M.; Speroff, Theodore; Abdel-Kader, Khaled; Parr, Sharidan K.; Ikizler, T. Alp; Siew, Edward D.

    2014-01-01

    Background Patients with hospitalized acute kidney injury (AKI) are at increased risk for accelerated loss of kidney function, morbidity, and mortality. We sought to inform efforts at improving post-AKI outcomes by describing the receipt of renal-specific laboratory test surveillance among a large high-risk cohort. Methods We acquired clinical data from the Electronic health record (EHR) of 5 Veterans Affairs (VA) hospitals to identify patients hospitalized with AKI from January 1st, 2002 to December 31st, 2009, and followed these patients for 1 year or until death, enrollment in palliative care, or improvement in renal function to estimated GFR (eGFR) ≥60 L/min/1.73 m2. Using demographic data, administrative codes, and laboratory test data, we evaluated the receipt and timing of outpatient testing for serum concentrations of creatinine and any as well as quantitative proteinuria recommended for CKD risk stratification. Additionally, we reported the rate of phosphorus and parathyroid hormone (PTH) monitoring recommended for chronic kidney disease (CKD) patients. Results A total of 10,955 patients admitted with AKI were discharged with an eGFR<60 mL/min/1.73 m2. During outpatient follow-up at 90 and 365 days, respectively, creatinine was measured on 69% and 85% of patients, quantitative proteinuria was measured on 6% and 12% of patients, PTH or phosphorus was measured on 10% and 15% of patients. Conclusions Measurement of creatinine was common among all patients following AKI. However, patients with AKI were infrequently monitored with assessments of quantitative proteinuria or mineral metabolism disorder, even for patients with baseline kidney disease. PMID:25117447

  12. 42 CFR 493.1403 - Condition: Laboratories performing moderate complexity testing; laboratory director.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 5 2013-10-01 2013-10-01 false Condition: Laboratories performing moderate complexity testing; laboratory director. 493.1403 Section 493.1403 Public Health CENTERS FOR MEDICARE... LABORATORY REQUIREMENTS Personnel for Nonwaived Testing Laboratories Performing Moderate Complexity...

  13. 42 CFR 493.1403 - Condition: Laboratories performing moderate complexity testing; laboratory director.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 5 2012-10-01 2012-10-01 false Condition: Laboratories performing moderate complexity testing; laboratory director. 493.1403 Section 493.1403 Public Health CENTERS FOR MEDICARE... LABORATORY REQUIREMENTS Personnel for Nonwaived Testing Laboratories Performing Moderate Complexity...

  14. 42 CFR 493.1403 - Condition: Laboratories performing moderate complexity testing; laboratory director.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 5 2011-10-01 2011-10-01 false Condition: Laboratories performing moderate complexity testing; laboratory director. 493.1403 Section 493.1403 Public Health CENTERS FOR MEDICARE... LABORATORY REQUIREMENTS Personnel for Nonwaived Testing Laboratories Performing Moderate Complexity...

  15. 42 CFR 493.1403 - Condition: Laboratories performing moderate complexity testing; laboratory director.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 5 2014-10-01 2014-10-01 false Condition: Laboratories performing moderate complexity testing; laboratory director. 493.1403 Section 493.1403 Public Health CENTERS FOR MEDICARE... LABORATORY REQUIREMENTS Personnel for Nonwaived Testing Laboratories Performing Moderate Complexity...

  16. 42 CFR 493.1403 - Condition: Laboratories performing moderate complexity testing; laboratory director.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 5 2010-10-01 2010-10-01 false Condition: Laboratories performing moderate complexity testing; laboratory director. 493.1403 Section 493.1403 Public Health CENTERS FOR MEDICARE... LABORATORY REQUIREMENTS Personnel for Nonwaived Testing Laboratories Performing Moderate Complexity...

  17. Long-Term Evaluation of Abnormal Behavior in Adult Ex-laboratory Chimpanzees (Pan troglodytes) Following Re-socialization

    PubMed Central

    Kalcher-Sommersguter, Elfriede; Franz-Schaider, Cornelia; Preuschoft, Signe; Crailsheim, Karl

    2013-01-01

    Adverse rearing conditions are considered a major factor in the development of abnormal behavior. We investigated the overall levels, the prevalence and the diversity of abnormal behavior of 18 adult former laboratory chimpanzees, who spent about 20 years single caged, over a two-year period following re-socialization. According to the onset of deprivation, the individuals were classified as early deprived (EDs, mean: 1.2 years) or late deprived (LDs, mean: 3.6 years). The results are based on 187.5 hours of scan sampling distributed over three sample periods: subsequent to re-socialization and during the first and second year of group-living. While the overall levels and the diversity of abnormal behavior remained stable over time in this study population, the amplifying effects of age at onset of deprivation became apparent as the overall levels of abnormal behavior of EDs were far above those of LDs in the first and second year of group-living, but not immediately after re-socialization. The most prevalent abnormal behaviors, including eating disorders and self-directed behaviors, however, varied in their occurrence within subjects across the periods. Most important, the significance of social companionship became obvious as the most severe forms of abnormal behavior, such as dissociative and self-injurious behaviors declined. PMID:25379228

  18. The patient portal and abnormal test results: An exploratory study of patient experiences

    PubMed Central

    Giardina, Traber Davis; Modi, Varsha; Parrish, Danielle E.; Singh, Hardeep

    2016-01-01

    Many health care institutions are implementing patient portals that allow patients to track and maintain their personal health information, mostly in response to the Health Information Technology for Economic and Clinical Health Act requirements. Test results review is an area of high interest to patients and provides an opportunity to foster their involvement in preventing abnormal test results from being overlooked, a common patient safety concern. However, little is known about how patients engage with portals to review abnormal results and which strategies could facilitate that interaction in order to ensure safe follow-up on abnormalities. The objective of this qualitative study was to explore patients’ experiences related to abnormal test result notifications through patient portals. The authors conducted semi-structured telephone interviews with 13 participants, patients and primary caregivers, between February 2014 and October 2014. Using content analysis, the authors explored patient experiences accessing abnormal test results through their portals. Respondents strongly favored access to all types of abnormal test results, but they raised several concerns including need for more timely notification and not being able to interpret the exact relevance of the result. Respondents’ personal experiences with physicians, test result notification, and the portal heavily influenced respondents’ notification preferences. Patient experiences with portals could be improved by development of strategies to help patients understand and manage the information received. These findings suggest important considerations for health professionals and institutions aiming to better engage patients in follow-up of their test results.

  19. Response to an abnormal ovarian cancer-screening test result: test of the social cognitive processing and cognitive social health information processing models.

    PubMed

    Andrykowski, Michael A; Pavlik, Edward J

    2011-04-01

    All cancer screening tests produce a proportion of abnormal results requiring follow up. Consequently, the cancer-screening setting is a natural laboratory for examining psychological and behavioural response to a threatening health-related event. This study tested hypotheses derived from the social cognitive processing and cognitive-social health information processing models in trying to understand response to an abnormal ovarian cancer (OC) screening test result. Women (n = 278) receiving an abnormal screening test result a mean of 7 weeks earlier were assessed prior to a repeat screening test intended to clarify their previous abnormal result. Measures of disposition (optimism, informational coping style), social environment (social support and constraint), emotional processing, distress, and benefit finding were obtained. Regression analyses indicated greater distress was associated with greater social constraint and emotional processing and a monitoring coping style in women with a family history of OC. Distress was unrelated to social support. Greater benefit finding was associated with both greater social constraint and support and greater distress. The primacy of social constraint in accounting for both benefit finding and distress was noteworthy and warrants further research on the role of social constraint in adaptation to stressful events.

  20. Mars Science Laboratory Boot Robustness Testing

    NASA Technical Reports Server (NTRS)

    Banazadeh, Payam; Lam, Danny

    2011-01-01

    Mars Science Laboratory (MSL) is one of the most complex spacecrafts in the history of mankind. Due to the nature of its complexity, a large number of flight software (FSW) requirements have been written for implementation. In practice, these requirements necessitate very complex and very precise flight software with no room for error. One of flight software's responsibilities is to be able to boot up and check the state of all devices on the spacecraft after the wake up process. This boot up and initialization is crucial to the mission success since any misbehavior of different devices needs to be handled through the flight software. I have created a test toolkit that allows the FSW team to exhaustively test the flight software under variety of different unexpected scenarios and validate that flight software can handle any situation after booting up. The test includes initializing different devices on spacecraft to different configurations and validate at the end of the flight software boot up that the flight software has initialized those devices to what they are suppose to be in that particular scenario.

  1. Abnormal ovarian cancer screening test result: women's informational, psychological and practical needs.

    PubMed

    Ryan, Patricia Y; Graves, Kristi D; Pavlik, Edward J; Andrykowski, Michael A

    2007-01-01

    Considerable effort has been devoted to the identification of cost-effective approaches to screening for ovarian cancer (OC). Transvaginal ultrasound (TVS) is one such screening approach. Approximately 5-7% of routine TVS screening tests yield abnormal results. Some women experience significant distress after receipt of an abnormal TVS screening test. Four focus groups provided in-depth, qualitative data regarding the informational, psychological, and practical needs of women after the receipt of an abnormal TVS result. Through question and content analytic procedures, we identified four themes: anticipation, emotional response, role of the screening technician, and impact of prior cancer experiences. Results provide initial guidance toward development of interventions to promote adaptive responses after receipt of an abnormal cancer screening test result.

  2. TRITIUM LABORATORY, TRA666, INTERIOR. HYDRAULIC TEST FACILITY. INSIDE LABORATORY 103. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    TRITIUM LABORATORY, TRA-666, INTERIOR. HYDRAULIC TEST FACILITY. INSIDE LABORATORY 103. CAMERA FACES NORTH. INL NEGATIVE NO. HD46-24-1. Mike Crane, Photographer, 2/2005 - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

  3. 19. Interior view of HVAC room in Components Test Laboratory ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    19. Interior view of HVAC room in Components Test Laboratory (T-27), looking toward east wall. Photograph shows upgraded instrumentation, machinery, and technological modifications for HVAC system installed in 1997-99 to accommodate component testing requirements for the Atlas V missile. - Air Force Plant PJKS, Systems Integration Laboratory, Components Test Laboratory, Waterton Canyon Road & Colorado Highway 121, Lakewood, Jefferson County, CO

  4. 19 CFR 151.54 - Testing by Customs laboratory.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 2 2013-04-01 2013-04-01 false Testing by Customs laboratory. 151.54 Section 151... Other Metal-Bearing Materials § 151.54 Testing by Customs laboratory. Samples taken in accordance with § 151.52 shall be promptly forwarded to the appropriate Customs laboratory for testing in...

  5. 19 CFR 151.54 - Testing by Customs laboratory.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 2 2011-04-01 2011-04-01 false Testing by Customs laboratory. 151.54 Section 151... Other Metal-Bearing Materials § 151.54 Testing by Customs laboratory. Samples taken in accordance with § 151.52 shall be promptly forwarded to the appropriate Customs laboratory for testing in...

  6. 19 CFR 151.54 - Testing by Customs laboratory.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 19 Customs Duties 2 2014-04-01 2014-04-01 false Testing by Customs laboratory. 151.54 Section 151... Other Metal-Bearing Materials § 151.54 Testing by Customs laboratory. Samples taken in accordance with § 151.52 shall be promptly forwarded to the appropriate Customs laboratory for testing in...

  7. 19 CFR 151.54 - Testing by Customs laboratory.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 19 Customs Duties 2 2012-04-01 2012-04-01 false Testing by Customs laboratory. 151.54 Section 151... Other Metal-Bearing Materials § 151.54 Testing by Customs laboratory. Samples taken in accordance with § 151.52 shall be promptly forwarded to the appropriate Customs laboratory for testing in...

  8. 18. Interior view of HVAC room in Components Test Laboratory ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    18. Interior view of HVAC room in Components Test Laboratory (T-27), showing northwest corner. Photograph shows upgraded instrumentation, piping, and technological modifications for HVAC system installed in 1997-99 to accommodate component testing requirements for the Atlas V missile. - Air Force Plant PJKS, Systems Integration Laboratory, Components Test Laboratory, Waterton Canyon Road & Colorado Highway 121, Lakewood, Jefferson County, CO

  9. 11. Interior view of control room in Components Test Laboratory ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. Interior view of control room in Components Test Laboratory (T-27), looking north. Photograph shows upgraded instrumentation, piping, and technological modifications installed in 1997-99 to accommodate component testing requirements for the Atlas V missile. - Air Force Plant PJKS, Systems Integration Laboratory, Components Test Laboratory, Waterton Canyon Road & Colorado Highway 121, Lakewood, Jefferson County, CO

  10. HCG stimulation test in children with abnormal sexual development.

    PubMed Central

    Grant, D B; Laurance, B M; Atherden, S M; Ryness, J

    1976-01-01

    Plasma testosterone was estimated by radioimmunoassay in 60 children with disorders of sexual development before and after stimulation with human chorionic gonadotrophin (HCG). In 21 children the testosterone levels after 3 and 5 daily injections of 1000 units HCG were compared and good correlation was found between the paired results (r =0-93), suggesting that the 5-day HCG test has no advantage over the 3-day test. In 7 boys with apparently normal genital development the increments in plasma testosterone ranged from 2-0 to 8-5 nmol/1 after 3 injections of HCG. 10 boys with anorchia showed little response to HCG stimulation, but in patients with other disorders, such as micropenis (10), cryptorchidism (8), hermaphroditism (3), male pseudohermaphroditism (13), hypospadias (3), and sex chromosome anomalies (6), there was considerable variation in the plasma testosterone level after HCG. In 2 boys with suspected anorchia the results suggested that testes were present and this was confirmed at operation. PMID:9030

  11. The value of Bayes' theorem for interpreting abnormal test scores in cognitively healthy and clinical samples.

    PubMed

    Gavett, Brandon E

    2015-03-01

    The base rates of abnormal test scores in cognitively normal samples have been a focus of recent research. The goal of the current study is to illustrate how Bayes' theorem uses these base rates--along with the same base rates in cognitively impaired samples and prevalence rates of cognitive impairment--to yield probability values that are more useful for making judgments about the absence or presence of cognitive impairment. Correlation matrices, means, and standard deviations were obtained from the Wechsler Memory Scale--4th Edition (WMS-IV) Technical and Interpretive Manual and used in Monte Carlo simulations to estimate the base rates of abnormal test scores in the standardization and special groups (mixed clinical) samples. Bayes' theorem was applied to these estimates to identify probabilities of normal cognition based on the number of abnormal test scores observed. Abnormal scores were common in the standardization sample (65.4% scoring below a scaled score of 7 on at least one subtest) and more common in the mixed clinical sample (85.6% scoring below a scaled score of 7 on at least one subtest). Probabilities varied according to the number of abnormal test scores, base rates of normal cognition, and cutoff scores. The results suggest that interpretation of base rates obtained from cognitively healthy samples must also account for data from cognitively impaired samples. Bayes' theorem can help neuropsychologists answer questions about the probability that an individual examinee is cognitively healthy based on the number of abnormal test scores observed.

  12. Optimizing Tuberculosis Testing for Basic Laboratories

    PubMed Central

    Ramos, Eric; Schumacher, Samuel G.; Siedner, Mark; Herrera, Beatriz; Quino, Willi; Alvarado, Jessica; Montoya, Rosario; Grandjean, Louis; Martin, Laura; Sherman, Jonathan M.; Gilman, Robert H.; Evans, Carlton A.

    2010-01-01

    Optimal tuberculosis testing usually involves sputum centrifugation followed by broth culture. However, centrifuges are biohazardous and scarce in the resource-limited settings where most tuberculosis occurs. To optimize tuberculosis testing for these settings, centrifugation of 111 decontaminated sputum samples was compared with syringe-aspiration through polycarbonate membrane-filters that were then cultured in broth. To reduce the workload of repeated microscopic screening of broth cultures for tuberculosis growth, the colorimetric redox indicator 2,3-diphenyl-5-(2-thienyl) tetrazolium chloride was added to the broth, which enabled naked-eye detection of culture positivity. This combination of filtration and colorimetric growth-detection gave similar results to sputum centrifugation followed by culture microscopy regarding mean colony counts (43 versus 48; P = 0.6), contamination rates (0.9% versus 1.8%; P = 0.3), and sensitivity (94% versus 95%; P = 0.7), suggesting equivalency of the two methods. By obviating centrifugation and repeated microscopic screening of cultures, this approach may constitute a more appropriate technology for rapid and sensitive tuberculosis diagnosis in basic laboratories. PMID:20889887

  13. Pre-operative laboratory testing: A prospective study on comparison and cost analysis

    PubMed Central

    Keshavan, Venkatesh H; Swamy, Chidananda MN

    2016-01-01

    Background and Aims: Pre-operative investigations are performed before any surgical intervention under anaesthesia. Many are considered as routine. However, there are no clear guidelines regarding these in India. We aim to look at the relevance of the laboratory investigations ordered routinely and their cost implications compared with the National Institute of Clinical Excellence (NICE) guidelines. Methods: This prospective study was carried out at a tertiary care hospital. A total of 163 patients scheduled for elective surgical procedures were included in this study. Neither the surgeons nor anaesthesiologists involved in the case were aware of the study. The laboratory investigations of the patients who underwent surgery were noted. All values were categorised as normal or abnormal and they were assessed as indicated or unindicated based on NICE guidelines. Results: One hundred and sixty-three patients were subjected to a total of 984 tests. Forty three patients (26%) were subjected to tests as per NICE guidelines. Of the 984 tests, 515 tests were unindicated (52%). Out of the 515 unindicated tests, 7 (1.3%) were abnormal. None of these seven tests required any intervention or change of anaesthetic plan. The most common unindicated tests done were cardiac echocardiography and chest X-ray (92.5% and 93% respectively). The additional cost incurred towards unindicated tests was 63% of the total cost for the tests. Conclusion: Pre-operative laboratory investigations add to cost significantly. Patient premorbid conditions and surgical grade should guide the clinician to request for the relevant laboratory tests. PMID:27942058

  14. The mass storage testing laboratory at GSFC

    NASA Technical Reports Server (NTRS)

    Venkataraman, Ravi; Williams, Joel; Michaud, David; Gu, Heng; Kalluri, Atri; Hariharan, P. C.; Kobler, Ben; Behnke, Jeanne; Peavey, Bernard

    1998-01-01

    Industry-wide benchmarks exist for measuring the performance of processors (SPECmarks), and of database systems (Transaction Processing Council). Despite storage having become the dominant item in computing and IT (Information Technology) budgets, no such common benchmark is available in the mass storage field. Vendors and consultants provide services and tools for capacity planning and sizing, but these do not account for the complete set of metrics needed in today's archives. The availability of automated tape libraries, high-capacity RAID systems, and high- bandwidth interconnectivity between processor and peripherals has led to demands for services which traditional file systems cannot provide. File Storage and Management Systems (FSMS), which began to be marketed in the late 80's, have helped to some extent with large tape libraries, but their use has introduced additional parameters affecting performance. The aim of the Mass Storage Test Laboratory (MSTL) at Goddard Space Flight Center is to develop a test suite that includes not only a comprehensive check list to document a mass storage environment but also benchmark code. Benchmark code is being tested which will provide measurements for both baseline systems, i.e. applications interacting with peripherals through the operating system services, and for combinations involving an FSMS. The benchmarks are written in C, and are easily portable. They are initially being aimed at the UNIX Open Systems world. Measurements are being made using a Sun Ultra 170 Sparc with 256MB memory running Solaris 2.5.1 with the following configuration: 4mm tape stacker on SCSI 2 Fast/Wide; 4GB disk device on SCSI 2 Fast/Wide; and Sony Petaserve on Fast/Wide differential SCSI 2.

  15. Quality of HIV laboratory testing in Tanzania: a situation analysis.

    PubMed

    Mfinanga, G S; Mutayoba, B; Mbogo, G; Kahwa, A; Kimaro, G; Mhame, P P; Mwangi, C; Malecela, M N; Kitua, A Y

    2007-01-01

    Tanzania is scaling up prevention, treatment, care and support of individuals affected with HIV. There is therefore a need for high quality and reliable HIV infection testing and AIDS staging. The objective of this study was to assess laboratories capacities of services in terms of HIV testing and quality control. A baseline survey was conducted from December 2004 to February 2005 in 12 laboratories which were conveniently selected to represent all the zones of Tanzania. The questionnaires comprised of questions on laboratory particulars, internal and external quality control for HIV testing and quality control of reagents. Source and level of customer satisfaction of HIV test kits supply was established. Of 12 laboratories, nine used rapid tests for screening and two used rapid tests for diagnosis. In the 12 laboratories, four used double ELISA and five used single ELISA and three did not use ELISA. Confirmatory tests observed were Western Blot in three laboratories, DNA PCR in two laboratories, CD4 counting in seven laboratories, and viral load in two laboratories. Although all laboratories conducted quality control (QC) of the HIV kits, only two laboratories had Standard Operating Procedures (SOPs). Internal and external quality control (EQC) was done at varied proportions with the highest frequency of 55.6% (5/9) for internal quality control (IQC) for rapid tests and EQC for ELISA, and the lowest frequency of 14.3% (1/ 7) for IQC for CD4 counting. None of the nine laboratories which conducted QC for reagents used for rapid tests and none of the five which performed IQC and EQC had SOPs. HIV kits were mainly procured by the Medical Store Department and most of laboratories were not satisfied with the delay in procurement procedures. Most of the laboratories used rapid tests only, while some used both rapid tests and ELISA method for HIV testing. In conclusion, the survey revealed inadequacy in Good Laboratory Practice and poor laboratory quality control process

  16. 49 CFR 199.107 - Drug testing laboratory.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Drug testing laboratory. 199.107 Section 199.107... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY DRUG AND ALCOHOL TESTING Drug Testing § 199.107 Drug testing laboratory. (a) Each operator shall use for the drug testing required by...

  17. 49 CFR 199.107 - Drug testing laboratory.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 3 2014-10-01 2014-10-01 false Drug testing laboratory. 199.107 Section 199.107... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY DRUG AND ALCOHOL TESTING Drug Testing § 199.107 Drug testing laboratory. (a) Each operator shall use for the drug testing required by...

  18. 49 CFR 199.107 - Drug testing laboratory.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Drug testing laboratory. 199.107 Section 199.107... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY DRUG AND ALCOHOL TESTING Drug Testing § 199.107 Drug testing laboratory. (a) Each operator shall use for the drug testing required by...

  19. 49 CFR 199.107 - Drug testing laboratory.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 3 2012-10-01 2012-10-01 false Drug testing laboratory. 199.107 Section 199.107... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY DRUG AND ALCOHOL TESTING Drug Testing § 199.107 Drug testing laboratory. (a) Each operator shall use for the drug testing required by...

  20. Preoperative Laboratory Testing in Patients Undergoing Elective, Low-Risk Ambulatory Surgery

    PubMed Central

    Benarroch-Gampel, Jaime; Sheffield, Kristin M.; Duncan, Casey B.; Brown, Kimberly M.; Han, Yimei; Townsend, Courtney M.; Riall, Taylor S.

    2012-01-01

    Background Routine preoperative laboratory testing for ambulatory surgery is not recommended. Methods Patients who underwent elective hernia repair (N = 73,596) were identified from the National Surgical Quality Improvement Program (NSQIP) database (2005–2010). Patterns of preoperative testing were examined. Multivariate analyses were used to identify factors associated with testing and postoperative complications. Results A total of 46,977 (63.8%) patients underwent testing, with at least one abnormal test recorded in 61.6% of patients. In patients with no NSQIP comorbidities (N = 25,149) and no clear indication for testing, 54% received at least one test. In addition, 15.3% of tested patients underwent laboratory testing the day of the operation. In this group, surgery was done despite abnormal results in 61.6% of same day tests. In multivariate analyses, testing was associated with older age, ASA (American Society of Anesthesiologists) class >1, hypertension, ascites, bleeding disorders, systemic steroids, and laparoscopic procedures. Major complications (reintubation, pulmonary embolus, stroke, renal failure, coma, cardiac arrest, myocardial infarction, septic shock, bleeding, or death) occurred in 0.3% of patients. After adjusting for patient and procedure characteristics, neither testing nor abnormal results were associated with postoperative complications. Conclusions Preoperative testing is overused in patients undergoing low-risk, ambulatory surgery. Neither testing nor abnormal results were associated with postoperative outcomes. On the basis of high rates of testing in healthy patients, physician and/or facility preference and not only patient condition currently dictate use. Involvement from surgical societies is necessary to establish guidelines for preoperative testing. PMID:22868362

  1. Abnormalities of thyroid function tests in hospital inpatients.

    PubMed Central

    Sheppard, M. C.; Ramsden, D. B.

    1985-01-01

    Results of thyroid function tests were analysed in 199 clinically euthyroid inpatients with normal serum thyroid stimulating hormone values. Serum total triiodothyronine was less than 1.25 nmol/l in 61.8% of samples, free triiodothyronine less than 3.9 pmol/l in 57.8%, total thyroxine less than 63 nmol/l in 21.1% and free thyroxine less than 9.5 pmol/l in 17.6%. In contrast, thyroxine binding globulin ratio was below normal (less than 5) in only 5 samples. A significant positive correlation (P less than 0.001) of serum free thyroxine with total thyroxine, thyroxine/thyroxine binding globulin ratio and free triiodothyronine was present as well as a significant negative correlation (P less than 0.001) with serum thyroid stimulating hormone. There was no correlation of free thyroxine measurements with serum albumin or non-esterified fatty acid concentrations. Although serum free thyroxine is low in a number of patients with non-thyroidal illnesses, this does not appear to be due to a rise in non-esterified fatty acids or a fall in albumin as has been proposed. Serum thyroid stimulating hormone measurements are essential to confirm the diagnosis of hypothyroidism in such subjects. PMID:4070117

  2. Inverter testing at Sandia National Laboratories

    SciTech Connect

    Ginn, J.W.; Bonn, R.H.; Sittler, G.

    1997-04-01

    Inverters are key building blocks of photovoltaic (PV) systems that produce ac power. The balance of systems (BOS) portion of a PV system can account for up to 50% of the system cost, and its reliable operation is essential for a successful PV system. As part of its BOS program, Sandia National Laboratories (SNL) maintains a laboratory wherein accurate electrical measurements of power systems can be made under a variety of conditions. This paper outlines the work that is done in that laboratory.

  3. [Recent advances in immunologic laboratory testing for rheumatic diseases].

    PubMed

    Akahoshi, Tohru

    2004-09-01

    Immunologic laboratory tests serve critical roles in the care of patients with various rheumatic diseases. These tests can provide relevant information of rheumatic diseases based on their immunopathophysiological condition. Although immunologic laboratory tests are quite useful for the determination of diagnosis and the estimation of disease activity, organ involvement and prognosis, they are frequently misused and resulted in an inappropriate diagnosis and treatment. Appropriate use of immunologic laboratory tests and accurate clinical interpretation of the test results can prevent false diagnosis and unnecessary treatment. In order to improve clinical care of patients with rheumatic diseases, clinicians caring patients with rheumatic disease should recognize meanings, characteristics and limitations of each result of immunologic laboratory testing. This article reviewed recent advances in immunologic laboratory testing such as antinuclear antibody, anti-DNA antibody and anti-neutrophil cytoplasmic antibody, and introduced guidelines for these testing. These guidelines based on evidences of EBM may contribute to the appropriate use of immunologic laboratory tests for rheumatic diseases.

  4. Interference of medical contrast media on laboratory testing.

    PubMed

    Lippi, Giuseppe; Daves, Massimo; Mattiuzzi, Camilla

    2014-01-01

    The use of contrast media such as organic iodine molecules and gadolinium contrast agents is commonplace in diagnostic imaging. Although there is widespread perception that side effects and drug interactions may be the leading problems caused by these compounds, various degrees of interference with some laboratory tests have been clearly demonstrated. Overall, the described interference for iodinate contrast media include inappropriate gel barrier formation in blood tubes, the appearance of abnormal peaks in capillary zone electrophoresis of serum proteins, and a positive bias in assessment of cardiac troponin I with one immunoassay. The interference for gadolinium contrast agents include negative bias in calcium assessment with ortho-cresolphthalein colorimetric assays and occasional positive bias using some Arsenazo reagents, negative bias in measurement of angiotensin converting enzyme (ACE) and zinc (colorimetric assay), as well as positive bias in creatinine (Jaffe reaction), total iron binding capacity (TIBC, ferrozine method), magnesium (calmagite reagent) and selenium (mass spectrometry) measurement. Interference has also been reported in assessment of serum indices, pulse oximetry and methaemoglobin in samples of patients receiving Patent Blue V. Under several circumstances the interference was absent from manufacturer-supplied information and limited to certain type of reagents and/or analytes, so that local verification may be advisable to establish whether or not the test in use may be biased. Since the elimination half-life of these compounds is typically lower than 2 h, blood collection after this period may be a safer alternative in patients who have received contrast media for diagnostic purposes.

  5. 5. AERIAL PHOTO OF THE COMPONENTS TEST LABORATORY DURING THE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. AERIAL PHOTO OF THE COMPONENTS TEST LABORATORY DURING THE CONSTRUCTION OF THE EAST TEST AREA. 1955, FRED ORDWAY COLLECTION, U.S. SPACE AND ROCKET CENTER, HUNTSVILLE, AL. - Marshall Space Flight Center, East Test Area, Components Test Laboratory, Huntsville, Madison County, AL

  6. 10. Interior view of control room in Components Test Laboratory ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    10. Interior view of control room in Components Test Laboratory (T-27), looking east. The control room is located in the center of the building and abuts the Test Cell 8, 9, and 10 and equipment room wings. Photograph shows upgraded instrumentation, piping, and technological modifications installed in 1997-99 to accommodate component testing requirements for the Atlas V missile. - Air Force Plant PJKS, Systems Integration Laboratory, Components Test Laboratory, Waterton Canyon Road & Colorado Highway 121, Lakewood, Jefferson County, CO

  7. Mutant laboratory mice with abnormalities in hair follicle morphogenesis, cycling, and/or structure: an update.

    PubMed

    Nakamura, Motonobu; Schneider, Marlon R; Schmidt-Ullrich, Ruth; Paus, Ralf

    2013-01-01

    Human hair disorders comprise a number of different types of alopecia, atrichia, hypotrichosis, distinct hair shaft disorders as well as hirsutism and hypertrichosis. Their causes vary from genodermatoses (e.g. hypotrichoses) via immunological disorders (e.g. alopecia areata, autoimmune cicatrical alopecias) to hormone-dependent abnormalities (e.g. androgenetic alopecia). A large number of spontaneous mouse mutants and genetically engineered mice develop abnormalities in hair follicle morphogenesis, cycling, and/or hair shaft formation, whose analysis has proven invaluable to define the molecular regulation of hair growth, ranging from hair follicle development, and cycling to hair shaft formation and stem cell biology. Also, the accumulating reports on hair phenotypes of mouse strains provide important pointers to better understand the molecular mechanisms underlying human hair growth disorders. Since numerous new mouse mutants with a hair phenotype have been reported since the publication of our earlier review on this matter a decade ago, we present here an updated, tabulated mini-review. The updated annotated tables list a wide selection of mouse mutants with hair growth abnormalities, classified into four categories: Mutations that affect hair follicle (1) morphogenesis, (2) cycling, (3) structure, and (4) mutations that induce extrafollicular events (for example immune system defects) resulting in secondary hair growth abnormalities. This synthesis is intended to provide a useful source of reference when studying the molecular controls of hair follicle growth and differentiation, and whenever the hair phenotypes of a newly generated mouse mutant need to be compared with existing ones.

  8. 42 CFR 493.1487 - Condition: Laboratories performing high complexity testing; testing personnel.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... testing; testing personnel. 493.1487 Section 493.1487 Public Health CENTERS FOR MEDICARE & MEDICAID... REQUIREMENTS Personnel for Nonwaived Testing Laboratories Performing High Complexity Testing § 493.1487 Condition: Laboratories performing high complexity testing; testing personnel. The laboratory has...

  9. 42 CFR 493.1487 - Condition: Laboratories performing high complexity testing; testing personnel.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... testing; testing personnel. 493.1487 Section 493.1487 Public Health CENTERS FOR MEDICARE & MEDICAID... REQUIREMENTS Personnel for Nonwaived Testing Laboratories Performing High Complexity Testing § 493.1487 Condition: Laboratories performing high complexity testing; testing personnel. The laboratory has...

  10. 42 CFR 493.1487 - Condition: Laboratories performing high complexity testing; testing personnel.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... testing; testing personnel. 493.1487 Section 493.1487 Public Health CENTERS FOR MEDICARE & MEDICAID... REQUIREMENTS Personnel for Nonwaived Testing Laboratories Performing High Complexity Testing § 493.1487 Condition: Laboratories performing high complexity testing; testing personnel. The laboratory has...

  11. 42 CFR 493.1487 - Condition: Laboratories performing high complexity testing; testing personnel.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... testing; testing personnel. 493.1487 Section 493.1487 Public Health CENTERS FOR MEDICARE & MEDICAID... REQUIREMENTS Personnel for Nonwaived Testing Laboratories Performing High Complexity Testing § 493.1487 Condition: Laboratories performing high complexity testing; testing personnel. The laboratory has...

  12. New technologies to improve laboratory testing

    NASA Astrophysics Data System (ADS)

    Burtis, C. A.

    Several core technologies that are having, or will have, an impact on the clinical laboratory are discussed. These include instrument-related technologies such as computer technology, chemometrics, robotics, sensors, and biological technologies such as cell fusion and recombinant DNA.

  13. [How do hospital clinical laboratories and laboratory testing companies cooperate and build reciprocal relations?].

    PubMed

    Kawano, Seiji

    2014-12-01

    As the 2nd Joint Symposium of the Japanese Society of Laboratory Medicine and the Japanese Association of Laboratory Pathologists, the symposium on clinical test out-sourcing and branch laboratories was held at the 60th General Meeting of the Japanese Society of Laboratory Medicine on November 2nd, 2013 in Kobe. For the symposium, we conducted a questionnaire survey on the usage of clinical test out-sourcing and the introduction of branch laboratories to clinical laboratories of Japanese university hospitals, both private and public, between July 25th and August 20th, 2013. Seventy-two hospitals responded to the questionnaire survey, consisting of 41 public medical school hospitals and 31 private ones. According to the survey, the selection of each clinical test for out-sourcing was mainly determined by the capacities of hospital clinical laboratories and their equipment, as well as the profitability of each test. The main concerns of clinical laboratory members of university hospitals involved the continuity of measurement principles, traceability, and standardization of reference values for each test. They strongly requested the interchangeability and computerization of test data between laboratory testing companies. A branch laboratory was introduced to six hospitals, all of which were private medical college hospitals, out of 72 university hospitals, and eight of the other hospitals were open to its introduction. The merits and demerits of introducing a branch laboratory were also discussed. (Review).

  14. 19 CFR 151.71 - Laboratory testing for clean yield.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... OF THE TREASURY (CONTINUED) EXAMINATION, SAMPLING, AND TESTING OF MERCHANDISE Wool and Hair § 151.71... director. (b) Notification to importer. Where samples of wool or hair have been tested in a Customs... laboratory test is not feasible, the wool or hair may be retested by a commercial laboratory in...

  15. 19 CFR 151.71 - Laboratory testing for clean yield.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... OF THE TREASURY (CONTINUED) EXAMINATION, SAMPLING, AND TESTING OF MERCHANDISE Wool and Hair § 151.71... director. (b) Notification to importer. Where samples of wool or hair have been tested in a Customs... laboratory test is not feasible, the wool or hair may be retested by a commercial laboratory in...

  16. 19 CFR 151.71 - Laboratory testing for clean yield.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... OF THE TREASURY (CONTINUED) EXAMINATION, SAMPLING, AND TESTING OF MERCHANDISE Wool and Hair § 151.71... director. (b) Notification to importer. Where samples of wool or hair have been tested in a Customs... laboratory test is not feasible, the wool or hair may be retested by a commercial laboratory in...

  17. 19 CFR 151.71 - Laboratory testing for clean yield.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... OF THE TREASURY (CONTINUED) EXAMINATION, SAMPLING, AND TESTING OF MERCHANDISE Wool and Hair § 151.71... director. (b) Notification to importer. Where samples of wool or hair have been tested in a Customs... laboratory test is not feasible, the wool or hair may be retested by a commercial laboratory in...

  18. 19 CFR 151.71 - Laboratory testing for clean yield.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... OF THE TREASURY (CONTINUED) EXAMINATION, SAMPLING, AND TESTING OF MERCHANDISE Wool and Hair § 151.71... director. (b) Notification to importer. Where samples of wool or hair have been tested in a Customs... laboratory test is not feasible, the wool or hair may be retested by a commercial laboratory in...

  19. 7 CFR 58.523 - Laboratory and quality control tests.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 3 2011-01-01 2011-01-01 false Laboratory and quality control tests. 58.523 Section... Service 1 Operations and Operating Procedures § 58.523 Laboratory and quality control tests. (a) Quality control tests shall be made on samples as often as necessary to determine the shelf-life and stability...

  20. 7 CFR 58.523 - Laboratory and quality control tests.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Laboratory and quality control tests. 58.523 Section... Service 1 Operations and Operating Procedures § 58.523 Laboratory and quality control tests. (a) Quality control tests shall be made on samples as often as necessary to determine the shelf-life and stability...

  1. 7 CFR 58.523 - Laboratory and quality control tests.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 3 2012-01-01 2012-01-01 false Laboratory and quality control tests. 58.523 Section... Service 1 Operations and Operating Procedures § 58.523 Laboratory and quality control tests. (a) Quality control tests shall be made on samples as often as necessary to determine the shelf-life and stability...

  2. 7 CFR 58.523 - Laboratory and quality control tests.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 3 2013-01-01 2013-01-01 false Laboratory and quality control tests. 58.523 Section... Service 1 Operations and Operating Procedures § 58.523 Laboratory and quality control tests. (a) Quality control tests shall be made on samples as often as necessary to determine the shelf-life and stability...

  3. 7 CFR 58.523 - Laboratory and quality control tests.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 3 2014-01-01 2014-01-01 false Laboratory and quality control tests. 58.523 Section... Service 1 Operations and Operating Procedures § 58.523 Laboratory and quality control tests. (a) Quality control tests shall be made on samples as often as necessary to determine the shelf-life and stability...

  4. Transportable Emissions Testing Laboratory for Alternative Vehicles Emissions Testing

    SciTech Connect

    Clark, Nigel

    2012-01-31

    The overall objective of this project was to perform research to quantify and improve the energy efficiency and the exhaust emissions reduction from advanced technology vehicles using clean, renewable and alternative fuels. Advanced vehicle and alternative fuel fleets were to be identified, and selected vehicles characterized for emissions and efficiency. Target vehicles were to include transit buses, school buses, vocational trucks, delivery trucks, and tractor-trailers. Gaseous species measured were to include carbon monoxide, carbon dioxide, oxides of nitrogen, hydrocarbons, and particulate matter. An objective was to characterize particulate matter more deeply than by mass. Accurate characterization of efficiency and emissions was to be accomplished using a state-of-the-art portable emissions measurement system and an accompanying chassis dynamometer available at West Virginia University. These two units, combined, are termed the Transportable Laboratory. An objective was to load the vehicles in a real-world fashion, using coast down data to establish rolling resistance and wind drag, and to apply the coast down data to the dynamometer control. Test schedules created from actual vehicle operation were to be employed, and a specific objective of the research was to assess the effect of choosing a test schedule which the subject vehicle either cannot follow or can substantially outperform. In addition the vehicle loading objective was to be met better with an improved flywheel system.

  5. 9. Exterior view, Test Cell 7, Systems Integration Laboratory Building ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. Exterior view, Test Cell 7, Systems Integration Laboratory Building (T-28), looking southwest. The enclosure discussed in CO-88-B-8 is at the right. - Air Force Plant PJKS, Systems Integration Laboratory, Systems Integration Laboratory Building, Waterton Canyon Road & Colorado Highway 121, Lakewood, Jefferson County, CO

  6. Methods for Testing the Mars Science Laboratory's Landing Radar

    NASA Technical Reports Server (NTRS)

    Chapin, Elaine; Grando, Maurio B.; Hamilton, Gary A.; Pak, Kyung S.; Pollard, Brian D.; Shaffer, Scott J.; Wu, Chialin

    2013-01-01

    The Mars Science Laboratory's rover named Curiosity successfully landed on Mars on August 6, 2012. One component of the Mars Science Laboratory (MSL) Entry, Descent, and Landing (EDL) system was the Terminal Descent Sensor (TDS) landing radar. In this paper we describe laboratory testing of this radar performed before launch.

  7. Workgroup for Hydraulic laboratory Testing and Verification of Hydroacoustic Instrumentation

    USGS Publications Warehouse

    Fulford, Janice M.; Armstrong, Brandy N.; Thibodeaux, Kirk G.

    2015-01-01

    An international workgroup was recently formed for hydraulic laboratory testing and verification of hydroacoustic instrumentation used for water velocity measurements. The activities of the workgroup have included one face to face meeting, conference calls and an inter-laboratory exchange of two acoustic meters among participating laboratories. Good agreement was found among four laboratories at higher tow speeds and poorer agreement at the lowest tow speed.

  8. Comparative observation of skeletal-dental abnormalities in wild, domestic, and laboratory rabbits.

    PubMed

    Okuda, Ayako; Hori, Yutaka; Ichihara, Nobutsune; Asari, Masao; Wiggs, Robert B

    2007-12-01

    Dietary habits must be considered as one of the major potential factors resulting in acquired malocclusions in rabbits. Although the dentition of the wild rabbit and the domesticated laboratory rabbit are basically identical, dietary habits are noticeably different. Therefore, the prevalence of tooth problems between these lagomorph species were investigated anatomically and radiographically. Mean measurements of the skull and dental arches suggested that wild rabbits have slightly shorter and wider skulls and dental arches compared with domestic laboratory rabbits. Root elongation of incisors and check teeth, and periodontal disease were more frequently observed in domestic laboratory rabbits. Diagnostic radiographs from domestic pet rabbits showed relatively higher crowns, severe root elongation, and advanced periodontitis. These results do not provide definitive evidence that dietary habits cause malocclusions, however they suggest that diet is a major factor in the initiation of malocclusions in rabbits.

  9. Predicting Tests Ordered in Hospital Laboratories using Generalized Linear Modeling.

    PubMed

    Leaven, Laquanda T

    2016-01-01

    Laboratory services in healthcare systems play a vital role in inpatient care. Most hospital laboratories are facing the challenge of reducing cost and improving service quality. The author focuses on identifying test order patterns in a laboratory for a large urban hospital. The data collected from this facility consists of all tests ordered over a three-month time frame and contains test orders for approximately 17,500 patients. Poisson and negative binomial regression models are used to determine how well patient characteristics (patient length of stay and the medical units in which patients are placed) will predict the number of tests being ordered. The test order prediction model developed in this study will aid the management and phlebotomists in the hospital laboratory in securing methods to satisfy the test order demand. By implementing the recommendations of this study, hospital laboratories should see significant improvements in phlebotomist productivity and resource utilization, implementation of which could result in cost savings.

  10. Test and analysis on the abnormal noise of the ultrasonic detection device

    NASA Astrophysics Data System (ADS)

    Li, Guangya; Yang, Mingliang; Wang, Mingquan; Tan, Qiulin; Duan, Nengquan

    2014-03-01

    For the phenomenon that the abnormal noise appear suddenly when the ultrasonic detection device works at the rate of 800mm/min, a vibration testing for this detection device is designed and investigated in this paper. Deep analysis are carried out based on the experimental modal analysis method of point excitation with multiple point three vectors in response and spectrum analysis method. The analysis results demonstrate the main reasons of the abnormal noise, which is due to the resonance between the motor and the ultrasonic station.

  11. 19 CFR 151.54 - Testing by Customs laboratory.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Testing by Customs laboratory. 151.54 Section 151.54 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF... Other Metal-Bearing Materials § 151.54 Testing by Customs laboratory. Samples taken in accordance...

  12. 7 CFR 58.442 - Laboratory and quality control tests.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 3 2014-01-01 2014-01-01 false Laboratory and quality control tests. 58.442 Section... Service 1 Operations and Operating Procedures § 58.442 Laboratory and quality control tests. (a) Chemical... Methods or by other methods giving equivalent results. (b) Weight or volume control....

  13. 7 CFR 58.442 - Laboratory and quality control tests.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 3 2011-01-01 2011-01-01 false Laboratory and quality control tests. 58.442 Section... Service 1 Operations and Operating Procedures § 58.442 Laboratory and quality control tests. (a) Chemical... Methods or by other methods giving equivalent results. (b) Weight or volume control....

  14. 7 CFR 58.442 - Laboratory and quality control tests.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 3 2012-01-01 2012-01-01 false Laboratory and quality control tests. 58.442 Section... Service 1 Operations and Operating Procedures § 58.442 Laboratory and quality control tests. (a) Chemical... Methods or by other methods giving equivalent results. (b) Weight or volume control....

  15. 7 CFR 58.442 - Laboratory and quality control tests.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 3 2013-01-01 2013-01-01 false Laboratory and quality control tests. 58.442 Section... Service 1 Operations and Operating Procedures § 58.442 Laboratory and quality control tests. (a) Chemical... Methods or by other methods giving equivalent results. (b) Weight or volume control....

  16. 7 CFR 58.442 - Laboratory and quality control tests.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Laboratory and quality control tests. 58.442 Section... Service 1 Operations and Operating Procedures § 58.442 Laboratory and quality control tests. (a) Chemical... Methods or by other methods giving equivalent results. (b) Weight or volume control....

  17. Total laboratory automation: Do stat tests still matter?

    PubMed

    Dolci, Alberto; Giavarina, Davide; Pasqualetti, Sara; Szőke, Dominika; Panteghini, Mauro

    2017-04-05

    During the past decades the healthcare systems have rapidly changed and today hospital care is primarily advocated for critical patients and acute treatments, for which laboratory test results are crucial and need to be always reported in predictably short turnaround time (TAT). Laboratories in the hospital setting can face this challenge by changing their organization from a compartmentalized laboratory department toward a decision making-based laboratory department. This requires the implementation of a core laboratory, that exploits total laboratory automation (TLA) using technological innovation in analytical platforms, track systems and information technology, including middleware, and a number of satellite specialized laboratory sections cooperating with care teams for specific medical conditions. In this laboratory department model, the short TAT for all first-line tests performed by TLA in the core laboratory represents the key paradigm, where no more stat testing is required because all samples are handled in real-time and (auto)validated results dispatched in a time that fulfills clinical needs. To optimally reach this goal, laboratories should be actively involved in managing all the steps covering the total examination process, speeding up also extra-laboratory phases, such sample delivery. Furthermore, to warrant effectiveness and not only efficiency, all the processes, e.g. specimen integrity check, should be managed by middleware through a predefined set of rules defined in light of the clinical governance.

  18. Laboratory Tests - Multiple Languages: MedlinePlus

    MedlinePlus

    ... Arabic (العربية) Chinese - Simplified (简体中文) Chinese - Traditional (繁體中文) French (français) Hindi (हिन्दी) Japanese (日本語) Khmer (Khmer) ... Chinese - Traditional) PDF Chinese Community Health Resource Center French (français) 24-Hour Urine Test Test d'urine ...

  19. Human Papillomavirus Laboratory Testing: the Changing Paradigm

    PubMed Central

    2016-01-01

    SUMMARY High-risk human papillomaviruses (HPVs) cause essentially all cervical cancers, most anal and oropharyngeal cancers, and some vaginal, vulvar, and penile cancers. Improved understanding of the pathogenesis of infection and the availability of newer tests are changing the approach to screening and diagnosis. Molecular tests to detect DNA from the most common high-risk HPVs are FDA approved for use in conjunction with cytology in cervical cancer screening programs. More-specific tests that detect RNA from high-risk HPV types are now also available. The use of molecular tests as the primary screening tests is being adopted in some areas. Genotyping to identify HPV16 and -18 has a recommended role in triaging patients for colposcopy who are high-risk HPV positive but have normal cytology. There are currently no recommended screening methods for anal, vulvar, vaginal, penile, or oropharyngeal HPV infections. HPV testing has limited utility in patients at high risk for anal cancer, but p16 immunohistochemistry is recommended to clarify lesions in tissue biopsy specimens that show moderate dysplasia or precancer mimics. HPV testing is recommended for oropharyngeal squamous cell tumors as a prognostic indicator. Ongoing research will help to improve the content of future guidelines for screening and diagnostic testing. PMID:26912568

  20. Contextualizing Laboratory Administered Aural Comprehension Tests

    ERIC Educational Resources Information Center

    Seliger, Herbert W.; Whiteson, Valerie

    1975-01-01

    An experimental test consisting of dialogue with intermittent pauses for responses and a white noise accompaniment was given to non-English speakers who were candidates for admission to the English Department at Bar Ilan University in order to evaluate aural comprehension. Development of the test and results are reported. (RM)

  1. A Cautionary Note: Ceriodaphnia dubia Inter-Laboratory Test Variability.

    PubMed

    Pacholski, Laura; Chapman, Peter; Hood, Alexandra; Peters, Michelle

    2017-01-01

    An inter-laboratory comparison of the three-brood survival and reproduction Ceriodaphnia dubia toxicity test was conducted involving three toxicity testing laboratories. This comparison was initiated due to sporadic toxicity with this test related to discharge of a mine effluent, which some regulators believed indicated adverse effects in the receiving environment. One mine effluent and two receiving water samples were evaluated. There were no adverse effects on C. dubia survival in any tests. However, sublethal effects on reproduction (i.e., the IC25; the concentration that causes a 25 % inhibitory effect in the measured sublethal endpoint) ranged from 35 % to >100 % among all test treatments. All laboratories were certified for this test and followed established procedures. Dilute mineral water appears to be the best medium for culturing, dilution, and control water. Variability in the C. dubia laboratory toxicity test should not be mistaken for adverse effects in receiving environments.

  2. Laboratory results of the AOF system testing

    NASA Astrophysics Data System (ADS)

    Kolb, Johann; Madec, Pierre-Yves; Arsenault, Robin; Oberti, Sylvain; Paufique, Jérôme; La Penna, Paolo; Ströbele, Stefan; Donaldson, Robert; Soenke, Christian; Suárez Valles, Marcos; Kiekebusch, Mario; Argomedo, Javier; Le Louarn, Miska; Vernet, Elise; Haguenauer, Pierre; Duhoux, Philippe; Aller-Carpentier, Emmanuel; Valenzuela, Jose Javier; Guerra, Juan Carlos

    2016-07-01

    For two years starting in February 2014, the AO modules GRAAL for HAWK-I and GALACSI for MUSE of the Adaptive Optics Facility project have undergone System Testing at ESO's Headquarters. They offer four different modes: NGS SCAO, LGS GLAO in the IR, LGS GLAO and LTAO in the visible. A detailed characterization of those modes was made possible by the existence of ASSIST, a test bench emulating an adaptive VLT including the Deformable Secondary Mirror, a star simulator and turbulence generator and a VLT focal plane re-imager. This phase aimed at validating all the possible components and loops of the AO modules before installation at the actual VLT that comprises the added complexity of real LGSs, a harsher non-reproducible environment and the adaptive telescope control. In this paper we present some of the major results obtained and challenges encountered during the phase of System Tests, like the preparation of the Acquisition sequence, the testing of the Jitter loop, the performance optimization in GLAO and the offload of low-order modes from the DSM to the telescope (restricted to the M2 hexapod). The System Tests concluded with the successful acceptance, shipping, installation and first commissioning of GRAAL in 2015 as well as the acceptance and shipping of GALACSI, ready for installation and commissioning early 2017.

  3. Laboratory Characterization Tests for Antimisting Fuel.

    DTIC Science & Technology

    1987-03-01

    58 2.11 Viscosity and Viscosity Ratio Test 61 2.12 Solids Test Method 67 2.13 Water Content Determination 76 2.14 Glycol Measurement 83 2.15 Amine...2.34 Uptake of Water by FM-9 AMK 77 2.35 Apparatus for Determination of Water by Karl Fischer Reagent 78 2.36 Titration Assembly Electrode 80 2.37...Die Swell 0 N 9 Low Temp Gel Formation o 10 Inertial Rheometric Pump o 11 Viscosity and Viscosity Ratio o 12 Solids 0 13 Water Content Determination 0

  4. Laboratory test of a pyramid wavefront sensor

    NASA Astrophysics Data System (ADS)

    Esposito, Simone; Feeney, Orla; Riccardi, Armando

    2000-07-01

    A laboratory characterization of a new wavefront sensor for adaptive optics applications called a pyramid sensor is presented. This characterization is aimed at establishing the sensor accuracy and sensitivity. To investigate the operation of the sensor in low and high order correction adaptive optics systems, its behavior for different amplitudes of incoming wavefront aberrations is studied. The sensor characterization is carried out using a two arm optical set-up that allows the comparison of the PS measurements with those of a commercial Fizeau interferometer. This is done when a certain aberration is introduced into the optical path of both instruments via a deformable mirror. The experimental data are analyzed and discussed using both geometrical and diffractive optics theory. The closed loop sensor accuracy is investigated experimentally and demonstrates closed loop wavefront correction down to 30 nm root mean square for starting aberrations whose root mean square ranges from 170 nm to 300 nm. Modal noise propagation coefficients are determined and are compared with Shack-Hartmann sensor coefficients.

  5. Prenatal diagnosis: choices women make about pursuing testing and acting on abnormal results.

    PubMed

    Pryde, P G; Drugan, A; Johnson, M P; Isada, N B; Evans, M I

    1993-09-01

    Liberalization of abortion laws in several US states (e.g., New York and California) coincided with the development of prenatal techniques, which diagnose chromosomal abnormalities and biochemical disorders. Increased use of prenatal diagnostic services has not been accompanied by adequate examination of the decision making process women undergo when contemplating prenatal diagnosis, pregnancy termination, or experimental fetal therapy. The limited literature exploring these issues indicates that many women do not know as much as possible about the health of their fetus. Women who are at risk of abnormal pregnancy tend to become distressed and willing to accept invasive testing, even when they know the significant, albeit low, risks of such testing. Women's perceptions of risk, which stem from complex psychologic-phenomena, are likely to be very inconsistent with objective reality. Neither counseling nor education can easily change these misperceptions. Nevertheless, counseling can at least alter misperceptions enough so they move closer to objective reality. On the other hand, counseling can sway perceptions and choices made based on these perceptions. Decision making is even more complex and emotional when women encounter abnormalities. Considerable social, moral, and psychologic factors influence this process, making this a very problematic area to study. Almost all women who carry an abnormal fetus with a very serious prognosis and a high degree of diagnostic certainty chose to terminate the pregnancy. The decision is much more difficult for women carrying a fetus with less diagnostic or prognostic certainty. Insufficient data exists to determine how they handle these management decisions. Women tend to opt for abortion in cases of chromosomal abnormalities, regardless of the severity or certainty of the outcome. Women carrying a fetus with anatomic disorders with prognostic uncertainty or less severity choose to abort at lower rates. More research is needed to

  6. Centrifugal contractors for laboratory-scale solvent extraction tests

    SciTech Connect

    Leonard, R.A.; Chamberlain, D.B.; Conner, C.

    1995-12-31

    A 2-cm contactor (minicontactor) was developed and used at Argonne National Laboratory for laboratory-scale testing of solvent extraction flowsheets. This new contactor requires only 1 L of simulated waste feed, which is significantly less than the 10 L required for the 4-cm unit that had previously been used. In addition, the volume requirements for the other aqueous and organic feeds are reduced correspondingly. This paper (1) discusses the design of the minicontactor, (2) describes results from having applied the minicontactor to testing various solvent extraction flowsheets, and (3) compares the minicontactor with the 4-cm contactor as a device for testing solvent extraction flowsheets on a laboratory scale.

  7. Laboratory-scale integrated ARP filter test

    SciTech Connect

    Poirier, M.; Burket, P.

    2016-03-01

    The Savannah River Site (SRS) is currently treating radioactive liquid waste with the Actinide Removal Process (ARP) and the Modular Caustic Side Solvent Extraction Unit (MCU). Recently, the low filter flux through the ARP of approximately 5 gallons per minute has limited the rate at which radioactive liquid waste can be treated. Salt Batch 6 had a lower processing rate and required frequent filter cleaning. There is a desire to understand the causes of the low filter flux and to increase ARP/MCU throughput. This task attempted to simulate the entire ARP process, including multiple batches (5), washing, chemical cleaning, and blending the feed with heels and recycle streams. The objective of the tests was to determine whether one of these processes is causing excessive fouling of the crossflow or secondary filter. The authors conducted the tests with feed solutions containing 6.6 M sodium Salt Batch 6 simulant supernate with no MST.

  8. The Status of Spectral EEG Abnormality as a Diagnostic Test for Schizophrenia

    PubMed Central

    Boutros, Nash N.; Arfken, Cynthia; Galderisi, Silvana; Warrick, Joshua; Pratt, Garrett; Iacono, William

    2008-01-01

    Objective A literature review was conducted to ascertain whether or not EEG spectral abnormalities are consistent enough to warrant additional effort towards developing them into a clinical diagnostic test for schizophrenia. Methods Fifty three papers met criteria for inclusion into the review and 15 were included in a meta-analysis of the degree of significance of EEG deviations as compared to healthy controls. Studies were classified based on a 4-step approach based on guidelines for evaluating the clinical usefulness of a diagnostic test. Results Our review and meta-analysis revealed that most of the abnormalities are replicated in the expected directions with the most consistent results related to the increased preponderance of slow rhythms in schizophrenia patients. This effect remained consistent in un-medicated patients. Only a small number of studies provided data on the sensitivity and specificity of the findings in differentiating among the psychiatric disorders that frequently appear on the same differential diagnostic list as schizophrenia (step 3 studies). No multicenter studies using standardized assessment criteria were found (step 4 studies). Conclusions Additional Step 3 and Step 4 studies are needed to draw conclusions on the usefulness of EEG spectral abnormalities as a diagnostic test for schizophrenia PMID:18160260

  9. 42 CFR 493.1441 - Condition: Laboratories performing high complexity testing; laboratory director.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 5 2013-10-01 2013-10-01 false Condition: Laboratories performing high complexity testing; laboratory director. 493.1441 Section 493.1441 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION...

  10. 42 CFR 493.1441 - Condition: Laboratories performing high complexity testing; laboratory director.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 5 2012-10-01 2012-10-01 false Condition: Laboratories performing high complexity testing; laboratory director. 493.1441 Section 493.1441 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION...

  11. 42 CFR 493.1441 - Condition: Laboratories performing high complexity testing; laboratory director.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 5 2011-10-01 2011-10-01 false Condition: Laboratories performing high complexity testing; laboratory director. 493.1441 Section 493.1441 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION...

  12. 42 CFR 493.1441 - Condition: Laboratories performing high complexity testing; laboratory director.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 5 2010-10-01 2010-10-01 false Condition: Laboratories performing high complexity testing; laboratory director. 493.1441 Section 493.1441 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION...

  13. Analysis and Test Support for Phillips Laboratory Precision Structures

    DTIC Science & Technology

    1998-11-01

    Air Force Research Laboratory ( AFRL ), Phillips Research Site . Task objectives centered...around analysis and structural dynamic test support on experiments within the Space Vehicles Directorate at Kirtland Air Force Base. These efforts help...support for Phillips Laboratory Precision Structures." Mr. James Goodding of CSA Engineering was the principal investigator for this task. Mr.

  14. Draft Test Guideline: Generic Freshwater Microcosm Test, Laboratory

    EPA Pesticide Factsheets

    The following draft test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review.

  15. Draft Test Guideline: Site-Specific Aquatic Microcosm Test, Laboratory

    EPA Pesticide Factsheets

    The following draft test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review.

  16. Electronic Systems Test Laboratory (ESTL) User Test Planning Guide

    NASA Technical Reports Server (NTRS)

    Robinson, Neil

    2011-01-01

    Test process, milestones and inputs are unknowns to first-time users of the ESTL. The User Test Planning Guide aids in establishing expectations for both NASA and non-NASA facility customers. The potential audience for this guide includes both internal and commercial spaceflight hardware/software developers. It is intended to assist their test engineering personnel in test planning and execution. Material covered includes a roadmap of the test process, roles and responsibilities of facility and user, major milestones, facility capabilities, and inputs required by the facility. Samples of deliverables, test article interfaces, and inputs necessary to define test scope, cost, and schedule are included as an appendix to the guide.

  17. Structures Test Laboratory (STL). User Test Planning Guide

    NASA Technical Reports Server (NTRS)

    Zipay, John J.

    2011-01-01

    Test process, milestones and inputs are unknowns to first-time users of the STL. The User Test Planning Guide aids in establishing expectations for both NASA and non-NASA facility customers. The potential audience for this guide includes both internal and commercial spaceflight hardware/software developers. It is intended to assist their test engineering personnel in test planning and execution. Material covered includes a roadmap of the test process, roles and responsibilities of facility and user, major milestones, facility capabilities, and inputs required by the facility. Samples of deliverables, test article interfaces, and inputs necessary to define test scope, cost, and schedule are included as an appendix to the guide.

  18. Bilaterally Abnormal Head Impulse Tests Indicate a Large Cerebellopontine Angle Tumor

    PubMed Central

    Kim, Hyo-Jung; Park, Seong-Ho; Koo, Ja Won; Kim, Chae-Yong; Kim, Young-Hoon; Han, Jung Ho

    2016-01-01

    Background and Purpose Tumors involving the cerebellopontine angle (CPA) pose a diagnostic challenge due to their diverse manifestations. Head impulse tests (HITs) have been used to evaluate vestibular function, but few studies have explored the head impulse gain of the vestibulo-ocular reflex (VOR) in patients with a vestibular schwannoma. This study tested whether the head impulse gain of the VOR is an indicator of the size of a unilateral CPA tumor. Methods Twenty-eight patients (21 women; age=64±12 years, mean±SD) with a unilateral CPA tumor underwent a recording of the HITs using a magnetic search coil technique. Patients were classified into non-compressing (T1-T3) and compressing (T4) groups according to the Hannover classification. Results Most (23/28, 82%) of the patients showed abnormal HITs for the semicircular canals on the lesion side. The bilateral abnormality in HITs was more common in the compressing group than the non-compressing group (80% vs. 8%, Pearson's chi-square test: p<0.001). The tumor size was inversely correlated with the head impulse gain of the VOR in either direction. Conclusions Bilaterally abnormal HITs indicate that a patient has a large unilateral CPA tumor. The abnormal HITs in the contralesional direction may be explained either by adaptation or by compression and resultant dysfunction of the cerebellar and brainstem structures. The serial evaluation of HITs may provide information on tumor growth, and thereby reduce the number of costly brain scans required when following up patients with CPA tumors. PMID:26754780

  19. Bilateral Sensory Abnormalities in Patients with Unilateral Neuropathic Pain; A Quantitative Sensory Testing (QST) Study

    PubMed Central

    Konopka, Karl-Heinz; Harbers, Marten; Houghton, Andrea; Kortekaas, Rudie; van Vliet, Andre; Timmerman, Wia; den Boer, Johan A.; Struys, Michel M.R.F.; van Wijhe, Marten

    2012-01-01

    In patients who experience unilateral chronic pain, abnormal sensory perception at the non-painful side has been reported. Contralateral sensory changes in these patients have been given little attention, possibly because they are regarded as clinically irrelevant. Still, bilateral sensory changes in these patients could become clinically relevant if they challenge the correct identification of their sensory dysfunction in terms of hyperalgesia and allodynia. Therefore, we have used the standardized quantitative sensory testing (QST) protocol of the German Research Network on Neuropathic Pain (DFNS) to investigate somatosensory function at the painful side and the corresponding non-painful side in unilateral neuropathic pain patients using gender- and age-matched healthy volunteers as a reference cohort. Sensory abnormalities were observed across all QST parameters at the painful side, but also, to a lesser extent, at the contralateral, non-painful side. Similar relative distributions regarding sensory loss/gain for non-nociceptive and nociceptive stimuli were found for both sides. Once a sensory abnormality for a QST parameter at the affected side was observed, the prevalence of an abnormality for the same parameter at the non-affected side was as high as 57% (for Pressure Pain Threshold). Our results show that bilateral sensory dysfunction in patients with unilateral neuropathic pain is more rule than exception. Therefore, this phenomenon should be taken into account for appropriate diagnostic evaluation in clinical practice. This is particularly true for mechanical stimuli where the 95% Confidence Interval for the prevalence of sensory abnormalities at the non-painful side ranges between 33% and 50%. PMID:22629414

  20. Inter-laboratory validation of bioaccessibility testing for metals.

    PubMed

    Henderson, Rayetta G; Verougstraete, Violaine; Anderson, Kim; Arbildua, José J; Brock, Thomas O; Brouwers, Tony; Cappellini, Danielle; Delbeke, Katrien; Herting, Gunilla; Hixon, Greg; Odnevall Wallinder, Inger; Rodriguez, Patricio H; Van Assche, Frank; Wilrich, Peter; Oller, Adriana R

    2014-10-01

    Bioelution assays are fast, simple alternatives to in vivo testing. In this study, the intra- and inter-laboratory variability in bioaccessibility data generated by bioelution tests were evaluated in synthetic fluids relevant to oral, inhalation, and dermal exposure. Using one defined protocol, five laboratories measured metal release from cobalt oxide, cobalt powder, copper concentrate, Inconel alloy, leaded brass alloy, and nickel sulfate hexahydrate. Standard deviations of repeatability (sr) and reproducibility (sR) were used to evaluate the intra- and inter-laboratory variability, respectively. Examination of the sR:sr ratios demonstrated that, while gastric and lysosomal fluids had reasonably good reproducibility, other fluids did not show as good concordance between laboratories. Relative standard deviation (RSD) analysis showed more favorable reproducibility outcomes for some data sets; overall results varied more between- than within-laboratories. RSD analysis of sr showed good within-laboratory variability for all conditions except some metals in interstitial fluid. In general, these findings indicate that absolute bioaccessibility results in some biological fluids may vary between different laboratories. However, for most applications, measures of relative bioaccessibility are needed, diminishing the requirement for high inter-laboratory reproducibility in absolute metal releases. The inter-laboratory exercise suggests that the degrees of freedom within the protocol need to be addressed.

  1. Carrier screening for cystic fibrosis in US genetic testing laboratories: a survey of laboratory directors.

    PubMed

    Kaufman, D J; Katsanis, S H; Javitt, G H; Murphy, J A; Scott, J A; Hudson, K L

    2008-10-01

    Initial guidelines for cystic fibrosis (CF) carrier screening were issued in 2001 by the American College of Medical Genetics and the American College of Obstetricians and Gynecologists and updated in 2004. It is unknown how these guidelines have influenced laboratory practice. This study examined the uptake of two components of these guidelines for CF screening in genetic testing laboratories. A survey of directors of US genetic testing laboratories was conducted. Of 190 respondents, 178 answered questions about CF testing. Nearly half (49%) performed some type of DNA testing for CF; most of these (92%) performed CF carrier screening. Ten percent used a 23-mutation panel for CF screening. The results of 5T tests were reported as a reflex test by 79% of laboratories, while 8% always returned 5T results and 7% never returned them. Seven percent of laboratories adopted both guidelines, 80% adopted one of the two guidelines, and 13% had not adopted either recommendation, suggesting that factors other than clinical guidelines may influence laboratories' CF screening practices. Further studies are needed to determine whether the adoption of CF screening guidelines has significant clinical or economic effects on population-based CF screening programs.

  2. Evidence of abnormal esophageal motility in syndrome X by radionuclide esophageal transit test.

    PubMed

    Kao, C H; Hsieh, J F; Tsai, C S; Ho, Y J; Lee, J K

    2000-01-01

    In 30 patients with syndrome X, esophageal motility was evaluated by radionuclide esophageal transit test (RETT). Esophageal motility measurements included esophageal mean transit time (MTT), residual fraction (RF), and retrograde index (RI). In comparison with 25 age- and sex-matched healthy volunteers, 66% of the patients with syndrome X had abnormal RETT findings including 50% of cases with longer MTT, 50% of cases with higher RF, and 33% of cases with higher RI. In addition, the mean values of MTT, RF, and RI in patients with syndrome X were significantly higher than those of healthy volunteers. We conclude that abnormal esophageal motility occurred in a large portion of syndrome X patients based on an simple and noninvasive RETT.

  3. Statewide survey of laboratories performing Mycobacterium tuberculosis testing in Minnesota.

    PubMed Central

    Mills, W A; Besser-Wiek, J M; Osterholm, M T; MacDonald, K L

    1996-01-01

    Rapid and accurate laboratory detection and identification of Mycobacterium tuberculosis, particularly multidrug-resistant strains, is critical to both public health control measures and patient management. The authors surveyed microbiology laboratories to evaluate whether their methods met national guidelines. As needed, laboratories received individualized recommendations for improvement. The laboratories were resurveyed a year later to assess changes in methods. Current guidelines recommend fluorochrome acid-fast smears, broth cultures, identification by nucleic acid probe or BACTEC-NAP, and BACTEC primary susceptibility panels, which should include pyrazinamide. Of 27 laboratories performing acid-fast smears, 15 used fluorochrome methods. Six of 16 laboratories performing mycobacterial cultures used broth media. Of six laboratories performing species identification, five used nucleic acid probes or BACTEC-NAP. Of five laboratories evaluating drug sensitivity, two used BACTEC and two included pyrazinamide in their protocols. Overall, 24 (89%) laboratories needed improvements; a year later, 16 (67%) of those had altered their methods or made definite plans to do so. Survey results suggest that health departments can facilitate improvements in laboratory testing for pathogens of public health importance. PMID:8606914

  4. Immediate needs for MQA testing at state secondary calibration laboratories

    SciTech Connect

    Cline, R.

    1993-12-31

    The Calibration Laboratory attempts to provide services that satisfy the needs and requests for a variety of customers. New needs and requests have resulted in calibration of instrumentation outside the original laboratory designs. These tasks require several changes at the laboratory and a need for new support services, especially measurement quality assurance (MQA). The MQA tests are gamma (Cs-137) below 0.5 mrem (5{mu}Sv) per hour and x-ray kVp. Modification to the current gamma (Cs-137) MQA test is recommended because lower intensity fields are commonly measured.

  5. Recommended procedures for performance testing of radiobioassay laboratories: Volume 3, In vivo test phantoms

    SciTech Connect

    MacLellan, J.A.; Traub, R.J.

    1988-11-01

    Draft American National Standards Institute (ANSI) Standard N13.30 (Performance Criteria for Radiobioassay) was developed for the US Department of Energy and the US Nuclear Regulatory Commission to help ensure that bioassay laboratories provide accurate and consistent results. The draft standard describes the procedures necessary to establish a bioassay performance-testing laboratory and program. The bioassay performance-testing laboratory will conduct tests to evaluate the performance of service laboratories. Pacific Northwest Laboratory helped develop testing procedures as part of an effort to evaluate the draft ANSI N13.30 performance criteria by testing the existing measurement capabilities of various bioassay laboratories. This report recommends guidelines for the preparation, handling, storage, distribution, shipping, and documentation of test phantoms used for calibration of measurement systems for direct bioassay. The data base and recommended records system for documenting radiobioassay performance at the service laboratories are also presented.

  6. Limited Clinical Utility of Non-invasive Prenatal Testing for Subchromosomal Abnormalities

    PubMed Central

    Lo, Kitty K.; Karampetsou, Evangelia; Boustred, Christopher; McKay, Fiona; Mason, Sarah; Hill, Melissa; Plagnol, Vincent; Chitty, Lyn S.

    2016-01-01

    The use of massively parallel sequencing of maternal cfDNA for non-invasive prenatal testing (NIPT) of aneuploidy is widely available. Recently, the scope of testing has increased to include selected subchromosomal abnormalities, but the number of samples reported has been small. We developed a calling pipeline based on a segmentation algorithm for the detection of these rearrangements in maternal plasma. The same read depth used in our standard pipeline for aneuploidy NIPT detected 15/18 (83%) samples with pathogenic rearrangements > 6 Mb but only 2/10 samples with rearrangements < 6 Mb, unless they were maternally inherited. There were two false-positive calls in 534 samples with no known subchromosomal abnormalities (specificity 99.6%). Using higher read depths, we detected 29/31 fetal subchromosomal abnormalities, including the three samples with maternally inherited microduplications. We conclude that test sensitivity is a function of the fetal fraction, read depth, and size of the fetal CNV and that at least one of the two false negatives is due to a low fetal fraction. The lack of an independent method for determining fetal fraction, especially for female fetuses, leads to uncertainty in test sensitivity, which currently has implications for this technique’s future as a clinical diagnostic test. Furthermore, to be effective, NIPT must be able to detect chromosomal rearrangements across the whole genome for a very low false-positive rate. Because standard NIPT can only detect the majority of larger (>6 Mb) chromosomal rearrangements and requires knowledge of fetal fraction, we consider that it is not yet ready for routine clinical implementation. PMID:26708752

  7. Harmonization of laboratory testing - Current achievements and future strategies.

    PubMed

    Tate, Jillian R; Johnson, Roger; Barth, Julian; Panteghini, Mauro

    2014-05-15

    Harmonization in laboratory testing is more far-reaching than merely analytical harmonization. It includes all aspects of the total testing process from the "pre-pre-analytical" phase through analysis to the "post-post-analytical" phase. Harmonizing the pre-analytical phase requires use of standardized operating procedures for correct test selection, sample collection and handling, while standardized test terminology, and units and traceability to ISO standard 17511 are required to ensure equivalency of measurement results. Use of harmonized reference intervals and decision limits for analytes where platforms share allowable bias requirements will reduce inaccurate clinical interpretation and unnecessary laboratory testing. In the post-analytical phase, harmonized procedures for the management of critical laboratory test results are required to improve service quality and ensure patient safety. Monitoring of the outcomes of harmonization activities is through surveillance by external quality assessment schemes that use commutable materials and auditing of the "pre-pre-analytical" and "post-post-analytical" phases. Successful implementation of harmonization in laboratory testing requires input by all stakeholders, including the clinical laboratory community, diagnostics industry, clinicians, professional societies, IT providers, consumer advocate groups and governmental bodies.

  8. [Tilt test and orthostatic intolerance: abnormalities in the neural sympathetic response to gravitational stimulus].

    PubMed

    Furlan, R

    2001-05-01

    In the present manuscript the different methodologies aimed at assessing the autonomic profile in humans during a gravitational stimulus have been described. In addition, strengths and drawbacks of the tilt test in relation to occasional orthostatic intolerance were addressed. Finally, different autonomic abnormalities underlying occasional and chronic orthostatic intolerance syndromes have been schematically highlighted. The direct recording of the neural sympathetic discharge from the peroneal nerve (MSNA), in spite of its invasive nature, still represents the recognized reference to quantify the changes in the sympathetic activity to the vessels attending postural modifications. The increase of plasma norepinephrine during a tilt test is achieved by both an increase in plasma spillover and a concomitant decrease in systemic clearance. Changes in the indices of cardiac sympathetic and vagal modulation may also be quantified during a tilt test by power spectrum analysis of RR interval variability. The spectral markers of cardiac autonomic control, if evaluated concomitantly with MSNA, may contribute to assess abnormalities in the regional distribution of the sympathetic activity to the heart and the vessels. The capability of the tilt test of reproducing a vasovagal event or of inducing "false positive responses" seems to be markedly affected by the age, thus suggesting that additional or different etiopathogenetic mechanisms might be involved in the loss of consciousness in older as compared to younger subjects. In subjects suffering from occasional or habitual neurally mediated syncope an increase or, respectively, a decrease in cardiac and vascular sympathetic modulation has been documented before the loss of consciousness. In patients with pure autonomic failure, a global dysautonomia affecting both the sympathetic and the vagal modulation to the heart, seems to be present. In chronic orthostatic intolerance, the most common form of dysautonomia of young women

  9. Equipment qualification testing evaluation experiences at Sandia National Laboratories

    SciTech Connect

    Bustard, L.D.; Wyant, F.J.; Bonzon, L.L.; Gillen, K.T.

    1986-01-01

    The USNRC has sponsored a number of programs at Sandia National Laboratories specifically addressing safety-related equipment qualification. The most visible of these programs has been the Qualification Testing Evaluation (QTE) program. Other relevant programs have included the Equipment Qualification Methodology Research Test program (CAP). Over a ten year period these programs have collectively tested numerous types of safety-related equipment. Some insights and conclusions extracted from these testing experiences are summarized in this report.

  10. Reducing unnecessary inpatient laboratory testing in a teaching hospital.

    PubMed

    May, Todd A; Clancy, Mary; Critchfield, Jeff; Ebeling, Fern; Enriquez, Anita; Gallagher, Carmel; Genevro, Jim; Kloo, Jay; Lewis, Paul; Smith, Rita; Ng, Valerie L

    2006-08-01

    After an inpatient phlebotomy-laboratory test request audit for 2 general inpatient wards identified 5 tests commonly ordered on a recurring basis, a multidisciplinary committee developed a proposal to minimize unnecessary phlebotomies and laboratory tests by reconfiguring the electronic order function to limit phlebotomy-laboratory test requests to occur singly or to recur within one 24-hour window. The proposal was implemented in June 2003. Comparison of fiscal year volume data from before (2002-2003) and after (2003-2004) implementation revealed 72,639 (12.0%) fewer inpatient tests, of which 41,765 (57.5%) were related directly to decreases in the 5 tests frequently ordered on a recurring basis. Because the electronic order function changes did not completely eliminate unnecessary testing, we concluded that the decrease in inpatient testing represented a minimum amount of unnecessary inpatient laboratory tests. We also observed 17,207 (21.4%) fewer inpatient phlebotomies, a decrease sustained in fiscal year 20042005. Labor savings allowed us to redirect phlebotomists to our understaffed outpatient phlebotomy service.

  11. Package testing capabilities at the Pacific Northwest Laboratory

    SciTech Connect

    Taylor, J.M.

    1993-06-01

    The purpose of this paper is to describe the package testing capabilities at the Pacific Northwest Laboratory (PNL). In the past all of the package testing that was performed at PNL was done on prototype or mocked up radioactive material packaging. Presently, we are developing the capability to perform testing on non-radioactive material packaging. The testing on the non-radioactive material packaging will be done to satisfy the new performance oriented packaging requirements (DOT Docket HM-181, 1991). This paper describes the equipment used to perform the performance oriented packaging tests and also describes some testing capability for testing radioactive material packaging.

  12. Package testing capabilities at the Pacific Northwest Laboratory

    SciTech Connect

    Taylor, J.M.

    1993-01-01

    The purpose of this paper is to describe the package testing capabilities at the Pacific Northwest Laboratory (PNL). In the past all of the package testing that was performed at PNL was done on prototype or mocked up radioactive material packaging. Presently, we are developing the capability to perform testing on non-radioactive material packaging. The testing on the non-radioactive material packaging will be done to satisfy the new performance oriented packaging requirements (DOT Docket HM-181, 1991). This paper describes the equipment used to perform the performance oriented packaging tests and also describes some testing capability for testing radioactive material packaging.

  13. Predictive value of specific ultrasound findings when used as a screening test for abnormalities on VCUG

    PubMed Central

    Logvinenko, Tanya; Chow, Jeanne S.; Nelson, Caleb P.

    2015-01-01

    Summary Background Renal and bladder ultrasound (RBUS) is often used as an initial screening test for children after urinary tract infection (UTI). The 2011 AAP guidelines specifically recommend that RBUS be performed first, with voiding cystourethrogram (VCUG) to be performed only if the ultrasound is abnormal. While prior research has suggested that RBUS is neither sensitive nor specific for VCUG findings, such as vesicoureteral reflux (VUR), it is uncertain as to whether specific RBUS findings, alone or in combination, might make RBUS more useful as a predictor of VCUG abnormalities. Aims To evaluate the association of specific RBUS with VCUG findings, and determine whether predictive models that accurately predict patients at high risk of VCUG abnormalities, based on RBUS findings, can be constructed. Methods and study sample A total of 3995 patients were identified with VCUG and RBUS performed on the same day. The RBUS and VCUG reports were reviewed and the findings were classified. Analysis was limited to patients aged 0–60 months with no prior postnatal genitourinary imaging and no history of prenatal hydronephrosis. Analysis The associations between large numbers of specific RBUS findings with abnormalities seen on VCUG were investigated. Both multivariate logistic models and a neural network machine learning algorithms were constructed to evaluate the predictive power of RBUS for VCUG abnormalities (including VUR or bladder/urethral findings). Sensitivity, specificity, predictive values and area under receiving operating curves (AUROC) of RBUS for VCUG abnormalities were determined. Results A total of 2259 patients with UTI as the indication for imaging were identified. The RBUS was reported as “normal” in 75.0%. On VCUG, any VUR was identified in 41.7%, VUR grade >II in 20.9%, and VUR grade >III in 2.8%. Many individual RBUS findings were significantly associated with VUR on VCUG. Despite these strong univariate associations, multivariate modeling

  14. Field test of the Rapid Transuranic Monitoring Laboratory

    SciTech Connect

    McIsaac, C.V.; Sill, C.W.; Gehrke, R.J.; Killian, E.W.; Watts, K.D.; Amaro, C.R.

    1993-12-01

    A field test of the Rapid Transuranic Monitoring Laboratory (RTML) developed at the Idaho National Engineering Laboratory (INEL) was conducted as part of a demonstration sponsored by the Buried Waste Integrated Demonstration (BWID). The RTML is a mobile, field- deployable laboratory developed for use at buried radioactive waste remediation sites to allow onsite preparation and analysis of soil, smear, and air filter samples for alpha and gamma-emitting contaminants. Analytical instruments installed in the RTML include an extended range, germanium photon analysis spectrometer with an automatic sample changer, two large-area ionization chamber alpha spectrometers, and four alpha continuous air monitors. The performance of the RTML was tested at the Test Reactor Area and Cold Test Pit near the Radioactive Waste Management Complex at the INEL. Objectives, experimental procedures, and an evaluation of the performance of the RTML are presented.

  15. An Education Program to Reduce Unnecessary Laboratory Tests by Residents.

    ERIC Educational Resources Information Center

    Dowling, Patrick T.; And Others

    1989-01-01

    A program at an inner-city community health center involving 20 family practice residents provided an educational intervention concerning the use of laboratory tests based on quality of care, not cost containment. During the program, the use of thyroid stimulating hormone test declined, while complete blood counts ordered did not. (MSE)

  16. Do Laboratory Tests Predict Everyday Memory? A Neuropsychological Study.

    ERIC Educational Resources Information Center

    Sunderland, Alan; And Others

    1983-01-01

    The relationship between memory performance in everyday life and performance on laboratory tests was investigated with normal-memory and previously severely head-injured subjects. Correlation of the two test types was found in normal-memory and long-term head-injured, but not with the recently-injured. Highest correlations were with prose recall…

  17. 33 CFR 209.340 - Laboratory investigations and materials testing.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... procedures applicable to the performance of investigations and tests at Corps of Engineers laboratory... applies to Corps of Engineers Divisions and Districts operating soils, concrete, water quality and... local units of government when the total estimated cost of each investigation or test project is...

  18. 33 CFR 209.340 - Laboratory investigations and materials testing.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... procedures applicable to the performance of investigations and tests at Corps of Engineers laboratory... applies to Corps of Engineers Divisions and Districts operating soils, concrete, water quality and... local units of government when the total estimated cost of each investigation or test project is...

  19. 42 CFR 493.1415 - Condition: Laboratories performing moderate complexity testing; clinical consultant.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... complexity testing; clinical consultant. 493.1415 Section 493.1415 Public Health CENTERS FOR MEDICARE... LABORATORY REQUIREMENTS Personnel for Nonwaived Testing Laboratories Performing Moderate Complexity Testing § 493.1415 Condition: Laboratories performing moderate complexity testing; clinical consultant....

  20. 42 CFR 493.1409 - Condition: Laboratories performing moderate complexity testing; technical consultant.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... complexity testing; technical consultant. 493.1409 Section 493.1409 Public Health CENTERS FOR MEDICARE... LABORATORY REQUIREMENTS Personnel for Nonwaived Testing Laboratories Performing Moderate Complexity Testing § 493.1409 Condition: Laboratories performing moderate complexity testing; technical consultant....

  1. 42 CFR 493.1409 - Condition: Laboratories performing moderate complexity testing; technical consultant.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... complexity testing; technical consultant. 493.1409 Section 493.1409 Public Health CENTERS FOR MEDICARE... LABORATORY REQUIREMENTS Personnel for Nonwaived Testing Laboratories Performing Moderate Complexity Testing § 493.1409 Condition: Laboratories performing moderate complexity testing; technical consultant....

  2. 42 CFR 493.1415 - Condition: Laboratories performing moderate complexity testing; clinical consultant.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... complexity testing; clinical consultant. 493.1415 Section 493.1415 Public Health CENTERS FOR MEDICARE... LABORATORY REQUIREMENTS Personnel for Nonwaived Testing Laboratories Performing Moderate Complexity Testing § 493.1415 Condition: Laboratories performing moderate complexity testing; clinical consultant....

  3. Prevalence of renal and hepatobiliary disease, laboratory abnormalities, and potentially toxic medication exposures among persons with COPD

    PubMed Central

    Mapel, Douglas W; Marton, Jenõ P

    2013-01-01

    Background The purpose of this study was to describe the prevalence of renal and hepatic disease, related laboratory abnormalities, and potentially hepatotoxic and nephrotoxic medication use in a population-based cohort of persons with chronic obstructive pulmonary disease (COPD). Methods This was a retrospective case-control cohort analysis of COPD patients enrolled in one regional health system for at least 12 months during a 36-month study period (n = 2284). Each COPD patient was matched by age and gender to up to three persons not diagnosed with COPD (n = 5959). Results The mean age for cases and controls was 70.3 years, and 52.5% were women. The COPD cohort had significantly higher prevalences (cases/100) of acute, chronic, and unspecified renal failure as compared with controls (1.40 versus 0.59, 2.89 versus 0.79, and 1.09 versus 0.44, respectively). Among the cases, 31.3% had at least one renal or urinary tract diagnosis during the study period, as compared with 21.1% of controls. COPD cases also had more gallbladder disease (2.76 versus 1.63) and pancreatic disease (1.40 versus 0.60), but not hepatic disease. COPD patients were more likely to have at least one serum creatinine level (5.1 versus 2.1) or liver aspartate aminotransferase level (4.5 versus 2.7) that was more than twice the upper limit of normal. COPD patients had prescription fills for an average of 17.6 potentially nephrotoxic and 27.4 hepatotoxic drugs during the study period, as compared with 13.6 and 19.9 for the controls (P value for all comparisons < 0.01). Conclusion COPD patients have a substantially increased prevalence of renal, gallbladder, and pancreatic diseases, as well as abnormal renal and hepatic laboratory values, but not diagnosed liver disease. COPD patients are also more likely to be prescribed medications with potentially toxic renal or hepatic side effects. PMID:23515180

  4. Use of computers in quality assurance of laboratory testing.

    PubMed

    Tan, I K; Jacob, E; Lim, S H

    1990-09-01

    Implementation of comprehensive internal quality control programmes and participation in external quality assessment schemes to monitor analytical performance of laboratory tests have been widely accepted as an essential and integral part of good laboratory practice. As these programmes involve a great deal of repetitive statistical calculations and graphic presentation of data on quality control materials, many laboratories and practically all organisers of inter-laboratory quality assessment schemes increasingly rely on computers to handle the burdensome processing of data and to provide timely feedback in a manner that is easily understood and readily interpreted by analytical staff. However, in spite of the best effort to ensure reliable analytical performance, spurious and misleading results can still occur as a result of non-analytical errors which are not readily detected by methods designed to monitor the quality of analytical process. The use of sophisticated computer system has enabled our laboratory to check for the existence of some of these errors. This paper describes the application of computers in a variety of internal and external quality assessment programmes and demonstrates the usefulness of retrieving patients' cumulative test results and at the same time performing delta or percentage difference checks on such data in the detection of non-analytical errors and unexpected variations in results. The role of the computer in minimising transcription errors, reducing turn-around time of testing and reporting, as well as improving the quality of laboratory reports is also mentioned.

  5. Deep Borehole Field Test Laboratory and Borehole Testing Strategy

    SciTech Connect

    Kuhlman, Kristopher L.; Brady, Patrick V.; MacKinnon, Robert J.; Heath, Jason E.; Herrick, Courtney G.; Jensen, Richard P.; Gardner, W. Payton; Sevougian, S. David; Bryan, Charles R.; Jang, Je-Hun; Stein, Emily R.; Bauer, Stephen J.; Daley, Tom; Freifeld, Barry M.; Birkholzer, Jens; Spane, Frank A.

    2016-09-19

    Deep Borehole Disposal (DBD) of high-level radioactive wastes has been considered an option for geological isolation for many years (Hess et al. 1957). Recent advances in drilling technology have decreased costs and increased reliability for large-diameter (i.e., ≥50 cm [19.7”]) boreholes to depths of several kilometers (Beswick 2008; Beswick et al. 2014). These advances have therefore also increased the feasibility of the DBD concept (Brady et al. 2009; Cornwall 2015), and the current field test design will demonstrate the DBD concept and these advances. The US Department of Energy (DOE) Strategy for the Management and Disposal of Used Nuclear Fuel and High-Level Radioactive Waste (DOE 2013) specifically recommended developing a research and development plan for DBD. DOE sought input or expression of interest from States, local communities, individuals, private groups, academia, or any other stakeholders willing to host a Deep Borehole Field Test (DBFT). The DBFT includes drilling two boreholes nominally 200m [656’] apart to approximately 5 km [16,400’] total depth, in a region where crystalline basement is expected to begin at less than 2 km depth [6,560’]. The characterization borehole (CB) is the smaller-diameter borehole (i.e., 21.6 cm [8.5”] diameter at total depth), and will be drilled first. The geologic, hydrogeologic, geochemical, geomechanical and thermal testing will take place in the CB. The field test borehole (FTB) is the larger-diameter borehole (i.e., 43.2 cm [17”] diameter at total depth). Surface handling and borehole emplacement of test package will be demonstrated using the FTB to evaluate engineering feasibility and safety of disposal operations (SNL 2016).

  6. Evaluation of a laboratory test model annular momentum control device

    NASA Technical Reports Server (NTRS)

    Groom, N. J.; Terray, D. E.

    1978-01-01

    A 4068 Nm Sec laboratory test model annular momentum control device (AMCD) was described and static and dynamic test results were presented. An AMCD is a spinning annular rim suspended by noncontacting magnetic bearings and powered by a noncontacting linear electromagnetic motor. Test results include spin motor torque characteristics and spin motor and magnetic bearing drag losses. Limitations of some of the design approaches taken was also discussed.

  7. Unnecessary repeated total cholesterol tests in biochemistry laboratory

    PubMed Central

    Demir, Suleyman; Zorbozan, Nergiz; Basak, Elif

    2016-01-01

    Introduction We aimed to determine the number of repeated cholesterol (RC) tests and the ratio of unnecessary-repeated cholesterol (URC) tests among patients admitted to Pamukkale University Hospital (Denizli, Turkey) and provide solutions to avoid URC testing. Materials and methods Total cholesterol (T-cholesterol) tests (N = 86,817) between June 2014 and May 2015 were evaluated. The tests performed more than once per patient were determined as RC test (N = 28,811). RC test with an interval shorter than 4 weeks were determined as URC test (N = 3968) according to the shortest retest interval stated in ACC/AHA blood cholesterol guideline. RC testing included internal medicine, surgery and paediatric outpatients and inpatients. Reference change value (RCV) of total cholesterol was calculated. Results The 33.1% of the T-cholesterol tests were RC tests (N = 28,811), 13.7% of them were URC tests (N = 3968). Our RCV value was 25%. The percentage change between consecutive tests was less than RCV in 86.1% (N = 3418) of URC tests. URC tests were performed more frequently in patients with desirable total cholesterol value (P < 0.001). Conclusion There is a significant part of repeated T-cholesterol tests requested in our hospital. URC test requests can be evaluated by laboratories and the obtained data should be shared with clinicians. Laboratories can calculate RCV for the tests they performed and report this value with the test result. To prevent from URC tests, a warning plug-in can be added to hospital information software in accordance with guidelines to prevent from URC test requests. PMID:26981021

  8. The age of competence: an update on the international laboratory accreditation scene for veterinary testing laboratories.

    PubMed

    Wiegers, Ann L

    2002-03-01

    Many changes have recently taken place in the world of laboratory accreditation. These changes include the increased use of voluntary standards in lieu of regulations, a move towards harmonization (equivalent results using voluntary standards) over standardization (using the same procedures or regulations), and an increased focus on competence, which includes the competence of laboratories to conduct testing, the competence of accreditation bodies to operate accreditation programs, the competence of bodies such as the National Cooperation for Laboratory Accreditation (NACLA) to recognize accreditation bodies as meeting the requirements of relevant standards, and the competence of organizations providing services to the accreditation process, such as the operation of proficiency testing programs. To describe these changes, a brief and general description of the International Laboratory Accreditation Cooperation accreditation scheme is provided, including an update on relevant decisions and activities in the United States and a description of the organization and activities of the newly formed NACLA. Following this discussion, with emphasis on veterinary testing, is an overview of several national and international organizations, including accreditation bodies, that promote harmonization, standardization, and analytical excellence. Also outlined are relevant activities of these organizations, an overview of some of the standards and guidelines they produce, and a description of how such organizations interact with each other and with laboratories seeking recognition for competence. Next is a brief discussion of recent developments and trends in laboratory accreditation, the impact of these developments, and the costs and benefits of accreditation to laboratories. Suggestions to veterinary laboratories for formulating strategy for keeping current with developments in accreditation and for determining quality goals are included.

  9. Five Proficiency Testing Programs for the Jcss Weight Calibration Laboratories

    NASA Astrophysics Data System (ADS)

    Ueki, Masaaki; Sun, Jianxin; Ueda, Kazunaga

    The Japan Calibration Service System (JCSS) organized in 1993 accredits the measurement capability of calibration laboratories and ensures the traceability to the national measurement standards. As an essential part of accreditation of the measurement capability of calibration laboratories for the weights, the International Accreditation Japan (IAJapan) of National Institute of Technology and Evaluation has been operating the JCSS proficiency testing programs with the technical support of the National Metrology Institute of Japan (NMIJ/AIST). Up to now, five proficiency testing programs have been carried out for the JCSS weight calibration laboratories in the range of 2 mg to 10 kg. The proficiency testing programs organized by the IAJapan were carried out in accordance with ISO/IEC Guide 43 (JIS Q 17043), and the NMIJ was responsible for the technical aspect as a reference laboratory. This paper describes the methods of the five proficiency testing programs during the period from 1997 to 2009, and outlines assessment of the measurement capability of the JCSS weight calibration laboratories.

  10. Reproduction of natural corrosion by accelerated laboratory testing methods

    SciTech Connect

    Luo, J.S.; Wronkiewicz, D.J.; Mazer, J.J.; Bates, J.K.

    1996-05-01

    Various laboratory corrosion tests have been developed to study the behavior of glass waste forms under conditions similar to those expected in an engineered repository. The data generated by laboratory experiments are useful for understanding corrosion mechanisms and for developing chemical models to predict the long-term behavior of glass. However, it is challenging to demonstrate that these test methods produce results that can be directly related to projecting the behavior of glass waste forms over time periods of thousands of years. One method to build confidence in the applicability of the test methods is to study the natural processes that have been taking place over very long periods in environments similar to those of the repository. In this paper, we discuss whether accelerated testing methods alter the fundamental mechanisms of glass corrosion by comparing the alteration patterns that occur in naturally altered glasses with those that occur in accelerated laboratory environments. This comparison is done by (1) describing the alteration of glasses reacted in nature over long periods of time and in accelerated laboratory environments and (2) establishing the reaction kinetics of naturally altered glass and laboratory reacted glass waste forms.

  11. Amelogenin test abnormalities revealed in Belarusian population during forensic DNA analysis.

    PubMed

    Borovko, Sergey; Shyla, Alena; Korban, Victorya; Borovko, Alexandra

    2015-03-01

    Study of gender markers is a part of routine forensic genetic examination of crime scene and reference samples, paternity testing and personal identification. Amelogenin locus as a gender marker is included in majority of forensic STR kits of different manufacturers. In current study we report 11 cases of amelogenin abnormalities identified in males of Belarusian origin: 9 cases of AMELY dropout and 2 cases of AMELX dropout. Cases were obtained from forensic casework (n=9) and paternity testing (n=2) groups. In 4 out of 9 AMELY-negative cases deletion of AMELY was associated with the loss of DYS458 marker. In addition, we identified 3 males with SRY-positive XX male syndrome. Deletion of the long arm of the Y-chromosome was detected in two XX males. Loss of the major part of the Y-chromosome was identified in the third XX male. The presence of two X-chromosomes in XX males was confirmed with the use of Mentype(®) Argus X-8 PCR Amplification Kit. AMELY null allele observed in 2 out of 9 cases with AMELY dropout can be caused by mutation in the primer-binding site of AMELY allele. Primer-binding site mutations of AMELX can result in AMELX dropout identified in 2 cases with amplification failure of AMELX. Our study represents the first report and molecular genetic investigation of amelogenin abnormalities in the Belarusian population.

  12. Laboratory testing of the Sonnenschein charger, Part number DTL 12040

    SciTech Connect

    Hardin, J.E.; Martin, M.E.

    1990-09-01

    This report describes the results of testing the Sonnenschein DTL 12040 battery charger in the Idaho National Engineering Laboratory (INEL) battery laboratory. The purpose of this testing was to evaluate the suitability of this charger for charging electric vehicle battery packs made up of Sonnenschein sealed lead acid batteries or possibly other similar batteries. This evaluation consists primarily of identifying the charge algorithm used and evaluating the resulting charge behavior. Other characteristics of the charger that could be significant are also noted. 5 figs., 2 tabs.

  13. Energy-efficiency testing activities of the Mobile Energy Laboratory

    SciTech Connect

    Parker, G.B.

    1991-01-01

    This report summarizes energy-efficiency testing activities during the first and second quarters of fiscal year 1990 applying the Mobile Energy Laboratory (MEL) testing capabilities. Four MELs, developed by the US Department of Energy (DOE) Federal Energy Management Program (FEMP), are administered by Pacific Northwest Laboratory (PNL) for energy testing and program support functions at federal facilities. The using agencies principally fund MEL applications, while DOE/FEMP funds program administration and capability enhancement activities. This report fulfills the requirements established in the MEL Use Plan (PNL-6861) for semiannual reporting on energy-efficiency testing activities using the MEL capabilities. The MEL Use Committee, formally established in 1989, developed the MEL Use Plan and meets semiannually to establish priorities for energy-efficient testing applications using the MEL capabilities.

  14. A comparative study of five laboratory tests for foeto-placental dysfunction in late pregnancy

    PubMed Central

    Watson, D.; Siddiqui, S. A.; Stafford, J. E. H.; Gibbard, S.; Hewitt, V.

    1973-01-01

    Five foeto-placental function tests were studied in parallel in normal and abnormal late pregnancies with a view to establishing which test or tests is most satisfactorily able to identify the mother whose foetus is in danger. A critical examination of the levels in blood serum of two enzymes, placental phosphatase isoenzyme and cystine aminopeptidase, the polypeptide hormone placental lactogen (chorionic somatomammotrophin), and the oestrogen oestriol-17β is described. A correlation was attempted beween clinical data and the results of the above laboratory analyses and also with the daily urine oestrogen output. The plasma and urine oestriol levels proved generally to be the more useful warning tests in late pregnancy, whilst the plasma cystine aminopeptidase was the least sensitive indicator of foeto-placental dysfunction. PMID:4349714

  15. Infection control in the pulmonary function test laboratory

    PubMed Central

    Rasam, Shweta Amol; Apte, Komalkirti Keshavkiran; Salvi, Sundeep Santosh

    2015-01-01

    Pulmonary function testing plays a crucial role in the diagnostic evaluation of patients with lung diseases. Cases of cross infection acquired from the pulmonary function laboratory, although rare, have been reported from various countries. It is therefore imperative to identify the risks and potential organisms implicated in cross infections in a pulmonary function test (PFT) laboratory and implement better and more effective infection control procedures, which will help in preventing cross infections. The infrastructure, the daily patient flow, and the prevalent disinfection techniques used in a PFT laboratory, all play a significant role in transmission of infections. Simple measures to tackle the cross infection potential in a PFT laboratory can help reduce this risk to a bare minimum. Use of specialized techniques and equipment can also be of much use in a set up that has a high turnover of patients. This review aims at creating awareness about the possible pathogens and situations commonly encountered in a PFT laboratory. We have attempted to suggest some relevant and useful infection control measures with regard to disinfection, sterilization, and patient planning and segregation to help minimize the risk of cross infections in a PFT laboratory. The review also highlights the lacuna in the current scenario of PFT laboratories in India and the need to develop newer and better methods of infection control, which will be more user-friendly and cost effective. Further studies to study the possible pathogens in a PFT laboratory and evaluate the prevalent infection control strategies will be needed to enable us to draw more precious conclusions, which can lead to more relevant, contextual recommendations for cross infections control in PFT lab in India. PMID:26180386

  16. Compendium of Test Results of Recent Single Event Effect Tests Conducted by the Jet Propulsion Laboratory

    NASA Technical Reports Server (NTRS)

    McClure, Steven S.; Allen, Gregory R.; Irom, Farokh; Scheick, Leif Z.; Adell, Philippe C.; Miyahira, Tetsuo F.

    2010-01-01

    This paper reports heavy ion and proton-induced single event effect (SEE) results from recent tests for a variety of microelectronic devices. The compendium covers devices tested over the last two years by the Jet Propulsion Laboratory.

  17. Test plan for demonstration of Rapid Transuranic Monitoring Laboratory

    SciTech Connect

    McIsaac, C.V.; Sill, C.W.; Gehrke, R.J.; Killian, E.W.; Watts, K.D.

    1993-06-01

    This plan describes tests to demonstrate the capability of the Rapid Transuranic Monitoring Laboratory (RTML) to monitor airborne alpha-emitting radionuclides and analyze soil, smear, and filter samples for alpha- and gamma-emitting radionuclides under field conditions. The RTML will be tested during June 1993 at a site adjacent to the Cold Test Pit at the Radioactive Waste Management Complex at the Idaho National Engineering Laboratory. Measurement systems installed in the RTML that will be demonstrated include two large-area ionization chamber alpha spectrometers, an x-ray/gamma-ray spectrometer, and four alpha continuous air monitors. Test objectives, requirements for data quality, experimental apparatus and procedures, and safety and logistics issues are described.

  18. Safety in the Chemical Laboratory: Tested Disposal Methods for Chemical Wastes from Academic Laboratories.

    ERIC Educational Resources Information Center

    Armour, M. A.; And Others

    1985-01-01

    Describes procedures for disposing of dichromate cleaning solution, picric acid, organic azides, oxalic acid, chemical spills, and hydroperoxides in ethers and alkenes. These methods have been tested under laboratory conditions and are specific for individual chemicals rather than for groups of chemicals. (JN)

  19. Results of Laboratory Testing of Advanced Power Strips

    SciTech Connect

    Earle, L.; Sparn, B.

    2012-08-01

    Presented at the ACEEE Summer Study on Energy Efficiency in Buildings on August 12-17, 2012, this presentation reports on laboratory tests of 20 currently available advanced power strip products, which reduce wasteful electricity use of miscellaneous electric loads in buildings.

  20. 76 FR 10500 - Nationally Recognized Testing Laboratories Fees

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-25

    ... Occupational Safety and Health Administration 29 CFR Part 1910 Nationally Recognized Testing Laboratories Fees... Occupational Safety and Health Administration (OSHA) is adjusting the approach it uses for calculating the fees... prepayment of these fees. This adjustment increases the fees; OSHA is phasing in the fee increase over...

  1. GATE AND VACUUM FLUSHING OF SEWER SEDIMENT: LABORATORY TESTING

    EPA Science Inventory

    The objective of this study was to test the performance of a traditional gate-flushing device and a newly-designed vacuum-flushing device in removing sediment from combined sewers and CSO storage tanks. A laboratory hydraulic flume was used to simulate a reach of sewer or storag...

  2. Testing a Constrained MPC Controller in a Process Control Laboratory

    ERIC Educational Resources Information Center

    Ricardez-Sandoval, Luis A.; Blankespoor, Wesley; Budman, Hector M.

    2010-01-01

    This paper describes an experiment performed by the fourth year chemical engineering students in the process control laboratory at the University of Waterloo. The objective of this experiment is to test the capabilities of a constrained Model Predictive Controller (MPC) to control the operation of a Double Pipe Heat Exchanger (DPHE) in real time.…

  3. Cancer, reproductive abnormalities, and diabetes in Micronesia: the effect of nuclear testing.

    PubMed

    Yamada, Seiji

    2004-09-01

    Many suggest that cancer and other diseases in Micronesia have been caused by nuclear testing in the Pacific. The 50-year commemoration of the March 1, 1954 Bravo thermonuclear test has rekindled interest in this area. This paper explores the documentation for, and the plausibility of, claims for disease causation by nuclear testing. Given the sheer volume of testing that the US conducted in the Pacific, it appears plausible that excess cancer would have occurred in areas of Micronesia other than the Marshall Islands. An excess of birth abnormalities in the Marshall Islands has been documented. While diabetes is not a radiogenic disease, and other cancers are generally less radiogenic than leukemia or thyroid cancer, the social and cultural effects of nuclear testing specifically, and the strategic uses to which Micronesia has been put generally, have had roles in the social production of disease. Integration into a globalized, cosmopolitan economy-with attendant phenomena such as the importation of tobacco, alcohol, foods of poor nutritional value, and new cultural morés-are also factors.

  4. Verification and validation of diagnostic laboratory tests in clinical virology.

    PubMed

    Rabenau, Holger F; Kessler, Harald H; Kortenbusch, Marhild; Steinhorst, Andreas; Raggam, Reinhard B; Berger, Annemarie

    2007-10-01

    This review summarizes major issues of verification and validation procedures and describes minimum requirements for verification and validation of diagnostic assays in clinical virology including instructions for CE/IVD-labeled as well as for self-developed ("home-brewed") tests or test systems. It covers techniques useful for detection of virus specific antibodies, for detection of viral antigens, for detection of viral nucleic acids, and for isolation of viruses on cell cultures in the routine virology laboratory.

  5. Performance testing of radiobioassay laboratories: In vivo measurements, Final Report

    SciTech Connect

    MacLellan, J.A.; Traub, R.J.; Olsen, P.C.

    1990-04-01

    A study of two rounds of in vivo laboratory performance testing was undertaken by Pacific Northwest Laboratory (PNL) to determine the appropriateness of the in vivo performance criteria of draft American National Standards Institute (ANSI) standard ANSI N13.3, Performance Criteria for Bioassay.'' The draft standard provides guidance to in vivo counting facilities regarding the sensitivity, precision, and accuracy of measurements for certain categories of commonly assayed radionuclides and critical regions of the body. This report concludes the testing program by presenting the results of the Round Two testing. Testing involved two types of measurements: chest counting for radionuclide detection in the lung, and whole body counting for detection of uniformly distributed material. Each type of measurement was further divided into radionuclide categories as defined in the draft standard. The appropriateness of the draft standard criteria by measuring a laboratory's ability to attain them were judged by the results of both round One and Round Two testing. The testing determined that performance criteria are set at attainable levels, and the majority of in vivo monitoring facilities passed the criteria when complete results were submitted. 18 refs., 18 figs., 15 tabs.

  6. Diagnostic testing for Clostridium difficile in Italian microbiological laboratories.

    PubMed

    Spigaglia, Patrizia; Barbanti, Fabrizio; Morandi, Matteo; Moro, Maria Luisa; Mastrantonio, Paola

    2016-02-01

    A laboratory diagnosis survey of Clostridium difficile infection (CDI) was performed in Italy in 2012-2013. Questionnaires from 278 healthcare settings from 15 regions of Italy were collected and analysed. Eighty seven percent of the laboratories declared to routinely perform CDI diagnosis, 99% of them only after the clinician's request. Among the 216 laboratories providing information on the size of the hospitals in which they were located, 65 had more than 500 beds (large hospitals), while 151 had less than 500 beds (small hospitals). The average percentage of positive tests for C. difficile toxins was 12.2%. Almost half of the laboratories (42%) used immunoenzymatic assay (EIA) for Tox A/B as a stand-alone method, while only 34% used an algorithm for CDI as indicated by the European guidelines. A low percentage of laboratories performed molecular assays or C. difficile culture, 25% and 29%, respectively. Most laboratories (161/278) declared to type C. difficile strains, the majority in collaboration with a reference laboratory. Among the 103 C. difficile clinical isolates collected during the study, 31 different PCR-ribotypes were identified. PCR-ribotype 356/607 (27%) was predominant, followed by 018 (12%). These two PCR-ribotypes show 87.5% of similarity in ribotyping profile. PCR-ribotypes 027 and 078 represented 8% and 4% of the strains, respectively. Four PCR-ribotypes (027, 033, 078 and 126) were positive for the binary toxin CDT. In particular, PCR-ribotype 033 produces only CDT, and it has recently been associated with symptomatic cases. The majority of strains were multidrug resistant. In particular, all strains PCR-ribotypes 356/607 and 018 were resistant to moxifloxacin, rifampicin, erythromycin and clindamycin. The results obtained highlight the need to raise awareness to the microbiological diagnosis of CDI among clinicians and to implement and harmonize diagnostic methods for CDI in Italian laboratories in the perspective of a future national

  7. Containment testing for occupied and unoccupied laboratory chemical hoods

    SciTech Connect

    Greenley, P.L.; DiBerardinis, L.J.; Lorch, F.A.

    1999-07-01

    Containment of hazards in a laboratory chemical hood is based on the principle that air drawn through the face area of the hood is sufficient to overcome the many challenges at or near the opening. Challenges to overcome include, but are not limited to, air velocities near the hood, movement of the researcher, people walking past the hood, location of equipment inside the hood, size of the sash opening, and the shape and configuration of entrance conditions. To overcome these challenges, a sufficient face velocity must be maintained. Determining that proper face velocity must be maintained. Determining that proper face velocity for a given hood should be resolved by the system designer, facility safety officer, and researcher with these and other issues in mind. This research tests for containment at 100 feet per minute (fpm) face velocity on occupied hoods and tests the same hoods for containment at the reduced velocity of 60 fpm when unoccupied. Three laboratory chemical hoods of different sizes with several ash positions are used. The test results show that under ideal conditions in a test laboratory, an unoccupied hood (without a manikin) at 60 fpm contains as good as, if not better than, an occupied hood (with a manikin) at 100 fpm, as measured by the tracer gas tests specified in ANSI/ASHRAE 110-1995, Method of Testing Performance of Laboratory Fume Hoods (ASHRAE 1995). Further testing is needed to determine if this relationship is the same under conditions of actual use, i.e., cluttered hoods and presence of cross-drafts.

  8. The transportable heavy-duty engine emissions testing laboratory

    SciTech Connect

    Not Available

    1991-05-01

    West Virginia University has designed and constructed a Transportable Emissions Testing Laboratory for measuring emissions from heavy duty vehicles, such as buses and trucks operating on conventional and alternative fuels. The laboratory facility can be transported to a test site located at, or nearby, the home base of the vehicles to be tested. The laboratory has the capability of measuring vehicle emissions as the vehicle is operated under either transient or steady state loads and speeds. The exhaust emissions from the vehicle is sampled and the levels of the constituents of the emission are measured. The laboratory consists of two major units; a power absorber unit and an emissions measurement unit. A power absorber unit allows for the connection of a dynamic load to the drive train of the vehicle so that the vehicle can be driven'' through a test cycle while actually mounted on a stationary test bed. The emissions unit contains instrumentation and equipment which allows for the dilution of the vehicle's exhaust with air. The diluteed exhaust is sampled and analyzed to measure the level of concentration of those constituents which have been identified to have impact on the clean environment. Sampling probes withdraw diluted exhaust which is supplied to a number of different exhaust gas analysis instruments. The exhaust gas analysis instruments have the capability to measure the levels of the following exhaust gas constituents: carbon monoxide (CO), carbon dioxide (CO{sub 2}), oxides of nitrogen (NO{sub x}), unburned hydrocarbons (HC), formaldehyde (HCHO), methane and particulate matter. Additional instruments or sampling devices can be installed whenever measurements of additional constituents are desired. A computer based, data acquisition system is used to continuously monitor a wide range of parameters important to the operation of the test and to record the test results.

  9. NASA Glenn's Acoustical Testing Laboratory Awarded Accreditation by the National Voluntary Laboratory Accreditation Program

    NASA Technical Reports Server (NTRS)

    Akers, James C.; Cooper, Beth A.

    2004-01-01

    NASA Glenn Research Center's Acoustical Testing Laboratory (ATL) provides a comprehensive array of acoustical testing services, including sound pressure level, sound intensity level, and sound-power-level testing per International Standards Organization (ISO)1 3744. Since its establishment in September 2000, the ATL has provided acoustic emission testing and noise control services for a variety of customers, particularly microgravity space flight hardware that must meet International Space Station acoustic emission requirements. The ATL consists of a 23- by 27- by 20-ft (height) convertible hemi/anechoic test chamber and a separate sound-attenuating test support enclosure. The ATL employs a personal-computer-based data acquisition system that provides up to 26 channels of simultaneous data acquisition with real-time analysis (ref. 4). Specialized diagnostic tools, including a scanning sound-intensity system, allow the ATL's technical staff to support its clients' aggressive low-noise design efforts to meet the space station's acoustic emission requirement. From its inception, the ATL has pursued the goal of developing a comprehensive ISO 17025-compliant quality program that would incorporate Glenn's existing ISO 9000 quality system policies as well as ATL-specific technical policies and procedures. In March 2003, the ATL quality program was awarded accreditation by the National Voluntary Laboratory Accreditation Program (NVLAP) for sound-power-level testing in accordance with ISO 3744. The NVLAP program is administered by the National Institutes of Standards and Technology (NIST) of the U.S. Department of Commerce and provides third-party accreditation for testing and calibration laboratories. There are currently 24 NVLAP-accredited acoustical testing laboratories in the United States. NVLAP accreditation covering one or more specific testing procedures conducted in accordance with established test standards is awarded upon successful completion of an intensive

  10. Intervention to Improve Follow-up for Abnormal Papanicolaou Tests: A Randomized Clinical Trial

    PubMed Central

    Breitkopf, Carmen Radecki; Dawson, Lauren; Grady, James J.; Breitkopf, Daniel M.; Nelson-Becker, Carolyn; Snyder, Russell R.

    2014-01-01

    Objective To evaluate the effect of a theory-based, culturally-targeted intervention on adherence to follow-up among low-income and minority women who experience an abnormal Pap test. Methods 5,049 women were enrolled and underwent Pap testing. Of these, 378 had an abnormal result and 341 (90%) were randomized to 1 of 3 groups to receive their results: Intervention (I): culturally-targeted behavioral and normative beliefs + knowledge/skills + salience + environmental constraints/barriers counseling; Active Control (AC): non-targeted behavioral and normative beliefs + knowledge/skills + salience + environmental constraints/barriers counseling; or Standard Care Only (SCO). The primary outcome was attendance at the initial follow-up appointment. Secondary outcomes included delay in care, completion of care at 18 months, state anxiety (STAI Y-6), depressive symptoms (CES-D), and distress (CDDQ). Anxiety was assessed at enrollment, notification of results, and 7–14 days later with the CDDQ and CES-D. Results 299 women were included in intent-to-treat analyses. Adherence rates were 60% (I), 54% (AC), and 58% (SCO), p=0.73. Completion rates were 39% (I) and 35% in the AC and SCO groups, p=0.77. Delay in care (in days) was (M ±SD): 58 ±75 (I), 69 ±72 (AC), and 54 ±75 (SCO), p=0.75. Adherence was associated with higher anxiety at notification, p<0.01 while delay <90 days (vs. 90+) was associated with greater perceived personal responsibility, p<0.05. Women not completing their care (vs. those who did) had higher CES-D scores at enrollment, p<0.05. Conclusions A theory-based, culturally-targeted message was not more effective than a non-targeted message or standard care in improving behavior. PMID:23730719

  11. Identifying the Clinical Laboratory Tests from Unspecified "Other Lab Test" Data for Secondary Use.

    PubMed

    Pan, Xuequn; Cimino, James J

    2015-01-01

    Clinical laboratory results are stored in electronic health records (EHRs) as structured data coded with local or standard terms. However, laboratory tests that are performed at outside laboratories are often simply labeled "outside test" or something similar, with the actual test name in a free-text result or comment field. After being aggregated into clinical data repositories, these ambiguous labels impede the retrieval of specific test results. We present a general multi-step solution that can facilitate the identification, standardization, reconciliation, and transformation of such test results. We applied our approach to data in the NIH Biomedical Translational Research Information System (BTRIS) to identify laboratory tests, map comment values to the LOINC codes that will be incorporated into our Research Entities Dictionary (RED), and develop a reference table that can be used in the EHR data extract-transform-load (ETL) process.

  12. Thermocouple Calibration and Accuracy in a Materials Testing Laboratory

    NASA Technical Reports Server (NTRS)

    Lerch, B. A.; Nathal, M. V.; Keller, D. J.

    2002-01-01

    A consolidation of information has been provided that can be used to define procedures for enhancing and maintaining accuracy in temperature measurements in materials testing laboratories. These studies were restricted to type R and K thermocouples (TCs) tested in air. Thermocouple accuracies, as influenced by calibration methods, thermocouple stability, and manufacturer's tolerances were all quantified in terms of statistical confidence intervals. By calibrating specific TCs the benefits in accuracy can be as great as 6 C or 5X better compared to relying on manufacturer's tolerances. The results emphasize strict reliance on the defined testing protocol and on the need to establish recalibration frequencies in order to maintain these levels of accuracy.

  13. Testing hygrometers used in cytogenetics laboratories for metaphase preparation.

    PubMed

    Hartley, Thomas; Dun, Karen

    2011-07-01

    This protocol describes procedures for checking small laboratory hygrometers for accuracy at three relative humidity (rh) levels. The work arose out of the need to provide laboratory assessors with documentary evidence that the hygrometer used to monitor humidity in the vicinity of the laboratory where medical cytogenetics testing slides are prepared and dried in the ambient environment is reproducible and sufficiently accurate. The procedure is based upon the physicochemical principle that when water or certain saturated salt solutions are placed into a sealed environment, the humidity will equilibrate to well defined levels. We choose to check our hygrometers at three points: 95%, 75%, and 33% rh, using distilled water, saturated sodium chloride solution, and saturated magnesium chloride solution, respectively. Our results have demonstrated that the procedure is convenient and of sufficient accuracy to be fit for this annual hygrometer validation purpose. The procedure takes 24 hr per relative humidity point checked.

  14. Laboratory test method for dirt pickup resistance and stain removal

    NASA Astrophysics Data System (ADS)

    Ren, Shiwei; Zheng, Xueying; Liu, Yi; Jiang, Quan

    2017-03-01

    The pollution characteristics of current atmospheric particulates was summarized in the present investigation. The composition and proportion of the pollution sources used for dirt pickup resistance and stain removal test were adjusted, and the pollution sources used for new type dirt pickup resistance and stain removal test produced. In addition, a new dirt pickup method was adopted, and a set of new type laboratory dirt pickup resistance and stain removal tests developed by taking comprehensive consideration of the existing state and dirt pickup mode of actual atmospheric particulates. It verifies the rationality, feasibility and effectiveness of new test methods for dirt pickup resistance and stain removal based on the contrast test over the new and old test methods.

  15. Laboratory testing of West Valley reference 6 glass

    SciTech Connect

    Ebert, W.L.

    1995-07-01

    A series of laboratory tests is being conducted to characterize the corrosion of West Valley reference 6 glass (WV6) and to provide parametric values for modeling its long-term durability. Models require measurement of the corrosion rate in the absence of corrosion products and in fluids that are {open_quotes}saturated{close_quotes} with corrosion products, and the identification of alteration phases. Corrosion rates in dilute and saturated conditions were measured using MCC-1 and PCT tests, respectively. Vapor hydration tests were performed to generate secondary phases. The PCT tests show the WV6 glass to be more durable than SRL EA, SRL 202, and HW-39-1 glasses. Vapor hydration tests show weeksite (a uranyl silicate), a potassium-bearing zeolite, analcime, potassium feldspar, a calcium silicate phase, and lithium phosphate to form as WV6 glass corrodes. Test results are presented and their relevance to long-term performance discussed.

  16. CLINICAL PRACTICES FOR INTERMEDIATE/EQUIVICAL SWEAT TESTS FOLLOWING ABNORMAL CYSTIC FIBROSIS NEWBORN SCREENS

    PubMed Central

    Nelson, Megan R.; Adamski, Craig R.; Tluczek, Audrey

    2013-01-01

    Background Newborn screening (NBS) for cystic fibrosis (CF) has become standard practice in many countries. Consequently, the prevalence of infants with intermediate/equivalent sweat test results has increased. This study examined clinical practices in the United States (US) related to intermediate sweat test results subsequent to NBS. Methods Telephone surveys were conducted with staff from 77 (47% response rate) US CF centers documenting clinical practices related to intermediate/equivalent sweat chloride levels (30–59 mmol/L) following abnormal NBS. Results Thirty percent of centers followed CF Foundation guidelines for classifying intermediate/equivalent results. There was much variability in sweat testing procedures, diagnostic labels, additional diagnostics, addressing prognosis, and services offered to parents. CF center staff identified a need for resources to better address the uncertainty associated with intermediate/equivalent results. Conclusion Findings warrant evaluation of barriers to adherence with existing guidelines and establishment of internationally accepted, evidenced-based, clinical standards for infants with intermediate/equivalent CF NBS results. PMID:21855423

  17. [Symptom based approaches in point of care laboratory testing].

    PubMed

    Risch, Lorenz; Senn, Oliver

    2015-02-01

    Point of care testing (POCT) allows, among others, for efficient care of patients presenting with acute problems to primary care physicians. A combination of clinical information and laboratory results enables physicians to obtain posttest probabilities for the presence or absence of a specific disease. In order to rule in or rule out a disease, the physician has to know both the pretest probability for a disease in a patient as well as the analytical and diagnostic characteristics of the employed test. Pretest probability can be assessed by scores or by personal judgment of the experienced clinician. This article presents the basics of the Bayes theorem together with its clinical applications in acute scenarios in primary health care. These scenarios comprise the use of D-Dimer testing in ruling out venous thromboembolism, rapid testing of group A streptococci in the setting of acute pharyngitis, troponin testing in patients with thoracic pain, c-reactive protein (CRP) testing in patients presenting with acute cough and fever, as well as urine dipstick testing in suspected urinary tract infection. These examples illustrate, that risk stratification before conducting laboratory analysis is of utmost importance in order to obtain valid results for ruling in or ruling out diseases in POCT-settings.

  18. Laboratory or Field Tests for Evaluating Firefighters' Work Capacity?

    PubMed Central

    Lindberg, Ann-Sofie; Oksa, Juha; Malm, Christer

    2014-01-01

    Muscle strength is important for firefighters work capacity. Laboratory tests used for measurements of muscle strength, however, are complicated, expensive and time consuming. The aims of the present study were to investigate correlations between physical capacity within commonly occurring and physically demanding firefighting work tasks and both laboratory and field tests in full time (N = 8) and part-time (N = 10) male firefighters and civilian men (N = 8) and women (N = 12), and also to give recommendations as to which field tests might be useful for evaluating firefighters' physical work capacity. Laboratory tests of isokinetic maximal (IM) and endurance (IE) muscle power and dynamic balance, field tests including maximal and endurance muscle performance, and simulated firefighting work tasks were performed. Correlations with work capacity were analyzed with Spearman's rank correlation coefficient (rs). The highest significant (p<0.01) correlations with laboratory and field tests were for Cutting: IE trunk extension (rs = 0.72) and maximal hand grip strength (rs = 0.67), for Stairs: IE shoulder flexion (rs = −0.81) and barbell shoulder press (rs = −0.77), for Pulling: IE shoulder extension (rs = −0.82) and bench press (rs = −0.85), for Demolition: IE knee extension (rs = 0.75) and bench press (rs = 0.83), for Rescue: IE shoulder flexion (rs = −0.83) and bench press (rs = −0.82), and for the Terrain work task: IE trunk flexion (rs = −0.58) and upright barbell row (rs = −0.70). In conclusion, field tests may be used instead of laboratory tests. Maximal hand grip strength, bench press, chin ups, dips, upright barbell row, standing broad jump, and barbell shoulder press were strongly correlated (rs≥0.7) with work capacity and are therefore recommended for evaluating firefighters work capacity. PMID:24614596

  19. Laboratory diagnosis and interpretation of tests for syphilis.

    PubMed Central

    Larsen, S A; Steiner, B M; Rudolph, A H

    1995-01-01

    The lack of a method for demonstrating the presence of Treponema pallidum by growth necessitates the use of alternative methods. Traditionally, these methods are divided into direct detection methods (animal inoculation, dark-field microscopy, etc.) and serologic tests for the presence of patient antibody against T. pallidum. Serologic methods are further divided into two classes. One class, the nontreponemal tests, detects antibodies to lipoidal antigens present in either the host or T. pallidum; examples are the Venereal Disease Research Laboratory and rapid plasma reagin and tests. Reactivity in these tests generally indicates host tissue damage that may not be specific for syphilis. Because these tests are easy and inexpensive to perform, they are commonly used for screening, and with proper clinical signs they are suggestive of syphilis. The other class of test, the treponemal tests, uses specific treponemal antigens. Confirmation of infection requires a reactive treponemal test. Examples of the treponemal tests are the microhemagglutination assay for antibodies to T. pallidum and the fluorescent treponemal antibody absorption test. These tests are more expensive and complicated to perform than the nontreponemal tests. On the horizon are a number of direct antigen, enzyme-linked immunosorbent assay, and PCR techniques. Several of these techniques have shown promise in clinical trials for the diagnosis of congenital syphilis and neurosyphilis that are presently difficult to diagnose. PMID:7704889

  20. Radioactive material package testing capabilities at Sandia National Laboratories

    SciTech Connect

    Uncapher, W.L.; Hohnstreiter, G.F.

    1995-12-31

    Evaluation and certification of radioactive and hazardous material transport packages can be accomplished by subjecting these packages to normal transport and hypothetical accident test conditions. The regulations allow package designers to certify packages using analysis, testing, or a combination of analysis and testing. Testing can be used to substantiate assumptions used in analytical models and to demonstrate package structural and thermal response. Regulatory test conditions include impact, puncture, crush, penetration, water spray, immersion, and thermal environments. Testing facilities are used to simulate the required test conditions and provide measurement response data. Over the past four decades, comprehensive testing facilities have been developed at Sandia National Laboratories to perform a broad range of verification and certification tests on hazardous and radioactive material packages or component sections. Sandia`s facilities provide an experience base that has been established during the development and certification of many package designs. These unique facilities, along with innovative instrumentation data collection capabilities and techniques, simulate a broad range of testing environments. In certain package designs, package testing can be an economical alternative to complex analysis to resolve regulatory questions or concerns.

  1. TEST PLAN FOR MONITORING COOLING COILS IN A LABORATORY SETTING

    SciTech Connect

    Don B. Shirey, III

    2002-04-01

    The objective of this research project is to understand and quantify the moisture removal performance of cooling coils at part-load conditions. The project will include a comprehensive literature review, detailed measurement of cooling coil performance in a laboratory facility, monitoring cooling systems at several field test sites, and development/validation of engineering models that can be used in energy calculations and building simulations. This document contains the detailed test plan for monitoring cooling coil performance in a laboratory setting. Detailed measurements will be taken on up to 10 direct expansion (DX) and chilled water cooling coils in various configurations to understand the impact of coil geometry and operating conditions on transient moisture condensation and evaporation.

  2. Weld Tests Conducted by the Idaho National Laboratory

    SciTech Connect

    Larry Zirker; Lance Lauerhass; James Dowalo

    2007-02-01

    During the fiscal year of 2006, the Idaho National Laboratory (INL) performed many tests and work relating to the Mobile Melt-Dilute (MMD) Project components. Tests performed on the Staubli quick disconnect fittings showed promising results, but more tests were needed validate the fittings. Changes were made to the shield plug design—reduced the closure groove weld depth between the top of the canister and the top plate of the shielding plug from 0.5-in to 0.375-in deep. Other changes include a cap to cover the fitting, lifting pintle and welding code citations on the prints. Tests conducted showed stainless steel tubing, with 0.25-in, 0.375-in, and 0.5-in diameters, all with 0.035-in wall thickness, could be pinch seal welded using commercially available resistance welding equipment. Subsequent testing showed that these welds could be real-time inspected with ultrasonic inspection methods.

  3. Laboratory Diagnostics Market in East Africa: A Survey of Test Types, Test Availability, and Test Prices in Kampala, Uganda

    PubMed Central

    Schroeder, Lee F.; Elbireer, Ali; Jackson, J. Brooks; Amukele, Timothy K.

    2015-01-01

    Background Diagnostic laboratory tests are routinely defined in terms of their sensitivity, specificity, and ease of use. But the actual clinical impact of a diagnostic test also depends on its availability and price. This is especially true in resource-limited settings such as sub-Saharan Africa. We present a first-of-its-kind report of diagnostic test types, availability, and prices in Kampala, Uganda. Methods Test types (identity) and availability were based on menus and volumes obtained from clinical laboratories in late 2011 in Kampala using a standard questionnaire. As a measure of test availability, we used the Availability Index (AI). AI is the combined daily testing volumes of laboratories offering a given test, divided by the combined daily testing volumes of all laboratories in Kampala. Test prices were based on a sampling of prices collected in person and via telephone surveys in 2015. Findings Test volumes and menus were obtained for 95% (907/954) of laboratories in Kampala city. These 907 laboratories offered 100 different test types. The ten most commonly offered tests in decreasing order were Malaria, HCG, HIV serology, Syphilis, Typhoid, Urinalysis, Brucellosis, Stool Analysis, Glucose, and ABO/Rh. In terms of AI, the 100 tests clustered into three groups: high (12 tests), moderate (33 tests), and minimal (55 tests) availability. 50% and 36% of overall availability was provided through private and public laboratories, respectively. Point-of-care laboratories contributed 35% to the AI of high availability tests, but only 6% to the AI of the other tests. The mean price of the most commonly offered test types was $2.62 (range $1.83–$3.46). Interpretation One hundred different laboratory test types were in use in Kampala in late 2011. Both public and private laboratories were critical to test availability. The tests offered in point-of-care laboratories tended to be the most available tests. Prices of the most common tests ranged from $1

  4. Proposals for ORNL (Oak Ridge National Laboratory) support to Tiber LLNL (Lawrence Livermore National Laboratory). [Engineering Test Reactor

    SciTech Connect

    Berry, L.A.; Rosenthal, M.W.; Saltmarsh, M.J.; Shannon, T.E.; Sheffield, J.

    1987-01-27

    This document describes the interests and capabilities of Oak Ridge National Laboratory in their proposals to support the Lawrence Livermore National Laboratory (LLNL) Engineering Test Reactor (ETR) project. Five individual proposals are cataloged separately. (FI)

  5. Federal laboratory nondestructive testing research and development applicable to industry

    SciTech Connect

    Smith, S.A.; Moore, N.L.

    1987-02-01

    This document presents the results of a survey of nondestructive testing (NDT) and related sensor technology research and development (R and D) at selected federal laboratories. Objective was to identify and characterize NDT activities that could be applied to improving energy efficiency and overall productivity in US manufacturing. Numerous federally supported R and D programs were identified in areas such as acoustic emissions, eddy current, radiography, computer tomography and ultrasonics. A Preliminary Findings Report was sent to industry representatives, which generated considerable interest.

  6. Prediction of sprint triathlon performance from laboratory tests.

    PubMed

    Van Schuylenbergh, R; Eynde, B Vanden; Hespel, P

    2004-01-01

    This study investigated whether sprint triathlon performance can be adequately predicted from laboratory tests. Ten triathletes [mean (SEM), age 21.8 (0.3) years, height 179 (2) cm, body mass 67.5 (2.5) kg] performed two graded maximal exercise test in random order, either on their own bicycle which was mounted on an ergometer or on a treadmill, to determine their peak oxygen consumption ( VO(2)peak). Furthermore, they participated in two to three 30-min constant-load tests in both swimming, cycling and running to establish their maximal lactate steady state (MLSS) in each exercise mode. Swim tests were performed in a 25-m swimming pool (water temperature 27 degrees C). During each test heart rate (HR), power output (PO) or running/swimming speed and blood lactate concentration (BLC) were recorded at regular intervals. Oxygen uptake ( VO(2)) was continuously measured during the graded tests. Two weeks after the laboratory tests all subjects competed in a triathlon race (500 m swim, 20-km bike, 5-km run) [1 h 4 min 45 s (1 min 38 s)]. Peak HR was 7 beats.min(-1) lower in the graded cycle test than in the treadmill test ( p<0.05) at similar peak BLC (approximately 10 mmol.l(-1)) and VO(2)peak (approximately 5 L.min(-1)). High correlations were found between VO(2)peak during cycling ( r=-0.71, p<0.05) or running ( r=-0.69, p<0.05) and triathlon performance. Stepwise multiple regression analysis showed that running speed and swimming speed at MLSS, together with BLC in running at MLSS, yielded the best prediction of performance [1 h 5 min 18 s (1 min 49 s)]. Thus, our data indicate that exercise tests aimed to determine MLSS in running and swimming allow for a precise estimation of sprint triathlon performance.

  7. The Lincoln Laboratory-Aerospace Medical Research Laboratory digital speech test facility

    NASA Astrophysics Data System (ADS)

    Tierney, J.; Schecter, H.

    1984-05-01

    A narrowband digital speech communication test facility has been established and operates between Lincoln Laboratory and the Wright-Patterson Aerospace Medical Research Laboratory. Noise fields simulating the acoustic environments of E3A and F-15 aircraft are established and Air Force personnel use the link operating at 2400 bps with a vocoder designed at Lincoln Laboratory, and a commercial telephone line modem. The facility includes a digital signal processing computer which can introduce bit errors and delay into the transmit and receive data. Communication scenarios are used to exercise the vocoder-modem channel with the dynamics and vocabulary of typical operational exchanges. Answers to a standard questionnaire provide acceptability data for the 2400 bps JTIDS class 2 voice channel. For the tests run so far, the 2400 bps voice is acceptable in the sense of positive user response to the questionnaire. Further testing using error and delay simulations will follow. An F-15 to F-15 link will be simulated at AMRL using a pair of vocoders operating back-to-back and in separate noise chambers.

  8. Hydrogen Field Test Standard: Laboratory and Field Performance

    PubMed Central

    Pope, Jodie G.; Wright, John D.

    2015-01-01

    The National Institute of Standards and Technology (NIST) developed a prototype field test standard (FTS) that incorporates three test methods that could be used by state weights and measures inspectors to periodically verify the accuracy of retail hydrogen dispensers, much as gasoline dispensers are tested today. The three field test methods are: 1) gravimetric, 2) Pressure, Volume, Temperature (PVT), and 3) master meter. The FTS was tested in NIST's Transient Flow Facility with helium gas and in the field at a hydrogen dispenser location. All three methods agree within 0.57 % and 1.53 % for all test drafts of helium gas in the laboratory setting and of hydrogen gas in the field, respectively. The time required to perform six test drafts is similar for all three methods, ranging from 6 h for the gravimetric and master meter methods to 8 h for the PVT method. The laboratory tests show that 1) it is critical to wait for thermal equilibrium to achieve density measurements in the FTS that meet the desired uncertainty requirements for the PVT and master meter methods; in general, we found a wait time of 20 minutes introduces errors < 0.1 % and < 0.04 % in the PVT and master meter methods, respectively and 2) buoyancy corrections are important for the lowest uncertainty gravimetric measurements. The field tests show that sensor drift can become a largest component of uncertainty that is not present in the laboratory setting. The scale was calibrated after it was set up at the field location. Checks of the calibration throughout testing showed drift of 0.031 %. Calibration of the master meter and the pressure sensors prior to travel to the field location and upon return showed significant drifts in their calibrations; 0.14 % and up to 1.7 %, respectively. This highlights the need for better sensor selection and/or more robust sensor testing prior to putting into field service. All three test methods are capable of being successfully performed in the field and give

  9. Biometric identification devices -- Laboratory testing vs. real life

    SciTech Connect

    Ahrens, J.S.

    1997-05-01

    For over fifteen years Sandia National Laboratories has been involved in laboratory testing of biometric identification devices. The key concept of biometric identification devices is the ability for the system to identify some unique aspect of the individual rather than some object a person may be carrying or some password they are required to know. Tests were conducted to verify manufacturer`s performance claims, to determine strengths/weaknesses of devices, and to determine devices that meet the US Department of energy`s needs. However, during recent field installation, significantly different performance was observed than was predicted by laboratory tests. Although most people using the device believed it operated adequately, the performance observed was over an order of magnitude worse than predicted. The search for reasons behind this gap between the predicted and the actual performance has revealed many possible contributing factors. As engineers, the most valuable lesson to be learned from this experience is the value of scientists and engineers with (1) common sense, (2) knowledge of human behavior, (3) the ability to observe the real world, and (4) the capability to realize the significant differences between controlled experiments and actual installations.

  10. Dementia workup. Deciding on laboratory testing for the elderly.

    PubMed Central

    Frank, C.

    1998-01-01

    OBJECTIVE: To review Canadian Consensus Conference on the Assessment of Dementia (CCCAD) guidelines for laboratory evaluation of dementia, and to make recommendations to family physicians based on these guidelines and other literature. DATA SOURCES: English-language data sources from 1992 to March 1997 were searched on MEDLINE using the MeSH headings dementia, dementia/diagnosis, and cognition. Key words relating to specific laboratory tests or conditions, such as neurosyphilis or vitamin B12, were also used. STUDY SELECTION: Original research articles using prospective and retrospective methods were accepted. Articles reviewing the general investigation of potentially reversible dementia were included, as were articles looking at the sensitivity, specificity, and utility of investigations for specific conditions causing dementia. SYNTHESIS: Family physicians are not always aware of CCCAD recommendations for the investigation of dementia. There was C-level evidence for use of CCCAD core investigations (complete blood count and electrolyte, glucose, calcium, and thyroid levels) and for tests to be done "when the clinical situation warrants" (B12 levels, computed tomography scan of the head, and testing for syphilis). CONCLUSIONS: The CCCAD guidelines were supported by most literature on the workup of dementia. Prospective cohort studies suggest use of clinical judgment in ordering laboratory investigations. No controlled trials were available, and most recommendations arose from consensus rather than from research evidence. The prevalence of reversible dementias is likely lower than previously believed, which further supports a selective approach to investigations. Identification of reversible causes and exacerbating factors is still the goal. PMID:9678278

  11. 42 CFR 493.1481 - Condition: Laboratories performing high complexity testing; cytotechnologist.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... testing; cytotechnologist. 493.1481 Section 493.1481 Public Health CENTERS FOR MEDICARE & MEDICAID... REQUIREMENTS Personnel for Nonwaived Testing Laboratories Performing High Complexity Testing § 493.1481 Condition: Laboratories performing high complexity testing; cytotechnologist. For the subspecialty...

  12. 42 CFR 493.1481 - Condition: Laboratories performing high complexity testing; cytotechnologist.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... testing; cytotechnologist. 493.1481 Section 493.1481 Public Health CENTERS FOR MEDICARE & MEDICAID... REQUIREMENTS Personnel for Nonwaived Testing Laboratories Performing High Complexity Testing § 493.1481 Condition: Laboratories performing high complexity testing; cytotechnologist. For the subspecialty...

  13. TESTING OF THE RADBALL TECHNOLOGY AT SAVANNAH RIVER NATIONAL LABORATORY

    SciTech Connect

    Farfan, E.; Foley, T.

    2010-02-10

    The United Kingdom's National Nuclear Laboratory (NNL) has developed a remote, nonelectrical, radiation-mapping device known as RadBall (patent pending), which offers a means to locate and quantify radiation hazards and sources within contaminated areas of the nuclear industry. Positive results from initial deployment trials in nuclear waste reprocessing plants at Sellafield in the United Kingdom and the anticipated future potential use of RadBall throughout the U.S. Department of Energy Complex have led to the NNL partnering with the Savannah River National Laboratory (SRNL) to further test, underpin, and strengthen the technical performance of the technology. The study completed at SRNL addresses key aspects of the testing of the RadBall technology. The first set of tests was performed at Savannah River Nuclear Solutions Health Physics Instrument Calibration Laboratory (HPICL) using various gamma-ray sources and an x-ray machine with known radiological characteristics. The objective of these preliminary tests was to identify the optimal dose and collimator thickness. The second set of tests involved a highly contaminated hot cell. The objective of this testing was to characterize a hot cell with unknown radiation sources. The RadBall calibration experiments and hot cell deployment were successful in that for each trial radiation tracks were visible. The deployment of RadBall can be accomplished in different ways depending on the size and characteristics of the contaminated area (e.g., a hot cell that already has a crane/manipulator available or highly contaminated room that requires the use of a remote control device with sensor and video equipment to position RadBall). This report also presents SRNL-designed RadBall accessories for future RadBall deployment (a harness, PODS, and robot).

  14. Mars Science Laboratory Flight Software Boot Robustness Testing Project Report

    NASA Technical Reports Server (NTRS)

    Roth, Brian

    2011-01-01

    On the surface of Mars, the Mars Science Laboratory will boot up its flight computers every morning, having charged the batteries through the night. This boot process is complicated, critical, and affected by numerous hardware states that can be difficult to test. The hardware test beds do not facilitate testing a long duration of back-to-back unmanned automated tests, and although the software simulation has provided the necessary functionality and fidelity for this boot testing, there has not been support for the full flexibility necessary for this task. Therefore to perform this testing a framework has been build around the software simulation that supports running automated tests loading a variety of starting configurations for software and hardware states. This implementation has been tested against the nominal cases to validate the methodology, and support for configuring off-nominal cases is ongoing. The implication of this testing is that the introduction of input configurations that have yet proved difficult to test may reveal boot scenarios worth higher fidelity investigation, and in other cases increase confidence in the robustness of the flight software boot process.

  15. Mobile Energy Laboratory energy-efficiency testing programs

    NASA Astrophysics Data System (ADS)

    Parker, G. B.; Currie, J. W.

    1991-09-01

    This report summarizes energy-efficiency testing activities applying the Mobile Energy Laboratory (MEL) testing capabilities during the first and second quarters of fiscal year (FY) 1991. The MELs, developed by the U.S. Department of Energy (DOE) Federal Energy Management Program (FEMP), are administered by Pacific Northwest Laboratory (PNL) and the Naval Energy and Environmental Support Activity (NEESA) for energy testing and energy conservation program support functions at Federal facilities. The using agencies principally fund MEL applications, while DOE/FEMP funds program administration and capability enhancement activities. This report fulfills the requirements established in Section 8 of the MEL Use Plan (PNL-6861) for semiannual reporting on energy-efficiency testing activities using the MEL capabilities. The MEL Use Committee, formally established in 1989, developed the MEL Use Plan and meets semiannually to establish priorities for energy-efficient testing applications using the MEL capabilities. The MEL Use Committee is composed of one representative each of the U.S. Department of Energy, U.S. Army, U.S. Air Force, U.S. Navy, and other Federal agencies.

  16. Mobile Energy Laboratory energy-efficiency testing programs

    SciTech Connect

    Parker, G.B.; Currie, J.W.

    1991-09-01

    This report summarizes energy-efficiency testing activities applying the Mobile Energy Laboratory (MEL) testing capabilities during the first and second quarters of fiscal year (FY) 1991. The MELs, developed by the US Department of Energy (DOE) Federal Energy Management Program (FEMP), are administered by Pacific Northwest Laboratory (PNL) and the Naval Energy and Environmental Support Activity (NEESA) for energy testing and energy conservation program support functions at federal facilities. The using agencies principally fund MEL applications, while DOE/FEMP funds program administration and capability enhancement activities. This report fulfills the requirements established in Section 8 of the MEL Use Plan (PNL-6861) for semiannual reporting on energy-efficiency testing activities using the MEL capabilities. The MEL Use Committee, formally established in 1989, developed the MEL Use Plan and meets semiannually to establish priorities for energy-efficient testing applications using the MEL capabilities. The MEL Use Committee is composed of one representative each of the US Department of Energy, US Army, US Air Force, US Navy, and other federal agencies.

  17. Mobile Energy Laboratory energy-efficiency testing programs

    SciTech Connect

    Parker, G B; Currie, J W

    1992-03-01

    This report summarizes energy-efficiency testing activities applying the Mobile Energy Laboratory (MEL) testing capabilities during the third and fourth quarters of fiscal year (FY) 1991. The MELs, developed by the US Department of Energy (DOE) Federal Energy Management Program (FEMP), are administered by Pacific Northwest Laboratory (PNL) and the Naval Energy and Environmental Support Activity (NEESA) for energy testing and energy conservation program support functions at federal facilities. The using agencies principally fund MEL applications, while DOE/FEMP funds program administration and capability enhancement activities. This report fulfills the requirements established in Section 8 of the MEL Use Plan (PNL-6861) for semi-annual reporting on energy-efficiency testing activities using the MEL capabilities. The MEL Use Committee, formally established in 1989, developed the MEL Use Plan and meets semi-annually to establish priorities for energy-efficient testing applications using the MEL capabilities. The MEL Use Committee is composed of one representative each of the US Department of Energy, US Army, US Air Force, US Navy, and other federal agencies.

  18. Should patients with abnormal liver function tests in primary care be tested for chronic viral hepatitis: cost minimisation analysis based on a comprehensively tested cohort

    PubMed Central

    2011-01-01

    Background Liver function tests (LFTs) are ordered in large numbers in primary care, and the Birmingham and Lambeth Liver Evaluation Testing Strategies (BALLETS) study was set up to assess their usefulness in patients with no pre-existing or self-evident liver disease. All patients were tested for chronic viral hepatitis thereby providing an opportunity to compare various strategies for detection of this serious treatable disease. Methods This study uses data from the BALLETS cohort to compare various testing strategies for viral hepatitis in patients who had received an abnormal LFT result. The aim was to inform a strategy for identification of patients with chronic viral hepatitis. We used a cost-minimisation analysis to define a base case and then calculated the incremental cost per case detected to inform a strategy that could guide testing for chronic viral hepatitis. Results Of the 1,236 study patients with an abnormal LFT, 13 had chronic viral hepatitis (nine hepatitis B and four hepatitis C). The strategy advocated by the current guidelines (repeating the LFT with a view to testing for specific disease if it remained abnormal) was less efficient (more expensive per case detected) than a simple policy of testing all patients for viral hepatitis without repeating LFTs. A more selective strategy of viral testing all patients for viral hepatitis if they were born in countries where viral hepatitis was prevalent provided high efficiency with little loss of sensitivity. A notably high alanine aminotransferase (ALT) level (greater than twice the upper limit of normal) on the initial ALT test had high predictive value, but was insensitive, missing half the cases of viral infection. Conclusions Based on this analysis and on widely accepted clinical principles, a "fast and frugal" heuristic was produced to guide general practitioners with respect to diagnosing cases of viral hepatitis in asymptomatic patients with abnormal LFTs. It recommends testing all patients

  19. Abnormal pap tests among women living in a Hispanic migrant farmworker community: A narrative of health literacy.

    PubMed

    Vamos, Cheryl A; Lockhart, Elizabeth; Vázquez-Otero, Coralia; Thompson, Erika L; Proctor, Sara; Wells, Kristen J; Daley, Ellen M

    2016-08-19

    This study explored narrative responses following abnormal Pap tests among Hispanic migrant farmworkers (N = 18; ages 22-50 years) via in-depth interviews in Florida. Qualitative analyses utilized health literacy domains (obtain/process/understand/communicate) as a conceptual framework. Participants described how they (1) obtained information about getting a Pap test, (2) processed positive and negative reactions following results, (3) understood results and recommended health-promoting behaviors, and (4) communicated and received social support. Women had disparate reactions and understanding following an abnormal Pap result. Health literacy was a meaningful conceptual framework to understand assets and gaps among women receiving an abnormal Pap test result. Future interventions should incorporate health literacy domains and facilitate patient-provider communications and social support to assist women in decision-making and health-promoting behaviors, ultimately decreasing cancer disparities.

  20. A novel cause for abnormal liver function tests in pregnancy and the puerperium: non-alcoholic fatty liver disease.

    PubMed

    Page, L M; Girling, J C

    2011-11-01

    Non-alcoholic fatty liver disease (NAFLD) is the commonest liver disease in the western world, but has never been reported in pregnancy before. We suggest that NAFLD should also be considered as a cause for abnormal liver function tests during pregnancy. As NAFLD is driven by insulin resistance, it is biologically plausible that pregnancy may reveal previously subclinical disease. Obstetricians have a vital role in optimising maternal health during and after pregnancy and therefore we need to include NAFLD in the differential diagnosis for abnormal liver function tests and recommend lifestyle modifications that may prevent progression to cirrhosis and hepatocellular carcinoma.

  1. The Role of Laboratory Tests in Crohn’s Disease

    PubMed Central

    Cappello, Maria; Morreale, Gaetano Cristian

    2016-01-01

    In the past, laboratory tests were considered of limited value in Crohn’s disease (CD). In the era of biologics, laboratory tests have become essential to evaluate the inflammatory burden of the disease (C-reactive protein, fecal calprotectin) since symptoms-based scores are subjective, to predict the response to pharmacological options and the risk of relapse, to discriminate CD from ulcerative colitis, to select candidates to anti-tumor necrosis factors [screening tests looking for hepatitis B virus and hepatitis C virus status and latent tuberculosis], to assess the risk of adverse events (testing for thiopurine metabolites and thiopurine-methyltransferase activity), and to personalize and optimize therapy (therapeutic drug monitoring). Pharmacogenetics, though presently confined to the assessment of thiopurineme methyltransferase polymorphisms and hematological toxicity associated with thiopurine treatment, is a promising field that will contribute to a better understanding of the molecular mechanisms of the variability in response to the drugs used in CD with the attempt to expand personalized care and precision medicine strategies. PMID:27656094

  2. CERTS Microgrid Laboratory Test Bed - PIER Final Project Report

    SciTech Connect

    Eto, Joseph H.; Eto, Joseph H.; Lasseter, Robert; Schenkman, Ben; Klapp, Dave; Linton, Ed; Hurtado, Hector; Roy, Jean; Lewis, Nancy Jo; Stevens, John; Volkommer, Harry

    2008-07-25

    The objective of the CERTS Microgrid Laboratory Test Bed project was to enhance the ease of integrating small energy sources into a microgrid. The project accomplished this objective by developing and demonstrating three advanced techniques, collectively referred to as the CERTS Microgrid concept, that significantly reduce the level of custom field engineering needed to operate microgrids consisting of small generating sources. The techniques comprising the CERTS Microgrid concept are: 1) a method for effecting automatic and seamless transitions between grid-connected and islanded modes of operation; 2) an approach to electrical protection within the microgrid that does not depend on high fault currents; and 3) a method for microgrid control that achieves voltage and frequency stability under islanded conditions without requiring high-speed communications. The techniques were demonstrated at a full-scale test bed built near Columbus, Ohio and operated by American Electric Power. The testing fully confirmed earlier research that had been conducted initially through analytical simulations, then through laboratory emulations, and finally through factory acceptance testing of individual microgrid components. The islanding and resychronization method met all Institute of Electrical and Electronics Engineers 1547 and power quality requirements. The electrical protections system was able to distinguish between normal and faulted operation. The controls were found to be robust and under all conditions, including difficult motor starts. The results from these test are expected to lead to additional testing of enhancements to the basic techniques at the test bed to improve the business case for microgrid technologies, as well to field demonstrations involving microgrids that involve one or mroe of the CERTS Microgrid concepts.

  3. Are Guidelines Guiding us on How to Utilize Laboratory Tests?

    PubMed Central

    2015-01-01

    Increasing patient risks and costs associated with the delivery of health care services have been related to inappropriate and uncontrolled use of biomarkers which make evidence-based guideline recommendations for best practice increasingly important. The translation of basic scientific discoveries into clinically meaningful studies and then to evidence-based clinical practice guidelines (CPGs) or health policy is, however, not straightforward. CPGs are potentially the most influential publications as they aim to guide clinical decisions and impact patient outcomes; hence, current approaches to their development often fail scientific publication standards. Critical appraisal of CPGs has revealed that many do not involve laboratory professionals in formulating recommendations on the use of tests; the composition of the panel could influence the scope of guidelines and over-represent certain stakeholders’ views; numerous CPGs do not have rigorous evidence-based methodology and miss essential information important for the correct interpretation and application of laboratory results. PMID:27683490

  4. Technical baseline description for in situ vitrification laboratory test equipment

    SciTech Connect

    Beard, K.V.; Bonnenberg, R.W.; Watson, L.R.

    1991-09-01

    IN situ vitrification (ISV) has been identified as possible waste treatment technology. ISV was developed by Pacific Northwest Laboratory (PNL), Richland, Washington, as a thermal treatment process to treat contaminated soils in place. The process, which electrically melts and dissolves soils and associated inorganic materials, simultaneously destroys and/or removes organic contaminants while incorporating inorganic contaminants into a stable, glass-like residual product. This Technical Baseline Description has been prepared to provide high level descriptions of the design of the Laboratory Test model, including all design modifications and safety improvements made to data. Furthermore, the Technical Baseline Description provides a basic overview of the interface documents for configuration management, program management interfaces, safety, quality, and security requirements. 8 figs.

  5. Occupant Kinematics in Laboratory Rollover Tests: PMHS Response.

    PubMed

    Lessley, David J; Riley, Patrick; Zhang, Qi; Foltz, Patrick; Overby, Brian; Heltzel, Sara; Sochor, Mark; Crandall, Jeff; Kerrigan, Jason R

    2014-11-01

    The objective of the current study was to characterize the whole-body kinematic response of restrained PMHS in controlled laboratory rollover tests. A dynamic rollover test system (DRoTS) and a parametric vehicle buck were used to conduct 36 rollover tests on four adult male PMHS with varied test conditions to study occupant kinematics during the rollover event. The DRoTS was used to drop/catch and rotate the test buck, which replicated the occupant compartment of a typical mid-sized SUV, around its center of gravity without roof-to-ground contact. The studied test conditions included a quasi-static inversion (4 tests), an inverted drop and catch that produced a 3 g vertical deceleration (4 tests), a pure dynamic roll at 360 degrees/second (11 tests), and a roll with a superimposed drop and catch produced vertical deceleration (17 tests). Each PMHS was restrained with a three-point belt and was tested in both leading-side and trailing-side front-row seating positions. Whole-body kinematics were measured using a 3D motion capture system that quantified occupant displacement relative to the vehicle buck for the X-axis (longitudinal), Y-axis (lateral), and Z-axis (vertical) directions. Additionally the spine was divided into five segments to describe intrasegmental kinematics of the spine, including segment rotations as well as spinal extension and compression. The reported data represent the most complete set of kinematic response targets for a restrained occupant in a variety of dynamic rollover conditions, and are immediately useful for efforts to evaluate and improve existing ATDs and computational models for use in the rollover crash environment.

  6. How to test NISP instrument for EUCLID mission in laboratory

    NASA Astrophysics Data System (ADS)

    Costille, A.; Carle, Michael; Fabron, Christophe; Prieto, Eric; Beaumont, Florent; Jessen, Niels-Christian; Jakobsen, Peter; Sørensen, Anton N.; Andersen, Michael I.; Grupp, Frank; Maciaszek, Thierry; Ealet, Anne; Gillard, William; Clemens, Jean-Claude

    2016-07-01

    The ESA mission Euclid is designed to explore the dark side of the Universe. The NISP (Near Infrared Spectro- Photometer) is one of its two instruments operating in the near-IR spectral region (0.9-2μm), that will be fully integrated and tested at Laboratory d'Astrophysique de Marseille (LAM) under vacuum and thermal conditions. The test campaign will regroup functional tests, performance tests, calibration procedure validation and observations scenario test. One of the main objectives of the test campaign will be the measurement of the focus position of NISP with respect to the EUCLID object plane. To achieve these tests campaign, a global Ground Support Equipment (GSE) called the Verification Ground System (VGS) has to be developed. It will be a complex set of GSE integrated in ERIOS chamber made of: a telescope simulator to simulate the EUCLID telescope and to inject light into NISP, a thermal environment to be used for NISP thermal balance and verification, a sets of mechanical interfaces to align all the parts into ERIOS chamber, the NISP Electrical GSE (EGSE) to control the instrument during the test and a metrology system to measure the positions of the components during the test. We will present the preliminary design and concepts of the VGS and we will show the main difficulties we have to deal with: design of thermal environment at 80K with 4mK stability, the development of a metrology system in vacuum, knowledge of the focus position within 150μm in cold, etc. The main objectives of the NISP test will be explained and how the VGS responds to the test requirement.

  7. Laboratory Performance Testing of Residential Window Air Conditioners

    SciTech Connect

    Winkler, J.; Booten, C.; Christensen, D.; Tomerlin, J.

    2013-03-01

    Window air conditioners are the dominant cooling product for residences, in terms of annual unit sales. They are inexpensive, portable and can be installed by the owner. For this reason, they are an attractive solution for supplemental cooling, for retrofitting air conditioning into a home which lacks ductwork, and for renters. Window air conditioners for sale in the United States are required to meet very modest minimum efficiency standards. Four window air conditioners' performance were tested in the Advanced HVAC Systems Laboratory on NREL's campus in Golden, CO. In order to separate and study the refrigerant system's performance, the unit's internal leakage pathways, the unit's fanforced ventilation, and the leakage around the unit resulting from installation in a window, a series of tests were devised that focused on each aspect of the unit's performance. These tests were designed to develop a detailed performance map to determine whole-house performance in different climates. Even though the test regimen deviated thoroughly from the industry-standard ratings test, the results permit simple calculation of an estimated rating for both capacity and efficiency that would result from a standard ratings test. Using this calculation method, it was found that the three new air conditioners' measured performance was consistent with their ratings. This method also permits calculation of equivalent SEER for the test articles. Performance datasets were developed across a broad range of indoor and outdoor operating conditions, and used them to generate performance maps.

  8. 42 CFR 410.32 - Diagnostic x-ray tests, diagnostic laboratory tests, and other diagnostic tests: Conditions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 2 2013-10-01 2013-10-01 false Diagnostic x-ray tests, diagnostic laboratory tests, and other diagnostic tests: Conditions. 410.32 Section 410.32 Public Health CENTERS FOR MEDICARE... (SMI) BENEFITS Medical and Other Health Services § 410.32 Diagnostic x-ray tests, diagnostic...

  9. 42 CFR 410.32 - Diagnostic x-ray tests, diagnostic laboratory tests, and other diagnostic tests: Conditions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 2 2011-10-01 2011-10-01 false Diagnostic x-ray tests, diagnostic laboratory tests, and other diagnostic tests: Conditions. 410.32 Section 410.32 Public Health CENTERS FOR MEDICARE... (SMI) BENEFITS Medical and Other Health Services § 410.32 Diagnostic x-ray tests, diagnostic...

  10. 42 CFR 410.32 - Diagnostic x-ray tests, diagnostic laboratory tests, and other diagnostic tests: Conditions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 2 2012-10-01 2012-10-01 false Diagnostic x-ray tests, diagnostic laboratory tests, and other diagnostic tests: Conditions. 410.32 Section 410.32 Public Health CENTERS FOR MEDICARE... (SMI) BENEFITS Medical and Other Health Services § 410.32 Diagnostic x-ray tests, diagnostic...

  11. 42 CFR 410.32 - Diagnostic x-ray tests, diagnostic laboratory tests, and other diagnostic tests: Conditions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 2 2014-10-01 2014-10-01 false Diagnostic x-ray tests, diagnostic laboratory tests, and other diagnostic tests: Conditions. 410.32 Section 410.32 Public Health CENTERS FOR MEDICARE... (SMI) BENEFITS Medical and Other Health Services § 410.32 Diagnostic x-ray tests, diagnostic...

  12. Digital Audio Radio Broadcast Systems Laboratory Testing Nearly Complete

    NASA Technical Reports Server (NTRS)

    2005-01-01

    Radio history continues to be made at the NASA Lewis Research Center with the completion of phase one of the digital audio radio (DAR) testing conducted by the Consumer Electronics Group of the Electronic Industries Association. This satellite, satellite/terrestrial, and terrestrial digital technology will open up new audio broadcasting opportunities both domestically and worldwide. It will significantly improve the current quality of amplitude-modulated/frequency-modulated (AM/FM) radio with a new digitally modulated radio signal and will introduce true compact-disc-quality (CD-quality) sound for the first time. Lewis is hosting the laboratory testing of seven proposed digital audio radio systems and modes. Two of the proposed systems operate in two modes each, making a total of nine systems being tested. The nine systems are divided into the following types of transmission: in-band on-channel (IBOC), in-band adjacent-channel (IBAC), and new bands. The laboratory testing was conducted by the Consumer Electronics Group of the Electronic Industries Association. Subjective assessments of the audio recordings for each of the nine systems was conducted by the Communications Research Center in Ottawa, Canada, under contract to the Electronic Industries Association. The Communications Research Center has the only CCIR-qualified (Consultative Committee for International Radio) audio testing facility in North America. The main goals of the U.S. testing process are to (1) provide technical data to the Federal Communication Commission (FCC) so that it can establish a standard for digital audio receivers and transmitters and (2) provide the receiver and transmitter industries with the proper standards upon which to build their equipment. In addition, the data will be forwarded to the International Telecommunications Union to help in the establishment of international standards for digital audio receivers and transmitters, thus allowing U.S. manufacturers to compete in the

  13. Prototype dish testing and analysis at Sandia National Laboratories

    NASA Astrophysics Data System (ADS)

    Grossman, J. W.; Houser, R. M.; Erdman, W. W.

    1991-12-01

    During the past year, Sandia National Laboratories performed on-sun testing of several dish concentrator concepts. These tests were undertaken at the National Solar Thermal Test Facility (NSTTF). Two of the tests were performed in support of the DOE Concentrator Receiver Development Program. The first was on-sun testing of the single-element stretched-membrane dish; this 7-meter diameter dish uses a single preformed metal membrane with an aluminized polyester optical surface and shows potential for future dish-Stirling systems. The next involved two prototype facets from the Faceted Stretched-Membrane Dish Program. These facets, representing competitive design concepts, are closest to commercialization. Five 1-meter triangular facets were tested on-sun as part of the development program for a solar dynamic system on Space Station Freedom. While unique in character, all the tests utilized the Beam Characterization System (BCS) as the main measurement tool and all were analyzed using the Sandia-developed CIRCE2 computer code. The BCS is used to capture and digitize an image of the reflected concentrator beam that is incident on a target surface. The CIRCE2 program provides a computational tool, which when given the geometry of the concentrator and target as well as other design parameters will predict the flux distribution of the reflected beam. One of these parameters, slope error, is the variable that has a major effect in determining the quality of the reflected beam. The methodology used to combine these two tools to predict uniform slope errors for the dishes is discussed in this document. As the Concentrator Development Programs continue, Sandia will test and evaluate two prototype dish systems. The first, the faceted stretched-membrane dish, is expected to be tested in 1992, followed by the full-scale single-element stretched-membrane dish in 1993. These tests will use the tools and methodology discussed in this document.

  14. TRITIUM LABORATORY, TRA666, INTERIOR. DETAIL OF TEST LOOP PIPING. INL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    TRITIUM LABORATORY, TRA-666, INTERIOR. DETAIL OF TEST LOOP PIPING. INL NEGATIVE NO. HD30-1-3. Mike Crane, Photographer, 6/2001 - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

  15. Clinical and Laboratory Testing for Trichomonas vaginalis Infection

    PubMed Central

    2015-01-01

    Trichomonas vaginalis infection is highly prevalent in the United States and worldwide. Traditional clinical diagnostic methods fail to identify more than half of these infections that, if left untreated, can result in adverse pregnancy outcomes and an exacerbated risk of both acquisition and transmission of HIV. Women bear a disproportionate amount of the burden of these infections, and testing among populations at risk for this disease should be provided. Molecular technologies have expanded our capacity for laboratory-based detection of infection and can be used on samples already being collected for chlamydia/gonorrhea screening. PMID:26491181

  16. Retrofitting Combined Space and Water Heating Systems: Laboratory Tests

    SciTech Connect

    Schoenbauer, B.; Bohac, D.; Huelman, P.; Olson, R.; Hewitt, M.

    2012-10-01

    Better insulated and tighter homes can often use a single heating plant for both space and domestic water heating. These systems, called dual integrated appliances (DIA) or combination systems, can operate at high efficiency and eliminate combustion safety issues associated by using a condensing, sealed combustion heating plant. Funds were received to install 400 DIAs in Minnesota low-income homes. The NorthernSTAR DIA laboratory was created to identify proper system components, designs, operating parameters, and installation procedures to assure high efficiency of field installed systems. Tests verified that heating loads up to 57,000 Btu/hr can be achieved with acceptable return water temperatures and supply air temperatures.

  17. Retrofitting Combined Space and Water Heating Systems. Laboratory Tests

    SciTech Connect

    Schoenbauer, B.; Bohac, D.; Huelman, P.; Olsen, R.; Hewett, M.

    2012-10-01

    Better insulated and tighter homes can often use a single heating plant for both space and domestic water heating. These systems, called dual integrated appliances (DIA) or combination systems, can operate at high efficiency and eliminate combustion safety issues associated by using a condensing, sealed combustion heating plant. Funds were received to install 400 DIAs in Minnesota low-income homes. The NorthernSTAR DIA laboratory was created to identify proper system components, designs, operating parameters, and installation procedures to assure high efficiency of field installed systems. Tests verified that heating loads up to 57,000 Btu/hr can be achieved with acceptable return water temperatures and supply air temperatures.

  18. Feasibility study of an orbiting laboratory for testing CSI technology

    NASA Technical Reports Server (NTRS)

    Bicos, Andrew S.; Loboda, Gregory G.

    1993-01-01

    A concept for an orbiting laboratory for testing Controls-Structures Integration (CSI) technology is described. The CSI-Star concept reflects a lower cost, higher risk approach. The concept supports demonstration and validation testing for critical CSI technologies at a cost of $20M to $26M with a 1-year reliability of approximately 0.9. The Ball Aerospace QuickStar bus is the carrier for the CSI test article. QuickStar is launched as a secondary payload on the McDonnell Douglas Delta 2. The QuickStar/Delta 2 approach is flight proven. The CSI test article is a 20 foot, 1 Hz, truss beam which is deployed from the QuickStar bus. The test article is well instrumented for quality system identification. The laboratory provides three layers of active control consisting of global vibration suppression along the truss beam, vibration isolation between the beam and instrument platforms, and vibration compensation through the use of gimbaled platforms which point lasers relative to optical sensor targets. The configuration simulates the dynamics of multi-instrument science platforms such as those of the Earth Observation System (EOS) while maintaining strong ties to astrophysics missions such as the Optical Interferometer. Uplink/downlink services and a reprogrammable computer provide flexibility for long-term investigations by members of the CSI community (NASA, DoD, academia, and industry). CSI-Star fills the gap between short-term experiments, which have been conducted primarily on the Shuttle, and future science missions which require the technology. The on-orbit maturity of CSI technology must be established to obtain acceptance by project managers and to promote injection of the technology into future science missions.

  19. Feasibility study of an orbiting laboratory for testing CSI technology

    NASA Astrophysics Data System (ADS)

    Bicos, Andrew S.; Loboda, Gregory G.

    1993-08-01

    A concept for an orbiting laboratory for testing Controls-Structures Integration (CSI) technology is described. The CSI-Star concept reflects a lower cost, higher risk approach. The concept supports demonstration and validation testing for critical CSI technologies at a cost of $20M to $26M with a 1-year reliability of approximately 0.9. The Ball Aerospace QuickStar bus is the carrier for the CSI test article. QuickStar is launched as a secondary payload on the McDonnell Douglas Delta 2. The QuickStar/Delta 2 approach is flight proven. The CSI test article is a 20 foot, 1 Hz, truss beam which is deployed from the QuickStar bus. The test article is well instrumented for quality system identification. The laboratory provides three layers of active control consisting of global vibration suppression along the truss beam, vibration isolation between the beam and instrument platforms, and vibration compensation through the use of gimbaled platforms which point lasers relative to optical sensor targets. The configuration simulates the dynamics of multi-instrument science platforms such as those of the Earth Observation System (EOS) while maintaining strong ties to astrophysics missions such as the Optical Interferometer. Uplink/downlink services and a reprogrammable computer provide flexibility for long-term investigations by members of the CSI community (NASA, DoD, academia, and industry). CSI-Star fills the gap between short-term experiments, which have been conducted primarily on the Shuttle, and future science missions which require the technology. The on-orbit maturity of CSI technology must be established to obtain acceptance by project managers and to promote injection of the technology into future science missions.

  20. Laboratory test data on the stability of the STIS MAMAs

    NASA Technical Reports Server (NTRS)

    Joseph, Charles L.

    1997-01-01

    STIS has two MAMA detectors systems with distinctly different tube configurations. The first (designated BAND 1) has an opaque CsI photocathode deposited on the microchannel plate (MCP) providing wavelength coverage from 1150A to 1700A. The other MAMA (designated BAND 2) has a semitransparent CS2Te photocathode deposited on the faceplate in close proximity to the input of the MCP. It covers the 1650A to 3100A bandpass and serves as a backup for the short wavelength detector. Laboratory test data indicate that both of these detectors have good sensitivity, have good uniformity and provide stable response, making each capable of collecting data with a signal-to-noise ratio in excess of 100 per Space Telescope Imaging Spectrograph (STIS) optical resolution element. Over a multiyear development effort, a substantial body of laboratory test data (more than 6 GBytes spanning more than 6 years of collection) has accumulated on more than a dozen fabricated tubes. These tests even included a few destructive evaluations to examine the limitations and operating life. In addition, analyses where conducted regarding impact caused by the specified electronic tolerances and expected changes in the Hubble Space Telescope (HST) thermal environment. Perhaps the simplest test of stability is to collect a sequence of images, each with a uniform illumination, and use these individual "flat fields" to remove the pixel-to-pixel sensitivity in the other flat fields. These sequences typically spanned 3-5 weeks of time. The detectors are very stable, allowing the pixel-to-pixel sensitivity to be removed with good precision. The STIS specification for stability is 1% (sufficient for data with a S/N = 100) over a 1 week period and 2% over 30 days. All Engineering Model Units as well as Flight Detectors tested exceeded this specification.

  1. Laboratory Testing of Waste Isolation Pilot Plant Surrogate Waste Materials

    NASA Astrophysics Data System (ADS)

    Broome, S.; Bronowski, D.; Pfeifle, T.; Herrick, C. G.

    2011-12-01

    The Waste Isolation Pilot Plant (WIPP) is a U.S. Department of Energy geological repository for the permanent disposal of defense-related transuranic (TRU) waste. The waste is emplaced in rooms excavated in the bedded Salado salt formation at a depth of 655 m below the ground surface. After emplacement of the waste, the repository will be sealed and decommissioned. WIPP Performance Assessment modeling of the underground material response requires a full and accurate understanding of coupled mechanical, hydrological, and geochemical processes and how they evolve with time. This study was part of a broader test program focused on room closure, specifically the compaction behavior of waste and the constitutive relations to model this behavior. The goal of this study was to develop an improved waste constitutive model. The model parameters are developed based on a well designed set of test data. The constitutive model will then be used to realistically model evolution of the underground and to better understand the impacts on repository performance. The present study results are focused on laboratory testing of surrogate waste materials. The surrogate wastes correspond to a conservative estimate of the degraded containers and TRU waste materials after the 10,000 year regulatory period. Testing consists of hydrostatic, uniaxial, and triaxial tests performed on surrogate waste recipes that were previously developed by Hansen et al. (1997). These recipes can be divided into materials that simulate 50% and 100% degraded waste by weight. The percent degradation indicates the anticipated amount of iron corrosion, as well as the decomposition of cellulosics, plastics, and rubbers. Axial, lateral, and volumetric strain and axial and lateral stress measurements were made. Two unique testing techniques were developed during the course of the experimental program. The first involves the use of dilatometry to measure sample volumetric strain under a hydrostatic condition. Bulk

  2. Genetic counselor review of genetic test orders in a reference laboratory reduces unnecessary testing.

    PubMed

    Miller, Christine E; Krautscheid, Patti; Baldwin, Erin E; Tvrdik, Tatiana; Openshaw, Amanda S; Hart, Kim; Lagrave, Danielle

    2014-05-01

    Genetic tests are routinely ordered by health care providers (HCPs) within a wide range of medical specialties. Many providers have limited knowledge or experience with ordering and interpreting genetic tests; thus, test order errors are common. Rigorous review of genetic test orders by genetic counselors (GCs) can provide a direct financial benefit to medical institutions, patients and insurers. GCs at ARUP (Associated Regional University Pathologists) Laboratories routinely perform a preanalytic assessment of complex molecular genetic test orders that includes reviewing clinical and family history information and considering the clinical utility and cost-effectiveness of ordered tests. GCs contact the ordering institution and/or HCP as needed to collect additional clinical information and confirm the test order or suggest alternative testing based on the provided information. A retrospective review of the GC-facilitated test changes over a 21-month period at ARUP laboratories was performed. Approximately 26% of all requests for complex genetic tests assessing germ line mutations were changed following GC review. Testing fees associated with canceled tests were summed to estimate the cost-savings resulting from GC-facilitated test reviews. The test review process resulted in an average reduction in charges to the referring institutions of $48,000.00 per month. GC review of genetic test orders for appropriateness and clinical utility reduces healthcare costs to hospitals, insurers, and patients.

  3. Vestibular Migraine in Children and Adolescents: Clinical Findings and Laboratory Tests

    PubMed Central

    Langhagen, Thyra; Lehrer, Nicole; Borggraefe, Ingo; Heinen, Florian; Jahn, Klaus

    2015-01-01

    Introduction: Vestibular migraine (VM) is the most common cause of episodic vertigo in children. We summarize the clinical findings and laboratory test results in a cohort of children and adolescents with VM. We discuss the limitations of current classification criteria for dizzy children. Methods: A retrospective chart analysis was performed on 118 children with migraine related vertigo at a tertiary care center. Patients were grouped in the following categories: (1) definite vestibular migraine (dVM); (2) probable vestibular migraine (pVM); (3) suspected vestibular migraine (sVM); (4) benign paroxysmal vertigo (BPV); and (5) migraine with/without aura (oM) plus vertigo/dizziness according to the International Classification of Headache Disorders, 3rd edition (beta version). Results: The mean age of all patients was 12 ± 3 years (range 3–18 years, 70 females). 36 patients (30%) fulfilled criteria for dVM, 33 (28%) for pVM, 34 (29%) for sVM, 7 (6%) for BPV, and 8 (7%) for oM. Somatoform vertigo (SV) co-occurred in 27% of patients. Episodic syndromes were reported in 8%; the family history of migraine was positive in 65%. Mild central ocular motor signs were found in 24% (most frequently horizontal saccadic pursuit). Laboratory tests showed that about 20% had pathological function of the horizontal vestibulo-ocular reflex, and almost 50% had abnormal postural sway patterns. Conclusion: Patients with definite, probable, and suspected VM do not differ in the frequency of ocular motor, vestibular, or postural abnormalities. VM is the best explanation for their symptoms. It is essential to establish diagnostic criteria in clinical studies. In clinical practice, however, the most reasonable diagnosis should be made in order to begin treatment. Such a procedure also minimizes the fear of the parents and children, reduces the need to interrupt leisure time and school activities, and prevents the development of SV. PMID:25674076

  4. CONTROL TESTING OF THE UK NATIONAL NUCLEAR LABORATORY'S RADBALL TECHNOLOGY AT SAVANNAH RIVER NATIONAL LABORATORY

    SciTech Connect

    Farfan, E.

    2009-11-23

    The UK National Nuclear Laboratory (NNL) has developed a remote, non-electrical, radiation-mapping device known as RadBall (patent pending), which offers a means to locate and quantify radiation hazards and sources within contaminated areas of the nuclear industry. To date, the RadBall has been deployed in a number of technology trials in nuclear waste reprocessing plants at Sellafield in the UK. The trials have demonstrated the successful ability of the RadBall technology to be deployed and retrieved from active areas. The positive results from these initial deployment trials and the anticipated future potential of RadBall have led to the NNL partnering with the Savannah River National Laboratory (SRNL) to further underpin and strengthen the technical performance of the technology. RadBall consists of a colander-like outer shell that houses a radiation-sensitive polymer sphere. It has no power requirements and can be positioned in tight or hard-to reach places. The outer shell works to collimate radiation sources and those areas of the polymer sphere that are exposed react, becoming increasingly less transparent, in proportion to the absorbed dose. The polymer sphere is imaged in an optical-CT scanner which produces a high resolution 3D map of optical attenuation coefficients. Subsequent analysis of the optical attenuation maps provides information on the spatial distribution and strength of the sources in a given area forming a 3D characterization of the area of interest. This study completed at SRNL addresses key aspects of the testing of the RadBall technology. The first set of tests was performed at Savannah River Nuclear Solutions Health Physics Instrument Calibration Laboratory (HPICL) using various gamma-ray sources and an x-ray machine with known radiological characteristics. The objective of these preliminary tests was to identify the optimal dose and collimator thickness. The second set of tests involved a highly contaminated hot cell. The objective of

  5. DNA testing of sexual assault evidence: the laboratory perspective.

    PubMed

    Burg, Abby; Kahn, Roger; Welch, Katherine

    2011-09-01

    The availability of DNA testing has dramatically changed the way that crimes are investigated. DNA results can link offenders to their crimes, exonerate wrongfully accused individuals, identify mass fatality victims and more. In the case of sexual assault, DNA evidence alone cannot prove that a sexual assault has occurred. DNA analysis can only reveal whether a person's DNA is, or is not, present. In this paper, the authors provide readers with an overview of the advantages and limitations of DNA analysis, the importance of proper evidence collection, the technologies available, and the amount of sample needed for testing. Through proper evidence collection and quality laboratory services, the full value of DNA will be realized.

  6. The laboratory station for tyres grip testing on different surfaces

    NASA Astrophysics Data System (ADS)

    Kalinowski, K.; Grabowik, C.; Janik, W.; Ćwikła, G.; Skowera, M.

    2015-11-01

    The paper presents the conception of the device for tyre grip testing in the laboratory conditions. The main purpose is to provide a device working in confined spaces, which enables rapid changes of the tested samples of the road surfaces. Among the key assumptions the minimization of the device dimensions and the relative ease of transportation and mobility - the ability to quick assemble and disassemble were also assumed. The main components of the projected workstation includes: the replaceable platform for mounting samples of a road surface, the roller conveyor, the drive of the platform, the wheel mounting assembly and the axial force measuring system. At the design the station a morphological structure method has been used, particular elements have been optimized individually.

  7. 78 FR 46996 - Current List of Laboratories and Instrumented Initial Testing Facilities Which Meet Minimum...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-02

    ... HUMAN SERVICES Substance Abuse and Mental Health Services Administration Current List of Laboratories... Testing for Federal Agencies AGENCY: Substance Abuse and Mental Health Services Administration, HHS... Laboratory Accreditation Program for Substance Abuse (LAPSA) effective May 12, 1998. Laboratories...

  8. 76 FR 161 - Current List of Laboratories and Instrumented Initial Testing Facilities Which Meet Minimum...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-03

    ... HUMAN SERVICES Substance Abuse and Mental Health Services Administration Current List of Laboratories... Testing for Federal Agencies AGENCY: Substance Abuse and Mental Health Services Administration, HHS... Laboratory Accreditation Program for Substance Abuse (LAPSA) effective May 12, 1998. Laboratories...

  9. Association of black race with follow-up of an abnormal prostate-specific antigen test.

    PubMed

    Turner, Barbara J; Mavandadi, Shahrzad; Weiner, Mark G

    2011-02-01

    Delayed evaluation after a clearly abnormal prostate-specific antigen (PSA) result may contribute to more advanced prostate cancer at diagnosis in black men. In 46 primary care practices over a period of 4.5 years, we studied men aged more than 50 years without known prostate cancer who had a PSA of at least 10.0 ng/mL for the first time. PSA follow-up included: a urology appointment, a new prostate diagnosis, or repeat PSA test. Cox proportional hazards models assessed time to follow-up, adjusting for demographic, clinical, and health care factors with censoring at a time that represents excessive delay (200 days). Among all 724 study men (27% black), delay until PSA follow-up averaged 115.2 days (+/- 79.7 d) and the unadjusted hazard ratio (HR) for follow-up was shorter for black men than nonblack men (HR, 1.23; 95% CI, 1.00-1.51). However, black men were more likely to have had prior urology care and had higher index PSA levels than other men; both factors were associated with shorter follow-up. After adjustment, delay did not differ for black vs nonblack race (HR, 1.05; 95% Cl, 0.78-1.43) but men aged at least 75 years had a longer delay than men aged 74 years or less (HR, 0.72; 95% CI, 0.59-0.89). Despite black men having greater risk of advanced prostate disease at diagnosis and better linkage to urologic care, follow-up was delayed, on average, by more than 3 months and did not differ by race. These results reveal a potentially important, remediable factor to improve prostate cancer prevention and care for black men.

  10. A simple measuring device for laboratory indentation tests on cartilage.

    PubMed

    Koeller, Wolfgang; Kunow, Julius; Ostermeyer, Oliver; Stomberg, Peter; Boos, Carsten; Russlies, Martin

    2008-04-01

    Mechanical testing of articular cartilage and repair tissue enables judgment of their capacity in withstanding mechanical loading. In the past, different methods have been developed requiring a complex technical setup and extensive data analysis. Therefore, the aim of the present project was to build up a simple measuring apparatus for laboratory indentation tests. The device consists of an incremental optical displacement transducer with a sleeve bearing guided plunger and a spherical tip made of polished steel (radius: 0.75 or 1.5 mm), a sensitive load cell and a stiff frame. The indentation force results from the plunger's gravity plus the force of the spring inside the displacement transducer and levels at 0.170 N or 0.765 N. The displacement transducer is fixed to the frame via the load cell that enables one to detect the initial contact of the tip with the tissue. The load cell has a standard uncertainty of 2 mN and the displacement transducer of 1 microm. From indentation-creep tests, a "0.25-s elastic modulus" is calculated. Measurements on thin rubber sheets were carried out to determine the quality of the measuring device. Compression tests on cylinders made of these rubber sheets yielded control data, and a good agreement with the "0.25-s elastic modulus" was found. Indentation tests on cartilage at different sites of sheep femoral condyles yielded a very good repeatability of the measurement results (+/-7.5%).

  11. Laboratory and field testing of improved geothermal rock bits

    SciTech Connect

    Hendrickson, R.R.; Jones, A.H.; Winzenried, R.W.; Maish, A.B.

    1980-07-01

    The development and testing of 222 mm (8-3/4 inch) unsealed, insert type, medium hard formation, high-temperature bits are described. The new bits were fabricated by substituting improved materials in critical bit components. These materials were selected on bases of their high temperature properties, machinability, and heat treatment response. Program objectives required that both machining and heat treating could be accomplished with existing rock bit production equipment. Two types of experimental bits were subjected to laboratory air drilling tests at 250/sup 0/C (482/sup 0/F) in cast iron. These tests indicated field testing could be conducted without danger to the hole, and that bearing wear would be substantially reduced. Six additional experimental bits, and eight conventional bits were then subjected to air drilling a 240/sup 0/C (464/sup 0/F) in Francisan Graywacke at The Geysers, CA. The materials selected improved roller wear by 200%, friction-pin wear by 150%, and lug wear by 150%. Geysers drilling performances compared directly to conventional bits indicate that in-gage drilling life was increased by 70%. All bits at The Geysers are subjected to reaming out-of-gage hole prior to drilling. Under these conditions the experimental bits showed a 30% increase in usable hole over the conventional bits. These tests demonstrated a potential well cost reduction of 4 to 8%. Savings of 12% are considered possible with drilling procedures optimized for the experimental bits.

  12. Experimental laboratory system to generate high frequency test environments

    SciTech Connect

    Gregory, D.L.; Paez, T.L.

    1991-01-01

    This is an extension of two previous analytical studies to investigate a technique for generating high frequency, high amplitude vibration environments. These environments are created using a device attached to a common vibration exciter that permits multiple metal on metal impacts driving a test surface. These analytical studies predicted that test environments with an energy content exceeding 10 kHz could be achieved using sinusoidal and random shaker excitations. The analysis predicted that chaotic vibrations yielding random like test environments could be generated from sinusoidal inputs. In this study, a much simplified version of the proposed system was fabricated and tested in the laboratory. Experimental measurements demonstrate that even this simplified system, utilizing a single impacting object, can generate environments on the test surface with significant frequency content in excess of 40 kHz. Results for sinusoidal shaker inputs tuned to create chaotic impact response are shown along with the responses due to random vibration shaker inputs. The experiments and results are discussed. 4 refs., 5 figs.

  13. SINGLE EVENT EFFECTS TEST FACILITY AT OAK RIDGE NATIONAL LABORATORY

    SciTech Connect

    Riemer, Bernie; Gallmeier, Franz X; Dominik, Laura J

    2015-01-01

    Increasing use of microelectronics of ever diminishing feature size in avionics systems has led to a growing Single Event Effects (SEE) susceptibility arising from the highly ionizing interactions of cosmic rays and solar particles. Single event effects caused by atmospheric radiation have been recognized in recent years as a design issue for avionics equipment and systems. To ensure a system meets all its safety and reliability requirements, SEE induced upsets and potential system failures need to be considered, including testing of the components and systems in a neutron beam. Testing of ICs and systems for use in radiation environments requires the utilization of highly advanced laboratory facilities that can run evaluations on microcircuits for the effects of radiation. This paper provides a background of the atmospheric radiation phenomenon and the resulting single event effects, including single event upset (SEU) and latch up conditions. A study investigating requirements for future single event effect irradiation test facilities and developing options at the Spallation Neutron Source (SNS) is summarized. The relatively new SNS with its 1.0 GeV proton beam, typical operation of 5000 h per year, expertise in spallation neutron sources, user program infrastructure, and decades of useful life ahead is well suited for hosting a world-class SEE test facility in North America. Emphasis was put on testing of large avionics systems while still providing tunable high flux irradiation conditions for component tests. Makers of ground-based systems would also be served well by these facilities. Three options are described; the most capable, flexible, and highest-test-capacity option is a new stand-alone target station using about one kW of proton beam power on a gas-cooled tungsten target, with dual test enclosures. Less expensive options are also described.

  14. Congenital hypothyroidism in a kitten resulting in decreased IGF-I concentration and abnormal liver function tests.

    PubMed

    Quante, Saskia; Fracassi, Federico; Gorgas, Daniela; Kircher, Patrick R; Boretti, Felicitas S; Ohlerth, Stefanie; Reusch, Claudia E

    2010-06-01

    A 7-month-old male kitten was presented with chronic constipation and retarded growth. Clinical examination revealed disproportional dwarfism with mild skeletal abnormalities and a palpable thyroid gland. The presumptive diagnosis of congenital hypothyroidism was confirmed by low serum total thyroxine (tT(4)) concentration prior to and after the administration of thyroid stimulation hormone (TSH), increased endogenous TSH concentration and abnormal thyroid scintigraphic scan. The kitten had abnormal liver function tests and decreased insulin-like growth factor 1 (IGF-1) concentration, both of which returned to normal in correspondence with an improvement of the clinical signs after 6 weeks of thyroxine therapy. Congenital hypothyroidism is a rare disease that may present with considerable variation in clinical manifestation. In cases in which clinical signs are ambiguous, disorders such as portosystemic shunt and hyposomatotropism have to be taken into account as differential diagnosis. As hypothyroidism may be associated with abnormal liver function tests and low IGF-1 concentrations, test results have to be interpreted carefully.

  15. Women's understanding of abnormal cervical smear test results: a qualitative interview study.

    PubMed Central

    Kavanagh, A. M.; Broom, D. H.

    1997-01-01

    OBJECTIVE: To describe how women interpret their experiences of diagnosis and treatment of a cervical abnormality and how healthcare services for such women can be improved. DESIGN: Qualitative study using detailed individual interviews. SETTING: Australian gynaecology clinics. SUBJECTS: 29 Women who had a cervical cytological abnormality and who attended a gynaecologist. MAIN OUTCOME MEASURES: Women's views on their diagnosis and their information needs. RESULTS: Most women wanted to participate in decisions about their care but found it difficult to get the information they required from doctors because they were confused by what their doctors told them and felt unable to ask questions in the consultation. Medical terms such as wart virus and precancer were difficult to understand. Not being able to see their cervix also made it hard for women to understand what their abnormality meant and what treatment entailed. Most women tried to make sense of their abnormality in the context of their everyday lives. For some women their gynaecological care was not consistent with the way they understood their abnormality. CONCLUSIONS: The inherent power structure of medical practice combined with time pressures often make it difficult for doctors to give the detailed information and reassurance patients need when a diagnosis is distressing or when investigation and treatment are strange and upsetting. PMID:9161314

  16. 5. Exterior view of Components Test Laboratory (T27), looking northwest. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. Exterior view of Components Test Laboratory (T-27), looking northwest. The building wing on the left houses Test Cell 10 (environmental), and that on the right houses Test Cell 9 (fuel) and the fuel storage pit or vault. - Air Force Plant PJKS, Systems Integration Laboratory, Components Test Laboratory, Waterton Canyon Road & Colorado Highway 121, Lakewood, Jefferson County, CO

  17. 4. Exterior view of Components Test Laboratory (T27), looking northeast. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. Exterior view of Components Test Laboratory (T-27), looking northeast. The building wing on the left houses Test Cell 8 (oxidizer) and the oxidizer storage pit or vault, and that on the right houses Test Cell 10 (environmental). - Air Force Plant PJKS, Systems Integration Laboratory, Components Test Laboratory, Waterton Canyon Road & Colorado Highway 121, Lakewood, Jefferson County, CO

  18. 42 CFR 493.1447 - Condition: Laboratories performing high complexity testing; technical supervisor.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... testing; technical supervisor. 493.1447 Section 493.1447 Public Health CENTERS FOR MEDICARE & MEDICAID... REQUIREMENTS Personnel for Nonwaived Testing Laboratories Performing High Complexity Testing § 493.1447 Condition: Laboratories performing high complexity testing; technical supervisor. The laboratory must have...

  19. 42 CFR 493.1447 - Condition: Laboratories performing high complexity testing; technical supervisor.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... testing; technical supervisor. 493.1447 Section 493.1447 Public Health CENTERS FOR MEDICARE & MEDICAID... REQUIREMENTS Personnel for Nonwaived Testing Laboratories Performing High Complexity Testing § 493.1447 Condition: Laboratories performing high complexity testing; technical supervisor. The laboratory must have...

  20. 42 CFR 493.1467 - Condition: Laboratories performing high complexity testing; cytology general supervisor.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... testing; cytology general supervisor. 493.1467 Section 493.1467 Public Health CENTERS FOR MEDICARE... LABORATORY REQUIREMENTS Personnel for Nonwaived Testing Laboratories Performing High Complexity Testing § 493.1467 Condition: Laboratories performing high complexity testing; cytology general supervisor. For...

  1. 42 CFR 493.1467 - Condition: Laboratories performing high complexity testing; cytology general supervisor.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... testing; cytology general supervisor. 493.1467 Section 493.1467 Public Health CENTERS FOR MEDICARE... LABORATORY REQUIREMENTS Personnel for Nonwaived Testing Laboratories Performing High Complexity Testing § 493.1467 Condition: Laboratories performing high complexity testing; cytology general supervisor. For...

  2. EVA Development and Verification Testing at NASA's Neutral Buoyancy Laboratory

    NASA Technical Reports Server (NTRS)

    Jairala, Juniper C.; Durkin, Robert; Marak, Ralph J.; Sipila, Stepahnie A.; Ney, Zane A.; Parazynski, Scott E.; Thomason, Arthur H.

    2012-01-01

    As an early step in the preparation for future Extravehicular Activities (EVAs), astronauts perform neutral buoyancy testing to develop and verify EVA hardware and operations. Neutral buoyancy demonstrations at NASA Johnson Space Center's Sonny Carter Training Facility to date have primarily evaluated assembly and maintenance tasks associated with several elements of the International Space Station (ISS). With the retirement of the Shuttle, completion of ISS assembly, and introduction of commercial players for human transportation to space, evaluations at the Neutral Buoyancy Laboratory (NBL) will take on a new focus. Test objectives are selected for their criticality, lack of previous testing, or design changes that justify retesting. Assembly tasks investigated are performed using procedures developed by the flight hardware providers and the Mission Operations Directorate (MOD). Orbital Replacement Unit (ORU) maintenance tasks are performed using a more systematic set of procedures, EVA Concept of Operations for the International Space Station (JSC-33408), also developed by the MOD. This paper describes the requirements and process for performing a neutral buoyancy test, including typical hardware and support equipment requirements, personnel and administrative resource requirements, examples of ISS systems and operations that are evaluated, and typical operational objectives that are evaluated.

  3. Direct laboratory tensile testing of select yielding rock bolt systems

    SciTech Connect

    VandeKraats, J.D.; Watson, S.O.

    1996-08-01

    Yielding rock bolt support systems have been developed to accommodate ground movement in shifting ground such as in coal operations; in creeping ground such as salt, trona, and potash; and in swelling ground associated with some clays. These systems, designed to remain intact despite ground movement, should enhance mine safety and help contain costs in areas where rebolting of rigid non-yielding systems is typically required. Four such systems were tested in straight tensile pulls in the laboratory. They include the Slip Nut System from Dywidag Systems International USA, Inc., Ischebeck`s bolt mounted Titan Load Indicator, Rocky Mountain Bolt Company`s Yielding Cable Bolt, and a rock bolt installed variation of the yielding steel post developed by RE/SPEC Inc. The first two systems are currently marketed products and the latter two are prototype systems. Each system responds to load and displacement by yielding in an unique manner. All are designed to yield at predetermined loads. A description of each system and its yield function is provided. Each system was tested over its prescribed yield range in a test machine. At least five tests were performed on each system. Each system yielded and continued to provide support according to its design. Each shows promise for ground control use in shifting or creeping rock. This work helps to illustrate the comparative differences in performance between these specialized systems and the applications where they may be most useful.

  4. Current Concepts in Laboratory Testing to Guide Antimicrobial Therapy

    PubMed Central

    Jenkins, Stephen G.; Schuetz, Audrey N.

    2012-01-01

    Antimicrobial susceptibility testing (AST) is indicated for pathogens contributing to an infectious process that warrants antimicrobial therapy if susceptibility to antimicrobials cannot be predicted reliably based on knowledge of their identity. Such tests are most frequently used when the etiologic agents are members of species capable of demonstrating resistance to commonly prescribed antibiotics. Some organisms have predictable susceptibility to antimicrobial agents (ie, Streptococcus pyogenes to penicillin), and empirical therapy for these organisms is typically used. Therefore, AST for such pathogens is seldom required or performed. In addition, AST is valuable in evaluating the activity of new and experimental compounds and investigating the epidemiology of antimicrobial resistant pathogens. Several laboratory methods are available to characterize the in vitro susceptibility of bacteria to antimicrobial agents. When the nature of the infection is unclear and the culture yields mixed growth or usual microbiota (wherein the isolates usually bear little relationship to the actual infectious process), AST is usually unnecessary and results may, in fact, be dangerously misleading. Phenotypic methods for detection of specific antimicrobial resistance mechanisms are increasingly being used to complement AST (ie, inducible clindamycin resistance among several gram-positive bacteria) and to provide clinicians with preliminary direction for antibiotic selection pending results generated from standardized AST (ie, β-lactamase tests). In addition, molecular methods are being developed and incorporated by microbiology laboratories into resistance detection algorithms for rapid, sensitive assessment of carriage states of epidemiologically and clinically important pathogens, often directly from clinical specimens (ie, presence of vancomycin-resistant enterococci in fecal specimens). PMID:22386185

  5. Standard Hydrogen Test Protocols for the NREL Sensor Testing Laboratory (Brochure)

    SciTech Connect

    Not Available

    2011-12-01

    This brochure summarizes the test protocols used in the NREL Hydrogen Sensor Test Laboratory for the quantitative assessment of critical analytical performance specifications for hydrogen sensors. Researchers at the NREL Hydrogen Safety Sensor Test Laboratory developed a variety of test protocols to quantitatively assess critical analytical performance specifications for hydrogen sensors. Many are similar to, but typically more rigorous than, the test procedures mandated by ISO Standard 26142 (Hydrogen Detector for Stationary Applications). Specific protocols were developed for linear range, short-term stability, and the impact of fluctuations in temperature (T), pressure (P), relative humidity (RH), and chemical environment. Specialized tests (e.g., oxygen requirement) may also be performed. Hydrogen safety sensors selected for evaluation are subjected to a thorough regimen of test protocols, as described. Sensor testing is performed at NREL on custom-built sensor test fixtures. Environmental parameters such as T, P, RH, and gas composition are rigorously controlled and monitored. The NREL evaluations are performed on commercial hydrogen detectors, on emerging sensing technologies, and for end users to validate sensor performance for specific application needs. Test results and data are shared with the manufacturer or client via summary reports, teleconference phone calls, and, when appropriate, site visits to manufacturer facilities. Client representatives may also monitor NREL's operation while their technologies are being tested. Manufacturers may use test data to illustrate the analytical capability of their technologies and, more importantly, to guide future developments. NREL uses the data to assess technology gaps and deployment considerations. Per NREL Sensor Testing Laboratory policy, test results are treated as proprietary and are not shared with other manufacturers or other entities without permission. The data may be used by NREL in open publications

  6. Risk management in the preanalytical phase of laboratory testing.

    PubMed

    Lippi, Giuseppe; Guidi, Gian Cesare

    2007-01-01

    The clinical laboratory is no longer its own limited ecosystem, as it is increasingly integrated with patient care, assisting diagnosis, monitoring therapies and predicting clinical outcomes. Although efforts and resources are continuously focused to achieve a satisfactory degree of analytical quality, there is clear evidence that the preanalytical phase is much more vulnerable to uncertainties and accidents, which can substantially influence patient care. Most errors within the preanalytical phase result from system flaws and insufficient audit of the operators involved in specimen collection and handling responsibilities, leading to an unacceptable number of unsuitable specimens due to in vitro hemolysis, clotting, insufficient volume, wrong container, contamination and misidentification. A reliable approach to overcome this problem entails prediction of accidental events (exhaustive process analysis, reassessment and rearrangement of quality requirements, dissemination of operating guidelines and best-practice recommendations, reduction of complexity and error-prone activities, introduction of error-tracking systems and continuous monitoring of performances), an increase in and diversification of defenses (application of multiple and heterogeneous systems to identify non-conformities), and a decrease in vulnerability (implementation of reliable and objective detection systems and causal relation charts, education and training). This policy, which requires integration between requirements and design, full commitment and interdepartmental cooperation, should make laboratory activity more compliant to the inalienable paradigm of total quality in the testing process.

  7. Maize mono-digestion efficiency: results from laboratory tests.

    PubMed

    Ficara, Elena; Malpei, Francesca

    2011-01-01

    A laboratory experimental campaign was carried out in order to assess the optimal configuration for the anaerobic digestion of a mixture of sweet corn and ensiled maize. Batch hydrolysis tests were conducted at 35 and 55 °C and at four different particle sizes (2, 5, 20 and 50 mm) obtained by manual chopping and sieving. Chemical pre-treatment by 24 h incubation at various acid and alkaline pH was also considered for its potential to increase the maize methane yield. Results suggest that the hydrolytic phase proceeds significantly faster under thermophilic conditions. Significant differences in the solubilization rate were also observed when comparing coarse (20-50 mm) with fine (2-5 mm) particles, while 2 and 5 mm particles were solubilized at similar rates. No advantages from the chemical pre-treatment, in terms of solubilization efficiency and biomethanization potential were observed. According to these preliminary results, a two-stage semi-continuous laboratory plant consisting of a thermophilic hydrolytic reactor followed by a mesophilic methanogenic reactor was operated for 110 days. Steady state loading parameters were: influent concentration (maize mixture diluted in tap water) of 46 g VS/L, hydraulic retention time of 31 d, organic loading rate of 1.5 g VS/L/d. Alkalinity was dosed to the methanogenic reactor to avoid pH drops. Collected data allowed the average biodegradation efficiency to be estimated at around 60-65%.

  8. Evaluation of the Generalizability of the Number of Abnormal Scores and the Overall Test Battery Mean as Measures of Performance Validity to a Different Test Battery.

    PubMed

    Silk-Eglit, Graham M; Miele, Andrea S; Stenclik, Jessica H; Lynch, Julie K; McCaffrey, Robert J

    2015-01-01

    Davis, Axelrod, McHugh, Hanks, and Millis (2013) documented that in a battery of 25 tests, producing 15, 10, and 5 abnormal scores at 1, 1.5, and 2 standard deviations below the norm-referenced mean, respectively, and an overall test battery mean (OTBM) of T ≤ 38 accurately identifies performance invalidity. However, generalizability of these findings to other samples and test batteries remains unclear. This study evaluated the use of abnormal scores and the OTBM as performance validity measures in a different sample that was administered a 25-test battery that minimally overlapped with Davis et al.'s test battery. Archival analysis of 48 examinees with mild traumatic brain injury seen for medico-legal purposes was conducted. Producing 18 or more, 7 or more, and 5 or more abnormal scores at 1, 1.5, and 2 standard deviations below the norm-referenced mean, respectively, and an OTBM of T ≤ 40 most accurately classified examinees; however, using Davis et al.'s proposed cutoffs in the current sample maintained specificity at or near acceptable levels. Due to convergence across studies, producing ≥5 abnormal scores at 2 standard deviations below the norm-referenced mean is the most appropriate cutoff for clinical implementation; however, for batteries consisting of a different quantity of tests than 25, an OTBM of T ≤ 38 is more appropriate.

  9. Laboratory Testing of a Phased Induced Amplitude Apodization (PIAA) Coronagraph

    NASA Technical Reports Server (NTRS)

    Kern, Brian; Guyon, Olivier; Give'on, Amir; Kuhnert, Andreas; Niessner, Albert

    2011-01-01

    We present high-contrast images from laboratory testing of a Phase Induced Amplitude Apodization (PIAA) coronagraph at NASA's High Contrast Imaging Testbed (HCIT). Using a deformable mirror and wavefront estimation and control algorithms, we create a 'dark hole' in the monochromatic point-spread function with an inner working angle of (2.05 f lambda/D), with a mean intensity 3.5x10(exp -8). We discuss the contributions to this floor, and the techniques being developed to improve it. We also present simulations that investigate the effect of Lyot stops of various sizes, and conclude that a Lyot stop is necessary for 10(exp -9) performance but that an annular postapodizer is not necessary.

  10. Test and Validation of the Mars Science Laboratory Robotic Arm

    NASA Technical Reports Server (NTRS)

    Robinson, M.; Collins, C.; Leger, P.; Kim, W.; Carsten, J.; Tompkins, V.; Trebi-Ollennu, A.; Florow, B.

    2013-01-01

    The Mars Science Laboratory Robotic Arm (RA) is a key component for achieving the primary scientific goals of the mission. The RA supports sample acquisition by precisely positioning a scoop above loose regolith or accurately preloading a percussive drill on Martian rocks or rover-mounted organic check materials. It assists sample processing by orienting a sample processing unit called CHIMRA through a series of gravity-relative orientations and sample delivery by positioning the sample portion door above an instrument inlet or the observation tray. In addition the RA facilitates contact science by accurately positioning the dust removal tool, Alpha Particle X-Ray Spectrometer (APXS) and the Mars Hand Lens Imager (MAHLI) relative to surface targets. In order to fulfill these seemingly disparate science objectives the RA must satisfy a variety of accuracy and performance requirements. This paper describes the necessary arm requirement specification and the test campaign to demonstrate these requirements were satisfied.

  11. [Laboratory tests and therapeutic strategies for the porphyrias].

    PubMed

    Poblete-Gutiérrez, P; Wiederholt, T; Merk, H F; Frank, J

    2006-06-01

    The porphyrias are a heterogeneous group of predominantly hereditary metabolic diseases resulting from a dysfunction of heme biosynthesis. Most of the porphyrias can manifest with a broad range of cutaneous symptoms on the sun-exposed areas of the body, whereas other variants reveal life-threatening acute neurological attacks. Further, mixed types of porphyrias exist. Besides the skin, other organs can be affected, such as the liver and the central nervous system. Therefore, interdisciplinary supervision of these patients is mandatory. In this review we will first present the clinical picture and diagnosis of the porphyrias, including the specific biochemical laboratory tests and a diagnostic algorithm. Thereafter, the current therapeutic concepts will be briefly addressed. Finally, we introduce the European Porphyria Initiative (EPI), an association of various European porphyria centers that is aiming at gathering the broad experience of internationally renowned porphyria experts for the development of European consensus guidelines for diagnosis and treatment of these metabolic disorders.

  12. Sandia National Laboratories' new high level acoustic test facility

    SciTech Connect

    Rogers, J. D.; Hendrick, D. M.

    1989-01-01

    A high intensity acoustic test facility has been designed and is under construction at Sandia National Laboratories in Albuquerque, NM. The chamber is designed to provide an acoustic environment of 154dB (re 20 {mu}Pa) overall sound pressure level over the bandwidth of 50 Hz to 10,000 Hz. The chamber has a volume of 16,000 cubic feet with interior dimensions of 21.6 ft {times} 24.6 ft {times} 30 ft. The construction of the chamber should be complete by the summer of 1990. This paper discusses the design goals and constraints of the facility. The construction characteristics are discussed in detail, as are the acoustic performance design characteristics. The authors hope that this work will help others in designing acoustic chambers. 12 refs., 6 figs.

  13. Confidence Intervals for Laboratory Sonic Boom Annoyance Tests

    NASA Technical Reports Server (NTRS)

    Rathsam, Jonathan; Christian, Andrew

    2016-01-01

    Commercial supersonic flight is currently forbidden over land because sonic booms have historically caused unacceptable annoyance levels in overflown communities. NASA is providing data and expertise to noise regulators as they consider relaxing the ban for future quiet supersonic aircraft. One deliverable NASA will provide is a predictive model for indoor annoyance to aid in setting an acceptable quiet sonic boom threshold. A laboratory study was conducted to determine how indoor vibrations caused by sonic booms affect annoyance judgments. The test method required finding the point of subjective equality (PSE) between sonic boom signals that cause vibrations and signals not causing vibrations played at various amplitudes. This presentation focuses on a few statistical techniques for estimating the interval around the PSE. The techniques examined are the Delta Method, Parametric and Nonparametric Bootstrapping, and Bayesian Posterior Estimation.

  14. Tests for oil/dispersant toxicity: In situ laboratory assays

    SciTech Connect

    Wright, D.A.; Coelho, G.M.; Aurand, D.V.

    1995-12-31

    As part of its readiness program in oil spill response, the Marine Pollution Control Unit (MPCU), Department of Transport, U.K. conducts annual field trials in the North Sea, approximately 30 nautical miles from the southeast coast of England. The trials take the form of controlled releases of crude oil or Medium Fuel/Gas Oil mix (MFO), with and without the application of Corexit 9527 dispersant. In 1994 and 1995 the authors conducted a series of in situ toxicity bioassays in association with these spills with included 48h LC50 tests for turbot (Scophthalmus maximus) and oyster (Crassostrea gigas) larvae, a 48 h oyster (C. gigas) embryonic development test and two full life-cycle assays using the copepods Acartia tonsa and Tisbe battagliai. Tests were also conducted in the Chesapeake Bay laboratory using estuarine species including the copepod Eurytemora affinis and the inland silverside Menidia beryllina. Here, the authors report on the results of these assays, together with 1996 in situ toxicity data resulting from Norwegian field trials in the northern North Sea.

  15. Laboratory tests of IEC DER object models for grid applications.

    SciTech Connect

    Blevins, John D.; Menicucci, David F.; Byrd, Thomas, Jr.; Gonzalez, Sigifredo; Ginn, Jerry W.; Ortiz-Moyet, Juan

    2007-02-01

    This report describes a Cooperative Research and Development Agreement (CRADA) between Salt River Project Agricultural Improvement and Power District (SRP) and Sandia National Laboratories to jointly develop advanced methods of controlling distributed energy resources (DERs) that may be located within SRP distribution systems. The controls must provide a standardized interface to allow plug-and-play capability and should allow utilities to take advantage of advanced capabilities of DERs to provide a value beyond offsetting load power. To do this, Sandia and SRP field-tested the IEC 61850-7-420 DER object model (OM) in a grid environment, with the goal of validating whether the model is robust enough to be used in common utility applications. The diesel generator OM tested was successfully used to accomplish basic genset control and monitoring. However, as presently constituted it does not enable plug-and-play functionality. Suggestions are made of aspects of the standard that need further development and testing. These problems are far from insurmountable and do not imply anything fundamentally unsound or unworkable in the standard.

  16. 76 FR 39110 - Medicare Program; Section 3113: The Treatment of Certain Complex Diagnostic Laboratory Tests...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-05

    ... HUMAN SERVICES Centers for Medicare & Medicaid Services Medicare Program; Section 3113: The Treatment of... participate in the Treatment of Certain Complex Diagnostic Laboratory Tests Demonstration. The Demonstration... Treatment of Certain Complex Diagnostic Laboratory Tests Demonstration. The authorizing legislation...

  17. Turbulent Aeroheating Testing of Mars Science Laboratory Entry Vehicle

    NASA Technical Reports Server (NTRS)

    Hollis, Brian R.; Collier, Arnold S.

    2008-01-01

    An experimental investigation of turbulent aeroheating on the Mars Science Laboratory entry vehicle heat shield has been conducted in the Arnold Engineering Development Center Hypervelocity Wind Tunnel No. 9. Testing was performed on a 6-in. (0.1524 m) diameter MSL model in pure N2 gas in the tunnel's Mach 8 and Mach 10 nozzles at free stream Reynolds numbers of 4.1 x 10(exp 6)/ft to 49 x 10(exp 6)/ft (1.3 x 10(exp 7)/m to 19 x 10(exp 6/ft) and 1.2 x 10(exp 6)/ft to 19 x 10(exp 6)/ft (0.39 x 10(exp 7)/m to 62 x 10(exp 7)/m), respectively. These conditions were sufficient to span the regime of boundary-layer flow from completely laminar to fully-developed turbulent flow over the entire forebody. A supporting aeroheating test was also conducted in the Langley Research Center 20-Inch Mach 6 Air Tunnel at free stream Reynolds number of 1 x 10(exp 6)/ft to 7 x 10(exp 6)/ft (0.36 x 10(exp 7)/m to 2.2 x 10(exp 7)/m) in order to help corroborate the Tunnel 9 results. A complementary computational fluid dynamics study was conducted in parallel to the wind tunnel testing. Laminar and turbulent predictions were generated for the wind tunnel test conditions and comparisons were performed with the data for the purpose of helping to define uncertainty margins on predictions for aeroheating environments during entry into the Martian atmosphere. Data from both wind tunnel tests and comparisons with the predictions are presented herein. It was concluded from these comparisons that for perfect-gas conditions, the computational tools could predict fully-laminar or fully-turbulent heating conditions to within 12% or better of the experimental data.

  18. 3. Exterior view of Components Test Laboratory (T27), looking southeast. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. Exterior view of Components Test Laboratory (T-27), looking southeast. The building wing on the left houses the equipment room, and that on the right houses Test Cell 8 (oxidizer) and the oxidizer storage pit or vault. - Air Force Plant PJKS, Systems Integration Laboratory, Components Test Laboratory, Waterton Canyon Road & Colorado Highway 121, Lakewood, Jefferson County, CO

  19. 2. Exterior view of Components Test Laboratory (T27), looking southeast. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Exterior view of Components Test Laboratory (T-27), looking southeast. The building wing on the left houses the equipment room and that on the right houses Test Cell 8 (oxidizer) and the oxidizer storage pit or vault. - Air Force Plant PJKS, Systems Integration Laboratory, Components Test Laboratory, Waterton Canyon Road & Colorado Highway 121, Lakewood, Jefferson County, CO

  20. 42 CFR 493.1361 - Condition: Laboratories performing PPM procedures; testing personnel.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...; testing personnel. 493.1361 Section 493.1361 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES... Personnel for Nonwaived Testing Laboratories Performing Provider-Performed Microscopy (ppm) Procedures § 493.1361 Condition: Laboratories performing PPM procedures; testing personnel. The laboratory must have...

  1. 42 CFR 493.1361 - Condition: Laboratories performing PPM procedures; testing personnel.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...; testing personnel. 493.1361 Section 493.1361 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES... Personnel for Nonwaived Testing Laboratories Performing Provider-Performed Microscopy (ppm) Procedures § 493.1361 Condition: Laboratories performing PPM procedures; testing personnel. The laboratory must have...

  2. Congenital Abnormalities

    MedlinePlus

    ... Listen Español Text Size Email Print Share Congenital Abnormalities Page Content Article Body About 3% to 4% ... of congenital abnormalities earlier. 5 Categories of Congenital Abnormalities Chromosome Abnormalities Chromosomes are structures that carry genetic ...

  3. NASA Glenn Research Center Acoustical Testing Laboratory: Five year retrospective

    NASA Astrophysics Data System (ADS)

    Cooper, Beth A.; Akers, James C.; Passe, Paul J.

    2005-09-01

    In the five years since the NASA Glenn Research Center Acoustical Testing Laboratory (ATL) opened its doors in September, 2000, it has developed a comprehensive array of services and products that support hearing conservation goals within NASA and industry. The ATL provides acoustic emission testing and noise control engineering services for a variety of specialized customers, particularly developers of equipment and science experiments manifested for NASA's manned space missions. The ATL aggressively supports the vision of a low-noise on-orbit environment, which facilitates mission success as well as crew health, safety, and comfort. In concert with these goals, the ATL also produces and distributes free educational resources and low-noise advocacy tools for hearing conservation education and awareness. Among these are two compact discs of auditory demonstrations (of phenomena in acoustics, hearing conservation, and communication), and presentations, software packages, and other educational materials for use by engineers, audiologists, and other hearing conservation stakeholders. This presentation will highlight ATL's construction, history, technical capabilities, and current projects and will feature demonstrations of some of the unique educational resource materials that are distributed by the ATL.

  4. Current Recommendations for Laboratory Testing and Use of Bone Turnover Markers in Management of Osteoporosis

    PubMed Central

    Lee, Jehoon

    2012-01-01

    Osteoporosis is a major health problem worldwide, and is projected to increase exponentially due to the aging of the population. The absolute fracture risk in individual subjects is calculated by the use of algorithms which include bone mineral density (BMD), age, gender, history of prior fracture and other risk factors. This review describes the laboratory investigations into osteoporosis which include serum calcium, phosphate, creatinine, alkaline phosphatase and 25-hydroxyvitamin D and, additionally in men, testosterone. Parathyroid hormone (PTH) is measured in patients with abnormal serum calcium to determine its cause. Other laboratory investigations such as thyroid function testing, screening for multiple myeloma, and screening for Cushing's syndrome, are performed if indicated. Measurement of bone turnover markers (BTMs) is currently not included in algorithms for fracture risk calculations due to the lack of data. However, BTMs may be useful for monitoring osteoporosis treatment. Further studies of the reference BTMs serum carboxy terminal telopeptide of collagen type I (s-CTX) and serum procollagen type I N-terminal propeptide (s-PINP) in fracture risk prediction and in monitoring various treatments for osteoporosis may help expedite their inclusion in routine clinical practice. PMID:22389876

  5. Transportable Heavy Duty Emissions Testing Laboratory and Research Program

    SciTech Connect

    David Lyons

    2008-03-31

    The objective of this program was to quantify the emissions from heavy-duty vehicles operating on alternative fuels or advanced fuel blends, often with novel engine technology or aftertreatment. In the first year of the program West Virginia University (WVU) researchers determined that a transportable chassis dynamometer emissions measurement approach was required so that fleets of trucks and buses did not need to be ferried across the nation to a fixed facility. A Transportable Heavy-Duty Vehicle Emissions Testing Laboratory (Translab) was designed, constructed and verified. This laboratory consisted of a chassis dynamometer semi-trailer and an analytic trailer housing a full scale exhaust dilution tunnel and sampling system which mimicked closely the system described in the Code of Federal Regulations for engine certification. The Translab was first used to quantify emissions from natural gas and methanol fueled transit buses, and a second Translab unit was constructed to satisfy research demand. Subsequent emissions measurement was performed on trucks and buses using ethanol, Fischer-Tropsch fuel, and biodiesel. A medium-duty chassis dynamometer was also designed and constructed to facilitate research on delivery vehicles in the 10,000 to 20,000lb range. The Translab participated in major programs to evaluate low-sulfur diesel in conjunction with passively regenerating exhaust particulate filtration technology, and substantial reductions in particulate matter were recorded. The researchers also participated in programs to evaluate emissions from advanced natural gas engines with closed loop feedback control. These natural gas engines showed substantially reduced levels of oxides of nitrogen. For all of the trucks and buses characterized, the levels of carbon monoxide, oxides of nitrogen, hydrocarbons, carbon dioxide and particulate matter were quantified, and in many cases non-regulated species such as aldehydes were also sampled. Particle size was also

  6. Response of shallow geothermal energy pile from laboratory model tests

    NASA Astrophysics Data System (ADS)

    Marto, A.; Amaludin, A.

    2015-09-01

    In shallow geothermal energy pile systems, the thermal loads from the pile, transferred and stored in the soil will cause thermally induced settlement. This factor must be considered in the geotechnical design process to avoid unexpected hazards. Series of laboratory model tests were carried out to study the behaviour of energy piles installed in kaolin soil, subjected to thermal loads and a combination of axial and thermal loads (henceforth known as thermo-axial loads). Six tests which included two thermal load tests (35°C and 40°C) and four thermo-axial load tests (100 N and 200 N, combined with 35°C and 40°C thermal loads) were conducted. To simulate the behaviour of geothermal energy piles during its operation, the thermo-axial tests were carried out by applying an axial load to the model pile head, and a subsequent application of thermal load. The model soil was compacted at 90% maximum dry density and had an undrained shear strength of 37 kPa, thus classified as having a firm soil consistency. The behaviour of model pile, having the ultimate load capacity of 460 N, was monitored using a linear variable displacement transducer, load cell and wire thermocouple, to measure the pile head settlement, applied axial load and model pile temperature. The acquired data from this study was used to define the thermo-axial response characteristics of the energy pile model. In this study, the limiting settlement was defined as 10% of the model pile diameter. For thermal load tests, higher thermal loads induced higher values of thermal settlement. At 40°C thermal load an irreversible settlement was observed after the heating and cooling cycle was applied to the model pile. Meanwhile, the pile response to thermo-axial loads were attributed to soil consistency and the magnitude of both the axial and thermal loads applied to the pile. The higher the thermoaxial loads, the higher the settlements occurred. A slight hazard on the model pile was detected, since the settlement

  7. 9 CFR 54.11 - Approval of laboratories to run official scrapie tests and official genotype tests.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Approval of laboratories to run official scrapie tests and official genotype tests. 54.11 Section 54.11 Animals and Animal Products ANIMAL... laboratories to run official scrapie tests and official genotype tests. (a) State, Federal, and...

  8. 7 CFR 3300.91 - List of approved testing stations, approved testing laboratories, and fees for certificates.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... CARRIAGE OF PERISHABLE FOODSTUFFS AND ON THE SPECIAL EQUIPMENT TO BE USED FOR SUCH CARRIAGE (ATP... testing stations, approved testing laboratories, and fees for certificates. A current list of U.S. ATP testing stations, U.S. ATP testing laboratories, and fees for issuance of U.S. ATP certificates may...

  9. 9 CFR 54.11 - Approval of laboratories to run official scrapie tests and official genotype tests.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Approval of laboratories to run official scrapie tests and official genotype tests. 54.11 Section 54.11 Animals and Animal Products ANIMAL... laboratories to run official scrapie tests and official genotype tests. (a) State, Federal, and...

  10. 9 CFR 54.11 - Approval of laboratories to run official scrapie tests and official genotype tests.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Approval of laboratories to run official scrapie tests and official genotype tests. 54.11 Section 54.11 Animals and Animal Products ANIMAL... laboratories to run official scrapie tests and official genotype tests. (a) State, Federal, and...

  11. 49 CFR 40.85 - What drugs do laboratories test for?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... test. You must not test “DOT specimens” for any other drugs. (a) Marijuana metabolites. (b) Cocaine... 49 Transportation 1 2011-10-01 2011-10-01 false What drugs do laboratories test for? 40.85 Section... WORKPLACE DRUG AND ALCOHOL TESTING PROGRAMS Drug Testing Laboratories § 40.85 What drugs do...

  12. 49 CFR 40.85 - What drugs do laboratories test for?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... test. You must not test “DOT specimens” for any other drugs. (a) Marijuana metabolites. (b) Cocaine... 49 Transportation 1 2010-10-01 2010-10-01 false What drugs do laboratories test for? 40.85 Section... WORKPLACE DRUG AND ALCOHOL TESTING PROGRAMS Drug Testing Laboratories § 40.85 What drugs do...

  13. Internship at NASA Kennedy Space Center's Cryogenic Test laboratory

    NASA Technical Reports Server (NTRS)

    Holland, Katherine

    2013-01-01

    NASA's Kennedy Space Center (KSC) is known for hosting all of the United States manned rocket launches as well as many unmanned launches at low inclinations. Even though the Space Shuttle recently retired, they are continuing to support unmanned launches and modifying manned launch facilities. Before a rocket can be launched, it has to go through months of preparation, called processing. Pieces of a rocket and its payload may come in from anywhere in the nation or even the world. The facilities all around the center help integrate the rocket and prepare it for launch. As NASA prepares for the Space Launch System, a rocket designed to take astronauts beyond Low Earth Orbit throughout the solar system, technology development is crucial for enhancing launch capabilities at the KSC. The Cryogenics Test Laboratory at Kennedy Space Center greatly contributes to cryogenic research and technology development. The engineers and technicians that work there come up with new ways to efficiently store and transfer liquid cryogens. NASA has a great need for this research and technology development as it deals with cryogenic liquid hydrogen and liquid oxygen for rocket fuel, as well as long term space flight applications. Additionally, in this new era of space exploration, the Cryogenics Test Laboratory works with the commercial sector. One technology development project is the Liquid Hydrogen (LH2) Ground Operations Demonstration Unit (GODU). LH2 GODU intends to demonstrate increased efficiency in storing and transferring liquid hydrogen during processing, loading, launch and spaceflight of a spacecraft. During the Shuttle Program, only 55% of hydrogen purchased was used by the Space Shuttle Main Engines. GODU's goal is to demonstrate that this percentage can be increased to 75%. Figure 2 shows the GODU layout when I concluded my internship. The site will include a 33,000 gallon hydrogen tank (shown in cyan) with a heat exchanger inside the hydrogen tank attached to a

  14. Results from laboratory and field testing of nitrate measuring spectrophotometers

    USGS Publications Warehouse

    Snazelle, Teri T.

    2015-01-01

    In Phase II, the analyzers were deployed in field conditions at three diferent USGS sites. The measured nitrate concentrations were compared to discrete (reference) samples analyzed by the Direct UV method on a Shimadzu UV1800 bench top spectrophotometer, and by the National Environmental Methods Index (NEMI) method I-2548-11 at the USGS National Water Quality Laboratory. The first deployment at USGS site 0249620 on the East Pearl River in Hancock County, Mississippi, tested the ability of the TriOs ProPs (10-mm path length), Hach NITRATAX (5 mm), Satlantic SUNA (10 mm), and the S::CAN Spectro::lyser (5 mm) to accurately measure low-level (less than 2 mg-N/L) nitrate concentrations while observing the effect turbidity and colored dissolved organic matter (CDOM) would have on the analyzers' measurements. The second deployment at USGS site 01389005 Passaic River below Pompton River at Two Bridges, New Jersey, tested the analyzer's accuracy in mid-level (2-8 mg-N/L) nitrate concentrations. This site provided the means to test the analyzers' performance in two distinct matrices—the Passaic and the Pompton Rivers. In this deployment, three instruments tested in Phase I (TriOS, Hach, and SUNA) were deployed with the S::CAN Spectro::lyser (35 mm) already placed by the New Jersey Water Science Center (WSC). The third deployment at USGS site 05579610 Kickapoo Creek at 2100E Road near Bloomington, Illinois, tested the ability of the analyzers to measure high nitrate concentrations (greater than 8 mg-N/L) in turbid waters. For Kickapoo Creek, the HIF provided the TriOS (10 mm) and S::CAN (5 mm) from Phase I, and a SUNA V2 (5 mm) to be deployed adjacent to the Illinois WSC-owned Hach (2 mm). A total of 40 discrete samples were collected from the three deployment sites and analyzed. The nitrate concentration of the samples ranged from 0.3–22.2 mg-N/L. The average absolute difference between the TriOS measurements and discrete samples was 0.46 mg-N/L. For the combined data

  15. Capability of the Gas Analysis and Testing Laboratory at the NASA Johnson Space Center

    NASA Technical Reports Server (NTRS)

    Broerman, Craig; Jimenez, Javier; Sweterlitsch, Jeff

    2012-01-01

    The Gas Analysis and Testing Laboratory is an integral part of the testing performed at the NASA Johnson Space Center. The Gas Analysis and Testing Laboratory is a high performance laboratory providing real time analytical instruments to support manned and unmanned testing. The lab utilizes precision gas chromatographs, gas analyzers and spectrophotometers to support the technology development programs within the NASA community. The Gas Analysis and Testing Laboratory works with a wide variety of customers and provides engineering support for user-specified applications in compressed gas, chemical analysis, general and research laboratory.

  16. Capability of the Gas Analysis and Testing Laboratory at the NASA Johnson Space Center

    NASA Technical Reports Server (NTRS)

    Broerman, Craig; Jimenez, Javier; Sweterlitsch, Jeff

    2011-01-01

    The Gas Analysis and Testing Laboratory is an integral part of the testing performed at the NASA Johnson Space Center. The Gas Analysis and Testing Laboratory is a high performance laboratory providing real time analytical instruments to support manned and unmanned testing. The lab utilizes precision gas chromatographs, gas analyzers and spectrophotometers to support the technology development programs within the NASA community. The Gas Analysis and Testing Laboratory works with a wide variety of customers and provides engineering support for user-specified applications in compressed gas, chemical analysis, general and research laboratory

  17. Weapons Evaluation Test Laboratory at Pantex: Testing and data handling capabilities of Sandia National Laboratories at the Pantex Plant, Amarillo, Texas

    SciTech Connect

    Peters, W.R.

    1993-08-01

    The Weapons Evaluation Test Laboratory (WETL), operated by Sandia Laboratories at the Pantex Plant in Amarillo, Texas, is engaged primarily in the testing of weapon systems in the stockpile or of newly produced weapon systems for the Sandia Surety Assessment Center. However, the WETL`s unique testing equipment and data-handling facilities are frequently used to serve other organizations. Service to other organizations includes performing special tests on weapon components, subassemblies, and systems for purposes such as basic development and specific problem investigation. The WETL staff also sends equipment to other laboratories for specific tests that cannot be performed at Pantex. For example, we modified and sent equipment to Brookhaven National Laboratory for testing with their Neutral Particle Beam. WETL supplied the engineering expertise to accomplish the needed modifications to the equipment and the technicians to help perform many special tests at Brookhaven. A variety of testing is possible within the WETL, including: Accelerometer, decelerometer, and G-switch g-level/closure testing; Neutron generator performance testing; weapon systems developmental tests; weapon system component testing; weapon system failure-mode-duplication tests; simultaneity measurements; environmental extreme testing; parachute deployment testing; permissive action link (PAL) testing and trajectory-sensing signal generator (TSSG) testing. WETL`s existing equipment configurations do not restrict the testing performed at the WETL. Equipment and facilities are adapted to specific requirements. The WETL`s facilities can often eliminate the need to build or acquire new test equipment, thereby saving time and expense.

  18. Multi-Sensor Testing for Automated Rendezvous and Docking Sensor Testing at the Flight Robotics Laboratory

    NASA Technical Reports Server (NTRS)

    Brewster, L.; Johnston, A.; Howard, R.; Mitchell, J.; Cryan, S.

    2007-01-01

    The Exploration Systems Architecture defines missions that require rendezvous, proximity operations, and docking (RPOD) of two spacecraft both in Low Earth Orbit (LEO) and in Low Lunar Orbit (LLO). Uncrewed spacecraft must perform automated and/or autonomous rendezvous, proximity operations and docking operations (commonly known as AR&D). The crewed missions may also perform rendezvous and docking operations and may require different levels of automation and/or autonomy, and must provide the crew with relative navigation information for manual piloting. The capabilities of the RPOD sensors are critical to the success of the Exploration Program. NASA has the responsibility to determine whether the Crew Exploration Vehicle (CEV) contractor proposed relative navigation sensor suite will meet the requirements. The relatively low technology readiness level of AR&D relative navigation sensors has been carried as one of the CEV Project's top risks. The AR&D Sensor Technology Project seeks to reduce the risk by the testing and analysis of selected relative navigation sensor technologies through hardware-in-the-loop testing and simulation. These activities will provide the CEV Project information to assess the relative navigation sensors maturity as well as demonstrate test methods and capabilities. The first year of this project focused on a series of"pathfinder" testing tasks to develop the test plans, test facility requirements, trajectories, math model architecture, simulation platform, and processes that will be used to evaluate the Contractor-proposed sensors. Four candidate sensors were used in the first phase of the testing. The second phase of testing used four sensors simultaneously: two Marshall Space Flight Center (MSFC) Advanced Video Guidance Sensors (AVGS), a laser-based video sensor that uses retroreflectors attached to the target vehicle, and two commercial laser range finders. The multi-sensor testing was conducted at MSFC's Flight Robotics Laboratory (FRL

  19. Laboratory testing of candidate robotic applications for space

    NASA Technical Reports Server (NTRS)

    Purves, R. B.

    1987-01-01

    Robots have potential for increasing the value of man's presence in space. Some categories with potential benefit are: (1) performing extravehicular tasks like satellite and station servicing, (2) supporting the science mission of the station by manipulating experiment tasks, and (3) performing intravehicular activities which would be boring, tedious, exacting, or otherwise unpleasant for astronauts. An important issue in space robotics is selection of an appropriate level of autonomy. In broad terms three levels of autonomy can be defined: (1) teleoperated - an operator explicitly controls robot movement; (2) telerobotic - an operator controls the robot directly, but by high-level commands, without, for example, detailed control of trajectories; and (3) autonomous - an operator supplies a single high-level command, the robot does all necessary task sequencing and planning to satisfy the command. Researchers chose three projects for their exploration of technology and implementation issues in space robots, one each of the three application areas, each with a different level of autonomy. The projects were: (1) satellite servicing - teleoperated; (2) laboratory assistant - telerobotic; and (3) on-orbit inventory manager - autonomous. These projects are described and some results of testing are summarized.

  20. Laboratory testing of cement grouting of fractures in welded tuff

    SciTech Connect

    Sharpe, C.J.; Daemen, J.J.

    1991-03-01

    Fractures in the rock mass surrounding a repository and its shafts, access drifts, emplacement rooms and holes, and exploratory or in-situ testing holes, may provide preferential flowpaths for the flow of groundwater or air, potentially containing radionuclides. Such cracks may have to be sealed. The likelihood that extensive or at least local grouting will be required as part of repository sealing has been noted in numerous publications addressing high level waste repository closing. The objective of this work is to determine the effectiveness of fracture sealing (grouting) in welded tuff. Experimental work includes measurement of intact and fracture permeability under various normal stresses and injection pressures. Grout is injected into the fractures. The effectiveness of grouting is evaluated in terms of grout penetration and permeability reduction, compared prior to and after grouting. Analysis of the results include the effect of normal stress, injection pressure, fracture roughness, grout rheology, grout bonding, and the radial extent of grout penetration. Laboratory experiments have been performed on seventeen tuff cylinders with three types of fractures: (1) tension induced cracks, (2) natural fractures, and (3) sawcuts. Prior to grouting, the hydraulic conductivity of the intact rock and of the fractures is measured under a range of normal stresses. The surface topography of the fracture is mapped, and the results are used to determine aperture distributions across the fractures. 72 refs., 76 figs., 25 tabs.

  1. HPV is detectable in virtually all abnormal cervical cytology samples after reinvestigation of HPV negatives with multiple alternative PCR tests.

    PubMed

    Evans, Mark Francis; Adamson, Christine Stewart-Crawford; Schned, Laura Meredith; St John, Timothy Louis; Leiman, Gladwyn; Ashikaga, Takamaru; Cooper, Kumarasen

    2010-09-01

    The demonstration of human papillomavirus (HPV) in 99.7% of cervical carcinoma surgical specimens from around the world required investigations by multiple alternative polymerase chain reaction (PCR) assays. A similar approach may therefore be necessary to best characterize HPV prevalence and genotype distribution among cervical cytology samples. In an earlier study, 752 of 799 (94.1%) abnormal and 82 of 300 (27.3%) normal cytology specimens tested HPV positive after PCR using GP5+/6+primers. This study has reinvestigated the "HPV negative" abnormal samples (20 atypical squamous cells of undetermined significance, 5 low-grade squamous intraepithelial lesion, 14 atypical squamous cells, cannot exclude HSIL, 6 high-grade squamous intraepithelial lesion) and an age-matched cohort of "HPV negative" normal (negative for an intraepithelial lesion or malignancy) samples by PCR using PGMY09/11, FAP59/64, and LCR-E7 primers. PGMY09/11-GP5+/6+ nested PCR was performed on samples that were HPV negative by PGMY09/11 PCR. After the first 3 assays, HPV was detected in 41 of 45 (91.1%) abnormal and in 10 of 47 (21.3%) normal samples (P<0.0001). Eighteen HPV genotypes were detected and in some samples the genotype that was identified differed between the tests. The nondetection of common HPV genotypes (eg, HPVs 6, 11, 16, and 18) was notable. High-grade histopathology was found for 2 patients with HPV52-positive cytopathology. Combined with our earlier study, HPV (40 different genotypes) is shown in 99.5% of abnormal samples (99.8% inclusive of the nested PCR data). These findings show that HPV genotype and prevalence estimates are dependent on the method(s) of detection and indicate that suboptimal analytical sensitivity for one or more of the less common high-risk HPV genotypes could lead to impaired clinical sensitivity. HPV may be causal in almost every instance of abnormal cervical cytology; however, passenger HPV that is incidental to an abnormality may also have been

  2. Evaluation of distal symmetric polyneuropathy: the role of laboratory and genetic testing (an evidence-based review).

    PubMed

    England, J D; Gronseth, G S; Franklin, G; Carter, G T; Kinsella, L J; Cohen, J A; Asbury, A K; Szigeti, K; Lupski, J R; Latov, N; Lewis, R A; Low, P A; Fisher, M A; Herrmann, D; Howard, J F; Lauria, G; Miller, R G; Polydefkis, M; Sumner, A J

    2009-01-01

    Distal symmetric polyneuropathy (DSP) is the most common variety of neuropathy. Since the evaluation of this disorder is not standardized, the available literature was reviewed to provide evidence-based guidelines regarding the role of laboratory and genetic tests for the assessment of DSP. A literature review using MEDLINE, EMBASE, Science Citation Index, and Current Contents was performed to identify the best evidence regarding the evaluation of polyneuropathy published between 1980 and March 2007. Articles were classified according to a four-tiered level of evidence scheme and recommendations were based on the level of evidence. (1) Screening laboratory tests may be considered for all patients with polyneuropathy (Level C). Those tests that provide the highest yield of abnormality are blood glucose, serum B(12) with metabolites (methylmalonic acid with or without homocysteine), and serum protein immunofixation electrophoresis (Level C). If there is no definite evidence of diabetes mellitus by routine testing of blood glucose, testing for impaired glucose tolerance may be considered in distal symmetric sensory polyneuropathy (Level C). (2) Genetic testing is established as useful for the accurate diagnosis and classification of hereditary neuropathies (Level A). Genetic testing may be considered in patients with cryptogenic polyneuropathy who exhibit a hereditary neuropathy phenotype (Level C). Initial genetic testing should be guided by the clinical phenotype, inheritance pattern, and electrodiagnostic (EDX) features and should focus on the most common abnormalities, which are CMT1A duplication/HNPP deletion, Cx32 (GJB1), and MFN2 mutation screening. There is insufficient evidence to determine the usefulness of routine genetic testing in patients with cryptogenic polyneuropathy who do not exhibit a hereditary neuropathy phenotype (Level U).

  3. Test plan: Laboratory-scale testing of the first core sample from Tank 102-AZ

    SciTech Connect

    Morrey, E.V.

    1996-03-01

    The overall objectives of the Radioactive Process/Product Laboratory Testing (RPPLT), WBS 1.2.2.05.05, are to confirm that simulated HWVP feed and glass are representative of actual radioactive HWVP feed and glass and to provide radioactive leaching and glass composition data to WFQ. This study will provide data from one additional NCAW core sample (102-AZ Core 1) for these purposes.

  4. Abnormalities of the testes and epididymis in bucks and rams slaughtered at Debre Zeit abattoir, Ethiopia.

    PubMed

    Regassa, F; Terefe, F; Bekana, M

    2003-12-01

    A study was conducted at Debre Zeit export abattoir on 404 bucks belonging to four breeds and 167 rams of two breeds. The animals were selected from the slaughter flock using stratified sampling based on breed. Ante-mortem and post-mortem examinations were carried out after each animal was carefully identified. Various genital abnormalities were observed, among which testicular atrophy and epididymitis were the predominant genital problems in both bucks and rams. The prevalence of cryptorchidism was higher (p<0.05) in bucks than in rams, while epididymitis (p<0.05), sperm granuloma (p<0.01) and epididymal cysts (p<0.05) were more frequent in rams. In bucks, none of these abnormalities was significantly associated with age (p>0.05). However, testicular atrophy (p<0.01), epididymitis (p<0.01) and haemorrhagic lesions (p<0.05) were associated with breed, the prevalence being higher in Woito-Guji and Boran bucks than in the Arsi-Bale and Afar breeds. In rams, age affected (p<0.05) the incidence of testicular atrophy, epididymitis and sperm granulomas. Epididymitis, sperm granuloma and epididymal cysts were more frequent (p<0.01) in Adal rams than in Black Head Somalis.

  5. 7. Exterior view of Components Test Laboratory (T27), looking south. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. Exterior view of Components Test Laboratory (T-27), looking south. The wing in the immediate foreground houses the equipment room. - Air Force Plant PJKS, Systems Integration Laboratory, Components Test Laboratory, Waterton Canyon Road & Colorado Highway 121, Lakewood, Jefferson County, CO

  6. 10 CFR 26.153 - Using certified laboratories for testing urine specimens.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    .... 26.153 Section 26.153 Energy NUCLEAR REGULATORY COMMISSION FITNESS FOR DUTY PROGRAMS Laboratories... initial and confirmatory tests for specimen validity and for each drug and drug metabolite for which the... laboratory; (3) The laboratory shall maintain test records in confidence, consistent with the requirements...

  7. 33 CFR 209.340 - Laboratory investigations and materials testing.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... laboratory facilities capable of performing such work are not available, or because of location or for other reasons it is clearly impractical to utilize such private commerical laboratory services. The requesting entity must further certify that such services cannot be procured reasonably and expeditiously...

  8. 33 CFR 209.340 - Laboratory investigations and materials testing.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... laboratory facilities capable of performing such work are not available, or because of location or for other reasons it is clearly impractical to utilize such private commerical laboratory services. The requesting entity must further certify that such services cannot be procured reasonably and expeditiously...

  9. Recommended procedures for performance testing of radiobioassay laboratories: Volume 2, In vitro samples

    SciTech Connect

    Fenrick, H.W.; MacLellan, J.A.

    1988-11-01

    Draft American National Standards Institute (ANSI) Standard N13.30 (Performance Criteria for Radiobioassay) was developed for the US Department of Energy and the US Nuclear Regulatory Commission to help ensure that bioassay laboratories provide accurate and consistent results. The draft standard specifies the criteria for defining the procedures necessary to establish a bioassay performance-testing laboratory and program. The bioassay testing laboratory will conduct tests to evaluate the performance of service laboratories. Pacific Northwest Laboratory helped develop testing procedures as part of an effort to evaluate the performance criteria by testing the existing measurement capabilities of various bioassay laboratories. This report recommends guidelines for the preparation, handling, storage, distribution, shipping, and documentation of in vitro test samples (artificial urine and fecal matter) for indirect bioassay. The data base and recommended records system for documenting radiobioassay performance at the service laboratories are also presented. 8 refs., 3 tabs.

  10. 20 CFR 416.919k - Purchase of medical examinations, laboratory tests, and other services.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ..., laboratory tests, and other services. We may purchase medical examinations, including psychiatric and psychological examinations, X-rays and laboratory tests (including specialized tests, such as pulmonary function... tests, and other services. 416.919k Section 416.919k Employees' Benefits SOCIAL SECURITY...

  11. 20 CFR 404.1519k - Purchase of medical examinations, laboratory tests, and other services.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ..., laboratory tests, and other services. We may purchase medical examinations, including psychiatric and psychological examinations, X-rays and laboratory tests (including specialized tests, such as pulmonary function... tests, and other services. 404.1519k Section 404.1519k Employees' Benefits SOCIAL...

  12. 20 CFR 404.1519k - Purchase of medical examinations, laboratory tests, and other services.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ..., laboratory tests, and other services. We may purchase medical examinations, including psychiatric and psychological examinations, X-rays and laboratory tests (including specialized tests, such as pulmonary function... tests, and other services. 404.1519k Section 404.1519k Employees' Benefits SOCIAL...

  13. 20 CFR 416.919k - Purchase of medical examinations, laboratory tests, and other services.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ..., laboratory tests, and other services. We may purchase medical examinations, including psychiatric and psychological examinations, X-rays and laboratory tests (including specialized tests, such as pulmonary function... tests, and other services. 416.919k Section 416.919k Employees' Benefits SOCIAL SECURITY...

  14. 20 CFR 416.919k - Purchase of medical examinations, laboratory tests, and other services.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ..., laboratory tests, and other services. We may purchase medical examinations, including psychiatric and psychological examinations, X-rays and laboratory tests (including specialized tests, such as pulmonary function... tests, and other services. 416.919k Section 416.919k Employees' Benefits SOCIAL SECURITY...

  15. 20 CFR 416.919k - Purchase of medical examinations, laboratory tests, and other services.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ..., laboratory tests, and other services. We may purchase medical examinations, including psychiatric and psychological examinations, X-rays and laboratory tests (including specialized tests, such as pulmonary function... tests, and other services. 416.919k Section 416.919k Employees' Benefits SOCIAL SECURITY...

  16. 20 CFR 404.1519k - Purchase of medical examinations, laboratory tests, and other services.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ..., laboratory tests, and other services. We may purchase medical examinations, including psychiatric and psychological examinations, X-rays and laboratory tests (including specialized tests, such as pulmonary function... tests, and other services. 404.1519k Section 404.1519k Employees' Benefits SOCIAL...

  17. 20 CFR 404.1519k - Purchase of medical examinations, laboratory tests, and other services.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ..., laboratory tests, and other services. We may purchase medical examinations, including psychiatric and psychological examinations, X-rays and laboratory tests (including specialized tests, such as pulmonary function... tests, and other services. 404.1519k Section 404.1519k Employees' Benefits SOCIAL...

  18. 20 CFR 404.1519k - Purchase of medical examinations, laboratory tests, and other services.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ..., laboratory tests, and other services. We may purchase medical examinations, including psychiatric and psychological examinations, X-rays and laboratory tests (including specialized tests, such as pulmonary function... tests, and other services. 404.1519k Section 404.1519k Employees' Benefits SOCIAL...

  19. 20 CFR 416.919k - Purchase of medical examinations, laboratory tests, and other services.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ..., laboratory tests, and other services. We may purchase medical examinations, including psychiatric and psychological examinations, X-rays and laboratory tests (including specialized tests, such as pulmonary function... tests, and other services. 416.919k Section 416.919k Employees' Benefits SOCIAL SECURITY...

  20. 77 FR 126 - Current List of Laboratories and Instrumented Initial Testing Facilities Which Meet Minimum...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-03

    ... HUMAN SERVICES Substance Abuse and Mental Health Services Administration Current List of Laboratories... Testing for Federal Agencies AGENCY: Substance Abuse and Mental Health Services Administration, HHS... Program for Substance Abuse (LAPSA) effective May 12, 1998. Laboratories certified through that...

  1. 78 FR 7795 - Current List of Laboratories and Instrumented Initial Testing Facilities Which Meet Minimum...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-04

    ... HUMAN SERVICES Substance Abuse and Mental Health Services Administration Current List of Laboratories... Testing for Federal Agencies AGENCY: Substance Abuse and Mental Health Services Administration, HHS... Standards Council of Canada (SCC) voted to end its Laboratory Accreditation Program for Substance...

  2. 78 FR 59946 - Current List of Laboratories and Instrumented Initial Testing Facilities Which Meet Minimum...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-30

    ... HUMAN SERVICES Substance Abuse and Mental Health Services Administration Current List of Laboratories... Testing for Federal Agencies AGENCY: Substance Abuse and Mental Health Services Administration, HHS... Accreditation Program for Substance Abuse (LAPSA) effective May 12, 1998. Laboratories certified through...

  3. 77 FR 69642 - Current List of Laboratories and Instrumented Initial Testing Facilities Which Meet Minimum...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-20

    ... HUMAN SERVICES Substance Abuse and Mental Health Services Administration Current List of Laboratories... Testing for Federal Agencies AGENCY: Substance Abuse and Mental Health Services Administration, HHS... its Laboratory Accreditation Program for Substance Abuse (LAPSA) effective May 12, 1998....

  4. 78 FR 72684 - Current List of Laboratories and Instrumented Initial Testing Facilities Which Meet Minimum...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-03

    ... HUMAN SERVICES Substance Abuse and Mental Health Services Administration Current List of Laboratories... Testing for Federal Agencies AGENCY: Substance Abuse and Mental Health Services Administration, HHS... its Laboratory Accreditation Program for Substance Abuse (LAPSA) effective May 12, 1998....

  5. 76 FR 11802 - Current List of Laboratories and Instrumented Initial Testing Facilities Which Meet Minimum...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-03

    ... HUMAN SERVICES Substance Abuse and Mental Health Services Administration Current List of Laboratories... Testing for Federal Agencies AGENCY: Substance Abuse and Mental Health Services Administration, HHS... its Laboratory Accreditation Program for Substance Abuse (LAPSA) effective May 12, 1998....

  6. 77 FR 32653 - Current List of Laboratories and Instrumented Initial Testing Facilities Which Meet Minimum...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-01

    ... HUMAN SERVICES Substance Abuse and Mental Health Services Administration Current List of Laboratories... Testing for Federal Agencies AGENCY: Substance Abuse and Mental Health Services Administration, HHS... Council of Canada (SCC) voted to end its Laboratory Accreditation Program for Substance Abuse...

  7. Standards for thyroid laboratory testing, and cognitive functions after menopause

    PubMed Central

    Bejga, Przemysław; Witczak, Mariusz; Łyszcz, Robert; Makara-Studzinska, Marta

    2014-01-01

    Introduction The aim of the study is to analyze the relationship between normative and non-normative thyroid tests (TSH, TT4, TT3, FT3, FT4, anti-TPO, anti-Tg, AB-TSHR) and the level of cognitive functions in postmenopausal women. Material and methods The study group consisted of 383 women from south-eastern Poland, aged 50-65 years. The cognitive functions were evaluated using a diagnostic instrument – Central Nervous System – Vital Signs (CNS-VS). Blood was collected for determination of the following parameters: TSH, TT4, TT3, FT3, FT4, anti-TPO, anti-Tg, AB-TSHR. Results There were significant differences in NCI, executive functions, psychomotor speed, reaction time, complex attention and cognitive flexibility, depending on the normative and non-normative level of TSH. Women whose level of FT3 was at the lower limit of the normal range obtained poorer results in psychomotor speed, while subjects with levels of FT4 below the standard achieved significantly lower scores for this function. The relationship between NCI and cognitive functions, and the normative and non-normative anti-TPO results, showed significant differences in verbal memory, visual memory, processing speed and reaction time. The level of AB-TSHR reported as normal or above the norm significantly differentiated from the results of NCI, processing speed, executive functions, psychomotor speed, complex attention and cognitive flexibility. Conclusions Concentrations of laboratory parameters assessing the thyroid function located within the upper limits of the normal range showed a different relationship with the cognitive performance than concentrations located within the lower limits of the standard. PMID:26327860

  8. Settling velocity of marine microplastic particles: laboratory tests

    NASA Astrophysics Data System (ADS)

    Isachenko, Igor; Khatmullina, Lilia; Chubarenko, Irina; Stepanova, Natalia

    2016-04-01

    An assessment of the settling velocity of different classes of microplastic particles (< 5 mm) is crucial for the prediction of their transport and fate. The Reynolds numbers for the settling microplastic particles is usually outside the Stokes range (Re << 1), but still far from fully developed turbulent flow (Re >105). Even for such transitional regime, the settling velocity of the particles that could be treated as more or less smooth spheres can be predicted with high accuracy by relationships available in publications. This is not the case for the non-spherical particles like fibres or flakes. There are quite a large number of quasi-theoretical or semi-empirical approaches that take into account the shape and roughness of the particles, usually in the applications to transport of natural sediments. Some engineering formulas for the settling velocity are also developed which have simpler structure along with high degree of accuracy on the set of experimental data. For marine microplastic particles, the absence of relationship between the settling velocity and the properties of the particle requires testing on the samples of marine microplastics. Besides small fragments of rigid plastic (granules, microbeads), there are also fibres and thin plastic sheets (flakes) with some degree of flexibility. The applicability of available formulae to thin and/or flexible plastic particles again requires verification by experiments. The set of laboratory experiments on settling of microplastic particles of various shapes and excess densities in homogeneous water is reported. The particles were collected in water column, bottom sediments and on the beaches of the South-Eastern Baltic. The experiments demonstrate not just different regimes of motion but different manner of the sinking of spheres, flakes and fibres. The very definition of the "settling velocity" has a specific meaning for every kind of a particle shape. The results of test measurements are compared with

  9. Results of Laboratory Testing of Advanced Power Strips: Preprint

    SciTech Connect

    Earle, L.; Sparn, B.

    2012-08-01

    This paper describes the results of a laboratory investigation to evaluate the technical performance of advanced power strip (APS) devices when subjected to a range of home entertainment center and home office usage scenarios.

  10. Liver Function Test Abnormalities in Depressed Patients Treated with Antidepressants: A Real-World Systematic Observational Study in Psychiatric Settings

    PubMed Central

    Verstuyft, Céline; Corruble, Emmanuelle; Perlemuter, Gabriel; Colle, Romain

    2016-01-01

    Background Concerning the risk of antidepressant induced liver injury, it is not clear whether psychiatrists perform a liver function test (LFT) and whether an increase in aminotransferase levels should contraindicate antidepressant treatment. Aim To evaluate LFT availability, the prevalence of LFT abnormalities and the probable cause of an altered LFT in patients with a major depressive episode (MDE) requiring an antidepressant drug. Methods We studied LFT evaluation in a real world psychiatric setting, in a sample of 321 consecutive patients with a current major depressive episode (MDE) requiring an antidepressant drug treatment, but without current alcohol or drug dependence or unstable medical disease. Results An LFT is performed in 36.1% (116/321) of depressed patients. One fifth of antidepressant-treated patients who had an LFT evaluation had abnormal results. The most frequent causes of LFT abnormalities were: NAFLD (nonalcoholic fatty liver disease) (7/321; 2.1%), acute alcohol consumption (4/321; 1.2%), antidepressant-induced liver injury (3/321; 0.9%), hepatitis C virus infection (2/321; 0.6%) and heart failure (1/321; 0.3%). The cause of LFT abnormalities was unknown in 32% of patients (8/25) due to the absence of etiological investigations. Conclusion These results demonstrate that an LFT is infrequently performed by psychiatrists in depressed patients requiring an antidepressant drug. Baseline LFT assessment and observations during the first six months of antidepressant treatment may be useful for detection of patients with pre-existing liver disease such as NAFLD, and early identification of cases of antidepressant-induced liver injury. An increase in aminotransferase levels may be related to an underlying liver disease, but does not contraindicate antidepressant treatment. PMID:27171561

  11. Development of New, Low-Head Hydropower Turbine - Modeling & Laboratory Test DE-EE0005426

    SciTech Connect

    Krouse, Wayne

    2014-12-05

    Hydro Green Energy, LLC (HGE) will complete the design, fabrication and laboratory testing of a scaled, vertically stackable, low-head hydropower turbine called the Modular Bulb Turbine (MBT). HGE will also complete a summary report that includes the laboratory testing results and analysis of the tests. Project Goals: Design, model and test modular bulb turbine for installation in numerous HGE low-head hydropower projects at non-powered USACE dams. Project Results: The sub-scale prototype was tested successfully at a leading US hydraulic laboratory. Laboratory data results agreed well with predicted results from numerical modeling.

  12. Testing of the Semikron Validation AIPM Unit at Oak Ridge National Laboratory -- October 2004

    SciTech Connect

    Nelson, S.C.

    2004-11-12

    This report documents the electrical tests performed on the Semikron high-voltage automotive integrated power module (AIPM) at Oak Ridge National Laboratory (ORNL). Testing was performed in the 100-hp dynamometer test cell at the National Transportation Research Center.

  13. Good laboratory practices for biochemical genetic testing and newborn screening for inherited metabolic disorders.

    PubMed

    2012-04-06

    Biochemical genetic testing and newborn screening are essential laboratory services for the screening, detection, diagnosis, and monitoring of inborn errors of metabolism or inherited metabolic disorders. Under the Clinical Laboratory Improvement Amendments of 1988 (CLIA) regulations, laboratory testing is categorized on the basis of the level of testing complexity as either waived (i.e., from routine regulatory oversight) or nonwaived testing (which includes tests of moderate and high complexity). Laboratories that perform biochemical genetic testing are required by CLIA regulations to meet the general quality systems requirements for nonwaived testing and the personnel requirements for high-complexity testing. Laboratories that perform public health newborn screening are subject to the same CLIA regulations and applicable state requirements. As the number of inherited metabolic diseases that are included in state-based newborn screening programs continues to increase, ensuring the quality of performance and delivery of testing services remains a continuous challenge not only for public health laboratories and other newborn screening facilities but also for biochemical genetic testing laboratories. To help ensure the quality of laboratory testing, CDC collaborated with the Centers for Medicare & Medicaid Services, the Food and Drug Administration, the Health Resources and Services Administration, and the National Institutes of Health to develop guidelines for laboratories to meet CLIA requirements and apply additional quality assurance measures for these areas of genetic testing. This report provides recommendations for good laboratory practices that were developed based on recommendations from the Clinical Laboratory Improvement Advisory Committee, with additional input from the Secretary's Advisory Committee on Genetics, Health, and Society; the Secretary's Advisory Committee on Heritable Disorders in Newborns and Children; and representatives of newborn

  14. The national market for Medicare clinical laboratory testing: implications for payment reform.

    PubMed

    Gass Kandilov, Amy M; Pope, Gregory C; Kautter, John; Healy, Deborah

    2012-01-01

    Current Medicare payment policy for outpatient laboratory services is outdated. Future reforms, such as competitive bidding, should consider the characteristics of the laboratory market. To inform payment policy, we analyzed the structure of the national market for Medicare Part B clinical laboratory testing, using a 5-percent sample of 2006 Medicare claims data. The independent laboratory market is dominated by two firms--Quest Diagnostics and Laboratory Corporation of America. The hospital outreach market is not as concentrated as the independent laboratory market. Two subgroups of Medicare beneficiaries, those with end-stage renal disease and those residing in nursing homes, are each served in separate laboratory markets. Despite the concentrated independent laboratory market structure, national competitive bidding for non-patient laboratory tests could result in cost savings for Medicare.

  15. A risk score for predicting coronary artery disease in women with angina pectoris and abnormal stress test finding.

    PubMed

    Lo, Monica Y; Bonthala, Nirupama; Holper, Elizabeth M; Banks, Kamakki; Murphy, Sabina A; McGuire, Darren K; de Lemos, James A; Khera, Amit

    2013-03-15

    Women with angina pectoris and abnormal stress test findings commonly have no epicardial coronary artery disease (CAD) at catheterization. The aim of the present study was to develop a risk score to predict obstructive CAD in such patients. Data were analyzed from 337 consecutive women with angina pectoris and abnormal stress test findings who underwent cardiac catheterization at our center from 2003 to 2007. Forward selection multivariate logistic regression analysis was used to identify the independent predictors of CAD, defined by ≥50% diameter stenosis in ≥1 epicardial coronary artery. The independent predictors included age ≥55 years (odds ratio 2.3, 95% confidence interval 1.3 to 4.0), body mass index <30 kg/m(2) (odds ratio 1.9, 95% confidence interval 1.1 to 3.1), smoking (odds ratio 2.6, 95% confidence interval 1.4 to 4.8), low high-density lipoprotein cholesterol (odds ratio 2.9, 95% confidence interval 1.5 to 5.5), family history of premature CAD (odds ratio 2.4, 95% confidence interval 1.0 to 5.7), lateral abnormality on stress imaging (odds ratio 2.8, 95% confidence interval 1.5 to 5.5), and exercise capacity <5 metabolic equivalents (odds ratio 2.4, 95% confidence interval 1.1 to 5.6). Assigning each variable 1 point summed to constitute a risk score, a graded association between the score and prevalent CAD (ptrend <0.001). The risk score demonstrated good discrimination with a cross-validated c-statistic of 0.745 (95% confidence interval 0.70 to 0.79), and an optimized cutpoint of a score of ≤2 included 62% of the subjects and had a negative predictive value of 80%. In conclusion, a simple clinical risk score of 7 characteristics can help differentiate those more or less likely to have CAD among women with angina pectoris and abnormal stress test findings. This tool, if validated, could help to guide testing strategies in women with angina pectoris.

  16. What is the best strategy for investigating abnormal liver function tests in primary care? Implications from a prospective study

    PubMed Central

    Lilford, Richard J; Bentham, Louise M; Armstrong, Matthew J; Neuberger, James; Girling, Alan J

    2013-01-01

    Objective Evaluation of predictive value of liver function tests (LFTs) for the detection of liver-related disease in primary care. Design A prospective observational study. Setting 11 UK primary care practices. Participants Patients (n=1290) with an abnormal eight-panel LFT (but no previously diagnosed liver disease). Main outcome measures Patients were investigated by recording clinical features, and repeating LFTs, specific tests for individual liver diseases, and abdominal ultrasound scan. Patients were characterised as having: hepatocellular disease; biliary disease; tumours of the hepato-biliary system and none of the above. The relationship between LFT results and disease categories was evaluated by stepwise regression and logistic discrimination, with adjustment for demographic and clinical factors. True and False Positives generated by all possible LFT combinations were compared with a view towards optimising the choice of analytes in the routine LFT panel. Results Regression methods showed that alanine aminotransferase (ALT) was associated with hepatocellular disease (32 patients), while alkaline phosphatase (ALP) was associated with biliary disease (12 patients) and tumours of the hepatobiliary system (9 patients). A restricted panel of ALT and ALP was an efficient choice of analytes, comparing favourably with the complete panel of eight analytes, provided that 48 False Positives can be tolerated to obtain one additional True Positive. Repeating a complete panel in response to an abnormal reading is not the optimal strategy. Conclusions The LFT panel can be restricted to ALT and ALP when the purpose of testing is to exclude liver disease in primary care. PMID:23794594

  17. How personal experiences feature in women's accounts of use of information for decisions about antenatal diagnostic testing for foetal abnormality.

    PubMed

    France, Emma F; Wyke, Sally; Ziebland, Sue; Entwistle, Vikki A; Hunt, Kate

    2011-03-01

    There has been a striking growth in the availability of health-related information based on personal experience in recent years and internet users are often drawn towards other people's stories about their health. Accounts of other people's experiences might convey social and emotional information that is not otherwise available but little is known about how it is used or the implications of its use in practice. This paper examines how people refer to information about other people's experiences when accounting for decisions about antenatal diagnostic testing for foetal abnormality. We conducted a secondary analysis of 37 qualitative interviews undertaken across the UK with 36 women and nine of their male partners (eight couples were interviewed together) who talked about diagnostic testing for foetal abnormality in 55 pregnancies. When describing their decisions, respondents referred to examples of knowledge gleaned from their own and other individuals' experiences as well as information based on biomedical or clinical-epidemiological research (usually about the probabilities of having a child affected by health problems or the probability of diagnostic tests causing miscarriage). Both forms of knowledge were employed in people's accounts to illustrate the legitimacy and internal coherence of decisions taken. The analysis demonstrates the personally idiosyncratic ways that people reflect on and incorporate different types of information to add meaning to abstract ideas about risk, to imagine the consequences for their own lives and to help them to make sense of the decisions they faced.

  18. PEP Support Laboratory Leaching and Permeate Stability Tests

    SciTech Connect

    Russell, Renee L.; Peterson, Reid A.; Rinehart, Donald E.; Buchmiller, William C.

    2009-09-25

    Pacific Northwest National Laboratory (PNNL) has been tasked by Bechtel National Inc. (BNI) on the River Protection Project-Hanford Tank Waste Treatment and Immobilization Plant (RPP-WTP) project to perform research and development activities to resolve technical issues identified for the Pretreatment Facility (PTF). The Pretreatment Engineering Platform (PEP) was designed, constructed, and operated as part of a plan to respond to issue M12, "Undemonstrated Leaching Processes," of the External Flowsheet Review Team (EFRT) issue response plan.( ) The PEP is a 1/4.5-scale test platform designed to simulate the WTP pretreatment caustic leaching, oxidative leaching, ultrafiltration solids concentration, and slurry washing processes. The PEP replicates the WTP leaching processes using prototypic equipment and control strategies. A simplified flow diagram of the PEP system is shown in Figure 1.1. Two operating scenarios are currently being evaluated for the ultrafiltration process (UFP) and leaching operations. The first scenario has caustic leaching performed in the UFP-2 ultrafiltration feed vessels (i.e., vessel UFP-VSL-T02A in the PEP and vessels UFP-VSL-00002A and B in the WTP PTF). The second scenario has caustic leaching conducted in the UFP-1 ultrafiltration feed preparation vessels (i.e., vessels UFP-VSL-T01A and B in the PEP and vessels UFP-VSL-00001A and B in the WTP PTF). In both scenarios, 19-M sodium hydroxide solution (NaOH, caustic) is added to the waste slurry in the vessels to leach solid aluminum compounds (e.g., gibbsite, boehmite). Caustic addition is followed by a heating step that uses direct injection of steam to accelerate the leach process. Following the caustic leach, the vessel contents are cooled using vessel cooling jackets and/or external heat exchangers. The main difference between the two scenarios is that for leaching in UFP-VSL-T01A and B, the 19-M NaOH is added to un-concentrated waste slurry (3 to 8 wt% solids), while for leaching in

  19. 40 CFR Appendix II to Part 1054 - Duty Cycles for Laboratory Testing

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 34 2012-07-01 2012-07-01 false Duty Cycles for Laboratory Testing II Appendix II to Part 1054 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR.... 1054, App. II Appendix II to Part 1054—Duty Cycles for Laboratory Testing (a) Test handheld...

  20. 40 CFR Appendix II to Part 1054 - Duty Cycles for Laboratory Testing

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 33 2014-07-01 2014-07-01 false Duty Cycles for Laboratory Testing II Appendix II to Part 1054 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR.... 1054, App. II Appendix II to Part 1054—Duty Cycles for Laboratory Testing (a) Test handheld...

  1. 40 CFR Appendix II to Part 1054 - Duty Cycles for Laboratory Testing

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 34 2013-07-01 2013-07-01 false Duty Cycles for Laboratory Testing II Appendix II to Part 1054 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR.... 1054, App. II Appendix II to Part 1054—Duty Cycles for Laboratory Testing (a) Test handheld...

  2. 40 CFR Appendix II to Part 1054 - Duty Cycles for Laboratory Testing

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 33 2011-07-01 2011-07-01 false Duty Cycles for Laboratory Testing II Appendix II to Part 1054 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR.... 1054, App. II Appendix II to Part 1054—Duty Cycles for Laboratory Testing (a) Test handheld...

  3. 40 CFR Appendix II to Part 1054 - Duty Cycles for Laboratory Testing

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 32 2010-07-01 2010-07-01 false Duty Cycles for Laboratory Testing II Appendix II to Part 1054 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR.... 1054, App. II Appendix II to Part 1054—Duty Cycles for Laboratory Testing (a) Test handheld...

  4. 30 CFR 14.21 - Laboratory-scale flame test apparatus.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Laboratory-scale flame test apparatus. 14.21 Section 14.21 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR TESTING... Technical Requirements § 14.21 Laboratory-scale flame test apparatus. The principal parts of the...

  5. 30 CFR 14.21 - Laboratory-scale flame test apparatus.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Laboratory-scale flame test apparatus. 14.21 Section 14.21 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR TESTING... Technical Requirements § 14.21 Laboratory-scale flame test apparatus. The principal parts of the...

  6. 30 CFR 14.21 - Laboratory-scale flame test apparatus.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Laboratory-scale flame test apparatus. 14.21 Section 14.21 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR TESTING... Technical Requirements § 14.21 Laboratory-scale flame test apparatus. The principal parts of the...

  7. 30 CFR 14.21 - Laboratory-scale flame test apparatus.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Laboratory-scale flame test apparatus. 14.21 Section 14.21 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR TESTING... Technical Requirements § 14.21 Laboratory-scale flame test apparatus. The principal parts of the...

  8. 30 CFR 14.21 - Laboratory-scale flame test apparatus.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Laboratory-scale flame test apparatus. 14.21 Section 14.21 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR TESTING... Technical Requirements § 14.21 Laboratory-scale flame test apparatus. The principal parts of the...

  9. King County Metro Transit: Allison Hybrid Electric Transit Bus Laboratory Testing

    SciTech Connect

    Hayes, R. R.; Williams, A.; Ireland, J.; Walkowicz, K.

    2006-09-01

    Paper summarizes chassis dynamometer testing of two 60-foot articulated transit buses, one conventional and one hybrid, at NREL's ReFUEL Laboratory. It includes experimental setup, test procedures, and results from vehicle testing performed at the NREL ReFUEL laboratory.

  10. 40 CFR 270.63 - Permits for land treatment demonstrations using field test or laboratory analyses.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... the field test or laboratory analyses, or as a two-phase facility permit covering the field tests, or... laboratory analyses. (b) If the Director finds that a phased permit may be issued, he will establish, as requirements in the first phase of the facility permit, conditions for conducting the field tests or...

  11. 40 CFR 270.63 - Permits for land treatment demonstrations using field test or laboratory analyses.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... the field test or laboratory analyses, or as a two-phase facility permit covering the field tests, or... laboratory analyses. (b) If the Director finds that a phased permit may be issued, he will establish, as requirements in the first phase of the facility permit, conditions for conducting the field tests or...

  12. 40 CFR 270.63 - Permits for land treatment demonstrations using field test or laboratory analyses.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... the field test or laboratory analyses, or as a two-phase facility permit covering the field tests, or... laboratory analyses. (b) If the Director finds that a phased permit may be issued, he will establish, as requirements in the first phase of the facility permit, conditions for conducting the field tests or...

  13. 40 CFR 270.63 - Permits for land treatment demonstrations using field test or laboratory analyses.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... the field test or laboratory analyses, or as a two-phase facility permit covering the field tests, or... laboratory analyses. (b) If the Director finds that a phased permit may be issued, he will establish, as requirements in the first phase of the facility permit, conditions for conducting the field tests or...

  14. 40 CFR 270.63 - Permits for land treatment demonstrations using field test or laboratory analyses.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... conducting such tests or analyses. The owner or operator must also submit all data collected during the field... demonstrations using field test or laboratory analyses. 270.63 Section 270.63 Protection of Environment... using field test or laboratory analyses. (a) For the purpose of allowing an owner or operator to...

  15. An Alternative to the Physiological Psychology Laboratory: Identification of an Unknown Drug Through Behavioral Testing.

    ERIC Educational Resources Information Center

    Schumacher, Susan J.

    1982-01-01

    A laboratory project introduced physiological psychology students to research by requiring them to identify an unknown drug given to laboratory animals. Students read material about drugs and animal drug studies, designed behavioral tests, constructed the testing apparatus, conducted the tests, and wrote progress reports. (SR)

  16. Proficiency testing. Its role in a voluntary clinical Laboratory Accreditation Program.

    PubMed

    Duckworth, J K

    1988-04-01

    The author's long experience as Chairman of the Laboratory Accreditation Program of the College of American Pathologists provides the background for this article. Laboratory accreditation and proficiency testing have now become an established part of the clinical laboratories in the United States. This article attempts to demonstrate the relationship between proficiency testing and accreditation, and highlights some of the current problems and future challenges facing proficiency testing as pertains to accreditation.

  17. Use of laboratory test results in patient management by clinicians in Malawi

    PubMed Central

    Moyo, Kundai; Porter, Carol; Chilima, Ben; Mwenda, Reuben; Kabue, Mark; Zungu, Lutho; Sarr, Abdoulaye

    2016-01-01

    Background Malawi has a high burden of infectious disease. The expansion of programmes targeting these diseases requires a strong laboratory infrastructure to support both diagnosis and treatment. Objectives To assess the use of laboratory test results in patient management and to determine the requirements for improving laboratory services. Methods A cross-sectional study was conducted in 2012 to survey practising clinicians. Two hospitals were purposively selected for observations of clinicians ordering laboratory tests. Twelve management-level key informants were interviewed. Descriptive statistics were conducted. Results A total of 242 clinicians were identified and 216 (89%) were interviewed. Of these, 189 (87%) reported doubting laboratory test results at some point. Clinicians most often doubted the quality of haematology (67%), followed by malaria (53%) and CD4 (22%) test results. A total of 151 (70%) clinicians reported using laboratory tests results in patient management. Use of laboratory test results at all times in patient management varied by the type of health facility (P < 0.001). Ninety-one percent of clinicians reported that laboratories required infrastructure improvement. During 97 observations of clinicians’ use of laboratory test results, 80 tests were ordered, and 73 (91%) of these were used in patient management. Key informants reported that the quality of laboratory services was good and useful, but that services were often unavailable. Conclusion Gaps in the public laboratory system were evident. Key recommendations to enhance the use of laboratory test results in patient management were to strengthen the supply chain, reduce turn-around times, improve the test menu and improve the laboratory infrastructure. PMID:27213139

  18. 49 CFR Appendix B to Part 219 - Designation of Laboratory for Post-Accident Toxicological Testing

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Designation of Laboratory for Post-Accident.... 219, App. B Appendix B to Part 219—Designation of Laboratory for Post-Accident Toxicological Testing The following laboratory is currently designated to conduct post-accident toxicological analysis...

  19. 49 CFR Appendix B to Part 219 - Designation of Laboratory for Post-Accident Toxicological Testing

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 4 2012-10-01 2012-10-01 false Designation of Laboratory for Post-Accident.... 219, App. B Appendix B to Part 219—Designation of Laboratory for Post-Accident Toxicological Testing The following laboratory is currently designated to conduct post-accident toxicological analysis...

  20. 49 CFR Appendix B to Part 219 - Designation of Laboratory for Post-Accident Toxicological Testing

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 4 2011-10-01 2011-10-01 false Designation of Laboratory for Post-Accident.... 219, App. B Appendix B to Part 219—Designation of Laboratory for Post-Accident Toxicological Testing The following laboratory is currently designated to conduct post-accident toxicological analysis...

  1. Tried and True: Tested Ideas for Teaching and Learning from the Regional Educational Laboratories.

    ERIC Educational Resources Information Center

    Levinson, Luna; Stonehill, Robert

    This collection of 16 tested ideas for improving teaching and learning evolved from the work of the 1995 Proven Laboratory Practices Task Force charged with identifying and collecting the best and most useful work from the Regional Educational Laboratories. The Regional Educational Laboratory program is the largest research and development…

  2. Draft Test Guideline: Special Considerations for Conducting Aquatic Laboratory Studies

    EPA Pesticide Factsheets

    The following draft test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review.

  3. 33 CFR 209.340 - Laboratory investigations and materials testing.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... hydraulic laboratories, and to the Inter-Agency Sedimentation Project. (c) References. (1) AR 37-20. (2) AR... units of government, foreign governments and private firms under the following conditions: (1) The work will be performed on a cost reimbursable basis. (2) Work may be performed for State and local units...

  4. Gender, Race, and Diet Affect Platelet Function Tests in Normal Subjects Contributing to a High Rate of Abnormal Results

    PubMed Central

    Miller, Connie H.; Rice, Anne S.; Garrett, Katherine; Stein, Sidney F.

    2015-01-01

    Summary To assess sources of variability in platelet function tests in normal subjects, 64 healthy young adults were tested on 2–6 occasions at 2 week intervals using 4 methods: platelet aggregation (AGG) in platelet-rich plasma (PRP) in the Bio/Data PAP-4 Aggregometer (BD) and Chrono-Log Lumi-Aggregometer (CL); and AGG in whole blood (WB) in the CL and Multiplate Platelet Function Analyzer (MP), with ATP release (REL) in CL-PRP and CL-WB. Food and medication exposures were recorded prospectively for 2 weeks prior to each blood draw. At least one AGG abnormality was seen in 21% of 81 drug-free specimens with CL-PRP, 15% with CL-WB, 13% with BD-PRP, and 6% with MP-WB, increasing with inclusion of REL to 28% for CL-PRP and 30% for CL-WB. Epinephrine AGG and REL were significantly reduced in males (P<0.0001). Ristocetin AGG and collagen and thrombin REL were significantly reduced in Blacks (P<0.0001). One-third of specimens drawn following flavonoid-rich food exposures had aberrant results, compared to 8.5% of specimens without such exposures (P=0.0035). PRP tests had less intra-individual variation than WB tests. Gender, race, diet, and test system affected results of platelet function testing in healthy subjects, suggesting caution when interpreting the results of platelet function testing in patients. PMID:24617520

  5. Sandia National Laboratories Electrochemical Storage System Abuse Test Procedure Manual

    SciTech Connect

    Unkelhaeuser, Terry; Smallwood David

    1999-07-01

    The series of tests described in this report are intended to simulate actual use and abuse conditions and internally initiated failures that may be experienced in electrochemical storage systems (ECSS). These tests were derived from Failure Mode and Effect Analysis, user input, and historical abuse testing. The tests are to provide a common framework for various ECSS technologies. The primary purpose of testing is to gather response information to external/internal inputs. Some tests and/or measurements may not be required for some ECSS technologies and designs if it is demonstrated that a test is not applicable, and the measurements yield no useful information.

  6. Audio Development Laboratory (ADL) User Test Planning Guide

    NASA Technical Reports Server (NTRS)

    Romero, Andy

    2012-01-01

    Test process, milestones and inputs are unknowns to first-time users of the ADL. The User Test Planning Guide aids in establishing expectations for both NASA and non-NASA facility customers. The potential audience for this guide includes both internal and commercial spaceflight hardware/software developers. It is intended to assist their test engineering personnel in test planning and execution. Material covered includes a roadmap of the test process, roles and responsibilities of facility and user, major milestones, facility capabilities, and inputs required by the facility. Samples of deliverables, test article interfaces, and inputs necessary to define test scope, cost, and schedule are included as an appendix to the guide.

  7. Clinical Pharmacogenetic Testing and Application: Laboratory Medicine Clinical Practice Guidelines

    PubMed Central

    Kim, Sollip; Yun, Yeo-Min; Chae, Hyo-Jin; Cho, Hyun-Jung; Ji, Misuk; Kim, In-Suk; Wee, Kyung-A; Lee, Woochang; Song, Sang Hoon; Woo, Hye In

    2017-01-01

    Pharmacogenetic testing for clinical applications is steadily increasing. Correct and adequate use of pharmacogenetic tests is important to reduce unnecessary medical costs and adverse patient outcomes. This document contains recommended pharmacogenetic testing guidelines for clinical application, interpretation, and result reporting through a literature review and evidence-based expert opinions for the clinical pharmacogenetic testing covered by public medical insurance in Korea. This document aims to improve the utility of pharmacogenetic testing in routine clinical settings. PMID:28029011

  8. Clinical Pharmacogenetic Testing and Application: Laboratory Medicine Clinical Practice Guidelines.

    PubMed

    Kim, Sollip; Yun, Yeo Min; Chae, Hyo Jin; Cho, Hyun Jung; Ji, Misuk; Kim, In Suk; Wee, Kyung A; Lee, Woochang; Song, Sang Hoon; Woo, Hye In; Lee, Soo Youn; Chun, Sail

    2017-03-01

    Pharmacogenetic testing for clinical applications is steadily increasing. Correct and adequate use of pharmacogenetic tests is important to reduce unnecessary medical costs and adverse patient outcomes. This document contains recommended pharmacogenetic testing guidelines for clinical application, interpretation, and result reporting through a literature review and evidence-based expert opinions for the clinical pharmacogenetic testing covered by public medical insurance in Korea. This document aims to improve the utility of pharmacogenetic testing in routine clinical settings.

  9. Determination of basic friction angle using various laboratory tests.

    NASA Astrophysics Data System (ADS)

    Jang, Bo-An

    2016-04-01

    The basic friction angle of rock is an important factor of joint shear strength and is included within most shear strength criteria. It can be measured by direct shear test, triaxial compression test and tilt test. Tilt test is mostly used because it is the simplest method. However, basic friction angles measured using tilt test for same rock type or for one sample are widely distributed and often do not show normal distribution. In this research, the basic friction angles for the Hangdeung granite form Korea and Berea sandstone from USA are measured accurately using direct shear test and triaxial compression test. Then basic friction angles are again measured using tilt tests with various conditions and are compared with those measured using direct shear test and triaxial compression test to determine the optimum condition of tilt test. Three types of sliding planes, such as planes cut by saw and planes polished by #100 and #600 grinding powders, are prepared. When planes are polished by #100 grinding powder, the basic friction angles measured using direct shear test and triaxial compression test are very consistent and show narrow ranges. However, basic friction angles show wide ranges when planes are cut by saw and are polished by #600 grinding powder. The basic friction angle measured using tilt test are very close to those measured using direct shear test and triaxial compression test when plane is polished by #100 grinding powder. When planes are cut by saw and are polished by #600 grinding powder, basic friction angles measured using tilt test are slightly different. This indicates that tilt test with plane polished by #100 grinding powder can yield an accurate basic friction angle. In addition, the accurate values are obtained not only when planes are polished again after 10 times of tilt test, but values are averaged by more 30 times of tests.

  10. Psychophysiological stress testing in postinfarction patients. Psychological correlates of cardiovascular arousal and abnormal cardiac responses.

    PubMed

    Zotti, A M; Bettinardi, O; Soffiantino, F; Tavazzi, L; Steptoe, A

    1991-04-01

    The psychophysiological responses to two mental stress tests (mental arithmetic and an interactive concentration task) were assessed in 168 unmedicated, male, postinfarction patients 36-69 years old. Patients also completed a standard battery of psychological tests. Psychophysiological responses were generally unrelated to age and education. Comparison of patients scoring high (more than 75%) and low (less than 25%) relative to the normal population on psychological measures indicated that heart rate and blood pressure responses to mental stress tests were significantly greater in those reporting low than in those reporting high neuroticism. The study population was subsequently divided into high, medium, and low cardiovascular responders on the basis of rate-pressure product reactions to the two stress tests. The three cardiovascular response groups did not differ in age, interval between myocardial infarction and stress testing, ejection fraction, incidence of exercise-induced ischemia, or ischemic signs during Holter monitoring. However, the high cardiovascular responders were more likely to manifest possible or definite electrocardiographic signs of ischemia or significant arrhythmia during mental stress testing than were the medium or low cardiovascular responders (50% versus 19.6% and 7%, respectively). High cardiovascular responders also reported lower levels of trait anxiety, neuroticism, psychophysiological symptoms, and depression.

  11. Laboratory test and acoustic analysis of cabin treatment for propfan test assessment aircraft

    NASA Technical Reports Server (NTRS)

    Kuntz, H. L.; Gatineau, R. J.

    1991-01-01

    An aircraft cabin acoustic enclosure, built in support of the Propfan Test Assessment (PTA) program, is described. Helmholtz resonators were attached to the cabin trim panels to increase the sidewall transmission loss (TL). Resonators (448) were located between the trim panels and fuselage shell. In addition, 152 resonators were placed between the enclosure and aircraft floors. The 600 resonators were each tuned to a 235 Hz resonance frequency. After flight testing on the PTA aircraft, the enclosure was tested in the Kelly Johnson R and D Center Acoustics Lab. Laboratory noise reduction (NR) test results are discussed. The enclosure was placed in a Gulfstream 2 fuselage section. Broadband (138 dB overall SPL) and tonal (149 dB overall SPL) excitations were used in the lab. Tonal excitation simulated the propfan flight test excitation. The fundamental tone was stepped in 2 Hz intervals from 225 through 245 Hz. The resonators increase the NR of the cabin walls around the resonance frequency of the resonator array. The effects of flanking, sidewall absorption, cabin adsorption, resonator loading of trim panels, and panel vibrations are presented. Increases in NR of up to 11 dB were measured.

  12. Economic Analysis of Requests for Laboratory Tests in Primary Health Care Centers

    PubMed Central

    Zunic, Lejla

    2012-01-01

    Introduction: Operation of the Primary health care center and Medical-biochemical laboratories depends on the number of performed laboratory tests. The number of unnecessary tests significantly affect the operation of health institutions. Material and methods: We analyzed the 1000 requests for laboratory tests at the Primary Health Care Centre in Gracanica from primary care units. Based on the requests for laboratory diagnostics advisable diagnoses from primary health care unit in the Primary Health Care Center (PHC) we made an economic analysis of the total required laboratory tests in the requests for laboratory diagnosis. Incorporating the economic analysis of laboratory tests in requests for laboratory diagnosis by doctors in primary health care (PHC) and the economic analysis of laboratory tests by the disease in primary health care. Results: The economic value of 5333 laboratory tests was 84 312 points (1 point is 0.80 KM). Of the total value of the index score requirements of GPs are 44, 1%, the requirement of family doctors account for 40% and requirements of other specialists make up 15, 9%.. Discussion: In the requests of the PHC units for laboratory tests are required all levels of services: urine, CBC, SE, glucose, bilirubine, ALT, AST, AF, CK, cholesterol, HDL chol., triglicerdes, creatinine, urea, uric acid, CRP, fibrinogen, calcium and phosphorus. The following requests are the most common laboratory tests: urine, CBC, blood glucose, cholesterol, triglycerides, aminotransferases, creatinine, urea. The doctors in family practice most often requested: blood glucose, urine, CBC, SE, TGL. , Chol., ALT, AST, creatinine and urea. General practitioners were demanding more cholesterol and triglycerides, and family medicine doctors were demanding less cholesterol and triglycerides and more often CRP, fibrinogen, ALT, AST, what from the level of economic cost analysis rises the issue whether this was justified? PMID:23322950

  13. 49 CFR 199.107 - Drug testing laboratory.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY DRUG AND ALCOHOL TESTING Drug Testing... of records, at any time, by the operator, the Administrator, and if the operator is subject to...

  14. Antimicrobial Testing Methods & Procedures Developed by EPA's Microbiology Laboratory

    EPA Pesticide Factsheets

    We develop antimicrobial testing methods and standard operating procedures to measure the effectiveness of hard surface disinfectants against a variety of microorganisms. Find methods and procedures for antimicrobial testing.

  15. Jet Propulsion Laboratory Environmental Verification Processes and Test Effectiveness

    NASA Technical Reports Server (NTRS)

    Hoffman, Alan R.; Green, Nelson W.

    2006-01-01

    Viewgraphs on the JPL processes for enviornmental verification and testing of aerospace systems is presented. The topics include: 1) Processes: a) JPL Design Principles b) JPL Flight Project Practices; 2) Environmental Verification; and 3) Test Effectiveness Assessment: Inflight Anomaly Trends.

  16. Materials and Nondestructive Evaluation Laboratoriers: User Test Planning Guide

    NASA Technical Reports Server (NTRS)

    Schaschl, Leslie

    2011-01-01

    The Materials and Nondestructive Evaluation Laboratory process, milestones and inputs are unknowns to first-time users. The Materials and Nondestructive Evaluation Laboratory Planning Guide aids in establishing expectations for both NASA and non- NASA facility customers. The potential audience for this guide includes both internal and commercial spaceflight hardware developers. It is intended to assist their project engineering personnel in materials analysis planning and execution. Material covered includes a roadmap of the analysis process, roles and responsibilities of facility and user, major milestones, facility capabilities, and inputs required by the facility. Samples of deliverables, products, and inputs necessary to define scope of analysis, cost, and schedule are included as an appendix to the guide.

  17. FRACTIONAL CRYSALLIZATION LABORATORY TESTS WITH SIMULATED TANK WASTE

    SciTech Connect

    HERTING DL

    2007-11-29

    Results are presented for several simulated waste tests related to development of the fractional crystallization process. Product salt dissolution rates were measured to support pilot plant equipment design. Evaporation tests were performed to evaluate the effects of organics on slurry behavior and to determine optimum antifoam addition levels. A loss-of-power test was performed to support pilot plant accident scenario analysis. Envelope limit tests were done to address variations in feed composition.

  18. Laboratory Evaluation of EGS Shear Stimulation-Test 001

    DOE Data Explorer

    Bauer, Steve

    2014-07-29

    this is the results of an initial setup-shakedon test in order to develop the plumbing system for this test design. a cylinder of granite with offset holes was jacketed and subjected to confining pressure and low temperature (85C) and pore water pressure. flow through the sample was developed at different test stages.

  19. Maintaining data quality in an environmental testing laboratory

    SciTech Connect

    Cohen, Roy J.

    2001-03-05

    In today's competitive and highly litigious world, it is critical that any laboratory generating data for the environmental and allied industries have a world-class Quality Assurance Program. This Plan must conform to the requirements of every agency and client with whom the lab does business. The goal of such a program is data defensibility; i.e., data validity. Data (usually qualitative analyte [compound or element] identifications and quantitative numerical results) are the end results of nearly all analytical laboratory processes, and the source of revenue. Clients pay for results. The clients expect the results to be accurate, precise, and repeatable. If their data has to go to court, the laboratory will be called upon to defend the accuracy and precision of their work. Without a strong QA program, this will be impossible. The potential implications and repercussions of non-defensible lab data are far-reaching and very costly in terms of loss of future revenues and in legal judgments.

  20. Screening for chromosomal abnormalities using combined test in the first trimester of pregnancy

    PubMed Central

    Park, Soo Yeon; Jang, In Ae; Lee, Min Ah; Kim, Young Ju; Chun, Sun Hee

    2016-01-01

    Objective This study was designed to review the screening performance of combined test at the Ewha Womans University Mokdong hospital. Methods All women admitted for routine antenatal care between January 1st 2008 and December 31st 2012 with a known pregnancy outcome were included in this study, totaling 1,156 women with singleton pregnancies presenting at 10 to 13 weeks of gestation. Women were offered screening using a combination of maternal serum pregnancy-associated plasma protein-A, free β-human chorionic gonadotropin and fetal nuchal translucency thickness. Those with an estimated risk of ≥1 in 250 of carrying a fetus with trisomy 21 or ≥1 in 300 risk of trisomy 18 were offered genetic counseling with the option of an invasive diagnostic test. Results The median of gestational age was 11+3 weeks, the median of crown-rump length was 47.1 mm, and the median age of the women was 31 years. The detection rate was 80% for trisomy 21 (4 of 5) and 100% for trisomy 13 and 18 (all 2). The false-positive rate was 7.73% for trisomy 21 and 1.21% for trisomy 18. Conclusion This study was the first large population study performed with the aim of analyzing the performance of the combined test in Korea. This study demonstrated that the detection rates and other figures of the first trimester combined test are comparable to the results reported in other papers worldwide. Consequently, if strict conditions for good screening outcomes are achieved, the first trimester combined test might well be the earliest detectable screening, improving detection rates without increasing karyotyping or economic and other implications that inevitably ensue. PMID:27668198

  1. Data reproducibility of pace strategy in a laboratory test run

    PubMed Central

    de França, Elias; Xavier, Ana Paula; Hirota, Vinicius Barroso; Côrrea, Sônia Cavalcanti; Caperuto, Érico Chagas

    2016-01-01

    This data paper contains data related to a reproducibility test for running pacing strategy in an intermittent running test until exhaustion. Ten participants underwent a crossover study (test and retest) with an intermittent running test. The test was composed of three-minute sets (at 1 km/h above Onset Blood Lactate Accumulation) until volitional exhaustion. To assess pace strategy change, in the first test participants chose the rest time interval (RTI) between sets (ranging from 30 to 60 s) and in the second test the maximum RTI values were either the RTI chosen in the first test (maximum RTI value), or less if desired. To verify the reproducibility of the test, rating perceived exertion (RPE), heart rate (HR) and blood plasma lactate concentration ([La]p) were collected at rest, immediately after each set and at the end of the tests. As results, RTI, RPE, HR, [La]p and time to exhaustion were not statistically different (p>0.05) between test and retest, as well as they demonstrated good intraclass correlation. PMID:27081672

  2. Moving from the laboratory to the field: Adding natural environmental conditions to toxicology testing

    EPA Science Inventory

    While laboratory toxicology tests are generally easy to perform, cost effective and readily interpreted, they have been criticized for being unrealistic. In contrast, field tests are considered realistic while producing results that are difficult to interpret and expensive. To ...

  3. Quality assurance practices in Europe: a survey of molecular genetic testing laboratories.

    PubMed

    Berwouts, Sarah; Fanning, Katrina; Morris, Michael A; Barton, David E; Dequeker, Elisabeth

    2012-11-01

    In the 2000s, a number of initiatives were taken internationally to improve quality in genetic testing services. To contribute to and update the limited literature available related to this topic, we surveyed 910 human molecular genetic testing laboratories, of which 291 (32%) from 29 European countries responded. The majority of laboratories were in the public sector (81%), affiliated with a university hospital (60%). Only a minority of laboratories was accredited (23%), and 26% was certified. A total of 22% of laboratories did not participate in external quality assessment (EQA) and 28% did not use reference materials (RMs). The main motivations given for accreditation were to improve laboratory profile (85%) and national recognition (84%). Nearly all respondents (95%) would prefer working in an accredited laboratory. In accredited laboratories, participation in EQA (P<0.0001), use of RMs (P=0.0014) and availability of continuous education (CE) on medical/scientific subjects (P=0.023), specific tasks (P=0.0018), and quality assurance (P<0.0001) were significantly higher than in non-accredited laboratories. Non-accredited laboratories expect higher restriction of development of new techniques (P=0.023) and improvement of work satisfaction (P=0.0002) than accredited laboratories. By using a quality implementation score (QIS), we showed that accredited laboratories (average score 92) comply better than certified laboratories (average score 69, P<0.001), and certified laboratories better than other laboratories (average score 44, P<0.001), with regard to the implementation of quality indicators. We conclude that quality practices vary widely in European genetic testing laboratories. This leads to a potentially dangerous situation in which the quality of genetic testing is not consistently assured.

  4. Canadian Public Health Laboratory Network laboratory guidelines for the use of direct tests to detect syphilis in Canada

    PubMed Central

    Tsang, Raymond SW; Morshed, Muhammad; Chernesky, Max A; Jayaraman, Gayatri C; Kadkhoda, Kamran

    2015-01-01

    Treponema pallidum subsp. pallidum and/or its nucleic acid can be detected by various methods such as microscopy, rabbit infectivity test or polymerase chain reaction (PCR) tests. The rabbit infectivity test for T. pallidum, although very sensitive, has been discontinued from most laboratories due to ethical issues related to the need for animal inoculation with live T. pallidum, the technically demanding procedure and long turnaround time for results, thus making it impractical for routine diagnostic use. Dark-field and phase-contrast microscopy are still useful at clinic- or hospital-based laboratories for near-bedside detection of T. pallidum in genital, skin or mucous lesions although their availability is decreasing. The lack of reliable and specific anti-T. pallidum antibodies and its inferior sensitivity to PCR may explain why the direct fluorescent antibody test for T. pallidum is not widely available for clinical use. Immunohistochemical staining for T. pallidum also depends on the availability of specific antibodies, and the method is only applicable for histopathological examination of biopsy and autopsy specimens necessitating an invasive specimen collection approach. With recent advances in molecular diagnostics, PCR is considered to be the most reliable, versatile and practical for laboratories to implement. In addition to being an objective and sensitive test for direct detection of Treponema pallidum subsp. pallidum DNA in skin and mucous membrane lesions, the resulting PCR amplicons from selected gene targets can be further characterized for antimicrobial (macrolide) susceptibility testing, strain typing and identification of T. pallidum subspecies. PMID:25798160

  5. 9 CFR 54.11 - Approval of laboratories to run official scrapie tests and official genotype tests.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... official scrapie tests and official genotype tests. 54.11 Section 54.11 Animals and Animal Products ANIMAL... LIVESTOCK OR POULTRY DISEASES CONTROL OF SCRAPIE Scrapie Indemnification Program § 54.11 Approval of laboratories to run official scrapie tests and official genotype tests. (a) State, Federal, and...

  6. Idaho National Engineering Laboratory, Test Area North, Hangar 629 -- Photographs, written historical and descriptive data

    SciTech Connect

    1994-12-31

    The report describes the history of the Idaho National Engineering Laboratory`s Hangar 629. The hangar was built to test the possibility of linking jet engine technology with nuclear power. The history of the project is described along with the development and eventual abandonment of the Flight Engine Test hangar. The report contains historical photographs and architectural drawings.

  7. Test and evaluation of an Argonne National Laboratory bulk assay calorimeter

    SciTech Connect

    Rodenburg, W.W.; Fellers, C.L.; Lemming, J.F.

    1981-06-30

    The Argonne National Laboratory bulk assay calorimeter (BAC) was subjected to a series of tests, using plutonium-238 heat standards, to evaluate the performance of the calorimeter over its operating range. The results of these tests provide baseline information of the instrument performance under laboratory conditions.

  8. 42 CFR 493.1453 - Condition: Laboratories performing high complexity testing; clinical consultant.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... testing; clinical consultant. 493.1453 Section 493.1453 Public Health CENTERS FOR MEDICARE & MEDICAID... Condition: Laboratories performing high complexity testing; clinical consultant. The laboratory must have a clinical consultant who meets the requirements of § 493.1455 of this subpart and provides...

  9. 42 CFR 493.1415 - Condition: Laboratories performing moderate complexity testing; clinical consultant.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... complexity testing; clinical consultant. 493.1415 Section 493.1415 Public Health CENTERS FOR MEDICARE... § 493.1415 Condition: Laboratories performing moderate complexity testing; clinical consultant. The laboratory must have a clinical consultant who meets the qualification requirements of § 493.1417 of...

  10. 7 CFR 91.37 - Standard hourly fee rate for laboratory testing, analysis, and other services.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Standard hourly fee rate for laboratory testing, analysis, and other services. 91.37 Section 91.37 Agriculture Regulations of the Department of Agriculture... AGRICULTURE (CONTINUED) COMMODITY LABORATORY TESTING PROGRAMS SERVICES AND GENERAL INFORMATION Fees...

  11. 7 CFR 91.37 - Standard hourly fee rate for laboratory testing, analysis, and other services.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 3 2011-01-01 2011-01-01 false Standard hourly fee rate for laboratory testing, analysis, and other services. 91.37 Section 91.37 Agriculture Regulations of the Department of Agriculture... AGRICULTURE (CONTINUED) COMMODITY LABORATORY TESTING PROGRAMS SERVICES AND GENERAL INFORMATION Fees...

  12. 42 CFR 414.508 - Payment for a new clinical diagnostic laboratory test.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 3 2014-10-01 2014-10-01 false Payment for a new clinical diagnostic laboratory test. 414.508 Section 414.508 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF... HEALTH SERVICES Payment for New Clinical Diagnostic Laboratory Tests § 414.508 Payment for a new...

  13. 42 CFR 414.508 - Payment for a new clinical diagnostic laboratory test.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Payment for a new clinical diagnostic laboratory test. 414.508 Section 414.508 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF... SERVICES Payment for New Clinical Diagnostic Laboratory Tests § 414.508 Payment for a new...

  14. 42 CFR 414.508 - Payment for a new clinical diagnostic laboratory test.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 3 2011-10-01 2011-10-01 false Payment for a new clinical diagnostic laboratory test. 414.508 Section 414.508 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF... SERVICES Payment for New Clinical Diagnostic Laboratory Tests § 414.508 Payment for a new...

  15. 42 CFR 414.508 - Payment for a new clinical diagnostic laboratory test.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 3 2012-10-01 2012-10-01 false Payment for a new clinical diagnostic laboratory test. 414.508 Section 414.508 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF... HEALTH SERVICES Payment for New Clinical Diagnostic Laboratory Tests § 414.508 Payment for a new...

  16. 42 CFR 414.508 - Payment for a new clinical diagnostic laboratory test.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 3 2013-10-01 2013-10-01 false Payment for a new clinical diagnostic laboratory test. 414.508 Section 414.508 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF... HEALTH SERVICES Payment for New Clinical Diagnostic Laboratory Tests § 414.508 Payment for a new...

  17. LABORATORY TOXICITY TESTS FOR EVALUATING POTENTIAL EFFECTS OF ENDOCRINE-DISRUPTING COMPOUNDS

    EPA Science Inventory

    The scope of the Laboratory Testing Work Group was to evaluate methods for testing aquatic and terrestrial invertebrates in the laboratory. Specifically, discussions focused on the following objectives: 1) assess the extent to which consensus-based standard methods and other pub...

  18. A comparison of relative toxicity rankings by some small-scale laboratory tests

    NASA Technical Reports Server (NTRS)

    Hilado, C. J.; Cumming, H. J.

    1977-01-01

    Small-scale laboratory tests for fire toxicity, suitable for use in the average laboratory hood, are needed for screening and ranking materials on the basis of relative toxicity. The performance of wool, cotton, and aromatic polyamide under several test procedures is presented.

  19. History of the use of HPV testing in cervical screening and in the management of abnormal cervical screening results.

    PubMed

    Cox, J Thomas

    2009-07-01

    Twenty years have passed since the first studies using human papillomavirus (HPV) testing began in clinical settings. At that time controversy regarding the role of HPV in cervical carcinogenesis still divided the scientific world. Epidemiological and natural history studies on HPV and cervical cancer in the ensuing two decades secured the necessary role of high-risk (carcinogenic) HPV in the genesis of cervical cancer, providing the rationale for testing for its cause. Subsequently, cross sectional studies and large randomized trials have provided clinical validation for high-risk HPV testing in triage of atypical squamous cells of undetermined significance (ASC-US), in postcolposcopy management of women referred for ASC-US, atypical squamous cells "cannot rule out high grade" (ASC-H), atypical glandular cells "not otherwise specified" (AGC NOS) and low grade squamous intraepithelial lesion (LSIL) and not found to have cervical intraepithelial neoplasia (CIN) 2+ or adenocarcinoma in situ (AIS) at initial colposcopy, in post-treatment of CIN 2+ surveillance, and in cotesting with the Papanicolaou (Pap) test of women age 30 and over. This is the story of the road traveled that brought the clinical use of HPV testing from its genesis only a few years after Dr. zur Hausen's discovery to its present eminent role in both primary cervical cancer screening and abnormal Pap management.

  20. 23 CFR 637.209 - Laboratory and sampling and testing personnel qualifications.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... the FHWA. (3) After June 29, 2000, any non-STD designated laboratory which performs IA sampling and... testing data to be used in the acceptance decision or the IA program shall be executed by qualified... same project: Verification testing, quality control testing, IA testing, or dispute resolution testing....

  1. 23 CFR 637.209 - Laboratory and sampling and testing personnel qualifications.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... the FHWA. (3) After June 29, 2000, any non-STD designated laboratory which performs IA sampling and... testing data to be used in the acceptance decision or the IA program shall be executed by qualified... same project: Verification testing, quality control testing, IA testing, or dispute resolution testing....

  2. 23 CFR 637.209 - Laboratory and sampling and testing personnel qualifications.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... the FHWA. (3) After June 29, 2000, any non-STD designated laboratory which performs IA sampling and... testing data to be used in the acceptance decision or the IA program shall be executed by qualified... same project: Verification testing, quality control testing, IA testing, or dispute resolution testing....

  3. 23 CFR 637.209 - Laboratory and sampling and testing personnel qualifications.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... the FHWA. (3) After June 29, 2000, any non-STD designated laboratory which performs IA sampling and... testing data to be used in the acceptance decision or the IA program shall be executed by qualified... same project: Verification testing, quality control testing, IA testing, or dispute resolution testing....

  4. 23 CFR 637.209 - Laboratory and sampling and testing personnel qualifications.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... the FHWA. (3) After June 29, 2000, any non-STD designated laboratory which performs IA sampling and... testing data to be used in the acceptance decision or the IA program shall be executed by qualified... same project: Verification testing, quality control testing, IA testing, or dispute resolution testing....

  5. Communicating laboratory test results for rheumatoid factor: what do patients and physicians want?

    PubMed Central

    Kelman, Ariella; Robinson, Caroline O; Cochin, Elisenda; Ahluwalia, Nina J; Braverman, Julia; Chiauzzi, Emil; Simacek, Kristina

    2016-01-01

    Objective This study aimed to explore patient and physician perspectives on current laboratory test reporting practices and to elicit ideas for improvement. Methods Two independent studies were conducted. The first solicited members of an online physician community for opinions on current laboratory test reporting practices and possible improvements. The second addressed the same topic, but solicited patient feedback, and included an evaluation of a mock laboratory test report for the rheumatoid factor blood test. Results Both physicians and patients expressed a desire for patient-friendly information on laboratory reports. Physicians expressed a need for education for patients around false-positive and false-negative results within laboratory reports, while patients sought context around the meaning of results, relevance to other tests, and follow-up steps. Conclusion Physicians and patients see value in enhancing laboratory test reports to improve communication. While reports should include the context that patients value, they should also contain cautionary interpretation emphasized by physicians. Patient consultation on improving laboratory reports may help improve such patient-focused communication and promote greater patient understanding of health information, thereby increasing patient participation in their own health care and improving outcomes. Practice implications Laboratory reports are typically designed by experts. Including patients in laboratory report design may facilitate communication and improve outcomes through better patient engagement. PMID:28008236

  6. Automated cognitive testing of monkeys in social groups yields results comparable to individual laboratory-based testing.

    PubMed

    Gazes, Regina Paxton; Brown, Emily Kathryn; Basile, Benjamin M; Hampton, Robert R

    2013-05-01

    Cognitive abilities likely evolved in response to specific environmental and social challenges and are therefore expected to be specialized for the life history of each species. Specialized cognitive abilities may be most readily engaged under conditions that approximate the natural environment of the species being studied. While naturalistic environments might therefore have advantages over laboratory settings for cognitive research, it is difficult to conduct certain types of cognitive tests in these settings. We implemented methods for automated cognitive testing of monkeys (Macaca mulatta) in large social groups (Field station) and compared the performance to that of laboratory-housed monkeys (Laboratory). The Field station animals shared access to four touch-screen computers in a large naturalistic social group. Each Field station subject had an RFID chip implanted in each arm for computerized identification and individualized assignment of cognitive tests. The Laboratory group was housed and tested in a typical laboratory setting, with individual access to testing computers in their home cages. Monkeys in both groups voluntarily participated at their own pace for food rewards. We evaluated performance in two visual psychophysics tests, a perceptual classification test, a transitive inference test, and a delayed matching-to-sample memory test. Despite the differences in housing, social environment, age, and sex, monkeys in the two groups performed similarly in all tests. Semi-free ranging monkeys living in complex social environments are therefore viable subjects for cognitive testing designed to take advantage of the unique affordances of naturalistic testing environments.

  7. Tonopah test range - outpost of Sandia National Laboratories

    SciTech Connect

    Johnson, L.

    1996-03-01

    Tonopah Test Range is a unique historic site. Established in 1957 by Sandia Corporation, Tonopah Test Range in Nevada provided an isolated place for the Atomic Energy Commission to test ballistics and non-nuclear features of atomic weapons. It served this and allied purposes well for nearly forty years, contributing immeasurably to a peaceful conclusion to the long arms race remembered as the Cold War. This report is a brief review of historical highlights at Tonopah Test Range. Sandia`s Los Lunas, Salton Sea, Kauai, and Edgewood testing ranges also receive abridged mention. Although Sandia`s test ranges are the subject, the central focus is on the people who managed and operated the range. Comments from historical figures are interspersed through the narrative to establish this perspective, and at the end a few observations concerning the range`s future are provided.

  8. Testing general relativity in space-borne and astronomical laboratories

    NASA Technical Reports Server (NTRS)

    Will, Clifford M.

    1989-01-01

    The current status of space-based experiments and astronomical observations designed to test the theory of general relativity is surveyed. Consideration is given to tests of post-Newtonian gravity, searches for feeble short-range forces and gravitomagnetism, improved measurements of parameterized post-Newtonian parameter values, explorations of post-Newtonian physics, tests of the Einstein equivalence principle, observational tests of post-Newtonian orbital effects, and efforts to detect quadrupole and dipole radiation damping. Recent numerical results are presented in tables.

  9. The passive autocatalytic recombiner test program at Sandia National Laboratories

    SciTech Connect

    Blanchat, T.K.; Malliakos, A.

    1997-10-01

    Passive autocatalytic recombiners (PARs) are being considered by the nuclear power industry as a combustible gas control system in operating plants and advanced light water reactor (ALWR) containments for design basis events. Sandia National Laboratories (SNL) has developed systems and methodologies to measure the amount of hydrogen that can be depleted in a containment by a PAR. Experiments were performed that determined the hydrogen depletion rate of a PAR in the presence of steam and also evaluated the effect of scale (number of cartridges) on the PAR performance at both low and high hydrogen concentrations.

  10. IRAN: laboratory test bench for hypertelescope pupil-plane recombination

    NASA Astrophysics Data System (ADS)

    Allouche, F.; Vakili, F.; Glindemann, A.; Aristidi, E.; Abe, L.; Fossat, E.; Douet, R.

    2008-07-01

    In 2004, our group proposed IRAN, an alternative beam-combination technique to the so-called hypertelescope imaging method introduced by Labeyrie in the 1990s. We have recently set up a laboratory experiment aiming at validating our image densification approach instead of the pupil densification scheme of Labeyrie. In our experiment, seven sub-apertures illuminated by laser sources are recombined using the IRAN scheme. The validation of the IRAN recombination consists basically in retrieving the point-spread intensity distribution (PSID), demonstrating the conservation of the object-image convolution relation. We will introduce IRAN, compare it to the hyper-telescope, and present the experimental results that we obtained.

  11. [Ayurvedics drugs in France. Laboratories polytherapic, a test].

    PubMed

    Raynal, Cécile; Lefebvre, Thierry

    2011-02-01

    In the beginning of the thirties, Dr Jean Saidman, who has already created a rotative solarium at Aix-les-Bains, built another one in Jamnagar (India). When he was there, he discovered ayurvedic therapy. After the Second World War, with his friends Dr Rémus Krainik and the chemist René-Henri Monceaux, he set up a "néo-ayurvedic action committee", and then a pharmaceutical laboratory, "Polythérapic", to export to french colonies patents medicines inspired by indian medicine. The authors tale this experience suddenly stopped by the unexpected death of Jean Saidman, in 1949.

  12. Inter-laboratory variability in in vitro spinal segment flexibility testing.

    PubMed

    Wheeler, Daniel J; Freeman, Andrew L; Ellingson, Arin M; Nuckley, David J; Buckley, Jenni M; Scheer, Justin K; Crawford, Neil R; Bechtold, Joan E

    2011-09-02

    In vitro spine flexibility testing has been performed using a variety of laboratory-specific loading apparatuses and conditions, making test results across laboratories difficult to compare. The application of pure moments has been well established for spine flexibility testing, but to our knowledge there have been no attempts to quantify differences in range of motion (ROM) resulting from laboratory-specific loading apparatuses. Seven fresh-frozen lumbar cadaveric motion segments were tested intact at four independent laboratories. Unconstrained pure moments of 7.5 Nm were applied in each anatomic plane without an axial preload. At laboratories A and B, pure moments were applied using hydraulically actuated spinal loading fixtures with either a passive (A) or controlled (B) XY table. At laboratories C and D, pure moments were applied using a sliding (C) or fixed ring (D) cable-pulley system with a servohydraulic test frame. Three sinusoidal load-unload cycles were applied at laboratories A and B while a single quasistatic cycle was applied in 1.5 Nm increments at laboratories C and D. Non-contact motion measurement systems were used to quantify ROM. In all test directions, the ROM variability among donors was greater than single-donor ROM variability among laboratories. The maximum difference in average ROM between any two laboratories was 1.5° in flexion-extension, 1.3° in lateral bending and 1.1° in axial torsion. This was the first study to quantify ROM in a single group of spinal motion segments at four independent laboratories with varying pure moment systems. These data support our hypothesis that given a well-described test method, independent laboratories can produce similar biomechanical outcomes.

  13. Improved laboratory test selection and enhanced perception of test results as tools for cost-effective medicine.

    PubMed

    Mayer, M; Wilkinson, I; Heikkinen, R; Orntoft, T; Magid, E

    1998-09-01

    Inconsistencies in the way physicians perceive and handle identical laboratory results have untoward effects on morbidity, mortality and cost of medical care. In this context, the selection of suitable tests to answer definite clinical questions, and the manner in which laboratory results are presented have great impact on the action taken by the clinician. This review addresses preferred methods to improve laboratory test selection, and examines methods that more effectively convey laboratory results to clinicians. It is anticipated that refined selection of tests, and presentation of the test results in a configuration that is easily perceived by the clinician, will facilitate interpretation of laboratory reports. Furthermore, any measures that promote the application of laboratory information in medical practice improve economics at the laboratory-clinical interface. The presently described methods to optimize test selection and interpretation are: likelihood ratios to provide estimates of the ability of a test to identify a clinical condition; consensus- and discriminant function-analysis to estimate the performance of tests in diagnosing a particular disease or condition; receiver operating characteristic (ROC) curves to assess discrimination capabilities. The methods which improve test result perception are expression of results as multiples of the upper normal limit, utilizing signal strength to provide prognostic probabilities, and presentation of results in graphic forms that display mutually interrelated functions, with a specific cluster of results being highly suggestive of a given condition. In addition, we discuss application of expert systems to provide rules based on knowledge and experience to analyze results of tests and suggest diagnosis and action, including additional tests when required. It is anticipated that judicious utilization of laboratory services by application of the reviewed methodologies will help to achieve medically justified

  14. Avian Test Battery for the Evaluation of Developmental Abnormalities of Neuro- and Reproductive Systems.

    PubMed

    Kawashima, Takaharu; Ahmed, Walaa M S; Nagino, Koki; Ubuka, Takayoshi; Tsutsui, Kazuyoshi

    2016-01-01

    Most of the currently used toxicity assays for environmental chemicals use acute or chronic systemic or reproductive toxicity endpoints rather than neurobehavioral endpoints. In addition, the current standard approaches to assess reproductive toxicity are time-consuming. Therefore, with increasing numbers of chemicals being developed with potentially harmful neurobehavioral effects in higher vertebrates, including humans, more efficient means of assessing neuro- and reproductive toxicity are required. Here we discuss the use of a Galliformes-based avian test battery in which developmental toxicity is assessed by means of a combination of chemical exposure during early embryonic development using an embryo culture system followed by analyses after hatching of sociosexual behaviors such as aggression and mating and of visual memory via filial imprinting. This Galliformes-based avian test battery shows promise as a sophisticated means not only of assessing chemical toxicity in avian species but also of assessing the risks posed to higher vertebrates, including humans, which are markedly sensitive to nervous or neuroendocrine system dysfunction.

  15. Avian Test Battery for the Evaluation of Developmental Abnormalities of Neuro- and Reproductive Systems

    PubMed Central

    Kawashima, Takaharu; Ahmed, Walaa M. S.; Nagino, Koki; Ubuka, Takayoshi; Tsutsui, Kazuyoshi

    2016-01-01

    Most of the currently used toxicity assays for environmental chemicals use acute or chronic systemic or reproductive toxicity endpoints rather than neurobehavioral endpoints. In addition, the current standard approaches to assess reproductive toxicity are time-consuming. Therefore, with increasing numbers of chemicals being developed with potentially harmful neurobehavioral effects in higher vertebrates, including humans, more efficient means of assessing neuro- and reproductive toxicity are required. Here we discuss the use of a Galliformes-based avian test battery in which developmental toxicity is assessed by means of a combination of chemical exposure during early embryonic development using an embryo culture system followed by analyses after hatching of sociosexual behaviors such as aggression and mating and of visual memory via filial imprinting. This Galliformes-based avian test battery shows promise as a sophisticated means not only of assessing chemical toxicity in avian species but also of assessing the risks posed to higher vertebrates, including humans, which are markedly sensitive to nervous or neuroendocrine system dysfunction. PMID:27445667

  16. Performance of the platelet function analyser PFA-100 in testing abnormalities of primary haemostasis.

    PubMed

    Harrison, P; Robinson, M S; Mackie, I J; Joseph, J; McDonald, S J; Liesner, R; Savidge, G F; Pasi, J; Machin, S J

    1999-01-01

    The PFA-100 device is a new instrument for the in-vitro testing of platelet function. Primary haemostasis is stimulated by recording the closure time taken for platelets to seal a 150 microm aperture in the centre of a membrane coated with collagen and either epinephrine or ADP. Patients with type 3 von Willebrand's disease (n = 4) all had infinitely prolonged closure times (> 200 s) with both types of cartridge. A patient with afibrinogenemia exhibited only slightly prolonged closure times of 111 and 166 s for the ADP and epinephrine membranes, respectively. Patients with Glanzmann's thrombasthenia (n = 6) and Bernard Soulier syndrome (n = 2) had grossly prolonged closure times (> 200 s) with both types of cartridges. These results confirmed that the PFA-100 system was highly dependent on normal von Willebrand factor, glycoprotein Ib and glycoprotein IIb/IIIa levels but not on plasma fibrinogen. Patients with storage pool disease (n = 6) and Hermansky Pudlak syndrome (n = 7) had prolonged closure times with the epinephrine cartridge. There was no evidence of enhanced platelet function in patients with antiphospholipid syndrome, in sickle-cell disease or thalassemia. However, ingestion of aspirin resulted in a near consistent and significant prolongation of the closure time for the epinephrine cartridge but not for the ADP cartridge in both normal subjects and patients. The test offers a reliable, reproducible, rapid and simple means of assessing high-shear platelet function in vitro.

  17. Efficacy of inorganic compounds against soybean aphid, laboratory tests 2012

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Infestations by soybean aphids can reduce the yield of soybeans, and the efficacies of various compounds need evaluation for soybean aphid control. Efficacy of various inorganic compounds was compared to that of a water check and conventional insecticides in two growth-chamber tests. Soybean test ...

  18. PEP Support: Laboratory Scale Leaching and Permeate Stability Tests

    SciTech Connect

    Russell, Renee L.; Peterson, Reid A.; Rinehart, Donald E.; Buchmiller, William C.

    2010-05-21

    This report documents results from a variety of activities requested by the Hanford Tank Waste Treatment and Immobilization Plant (WTP). The activities related to caustic leaching, oxidative leaching, permeate precipitation behavior of waste as well as chromium (Cr) leaching are: • Model Input Boehmite Leaching Tests • Pretreatment Engineering Platform (PEP) Support Leaching Tests • PEP Parallel Leaching Tests • Precipitation Study Results • Cr Caustic and Oxidative Leaching Tests. Leaching test activities using the PEP simulant provided input to a boehmite dissolution model and determined the effect of temperature on mass loss during caustic leaching, the reaction rate constant for the boehmite dissolution, and the effect of aeration in enhancing the chromium dissolution during caustic leaching. Other tests were performed in parallel with the PEP tests to support the development of scaling factors for caustic and oxidative leaching. Another study determined if precipitate formed in the wash solution after the caustic leach in the PEP. Finally, the leaching characteristics of different chromium compounds under different conditions were examined to determine the best one to use in further testing.

  19. Synthesis and Testing of the Insecticide Carbaryl: A Laboratory Experiment.

    ERIC Educational Resources Information Center

    Thadeo, Peter F.; Mowery, Dwight F.

    1984-01-01

    Carbaryl, 1-naphthyl-N-methylcarbamate, is the biodegradable (soft) insecticide most commonly marketed by the Union Carbide Corporation under the trade name of Sevin. Procedures for the synthesis and testing of carbaryl and for the testing of some compounds similar to carbaryl are provided. Equations showing its synthesis from methyl isocyanate…

  20. Test Results From The Idaho National Laboratory 15kW High Temperature Electrolysis Test Facility

    SciTech Connect

    Carl M. Stoots; Keith G. Condie; James E. O'Brien; J. Stephen Herring; Joseph J. Hartvigsen

    2009-07-01

    A 15kW high temperature electrolysis test facility has been developed at the Idaho National Laboratory under the United States Department of Energy Nuclear Hydrogen Initiative. This facility is intended to study the technology readiness of using high temperature solid oxide cells for large scale nuclear powered hydrogen production. It is designed to address larger-scale issues such as thermal management (feed-stock heating, high temperature gas handling, heat recuperation), multiple-stack hot zone design, multiple-stack electrical configurations, etc. Heat recuperation and hydrogen recycle are incorporated into the design. The facility was operated for 1080 hours and successfully demonstrated the largest scale high temperature solid-oxide-based production of hydrogen to date.

  1. Assessments of Motor Abnormalities on the Grid-Walking and Foot-Fault Tests From Undernutrition in Wistar Rats.

    PubMed

    Horiquini Barbosa, Everton; Vallim, José Henrique; Lachat, João-José; de Castro, Vera Lucia S S

    2016-01-01

    This study was designed to verify whether different lactation conditions influenced nervous system development. The authors used motor tasks to verify changes in exploratory activity and muscle strength of weaned rats from different litter sizes and evaluated the applicability of the grid-walking test for assessing motor abnormalities caused by undernutrition. Alterations in litter size during the suckling period perturbed the nutritional status of pups, which exhibited body weight differences between the groups. Large-litter (L) pups showed significant delays in achieving developmental milestones and neurological reflexes compared to the small-litter (S) and medium-litter (M) pups. The S, M, and L group pups exhibited similar exploratory responses and muscle strength. In the grid-walking and foot-fault tests, the L group pups traveled shorter distances and, consequently, had less footsteps. However, the percentages of foot faults in the L group were higher than S and M groups. These results reflect delayed maturation of structures responsible for sensorimotor responses, such as the cerebellum, because much cerebellar maturation takes place postnatally. This is the first study to report that early undernutrition in pups resulted in suboptimal performances on the grid-walking and foot-fault tests and that the former test was sensitive to alterations caused by nutritional deficiency.

  2. Relationship of coagulation test abnormalities to tumour burden and postoperative DVT in resected colorectal cancer.

    PubMed

    Iversen, L H; Thorlacius-Ussing, O

    2002-03-01

    In a prospective study, coagulation test results were compared in 137 patients with colorectal cancer (CRC) and 39 subjects with benign colorectal diseases. Prothrombin fragment 1+2 (F1+2), thrombin-antithrombin complex (TAT), and soluble fibrin (SF) were measured in plasma before and after surgery. CRC patients presented with significantly higher values of F1+2 and TAT than controls. Patients with localised CRC had elevated values of F1+2 and TAT, whereas patients with advanced CRC also had elevated SF values. TAT and SF levels correlated with tumour spread, and normal values virtually excluded advanced cancer. Postoperative deep venous thrombosis (DVT) was diagnosed by phlebography in 20% of the CRC patients. Preoperative values of the markers did not predict postoperative DVT, but postoperative values did.

  3. Relationship between abnormal sperm morphology induced by dietary zinc deficiency and lipid composition in testes of growing rats.

    PubMed

    Merrells, Krystal J; Blewett, Heather; Jamieson, Jennifer A; Taylor, Carla G; Suh, Miyoung

    2009-07-01

    The present study investigated the effect of dietary Zn deficiency during sexual maturation on sperm integrity and testis phospholipid fatty acid composition. Male weanling Sprague-Dawley rats were randomised into four dietary groups for 3 weeks: Zn control (ZC; 30 mg Zn/kg); Zn marginally deficient (ZMD; 9 mg Zn/kg); Zn deficient (ZD; < 1 mg Zn/kg); pair fed (PF; 30 mg Zn/kg) to the ZD group. Morphology of cauda epididymal sperm and lipid profiles of testis phospholipids were analysed. The rats fed the ZD diet had a lower testis weight (P < 0.02). Seminal vesicles and prostate weight were also lower in the ZD and PF groups. Rats fed the ZD diet, but not the ZMD diet, had 34-35 % more abnormal spermatozoa and 24 % shorter sperm tail length than the ZC and PF rats (P < 0.001). Testis cholesterol concentration was higher in the ZD rats compared with the ZC and PF rats (P < 0.04). Testes were highly enriched with n-6 fatty acids by showing n-6 : n-3 fatty acid ratios of 27:1 in phosphatidylcholine (PC) and 23:1 in phosphatidylethanolamine (PE). The dominant fatty acid in testes was docosapentaenoic acid (22 : 5n-6), comprising 15 and 24 % of PC and PE, respectively. This fatty acid was significantly lower in the ZD rats, whereas 18 : 2n-6 was higher compared with the rats in the other diet groups. These results demonstrate that severe Zn deficiency adversely affects sperm integrity and modulates testis fatty acid composition by interrupting essential fatty acid metabolism. This suggests that Zn deficiency-associated abnormal testicular function is perhaps preceded by altered membrane fatty acid composition, especially of a major fatty acid, 22 : 5n-6.

  4. Cognitive and Neuropsychological Test Performance of Persons with Abnormalities of Adolescent Development: A Test of Waber's Hypothesis.

    ERIC Educational Resources Information Center

    Rovet, Joanne

    1983-01-01

    A total of 20 children with idiopathic precocious puberty; 27 adolescents with clinically delayed puberty; and an equivalent number of controls matched for sex, age, and IQ were given a battery of tests including measures of verbal and spatial abilities and a task using a dichotic listening procedure to assess hemispheric lateralization.…

  5. DESCRIPTION OF RISK REDUCTION ENGINEERING LABORATORY TEST AND EVALUATION FACILITIES

    EPA Science Inventory

    An onsite team of multidisciplined engineers and scientists conduct research and provide technical services in the areas of testing, design, and field implementation for both solid and hazardous waste management. Engineering services focus on the design and implementation of...

  6. Alveolar abnormalities

    MedlinePlus

    ... page: //medlineplus.gov/ency/article/001093.htm Alveolar abnormalities To use the sharing features on this page, please enable JavaScript. Alveolar abnormalities are changes in the tiny air sacs in ...

  7. Nail abnormalities

    MedlinePlus

    Beau's lines; Fingernail abnormalities; Spoon nails; Onycholysis; Leukonychia; Koilonychia; Brittle nails ... 2012:chap 71. Zaiac MN, Walker A. Nail abnormalities associated with systemic pathologies. Clin Dermatol . 2013;31: ...

  8. Laboratory test of Newton's second law for small accelerations.

    PubMed

    Gundlach, J H; Schlamminger, S; Spitzer, C D; Choi, K-Y; Woodahl, B A; Coy, J J; Fischbach, E

    2007-04-13

    We have tested the proportionality of force and acceleration in Newton's second law, F=ma, in the limit of small forces and accelerations. Our tests reach well below the acceleration scales relevant to understanding several current astrophysical puzzles such as the flatness of galactic rotation curves, the Pioneer anomaly, and the Hubble acceleration. We find good agreement with Newton's second law at accelerations as small as 5 x 10(-14) m/s(2).

  9. Laboratory Test of Newton's Second Law for Small Accelerations

    SciTech Connect

    Gundlach, J. H.; Schlamminger, S.; Spitzer, C. D.; Choi, K.-Y.; Woodahl, B. A.; Coy, J. J.; Fischbach, E.

    2007-04-13

    We have tested the proportionality of force and acceleration in Newton's second law, F=ma, in the limit of small forces and accelerations. Our tests reach well below the acceleration scales relevant to understanding several current astrophysical puzzles such as the flatness of galactic rotation curves, the Pioneer anomaly, and the Hubble acceleration. We find good agreement with Newton's second law at accelerations as small as 5x10{sup -14} m/s{sup 2}.

  10. Laboratory Test of Newton's Second Law for Small Accelerations

    NASA Astrophysics Data System (ADS)

    Woodahl, Brian; Gundlach, Jens; Schlamminger, Stephan; Spitzer, Chris; Choi, Ki; Coy, Jen; Fischbach, Ephraim

    2009-10-01

    We have tested the proportionality of force and acceleration in Newton's second law, F=ma, in the limit of small forces and accelerations. Our tests reach well below the acceleration scales relevant to understanding several current astrophysical puzzles such as the flatness of galactic rotation curves, the Pioneer anomaly, and the Hubble acceleration. We find good agreement with Newton's second law at accelerations as small as 5 x 10-14 m/s^2.

  11. Laboratory Test of Newton's Second Law for Small Accelerations

    NASA Astrophysics Data System (ADS)

    Gundlach, J. H.; Schlamminger, S.; Spitzer, C. D.; Choi, K.-Y.; Woodahl, B. A.; Coy, J. J.; Fischbach, E.

    2007-04-01

    We have tested the proportionality of force and acceleration in Newton’s second law, F=ma, in the limit of small forces and accelerations. Our tests reach well below the acceleration scales relevant to understanding several current astrophysical puzzles such as the flatness of galactic rotation curves, the Pioneer anomaly, and the Hubble acceleration. We find good agreement with Newton’s second law at accelerations as small as 5×10-14m/s2.

  12. Evaluation of a decision aid for prenatal testing of fetal abnormalities: a cluster randomised trial [ISRCTN22532458

    PubMed Central

    Nagle, Cate; Lewis, Sharon; Meiser, Bettina; Metcalfe, Sylvia; Carlin, John B; Bell, Robin; Gunn, Jane; Halliday, Jane

    2006-01-01

    Background By providing information on the relative merits and potential harms of the options available and a framework to clarify preferences, decision aids can improve knowledge and realistic expectations and decrease decisional conflict in individuals facing decisions between alternative forms of action. Decision-making about prenatal testing for fetal abnormalities is often confusing and difficult for women and the effectiveness of decision aids in this field has not been established. This study aims to test whether a decision aid for prenatal testing of fetal abnormalities, when compared to a pamphlet, improves women's informed decision-making and decreases decisional conflict. Methods/design A cluster designed randomised controlled trial is being conducted in Victoria, Australia. Fifty General Practitioners (GPs) have been randomised to one of two arms: providing women with either a decision aid or a pamphlet. The two primary outcomes will be measured by comparing the difference in percentages of women identified as making an informed choice and the difference in mean decisional conflict scores between the two groups. Data will be collected from women using questionnaires at 14 weeks and 24 weeks gestation. The sample size of 159 women in both arms of the trial has been calculated to detect a difference of 18% (50 to 68%) in informed choice between the two groups. The required numbers have been adjusted to accommodate the cluster design, miscarriage and participant lost – to – follow up. Baseline characteristics of women will be summarised for both arms of the trial. Similarly, characteristics of GPs will be compared between arms. Differences in the primary outcomes will be analysed using 'intention-to-treat' principles. Appropriate regression techniques will adjust for the effects of clustering and include covariates to adjust for the stratifying variable and major potential confounding factors. Discussion The findings from this trial will make a

  13. Real-time laboratory exercises to test contingency plans for classical swine fever: experiences from two national laboratories.

    PubMed

    Koenen, F; Uttenthal, A; Meindl-Böhmer, A

    2007-12-01

    In order to adequately and efficiently handle outbreaks of contagious diseases such as classical swine fever (CSF), foot and mouth disease or highly pathogenic avian influenza, competent authorities and the laboratories involved have to be well prepared and must be in possession of functioning contingency plans. These plans should ensure that in the event of an outbreak access to facilities, equipment, resources, trained personnel, and all other facilities needed for the rapid and efficient eradication of the outbreak is guaranteed, and that the procedures to follow are well rehearsed. It is essential that these plans are established during 'peace-time' and are reviewed regularly. This paper provides suggestions on how to perform laboratory exercises to test preparedness and describes the experiences of two national reference laboratories for CSF. The major lesson learnt was the importance of a well-documented laboratory contingency plan. The major pitfalls encountered were shortage of space, difficulties in guaranteeing biosecurity and sufficient supplies of sterile equipment and consumables. The need for a standardised laboratory information management system, that is used by all those involved in order to reduce the administrative load, is also discussed.

  14. Laboratory testing of a flexible boom for ice management

    SciTech Connect

    Loeset, S. . Norwegian Hydrotechnical Lab.); Timco, G.W. )

    1993-08-01

    Combating oil spills in the Arctic is a major challenge. Drilling or producing oil or gas in the marginal ice zone (MIZ) may allow booms to be deployed upstream of an offshore structure to clear the water of ice, thereby enabling conventional oil spill countermeasures to be used. Such a boom would be kept in place by two ice-going service vessels or by moored buoys. SINTEF NHL and NRC have performed a number of small-scale tests with a flexible boom in the NRC ice basin in Ottawa. The purpose of the tests was to measure the effectiveness of using a flexible boom for collecting ice, and to determine the loads associated with collecting the ice. In the tests, various boom configurations were towed against a broken ice field consisting of ice pieces typically 50--100 mm across and 30 mm thick. The ice concentration was usually 10/10, but it was reduced to 8/10 and 5/10 for two tests. The boom was towed at speeds of 20 and 50 mm-s[sup [minus]1]. Both the width of the boom and the slackness of the boom were varied over reasonable ranges. Two six-component dynamometers were used to support the boom. Thus, the force components on each end of the boom were measured. Further, two video cameras were used to record the effectiveness of each boom configuration. In this paper, the full results of this test program are presented and the application of the test results to the full-scale situation are discussed. The tests show that, under certain conditions, the use of boom is feasible for ice management in oil-contaminated water.

  15. ESO adaptive optics facility progress and first laboratory test results

    NASA Astrophysics Data System (ADS)

    Arsenault, Robin; Madec, Pierre-Yves; Paufique, Jérome; La Penna, Paolo; Stroebele, Stefan; Vernet, Elise; Pirard, Jean-Francois; Hackenberg, Wolfgang; Kuntschner, Harald; Kolb, Johann; Muller, Nicolas; Garcia-Rissmann, Aurea; Le Louarn, Miska; Amico, Paola; Hubin, Norbert; Lizon, Jean-Louis; Ridings, Rob; Haguenauer, Pierre; Abad, Jose A.; Fischer, Gerhard; Heinz, Volker; Kiekebusch, Mario; Argomedo, Javier; Conzelmann, Ralf; Tordo, Sebastien; Donaldson, Rob; Soenke, Christian; Duhoux, Philippe; Fedrigo, Enrico; Delabre, Bernard; Jost, Andrea; Duchateau, Michel; Downing, Mark; Reyes Moreno, Javier; Manescau, Antonio; Bonaccini Calia, Domenico; Quattri, Marco; Dupuy, Christophe; Guidolin, Ivan M.; Comin, Mauro; Guzman, Ronald; Buzzoni, Bernard; Quentin, Jutta; Lewis, Steffan; Jolley, Paul; Kraus, Max; Pfrommer, Thomas; Biasi, Roberto; Gallieni, Daniele; Stuik, Remko; Kaenders, Wilhelm; Ernstberger, Bernhard; Friedenauer, Axel

    2014-07-01

    The Adaptive Optics Facility project is completing the integration of its systems at ESO Headquarters in Garching. The main test bench ASSIST and the 2nd Generation M2-Unit (hosting the Deformable Secondary Mirror) have been granted acceptance late 2012. The DSM has undergone a series of tests on ASSIST in 2013 which have validated its optical performance and launched the System Test Phase of the AOF. This has been followed by the performance evaluation of the GRAAL natural guide star mode on-axis and will continue in 2014 with its Ground Layer AO mode. The GALACSI module (for MUSE) Wide-Field-Mode (GLAO) and the more challenging Narrow-Field-Mode (LTAO) will then be tested. The AOF has also taken delivery of the second scientific thin shell mirror and the first 22 Watt Sodium laser Unit. We will report on the system tests status, the performances evaluated on the ASSIST bench and advancement of the 4Laser Guide Star Facility. We will also present the near future plans for commissioning on the telescope and some considerations on tools to ensure an efficient operation of the Facility in Paranal.

  16. Seed dressing pesticides on springtails in two ecotoxicological laboratory tests.

    PubMed

    Alves, Paulo Roger L; Cardoso, Elke J B N; Martines, Alexandre M; Sousa, José Paulo; Pasini, Amarildo

    2014-07-01

    Terrestrial ecotoxicological tests are powerful tools for assessing the ecological risks that pesticides pose to soil invertebrates, but they are rarely used to evaluate seed dressing pesticides. This study investigated the effects of seed dressing pesticides on survival and reproduction of Folsomia candida (Collembola), using standardized ecotoxicological tests (after ISO guidelines with few adaptations for tropical conditions). Commercial formulations of five seed dressing pesticides were tested individually in Tropical Artificial Soil (TAS): the insecticides imidacloprid, fipronil, thiametoxam, and the fungicides captan and carboxin+thiram. Thiametoxam, captan, and carboxin+thiram were only lethal to F. candida at the highest concentration tested (1000mg of active ingredient kg(-1) of dry soil). Imidacloprid and fipronil were lethal at lower concentrations (100 and 10mg a.i. kg(-1) soil d.w, respectively), however, these concentrations were much higher than those predicted (PEC) for soil. Imidacloprid and fipronil were the most toxic pesticides in both tests, reducing significantly collembolan reproduction (EC20=0.02 and 0.12mga.i.kg(-1) soil d.w, respectively). Further studies under more realistic conditions are needed, since imidacloprid and fipronil reduced collembolan reproduction at concentrations below or close to their respective PECs.

  17. 19 CFR 151.73 - Importer's request for commercial laboratory test.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... Hair § 151.73 Importer's request for commercial laboratory test. (a) Conditions for commercial test. If... request that a commercial test be made to determine the percentage clean yield of the wool or hair. (b... the wool or hair in dispute to be selected and tested by a commercial method approved by...

  18. 19 CFR 151.73 - Importer's request for commercial laboratory test.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... Hair § 151.73 Importer's request for commercial laboratory test. (a) Conditions for commercial test. If... request that a commercial test be made to determine the percentage clean yield of the wool or hair. (b... the wool or hair in dispute to be selected and tested by a commercial method approved by...

  19. 19 CFR 151.73 - Importer's request for commercial laboratory test.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... Hair § 151.73 Importer's request for commercial laboratory test. (a) Conditions for commercial test. If... request that a commercial test be made to determine the percentage clean yield of the wool or hair. (b... the wool or hair in dispute to be selected and tested by a commercial method approved by...

  20. 19 CFR 151.73 - Importer's request for commercial laboratory test.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Hair § 151.73 Importer's request for commercial laboratory test. (a) Conditions for commercial test. If... request that a commercial test be made to determine the percentage clean yield of the wool or hair. (b... the wool or hair in dispute to be selected and tested by a commercial method approved by...

  1. 19 CFR 151.73 - Importer's request for commercial laboratory test.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Hair § 151.73 Importer's request for commercial laboratory test. (a) Conditions for commercial test. If... request that a commercial test be made to determine the percentage clean yield of the wool or hair. (b... the wool or hair in dispute to be selected and tested by a commercial method approved by...

  2. 49 CFR 40.99 - How long does the laboratory retain specimens after testing?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... FOR TRANSPORTATION WORKPLACE DRUG AND ALCOHOL TESTING PROGRAMS Drug Testing Laboratories § 40.99 How... time (e.g., for the purpose of preserving evidence for litigation or a safety investigation). If you... testing, you must retain the split specimen for an employee's test for the same period of time that...

  3. Flood-Fighting Structures Demonstration and Evaluation Program: Laboratory and Field Testing in Vicksburg, Mississippi

    DTIC Science & Technology

    2007-07-01

    Laboratory and Field Testing in Vicksburg, Mississippi Fred Pinkard, Thad Pratt, Donald Ward Tina Holmes, Julie Kelley, Landris T. Lee, George Sills...July 2007 Flood-Fighting Structures Demonstration and Evaluation Program: Laboratory and Field Testing in Vicksburg, Mississippi Fred Pinkard, Thad...real-world testing procedures for Rapid De- ployment Flood Wall (RDFW) and other promising alternative flood-fighting technologies. In response to

  4. Laboratory testing of sealants with a marble substrate

    SciTech Connect

    Farmer, M.C.; Cechner, R.A.

    1996-12-31

    Polyurethane and silicone sealants are widely specified for installations with porous substrates such as some stones. However, when a sealant is used against such surfaces, there is a potential for a lack of adequate adhesion, or staining of the tone by misapplication or migration of the liquid components of the sealant system, such as primers or plasticizers in the formulation. Some varieties of marble in particular have been reported to be susceptible to staining and discoloration over time from sealants. Application of new sealant over existing sealants is also of great concern for remedial applications. Determining the level of substrate preparation necessary to achieve adequate bond is critical to the success of the remedial construction project. This paper discusses the development and results of a test program conducted to determine the relative performance of sealants installed on a white marble substrate. The tests performed included wet adhesion tests, accelerated weathering studies, and staining due to plasticizer migration.

  5. 9 CFR 54.11 - Approval of laboratories to run official scrapie tests and official genotype tests.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... approved by NVSL; (2) Has adequate facilities and equipment to conduct the test; (3) Follows standard test protocols; (4) Meets check test proficiency requirements; (5) Meets recordkeeping requirements; (6) Will... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Approval of laboratories to...

  6. Determination of HART I Blade Structural Properties by Laboratory Testing

    NASA Technical Reports Server (NTRS)

    Jung, Sung N.; Lau, Benton H.

    2012-01-01

    The structural properties of higher harmonic Aeroacoustic Rotor Test (HART I) blades were measured using the original set of blades tested in the German-dutch wind tunnel (DNW) in 1994. the measurements include bending and torsion stiffness, geometric offsets, and mass and inertia properties of the blade. the measured properties were compared to the estimated values obtained initially from the blade manufacturer. The previously estimated blade properties showed consistently higher stiffness, up to 30 percent for the flap bending in the blade inboard root section.

  7. Laboratory Test of Newton's Second Law for Small Accelerations

    NASA Astrophysics Data System (ADS)

    Woodahl, Brian; Gundlach, Jens; Schlamminger, Stephan; Spitzer, Chris; Choi, Ki; Coy, Jennifer; Fischbach, Ephraim

    2007-05-01

    We have tested the proportionality of force and acceleration in Newton's second law, F=ma, in the limit of small forces and accelerations. Our tests reach well below the acceleration scales relevant to understanding several current astrophysical puzzles such as the flatness of galactic rotation curves, the Pioneer anomaly, and the Hubble acceleration. We find good agreement with Newton's second law at accelerations as small as 5 x 10-14 m/s^2. To cite this abstract, use the following reference: http://meetings.aps.org/link/BAPS.2007.OSS07.P1.15

  8. Infectious titres of sheep scrapie and bovine spongiform encephalopathy agents cannot be accurately predicted from quantitative laboratory test results.

    PubMed

    González, Lorenzo; Thorne, Leigh; Jeffrey, Martin; Martin, Stuart; Spiropoulos, John; Beck, Katy E; Lockey, Richard W; Vickery, Christopher M; Holder, Thomas; Terry, Linda

    2012-11-01

    It is widely accepted that abnormal forms of the prion protein (PrP) are the best surrogate marker for the infectious agent of prion diseases and, in practice, the detection of such disease-associated (PrP(d)) and/or protease-resistant (PrP(res)) forms of PrP is the cornerstone of diagnosis and surveillance of the transmissible spongiform encephalopathies (TSEs). Nevertheless, some studies question the consistent association between infectivity and abnormal PrP detection. To address this discrepancy, 11 brain samples of sheep affected with natural scrapie or experimental bovine spongiform encephalopathy were selected on the basis of the magnitude and predominant types of PrP(d) accumulation, as shown by immunohistochemical (IHC) examination; contra-lateral hemi-brain samples were inoculated at three different dilutions into transgenic mice overexpressing ovine PrP and were also subjected to quantitative analysis by three biochemical tests (BCTs). Six samples gave 'low' infectious titres (10⁶·⁵ to 10⁶·⁷ LD₅₀ g⁻¹) and five gave 'high titres' (10⁸·¹ to ≥ 10⁸·⁷ LD₅₀ g⁻¹) and, with the exception of the Western blot analysis, those two groups tended to correspond with samples with lower PrP(d)/PrP(res) results by IHC/BCTs. However, no statistical association could be confirmed due to high individual sample variability. It is concluded that although detection of abnormal forms of PrP by laboratory methods remains useful to confirm TSE infection, infectivity titres cannot be predicted from quantitative test results, at least for the TSE sources and host PRNP genotypes used in this study. Furthermore, the near inverse correlation between infectious titres and Western blot results (high protease pre-treatment) argues for a dissociation between infectivity and PrP(res).

  9. Laboratory model of gas microchromatograph: construction and testing

    NASA Astrophysics Data System (ADS)

    Mroz, Jerzy; Szczygielska, Malgorzata; Dziuban, Jan; Gorecka-Drzazga, Anna

    2001-08-01

    The paper describes the microsystems for total chemical analysis and the structure of a gas microchromatograph. The construction and technical data of capillary micro column of thermo conducting detector and gas microvalve are also described. The paper refers to the test of a model of gas micro chromatography, the analyses of gas samples and presents the exemplary chromatograms.

  10. Evolution of a Computer-Based Testing Laboratory

    ERIC Educational Resources Information Center

    Moskal, Patrick; Caldwell, Richard; Ellis, Taylor

    2009-01-01

    In 2003, faced with increasing growth in technology-based and large-enrollment courses, the College of Business Administration at the University of Central Florida opened a computer-based testing lab to facilitate administration of course examinations. Patrick Moskal, Richard Caldwell, and Taylor Ellis describe the development and evolution of the…

  11. En route noise annoyance laboratory test: Preliminary results

    NASA Technical Reports Server (NTRS)

    Mccurdy, David A.

    1990-01-01

    Until recently concerns about the impact of aircraft noise on people have centered around the takeoff and landing operations of aircraft in the vicinity of airport terminals. The development of the advanced turboprop (propfan) engine, modifications to air corridors, and the desire to maintain a natural environment in national parks and recreation areas have now focused attention on the impact at ground level of the en route noise produced by aircraft at cruise conditions and altitudes. Compared to terminal area noise, en route noise is characterized by relatively low noise levels, lack of high frequency spectral content, and long durations. Much research has been directed towards understanding and quantifying the annoyance caused by terminal area aircraft noise, but relatively little research has been conducted for en route noise. To address this need, a laboratory experiment was conducted to quantify the annoyance of people on the ground to en route noise generated by aircraft at cruise conditions. The objectives of the experiment are to determine the annoyance prediction ability of noise measurement procedures and corrections when applied to en route noise; to determine differences in annoyance response to en route noise and takeoff/landing noise; and to determine differences in annoyance response to advanced turboprop en route noise and conventional jet en route noise.

  12. Crime laboratory proficiency testing results, 1978-1991, II: Resolving questions of common origin.

    PubMed

    Peterson, J L; Markham, P N

    1995-11-01

    A preceding article has examined the origins of crime laboratory proficiency testing and the performance of laboratories in the identification and classification of common types of physical evidence. Part II reviews laboratory proficiency in determining if two or more evidence samples shared a common source. Parts I and II together review the results of 175 separate tests issued to crime laboratories over the period 1978 to 1991. Laboratories perform best in determining the origin of finger and palm prints, metals, firearms (bullets and catridge cases), and footwear. Laboratories have moderate success in determining the source of bloodstains, questioned documents, toolmarks, and hair. A final category is of greater concern and includes those evidence categories where 10% or more of results disagree with manufacturers regarding the source of samples. This latter group includes paint, glass, fibers, and body fluid mixtures. The article concludes with a comparison of current findings with earlier LEAA study results, and a discussion of judicial and policy implications.

  13. A French Approach to Test Fetuses with Ultrasound Abnormalities Using a Customized Microarray as First-Tier Genetic Test.

    PubMed

    Malan, Valérie; Lapierre, Jean-Michel; Egloff, Matthieu; Goidin, Didier; Beaujard, Marie-Paule; Maurin, Marie-Laure; Attié-Bitach, Tania; Bessières, Bettina; Bernard, Jean-Pierre; Roth, Philippe; Stirnemann, Julien; Salomon, Laurent; Romana, Serge; Vekemans, Michel; Ville, Yves; Turleau, Catherine

    2015-01-01

    Cytogenetic microarray analysis is now the first-tier genetic test used in a postnatal clinical setting to explore genomic imbalances in individuals with developmental disability and/or birth defects. However, in a prenatal setting, this technique is not widely implemented, largely because the clinical impact of some copy number variants (CNVs) remains difficult to assess. This limitation is especially true in France where termination of pregnancy for medical reasons may be performed at any stage of gestation. During a period of 15 months, we investigated 382 fetuses presenting with ultrasound anomalies, using a customized microarray designed to avoid the detection of CNVs raising challenges for genetic counseling. After excluding common aneuploidies, 20/374 (5.3%) fetuses had a pathogenic CNV, among which 12/374 (3.2%) could have been detected by karyotyping, whereas 8/374 (2.1%) were cryptic. Within these 374 cases, 300 were ongoing pregnancies at the time of array comparative genomic hybridization (aCGH) testing. For these pregnancies, we detected 18/300 (6%) pathogenic CNVs, among which 6/300 (2%) were cryptic. Using this approach, only 2/300 (0.6%) of the detected CNVs raised difficulties for genetic counseling. This study confirms the added value of this strategy in a prenatal clinical setting to minimize ethical issues for genetic counseling while enhancing the detection of genomic imbalances.

  14. ChemCam for Mars Science Laboratory rover, undergoing pre-flight testing

    ScienceCinema

    None

    2016-07-12

    Los Alamos National Laboratory and partners developed a laser instrument, ChemCam, that will ride on the elevated mast of the Mars Science Laboratory rover Curiosity. The system allows Curiosity to "zap" rocks from a distance, reading their chemical composition through spectroscopic analysis. In this video, laboratory shaker-table testing of the instrument ensures that all of its components are solidly attached and resistant to damage from the rigors of launch, travel and landing.

  15. ChemCam for Mars Science Laboratory rover, undergoing pre-flight testing

    SciTech Connect

    2011-10-20

    Los Alamos National Laboratory and partners developed a laser instrument, ChemCam, that will ride on the elevated mast of the Mars Science Laboratory rover Curiosity. The system allows Curiosity to "zap" rocks from a distance, reading their chemical composition through spectroscopic analysis. In this video, laboratory shaker-table testing of the instrument ensures that all of its components are solidly attached and resistant to damage from the rigors of launch, travel and landing.

  16. [Approval of ISO/IEC 17025 and quality control of laboratory testing].

    PubMed

    Yamamoto, Shigeki; Asakura, Hiroshi; Machii, Kenji; Igimi, Shizunobu

    2010-01-01

    First section of Division of Biomedical Food Research, National Institute of Health Sciences (NIHS) was approved by ISO/IEC 17025 as a laboratory having an appropriate laboratory testing technique. NIHS is the first national laboratory approved by ISO/IEC 17025. NIHS has also been accepted the appropriate technique and facility for the BSL3 level pathogens by ISO/IEC 17025. NIHS is necessary to take an external audit almost every year. This approval is renewed every 4 years.

  17. Identifying the Clinical Laboratory Tests from Unspecified “Other Lab Test” Data for Secondary Use

    PubMed Central

    Pan, Xuequn; Cimino, James J.

    2015-01-01

    Clinical laboratory results are stored in electronic health records (EHRs) as structured data coded with local or standard terms. However, laboratory tests that are performed at outside laboratories are often simply labeled “outside test” or something similar, with the actual test name in a free-text result or comment field. After being aggregated into clinical data repositories, these ambiguous labels impede the retrieval of specific test results. We present a general multi-step solution that can facilitate the identification, standardization, reconciliation, and transformation of such test results. We applied our approach to data in the NIH Biomedical Translational Research Information System (BTRIS) to identify laboratory tests, map comment values to the LOINC codes that will be incorporated into our Research Entities Dictionary (RED), and develop a reference table that can be used in the EHR data extract-transform-load (ETL) process. PMID:26958239

  18. 6. Exterior view of Components Test Laboratory (T27), looking southwest. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. Exterior view of Components Test Laboratory (T-27), looking southwest. The building wing on the left houses Test Cell 9 (fuel), and that on the right houses the equipment room. The corrugated aluminum shed that is taller than the main building in the left foreground houses a citric acid air pollution control room (also known as scrubber room), the interior of which may be seen in CO-88-A-21. - Air Force Plant PJKS, Systems Integration Laboratory, Components Test Laboratory, Waterton Canyon Road & Colorado Highway 121, Lakewood, Jefferson County, CO

  19. EVA Development and Verification Testing at NASA's Neutral Buoyancy Laboratory

    NASA Technical Reports Server (NTRS)

    Jairala, Juniper; Durkin, Robert

    2012-01-01

    As an early step in preparing for future EVAs, astronauts perform neutral buoyancy testing to develop and verify EVA hardware and operations. To date, neutral buoyancy demonstrations at NASA JSC’s Sonny Carter Training Facility have primarily evaluated assembly and maintenance tasks associated with several elements of the ISS. With the retirement of the Space Shuttle, completion of ISS assembly, and introduction of commercial participants for human transportation into space, evaluations at the NBL will take on a new focus. In this session, Juniper Jairala briefly discussed the design of the NBL and, in more detail, described the requirements and process for performing a neutral buoyancy test, including typical hardware and support equipment requirements, personnel and administrative resource requirements, examples of ISS systems and operations that are evaluated, and typical operational objectives that are evaluated. Robert Durkin discussed the new and potential types of uses for the NBL, including those by non-NASA external customers.

  20. NREL Highlight: Truck Platooning Testing; NREL (National Renewable Energy Laboratory)

    SciTech Connect

    2015-05-21

    NREL's fleet test and evaluation team assesses the fuel savings potential of semi-automated truck platooning of line-haul sleeper cabs with modern aerodynamics. Platooning reduces aerodynamic drag by grouping vehicles together and safely decreasing the distance between them via electronic coupling, which allows multiple vehicles to accelerate or brake simultaneously. In 2014, the team conducted track testing of three SmartWay tractor - two platooned tractors and one control tractor—at varying steady-state speeds, following distances, and gross vehicle weights. While platooning improved fuel economy at all speeds, travel at 55 mph resulted in the best overall miles per gallon. The lead truck demonstrated fuel savings up to 5.3% while the trailing truck saved up to 9.7%. A number of conditions impact the savings attainable, including ambient temperature, distance between lead and trailing truck, and payload weight. Future studies may look at ways to optimize system fuel efficiency and emissions reductions.