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Sample records for abnormally high number

  1. High frequency of known copy number abnormalities and maternal duplication 15q11-q13 in patients with combined schizophrenia and epilepsy

    PubMed Central

    2011-01-01

    Background Many copy number variants (CNVs) are documented to be associated with neuropsychiatric disorders, including intellectual disability, autism, epilepsy, schizophrenia, and bipolar disorder. Chromosomal deletions of 1q21.1, 3q29, 15q13.3, 22q11.2, and NRXN1 and duplications of 15q11-q13 (maternal), 16p11, and 16p13.3 have the strongest association with schizophrenia. We hypothesized that cases with both schizophrenia and epilepsy would have a higher frequency of disease-associated CNVs and would represent an enriched sample for detection of other mutations associated with schizophrenia. Methods We used array comparative genomic hybridization (CGH) to analyze 235 individuals with both schizophrenia and epilepsy, 80 with bipolar disorder and epilepsy, and 191 controls. Results We detected 10 schizophrenia plus epilepsy cases in 235 (4.3%) with the above mentioned CNVs compared to 0 in 191 controls (p = 0.003). Other likely pathological findings in schizophrenia plus epilepsy cases included 1 deletion 16p13 and 1 duplication 7q11.23 for a total of 12/235 (5.1%) while a possibly pathogenic duplication of 22q11.2 was found in one control for a total of 1 in 191 (0.5%) controls (p = 0.008). The rate of abnormality in the schizophrenia plus epilepsy of 10/235 for the more definite CNVs compares to a rate of 75/7336 for these same CNVs in a series of unselected schizophrenia cases (p = 0.0004). Conclusion We found a statistically significant increase in the frequency of CNVs known or likely to be associated with schizophrenia in individuals with both schizophrenia and epilepsy compared to controls. We found an overall 5.1% detection rate of likely pathological findings which is the highest frequency of such findings in a series of schizophrenia patients to date. This evidence suggests that the frequency of disease-associated CNVs in patients with both schizophrenia and epilepsy is significantly higher than for unselected schizophrenia. PMID:22118685

  2. High Reynolds Number Research

    NASA Technical Reports Server (NTRS)

    Baals, D. D. (Editor)

    1977-01-01

    Fundamental aerodynamic questions for which high Reynolds number experimental capability is required are discussed. The operational characteristics and design features of the National Transonic Facility are reviewed.

  3. Abnormally high formation pressures, Potwar Plateau, Pakistan

    USGS Publications Warehouse

    Law, B.E.; Shah, S.H.A.; Malik, M.A.

    1998-01-01

    Abnormally high formation pressures in the Potwar Plateau of north-central Pakistan are major obstacles to oil and gas exploration. Severe drilling problems associated with high pressures have, in some cases, prevented adequate evaluation of reservoirs and significantly increased drilling costs. Previous investigations of abnormal pressure in the Potwar Plateau have only identified abnormal pressures in Neogene rocks. We have identified two distinct pressure regimes in this Himalayan foreland fold and thrust belt basin: one in Neogene rocks and another in pre-Neogene rocks. Pore pressures in Neogene rocks are as high as lithostatic and are interpreted to be due to tectonic compression and compaction disequilibrium associated with high rates of sedimentation. Pore pressure gradients in pre-Neogene rocks are generally less than those in Neogene rocks, commonly ranging from 0.5 to 0.7 psi/ft (11.3 to 15.8 kPa/m) and are most likely due to a combination of tectonic compression and hydrocarbon generation. The top of abnormally high pressure is highly variable and doesn't appear to be related to any specific lithologic seal. Consequently, attempts to predict the depth to the top of overpressure prior to drilling are precluded.

  4. Abnormal high density lipoproteins in cerebrotendinous xanthomatosis

    SciTech Connect

    Shore, V.; Salen, G.; Cheng, F.W.; Forte, T.; Shefer, S.; Tint, G.S.

    1981-11-01

    The plasma lipoprotein profiles and high density lipoproteins (HDL) were characterized in patients with the genetic disease cerebrotendinous xanthomatosis (CTX). The mean HDL-cholesterol concentration in the CTX plasmas was 14.5 +/- 3.2 mg/dl, about one-third the normal value. The low HDL-cholesterol reflects a low concentration and an abnormal lipid composition of the plasma HDL. Relative to normal HDL, the cholesteryl esters are low, free cholesterol and phospholipids essentially normal, and triglycerides increased. The ratio of apoprotein (apo) to total cholesterol in the HDL of CTX was two to three times greater than normal. In the CTX HDL, the ratio of apoAI to apoAII was high, the proportion of apoC low, and a normally minor form of apoAI increased relative to other forms. The HDL in electron micrographs appeared normal morphologically and in particle size. The adnormalities in lipoprotein distribution profiles and composition of the plasma HDL result from metabolic defects that are not understood but may be linked to the genetic defect in bile acid synthesis in CTX. As a consequence, it is probable that the normal functions of the HDL, possibly including modulation of LDL-cholesterol uptake and the removal of excess cholesterol from peripheral tissues, are perturbed significantly in this disease.

  5. High Prevalence of Prothrombotic Abnormalities in Multifocal Osteonecrosis

    PubMed Central

    Peris, Pilar; Reverter, Joan Carles; Espinosa, Gerard; Martinez-Ferrer, Angeles; Monegal, Ana; Monteagudo, Juan; Tàssies, Dolors; Guañabens, Nuria

    2013-01-01

    Abstract Multifocal or multiple osteonecrosis (ON), defined by the involvement of 3 or more anatomic sites, is unusual, being observed in only 3%–10% of patients diagnosed with ON. We report the clinical characteristics of a cohort of 29 patients with multifocal ON from a single center and evaluate the prevalence of associated prothrombotic abnormalities in 26 of these patients. We conducted a retrospective study of all patients diagnosed with multifocal ON evaluated in our institution during the last 20 years. We recorded clinical manifestations and underlying diagnoses. A wide thrombophilic profile was performed, including antithrombin, protein C, protein S, lupus anticoagulant, anticardiolipin antibodies, activated protein C resistance, factor V Leiden, mutation G-20210-A of the prothrombin gene, and factor VIII. Coagulation test results were compared with those in a healthy control group and a group of patients with history of lower-extremity deep venous thrombosis. The mean age of the patients was 49.2 ± 15 years (range, 28–81 yr). The mean number of ON localizations per patient was 5.2 ± 2.3 (range, 3–11). Hips were the most commonly affected joint (82%), followed by knees (58%), shoulders (37%), and ankles (13%). Most patients had an underlying disease process, and 12 of 25 (48%) patients had coagulation test abnormalities. The most common alterations were high factor VIII levels and antiphospholipid antibody (aPL) positivity in 24% and 20% of cases, respectively. These abnormalities were more prevalent in patients with multifocal ON compared with patients in the control groups. Sixty-one percent of patients had a history of corticosteroid treatment. Patients with coagulation abnormalities had a higher number of ON localizations per patient (6.5 ± 2.7 vs. 3.88 ± 0.8; p = 0.002) and a higher prevalence of atypical ON localizations (25% vs. 0%; p = 0.05). In conclusion, in the present cohort of patients with multifocal ON, 48% of the patients had at

  6. A small number of abnormal brain connections predicts adult autism spectrum disorder

    PubMed Central

    Yahata, Noriaki; Morimoto, Jun; Hashimoto, Ryuichiro; Lisi, Giuseppe; Shibata, Kazuhisa; Kawakubo, Yuki; Kuwabara, Hitoshi; Kuroda, Miho; Yamada, Takashi; Megumi, Fukuda; Imamizu, Hiroshi; Náñez Sr, José E.; Takahashi, Hidehiko; Okamoto, Yasumasa; Kasai, Kiyoto; Kato, Nobumasa; Sasaki, Yuka; Watanabe, Takeo; Kawato, Mitsuo

    2016-01-01

    Although autism spectrum disorder (ASD) is a serious lifelong condition, its underlying neural mechanism remains unclear. Recently, neuroimaging-based classifiers for ASD and typically developed (TD) individuals were developed to identify the abnormality of functional connections (FCs). Due to over-fitting and interferential effects of varying measurement conditions and demographic distributions, no classifiers have been strictly validated for independent cohorts. Here we overcome these difficulties by developing a novel machine-learning algorithm that identifies a small number of FCs that separates ASD versus TD. The classifier achieves high accuracy for a Japanese discovery cohort and demonstrates a remarkable degree of generalization for two independent validation cohorts in the USA and Japan. The developed ASD classifier does not distinguish individuals with major depressive disorder and attention-deficit hyperactivity disorder from their controls but moderately distinguishes patients with schizophrenia from their controls. The results leave open the viable possibility of exploring neuroimaging-based dimensions quantifying the multiple-disorder spectrum. PMID:27075704

  7. A small number of abnormal brain connections predicts adult autism spectrum disorder.

    PubMed

    Yahata, Noriaki; Morimoto, Jun; Hashimoto, Ryuichiro; Lisi, Giuseppe; Shibata, Kazuhisa; Kawakubo, Yuki; Kuwabara, Hitoshi; Kuroda, Miho; Yamada, Takashi; Megumi, Fukuda; Imamizu, Hiroshi; Náñez, José E; Takahashi, Hidehiko; Okamoto, Yasumasa; Kasai, Kiyoto; Kato, Nobumasa; Sasaki, Yuka; Watanabe, Takeo; Kawato, Mitsuo

    2016-01-01

    Although autism spectrum disorder (ASD) is a serious lifelong condition, its underlying neural mechanism remains unclear. Recently, neuroimaging-based classifiers for ASD and typically developed (TD) individuals were developed to identify the abnormality of functional connections (FCs). Due to over-fitting and interferential effects of varying measurement conditions and demographic distributions, no classifiers have been strictly validated for independent cohorts. Here we overcome these difficulties by developing a novel machine-learning algorithm that identifies a small number of FCs that separates ASD versus TD. The classifier achieves high accuracy for a Japanese discovery cohort and demonstrates a remarkable degree of generalization for two independent validation cohorts in the USA and Japan. The developed ASD classifier does not distinguish individuals with major depressive disorder and attention-deficit hyperactivity disorder from their controls but moderately distinguishes patients with schizophrenia from their controls. The results leave open the viable possibility of exploring neuroimaging-based dimensions quantifying the multiple-disorder spectrum. PMID:27075704

  8. High Reynolds number research - 1980

    NASA Technical Reports Server (NTRS)

    Mckinney, L. W. (Editor); Baals, D. D. (Editor)

    1981-01-01

    The fundamental aerodynamic questions for which high Reynolds number experimental capability is required were examined. Potential experiments which maximize the research returns from the use of the National Transonic Facility (NTF) were outlined. Calibration plans were reviewed and the following topics were discussed: fluid dynamics; high lit; configuration aerodynamics; aeroelasticity and unsteady aerodynamics; wind tunnel/flight correlation; space vehicles; and theoretical aerodynamics

  9. Abnormal Elastic and Vibrational Behaviors of Magnetite at High Pressures

    NASA Astrophysics Data System (ADS)

    Lin, Jung-Fu; Wu, Junjie; Zhu, Jie; Mao, Zhu; Said, Ayman H.; Leu, Bogdan M.; Cheng, Jinguang; Uwatoko, Yoshiya; Jin, Changqing; Zhou, Jianshi

    2014-09-01

    Magnetite exhibits unique electronic, magnetic, and structural properties in extreme conditions that are of great research interest. Previous studies have suggested a number of transitional models, although the nature of magnetite at high pressure remains elusive. We have studied a highly stoichiometric magnetite using inelastic X-ray scattering, X-ray diffraction and emission, and Raman spectroscopies in diamond anvil cells up to ~20 GPa, while complementary electrical conductivity measurements were conducted in a cubic anvil cell up to 8.5 GPa. We have observed an elastic softening in the diagonal elastic constants (C11 and C44) and a hardening in the off-diagonal constant (C12) at ~8 GPa where significant elastic anisotropies in longitudinal and transverse acoustic waves occur, especially along the [110] direction. An additional vibrational Raman band between the A1g and T2g modes was also detected at the transition pressure. These abnormal elastic and vibrational behaviors of magnetite are attributed to the occurrence of the octahedrally-coordinated Fe2+-Fe3+-Fe2+ ions charge-ordering along the [110] direction in the inverse spinel structure. We propose a new phase diagram of magnetite in which the temperature for the metal-insulator and distorted structural transitions decreases with increasing pressure while the charge-ordering transition occurs at ~8 GPa and room temperature.

  10. Abnormal Elastic and Vibrational Behaviors of Magnetite at High Pressures

    PubMed Central

    Lin, Jung-Fu; Wu, Junjie; Zhu, Jie; Mao, Zhu; Said, Ayman H.; Leu, Bogdan M.; Cheng, Jinguang; Uwatoko, Yoshiya; Jin, Changqing; Zhou, Jianshi

    2014-01-01

    Magnetite exhibits unique electronic, magnetic, and structural properties in extreme conditions that are of great research interest. Previous studies have suggested a number of transitional models, although the nature of magnetite at high pressure remains elusive. We have studied a highly stoichiometric magnetite using inelastic X-ray scattering, X-ray diffraction and emission, and Raman spectroscopies in diamond anvil cells up to ~20 GPa, while complementary electrical conductivity measurements were conducted in a cubic anvil cell up to 8.5 GPa. We have observed an elastic softening in the diagonal elastic constants (C11 and C44) and a hardening in the off-diagonal constant (C12) at ~8 GPa where significant elastic anisotropies in longitudinal and transverse acoustic waves occur, especially along the [110] direction. An additional vibrational Raman band between the A1g and T2g modes was also detected at the transition pressure. These abnormal elastic and vibrational behaviors of magnetite are attributed to the occurrence of the octahedrally-coordinated Fe2+-Fe3+-Fe2+ ions charge-ordering along the [110] direction in the inverse spinel structure. We propose a new phase diagram of magnetite in which the temperature for the metal-insulator and distorted structural transitions decreases with increasing pressure while the charge-ordering transition occurs at ~8 GPa and room temperature. PMID:25186916

  11. Abnormal elastic and vibrational behaviors of magnetite at high pressures.

    PubMed

    Lin, Jung-Fu; Wu, Junjie; Zhu, Jie; Mao, Zhu; Said, Ayman H; Leu, Bogdan M; Cheng, Jinguang; Uwatoko, Yoshiya; Jin, Changqing; Zhou, Jianshi

    2014-01-01

    Magnetite exhibits unique electronic, magnetic, and structural properties in extreme conditions that are of great research interest. Previous studies have suggested a number of transitional models, although the nature of magnetite at high pressure remains elusive. We have studied a highly stoichiometric magnetite using inelastic X-ray scattering, X-ray diffraction and emission, and Raman spectroscopies in diamond anvil cells up to ~20 GPa, while complementary electrical conductivity measurements were conducted in a cubic anvil cell up to 8.5 GPa. We have observed an elastic softening in the diagonal elastic constants (C11 and C44) and a hardening in the off-diagonal constant (C12) at ~8 GPa where significant elastic anisotropies in longitudinal and transverse acoustic waves occur, especially along the [110] direction. An additional vibrational Raman band between the A1g and T2g modes was also detected at the transition pressure. These abnormal elastic and vibrational behaviors of magnetite are attributed to the occurrence of the octahedrally-coordinated Fe(2+)-Fe(3+)-Fe(2+) ions charge-ordering along the [110] direction in the inverse spinel structure. We propose a new phase diagram of magnetite in which the temperature for the metal-insulator and distorted structural transitions decreases with increasing pressure while the charge-ordering transition occurs at ~8 GPa and room temperature. PMID:25186916

  12. Quasiperpendicular High Mach Number Shocks.

    PubMed

    Sulaiman, A H; Masters, A; Dougherty, M K; Burgess, D; Fujimoto, M; Hospodarsky, G B

    2015-09-18

    Shock waves exist throughout the Universe and are fundamental to understanding the nature of collisionless plasmas. Reformation is a process, driven by microphysics, which typically occurs at high Mach number supercritical shocks. While ongoing studies have investigated this process extensively both theoretically and via simulations, their observations remain few and far between. In this Letter we present a study of very high Mach number shocks in a parameter space that has been poorly explored and we identify reformation using in situ magnetic field observations from the Cassini spacecraft at 10 AU. This has given us an insight into quasiperpendicular shocks across 2 orders of magnitude in Alfvén Mach number (M_{A}) which could potentially bridge the gap between modest terrestrial shocks and more exotic astrophysical shocks. For the first time, we show evidence for cyclic reformation controlled by specular ion reflection occurring at the predicted time scale of ~0.3τ_{c}, where τ_{c} is the ion gyroperiod. In addition, we experimentally reveal the relationship between reformation and M_{A} and focus on the magnetic structure of such shocks to further show that for the same M_{A}, a reforming shock exhibits stronger magnetic field amplification than a shock that is not reforming. PMID:26430997

  13. Quasiperpendicular High Mach Number Shocks

    NASA Astrophysics Data System (ADS)

    Sulaiman, A. H.; Masters, A.; Dougherty, M. K.; Burgess, D.; Fujimoto, M.; Hospodarsky, G. B.

    2015-09-01

    Shock waves exist throughout the Universe and are fundamental to understanding the nature of collisionless plasmas. Reformation is a process, driven by microphysics, which typically occurs at high Mach number supercritical shocks. While ongoing studies have investigated this process extensively both theoretically and via simulations, their observations remain few and far between. In this Letter we present a study of very high Mach number shocks in a parameter space that has been poorly explored and we identify reformation using in situ magnetic field observations from the Cassini spacecraft at 10 AU. This has given us an insight into quasiperpendicular shocks across 2 orders of magnitude in Alfvén Mach number (MA ) which could potentially bridge the gap between modest terrestrial shocks and more exotic astrophysical shocks. For the first time, we show evidence for cyclic reformation controlled by specular ion reflection occurring at the predicted time scale of ˜0.3 τc , where τc is the ion gyroperiod. In addition, we experimentally reveal the relationship between reformation and MA and focus on the magnetic structure of such shocks to further show that for the same MA , a reforming shock exhibits stronger magnetic field amplification than a shock that is not reforming.

  14. High incidence of MYC and BCL2 abnormalities in mantle cell lymphoma, although only MYC abnormality predicts poor survival

    PubMed Central

    Li, Chengwen; Zhong, Shizhen; Chen, Weiwei; Li, Zengjun; Xiong, Wenjie; Liu, Wei; Liu, Enbin; Cui, Rui; Ru, Kun; Zhang, Peihong; Xu, Yan; An, Gang; Lv, Rui; Qi, Junyuan; Wang, Jianxiang; Cheng, Tao; Qiu, Lugui

    2015-01-01

    The incidence and prognostic role of MYC and BCL2 rearrangements in mature B-cell lymphomas have been extensively studied, except the infrequent mantle cell lymphoma (MCL). Here, we analyzed the MYC and BCL2 abnormalities and other cytogenetic aberrations by fluorescence in situ hybridization (FISH) in 50 MCL patients with bone marrow involvement. Eighteen patients (36.0%) had MYC gains and/or amplifications, and twelve patients (24.0%) had BCL2 gains and/or amplifications. Among the 18 patients with MYC abnormality, four had simultaneous MYC translocations, but no BCL2 translocation was detected among patients with BCL2 abnormality. Only two patients (4.0%) had both MYC and BCL2 abnormalities. The patients with a MYC abnormality had a significantly higher tumor burden, a higher percentage of medium/high risk MIPI group and genomic instability compared to those without this abnormality. However, no significant difference was observed between patients with or without a BCL2 abnormality in terms of clinical and cytogenetic factors. Patients with a MYC abnormality had poorer progress-free survival (PFS) (9.0 vs. 48.0 months, p = .000) and overall survival (OS) (12.0 vs. 94.5 months, p = .000), but the presence of a BCL2 abnormality did not significantly influence either PFS or OS. In multivariate analysis, the MYC abnormality was the independent adverse factor for both PFS and OS, and intensive chemotherapy did not improve the outcome of these patients. Thus, the presence of a MYC but not BCL2 abnormality predicted the poor survival of MCL patients, and a new treatment strategy should be developed for these patients. PMID:26517511

  15. Somatosensory Profiles but Not Numbers of Somatosensory Abnormalities of Neuropathic Pain Patients Correspond with Neuropathic Pain Grading

    PubMed Central

    Konopka, Karl-Heinz; Harbers, Marten; Houghton, Andrea; Kortekaas, Rudie; van Vliet, Andre; Timmerman, Wia; den Boer, Johan A.; Struys, Michel M. R. F.; van Wijhe, Marten

    2012-01-01

    Due to the lack of a specific diagnostic tool for neuropathic pain, a grading system to categorize pain as ‘definite’, ‘probable’, ‘possible’ and ‘unlikely’ neuropathic was proposed. Somatosensory abnormalities are common in neuropathic pain and it has been suggested that a greater number of abnormalities would be present in patients with ‘probable’ and ‘definite’ grades. To test this hypothesis, we investigated the presence of somatosensory abnormalities by means of Quantitative Sensory Testing (QST) in patients with a clinical diagnosis of neuropathic pain and correlated the number of sensory abnormalities and sensory profiles to the different grades. Of patients who were clinically diagnosed with neuropathic pain, only 60% were graded as ‘definite’ or ‘probable’, while 40% were graded as ‘possible’ or ‘unlikely’ neuropathic pain. Apparently, there is a mismatch between a clinical neuropathic pain diagnosis and neuropathic pain grading. Contrary to the expectation, patients with ‘probable’ and ‘definite’ grades did not have a greater number of abnormalities. Instead, similar numbers of somatosensory abnormalities were identified for each grade. The profiles of sensory signs in ‘definite’ and ‘probable’ neuropathic pain were not significantly different, but different from the ‘unlikely’ grade. This latter difference could be attributed to differences in the prevalence of patients with a mixture of sensory gain and loss and with sensory loss only. The grading system allows a separation of neuropathic and non-neuropathic pain based on profiles but not on the total number of sensory abnormalities. Our findings indicate that patient selection based on grading of neuropathic pain may provide advantages in selecting homogenous groups for clinical research. PMID:22927981

  16. Erythrocyte echinocytosis in liver disease. Role of abnormal plasma high density lipoproteins.

    PubMed Central

    Owen, J S; Brown, D J; Harry, D S; McIntyre, N; Beaven, G H; Isenberg, H; Gratzer, W B

    1985-01-01

    Echinocytes were frequently found in patients with liver disease when their blood was examined in wet films, but rarely detected in dried, stained smears. When normal erythrocytes (discocytes) were incubated with physiologic concentrations of the abnormal high density lipoproteins (HDL) from some jaundiced patients, echinocytosis developed within seconds. Other plasma fractions were not echinocytogenic. There was a close correlation between the number of echinocytes found in vivo and the ability of the corresponding HDL to induce discocyte-echinocyte transformation. On incubation with normal HDL, echinocytes generated in vitro rapidly reverted to a normal shape, and echinocytes from patients showed a similar trend. Echinocytosis occurred without change in membrane cholesterol content, as did its reversal, and was not caused by membrane uptake of lysolecithin or bile acids. Abnormal, echinocytogenic HDL showed saturable binding to approximately 5,000 sites per normal erythrocyte with an association constant of 10(8) M-1. Nonechinocytogenic patient HDL and normal HDL showed only nonsaturable binding. Several minor components of electrophoretically separated erythrocyte membrane proteins bound the abnormal HDL; pretreatment of the cells with trypsin or pronase reduced or eliminated binding. Echinocytosis by abnormal HDL required receptor occupancy, rather than transfer of constituents to or from the membrane, because cells reversibly prefixed in the discoid shape by wheat germ agglutinin, and then exposed to abnormal HDL, did not become echinocytes when the HDL and lectin were successively removed. Binding did not cause dephosphorylation of spectrin. We conclude that the echinocytes of liver disease are generated from discocytes by abnormal HDL, and we infer that the shape change is mediated by cell-surface receptors for abnormal HDL molecules. Images PMID:4077979

  17. Copy number variants and rasopathies: germline KRAS duplication in a patient with syndrome including pigmentation abnormalities.

    PubMed

    Gilbert-Dussardier, Brigitte; Briand-Suleau, Audrey; Laurendeau, Ingrid; Bilan, Frédéric; Cavé, Hélène; Verloes, Alain; Vidaud, Michel; Vidaud, Dominique; Pasmant, Eric

    2016-01-01

    RAS/MAPK pathway germline mutations were described in Rasopathies, a class of rare genetic syndromes combining facial abnormalities, heart defects, short stature, skin and genital abnormalities, and mental retardation. The majority of the mutations identified in the Rasopathies are point mutations which increase RAS/MAPK pathway signaling. Duplications encompassing RAS/MAPK pathway genes (PTPN11, RAF1, MEK2, or SHOC2) were more rarely described. Here we report, a syndromic familial case of a 12p duplication encompassing the dosage sensitive gene KRAS, whose phenotype overlapped with rasopathies. The patient was referred because of a history of mild learning disabilities, small size, facial dysmorphy, and pigmentation abnormalities (café-au-lait and achromic spots, and axillar lentigines). This phenotype was reminiscent of rasopathies. No mutation was identified in the most common genes associated with Noonan, cardio-facio-cutaneous, Legius, and Costello syndromes, as well as neurofibromatosis type 1. The patient constitutional DNA exhibited a ~10.5 Mb duplication at 12p, including the KRAS gene. The index case's mother carried the same chromosome abnormality and also showed development delay with short stature, and numerous café-au-lait spots. Duplication of the KRAS gene may participate in the propositus phenotype, in particular of the specific pigmentation abnormalities. Array-CGH or some other assessment of gene/exon CNVs of RAS/MAPK pathway genes should be considered in the evaluation of individuals with rasopathies. PMID:27450488

  18. Relationship between paravascular abnormalities and foveoschisis in highly myopic patients

    PubMed Central

    Kamal-Salah, R; Morillo-Sanchez, M J; Rius-Diaz, F; Garcia-Campos, J M

    2015-01-01

    Purpose To describe the prevalence of paravascular abnormalities in highly myopic patients and its relationship with myopic foveoschisis (MF). Methods Cross-sectional study of 250 highly myopic eyes. All of the patients underwent a complete ophthalmologic examination that included optical coherence tomography . Results Optical coherence tomography images showed 170 eyes (68%) with paravascular microfolds (PM), 121 eyes (48.4%) presented paravascular retinal cysts (PC), and 35 eyes (14%) with paravascular lamellar holes . All the eyes with PCs had PMs. Out of the 250 eyes, 48 (19.2%) had paravascular retinoschisis (PR). All the eyes (100%) with PR had paravascular cysts and PMs. Sixteen eyes (6.4%) had foveoschis. The spherical equivalent (P<0.00), PR (P=0.01), and the presence of tractional structures (P<0.00) were associated with increased risk for foveoschsis in the multivariate study. Conclusions PMs were the lesions most often observed in the paravascular area in highly myopic eyes. MF would be a result of the action of different forces (intra- and extra-ocular forces), specially tractional structures, on precursor lesions (paravascular cyst and paravascular restinoschisis). Further studies are needed to confirm these results. PMID:25359287

  19. Number Theory in the High School Classroom.

    ERIC Educational Resources Information Center

    Dence, Thomas

    1999-01-01

    Demonstrates some of the usefulness of number theory to students on the high school setting in four areas: Fibonacci numbers, Diophantine equations, continued fractions, and algorithms for computing pi. (ASK)

  20. Abnormally high expression of proteasomes in human leukemic cells.

    PubMed Central

    Kumatori, A; Tanaka, K; Inamura, N; Sone, S; Ogura, T; Matsumoto, T; Tachikawa, T; Shin, S; Ichihara, A

    1990-01-01

    Proteasomes are eukaryotic ring-shaped or cylindrical particles with multicatalytic protease activities. To clarify the involvement of proteasomes in tumorigenesis of human blood cells, we compared their expression in human hematopoietic malignant tumor cells with that in normal peripheral blood mononuclear cells. Immunohistochemical staining showed considerably increased concentrations of proteasomes in leukemic cells from the bone marrow of patients with various types of leukemia and the predominant localization of these proteasomes in the nuclei. Moreover, enzyme immunoassay and Northern blot analysis indicated that the concentrations of proteasomes and their mRNA levels were consistently much higher in a variety of malignant human hematopoietic cell lines than in resting peripheral lymphocytes and monocytes from healthy adults. Proteasome expression was also greatly increased in normal blood mononuclear cells during blastogenic transformation induced by phytohemagglutinin; their expression increased in parallel with induction of DNA synthesis and returned to the basal level with progress of the cell cycle. Thus, abnormally high expression of proteasomes may play an important role in transformation and proliferation of blood cells and in specific functions of hematopoietic tumor cells. Images PMID:2205851

  1. High prevalence of thyroid ultrasonographic abnormalities in primary aldosteronism.

    PubMed

    Armanini, Decio; Nacamulli, Davide; Scaroni, Carla; Lumachi, Franco; Selice, Riccardo; Fiore, Cristina; Favia, Gennaro; Mantero, Franco

    2003-11-01

    The study was performed to evaluate the prevalence of thyroid abnormalities detected by ultrasonography and, in particular, of multinodular nontoxic goiter in primary aldosteronism. We analyzed 80 consecutive of patients with primary hyperaldosteronism (40 with unilateral adenoma and 40 with idiopathic hyperaldosteronism) and 80 normotensive healthy controls, comparable for age, sex, iodine intake, and geographical area. Blood pressure, thyroid palpation, thyroid function, and ultrasonography were evaluated. The prevalence of ultrasonographic thyroid abnormalities was 60% in primary aldosteronism and 27% in controls (p < 0.0001). There was a statistically significant difference in prevalence of these abnormalities in unilateral adenoma and idiopathic hyperaldosteronism with respect to controls (p < 0.05 and p < 0.0001, respectively). The prevalence of multinodular nontoxic goiter in idiopathic hyperaldosteronism was higher than in controls (p < 0.001) and, in particular, in female patients. From these data it seems to be worth considering the existence of primary hyperaldosteronism in patients with multinodular goiter and hypertension. PMID:14665720

  2. Report to Congress on abnormal occurrences: April--June 1995. Volume 18, Number 2

    SciTech Connect

    1995-10-01

    Section 208 of the Energy Reorganization Act of 1974 identifies an abnormal occurrence (AO) as an unscheduled incident or event that the Nuclear Regulatory Commission determines to be significant from the standpoint of public health or safety and requires a quarterly report of such occurrences to be made to Congress. This report provides a description of those incidents and events that have been determined to be AOs during the period of April 1 through June 30, 1995. This report addresses five AOs at NRC-licensed facilities. One involved a reactor coolant system blowdown at a pressurized water reactor (PWR) nuclear power plant, one involved a previously unidentified path for the potential release of radioactivity at a PWR nuclear power plant, two involved medical brachytherapy misadministrations, and one involved a medical therapeutic radiopharmaceutical misadministration. Four AOs submitted by the Agreement States are included. One involved a medical teletherapy misadministration, two involved medical brachytherapy misadministrations, and one involved the overexposure of personnel at a medical center. The report also contains an update of one AO previously reported by an NRC licensee, and two AOs previously reported by the Agreement States. No ``Other Events of Interest`` items are being reported.

  3. Rare DNA copy number variants in cardiovascular malformations with extracardiac abnormalities

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Clinically significant cardiovascular malformations (CVMs) occur in 5-8 per 1000 live births. Recurrent copy number variations (CNVs) are among the known causes of syndromic CVMs, accounting for an important fraction of cases. We hypothesized that many additional rare CNVs also cause CVMs and can be...

  4. 14 CFR 91.144 - Temporary restriction on flight operations during abnormally high barometric pressure conditions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... during abnormally high barometric pressure conditions. 91.144 Section 91.144 Aeronautics and Space... flight operations during abnormally high barometric pressure conditions. (a) Special flight restrictions. When any information indicates that barometric pressure on the route of flight currently exceeds...

  5. 14 CFR 91.144 - Temporary restriction on flight operations during abnormally high barometric pressure conditions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... during abnormally high barometric pressure conditions. 91.144 Section 91.144 Aeronautics and Space... flight operations during abnormally high barometric pressure conditions. (a) Special flight restrictions. When any information indicates that barometric pressure on the route of flight currently exceeds...

  6. 14 CFR 91.144 - Temporary restriction on flight operations during abnormally high barometric pressure conditions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... during abnormally high barometric pressure conditions. 91.144 Section 91.144 Aeronautics and Space... flight operations during abnormally high barometric pressure conditions. (a) Special flight restrictions. When any information indicates that barometric pressure on the route of flight currently exceeds...

  7. 14 CFR 91.144 - Temporary restriction on flight operations during abnormally high barometric pressure conditions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... during abnormally high barometric pressure conditions. 91.144 Section 91.144 Aeronautics and Space... flight operations during abnormally high barometric pressure conditions. (a) Special flight restrictions. When any information indicates that barometric pressure on the route of flight currently exceeds...

  8. 14 CFR 91.144 - Temporary restriction on flight operations during abnormally high barometric pressure conditions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... during abnormally high barometric pressure conditions. 91.144 Section 91.144 Aeronautics and Space... flight operations during abnormally high barometric pressure conditions. (a) Special flight restrictions. When any information indicates that barometric pressure on the route of flight currently exceeds...

  9. Abnormalities of follicular helper T-cell number and function in Wiskott-Aldrich syndrome.

    PubMed

    Zhang, Xuan; Dai, Rongxin; Li, Wenyan; Zhao, Hongyi; Zhang, Yongjie; Zhou, Lina; Du, Hongqiang; Luo, Guangjin; Wu, Junfeng; Niu, Linlin; An, Yunfei; Zhang, Zhiyong; Ding, Yuan; Song, Wenxia; Liu, Chaohong; Zhao, Xiaodong

    2016-06-23

    Wiskott-Aldrich syndrome protein (WASp) is a hematopoietic-specific regulator of actin nucleation. Wiskott-Aldrich syndrome (WAS) patients show immunodeficiencies, most of which have been attributed to defective T-cell functions. T follicular helper (Tfh) cells are the major CD4(+) T-cell subset with specialized B-cell helper capabilities. Aberrant Tfh cells activities are involved in immunopathologies such as autoimmunity, immunodeficiencies, and lymphomas. We found that in WAS patients, the number of circulating Tfh cells was significantly reduced due to reduced proliferation and increased apoptosis, and Tfh cells were Th2 and Th17 polarized. The expression of inducible costimulator (ICOS) in circulating Tfh cells was higher in WAS patients than in controls. BCL6 expression was decreased in total CD4(+) T and Tfh cells of WAS patients. Mirroring the results in patients, the frequency of Tfh cells in WAS knockout (KO) mice was decreased, as was the frequency of BCL6(+) Tfh cells, but the frequency of ICOS(+) Tfh cells was increased. Using WAS chimera mice, we found that the number of ICOS(+) Tfh cells was decreased in WAS chimera mice, indicating that the increase in ICOS(+) Tfh cells in WAS KO mice was cell extrinsic. The data from in vivo CD4(+) naive T-cell adoptive transfer mice as well as in vitro coculture of naive B and Tfh cells showed that the defective function of WASp-deficient Tfh cells was T-cell intrinsic. Consistent findings in both WAS patients and WAS KO mice suggested an essential role for WASp in the development and memory response of Tfh cells and that WASp deficiency causes a deficient differentiation defect in Tfh cells by downregulating the transcription level of BCL6. PMID:27170596

  10. Abnormalities of follicular helper T-cell number and function in Wiskott-Aldrich syndrome

    PubMed Central

    Zhang, Xuan; Dai, Rongxin; Li, Wenyan; Zhao, Hongyi; Zhang, Yongjie; Zhou, Lina; Du, Hongqiang; Luo, Guangjin; Wu, Junfeng; Niu, Linlin; An, Yunfei; Zhang, Zhiyong; Ding, Yuan; Song, Wenxia; Liu, Chaohong

    2016-01-01

    Wiskott-Aldrich syndrome protein (WASp) is a hematopoietic-specific regulator of actin nucleation. Wiskott-Aldrich syndrome (WAS) patients show immunodeficiencies, most of which have been attributed to defective T-cell functions. T follicular helper (Tfh) cells are the major CD4+ T-cell subset with specialized B-cell helper capabilities. Aberrant Tfh cells activities are involved in immunopathologies such as autoimmunity, immunodeficiencies, and lymphomas. We found that in WAS patients, the number of circulating Tfh cells was significantly reduced due to reduced proliferation and increased apoptosis, and Tfh cells were Th2 and Th17 polarized. The expression of inducible costimulator (ICOS) in circulating Tfh cells was higher in WAS patients than in controls. BCL6 expression was decreased in total CD4+ T and Tfh cells of WAS patients. Mirroring the results in patients, the frequency of Tfh cells in WAS knockout (KO) mice was decreased, as was the frequency of BCL6+ Tfh cells, but the frequency of ICOS+ Tfh cells was increased. Using WAS chimera mice, we found that the number of ICOS+ Tfh cells was decreased in WAS chimera mice, indicating that the increase in ICOS+ Tfh cells in WAS KO mice was cell extrinsic. The data from in vivo CD4+ naive T-cell adoptive transfer mice as well as in vitro coculture of naive B and Tfh cells showed that the defective function of WASp-deficient Tfh cells was T-cell intrinsic. Consistent findings in both WAS patients and WAS KO mice suggested an essential role for WASp in the development and memory response of Tfh cells and that WASp deficiency causes a deficient differentiation defect in Tfh cells by downregulating the transcription level of BCL6. PMID:27170596

  11. Rare DNA copy number variants in cardiovascular malformations with extracardiac abnormalities

    PubMed Central

    Lalani, Seema R; Shaw, Chad; Wang, Xueqing; Patel, Ankita; Patterson, Lance W; Kolodziejska, Katarzyna; Szafranski, Przemyslaw; Ou, Zhishuo; Tian, Qi; Kang, Sung-Hae L; Jinnah, Amina; Ali, Sophia; Malik, Aamir; Hixson, Patricia; Potocki, Lorraine; Lupski, James R; Stankiewicz, Pawel; Bacino, Carlos A; Dawson, Brian; Beaudet, Arthur L; Boricha, Fatima M; Whittaker, Runako; Li, Chumei; Ware, Stephanie M; Cheung, Sau Wai; Penny, Daniel J; Jefferies, John Lynn; Belmont, John W

    2013-01-01

    Clinically significant cardiovascular malformations (CVMs) occur in 5–8 per 1000 live births. Recurrent copy number variations (CNVs) are among the known causes of syndromic CVMs, accounting for an important fraction of cases. We hypothesized that many additional rare CNVs also cause CVMs and can be detected in patients with CVMs plus extracardiac anomalies (ECAs). Through a genome-wide survey of 203 subjects with CVMs and ECAs, we identified 55 CNVs >50 kb in length that were not present in children without known cardiovascular defects (n=872). Sixteen unique CNVs overlapping these variants were found in an independent CVM plus ECA cohort (n=511), which were not observed in 2011 controls. The study identified 12/16 (75%) novel loci including non-recurrent de novo 16q24.3 loss (4/714) and de novo 2q31.3q32.1 loss encompassing PPP1R1C and PDE1A (2/714). The study also narrowed critical intervals in three well-recognized genomic disorders of CVM, such as the cat-eye syndrome region on 22q11.1, 8p23.1 loss encompassing GATA4 and SOX7 and 17p13.3-p13.2 loss. An analysis of protein-interaction databases shows that the rare inherited and de novo CNVs detected in the combined cohort are enriched for genes encoding proteins that are direct or indirect partners of proteins known to be required for normal cardiac development. Our findings implicate rare variants such as 16q24.3 loss and 2q31.3-q32.1 loss, and delineate regions within previously reported structural variants known to cause CVMs. PMID:22929023

  12. Decay of turbulence at high reynolds numbers.

    PubMed

    Sinhuber, Michael; Bodenschatz, Eberhard; Bewley, Gregory P

    2015-01-23

    Turbulent motions in a fluid decay at a certain rate once stirring has stopped. The role of the most basic parameter in fluid mechanics, the Reynolds number, in setting the decay rate is not generally known. This Letter concerns the high-Reynolds-number limit of the process. In a classical grid-turbulence wind-tunnel experiment that both reaches higher Reynolds numbers than ever before and covers a wide range of them (10^{4}number independent, which contradicts some models and supports others. PMID:25659002

  13. Chaotic behaviour of high Mach number flows

    NASA Technical Reports Server (NTRS)

    Varvoglis, H.; Ghosh, S.

    1985-01-01

    The stability of the super-Alfvenic flow of a two-fluid plasma model with respect to the Mach number and the angle between the flow direction and the magnetic field is investigated. It is found that, in general, a large scale chaotic region develops around the initial equilibrium of the laminar flow when the Mach number exceeds a certain threshold value. After reaching a maximum the size of this region begins shrinking and goes to zero as the Mach number tends to infinity. As a result high Mach number flows in time independent astrophysical plasmas may lead to the formation of 'quasi-shocks' in the presence of little or no dissipation.

  14. Decay of Turbulence at High Reynolds Numbers

    NASA Astrophysics Data System (ADS)

    Sinhuber, Michael; Bodenschatz, Eberhard; Bewley, Gregory P.

    2015-01-01

    Turbulent motions in a fluid decay at a certain rate once stirring has stopped. The role of the most basic parameter in fluid mechanics, the Reynolds number, in setting the decay rate is not generally known. This Letter concerns the high-Reynolds-number limit of the process. In a classical grid-turbulence wind-tunnel experiment that both reaches higher Reynolds numbers than ever before and covers a wide range of them (1 04number independent, which contradicts some models and supports others.

  15. High Reynolds Number Thermal Stability Experiments

    NASA Technical Reports Server (NTRS)

    Emens, Jessica M.; Brown, Sarah P.; Frederick Robert A., Jr.; Wood, A. John

    2004-01-01

    This work represents preliminary thermal stability results for liquid hydrocarbon fuels. High Reynolds Number Thermal Stability experiments with Jet A and RP-1 resulted in a quantitative measurement of the thermal stability. Each fuel flowed through a heated capillary tube that held the outlet temperature at 290 C. An optical pyrometer measured the surface temperature of the tube at 12 locations as a function of time. The High Reynolds Number Thermal Stability number was then determined using standards published by the American Society for Testing and Materials. The results for Jet A showed lower thermal stability than similar tests conducted at another facility. The RP-1 results are the first reported using this technique. Because the temperature rise on the capillary tube during testing for the RP-1 fuels was not significant, a new standard for the testing conditions should be developed for these types of fuels.

  16. Measurements in a High Reynolds Number Wake

    NASA Astrophysics Data System (ADS)

    Hultmark, Marcus; Jimenez, Juan; Bailey, Sean; Smits, Alexander

    2008-11-01

    Experiments were conducted in the Princeton/ONR HRTF windtunnel with highly pressurized air. The wake of a DARPA SUBOFF submarine model was measured over a large range of Reynolds numbers at 5 different downstream locations. The model is an axisymmetric body without appendages (fins) supported by a streamlined support, mimicking a semi-infinite sail. For all Reynolds numbers studied, the mean velocity distribution becomes self-similar between 3 and 6 diameters, D, downstream for the side where the support is not located. In contrast, self-similarity in the Reynolds stresses is not reached at the furthest downstream location (x/D=15). The spectra reveal two peaks in the near-wake. The lower wavenumber peak corresponds to a Strouhal number based on diameter and freestream velocity of about 0.22, suggesting that it is associated with an azimuthal or helical shedding mode in the wake. This mode is evident at all Reynolds numbers, at all cross-stream positions, indicating that it is unlikely to be due to the interference of the support wake with the model wake. The mode is seen only for x/D<15, suggesting that it plays a partial role in the approach to self-similarity of the turbulent stresses.

  17. Quark number fluctuations at high temperatures

    SciTech Connect

    Petreczky, P.; Hegde, P.; Velytsky, A.

    2009-11-01

    We calculate the second, fourth and sixth order quark number fluctuations in the deconfined phase of 2+1 flavor QCD using lattices with temporal extent N{sub t} = 4,6,8 and 12. We consider light, strange and charm quarks. We use p4 action for valence quarks and gauge configurations generated with p4 action with physical value of the strange quark mass and light quark mass m{sub q} = 0.1 m{sub s} generated by the RBC-Bielefeld collaboration. We observe that for all quark masses the quark number fluctuations rapidly get close to the corresponding ideal gas limits. We compare our results to predictions of a quasi-particle model and resummed high temperature perturbative calculations. We also investigate correlations among different flavor channels.

  18. Turbulent convection at high Rayleigh numbers

    NASA Astrophysics Data System (ADS)

    Ahlers, Guenter

    2015-11-01

    Russ Donnelly had a vision of building a ten-meter tall Rayleigh-Bénard convection cell for use at helium temperatures at one of the high-energy physics facilities with very large helium liquefaction capacity. It would have reached Rayleigh numbers in the 1020 range and had the promise of yielding detailed information about the so-called ultimate state of turbulent convection which is highly relevant to many geophysical and astrophysical problems as well as to oceanography and climate physics. Although this was not to happen for reasons beyond his control, a laboratory-sized precursor of this venture yielded data for Ra up to 1017. The results were interpreted to yield no definitive indication of a transition to the ultimate state. This talk will review some of these data and compare them with more recent measurements using SF6 at ambient temperatures and high pressure. This comparison suggests that the Donnelly group actually entered a transition range to the ultimate state near Ra1* ~= 6 ×1012 , but re-entered the classical state at larger Ra because with increasing Ra the Prandtl number (which affects Ra1*) also increased in those experiments. In view of the above, one can estimate that, for the same parameter values, the originally envisioned ten-meter cell could have yielded a range of a couple of decades of Ra in the ultimate state. Supported by NSF Grant DMR11-58514.

  19. Congenital Abnormalities

    MedlinePlus

    ... serious health problems (e.g. Down syndrome ). Single-Gene Abnormalities Sometimes the chromosomes are normal in number, ... blood flow to the fetus impair fetal growth. Alcohol consumption and certain drugs during pregnancy significantly increase ...

  20. Preston Probe Calibrations at High Reynolds Number

    NASA Technical Reports Server (NTRS)

    Smits, Alexander J.

    1998-01-01

    The overall goal of the research effort is to study the performance of two Preston probes designed by NASA Langley Research Center across an unprecedented range of Reynolds number (based on friction velocity and probe diameter), and perform an accurate calibration over the same Reynolds number range. Using the Superpipe facility in Princeton, two rounds of experiments were performed. In each round of experiments for each Reynolds number, the pressure gradient, static pressure from the Preston probes and the total pressure from the Preston probes were measured. In the first round, 3 Preston probes having outer diameters of 0.058 inches, 0.083 inches and 0.203 inches were tested over a large range of pipe Reynolds numbers. Two data reduction methods were employed: first, the static pressure measured on the Preston probe was used to calculate P (modified Preston probe configuration), and secondly, the static pressure measured at the reference pressure tap was used to calculate P (un-modified Preston probe configuration). For both methods, the static pressure was adjusted to correspond with the static pressure at the Preston probe tip using the pressure gradient. The measurements for Preston probes with diameters of 0.058 inches, and 0.083 inches respectively were performed in the test pipe before it was polished a second time. Therefore, the measurements at high pipe Reynolds numbers may have been affected by roughness. In the second round of experiments the 0.058 inches and 0.083 inches diameter, un-modified probes were tested after the pipe was polished and prepared to ensure that the surface was smooth. The average velocity was estimated by assuming that the connection between the centerline velocity and the average velocity was known, and by using a Pitot tube to measure the centerline velocity. A preliminary error estimate suggests that it is possible to introduce a 1% to 2% error in estimating the average velocity using this approach. The evidence on the errors

  1. Binary droplet collision at high Weber number

    NASA Astrophysics Data System (ADS)

    Pan, Kuo-Long; Chou, Ping-Chung; Tseng, Yu-Jen

    2009-09-01

    By using the techniques developed for generating high-speed droplets, we have systematically investigated binary droplet collision when the Weber number (We) was increased from the range usually tested in previous studies on the order of 10 to a much larger value of about 5100 for water (a droplet at 23 m/s with a diameter of 0.7 mm). Various liquids were also used to explore the effects of viscosity and surface tension. Specifically, beyond the well-known regimes at moderate We’s, which exhibited coalescence, separation, and separation followed by satellite droplets, we found different behaviors showing a fingering lamella, separation after fingering, breakup of outer fingers, and prompt splattering into multiple secondary droplets as We was increased. The critical Weber numbers that mark the boundaries between these impact regimes are identified. The specific impact behaviors, such as fingering and prompt splattering or splashing, share essential similarity with those also observed in droplet-surface impacts, whereas substantial variations in the transition boundaries may result from the disparity of the boundary conditions at impacts. To compare the outcomes of both types of collisions, a simple model based on energy conservation was carried out to predict the maximum diameter of an expanding liquid disk for a binary droplet collision. The results oppose the dominance of viscous drag, as proposed by previous studies, as the main deceleration force to effect a Rayleigh-Taylor instability and ensuing periphery fingers, which may further lead to the formations of satellite droplets.

  2. Method of curved surface abnormal holes vision measurement based on high precision turntable

    NASA Astrophysics Data System (ADS)

    Lyu, Laipeng; Bi, Chao; Fang, Jianguo; Zhu, Yong; Wang, Liping

    2015-10-01

    For solving the difficult problem that there is no effective way to measure abnormal holes located at blade erection loop of aero-engine case, an image measurement system based on high precision air-bearing turntable is established in this paper. The issue that monocular vision can't measure curved surface has overcome by using high precision turntable to make sure high positioning accuracy of the surface abnormal holes and high-resolution microscope lens which is used to image local tiny features. Besides, an algorithm of determining the boundary points of a trailing edge on the contour of abnormal hole is proposed to achieve a rapid fitting and accuracy. After experiments and analysis, results show that the system can be used to measure local tiny features on curved surfaces validly and efficiently.

  3. High speed optical quantum random number generation.

    PubMed

    Fürst, Martin; Weier, Henning; Nauerth, Sebastian; Marangon, Davide G; Kurtsiefer, Christian; Weinfurter, Harald

    2010-06-01

    We present a fully integrated, ready-for-use quantum random number generator (QRNG) whose stochastic model is based on the randomness of detecting single photons in attenuated light. We show that often annoying deadtime effects associated with photomultiplier tubes (PMT) can be utilized to avoid postprocessing for bias or correlations. The random numbers directly delivered to a PC, generated at a rate of up to 50 Mbit/s, clearly pass all tests relevant for (physical) random number generators. PMID:20588431

  4. Time Orientation in the Positive and Negative Free Phantasies of Mildly Abnormal Versus Normal High School Males

    ERIC Educational Resources Information Center

    Rychlak, Joseph F.

    1973-01-01

    This study contrasts a group of mildly'' abnormal high school males with matched normals in a two-session free phantasy procedure. Mildly abnormal boys phantasized more negative contents than normal boys. Normal boys projected more positive phantasies into the future than mildly abnormal boys. A logical learning theory'' embracing the…

  5. An Algorithm for the Segmentation of Highly Abnormal Hearts Using a Generic Statistical Shape Model.

    PubMed

    Alba, Xenia; Pereanez, Marco; Hoogendoorn, Corne; Swift, Andrew J; Wild, Jim M; Frangi, Alejandro F; Lekadir, Karim

    2016-03-01

    Statistical shape models (SSMs) have been widely employed in cardiac image segmentation. However, in conditions that induce severe shape abnormality and remodeling, such as in the case of pulmonary hypertension (PH) or hypertrophic cardiomyopathy (HCM), a single SSM is rarely capable of capturing the anatomical variability in the extremes of the distribution. This work presents a new algorithm for the segmentation of severely abnormal hearts. The algorithm is highly flexible, as it does not require a priori knowledge of the involved pathology or any specific parameter tuning to be applied to the cardiac image under analysis. The fundamental idea is to approximate the gross effect of the abnormality with a virtual remodeling transformation between the patient-specific geometry and the average shape of the reference model (e.g., average normal morphology). To define this mapping, a set of landmark points are automatically identified during boundary point search, by estimating the reliability of the candidate points. With the obtained transformation, the feature points extracted from the patient image volume are then projected onto the space of the reference SSM, where the model is used to effectively constrain and guide the segmentation process. The extracted shape in the reference space is finally propagated back to the original image of the abnormal heart to obtain the final segmentation. Detailed validation with patients diagnosed with PH and HCM shows the robustness and flexibility of the technique for the segmentation of highly abnormal hearts of different pathologies. PMID:26552082

  6. High Goblet Cell Count Is Inversely Associated with Ploidy Abnormalities and Risk of Adenocarcinoma in Barrett’s Esophagus

    PubMed Central

    Sanchez, Carissa A.; Liu, Karen; Fong, Pui Yee; Li, Xiaohong; Cowan, David S.; Rabinovitch, Peter S.; Reid, Brian J.; Blount, Patricia L.

    2015-01-01

    Purpose Goblet cells may represent a potentially successful adaptive response to acid and bile by producing a thick mucous barrier that protects against cancer development in Barrett's esophagus (BE). The aim of this study was to determine the relationship between goblet cells (GC) and risk of progression to adenocarcinoma, and DNA content flow cytometric abnormalities, in BE patients. Experimental Design Baseline mucosal biopsies (N=2988) from 213 patients, 32 of whom developed cancer during the follow up period, enrolled in a prospective dynamic cohort of BE patients were scored in a blinded fashion, for the total number (#) of GC, mean # of GC/crypt (GC density), # of crypts with ≥ 1 GC, and the proportion of crypts with ≥1 GC, in both dysplastic and non-dysplastic epithelium separately. The relationship between these four GC parameters and DNA content flow cytometric abnormalities and adenocarcinoma outcome was compared, after adjustment for age, gender, and BE segment length. Results High GC parameters were inversely associated with DNA content flow cytometric abnormalities, such as aneuploidy, ploidy >2.7N, and an elevated 4N fraction > 6%, and with risk of adenocarcinoma. However, a Kaplan-Meier analysis showed that the total # of GC and the total # crypts with ≥1 GC were the only significant GC parameters (p<0.001 and 0.003, respectively). Conclusions The results of this study show, for the first time, an inverse relationship between high GC counts and flow cytometric abnormalities and risk of adenocarcinoma in BE. Further studies are needed to determine if GC depleted foci within esophageal columnar mucosa are more prone to neoplastic progression or whether loss of GC occurs secondary to underlying genetic abnormalities. PMID:26230607

  7. Abnormal Pap Smear and Diagnosis of High-Grade Vaginal Intraepithelial Neoplasia: A Retrospective Cohort Study.

    PubMed

    Sopracordevole, Francesco; Mancioli, Francesca; Clemente, Nicolò; De Piero, Giovanni; Buttignol, Monica; Giorda, Giorgio; Ciavattini, Andrea

    2015-10-01

    The aim of this study was to analyze the correlation between the first diagnosis of high-grade Vaginal Intraepithelial Neoplasia (HG-VaIN: VaIN 2-VaIN 3) and the cytological abnormalities on the referral pap smear.All the women with histological diagnosis of HG-VaIN consecutively referred to the Gynecological Oncology Unit of the Aviano National Cancer Institute (Aviano, Italy) from January 1991 to April 2014 and with a pap smear performed in the 3 months before the diagnosis were considered, and an observational cohort study was performed.A total of 87 women with diagnosis of HG-VaIN were identified. Major cytological abnormalities (HSIL and ASC-H) on the referral pap smear were significantly more frequent than lesser abnormalities (ASC-US and LSIL) in postmenopausal women (64.9% vs 36.7%, P = 0.02) and in women with a previous diagnosis of HPV-related cervical preinvasive or invasive lesions (70.5% vs 39.5%, P = 0.01). Diagnosis of VaIN 3 was preceded by major cytological abnormalities in most of the cases (72.7% vs 27.3%, P < 0.001).The diagnosis of HG-VaIN can be preceded by different abnormalities on referral pap smear. Major abnormalities are usually reported in postmenopausal women and in women with previous cervical HPV-related disease. However, ASC-US or LSIL do not exclude HG-VaIN, especially VaIN2. An accurate examination of the whole vaginal walls (or vaginal vault) must be performed in all the women who underwent colposcopy for an abnormal pap smear, and a biopsy of all suspicious areas is mandatory. PMID:26496321

  8. Cytogenetic abnormalities and genomic copy number variations in EPO (7q22) and SEC-61(7p11) genes in primary myelodysplastic syndromes.

    PubMed

    Mohanty, Purvi; Korgaonkar, Seema; Shanmukhaiah, Chandrakala; Ghosh, Kanjaksha; Vundinti, Babu Rao

    2016-07-01

    Myelodysplastic syndromes (MDSs) are heterogeneous clonal haematopoeitic stem cell disorders characterized by ineffective haematopoeisis, cytopenias and risk of progression to AML. We studied 150 MDS patients for cytogenetic aberrations and 60 patients with normal karyotype and 40 patients harboring cytogenetic abnormalities for copy number variations (CNVs). Cytogenetic abnormalities were detected in 46% of patients with a majority of patients harboring abnormalities of chromosome 7 and del (20q) at frequencies of 16% and 12% respectively. We explored the potential of quantitative multiplex PCR assay of short fluorescent fragments (QMPSF) to identify CNVs and correlated the findings with cytogenetic data and disease prognosis. CNVs (n=31) were detected in 28.3% of karyotypically normal and 23% patients with abnormal karyotype. Genetic losses or deletions (n=26) were more frequent than duplications (n=5). EPO (7q22) and SEC-61(7p11) emerged as new candidate genes susceptible to genetic losses with 57.7% deletions identified in regions on chromosome 7. The CNVs correlated with International Prognostic Scoring System (IPSS) intermediate disease risk group. Our integrative cytogenetic and copy number variation study suggests that abnormalities of chromosome 7 are predominant in Indian population and that they may play a secondary role in disease progression and should be evaluated further for asserting their clinical significance and influence on disease prognosis. PMID:27282568

  9. Abnormal Heart Rate Turbulence Predicts Cardiac Mortality in Low, Intermediate and High Risk Older Adults

    PubMed Central

    Stein, Phyllis K.; Barzilay, Joshua I.

    2011-01-01

    Introduction We examined whether heart rate turbulence (HRT) adds to traditional risk factors for cardiac mortality in older adults at low, intermediate and high risk. Methods and Results N=1298, age ≥65 years, with 24-hour Holter recordings were studied. HRT, which quantifies heart rate response to ventricular premature contractions, was categorized as: both turbulence onset (TO) and turbulence slope (TS) normal; TO abnormal; TS abnormal; or both abnormal. Independent risks for cardiac mortality associated with HRT or, for comparison, elevated C-reactive protein (CRP) (>3.0 mg/L), were calculated using Cox regression analysis adjusted for traditional cardiovascular disease risk factors and stratified by the presence of no, isolated subclinical (i.e., intermediate risk) or clinical CVD. Having both TS and TO abnormal compared to both normal was associated with cardiac mortality in the low risk group [HR 7.9, 95% CI 2.8–22.5, (p<0.001)]. In the high and intermediate risk groups, abnormal TS and TO ([HR 2.2, 95% CI 1.5–4.0, p=0.016] and [HR 2.7, 95% CI 1.2–5.9, p=0.012]), respectively, were also significantly associated with cardiac mortality. In contrast, elevated CRP was associated with increased cardiac mortality risk only in low risk individuals [HR 2.5, 95% CI 1.3–5.1, p=0.009]. In the low risk group, the c-statistic was 0.706 for the base model, 0.725 for the base model with CRP, and 0.767 for the base model with HRT. Conclusions Abnormal HRT independently adds to risk stratification of low, intermediate and high risk individuals but appears to add especially to the stratification of those considered at low risk. PMID:21134026

  10. An experimental study of high Rayleigh number and high Prandtl number Bénard convection

    NASA Astrophysics Data System (ADS)

    Weeraratne, Dayanthie; Manga, Michael

    1998-11-01

    We performed a set of 25 experiments using corn syrup with a temperature-dependent viscosity for Rayleigh numbers 10^4 < Ra < 10^8 and Prandtl numbers 10^3 < Pr < 10^6; viscosity is based on the average temperature at the top and bottom of the layer. As Ra increases, we observe a transition from steady to time-dependent flow at Ra=O(10^5). A second transition occurs at Ra=O(10^6) where large scale flow is gradually replaced by isolated rising and sinking plumes. Plumes have mushroom-shaped heads and continuous tails attached to their respective thermal boundary layers and decrease in radius with increasing Ra. Previous studies for Ra < O(10^5) find that the Nusselt number Nu = 0.197Ra^0.276. At Ra greater than O(10^7) we find that the Nu is below this trend. The Reynolds number Re = Ra^1/2/Pr ranges from O(10-1) to O(10^1) for these high Ra experiments; we attribute the reduced Nu to inertial effects which reduce both plume size and velocity.

  11. The High/Scope Report. Number Four.

    ERIC Educational Resources Information Center

    Silverman, Charles, Ed.

    This report provides articles on several topics related to the education of young children. In the introduction High/Scope President David P. Weikart suggests that public investment in preschool education is a wise and economically sound social policy. New studies of the long term effects of preschool are demonstrating the staying power of early…

  12. Phenotyping structural abnormalities in mouse embryos using high-resolution episcopic microscopy

    PubMed Central

    Weninger, Wolfgang J.; Geyer, Stefan H.; Martineau, Alexandrine; Galli, Antonella; Adams, David J.; Wilson, Robert; Mohun, Timothy J.

    2014-01-01

    The arrival of simple and reliable methods for 3D imaging of mouse embryos has opened the possibility of analysing normal and abnormal development in a far more systematic and comprehensive manner than has hitherto been possible. This will not only help to extend our understanding of normal tissue and organ development but, by applying the same approach to embryos from genetically modified mouse lines, such imaging studies could also transform our knowledge of gene function in embryogenesis and the aetiology of developmental disorders. The International Mouse Phenotyping Consortium is coordinating efforts to phenotype single gene knockouts covering the entire mouse genome, including characterising developmental defects for those knockout lines that prove to be embryonic lethal. Here, we present a pilot study of 34 such lines, utilising high-resolution episcopic microscopy (HREM) for comprehensive 2D and 3D imaging of homozygous null embryos and their wild-type littermates. We present a simple phenotyping protocol that has been developed to take advantage of the high-resolution images obtained by HREM and that can be used to score tissue and organ abnormalities in a reliable manner. Using this approach with embryos at embryonic day 14.5, we show the wide range of structural abnormalities that are likely to be detected in such studies and the variability in phenotypes between sibling homozygous null embryos. PMID:25256713

  13. Nicotine in Combination With a High-Fat Diet Causes Intramyocellular Mitochondrial Abnormalities in Male Mice

    PubMed Central

    Sinha-Hikim, Indrani; Friedman, Theodore C.; Shin, Chang-Sung; Lee, Desean; Ivey, Rasheed

    2014-01-01

    Smoking is a major risk factor for diabetes, cardiovascular disease, and nonalcoholic fatty liver disease. The health risk associated with smoking can be exaggerated by obesity. We hypothesize that nicotine when combined with a high-fat diet (HFD) can also cause ectopic lipid accumulation in skeletal muscle, similar to recently observed hepatic steatosis. Adult C57BL6 male mice were fed a normal chow diet or HFD and received twice-daily ip injections of nicotine (0.75 mg/kg body weight) or saline for 10 weeks. Transmission electron microscopy of the gastrocnemius muscle revealed substantial intramyocellular lipid accumulation in close association with intramyofibrillar mitochondria along with intramyofibrillar mitochondrial swelling and vacuolization in nicotine-treated mice on an HFD compared with mice on an HFD treated with saline. These abnormalities were reversed by acipimox, an inhibitor of lipolysis. Mechanistically, the detrimental effect of nicotine plus HFD on skeletal muscle was associated with significantly increased oxidative stress, plasma free fatty acid, and muscle triglyceride levels coupled with inactivation of AMP-activated protein kinase and activation of its downstream target, acetyl-coenzyme A-carboxylase. We conclude that 1) greater oxidative stress together with inactivation of AMP-activated protein kinase mediates the effect of nicotine on skeletal muscle abnormalities in diet-induced obesity and 2) adipose tissue lipolysis is an important contributor of muscle steatosis and mitochondrial abnormalities. PMID:24424058

  14. Mathematical impairment associated with high-contrast abnormalities in change detection and magnocellular visual evoked response.

    PubMed

    Jastrzebski, Nicola R; Crewther, Sheila G; Crewther, David P

    2015-10-01

    The cause of developmental dyscalculia, a specific deficit in acquisition of arithmetic skills, particularly of enumeration, has never been investigated with respect to the patency of the visual magnocellular system. Here, the question of dysfunction of the afferent magnocellular cortical input and its dorsal stream projections was tested directly using nonlinear analysis of the visual evoked potential (VEP) and through the psychophysical ability to rapidly detect visual change. A group of young adults with self-reported deficiencies of arithmetical ability, showed marked impairment in magnitude estimation and enumeration performance-though not in lexical decision reaction times when compared with an arithmetically capable group controlled for age and handedness. Multifocal nonlinear VEPs were recorded at low (24 %) and high (96 %) contrast. First- and second-order VEP kernels were comparable between groups at low contrast, but not at high contrast. The mathematically impaired group showed an abnormal lack of contrast saturation in the shortest latency first-order peak (N60) and a delayed P100 positivity in the first slice of the second-order kernel. Both features have previously been argued to be physiological markers of magnocellular function. Mathematically impaired participants also performed worse on a gap paradigm change detection for digit task showing increased reaction times for high-contrast stimuli but not for low-contrast stimuli compared with controls. The VEP results give direct evidence of abnormality in the occipital processing of magnocellular information in those with mathematical impairment. The anomalous high visual contrast physiological and psychophysical performance suggests an abnormality in the inhibitory processes that normally result in saturation of contrast gain in the magnocellular system. PMID:26195163

  15. Abnormal high surface heat flow caused by the Emeishan mantle plume

    NASA Astrophysics Data System (ADS)

    Jiang, Qiang; Qiu, Nansheng; Zhu, Chuanqing

    2016-04-01

    It is commonly believed that increase of heat flow caused by a mantle plume is small and transient. Seafloor heat flow data near the Hawaiian hotspot and the Iceland are comparable to that for oceanic lithosphere elsewhere. Numerical modeling of the thermal effect of the Parana large igneous province shows that the added heat flow at the surface caused by the magmatic underplating is less than 5mW/m2. However, the thermal effect of Emeishan mantle plume (EMP) may cause the surface hear-flow abnormally high. The Middle-Late Emeishan mantle plume is located in the western Yangtze Craton. The Sichuan basin, to the northeast of the EMP, is a superimposed basin composed of Paleozoic marine carbonate rocks and Mesozoic-Cenozoic terrestrial clastic rocks. The vitrinite reflectance (Ro) data as a paleogeothermal indicator records an apparent change of thermal regime of the Sichuan basin. The Ro profiles from boreholes and outcrops which are close to the center of the basalt province exhibit a 'dog-leg' style at the unconformity between the Middle and Upper Permian, and they show significantly higher gradients in the lower subsection (pre-Middle Permian) than the Upper subsection (Upper Permian to Mesozoic). Thermal history inversion based on these Ro data shows that the lower subsection experienced a heat flow peak much higher than that of the upper subsection. The abnormal heat flow in the Sichuan basin is consistent with the EMP in temporal and spatial distribution. The high-temperature magmas from deep mantle brought heat to the base of the lithosphere, and then large amount of heat was conducted upwards, resulting in the abnormal high surface heat flow.

  16. ACE Reduces Metabolic Abnormalities in a High-Fat Diet Mouse Model

    PubMed Central

    Lee, Seong-Jong; Han, Jong-Min; Lee, Jin-Seok; Son, Chang-Gue; Im, Hwi-Jin; Jo, Hyun-Kyung; Yoo, Ho-Ryong; Kim, Yoon-Sik; Seol, In-Chan

    2015-01-01

    The medicinal plants Artemisia iwayomogi (A. iwayomogi) and Curcuma longa (C. longa) radix have been used to treat metabolic abnormalities in traditional Korean medicine and traditional Chinese medicine (TKM and TCM). In this study we evaluated the effect of the water extract of a mixture of A. iwayomogi and C. longa (ACE) on high-fat diet-induced metabolic syndrome in a mouse model. Four groups of C57BL/6N male mice (except for the naive group) were fed a high-fat diet freely for 10 weeks. Among these, three groups (except the control group) were administered a high-fat diet supplemented with ACE (100 or 200 mg/kg) or curcumin (50 mg/kg). Body weight, accumulation of adipose tissues in abdomen and size of adipocytes, serum lipid profiles, hepatic steatosis, and oxidative stress markers were analyzed. ACE significantly reduced the body and peritoneal adipose tissue weights, serum lipid profiles (total cholesterol and triglycerides), glucose levels, hepatic lipid accumulation, and oxidative stress markers. ACE normalized lipid synthesis-associated gene expressions (peroxisome proliferator-activated receptor gamma, PPARγ; fatty acid synthase, FAS; sterol regulatory element-binding transcription factor-1c, SREBP-1c; and peroxisome proliferator-activated receptor alpha, PPARα). The results from this study suggest that ACE has the pharmaceutical potential reducing the metabolic abnormalities in an animal model. PMID:26508977

  17. Abnormal effective connectivity and psychopathological symptoms in the psychosis high-risk state

    PubMed Central

    Schmidt, André; Smieskova, Renata; Simon, Andor; Allen, Paul; Fusar-Poli, Paolo; McGuire, Philip K.; Bendfeldt, Kerstin; Aston, Jacqueline; Lang, Undine E.; Walter, Marc; Radue, Ernst-Wilhelm; Riecher-Rössler, Anita; Borgwardt, Stefan J.

    2014-01-01

    Background Recent evidence has revealed abnormal functional connectivity between the frontal and parietal brain regions during working memory processing in patients with schizophrenia and first-episode psychosis. However, it still remains unclear whether abnormal frontoparietal connectivity during working memory processing is already evident in the psychosis high-risk state and whether the connection strengths are related to psychopathological outcomes. Methods Healthy controls and antipsychotic-naive individuals with an at-risk mental state (ARMS) performed an n-back working memory task while undergoing functional magnetic resonance imaging. Effective connectivity between frontal and parietal brain regions during working memory processing were characterized using dynamic causal modelling. Results Our study included 19 controls and 27 individuals with an ARMS. In individuals with an ARMS, we found significantly lower task performances and reduced activity in the right superior parietal lobule and middle frontal gyrus than in controls. Furthermore, the working memory–induced modulation of the connectivity from the right middle frontal gyrus to the right superior parietal lobule was significantly reduced in individuals with an ARMS, while the extent of this connectivity was negatively related to the Brief Psychiatric Rating Scale total score. Limitations The modest sample size precludes a meaningful subgroup analysis for participants with a later transition to psychosis. Conclusion This study demonstrates that abnormal frontoparietal connectivity during working memory processing is already evident in individuals with an ARMS and is related to psychiatric symptoms. Thus, our results provide further insight into the pathophysiological mechanisms of the psychosis high-risk state by linking functional brain imaging, computational modelling and psychopathology. PMID:24506946

  18. Identification of copy-number abnormalities and inactivating mutations in two negative regulators of NF-kB signaling pathways in Waldenström’s Macroglobulinemia

    PubMed Central

    Braggio, Esteban; Keats, Jonathan J; Leleu, Xavier; Van Wier, Scott; Jimenez-Zepeda, Victor H; Valdez, Riccardo; Schop, Roelandt FJ; Price-Troska, Tammy; Henderson, Kimberly; Sacco, Antonio; Azab, Feda; Greipp, Philip; Gertz, Morie; Hayman, Suzanne; Rajkumar, S Vincent; Carpten, John; Chesi, Marta; Barrett, Michael; Stewart, A Keith; Dogan, Ahmet; Bergsagel, P Leif; Ghobrial, Irene M; Fonseca, Rafael

    2009-01-01

    Waldenström’s macroglobulinemia (WM) is a distinct clinico-biological entity defined as a B-cell neoplasm characterized by a lymphoplasmacytic infiltrate in the bone marrow (BM) and immunoglobulin M paraprotein production. Cytogenetic analyses were historically limited by the difficulty in obtaining tumor metaphases and the genetic basis of the disease remains poorly defined. Here we performed a comprehensive analysis in 42 WM patients by using high-resolution, array-based comparative genomic hybridization approach to unravel the genetic mechanisms associated with WM pathogenesis. Overall, 83% of patients have chromosomal abnormalities, with a median of three abnormalities per patient. Gain of 6p was the second most common abnormality (17%) and its presence was always concomitant with 6q loss. A minimal deleted region, including MIRN15A and MIRN16-1, was delineated on 13q14 in 10% of patients. Of interest, we reported biallelic deletions and/or inactivating mutations with uniparental disomy in TRAF3 and TNFAIP3, two negative regulators of the NF-kB signaling pathway. Furthermore, we confirmed the association between TRAF3 inactivation and increased transcriptional activity of NF-kB target genes. Mutational activation of the NF-kB pathway, which is normally activated by ligand-receptor interactions within the BM microenvironment, highlights its biologic importance, and suggests a therapeutic role for inhibitors of NF-kB pathway activation in the treatment of Waldenström’s macroglobulinemia. PMID:19351844

  19. Normal and abnormal evolution of argon metastable density in high-density plasmas

    SciTech Connect

    Seo, B. H.; Kim, J. H.; You, S. J.

    2015-05-15

    A controversial problem on the evolution of Ar metastable density as a function of electron density (increasing trend versus decreasing trend) was resolved by discovering the anomalous evolution of the argon metastable density with increasing electron density (discharge power), including both trends of the metastable density [Daltrini et al., Appl. Phys. Lett. 92, 061504 (2008)]. Later, by virtue of an adequate physical explanation based on a simple global model, both evolutions of the metastable density were comprehensively understood as part of the abnormal evolution occurring at low- and high-density regimes, respectively, and thus the physics behind the metastable evolution has seemed to be clearly disclosed. In this study, however, a remarkable result for the metastable density behavior with increasing electron density was observed: even in the same electron density regime, there are both normal and abnormal evolutions of metastable-state density with electron density depending on the measurement position: The metastable density increases with increasing electron density at a position far from the inductively coupled plasma antenna but decreases at a position close to the antenna. The effect of electron temperature, which is spatially nonuniform in the plasma, on the electron population and depopulation processes of Argon metastable atoms with increasing electron density is a clue to understanding the results. The calculated results of the global model, including multistep ionization for the argon metastable state and measured electron temperature, are in a good agreement with the experimental results.

  20. Left-Hemispheric Microstructural Abnormalities in Children With High Functioning Autism Spectrum Disorder

    PubMed Central

    Peterson, Daniel; Mahajan, Rajneesh; Crocetti, Deana; Mejia, Amanda; Mostofsky, Stewart

    2014-01-01

    Current theories of the neurobiological basis of Autism Spectrum Disorder (ASD) posit an altered pattern of connectivity in large-scale brain networks. Here we used Diffusion Tensor Imaging to investigate the microstructural properties of the white matter that mediates inter-regional connectivity in 36 high-functioning children with ASD (HF-ASD), as compared to 37 controls. By employing an atlas-based analysis using LDDMM registration, a widespread, but left-lateralized pattern of abnormalities was revealed. The Mean Diffusivity (MD) of water in the white matter of HF-ASD children was significantly elevated throughout the left hemisphere, particularly in the outer-zone cortical white matter. Across diagnostic groups there was a significant effect of age on left hemisphere MD, with a similar reduction in MD during childhood in both TD and HF-ASD children. The increased MD in children with HF-ASD suggests hypomyelination, and may reflect increased short-range cortico-cortical connections subsequent to early white matter overgrowth. These findings also highlight left hemispheric connectivity as relevant to the pathophysiology of ASD, and indicate that the spatial distribution of microstructural abnormalities in HF-ASD is widespread, and left-lateralized. This altered left-hemispheric connectivity may contribute to deficits in communication and praxis observed in ASD. PMID:25256103

  1. Diastolic Dysfunction Induced by a High-Fat Diet Is Associated with Mitochondrial Abnormality and Adenosine Triphosphate Levels in Rats

    PubMed Central

    Kang, Ki-Woon; Kim, Ok-Soon; Chin, Jung Yeon; Kim, Won Ho; Park, Sang Hyun; Choi, Yu Jeong; Shin, Jong Ho; Jung, Kyung Tae; Lim, Do-Seon

    2015-01-01

    Background Obesity is well-known as a risk factor for heart failure, including diastolic dysfunction. However, this mechanism in high-fat diet (HFD)-induced obese rats remain controversial. The purpose of this study was to investigate whether cardiac dysfunction develops when rats are fed with a HFD for 10 weeks; additionally, we sought to investigate the association between mitochondrial abnormalities, adenosine triphosphate (ATP) levels and cardiac dysfunction. Methods We examined myocardia in Wistar rats after 10 weeks of HFD (45 kcal% fat, n=6) or standard diet (SD, n=6). Echocardiography, histomorphologic analysis, and electron microscopy were performed. The expression levels of mitochondrial oxidative phosphorylation (OXPHOS) subunit genes, peroxisome-proliferator-activated receptor γ co-activator-1α (PGC1α) and anti-oxidant enzymes were assessed. Markers of oxidative stress damage, mitochondrial DNA copy number and myocardial ATP level were also examined. Results After 10 weeks, the body weight of the HFD group (349.6±22.7 g) was significantly higher than that of the SD group (286.8±14.9 g), and the perigonadal and epicardial fat weights of the HFD group were significantly higher than that of the SD group. Histomorphologic and electron microscopic images were similar between the two groups. However, in the myocardium of the HFD group, the expression levels of OXPHOS subunit NDUFB5 in complex I and PGC1α, and the mitochondrial DNA copy number were decreased and the oxidative stress damage marker 8-hydroxydeoxyguanosine was increased, accompanied by reduced ATP levels. Conclusion Diastolic dysfunction was accompanied by the mitochondrial abnormality and reduced ATP levels in the myocardium of 10 weeks-HFD-induced rats. PMID:26790384

  2. The integrated method to select drilling muds for abnormally high pressure formations

    NASA Astrophysics Data System (ADS)

    Khorev, V. S.; Dmitriev, A. Yu; Boyko, I. A.; Kayumova, N. S.; Rakhimov, T. R.

    2016-03-01

    The article describes the method for choosing a drilling mud for drilling abnormally high pressure formations. A carefully selected drilling mud formulation would not only enhance an array of interrelated fluid properties, but also minimize the impact on the pay zones when the drill bit first penetrates the pay. To ensure a better assessment of drilling mud impact on the pay zone, it is reasonable to carry out the study focused on the analysis of technological parameters, involving filtration, acid and drilling mud tests, as well as formation damage analysis. This would enable evaluating the degree of mudding off, reservoirs acid fracturing effect and the risks of pipe sticking at significant depth. The article presents the results of the above-described study with regard to the currently used drilling mud and new experimental formulations developed at National Research Tomsk Polytechnic University (Drilling Mud and Cement Slurry Laboratory).

  3. Dietary high-fat lard intake induces thyroid dysfunction and abnormal morphology in rats

    PubMed Central

    Shao, Shan-shan; Zhao, Yuan-fei; Song, Yong-feng; Xu, Chao; Yang, Jian-mei; Xuan, Shi-meng; Yan, Hui-li; Yu, Chun-xiao; Zhao, Meng; Xu, Jin; Zhao, Jia-jun

    2014-01-01

    Aim: Excess dietary fat intake can induce lipotoxicity in non-adipose tissues. The aim of this study was to observe the effects of dietary high-fat lard intake on thyroid in rats. Methods: Male Sprague-Dawley rats were fed a high-fat lard diet for 24 weeks, and then the rats were fed a normal control diet (acute dietary modification) or the high-fat lard diet for another 6 weeks. The serum lipid profile, total thyroxine (TT4), free thyroxine (FT4) and thyrotropin (TSH) levels were determined at the 12, 18, 24 and 30 weeks. High-frequency ultrasound scanning of the thyroid glands was performed at the 24 or 30 weeks. After the rats were sacrificed, the thyroid glands were collected for histological and immunohistochemical analyses. Results: The high-fat lard diet significantly increased triglyceride levels in both the serum and thyroid, and decreased serum TT4 and FT4 levels in parallel with elevated serum TSH levels. Ultrasonic imaging revealed enlarged thyroid glands with lowered echotexture and relatively heterogeneous features in the high-fat lard fed rats. The thyroid glands from the high-fat lard fed rats exhibited enlarged follicle cavities and flattened follicular epithelial cells under light microscopy, and dilated endoplasmic reticulum cisternae, twisted nuclei, fewer microvilli and secretory vesicles under transmission electron microscopy. Furthermore, the thyroid glands from the high-fat lard fed rats showed markedly low levels of thyroid hormone synthesis-related proteins TTF-1 and NIS. Acute dietary modification by withdrawal of the high-fat lard diet for 6 weeks failed to ameliorate the high-fat lard diet-induced thyroid changes. Conclusion: Dietary high-fat lard intake induces significant thyroid dysfunction and abnormal morphology in rats, which can not be corrected by short-term dietary modification. PMID:25263336

  4. Network Mechanisms Generating Abnormal and Normal Hippocampal High-Frequency Oscillations: A Computational Analysis1,2,3

    PubMed Central

    Gliske, Stephen; Catoni, Nicholas

    2015-01-01

    Abstract High-frequency oscillations (HFOs) are an intriguing potential biomarker for epilepsy, typically categorized according to peak frequency as either ripples (100–250 Hz) or fast ripples (>250 Hz). In the hippocampus, fast ripples were originally thought to be more specific to epileptic tissue, but it is still very difficult to distinguish which HFOs are caused by normal versus pathological brain activity. In this study, we use a computational model of hippocampus to investigate possible network mechanisms underpinning normal ripples, pathological ripples, and fast ripples. Our results unify several prior findings regarding HFO mechanisms, and also make several new predictions regarding abnormal HFOs. We show that HFOs are generic, emergent phenomena whose characteristics reflect a wide range of connectivity and network input. Although produced by different mechanisms, both normal and abnormal HFOs generate similar ripple frequencies, underscoring that peak frequency is unable to distinguish the two. Abnormal ripples are generic phenomena that arise when input to pyramidal cells overcomes network inhibition, resulting in high-frequency, uncoordinated firing. In addition, fast ripples transiently and sporadically arise from the precise conditions that produce abnormal ripples. Lastly, we show that such abnormal conditions do not require any specific network structure to produce coherent HFOs, as even completely asynchronous activity is capable of producing abnormal ripples and fast ripples in this manner. These results provide a generic, network-based explanation for the link between pathological ripples and fast ripples, and a unifying description for the entire spectrum from normal ripples to pathological fast ripples. PMID:26146658

  5. High frequency of p53/MDM2/p14ARF pathway abnormalities in relapsed neuroblastoma

    PubMed Central

    Carr-Wilkinson, Jane; O' Toole, Kieran; Wood, Katrina M.; Challen, Christine C.; Baker, Angela G.; Board, Julian R.; Evans, Laura; Cole, Michael; Cheung, Nai-Kong V.; Boos, Joachim; Köhler, Gabriele; Leuschner, Ivo; Pearson, Andrew D.J.; Lunec, John; Tweddle, Deborah A.

    2010-01-01

    Purpose: Most neuroblastomas initially respond to therapy but many relapse with chemoresistant disease. p53 mutations are rare in diagnostic neuroblastomas, but we have previously reported inactivation of the p53/MDM2/p14ARF pathway in 9/17 (53%) neuroblastoma cell lines established at relapse. Hypothesis: Inactivation of the p53/MDM2/p14ARF pathway develops during treatment and contributes to neuroblastoma relapse. Methods: Eighty-four neuroblastomas were studied from 41 patients with relapsed neuroblastoma including 38 paired neuroblastomas at different stages of therapy. p53 mutations were detected by automated sequencing, p14ARF methylation and deletion by methylation-specific PCR and duplex PCR respectively, and MDM2 amplification by fluorescent in-situ hybridisation. Results: Abnormalities in the p53 pathway were identified in 20/41(49%) cases. Downstream defects due to inactivating missense p53 mutations were identified in 6/41 (15%) cases, 5 following chemotherapy and/or at relapse and 1 at diagnosis, post chemotherapy and relapse. The presence of a p53 mutation was independently prognostic for overall survival (hazard ratio 3.4, 95% confidence interval 1.2, 9.9; p = 0.02). Upstream defects were present in 35% cases: MDM2 amplification in 3 cases, all at diagnosis & relapse and p14ARF inactivation in 12/41 (29%) cases: 3 had p14ARF methylation, 2 after chemotherapy, and 9 had homozygous deletions, 8 at diagnosis and relapse. Conclusions: These results show that a high proportion of neuroblastomas which relapse have an abnormality in the p53 pathway. The majority have upstream defects suggesting that agents which reactivate wild-type p53 would be beneficial, in contrast to those with downstream defects where p53 independent therapies are indicated. PMID:20145180

  6. Promoting Number Theory in High Schools or Birthday Problem and Number Theory

    ERIC Educational Resources Information Center

    Srinivasan, V. K.

    2010-01-01

    The author introduces the birthday problem in this article. This can amuse willing members of any birthday party. This problem can also be used as the motivational first day lecture in number theory for the gifted students in high schools or in community colleges or in undergraduate classes in colleges.

  7. Abnormal high-Q modes of coupled stadium-shaped microcavities.

    PubMed

    Ryu, Jung-Wan; Lee, Soo-Young; Kim, Inbo; Choi, Muhan; Hentschel, Martina; Kim, Sang Wook

    2014-07-15

    It is well known that the strongly deformed microcavity with fully chaotic ray dynamics cannot support high-Q modes due to its fast chaotic diffusion to the critical line of refractive emission. Here, we investigate how the Q factor is modified when two chaotic cavities are coupled, and show that some modes, whose Q factor is about 10 times higher than that of the corresponding single cavity, can exist. These abnormal high-Q modes are the result of an optimal combination of coupling and cavity geometry. As an example, in the coupled stadium-shaped microcavities, the mode pattern extends over both cavities such that it follows a whispering-gallery-type mode at both ends, whereas a big coupling spot forms at the closest contact of the two microcavities. The pattern of such a "rounded bow tie" mode allows the mode to have a high-Q factor. This mode pattern minimizes the leakage of light at both ends of the microcavities as the pattern at both ends is similar to the whispering gallery mode. PMID:25121685

  8. An experimental investigation of turbulent boundary layers at high Mach number and Reynolds numbers

    NASA Technical Reports Server (NTRS)

    Holden, M. S.

    1972-01-01

    Skin friction, heat transfer and pressure measurements were obtained in laminar, transitional and turbulent boundary layers on flat plates at Mach numbers from 7 to 13 at wall-to-free stream stagnation temperature ratios from 0.1 to 0.3. Measurements in laminar flows were in excellent agreement with the theory of Cheng. Correlations of the transition measurements with measurements on flight vehicles and in ballistic ranges show good agreement. Our transition measurements do not correlate well with those of Pate and Schueler. Comparisons have been made between the skin friction and heat transfer measurements and the theories of Van Driest, Eckert and Spalding and Chi. These comparisons reveal in general that at the high end of our Mach number range (10-13) the theory of Van Driest is in best agreement with the data, whereas at lower Mach numbers (6.5-10) the Spalding Chi theory is in better agreement with the measurements.

  9. Isolation and Characterization of an Abnormal High Density Lipoprotein in Tangier Disease

    PubMed Central

    Assmann, Gerd; Herbert, Peter N.; Fredrickson, Donald S.; Forte, Trudy

    1977-01-01

    The nature of the high density lipoproteins has been investigated in five patients homozygous for Tangier disease (familial high density lipoprotein deficiency). It has been established that Tangier high density lipoproteins, as isolated by ultracentrifugation, are morphologically heterogenous and contain several proteins (Apo B, albumin, and Apo A-II). An abnormal lipoprotein has been isolated from the d = 1.063-1.21 g/ml ultracentrifugal fraction by agarose-column chromatography which contains apoprotein A-II as the sole protein constituent. In negative-stain electron microscopy, these lipoproteins appeared as spherical particles 55-75 Å in diameter. By a variety of criteria (immunochemical, polyacrylamide electrophoresis, amino acid composition, and fluorescence measurements), apoprotein A-I the major apoprotein of normal high density lipoproteins and the C apoproteins were absent from this lipoprotein. As demonstrated by 125I very low density lipoprotein incubation experiments with Tangier plasma, C apoproteins did not associate with lipoproteins of d = 1.063-1.21 g/ml. Tangier apoprotein A-II, isolated to homogeneity by delipidation of the apoprotein A-II-containing lipoprotein or Sephadex G-200 guanidine-HCl chromatography of the d = 1.063-1.21 g/ml fraction, was indistinguishable from control apoprotein A-II with respect to amino acid composition and migration of tryptic peptides in urea-polyacrylamide electrophoresis. The ability of Tangier apoprotein A-II to bind phospholipid was demonstrated by in vitro reconstitution experiments and morphological and chemical analysis of lipid-protein complexes. It is concluded that normal high density lipoproteins, as defined by polypeptide composition and morphological appearance, are absent from Tangier plasma and that as a consequence, the impairment of C apoprotein metabolism contributes to the hypertriglyceridemia and fasting chylomicronemia observed in these patients. Images PMID:194920

  10. Abnormal Adrenal Responsiveness and Angiotensin II Dependency in High Renin Essential Hypertension

    PubMed Central

    Dluhy, Robert G.; Bavli, Sam Z.; Leung, Frank K.; Solomon, Harold S.; Moore, Thomas J.; Hollenberg, Norman K.; Williams, Gordon H.

    1979-01-01

    Adrenal responsiveness to angiotensin II (AII) and the diastolic blood pressure responses to saralasin were studied in 19 patients with high renin essential hypertension (HREH) on a 10-meq Na+/100 meq K+ diet. The increment in plasma renin activity (PRA) between supine and upright positions was used as an estimate of the acute stimulation of the adrenal gland by endogenous AII; the normal increment in plasma aldosterone divided by the increment in PRA was >3.8. 7 of 19 had abnormal upright posture responses with significantly greater mean PRA increments (24±6 ng/ml per h) and significantly smaller plasma aldosterone increments 47 ± 16 ng/dl) (P < 0.036) compared to the increments observed in HREH patients with normal adrenal responsiveness (PRA = 15 ± 1 ng/ml per h; plasma aldosterone = 87 ± 17 ng/dl). When AII was infused at doses of 0.1-3 ng/kg per min, only patients with normal posture responses had normal plasma aldosterone increments; plasma aldosterone levels failed to significantly increase even at the highest infusion rate in the patients with the abnormal upright posture responses. The AII competitive inhibitor, saralasin (0.3-30 μg/kg per min) was then infused to study the occurrence of angiotensinogenic hypertension in both HREH subgroups. The mean decline in diastolic blood pressure to saralasin in the subnormal adrenal responsive patients (−15 ± 3 mm Hg) was significantly greater than in the normal adrenal responsive group (−3 ± 2 mm Hg) (P < 0.02). It is concluded that patients with HREH are not a homogeneous population; approximately one-third have AII-dependent hypertension. In these patients, the mechanism responsible for the elevated renin and blood pressure could be a compensatory increase secondary to decreased adrenal responsiveness to AII. In the remainder, the high PRA levels have little, if any, causal role in the pathogenesis of the hypertension but could reflect a marker of other pathophysiologic processes. PMID:500810

  11. Wave phenomena in a high Reynolds number compressible boundary layer

    NASA Technical Reports Server (NTRS)

    Bayliss, A.; Maestrello, L.; Parikh, P.; Turkel, E.

    1985-01-01

    Growth of unstable disturbances in a high Reynolds number compressible boundary layer is numerically simulated. Localized periodic surface heating and cooling as a means of active control of these disturbances is studied. It is shown that compressibility in itself stabilizes the flow but at a lower Mach number, significant nonlinear distortions are produced. Phase cancellation is shown to be an effective mechanism for active boundary layer control.

  12. Age and sensory processing abnormalities predict declines in encoding and recall of temporally manipulated speech in high-functioning adults with ASD.

    PubMed

    Mayer, Jennifer L; Heaton, Pamela F

    2014-02-01

    While temporal and perceptual processing abnormalities, identified in a number of electrophysiological and brain imaging studies of individuals with (ASD), are likely to impact on speech perception, surprisingly little is known about the behavioral outcomes of such abnormalities. It has been hypothesized that rapid temporal processing deficits may be linked to impaired language development through interference with acoustic information during speech perception. The present study aimed to investigate the impact of temporal changes on encoding and recall of speech, and the associated cognitive, clinical, and behavioral correlates in adults with ASD. Research carried out with typically developing (TD) adults has shown that word recall diminishes as the speed of speech increases, and it was predicted that the magnitude of this effect would be far greater in those with ASD because of a preexisting rapid temporal processing deficit. Nineteen high-functioning adults with ASD, and age- and intelligence-matched TD controls performed verbatim recall of temporally manipulated sentences. Reduced levels of word recall in response to increases in presentation speed were observed, and this effect was greater in the older participants in the ASD group than in the control group. This is the first study to show that both sensory abnormalities and aging impact on speech encoding in ASD. Auditory processing deficits in ASD may be indicative of an association with the sensory abnormalities and social and communication impairments characterizing the disorder. PMID:24106132

  13. Reproductive and behavioral abnormalities in tree swallows with high levels of PCB contamination

    SciTech Connect

    McCarty, J.; Secord, A.; Tillitt, D.

    1995-12-31

    Tree Swallows (Tachycineta bicolor) breeding along the Hudson River forage extensively on PCB contaminated insects that emerge from the river. The authors studied the reproductive ecology and behavior of tree swallows breeding at several sites along the Hudson River. These sites vary in the severity of PCB contamination. PCB levels in both eggs and chicks were found to be among the highest ever reported in this species, with concentrations comparable to those found in aquatic organisms in the Hudson River. In 1994 reproductive success at PCB contaminated sites was significantly impaired, relative to other sites in New York. Reduced reproductive success was largely attributed to high levels of nest abandonment during incubation and reduced hatchability of eggs. Growth and development of nestlings was not significantly impaired. Abnormal nest building behavior was also noted in 1994, and this was studied in detail in 1995. Nests from contaminated areas are significantly smaller than those at a nearby reference site and at other sites in New York. The authors suggest that the reduced reproductive outputs at these sites are, in large part, a result of effects on the behavior of incubating females. The population-level implications of these patterns are unknown.

  14. Enthalpy damping for high Mach number Euler solutions

    NASA Technical Reports Server (NTRS)

    Moitra, Anutosh

    1990-01-01

    An improvement on the enthalpy damping procedure currently in use in solving supersonic flow fields is described. A correction based on entropy values is shown to produce a very efficient scheme for simulation of high Mach number three-dimensional flows. Substantial improvements in convergence rates have been achieved by incorporating this enthalpy damping scheme in a finite-volume Runge-Kutta method for solving the Euler equations. Results obtained for blended wing-body geometries at very high Mach numbers are presented.

  15. Vorticity transformation in high Karlovitz number premixed flames

    NASA Astrophysics Data System (ADS)

    Bobbitt, Brock; Lapointe, Simon; Blanquart, Guillaume

    2016-01-01

    To better understand the two-way coupling between turbulence and chemistry, the changes in turbulence characteristics through a premixed flame are investigated. Specifically, this study focuses on vorticity, ω, which is characteristic of the smallest length and time scales of turbulence, analyzing its behavior within and across high Karlovitz number (Ka) premixed flames. This is accomplished through a series of direct numerical simulations (DNS) of premixed n-heptane/air flames, modeled with a 35-species finite-rate chemical mechanism, whose conditions span a wide range of unburnt Karlovitz numbers and flame density ratios. The behavior of the terms in the enstrophy, ω2 = ω ṡ ω, transport equation is analyzed, and a scaling is proposed for each term. The resulting normalized enstrophy transport equation involves only a small set of parameters. Specifically, the theoretical analysis and DNS results support that, at high Karlovitz number, enstrophy transport obtains a balance of the viscous dissipation and production/vortex stretching terms. It is shown that, as a result, vorticity scales in the same manner as in homogeneous, isotropic turbulence within and across the flame, namely, scaling with the inverse of the Kolmogorov time scale, τη. As τη is a function only of the viscosity and dissipation rate, this work supports the validity of Kolmogorov's first similarity hypothesis in premixed turbulent flames for sufficiently high Ka numbers. Results are unaffected by the transport model, chemical model, turbulent Reynolds number, and finally the physical configuration.

  16. High Reynolds Number and Turbulence Effects on Turbine Heat Transfer

    NASA Technical Reports Server (NTRS)

    Yeh, Frederick C.; Hippensteele, Steven A.; vanFossen, G. James; Poinsatte, Philip E.; Ameri, Ali

    1994-01-01

    Experimental data on pressure distribution and heat transfer on a turbine airfoil were obtained over a range of Reynolds numbers from 0.75 to 7.0 x 10(exp 6) and a range of turbulence intensities from 1.8 to about 15%. The purpose of this study was to obtain fundamental heat transfer and pressure distribution data over a wide range of high Reynolds numbers and to extend the heat transfer data base to include the range or Reynolds numbers encountered in the Space Shuttle main engine turbopump turbines. The results of this study indicated that Reynolds number and turbulence intensity have a large effect on both the transition from laminar to turbulent flow and the resulting heat transfer. For a given turbulence intensity, heat transfer for all Reynolds numbers at the leading edge can generally be correlated with the Frossling number developed for lower Reynolds numbers. For a given turbulence intensity, heat transfer for the airfoil surfaces downstream of the leading edge can be approximately correlated with a dimensionless parameter. Comparisons of the experimental results were also made with a numerical solution from a two-dimensional Navier-Stokes code.

  17. Probability density distribution of velocity differences at high Reynolds numbers

    NASA Technical Reports Server (NTRS)

    Praskovsky, Alexander A.

    1993-01-01

    Recent understanding of fine-scale turbulence structure in high Reynolds number flows is mostly based on Kolmogorov's original and revised models. The main finding of these models is that intrinsic characteristics of fine-scale fluctuations are universal ones at high Reynolds numbers, i.e., the functional behavior of any small-scale parameter is the same in all flows if the Reynolds number is high enough. The only large-scale quantity that directly affects small-scale fluctuations is the energy flux through a cascade. In dynamical equilibrium between large- and small-scale motions, this flux is equal to the mean rate of energy dissipation epsilon. The pdd of velocity difference is a very important characteristic for both the basic understanding of fully developed turbulence and engineering problems. Hence, it is important to test the findings: (1) the functional behavior of the tails of the probability density distribution (pdd) represented by P(delta(u)) is proportional to exp(-b(r) absolute value of delta(u)/sigma(sub delta(u))) and (2) the logarithmic decrement b(r) scales as b(r) is proportional to r(sup 0.15) when separation r lies in the inertial subrange in high Reynolds number laboratory shear flows.

  18. Nonadiabatic electron heating at high-Mach-number perpendicular shocks

    NASA Technical Reports Server (NTRS)

    Tokar, R. L.; Aldrich, C. H.; Forslund, D. W.; Quest, K. B.

    1986-01-01

    Fully kinetic simulations of high-Mach-number (HMN) perpendicular collisionless shocks are described. It is shown that electron acceleration in the cross-shock electron field can produce downstream electron temperature significantly higher than those expected for adiabatic compression. The momentum space for test electrons at Mach 6 is illustrated.

  19. Wire-number effects on high-power annular z-pinches and some characteristics at high wire number

    SciTech Connect

    SANFORD,THOMAS W. L.

    2000-05-23

    Characteristics of annular wire-array z-pinches as a function of wire number and at high wire number are reviewed. The data, taken primarily using aluminum wires on Saturn are comprehensive. The experiments have provided important insights into the features of wire-array dynamics critical for high x-ray power generation, and have initiated a renaissance in z-pinches when high numbers of wires are used. In this regime, for example, radiation environments characteristic of those encountered during the early pulses required for indirect-drive ICF ignition on the NIF have been produced in hohlraums driven by x-rays from a z-pinch, and are commented on here.

  20. High prevalence of anterolateral ligament abnormalities in magnetic resonance images of anterior cruciate ligament-injured knees.

    PubMed

    Claes, Steven; Bartholomeeusen, Stijn; Bellemans, Johan

    2014-03-01

    The purpose of this study was to identify the newly described anterolateral ligament of the human knee on magnetic resonance imaging and to describe its eventual radiological abnormalities in anterior cruciate ligament-injured subjects. A retrospective cohort study on a series of consecutive subjects undergoing anterior cruciate ligament reconstructive surgery was performed. The MR images of 206 included knees were studied and the status of the anterolateral ligament status was judged to be either "non-visualized", "normal" or "abnormal". Of all the visualized anterolateral ligaments, 44 (21.3%) were considered uninjured, while 162 (78.8%) knees demonstrated radiological ALL abnormalities. The majority of ALL abnormalities were situated in the distal part of the ligament (77.8%). In conclusion, the anterolateral ligament can be identified on classic knee magnetic resonance images. Although anterior cruciate ligament injured subjects often demonstrated associated anterolateral ligament lesions, further research is needed in order to establish the clinical relevance of these highly frequent radiological abnormalities. PMID:24873084

  1. Aerodynamic and acoustic performance of high Mach number inlets

    NASA Technical Reports Server (NTRS)

    Lumsdaine, E.; Clark, L. R.; Cherng, J. C.; Tag, I.

    1977-01-01

    Experimental results were obtained for two types of high Mach number inlets, one with a translating centerbody and one with a fixed geometry (collapsing cowl) without centerbody. The aerodynamic and acoustic performance of these inlets was examined. The effects of several parameters such as area ratio and length-diameter ratio were investigated. The translating centerbody inlet was found to be superior to the collapsing cowl inlet both acoustically and aerodynamically, particularly for area ratios greater than 1.5. Comparison of length-diameter ratio and area ratio effects on performance near choked flow showed the latter parameter to be more significant. Also, greater high frequency noise attenuation was achieved by increasing Mach number from low to high subsonic values.

  2. Numerical solution of compressible viscous flows at high Reynolds numbers

    NASA Technical Reports Server (NTRS)

    Maccormack, R. W.

    1981-01-01

    A new numerical method which was used to reduce the computation time required in fluid dynamics to solve the Navier-Stokes equations at flight Reynolds numbers is described. The method is the implicit analogue of the explicit finite different method. It uses this as its first stage, while the second stage removes the restrictive stability condition by recasting the difference equations in an implicit form. The resulting matrix equations to be solved are either upper or lower block bidiagonal equations. The new method makes it possible and practical to calculate many important three dimensional, high Reynolds number flow fields on computers.

  3. Very high Mach number shocks - Theory. [in space plasmas

    NASA Technical Reports Server (NTRS)

    Quest, Kevin B.

    1986-01-01

    The theory and simulation of collisionless perpendicular supercritical shock structure is reviewed, with major emphasis on recent research results. The primary tool of investigation is the hybrid simulation method, in which the Newtonian orbits of a large number of ion macroparticles are followed numerically, and in which the electrons are treated as a charge neutralizing fluid. The principal results include the following: (1) electron resistivity is not required to explain the observed quasi-stationarity of the earth's bow shock, (2) the structure of the perpendicular shock at very high Mach numbers depends sensitively on the upstream value of beta (the ratio of the thermal to magnetic pressure) and electron resistivity, (3) two-dimensional turbulence will become increasingly important as the Mach number is increased, and (4) nonadiabatic bulk electron heating will result when a thermal electron cannot complete a gyrorbit while transiting the shock.

  4. Turbulence measurements in high Reynolds number boundary layers

    NASA Astrophysics Data System (ADS)

    Vallikivi, Margit; Smits, Alexander

    2013-11-01

    Measurements are conducted in zero pressure gradient turbulent boundary layers for Reynolds numbers from Reθ = 9,000 to 225,000. The experiments were performed in the High Reynolds number Test Facility (HRTF) at Princeton University, which uses compressed air as the working fluid. Nano-Scale Thermal Anemometry Probes (NSTAPs) are used to acquire data with very high spatial and temporal precision. These new data are used to study the scaling behavior of the streamwise velocity fluctuations in the boundary layer and make comparisons with the scaling of other wall-bounded turbulent flows. Supported under ONR Grant N00014-09-1-0263 (program manager Ron Joslin) and NSF Grant CBET-1064257 (program manager Henning Winter).

  5. High Reynolds Number Transition Experiments in ETW (TELFONA project)

    NASA Astrophysics Data System (ADS)

    Perraud, J.; Archambaud, J.-P.; Schrauf, G.; Donelli, R. S.; Hanifi, A.; Quest, J.; Hein, S.; Streit, T.; Fey, U.; Egami, Y.

    A wind-tunnel experiment on laminar-turbulent transition has been performed in ETW (the European Transonic Wind Tunnel in Koln) at high Reynolds number and cryogenic conditions. The studied geometry is a sting mounted full model in swept-wing configuration. The transition location was determined by means of Temperature Sensitive Paint (CryoTSP). The experimental observations were further analysed using different transition prediction tools, based on linear stability theory.

  6. Numerical Simulation of a High Mach Number Jet Flow

    NASA Technical Reports Server (NTRS)

    Hayder, M. Ehtesham; Turkel, Eli; Mankbadi, Reda R.

    1993-01-01

    The recent efforts to develop accurate numerical schemes for transition and turbulent flows are motivated, among other factors, by the need for accurate prediction of flow noise. The success of developing high speed civil transport plane (HSCT) is contingent upon our understanding and suppression of the jet exhaust noise. The radiated sound can be directly obtained by solving the full (time-dependent) compressible Navier-Stokes equations. However, this requires computational storage that is beyond currently available machines. This difficulty can be overcome by limiting the solution domain to the near field where the jet is nonlinear and then use acoustic analogy (e.g., Lighthill) to relate the far-field noise to the near-field sources. The later requires obtaining the time-dependent flow field. The other difficulty in aeroacoustics computations is that at high Reynolds numbers the turbulent flow has a large range of scales. Direct numerical simulations (DNS) cannot obtain all the scales of motion at high Reynolds number of technological interest. However, it is believed that the large scale structure is more efficient than the small-scale structure in radiating noise. Thus, one can model the small scales and calculate the acoustically active scales. The large scale structure in the noise-producing initial region of the jet can be viewed as a wavelike nature, the net radiated sound is the net cancellation after integration over space. As such, aeroacoustics computations are highly sensitive to errors in computing the sound sources. It is therefore essential to use a high-order numerical scheme to predict the flow field. The present paper presents the first step in a ongoing effort to predict jet noise. The emphasis here is in accurate prediction of the unsteady flow field. We solve the full time-dependent Navier-Stokes equations by a high order finite difference method. Time accurate spatial simulations of both plane and axisymmetric jet are presented. Jet Mach

  7. Wall-bounded turbulence at high Reynolds numbers

    NASA Astrophysics Data System (ADS)

    Vallikivi, Margit

    Measurements are reported that give new insight into the behavior of turbulent wall-bounded flows at high Reynolds number. Turbulent pipe and boundary layer flows are examined experimentally over a wide range of Reynolds numbers -- up to Retau=100,000 (Re D=6x106) in pipe flow, and up to Re tau=73,000 (ReD=235x103) in a flat plate zero pressure gradient boundary layer. A Nano-Scale Thermal Anemometry Probe (NSTAP) was developed for very high spatial and temporal resolution measurements. Sensors with wire lengths 30 and 60 mum were fabricated, tested and validated in known flows, and then used to obtain single-point measurements at high Reynolds numbers in pipe and boundary layers. The mean velocity data together with data from previous studies and extensive error analysis showed that the von Karman's constant in the log-law is kappa=0.40+/-0.02. It was shown that the streamwise Reynolds stress exhibits a logarithmic behavior in the inertial sublayer for Retau≥20,000, in both pipes and boundary layers. Variances as well as higher order even moments were compared for pipes and boundary layers and it was shown that all even moments have a logarithmic behavior in the inertial sublayer, suggesting a true scale separation. Streamwise turbulent spectra showed a clear k --5/3 region for up to two decades in wavenumber. No k--1 region was found to be present in any of the cases in the pipe or the boundary layer. The location of the outer spectral peak, associated with very large scale motions, was found to have only a weak dependence on Reynolds number. The loci of these peak occur at the same wall-normal distance where the streamwise stresses establish a logarithmic behavior and where the amplitude modulation coefficient has a zero value. This suggests that with Reynolds number increasing to infinity most of the energy is contained within a diminishing wall-layer in physical coordinates.

  8. Reynolds Number Effects at High Angles of Attack

    NASA Technical Reports Server (NTRS)

    Fisher, David F.; Cobleigh, Brent R.; Banks, Daniel W.; Hall, Robert M.; Wahls, Richard A.

    1998-01-01

    Lessons learned from comparisons between ground-based tests and flight measurements for the high-angle-of-attack programs on the F-18 High Alpha Research Vehicle (HARV), the X-29 forward-swept wing aircraft, and the X-31 enhanced fighter maneuverability aircraft are presented. On all three vehicles, Reynolds number effects were evident on the forebodies at high angles of attack. The correlation between flight and wind tunnel forebody pressure distributions for the F-18 HARV were improved by using twin longitudinal grit strips on the forebody of the wind-tunnel model. Pressure distributions obtained on the X-29 wind-tunnel model at flight Reynolds numbers showed excellent correlation with the flight data up to alpha = 50 deg. Above (alpha = 50 deg. the pressure distributions for both flight and wind tunnel became asymmetric and showed poorer agreement, possibly because of the different surface finish of the model and aircraft. The detrimental effect of a very sharp nose apex was demonstrated on the X-31 aircraft. Grit strips on the forebody of the X-31 reduced the randomness but increased the magnitude of the asymmetry. Nose strakes were required to reduce the forebody yawing moment asymmetries and the grit strips on the flight test noseboom improved the aircraft handling qualities.

  9. A moving frame algorithm for high Mach number hydrodynamics

    NASA Astrophysics Data System (ADS)

    Trac, Hy; Pen, Ue-Li

    2004-07-01

    We present a new approach to Eulerian computational fluid dynamics that is designed to work at high Mach numbers encountered in astrophysical hydrodynamic simulations. Standard Eulerian schemes that strictly conserve total energy suffer from the high Mach number problem and proposed solutions to additionally solve the entropy or thermal energy still have their limitations. In our approach, the Eulerian conservation equations are solved in an adaptive frame moving with the fluid where Mach numbers are minimized. The moving frame approach uses a velocity decomposition technique to define local kinetic variables while storing the bulk kinetic components in a smoothed background velocity field that is associated with the grid velocity. Gravitationally induced accelerations are added to the grid, thereby minimizing the spurious heating problem encountered in cold gas flows. Separately tracking local and bulk flow components allows thermodynamic variables to be accurately calculated in both subsonic and supersonic regions. A main feature of the algorithm, that is not possible in previous Eulerian implementations, is the ability to resolve shocks and prevent spurious heating where both the pre-shock and post-shock fluid are supersonic. The hybrid algorithm combines the high-resolution shock capturing ability of the second-order accurate Eulerian TVD scheme with a low-diffusion Lagrangian advection scheme. We have implemented a cosmological code where the hydrodynamic evolution of the baryons is captured using the moving frame algorithm while the gravitational evolution of the collisionless dark matter is tracked using a particle-mesh N-body algorithm. Hydrodynamic and cosmological tests are described and results presented. The current code is fast, memory-friendly, and parallelized for shared-memory machines.

  10. High Order Difference Method for Low Mach Number Aeroacoustics

    NASA Technical Reports Server (NTRS)

    Mueller, B.; Yee, H. C.; Mansour, Nagi (Technical Monitor)

    2001-01-01

    A high order finite difference method with improved accuracy and stability properties for computational aeroacoustics (CAA) at low Mach numbers is proposed. The Euler equations are split into a conservative and a symmetric non- conservative portion to allow the derivation of a generalized energy estimate. Since the symmetrization is based on entropy variables, that splitting of the flux derivatives is referred to as entropy splitting. Its discretization by high order central differences was found to need less numerical dissipation than conventional conservative schemes. Owing to the large disparity of acoustic and stagnation quantities in low Mach number aeroacoustics, the split Euler equations are formulated in perturbation form. The unknowns are the small changes of the conservative variables with respect to their large stagnation values. All nonlinearities and the conservation form of the conservative portion of the split flux derivatives can be retained, while cancellation errors are avoided with its discretization opposed to the conventional conservative form. The finite difference method is third-order accurate at the boundary and the conventional central sixth-order accurate stencil in the interior. The difference operator satisfies the summation by parts property analogous to the integration by parts in the continuous energy estimate. Thus, strict stability of the difference method follows automatically. Spurious high frequency oscillations are suppressed by a characteristic-based filter similar to but without limiter. The time derivative is approximated by a 4-stage low-storage second-order explicit Runge-Kutta method. The method has been applied to simulate vortex sound at low Mach numbers. We consider the Kirchhoff vortex, which is an elliptical patch of constant vorticity rotating with constant angular frequency in irrotational flow. The acoustic pressure generated by the Kirchhoff vortex is governed by the 2D Helmholtz equation, which can be solved

  11. Implicit turbulence modeling for high reynolds number flows.

    SciTech Connect

    Margolin, L. G.; Smolarkiewicz, P. K.; Wyszogrodzki, A. A.

    2001-01-01

    We continue our investigation of the implicit turbulence modeling property of the nonoscillatory finite volume scheme MPDATA. We start by comparing MPDATA simulations of decaying turbulence in a triply periodic cube with analogous pseudospectral studies. In the regime of direct numerical simulation, MPDATA is shown to agree closely with the pseudospectral model. As viscosity is reduced, the two model results diverge. We study the MPDATA results in the inviscid limit, using a combination of mathematical analysis and computational experiment. We validate the inviscid MPDATA results as representing the turbulent flow in the limit of very high Reynolds number.

  12. Wave phenomena in a high Reynolds number compressible boundary layer

    NASA Technical Reports Server (NTRS)

    Bayliss, A.; Maestrello, L.; Parikh, P.; Turkel, E.

    1987-01-01

    The behavior of spatially unstable waves in a high Reynolds number compressible laminar boundary layer is investigated by solution of the laminar two-dimensional compressible Navier-Stokes equations (solved to fourth-order accuracy) over a flat plate with a fluctuating disturbance generated at the inflow. A significant nonlinear distortion is produced, in qualitative agreement with experimental data. It is shown that increasing compressibility can significantly stabilize the flow over a flat plate, and that the mechanism of phase cancellation is a viable mechanism for the control of growing disturbances.

  13. Local isotropy in high Reynolds number turbulent shear flows

    NASA Technical Reports Server (NTRS)

    Saddoughi, Seyed G.

    1993-01-01

    This is a report on the continuation of experiments, which Dr. Srinivas Veeravalli and the present author started in 1991, to investigate the hypothesis of local isotropy in shear flows. This hypothesis, which states that at sufficiently high Reynolds numbers the small-scale structures of turbulent motions are independent of large-scale structures and mean deformations, has been used in theoretical studies of turbulence and computational methods like large-eddy simulation. The importance of Kolmogorov's ideas arises from the fact that they create a foundation for turbulence theory.

  14. Axisymmetric bubble pinch-off at high Reynolds numbers.

    PubMed

    Gordillo, J M; Sevilla, A; Rodríguez-Rodríguez, J; Martínez-Bazán, C

    2005-11-01

    Analytical considerations and potential-flow numerical simulations of the pinch-off of bubbles at high Reynolds numbers reveal that the bubble minimum radius, rn, decreases as tau proportional to r2n sqrt[1lnr2n], where tau is the time to break up, when the local shape of the bubble near the singularity is symmetric. However, if the gas convective terms in the momentum equation become of the order of those of the liquid, the bubble shape is no longer symmetric and the evolution of the neck changes to a rn proportional to tau1/3 power law. These findings are verified experimentally. PMID:16383983

  15. Anisotropic Structure of Rotating Homogeneous Turbulence at High Reynolds Numbers

    NASA Technical Reports Server (NTRS)

    Cambon, Claude; Mansour, Nagi N.; Squires, Kyle D.; Rai, Man Mohan (Technical Monitor)

    1995-01-01

    Large eddy simulation is used to investigate the development of anisotropies and the evolution towards a quasi two-dimensional state in rotating homogeneous turbulence at high Reynolds number. The present study demonstrates the existence of two transitions in the development of anisotropy. The first transition marks the onset of anisotropy and occurs when a macro-Rossby number (based on a longitudinal integral lengthscale) has decreased to near unity while the second transition occurs when a micro-Rossby number (defined in this work as the ratio of the rms fluctuating vorticity to background vorticity) has decreased to unity. The anisotropy marked by the first transition corresponds to a reduction in dimensionality while the second transition corresponds to a polarization of the flow, i.e., relative dominance of the velocity components in the plane normal to the rotation axis. Polarization is reflected by emergence of anisotropy measures based on the two-dimensional component of the turbulence. Investigation of the vorticity structure shows that the second transition is also characterized by an increasing tendency for alignment between the fluctuating vorticity vector and the background angular velocity vector with a preference for corrotative vorticity.

  16. Simulations of high Mach number perpendicular shocks with resistive electrons

    NASA Technical Reports Server (NTRS)

    Quest, K. B.

    1986-01-01

    A simulation code which models the ions as microparticles and the electrons as a resistive massless fluid is employed to study the structure of high Mach number perpendicular shocks. It is found that stable stationary shock solutions can be obtained for Alfven Mach numbers (M sub A) between 5 and 60 for upstream plasmas where the ratio of the plasma pressure to the magnetic pressure is 1, providing that the upstream resistive diffusion length is much smaller than the ion inertial length. For much larger resistive diffusion lengths, the magnetic field overshoot is damped, and the imbalance in the electron momentum equation results in a periodic fluctuation of the fraction of reflected ions. In the limit of M sub A of less than 10, the magnetic overshoot and the fraction of reflected ions increase with increasing M sub A, while at higher Mach numbers the fraction of reflected ions peaks at about 40 percent and the magnetic field overshoot increases at a much slower rate. Electron inertial effects are also considered.

  17. Resistance of plates and pipes at high Reynolds numbers

    NASA Technical Reports Server (NTRS)

    Schiller, L; Hermann, R

    1931-01-01

    It was learned that the law of resistance for high R values does not follow the simple powers, and that the powers, which can be obtained approximately for the velocity distribution, gradually change. Since, moreover, very important investigations have recently been made on the resistance of plates at very high R values, it seemed of interest to apply the above line of reasoning to the new general law of resistance. For this purpose, the resistance and velocity distribution along the plate must always be equal to the values of the pipe flow at the corresponding Reynolds number. We made two kinds of calculations, of which the one given here is the simpler and more practical and also agrees better with the experimental results.

  18. Octane number requirements of vehicles at high altitude

    SciTech Connect

    Callison, J.C.

    1987-01-01

    Past tests of vehicles show that their octane number requirements decrease with altitude. As a result, gasoline marketers sell lower-octane-number(ON) gasoline in the mountain states and other high-altitude areas. The current ASTM specifications, which allow reduction of gasoline octane of 1.0 to 1.5 ON per thousand feet, are based on CRC test programs run on 1967 to 1972 model vehicles. However, many new vehicles are now equipped with sophisticated electronic engine systems for control of emissions and improvement of performance and fuel economy at all altitudes. Because these new systems could minimize the altitude effect on octane requirement, Amoco Oil tested twelve 1984-1986 model cars and light trucks. The authors found their ON requirements were reduced on average about 0.2 ON per thousand feet on an (R+M)/2 basis (RMON/1,000 feet). The authors expect octane demand on gasoline suppliers in high-altitude areas to increase as these new cars make up a larger part of the vehicle population, and this could raise the cost of gasoline.

  19. Meiotic abnormalities

    SciTech Connect

    1993-12-31

    Chapter 19, describes meiotic abnormalities. These include nondisjunction of autosomes and sex chromosomes, genetic and environmental causes of nondisjunction, misdivision of the centromere, chromosomally abnormal human sperm, male infertility, parental age, and origin of diploid gametes. 57 refs., 2 figs., 1 tab.

  20. Stratified wakes, the high Froude number approximation, and potential flow

    NASA Astrophysics Data System (ADS)

    Vasholz, David P.

    2011-12-01

    Properties of a steady wake generated by a body moving uniformly at constant depth through a stratified fluid are studied as a function of two parameters inserted into the linearized equations of motion. The first parameter, μ, multiplies the along-track gradient term in the source equation. When formal solutions for an arbitrary buoyancy frequency profile are written as eigenfunction expansions, one finds that the limit μ → 0 corresponds to a high Froude number approximation accompanied by a substantial reduction in the complexity of the calculation. For μ = 1, upstream effects are present and the eigenvalues correspond to critical speeds above which transverse waves disappear for any given mode. For sufficiently high modes, the high Froude number approximation is valid. The second tracer multiplies the square of the buoyancy frequency term in the linearized conservation of mass equation and enables direct comparisons with the limit of potential flow. Detailed results are given for the simplest possible profile, in which the buoyancy frequency is independent of depth; emphasis is placed upon quantities that can, in principle, be experimentally measured in a laboratory experiment. The vertical displacement field is written in terms of a stratified wake form factor {{H}} , which is the sum of a wavelike contribution that is non-zero downstream and an evanescent contribution that appears symmetrically upstream and downstream. First- and second-order cross-track moments of {{H}} are analyzed. First-order results predict enhanced upstream vertical displacements. Second-order results expand upon previous predictions of wavelike resonances and also predict evanescent resonance effects.

  1. Inversion of the western Pacific subtropical high dynamic model and analysis of dynamic characteristics for its abnormality

    NASA Astrophysics Data System (ADS)

    Hong, M.; Zhang, R.; Li, J. X.; Ge, J. J.; Liu, K. F.

    2013-02-01

    Based on time series data of 500 hPa potential field from NCEP/NCAR (National Center for Environmental Forecast of American/National Center for Atmospheric Research), a novel consideration of empirical orthogonal function (EOF) time-space separation and dynamic system reconstruction for time series is introduced. This method consists of two parts: first, the dynamical model inversion and model parameter optimization are carried out on the EOF time coefficient series using the genetic algorithm (GA), and, second, a nonlinear dynamic model representing the subtropical high (SH) activity and its abnormality is established. The SH activity and its abnormal mechanism is studied using the developed dynamical model. Results show that the configuration and diversification of the SH equilibriums have good correspondence with the actual short-medium term abnormal activity of the SH. Change of SH potential field brought by the combination of equilibriums is more complex than that by mutation, and their exhibition patterns are different. The mutation behavior from high-value to low-value equilibriums of the SH in summer corresponds with the southward drop of the SH in the observed weather process. The combination behavior of the two steady equilibriums corresponds with disappearance of the "double-ridge" phenomenon of the SH. Dynamical mechanisms of these phenomena are explained.

  2. High consumption of pulses is associated with lower risk of abnormal glucose metabolism in women in Mauritius

    PubMed Central

    Wennberg, M.; Söderberg, S.; Uusitalo, U.; Tuomilehto, J.; Shaw, J. E.; Zimmet, P. Z.; Kowlessur, S.; Pauvaday, V.; Magliano, D. J.

    2014-01-01

    Aims To investigate if consumption of pulses was associated with a reduced risk of developing abnormal glucose metabolism, increases in body weight and increases in waist circumference in a multi-ethnic cohort in Mauritius. Methods Population-based surveys were performed in Mauritius in 1992 and in 1998. Pulse consumption was estimated from a food frequency questionnaire in 1992 and outcomes were measured in 1998. At both time points, anthropometry was undertaken and an oral glucose tolerance test was performed. Results Mauritian women with the highest consumption of pulses (highest tertile) had a reduced risk of developing abnormal glucose metabolism [odds ratio 0.52; 95% CI 0.27, 0.99) compared with those with the lowest consumption, and also after multivariable adjustments. In women, a high consumption of pulses was associated with a smaller increase in BMI. Conclusions High consumption of pulses was associated with a reduced risk of abnormal glucose metabolism and a smaller increase in BMI in Mauritian women. Promotion of pulse consumption could be an important dietary intervention for the prevention of Type 2 diabetes and obesity in Mauritius and should be examined in other populations and in clinical trials. PMID:25346062

  3. Evaluation of the Generalizability of the Number of Abnormal Scores and the Overall Test Battery Mean as Measures of Performance Validity to a Different Test Battery.

    PubMed

    Silk-Eglit, Graham M; Miele, Andrea S; Stenclik, Jessica H; Lynch, Julie K; McCaffrey, Robert J

    2015-01-01

    Davis, Axelrod, McHugh, Hanks, and Millis (2013) documented that in a battery of 25 tests, producing 15, 10, and 5 abnormal scores at 1, 1.5, and 2 standard deviations below the norm-referenced mean, respectively, and an overall test battery mean (OTBM) of T ≤ 38 accurately identifies performance invalidity. However, generalizability of these findings to other samples and test batteries remains unclear. This study evaluated the use of abnormal scores and the OTBM as performance validity measures in a different sample that was administered a 25-test battery that minimally overlapped with Davis et al.'s test battery. Archival analysis of 48 examinees with mild traumatic brain injury seen for medico-legal purposes was conducted. Producing 18 or more, 7 or more, and 5 or more abnormal scores at 1, 1.5, and 2 standard deviations below the norm-referenced mean, respectively, and an OTBM of T ≤ 40 most accurately classified examinees; however, using Davis et al.'s proposed cutoffs in the current sample maintained specificity at or near acceptable levels. Due to convergence across studies, producing ≥5 abnormal scores at 2 standard deviations below the norm-referenced mean is the most appropriate cutoff for clinical implementation; however, for batteries consisting of a different quantity of tests than 25, an OTBM of T ≤ 38 is more appropriate. PMID:25785544

  4. Passive scalars in turbulent channel flow at high Reynolds number

    NASA Astrophysics Data System (ADS)

    Pirozzoli, Sergio; Bernardini, Matteo; Orlandi, Paolo

    2015-11-01

    We study passive scalars in turbulent plane channels at computationally high Reynolds number, which allows to observe previously unnoticed effects. The mean scalar profiles are found to obey a generalized logarithmic law which includes a linear correction term in the whole lower half-channel, and they follow a universal parabolic defect profile in the core region. This is consistent with recent findings regarding the mean velocity profiles in channel flow. The scalar variances also exhibit a near universal parabolic distribution in the core flow, and hints of a sizeable log layer, unlike the velocity variances. The energy spectra highlight the formation of large scalar-bearing eddies spanning each half-channel, which are caused by production excess over dissipation, and which are clearly visible in the flow visualizations. Close correspondence of the velocity and scalar eddies is observed, the main difference being that the latter have more convoluted interfaces, which translates into higher scalar dissipation. Another notable Reynolds number effect is the decreased correlation of the scalar field with the vertical velocity field, which is traced to the reduced effectiveness of ejection events. We acknowledge that the results reported in this paper have been achieved using the PRACE Research Infrastructure resource FERMI based at CINECA, Casalecchio di Reno, Italy.

  5. High Reynolds number decay of turbulent Taylor-Couette flow

    NASA Astrophysics Data System (ADS)

    Verschoof, Ruben A.; Huisman, Sander G.; van der Veen, Roeland C. A.; Sun, Chao; Lohse, Detlef

    2015-11-01

    We study the decay of high-Reynolds number turbulence in a Taylor-Couette facility for pure inner cylinder rotation. The rotation of the inner cylinder (Rei = 2 ×106) is suddenly decelerated as fast as possible, thus removing the energy input within seconds. Local velocity measurements show that the decay in this wall-bounded inhomogeneous flow is faster than observed for homogeneous isotropic turbulent flows, due to the strong viscous drag applied by the inner and outer cylinder surfaces. We found that the decay over time can be described with the differential equation Re . (t) =cf (Re)Re2 , where the effects of the walls are included through the friction coefficient. A self-similar behavior of the azimuthal velocity is found: its normalized velocity profile as a function of the radius collapses over time during the decay process.

  6. Mixing of two miscible fluids at high Schmidt number

    NASA Astrophysics Data System (ADS)

    Simmons, Mark; Alberini, Federico; Pain, Christopher; Matar, Omar

    2013-11-01

    The blending of two miscible liquids at high Schmidt number is an increasingly common industrial problem: as processes push towards shorter timescales yet the rheology of the fluids becomes increasingly complex. This leads to phenomena which resemble a quasi two-phase system with zero interfacial tension. In this study, we compare experimental results with computational fluid dynamics simulations using unstructured-mesh adaptivity for the flow of two Newtonian, or two power-law fluids through a complex geometry representative of a Kenics type static mixer used in industry. The geometry induces a stretching and folding of the fluid elements which causes exponential growth of the interface length down the geometry. The interfacial topology obtained from the simulations is compared with experiments carried out using Planar Laser Induced Fluorescence (PLIF), which enables the spatial distribution of each phase, and the interfaces between them, to be determined at the outlet of the geometry. EPSRC Programme Grant EP/K003976/1.

  7. A High Altitude-Low Reynolds Number Aerodynamic Flight Experiment

    NASA Technical Reports Server (NTRS)

    Greer, Don; Krake, Keith; Hamory, Phil; Drela, Mark; Lee, Seunghee (Technical Monitor)

    1999-01-01

    A sailplane is currently being developed at NASA's Dryden Flight Research Center to support a high altitude flight experiment. The purpose of the experiment is to measure the performance characteristics of an airfoil at altitudes between 100,000 and 70,000 feet at Mach numbers between 0.65 and 0.5. The airfoil lift and drag are measured from pilot and static pressures. The location of the separation bubble and vortex shedding are measured from a hot film strip. The details of the flight experiment are presented. A comparison of several estimates of the airfoil performance is also presented. The airfoil, APEX-16, was designed by Drela (MIT) with his MSES code. A two dimensional Navier-Stokes analysis has been performed by Tatineni and Zhong (UCLA) and another at the Dryden Flight Research Center. The role these analysis served to define the experiment is discussed.

  8. Selective decay hypothesis at high mechanical and magnetic Reynolds numbers

    NASA Astrophysics Data System (ADS)

    Matthaeus, W. H.; Montgomery, D.

    1980-12-01

    Implications of certain applications of turbulence theory to two-dimensional turbulence and magnetohydrodynamic flow are discussed. It is shown that the use of the Navier-Stokes equation (NSE) for measurements of turbulent fluctuations has been effective only for three-dimensional flows. For two-dimensional flows, used for the study of large-scale motions in the atmosphere or ocean, enstrophy is cascaded to high wave numbers and dissipated at a finite rate even at infinite Re. MHD flows are numerically calculated for the two-dimensional case and analytically for the three-dimensional case, for which discrepancies in the relative rates of energy and cross helicity decay lead to a recommendation that numerical calculations for the three-dimensional case be carried out to determine the precise decayed states.

  9. Experimental investigations of He II flows at high Reynolds number

    NASA Technical Reports Server (NTRS)

    Van Sciver, Steve W.

    1991-01-01

    Fluid dynamics studies of He II at high Reynolds number (Re(d) greater than 10 exp 6) reveal characteristics which are best interpreted in terms of classical scaling relationships. In particular, the smooth tube friction factor is seen to correlate with the Von Karman-Nikuradse formulation. Also, the performance of a centrifugal pump is unchanged whether being used with He I or He II. These effects are expected to result provided the He II possesses a viscous sublayer and that the drag is determined by laminar flow within this layer. On the other hand, heat transfer in He II is substantially different from that of He I because of the unique internal convection mechanism present in this quantum fluid. These experiments are performed in the University of Wisconsin liquid helium flow facility which has unique capabilities of He II temperature, pressure and flow.

  10. Turbomachinery for Low-to-High Mach Number Flight

    NASA Technical Reports Server (NTRS)

    Tan, Choon S.; Shah, Parthiv N.

    2004-01-01

    The thrust capability of turbojet cycles is reduced at high flight Mach number (3+) by the increase in inlet stagnation temperature. The 'hot section' temperature limit imposed by materials technology sets the maximum heat addition and, hence, sets the maximum flight Mach number of the operating envelope. Compressor pre-cooling, either via a heat exchanger or mass-injection, has been suggested as a means to reduce compressor inlet temperature and increase mass flow capability, thereby increasing thrust. To date, however, no research has looked at compressor cooling (i.e., using a compressor both to perform work on the gas path air and extract heat from it simultaneously). We wish to assess the feasibility of this novel concept for use in low-to-high Mach number flight. The results to-date show that an axial compressor with cooling: (1) relieves choking in rear stages (hence opening up operability), (2) yields higher-pressure ratio and (3) yields higher efficiency for a given corrected speed and mass flow. The performance benefit is driven: (i) at the blade passage level, by a decrease in the total pressure reduction coefficient and an increase in the flow turning; and (ii) by the reduction in temperature that results in less work required for a given pressure ratio. The latter is a thermodynamic effect. As an example, calculations were performed for an eight-stage compressor with an adiabatic design pressure ratio of 5. By defining non-dimensional cooling as the percentage of compressor inlet stagnation enthalpy removed by a heat sink, the model shows that a non-dimensional cooling of percent in each blade row of the first two stages can increase the compressor pressure ratio by as much as 10-20 percent. Maximum corrected mass flow at a given corrected speed may increase by as much as 5 percent. In addition, efficiency may increase by as much as 5 points. A framework for characterizing and generating the performance map for a cooled compressor has been developed

  11. High Doses of Bone Morphogenetic Protein 2 Induce Structurally Abnormal Bone and Inflammation In Vivo

    PubMed Central

    Zara, Janette N.; Siu, Ronald K.; Zhang, Xinli; Shen, Jia; Ngo, Richard; Lee, Min; Li, Weiming; Chiang, Michael; Chung, Jonguk; Kwak, Jinny; Wu, Benjamin M.; Ting, Kang

    2011-01-01

    The major Food and Drug Association–approved osteoinductive factors in wide clinical use are bone morphogenetic proteins (BMPs). Although BMPs can promote robust bone formation, they also induce adverse clinical effects, including cyst-like bone formation and significant soft tissue swelling. In this study, we evaluated multiple BMP2 doses in a rat femoral segmental defect model and in a minimally traumatic rat femoral onlay model to determine its dose-dependent effects. Results of our femoral segmental defect model established a low BMP2 concentration range (5 and 10 μg/mL, total dose 0.375 and 0.75 μg in 75 μg total volume) unable to induce defect fusion, a mid-range BMP2 concentration range able to fuse the defect without adverse effects (30 μg/mL, total dose 2.25 μg in 75 μg total volume), and a high BMP2 concentration range (150, 300, and 600 μg/mL, total dose 11.25, 22.5, and 45 μg in 75 μg total volume) able to fuse the defect, but with formation of cyst-like bony shells filled with histologically confirmed adipose tissue. In addition, compared to control, 4 mg/mL BMP2 also induced significant tissue inflammatory infiltrates and exudates in the femoral onlay model that was accompanied by increased numbers of osteoclast-like cells at 3, 7, and 14 days. Overall, we consistently reproduced BMP2 side effects of cyst-like bone and soft tissue swelling using high BMP2 concentration approaching the typical human 1500 μg/mL. PMID:21247344

  12. High doses of bone morphogenetic protein 2 induce structurally abnormal bone and inflammation in vivo.

    PubMed

    Zara, Janette N; Siu, Ronald K; Zhang, Xinli; Shen, Jia; Ngo, Richard; Lee, Min; Li, Weiming; Chiang, Michael; Chung, Jonguk; Kwak, Jinny; Wu, Benjamin M; Ting, Kang; Soo, Chia

    2011-05-01

    The major Food and Drug Association-approved osteoinductive factors in wide clinical use are bone morphogenetic proteins (BMPs). Although BMPs can promote robust bone formation, they also induce adverse clinical effects, including cyst-like bone formation and significant soft tissue swelling. In this study, we evaluated multiple BMP2 doses in a rat femoral segmental defect model and in a minimally traumatic rat femoral onlay model to determine its dose-dependent effects. Results of our femoral segmental defect model established a low BMP2 concentration range (5 and 10 μg/mL, total dose 0.375 and 0.75 μg in 75 μg total volume) unable to induce defect fusion, a mid-range BMP2 concentration range able to fuse the defect without adverse effects (30 μg/mL, total dose 2.25 μg in 75 μg total volume), and a high BMP2 concentration range (150, 300, and 600 μg/mL, total dose 11.25, 22.5, and 45 μg in 75 μg total volume) able to fuse the defect, but with formation of cyst-like bony shells filled with histologically confirmed adipose tissue. In addition, compared to control, 4 mg/mL BMP2 also induced significant tissue inflammatory infiltrates and exudates in the femoral onlay model that was accompanied by increased numbers of osteoclast-like cells at 3, 7, and 14 days. Overall, we consistently reproduced BMP2 side effects of cyst-like bone and soft tissue swelling using high BMP2 concentration approaching the typical human 1500 μg/mL. PMID:21247344

  13. A tyrosinase with an abnormally high tyrosine hydroxylase/dopa oxidase ratio.

    PubMed

    Hernández-Romero, Diana; Sanchez-Amat, Antonio; Solano, Francisco

    2006-01-01

    The sequencing of the genome of Ralstonia solanacearum[Salanoubat M, Genin S, Artiguenave F, et al. (2002) Nature 415, 497-502] revealed several genes that putatively code for polyphenol oxidases (PPOs). This soil-borne pathogenic bacterium withers a wide range of plants. We detected the expression of two PPO genes (accession numbers NP_518458 and NP_519622) with high similarity to tyrosinases, both containing the six conserved histidines required to bind the pair of type-3 copper ions at the active site. Generation of null mutants in those genes by homologous recombination mutagenesis and protein purification allowed us to correlate each gene with its enzymatic activity. In contrast with all tyrosinases so far studied, the enzyme NP_518458 shows higher monophenolase than o-diphenolase activity and its initial activity does not depend on the presence of l-dopa cofactor. On the other hand, protein NP_519622 is an enzyme with a clear preference to oxidize o-diphenols and only residual monophenolase activity, behaving as a catechol oxidase. These catalytic characteristics are discussed in relation to two other characteristics apart from the six conserved histidines. One is the putative presence of a seventh histidine which interacts with the carboxy group on the substrate and controls the preference for carboxylated and decarboxylated substrates. The second is the size of the residue isosteric with the aromatic F261 reported in sweet potato catechol oxidase which acts as a gate to control accessibility to CuA at the active site. PMID:16403014

  14. Abnormally Low or High Ankle-Brachial Index Is Associated with Proliferative Diabetic Retinopathy in Type 2 Diabetic Mellitus Patients

    PubMed Central

    Chen, Szu-Chia; Hsiao, Pi-Jung; Huang, Jiun-Chi; Lin, Kun-Der; Hsu, Wei-Hao; Lee, Yu-Li; Lee, Mei-Yueh; Chang, Jer-Ming; Shin, Shyi–Jang

    2015-01-01

    Although some studies have reported that low ankle-brachial index (ABI) is associated with diabetic retinopathy (DR) in diabetic patients, it remains controversial as to which stage of DR. The aim of this study is to assess whether peripheral artery disease (PAD), indicated by abnormally low or high ABI, is associated with different stages of DR in patients with type 2 diabetes mellitus (DM), and further evaluate the risk factors. A total of 2001 (858 men and 1143 women) patients with type 2 DM who underwent ABI measurement in an outpatient clinic were enrolled. PAD was defined as ABI < 0.9 or ≧ 1.3 in either leg. DR was classified as non-DR, nonproliferative DR and proliferative DR stages. The clinical data were analyzed and the risk factors for abnormal ABI were determined by multivariate logistic regression analysis. The prevalence of ABI < 0.9 or ≧ 1.3 was 3.0%. Multivariate forward logistic regression analysis identified proliferative DR (vs. non-DR) was associated with abnormal ABI (odds ratio, 1.718; 95% confidence interval, 1.152 to 2.562; p = 0.008), but nonproliferative DR was not. Furthermore, the presence of coronary artery disease, cerebrovascular disease, declining renal function and patients without diuretics use were associated with abnormal ABI in patients with proliferative DR. Our study in patients of type 2 DM demonstrated that PAD was associated with proliferative DR. We emphasize the recommendation of performing the ABI test in this population at risk. PMID:26230390

  15. Substrate degradation in high-Rayleigh-number reactive convection

    NASA Astrophysics Data System (ADS)

    Ward, T. J.; Jensen, O. E.; Power, H.; Riley, D. S.

    2015-11-01

    We study buoyancy-induced convection of a solute in an ideal two-dimensional fluid-saturated porous medium, where the solute undergoes a second-order reaction with a chemical substrate that is fixed in the underlying matrix. Numerical simulations at high Rayleigh number show how a flow is established in which a thin dynamic boundary layer beneath the solute source feeds slender vertical plumes beneath. We examine how the substrate is reactively degraded, at a rate enhanced by convective mixing. For the case when the substrate is abundant, we derive a reduced-order model describing the slow degradation of the substrate, which is formulated as a novel one-dimensional free-boundary problem. Numerical simulations and the reduced model reveal how, when the reaction is rapid compared to the convective time scale, the plumes propagate deep into the flow domain with reaction confined to a narrow region at their base. In contrast, slow reaction allows plumes to fill the domain before degradation of the substrate proceeds homogeneously. An alternative model with a thin reaction front captures the rapid degradation of the substrate when the solute concentration is relatively high.

  16. Craniofacial Abnormalities

    MedlinePlus

    ... of the skull and face. Craniofacial abnormalities are birth defects of the face or head. Some, like cleft ... palate, are among the most common of all birth defects. Others are very rare. Most of them affect ...

  17. Walking abnormalities

    MedlinePlus

    ... include: Arthritis of the leg or foot joints Conversion disorder (a psychological disorder) Foot problems (such as a ... injuries. For an abnormal gait that occurs with conversion disorder, counseling and support from family members are strongly ...

  18. Chromosome Abnormalities

    MedlinePlus

    ... decade, newer techniques have been developed that allow scientists and doctors to screen for chromosomal abnormalities without using a microscope. These newer methods compare the patient's DNA to a normal DNA ...

  19. Nail abnormalities

    MedlinePlus

    Nail abnormalities are problems with the color, shape, texture, or thickness of the fingernails or toenails. ... Fungus or yeast cause changes in the color, texture, and shape of the nails. Bacterial infection may ...

  20. Dynamics of Active Separation Control at High Reynolds Numbers

    NASA Technical Reports Server (NTRS)

    Pack, LaTunia G.; Seifert, Avi

    2000-01-01

    A series of active flow control experiments were recently conducted at high Reynolds numbers on a generic separated configuration. The model simulates the upper surface of a 20% thick Glauert-Goldschmied type airfoil at zero angle of attack. The flow is fully turbulent since the tunnel sidewall boundary layer flows over the model. The main motivation for the experiments is to generate a comprehensive data base for validation of unsteady numerical simulation as a first step in the development of a CFD design tool, without which it would not be possible to effectively utilize the great potential of unsteady flow control. This paper focuses on the dynamics of several key features of the baseline as well as the controlled flow. It was found that the thickness of the upstream boundary layer has a negligible effect on the flow dynamics. It is speculated that separation is caused mainly by the highly convex surface while viscous effects are less important. The two-dimensional separated flow contains unsteady waves centered on a reduced frequency of 0.8, while in the three dimensional separated flow, frequencies around a reduced frequency of 0.3 and 1 are active. Several scenarios of resonant wave interaction take place at the separated shear-layer and in the pressure recovery region. The unstable reduced frequency bands for periodic excitation are centered on 1.5 and 5, but these reduced frequencies are based on the length of the baseline bubble that shortens due to the excitation. The conventional swept wing-scaling works well for the coherent wave features. Reproduction of these dynamic effects by a numerical simulation would provide benchmark validation.

  1. Efficient simulation of detached flows at high Reynolds number

    NASA Astrophysics Data System (ADS)

    Vega, Jose M.; Asensio, Victor; Herrero, Raul; Varas, Fernando

    2014-11-01

    A method is presented for the computationally efficient simulation of quasi-periodic detached flows in multi-parameter problems at very large Reynolds numbers, keeping in mind a variety of applications, including helicopter flight simulators, control and certification of unmanned aerial vehicles, control of wind turbines, conceptual design in aeronautics, and civil aerodynamics. In many of these applications, the large scale flows (ignoring the smaller turbulent scales) are at most quasi-periodic, namely the Fourier transform exhibits a finite set of concentrated peaks resulting from the nonlinear passive interaction of periodic wakes. The method consists in an offline preprocess and the online operation. In the preprocess, a standard CFD solver (such as URANS) is used in combination with several ingredients such as an iterative combination proper orthogonal decomposition and fast Fourier transform. The online operation is made with a combination of high order singular value decomposition and interpolation. The performance of the method is tested considering the ow over a fairly complex urban topography, for various free stream intensities and orientations, seeking real time online simulations.

  2. Interaction of upstream flow distortions with high Mach number cascades

    NASA Technical Reports Server (NTRS)

    Englert, G. W.

    1981-01-01

    Features of the interaction of flow distortions, such as gusts and wakes with blade rows of advance type fans and compressors having high tip Mach numbers are modeled. A typical disturbance was assumed to have harmonic time dependence and was described, at a far upstream location, in three orthogonal spatial coordinates by a double Fourier series. It was convected at supersonic relative to a linear cascade described as an unrolled annulus. Conditions were selected so that the component of this velocity parallel to the axis of the turbomachine was subsonic, permitting interaction between blades through the upstream as well as downstream flow media. A strong, nearly normal shock was considered in the blade passages which was allowed curvature and displacement. The flows before and after the shock were linearized relative to uniform mean velocities in their respective regions. Solution of the descriptive equations was by adaption of the Wiener-Hopf technique, enabling a determination of distortion patterns through and downstream of the cascade as well as pressure distributions on the blade and surfaces. Details of interaction of the disturbance with the in-passage shock were discussed. Infuences of amplitude, wave length, and phase of the disturbance on lifts and moments of cascade configurations are presented. Numerical results are clarified by reference to an especially orderly pattern of upstream vertical motion in relation to the cascade parameters.

  3. Toward Immersed Boundary Simulation of High Reynolds Number Flows

    NASA Technical Reports Server (NTRS)

    Kalitzin, Georgi; Iaccarino, Gianluca

    2003-01-01

    of high Reynolds number wall bounded flows is particularly challenging as it requires the consideration of thin turbulent boundary layers, i.e. near wall regions with large gradients of the flow field variables. For such flows, the representation of the wall boundary has a large impact on the accuracy of the computation. It is also critical for the robustness and convergence of the flow solver.

  4. Mapping of Genetic Abnormalities of Primary Tumours from Metastatic CRC by High-Resolution SNP Arrays

    PubMed Central

    Sayagués, José María; Fontanillo, Celia; Abad, María del Mar; González-González, María; Sarasquete, María Eugenia; del Carmen Chillon, Maria; Garcia, Eva; Bengoechea, Oscar; Fonseca, Emilio; Gonzalez-Diaz, Marcos; De Las Rivas, Javier

    2010-01-01

    Background For years, the genetics of metastatic colorectal cancer (CRC) have been studied using a variety of techniques. However, most of the approaches employed so far have a relatively limited resolution which hampers detailed characterization of the common recurrent chromosomal breakpoints as well as the identification of small regions carrying genetic changes and the genes involved in them. Methodology/Principal Findings Here we applied 500K SNP arrays to map the most common chromosomal lesions present at diagnosis in a series of 23 primary tumours from sporadic CRC patients who had developed liver metastasis. Overall our results confirm that the genetic profile of metastatic CRC is defined by imbalanced gains of chromosomes 7, 8q, 11q, 13q, 20q and X together with losses of the 1p, 8p, 17p and 18q chromosome regions. In addition, SNP-array studies allowed the identification of small (<1.3 Mb) and extensive/large (>1.5 Mb) altered DNA sequences, many of which contain cancer genes known to be involved in CRC and the metastatic process. Detailed characterization of the breakpoint regions for the altered chromosomes showed four recurrent breakpoints at chromosomes 1p12, 8p12, 17p11.2 and 20p12.1; interestingly, the most frequently observed recurrent chromosomal breakpoint was localized at 17p11.2 and systematically targeted the FAM27L gene, whose role in CRC deserves further investigations. Conclusions/Significance In summary, in the present study we provide a detailed map of the genetic abnormalities of primary tumours from metastatic CRC patients, which confirm and extend on previous observations as regards the identification of genes potentially involved in development of CRC and the metastatic process. PMID:21060790

  5. High quality topic extraction from business news explains abnormal financial market volatility.

    PubMed

    Hisano, Ryohei; Sornette, Didier; Mizuno, Takayuki; Ohnishi, Takaaki; Watanabe, Tsutomu

    2013-01-01

    Understanding the mutual relationships between information flows and social activity in society today is one of the cornerstones of the social sciences. In financial economics, the key issue in this regard is understanding and quantifying how news of all possible types (geopolitical, environmental, social, financial, economic, etc.) affects trading and the pricing of firms in organized stock markets. In this article, we seek to address this issue by performing an analysis of more than 24 million news records provided by Thompson Reuters and of their relationship with trading activity for 206 major stocks in the S&P US stock index. We show that the whole landscape of news that affects stock price movements can be automatically summarized via simple regularized regressions between trading activity and news information pieces decomposed, with the help of simple topic modeling techniques, into their "thematic" features. Using these methods, we are able to estimate and quantify the impacts of news on trading. We introduce network-based visualization techniques to represent the whole landscape of news information associated with a basket of stocks. The examination of the words that are representative of the topic distributions confirms that our method is able to extract the significant pieces of information influencing the stock market. Our results show that one of the most puzzling stylized facts in financial economies, namely that at certain times trading volumes appear to be "abnormally large," can be partially explained by the flow of news. In this sense, our results prove that there is no "excess trading," when restricting to times when news is genuinely novel and provides relevant financial information. PMID:23762258

  6. High Quality Topic Extraction from Business News Explains Abnormal Financial Market Volatility

    PubMed Central

    Hisano, Ryohei; Sornette, Didier; Mizuno, Takayuki; Ohnishi, Takaaki; Watanabe, Tsutomu

    2013-01-01

    Understanding the mutual relationships between information flows and social activity in society today is one of the cornerstones of the social sciences. In financial economics, the key issue in this regard is understanding and quantifying how news of all possible types (geopolitical, environmental, social, financial, economic, etc.) affects trading and the pricing of firms in organized stock markets. In this article, we seek to address this issue by performing an analysis of more than 24 million news records provided by Thompson Reuters and of their relationship with trading activity for 206 major stocks in the S&P US stock index. We show that the whole landscape of news that affects stock price movements can be automatically summarized via simple regularized regressions between trading activity and news information pieces decomposed, with the help of simple topic modeling techniques, into their “thematic” features. Using these methods, we are able to estimate and quantify the impacts of news on trading. We introduce network-based visualization techniques to represent the whole landscape of news information associated with a basket of stocks. The examination of the words that are representative of the topic distributions confirms that our method is able to extract the significant pieces of information influencing the stock market. Our results show that one of the most puzzling stylized facts in financial economies, namely that at certain times trading volumes appear to be “abnormally large,” can be partially explained by the flow of news. In this sense, our results prove that there is no “excess trading,” when restricting to times when news is genuinely novel and provides relevant financial information. PMID:23762258

  7. Helicon waves in uniform plasmas. II. High m numbers

    NASA Astrophysics Data System (ADS)

    Stenzel, R. L.; Urrutia, J. M.

    2015-09-01

    Helicons are whistler modes with azimuthal wave numbers. They have been studied in solids and plasmas where boundaries play a role. The present work shows that very similar modes exist in unbounded gaseous plasmas. Instead of boundaries, the antenna properties determine the topology of the wave packets. The simplest antenna is a magnetic loop which excites m = 0 or m = 1 helicons depending on whether the dipole moment is aligned parallel or perpendicular to the ambient background magnetic field B0. While these low order helicons have been described by J. M. Urrutia and R. L. Stenzel ["Helicon modes in uniform plasmas. I. Low m modes," Phys. Plasmas 22, 092111 (2015)], the present work focuses on high order modes up to m = 8. These are excited by antenna arrays forming magnetic multipoles. Their wave magnetic field has been measured in space and time in a large and uniform laboratory plasma free of boundary effects. The observed wave topology exhibits m pairs of unique field line spirals which may have inspired the name "helicon" to this mode. All field lines converge into these nested spirals which propagate like corkscrews along B0. The field lines near the axis of helicons are perpendicular to B0 and circularly polarized as in parallel whistlers. Helical antennas couple to these transverse fields but not to the spiral fields of helicons. Using a circular antenna array of phased m = 0 loops, right or left rotating or non-rotating multipole antenna fields are generated. They excite m < 0 and m > 0 modes, showing that the plasma supports both modes equally well. The poor excitation of m < 0 modes is a characteristic of loops with dipole moment across B0. The radiation efficiency of multipole antennas has been found to decrease with m.

  8. Helicon waves in uniform plasmas. II. High m numbers

    SciTech Connect

    Stenzel, R. L.; Urrutia, J. M.

    2015-09-15

    Helicons are whistler modes with azimuthal wave numbers. They have been studied in solids and plasmas where boundaries play a role. The present work shows that very similar modes exist in unbounded gaseous plasmas. Instead of boundaries, the antenna properties determine the topology of the wave packets. The simplest antenna is a magnetic loop which excites m = 0 or m = 1 helicons depending on whether the dipole moment is aligned parallel or perpendicular to the ambient background magnetic field B{sub 0}. While these low order helicons have been described by J. M. Urrutia and R. L. Stenzel [“Helicon modes in uniform plasmas. I. Low m modes,” Phys. Plasmas 22, 092111 (2015)], the present work focuses on high order modes up to m = 8. These are excited by antenna arrays forming magnetic multipoles. Their wave magnetic field has been measured in space and time in a large and uniform laboratory plasma free of boundary effects. The observed wave topology exhibits m pairs of unique field line spirals which may have inspired the name “helicon” to this mode. All field lines converge into these nested spirals which propagate like corkscrews along B{sub 0}. The field lines near the axis of helicons are perpendicular to B{sub 0} and circularly polarized as in parallel whistlers. Helical antennas couple to these transverse fields but not to the spiral fields of helicons. Using a circular antenna array of phased m = 0 loops, right or left rotating or non-rotating multipole antenna fields are generated. They excite m < 0 and m > 0 modes, showing that the plasma supports both modes equally well. The poor excitation of m < 0 modes is a characteristic of loops with dipole moment across B{sub 0}. The radiation efficiency of multipole antennas has been found to decrease with m.

  9. Maternal high-fat hypercaloric diet during pregnancy results in persistent metabolic and respiratory abnormalities in offspring

    PubMed Central

    Griffiths, Pamela S.; Walton, Cheryl; Samsell, Lennie; Perez, Miriam K.; Piedimonte, Giovanni

    2016-01-01

    Background: We have shown in a previous population-based study significant correlation between childhood asthma and early abnormalities of lipid and glucose metabolism. This study's specific aim was to determine whether maternal nutrition in pregnancy affects postnatal metabolic and respiratory outcomes in the offspring. Methods: On gestation day 1, dams were switched from standard chow to either high-fat hypercaloric diet or control diet. Terminal experiments were performed on newborn and weanling offspring of dams fed the study diet during gestation and lactation, and on adult offspring maintained on the same diet as their mother. Results: Pups born from high-fat hypercaloric diet (HFD) dams developed metabolic abnormalities persistent throughout development. Cytokine expression analysis of lung tissues from newborns born to HFD dams revealed a strong proinflammatory pattern. Gene expression of neurotrophic factors and receptors was upregulated in lungs of weanlings born to HFD dams, and this was associated to higher respiratory system resistance and lower compliance at baseline, as well as hyperreactivity to aerosolized methacholine. Furthermore, HFD dams delivered pups prone to develop more severe disease after respiratory syncytial virus (RSV) infection. Conclusion: Maternal nutrition in pregnancy is a critical determinant of airway inflammation and hyperreactivity in offspring and also increases risk for bronchiolitis independent from prepregnancy nutrition. PMID:26539661

  10. The cryogenic wind tunnel concept for high Reynolds number testing

    NASA Technical Reports Server (NTRS)

    Kilgore, R. A.; Goodyer, M. J.; Adcock, J. B.; Davenport, E. E.

    1974-01-01

    Theoretical considerations indicate that cooling the wind-tunnel test gas to cryogenic temperatures will provide a large increase in Reynolds number with no increase in dynamic pressure while reducing the tunnel drive-power requirements. Studies were made to determine the expected variations of Reynolds number and other parameters over wide ranges of Mach number, pressure, and temperature, with due regard to avoiding liquefaction. Practical operational procedures were developed in a low-speed cryogenic tunnel. Aerodynamic experiments in the facility demonstrated the theoretically predicted variations in Reynolds number and drive power. The continuous-flow-fan-driven tunnel is shown to be particularly well suited to take full advantage of operating at cryogenic temperatures.

  11. EUROarray human papillomavirus (HPV) assay is highly concordant with other commercial assays for detection of high-risk HPV genotypes in women with high grade cervical abnormalities.

    PubMed

    Cornall, A M; Poljak, M; Garland, S M; Phillips, S; Machalek, D A; Tan, J H; Quinn, M A; Tabrizi, S N

    2016-06-01

    The purpose of this study was to evaluate the performance of the EUROIMMUN EUROArray HPV genotyping assay against the Roche Cobas 4800, Roche HPV Amplicor, Roche Linear Array and Qiagen Hybrid Capture 2 assays in the detection of high-risk HPV (HR-HPV) from liquid based cervical cytology samples collected from women undergoing follow-up for abnormal cervical cytology results. Cervical specimens from 404 women undergoing management of high-grade cytological abnormality were evaluated by EUROarray HPV for detection of HR-HPV genotypes and prediction of histologically-confirmed cervical intraepithelial neoplasia grade 2 or higher (≥CIN2). The results were compared to Hybrid Capture 2, Cobas 4800 HPV, Amplicor and Linear Array HPV. Positivity for 14 HR-HPV types was 80.0 % for EUROarray (95 % CI; 75.7-83.8 %). Agreement (κ, 95 % CI) between the EUROarray and other HPV tests for detection of HR-HPV was good to very good [Hybrid Capture κ = 0.62 (0.54-0.71); Cobas κ = 0.81 (0.74-0.88); Amplicor κ = 0.68 (0.60-0.77); Linear Array κ = 0.77 (0.70-0.85)]. For detection of HR-HPV, agreement with EUROarray was 87.90 % (Hybrid Capture), 93.58 % (Cobas), 92.84 % (Amplicor) and 92.59 % (Linear Array). Detection of HR-HPV was not significantly different between EUROarray and any other test (p < 0.001). EUROarray was concordant with other assays evaluated for detection of high-risk HPV and showed sensitivity and specificity for detection of ≥ CIN2 of 86 % and 71 %, respectively. PMID:27048314

  12. 'Abnormal' angle response curves of TW/Rs for near zero tilt and high tilt channeling implants

    SciTech Connect

    Guo Baonian; Gossmann, Hans-Joachim; Toh, Terry; Colombeau, Benjamin; Todorov, Stan; Sinclair, Frank; Shim, Kyu-Ha; Henry, Todd

    2012-11-06

    Angle control has been widely accepted as the key requirement for ion implantation in semiconductor device processing. From an ion implanter point of view, the incident ion direction should be measured and corrected by suitable techniques, such as XP-VPS for the VIISta implanter platform, to ensure precision ion placement in device structures. So called V-curves have been adopted to generate the wafer-based calibration using channeling effects as the Si lattice steer ions into a channeling direction. Thermal Wave (TW) or sheet resistance (Rs) can be used to determine the minimum of the angle response curve. Normally it is expected that the TW and Rs have their respective minima at identical angles. However, the TW and Rs response to the angle variations does depend on factors such as implant species, dose, and wafer temperature. Implant damage accumulation effects have to be considered for data interpretation especially for some 'abnormal' V-curve data. In this paper we will discuss some observed 'abnormal' angle responses, such as a) TW/Rs reverse trend for Arsenic beam, 2) 'W' shape of Rs Boron, and 3) apparent TW/Rs minimum difference for high tilt characterization, along with experimental data and TCAD simulations.

  13. High Reynolds number effects on a localized stratified turbulent flow

    NASA Astrophysics Data System (ADS)

    Zhou, Qi; Diamessis, Peter

    2015-11-01

    We report large-eddy simulations (LES) of the turbulent flow behind a sphere of diameter D translating at speed U in a linearly stratified Boussinesq fluid with buoyancy frequency N. These simulations are performed using a spectral-multidomain-penalty incompressible Navier-Stokes solver, at Reynolds numbers Re ≡ UD / ν ∈ { 5 ×103 , 105 , 4 ×105 } and Froude numbers Fr ≡ 2 U / (ND) ∈ { 4 , 16 , 64 } . An increasingly richer turbulent fine-structure is observed within the larger-scale quasi-horizontal vortices at later times. Turbulent transport of momentum is examined during the non-equilibrium (NEQ) regime of the turbulent life cycle, with an emphasis on the vertical transport that occurs after the establishment of local buoyancy control. The turbulent viscosities in both horizontal and vertical directions are estimated through the LES data; possible parameterization of the vertical turbulent viscosity with the buoyancy Reynolds number Reb = ɛ / (νN2) (or its easy-to-obtain surrogates) is discussed. The dynamical role of the buoyancy Reynolds number in choosing the vertical turbulence length scales is also investigated. ONR grant N00014-13-1-0665 (managed by Dr. R. Joslin); HPCMP Frontier Project FP-CFD-FY14-007 (P.I.: Dr. S. de Bruyn Kops).

  14. Prediction of Very High Reynolds Number Compressible Skin Friction

    NASA Technical Reports Server (NTRS)

    Carlson, John R.

    1998-01-01

    Flat plate skin friction calculations over a range of Mach numbers from 0.4 to 3.5 at Reynolds numbers from 16 million to 492 million using a Navier Stokes method with advanced turbulence modeling are compared with incompressible skin friction coefficient correlations. The semi-empirical correlation theories of van Driest; Cope; Winkler and Cha; and Sommer and Short T' are used to transform the predicted skin friction coefficients of solutions using two algebraic Reynolds stress turbulence models in the Navier-Stokes method PAB3D. In general, the predicted skin friction coefficients scaled well with each reference temperature theory though, overall the theory by Sommer and Short appeared to best collapse the predicted coefficients. At the lower Reynolds number 3 to 30 million, both the Girimaji and Shih, Zhu and Lumley turbulence models predicted skin-friction coefficients within 2% of the semi-empirical correlation skin friction coefficients. At the higher Reynolds numbers of 100 to 500 million, the turbulence models by Shih, Zhu and Lumley and Girimaji predicted coefficients that were 6% less and 10% greater, respectively, than the semi-empirical coefficients.

  15. Numerical simulations of thermal convection at high Prandtl numbers

    NASA Astrophysics Data System (ADS)

    Silano, Gabriella

    2008-11-01

    Direct numerical simulations of thermal convection are conducted for a cylindrical cell of aspect ratio .5ex1-.1em/ -.15em.25ex2 . The Prandtl number (Pr) varies from 10^0 to 10^4 and the Rayleigh numbers (Ra) are moderate (10^5 < Ra < 10^9). This study is motivated by the fact that the role of the Prandtl number in convective heat transport is not yet fully understood. The three-dimensional behaviors of the temperature and velocity fields, of the viscous and thermal dissipation fields, and of the diffusive and convective heat fluxes are explored. In the ranges of Pr and Ra considered, we find steady, periodic and chaotic regimes, and large-scale structures which are more complex than the single recirculation cell filling the whole volume. Multiple flow structures are found to be associated with a given set of conditions. The multiple solutions seem to be more probable at higher Pr numbers and could explain the scatter in some data trends. In collaboration with Katepalli Raju Sreenivasan, The Abdus Salam International Centre for Theoretical Physics - Trieste, and Roberto Verzicco, DIM, Universitàdegli Studi di Roma Tor Vergata - Roma.

  16. High Reynolds Number Configuration Development of a High-Lift Airfoil

    NASA Technical Reports Server (NTRS)

    Valarezo, Walter O.; Dominik, Chet J.; Mcghee, Robert J.; Goodman, Wesley L.

    1993-01-01

    An experimental program has been conducted to assess performance of a transport multielement airfoil at flight Reynolds numbers. The studies were performed at chord Reynolds numbers as high as 16 million in the NASA Langley Low Turbulence Pressure Tunnel. Sidewall boundary-layer control to enforce flow two dimensionality was provided via an endplate suction system. The basic airfoil was an 11.55 percent thick supercritical airfoil representative of the stall critical station of a new-generation transport aircraft wing. The multielement airfoil was configured as a three-element airfoil with slat and flap chord ratios of 14.48 percent and 30 percent respectively. Testing focused on the development of landing configurations with high maximum lift capability and the assessment of Reynolds and Mach number effects. Also assessed were high-lift performance effects due to devices such as drooped spoilers and trailing-edge wedges. The present experimental studies revealed significant effects on high-lift airfoil performance due to Reynolds and Mach number variations and favorable lift increments at approach angles of attack due to the use of drooped spoilers or trailing-edge wedges. However, no substantial improvements in maximum lift capability were identified. A recently developed high performance single-segment flap was also tested and results indicated considerable improvements in lift and drag performance over existing airfoils. Additionally, it was found that this new flap shape at its optimum rigging was less sensitive to Reynolds number variations than previous designs.

  17. Quantification of the DNA content of structurally abnormal X chromosomes and X chromosome aneuploidy using high resolution bivariate flow karyotyping.

    PubMed

    Trask, B; van den Engh, G; Nussbaum, R; Schwartz, C; Gray, J

    1990-01-01

    Quantification of the Hoechst and chromomycin A3 fluorescence intensities of mitotic human chromosomes isolated from karyotypically normal and abnormal cells was performed with a dual beam flow cytometer. The resultant flow karyotypes contain information about the relative DNA content and base composition of chromosomes and their relative frequencies in the mitotic cell sample. The relative copy number of X and Y chromosomes was determined for 38 normal males and females and 6 cell lines with X or Y chromosome aneuploidy. Flow karyotype diagnoses corresponded with conventional cytogenetic results in all cases. We show that chromosome DNA content can be derived from peak position in Hoechst vs. chromomycin flow karyotypes. These values are linearly related to propidium iodide staining intensity as measured with flow cytometry and to the binding of gallocyanin chrome alum to phosphate groups as measured with slide-based scanning photometry. Cell lines with deleted or dicentric X chromosomes ranging in length from 0.53 to 1.95 times normal were analyzed by using flow cytometry. The measured difference in DNA content between a normal X and each of the structurally abnormal chromosomes was linearly correlated to the difference predicted from cytogenetics and/or probe analyses. Deletions of 3-5 Mb, which were at and below the detection limits of conventional cytogenetics, could be quantified by flow karyotyping in individuals with X-linked diseases such as Duchenne muscular dystrophy, choroideremia, and ocular albinism/ichthyosis. The results show that the use of flow karyotyping to quantify the size of restricted regions of the genome can complement conventional cytogenetics and other physical mapping techniques in the study of genetic disorders. PMID:2106419

  18. Multiplier less high-speed squaring circuit for binary numbers

    NASA Astrophysics Data System (ADS)

    Sethi, Kabiraj; Panda, Rutuparna

    2015-03-01

    The squaring operation is important in many applications in signal processing, cryptography etc. In general, squaring circuits reported in the literature use fast multipliers. A novel idea of a squaring circuit without using multipliers is proposed in this paper. Ancient Indian method used for squaring decimal numbers is extended here for binary numbers. The key to our success is that no multiplier is used. Instead, one squaring circuit is used. The hardware architecture of the proposed squaring circuit is presented. The design is coded in VHDL and synthesised and simulated in Xilinx ISE Design Suite 10.1 (Xilinx Inc., San Jose, CA, USA). It is implemented in Xilinx Vertex 4vls15sf363-12 device (Xilinx Inc.). The results in terms of time delay and area is compared with both modified Booth's algorithm and squaring circuit using Vedic multipliers. Our proposed squaring circuit seems to have better performance in terms of both speed and area.

  19. The riddle of high-energy baryon number violation

    SciTech Connect

    Mattis, M.P.

    1991-09-01

    The exciting possibility that anomalous baryon and lepton number violation might be observable at the next generation of supercolliders is suggested by an instanton calculation due to Ringwald and Espinosa. In these Lectures, the current controversial status of these claims is discussed, and several new technologies designed to analyze this question are reviewed. These technologies should contribute more generally to our understanding of weakly- coupled field theories in the nonperturbative regime where both energies and multiplicities are very large. 61 refs., 35 figs.

  20. Distinct Patterns of Grey Matter Abnormality in High-Functioning Autism and Asperger's Syndrome

    ERIC Educational Resources Information Center

    McAlonan, Grainne M.; Suckling, John; Wong, Naikei; Cheung, Vinci; Lienenkaemper, Nina; Cheung, Charlton; Chua, Siew E.

    2008-01-01

    Background: Autism exists across a wide spectrum and there is considerable debate as to whether children with Asperger's syndrome, who have normal language milestones, should be considered to comprise a subgroup distinct other from high-functioning children with autism (HFA), who have a history of delayed language development. Magnetic resonance…

  1. Abnormal dosage of ultraconserved elements is highly disfavored in healthy cells but not cancer cells.

    PubMed

    McCole, Ruth B; Fonseka, Chamith Y; Koren, Amnon; Wu, C-Ting

    2014-10-01

    Ultraconserved elements (UCEs) are strongly depleted from segmental duplications and copy number variations (CNVs) in the human genome, suggesting that deletion or duplication of a UCE can be deleterious to the mammalian cell. Here we address the process by which CNVs become depleted of UCEs. We begin by showing that depletion for UCEs characterizes the most recent large-scale human CNV datasets and then find that even newly formed de novo CNVs, which have passed through meiosis at most once, are significantly depleted for UCEs. In striking contrast, CNVs arising specifically in cancer cells are, as a rule, not depleted for UCEs and can even become significantly enriched. This observation raises the possibility that CNVs that arise somatically and are relatively newly formed are less likely to have established a CNV profile that is depleted for UCEs. Alternatively, lack of depletion for UCEs from cancer CNVs may reflect the diseased state. In support of this latter explanation, somatic CNVs that are not associated with disease are depleted for UCEs. Finally, we show that it is possible to observe the CNVs of induced pluripotent stem (iPS) cells become depleted of UCEs over time, suggesting that depletion may be established through selection against UCE-disrupting CNVs without the requirement for meiotic divisions. PMID:25340765

  2. Grid-generated isotropic homogeneous turbulence at high Reynolds numbers

    NASA Technical Reports Server (NTRS)

    Rosen, G.

    1981-01-01

    Consideration is given to an empirical formula for the longitudinal correlation function for grid-generated incompressible fluid turbulence at Reynolds numbers above 12,800. The formula, which relates the longitudinal correlation function to the inverse cube of a dimensionless geometrical ratio, is shown to minimize the global correlation integrals into which the two-point velocity correlation tensor has been substituted subject to a global constraint on the Sobolev concomitent of the longitudinal correlation function. Furthermore, the energy spectrum function associated with the empirical formula is shown to satisfy a tertiary Helmholtz-type linear condition throughout the initial period of decay.

  3. Decreased numbers of chemotactic factor receptors in chronic neutropenia with defective chemotaxis: spontaneous recovery from the neutrophil abnormalities during early childhood

    SciTech Connect

    Yasui, K.; Yamazaki, M.; Miyagawa, Y.; Komiyama, A.; Akabane, T.

    1987-05-01

    Childhood chronic neutropenia with decreased numbers of chemotactic factor receptors as well as defective chemotaxis was first demonstrated in an 8-month-old girl. Chemotactic factor receptors on neutrophils were assayed using tritiated N-formyl-methionyl-leucyl-phenylalanine (/sup 3/H-FMLP). The patient's neutrophils had decreased numbers of the receptors: numbers of the receptors were 20,000 (less than 3 SD) as compared with those of control cells of 52,000 +/- 6000 (mean +/- SD) (n = 10). The neutropenia disappeared spontaneously by 28 months of age parallel with the improvement of chemotaxis and increase in numbers of chemotactic factor receptors. These results demonstrate a transient decrease of neutrophil chemotactic factor receptors as one of the pathophysiological bases of a transient defect of neutrophil chemotaxis in this disorder.

  4. Turbulent Boundary Layer in High Rayleigh Number Convection in Air

    NASA Astrophysics Data System (ADS)

    du Puits, Ronald; Li, Ling; Resagk, Christian; Thess, André; Willert, Christian

    2014-03-01

    Flow visualizations and particle image velocimetry measurements in the boundary layer of a Rayleigh-Bénard experiment are presented for the Rayleigh number Ra =1.4×1010. Our visualizations indicate that the appearance of the flow structures is similar to ordinary (isothermal) turbulent boundary layers. Our particle image velocimetry measurements show that vorticity with both positive and negative sign is generated and that the smallest flow structures are 1 order of magnitude smaller than the boundary layer thickness. Additional local measurements using laser Doppler velocimetry yield turbulence intensities up to I=0.4 as in turbulent atmospheric boundary layers. From our observations, we conclude that the convective boundary layer becomes turbulent locally and temporarily although its Reynolds number Re ≈200 is considerably smaller than the value 420 underlying existing phenomenological theories. We think that, in turbulent Rayleigh-Bénard convection, the transition of the boundary layer towards turbulence depends on subtle details of the flow field and is therefore not universal.

  5. Design of a High-Reynolds Number Recirculating Water Tunnel

    NASA Astrophysics Data System (ADS)

    Daniel, Libin; Elbing, Brian

    2014-11-01

    An experimental fluid mechanics laboratory focused on turbulent boundary layers, drag reduction techniques, multiphase flows and fluid-structure interactions has recently been established at Oklahoma State University. This laboratory has three primary components; (1) a recirculating water tunnel, (2) a multiphase pipe flow loop, and (3) a multi-scale flow visualization system. The design of the water tunnel is the focus of this talk. The criteria used for the water tunnel design was that it had to produce a momentum-thickness based Reynolds number in excess of 104, negligible flow acceleration due to boundary layer growth, maximize optical access for use of the flow visualization system, and minimize inlet flow non-uniformity. This Reynolds number was targeted to bridge the gap between typical university/commercial water tunnels (103) and the world's largest water tunnel facilities (105) . These objectives were achieved with a 152 mm (6-inch) square test section that is 1 m long and has a maximum flow speed of 10 m/s. The flow non-uniformity was mitigated with the use of a tandem honeycomb configuration, a settling chamber and an 8.5:1 contraction. The design process that produced this final design will be presented along with its current status.

  6. High-Reynolds Number Taylor-Couette Turbulence

    NASA Astrophysics Data System (ADS)

    Grossmann, Siegfried; Lohse, Detlef; Sun, Chao

    2016-01-01

    Taylor-Couette flow, the flow between two coaxial co- or counter-rotating cylinders, is one of the paradigmatic systems in the physics of fluids. The (dimensionless) control parameters are the Reynolds numbers of the inner and outer cylinders, the ratio of the cylinder radii, and the aspect ratio. One key response of the system is the torque required to retain constant angular velocities, which can be connected to the angular velocity transport through the gap. Whereas the low-Reynolds number regime was well explored in the 1980s and 1990s of the past century, in the fully turbulent regime major research activity developed only in the past decade. In this article, we review this recent progress in our understanding of fully developed Taylor-Couette turbulence from the experimental, numerical, and theoretical points of view. We focus on the parameter dependence of the global torque and on the local flow organization, including velocity profiles and boundary layers. Next, we discuss transitions between different (turbulent) flow states. We also elaborate on the relevance of this system for astrophysical disks (quasi-Keplerian flows). The review ends with a list of challenges for future research on turbulent Taylor-Couette flow.

  7. High Fat Diet Produces Brain Insulin Resistance, Synaptodendritic Abnormalities and Altered Behavior in Mice

    PubMed Central

    Arnold, Steven E.; Lucki, Irwin; Brookshire, Bethany R.; Carlson, Gregory C.; Browne, Carolyn A.; Kazi, Hala; Bang, Sookhee; Choi, Bo-Ran; Chen, Yong; McMullen, Mary F.; Kim, Sangwon F.

    2014-01-01

    Insulin resistance and other features of the metabolic syndrome are increasingly recognized for their effects on cognitive health. To ascertain mechanisms by which this occurs, we fed mice a very high fat diet (60% kcal by fat) for 17 days or a moderate high fat diet (HFD, 45% kcal by fat) for 8 weeks and examined changes in brain insulin signaling responses, hippocampal synaptodendritic protein expression, and spatial working memory. Compared to normal control diet mice, cerebral cortex tissues of HFD mice were insulin-resistant as evidenced by failed activation of Akt, S6 and GSK3β with ex-vivo insulin stimulation. Importantly, we found that expression of brain IPMK, which is necessary for mTOR/Akt signaling, remained decreased in HFD mice upon activation of AMPK. HFD mouse hippocampus exhibited increased expression of serine-phosphorylated insulin receptor substrate 1 (IRS1-pS616), a marker of insulin resistance, as well as decreased expression of PSD-95, a scaffolding protein enriched in post-synaptic densities, and synaptopodin, an actin-associated protein enriched in spine apparatuses. Spatial working memory was impaired as assessed by decreased spontaneous alternation in a T-maze. These findings indicate that HFD is associated with telencephalic insulin resistance and deleterious effects on synaptic integrity and cognitive behaviors. PMID:24686304

  8. Aeroacoustic Data for a High Reynolds Number Axisymmetric Subsonic Jet

    NASA Technical Reports Server (NTRS)

    Ponton, Michael K.; Ukeiley, Lawrence S.; Lee, Sang W.

    1999-01-01

    The near field fluctuating pressure and aerodynamic mean flow characteristics of a cold subsonic jet issuing from a contoured convergent nozzle are presented. The data are presented for nozzle exit Mach numbers of 0.30, 0.60, and 0.85 at a constant jet stagnation temperature of 104 F. The fluctuating pressure measurements were acquired via linear and semi-circular microphone arrays and the presented results include plots of narrowband spectra, contour maps, streamwise/azimuthal spatial correlations for zero time delay, and cross-spectra of the azimuthal correlations. A pitot probe was used to characterize the mean flow velocity by assuming the subsonic flow to be pressure-balanced with the ambient field into which it exhausts. Presented are mean flow profiles and the momentum thickness of the free shear layer as a function of streamwise position.

  9. Convection in an ideal gas at high Rayleigh numbers.

    PubMed

    Tilgner, A

    2011-08-01

    Numerical simulations of convection in a layer filled with ideal gas are presented. The control parameters are chosen such that there is a significant variation of density of the gas in going from the bottom to the top of the layer. The relations between the Rayleigh, Peclet, and Nusselt numbers depend on the density stratification. It is proposed to use a data reduction which accounts for the variable density by introducing into the scaling laws an effective density. The relevant density is the geometric mean of the maximum and minimum densities in the layer. A good fit to the data is then obtained with power laws with the same exponent as for fluids in the Boussinesq limit. Two relations connect the top and bottom boundary layers: The kinetic energy densities computed from free fall velocities are equal at the top and bottom, and the products of free fall velocities and maximum horizontal velocities are equal for both boundaries. PMID:21929106

  10. Numerical simulation of high Reynolds number bubble motion

    SciTech Connect

    McLaughlin, J.B.

    1995-12-31

    This paper presents the results of numerical simulations of bubble motion. All the results are for single bubbles in unbounded fluids. The liquid phase is quiescent except for the motion created by the bubble, which is axisymmetric. The main focus of the paper is on bubbles that are of order 1 mm in diameter in water. Of particular interest is the effect of surfactant molecules on bubble motion. Results for the {open_quotes}insoluble surfactant{close_quotes} model will be presented. These results extend research by other investigators to finite Reynolds numbers. The results indicate that, by assuming complete coverage of the bubble surface, one obtains good agreement with experimental observations of bubble motion in tap water. The effect of surfactant concentration on the separation angle is discussed.

  11. High Rayleigh number simulations in a slender laterally periodic domain

    NASA Astrophysics Data System (ADS)

    Verzicco, Roberto; van der Poel, Erwin; Lohse, Detlef

    2015-11-01

    The results of three-dimensional DNS simulations of Rayleigh-Bénard convection with Ra up to 1013 in a laterally periodic geometry with progressively decreasing aspect-ratios are presented. We show global quantities such as the heat transport as well as local time-averages and vertical profiles. It is observed that the heat transport for laterally unconfined geometries can be computed at relatively small aspect-ratios whose value decreases with Rayleigh number. This is beneficial in terms of computational cost, as the total simulated domain gets smaller. The boundary layers profiles are studied and movies of horizontal cross-section of the bulk and the boundary layer are shown.

  12. Behavioral and neurochemical abnormalities after exposure to low doses of high-energy iron particles.

    PubMed

    Hunt, W A; Joseph, J A; Rabin, B M

    1989-01-01

    Exposure of rats to high-energy iron particles (600 MeV/amu) has been found to alter behavior after doses as low as 10 rads. The performance of a task that measures upper body strength was significantly degraded after irradiation. In addition, an impairment in the regulation of dopamine release in the caudate nucleus (a motor center in the brain), lasting at least 6 months, was also found and correlated with the performance deficits. A general indication of behavioral toxicity and an index of nausea and emesis, the conditioned taste aversion, was also evident. The sensitivity to iron particles was 10-600 times greater than to gamma photons. These results suggest that behavioral and neurobiological damage may be a consequence of exposure to low doses of heavy particles and that this possibility should be extensively studied. PMID:11537313

  13. Behavioral and neurochemical abnormalities after exposure to low doses of high-energy iron particles

    NASA Astrophysics Data System (ADS)

    Hunt, Walter A.; Joseph, James A.; Rabin, Bernard M.

    Exposure of rats to high-energy iron particles (600 MeV/amu) has been found to alter behavior after doses as low as 10 rads. The performance of a task that measures upper body strength was significantly degraded after irradiation. In addition, an impairment in the regulation of dopamine release in the caudate nucleus (a motor center in the brain), lasting at least 6 months, was also found and correlated with the performance deficits. A general indication of behavioral toxicity and an index of nausea and emesis, the conditioned taste aversion, was also evident. The sensitivity to iron particles was 10-600 times greater than to gamma photons. These results suggest that behavioral and neurobiological damage may be a consequence of exposure to low doses of heavy particles and that this possibility should be extensively studied.

  14. Current source imaging for high spatial resolution magnetocardiography in normal and abnormal rat cardiac muscles

    NASA Astrophysics Data System (ADS)

    Uchida, S.; Iramina, K.; Goto, K.; Ueno, S.

    2000-05-01

    The purpose of our study was to identify the current source produced by acute ischemia and infarction. We measured magnetocardiograms (MCG) and electrocardiograms (ECG) of five male rats using a high-resolution dc superconducting quantum interference device gradiometer in a magnetically shielded room after performing coronary artery occlusion. The spatial resolution of the detecting magnetic field of our system is higher than the typical system, thus permitting the measurement of magnetic fields in small animals. Distribution of the magnetic fields B(t) and distribution of |rot B(t)|, which corresponded to the distribution of the current source, were imaged by 12-channel MCGs. As a result, the distribution of current source changes in the affected area of the myocardium during the ST segment, and amplitude of the peak significantly increased after occlusion. Our system can be used to help clarify the mechanism of the ST shift related to severe heart disease.

  15. Behavioral and neurochemical abnormalities after exposure to low doses of high-energy iron particles

    SciTech Connect

    Hunt, W.A.; Joseph, J.A.; Rabin, B.M.

    1989-01-01

    Exposure of rats to high-energy iron particles (600 MeV/amu) has been found to alter behavior after doses as low as 10 rads. The performance of a task that measures upper body strength was significantly degraded after irradiation. In addition, an impairment in the regulation of dopamine release in the caudate nucleus (a motor center in the brain), lasting at least 6 months, was also found and correlated with the performance deficits. A general indication of behavioral toxicity and an index of nausea and emesis, the conditioned taste aversion, was also evident. The sensitivity to iron particles was 10-600 times greater than to gamma photons. These results suggest that behavioral and neurobiological damage may be a consequence of exposure to low doses of heavy particles and that this possibility should be extensively studied.

  16. Parametric Investigation of a High-Lift Airfoil at High Reynolds Numbers

    NASA Technical Reports Server (NTRS)

    Lin, John C.; Dominik, Chet J.

    1997-01-01

    A new two-dimensional, three-element, advanced high-lift research airfoil has been tested in the NASA Langley Research Center s Low-Turbulence Pressure Tunnel at a chord Reynolds number up to 1.6 x 107. The components of this high-lift airfoil have been designed using a incompressible computational code (INS2D). The design was to provide high maximum-lift values while maintaining attached flow on the single-segment flap at landing conditions. The performance of the new NASA research airfoil is compared to a similar reference high-lift airfoil. On the new high-lift airfoil the effects of Reynolds number on slat and flap rigging have been studied experimentally, as well as the Mach number effects. The performance trend of the high-lift design is comparable to that predicted by INS2D over much of the angle-of-attack range. However, the code did not accurately predict the airfoil performance or the configuration-based trends near maximum lift where the compressibility effect could play a major role.

  17. Sasa quelpaertensis leaf extract improves high fat diet-induced lipid abnormalities and regulation of lipid metabolism genes in rats.

    PubMed

    Kim, Jina; Kim, Yoo-Sun; Lee, Hyun Ah; Lim, Ji Ye; Kim, Mina; Kwon, Oran; Ko, Hee-Chul; Kim, Se-Jae; Shin, Jae-Ho; Kim, Yuri

    2014-05-01

    Sasa quelpaertensis is a bamboo leaf that is only grown on Jeju Island in South Korea. It is used as a bamboo tea that is consumed for therapeutic purposes, particularly for its anti-diabetic, diuretic, and anti-inflammatory effects. This study investigated the effect of S. quelpaertensis leaf extract (SQE) on high fat-induced lipid abnormalities and regulation of lipid metabolism-related gene expressions in rats. SQE supplementation significantly decreased the levels of plasma triglycerides, total cholesterol, and low-density lipoprotein cholesterol as well as the atherogenic index. SQE restored levels of plasma high-density lipoprotein cholesterol, which were lowered by a high fat diet. Plasma and cardiac resistin levels were also significantly decreased by SQE supplementation. In adipose tissue, mRNA levels of CAAT/enhancer-binding protein β (C/EBPβ) were suppressed in the SQE group. SQE supplementation decreased the accumulation of lipid droplets, inflammatory cell infiltrations, levels of triglycerides, and total lipids in the liver and effectively down-regulated expression of sterol regulatory element binding protein-1 (SREBP-1), fatty acid synthetase (FAS), and uncoupling protein 2 (UCP-2). These results suggest that SQE may be a potential treatment for high fat-related disorders by improving lipid profiles and modulating lipid metabolism. PMID:24738745

  18. Elastic turbulence in high Reynolds number polymer drag reduced flows

    NASA Astrophysics Data System (ADS)

    Dubief, Yves; White, Christopher

    2011-11-01

    The present study discusses the existence of small scale dynamics resembling elastic turbulence in polymeric transitional and maximum drag reduction (MDR) flows. The observed flow patterns are driven by elastic stress and occur in regions of very low turbulence found before and after the breakdown of nonlinear instabilities in polymeric transitional flows leading to MDR. A state of polymer-dominated spanwise instabilities was found, resulting in a structure of the wall shear quite different than the structures observed in transitional Newtonian flow. Similar instabilities are observed in the wake of the head of hairpin vortices in simulated MDR flows, an extended region of extensional flow of the order of the Kolmogorov scale in the normal direction. The important Reynolds number is not that of flow (Reτ = 300 and 600 for the Newtonian flows) but that of the local turbulent flow, which according to Kolmogorov approaches unity in the above mentioned flows, a reasonable magnitude for elastic turbulence. The existence of small scale elastic turbulence in transitional and MDR flows explains the phenomenon of early turbulence first observed in the 70s and challenges the notion that, in drag reduced flows, the energy flows only from large to small scales and never goes back from polymers to flow.

  19. Hodograph design of lifting airfoils with high critical mach numbers

    NASA Astrophysics Data System (ADS)

    Kropinski, M. C. A.; Schwendeman, D. W.; Cole, J. D.

    1995-05-01

    We wish to construct airfoils that have the highest free-stream Mach number M ∞ for a given set of geometric constraints for which the flow is nowhere supersonic. Nonlifting airfoils which maximize M ∞ for a given thickness ratio δ are known to possess long sonic segments at their critical speed. To construct lifting airfoils, we proceed under the conjecture that the optimal airfoil satisfying a given set of constraints is the one possessing the longest possible arc length of sonic velocity. A boundary-value problem is formulated in the hodograph plane using transonic small-disturbance theory whose solution determines an airfoil with long sonic arcs. For small lift coefficients, the hodograph domain covers two Riemann sheets and a finite-difference method is used to solve the boundary-value problem on this domain. A numerical integration of the solution around the boundary yields an airfoil shape, and three examples are discussed. The performance of these airfoils is compared with standard airfoils having the same lift coefficient and δ, and it is shown that the calculated airfoils have a 6% 10% increase in critical M ∞.

  20. Somatic Copy Number Abnormalities and Mutations in PI3K/AKT/mTOR Pathway Have Prognostic Significance for Overall Survival in Platinum Treated Locally Advanced or Metastatic Urothelial Tumors

    PubMed Central

    Bellmunt, Joaquim; Werner, Lillian; Leow, Jeffrey J.; Mullane, Stephanie A.; Fay, André P.; Riester, Markus; Van Hummelen, Paul; Taplin, Mary-Ellen; Choueiri, Toni K.; Van Allen, Eliezer; Rosenberg, Jonathan

    2015-01-01

    Background An integrative analysis was conducted to identify genomic alterations at a pathway level that could predict overall survival (OS) in patients with advanced urothelial carcinoma (UC) treated with platinum-based chemotherapy. Patients and Methods DNA and RNA were extracted from 103 formalin-fixed paraffin embedded (FFPE) invasive high-grade UC samples and were screened for mutations, copy number variation (CNV) and gene expression analysis. Clinical data were available from 85 cases. Mutations were analyzed by mass-spectrometry based on genotyping platform (Oncomap 3) and genomic imbalances were detected by comparative genomic hybridization (CGH) analysis. Regions with threshold of log2 ratio ≥0.4, or ≤0.6 were defined as either having copy number gain or loss and significantly recurrent CNV across the set of samples were determined using a GISTIC analysis. Expression analysis on selected relevant UC genes was conducted using Nanostring. To define the co-occurrence pattern of mutations and CNV, we grouped genomic events into 5 core signal transduction pathways: 1) TP53 pathway, 2) RTK/RAS/RAF pathway, 3) PI3K/AKT/mTOR pathway, 4) WNT/CTNNB1, 5) RB1 pathway. Cox regression was used to assess pathways abnormalities with survival outcomes. Results 35 samples (41%) harbored mutations on at least one gene: TP53 (16%), PIK3CA (9%), FGFR3 (2%), HRAS/KRAS (5%), and CTNNB1 (1%). 66% of patients had some sort of CNV. PIK3CA/AKT/mTOR pathway alteration (mutations+CNV) had the greatest impact on OS (p=0.055). At a gene level, overexpression of CTNNB1 (p=0.0008) and PIK3CA (p=0.02) were associated with shorter OS. Mutational status on PIK3CA was not associated with survival. Among other individually found genomic alterations, TP53 mutations (p=0.07), mTOR gain (p=0.07) and PTEN overexpression (p=0.08) have a marginally significant negative impact on OS. Conclusions Our study suggests that targeted therapies focusing on the PIK3CA/AKT/mTOR pathway genomic

  1. Normalizations of High Taylor Reynolds Number Power Spectra

    NASA Astrophysics Data System (ADS)

    Puga, Alejandro; Koster, Timothy; Larue, John C.

    2014-11-01

    The velocity power spectrum provides insight in how the turbulent kinetic energy is transferred from larger to smaller scales. Wind tunnel experiments are conducted where high intensity turbulence is generated by means of an active turbulence grid modeled after Makita's 1991 design (Makita, 1991) as implemented by Mydlarski and Warhaft (M&W, 1998). The goal of this study is to document the evolution of the scaling region and assess the relative collapse of several proposed normalizations over a range of Rλ from 185 to 997. As predicted by Kolmogorov (1963), an asymptotic approach of the slope (n) of the inertial subrange to - 5 / 3 with increasing Rλ is observed. There are three velocity power spectrum normalizations as presented by Kolmogorov (1963), Von Karman and Howarth (1938) and George (1992). Results show that the Von Karman and Howarth normalization does not collapse the velocity power spectrum as well as the Kolmogorov and George normalizations. The Kolmogorov normalization does a good job of collapsing the velocity power spectrum in the normalized high wavenumber range of 0 . 0002 <= κλ <= 0 . 4 while the George normalization does a better job in the normalized mid-wavenumber range of 15 <= κλ <= 25 . University of California, Irvine Research Fund.

  2. Isotopic and Hydrogeochemical Studies on Abnormally High Ammonium of Natural Origin in A Coastal Aquifer-aquitard System

    NASA Astrophysics Data System (ADS)

    Wang, Y.; Jiao, J. J.; Cherry, J.

    2010-12-01

    Excessive nitrogen concentration in water bodies is regarded as an environmental contamination because of its possible harm to human bodies and significant ecological effects. Previous studies commonly concerned on elevated nitrogen in water of anthropogenic origins, such as agricultural, domestic, sewage and industrial discharges, because people realize that it is necessary to manage negative influences of human being to the natural environment. Understanding contamination sources of nitrogen is crucial for both waste discharge management and pollutants cleanup. This study was aimed to 1) understand the spatial distribution of abnormally high ammonium groundwater in the Quaternary basalt aquifer in the Pearl River Delta (PRD), China; 2) to distinguish sources of recharge to the basalt aquifer; and 3) to identify the origin of the ammonium in the aquitard and aquifer system. Total 40 boreholes were drilled, and approximately 1000 deposit samples from the aquitard and over 200 groundwater samples from the Quaternary basalt aquifer were collected. A cluster of 7 piezometers was installed in Minzhong Town to study the hydraulic relationships between the aquitard and the basalt aquifer. The results demonstrated that the greater groundwater ammonium concentrations were preserved in the aquifer buried deeper. The ammonium concentration up to 390 mg/L was observed in the basalt sand and gravel Pleistocene aquifer of 20-50m deep, and this is the greatest concentration ever reported for natural groundwater globally. The Quaternary aquitard, which contained abundant sedimentary organic matter and was mainly composed of silt and clay, provided a strict anaerobic environment for sedimentary organic matter mineralization and ammonium preservation. Ammonium concentrations in the aquifer were predominantly controlled by the aquitard ammonium content. This naturally occurring abnormally high ammonium in the Quaternary sediments is areally extensive (over 1600 km2). Great

  3. Rayleigh Taylor instability of viscoelastic drops at high Weber numbers

    NASA Astrophysics Data System (ADS)

    Joseph, D. D.; Beavers, G. S.; Funada, T.

    2002-02-01

    Movies of the breakup of viscous and viscoelastic drops in the high-speed airstream behind a shock wave in a shock tube have been reported by Joseph, Belanger & Beavers (1999). They performed a Rayleigh Taylor stability analysis for the initial breakup of a drop of Newtonian liquid and found that the most unstable Rayleigh Taylor wave fits nearly perfectly with waves measured on enhanced images of drops from the movies, but the effects of viscosity cannot be neglected. Here we construct a Rayleigh Taylor stability analysis for an Oldroyd-B fluid using measured data for acceleration, density, viscosity and relaxation time [lambda]1. The most unstable wave is a sensitive function of the retardation time [lambda]2 which fits experiments when [lambda]2/[lambda]1 = O(10-3). The growth rates for the most unstable wave are much larger than for the comparable viscous drop, which agrees with the surprising fact that the breakup times for viscoelastic drops are shorter. We construct an approximate analysis of Rayleigh Taylor instability based on viscoelastic potential flow which gives rise to nearly the same dispersion relation as the unapproximated analysis.

  4. A survey of the three-dimensional high Reynolds number transonic wind tunnel

    NASA Technical Reports Server (NTRS)

    Takashima, K.; Sawada, H.; Aoki, T.

    1982-01-01

    The facilities for aerodynamic testing of airplane models at transonic speeds and high Reynolds numbers are surveyed. The need for high Reynolds number testing is reviewed, using some experimental results. Some approaches to high Reynolds number testing such as the cryogenic wind tunnel, the induction driven wind tunnel, the Ludwieg tube, the Evans clean tunnel and the hydraulic driven wind tunnel are described. The level of development of high Reynolds number testing facilities in Japan is discussed.

  5. Flow and Noise Control in High Speed and High Reynolds Number Jets Using Plasma Actuators

    NASA Technical Reports Server (NTRS)

    Samimy, M.; Kastner, J.; Kim, J.-H.; Utkin, Y.; Adamovich, I.; Brown, C. A.

    2006-01-01

    The idea of manipulating flow to change its characteristics is over a century old. Manipulating instabilities of a jet to increase its mixing and to reduce its radiated noise started in the 1970s. While the effort has been successful in low-speed and low Reynolds number jets, available actuators capabilities in terms of their amplitude, bandwidth, and phasing have fallen short in control of high-speed and high Reynolds number jets of practical interest. Localized arc filament plasma actuators have recently been developed and extensively used at Gas Dynamics and Turbulence Laboratory (GDTL) for control of highspeed and high Reynolds number jets. While the technique has been quite successful and is very promising, all the work up to this point had been carried out using small high subsonic and low supersonic jets from a 2.54 cm diameter nozzle exit with a Reynolds number of about a million. The preliminary work reported in this paper is a first attempt to evaluate the scalability of the technique. The power supply/plasma generator was designed and built in-house at GDTL to operate 8 actuators simultaneously over a large frequency range (0 to 200 kHz) with independent control over phase and duty cycle of each actuator. This allowed forcing the small jet at GDTL with azimuthal modes m = 0, 1, 2, 3, plus or minus 1, plus or minus 2, and plus or minus 4 over a large range of frequencies. This power supply was taken to and used, with minor modifications, at the NASA Nozzle Acoustic Test Rig (NATR). At NATR, 32 actuators were distributed around the 7.5 in. nozzle (a linear increase with nozzle exit diameter would require 60 actuators). With this arrangement only 8 actuators could operate simultaneously, thus limiting the forcing of the jet at NATR to only three azimuthal modes m = plus or minus 1, 4, and 8. Very preliminary results at NATR indicate that the trends observed in the larger NASA facility in terms of the effects of actuation frequency and azimuthal modes are

  6. Diagnostic accuracy of myocardial deformation indices for detecting high risk coronary artery disease in patients without regional wall motion abnormality

    PubMed Central

    Rostamzadeh, Alireza; Shojaeifard, Maryam; Rezaei, Yousef; Dehghan, Kasra

    2015-01-01

    Background: The prediction of coronary artery disease (CAD) by conventional echocardiographic measurements is principally based on the estimation of ejection fraction and regional wall motion abnormality (RWMA). This study aimed to determine whether strain echocardiography of left ventricle measured by velocity vector imaging (VVI) method could detect patients with a high-risk CAD. Methods: In a prospective study, a total of 119 consecutive patients who were assessed for eligibility were categorized into three groups: (1) without CAD as normal (n=59), (2) 1- or 2-vessel disease as low-risk (n=29), and (3) left main and/or 3-vessel disease as high-risk (n=31). The peaks of systolic strain and strain rate from 18 curves of apical views were averaged as global longitudinal strain and strain rate (GLS and GLSR), respectively; the 6 systolic peaks of strain and strain rate at base- and mid-ventricular of short axis views were averaged as mean radial strain rate (MRSR). Results: GLS, GLSR, and basal MRSR of left ventricle were significantly lower in the high-risk group (P=0.047, P=0.004 and P=0.030, respectively). Receiver operating characteristics curve showed that the optimal values of GLS, GLSR, and basal MRSR for detecting the severe CAD were -17%, -1 s-1, and 1.45 s-1 with the sensitivities of 77%, 71%, and 71% and the specificities of 63%, 67%, and 62%, respectively. Conclusion: Decrements in the GLS, GLSR, and basal MRSR of the left ventricle can detect the high-risk CAD cases among patients without RWMA at rest. PMID:26309603

  7. Normal number of CGG repeats in the FMR-1 gene and abnormal incorporation of fibrillin into the extracellular matrix in Lujan Syndrome

    SciTech Connect

    Greenhaw, G.A.; Stone, C.; Milewicz, D.

    1994-09-01

    Lujan syndrome is an X-linked condition that includes mild-to-moderate mental retardation, poor social integration, normal secondary sexual development with normal testicular size, generalized hypotonia, hypernasal voice and dolichostenomelia. Major cardiac complications and lens dislocation have not been reported although severe myopia may occur. All reported cases have had negative cytogenetic screening for fra(X) syndrome but establishing this constellation of findings as a distinctive entity has been difficult. We report 4 males in two sibships with clinical findings consistent with Lujan syndrome, normal karyotypes, negative cytogenetic screening for fra(X) syndrome and a normal number of CGG repeats in the FMR-1 gene. Dermal fibroblasts explanted from one of the affected males were used to study fibrillin synthesis secretion and extracellular matrix incorporation into microfibrils. Cells from the affected individual showed normal synthesis and secretion of fibrillin when compared to control cells, but the fibrillin was not incorporated into the extracellular matrix. These results suggest the presence of a gene on the X chromosome which may play a role in microfibril assembly and when deficient may disrupt the incorporation of fibrillin into microfibrils. This may be important not only in normal body morphogenesis but also in the development/function of the brain. More affected individuals are needed to investigate these findings further.

  8. Abnormal functional specialization within medial prefrontal cortex in high-functioning autism: a multi-voxel similarity analysis

    PubMed Central

    Meuwese, Julia D.I.; Towgood, Karren J.; Frith, Christopher D.; Burgess, Paul W.

    2009-01-01

    Multi-voxel pattern analyses have proved successful in ‘decoding’ mental states from fMRI data, but have not been used to examine brain differences associated with atypical populations. We investigated a group of 16 (14 males) high-functioning participants with autism spectrum disorder (ASD) and 16 non-autistic control participants (12 males) performing two tasks (spatial/verbal) previously shown to activate medial rostral prefrontal cortex (mrPFC). Each task manipulated: (i) attention towards perceptual versus self-generated information and (ii) reflection on another person's mental state (‘mentalizing'versus ‘non-mentalizing’) in a 2 × 2 design. Behavioral performance and group-level fMRI results were similar between groups. However, multi-voxel similarity analyses revealed strong differences. In control participants, the spatial distribution of activity generalized significantly between task contexts (spatial/verbal) when examining the same function (attention/mentalizing) but not when comparing different functions. This pattern was disrupted in the ASD group, indicating abnormal functional specialization within mrPFC, and demonstrating the applicability of multi-voxel pattern analysis to investigations of atypical populations. PMID:19174370

  9. Abnormal functional specialization within medial prefrontal cortex in high-functioning autism: a multi-voxel similarity analysis.

    PubMed

    Gilbert, Sam J; Meuwese, Julia D I; Towgood, Karren J; Frith, Christopher D; Burgess, Paul W

    2009-04-01

    Multi-voxel pattern analyses have proved successful in 'decoding' mental states from fMRI data, but have not been used to examine brain differences associated with atypical populations. We investigated a group of 16 (14 males) high-functioning participants with autism spectrum disorder (ASD) and 16 non-autistic control participants (12 males) performing two tasks (spatial/verbal) previously shown to activate medial rostral prefrontal cortex (mrPFC). Each task manipulated: (i) attention towards perceptual versus self-generated information and (ii) reflection on another person's mental state ('mentalizing'versus 'non-mentalizing') in a 2 x 2 design. Behavioral performance and group-level fMRI results were similar between groups. However, multi-voxel similarity analyses revealed strong differences. In control participants, the spatial distribution of activity generalized significantly between task contexts (spatial/verbal) when examining the same function (attention/mentalizing) but not when comparing different functions. This pattern was disrupted in the ASD group, indicating abnormal functional specialization within mrPFC, and demonstrating the applicability of multi-voxel pattern analysis to investigations of atypical populations. PMID:19174370

  10. High spatial range velocity measurements in a high Reynolds number turbulent boundary layer

    NASA Astrophysics Data System (ADS)

    de Silva, C. M.; Gnanamanickam, E. P.; Atkinson, C.; Buchmann, N. A.; Hutchins, N.; Soria, J.; Marusic, I.

    2014-02-01

    Here, we detail and analyse a multi-resolution particle image velocity measurement that resolves the wide range of scales prevalent in a zero pressure gradient turbulent boundary layer at high Reynolds numbers (up to Reτ ≈ 20 000). A unique configuration is utilised, where an array of eight high resolution cameras at two magnification levels are used simultaneously to obtain a large field of view, while still resolving the smaller scales prevalent in the flow. Additionally, a highly magnified field of view targeted at the near wall region is employed to capture the viscous sublayer and logarithmic region, with a spatial resolution of a few viscous length scales. Flow statistics from these measurements show good agreement with prior, well resolved hot-wire anemometry measurements. Analysis shows that the instantaneous wall shear stress can be reliably computed, which is historically known to be challenging in boundary layers. A statistical assessment of the wall shear stress shows good agreement with existing correlations, prior experimental and direct numerical simulation data, extending this view to much higher Reynolds numbers. Furthermore, conditional analysis using multiple magnification levels is detailed, to study near-wall events associated with high skin friction fluctuations and their associated overlaying structures in the log region. Results definitively show that the passage of very large-scale positive (or negative) velocity fluctuations are associated with increased (or reduced) small-scale variance in wall shear stress fluctuations.

  11. Reduction of low- and high-grade cervical abnormalities associated with high uptake of the HPV bivalent vaccine in Scotland

    PubMed Central

    Pollock, K G J; Kavanagh, K; Potts, A; Love, J; Cuschieri, K; Cubie, H; Robertson, C; Cruickshank, M; Palmer, T J; Nicoll, S; Donaghy, M

    2014-01-01

    Background: In Scotland, a national HPV immunisation programme began in 2008 for 12- to 13-year olds, with a catch-up campaign from 2008 to 2011 for those under the age of 18. To monitor the impact of HPV immunisation on cervical disease at the population level, a programme of national surveillance was established. Methods: We analysed colposcopy data from a cohort of women born between 1988 and 1992 who entered the Scottish Cervical Screening Programme (SCSP) and were aged 20–21 in 2008–2012. Results: By linking datasets from the SCSP and colposcopy services, we observed a significant reduction in diagnoses of cervical intraepithelial neoplasia 1 (CIN 1; RR 0.71, 95% CI 0.58 to 0.87; P=0.0008), CIN 2 (RR 0.5, 95% CI 0.4 to 0.63; P<0.0001) and CIN 3 (RR 0.45, 95% CI 0.35 to 0.58; P<0.0001) for women who received three doses of vaccine compared with unvaccinated women. Conclusions: To our knowledge, this is one of the first studies to show a reduction of low- and high-grade CIN associated with high uptake of the HPV bivalent vaccine at the population level. These data are very encouraging for countries that have achieved high HPV vaccine uptake. PMID:25180766

  12. A high-energy-density, high-Mach number single jet experiment

    SciTech Connect

    Hansen, J. F.; Dittrich, T. R.; Elliott, J. B.; Glendinning, S. G.; Cotrell, D. L.

    2011-08-15

    A high-energy-density, x-ray-driven, high-Mach number (M{>=} 17) single jet experiment shows constant propagation speeds of the jet and its bowshock into the late time regime. The jet assumes a characteristic mushroom shape with a stalk and a head. The width of the head and the bowshock also grow linearly in time. The width of the stalk decreases exponentially toward an asymptotic value. In late time images, the stalk kinks and develops a filamentary nature, which is similar to experiments with applied magnetic fields. Numerical simulations match the experiment reasonably well, but ''exterior'' details of the laser target must be included to obtain a match at late times.

  13. Association of high viral load and abnormal liver function with high aflatoxin B1–albumin adduct levels in HIV-positive Ghanaians: preliminary observations

    PubMed Central

    Jolly, P.E.; Shuaib, F.M.; Jiang, Y.; Preko, P.; Baidoo, J.; Stiles, J.K.; Wang, J.-S.; Phillips, T.D.; Williams, J.H.

    2012-01-01

    We examined the association between certain clinical factors and aflatoxin B1–albumin adduct (AF-ALB) levels in HIV-positive people. Plasma samples collected from 314 (155 HIV-positive and 159 HIV-negative) people were tested for AF-ALB levels, viral load, CD4+ T-cell count, liver function profile, malaria parasitaemia, and hepatitis B and C virus infections. HIV-positive participants were divided into high and low groups based on their median AF-ALB of 0.93 pmol mg−1 albumin and multivariable logistic and linear regression methods used to assess relationships between clinical conditions and AF-ALB levels. Multivariable logistic regression showed statistically significant increased odds of having higher HIV viral loads (OR=2.84; 95% CI=1.17–7.78) and higher direct bilirubin levels (OR=5.47; 95% CI=1.03–22.85) among HIV-positive participants in the high AF-ALB group. There were also higher levels of total bilirubin and lower levels of albumin in association with high AF-ALB. Thus, aflatoxin exposure may contribute to high viral loads and abnormal liver function in HIV-positive people and so promote disease progression. PMID:21749228

  14. Associations between sexually transmitted infections, high-risk human papillomavirus infection, and abnormal cervical Pap smear results in OB/GYN outpatients

    PubMed Central

    Kim, Tae Jin

    2016-01-01

    Objective This study aimed to examine the meaning and usefulness of sexually transmitted infection (STI) test when caring for patients who have abnormal cervical cytology and/or positive high-risk human papillomavirus (HPV) DNA test results. Methods Among patients who underwent liquid-based cervical cytology and HPV DNA tests at the Obstetrics and Gynecology outpatient clinic, 800 patients who showed abnormal cervical cytology were compared with 200 patients in the control group. Both groups were simultaneously tested via multiplex real-time polymerase chain reaction for seven types of STI-causative microorganisms. Results The positive rate of high-risk HPV infection in total STIs positive group was 1.47 times higher than that of total STIs negative group. The probability of a cytological diagnosis of a grade equal to or higher than atypical squamous cells-cannot exclude high grade squamous intraepithelial lesion (ASC-H) was significantly higher in patients testing positive for total STIs (1.46 times), Chlamydia trachomatis (3.21 times), or Mycoplasma genitalicum (3.58 times) than in those testing negative. The total STIs positive rate was significantly higher for those having a cytological diagnosis of a grade equal to or higher than atypical squamous cells of undetermined significance (ASC-US) when high-risk HPV test result was negative. Conclusion Correlations were present not only between STIs and high-risk HPV infection but also between abnormal cervical cytology and STIs. Therefore, additional evaluation of STIs will be helpful to appropriately diagnose and treat patients with abnormal cervical cytology, positive results on high-risk HPV DNA test, or a cytological diagnosis of ASC-US despite negative high-risk HPV DNA test result. PMID:27329197

  15. High and abnormal forms of aggression in rats with extremes in trait anxiety--involvement of the dopamine system in the nucleus accumbens.

    PubMed

    Beiderbeck, Daniela I; Reber, Stefan O; Havasi, Andrea; Bredewold, Remco; Veenema, Alexa H; Neumann, Inga D

    2012-12-01

    A better neurobiological understanding of high and abnormal aggression based on adequate animal models is essential for novel therapy and prevention. Selective breeding of rats for extremes in anxiety-related behavior resulted in two behavioral phenotypes with high and abnormal forms of aggression. Rats bred for low anxiety-related behavior (LAB) consistently show highest levels of aggression and little social investigation in the resident-intruder (RI) test, compared with non-selected low-aggressive (NAB) rats. High anxiety-related (HAB) rats also show higher levels of aggression than NAB rats, but to a lesser extent than LAB rats. Accordingly, extremes in inborn anxiety in both directions are linked to an increased aggression level. Further, both LAB and HAB, but not NAB males, display abnormal aggression (attacks towards vulnerable body parts, females or narcotized males), which is particularly prominent in LABs. Also, only in LAB rats, the nucleus accumbens (NAc) was found to be strongly activated in response to the RI test as reflected by increased c-fos and zif268 mRNA expression, and higher local dopamine release compared with NAB males, without differences in local dopamine receptor binding. Consequently, local pharmacological manipulation by infusion of an anesthetic (lidocaine, 20 μg/μl) or a dopamine D2 (haloperidol, 10 ng/μl), but not D1 (SCH-23390 10 ng/μl), receptor antagonist significantly reduced high aggression in LAB rats. Thus, LAB rats are an adequate model to study high and abnormal aggression. In LAB males, this is likely to be linked to hyper-activation of the reward system, as found in psychopathic patients. Specifically, activation of the accumbal dopamine system is likely to underlie the high aggression observed in LAB rats. PMID:22608548

  16. Is abnormal non-high-density lipoprotein cholesterol a gender-specific predictor for metabolic syndrome in patients with schizophrenia taking second-generation antipsychotics?

    PubMed

    Lin, Esther Ching-Lan; Shao, Wen-Chuan; Yang, Hsin-Ju; Yen, Miaofen; Lee, Sheng-Yu; Wu, Pei-Chun; Lu, Ru-Band

    2015-02-01

    Evidence supports an association between metabolic syndrome (MetS) and schizophrenia. However, specific risk factors for MetS and gender differences in patients with schizophrenia taking second-generation antipsychotics (SGAs) have not been well explored. A cross-sectional cohort of 329 Han Chinese patients was recruited in a psychiatric hospital in central Taiwan. Using the definitions of the International Diabetes Federation for Chinese, the prevalence of MetS was 23.7% (men: 25.7%; women: 21.2%). Logistic regression analyses showed that patients with a BMI ≥ 24 and an abnormal non-high-density lipoprotein cholesterol (non-HDL-C) were significantly (p < 0.001) more likely to develop MetS. A BMI ≥ 24 was a significant risk factor in men (OR: 6.092, p < 0.001) and women (OR: 5.886, p < 0.001). An abnormal non-HDL-C was a significant specific risk factor for men with MetS (OR: 4.127, p < 0.001), but not for women. This study supports a greater prevalence of MetS in patients with schizophrenia taking SGAs than in the general population. Abnormal BMI and non-HDL-C were significantly associated with developing MetS, and an abnormal non-HDL-C was a specific risk factor for men. Future development of specific interventions and regular monitoring for MetS is imperative for early identification and prevention. PMID:25034455

  17. Patients with MCI and N400 or P600 abnormalities are at very high risk for conversion to dementia

    PubMed Central

    Olichney, J.M.; Taylor, J.R.; Gatherwright, J.; Salmon, D.P.; Bressler, A.J.; Kutas, M.; Iragui-Madoz, V.J.

    2011-01-01

    Objective We sought cognitive event-related potential (ERP) biomarkers of disease progression and subsequent conversion to dementia in mild cognitive impairment (MCI). Background Two ERP components, the P600 and N400, are sensitive to abnormal episodic/declarative memory and semantic processing. When congruous category-exemplars are repeated, smaller P600s (relative to initial presentation) are normally elicited. Repetitions of semantically incongruous words yield smaller N400 amplitude. In mild Alzheimer disease (AD), abnormalities of both the N400 and P600 repetition effects are present, suggesting a wide-spread failure of synaptic plasticity. Methods Patients with amnestic MCI (n = 32) were longitudinally studied annually with an ERP paradigm in which semantically congruous (50%) and incongruous target words are repeated 10 to 140 seconds after initial presentation. ERP data were analyzed to contrast MCI-to-AD converters (within 3 years) vs nonconverters, using split-plot analyses of variance. Results A statistically significant P600 congruous word repetition effect was found only in the nonconverter group (F = 9.9, p = 0.005 vs MCI converters). This effect correlated with verbal memory measures. Repetition of incongruous words produced a significant N400 amplitude attenuation (across right-hemisphere sites) in nonconverters, but not in converters. Patients with MCI with abnormal/reduced N400 or P600 word repetition effects had an 87 to 88% likelihood of dementia within 3 years while those with normal/spared N400 and P600 repetition effects had only an 11 to 27% likelihood. Conclusions Abnormalities of the P600 or N400 in mild cognitive impairment are associated with an increased risk of subsequent conversion to Alzheimer disease (AD). These event-related potential components may offer useful biomarkers for the detection and staging of very early AD. PMID:18077800

  18. N-231 High Reynolds Number Channel I is a blowdown Facility that utilizes interchangeable test

    NASA Technical Reports Server (NTRS)

    1980-01-01

    N-231 High Reynolds Number Channel I is a blowdown Facility that utilizes interchangeable test sections and nozzles. The facility provides experimental support for the fluid mechanics research, including experimental verification of aerodynamic computer codes and boundary-layer and airfoil studies that require high Reynolds number simulation. (Tunnel 1)

  19. Morphological abnormalities in elasmobranchs.

    PubMed

    Moore, A B M

    2015-08-01

    A total of 10 abnormal free-swimming (i.e., post-birth) elasmobranchs are reported from The (Persian-Arabian) Gulf, encompassing five species and including deformed heads, snouts, caudal fins and claspers. The complete absence of pelvic fins in a milk shark Rhizoprionodon acutus may be the first record in any elasmobranch. Possible causes, including the extreme environmental conditions and the high level of anthropogenic pollution particular to The Gulf, are briefly discussed. PMID:25903257

  20. Irrecoverable pressure loss coefficients for two out-of-plane piping elbows at high Reynolds number

    SciTech Connect

    Coffield, R.D.; Hammond, R.B.; McKeown, P.T.

    1999-02-08

    Pressure drops of multiple piping elbows were experimentally determined for high Reynolds number flows. The testing described has been performed in order to reduce uncertainties in the currently used methods for predicting irrecoverable pressure losses and also to provide a qualification database for computational fluid dynamics (CFD) computer codes. The earlier high Reynolds number correlations had been based on extrapolations over several orders of magnitude in Reynolds number from where the original database existed. Recent single elbow test data shows about a factor of two lower elbow pressure loss coefficient (at 40x 106 Reynolds number) than those from current correlations. This single piping elbow data has been extended in this study to a multiple elbow configuration of two elbows that are 90o out-of-plane relative to each other. The effects of separation distance and Reynolds number have been correlated and presented in a form that can be used for design application. Contrary to earlier extrapolations from low Reynolds numbers (Re c 1.0x 106), a strong Reynolds number dependence was found to exist. The combination of the high Reynolds number single elbow data with the multiple elbow interaction effects measured in this study shows that earlier design correlations are conservative by significant margins at high Reynolds numbers. Qualification of CFD predictions with this new high Reynolds number database will help guide the need for additional high Reynolds number testing of other piping configurations. The study also included velocity measurements at several positions downstream of the first and second test elbows using an ultrasonic flowmeter. Reasonable agreement after the first test elbow was found relative to flow fields that are known to exist from low Reynolds number visual tests and also from CFD predictions. This data should help to qualify CFD predictions of the three-dimensional flow stream downstream of the second test elbow.

  1. High prevalence of cardiovascular and respiratory abnormalities in advanced, intensively treated (transplanted) myeloma: The case for ‘late effects’ screening and preventive strategies

    PubMed Central

    Samuelson, Clare; O'Toole, Laurence; Boland, Elaine; Greenfield, Diana; Ezaydi, Yousef; Ahmedzai, Sam H.; Snowden, John A.

    2016-01-01

    Objectives: Modern management of myeloma has significantly improved survival, with increasing numbers of patients living beyond a decade. However, little is known about the long-term cardiovascular and respiratory status of intensively treated and multiply relapsed survivors. Methods: We performed detailed cardiovascular and respiratory evaluations in patients with intensively treated, advanced but stable myeloma. All patients had received at least two lines of treatment, including at least one haematopoietic stem cell transplantation procedure, but had stable, controlled disease and were off active treatment at the time of evaluation. Results: Thirty-two patients with a median duration of 6 years (range 2–12) from original diagnosis of myeloma and three lines (range 2–6) of treatment were evaluated. Despite normal physical examination in the majority, there was a high prevalence of sub-clinical cardiac and respiratory dysfunction, reflected by abnormalities of electrocardiography (45%), echocardiography (50%), serum N-terminal pro-B-type natriuretic peptide level (NT-pro-BNP, 50%), and pulmonary function testing (45%). NT-pro-BNP level correlated negatively with quality of life (P = 0.012) and positively with serum ferritin (P = 0.027). Dyspnoea score correlated with BMI (P = 0.001). Risk factors for cardiovascular disease (obesity, hypertension, hyperlipidaemia, and hyperinsulinaemia) were common. Discussion: Even in the absence of overt clinical features, the majority of intensively treated long-term survivors of myeloma have established cardiovascular and/or respiratory dysfunction, above levels expected in the general population of a similar age. Conclusion: This study supports routine screening and lifestyle modification combined with primary and secondary preventive strategies to reduce cardiovascular and respiratory disease and to preserve quality of life in transplanted myeloma patients. PMID:27077780

  2. Irrecoverable pressure loss coefficients for a short radius of curvature piping elbow at high Reynolds numbers

    SciTech Connect

    Coffield, R.D.; Hammond, R.B.; Koczko, J.P.; McKeown, P.T.; Zirpoli, P.J.

    1998-06-01

    Pressure drops in a piping elbow are experimentally determined for high Reynolds number flows. The testing described has been performed in order to reduce uncertainties in the currently used design values for predicting irrecoverable pressure losses. The earlier high Reynolds number correlations had been based on extrapolations over several orders of magnitude in Reynolds number from where the original database existed. The test data shows about a factor of two lower elbow pressure loss coefficient (at 40 {times} 10{sup 6} Reynolds number) than those current correlations.

  3. Large Eddy Simulations of Kelvin Helmholtz instabilities at high Reynolds number stratified flows

    NASA Astrophysics Data System (ADS)

    Brown, Dana; Goodman, Lou; Raessi, Mehdi

    2015-11-01

    Simulations of Kelvin Helmholtz Instabilities (KHI) at high Reynolds numbers are performed using the Large Eddy Simulation technique. Reynolds numbers up to 100,000 are achieved using our model. The resulting data set is used to examine the effect of Reynolds number on various statistics, including dissipation flux coefficient, turbulent kinetic energy budget, and Thorpe length scale. It is shown that KHI are qualitatively different at high Re, up to and including the onset of vortex pairing and billow collapse and quantitatively different afterward. The effect of Richardson number is also examined. The results are discussed as they apply to ocean experiments.

  4. Aerodynamics and heat transfer investigations on a high Reynolds number turbine cascade

    NASA Technical Reports Server (NTRS)

    Schobeiri, Taher; Mcfarland, Eric; Yeh, Frederick

    1991-01-01

    The results of aerodynamic and heat transfer experimental investigations performed in a high Reynolds number turbine cascade test facility are analyzed. The experimental facility simulates the high Reynolds number flow conditions similar to those encountered in the Space Shuttle Main Engine. In order to determine the influence of Reynolds number on aerodynamic and thermal behavior of the blades, heat transfer coefficients were measured at various Reynolds numbers using liquid crystal temperature measurement technique. Potential flow calculation methods were used to predict the cascade pressure distributions. Boundary layer and heat transfer calculation methods were used with these pressure distributions to verify the experimental results.

  5. Abnormal pressure in hydrocarbon environments

    USGS Publications Warehouse

    Law, B.E.; Spencer, C.W.

    1998-01-01

    Abnormal pressures, pressures above or below hydrostatic pressures, occur on all continents in a wide range of geological conditions. According to a survey of published literature on abnormal pressures, compaction disequilibrium and hydrocarbon generation are the two most commonly cited causes of abnormally high pressure in petroleum provinces. In young (Tertiary) deltaic sequences, compaction disequilibrium is the dominant cause of abnormal pressure. In older (pre-Tertiary) lithified rocks, hydrocarbon generation, aquathermal expansion, and tectonics are most often cited as the causes of abnormal pressure. The association of abnormal pressures with hydrocarbon accumulations is statistically significant. Within abnormally pressured reservoirs, empirical evidence indicates that the bulk of economically recoverable oil and gas occurs in reservoirs with pressure gradients less than 0.75 psi/ft (17.4 kPa/m) and there is very little production potential from reservoirs that exceed 0.85 psi/ft (19.6 kPa/m). Abnormally pressured rocks are also commonly associated with unconventional gas accumulations where the pressuring phase is gas of either a thermal or microbial origin. In underpressured, thermally mature rocks, the affected reservoirs have most often experienced a significant cooling history and probably evolved from an originally overpressured system.

  6. Calculation of the vacuum Green's function valid for high toroidal mode number in tokamaks.

    NASA Astrophysics Data System (ADS)

    Chance, Morrell; Turnbull, Alan

    2005-10-01

    The present evaluation of the Green's function used for the magmetic scalar potential in vacuum calculations for axisymmetric geometry in the vacuum segments of gato, pest and other mhd stability codes has been found to be deficient for moderately high toroidal mode numbers. This was due to the loss of numerical precision arising from the upward recursion relation used for generating the functions to high mode numbers. The recursion is initiated from the complete elliptic integrals of the first and second kinds. To ameliorate this, a direct integration of the integral representation of the function was crafted to achieve the necessary high accuracy for moderately high mode numbers. At very high mode numbers the loss of numerical precision due to the oscillatory behavior of the integrand is further avoided by judiciously deforming the integration contour in the complex plane. Machine precision, roughly 14 -- 16 digits, accuracy can be achieved by using a combination of both these techniques.

  7. High Reynolds number analysis of an axisymmetric afterbody with flow separation

    NASA Technical Reports Server (NTRS)

    Carlson, John R.; Reubush, David E.

    1996-01-01

    The ability of a three-dimensional Navier-Stokes method, PAB3D, to predict nozzle afterbody flow at high Reynolds number was assessed. Predicted surface pressure coefficient distributions and integrated afterbody drag are compared with experimental data obtained from the NASA-Langley 0.3 m Transonic Cryogenic Tunnel. Predicted afterbody surface pressures matched experimental data fairly closely. The change in the pressure coefficient distribution with Reynolds number was slightly over-predicted. Integrated afterbody drag was typically high compared to the experimental data. The change in afterbody pressure drag with Reynolds number was fairly small. The predicted point of flow separation on the nozzle was slightly downstream of that observed from oilflow data at low Reynolds numbers and had a very slight Reynolds number dependence, moving slightly further downstream as Reynolds number increased.

  8. Genotype Distribution of Human Papillomavirus among Women with Cervical Cytological Abnormalities or Invasive Squamous Cell Carcinoma in a High-Incidence Area of Esophageal Carcinoma in China

    PubMed Central

    Wang, Yuanyuan; Wang, Shaohong; Shen, Jinhui; Peng, Yanyan; Chen, Lechuan; Mai, Ruiqin

    2016-01-01

    Data of HPV genotype including 16 high-risk HPV (HR-HPV) and 4 low-risk HPV from 38,397 women with normal cytology, 1341 women with cervical cytology abnormalities, and 223 women with ISCC were retrospectively evaluated by a hospital-based study. The prevalence of high-risk HPV (HR-HPV) was 6.51%, 41.83%, and 96.86% in women with normal cytology, cervical cytology abnormalities, and ISCC, respectively. The three most common HPV types were HPV-52 (1.76%), HPV-16 (1.28%), and HPV-58 (0.97%) in women with normal cytology, whereas the most prevalent HPV type was HPV-16 (16.85%), followed by HPV-52 (9.55%) and HPV-58 (7.83%) in women with cervical cytology abnormalities. Specifically, HPV-16 had the highest frequency in ASC-H (24.16%, 36/149) and HSIL (35.71%, 110/308), while HPV-52 was the most common type in ASC-US (8.28%, 53/640) and LSIL (16.80%, 41/244). HPV-16 (75.78%), HPV18 (10.31%), and HPV58 (9.87%) were the most common types in women with ISCC. These data might contribute to increasing the knowledge of HPV epidemiology and providing the guide for vaccine selection for women in Shantou. PMID:27610364

  9. Genotype Distribution of Human Papillomavirus among Women with Cervical Cytological Abnormalities or Invasive Squamous Cell Carcinoma in a High-Incidence Area of Esophageal Carcinoma in China.

    PubMed

    Wang, Yuanyuan; Wang, Shaohong; Shen, Jinhui; Peng, Yanyan; Chen, Lechuan; Mai, Ruiqin; Zhang, Guohong

    2016-01-01

    Data of HPV genotype including 16 high-risk HPV (HR-HPV) and 4 low-risk HPV from 38,397 women with normal cytology, 1341 women with cervical cytology abnormalities, and 223 women with ISCC were retrospectively evaluated by a hospital-based study. The prevalence of high-risk HPV (HR-HPV) was 6.51%, 41.83%, and 96.86% in women with normal cytology, cervical cytology abnormalities, and ISCC, respectively. The three most common HPV types were HPV-52 (1.76%), HPV-16 (1.28%), and HPV-58 (0.97%) in women with normal cytology, whereas the most prevalent HPV type was HPV-16 (16.85%), followed by HPV-52 (9.55%) and HPV-58 (7.83%) in women with cervical cytology abnormalities. Specifically, HPV-16 had the highest frequency in ASC-H (24.16%, 36/149) and HSIL (35.71%, 110/308), while HPV-52 was the most common type in ASC-US (8.28%, 53/640) and LSIL (16.80%, 41/244). HPV-16 (75.78%), HPV18 (10.31%), and HPV58 (9.87%) were the most common types in women with ISCC. These data might contribute to increasing the knowledge of HPV epidemiology and providing the guide for vaccine selection for women in Shantou. PMID:27610364

  10. Simulations of high-Mach-number collisionless perpendicular shocks in astrophysical plasmas

    NASA Technical Reports Server (NTRS)

    Quest, K. B.

    1985-01-01

    A problem of critical importance to space physics and astrophysics is the existence and properties of high-Mach-number shocks. Preliminary results of a simulation of a perpendicular shock with Alfven Mach number 22 are reported. It is shown that for sufficiently small electron resistivity the dissipation for this shock is provided by a periodic rather than time-stationary reflection of ions. The problem of electron heating and the extension to higher Mach numbers are discussed.

  11. Abnormalities in carbohydrate and lipid metabolisms in high-fructose dietfed insulin-resistant rats: amelioration by Catharanthus roseus treatments.

    PubMed

    Rasineni, Karuna; Bellamkonda, Ramesh; Singareddy, Sreenivasa Reddy; Desireddy, Saralakumari

    2013-09-01

    High intake of dietary fructose has been shown to exert a number of adverse metabolic effects in humans and experimental animals. The present study was proposed to elucidate the effect of Catharanthus roseus (C. roseus) leaf powder treatment on alterations in carbohydrate and lipid metabolisms in rats fed with high-fructose diet. Male Wistar rats of body weight around 180 g were divided into four groups, two of these groups (groups C and C+CR) were fed with standard pellet diet and the other two groups (groups F and F+CR) were fed with high-fructose (66 %) diet. C. roseus leaf powder suspension in water (100 mg/kg body weight/day) was administered orally to group C+CR and group F+CR. At the end of a 60-day experimental period, biochemical parameters related to carbohydrate and lipid metabolisms were assayed. C. roseus treatment completely prevented the fructose-induced increased body weight, hyperglycemia, and hypertriglyceridemia. Hyperinsulinemia and insulin resistance observed in group F was significantly decreased with C. roseus treatment in group F+CR. The alterations observed in the activities of enzymes of carbohydrate and lipid metabolisms and contents of hepatic tissue lipids in group F rats were significantly restored to near normal values by C. roseus treatment in group F+CR. In conclusion, our study demonstrates that C. roseus treatment is effective in preventing fructose-induced insulin resistance and hypertriglyceridemia while attenuating the fructose-induced alterations in carbohydrate and lipid metabolisms. This study suggests that the plant can be used as an adjuvant for the prevention and/or management of insulin resistance and disorders related to it. PMID:23334857

  12. Reynolds Number Effects on a Supersonic Transport at Subsonic High-Lift Conditions (Invited)

    NASA Technical Reports Server (NTRS)

    Owens, L.R.; Wahls, R. A.

    2001-01-01

    A High Speed Civil Transport configuration was tested in the National Transonic Facility at the NASA Langley Research Center as part of NASA's High Speed Research Program. The primary purposes of the tests were to assess Reynolds number scale effects and high Reynolds number aerodynamic characteristics of a realistic, second generation supersonic transport while providing data for the assessment of computational methods. The tests included longitudinal and lateral/directional studies at transonic and low-speed, high-lift conditions across a range of Reynolds numbers from that available in conventional wind tunnels to near flight conditions. Results are presented which focus on Reynolds number and static aeroelastic sensitivities of longitudinal characteristics at Mach 0.30 for a configuration without an empennage. A fundamental change in flow-state occurred between Reynolds numbers of 30 to 40 million, which is characterized by significantly earlier inboard leading-edge separation at the high Reynolds numbers. Force and moment levels change but Reynolds number trends are consistent between the two states.

  13. Ultrasonographic assessment of abnormal pregnancy.

    PubMed

    England, G C

    1998-07-01

    Ultrasonographic imaging is widely used in small animal practice for the diagnosis of pregnancy and the determination of fetal number. Ultrasonography can also be used to monitor abnormal pregnancies, for example, conceptuses that are poorly developed for their gestational age (and therefore are likely to fail), and pregnancies in which there is embryonic resorption or fetal abortion. An ultrasound examination may reveal fetal abnormalities and therefore alter the management of the pregnant bitch or queen prior to parturition. There are, however, a number of ultrasonographic features of normal pregnancies that may mimic disease, and these must be recognized. PMID:9698618

  14. An investigation of small scales of turbulence in a boundary layer at high Reynolds numbers

    NASA Technical Reports Server (NTRS)

    Wallace, James M.; Ong, L.; Balint, J.-L.

    1993-01-01

    The assumption that turbulence at large wave-numbers is isotropic and has universal spectral characteristics which are independent of the flow geometry, at least for high Reynolds numbers, has been a cornerstone of closure theories as well as of the most promising recent development in the effort to predict turbulent flows, viz. large eddy simulations. This hypothesis was first advanced by Kolmogorov based on the supposition that turbulent kinetic energy cascades down the scales (up the wave-numbers) of turbulence and that, if the number of these cascade steps is sufficiently large (i.e. the wave-number range is large), then the effects of anisotropies at the large scales are lost in the energy transfer process. Experimental attempts were repeatedly made to verify this fundamental assumption. However, Van Atta has recently suggested that an examination of the scalar and velocity gradient fields is necessary to definitively verify this hypothesis or prove it to be unfounded. Of course, this must be carried out in a flow with a sufficiently high Reynolds number to provide the necessary separation of scales in order unambiguously to provide the possibility of local isotropy at large wave-numbers. An opportunity to use our 12-sensor hot-wire probe to address this issue directly was made available at the 80'x120' wind tunnel at the NASA Ames Research Center, which is normally used for full-scale aircraft tests. An initial report on this high Reynolds number experiment and progress toward its evaluation is presented.

  15. Palpable pediatric thyroid abnormalities – diagnostic pitfalls necessitate a high index of clinical suspicion: a case report

    PubMed Central

    Klopper, Joshua P; McDermott, Michael T

    2007-01-01

    A 12-year-old girl presented with a 4 year history of an enlarged, firm thyroid gland. On exam, her thyroid was firm and fixed and an enlarged cervical lymph node was palpable as well. Though a thyroid ultrasound prior to referral was read as thyroiditis, clinical suspicion for thyroid carcinoma mandated continued investigation. The diagnosis of papillary thyroid cancer was established and her workup revealed lymph node metastases as well as a tremendous burden of pulmonary metastases. Pediatric thyroid cancer is extremely rare, but often presents with aggressive disease. Palpable thyroid abnormalities in an individual under 20-years-old should be viewed with suspicion and should be thoroughly investigated to rule out malignancy even in the face of negative diagnostic procedures. Though pediatric papillary thyroid cancer often presents with loco-regional and even distant metastatic disease, mortality rates in follow-up for as long as 20 years are very favorable. PMID:17587454

  16. [An acute severe heat stroke patient showing abnormal diffuse high intensity of the cerebellar cortex in diffusion weighted image: a case report].

    PubMed

    Fujioka, Yusuke; Yasui, Keizo; Hasegawa, Yasuhiro; Takahashi, Akira; Sobue, Gen

    2009-10-01

    A 47-year-old man was admitted to the hospital because of general convulsion, loss of consciousness and hyperthermia. A diagnosis of acute heat stroke was made clinically and neuroradiologically. As the consciousness level ameliorated, he developed severe abulia and mutism, then cerebellar ataxic syndrome (viz. truncal ataxia, hypermetria, ataxic speech and nystagmus). An MRI (diffusion weighted image; DWI) disclosed abnormal diffuse high signal intensity of the cerebellar cortex with reduced apparent diffusion coefficient (ADC). Two months later after the onset, truncal ataxia and dysarthria significantly improved, while dysmetria of the extremities rather worsened. At that time, the abnormal signal intensity of the cerebellar cortex disappeared, and the cerebellum became atrophic. The cerebellar blood flow was significantly decreased on brain SPECT (99mTc-ECD). The abnormal DWI signal intensity of the cerebellar cortex in the present patient may represent the cytotoxic edema of Purkinje cells resulting from heat stroke-related hyperthermia It is essential to repeat MRI examination for cerebellar pathology and to obtain better insight into sequelae in patients with acute heat stroke. Protirelin tartrate seemed to be valid for improvement of abulia in the present patient. Further study is indicated. PMID:19999144

  17. High Reynolds number and turbulence effects on aerodynamics and heat transfer in a turbine cascade

    NASA Technical Reports Server (NTRS)

    Yeh, Frederick C.; Hippensteele, Steven A.; Vanfossen, G. James; Poinsatte, Philip E.; Ameri, Ali

    1993-01-01

    Experimental data on pressure distribution and heat transfer on a turbine airfoil were obtained over a range of Reynolds numbers from 0.75 to 7.5 x 10 exp 6 and a range of turbulence intensities from 1.8 to about 15 percent. The purpose of this study was to obtain fundamental heat transfer and pressure distribution data over a wide range of high Reynolds numbers and to extend the heat transfer data base to include the range of Reynolds numbers encountered in the Space Shuttle main engine (SSME) turbopump turbines. Specifically, the study aimed to determine (1) the effect of Reynolds number on heat transfer, (2) the effect of upstream turbulence on heat transfer and pressure distribution, and (3) the relationship between heat transfer at high Reynolds numbers and the current data base. The results of this study indicated that Reynolds number and turbulence intensity have a large effect on both the transition from laminar to turbulent flow and the resulting heat transfer. For a given turbulence intensity, heat transfer for all Reynolds numbers at the leading edge can be correlated with the Frossling number developed for lower Reynolds numbers. For a given turbulence intensity, heat transfer for the airfoil surfaces downstream of the leading edge can be approximately correlated with a dimensionless parameter. Comparison of the experimental results were also made with a numerical solution from a two-dimensional Navier-Stokes code.

  18. The Building Blocks of High School Redesign. Info Brief. Number 49

    ERIC Educational Resources Information Center

    Ewing, Tom

    2007-01-01

    U.S. high schools are, with a number of notable exceptions, failing to prepare students adequately for futures as well-equipped and productive contributors to our society, whether as college students or as members of the workplace. This "Infobrief" focuses on three key elements of high school redesign proposed by Association for Supervision and…

  19. Multigrid solution of the convection-diffusion equation with high-Reynolds number

    SciTech Connect

    Zhang, Jun

    1996-12-31

    A fourth-order compact finite difference scheme is employed with the multigrid technique to solve the variable coefficient convection-diffusion equation with high-Reynolds number. Scaled inter-grid transfer operators and potential on vectorization and parallelization are discussed. The high-order multigrid method is unconditionally stable and produces solution of 4th-order accuracy. Numerical experiments are included.

  20. Spectroscopic diagnostics of superthermal electrons with high-number harmonic EC radiation in tokamak reactor plasmas

    NASA Astrophysics Data System (ADS)

    Minashin, P. V.; Kukushkin, A. B.

    2015-03-01

    A method of spectroscopic diagnostics of the average perpendicular-to-magnetic-field momentum of the superthermal component of the electron velocity distribution (EVD), based on the high-number-harmonic electron cyclotron (EC) radiation, is suggested for nuclear fusion-reactor plasmas under condition of a strong auxiliary heating (e.g. in tokamak DEMO, a next step after tokamak ITER). The method is based on solving an inverse problem for reconstruction of the EVD in parallel and perpendicular-to-magnetic-field components of electron momentum at high and moderate energies responsible for the emission of the high-number-harmonic EC radiation.

  1. High Stakes Testing and High School Completion. NBETPP Statements, Volume 1, Number 3.

    ERIC Educational Resources Information Center

    Clarke, Marguerite; Haney, Walter; Madaus, George

    This report examines how high stakes assessments affect dropout and high school completion rates. The focus is on five suggestive lines of evidence about this relationship. This evidence is drawn in part from studies done at Boston College or by researchers for the National Board on Educational Testing and Public Policy. The conclusion drawn is…

  2. Wind tunnel tests of two airfoils for wind turbines operating at high reynolds numbers

    SciTech Connect

    Sommers, D.; Tangler, J.

    2000-06-29

    The objectives of this study were to verify the predictions of the Eppler Airfoil Design and Analysis Code for Reynolds numbers up to 6 x 106 and to acquire the section characteristics of two airfoils being considered for large, megawatt-size wind turbines. One airfoil, the S825, was designed to achieve a high maximum lift coefficient suitable for variable-speed machines. The other airfoil, the S827, was designed to achieve a low maximum lift coefficient suitable for stall-regulated machines. Both airfoils were tested in the NASA Langley Low-Turbulence Pressure Tunnel (LTPT) for smooth, fixed-transition, and rough surface conditions at Reynolds numbers of 1, 2, 3, 4, and 6 x 106. The results show the maximum lift coefficient of both airfoils is substantially underpredicted for Reynolds numbers over 3 x 106 and emphasized the difficulty of designing low-lift airfoils for high Reynolds numbers.

  3. Wall-modeling for large-eddy simulation of high Reynolds number supersonic flows

    NASA Astrophysics Data System (ADS)

    Kawai, Soshi; Larsson, Johan; Lele, Sanjiva

    2010-11-01

    We present an idea of approximate wall-boundary-condition approach with dynamic procedure for large-eddy simulation of Mach 3 supersonic turbulent boundary layer at various Reynolds numbers (Reδ=2 x10^4, 10^5 and 10^6) on a flat plate. This wall-model is the extension of previous work by Wang and Moin [Phys. Fluid, 14, 2043 (2002)] for incompressible flows to compressible flows. We note that the present study is both the first extension of the dynamic concept to compressible flows and also the first test at high Reynolds number flows. The present study also revisits the issue of numerical errors near wall-region on outer-layer coarse LES mesh. The numerical results are compared with wall-resolved LES data (at low Reynolds number case) and available experimental data (at high Reynolds number case).

  4. High Incidence of Progressive Postnatal Cerebellar Enlargement in Costello Syndrome: Brain Overgrowth Associated with HRAS Mutations as the Likely Cause of Structural Brain and Spinal Cord Abnormalities

    PubMed Central

    Gripp, Karen W.; Hopkins, Elisabeth; Doyle, Daniel; Dobyns, William B.

    2010-01-01

    Costello syndrome is a rasopathy caused by germline mutations in the proto-oncogene HRAS. Its presentation includes failure-to-thrive with macrocephaly, characteristic facial features, hypertrophic cardiomyopathy, papillomata, malignant tumors, and cognitive impairment. In a systematic review we found absolute or relative macrocephaly (100%), ventriculomegaly (50%), and other abnormalities on brain and spinal cord imaging studies in 27/28 individuals. Posterior fossa crowding with cerebellar tonsillar herniation (CBTH) was noted in 27/28 (96%), and in 10/17 (59%) with serial studies posterior fossa crowding progressed. Sequelae of posterior fossa crowding and CBTH included hydrocephalus requiring shunt or ventriculostomy (25%), Chiari 1 malformation (32%) and syrinx formation (25%). Our data reveal macrocephaly with progressive frontal bossing and CBTH, documenting an ongoing process rather than a static congenital anomaly. Comparison of images obtained in young infants to subsequent studies demonstrated postnatal development of posterior fossa crowding. This process of evolving megalencephaly and cerebellar enlargement is in keeping with mouse model data, delineating abnormal genesis of neurons and glia, resulting in an increased number of astrocytes and enlarged brain volume. In Costello syndrome and macrocephaly-capillary malformation syndrome disproportionate brain growth is the main factor resulting in postnatal CBTH and Chiari 1 malformation. PMID:20425820

  5. Abnormal Head Position

    MedlinePlus

    ... cause. Can a longstanding head turn lead to any permanent problems? Yes, a significant abnormal head posture could cause permanent ... occipitocervical synostosis and unilateral hearing loss. Are there any ... postures? Yes. Abnormal head postures can usually be improved depending ...

  6. Urine - abnormal color

    MedlinePlus

    ... straw-yellow. Abnormally colored urine may be cloudy, dark, or blood-colored. Causes Abnormal urine color may ... red blood cells, or mucus in the urine. Dark brown but clear urine is a sign of ...

  7. Active Control of Flow Separation on a High-Lift System with Slotted Flap at High Reynolds Number

    NASA Technical Reports Server (NTRS)

    Khodadoust, Abdollah; Washburn, Anthony

    2007-01-01

    The NASA Energy Efficient Transport (EET) airfoil was tested at NASA Langley's Low- Turbulence Pressure Tunnel (LTPT) to assess the effectiveness of distributed Active Flow Control (AFC) concepts on a high-lift system at flight scale Reynolds numbers for a medium-sized transport. The test results indicate presence of strong Reynolds number effects on the high-lift system with the AFC operational, implying the importance of flight-scale testing for implementation of such systems during design of future flight vehicles with AFC. This paper describes the wind tunnel test results obtained at the LTPT for the EET high-lift system for various AFC concepts examined on this airfoil.

  8. Optimization of an Advanced Design Three-Element Airfoil at High Reynolds Numbers

    NASA Technical Reports Server (NTRS)

    Lin, John C.; Dominik, Chet J.

    1995-01-01

    New high-lift components have been designed for a three-element advanced high-lift research airfoil using a state-of-the-art computational method. The new components were designed with the aim to provide high maximum-lift values while maintaining attached flow on the single-segment flap at approach conditions. This three-element airfoil has been tested in the NASA Langley Low-Turbulence Pressure Tunnel at chord Reynolds number up to 16 million. The performance of the NASA research airfoil is compared to a reference advanced high-lift research airfoil. Effects of Reynolds number on slat and flap rigging have been studied experimentally. The performance trend of this new high-lift design is comparable to that predicted by the computational method over much of the angle of attack range. Nevertheless, the method did not accurately predict the airfoil performance or the configuration-based trends near maximum lift.

  9. Numerical and approximate solution of the high Reynolds number small separation problem

    NASA Technical Reports Server (NTRS)

    Davis, R. T.

    1976-01-01

    Several possible methods of solving the small separation problem at high Reynolds number are investigated. In addition to using analytical methods, there are several numerical approaches which are used. High Reynolds number laminar two dimensional problems are used for simplicity. A brief discussion is given of the finite difference methods since these methods are discussed in detail. Most of the emphasis is placed on developing an approximate integral method. As a model problem the supersonic compression ramp problem is chosen since several numerical solutions along with experimental data are available. The techniques discussed are modified and applied to other similar type wall geometries.

  10. Qualification of a Method to Calculate the Irrecoverable Pressure Loss in High Reynolds Number Piping Systems

    SciTech Connect

    Sigg, K. C.; Coffield, R. D.

    2002-09-01

    High Reynolds number test data has recently been reported for both single and multiple piping elbow design configurations at earlier ASME Fluid Engineering Division conferences. The data of these studies ranged up to a Reynolds number of 42 x 10[sup]6 which is significantly greater than that used to establish design correlations before the data was available. Many of the accepted design correlations, based on the lower Reynolds number data, date back as much as fifty years. The new data shows that these earlier correlations are extremely conservative for high Reynolds number applications. Based on the recent high Reynolds number information a new recommended method has been developed for calculating irrecoverable pressure loses in piping systems for design considerations such as establishing pump sizing requirements. This paper describes the recommended design approach and additional testing that has been performed as part of the qualification of the method. This qualification testing determined the irrecoverable pressure loss of a piping configuration that would typify a limiting piping section in a complicated piping network, i.e., multiple, tightly coupled, out-of-plane elbows in series under high Reynolds number flow conditions. The overall pressure loss measurements were then compared to predictions, which used the new methodology to assure that conservative estimates for the pressure loss (of the type used for pump sizing) were obtained. The recommended design methodology, the qualification testing and the comparison between the predictions and the test data are presented. A major conclusion of this study is that the recommended method for calculating irrecoverable pressure loss in piping systems is conservative yet significantly lower than predicted by early design correlations that were based on the extrapolation of low Reynolds number test data.

  11. A high order accurate finite element algorithm for high Reynolds number flow prediction

    NASA Technical Reports Server (NTRS)

    Baker, A. J.

    1978-01-01

    A Galerkin-weighted residuals formulation is employed to establish an implicit finite element solution algorithm for generally nonlinear initial-boundary value problems. Solution accuracy, and convergence rate with discretization refinement, are quantized in several error norms, by a systematic study of numerical solutions to several nonlinear parabolic and a hyperbolic partial differential equation characteristic of the equations governing fluid flows. Solutions are generated using selective linear, quadratic and cubic basis functions. Richardson extrapolation is employed to generate a higher-order accurate solution to facilitate isolation of truncation error in all norms. Extension of the mathematical theory underlying accuracy and convergence concepts for linear elliptic equations is predicted for equations characteristic of laminar and turbulent fluid flows at nonmodest Reynolds number. The nondiagonal initial-value matrix structure introduced by the finite element theory is determined intrinsic to improved solution accuracy and convergence. A factored Jacobian iteration algorithm is derived and evaluated to yield a consequential reduction in both computer storage and execution CPU requirements while retaining solution accuracy.

  12. Estimating copy numbers of alleles from population-scale high-throughput sequencing data

    PubMed Central

    2015-01-01

    Background With the recent development of microarray and high-throughput sequencing (HTS) technologies, a number of studies have revealed catalogs of copy number variants (CNVs) and their association with phenotypes and complex traits. In parallel, a number of approaches to predict CNV regions and genotypes are proposed for both microarray and HTS data. However, only a few approaches focus on haplotyping of CNV loci. Results We propose a novel approach to infer copy unit alleles and their numbers in each sample simultaneously from population-scale HTS data by variational Bayesian inference on a generative probabilistic model inspired by latent Dirichlet allocation, which is a well studied model for document classification problems. In simulation studies, we evaluated concordance between inferred and true copy unit alleles for lower-, middle-, and higher-copy number dataset, in which precision and recall were ≥ 0.9 for data with mean coverage ≥ 10× per copy unit. We also applied the approach to HTS data of 1123 samples at highly variable salivary amylase gene locus and a pseudogene locus, and confirmed consistency of the estimated alleles within samples belonging to a trio of CEPH/Utah pedigree 1463 with 11 offspring. Conclusions Our proposed approach enables detailed analysis of copy number variations, such as association study between copy unit alleles and phenotypes or biological features including human diseases. PMID:25707811

  13. Molecular Characterization of Chronic Lymphocytic Leukemia Patients with a High Number of Losses in 13q14

    PubMed Central

    Rodríguez, Ana Eugenia; Hernández, Jose Ángel; Benito, Rocío; Gutiérrez, Norma C.; García, Juan Luis; Hernández-Sánchez, María; Risueño, Alberto; Sarasquete, M. Eugenia; Fermiñán, Encarna; Fisac, Rosa; de Coca, Alfonso García; Martín-Núñez, Guillermo; de las Heras, Natalia; Recio, Isabel; Gutiérrez, Oliver; De Las Rivas, Javier; González, Marcos; Hernández-Rivas, Jesús M.

    2012-01-01

    Background Patients with chronic lymphocytic leukemia and 13q deletion as their only FISH abnormality could have a different outcome depending on the number of cells displaying this aberration. Thus, cases with a high number of 13q- cells (13q-H) had both shorter overall survival and time to first therapy. The goal of the study was to analyze the genetic profile of 13q-H patients. Design and Methods: A total of 102 samples were studied, 32 of which served as a validation cohort and five were healthy donors. Results Chronic lymphocytic leukemia patients with higher percentages of 13q- cells (>80%) showed a different level of gene expression as compared to patients with lower percentages (<80%, 13q-L). This deregulation affected genes involved in apoptosis and proliferation (BCR and NFkB signaling), leading to increased proliferation and decreased apoptosis in 13q-H patients. Deregulation of several microRNAs, such as miR-15a, miR-155, miR-29a and miR-223, was also observed in these patients. In addition, our study also suggests that the gene expression pattern of 13q-H cases could be similar to the patients with 11q- or 17p-. Conclusions This study provides new evidence regarding the heterogeneity of 13q deletion in chronic lymphocytic leukemia patients, showing that apoptosis, proliferation as well as miRNA regulation are involved in cases with higher percentages of 13q- cells. PMID:23152777

  14. Longxuetongluo Capsule Improves Erythrocyte Function against Lipid Peroxidation and Abnormal Hemorheological Parameters in High Fat Diet-Induced ApoE−/− Mice

    PubMed Central

    Zheng, Jiao; Liu, Binglin; Lun, Qixing; Yao, Weijuan; Zhao, Yunfang; Xiao, Wei; Huang, Wenzhe; Wang, Yonghua; Li, Jun; Tu, Pengfei

    2016-01-01

    Chinese dragon's blood, the red resin of Dracaena cochinchinensis, one of the renowned traditional medicines, has been used to facilitate blood circulation and disperse blood stasis for thousands of years. Phenolic compounds are considered to be responsible for its main biological activities. In this study, total phenolic compounds of Chinese dragon's blood were made into capsule (Longxuetongluo Capsule, LTC) and their effects on the abnormal hemorheological properties were examined by high fat diet (HFD) induced ApoE−/− mice. Compared to the model group, LTC recovered the abnormal hemorheological parameters in HFD-induced ApoE−/− mice by reducing whole blood viscosity (WBV) at high rate and improving erythrocyte function. In conclusion, LTC could ameliorate erythrocyte deformability and osmotic fragility through the reduction of lipid peroxidation on plasma and erythrocyte membranes in HFD-induced ApoE−/− mice, which supported the traditional uses of Chinese dragon's blood as an effective agent for improving blood microcirculation in hypercholesterolemia. PMID:26649134

  15. Relationships (II) of International Classification of High-resolution Computed Tomography for Occupational and Environmental Respiratory Diseases with ventilatory functions indices for parenchymal abnormalities

    PubMed Central

    TAMURA, Taro; SUGANUMA, Narufumi; HERING, Kurt G.; VEHMAS, Tapio; ITOH, Harumi; AKIRA, Masanori; TAKASHIMA, Yoshihiro; HIRANO, Harukazu; KUSAKA, Yukinori

    2015-01-01

    The International Classification of High-Resolution Computed Tomography (HRCT) for Occupational and Environmental Respiratory Diseases (ICOERD) is used to screen and diagnose respiratory illnesses. Using univariate and multivariate analysis, we investigated the relationship between subject characteristics and parenchymal abnormalities according to ICOERD, and the results of ventilatory function tests (VFT). Thirty-five patients with and 27 controls without mineral-dust exposure underwent VFT and HRCT. We recorded all subjects’ occupational history for mineral dust exposure and smoking history. Experts independently assessed HRCT using the ICOERD parenchymal abnormalities (Items) grades for well-defined rounded opacities (RO), linear and/or irregular opacities (IR), and emphysema (EM). High-resolution computed tomography showed that 11 patients had RO; 15 patients, IR; and 19 patients, EM. According to the multiple regression model, age and height had significant associations with many indices ventilatory functions such as vital capacity, forced vital capacity, and forced expiratory volume in 1 s (FEV1). The EM summed grades on the upper, middle, and lower zones of the right and left lungs also had significant associations with FEV1 and the maximum mid-expiratory flow rate. The results suggest the ICOERD notation is adequate based on the good and significant multiple regression modeling of ventilatory function with the EM summed grades. PMID:25810443

  16. Hypertension, Abnormal Cholesterol, and High Body Mass Index among Non-Hispanic Asian Adults: United States, 2011-2012

    MedlinePlus

    ... high total cholesterol among non-Hispanic Asian adults did not differ by sex, age, education, or foreign- ... Figure 3 ). The prevalence of high total cholesterol did not differ significantly by sex, age, education, or ...

  17. High-order lattice Boltzmann models for wall-bounded flows at finite Knudsen numbers

    NASA Astrophysics Data System (ADS)

    Feuchter, C.; Schleifenbaum, W.

    2016-07-01

    We analyze a large number of high-order discrete velocity models for solving the Boltzmann-Bhatnagar-Gross-Krook equation for finite Knudsen number flows. Using the Chapman-Enskog formalism, we prove for isothermal flows a relation identifying the resolved flow regimes for low Mach numbers. Although high-order lattice Boltzmann models recover flow regimes beyond the Navier-Stokes level, we observe for several models significant deviations from reference results. We found this to be caused by their inability to recover the Maxwell boundary condition exactly. By using supplementary conditions for the gas-surface interaction it is shown how to systematically generate discrete velocity models of any order with the inherent ability to fulfill the diffuse Maxwell boundary condition accurately. Both high-order quadratures and an exact representation of the boundary condition turn out to be crucial for achieving reliable results. For Poiseuille flow, we can reproduce the mass flow and slip velocity up to the Knudsen number of 1. Moreover, for small Knudsen numbers, the Knudsen layer behavior is recovered.

  18. A Study of Hypersonic Compression-Corner Flow at High Reynolds Numbers

    NASA Astrophysics Data System (ADS)

    Vetlutsky, V. N.; Ganimedov, V. L.

    2002-07-01

    To numerically solve the problem for the ramp flow at high Reynolds number, it is justified to use the classical Prandtl model and to part the flow into an inviscid region and a thin boundary layer. This model is based on a rigorous asymptotic theory and describes the flow the more accurately, the higher the Reynolds number is. Since a flow separation in a compression corner may occur, the present work deals with unsteady boundary-layer equations. The approximation error in discretization of boundary-layer equations is always smaller than the value of viscid terms since the Reynolds number can be eliminated from the equations by a suitable substitution of variables. Besides, the requirement for the sufficient number of points in the cross-flow direction can be fulfilled in the case of middle-class computers since the solution is being built in a narrow near-wall region.

  19. A review of some Reynolds number effects related to bodies at high angles of attack

    NASA Technical Reports Server (NTRS)

    Polhamus, E. C.

    1984-01-01

    A review of some effects of Reynolds number on selected aerodynamic characteristics of two- and three-dimensional bodies of various cross sections in relation to fuselages at high angles of attack at subsonic and transonic speeds is presented. Emphasis is placed on the Reynolds number ranges above the subcritical and angles of attack where lee side vortex flow or unsteady wake type flows predominate. Lists of references, arranged in subject categories, are presented with emphasis on those which include data over a reasonable Reynolds number range. Selected Reynolds number data representative of various aerodynamic flows around bodies are presented and analyzed and some effects of these flows on fuselage aerodynamic parameters are discussed.

  20. Effect of High Shock Number on Acute Complication Development After Extracorporeal Shockwave Lithotripsy

    PubMed Central

    Hadj-Moussa, Miriam

    2013-01-01

    Abstract Purpose We assessed whether high shock number is associated with higher rates of acute complication development after extracorporeal shockwave lithotripsy (SWL). Patients and Methods A retrospective chart review of 372 patients who underwent 436 SWL procedures at 24 kV using a Medstone STS-T lithotripter (Medstone International Inc., Aliso Viejo, CA) was conducted. Complications occurred within 4 weeks of SWL. Treatments were split into three cohorts based on shock number (<2400, 2401–4000, and >4000). Postoperative sequelae of patients who were stone free and those with residual stone were studied separately. Chi-square tests were used to evaluate the relationship between shock number cohort and postoperative complication development. Results SWL treatments recorded for each cohort were 158 (37.4%), 145 (34.4%), and 119 (28.2%), respectively. The short-term complication rate when SWL was successful was 8.3% overall. Complication rate for each cohort was 9.5% (11), 7.8% (5), and 7.2% (7), respectively. When SWL was successful, statistical analysis revealed no significant difference between complication rates and shock number cohort (P=0.63). Complications in patients with a residual stone occurred after 41.4% of treatments and trended upward with shock number cohort, but did not reach statistical significance (P=0.84). Conclusions At high voltage, high shock number was not shown to cause higher rates of short-term postoperative complications, as experienced by patients, when SWL was successful or resulted in a residual stone, yet complication rates associated with residual stone burden were approximately five times as common. Forgoing a higher shock number in the presence of a residual stone may therefore increase the risks of sequelae immediately after SWL. PMID:23537270

  1. Transition Documentation on a Three-Element High-Lift Configuration at High Reynolds Numbers: Analysis

    NASA Technical Reports Server (NTRS)

    Bertelrud, Arild; Anders, J. B. (Technical Monitor)

    2002-01-01

    A 2-D high-lift system experiment was conducted in August of 1996 in the Low Turbulence Pressure Tunnel at NASA Langley Research Center, Hampton, VA. The purpose of the experiment was to obtain transition measurements on a three element high-lift system for CFD code validation studies. A transition database has been created using the data from this experiment. The present report contains the analysis of the surface hot film data in terms of the transition locations on the three elements. It also includes relevant information regarding the pressure loads and distributions and the wakes behind the model to aid in the interpretation of the transition data. For some of the configurations the current pressure data has been compared with previous wind tunnel entries of the same model. The methodology used to determine the regions of transitional flow is outlined and each configuration tested has been analyzed. A discussion of interference effects, repeatability, and three-dimensional effects on the data is included.

  2. Development of a new correlation to calculate permeability for flows with high Knudsen number

    NASA Astrophysics Data System (ADS)

    Esmaeil, Dehdashti

    2016-02-01

    Flows with high Knudsen number play a prominent role in many engineering applications. The present study is an effort toward the simulation of flow with high Knudsen number using modified lattice Boltzmann method (LBM) through a porous medium in a channel. The effect of collision between molecules and solid walls, which is required to accurately simulate transition flow regime, is taken into account using a modified relaxation time. Slip velocity on the wall, which is another significant difficulty in simulating transition flow regime, is captured using the slip reflection boundary condition (SRBC). The geometry of porous medium is considered as in-line and staggered. The results are in good agreement with previous works. A new correlation is obtained between permeability, Knudsen number and porosity for flows in transition flow regimes.

  3. A RAPID METHOD FOR PRODUCTION OF HIGH NUMBERS OF PURIFIED CRYPTOSPORIDIUM PARVUM OOCYSTS

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Most procedures that have been described for purifying Cryptosporidium parvum oocysts are designed to either identify the parasites in clinical specimens or isolate oocysts from a small volume of feces from infected animals. The present study describes a rapid method for purifying high numbers of C...

  4. The George C. Marshall Space Flight Center High Reynolds Number Wind Tunnel Technical Handbook

    NASA Technical Reports Server (NTRS)

    Gwin, H. S.

    1975-01-01

    The High Reynolds Number Wind Tunnel at the George C. Marshall Space Flight Center is described. The following items are presented to illustrate the operation and capabilities of the facility: facility descriptions and specifications, operational and performance characteristics, model design criteria, instrumentation and data recording equipment, data processing and presentation, and preliminary test information required.

  5. Application of Magnetic Suspension and Balance Systems to Ultra-High Reynolds Number Facilities

    NASA Technical Reports Server (NTRS)

    Britcher, Colin P.

    1996-01-01

    The current status of wind tunnel magnetic suspension and balance system development is briefly reviewed. Technical work currently underway at NASA Langley Research Center is detailed, where it relates to the ultra-high Reynolds number application. The application itself is addressed, concluded to be quite feasible, and broad design recommendations given.

  6. Dynamics of high Weber number drops impacting on hydrophobic surfaces with closed micro-cells.

    PubMed

    Zhang, Rui; Hao, Pengfei; Zhang, Xiwen; He, Feng

    2016-06-29

    The impact dynamics and bouncing performance of high Weber number drops on hydrophobic surfaces with open and closed micro-cells are investigated. Central wetted rings are observed on both closed-cell and open-cell surfaces under high Weber number collisions, which are proposed to constitute the key element affecting the bouncing behaviour. It is found that the drops rebound on closed-cell surfaces where the central area is in the "hybrid wetting state" at high Weber numbers, while the drops adhere to the open-cell surfaces where the central region is in the Wenzel state. A theoretical model is developed to explain this interesting phenomenon, in which the liquid cannot reach the bottom of the closed-cell hydrophobic surfaces since the air stored in micro-cavities prevents the sliding motion of the liquid film and functions as a "gas spring" lifting the liquid lamella. This indicates that the hydrophobic surface with simple micro cavities can maintain the water-repellent characteristics under drop impacts at high Weber numbers. These findings are expected to be crucial to a fundamental understanding of the rapid collisions between drops and micro-structured surfaces, as well as a valuable strategy to guide the fabrication of novel super water-repellant and anti-icing surfaces. PMID:27306824

  7. Turbulence Model Comparisons and Reynolds Number Effects Over a High-Speed Aircraft at Transonic Speeds

    NASA Technical Reports Server (NTRS)

    Rivers, Melissa B.; Wahls, Richard A.

    1999-01-01

    This paper gives the results of a grid study, a turbulence model study, and a Reynolds number effect study for transonic flows over a high-speed aircraft using the thin-layer, upwind, Navier-Stokes CFL3D code. The four turbulence models evaluated are the algebraic Baldwin-Lomax model with the Degani-Schiff modifications, the one-equation Baldwin-Barth model, the one-equation Spalart-Allmaras model, and Menter's two-equation Shear-Stress-Transport (SST) model. The flow conditions, which correspond to tests performed in the NASA Langley National Transonic Facility (NTF), are a Mach number of 0.90 and a Reynolds number of 30 million based on chord for a range of angle-of-attacks (1 degree to 10 degrees). For the Reynolds number effect study, Reynolds numbers of 10 and 80 million based on chord were also evaluated. Computed forces and surface pressures compare reasonably well with the experimental data for all four of the turbulence models. The Baldwin-Lomax model with the Degani-Schiff modifications and the one-equation Baldwin-Barth model show the best agreement with experiment overall. The Reynolds number effects are evaluated using the Baldwin-Lomax with the Degani-Schiff modifications and the Baldwin-Barth turbulence models. Five angles-of-attack were evaluated for the Reynolds number effect study at three different Reynolds numbers. More work is needed to determine the ability of CFL3D to accurately predict Reynolds number effects.

  8. Focus on new perspectives in high-Rayleigh-number turbulent convection Focus on new perspectives in high-Rayleigh-number turbulent convection

    NASA Astrophysics Data System (ADS)

    Schumacher, Jörg; Bodenschatz, Eberhard

    2012-09-01

    Thermal convection in a gravitational field is the source of most large-scale flows on Earth, planets and stars. It is also used to heat houses or to cool passively with metal vanes, as for example in most electronic equipment. The driving force for thermal convection is buoyancy. When a fluid is heated it expands, i.e., it changes its mass density. If the fluid in a gravitational field and heating is applied in such a way that cold, dense fluid is on top of that which is warmer and lighter, the warm fluid will rise when the driving forces of buoyancy overcome viscous drag and thermal diffusion. The experimentally best defined and most studied example is Rayleigh-Bénard convection (RBC), where a horizontal fluid layer is heated from below and cooled from above. For an incompressible fluid and Boussinesq conditions, where due to modest temperature gradients only the linear temperature dependence of density governs the physics, two dimensionless parameters describe the physics. One is the Rayleigh number, Ra, which is proportional to the temperature difference across the fluid layer of thickness, d, and to d3, implying that high Ra can be achieved experimentally at modest temperature differences only with a large d. The other parameter is the Prandtl number, Pr, which describes the relative importance of the convective nonlinearities in the momentum and heat equations. The geometry and thermal boundary conditions of the experimental apparatus are other important factors. Experiments usually strive to realize the theoretically most easily studied boundary conditions, i.e. perfectly conducting top and bottom plates and insulating sidewalls. As mentioned above, situations with large Ra require large cell heights. In experiments, typical geometries chosen are mostly cylindrical, with aspect ratios Γ = diameter/height between 1/4 and 2. For RBC, the onset of convection in an infinitely extended layer between no-slip walls is independent of the Prandtl number and occurs

  9. The 2-micron plasmid as a nonselectable, stable, high copy number yeast vector

    NASA Technical Reports Server (NTRS)

    Ludwig, D. L.; Bruschi, C. V.

    1991-01-01

    The endogenous 2-microns plasmid of Saccharomyces cerevisiae has been used extensively for the construction of yeast cloning and expression plasmids because it is a native yeast plasmid that is able to be maintained stably in cells at high copy number. Almost invariably, these plasmid constructs, containing some or all 2-microns sequences, exhibit copy number levels lower than 2-microns and are maintained stably only under selective conditions. We were interested in determining if there was a means by which 2-microns could be utilized for vector construction, without forfeiting either copy number or nonselective stability. We identified sites in the 2-microns plasmid that could be used for the insertion of genetic sequences without disrupting 2-microns coding elements and then assessed subsequent plasmid constructs for stability and copy number in vivo. We demonstrate the utility of a previously described 2-microns recombination chimera, pBH-2L, for the manipulation and transformation of 2-microns as a pure yeast plasmid vector. We show that the HpaI site near the STB element in the 2-microns plasmid can be utilized to clone yeast DNA of at least 3.9 kb with no loss of plasmid stability. Additionally, the copy number of these constructs is as high as levels reported for the endogenous 2-microns.

  10. Large scale dynamics in a turbulent compressible rotor/stator cavity flow at high Reynolds number

    NASA Astrophysics Data System (ADS)

    Lachize, C.; Verhille, G.; Le Gal, P.

    2016-08-01

    This paper reports an experimental investigation of a turbulent flow confined within a rotor/stator cavity of aspect ratio close to unity at high Reynolds number. The experiments have been driven by changing both the rotation rate of the disk and the thermodynamical properties of the working fluid. This fluid is sulfur hexafluoride (SF6) whose physical properties are adjusted by imposing the operating temperature and the absolute pressure in a pressurized vessel, especially near the critical point of SF6 reached for T c = 45.58 ◦C, P c = 37.55 bar. This original set-up allows to obtain Reynolds numbers as high as 2 × 107 together with compressibility effects as the Mach number can reach 0.5. Pressure measurements reveal that the resulting fully turbulent flow shows both a direct and an inverse cascade as observed in rotating turbulence and in accordance with Kraichnan conjecture for 2D-turbulence. The spectra are however dominated by low-frequency peaks, which are subharmonics of the rotating disk frequency, involving large scale structures at small azimuthal wavenumbers. These modes appear for a Reynolds number around 105 and experience a transition at a critical Reynolds number Re c ≈ 106. Moreover they show an unexpected nonlinear behavior that we understand with the help of a low dimensional amplitude equations.

  11. Design and installation of a high Reynolds number recirculating water tunnel

    NASA Astrophysics Data System (ADS)

    Daniel, Libin

    The High-Reynolds Number Fluid Mechanics Laboratory has recently been established at Oklahoma State University (OSU). The three primary components of the laboratory are 1) a recirculating water tunnel, 2) a multiphase pipe flow facility, and 3) a multi-scale flow visualization system. This thesis focuses on the design and fabrication of the water tunnel, which will be used for high-Reynolds number turbulent boundary layer research. Two main design criteria for the water tunnel were to achieve a momentum thickness based Reynolds number in excess of 104 and to have high optical access to the flow surfaces in the test section. This is being achieved with a 1 m. long test section and a maximum flow speed of 10 m/s. This Reynolds number was targeted to bridge the gap between typical university water tunnels (103) and the world's largest water tunnel facilities (105). The water tunnel is powered by a 150 hp motor and a 4500 gpm capacity centrifugal pump. The water tunnel is designed for a maximum operating pressure of 40 psi. This will make the facility a low cost option to perform high-Reynolds number aerodynamic and hydrodynamic tests. Improved flow imaging capability is a major advantage to liquid based fluid facilities because of the increased density for seeding and reduced field-of-view for equivalent Reynolds number. The laboratory's state-of-the-art flow visualization system can be used for time-resolved and phase averaged stereo- particle-image-velocimetry (sPIV), laser-induced-fluorescence, and high-speed imaging. Design provisions are also made to allow a multi-phase loop to share the pump and motor configuration of this water tunnel facility. The major design decisions that went into the design of the water tunnel facility are discussed. The design considerations that were taken into account for the test section, flow conditioning sections and the entire flow loop are discussed in greater detail. The final configuration and the technical drawings of the water

  12. Instability of magnetized and differentially rotating stellar radiation zones with high magnetic Mach number

    NASA Astrophysics Data System (ADS)

    Rüdiger, G.; Schultz, M.; Kitchatinov, L. L.

    2016-03-01

    With applications to inner solar-type radiative zones, a linear theory is used to analyse the instability of a toroidal background field of dipolar parity, in the presence of density stratification, differential rotation and realistically small Prandtl numbers. The physical parameters are the Alfvén frequency ΩA, the global rotation rate Ω and the buoyancy frequency N with ΩA < Ω < N. Only the solutions for the wavelengths with the maximal growth rates are considered. If these scales are combined to estimate radial velocities, one finds that it hardly depends on the latitudinal shear and the magnetic Mach number. In the formulation of Schatzman the radial mixing of chemicals can be estimated as Re* = O(100) which indeed is necessary to dissipate the lithium in the solar tachocline with a time-scale of 1 Gyr. The calculated growth rates indicate a destabilization of the system for growing latitudinal shear except for small Mach numbers and antisolar shear. The ratio ε of the magnetic and the kinetic energy of the instability pattern only slightly depends on the shear but a strong dependence on the magnetic Mach number exists with ε ∝ Mm2. The effective magnetic Prandtl number reaches values O(103) so that for the stars with high magnetic Mach number the differential rotation decays much faster than the toroidal background field.

  13. Numerically abnormal chromosome constitutions in humans

    SciTech Connect

    1993-12-31

    Chapter 24, discusses numerically abnormal chromosome constitutions in humans. This involves abnormalities of human chromosome number, including polyploidy (when the number of sets of chromosomes increases) and aneuploidy (when the number of individual normal chromosomes changes). Chapter sections discuss the following chromosomal abnormalities: human triploids, imprinting and uniparental disomy, human tetraploids, hydatidiform moles, anomalies caused by chromosomal imbalance, 13 trisomy (D{sub 1} trisomy, Patau syndrome), 21 trisomy (Down syndrome), 18 trisomy syndrome (Edwards syndrome), other autosomal aneuploidy syndromes, and spontaneous abortions. The chapter concludes with remarks on the nonrandom participation of chromosomes in trisomy. 69 refs., 3 figs., 4 tabs.

  14. Analysis of gas turbine engines using water and oxygen injection to achieve high Mach numbers and high thrust

    NASA Technical Reports Server (NTRS)

    Henneberry, Hugh M.; Snyder, Christopher A.

    1993-01-01

    An analysis of gas turbine engines using water and oxygen injection to enhance performance by increasing Mach number capability and by increasing thrust is described. The liquids are injected, either separately or together, into the subsonic diffuser ahead of the engine compressor. A turbojet engine and a mixed-flow turbofan engine (MFTF) are examined, and in pursuit of maximum thrust, both engines are fitted with afterburners. The results indicate that water injection alone can extend the performance envelope of both engine types by one and one-half Mach numbers at which point water-air ratios reach 17 or 18 percent and liquid specific impulse is reduced to some 390 to 470 seconds, a level about equal to the impulse of a high energy rocket engine. The envelope can be further extended, but only with increasing sacrifices in liquid specific impulse. Oxygen-airflow ratios as high as 15 percent were investigated for increasing thrust. Using 15 percent oxygen in combination with water injection at high supersonic Mach numbers resulted in thrust augmentation as high as 76 percent without any significant decrease in liquid specific impulse. The stoichiometric afterburner exit temperature increased with increasing oxygen flow, reaching 4822 deg R in the turbojet engine at a Mach number of 3.5. At the transonic Mach number of 0.95 where no water injection is needed, an oxygen-air ratio of 15 percent increased thrust by some 55 percent in both engines, along with a decrease in liquid specific impulse of 62 percent. Afterburner temperature was approximately 4700 deg R at this high thrust condition. Water and/or oxygen injection are simple and straightforward strategies to improve engine performance and they will add little to engine weight. However, if large Mach number and thrust increases are required, liquid flows become significant, so that operation at these conditions will necessarily be of short duration.

  15. Immune Abnormalities in Patients with Autism.

    ERIC Educational Resources Information Center

    Warren, Reed P.; And Others

    1986-01-01

    A study of 31 autistic patients (3-28 years old) has revealed several immune-system abnormalities, including decreased numbers of T lymphocytes and an altered ratio of helper-to-suppressor T cells. Immune-system abnormalities may be directly related to underlying biologic processes of autism or an indirect reflection of the actual pathologic…

  16. Design and Predictions for High-Altitude (Low Reynolds Number) Aerodynamic Flight Experiment

    NASA Technical Reports Server (NTRS)

    Greer, Donald; Harmory, Phil; Krake, Keith; Drela, Mark

    2000-01-01

    A sailplane being developed at NASA Dryden Flight Research Center will support a high-altitude flight experiment. The experiment will measure the performance parameters or an airfoil at high altitudes (70,000 - 100,000 ft), low Reynolds numbers (2 x 10(exp 5) - 7 x 10(exp 5)), and high subsonic Mach numbers (0.5 and 0.65). The airfoil section lift and drag are determined from pilot and static pressure measurements. The locations of the separation bubble, Tollmien-Schlichting boundary-layer instability frequencies, and vortex shedding are measured from a hot-film strip. The details of the planned flight experiment are presented as well as several predictions of the airfoil performance.

  17. Design and Predictions for a High-Altitude (Low-Reynolds-Number) Aerodynamic Flight Experiment

    NASA Technical Reports Server (NTRS)

    Greer, Donald; Hamory, Phil; Krake, Keith; Drela, Mark

    1999-01-01

    A sailplane being developed at NASA Dryden Flight Research Center will support a high-altitude flight experiment. The experiment will measure the performance parameters of an airfoil at high altitudes (70,000 to 100,000 ft), low Reynolds numbers (200,000 to 700,000), and high subsonic Mach numbers (0.5 and 0.65). The airfoil section lift and drag are determined from pitot and static pressure measurements. The locations of the separation bubble, Tollmien-Schlichting boundary layer instability frequencies, and vortex shedding are measured from a hot-film strip. The details of the planned flight experiment are presented. Several predictions of the airfoil performance are also presented. Mark Drela from the Massachusetts Institute of Technology designed the APEX-16 airfoil, using the MSES code. Two-dimensional Navier-Stokes analyses were performed by Mahidhar Tatineni and Xiaolin Zhong from the University of California, Los Angeles, and by the authors at NASA Dryden.

  18. Porcine oocyte mtDNA copy number is high or low depending on the donor.

    PubMed

    Pedersen, Hanne Skovsgaard; Løvendahl, Peter; Larsen, Knud; Madsen, Lone Bruhn; Callesen, Henrik

    2016-08-01

    Oocyte capacity is relevant in understanding decreasing female fertility and in the use of assisted reproductive technologies in human and farm animals. Mitochondria are important to the development of a functionally good oocyte and the oocyte mtDNA copy number has been introduced as a useful parameter for prediction of oocyte competence. The aim of this study was to investigate: (i) if the oocyte donor has an influence on its oocyte's mtDNA copy number; and (ii) the relation between oocyte size and mtDNA copy number using pre- and postpubertal pig oocytes. Cumulus-oocyte complexes were collected from individual donor pigs. The oocytes were allocated into different size-groups, snap-frozen and single-oocyte mtDNA copy number was estimated by quantitative real-time PCR using the genes ND1 and COX1. Results showed that mean mtDNA copy number in oocytes from any individual donor could be categorized as either 'high' (≥100,000) or 'low' (<100,000) with no difference in threshold between pre- and postpubertal oocytes. No linear correlation was detected between oocyte size and mtDNA copy number within pre- and postpubertal oocytes. This study demonstrates the importance of the oocyte donor in relation to oocyte mtDNA copy number, irrespectively of the donor's puberty status and the oocyte's growth stage. Observations from this study facilitate both further investigations of the importance of mtDNA copy number and the unravelling of relations between different mitochondrial parameters and oocyte competence. PMID:26679989

  19. An experimental study of high Reynolds number turbulence in the atmosphere

    NASA Astrophysics Data System (ADS)

    Dhruva, Brindesh R.

    2000-11-01

    High Reynolds number turbulence in the atmospheric boundary layer has been investigated using constant temperature hot-wire anemometry. The Taylor microscale Reynolds numbers (Rλ) were typically between 5 × 103 at 2 meters in the salt flats of Western Utah and 2 × 104 at 35 meters on the meterological tower of Brookhaven National Laboratory in Long Island. The measurements were used to study the statistical properties of inertial range quantities, Reynolds stress and wind direction. The identification of possible self- similar behavior in the inertial range is a primary goal in turbulence research. To motivate the need for high Reynolds number measurements we demonstrate the Reynolds number effect on the existence and extent of the inertial range. We find that the inertial range is non-existent at typical laboratory Reynolds numbers. We thus turn to high Reynolds numbers and analyze the asymmetry in the probability distribution function (pdf) of the longitudinal velocity increment. We compute the scaling exponents of the positive and negative structure functions and find that the negative exponents are more anomalous than the positive ones. Furthermore, we quantify the contribution to the asymmetry-or the skewness-from different regions of the pdf. We find that the core region of the pdf is more or less symmetric and the skewness comes primarily from the rare large amplitude events contained in the tails of the pdf. We discuss this result in the context of the down-scale cascade of energy. Next it is shown that even at Rλ ~ 20,000 the structure functions do not scale unambiguously-although the situation is far better than that at low Reynolds numbers. By applying various filtering techniques and conditional sampling it is shown that this lack of strict scaling even at very high Reynolds numbers is due to large scale ``corrupting effects'' on the inertial range. We propose a plausible scheme to remove the large scale effects. Next, we characterize the

  20. Magnus effects at high angles of attack and critical Reynolds numbers

    NASA Technical Reports Server (NTRS)

    Seginer, A.; Ringel, M.

    1983-01-01

    The Magnus force and moment experienced by a yawed, spinning cylinder were studied experimentally in low speed and subsonic flows at high angles of attack and critical Reynolds numbers. Flow-field visualization aided in describing a flow model that divides the Magnus phenomenon into a subcritical region, where reverse Magnus loads are experienced, and a supercritical region where these loads are not encountered. The roles of the spin rate, angle of attack, and crossflow Reynolds number in determining the boundaries of the subcritical region and the variations of the Magnus loads were studied.

  1. An experimental documentation of trailing-edge flows at high Reynolds number

    NASA Technical Reports Server (NTRS)

    Viswanath, P. R.; Cleary, J. W.; Seegmiller, H. L.

    1983-01-01

    Experiments documenting attached trailing-edge and near-wake flows at high Reynolds numbers are described. A long, airfoil-like model was tested at subsonic and low transonic Mach numbers, and both symmetrical and asymmetrical flows with pressure gradients upstream of the trailing edge were investigated. Model surface pressures and detailed mean and turbulence flow qualities were measured in the vicinity of the trailing edge and in the near-wake. The data obtained are of sufficient quality and detail to be useful as test cases in assessing turbulence models and calculation methods.

  2. Brain abnormality segmentation based on l1-norm minimization

    NASA Astrophysics Data System (ADS)

    Zeng, Ke; Erus, Guray; Tanwar, Manoj; Davatzikos, Christos

    2014-03-01

    We present a method that uses sparse representations to model the inter-individual variability of healthy anatomy from a limited number of normal medical images. Abnormalities in MR images are then defined as deviations from the normal variation. More precisely, we model an abnormal (pathological) signal y as the superposition of a normal part ~y that can be sparsely represented under an example-based dictionary, and an abnormal part r. Motivated by a dense error correction scheme recently proposed for sparse signal recovery, we use l1- norm minimization to separate ~y and r. We extend the existing framework, which was mainly used on robust face recognition in a discriminative setting, to address challenges of brain image analysis, particularly the high dimensionality and low sample size problem. The dictionary is constructed from local image patches extracted from training images aligned using smooth transformations, together with minor perturbations of those patches. A multi-scale sliding-window scheme is applied to capture anatomical variations ranging from fine and localized to coarser and more global. The statistical significance of the abnormality term r is obtained by comparison to its empirical distribution through cross-validation, and is used to assign an abnormality score to each voxel. In our validation experiments the method is applied for segmenting abnormalities on 2-D slices of FLAIR images, and we obtain segmentation results consistent with the expert-defined masks.

  3. The small-scale dynamo: breaking universality at high Mach numbers

    NASA Astrophysics Data System (ADS)

    Schleicher, Dominik R. G.; Schober, Jennifer; Federrath, Christoph; Bovino, Stefano; Schmidt, Wolfram

    2013-02-01

    The small-scale dynamo plays a substantial role in magnetizing the Universe under a large range of conditions, including subsonic turbulence at low Mach numbers, highly supersonic turbulence at high Mach numbers and a large range of magnetic Prandtl numbers Pm, i.e. the ratio of kinetic viscosity to magnetic resistivity. Low Mach numbers may, in particular, lead to the well-known, incompressible Kolmogorov turbulence, while for high Mach numbers, we are in the highly compressible regime, thus close to Burgers turbulence. In this paper, we explore whether in this large range of conditions, universal behavior can be expected. Our starting point is previous investigations in the kinematic regime. Here, analytic studies based on the Kazantsev model have shown that the behavior of the dynamo depends significantly on Pm and the type of turbulence, and numerical simulations indicate a strong dependence of the growth rate on the Mach number of the flow. Once the magnetic field saturates on the current amplification scale, backreactions occur and the growth is shifted to the next-larger scale. We employ a Fokker-Planck model to calculate the magnetic field amplification during the nonlinear regime, and find a resulting power-law growth that depends on the type of turbulence invoked. For Kolmogorov turbulence, we confirm previous results suggesting a linear growth of magnetic energy. For more general turbulent spectra, where the turbulent velocity scales with the characteristic length scale as uℓ∝ℓϑ, we find that the magnetic energy grows as (t/Ted)2ϑ/(1-ϑ), with t being the time coordinate and Ted the eddy-turnover time on the forcing scale of turbulence. For Burgers turbulence, ϑ = 1/2, quadratic rather than linear growth may thus be expected, as the spectral energy increases from smaller to larger scales more rapidly. The quadratic growth is due to the initially smaller growth rates obtained for Burgers turbulence. Similarly, we show that the characteristic

  4. Numerical simulations of high Knudsen number gas flows and microchannel electrokinetic liquid flows

    NASA Astrophysics Data System (ADS)

    Yan, Fang

    Low pressure and microchannel gas flows are characterized by high Knudsen numbers. Liquid flows in microchannels are characterized by non-conventional driving potentials like electrokinetic forces. The main thrust of the dissertation is to investigate these two different kinds of flows in gases and liquids respectively. High Knudsen number (Kn) gas flows were characterized by 'rarified' or 'microscale' behavior. Because of significant non-continuum effect, traditional CFD techniques are often inaccurate for analyzing high Kn number gas flows. The direct simulation Monte Carlo (DSMC) method offers an alternative to traditional CFD which retains its validity in slip and transition flow regimes. To validate the DSMC code, comparisons of simulation results with theoretical analysis and experimental data are made. The DSMC method was first applied to compute low pressure, high Kn flow fields in partially heated two dimensional channels. The effects of varying pressure, inlet flow and gas transport properties (Kn, Reynolds number, Re and the Prandtl number, Pr respectively) on the wall heat transfer (Nusselt number, Nu) were examined. The DSMC method was employed to explore mixing gas flows in two dimensional microchannels. Mixing of two gas streams (H2 and O2) was considered within a microchannel. The effect of the inlet-outlet pressure difference, the pressure ratio of the incoming streams and the accommodation coefficient of the solid wall on mixing length were all examined. Parallelization of a three-dimensional DSMC code was implemented using OpenMP procedure on a shared memory multi-processor computer. The parallel code was used to simulate 3D high Kn number Couette flow and the flow characteristics are found to be very different from their continuum counterparts. A mathematical model describing electrokinetically driven mass transport phenomena in microfabricated chip devices will also be presented. The model accounts for the principal physical phenomena affecting

  5. Measurements of the wall-normal velocity component in very high Reynolds number pipe flow

    NASA Astrophysics Data System (ADS)

    Vallikivi, Margit; Hultmark, Marcus; Smits, Alexander J.

    2012-11-01

    Nano-Scale Thermal Anemometry Probes (NSTAPs) have recently been developed and used to study the scaling of the streamwise component of turbulence in pipe flow over a very large range of Reynolds numbers. This probe has an order of magnitude higher spatial and temporal resolution than regular hot wires, allowing it to resolve small scale motions at very high Reynolds numbers. Here use a single inclined NSTAP probe to study the scaling of the wall normal component of velocity fluctuations in the same flow. These new probes are calibrated using a method that is based on the use of the linear stress region of a fully developed pipe flow. Results on the behavior of the wall-normal component of velocity for Reynolds numbers up to 2 million are reported. Supported under NR Grant N00014-09-1-0263 (program manager Ron Joslin) and NSF Grant CBET-1064257 (program manager Henning Winter).

  6. Operating characteristics of the Langley Mach 10 high Reynolds number helium tunnel

    NASA Technical Reports Server (NTRS)

    Watson, R. D.; Morris, D. J.; Fischer, M. C.

    1974-01-01

    Operating characteristics of the Langley Mach 10 high Reynolds number helium tunnel are presented for stagnation pressures from 138 N/sq cm to 1655 N/sq cm. The characteristics include detailed Mach number surveys in the test section from which usable core size and regions of disturbed flow were determined, preliminary blockage test results, and maximum run time to be expected at various stagnation pressures. Important tunnel dimensions including details of the model mounting apparatus are given. Measurements show the variation in average core Mach number in the test section to be between 9.4 and 10 for the present range of test conditions. The core radius is from 23 cm to 31.5 cm, depending on stagnation pressure and axial location in the test section.

  7. Noise-free high-efficiency photon-number-resolving detectors

    SciTech Connect

    Rosenberg, Danna; Lita, Adriana E.; Miller, Aaron J.; Nam, Sae Woo

    2005-06-15

    High-efficiency optical detectors that can determine the number of photons in a pulse of monochromatic light have applications in a variety of physics studies, including post-selection-based entanglement protocols for linear optics quantum computing and experiments that simultaneously close the detection and communication loopholes of Bell's inequalities. Here we report on our demonstration of fiber-coupled, noise-free, photon-number-resolving transition-edge sensors with 88% efficiency at 1550 nm. The efficiency of these sensors could be made even higher at any wavelength in the visible and near-infrared spectrum without resulting in a higher dark-count rate or degraded photon-number resolution.

  8. Frontline Science: Splenic progenitors aid in maintaining high neutrophil numbers at sites of sterile chronic inflammation.

    PubMed

    Jhunjhunwala, Siddharth; Alvarez, David; Aresta-DaSilva, Stephanie; Tang, Katherine; Tang, Benjamin C; Greiner, Dale L; Newburger, Peter E; von Andrian, Ulrich H; Langer, Robert; Anderson, Daniel G

    2016-08-01

    Neutrophils are constantly generated from hematopoietic stem and progenitor cells in the bone marrow to maintain high numbers in circulation. A considerable number of neutrophils and their progenitors have been shown to be present in the spleen too; however, their exact role in this organ remains unclear. Herein, we sought to study the function of splenic neutrophils and their progenitors using a mouse model for sterile, peritoneal inflammation. In this microcapsule device implantation model, we show chronic neutrophil presence at implant sites, with recruitment from circulation as the primary mechanism for their prevalence in the peritoneal exudate. Furthermore, we demonstrate that progenitor populations in the spleen play a key role in maintaining elevated neutrophil numbers. Our results provide new insight into the role for splenic neutrophils and their progenitors and establish a model to study neutrophil function during sterile inflammation. PMID:26965635

  9. Measurements of Molecular Mixing in a High Schmidt Number Rayleigh-Taylor Mixing Layer

    SciTech Connect

    Mueschke, N J; Schilling, O; Youngs, D L; Andrews, M

    2007-12-03

    Molecular mixing measurements are performed for a high Schmidt number (Sc {approx} 10{sup 3}), small Atwood number (A {approx} 7.5 x 10{sup -4}) buoyancy-driven turbulent Rayleigh-Taylor mixing layer in a water channel facility. Salt was added to the top stream to create the desired density difference. The degree of molecular mixing was measured as a function of time by monitoring a diffusion-limited chemical reaction between the two fluid streams. The pH of each stream was modified by the addition of acid or alkali such that a local neutralization reaction occurred as the two fluids molecularly mixed. The progress of this neutralization reaction was tracked by the addition of phenolphthalein - a pH-sensitive chemical indicator - to the acidic stream. Accurately calibrated backlit optical techniques were used to measure the average concentration of the colored chemical indicator. Comparisons of chemical product formation for pre-transitional buoyancy- and shear-driven mixing layers are given. It is also shown that experiments performed at different equivalence ratios (acid/alkali concentration) can be combined to obtain a mathematical relationship between the colored product formed and the density variance. This relationship was used to obtain high-fidelity, quantitative measures of the degree of molecular mixing which are independent of probe resolution constraints. The dependence of such mixing parameters on the Schmidt and Reynolds numbers is examined by comparing the current Sc {approx} 10{sup 3} measurements with Sc = 0.7 gas-phase and Pr = 7 liquid-phase measurements. This comparison indicates that the Schmidt number has a large effect on the bulk quantity of mixed fluid at small Reynolds numbers Re{sub h} < 10{sup 3}. At late times, all mixing parameters indicated a greater degree of molecular mixing and a decreased Schmidt number dependence. Implications for the development and quantitative assessment of turbulent transport and mixing models appropriate for

  10. A highly efficient bead extraction technique with low bead number for digital microfluidic immunoassay.

    PubMed

    Huang, Cheng-Yeh; Tsai, Po-Yen; Lee, I-Chin; Hsu, Hsin-Yun; Huang, Hong-Yuan; Fan, Shih-Kang; Yao, Da-Jeng; Liu, Cheng-Hsien; Hsu, Wensyang

    2016-01-01

    Here, we describe a technique to manipulate a low number of beads to achieve high washing efficiency with zero bead loss in the washing process of a digital microfluidic (DMF) immunoassay. Previously, two magnetic bead extraction methods were reported in the DMF platform: (1) single-side electrowetting method and (2) double-side electrowetting method. The first approach could provide high washing efficiency, but it required a large number of beads. The second approach could reduce the required number of beads, but it was inefficient where multiple washes were required. More importantly, bead loss during the washing process was unavoidable in both methods. Here, an improved double-side electrowetting method is proposed for bead extraction by utilizing a series of unequal electrodes. It is shown that, with proper electrode size ratio, only one wash step is required to achieve 98% washing rate without any bead loss at bead number less than 100 in a droplet. It allows using only about 25 magnetic beads in DMF immunoassay to increase the number of captured analytes on each bead effectively. In our human soluble tumor necrosis factor receptor I (sTNF-RI) model immunoassay, the experimental results show that, comparing to our previous results without using the proposed bead extraction technique, the immunoassay with low bead number significantly enhances the fluorescence signal to provide a better limit of detection (3.14 pg/ml) with smaller reagent volumes (200 nl) and shorter analysis time (<1 h). This improved bead extraction technique not only can be used in the DMF immunoassay but also has great potential to be used in any other bead-based DMF systems for different applications. PMID:26858807

  11. NASA High-Reynolds Number Circulation Control Research - Overview of CFD and Planned Experiments

    NASA Technical Reports Server (NTRS)

    Milholen, W. E., II; Jones, Greg S.; Cagle, Christopher M.

    2010-01-01

    A new capability to test active flow control concepts and propulsion simulations at high Reynolds numbers in the National Transonic Facility at the NASA Langley Research Center is being developed. This technique is focused on the use of semi-span models due to their increased model size and relative ease of routing high-pressure air to the model. A new dual flow-path high-pressure air delivery station has been designed, along with a new high performance transonic sem -si pan wing model. The modular wind tunnel model is designed for testing circulation control concepts at both transonic cruise and low-speed high-lift conditions. The ability of the model to test other active flow control techniques will be highlighted. In addition, a new higher capacity semi-span force and moment wind tunnel balance has been completed and calibrated to enable testing at transonic conditions.

  12. How are Strouhal number, drag, and efficiency adjusted in high level underwater monofin-swimming?

    PubMed

    Nicolas, Guillaume; Bideau, Benoit; Colobert, Briac; Berton, Eric

    2007-06-01

    Strouhal number (St) corresponds to a wake parameter based on the tail kinematics of swimming animals according to St=A.f/U, where f is the stroke frequency, A is the fin-beat peak-to-peak amplitude, and U is the forward speed. St number is a trade-off between amplitude and frequency that generates a forward velocity. This parameter may therefore be affected by swimming technique, which can be evaluated through active drag (AD) and Froude efficiency (eta(F)). The aim of our study was therefore to (1) investigate the range of AD and eta(F) values for high level monofin-swimmers, (2) explore the range of St numbers, and (3) examine to what extent this latter non-dimensional parameter may affect AD and eta(F). To this end, experiments have been conducted on 12 international level monofin-swimmers. St number, eta(F) (calculated according to the elongated-body theory), and AD (computed with velocity perturbation method) were calculated at the same time for an underwater fin-swimming trial, at maximal speed. Lowest values of St numbers (St=0.34) corresponded to fin-swimmers with highest velocities (R=-.77, p<.05), highest efficiencies (R=-.86, p<.001), and lowest active drag (R=.91, p<.001). On the one hand, AD was increased with vertical motion of the fin (R=.84, p<.001), which increased cross-sectional area (R=.78, p<.05). On the other hand, efficiencies showed a tendency to peak at eta(F)=0.82 in a narrow range of St numbers close to 0.4. This St range corresponded to the upper limit of the 0.25-0.4 range usually claimed for maximum efficiency of marine and flying animals. Such results suggest that increasing efficiency and reducing drag improves performance per se (regardless how these parameters are related with St number). PMID:17509711

  13. On the instabilities of supersonic mixing layers - A high-Mach-number asymptotic theory

    NASA Technical Reports Server (NTRS)

    Balsa, Thomas F.; Goldstein, M. E.

    1990-01-01

    The stability of a family of tanh mixing layers is studied at large Mach numbers using perturbation methods. It is found that the eigenfunction develops a multilayered structure, and the eigenvalue is obtained by solving a simplified version of the Rayleigh equation (with homogeneous boundary conditions) in one of these layers which lies in either of the external streams. This analysis leads to a simple hypersonic similarity law which explains how spatial and temporal phase speeds and growth rates scale with Mach number and temperature ratio. Comparisons are made with numerical results, and it is found that this similarity law provides a good qualitative guide for the behavior of the instability at high Mach numbers. In addition to this asymptotic theory, some fully numerical results are also presented (with no limitation on the Mach number) in order to explain the origin of the hypersonic modes (through mode splitting) and to discuss the role of oblique modes over a very wide range of Mach number and temperature ratio.

  14. The response of hot wires in high Reynolds-number turbulent pipe flow

    NASA Astrophysics Data System (ADS)

    Li, J. D.; McKeon, B. J.; Jiang, W.; Morrison, J. F.; Smits, A. J.

    2004-05-01

    Issues concerning the accuracy of hot-wire measurements in turbulent pipe flow are addressed for pipe Reynolds numbers up to 6 × 106 and hot-wire Reynolds numbers up to Rew ap 250. These include the optimization of spatial and temporal resolution and the associated feature of signal-to-noise ratio. Very high wire Reynolds numbers enable the use of wires with reduced length-to-diameter ratios compared to those typical of atmospheric conditions owing to increased wire Nusselt numbers. Simulation of the steady-state heat balance for the wire and the unetched portion of wire are used to assess static end-conduction effects: they are used to calculate wire Biot numbers, \\sqrt{c_0}l , and fractional end-conduction losses, sgr, which confirm the 'conduction-only' theory described by Corrsin. They show that, at Rew ap 250, the wire length-to-diameter ratio can be reduced to about 50, while keeping \\sqrt{c_0}l\\gt3 and sgr < 7% in common with accepted limits at Rew ap 3. It is shown that these limits depend additionally on the choice of wire material and the length of unetched wire. The dynamic effects of end-cooling are also assessed using the conduction-only theory.

  15. Nonlocal interactions in hydrodynamic turbulence at high Reynolds numbers: the slow emergence of scaling laws.

    PubMed

    Mininni, P D; Alexakis, A; Pouquet, A

    2008-03-01

    We analyze the data stemming from a forced incompressible hydrodynamic simulation on a grid of 2048(3) regularly spaced points, with a Taylor Reynolds number of R(lambda) ~ 1300. The forcing is given by the Taylor-Green vortex, which shares similarities with the von Kàrmàn flow used in several laboratory experiments; the computation is run for ten turnover times in the turbulent steady state. At this Reynolds number the anisotropic large scale flow pattern, the inertial range, the bottleneck, and the dissipative range are clearly visible, thus providing a good test case for the study of turbulence as it appears in nature. Triadic interactions, the locality of energy fluxes, and longitudinal structure functions of the velocity increments are computed. A comparison with runs at lower Reynolds numbers is performed and shows the emergence of scaling laws for the relative amplitude of local and nonlocal interactions in spectral space. Furthermore, the scaling of the Kolmogorov constant, and of skewness and flatness of velocity increments is consistent with previous experimental results. The accumulation of energy in the small scales associated with the bottleneck seems to occur on a span of wave numbers that is independent of the Reynolds number, possibly ruling out an inertial range explanation for it. Finally, intermittency exponents seem to depart from standard models at high R(lambda), leaving the interpretation of intermittency an open problem. PMID:18517510

  16. Assessment of microcalcifications with limited number of high-precision macrobiopsies.

    PubMed

    Harries, Richard; Lawson, Sarah; Bruckers, Liesbeth

    2010-09-01

    Stereotactic biopsy assessment of microcalcification clusters with direct and frontal macrobiopsies was performed in a population of 46 women screened for breast cancer. The only clinical finding in these women was microcalcification. Sensitivity of the procedure was 98% and calcifications were detected in 107 out of 148 tissue specimens (73%). This is the highest reported ratio so far. Interestingly, the total number of cores was inversely correlated with the success rate, suggesting that the accuracy of the direct and frontal approach is high. Four out of 46 women underwent surgery for malignancy indicating that 41 women escaped intervention with a mean follow-up of at least 1 year. Patient satisfaction is high, in particular regarding reported pain, fear and overall appreciation. No complications were seen. The data suggest that a lower number of macrobiopsies for microcalcifications could be acceptable with direct and frontal biopsy methods without reducing sensitivity. Lowering the number of biopsies can optimize the interpretation of surgical margin and reduce the number of biopsy-related mastectomies. PMID:20495463

  17. The use of small fraction numbers in high dose-rate gynaecological afterloading: some radiobiological considerations.

    PubMed

    Dale, R G

    1990-04-01

    Using commonly assumed alpha/beta ratios for tumours and late-reacting tissues, the linear-quadratic (LQ) model has been used to compare low dose-rate (LDR) gynaecological treatment with high dose-rate (HDR) techniques given in small fraction numbers. Even in the absence of relatively favourable tissue recovery constants (mu values) it is shown that, provided a modest extra amount of geometrical sparing of critical tissues is available (by means of spacing or shielding), HDR treatment in a small number of fractions may be used in place of an LDR regime without loss of therapeutic ratio. This general result, although not universally true, does indicate that HDR treatment delivered in a small number of fractions may be more feasible than is sometimes thought. These findings do not contradict currently accepted radiobiological philosophy, which cautions against the use of small numbers of high-dose fractions. Primarily they serve to emphasize the importance of the recommendations of the ICRU (1985), which stress the need to consider the complete time-dose pattern of radiation delivery to all the critical tissues in an intracavitary treatment. PMID:2346867

  18. On the high Mach number shock structure singularity caused by overreach of Maxwellian molecules

    SciTech Connect

    Myong, R. S.

    2014-05-15

    The high Mach number shock structure singularity arising in moment equations of the Boltzmann equation was investigated. The source of the singularity is shown to be the unbalanced treatment between two high order kinematic and dissipation terms caused by the overreach of Maxwellian molecule assumption. In compressive gaseous flow, the high order stress-strain coupling term of quadratic nature will grow far faster than the strain term, resulting in an imbalance with the linear dissipation term and eventually a blow-up singularity in high thermal nonequilibrium. On the other hand, the singularity arising from unbalanced treatment does not occur in the case of velocity shear and expansion flows, since the high order effects are cancelled under the constraint of the free-molecular asymptotic behavior. As an alternative method to achieve the balanced treatment, Eu's generalized hydrodynamics, consistent with the second law of thermodynamics, was revisited. After introducing the canonical distribution function in exponential form and applying the cumulant expansion to the explicit calculation of the dissipation term, a natural platform suitable for the balanced treatment was derived. The resulting constitutive equation with the nonlinear factor was then shown to be well-posed for all regimes, effectively removing the high Mach number shock structure singularity.

  19. Abnormal Functional Specialization within Medial Prefrontal Cortex in High-Functioning Autism: A Multi-Voxel Similarity Analysis

    ERIC Educational Resources Information Center

    Gilbert, Sam J.; Meuwese, Julia D. I.; Towgood, Karren J.; Frith, Christopher D.; Burgess, Paul W.

    2009-01-01

    Multi-voxel pattern analyses have proved successful in "decoding" mental states from fMRI data, but have not been used to examine brain differences associated with atypical populations. We investigated a group of 16 (14 males) high-functioning participants with autism spectrum disorder (ASD) and 16 non-autistic control participants (12 males)…

  20. Eye movement abnormalities.

    PubMed

    Moncayo, Jorge; Bogousslavsky, Julien

    2012-01-01

    Generation and control of eye movements requires the participation of the cortex, basal ganglia, cerebellum and brainstem. The signals of this complex neural network finally converge on the ocular motoneurons of the brainstem. Infarct or hemorrhage at any level of the oculomotor system (though more frequent in the brain-stem) may give rise to a broad spectrum of eye movement abnormalities (EMAs). Consequently, neurologists and particularly stroke neurologists are routinely confronted with EMAs, some of which may be overlooked in the acute stroke setting and others that, when recognized, may have a high localizing value. The most complex EMAs are due to midbrain stroke. Horizontal gaze disorders, some of them manifesting unusual patterns, may occur in pontine stroke. Distinct varieties of nystagmus occur in cerebellar and medullary stroke. This review summarizes the most representative EMAs from the supratentorial level to the brainstem. PMID:22377853

  1. On the Design of Lifting Airfoils with High Critical Mach Number Using Full Potential Theory

    NASA Astrophysics Data System (ADS)

    Kropinski, M. C. A.

    We wish to construct airfoils that have the highest free-stream Mach number for a given set of geometric constraints for which the flow is nowhere supersonic. Nonlifting airfoils that maximize the critical Mach number for a given cross-sectional area are known to possess long sonic segments at their critical speed. To construct lifting airfoils, we proceed under the conjecture that an airfoil with a high value of has the longest possible arc length of sonic velocity over its upper and lower surface. In Kropinski etal. (1995) the lifting problem was tackled in transonic small-disturbance theory. In this paper we numerically construct lifting airfoils with high using the full potential theory and we show that these airfoils have significantly higher than some standard airfoils. We also construct airfoils with higher values of the lift coefficient, by relaxing the speed constraint on the lower surface of the airfoil to have a value less than sonic.

  2. A multilocus variable number tandem repeat analysis assay provides high discrimination for genotyping Leptospira santarosai strains

    PubMed Central

    Hamond, Camila; Pinna, Melissa; Medeiros, Marco Alberto; Bourhy, Pascale; Lilenbaum, Walter

    2015-01-01

    Considering the prevalence of Leptospira santarosai infections in the Americas and the scarce information about the species, we aimed to apply a multilocus variable number tandem repeat (VNTR) analysis (MLVA) for the molecular typing of L. santarosai isolates from various sources. Amplification of three VNTR loci selected from L. santarosai genome sequences resulted in a wide range of sizes for the amplified products amongst the 21 L. santarosai strains analysed. This suggested a variation in tandem repeat copy numbers in the VNTR loci. secY sequencing also showed a high nucleotide diversity, confirming the MLVA data. In conclusion, this novel MLVA provided a high level of discrimination between L. santarosai isolates, and this new typing tool could be used to investigate leptospirosis in regions where L. santarosai predominates. PMID:25721051

  3. A third-order-accurate upwind scheme for Navier-Stokes solutions at high Reynolds numbers

    NASA Astrophysics Data System (ADS)

    Agarwal, R. K.

    1981-01-01

    A third-order-accurate upwind scheme is presented for solution of the steady two-dimensional Navier-Stokes equations in stream-function/vorticity form. The scheme is found to be accurate and stable at high Reynolds numbers. A series of test computations is performed on flows with large recirculating regions. In particular, highly accurate solutions are obtained for flow in a driven square cavity up to Reynolds numbers of 10,000. These computations are used to critically evaluate the accuracy of other existing first- and second-order-accurate upwind schemes. In addition, computations are carried out for flow in a channel with symmetric sudden expansion, flow in a channel with a symmetrically placed blunt base, and the flowfield of an impinging jet. Good agreement is obtained with the computations of other investigators as well as with the available experimental data.

  4. Detached eddy simulation of high-Reynolds-number turbulent flows using the immersed boundary method

    NASA Astrophysics Data System (ADS)

    Bernardini, Matteo; Pirozzoli, Sergio; Orlandi, Paolo

    2015-11-01

    Detached Eddy Simulation based on the Spalart-Allmaras turbulence model is applied in conjunction with the immersed boundary method to simulate high-Reynolds number turbulent flows in complex geometries. A fourth-order, finite-difference solver capable of discretely preserving the kinetic energy in the limit of inviscid flow is adopted to solve the compressible Navier-Stokes equations and model-consistent, adaptive wall functions are employed to provide the proper numerical boundary conditions at the fluid/solid interface. Numerical tests, performed for several configurations involving massively separated flows, demonstrate that computations at high-Reynolds number, as typically occurring in flows of industrial relevance, can be successfully carried out using the immersed boundary strategy, providing predictions whose accuracy is comparable to that of standard, body-fitted, structured or unstructured flow solvers.

  5. NEW FRONTIER IN UNDERSTANDING THE MECHANISMS OF DEVELOPMENTAL ABNORMALITIES

    EPA Science Inventory

    Recent advancements in molecular developmental biology afford an opportunity to apply newly developed tools for understanding the mechanisms of both normal and abnormal development. lthough a number of agents have been identified as causing developmental abnormalities, knowledge ...

  6. PUFKEY: a high-security and high-throughput hardware true random number generator for sensor networks.

    PubMed

    Li, Dongfang; Lu, Zhaojun; Zou, Xuecheng; Liu, Zhenglin

    2015-01-01

    Random number generators (RNG) play an important role in many sensor network systems and applications, such as those requiring secure and robust communications. In this paper, we develop a high-security and high-throughput hardware true random number generator, called PUFKEY, which consists of two kinds of physical unclonable function (PUF) elements. Combined with a conditioning algorithm, true random seeds are extracted from the noise on the start-up pattern of SRAM memories. These true random seeds contain full entropy. Then, the true random seeds are used as the input for a non-deterministic hardware RNG to generate a stream of true random bits with a throughput as high as 803 Mbps. The experimental results show that the bitstream generated by the proposed PUFKEY can pass all standard national institute of standards and technology (NIST) randomness tests and is resilient to a wide range of security attacks. PMID:26501283

  7. PUFKEY: A High-Security and High-Throughput Hardware True Random Number Generator for Sensor Networks

    PubMed Central

    Li, Dongfang; Lu, Zhaojun; Zou, Xuecheng; Liu, Zhenglin

    2015-01-01

    Random number generators (RNG) play an important role in many sensor network systems and applications, such as those requiring secure and robust communications. In this paper, we develop a high-security and high-throughput hardware true random number generator, called PUFKEY, which consists of two kinds of physical unclonable function (PUF) elements. Combined with a conditioning algorithm, true random seeds are extracted from the noise on the start-up pattern of SRAM memories. These true random seeds contain full entropy. Then, the true random seeds are used as the input for a non-deterministic hardware RNG to generate a stream of true random bits with a throughput as high as 803 Mbps. The experimental results show that the bitstream generated by the proposed PUFKEY can pass all standard national institute of standards and technology (NIST) randomness tests and is resilient to a wide range of security attacks. PMID:26501283

  8. Prevalence of High-Risk Human Papillomavirus (HR-HPV) Genotypes and Multiple Infections in Cervical Abnormalities from Northern Xinjiang, China

    PubMed Central

    Du, Jingyun; Jiang, Jianjun; Jia, Xuesong; Chen, Chuangfu; Wang, Yuanzhi

    2016-01-01

    Multiple human papillomavirus (HPV) genotypes often coexist within the cervical epithelia and are frequently detected together in various grades of the cervical neoplasia. To date, only a few reports exist on multiple HPV infections of HPV in Xinjiang Uygur Autonomous Region (XUAR). In the present study, we investigated the prevalence of High-Risk HPV (HR-HPV) genotypes and multiple infections. Cervical cytology samples were collected from 428 women who presented cervical abnormalities. Genotyping of HPV was performed by polymerase chain reaction–sequencing based typing (PCR-SBT) using consensus primers and specific primers. Of them, 166 samples were positive for HPV according to PCR results using the consensus primers. These samples contained cervical abnormalities enriched with inflammation (n = 107), cervical intraepithelial neoplasia (CIN) I (n = 19), CINII-III (n = 9) and cervical cancer (n = 31). Of the 166 HPV positive samples as determined by PCR analysis, 151 were further typed by PCR-SBT using 19 pairs of genotype-specific primers. Using this method, 17 different HR-HPV genotypes were identified. The most frequently observed HPV genotypes were HPV16 (44.0%, 73/166), 53 (28.9%, 48/166), 52 (25.3%, 42/166), 58 (22.3%, 37/166) and 35 (17.5%, 29/166). The proportions of single and multiple infections in the HPV-positive specimens were 34.9% and 65.1%, respectively. Multiple HPV types were most prevalent in the inflammatory state (63.0%), followed by cervical cancer (24.1%), CINI (11.1%), and CINII-III (1.9%). The results of our data analyses suggested that i) multiple HPV infection is not necessarily correlated with the severity of cervical abnormalities; and ii) among the multiple HPV infections, double infections combined with HPV16 is the most common. In addition, L1 full-length sequences of the top five high-risk HPV genotypes were amplified and sequenced. According to the L1 sequence of the epidemic genotypes that were amplified, we found that these

  9. Electron heating in a Monte Carlo model of a high Mach number, supercritical, collisionless shock

    NASA Technical Reports Server (NTRS)

    Ellison, Donald C.; Jones, Frank C.

    1987-01-01

    Preliminary work in the investigation of electron injection and acceleration at parallel shocks is presented. A simple model of electron heating that is derived from a unified shock model which includes the effects of an electrostatic potential jump is described. The unified shock model provides a kinetic description of the injection and acceleration of ions and a fluid description of electron heating at high Mach number, supercritical, and parallel shocks.

  10. Simulation of transient flow in a shock tunnel and a high Mach number nozzle

    NASA Technical Reports Server (NTRS)

    Jacobs, P. A.

    1991-01-01

    A finite volume Navier-Stokes code was used to simulate the shock reflection and nozzle starting processes in an axisymmetric shock tube and a high Mach number nozzle. The simulated nozzle starting processes were found to match the classical quasi-1-D theory and some features of the experimental measurements. The shock reflection simulation illustrated a new mechanism for the driver gas contamination of the stagnated test gas.

  11. A highly abnormal massive star mass function in the Orion Nebula cluster and the dynamical decay of trapezium systems

    NASA Astrophysics Data System (ADS)

    Pflamm-Altenburg, J.; Kroupa, P.

    2006-11-01

    The Orion Nebula cluster (ONC) appears to be unusual on two grounds: the observed constellation of the OB stars of the entire ONC and its Trapezium at its centre implies a time-scale problem given the age of the Trapezium, and an initial mass function (IMF) problem for the whole OB star population in the ONC. Given the estimated crossing time of the Trapezium, it ought to have totally dynamically decayed by now. Furthermore, by combining the lower limit of the ONC mass with a standard IMF it emerges that the ONC should have formed at least about 40 stars heavier than 5 Msolar while only 10 are observed. Using the N-body experiments we (i) confirm the expected instability of the Trapezium and (ii) show that beginning with a compact OB-star configuration of about 40 stars both the number of observed OB stars after 1 Myr within 1 pc radius and a compact trapezium configuration can be reproduced. These two empirical constraints thus support our estimate of 40 initial OB stars in the cluster. Interestingly, a more-evolved version of the ONC resembles the Upper Scorpius OB association. The N-body experiments are performed with the new C-code CATENA by integrating the equations of motion using the chain-multiple-regularization method. In addition, we present a new numerical formulation of the IMF.

  12. Vescalagin from Pink Wax Apple [Syzygium samarangense (Blume) Merrill and Perry] Alleviates Hepatic Insulin Resistance and Ameliorates Glycemic Metabolism Abnormality in Rats Fed a High-Fructose Diet.

    PubMed

    Huang, Da-Wei; Chang, Wen-Chang; Wu, James Swi-Bea; Shih, Rui-Wen; Shen, Szu-Chuan

    2016-02-10

    This study investigates the ameliorative effect of vescalagin (VES) isolated from Pink wax apple fruit on hepatic insulin resistance and abnormal carbohydrate metabolism in high-fructose diet (HFD)-induced hyperglycemic rats. The results show that in HFD rats, VES significantly reduced the values of the area under the curve for glucose in an oral glucose tolerance test and the homeostasis model assessment of insulin resistance index. VES significantly enhanced the activity of hepatic antioxidant enzymes while reducing thiobarbituric acid-reactive substances in HFD rats. Western blot assay revealed that VES reduced hepatic protein expression involved in inflammation pathways while up-regulating expression of hepatic insulin signaling-related proteins. Moreover, VES up-regulated the expression of hepatic glycogen synthase and hepatic glycolysis-related proteins while down-regulating hepatic gluconeogenesis-related proteins in HFD rats. This study suggests some therapeutic potential of VES in preventing the progression of diabetes mellitus. PMID:26800576

  13. Heat transfer for falling film evaporation of industrially relevant fluids up to very high Prandtl numbers

    NASA Astrophysics Data System (ADS)

    Gourdon, Mathias; Karlsson, Erik; Innings, Fredrik; Jongsma, Alfred; Vamling, Lennart

    2016-02-01

    In many industrial applications, falling film evaporation is an attractive technique for solvent removal due to high heat transfer and low residence times. Examples are the powder production in the dairy industry and in kraft pulp production process to remove water from so called black liquor. Common for both applications is that the fluids exhibit high viscosities in industrial practice. In this paper, results from experimental studies on both black liquor and a dairy product are reported for Prandtl numbers up to 800. The results are compared with several existing correlation in literature, and the need for a modified correlation is recognized especially to cover higher Prandtl-numbers. The following correlation for the turbulent flow region with 3 < Pr < 800 was derived from the data: {Nu}t = 0.0085 \\cdot Re^{0.2} \\cdot {Pr^{0.65}} The correlation has been compared to literature data from one additional study on two other fluids (propylene glycol and cyclohexanol) with fairly high Prandtl-numbers, from 40 to 58 and from 45 to 155 respectively and the agreement was within ±40 %.

  14. Evaluation of Computational Method of High Reynolds Number Slurry Flow for Caverns Backfilling

    SciTech Connect

    Bettin, Giorgia

    2015-05-01

    The abandonment of salt caverns used for brining or product storage poses a significant environmental and economic risk. Risk mitigation can in part be address ed by the process of backfilling which can improve the cavern geomechanical stability and reduce the risk o f fluid loss to the environment. This study evaluate s a currently available computational tool , Barracuda, to simulate such process es as slurry flow at high Reynolds number with high particle loading . Using Barracuda software, a parametric sequence of simu lations evaluated slurry flow at Re ynolds number up to 15000 and loading up to 25%. Li mitations come into the long time required to run these simulation s due in particular to the mesh size requirement at the jet nozzle. This study has found that slurry - jet width and centerline velocities are functions of Re ynold s number and volume fractio n The solid phase was found to spread less than the water - phase with a spreading rate smaller than 1 , dependent on the volume fraction. Particle size distribution does seem to have a large influence on the jet flow development. This study constitutes a first step to understand the behavior of highly loaded slurries and their ultimate application to cavern backfilling.

  15. Tooth - abnormal shape

    MedlinePlus

    Hutchinson incisors; Abnormal tooth shape; Peg teeth; Mulberry teeth; Conical teeth ... The appearance of normal teeth varies, especially the molars. ... conditions. Specific diseases can affect tooth shape, tooth ...

  16. Tooth - abnormal shape

    MedlinePlus

    Hutchinson incisors; Abnormal tooth shape; Peg teeth; Mulberry teeth; Conical teeth ... from many different conditions. Specific diseases can affect tooth shape, tooth color, time of appearance, or absence ...

  17. Spontaneous occurrence of chromosome abnormality in cats.

    PubMed

    THULINE, H C; NORBY, D W

    1961-08-25

    A syndrome in male cats analogous to chromatin-positive Klinefelter's syndrome in human males has been demonstrated. The physical characteristics which suggested an abnormality of chromosome number in cats were "calico" or "tortoise-shell" coat colors in a male. Buccal mucosal smears were found to have "female-type" patterns in two out of 12 such male cats screened, and these two were found to have a diploid chromosome number of 39 rather than the normal 38. Testicular biopsy performed on one revealed an abnormal pattern; no gonadal tissue was found in the other cat with an abnormal chromosome number. These findings indicate that the cat, in addition to the mouse, is available for experimental study of chromosome number abnormalities. PMID:13776765

  18. Unstructured and adaptive mesh generation for high Reynolds number viscous flows

    NASA Technical Reports Server (NTRS)

    Mavriplis, Dimitri J.

    1991-01-01

    A method for generating and adaptively refining a highly stretched unstructured mesh suitable for the computation of high-Reynolds-number viscous flows about arbitrary two-dimensional geometries was developed. The method is based on the Delaunay triangulation of a predetermined set of points and employs a local mapping in order to achieve the high stretching rates required in the boundary-layer and wake regions. The initial mesh-point distribution is determined in a geometry-adaptive manner which clusters points in regions of high curvature and sharp corners. Adaptive mesh refinement is achieved by adding new points in regions of large flow gradients, and locally retriangulating; thus, obviating the need for global mesh regeneration. Initial and adapted meshes about complex multi-element airfoil geometries are shown and compressible flow solutions are computed on these meshes.

  19. Sweep and Compressibility Effects on Active Separation Control at High Reynolds Numbers

    NASA Technical Reports Server (NTRS)

    Seifert, Avi; Pack, LaTunia G.

    2000-01-01

    This paper explores the effects of compressibility, sweep and excitation location on active separation control at high Reynolds numbers. The model, which was tested in a cryogenic pressurized wind tunnel, simulates the upper surface of a 20% thick Glauert Goldschmied type airfoil at zero angle of attack. The flow is fully turbulent since the tunnel sidewall boundary layer flows over the model. Without control, the flow separates at the highly convex area and a large turbulent separation bubble is formed. Periodic excitation is applied to gradually eliminate the separation bubble. Two alternative blowing slot locations as well as the effect of compressibility, sweep and steady suction or blowing were studied. During the test the Reynolds numbers ranged from 2 to 40 million and Mach numbers ranged from 0.2 to 0.7. Sweep angles were 0 and 30 deg. It was found that excitation must be introduced slightly upstream of the separation region regardless of the sweep angle at low Mach number. Introduction of excitation upstream of the shock wave is more effective than at its foot. Compressibility reduces the ability of steady mass transfer and periodic excitation to control the separation bubble but excitation has an effect on the integral parameters, which is similar to that observed in low Mach numbers. The conventional swept flow scaling is valid for fully and even partially attached flow, but different scaling is required for the separated 3D flow. The effectiveness of the active control is not reduced by sweep. Detailed flow field dynamics are described in the accompanying paper.

  20. Breathing abnormalities in sleep in achondroplasia.

    PubMed Central

    Waters, K A; Everett, F; Sillence, D; Fagan, E; Sullivan, C E

    1993-01-01

    Overnight sleep studies were performed in 20 subjects with achondroplasia to document further the respiratory abnormalities present in this group. Somatosensory evoked potentials (SEPs) were recorded in 19 of the subjects to screen for the presence of brainstem abnormalities, which are one of the potential aetiological mechanisms. Fifteen children aged 1 to 14 years, and five young adults, aged 20 to 31 years were included. All had upper airway obstruction and 15 (75%) had a pathological apnoea index (greater than five per hour). Other sleep associated respiratory abnormalities, including partial obstruction, central apnoea, and abnormal electromyographic activity of accessory muscles of respiration, also showed a high prevalence. SEPs were abnormal in eight (42%), but there was no correlation between abnormal SEPs and apnoea during sleep, either qualitatively or quantitatively. A high prevalence of both sleep related respiratory abnormalities and abnormal SEPs in young subjects with achondroplasia was demonstrated. However, the sleep related respiratory abnormalities do not always result in significant blood gas disturbances or correlate with abnormal SEPs in this group. PMID:8215519

  1. Neuroanatomic and cognitive abnormalities in attention-deficit/hyperactivity disorder in the era of 'high definition' neuroimaging.

    PubMed

    Baroni, Argelinda; Castellanos, F Xavier

    2015-02-01

    The ongoing release of the Human Connectome Project (HCP) data is a watershed event in clinical neuroscience. By attaining a quantum leap in spatial and temporal resolution within the framework of a twin/sibling design, this open science resource provides the basis for delineating brain-behavior relationships across the neuropsychiatric landscape. Here we focus on attention-deficit/hyperactivity disorder (ADHD), which is at least partly continuous across the population, highlighting constructs that have been proposed for ADHD and which are included in the HCP phenotypic battery. We review constructs implicated in ADHD (reward-related processing, inhibition, vigilant attention, reaction time variability, timing and emotional lability) which can be examined in the HCP data and in future 'high definition' clinical datasets. PMID:25212469

  2. Neuroanatomic and Cognitive Abnormalities in Attention-Deficit/Hyperactivity Disorder in the Era of “High Definition” Neuroimaging

    PubMed Central

    Baroni, Argelinda; Castellanos, F. Xavier

    2014-01-01

    The ongoing release of the Human Connectome Project (HCP) data is a watershed event in clinical neuroscience. By attaining a quantum leap in spatial and temporal resolution within the framework of a twin/sibling design, this open science resource provides the basis for delineating brain-behavior relationships across the neuropsychiatric landscape. Here we focus on attention-deficit/hyperactivity disorder (ADHD), which is at least partly continuous across the population, highlighting constructs that have been proposed for ADHD and which are included in the HCP phenotypic battery. We review constructs implicated in ADHD (reward-related processing, inhibition, vigilant attention, reaction time variability, timing and emotional lability) which can be examined in the HCP data and in future “high definition” clinical datasets. PMID:25212469

  3. Abnormally High Content of Free Glucosamine Residues Identified in a Preparation of Commercially Available Porcine Intestinal Heparan Sulfate.

    PubMed

    Mulloy, Barbara; Wu, Nian; Gyapon-Quast, Frederick; Lin, Lei; Zhang, Fuming; Pickering, Matthew C; Linhardt, Robert J; Feizi, Ten; Chai, Wengang

    2016-07-01

    Heparan sulfate (HS) polysaccharides are ubiquitous in animal tissues as components of proteoglycans, and they participate in many important biological processes. HS carbohydrate chains are complex and can contain rare structural components such as N-unsubstituted glucosamine (GlcN). Commercially available HS preparations have been invaluable in many types of research activities. In the course of preparing microarrays to include probes derived from HS oligosaccharides, we found an unusually high content of GlcN residue in a recently purchased batch of porcine intestinal mucosal HS. Composition and sequence analysis by mass spectrometry of the oligosaccharides obtained after heparin lyase III digestion of the polysaccharide indicated two and three GlcN in the tetrasaccharide and hexasaccharide fractions, respectively. (1)H NMR of the intact polysaccharide showed that this unusual batch differed strikingly from other HS preparations obtained from bovine kidney and porcine intestine. The very high content of GlcN (30%) and low content of GlcNAc (4.2%) determined by disaccharide composition analysis indicated that N-deacetylation and/or N-desulfation may have taken place. HS is widely used by the scientific community to investigate HS structures and activities. Great care has to be taken in drawing conclusions from investigations of structural features of HS and specificities of HS interaction with proteins when commercial HS is used without further analysis. Pending the availability of a validated commercial HS reference preparation, our data may be useful to members of the scientific community who have used the present preparation in their studies. PMID:27295282

  4. Abnormally High Content of Free Glucosamine Residues Identified in a Preparation of Commercially Available Porcine Intestinal Heparan Sulfate

    PubMed Central

    2016-01-01

    Heparan sulfate (HS) polysaccharides are ubiquitous in animal tissues as components of proteoglycans, and they participate in many important biological processes. HS carbohydrate chains are complex and can contain rare structural components such as N-unsubstituted glucosamine (GlcN). Commercially available HS preparations have been invaluable in many types of research activities. In the course of preparing microarrays to include probes derived from HS oligosaccharides, we found an unusually high content of GlcN residue in a recently purchased batch of porcine intestinal mucosal HS. Composition and sequence analysis by mass spectrometry of the oligosaccharides obtained after heparin lyase III digestion of the polysaccharide indicated two and three GlcN in the tetrasaccharide and hexasaccharide fractions, respectively. 1H NMR of the intact polysaccharide showed that this unusual batch differed strikingly from other HS preparations obtained from bovine kidney and porcine intestine. The very high content of GlcN (30%) and low content of GlcNAc (4.2%) determined by disaccharide composition analysis indicated that N-deacetylation and/or N-desulfation may have taken place. HS is widely used by the scientific community to investigate HS structures and activities. Great care has to be taken in drawing conclusions from investigations of structural features of HS and specificities of HS interaction with proteins when commercial HS is used without further analysis. Pending the availability of a validated commercial HS reference preparation, our data may be useful to members of the scientific community who have used the present preparation in their studies. PMID:27295282

  5. Time dependent heat transfer rates in high Reynolds number hypersonic flowfields

    NASA Technical Reports Server (NTRS)

    Flanagan, Michael J.

    1992-01-01

    Time dependent heat transfer rates have been calculated from time dependent temperature measurements in the vicinity of shock-wave boundary-layer interactions due to conical compression ramps on an axisymmetric body. The basic model is a cylindrical body with a 10 degree conical nose. Four conical ramps, 20, 25, 30, and 35 degrees serve as shock wave generators. Flowfield surveys have been made in the vicinity of the conical ramp vertex, the separation point, and the reattachment point. A significant effort was made to characterize the natural frequencies and relative powers of the resulting fluctuations in heat transfer rates. This research effort, sponsored jointly by NASA and the Air Force, was conducted in the Air Force Flight Dynamics Directorate High Reynolds Facility. The nominal freestream Mach number was 6, and the freestream Reynolds numbers ranged from 2.2 million/ft to 30.0 million/ft. Experimental results quantify temperature response and the resulting heat transfer rates as a function of ramp angle and Reynolds number. The temperature response within the flowfield appears to be steady-state for all compression ramp angles and all Reynolds numbers, and hence, the heat transfer rates appear to be steady-state.

  6. Accurate and reliable high-throughput detection of copy number variation in the human genome

    PubMed Central

    Fiegler, Heike; Redon, Richard; Andrews, Dan; Scott, Carol; Andrews, Robert; Carder, Carol; Clark, Richard; Dovey, Oliver; Ellis, Peter; Feuk, Lars; French, Lisa; Hunt, Paul; Kalaitzopoulos, Dimitrios; Larkin, James; Montgomery, Lyndal; Perry, George H.; Plumb, Bob W.; Porter, Keith; Rigby, Rachel E.; Rigler, Diane; Valsesia, Armand; Langford, Cordelia; Humphray, Sean J.; Scherer, Stephen W.; Lee, Charles; Hurles, Matthew E.; Carter, Nigel P.

    2006-01-01

    This study describes a new tool for accurate and reliable high-throughput detection of copy number variation in the human genome. We have constructed a large-insert clone DNA microarray covering the entire human genome in tiling path resolution that we have used to identify copy number variation in human populations. Crucial to this study has been the development of a robust array platform and analytic process for the automated identification of copy number variants (CNVs). The array consists of 26,574 clones covering 93.7% of euchromatic regions. Clones were selected primarily from the published “Golden Path,” and mapping was confirmed by fingerprinting and BAC-end sequencing. Array performance was extensively tested by a series of validation assays. These included determining the hybridization characteristics of each individual clone on the array by chromosome-specific add-in experiments. Estimation of data reproducibility and false-positive/negative rates was carried out using self–self hybridizations, replicate experiments, and independent validations of CNVs. Based on these studies, we developed a variance-based automatic copy number detection analysis process (CNVfinder) and have demonstrated its robustness by comparison with the SW-ARRAY method. PMID:17122085

  7. Reduced numbers of switched memory B cells with high terminal differentiation potential in Down syndrome

    PubMed Central

    Carsetti, Rita; Valentini, Diletta; Marcellini, Valentina; Scarsella, Marco; Marasco, Emiliano; Giustini, Ferruccio; Bartuli, Andrea; Villani, Alberto; Ugazio, Alberto G

    2015-01-01

    Children with Down syndrome (DS) have increased susceptibility to infections and a high frequency of leukemia and autoimmune disorders, suggesting that immunodeficiency and immune dysfunction are integral parts of the syndrome. A reduction in B-cell numbers has been reported, associated with moderate immunodeficiency and normal immunoglobulin levels. Here, we compared B-cell populations of 19 children with DS with those in healthy age-matched controls. We found that all steps of peripheral B-cell development are altered in DS, with a more severe defect during the later stages of B-cell development. Transitional and mature-naïve B-cell numbers are reduced by 50% whereas switched memory B cells represent 10–15% of the numbers in age-matched controls. Serum IgM levels were slightly reduced, but all other immunoglobulin isotypes were in the normal range. The frequency of switched memory B cells specific for vaccine antigens was significantly lower in affected children than in their equivalently vaccinated siblings. In vitro switched memory B cells of patients with DS have an increased ability to differentiate into antibody-forming cells in response to TLR9 signals. Tailored vaccination schedules increasing the number of switched memory B cells may improve protection and reduce the risk of death from infection in DS. PMID:25472482

  8. High-Reynolds Number Circulation Control Testing in the National Transonic Facility

    NASA Technical Reports Server (NTRS)

    Milholen, William E., II; Jones, Gregory S.; Chan, David T.; Goodliff, Scott L.

    2012-01-01

    A new capability to test active flow control concepts and propulsion simulations at high Reynolds numbers in the National Transonic Facility at the NASA Langley Research Center is being developed. The first active flow control experiment was completed using the new FAST-MAC semi-span model to study Reynolds number scaling effects for several circulation control concepts. Testing was conducted over a wide range of Mach numbers, up to chord Reynolds numbers of 30 million. The model was equipped with four onboard flow control valves allowing independent control of the circulation control plenums, which were directed over a 15% chord simple-hinged flap. Preliminary analysis of the uncorrected lift data showed that the circulation control increased the low-speed maximum lift coefficient by 33%. At transonic speeds, the circulation control was capable of positively altering the shockwave pattern on the upper wing surface and reducing flow separation. Furthermore, application of the technique to only the outboard portion of the wing demonstrated the feasibility of a pneumatic based roll control capability.

  9. A study of high-lift airfoils at high Reynolds numbers in the Langley low-turbulence pressure tunnel

    NASA Technical Reports Server (NTRS)

    Morgan, Harry L., Jr.; Ferris, James C.; Mcghee, Robert J.

    1987-01-01

    An experimental study was conducted in the Langley Low Turbulence Pressure Tunnel to determine the effects of Reynolds number and Mach number on the two-dimensional aerodynamic performance of two supercritical type airfoils, one equipped with a conventional flap system and the other with an advanced high lift flap system. The conventional flap system consisted of a leading edge slat and a double slotted, trailing edge flap with a small chord vane and a large chord aft flap. The advanced flap system consisted of a leading edge slat and a double slotted, trailing edge flap with a large chord vane and a small chord aft flap. Both models were tested with all elements nested to form the cruise airfoil and with the leading edge slat and with a single or double slotted, trailing edge flap deflected to form the high lift airfoils. The experimental tests were conducted through a Reynolds number range from 2.8 to 20.9 x 1,000,000 and a Mach number range from 0.10 to 0.35. Lift and pitching moment data were obtained. Summaries of the test results obtained are presented and comparisons are made between the observed aerodynamic performance trends for both models. The results showing the effect of leading edge frost and glaze ice formation is given.

  10. Fast response temperature and humidity sensors for measurements in high Reynolds number flows

    NASA Astrophysics Data System (ADS)

    Fan, Yuyang; Arwatz, Gilad; Vallikivi, Margit; Hultmark, Marcus

    2013-11-01

    Conventional hot/cold wires have been widely used in measuring velocity and temperature in turbulent flows due to their fine resolutions and fast response. However, for very high Reynolds number flows, limitations on the resolution appear. A very high Reynolds number flow is the atmospheric boundary layer. In order to accurately predict the energy balance at the Earth's surface, one needs information about the different turbulent scalar fields, mainly temperature and humidity, which together with velocity, contribute to the turbulent fluxes away from the surface. The nano-scaled thermal anemometry probe (NSTAP) was previously developed at Princeton and has proven to have much higher spatial and temporal resolution than the regular hot wires. Here we introduce new fast-response temperature and humidity sensors that have been developed and tested. These sensors are made in-house using standard MEMS manufacturing techniques, leaving high flexibility in the process for optimization to different conditions. The small dimensions of these novel sensors enable very high spatial resolution while the small thermal mass allows significant improvements in the frequency response. These sensors have shown promising results in acquiring un-biased data of turbulent scalar and vector fields. Supported under ONR Grants N00014-12-1-0875 and N00014-12-1-0962 (program manager Ki-Han Kim).

  11. Universality of spectrum of passive scalar variance at very high Schmidt number in isotropic steady turbulence

    NASA Astrophysics Data System (ADS)

    Gotoh, Toshiyuki

    2012-11-01

    Spectrum of passive scalar variance at very high Schmidt number up to 1000 in isotropic steady turbulence has been studied by using very high resolution DNS. Gaussian random force and scalar source which are isotropic and white in time are applied at low wavenumber band. Since the Schmidt number is very large, the system was integrated for 72 large eddy turn over time for the system to forgot the initial state. It is found that the scalar spectrum attains the asymptotic k-1 spectrum in the viscous-convective range and the constant CB is found to be 5.7 which is larger than 4.9 obtained by DNS under the uniform mean scalar gradient. Reasons for the difference are inferred as the Reynolds number effect, anisotropy, difference in the scalar injection, duration of time average, and the universality of the constant is discussed. The constant CB is also compared with the prediction by the Lagrangian statistical theory for the passive scalar. The scalar spectrum in the far diffusive range is found to be exponential, which is consistent with the Kraichnan's spectrum. However, the Kraichnan spectrum was derived under the assumption that the velocity field is white in time, therefore theoretical explanation of the agreement needs to be explored. Grant-in-Aid for Scientific Research No. 21360082, Ministry of Education, Culture, Sports, Science and Technology of Japan.

  12. Brain abnormalities in high-risk violent offenders and their association with psychopathic traits and criminal recidivism.

    PubMed

    Leutgeb, V; Leitner, M; Wabnegger, A; Klug, D; Scharmüller, W; Zussner, T; Schienle, A

    2015-11-12

    Measures of psychopathy have been proved to be valuable for risk assessment in violent criminals. However, the neuronal basis of psychopathy and its contribution to the prediction of criminal recidivism is still poorly understood. We compared structural imaging data from 40 male high-risk violent offenders and 37 non-delinquent healthy controls via voxel-based morphometry. Psychopathic traits and risk of violence recidivism were correlated with gray matter volume (GMV) of regions of interest previously shown relevant for criminal behavior. Relative to controls, criminals showed less GMV in the prefrontal cortex (PFC) and more GMV in cerebellar regions and basal ganglia structures. Within criminals, we found a negative correlation between prefrontal GMV and psychopathy. Additionally, there was a positive correlation between cerebellar GMV and psychopathy as well as risk of recidivism for violence. Moreover, GMVs of the basal ganglia and supplementary motor area (SMA) were positively correlated with anti-sociality. GMV of the amygdala was negatively correlated with dynamic risk for violence recidivism. In contrast, GMV of (para)limbic areas (orbitofrontal cortex, insula) was positively correlated with anti-sociality and risk of violence recidivism. The current investigation revealed that in violent offenders deviations in GMV of the PFC as well as areas involved in the motor component of impulse control (cerebellum, basal ganglia, SMA) are differentially related to psychopathic traits and the risk of violence recidivism. The results might be valuable for improving existing risk assessment tools. PMID:26362887

  13. Abnormalities in myo-inositol metabolism associated with type 2 diabetes in mice fed a high-fat diet: benefits of a dietary myo-inositol supplementation.

    PubMed

    Croze, Marine L; Géloën, Alain; Soulage, Christophe O

    2015-06-28

    We previously reported that a chronic supplementation with myo-inositol (MI) improved insulin sensitivity and reduced fat accretion in mice. We then tested the potency of such dietary intervention in the prevention of insulin resistance in C57BL/6 male mouse fed a high-fat diet (HFD). In addition, some abnormalities in inositol metabolism were reported to be associated with insulin resistance in several animal and human studies. We then investigated the presence of such anomalies (i.e. inosituria and an inositol intra-tissue depletion) in this diet-induced obesity (DIO) mouse model, as well as the potential benefit of a MI supplementation for inositol intra-tissue deficiency correction. HFD (60 % energy from fat) feeding was associated with inosituria and inositol intra-tissue depletion in the liver and kidneys. MI supplementation (0·58 mg/g per d) restored inositol pools in kidneys (partially) and liver (fully). HFD feeding for 4 months induced ectopic lipid redistribution to liver and muscles, fasting hyperglycaemia and hyperinsulinaemia, insulin resistance and obesity that were not prevented by MI supplementation, despite a significant improvement in insulin sensitivity parameter K insulin tolerance test and a reduction in white adipose tissue (WAT) mass ( - 17 %, P< 0·05). MI supplementation significantly reduced fatty acid synthase activity in epididymal WAT, which might explain its beneficial, but modest, effect on WAT accretion in HFD-fed mice. Finally, we found some abnormalities in inositol metabolism in association with a diabetic phenotype (i.e. insulin resistance and fasting hyperglycaemia) in a DIO mouse model. Dietary MI supplementation was efficient in the prevention of inositol intra-tissue depletion, but did not prevent insulin resistance or obesity efficiently in this mouse model. PMID:25990651

  14. Structurally abnormal human autosomes

    SciTech Connect

    1993-12-31

    Chapter 25, discusses structurally abnormal human autosomes. This discussion includes: structurally abnormal chromosomes, chromosomal polymorphisms, pericentric inversions, paracentric inversions, deletions or partial monosomies, cri du chat (cat cry) syndrome, ring chromosomes, insertions, duplication or pure partial trisomy and mosaicism. 71 refs., 8 figs.

  15. High-speed quantum-random number generation by continuous measurement of arrival time of photons

    SciTech Connect

    Yan, Qiurong; Zhao, Baosheng; Hua, Zhang; Liao, Qinghong; Yang, Hao

    2015-07-15

    We demonstrate a novel high speed and multi-bit optical quantum random number generator by continuously measuring arrival time of photons with a common starting point. To obtain the unbiased and post-processing free random bits, the measured photon arrival time is converted into the sum of integral multiple of a fixed period and a phase time. Theoretical and experimental results show that the phase time is an independent and uniform random variable. A random bit extraction method by encoding the phase time is proposed. An experimental setup has been built and the unbiased random bit generation rate could reach 128 Mb/s, with random bit generation efficiency of 8 bits per detected photon. The random numbers passed all tests in the statistical test suite.

  16. High-speed quantum-random number generation by continuous measurement of arrival time of photons.

    PubMed

    Yan, Qiurong; Zhao, Baosheng; Hua, Zhang; Liao, Qinghong; Yang, Hao

    2015-07-01

    We demonstrate a novel high speed and multi-bit optical quantum random number generator by continuously measuring arrival time of photons with a common starting point. To obtain the unbiased and post-processing free random bits, the measured photon arrival time is converted into the sum of integral multiple of a fixed period and a phase time. Theoretical and experimental results show that the phase time is an independent and uniform random variable. A random bit extraction method by encoding the phase time is proposed. An experimental setup has been built and the unbiased random bit generation rate could reach 128 Mb/s, with random bit generation efficiency of 8 bits per detected photon. The random numbers passed all tests in the statistical test suite. PMID:26233362

  17. Large-scale magnetic fields at high Reynolds numbers in magnetohydrodynamic simulations

    NASA Astrophysics Data System (ADS)

    Hotta, H.; Rempel, M.; Yokoyama, T.

    2016-03-01

    The 11-year solar magnetic cycle shows a high degree of coherence in spite of the turbulent nature of the solar convection zone. It has been found in recent high-resolution magnetohydrodynamics simulations that the maintenance of a large-scale coherent magnetic field is difficult with small viscosity and magnetic diffusivity (≲1012square centimenters per second). We reproduced previous findings that indicate a reduction of the energy in the large-scale magnetic field for lower diffusivities and demonstrate the recovery of the global-scale magnetic field using unprecedentedly high resolution. We found an efficient small-scale dynamo that suppresses small-scale flows, which mimics the properties of large diffusivity. As a result, the global-scale magnetic field is maintained even in the regime of small diffusivities—that is, large Reynolds numbers.

  18. Large-scale magnetic fields at high Reynolds numbers in magnetohydrodynamic simulations.

    PubMed

    Hotta, H; Rempel, M; Yokoyama, T

    2016-03-25

    The 11-year solar magnetic cycle shows a high degree of coherence in spite of the turbulent nature of the solar convection zone. It has been found in recent high-resolution magnetohydrodynamics simulations that the maintenance of a large-scale coherent magnetic field is difficult with small viscosity and magnetic diffusivity (≲10 (12) square centimenters per second). We reproduced previous findings that indicate a reduction of the energy in the large-scale magnetic field for lower diffusivities and demonstrate the recovery of the global-scale magnetic field using unprecedentedly high resolution. We found an efficient small-scale dynamo that suppresses small-scale flows, which mimics the properties of large diffusivity. As a result, the global-scale magnetic field is maintained even in the regime of small diffusivities-that is, large Reynolds numbers. PMID:27013727

  19. Boundary layer Reynolds stress composition at high and low Reynolds numbers

    NASA Astrophysics Data System (ADS)

    Priyadarshana, Paththage; Klewicki, Joseph

    2003-11-01

    Properties of the motions contributing to the Reynolds stresses (-\\overlineuv) in high and low Reynolds number (R_θ) turbulent boundary layers are studied through physical experiments. The low R_θ measurements (R_θ = 2870) were acquired in a laboratory wind tunnel, while the high R_θ data (R_θ ≃ 5 × 10^6) were acquired at the SLTEST site, Utah. At each R_θ, comparisons are made at yp / 2 and 2y_p, where yp is the peak position of -\\overlineuv. Scale separation effects associated with increasing R_θ are analyzed via spectra, and by using high and low-pass filtering. The predominant motions underlying the stress undergo a significant shift from large to intermediate scales as R_θ becomes large. Specifically, the peak in the u-v cospectrum is close to the peak in the u power spectrum at low R_θ but shifts to near the peak in the v power spectrum at high R_θ. The low R_θ fractional quadrant -\\overlineuv contributions agree well with published results. High R_θ effects are observed in the fractional contributions through an increase in their magnitudes in each quadrant. Near the wall, an increase in outward interactions is observed at high R_θ. Overall, the contributions to -\\overlineuv are shown to undergo significant variations at comparable wall normal locations (relative to y_p) at the two Reynolds numbers. This work was supported by the Office of Naval Research, grant monitor R. Joslin.

  20. Chromosomal abnormalities in child psychiatric patients.

    PubMed

    Hong, K E; Kim, J H; Moon, S Y; Oh, S K

    1999-08-01

    To determine the frequency of chromosomal abnormalities in a child psychiatric population, and to evaluate possible associations between types of abnormalities and patient's clinical characteristics, cytogenetic examination was performed on 604 patients. Demographic data, reasons for karyotyping, clinical signs, and other patient characteristics were assessed and correlated with the results from karyotyping. Chromosomal abnormalities were found in 69 patients (11.3%); these were structural in 49 cases and numerical in 20. Inversion of chromosome nine was found in 15 subjects, trisomy of chromosome 21 in 11, and fragile X in five patients. When karyotyping was performed because of intellectual impairment or multiple developmental delay, significantly more abnormalities were found than average; when performed because autistic disorder was suspected, the number of abnormalities was significantly fewer. There were no differences in clinical variables between structural and numerical abnormalities, nor among nine types of chromosomal abnormalities, except that numerical abnormalities and polymorphism were found at a later age, and that walking was more delayed and IQ was lower in patients with Down syndrome. Clinicians should be aware of the possible presence of chromosomal abnormalities in child psychiatric populations; the close collaboration with geneticists and the use of more defined guidelines for cytogenetic investigation are important. PMID:10485616

  1. Turbulent mixing due to Holmboe wave instability in stratified shear flows at high Reynolds numbers

    NASA Astrophysics Data System (ADS)

    Salehipour, Hesam; Caulfield, Colm-Cille; Peltier, W. Richard

    2015-11-01

    We consider numerically the transition to turbulence and associated mixing in parallel stratified shear flows with hyperbolic tangent initial velocity and density distributions. When the characteristic length scale of density variation is sufficiently sharper than that of the velocity variation, this flow is primarily susceptible to Holmboe wave instability (HWI) which perturbs the interface to exhibit characteristic cusped interfacial waves. Unlike previous low- Re experimental and numerical studies, in the high- Re regime in which our DNS analyses are performed, the primary HWI triggers a vigorous yet markedly more long-lived turbulent event compared to its better known relative, the Kelvin-Helmholtz instability (KHI). HWI `scours' the primary density interface, leading to substantial irreversible mixing and vertical transport of density displaced above and below the (robust) primary density interface which is comparable in both absolute terms and relative efficiency to the mixing associated with an equivalent KHI. Our results establish categorically that, provided the Reynolds number is high enough, shear layers with sharp density interfaces and associated locally high values of the gradient Richardson number are sites of substantial and efficient irreversible mixing. H.S. is grateful to the David Crighton Fellowship from DAMTP, University of Cambridge.

  2. Aerosol formation from high-velocity uranium drops: Comparison of number and mass distributions. Final report

    SciTech Connect

    Rader, D.J.; Benson, D.A.

    1995-05-01

    This report presents the results of an experimental study of the aerosol produced by the combustion of high-velocity molten-uranium droplets produced by the simultaneous heating and electromagnetic launch of uranium wires. These tests are intended to simulate the reduction of high-velocity fragments into aerosol in high-explosive detonations or reactor accidents involving nuclear materials. As reported earlier, the resulting aerosol consists mainly of web-like chain agglomerates. A condensation nucleus counter was used to investigate the decay of the total particle concentration due to coagulation and losses. Number size distributions based on mobility equivalent diameter obtained soon after launch with a Differential Mobility Particle Sizer showed lognormal distributions with an initial count median diameter (CMD) of 0.3 {mu}m and a geometric standard deviation, {sigma}{sub g} of about 2; the CMD was found to increase and {sigma}{sub g} decrease with time due to coagulation. Mass size distributions based on aerodynamic diameter were obtained for the first time with a Microorifice Uniform Deposit Impactor, which showed lognormal distributions with mass median aerodynamic diameters of about 0.5 {mu}m and an aerodynamic geometric standard deviation of about 2. Approximate methods for converting between number and mass distributions and between mobility and aerodynamic equivalent diameters are presented.

  3. Experimental investigation of acoustic streaming in a cylindrical wave guide up to high streaming Reynolds numbers.

    PubMed

    Reyt, Ida; Bailliet, Hélène; Valière, Jean-Christophe

    2014-01-01

    Measurements of streaming velocity are performed by means of Laser Doppler Velocimetry and Particle Image Velociimetry in an experimental apparatus consisting of a cylindrical waveguide having one loudspeaker at each end for high intensity sound levels. The case of high nonlinear Reynolds number ReNL is particularly investigated. The variation of axial streaming velocity with respect to the axial and to the transverse coordinates are compared to available Rayleigh streaming theory. As expected, the measured streaming velocity agrees well with the Rayleigh streaming theory for small ReNL but deviates significantly from such predictions for high ReNL. When the nonlinear Reynolds number is increased, the outer centerline axial streaming velocity gets distorted towards the acoustic velocity nodes until counter-rotating additional vortices are generated near the acoustic velocity antinodes. This kind of behavior is followed by outer streaming cells only and measurements in the near wall region show that inner streaming vortices are less affected by this substantial evolution of fast streaming pattern. Measurements of the transient evolution of streaming velocity provide an additional insight into the evolution of fast streaming. PMID:24437742

  4. Rayleigh-Bénard convection at high Prandtl numbers in circular and square geometry

    NASA Astrophysics Data System (ADS)

    Johnston, Stephen R.; Fonda, Enrico; Sreenivasan, Katepalli R.; Ranjan, Devesh

    2015-11-01

    Experiments using water and simulations have shown that flow structures and turbulent fluctuations in Rayleigh-Bénard convection are affected by the shape of the container. We study the effect of the geometry in both square and cylindrical test cells of aspect ratio of order unity in high Prandtl fluids (up to 104). Flow visualization using a photochromic dye seeded throughout the fluid allows us to uninvasively study the evolution of the large scale structures. We discuss the observations in the two geometries and compare them with previous observations at low Prandtl numbers.

  5. A high-Reynolds-number seal test facility: Facility description and preliminary test data

    NASA Technical Reports Server (NTRS)

    Childs, D. W.; Nelson, C.; Noyes, T.; Dressman, J. B.

    1982-01-01

    A facility has been developed for testing the leakage and rotordynamic characteristics of interstage-seal configurations for the HPFTP (High Pressure Fuel Turbopump) of the SSME (Space Shuttle Main Engine). Axial Reynolds numbers on the order of 400,000 are realized in the test facility by using a Dupont freon fluid called Halon (CBrF3). The kinematic viscosity of Halon is of the same order as the liquid hydrogen used in the HPFTP. Initial testing has focused on the current flight configurations (a three-segment, stepped unit) and a convergent-taper candidate.

  6. A parameter identification method for the rotordynamic coefficients of a high Reynolds number hydrostatic bearing

    NASA Technical Reports Server (NTRS)

    Rouvas, C.; Childs, D. W.

    1993-01-01

    In identifying the rotordynamic coefficients of a high-Reynolds-number hydrostatic bearing, fluid-flow induced forces present a unique problem, in that they provide an unmeasureable and uncontrollable excitation to the bearing. An analysis method is developed that effectively eliminates the effects of fluid-flow induced excitation on the estimation of the bearing rotordynamic coefficients, by using power spectral densities. In addition to the theoretical development, the method is verified experimentally by single-frequency testing, and repeatability tests. Results obtained for a bearing are the twelve rotordynamic coefficients (stiffness, damping, and inertia coefficients) as functions of eccentricity ratio, speed, and supply pressure.

  7. A high-copy-number CACTA family transposon in temperate grasses and cereals.

    PubMed Central

    Langdon, Tim; Jenkins, Glyn; Hasterok, Robert; Jones, R Neil; King, Ian P

    2003-01-01

    A lineage of CACTA family transposons has been identified in temperate grasses and cereals, and a full-length representative of the subfamily from Lolium perenne has been sequenced. Both the size and internal organization of the L. perenne element are typical of other CACTA family elements but its high copy number and strong conservation are unexpected. Comparison with homologs in other species suggests that this lineage has adopted a distinct and novel evolutionary strategy, which has allowed it to maintain its presence in genomes over long periods of time. PMID:12663547

  8. High quantum-efficiency photon-number-resolving detector for photonic on-chip information processing.

    PubMed

    Calkins, Brice; Mennea, Paolo L; Lita, Adriana E; Metcalf, Benjamin J; Kolthammer, W Steven; Lamas-Linares, Antia; Spring, Justin B; Humphreys, Peter C; Mirin, Richard P; Gates, James C; Smith, Peter G R; Walmsley, Ian A; Gerrits, Thomas; Nam, Sae Woo

    2013-09-23

    The integrated optical circuit is a promising architecture for the realization of complex quantum optical states and information networks. One element that is required for many of these applications is a high-efficiency photon detector capable of photon-number discrimination. We present an integrated photonic system in the telecom band at 1550 nm based on UV-written silica-on-silicon waveguides and modified transition-edge sensors capable of number resolution and over 40 % efficiency. Exploiting the mode transmission failure of these devices, we multiplex three detectors in series to demonstrate a combined 79 % ± 2 % detection efficiency with a single pass, and 88 % ± 3 % at the operating wavelength of an on-chip terminal reflection grating. Furthermore, our optical measurements clearly demonstrate no significant unexplained loss in this system due to scattering or reflections. This waveguide and detector design therefore allows the placement of number-resolving single-photon detectors of predictable efficiency at arbitrary locations within a photonic circuit - a capability that offers great potential for many quantum optical applications. PMID:24104153

  9. Development of a high-frequency electronic integrator for photon-number resolving detectors

    NASA Astrophysics Data System (ADS)

    Meier, Kristina; Wayne, Michael; Kwiat, Paul

    2016-05-01

    Efficient photon-number-resolving single-photon detectors are a critical resource for optical quantum information processing, e.g., for realizing deterministic single-photon production. Previously, we have developed Visible Light Photon Counters (VLPCs) that can detect single photons with high quantum efficiency. The detector configuration allows photons to initiate multiple electron avalanches simultaneously, creating a signal with a charge proportional to the number of photons detected. One current obstacle is the extraction of the total charge of each pulse at frequencies ranging from 200 MHz to 20 GHz. The charge of each pulse is proportional to the area under the input signal and so we are currently developing an electronic integrator that, with appropriate signal amplification, will produce an output signal of pulses with heights equal to the integral of the VLPC pulse, thereby fully realizing the photon-number resolving capabilities of these detectors. Finally, we are also studying the use of optical annealing to reduce the detector's dark counts.

  10. Instability of thermocapillary convection in long liquid bridges of high Prandtl number fluids in microgravity

    NASA Astrophysics Data System (ADS)

    Nishino, Koichi; Yano, Taishi; Kawamura, Hiroshi; Matsumoto, Satoshi; Ueno, Ichiro; Ermakov, Michael K.

    2015-06-01

    This paper reports experimental results on the instability of thermocapillary convection in long half-zone liquid bridges of high Prandtl number fluids (Pr=67, 112 and 207 for 5, 10 and 20 cSt silicone oils, respectively). The experiments were carried out in microgravity on the International Space Station, which allowed sufficiently long waiting period for the development of instability. Critical temperature differences were measured for liquid bridges of 30 and 50 mm diameters and up to 62.5 mm length. The resultant critical Marangoni numbers (Mac) were obtained for a wide range of aspect ratio (=height/diameter), AR, up to AR=2.0. Linear stability analyses for Pr=67 were also carried out to obtain numerical data for comparison. The present experimental results for Pr=67 indicate 5.0×1031.25) and they are in good agreement with the present linear stability analysis result. In contrast, the present results are considerably smaller than the previous data (Pr=74) taken in the Space Shuttle experiments. It is shown that this difference is due to the effect of heating rate of the liquid bridge. The data for oscillation frequency and azimuthal mode number are also presented. The non-dimensional oscillation frequencies as well as Mac for Pr=67 have shown a sudden decrease at around AR=1.25, suggesting the bifurcation of neutral stability curves.

  11. DNS/LES Simulations of Separated Flows at High Reynolds Numbers

    NASA Technical Reports Server (NTRS)

    Balakumar, P.

    2015-01-01

    Direct numerical simulations (DNS) and large-eddy simulations (LES) simulations of flow through a periodic channel with a constriction are performed using the dynamic Smagorinsky model at two Reynolds numbers of 2800 and 10595. The LES equations are solved using higher order compact schemes. DNS are performed for the lower Reynolds number case using a fine grid and the data are used to validate the LES results obtained with a coarse and a medium size grid. LES simulations are also performed for the higher Reynolds number case using a coarse and a medium size grid. The results are compared with an existing reference data set. The DNS and LES results agreed well with the reference data. Reynolds stresses, sub-grid eddy viscosity, and the budgets for the turbulent kinetic energy are also presented. It is found that the turbulent fluctuations in the normal and spanwise directions have the same magnitude. The turbulent kinetic energy budget shows that the production peaks near the separation point region and the production to dissipation ratio is very high on the order of five in this region. It is also observed that the production is balanced by the advection, diffusion, and dissipation in the shear layer region. The dominant term is the turbulent diffusion that is about two times the molecular dissipation.

  12. Measurement of High Reynolds Number Near-Field Turbulent Sphere Wakes under Stratified Conditions

    NASA Astrophysics Data System (ADS)

    Kalumuck, Kenneth; Brandt, Alan; Decker, Kirk; Shipley, Kara

    2015-11-01

    To characterize the near-field of a stratified wake at Reynolds numbers, Re = 2 x 105 - 106, experiments were conducted with a large diameter (0.5 m) sphere towed through a thermally stratified fresh water lake. Stratification produced BV frequencies, N, up to 0.07/s (42 cph) resulting in Froude numbers F = U/ND >= 15. The submerged sphere and associated instrumentation including two Acoustic Doppler Velocimeters (ADVs) and an array of fast response thermistors were affixed to a common frame towed over a range of speeds. Three components of the instantaneous wake velocities were obtained simultaneously at two cross-wake locations with the ADVs while density fluctuations were inferred from temperature measurements made by the thermistors. These measurements were used to determine the mean, rms, and spectra of all three components of the turbulent velocity field and density fluctuations at multiple locations. The turbulence power spectra follow the expected -5/3 slope with wavenumber. Existing stratified near-field wake data for spheres are for Re =104 and less, and only a very limited set of data under unstratified conditions exists at these large values of Re. Those data are primarily measurements of the sphere drag, surface pressure distribution, and separation rather than in wake turbulence. Advances in CFD modeling have enabled simulations at these high Reynolds numbers without quantitative data available for validation. Sponsored by ONR Turbulence and Wakes program.

  13. Exponential high-order compact scheme on nonuniform grids for the steady MHD duct flow problems with high Hartmann numbers

    NASA Astrophysics Data System (ADS)

    Zhou, K.; Ni, S. H.; Tian, Z. F.

    2015-11-01

    In this article, we establish an exponential high-order compact (EHOC) difference scheme on non-uniform grids for the solution of the coupled equations representing the steady incompressible, viscous magnetohydrodynamic (MHD) flow through a straight channel of rectangular section. A main advantage of the non-uniform grids-based EHOC scheme is that it could use coarser mesh to capture the details within the computational domain for the MHD flow problems with high Hartmann numbers. Numerical experiments are carried out to validate the performance of the currently proposed scheme. Computation results of the MHD flow in the 2D square-channel problems are presented for Hartmann numbers ranging from 10 to 106. The numerical solutions obtained with the newly developed EHOC scheme are also compared with analytic solutions and numerical results by other available methods in the literature. All of these numerical results demonstrate that the currently proposed scheme is accurate, efficient and robust for the wide range of Hartmann numbers 10 to 106.

  14. High-fidelity simulations of moving and flexible airfoils at low Reynolds numbers

    NASA Astrophysics Data System (ADS)

    Visbal, Miguel R.; Gordnier, Raymond E.; Galbraith, Marshall C.

    2009-05-01

    The present paper highlights results derived from the application of a high-fidelity simulation technique to the analysis of low-Reynolds-number transitional flows over moving and flexible canonical configurations motivated by small natural and man-made flyers. This effort addresses three separate fluid dynamic phenomena relevant to small fliers, including: laminar separation and transition over a stationary airfoil, transition effects on the dynamic stall vortex generated by a plunging airfoil, and the effect of flexibility on the flow structure above a membrane airfoil. The specific cases were also selected to permit comparison with available experimental measurements. First, the process of transition on a stationary SD7003 airfoil section over a range of Reynolds numbers and angles of attack is considered. Prior to stall, the flow exhibits a separated shear layer which rolls up into spanwise vortices. These vortices subsequently undergo spanwise instabilities, and ultimately breakdown into fine-scale turbulent structures as the boundary layer reattaches to the airfoil surface. In a time-averaged sense, the flow displays a closed laminar separation bubble which moves upstream and contracts in size with increasing angle of attack for a fixed Reynolds number. For a fixed angle of attack, as the Reynolds number decreases, the laminar separation bubble grows in vertical extent producing a significant increase in drag. For the lowest Reynolds number considered ( Re c = 104), transition does not occur over the airfoil at moderate angles of attack prior to stall. Next, the impact of a prescribed high-frequency small-amplitude plunging motion on the transitional flow over the SD7003 airfoil is investigated. The motion-induced high angle of attack results in unsteady separation in the leading edge and in the formation of dynamic-stall-like vortices which convect downstream close to the airfoil. At the lowest value of Reynolds number ( Re c = 104), transition effects are

  15. High-fidelity simulations of moving and flexible airfoils at low Reynolds numbers

    NASA Astrophysics Data System (ADS)

    Visbal, Miguel R.; Gordnier, Raymond E.; Galbraith, Marshall C.

    The present paper highlights results derived from the application of a high-fidelity simulation technique to the analysis of low-Reynolds-number transitional flows over moving and flexible canonical configurations motivated by small natural and man-made flyers. This effort addresses three separate fluid dynamic phenomena relevant to small fliers, including: laminar separation and transition over a stationary airfoil, transition effects on the dynamic stall vortex generated by a plunging airfoil, and the effect of flexibility on the flow structure above a membrane airfoil. The specific cases were also selected to permit comparison with available experimental measurements. First, the process of transition on a stationary SD7003 airfoil section over a range of Reynolds numbers and angles of attack is considered. Prior to stall, the flow exhibits a separated shear layer which rolls up into spanwise vortices. These vortices subsequently undergo spanwise instabilities, and ultimately breakdown into fine-scale turbulent structures as the boundary layer reattaches to the airfoil surface. In a timeaveraged sense, the flow displays a closed laminar separation bubble which moves upstream and contracts in size with increasing angle of attack for a fixed Reynolds number. For a fixed angle of attack, as the Reynolds number decreases, the laminar separation bubble grows in vertical extent producing a significant increase in drag. For the lowest Reynolds number considered (Re_c = 10^4), transition does not occur over the airfoil at moderate angles of attack prior to stall. Next, the impact of a prescribed high-frequency small-amplitude plunging motion on the transitional flow over the SD7003 airfoil is investigated. The motioninduced high angle of attack results in unsteady separation in the leading edge and in the formation of dynamic-stalllike vortices which convect downstream close to the airfoil. At the lowest value of Reynolds number (Re_c = 10^4), transition effects are

  16. Stark broadening of high-principal-quantum-number n-alpha lines of hydrogen.

    NASA Technical Reports Server (NTRS)

    Lasalle, T. R.; Nee, T.-J.; Griem, H. R.

    1973-01-01

    High n-alpha lines (transitions n + 1 to n) with quantum numbers n between 50 and 250 have been observed emanating from galactic H II regions where the electron density and temperature are about 1000/cu cm and 1 eV, respectively. High n-alpha lines have not previously been seen in the laboratory where fairly homogeneous plasmas may be produced and relatively precise measurements of electron densities and temperatures can be made. The present work describes experiments where the first members of the hydrogen line series with lower states n = 10, 11, 12, and 13 have been detected in a laboratory plasma. The width of the 12-alpha line at 88.7 microns could be measured and was consistent with calculated broadening from elastic electron collisions and quasi-static ion effects.

  17. On large-scale dynamo action at high magnetic Reynolds number

    SciTech Connect

    Cattaneo, F.; Tobias, S. M.

    2014-07-01

    We consider the generation of magnetic activity—dynamo waves—in the astrophysical limit of very large magnetic Reynolds number. We consider kinematic dynamo action for a system consisting of helical flow and large-scale shear. We demonstrate that large-scale dynamo waves persist at high Rm if the helical flow is characterized by a narrow band of spatial scales and the shear is large enough. However, for a wide band of scales the dynamo becomes small scale with a further increase of Rm, with dynamo waves re-emerging only if the shear is then increased. We show that at high Rm, the key effect of the shear is to suppress small-scale dynamo action, allowing large-scale dynamo action to be observed. We conjecture that this supports a general 'suppression principle'—large-scale dynamo action can only be observed if there is a mechanism that suppresses the small-scale fluctuations.

  18. High Reynolds Number Hybrid Laminar Flow Control (HLFC) Flight Experiment. Report 2; Aerodynamic Design

    NASA Technical Reports Server (NTRS)

    1999-01-01

    This document describes the aerodynamic design of an experimental hybrid laminar flow control (HLFC) wing panel intended for use on a Boeing 757 airplane to provide a facility for flight research on high Reynolds number HLFC and to demonstrate practical HLFC operation on a full-scale commercial transport airplane. The design consists of revised wing leading edge contour designed to produce a pressure distribution favorable to laminar flow, definition of suction flow requirements to laminarize the boundary layer, provisions at the inboard end of the test panel to prevent attachment-line boundary layer transition, and a Krueger leading edge flap that serves both as a high lift device and as a shield to prevent insect accretion on the leading edge when the airplane is taking off or landing.

  19. Opposing shear-induced forces dominate inertial focusing in curved channels and high Reynolds numbers

    NASA Astrophysics Data System (ADS)

    Keinan, Eliezer; Ezra, Elishai; Nahmias, Yaakov

    2015-11-01

    Inertial focusing is the migration of particles in fluid toward equilibrium, where current theory predicts that shear-induced and wall-induced lift forces are balanced. First reported in 1961, this Segre-Silberberg effect is particularly useful for microfluidic isolation of cells and particles. Interestingly, recent work demonstrated particle focusing at high Reynolds numbers that cannot be explained by current theory. In this work, we show that non-monotonous velocity profiles, such as those developed in curved channels, create peripheral velocity maxima in which opposing shear-induced forces dominate over wall effects. Similarly, entry effects amplified in high Reynolds flow produce an equivalent trapping mechanism in short, straight channels. This focusing mechanism in the developing flow regime enables a 10-fold miniaturization of inertial focusing devices, while our model corrects long-standing misconceptions about the nature of mechanical forces governing inertial focusing in curved channels.

  20. Simulation study of magnetic reconnection in high magnetic Reynolds number plasmas

    NASA Astrophysics Data System (ADS)

    Nakabo, T.; Kusano, K.; Miyoshi, T.; Vekstein, G.

    2013-12-01

    Magnetic reconnection is an important process for dynamics in space and laboratory plasmas. Magnetic reconnection is basically dominated by magnetic diffusion at thin current sheet as proposed by Sweet (1958) and Parker (1963). According to their theory, the reconnection rate must be inversely proportional to the square root of the magnetic Reynolds number (S). In magnetosphere and the solar corona, however, in spite of high magnetic Reynolds number (>10^12), reconnection rate is measured to be about 10^-2 that is much higher than the Sweet and Parker's prediction. Although Petschek proposed that the slow mode shock may accelerate reconnection, numerical simulations suggested that the Petschek's type reconnection cannot be sustained with uniform resistivity. On the other hand, it is pointed out that in high magnetic Reynolds number, the thin current sheet becomes unstable to the so-called secondary tearing instability, which generates many plasmoids and drives a sort of fast reconnection. Although Baty (2012) recently investigated the possibility of Petschek-like structure in relatively high-S (~10^4) regime, it is still unclear whether and how the magnetic reconnection is able to be accelerated in higher-S regime (S>10^5). In this paper, we developed the high-resolution magnetohydrodynamics (MHD) simulation of magnetic reconnection for very high-S (S~10^4-10^6) aiming at revealing the acceleration mechanism of magnetic reconnection. We applied the HLLD Riemann solver, which was developed by Miyoshi and Kusano (2005), to the high resolution two-dimensional MHD simulation of current sheet dynamics. In our model, the initial state is given by the Harris sheet equilibrium plus perturbation. As a result, in the case for S=10^5, multiple X-line reconnection appears as a result of the secondary tearing instability and magnetic reconnection is accelerated through the formation of multiple magnetic islands as pointed out by the previous studies. Furthermore, we found that

  1. High Reynolds Number Effects on Multi-Hole Probes and Hot Wire Anemometers

    NASA Technical Reports Server (NTRS)

    Ramachandran, N.; Smith, A.; Gerry, G.; Kauffman, W.

    1995-01-01

    The paper reports on the results from an experimental investigation of the response of multi-hole and hot wire probes at high flow Reynolds numbers (Re approx. 10(exp 6)). The limited results available in literature for 5-hole probes are restricted to Re approx. 10(exp 4). The experiment aims to investigate the probe response (in terms of dimensionless pressure ratios, characterizing pitch, and yaw angles and the total and static pressures) at high Re values and to gauge their effect on the calculated velocity vector. Hot wire calibrations were also undertaken with a parametric variation of the flow pressure, velocity and temperature. Different correction and calibration schemes are sought to be tested against the acquired data set. The data is in the analysis stage at the present time. The test provided good benchmark quality data that can be used to test future calibration and testing methods.

  2. High-Schmidt-number scalar transfer in regular and fractal grid turbulence

    NASA Astrophysics Data System (ADS)

    Suzuki, Hiroki; Nagata, Kouji; Sakai, Yasuhiko; Ukai, Ryota

    2010-12-01

    Turbulent mixing of high-Schmidt-number passive scalars in regular and fractal grid turbulence is experimentally investigated using a water channel. A turbulence-generating grid is installed at the entrance of the test section, which is 1.5 m in length and 0.1 m×0.1 m in cross section. Two types of grids are used: one is a regular grid consisting of square-mesh and biplane constructions, and the other is a square-type fractal grid, which was first investigated by Hurst and Vassilicos (2007 Phys. Fluids 19 035103) and Seoud and Vassilicos (2007 Phys. Fluids 19 105108). The two grids have the same solidity of 0.36. The Reynolds number based on the mesh size, ReM=U0Meff/ν, is 2500 in both flows, where U0 is the cross-sectionally averaged mean velocity, Meff is the effective mesh size and ν is the kinematic viscosity. A fluorescent dye (rhodamine B) is homogeneously premixed only in the lower stream and therefore the scalar mixing layers with an initial step profile develop downstream of the grids. The Schmidt number of the dye is O(103). The time-resolved particle image velocimetry and the planar laser-induced fluorescence techniques are used to measure the velocity and concentration fields. The results show that the turbulent mixing in fractal grid turbulence is more strongly enhanced than that in regular grid turbulence for the same mesh Reynolds number ReM. The profile of instantaneous scalar dissipation shows that scalar dissipation takes place locally even in the far downstream region at x/Meff=120 in fractal grid turbulence.

  3. GPU implementation for three-dimensional mantle convection at high Rayleigh number

    NASA Astrophysics Data System (ADS)

    Barnett, G. A.; Wright, G. B.; Yuen, D. A.

    2009-12-01

    The last decade has seen the strong influence exerted by the gaming industry on high-performance scientific computing since the landmark year of 2003 when the speed of floating point operations for GPUs surpassed that of CPUs. Since then, the progress of GPUs has been astounding because of the development of faster components with many flow processing units (cores) and larger memories (240 cores and 4 Gbytes with the NVIDIA Tesla 1060). It is feasible with GPUs to have the potential computing power of around one Teraflop in your office environment for around $5000. In this study we demonstrate the enormous capabilities GPUs offers for certain geophysical fluid dynamics applications. We focus our attention on high Rayleigh number three dimensional mantle convection (ie. Rayleigh-Bénard convection in the infinite Prandtl number limit) in a rectangular box. The model equations are taken from Larsen et al (1997), where a constant viscosity has been assumed, which allows the momentum equations to be decomposed into two coupled Poisson equations involving a scalar potential for computing the velocity. These equations together with the spatial derivatives in the energy equation are approximated with second order finite differences. The whole system is advanced forward in time with an explicit, third order accurate Runge-Kutta scheme, which allows for variable time-stepping. We discuss the method with specific attention given to the solution of the two Poisson equations, which are solved directly with a Fourier transform-based algorithm, eg. Hockney (1965). We compare the implementations of this algorithm and its variations on the GPU vs the CPU and demonstrate how the choice depends on the architecture. We report the results from 3D mantle convection simulations run on a single GPU with Rayleigh number up to 10**7 and grids of size up to 512X512X256 (see figure below). A comparison of the computational time for the GPU code shows a speed up of more than 10 times over the

  4. Flying and swimming animals cruise at a Strouhal number tuned for high power efficiency

    NASA Astrophysics Data System (ADS)

    Taylor, Graham K.; Nudds, Robert L.; Thomas, Adrian L. R.

    2003-10-01

    Dimensionless numbers are important in biomechanics because their constancy can imply dynamic similarity between systems, despite possible differences in medium or scale. A dimensionless parameter that describes the tail or wing kinematics of swimming and flying animals is the Strouhal number, St = fA/U, which divides stroke frequency (f) and amplitude (A) by forward speed (U). St is known to govern a well-defined series of vortex growth and shedding regimes for airfoils undergoing pitching and heaving motions. Propulsive efficiency is high over a narrow range of St and usually peaks within the interval 0.2 < St < 0.4 (refs 3-8). Because natural selection is likely to tune animals for high propulsive efficiency, we expect it to constrain the range of St that animals use. This seems to be true for dolphins, sharks and bony fish, which swim at 0.2 < St < 0.4. Here we show that birds, bats and insects also converge on the same narrow range of St, but only when cruising. Tuning cruise kinematics to optimize St therefore seems to be a general principle of oscillatory lift-based propulsion.

  5. A Monolithic Algorithm for High Reynolds Number Fluid-Structure Interaction Simulations

    NASA Astrophysics Data System (ADS)

    Lieberknecht, Erika; Sheldon, Jason; Pitt, Jonathan

    2013-11-01

    Simulations of fluid-structure interaction problems with high Reynolds number flows are typically approached with partitioned algorithms that leverage the robustness of traditional finite volume method based CFD techniques for flows of this nature. However, such partitioned algorithms are subject to many sub-iterations per simulation time-step, which substantially increases the computational cost when a tightly coupled solution is desired. To address this issue, we present a finite element method based monolithic algorithm for fluid-structure interaction problems with high Reynolds number flow. The use of a monolithic algorithm will potentially reduce the computational cost during each time-step, but requires that all of the governing equations be simultaneously cast in a single Arbitrary Lagrangian-Eulerian (ALE) frame of reference and subjected to the same discretization strategy. The formulation for the fluid solution is stabilized by implementing a Streamline Upwind Galerkin (SUPG) method, and a projection method for equal order interpolation of all of the solution unknowns; numerical and programming details are discussed. Preliminary convergence studies and numerical investigations are presented, to demonstrate the algorithm's robustness and performance. The authors acknowledge support for this project from the Applied Research Laboratory Eric Walker Graduate Fellowship Program.

  6. An Experimental Simulation of Flap Flow on Multielement Airfoils at High Reynolds Number

    NASA Technical Reports Server (NTRS)

    Schneider, S.; Campbell, B.; Bucci, G.; Sullivan, J.

    1994-01-01

    The design of the high lift system has a major impact on the performance of an aircraft yet our understanding of the physics of this flow is still weak. Flow features include interactions between the wakes shed from the upstream elements and the pressure gradients and boundary layers of the downstream elements. Interaction of the turbulent wake of the main element and the flap can cause (1) separation of the flap boundary layer or (2) 'bursting' of the main airfoil wake. Although the first factor is at least partially understood, even the qualitative aspects of (2) remain to be determined. In order to study these phenomena at Reynolds numbers approaching those of flight, a thick high Reynolds number wake is created using a 24 foot flat plate in the long rectangular test section of a 4 ft. by 6 ft subsonic wind tunnel. The design and construction of this test section, plate, and accompanying flap is described. Results obtained in a quarter-scale model were used for design purposes and are also described. Construction of the full scale facility is complete and preliminary results are presented.

  7. Flying and swimming animals cruise at a Strouhal number tuned for high power efficiency.

    PubMed

    Taylor, Graham K; Nudds, Robert L; Thomas, Adrian L R

    2003-10-16

    Dimensionless numbers are important in biomechanics because their constancy can imply dynamic similarity between systems, despite possible differences in medium or scale. A dimensionless parameter that describes the tail or wing kinematics of swimming and flying animals is the Strouhal number, St = fA/U, which divides stroke frequency (f) and amplitude (A) by forward speed (U). St is known to govern a well-defined series of vortex growth and shedding regimes for airfoils undergoing pitching and heaving motions. Propulsive efficiency is high over a narrow range of St and usually peaks within the interval 0.2 < St < 0.4 (refs 3-8). Because natural selection is likely to tune animals for high propulsive efficiency, we expect it to constrain the range of St that animals use. This seems to be true for dolphins, sharks and bony fish, which swim at 0.2 < St < 0.4. Here we show that birds, bats and insects also converge on the same narrow range of St, but only when cruising. Tuning cruise kinematics to optimize St therefore seems to be a general principle of oscillatory lift-based propulsion. PMID:14562101

  8. Furosemide Pharmacokinetics in Adult Rats become Abnormal with an Adverse Intrauterine Environment and Modulated by a Post-Weaning High-Fat Diet.

    PubMed

    DuBois, Barent N; Pearson, Jacob; Mahmood, Tahir; Thornburg, Kent; Cherala, Ganesh

    2016-06-01

    Adult individuals born with intrauterine growth restriction (IUGR) have physiological maladaptations that significantly increase risk of chronic disease. We suggested that such abnormalities in organ function would alter pharmacokinetics throughout life, exacerbated by environmental mismatch. Pregnant and lactating rats were fed either a purified control diet (18% protein) or low-protein diet (9% protein) to produce IUGR offspring. Offspring were weaned onto either laboratory chow (11% fat) or high-fat diet (45% fat). Adult offspring (5 months old) were dosed with furosemide (10 mg/kg i.p.) and serum and urine collected. The overall exposure profile in IUGR males was significantly reduced due to a ~35% increase in both clearance and volume of distribution. Females appeared resistant to the IUGR phenotype. The effects of the high-fat diet trended in the opposite direction to that of IUGR, with increased drug exposure due to decreases in both clearance (31% males, 46% females) and volume of distribution (24% males, 44% females), with a 10% longer half-life in both genders. The alterations in furosemide pharmacokinetics and pharmacodynamics were explained by changes in the expression of renal organic anion transporters 1 and 3, and sodium-potassium-chloride cotransporter-2. In summary, this study suggests that IUGR and diet interact to produce subpopulations with similar body-weights but dissimilar pharmacokinetic profiles; this underlines the limitation of one-size-fits-all dosing which does not account for physiological differences in body composition resulting from IUGR and diet. PMID:26550796

  9. Time-averaged flow over a hydrofoil at high Reynolds number

    NASA Astrophysics Data System (ADS)

    Bourgoyne, Dwayne A.; Hamel, Joshua M.; Ceccio, Steven L.; Dowling, David R.

    2003-12-01

    At high Reynolds number, the flow of an incompressible viscous fluid over a lifting surface is a rich blend of fluid dynamic phenomena. Here, boundary layers formed at the leading edge develop over both the suction and pressure sides of the lifting surface, transition to turbulence, separate near the foil's trailing edge, combine in the near wake, and eventually form a turbulent far-field wake. The individual elements of this process have been the subject of much prior work. However, controlled experimental investigations of these flow phenomena and their interaction on a lifting surface at Reynolds numbers typical of heavy-lift aircraft wings or full-size ship propellers (chord-based Reynolds numbers, Re_C {˜} 10(7{-}10^8) ) are largely unavilable. This paper presents results from an experimental effort to identify and measure the dominant features of the flow over a two-dimensional hydrofoil at nominal Re_C values from near one million to more than 50 million. The experiments were conducted in the US Navy's William B. Morgan Large Cavitation Channel with a solid-bronze hydrofoil (2.1 m chord, 3.0 m span, 17 cm maximum thickness) at flow speeds from 0.25 to 18.3 m s(-1) . The foil section, a modified NACA 16 with a pressure side that is nearly flat and a suction side that terminates in a blunt trailing-edge bevel, approximates the cross-section of a generic naval propeller blade. Time-averaged flow-field measurements drawn from laser-Doppler velocimetry, particle-imaging velocimetry, and static pressure taps were made for two trailing-edge bevel angles (44 (°) and 56 (°) ). These velocity and pressure measurements were concentrated in the trailing-edge and near-wake regions, but also include flow conditions upstream and far downstream of the foil, as well as static pressure distributions on the foil surface and test section walls. Observed Reynolds-number variations in the time-averaged flow over the foil are traced to changes in suction-side boundary

  10. High night temperatures during grain number determination reduce wheat and barley grain yield: a field study.

    PubMed

    García, Guillermo A; Dreccer, M Fernanda; Miralles, Daniel J; Serrago, Román A

    2015-11-01

    Warm nights are a widespread predicted feature of climate change. This study investigated the impact of high night temperatures during the critical period for grain yield determination in wheat and barley crops under field conditions, assessing the effects on development, growth and partitioning crop-level processes driving grain number per unit area (GN). Experiments combined: (i) two contrasting radiation and temperature environments: late sowing in 2011 and early sowing in 2013, (ii) two well-adapted crops with similar phenology: bread wheat and two-row malting barley and (iii) two temperature regimes: ambient and high night temperatures. The night temperature increase (ca. 3.9 °C in both crops and growing seasons) was achieved using purpose-built heating chambers placed on the crop at 19:000 hours and removed at 7:00 hours every day from the third detectable stem node to 10 days post-flowering. Across growing seasons and crops, the average minimum temperature during the critical period ranged from 11.2 to 17.2 °C. Wheat and barley grain yield were similarly reduced under warm nights (ca. 7% °C(-1) ), due to GN reductions (ca. 6% °C(-1) ) linked to a lower number of spikes per m(2) . An accelerated development under high night temperatures led to a shorter critical period duration, reducing solar radiation capture with negative consequences for biomass production, GN and therefore, grain yield. The information generated could be used as a starting point to design management and/or breeding strategies to improve crop adaptation facing climate change. PMID:26111197

  11. Abnormal Behavior in Relation to Cage Size in Rhesus Monkeys

    ERIC Educational Resources Information Center

    Paulk, H. H.; And Others

    1977-01-01

    Examines the effects of cage size on stereotyped and normal locomotion and on other abnormal behaviors in singly caged animals, whether observed abnormal behaviors tend to co-occur, and if the development of an abnormal behavior repertoire leads to reduction in the number of normal behavior categories. (Author/RK)

  12. "Jeopardy" in Abnormal Psychology.

    ERIC Educational Resources Information Center

    Keutzer, Carolin S.

    1993-01-01

    Describes the use of the board game, Jeopardy, in a college level abnormal psychology course. Finds increased student interaction and improved application of information. Reports generally favorable student evaluation of the technique. (CFR)

  13. Abnormal Uterine Bleeding

    MedlinePlus

    ... Abnormal uterine bleeding is any bleeding from the uterus (through your vagina) other than your normal monthly ... or fibroids (small and large growths) in the uterus can also cause bleeding. Rarely, a thyroid problem, ...

  14. Abnormal Uterine Bleeding FAQ

    MedlinePlus

    ... as cancer of the uterus, cervix, or vagina • Polycystic ovary syndrome How is abnormal bleeding diagnosed? Your health care ... before the fetus can survive outside the uterus. Polycystic Ovary Syndrome: A condition characterized by two of the following ...

  15. Application of Gaseous Laser Targets and Optical Diagnostics to Study High Mach Number Unstable Plasma Flows

    SciTech Connect

    Edwards, J; MacKinnon, A; Robey, H

    2001-04-01

    The information that can be obtained from current laser driven high Mach number (compressible) hydrodynamics experiments using solid targets and foams is limited by the need to use X-ray diagnostics. These do well at providing the shape of gross 2D structures which we model well, but are a long way from being able to reveal detailed information at the smaller spatial scales, or in 3D turbulent flows, where most of the modeling uncertainties exist. Remedying this is, and will continue to be, an ongoing research effort. An alternative approach that is not being considered is to use gaseous targets coupled with optical diagnostics. The lower density of gases compared to solids or foams means we can use much larger targets for a given laser energy. This should significantly improve spatial resolution, and the dynamic range of scales that are resolvable. In addition, it may be possible to adapt powerful techniques, such as LIF, used by the low Mach number (incompressible) fluid/gas community so that they work in the high Mach number plasma regime. This would provide much more detailed information on turbulent flows than could be achieved with current X-ray diagnostics. We propose a small research effort to use established techniques such as optical interferometry (absolute electron density), and Schlieren photography (electron density gradient), to study compressible hydrodynamic instabilities. We also propose to explore whether techniques such as LIF may be adapted to the plasma regime, thus providing detailed information, particularly about turbulent flows, that is not currently obtainable in plasmas using X-ray diagnostics. The setting will be radiating blast waves, which avoids costly target fabrication, while promising a high physics payoff to the astrophysics community just from using the established diagnostics alone. We propose to conduct the work in collaboration with Dr Todd Ditmire at the University of Texas at Austin, principally on the Janus laser, and

  16. Chromosomal Abnormalities and Schizophrenia

    PubMed Central

    BASSETT, ANNE S.; CHOW, EVA W.C.; WEKSBERG, ROSANNA

    2011-01-01

    Schizophrenia is a common and serious psychiatric illness with strong evidence for genetic causation, but no specific loci yet identified. Chromosomal abnormalities associated with schizophrenia may help to understand the genetic complexity of the illness. This paper reviews the evidence for associations between chromosomal abnormalities and schizophrenia and related disorders. The results indicate that 22q11.2 microdeletions detected by fluorescence in-situ hybridization (FISH) are significantly associated with schizophrenia. Sex chromosome abnormalities seem to be increased in schizophrenia but insufficient data are available to indicate whether schizophrenia or related disorders are increased in patients with sex chromosome aneuploidies. Other reports of chromosomal abnormalities associated with schizophrenia have the potential to be important adjuncts to linkage studies in gene localization. Advances in molecular cytogenetic techniques (i.e., FISH) have produced significant increases in rates of identified abnormalities in schizophrenia, particularly in patients with very early age at onset, learning difficulties or mental retardation, or dysmorphic features. The results emphasize the importance of considering behavioral phenotypes, including adult onset psychiatric illnesses, in genetic syndromes and the need for clinicians to actively consider identifying chromosomal abnormalities and genetic syndromes in selected psychiatric patients. PMID:10813803

  17. Abnormal uterine bleeding.

    PubMed

    Whitaker, Lucy; Critchley, Hilary O D

    2016-07-01

    Abnormal uterine bleeding (AUB) is a common and debilitating condition with high direct and indirect costs. AUB frequently co-exists with fibroids, but the relationship between the two remains incompletely understood and in many women the identification of fibroids may be incidental to a menstrual bleeding complaint. A structured approach for establishing the cause using the Fédération International de Gynécologie et d'Obstétrique (FIGO) PALM-COEIN (Polyp, Adenomyosis, Leiomyoma, Malignancy (and hyperplasia), Coagulopathy, Ovulatory disorders, Endometrial, Iatrogenic and Not otherwise classified) classification system will facilitate accurate diagnosis and inform treatment options. Office hysteroscopy and increasing sophisticated imaging will assist provision of robust evidence for the underlying cause. Increased availability of medical options has expanded the choice for women and many will no longer need to recourse to potentially complicated surgery. Treatment must remain individualised and encompass the impact of pressure symptoms, desire for retention of fertility and contraceptive needs, as well as address the management of AUB in order to achieve improved quality of life. PMID:26803558

  18. Extracellular Matrix Abnormalities in Schizophrenia

    PubMed Central

    Berretta, Sabina

    2011-01-01

    Emerging evidence points to the involvement of the brain extracellular matrix (ECM) in the pathophysiology of schizophrenia (SZ). Abnormalities affecting several ECM components, including Reelin and chondroitin sulfate proteoglycans (CSPGs), have been described in subjects with this disease. Solid evidence supports the involvement of Reelin, an ECM glycoprotein involved in corticogenesis, synaptic functions and glutamate NMDA receptor regulation, expressed prevalently in distinct populations of GABAergic neurons, which secrete it into the ECM. Marked changes of Reelin expression in SZ have typically been reported in association with GABA-related abnormalities in subjects with SZ and bipolar disorder. Recent findings from our group point to substantial abnormalities affecting CSPGs, a main ECM component, in the amygdala and entorhinal cortex of subjects with schizophrenia, but not bipolar disorder. Striking increases of glial cells expressing CSPGs were accompanied by reductions of perineuronal nets, CSPG- and Reelin-enriched ECM aggregates enveloping distinct neuronal populations. CSPGs developmental and adult functions, including neuronal migration, axon guidance, synaptic and neurotransmission regulation are highly relevant to the pathophysiology of SZ. Together with reports of anomalies affecting several other ECM components, these findings point to the ECM as a key component of the pathology of SZ. We propose that ECM abnormalities may contribute to several aspects of the pathophysiology of this disease, including disrupted connectivity and neuronal migration, synaptic anomalies and altered GABAergic, glutamatergic and dopaminergic neurotransmission. PMID:21856318

  19. Metabarcoding analysis of home composts reveals distinctive fungal communities with a high number of unassigned sequences.

    PubMed

    Langarica-Fuentes, Adrian; Fox, Graeme; Robson, Geoffrey D

    2015-10-01

    Home composting has been strongly advocated in the UK, Europe and North America to divert organic waste away from conventional waste processing. Despite this, little attention has been given to microbial communities and their diversity in these systems. In this study, we examined the diversity of fungal species in 10 different domestic composts by 454 tag-encoded pyrosequencing. We report the recovery of 478 different molecular operational taxonomic units (MOTUs) from the 10 composts with a mean of 176.7 ± 19.6 MOTUs per compost and a mean of 12.9 ± 3.8 unique MOTUs per sample. Microascales (17.21 %), Hypocreales (16.76 %), Sordariales (14.89 %), Eurotiales (11.25 %) and Mortierellales (7.38 %) were the dominant orders in the community, with Pseudallescheria (9.52 %), Penicillium (8.43 %), Mortierella (3.60 %) and Fusarium (3.31 %) being the most abundant genera. Fungal communities in home composts were substantially different to large-scale commercial composts, with thermophilic and thermotolerant fungi present in much lower numbers. Significantly, 46.2 % of all sequences were identified as uncultured fungi or could not be assigned above the family level, suggesting there are a high number of new genera and species in these environments still to be described. PMID:26243286

  20. Optimizing sparse sequencing of single cells for highly multiplex copy number profiling

    PubMed Central

    Baslan, Timour; Kendall, Jude; Ward, Brian; Cox, Hilary; Leotta, Anthony; Rodgers, Linda; Riggs, Michael; D'Italia, Sean; Sun, Guoli; Yong, Mao; Miskimen, Kristy; Gilmore, Hannah; Saborowski, Michael; Dimitrova, Nevenka; Krasnitz, Alexander; Harris, Lyndsay; Wigler, Michael; Hicks, James

    2015-01-01

    Genome-wide analysis at the level of single cells has recently emerged as a powerful tool to dissect genome heterogeneity in cancer, neurobiology, and development. To be truly transformative, single-cell approaches must affordably accommodate large numbers of single cells. This is feasible in the case of copy number variation (CNV), because CNV determination requires only sparse sequence coverage. We have used a combination of bioinformatic and molecular approaches to optimize single-cell DNA amplification and library preparation for highly multiplexed sequencing, yielding a method that can produce genome-wide CNV profiles of up to a hundred individual cells on a single lane of an Illumina HiSeq instrument. We apply the method to human cancer cell lines and biopsied cancer tissue, thereby illustrating its efficiency, reproducibility, and power to reveal underlying genetic heterogeneity and clonal phylogeny. The capacity of the method to facilitate the rapid profiling of hundreds to thousands of single-cell genomes represents a key step in making single-cell profiling an easily accessible tool for studying cell lineage. PMID:25858951

  1. Neutrino properties deduced from the study of lepton number violating processes at low and high energies

    SciTech Connect

    Stoica, Sabin

    2012-11-20

    There is nowadays a significant progress in understanding the neutrino properties. The results of the neutrino oscillation experiments have convincingly showed that neutrinos have mass and oscillate, in contradiction with the Standard Model (SM) assumptions, and these are the first evidences of beyond SM physics. However, fundamental properties of the neutrinos like their absolute mass, their character (are they Dirac or Majorana particles?), their mass hierarchy, the number of neutrino flavors, etc., still remain unknown. In this context there is an increased interest in the study of the lepton number violating (LNV) processes, since they could complete our understanding on the neutrino properties. Since recently, the neutrinoless double beta decay was considered the only process able to distinguish between Dirac or Majorana neutrinos and to give a hint on the absolute mass of the electron neutrino. At present, the increased luminosity of the LHC experiments makes feasible the search of LNV processes at high energy as well. In this lecture I will make a brief review on our present knowledge of the neutrino properties, on the present status of the double-beta decay studies and on the first attempts to search LNV processes at LHC.

  2. Muons in air showers at the Pierre Auger Observatory: Mean number in highly inclined events

    SciTech Connect

    Aab, Alexander

    2015-03-09

    We present the first hybrid measurement of the average muon number in air showers at ultra-high energies, initiated by cosmic rays with zenith angles between 62° and 80° . Our measurement is based on 174 hybrid events recorded simultaneously with the Surface Detector array and the Fluorescence Detector of the Pierre Auger Observatory. The muon number for each shower is derived by scaling a simulated reference profile of the lateral muon density distribution at the ground until it fits the data. A 1019 eV shower with a zenith angle of 67°, which arrives at the Surface Detector array at an altitude of 1450 m above sea level, contains on average (2.68 ± 0.04 ± 0.48 (sys.)) × 107 muons with energies larger than 0.3 GeV. Finally, the logarithmic gain d ln Nµ/d ln E of muons with increasing energy between 4 × 1018 eV and 5 × 1019 eV is measured to be (1.029 ± 0.024 ± 0.030 (sys.)).

  3. Improvements of a nano-scale crossed hot-wire for high Reynolds number measurements

    NASA Astrophysics Data System (ADS)

    Fan, Yuyang; Hultmark, Marcus

    2015-11-01

    Hot-wire anemometry, despite its limited spatial and temporal resolution, is still the preferred tool for high Reynolds number flow measurements, mainly due to the continuous signal. To address the resolution issues, the Nano-Scale Thermal Anemometry Probe (NSTAP) was developed at Princeton University. The NSTAP has a sensing volume more than one order of magnitude smaller than conventional hot-wires, and it has displayed superior performance. However, the NSTAP can only measure a single component of the velocity. Using a novel combining method, a probe that enables two-component velocity measurements has been created (the x-NSTAP). The measurement volume is approximately 50 × 50 × 50 μ m, more than one order of magnitude smaller in all directions compared to conventional crossed hot-wires. The x-NSTAP has been further improved to allow more accurate measurements with the help of flow visualization using a scaled model but matching Reynolds number. Results from turbulent flow measurements with the new x-NSTAP are also presented. Supported under NSF grant CBET-1510100 (program manager Dimitrios Papavassiliou).

  4. Heat transfer predictions for two turbine nozzle geometries at high Reynolds and Mach numbers

    NASA Technical Reports Server (NTRS)

    Boyle, R. J.; Jackson, R.

    1995-01-01

    Predictions of turbine vane and endwall heat transfer and pressure distributions are compared with experimental measurements for two vane geometries. The differences in geometries were due to differences in the hub profile, and both geometries were derived from the design of a high rim speed turbine (HRST). The experiments were conducted in the Isentropic Light Piston Facility (ILPF) at Pyestock at a Reynolds number of 5.3 x 10(exp 6), a Mach number of 1.2, and a wall-to-gas temperature ratio of 0.66. Predictions are given for two different steady-state three-dimensional Navier-Stokes computational analyses. C-type meshes were used, and algebraic models were employed to calculate the turbulent eddy viscosity. The effects of different turbulence modeling assumptions on the predicted results are examined. Comparisons are also given between predicted and measured total pressure distributions behind the vane. The combination of realistic engine geometries and flow conditions proved to be quite demanding in terms of the convergence of the CFD solutions. An appropriate method of grid generation, which resulted in consistently converged CFD solutions, was identified.

  5. Muons in air showers at the Pierre Auger Observatory: Mean number in highly inclined events

    DOE PAGESBeta

    Aab, Alexander

    2015-03-09

    We present the first hybrid measurement of the average muon number in air showers at ultra-high energies, initiated by cosmic rays with zenith angles between 62° and 80° . Our measurement is based on 174 hybrid events recorded simultaneously with the Surface Detector array and the Fluorescence Detector of the Pierre Auger Observatory. The muon number for each shower is derived by scaling a simulated reference profile of the lateral muon density distribution at the ground until it fits the data. A 1019 eV shower with a zenith angle of 67°, which arrives at the Surface Detector array at anmore » altitude of 1450 m above sea level, contains on average (2.68 ± 0.04 ± 0.48 (sys.)) × 107 muons with energies larger than 0.3 GeV. Finally, the logarithmic gain d ln Nµ/d ln E of muons with increasing energy between 4 × 1018 eV and 5 × 1019 eV is measured to be (1.029 ± 0.024 ± 0.030 (sys.)).« less

  6. High-Order Photonic W-states for Random Number Generation

    NASA Astrophysics Data System (ADS)

    Graefe, Markus; Heilmann, Rene; Perez-Leija, Armando; Keil, Robert; Dreisow, Felix; Heinrich, Matthias; Nolte, Stefan; Christodoulides, Demetrios N.; Szameit, Alexander

    2014-05-01

    Multipartite entanglement plays a key role in a number of counter-intuitive phenomena in quantum me- chances. A particular type of multipartite entangled states are the so called W-states which are in generalized form a coherent superposition of N single qubit states exhibiting equal probability amplitudes. The entanglement carried by these quantum entities has the remarkable property of being intrinsically robust to decoherence in one of the qubits. In our work, we experimentally realize high order W-states by forcing single photons to exist in a uniform coherent superposition of N (up to 16) spatial optical modes within a multi-port integrated system. Interestingly, in the generated W-states, a single photon will emerge from any of the N output ports with exactly the same probability. Based on that fact we have additionally developed a scheme for the generation of genuine random bits on chip, without the need of any post-processig. The authenticity of the random numbers is validated by applying the fifteen statistical tests suggested by National Institute of Standard Technology.

  7. Jet Velocity Profile Effects on Spray Characteristics of Impinging Jets at High Reynolds and Weber Numbers

    NASA Astrophysics Data System (ADS)

    Rodrigues, Neil S.; Kulkarni, Varun; Sojka, Paul E.

    2014-11-01

    While like-on-like doublet impinging jet atomization has been extensively studied in the literature, there is poor agreement between experimentally observed spray characteristics and theoretical predictions (Ryan et al. 1995, Anderson et al. 2006). Recent works (Bremond and Villermaux 2006, Choo and Kang 2007) have introduced a non-uniform jet velocity profile, which lead to a deviation from the standard assumptions for the sheet velocity and the sheet thickness parameter. These works have assumed a parabolic profile to serve as another limit to the traditional uniform jet velocity profile assumption. Incorporating a non-uniform jet velocity profile results in the sheet velocity and the sheet thickness parameter depending on the sheet azimuthal angle. In this work, the 1/7th power-law turbulent velocity profile is assumed to provide a closer match to the flow behavior of jets at high Reynolds and Weber numbers, which correspond to the impact wave regime. Predictions for the maximum wavelength, sheet breakup length, ligament diameter, and drop diameter are compared with experimental observations. The results demonstrate better agreement between experimentally measured values and predictions, compared to previous models. U.S. Army Research Office under the Multi-University Research Initiative Grant Number W911NF-08-1-0171.

  8. Heat transfer predictions for two turbine nozzle geometries at high Reynolds and Mach numbers

    NASA Astrophysics Data System (ADS)

    Boyle, R. J.; Jackson, R.

    1995-09-01

    Predictions of turbine vane and endwall heat transfer and pressure distributions are compared with experimental measurements for two vane geometries. The differences in geometries were due to differences in the hub profile, and both geometries were derived from the design of a high rim speed turbine (HRST). The experiments were conducted in the Isentropic Light Piston Facility (ILPF) at Pyestock at a Reynolds number of 5.3 x 10(exp 6), a Mach number of 1.2, and a wall-to-gas temperature ratio of 0.66. Predictions are given for two different steady-state three-dimensional Navier-Stokes computational analyses. C-type meshes were used, and algebraic models were employed to calculate the turbulent eddy viscosity. The effects of different turbulence modeling assumptions on the predicted results are examined. Comparisons are also given between predicted and measured total pressure distributions behind the vane. The combination of realistic engine geometries and flow conditions proved to be quite demanding in terms of the convergence of the CFD solutions. An appropriate method of grid generation, which resulted in consistently converged CFD solutions, was identified.

  9. A Stochastic Model for the Relative Motion of High Stokes Number Particles in Isotropic Turbulence

    NASA Astrophysics Data System (ADS)

    Dhariwal, Rohit; Rani, Sarma; Koch, Donald

    2014-11-01

    In the current study, a novel analytical closure for the diffusion current in the PDF equation is presented that is applicable to high-inertia particle pairs with Stokes numbers Str >> 1 . Here Str is a Stokes number based on the time-scale τr of eddies whose size scales with pair separation r. Using this closure, Langevin equations were solved to evolve particle-pair relative velocities and separations in stationary isotropic turbulence. The Langevin equation approach enables the simulation of the full PDF of pair relative motion, instead of only the first few moments of the PDF as is the case in a moments-based approach. Accordingly, PDFs Ω (U | r) and Ω (Ur | r) are computed for various separations r, where the former is the PDF of relative velocity U and the latter is the PDF of the radial component of relative velocity Ur, both conditioned upon the separation r. Consistent with the DNS study of Sundaram & Collins, the Langevin simulations capture the transition of Ω (U | r) from being Gaussian at integral-scale separations to an exponential PDF at Kolmogorov-scale separations. The radial distribution functions (RDFs) computed from these simulations also show reasonable quantitative agreement with those from the DNS of Fevrier et al.

  10. Time evolution of atmospheric particle number concentration during high-intensity pyrotechnic events

    NASA Astrophysics Data System (ADS)

    Crespo, Javier; Yubero, Eduardo; Nicolás, Jose F.; Caballero, Sandra; Galindo, Nuria

    2014-10-01

    The Mascletàs are high-intensity pyrotechnic events, typical of eastern Spanish festivals, in which thousands of firecrackers are burnt at ground level in an intense, short-time (<8 min) deafening spectacle that generates short-lived, thick aerosol clouds. In this study, the impact of such events on air quality has been evaluated by means of particle number concentration measurements performed close to the venue during the June festival in Alicante (southeastern Spain). Peak concentrations and dilution times observed throughout the Mascletàs have been compared to those measured when conventional aerial fireworks were launched 2 km away from the monitoring site. The impact of the Mascletàs on the total number concentration of particles larger than 0.3 μm was higher (maximum ˜2·104 cm-3) than that of fireworks (maximum ˜2·103 cm-3). The effect of fireworks depended on whether the dominant meteorological conditions favoured the transport of the plume to the measurement location. However, the time required for particle concentrations to return to background levels is longer and more variable for firework displays (minutes to hours) than for the Mascletàs (<25 min).

  11. Factors Influencing the Occurrence of High Numbers of Iodine-Resistant Bacteria in Iodinated Swimming Pools

    PubMed Central

    Favero, Martin S.; Drake, Charles H.

    1966-01-01

    It has been shown that, although iodinated swimming-pool waters are usually free from coliform bacteria and enterococci, the total counts frequently become relatively high. Pseudomonas alcaligenes and Alcaligenes faecalis have been shown to account for most of these high counts. It was of interest, therefore, to compare the microbial flora of four alternately chlorinated and iodinated swimming pools. By means of the membrane filter method and suitable selective media, examinations were made for total viable counts, coliform bacteria, enterococci, staphylococci, Streptococcus salivarius, and P. aeruginosa. Colonies also were picked from membrane filters incubated on standard plate count agar and identified. The results showed that, although viable counts were significantly higher during the iodinated periods, the specific types of bacteria determined were either fewer than or the same as in chlorinated periods. During chlorination, the predominant microbial flora consisted of staphylococci and members of the genus Bacillus. During iodination, however, the P. alcaligenes-A. faecalis group accounted for 92 to 99% of the microbial flora. The accumulation of high numbers of these bacteria was shown to be due to their iodine resistance and their ability to grow rapidly in pool water in the absence of free iodine. PMID:5927040

  12. Electron acceleration in a nonrelativistic shock with very high Alfvén Mach number.

    PubMed

    Matsumoto, Y; Amano, T; Hoshino, M

    2013-11-22

    Electron acceleration associated with various plasma kinetic instabilities in a nonrelativistic shock with very high Alfvén Mach number (M(A)~45) is revealed by means of a two-dimensional fully kinetic particle-in-cell simulation. Electromagnetic (ion Weibel) and electrostatic (ion-acoustic and Buneman) instabilities are strongly activated at the same time in different regions of the two-dimensional shock structure. Relativistic electrons are quickly produced predominantly by the shock surfing mechanism with the Buneman instability at the leading edge of the foot. The energy spectrum has a high-energy tail exceeding the upstream ion kinetic energy accompanying the main thermal population. This gives a favorable condition for the ion-acoustic instability at the shock front, which in turn results in additional energization. The large-amplitude ion Weibel instability generates current sheets in the foot, implying another dissipation mechanism via magnetic reconnection in a three-dimensional shock structure in the very-high-M(A) regime. PMID:24313495

  13. Diffusion velocity correlation for nuclear graphite gasification at high temperature and low Reynolds numbers

    SciTech Connect

    El-Genk, M. S.; Tournier, J. M. P.

    2012-07-01

    The safety analysis of High-Temperature and Very High Temperature gas-cooled Reactors requires reliable estimates of nuclear graphite gasification as a function of temperature, among other parameters, in the unlikely event of an air ingress accident. Although the rates of the prevailing chemical reactions increase exponentially with temperature, graphite gasification at high temperatures is limited by the oxygen diffusion through the boundary layer. The effective diffusion velocity depends on the total flow rate and pressure of the bulk air-gas mixture. This paper develops a semi-empirical Sherwood number correlation for calculating the oxygen diffusion velocity. The correlation is based on a compiled database of the results of convective heat transfer experiments with wires and cylinders of different diameters in air, water and paraffin oil at 0.006 {<=} Re {<=} 1,604 and 0.068 {<=} Sc {<=} 35.2, and of mass transfer experiments at 4.8 {<=} Re {<=} 77 and 1,300 {<=} Sc {<=} 2,000. The developed correlation is within {+-} 8% of the compiled database of 567 data points and consistent with reported gasification rate measurements at higher temperatures in experiments using different size specimens of nuclear graphite grades of NBG-18 and NB-25, IG-11, IG-110 and IG-430 in atmospheric air at 0.08 {<=} Re {<=} 30. Unlike the Graetz solution that gives a constant Sh of 3.66 at Re {<=} 1.0, the present correlation shows Sh decreases monotonically to much lower values with decreasing Re. (authors)

  14. Long-Term Administration of High-Fat Diet Corrects Abnormal Bone Remodeling in the Tibiae of Interleukin-6-Deficient Mice.

    PubMed

    Feng, Wei; Liu, Bo; Liu, Di; Hasegawa, Tomoka; Wang, Wei; Han, Xiuchun; Cui, Jian; Yimin; Oda, Kimimitsu; Amizuka, Norio; Li, Minqi

    2016-01-01

    In this study, we aimed to evaluate the influence of diet-induced obesity on IL-6 deficiency-induced bone remodeling abnormality. Seven-week-old IL-6(-/-) mice and their wild type (WT) littermates were fed a standard diet (SD) or high-fat diet (HFD) for 25 weeks. Lipid formation and bone metabolism in mice tibiae were investigated by histochemical analysis. Both IL-6(-/-) and WT mice fed the HFD showed notable body weight gain, thickened cortical bones, and adipose accumulation in the bone marrow. Notably, the HFD normalized the bone phenotype of IL-6(-/-) mice to that of their WT counterpart, as characterized by a decrease in bone mass and the presence of an obliquely arranged, plate-like morphology in the trabecular bone. Alkaline phosphatase and osteocalcin expressions were attenuated in both genotypes after HFD feeding, especially for the IL-6(-/-) mice. Meanwhile, tartrate-resistant acid phosphatase staining was inhibited, osteoclast apoptosis rate down-regulated (revealed by TUNEL assay), and the proportion of cathepsin K (CK)-positive osteoclasts significantly increased in IL-6(-/-) mice on a HFD as compared with IL-6(-/-) mice on standard chow. Our results demonstrate that HFD-induced obesity reverses IL-6 deficiency-associated bone metabolic disorders by suppressing osteoblast activity, upregulating osteoclastic activity, and inhibiting osteoclast apoptosis. PMID:26416243

  15. Anomalous dissipation and kinetic-energy distribution in pipes at very high Reynolds numbers.

    PubMed

    Chen, Xi; Wei, Bo-Bo; Hussain, Fazle; She, Zhen-Su

    2016-01-01

    A symmetry-based theory is developed for the description of (streamwise) kinetic energy K in turbulent pipes at extremely high Reynolds numbers (Re's). The theory assumes a mesolayer with continual deformation of wall-attached eddies which introduce an anomalous dissipation, breaking the exact balance between production and dissipation. An outer peak of K is predicted above a critical Re of 10^{4}, in good agreement with experimental data. The theory offers an alternative explanation for the recently discovered logarithmic distribution of K. The concept of anomalous dissipation is further supported by a significant modification of the k-ω equation, yielding an accurate prediction of the entire K profile. PMID:26871016

  16. Implications of turbulence interactions: A path toward addressing very high Reynolds number flows

    SciTech Connect

    Zhou, Y

    2006-05-15

    The classical 'turbulence problem' is narrowed down and redefined for scientific and engineering applications. From an application perspective, accurate computation of large-scale transport of the turbulent flows is needed. In this paper, a scaling analysis that allows for the large-scales of very high Reynolds number turbulent flows - to be handled by the available supercomputers is proposed. Current understanding of turbulence interactions of incompressible turbulence, which forms the foundation of our argument, is reviewed. Furthermore, the data redundancy in the inertial range is demonstrated. Two distinctive interactions, namely, the distance and near-grid interactions, are inspected for large-scale simulations. The distant interactions in the subgrid scales in an inertial range can be effectively modelled by an eddy damping. The near-grid interactions must be carefully incorporated.

  17. Experimental Investigation of Primary and Secondary Features in High-Mach-Number Shock-Bubble Interaction

    NASA Astrophysics Data System (ADS)

    Ranjan, Devesh; Niederhaus, John; Motl, Bradley; Anderson, Mark; Oakley, Jason; Bonazza, Riccardo

    2007-01-01

    Experiments to study the compression and unstable evolution of an isolated soap-film bubble containing helium, subjected to a strong planar shock wave (M=2.95) in ambient nitrogen, have been performed in a vertical shock tube of square internal cross section using planar laser diagnostics. The early phase of the interaction process is dominated by the formation of a primary vortex ring due to the baroclinic source of vorticity deposited during the shock-bubble interaction, and the mass transfer from the body of the bubble to the vortex ring. The late time (long after shock interaction) study reveals the presence of a secondary baroclinic source of vorticity at high Mach number which is responsible for the formation of counterrotating secondary and tertiary vortex rings and the subsequent larger rate of elongation of the bubble.

  18. Analogies Between Colloidal Sedimentation and Turbulent Convection at High Prandtl Numbers

    NASA Technical Reports Server (NTRS)

    Tong, P.; Ackerson, B. J.

    1999-01-01

    A new set of coarse-grained equations of motion is proposed to describe concentration and velocity fluctuations in a dilute sedimenting suspension of non-Brownian particles. With these equations, colloidal sedimentation is found to be analogous to turbulent convection at high Prandtl numbers. Using Kraichnan's mixing-length theory, we obtain scaling relations for the diffusive dissipation length delta(sub theta), the velocity variance delta u, and the concentration variance delta phi. The obtained scaling laws over varying particle radius alpha and volume fraction phi(sub ) are in excellent agreement with the recent experiment by Segre, Herbolzheimer, and Chaikin. The analogy between colloidal sedimentation and turbulent convection gives a simple interpretation for the existence of a velocity cut-off length, which prevents hydrodynamic dispersion coefficients from being divergent. It also provides a coherent framework for the study of sedimentation dynamics in different colloidal systems.

  19. Particle-number conserving analysis of the high-spin structure of 159Ho

    NASA Astrophysics Data System (ADS)

    Zhang, Zhen-Hua

    2016-05-01

    The high-spin rotational bands in odd-Z nuclei 159Ho (Z = 67) are investigated using the cranked shell model with the pairing correlations treated by a particle-number conserving method, in which the blocking effects are taken into account exactly. The experimental moments of inertia and alignments and their variations with the rotational frequency ħω are reproduced very well by the calculations. The splitting between the signature partners of the yrast band 7 /2- [ 523 ] is discussed and the splitting of the excited band 7 /2+ [ 404 ] above ħω ∼ 0.30 MeV is predicted due to the level crossing with 1 /2+ [ 411 ]. The calculated B (E 2) transition probabilities are also suggested for future experiments.

  20. Preliminary engineering study: Quick opening valve MSFC high Reynolds number wind tunnel

    NASA Technical Reports Server (NTRS)

    1983-01-01

    FluiDyne Engineering Corporation has conducted a preliminary engineering study of a quick-opening valve for the MSFC High Reynolds Number Wind Tunnel under NASA Contract NAS8-35056. The subject valve is intended to replace the Mylar diaphragm system as the flow initiation device for the tunnel. Only valves capable of opening within 0.05 sec. and providing a minimum of 11.4 square feet of flow area were considered. Also, the study focused on valves which combined the quick-opening and tight shutoff features in a single unit. A ring sleeve valve concept was chosen for refinement and pricing. Sealing for tight shutoff, ring sleeve closure release and sleeve actuation were considered. The resulting cost estimate includes the valve and requisite modifications to the facility to accommodate the valve as well as the associated design and development work.

  1. High-order simulations of low Reynolds number membrane airfoils under prescribed motion

    NASA Astrophysics Data System (ADS)

    Jaworski, Justin W.; Gordnier, Raymond E.

    2012-05-01

    The aerodynamics and aeroelastic response of a membrane wing under prescribed motion are investigated using a high-order, two-dimensional Navier-Stokes solver coupled to a geometrically nonlinear membrane model. The impact of increasing Reynolds number on the vortex dynamics and unsteady aerodynamic loads is examined for moderate-amplitude plunge and combined pitch-plunge motions at low frequency. Simulation results are compared with classical thin airfoil theory and highlight the differences between rigid and flexible membrane airfoils undergoing small and moderate amplitude motions. The present study demonstrates the ability of lifting membrane surface flexibility to enhance thrust production and propulsive efficiency, which may inform the design of flapping wing membrane fliers.

  2. Local isotropy in distorted turbulent boundary layers at high Reynolds number

    NASA Technical Reports Server (NTRS)

    Saddoughi, Seyed G.

    1993-01-01

    This is a report on the continuation of our experimental investigations of the hypothesis of local isotropy in shear flows. This hypothesis, which states that at sufficiently high Reynolds numbers the small-scale structures of turbulent motions are independent of large-scale structures and mean deformations, has been used in theoretical studies of turbulence and computational methods such as large-eddy simulation. Since Kolmogorov proposed his theory, there have been many experiments, conducted in wakes, jets, mixing layers, a tidal channel, and atmospheric and laboratory boundary layers, in which attempts have been made to verify - or refute - the local-isotropy hypothesis. However, a review of the literature over the last five decades indicated that, despite all these experiments in shear flows, there was no consensus in the scientific community regarding this hypothesis, and, therefore, it seemed worthwhile to undertake a fresh experimental investigation into this question.

  3. Dissipative particle dynamics of diffusion-NMR requires high Schmidt-numbers.

    PubMed

    Azhar, Mueed; Greiner, Andreas; Korvink, Jan G; Kauzlarić, David

    2016-06-28

    We present an efficient mesoscale model to simulate the diffusion measurement with nuclear magnetic resonance (NMR). On the level of mesoscopic thermal motion of fluid particles, we couple the Bloch equations with dissipative particle dynamics (DPD). Thereby we establish a physically consistent scaling relation between the diffusion constant measured for DPD-particles and the diffusion constant of a real fluid. The latter is based on a splitting into a centre-of-mass contribution represented by DPD, and an internal contribution which is not resolved in the DPD-level of description. As a consequence, simulating the centre-of-mass contribution with DPD requires high Schmidt numbers. After a verification for fundamental pulse sequences, we apply the NMR-DPD method to NMR diffusion measurements of anisotropic fluids, and of fluids restricted by walls of microfluidic channels. For the latter, the free diffusion and the localisation regime are considered. PMID:27369491

  4. Dissipative particle dynamics of diffusion-NMR requires high Schmidt-numbers

    NASA Astrophysics Data System (ADS)

    Azhar, Mueed; Greiner, Andreas; Korvink, Jan G.; Kauzlarić, David

    2016-06-01

    We present an efficient mesoscale model to simulate the diffusion measurement with nuclear magnetic resonance (NMR). On the level of mesoscopic thermal motion of fluid particles, we couple the Bloch equations with dissipative particle dynamics (DPD). Thereby we establish a physically consistent scaling relation between the diffusion constant measured for DPD-particles and the diffusion constant of a real fluid. The latter is based on a splitting into a centre-of-mass contribution represented by DPD, and an internal contribution which is not resolved in the DPD-level of description. As a consequence, simulating the centre-of-mass contribution with DPD requires high Schmidt numbers. After a verification for fundamental pulse sequences, we apply the NMR-DPD method to NMR diffusion measurements of anisotropic fluids, and of fluids restricted by walls of microfluidic channels. For the latter, the free diffusion and the localisation regime are considered.

  5. Double large field stereoscopic PIV in a high Reynolds number turbulent boundary layer

    NASA Astrophysics Data System (ADS)

    Coudert, S.; Foucaut, J. M.; Kostas, J.; Stanislas, M.; Braud, P.; Fourment, C.; Delville, J.; Tutkun, M.; Mehdi, F.; Johansson, P.; George, W. K.

    2011-01-01

    An experiment on a flat plate turbulent boundary layer at high Reynolds number has been carried out in the Laboratoire de Mecanique de Lille (LML, UMR CNRS 8107) wind tunnel. This experiment was performed jointly with LEA (UMR CNRS 6609) in Poitiers (France) and Chalmers University of Technology (Sweden), in the frame of the WALLTURB European project. The simultaneous recording of 143 hot wires in one transverse plane and of two perpendicular stereoscopic PIV fields was performed successfully. The first SPIV plane is 1 cm upstream of the hot wire rake and the second is both orthogonal to the first one and to the wall. The first PIV results show a blockage effect which based on both statistical results (i.e. mean, RMS and spatial correlation) and a potential model does not seem to affect the turbulence organization.

  6. Drag coefficient of the weakly ionized plasma in the high Knudsen number regime

    SciTech Connect

    Chu, H.-Y.; Si, M.-C.; Lin, S.-B.

    2009-06-15

    The drag force acting on a micron-sized polystyrene particle in the high Knudsen number regime is investigated. Analysis of the particle trajectories in stationary neutral argon gas environment suggests the damping time constant {tau}{proportional_to}p{sup -1.20{+-}}{sup 0.04} and Epstein drag force coefficient {delta}=1.40. The neutral drag coefficient is compared with the drag coefficient measurement in dust-free plasma. The phenomena of the reduced drag in weakly viscous and weakly ionized rf plasma are also observed in this report. It is shown that the slight changes in rf power and pressure would enhance the reduced drag effect, which suggests that there is an additional electrostatic force acting along the particle motion in the plasma.

  7. High Reynolds number droplet de-pinning on textured surfaces: theory and experiments

    NASA Astrophysics Data System (ADS)

    Lee, Sungyon; Wilcox, Benjamin; Xu, Feng; White, Edward

    2014-11-01

    The stability of drops on surfaces subject to forcing by wind and gravity is relevant to heat exchangers, fuel cells, and aircraft icing, and it lacks understanding in a high Reynolds number regime. To experimentally investigate this phenomenon, water drops are placed on the rough aluminum floor of a tiltable wind tunnel and brought to critical conditions for varying drop sizes, inclination angles, and flow speeds. In particular, the evolving 3D droplet shapes under flow are reconstructed based on a laser-speckle interface measurement tool, while the critical flow rates of droplet depinning are also noted. By accounting for the contact angle hysteresis and the pressure build-up in a nearly turbulent boundary layer, the critical depinning flow rate is theoretically predicted and is compared to the experimental results. We also observe and explain the transition of the drop depinning behavior from inertia-dominated to gravity-dominated regimes at non-zero inclination angles.

  8. Kinetic energy and scalar spectra in high Rayleigh number axially homogeneous buoyancy driven turbulence

    NASA Astrophysics Data System (ADS)

    Pawar, Shashikant S.; Arakeri, Jaywant H.

    2016-06-01

    Kinetic energy and scalar spectra from the measurements in high Rayleigh number axially homogeneous buoyancy driven turbulent flow are presented. Kinetic energy and concentration (scalar) spectra are obtained from the experiments wherein density difference is created using brine and fresh water and temperature spectra are obtained from the experiments in which heat is used. Scaling of the frequency spectra of lateral and longitudinal velocity near the tube axis is closer to the Kolmogorov-Obukhov scaling, while the scalar spectra show some evidence of dual scaling, Bolgiano-Obukhov scaling followed by Obukhov-Corrsin scaling. These scalings are also observed in the corresponding second order spatial structure functions of velocity and concentration fluctuations.

  9. The variational multiscale element free Galerkin method for MHD flows at high Hartmann numbers

    NASA Astrophysics Data System (ADS)

    Zhang, Lin; Ouyang, Jie; Zhang, Xiaohua

    2013-04-01

    The aim of the paper is the development of an efficient numerical algorithm for the solution of magnetohydrodynamics (MHD) flow problems with either fully insulating walls or partially insulating and partially conducting walls. Toward this, we first extend the influence domain of the shape function for the element free Galerkin (EFG) method to have arbitrary shape. When the influence factor approaches 1, we find that the EFG shape function almost has the Delta property at the node (i.e. the value of the EFG shape function of the node is nearly equal to 1 at the position of this node) as well as the property of slices in the influence domain of the node (i.e. the EFG shape function in the influence domain of the node is nearly constructed by different functions defined in different slices). Therefore, for MHD flow problems at high Hartmann numbers we follow the idea of the variational multiscale finite element method (VMFEM) to combine the EFG method with the variational multiscale (VM) method, namely the variational multiscale element free Galerkin (VMEFG) method is proposed. Subsequently, in order to validate the proposed method, we compare the obtained approximate solutions with the exact solutions for some problems where such exact solutions are known. Finally, several benchmark problems of MHD flows are simulated and the numerical results indicate that the VMEFG method is stable at moderate and high values of Hartmann number. Another important feature of this method is that the stabilization parameter has appeared naturally via the solution of the fine scale problem. Meanwhile, because this proposed method is a type of meshless method, it can avoid the need for meshing, a very demanding task for complicated geometry problems.

  10. The Spectral Amplitude of Stellar Convection and Its Scaling in the High-Rayleigh-number Regime

    NASA Astrophysics Data System (ADS)

    Featherstone, Nicholas A.; Hindman, Bradley W.

    2016-02-01

    Convection plays a central role in the dynamics of any stellar interior, and yet its operation remains largely hidden from direct observation. As a result, much of our understanding concerning stellar convection necessarily derives from theoretical and computational models. The Sun is, however, exceptional in that regard. The wealth of observational data afforded by its proximity provides a unique test bed for comparing convection models against observations. When such comparisons are carried out, surprising inconsistencies between those models and observations become apparent. Both photospheric and helioseismic measurements suggest that convection simulations may overestimate convective flow speeds on large spatial scales. Moreover, many solar convection simulations have difficulty reproducing the observed solar differential rotation owing to this apparent overestimation. We present a series of three-dimensional stellar convection simulations designed to examine how the amplitude and spectral distribution of convective flows are established within a star’s interior. While these simulations are nonmagnetic and nonrotating in nature, they demonstrate two robust phenomena. When run with sufficiently high Rayleigh number, the integrated kinetic energy of the convection becomes effectively independent of thermal diffusion, but the spectral distribution of that kinetic energy remains sensitive to both of these quantities. A simulation that has converged to a diffusion-independent value of kinetic energy will divide that energy between spatial scales such that low-wavenumber power is overestimated and high-wavenumber power is underestimated relative to a comparable system possessing higher Rayleigh number. We discuss the implications of these results in light of the current inconsistencies between models and observations.

  11. Observations of high droplet number concentrations in Southern Ocean boundary layer clouds

    NASA Astrophysics Data System (ADS)

    Chubb, T.; Huang, Y.; Jensen, J.; Campos, T.; Siems, S.; Manton, M.

    2015-09-01

    Data from the standard cloud physics payload during the NSF/NCAR High-performance Instrumented Airborne Platform for Environmental Research (HIAPER) Pole-to-Pole Observations (HIPPO) campaigns provide a snapshot of unusual wintertime microphysical conditions in the boundary layer over the Southern Ocean. On 29 June 2011, the HIAPER sampled the boundary layer in a region of pre-frontal warm air advection between 58 and 48° S to the south of Tasmania. Cloud droplet number concentrations were consistent with climatological values in the northernmost profiles but were exceptionally high for wintertime in the Southern Ocean at 100-200 cm-3 in the southernmost profiles. Sub-micron (0.0625 m s-1) were most likely responsible for production of sea spray aerosol which influenced the microphysical properties of the boundary layer clouds. The smaller size and higher number concentration of cloud droplets is inferred to increase the albedo of these clouds, and these conditions occur regularly, and are expected to increase in frequency, over windy parts of the Southern Ocean.

  12. Development and validation of an high-performance liquid chromatography-diode array detector method for the simultaneous determination of six phenolic compounds in abnormal savda munziq decoction

    PubMed Central

    Tian, Shuge; Liu, Wenxian; Liu, Feng; Zhang, Xuejia; Upur, Halmuart

    2015-01-01

    Aims: Given the high-effectiveness and low-toxicity of abnormal savda munziq (ASMQ), its herbal formulation has long been used in traditional Uyghur medicine to treat complex diseases, such as cancer, diabetes, and cardiovascular diseases. Settings and Design: ASMQ decoction by reversed-phase high-performance liquid chromatography coupled with a diode array detector was successfully developed for the simultaneous quality assessment of gallic acid, protocatechuic acid, caffeic acid, rutin, rosmarinic acid, and luteolin. The six phenolic compounds were separated on an Agilent TC-C18 reversed-phase analytical column (4.6 × 250 mm, 5 μm) by gradient elution using 0.3% aqueous formic acid (v/v) and 0.3% methanol formic acid (v/v) at 1.0 mL/min. Materials and Methods: The plant material was separately ground and mixed at the following ratios (10): Cordia dichotoma (10.6), Anchusa italic (10.6), Euphorbia humifusa (4.9), Adiantum capillus-veneris (4.9), Ziziphus jujube (4.9), Glycyrrhiza uralensis (7.1), Foeniculum vulgare (4.9), Lavandula angustifolia (4.9), Dracocephalum moldavica L. (4.9), and Alhagi pseudoalhagi (42.3). Statistical Analysis Used: The precisions of all six compounds were <0.60%, and the average recoveries ranged from 99.39% to 104.85%. Highly significant linear correlations were found between component concentrations and specific chromatographic peak areas (R2 > 0.999). Results: The proposed method was successfully applied to determine the levels of six active components in ASMQ. Conclusions: Given the simplicity, precision, specificity, and sensitivity of the method, it can be utilized as a quality control approach to simultaneously determining the six phenolic compounds in AMSQ. PMID:25709227

  13. Mathematics for High School. Intermediate Mathematics, Part 1, Supplementary Unit I. The Development of the Real Number System. Revised Edition.

    ERIC Educational Resources Information Center

    Allen, Frank B.; And Others

    This is a supplementary unit to Mathematics for High School, Intermediate Mathematics, Part 1. In this publication, real numbers and rules for operating them are examined. The study begins by examining whole numbers and some of the properties of addition and multiplication of whole numbers. Most of the basic rules for algebra are developed from…

  14. High quality copy number and genotype data from FFPE samples using Molecular Inversion Probe (MIP) microarrays

    SciTech Connect

    Wang, Yuker; Carlton, Victoria E.H.; Karlin-Neumann, George; Sapolsky, Ronald; Zhang, Li; Moorhead, Martin; Wang, Zhigang C.; Richardson, Andrea L.; Warren, Robert; Walther, Axel; Bondy, Melissa; Sahin, Aysegul; Krahe, Ralf; Tuna, Musaffe; Thompson, Patricia A.; Spellman, Paul T.; Gray, Joe W.; Mills, Gordon B.; Faham, Malek

    2009-02-24

    A major challenge facing DNA copy number (CN) studies of tumors is that most banked samples with extensive clinical follow-up information are Formalin-Fixed Paraffin Embedded (FFPE). DNA from FFPE samples generally underperforms or suffers high failure rates compared to fresh frozen samples because of DNA degradation and cross-linking during FFPE fixation and processing. As FFPE protocols may vary widely between labs and samples may be stored for decades at room temperature, an ideal FFPE CN technology should work on diverse sample sets. Molecular Inversion Probe (MIP) technology has been applied successfully to obtain high quality CN and genotype data from cell line and frozen tumor DNA. Since the MIP probes require only a small ({approx}40 bp) target binding site, we reasoned they may be well suited to assess degraded FFPE DNA. We assessed CN with a MIP panel of 50,000 markers in 93 FFPE tumor samples from 7 diverse collections. For 38 FFPE samples from three collections we were also able to asses CN in matched fresh frozen tumor tissue. Using an input of 37 ng genomic DNA, we generated high quality CN data with MIP technology in 88% of FFPE samples from seven diverse collections. When matched fresh frozen tissue was available, the performance of FFPE DNA was comparable to that of DNA obtained from matched frozen tumor (genotype concordance averaged 99.9%), with only a modest loss in performance in FFPE. MIP technology can be used to generate high quality CN and genotype data in FFPE as well as fresh frozen samples.

  15. Velocity Resolved---Scalar Modeled Simulations of High Schmidt Number Turbulent Transport

    NASA Astrophysics Data System (ADS)

    Verma, Siddhartha

    The objective of this thesis is to develop a framework to conduct velocity resolved - scalar modeled (VR-SM) simulations, which will enable accurate simulations at higher Reynolds and Schmidt (Sc) numbers than are currently feasible. The framework established will serve as a first step to enable future simulation studies for practical applications. To achieve this goal, in-depth analyses of the physical, numerical, and modeling aspects related to Sc " 1 are presented, specifically when modeling in the viscous-convective subrange. Transport characteristics are scrutinized by examining scalar-velocity Fourier mode interactions in Direct Numerical Simulation (DNS) datasets and suggest that scalar modes in the viscous-convective subrange do not directly affect large-scale transport for high Sc . Further observations confirm that discretization errors inherent in numerical schemes can be sufficiently large to wipe out any meaningful contribution from subfilter models. This provides strong incentive to develop more effective numerical schemes to support high Sc simulations. To lower numerical dissipation while maintaining physically and mathematically appropriate scalar bounds during the convection step, a novel method of enforcing bounds is formulated, specifically for use with cubic Hermite polynomials. Boundedness of the scalar being transported is effected by applying derivative limiting techniques, and physically plausible single sub-cell extrema are allowed to exist to help minimize numerical dissipation. The proposed bounding algorithm results in significant performance gain in DNS of turbulent mixing layers and of homogeneous isotropic turbulence. Next, the combined physical/mathematical behavior of the subfilter scalar-flux vector is analyzed in homogeneous isotropic turbulence, by examining vector orientation in the strain-rate eigenframe. The results indicate no discernible dependence on the modeled scalar field, and lead to the identification of the tensor

  16. Measurements of high number densities of ice crystals in the tops of tropical cumulonimbus

    NASA Astrophysics Data System (ADS)

    Knollenberg, R. G.; Kelly, K.; Wilson, J. C.

    1993-05-01

    Imaging and light scattering instruments were used during the January/February 1987 STEP Tropical Experiment at Darwin, Australia, to measure ice crystal size distributions in the tops of tropical cumulonimbus anvils associated with tropical cyclones and related cloud systems. Two light scattering instruments covered particles from 0.1-μm to 78-μm diameter. Particles larger than 50-μm diameter were imaged with a two-dimensional Grey optical array imaging probe. The measurements were made at altitudes ranging from 13 to 18 km at temperatures ranging from -60° to -90°C. Additional measurements made in continental cumulonimbus anvils in the western United States offer a comparative data set. The tropical anvil penetrations revealed surprisingly high concentrations of ice crystals. Number densities were typically greater than 10 cm-3 with up to 100 cm-3 if one includes all particles larger than 0.1 μm and can approach condensation nuclei in total concentration. In order to explain the high number densities, ice crystal nucleation at altitude is proposed with the freezing of fairly concentrated solution droplets in equilibrium at low relative humidities. Any dilute liquid phase is hypothesized to be transitory with a vanishingly short lifetime and limited to cloud levels nearer -40°C. Homogeneous nucleation of ice involving H2SO4 nuclei is attractive in explaining the high number densities of small ice crystals observed near cloud top at temperatures below -60°C. The tropical size distributions were converted to mass using a spherical equivalent size, while the continental anvil data were treated as crystalline plates. Comparisons of the ice water contents integrated from the mass distributions with total water contents measured with NOAA Lyman-alpha instruments require bulk densities equivalent to solid ice for best agreement. Correlation between the two data sets for a number of flight passes was quite good and was further improved by subtraction of water

  17. High-resolution copy number analysis of paired normal-tumor samples from diffuse large B cell lymphoma.

    PubMed

    Sebastián, Elena; Alcoceba, Miguel; Martín-García, David; Blanco, Óscar; Sanchez-Barba, Mercedes; Balanzategui, Ana; Marín, Luis; Montes-Moreno, Santiago; González-Barca, Eva; Pardal, Emilia; Jiménez, Cristina; García-Álvarez, María; Clot, Guillem; Carracedo, Ángel; Gutiérrez, Norma C; Sarasquete, M Eugenia; Chillón, Carmen; Corral, Rocío; Prieto-Conde, M Isabel; Caballero, M Dolores; Salaverria, Itziar; García-Sanz, Ramón; González, Marcos

    2016-01-01

    Copy number analysis can be useful for assessing prognosis in diffuse large B cell lymphoma (DLBCL). We analyzed copy number data from tumor samples of 60 patients diagnosed with DLBCL de novo and their matched normal samples. We detected 63 recurrent copy number alterations (CNAs), including 33 gains, 30 losses, and nine recurrent acquired copy number neutral loss of heterozygosity (CNN-LOH). Interestingly, 20 % of cases acquired CNN-LOH of 6p21 locus, which involves the HLA region. In normal cells, there were no CNAs but we observed CNN-LOH involving some key lymphoma regions such as 6p21 and 9p24.1 (5 %) and 17p13.1 (2.5 %) in DLBCL patients. Furthermore, a model with some specific CNA was able to predict the subtype of DLBCL, 1p36.32 and 10q23.31 losses being restricted to germinal center B cell-like (GCB) DLBCL. In contrast, 8p23.3 losses and 11q24.3 gains were strongly associated with the non-GCB subtype. A poor prognosis was associated with biallelic inactivation of TP53 or 18p11.32 losses, while prognosis was better in cases carrying 11q24.3 gains. In summary, CNA abnormalities identify specific DLBCL groups, and we describe CNN-LOH in germline cells from DLBCL patients that are associated with genes that probably play a key role in DLBCL development. PMID:26573278

  18. Gender Differences in the Prevalence of Electrocardiogram Abnormalities in the Elderly: A Population Survey in India

    PubMed Central

    Sachin Khane, Rupali; Surdi, Anil D.

    2012-01-01

    Background: The health transition in India reflects the growing burden of cardiovascular diseases. It is well-known that there are significant and meaningful differences in the measured electrocardiogram (ECG) parameters between females and males. Specific to ECG diagnosis and ischemia, reports have indicated a higher number of false positive results in female patients than in male patients. This study was aimed at examining gender difference in the prevalence of ECG abnormality in older people who were free of coronary heart disease (CHD) and its associated risk factors. Methods: This study was conducted in Solapur city using 400 apparently healthy asymptomatic subjects with an age range of 45 to 74 years. A resting 12-lead ECG was recorded in supine position in accordance with classical recommendations. The various ECG abnormalities were defined according to Minnesota code. The findings were analyzed using Chi Square test at P<0.05. Results: Out of 400 ECGs recorded, 152 showed abnormalities. The prevalence of ECG abnormalities was significantly (P<0.001) more in males than in females. Major prevalence of ECG abnormalities in males observed were LAD, LVH, sinus bradycardia, LBBB and Q/QS patterns. There was no significant gender difference in the prevalence of other ECG abnormalities. Conclusion: This study has outlined the overall prevalence of ECG abnormalities in males as well as in females in Solapur city. We found highly significant (P<0.001) increase in the prevalence of ECG abnormalities in males as compare to females. PMID:23115437

  19. The effect of hydrodynamic interactions on the average properties of a bidisperse suspension of high Reynolds number, low Weber number bubbles

    NASA Astrophysics Data System (ADS)

    Kumaran, V.; Koch, Donald L.

    1993-05-01

    The hydrodynamic interaction between a pair of nondeformable bubbles (low Weber number limit) in potential flow (high Reynolds number limit) was analyzed. The velocity potential was determined using twin spherical expansions, and the equations of motion were calculated by enforcing the zero net force condition on the surface of the bubbles. The acceleration due to the interaction is expressed in a perturbation series in the parameter (ai/R), where ai is the radius of bubble i, R is the distance between the bubbles, and the leading-order acceleration was found to decrease as (ai/R)4. The effect of potential flow interactions on the trajectory of a pair of bubbles of different sizes (size ratio greater than 1.07 at a Reynolds number of 200) rising due to gravity was studied. A salient feature of the trajectories is that the surfaces of the bubble do not come into contact during the interaction, except when the smaller bubble radius is less than 0.233 times the larger bubble radius when the Reynolds number based on the larger bubble is 200. In the latter case, however, the Reynolds number based on the radius of the smaller bubble is not large enough to justify the potential flow approximation. For interactions where collisions do not occur, the mean-square fluctuating velocity in a uniform suspension and the hydrodynamic diffusivities in a nonuniform suspension were calculated by performing an ensemble average over pair interactions. The pair averaging procedure is valid for dilute suspensions (V≪18/Re, where V is the volume fraction of the bubbles and Re is the Reynolds number based on the bubble radius and its terminal velocity).

  20. Using high time resolution aerosol and number size distribution measurements to estimate atmospheric extinction.

    PubMed

    Malm, William C; McMeeking, Gavin R; Kreidenweis, Sonia M; Levin, Ezra; Carrico, Christian M; Day, Derek E; Collett, Jeffrey L; Lee, Taehyoung; Sullivan, Amy P; Raja, Suresh

    2009-09-01

    Rocky Mountain National Park is experiencing reduced visibility and changes in ecosystem function due to increasing levels of oxidized and reduced nitrogen. The Rocky Mountain Atmospheric Nitrogen and Sulfur (RoMANS) study was initiated to better understand the origins of sulfur and nitrogen species as well as the complex chemistry occurring during transport from source to receptor. As part of the study, a monitoring program was initiated for two 1-month time periods--one during the spring and the other during late summer/fall. The monitoring program included intensive high time resolution concentration measurements of aerosol number size distribution, inorganic anions, and cations, and 24-hr time resolution of PM2.5 and PM10 mass, sulfate, nitrate, carbon, and soil-related elements concentrations. These data are combined to estimate high time resolution concentrations of PM2.5 and PM10 aerosol mass and fine mass species estimates of ammoniated sulfate, nitrate, and organic and elemental carbon. Hour-by-hour extinction budgets are calculated by using these species concentration estimates and measurements of size distribution and assuming internal and external particle mixtures. Summer extinction was on average about 3 times higher than spring extinction. During spring months, sulfates, nitrates, carbon mass, and PM10 - PM2.5 mass contributed approximately equal amounts of extinction, whereas during the summer months, carbonaceous material extinction was 2-3 times higher than other species. PMID:19785272

  1. Radiative Properties of High Wire Number Tungsten Arrays with Implosion Times up to 250 ns

    SciTech Connect

    Beg, F.N.; Coverdale, C.A.; Deeney, C.; Douglas, M.R.; Haines, M.G.; Peterson, D.L.; Roderick, N.F.; Ruiz-Camacho, J.; Spielman, R.B.; Struve, K.W.; Stygar, W.A.

    1999-02-02

    High wire number, 25-mm diameter tungsten wire arrays have been imploded on the 8-MA Saturn generator, operating in a long-pulse mode. By varying the mass load from 710 to 6140 ps/cm, implosion times of 130 to 250 ns have been obtained with implosion velocities of 50 to 25 cn-dys, respectively. These z-pinch implosions produced plasmas with millimeter diameters that radiated 600 to 800 kJ of x-rays, with powers of 20 to 49 TW; the corresponding pulse widths were 19 to 7.5 ns, with risetimes ranging from 6.5 to 4.0 ns. These powers and pulse widths are similar to those achieved with 50 ns implosion times on Saturn. Two-dimensional, radiation- magnetohydrodynamic calculations indicate that the imploding shells in these long implosion time experiments are comparable in width to those in the short pulse cases. This can only be due to lower initial perturbations. A heuristic wire array model suggests that the reduced perturbations, in the long pulse cases, may be due to the individual wire merger occurring well before the acceleration of the shell. The experiments and modeling suggest that 150 to 200 ns implosion time z-pinches could be employed for high-power, x-ray source applications.

  2. A Study of the Unstable Modes in High Mach Number Gaseous Jets and Shear Layers

    NASA Astrophysics Data System (ADS)

    Bassett, Gene Marcel

    1993-01-01

    Instabilities affecting the propagation of supersonic gaseous jets have been studied using high resolution computer simulations with the Piecewise-Parabolic-Method (PPM). These results are discussed in relation to jets from galactic nuclei. These studies involve a detailed treatment of a single section of a very long jet, approximating the dynamics by using periodic boundary conditions. Shear layer simulations have explored the effects of shear layers on the growth of nonlinear instabilities. Convergence of the numerical approximations has been tested by comparing jet simulations with different grid resolutions. The effects of initial conditions and geometry on the dominant disruptive instabilities have also been explored. Simulations of shear layers with a variety of thicknesses, Mach numbers and densities perturbed by incident sound waves imply that the time for the excited kink modes to grow large in amplitude and disrupt the shear layer is taug = (546 +/- 24) (M/4)^{1.7 } (Apert/0.02) ^{-0.4} delta/c, where M is the jet Mach number, delta is the half-width of the shear layer, and A_ {pert} is the perturbation amplitude. For simulations of periodic jets, the initial velocity perturbations set up zig-zag shock patterns inside the jet. In each case a single zig-zag shock pattern (an odd mode) or a double zig-zag shock pattern (an even mode) grows to dominate the flow. The dominant kink instability responsible for these shock patterns moves approximately at the linear resonance velocity, nu_ {mode} = cextnu_ {relative}/(cjet + c_ {ext}). For high resolution simulations (those with 150 or more computational zones across the jet width), the even mode dominates if the even penetration is higher in amplitude initially than the odd perturbation. For low resolution simulations, the odd mode dominates even for a stronger even mode perturbation. In high resolution simulations the jet boundary rolls up and large amounts of external gas are entrained into the jet. In low

  3. The effect of pore throat size and injection flowrate on the determination and sensitivity of different capillary number values at high-capillary-number flow in porous media

    NASA Astrophysics Data System (ADS)

    Yadali Jamaloei, Benyamin; Ahmadloo, Farid; Kharrat, Riyaz

    2010-10-01

    This study examines the effect of pore throat size and injection flowrate on the values of the pore-scale capillary number, the Newtonian-fluid capillary number and the apparent capillary number (Nc1, Nc2 and Nc3, respectively) and their sensitivity to change in high-capillary-number flow through porous media, which occurs in polymer-assisted dilute surfactant flooding (PADSF). Additionally, the influence of pore throat size and injection flowrate on oil recovery at breakthrough and at the end of displacement (ultimate) and the relationship between the effective shear rate γeff and the porous medium-dependent shift factor α are discussed. The results indicated that Nc2 was the smallest and Nc3 was the largest value. The difference between Nc2 and Nc3 is due to the increase in apparent viscosity of the polymer-contained surfactant solution during the flow through porous media and the change in Nc3 should be utilized to characterize the macroscopic behavior of the PADSF. Generally, the decrease in pore throat size and the increase in injection flowrate caused an increase in the ultimate oil recovery and Nc3. Moreover, the oil recovery at breakthrough decreased with an increase in pore throat size and injection flowrate. Finally, the rate of change of γeff, with change in α, increased almost uniformly with a decrease in pore throat size and an increase in injection flowrate.

  4. N-231 High Reynolds Number Channel Facility (An example of a Versatile Wind Tunnel) Tunnel 1 I is a

    NASA Technical Reports Server (NTRS)

    1980-01-01

    N-231 High Reynolds Number Channel Facility (An example of a Versatile Wind Tunnel) Tunnel 1 I is a blowdown Facility that utilizes interchangeable test sections and nozzles. The facility provides experimental support for the fluid mechanics research, including experimental verification of aerodynamic computer codes and boundary-layer and airfoil studies that require high Reynolds number simulation. (Tunnel 1)

  5. Ground Boundary Conditions for Thermal Convection Over Horizontal Surfaces at High Rayleigh Numbers

    NASA Astrophysics Data System (ADS)

    Hanjalić, K.; Hrebtov, M.

    2016-07-01

    We present "wall functions" for treating the ground boundary conditions in the computation of thermal convection over horizontal surfaces at high Rayleigh numbers using coarse numerical grids. The functions are formulated for an algebraic-flux model closed by transport equations for the turbulence kinetic energy, its dissipation rate and scalar variance, but could also be applied to other turbulence models. The three-equation algebraic-flux model, solved in a T-RANS mode ("Transient" Reynolds-averaged Navier-Stokes, based on triple decomposition), was shown earlier to reproduce well a number of generic buoyancy-driven flows over heated surfaces, albeit by integrating equations up to the wall. Here we show that by using a set of wall functions satisfactory results are found for the ensemble-averaged properties even on a very coarse computational grid. This is illustrated by the computations of the time evolution of a penetrative mixed layer and Rayleigh-Bénard (open-ended, 4:4:1 domain) convection, using 10 × 10 × 100 and 10 × 10 × 20 grids, compared also with finer grids (e.g. 60 × 60 × 100), as well as with one-dimensional treatment using 1 × 1 × 100 and 1 × 1 × 20 nodes. The approach is deemed functional for simulations of a convective boundary layer and mesoscale atmospheric flows, and pollutant transport over realistic complex hilly terrain with heat islands, urban and natural canopies, for diurnal cycles, or subjected to other time and space variations in ground conditions and stratification.

  6. Review of Skin Friction Measurements Including Recent High-Reynolds Number Results from NASA Langley NTF

    NASA Technical Reports Server (NTRS)

    Watson, Ralph D.; Hall, Robert M.; Anders, John B.

    2000-01-01

    This paper reviews flat plate skin friction data from early correlations of drag on plates in water to measurements in the cryogenic environment of The NASA Langley National Transonic Facility (NTF) in late 1996. The flat plate (zero pressure gradient with negligible surface curvature) incompressible skin friction at high Reynolds numbers is emphasized in this paper, due to its importance in assessing the accuracy of measurements, and as being important to the aerodynamics of large scale vehicles. A correlation of zero pressure gradient skin friction data minimizing extraneous effects between tests is often used as the first step in the calculation of skin friction in complex flows. Early data compiled by Schoenherr for a range of momentum thickness Reynolds numbers, R(sub Theta) from 860 to 370,000 contained large scatter, but has proved surprisingly accurate in its correlated form. Subsequent measurements in wind tunnels under more carefully controlled conditions have provided inputs to this database, usually to a maximum R(sub Theta) of about 40,000. Data on a large axisymmetric model in the NASA Langley National Transonic Facility extends the upper limit in incompressible R(sub Theta) to 619,800 using the van Driest transformation. Previous data, test techniques, and error sources ar discussed, and the NTF data will be discussed in detail. The NTF Preston tube and Clauser inferred data accuracy is estimated to be within -2 percent of a power-law curve fit, and falls above the Spalding theory by 1 percent at R(sub Theta) of about 600,000.

  7. Ground Boundary Conditions for Thermal Convection Over Horizontal Surfaces at High Rayleigh Numbers

    NASA Astrophysics Data System (ADS)

    Hanjalić, K.; Hrebtov, M.

    2016-02-01

    We present "wall functions" for treating the ground boundary conditions in the computation of thermal convection over horizontal surfaces at high Rayleigh numbers using coarse numerical grids. The functions are formulated for an algebraic-flux model closed by transport equations for the turbulence kinetic energy, its dissipation rate and scalar variance, but could also be applied to other turbulence models. The three-equation algebraic-flux model, solved in a T-RANS mode ("Transient" Reynolds-averaged Navier-Stokes, based on triple decomposition), was shown earlier to reproduce well a number of generic buoyancy-driven flows over heated surfaces, albeit by integrating equations up to the wall. Here we show that by using a set of wall functions satisfactory results are found for the ensemble-averaged properties even on a very coarse computational grid. This is illustrated by the computations of the time evolution of a penetrative mixed layer and Rayleigh-Bénard (open-ended, 4:4:1 domain) convection, using 10 × 10 × 100 and 10 × 10 × 20 grids, compared also with finer grids (e.g. 60 × 60 × 100 ), as well as with one-dimensional treatment using 1 × 1 × 100 and 1 × 1 × 20 nodes. The approach is deemed functional for simulations of a convective boundary layer and mesoscale atmospheric flows, and pollutant transport over realistic complex hilly terrain with heat islands, urban and natural canopies, for diurnal cycles, or subjected to other time and space variations in ground conditions and stratification.

  8. Numerical aspects in modeling high Deborah number flow and elastic instability

    NASA Astrophysics Data System (ADS)

    Kwon, Youngdon

    2014-05-01

    Investigating highly nonlinear viscoelastic flow in 2D domain, we explore problem as well as property possibly inherent in the streamline upwinding technique (SUPG) and then present various results of elastic instability. The mathematically stable Leonov model written in tensor-logarithmic formulation is employed in the framework of finite element method for spatial discretization of several representative problem domains. For enhancement of computation speed, decoupled integration scheme is applied for shear thinning and Boger-type fluids. From the analysis of 4:1 contraction flow at low and moderate values of the Deborah number (De) the solution with SUPG method does not show noticeable difference from the one by the computation without upwinding. On the other hand, in the flow regime of high De, especially in the state of elastic instability the SUPG significantly distorts the flow field and the result differs considerably from the solution acquired straightforwardly. When the strength of elastic flow and thus the nonlinearity further increase, the computational scheme with upwinding fails to converge and evolutionary solution does not become available any more. All this result suggests that extreme care has to be taken on occasions where upwinding is applied, and one has to first of all prove validity of this algorithm in the case of high nonlinearity. On the contrary, the straightforward computation with no upwinding can efficiently model representative phenomena of elastic instability in such benchmark problems as 4:1 contraction flow, flow over a circular cylinder and flow over asymmetric array of cylinders. Asymmetry of the flow field occurring in the symmetric domain, enhanced spatial and temporal fluctuation of dynamic variables and flow effects caused by extension hardening are properly described in this study.

  9. Experimental Research on Heat Transfer Enhancement for High Prandtl-Number Fluid

    SciTech Connect

    Chiba, Shin-ya; Omae, Masahiro; Yuki, Kazuhisa; Hashizume, Hidetoshi; Toda, Saburo; Sagara, Akio

    2005-04-15

    The experimental research on heat-transfer enhancement for such high Prandtl-number fluid as Flibe has been performed with a large molten salt circulating experimental loop named as 'TNT loop' (Tohoku-NIFS Thermofluid loop). Through the experiments, a packed-bed tube is employed as the enhancer for molten salt. It is clarified that the enhancement of packed-bed tube is superior to that of turbulent heat transfer from the viewpoint of the same flow rate. Also, the 1/4-diameter bed is superior to the 1/2-diameter one at the same flow rate. Furthermore, at low flow rate, a little differences of heat transfer performance can be seen between the stainless-steel bed and copper bed. At high flow rate, however, the heat-transfer coefficient ratio strongly depends on the flow rate in the case of the 1/4-diameter copper bed only. As a result, it is considered that the thermal energy is expanded from a heated wall deeply and fast through packed bed at low flow rate. On the contrary, it is also considered that the convective heat transfer in the vicinity of a heated wall is strong at high flow rate. The evaluation from the viewpoint of the pressure drop shows that the turbulent heat transfer is superior to that with packed bed. However, the ratio of heat transfer with bed to turbulent one is steeply improved at low flow rate. Taking account of MHD effect, avoidance of erosion and electrolysis of Flibe, the enhancement under low flow-rate condition can be suitable in a fusion reactor.

  10. High natural killer cell number might identify stroke patients at risk of developing infections

    PubMed Central

    De Vos, Aurelie; Van Binst, Anne-Marie; De Waele, Marc; Coomans, Danny; Buyl, Ronald; De Keyser, Jacques

    2015-01-01

    Objective: To investigate early changes in leukocyte subsets and autonomic function as predictors of the development of poststroke infections. Methods: We assessed the time course of leukocyte subsets in the blood of 59 patients with acute ischemic stroke. We divided the patients into 2 groups: those who developed infections during the first 7 days after stroke onset and those who did not. We measured urinary norepinephrine and epinephrine concentrations and pulse rate variability indices within 24 hours of admission. Results: We found that the number of circulating natural killer (NK) cells within the first hours after stroke was higher in stroke patients who developed infections (mean 435 cells/mL; 95% confidence interval [CI] 321–588) than in stroke patients who did not develop infections (mean 236 cells/mL; 95% CI 186–300; p = 0.001). This was followed by a decrease in all lymphocyte subsets from admission to day 1, varying between 22% and 40%, which was not seen in patients without poststroke infection (mean increase varied between 2% and 23%; all p < 0.005). In the group that developed infections, pulse rate variability revealed a decreased high frequency component. These findings all remained significant after adjustment for age and stroke volume. Conclusions: High circulating NK cell count within the first hours after ischemic stroke onset followed by a drop in all lymphocyte subsets identified patients who developed infections and may be caused by a sympathovagal imbalance with sympathetic overweight. These findings need to be validated in larger studies. PMID:25738168

  11. Post-translationally Abnormal Collagens of Prolyl 3-Hydroxylase-2 Null Mice Offer a Pathobiological Mechanism for the High Myopia Linked to Human LEPREL1 Mutations*

    PubMed Central

    Hudson, David M.; Joeng, Kyu Sang; Werther, Rachel; Rajagopal, Abbhirami; Weis, MaryAnn; Lee, Brendan H.; Eyre, David R.

    2015-01-01

    Myopia, the leading cause of visual impairment worldwide, results from an increase in the axial length of the eyeball. Mutations in LEPREL1, the gene encoding prolyl 3-hydroxylase-2 (P3H2), have recently been identified in individuals with recessively inherited nonsyndromic severe myopia. P3H2 is a member of a family of genes that includes three isoenzymes of prolyl 3-hydroxylase (P3H), P3H1, P3H2, and P3H3. Fundamentally, it is understood that P3H1 is responsible for converting proline to 3-hydroxyproline. This limited additional knowledge also suggests that each isoenzyme has evolved different collagen sequence-preferred substrate specificities. In this study, differences in prolyl 3-hydroxylation were screened in eye tissues from P3h2-null (P3h2n/n) and wild-type mice to seek tissue-specific effects due the lack of P3H2 activity on post-translational collagen chemistry that could explain myopia. The mice were viable and had no gross musculoskeletal phenotypes. Tissues from sclera and cornea (type I collagen) and lens capsule (type IV collagen) were dissected from mouse eyes, and multiple sites of prolyl 3-hydroxylation were identified by mass spectrometry. The level of prolyl 3-hydroxylation at multiple substrate sites from type I collagen chains was high in sclera, similar to tendon. Almost every known site of prolyl 3-hydroxylation in types I and IV collagen from P3h2n/n mouse eye tissues was significantly under-hydroxylated compared with their wild-type littermates. We conclude that altered collagen prolyl 3-hydroxylation is caused by loss of P3H2. We hypothesize that this leads to structural abnormalities in multiple eye tissues, but particularly sclera, causing progressive myopia. PMID:25645914

  12. Linear global modes in a high Reynolds number Mach 0.9 turbulent jet

    NASA Astrophysics Data System (ADS)

    Schmidt, Oliver; Towne, Aaron; Colonius, Tim

    2015-11-01

    A global linear stability and resolvent analysis of the mean flow from a carefully validated Mach 0 . 9 turbulent jet large eddy simulation (LES) is conducted. Spatiotemporal Fourier decomposition of the simulation data reveals the presence of large scale coherent structures at small azimuthal wavenumbers. The latter wave packets appear as discrete sets of lightly dampened modes in the linear global stability analysis. Their common feature is a spatial separation into an upstream traveling acoustic perturbation in the potential core region, and a Kelvin-Helmholtz-like vortical perturbation which is advected downstream. The least stable branch of discrete modes observed at Strouhal numbers 0 . 38 < St < 0 . 42 exhibits the same acoustic super-directivity as found in the LES and various experimental studies, and hence establishes a direct link between global linear instabilities and low-angle acoustic radiation. Branches at higher frequencies and azimuthal wavenumbers show multi-directive acoustic emission patterns. This observation is of particular interest since high angle, broadband radiation is commonly attributed to stochastic fluctuations of the turbulent jet shear layer.

  13. Flocculation model and collision potential for reactors with flows characterized by high Peclet numbers.

    PubMed

    Weber-Shirk, Monroe L; Lion, Leonard W

    2010-10-01

    A mechanistically-based model is developed to characterize flocculation in the context of flow regimes with high Peclet numbers such as would occur in serpentine flow reactors. These flow conditions are obtained in gravity-driven hydraulic flocculators without mechanical agitation that are an important component of sustainable water treatment systems where energy efficiency and cost are receiving increasing emphasis. The model incorporates a fractal description of flocs, estimates of floc separation distances, estimates of relative velocities of floc particles dependent on the relevant flow regime, and provides an overall prediction of the required reaction time for formation of settleable flocs based on influent turbidity, alum dose, and energy dissipation rate. Viscosity is shown to be significant for the early stage of flocculation and turbulent eddies are shown to be significant for the final stage of flocculation. The collision potential defined as the product of the hydraulic residence time (θ) and the cube root of the energy dissipation rate (ɛ), i.e., ɛ(1/3)θ, is shown to be a better predictor of flocculator performance than the conventional product of θ and the velocity gradient (G), i.e., Gθ. PMID:20605037

  14. A High-Resolution Copy Number Variation Resource for Clinical and Population Genetics

    PubMed Central

    Uddin, Mohammed; Thiruvahindrapuram, Bhooma; Walker, Susan; Wang, Zhuozhi; Hu, Pingzhao; Lamoureux, Sylvia; Wei, John; MacDonald, Jeffrey R.; Pellecchia, Giovanna; Lu, Chao; Lionel, Anath C.; Gazzellone, Matthew J.; McLaughlin, John R.; Brown, Catherine; Andrulis, Irene L.; Knight, Julia A.; Herbrick, Jo-Anne; Wintle, Richard F.; Ray, Peter; Stavropoulos, Dimitri J.; Marshall, Christian R.; Scherer, Stephen W.

    2016-01-01

    Purpose Chromosomal microarray analysis to assess copy number variation (CNV) has become a first tier genetic diagnostic test for individuals with unexplained neurodevelopmental disorders (NDD) or multiple congenital anomalies (MCA). Over 100 cytogenetic labs worldwide use the new ultra-high resolution Affymetrix CytoScan-HD array to genotype hundreds of thousands of samples per year. Our aim was to develop a CNV resource from a new population sample, which would enable more accurate interpretation of clinical genetics data on this microarray platform, and others. Methods Genotyping of 1,000 adult volunteers who are broadly representative of the Ontario population (as obtained from the Ontario Population Genomics Platform) was performed with the CytoScan-HD microarray system, which has 2.7 million probes. Four independent algorithms were applied to detect CNVs. Reproducibility and validation metrics were quantified using sample replicates and quantitative-PCR, respectively. Results DNA from 873 individuals passed quality control and we identified 71,178 CNVs (81 CNVs/individual); 9.8% (6,984) of these CNVs were previously unreported. After applying three layers of filtering criteria, from our highest confidence CNVs dataset we obtained >95% reproducibility and >90% validation rate (73% of these CNVs overlapped at least one gene). Conclusion The genotype data and annotated CNVs for this largely Caucasian population will represent a valuable public resource enabling clinical genetics research and diagnostics. PMID:25503493

  15. The effect of tip speed ratio on a vertical axis wind turbine at high Reynolds numbers

    NASA Astrophysics Data System (ADS)

    Parker, Colin M.; Leftwich, Megan C.

    2016-05-01

    This work visualizes the flow surrounding a scaled model vertical axis wind turbine at realistic operating conditions. The model closely matches geometric and dynamic properties—tip speed ratio and Reynolds number—of a full-size turbine. The flow is visualized using particle imaging velocimetry (PIV) in the midplane upstream, around, and after (up to 4 turbine diameters downstream) the turbine, as well as a vertical plane behind the turbine. Time-averaged results show an asymmetric wake behind the turbine, regardless of tip speed ratio, with a larger velocity deficit for a higher tip speed ratio. For the higher tip speed ratio, an area of averaged flow reversal is present with a maximum reverse flow of -0.04U_∞. Phase-averaged vorticity fields—achieved by syncing the PIV system with the rotation of the turbine—show distinct structures form from each turbine blade. There were distinct differences in results by tip speed ratios of 0.9, 1.3, and 2.2 of when in the cycle structures are shed into the wake—switching from two pairs to a single pair of vortices being shed—and how they convect into the wake—the middle tip speed ratio vortices convect downstream inside the wake, while the high tip speed ratio pair is shed into the shear layer of the wake. Finally, results show that the wake structure is much more sensitive to changes in tip speed ratio than to changes in Reynolds number.

  16. Using Computational Fluid Dynamics and Experiments to Design Sweeping Jets for High Reynolds Number Cruise Configurations

    NASA Technical Reports Server (NTRS)

    Jones, Gregory S.; Milholen, William E., II; Fell, Jared S.; Webb, Sandy R.; Cagle, C. Mark

    2016-01-01

    The application of a sweeping jet actuator to a circulation control system was initiated by a risk reduction series of experiments to optimize the authority of a single sweeping jet actuator. The sweeping jet design was integrated into the existing Fundamental Aerodynamic Subsonic Transonic- Modular Active Control (FAST-MAC) model by replacing the steady blowing system with an array of thirty-nine sweeping jet cartridges. A constant slot height to wing chord ratio was similar to the steady blowing configuration resulting in each actuator having a unique in size for the sweeping jet configuration. While this paper will describe the scaling and optimization of the actuators for future high Reynolds number applications, the major focus of this effort was to target the transonic flight regime by increasing the amplitude authority of the actuator. This was accomplished by modifying the diffuser of the sweeping jet actuator, and this paper highlights twelve different diffuser designs. The experimental portion of this work was completed in the NASA Langley National Transonic Facility.

  17. Laboratory Study of Homogeneous and Isotropic Turbulence at High Reynolds Number

    NASA Astrophysics Data System (ADS)

    Pecenak, Zachary; Dou, Zhongwang; Yang, Fan; Cao, Lujie; Liang, Zach; Meng, Hui

    2013-11-01

    To study particle dynamics modified by isotropic turbulence at high Reynolds numbers and provide experimental data for DNS validation, we have developed a soccer-ball-shaped truncated icosahedron turbulence chamber with 20 adjoining hexagon surfaces, 12 pentagon surfaces and twenty symettrically displaced fans, which form an enclosed chamber of 1m diameter. We use Particle Image Velocimetry (PIV) technique to characterize the base turbulent flow, using different PIV set ups to capture various characteristic scales of turbulence. Results show that the stationary isotropic turbulence field is a spherical domain with diameter of 40 mm with quasi-zero mean velocities. The maximum rms velocity is ~1.5 m/s, corresponding to a Taylor microscale Re of 450. We extract from the PIV velocity field the whole set of turbulent flow parameters including: turbulent kinetic energy, turbulent intensity, kinetic energy dissipation rate, large eddy length and time scales, the Kolmogorov length, time and velocity scales, Taylor microscale and Re, which are critical to the study of inter-particle statistics modified by turbulence. This research is funded by an NSF grant CBET-0967407.

  18. Magnetic characteristics of a high-layer-number NiFe/FeMn multilayer

    NASA Astrophysics Data System (ADS)

    Paterson, G. W.; Gonçalves, F. J. T.; McFadzean, S.; O'Reilly, S.; Bowman, R.; Stamps, R. L.

    2015-11-01

    We report the static and dynamic magnetic characteristics of a high-layer-number NiFe/FeMn multilayer test structure with potential applications in broadband absorber and filter devices. To allow fine control over the absorption linewidths and to understand the mechanisms governing the resonances in a tailored structure similar to that expected to be used in real world applications, the multilayer was intentionally designed to have layer thickness and interface roughness variations. Magnetometry measurements show that the sample has complex hysteresis loops with features consistent with single ferromagnetic film reversals. Characterisation by transmission electron microscopy allows us to correlate the magnetic properties with structural features, including the film widths and interface roughnesses. Analysis of resonance frequencies from broadband ferromagnetic resonance measurements as a function of field magnitude and orientation provide values of the local exchange bias, rotatable anisotropy, and uniaxial anisotropy fields for specific layers in the stack and explain the observed mode softening. The linewidths of the multilayer are adjustable around the bias field, approaching twice that seen at larger fields, allowing control over the bandwidth of devices formed from the structure.

  19. Critical analysis of high particle number emissions from accelerating compressed natural gas buses.

    PubMed

    Jayaratne, E R; Meyer, N K; Ristovski, Z D; Morawska, L; Miljevic, B

    2010-05-15

    Compressed natural gas (CNG) engines are thought to be less harmful to the environment than conventional diesel engines, especially in terms of particle emissions. Although, this is true with respect to particulate matter (PM) emissions, results of particle number (PN) emission comparisons have been inconclusive. In this study, results of on-road and dynamometer studies of buses were used to derive several important conclusions. We show that, although PN emissions from CNG buses are significantly lower than from diesel buses at low engine power, they become comparable at high power. For diesel buses, PN emissions are not significantly different between acceleration and operation at steady maximum power. However, the corresponding PN emissions from CNG buses when accelerating are an order of magnitude greater than when operating at steady maximum power. During acceleration under heavy load, PN emissions from CNG buses are an order of magnitude higher than from diesel buses. The particles emitted from CNG buses are too small to contribute to PM(10) emissions or contribute to a reduction of visibility and may consist of semivolatile nanoparticles. PMID:20384333

  20. High Rayleigh Number 3-D Spherical Mantle Convection with Radial Basis Functions

    NASA Astrophysics Data System (ADS)

    Flyer, N.; Yuen (3), G. Wright, D.

    2009-04-01

    In the last quarter of a century many numerical methods, such as finite-differences, finite-volume, their yin-yang variants, finite-elements and pseudo-spectral methods have been used to study the problem of 3-D spherical convection. All have their respective strengths but also serious weaknesses, such as low-order and can involve high algorithmic complexity, as in triangular elements. Spectrally accurate methods do not practically allow for local mesh refinement and often involve cumbersome algebra. We have recently introduced a new grid/mesh-free approach, using radial basis functions ( RBFs) . It has the advantage of being spectrally accurate for arbitrary node layouts in multi-dimensions with extreme algorithmic simplicity, and allows naturally node-refinement. One virtue of the RBF scheme is the ability to use a simple Cartesian geometry while implementing the required boundary conditions for the temperature, velocity and stresses on a spherical surface of both the outer( planetary surface ) and inner shell ( core-mantle boundary ). The velocity and stress components are expressed in terms of the scalar potential approach and the other remaining variable is the perturbed temperature field. We have studied the problem from the weakly nonlinear to a moderately nonlinear regime involving a Rayleigh number, about 1000 times super-critical. Both purely basal and partially internal -heating cases have been considered

  1. High Rayleigh Number 3-D Spherical Mantle Convection with Radial Basis Functions

    NASA Astrophysics Data System (ADS)

    Flyer, N.; Wright, G.; Yuen, D. A.

    2009-04-01

    In the last quarter of a century many numerical methods, such as finite-differences, finite-volume, their yin-yang variants, finite-elements and pseudo-spectral methods have been used to study the problem of 3-D spherical convection. All have their respective strengths but also serious weaknesses, such as low-order and can involve high algorithmic complexity, as in triangular elements. Spectrally accurate methods do not practically allow for local mesh refinement and often involve cumbersome algebra. We have recently introduced a new grid/mesh-free approach, using radial basis functions (RBFs). It has the advantage of being spectrally accurate for arbitrary node layouts in multi-dimensions with extreme algorithmic simplicity, and allows naturally node-refinement. One virtue of the RBF scheme is the ability to use a simple Cartesian geometry while implementing the required boundary conditions for the temperature, velocity and stresses on a spherical surface of both the outer(planetary surface) and inner shell (core-mantle boundary). The velocity and stress components are expressed in terms of the scalar potential approach and the other remaining variable is the perturbed temperature field. We have studied the problem from the weakly onlinear to a moderately nonlinear regime involving a Rayleigh number, about 1000 times super-critical. Both purely basal and partially internal-heating cases have been considered.

  2. Dynamic non-equilibrium wall-modeling for large eddy simulation at high Reynolds numbers

    NASA Astrophysics Data System (ADS)

    Kawai, Soshi; Larsson, Johan

    2013-01-01

    A dynamic non-equilibrium wall-model for large-eddy simulation at arbitrarily high Reynolds numbers is proposed and validated on equilibrium boundary layers and a non-equilibrium shock/boundary-layer interaction problem. The proposed method builds on the prior non-equilibrium wall-models of Balaras et al. [AIAA J. 34, 1111-1119 (1996)], 10.2514/3.13200 and Wang and Moin [Phys. Fluids 14, 2043-2051 (2002)], 10.1063/1.1476668: the failure of these wall-models to accurately predict the skin friction in equilibrium boundary layers is shown and analyzed, and an improved wall-model that solves this issue is proposed. The improvement stems directly from reasoning about how the turbulence length scale changes with wall distance in the inertial sublayer, the grid resolution, and the resolution-characteristics of numerical methods. The proposed model yields accurate resolved turbulence, both in terms of structure and statistics for both the equilibrium and non-equilibrium flows without the use of ad hoc corrections. Crucially, the model accurately predicts the skin friction, something that existing non-equilibrium wall-models fail to do robustly.

  3. Magnetic characteristics of a high-layer-number NiFe/FeMn multilayer

    SciTech Connect

    Paterson, G. W. Gonçalves, F. J. T.; McFadzean, S.; Stamps, R. L.; O'Reilly, S.; Bowman, R.

    2015-11-28

    We report the static and dynamic magnetic characteristics of a high-layer-number NiFe/FeMn multilayer test structure with potential applications in broadband absorber and filter devices. To allow fine control over the absorption linewidths and to understand the mechanisms governing the resonances in a tailored structure similar to that expected to be used in real world applications, the multilayer was intentionally designed to have layer thickness and interface roughness variations. Magnetometry measurements show that the sample has complex hysteresis loops with features consistent with single ferromagnetic film reversals. Characterisation by transmission electron microscopy allows us to correlate the magnetic properties with structural features, including the film widths and interface roughnesses. Analysis of resonance frequencies from broadband ferromagnetic resonance measurements as a function of field magnitude and orientation provide values of the local exchange bias, rotatable anisotropy, and uniaxial anisotropy fields for specific layers in the stack and explain the observed mode softening. The linewidths of the multilayer are adjustable around the bias field, approaching twice that seen at larger fields, allowing control over the bandwidth of devices formed from the structure.

  4. Linear drag law for high-Reynolds-number flow past an oscillating body

    NASA Astrophysics Data System (ADS)

    Agre, Natalie; Childress, Stephen; Zhang, Jun; Ristroph, Leif

    2016-07-01

    An object immersed in a fast flow typically experiences fluid forces that increase with the square of speed. Here we explore how this high-Reynolds-number force-speed relationship is affected by unsteady motions of a body. Experiments on disks that are driven to oscillate while progressing through air reveal two distinct regimes: a conventional quadratic relationship for slow oscillations and an anomalous scaling for fast flapping in which the time-averaged drag increases linearly with flow speed. In the linear regime, flow visualization shows that a pair of counterrotating vortices is shed with each oscillation and a model that views a train of such dipoles as a momentum jet reproduces the linearity. We also show that appropriate scaling variables collapse the experimental data from both regimes and for different oscillatory motions into a single drag-speed relationship. These results could provide insight into the aerodynamic resistance incurred by oscillating wings in flight and they suggest that vibrations can be an effective means to actively control the drag on an object.

  5. High-Throughput Droplet Digital PCR System for Absolute Quantitation of DNA Copy Number

    PubMed Central

    2011-01-01

    Digital PCR enables the absolute quantitation of nucleic acids in a sample. The lack of scalable and practical technologies for digital PCR implementation has hampered the widespread adoption of this inherently powerful technique. Here we describe a high-throughput droplet digital PCR (ddPCR) system that enables processing of ∼2 million PCR reactions using conventional TaqMan assays with a 96-well plate workflow. Three applications demonstrate that the massive partitioning afforded by our ddPCR system provides orders of magnitude more precision and sensitivity than real-time PCR. First, we show the accurate measurement of germline copy number variation. Second, for rare alleles, we show sensitive detection of mutant DNA in a 100 000-fold excess of wildtype background. Third, we demonstrate absolute quantitation of circulating fetal and maternal DNA from cell-free plasma. We anticipate this ddPCR system will allow researchers to explore complex genetic landscapes, discover and validate new disease associations, and define a new era of molecular diagnostics. PMID:22035192

  6. MHC variability supports dog domestication from a large number of wolves: high diversity in Asia

    PubMed Central

    Niskanen, A K; Hagström, E; Lohi, H; Ruokonen, M; Esparza-Salas, R; Aspi, J; Savolainen, P

    2013-01-01

    The process of dog domestication is still somewhat unresolved. Earlier studies indicate that domestic dogs from all over the world have a common origin in Asia. So far, major histocompatibility complex (MHC) diversity has not been studied in detail in Asian dogs, although high levels of genetic diversity are expected at the domestication locality. We sequenced the second exon of the canine MHC gene DLA–DRB1 from 128 Asian dogs and compared our data with a previously published large data set of MHC alleles, mostly from European dogs. Our results show that Asian dogs have a higher MHC diversity than European dogs. We also estimated that there is only a small probability that new alleles have arisen by mutation since domestication. Based on the assumption that all of the currently known 102 DLA–DRB1 alleles come from the founding wolf population, we simulated the number of founding wolf individuals. Our simulations indicate an effective population size of at least 500 founding wolves, suggesting that the founding wolf population was large or that backcrossing has taken place. PMID:23073392

  7. Origin of high particle number concentrations reaching the St. Louis, Midwest Supersite.

    PubMed

    de Foy, Benjamin; Schauer, James J

    2015-08-01

    Ultrafine particles are associated with adverse health effects. Total Particle Number Concentration (TNC) of fine particles were measured during 2002 at the St. Louis - Midwest supersite. The time series showed overall low level with frequent large peaks. The time series was analyzed alongside criteria pollutant measurements and meteorological observations. Multiple regression analysis was used to identify further contributing factors and to determine the association of different pollutants with TNC levels. This showed the strong contribution of sulfur dioxide (SO2) and nitrogen oxides (NOx) to high TNC levels. The analysis also suggested that increased dispersion resulting from faster winds and higher mixing heights led to higher TNC levels. Overall, the results show that there were intense particle nucleation events in a SO2 rich plume reaching the site which contributed around 29% of TNC. A further 40% was associated with primary emissions from mobile sources. By separating the remaining TNC by time of day and clear sky conditions, we suggest that most likely 8% of TNC are due to regional nucleation events and 23% are associated with the general urban background. PMID:26257365

  8. Clinical abnormalities in working donkeys and their associations with behaviour

    PubMed Central

    Regan (nee Ashley), F. H.; Hockenhull, J.; Pritchard, J. C.; Waterman-Pearson, A. E.; Whay, H. R.

    2015-01-01

    Introductions Working donkeys are at risk of developing multiple, acute and chronic health problems. The ability to recognise and assess pain in donkeys associated with these health problems is important for people responsible for their care and treatment, including owners and veterinary or animal health workers. Aims and objectives The aims of this study were firstly to quantify the prevalence of a range of clinical abnormalities within a sample of working donkeys; and secondly to find out whether these abnormalities were associated with potential behavioural indicators of pain. Materials and methods One hundred and thirty-three entire male adult working donkeys were observed for ten minutes before and after a one-hour rest period. Using an ethogram developed and refined in associated studies, posture and event behaviours were recorded by a single observer. The health of each donkey was then assessed by a veterinarian for specific clinical abnormalities. Results Working donkeys have a high prevalence of clinical abnormalities and a number of behaviours are associated with these. Significant associations were found between observed behaviours and systemic, ocular and limb-related clinical abnormalities. Cumulative clinical scores for limb-related problems were associated with a higher frequency of leg trembling, knuckling of the forelimb, leg-lifting and weight-shifting behaviours (all R≥0.4; P<0.001) and with a lower frequency of weight-bearing evenly on all four feet (R=-0.458; P<0.001). Conclusions The specific behaviour changes associated with clinical abnormalities identified in this study, together with general changes in demeanour identified in related studies, may be useful in assessing the presence and severity of pain in working donkeys and their response to medical and palliative interventions. PMID:26392903

  9. Application of a Planar Doppler Velocimetry System to a High Reynolds Number Compressible Jet

    NASA Technical Reports Server (NTRS)

    Smith, Michael W.

    1998-01-01

    A Planar Doppler Velocimetry (PDV) system has been constructed and used to investigate the instantaneous turbulent velocity structure of a round high-speed compressible air jet with a low-speed co-flow. The exit condition was Mach=0.85 at ambient pressure, yielding a Reynolds number of about 650,000 on diameter. The PDV system was installed at NASA Langley Research Center in the Small Anechoic Jet Facility (SAJF), a chamber in which both the acoustic and aerodynamic properties of jets can be studied. For this test, the goal was to gather data which can be used to relate the turbulence structure of the jet to the levels and character of the acoustic noise produced by the jet. The current PDV system can acquire single-velocity-component, single-shot, planar images (15ns exposures) at 30 Hz. For this paper, the primary data set consists of 240 frames of velocity data acquired with both the jet and the low-speed co-flow seeded with light-scattering articles. Thus, velocities could be measured everywhere in the jet shear layer, both in the jet fluid and in the entrained co-flow. Some data were also taken with only the jet flow seeded. These provided mixing concentration images along with the reduced velocity fields. Other images were taken with only the co-flow seeded. These produced unique quantitative images of high speed entrainment. Optical "laser speckle" noise is the largest source of random noise in pulsed PDV systems. Components for the PDV imaging system were specifically selected to minimize speckle noise. To reduce systematic velocity errors due to laser drift, a frequency monitoring reference leg with a temperature-tuned reference iodine cell, was employed. In the course of this study, a novel flow seeder was developed. It enabled continuously variable seeding of the flow with particles of Sheared Pyrogenic Amorphous Hydrophobic Silica (SPAHS). The seeder comprised a dry fluidized bed hopper and a supersonic nozzle "pickup." Shearing action in the pickup

  10. Unsteady pressure measurements on a supercritical airfoil at high Reynolds numbers

    NASA Technical Reports Server (NTRS)

    Hess, R. W.

    1989-01-01

    Steady and unsteady pressures were measured on a 14 percent supercritical airfoil at transonic Mach numbers at Reynolds numbers from 6,000,000 to 35,000,000. Instrumentation techniques were developed to measure unsteady pressures in a cryogenic tunnel at flight Reynolds numbers. Experimental steady data, corrected for wall effects show very good agreement with calculations from a full potential code with an interacted boundary layer. The steady and unsteady pressures both show a shock position that is dependent on Reynolds number. For a supercritical pressure distribution at a chord Reynolds number of 35,000,000 laminar flow was observed between the leading edge and the shock wave at 45 percent chord.

  11. Pressure recovery performance of conical diffusers at high subsonic Mach numbers

    NASA Technical Reports Server (NTRS)

    Dolan, F. X.; Runstadler, P. W., Jr.

    1973-01-01

    The pressure recovery performance of conical diffusers has been measured for a wide range of geometries and inlet flow conditions. The approximate level and location (in terms of diffuser geometry of optimum performance were determined. Throat Mach numbers from low subsonic (m sub t equals 0.2) through choking (m sub t equals 1.0) were investigated in combination with throat blockage from 0.03 to 0.12. For fixed Mach number, performance was measured over a fourfold range of inlet Reynolds number. Maps of pressure recovery are presented as a function of diffuser geometry for fixed sets of inlet conditions. The influence of inlet blockage, throat Mach number, and inlet Reynolds number is discussed.

  12. Abnormal myocardial perfusion and risk of heart failure in patients with type 2 diabetes mellitus

    PubMed Central

    Utrera-Lagunas, Marcelo; Orea-Tejeda, Arturo; Castillo-Martínez, Lilia; Balderas-Muñoz, Karla; Keirns-Davis, Candace; Espinoza-Rosas, Sarahi; Sánchez-Ortíz, Néstor Alonso; Olvera-Mayorga, Gabriela

    2013-01-01

    BACKGROUND: Diabetes is a major risk factor for heart failure (HF), although the pathophysiological processes have not been clarified. OBJECTIVE: To determine the prevalence of HF and of abnormal myocardial perfusion in diabetic patients evaluated using technetium (99m) sestamibi single-photon emission computed tomography. METHODS: An observational cross-sectional study was conducted that included patients with type 2 diabetes mellitus who underwent echocardiography to diagnose HF and a pharmacological stress test with intravenous dipyridamole to examine cardiac scintigraphic perfusion abnormalities. Clinical and biochemical data were also collected. RESULTS: Of the 160 diabetic patients included, 92 (57.6%) were in HF and 68 (42.5%) were not. When patients were stratified according to the presence of abnormal myocardial perfusion, those with abnormal perfusion had a higher prevalence of HF (93%) than those with normal perfusion (44.4%) (P<0.0001). Patients with HF weighed more (P=0.03), used insulin less frequently (P=0.01), had lower total cholesterol (P=0.05) and high-density lipoprotein cholesterol concentrations (P=0.002), and a greater number of their myocardial segments showed abnormal perfusion (P≤0.001). More HF patients had a history of myocardial infarction (P<0.001) compared with those without HF. In a logistic regression analysis, the number of segments exhibiting abnormal myocardial perfusion was an independent risk factor for HF. CONCLUSIONS: The prevalence of HF in diabetic patients was high and HF predominantly occured in association with myocardial ischemia. PMID:24294048

  13. Measurements of fluctuating pressure in a rectangular cavity in transonic flow at high Reynolds numbers

    NASA Technical Reports Server (NTRS)

    Tracy, M. B.; Plentovich, E. B.; Chu, Julio

    1992-01-01

    An experiment was performed in the Langley 0.3 meter Transonic Cryogenic Tunnel to study the internal acoustic field generated by rectangular cavities in transonic and subsonic flows and to determine the effect of Reynolds number and angle of yaw on the field. The cavity was 11.25 in. long and 2.50 in. wide. The cavity depth was varied to obtain length-to-height (l/h) ratios of 4.40, 6.70, 12.67, and 20.00. Data were obtained for a free stream Mach number range from 0.20 to 0.90, a Reynolds number range from 2 x 10(exp 6) to 100 x 10(exp 6) per foot with a nearly constant boundary layer thickness, and for two angles of yaw of 0 and 15 degs. Results show that Reynolds number has little effect on the acoustic field in rectangular cavities at angle of yaw of 0 deg. Cavities with l/h = 4.40 and 6.70 generated tones at transonic speeds, whereas those with l/h = 20.00 did not. This trend agrees with data obtained previously at supersonic speeds. As Mach number decreased, the amplitude, and bandwidth of the tones changed. No tones appeared for Mach number = 0.20. For a cavity with l/h = 12.67, tones appeared at Mach number = 0.60, indicating a possible change in flow field type. Changes in acoustic spectra with angle of yaw varied with Reynolds number, Mach number, l/h ratios, and acoustic mode number.

  14. On the Formation Mechanisms of Artificially Generated High Reynolds Number Turbulent Boundary Layers

    NASA Astrophysics Data System (ADS)

    Rodríguez-López, Eduardo; Bruce, Paul J. K.; Buxton, Oliver R. H.

    2016-08-01

    We investigate the evolution of an artificially thick turbulent boundary layer generated by two families of small obstacles (divided into uniform and non-uniform wall normal distributions of blockage). One- and two-point velocity measurements using constant temperature anemometry show that the canonical behaviour of a boundary layer is recovered after an adaptation region downstream of the trips presenting 150~% higher momentum thickness (or equivalently, Reynolds number) than the natural case for the same downstream distance (x≈ 3 m). The effect of the degree of immersion of the trips for h/δ ≳ 1 is shown to play a secondary role. The one-point diagnostic quantities used to assess the degree of recovery of the canonical properties are the friction coefficient (representative of the inner motions), the shape factor and wake parameter (representative of the wake regions); they provide a severe test to be applied to artificially generated boundary layers. Simultaneous two-point velocity measurements of both spanwise and wall-normal correlations and the modulation of inner velocity by the outer structures show that there are two different formation mechanisms for the boundary layer. The trips with high aspect ratio and uniform distributed blockage leave the inner motions of the boundary layer relatively undisturbed, which subsequently drive the mixing of the obstacles' wake with the wall-bounded flow (wall-driven). In contrast, the low aspect-ratio trips with non-uniform blockage destroy the inner structures, which are then re-formed further downstream under the influence of the wake of the trips (wake-driven).

  15. On the Formation Mechanisms of Artificially Generated High Reynolds Number Turbulent Boundary Layers

    NASA Astrophysics Data System (ADS)

    Rodríguez-López, Eduardo; Bruce, Paul J. K.; Buxton, Oliver R. H.

    2016-03-01

    We investigate the evolution of an artificially thick turbulent boundary layer generated by two families of small obstacles (divided into uniform and non-uniform wall normal distributions of blockage). One- and two-point velocity measurements using constant temperature anemometry show that the canonical behaviour of a boundary layer is recovered after an adaptation region downstream of the trips presenting 150~% higher momentum thickness (or equivalently, Reynolds number) than the natural case for the same downstream distance (x≈ 3 m). The effect of the degree of immersion of the trips for h/δ ≳ 1 is shown to play a secondary role. The one-point diagnostic quantities used to assess the degree of recovery of the canonical properties are the friction coefficient (representative of the inner motions), the shape factor and wake parameter (representative of the wake regions); they provide a severe test to be applied to artificially generated boundary layers. Simultaneous two-point velocity measurements of both spanwise and wall-normal correlations and the modulation of inner velocity by the outer structures show that there are two different formation mechanisms for the boundary layer. The trips with high aspect ratio and uniform distributed blockage leave the inner motions of the boundary layer relatively undisturbed, which subsequently drive the mixing of the obstacles' wake with the wall-bounded flow (wall-driven). In contrast, the low aspect-ratio trips with non-uniform blockage destroy the inner structures, which are then re-formed further downstream under the influence of the wake of the trips (wake-driven).

  16. Liver Enzymes Abnormalities among Highly Active Antiretroviral Therapy Experienced and HAART Naïve HIV-1 Infected Patients at Debre Tabor Hospital, North West Ethiopia: A Comparative Cross-Sectional Study

    PubMed Central

    Tulu, Ketema Tafess; Zegeye, Amtatachew Moges; Wubante, Amarech Asratie

    2016-01-01

    Liver disease has emerged as the most common non-AIDS-related cause of death in HIV patients. However, there is limited data regarding this condition including our setting in Ethiopia. Hence, liver enzyme abnormalities among highly active antiretroviral therapy (HAART) experienced and HAART naïve patients were assessed in this study. A total of 164 HAART experienced and 164 HAART naïve patients were studied. Blood specimen was collected to determine alanine aminotransferase (ALT) and aspartate aminotransferase (AST), CD4 count, and viral hepatitis. The prevalence of liver enzyme abnormality was 20.1% and 22.0% among HAART experienced and HAART naïve patients, respectively. The HAART experienced patients had higher mean ALT than HAART naïve patients (P = 0.002). Viral hepatitis (AOR = 6.02; 95% CI = 1.87–19.39), opportunistic infections (AOR = 2.91; 95% CI = 1.04–8.19), current CD4 count <200 cells/mm3 (AOR = 2.16; 95% CI = 1.06–4.39), and male sex (AOR = 1.83; 95% CI = 1.001–3.33) were associated with elevated ALT and/or AST. In conclusion, liver enzyme abnormalities were high in both HAART experienced and HAART naïve HIV-1 infected patients. Hence, monitoring and management of liver enzyme abnormalities in HIV-1 infected patients are important in our setting. PMID:27493798

  17. Spatial patterning of the neonatal EEG suggests a need for a high number of electrodes.

    PubMed

    Odabaee, Maryam; Freeman, Walter J; Colditz, Paul B; Ramon, Ceon; Vanhatalo, Sampsa

    2013-03-01

    There is an increasing demand for source analysis of neonatal EEG, but currently there is inadequate knowledge about i) the spatial patterning of neonatal scalp EEG and hence ii) the number of electrodes needed to capture neonatal EEG in full spatial detail. This study addresses these issues by using a very high density (2.5mm interelectrode spacing) linear electrode array to assess the spatial power spectrum, by using a high density (64 electrodes) EEG cap to assess the spatial extent of the common oscillatory bouts in the neonatal EEG and by using a neonatal size spherical head model to assess the effects of source depth and skull conductivities on the spatial frequency spectrum. The linear array recordings show that the spatial power spectrum decays rapidly until about 0.5-0.8 cycles per centimeter. The dense array EEG recordings show that the amplitude of oscillatory events decays within 4-6 cm to the level of global background activity, and that the higher frequencies (12-20 Hz) show the most rapid spatial decline in amplitude. Simulation with spherical head model showed that realistic variation in skull conductivity and source depths can both introduce orders of magnitude difference in the spatial frequency of the scalp EEG. Calculation of spatial Nyquist frequencies from the spatial power spectra suggests that an interelectrode distance of about 6-10mm would suffice to capture the full spatial texture of the raw EEG signal at the neonatal scalp without spatial aliasing or under-sampling. The spatial decay of oscillatory events suggests that a full representation of their spatial characteristics requires an interelectrode distance of 10-20mm. The findings show that the conventional way of recording neonatal EEG with about 10 electrodes ignores most spatial EEG content, that increasing the electrode density is necessary to improve neonatal EEG source localization and information extraction, and that prospective source models will need to carefully consider the

  18. An efficient numerical method for solving the time-dependent compressible Navier-Stokes equations at high Reynolds number

    NASA Technical Reports Server (NTRS)

    Maccormack, R. W.

    1976-01-01

    A new numerical method used to drastically reduce the computation time required to solve the Navier-Stokes equations at flight Reynolds numbers is described. The new method makes it possible and practical to calculate many important three-dimensional, high Reynolds number flow fields on computers.

  19. Right Liver Lobe Hypoplasia and Related Abnormalities

    PubMed Central

    Alicioglu, Banu

    2015-01-01

    Summary Background Hypoplasia and agenesis of the liver lobe is a rare abnormality. It is associated with biliary system abnormalities, high location of the right kidney, and right colon interposition. These patients are prone to gallstones, portal hypertension and possible surgical complications because of anatomical disturbance. Case Report Magnetic resonance imaging features of a rare case of hypoplasia of the right lobe of the liver in a sigmoid cancer patient are presented. Conclusions Hypoplasia of the right liver should not be confused with liver atrophy; indeed, associations with other coexistent abnormalities are also possible. Awareness and familiarity with these anomalies are necessary to avoid fatal surgical and interventional complications. PMID:26634012

  20. LEBU drag reduction in high Reynolds number boundary layers. [Large Eddy Break-Up

    NASA Technical Reports Server (NTRS)

    Anders, J. B.

    1989-01-01

    Conventional and inverted, outer-layer leading-edge breakup devices (LEBUs) were water tunnel tested on an axisymmetric body over the Re number range from 380,000 to 3.8 million. Test results indicate a sharp degradation of the LEBUs' drag-reduction mechanism with increasing Re number. The most likely result of this degradation is a decoupling of the inner and outer scales at higher Re numbers; due to this decoupling, the breakup of the large structures by outer-layer devices has minimal influence on the near-wall, shear-producing scales. This suggests that smaller devices, closer to the walls, may be required for operation at elevated Re numbers.

  1. Excitable dynamics in high-Lewis number premixed gas combustion at normal and microgravity

    NASA Technical Reports Server (NTRS)

    Pearlman, Howard

    1995-01-01

    Freely-propagating, premixed gas flames in high-Lewis (Le) number, quiescent mixtures are studied experimentally in tubes of various diameter at normal (lg) and microgravity (mu g). A premixture of lean butane and oxygen diluted with helium, argon, neon, nitrogen or a mixture of multiple diluents is examined such that the thermal diffusivity of the mixture (and to a lesser extent, the mass diffusivity of the rate-limiting component) is systematically varied. In effect, different diluents allow variation of the Le without changing the chemistry. The flames are recorded with high speed cinematography and their stability is visually assessed. Different modes of propagation were observed depending on the diameter of the tubes (different conductive heat loss), the composition of the mixture and the g-level. At 1g, four modes of propagation were observed in small and intermediate diameter tubes (large conductive heat loss): (1) steadily propagating flames, (2) radial and longitudinal pulsating flames, (3) 'wavering' flames, and (4) rotating spiral flames. As the diameter of the tube increases, the radial modes become more pronounced while the longitudinal modes systematically disappear. Also, multiple, simultaneous, spatially-separated 'pacemaker' sites are observed in intermediate and large diameter tubes. Each site starts as a small region of high luminosity and develops into a flamelet which assumes the form of one of the fore mentioned modes. These flamelets eventually interact, annihilate each other in their regions of intersection and merge at their newly created free-ends. For very large tubes, radially-propagating wave-trains (believed to be 'trigger waves') are observed. These are analogous to the radial pulsations observed in the smaller diameter tubes. At mu g, three modes of propagation have been observed: (1) steadily propagating flames, (2) radial and longitudinal pulsating flames, and (3) multi-armed, rotating flames. Since the pulsating mode exists at mu

  2. An autostereoscopic display with high resolution and large number of view zones

    NASA Astrophysics Data System (ADS)

    Chen, Wu-Li; Hsu, Wei-Liang; Tsai, Chao-Hsu; Wang, Chy-Lin; Wu, Chang-Shuo; Yang, Jinn-Cherng; Cheng, Shu-Chuan

    2008-02-01

    For a spatial-multiplexed 3D display, trade-off between resolution and number of view-zones are usually unavoidable due to the limited number of pixels on the screen. In this paper, we present a new autostereoscopic system, named as "integrated-screen system," to substantially increase the total number of pixels on the screen, which in turn increase both the resolution and number of view-zones. In the integrated-screen system, a large number of mini-projectors are arrayed and the images are tiled together without seams in between. For displaying 3D images, the lenticular screen with predesigned tilted angle is used for distributing different viewing zones. In order to achieve good performance, we design a brand-new projector with special lens set to meet the low-distortion requirement because the distortion of the image will induce serious crosstalk between view-zones. The proposed system has two advantages. One is the extensibility of the screen size. The size of the display can be chosen based on the applications we deal with, including the size of the projected pixel and the number of viewing zones. The other advantage is that the integrated-screen system provides projected pixels in great density to solve the major problem of the poor resolution that a lenticular-type 3D display has.

  3. Red-Backed Vole Brain Promotes Highly Efficient In Vitro Amplification of Abnormal Prion Protein from Macaque and Human Brains Infected with Variant Creutzfeldt-Jakob Disease Agent

    PubMed Central

    Nemecek, Julie; Nag, Nabanita; Carlson, Christina M.; Schneider, Jay R.; Heisey, Dennis M.; Johnson, Christopher J.; Asher, David M.; Gregori, Luisa

    2013-01-01

    Rapid antemortem tests to detect individuals with transmissible spongiform encephalopathies (TSE) would contribute to public health. We investigated a technique known as protein misfolding cyclic amplification (PMCA) to amplify abnormal prion protein (PrPTSE) from highly diluted variant Creutzfeldt-Jakob disease (vCJD)-infected human and macaque brain homogenates, seeking to improve the rapid detection of PrPTSE in tissues and blood. Macaque vCJD PrPTSE did not amplify using normal macaque brain homogenate as substrate (intraspecies PMCA). Next, we tested interspecies PMCA with normal brain homogenate of the southern red-backed vole (RBV), a close relative of the bank vole, seeded with macaque vCJD PrPTSE. The RBV has a natural polymorphism at residue 170 of the PrP-encoding gene (N/N, S/S, and S/N). We investigated the effect of this polymorphism on amplification of human and macaque vCJD PrPTSE. Meadow vole brain (170N/N PrP genotype) was also included in the panel of substrates tested. Both humans and macaques have the same 170S/S PrP genotype. Macaque PrPTSE was best amplified with RBV 170S/S brain, although 170N/N and 170S/N were also competent substrates, while meadow vole brain was a poor substrate. In contrast, human PrPTSE demonstrated a striking narrow selectivity for PMCA substrate and was successfully amplified only with RBV 170S/S brain. These observations suggest that macaque PrPTSE was more permissive than human PrPTSE in selecting the competent RBV substrate. RBV 170S/S brain was used to assess the sensitivity of PMCA with PrPTSE from brains of humans and macaques with vCJD. PrPTSE signals were reproducibly detected by Western blot in dilutions through 10-12 of vCJD-infected 10% brain homogenates. This is the first report showing PrPTSE from vCJD-infected human and macaque brains efficiently amplified with RBV brain as the substrate. Based on our estimates, PMCA showed a sensitivity that might be sufficient to detect PrPTSE in vCJD-infected human

  4. Red-backed vole brain promotes highly efficient in vitro amplification of abnormal prion protein from macaque and human brains infected with variant Creutzfeldt-Jakob disease agent.

    USGS Publications Warehouse

    Nemecek, Julie; Nag, Nabanita; Carlson, Christina M.; Schneider, Jay R.; Heisey, Dennis M.; Johnson, Christopher J.; Asher, David M.; Gregori, Luisa

    2013-01-01

    Rapid antemortem tests to detect individuals with transmissible spongiform encephalopathies (TSE) would contribute to public health. We investigated a technique known as protein misfolding cyclic amplification (PMCA) to amplify abnormal prion protein (PrPTSE) from highly diluted variant Creutzfeldt-Jakob disease (vCJD)-infected human and macaque brain homogenates, seeking to improve the rapid detection of PrPTSE in tissues and blood. Macaque vCJD PrPTSE did not amplify using normal macaque brain homogenate as substrate (intraspecies PMCA). Next, we tested interspecies PMCA with normal brain homogenate of the southern red-backed vole (RBV), a close relative of the bank vole, seeded with macaque vCJD PrPTSE. The RBV has a natural polymorphism at residue 170 of the PrP-encoding gene (N/N, S/S, and S/N). We investigated the effect of this polymorphism on amplification of human and macaque vCJD PrPTSE. Meadow vole brain (170N/N PrP genotype) was also included in the panel of substrates tested. Both humans and macaques have the same 170S/S PrP genotype. Macaque PrPTSE was best amplified with RBV 170S/S brain, although 170N/N and 170S/N were also competent substrates, while meadow vole brain was a poor substrate. In contrast, human PrPTSE demonstrated a striking narrow selectivity for PMCA substrate and was successfully amplified only with RBV 170S/S brain. These observations suggest that macaque PrPTSE was more permissive than human PrPTSE in selecting the competent RBV substrate. RBV 170S/S brain was used to assess the sensitivity of PMCA with PrPTSE from brains of humans and macaques with vCJD. PrPTSE signals were reproducibly detected by Western blot in dilutions through 10-12 of vCJD-infected 10% brain homogenates. This is the first report showing PrPTSE from vCJD-infected human and macaque brains efficiently amplified with RBV brain as the substrate. Based on our estimates, PMCA showed a sensitivity that might be sufficient to detect PrPTSE in v

  5. Reaching the Critical Mass: The Twenty Year Surge in High School Physics. Findings from the 2005 Nationwide Survey of High School Physics Teachers. AIP Report. Number R-442

    ERIC Educational Resources Information Center

    Neuschatz, Michael; McFarling, Mark; White, Susan

    2008-01-01

    This report traces the growth of high school physics in American school over the past twenty years. Highlights of the report include: (1) Enrollments in high school physics continue to grow; (2) Increase in number and proportion of physics teachers; (3) Number of students taking honors, advance placement or second-year physics course has nearly…

  6. Differences in Factors Affecting Various Crash Types with High Numbers of Fatalities and Injuries in China

    PubMed Central

    Wang, Kai; He, Jie; Ding, Jianxun; Shi, Qin; Wang, Changjun; Li, Pingfan

    2016-01-01

    Objectives Road traffic crashes that involve very high numbers of fatalities and injuries arouse public concern wherever they occur. In China, there are two categories of such crashes: a crash that results in 10–30 fatalities, 50–100 serious injuries or a total cost of 50–100 million RMB ($US8-16m) is a “serious road traffic crash” (SRTC), while a crash that is even more severe or costly is a “particularly serious road traffic crash” (PSRTC). The aim of this study is to identify the main factors affecting different types of these crashes (single-vehicle, head-on, rear-end and side impact) with the ultimate goal of informing prevention activities and policies. Methods Detailed descriptions of the SRTCs and PSRTCs that occurred from 2007 to 2014 were collected from the database “In-depth Investigation and Analysis System for Major Road Traffic Crashes” (IIASMRTC), which is maintained by the Traffic Management Research Institute of the Ministry of Public Security of China (TMRI). 18 main risk factors, which were categorized into four areas (participant, vehicle, road and environment-related) were chosen as potential independent variables for the multinomial logistic regression analysis. Comparisons were made among the single-vehicle, head-on, rear-end and side impact crashes in terms of factors affecting crash occurrence. Findings Five risk factors were significant for the six multinomial logistic regression models, which were location, vertical alignment, roadside safety rating, driver distraction and overloading of cargo. It was indicated that intersections were more likely to have side impact SRTCs and PSRTCs, especially with poor visibility at night. Overloaded freight vehicles were more likely to be involved in a rear-end crash than other freight vehicles. Driver distraction is an important risk factor for head-on crashes, while vertical alignment and roadside safety rating are positively associated with single-vehicle crashes. Conclusion Based

  7. Preliminary Investigation of Certain Laminar-Flow Airfoils for Application at High Speeds and Reynolds Numbers

    NASA Technical Reports Server (NTRS)

    Jacobs, E.N.; Abbott, Ira H.; von Doenhoff, A.E.

    1939-01-01

    In order to extend the useful range of Reynolds numbers of airfoils designed to take advantage of the extensive laminar boundary layers possible in an air stream of low turbulence, tests were made of the NACA 2412-34 and 1412-34 sections in the NACA low-turbulence tunnel. Although the possible extent of the laminar boundary layer on these airfoils is not so great as for specially designed laminar-flow airfoils, it is greater than that for conventional airfoils, and is sufficiently extensive so that at Reynolds numbers above 11,000,000 the laminar region is expected to be limited by the permissible 'Reynolds number run' and not by laminar separation as is the case with conventional airfoils. Drag measurements by the wake-survey method and pressure-distribution measurements were made at several lift coefficients through a range of Reynolds numbers up to 11,400,000. The drag scale-effect curve for the NACA 1412-34 is extrapolated to a Reynolds number of 30,000,000 on the basis of theoretical calculations of the skin friction. Comparable skin-friction calculations were made for the NACA 23012. The results indicate that, for certain applications at moderate values of the Reynolds number, the NACA 1412-34 and 2412-34 airfoils offer some advantages over such conventional airfoils as the NACA 23012. The possibility of maintaining a more extensive laminar boundary layer on these airfoils should result in a small drag reduction, and the absence of pressure peaks allows higher speeds to be reached before the compressibility burble is encountered. At lower Reynold numbers, below about 10,000,000, these airfoils have higher drags than airfoils designed to operate with very extensive laminar boundary layers.

  8. Coherent large-scale structures in high Reynolds number supersonic jets

    NASA Technical Reports Server (NTRS)

    Lepicovsky, J.; Ahuja, K. K.; Brown, W. H.; Burrin, R. H.

    1985-01-01

    The flow structure of a 50.8 mm (2 in) diameter jet operated at a full expanded Mach number of 1.37, with Reynolds numbers in the range 1.7 to 2.35 million, was examined for the first 20 jet diameters. To facilitate the study of the large scale structure, and determine any coherence, a discrete tone acoustic excitation method was used. Phase locked flow visualization as well as laser velocimeter quantitative measurements were made. The main conclusions derived from this study are: (1) large scale coherent like turbulence structures do exist in large Reynolds number supersonic jets, and they prevail even beyond the potential core; (2) the most preferential Strouhal number for these structures is in the vicinity of 0.4; and (3) quantitatively, the peak amplitudes of these structures are rather low, and are about 1% of the jet exit velocity. Finally, since a number of unique problems related to LV measurements in supersonic jets were encountered, a summary of these problems and lessons learned therefrom are also reported.

  9. Evaluation of high Reynolds number flow in a 180 degree turn-around-duct

    NASA Technical Reports Server (NTRS)

    Sandborn, V. A.; Marcy, S. J.

    1991-01-01

    Mean and turbulent velocities were measured for the flow in a 180 degree turn-around-duct over a Reynolds number range from 600,000 to greater than 900,000. The measurements were made in water using a forward scattering laser velocimeter. A duct of 100 x 10 cm constant cross-section, with a mean radius of curvature (centerline) of 10 cm was employed for the study. The measurements are in agreement with previous studies in that the use of local bulk velocity to nondimensionalize the mean and turbulent velocities reduce the Reynolds number variations. The basic phenomenon of relaminarization along the inner surface at the exit of the turn are similar to the flow observed at low Reynolds numbers. The separation bubble region shows a systematic variation with Reynolds number, however the Reynolds number effect may be of second order in the calculation of the overall flow. Large tangential, radial, and lateral turbulent velocities are measured along the outer surface of the turn.

  10. Chromosome abnormalities in glioma

    SciTech Connect

    Li, Y.S.; Ramsay, D.A.; Fan, Y.S.

    1994-09-01

    Cytogenetic studies were performed in 25 patients with gliomas. An interesting finding was a seemingly identical abnormality, an extra band on the tip of the short arm of chromosome 1, add(1)(p36), in two cases. The abnormality was present in all cells from a patient with a glioblastoma and in 27% of the tumor cells from a patient with a recurrent irradiated anaplastic astrocytoma; in the latter case, 7 unrelated abnormal clones were identified except 4 of those clones shared a common change, -Y. Three similar cases have been described previously. In a patient with pleomorphic astrocytoma, the band 1q42 in both homologues of chromosome 1 was involved in two different rearrangements. A review of the literature revealed that deletion of the long arm of chromosome 1 including 1q42 often occurs in glioma. This may indicate a possible tumor suppressor gene in this region. Cytogenetic follow-up studies were carried out in two patients and emergence of unrelated clones were noted in both. A total of 124 clonal breakpoints were identified in the 25 patients. The breakpoints which occurred three times or more were: 1p36, 1p22, 1q21, 1q25, 3q21, 7q32, 8q22, 9q22, 16q22, and 22q13.

  11. [Congenital foot abnormalities].

    PubMed

    Delpont, M; Lafosse, T; Bachy, M; Mary, P; Alves, A; Vialle, R

    2015-03-01

    The foot may be the site of birth defects. These abnormalities are sometimes suspected prenatally. Final diagnosis depends on clinical examination at birth. These deformations can be simple malpositions: metatarsus adductus, talipes calcaneovalgus and pes supinatus. The prognosis is excellent spontaneously or with a simple orthopedic treatment. Surgery remains outstanding. The use of a pediatric orthopedist will be considered if malposition does not relax after several weeks. Malformations (clubfoot, vertical talus and skew foot) require specialized care early. Clubfoot is characterized by an equine and varus hindfoot, an adducted and supine forefoot, not reducible. Vertical talus combines equine hindfoot and dorsiflexion of the forefoot, which is performed in the midfoot instead of the ankle. Skew foot is suspected when a metatarsus adductus is resistant to conservative treatment. Early treatment is primarily orthopedic at birth. Surgical treatment begins to be considered after walking age. Keep in mind that an abnormality of the foot may be associated with other conditions: malposition with congenital hip, malformations with syndromes, neurological and genetic abnormalities. PMID:25524290

  12. Airfoil stall penetration at constant pitch rate and high Reynolds number

    NASA Technical Reports Server (NTRS)

    Lorber, Peter F.; Carta, Franklin O.

    1989-01-01

    The model wing consists of a set of fiberglass panels mounted on a steel spar that spans the 8 ft test section of the UTRC Large Subsonic Wind Tunnel. The first use of this system was to measure surface pressures and flow conditions for a series of constant pitch rate ramps and sinusoidal oscillations a Mach number range, a Reynolds number range, and a pitch angle range. It is concluded that an increased pitch rate causes stall events to be delayed, strengthening of the stall vortex, increase in vortex propagation, and increase in unsteady airloads. The Mach number range causes a supersonic zone near the leading edge, stall vortex to be weaker, and a reduction of unsteady airloads.

  13. DRE-Enhanced Swept-Wing Natural Laminar Flow at High Reynolds Numbers

    NASA Technical Reports Server (NTRS)

    Malik, Mujeeb; Liao, Wei; Li, Fe; Choudhari, Meelan

    2013-01-01

    Nonlinear parabolized stability equations and secondary instability analyses are used to provide a computational assessment of the potential use of the discrete roughness elements (DRE) technology for extending swept-wing natural laminar flow at chord Reynolds numbers relevant to transport aircraft. Computations performed for the boundary layer on a natural laminar flow airfoil with a leading-edge sweep angle of 34.6deg, free-stream Mach number of 0.75 and chord Reynolds numbers of 17 x 10(exp 6), 24 x 10(exp 6) and 30 x 10(exp 6) suggest that DRE could delay laminar-turbulent transition by about 20% when transition is caused by stationary crossflow disturbances. Computations show that the introduction of small wavelength stationary crossflow disturbances (i.e., DRE) also suppresses the growth of most amplified traveling crossflow disturbances.

  14. Inertial migration of spherical particles in circular Poiseuille flow at moderately high Reynolds numbers

    NASA Astrophysics Data System (ADS)

    Shao, Xueming; Yu, Zhaosheng; Sun, Bo

    2008-10-01

    The inertial migration of spherical particles in a circular Poiseuille flow is numerically investigated for the tube Reynolds number up to 2200. The periodic boundary condition is imposed in the streamwise direction. The equilibrium positions, the migration velocity, and the angular velocity of a single particle in a tube cell are examined at different Reynolds numbers, particle-tube size ratios, and tube lengths. Inner equilibrium positions are observed as the Reynolds number exceeds a critical value, in qualitatively agreement with the previous experimental observations [J.-P. Matas, J. F. Morris, and E. Guazzelli, J. Fluid Mech. 515, 171 (2004)]. Our results indicate that the hydrodynamic interactions between the particles in different periodic cells have significant effects on the migration of the particles at the tube length being even as large as 6.7 particle diameters and they tend to stabilize the particles at the outer Segré-Silberberg equilibrium positions and to suppress the emergence of the inner equilibrium positions. A mirror-symmetric traveling-wave-like structure is observed when the particle Reynolds number is large enough. A pair of counter-rotating streamwise vortices exists at both upstream and downstream of the particle but with different rotating directions. The fluids in the half of the pipe without the particle flow more slowly and most fluids in the other half with the particle move faster with respect to the parabolic profile. The intensity of the structure is influenced by the local particle Reynolds number, the particle motion, and the tube length. In addition, the migration of multiple particles in a periodic tube cell is examined. We attribute the disparity in the critical particle Reynolds number for the occurrence of the inner particle annulus for the experiments and our simulations to the effect of the tube length or the periodic boundary condition in our numerical model.

  15. A High-Level Formalization of Floating-Point Number in PVS

    NASA Technical Reports Server (NTRS)

    Boldo, Sylvie; Munoz, Cesar

    2006-01-01

    We develop a formalization of floating-point numbers in PVS based on a well-known formalization in Coq. We first describe the definitions of all the needed notions, e.g., floating-point number, format, rounding modes, etc.; then, we present an application to polynomial evaluation for elementary function evaluation. The application already existed in Coq, but our formalization shows a clear improvement in the quality of the result due to the automation provided by PVS. We finally integrate our formalization into a PVS hardware-level formalization of the IEEE-854 standard previously developed at NASA.

  16. Abnormal pressures as hydrodynamic phenomena

    USGS Publications Warehouse

    Neuzil, C.E.

    1995-01-01

    So-called abnormal pressures, subsurface fluid pressures significantly higher or lower than hydrostatic, have excited speculation about their origin since subsurface exploration first encountered them. Two distinct conceptual models for abnormal pressures have gained currency among earth scientists. The static model sees abnormal pressures generally as relict features preserved by a virtual absence of fluid flow over geologic time. The hydrodynamic model instead envisions abnormal pressures as phenomena in which flow usually plays an important role. This paper develops the theoretical framework for abnormal pressures as hydrodynamic phenomena, shows that it explains the manifold occurrences of abnormal pressures, and examines the implications of this approach. -from Author

  17. A two-dimensional, TVD numerical scheme for inviscid, high Mach number flows in chemical equilibrium

    NASA Technical Reports Server (NTRS)

    Eberhardt, S.; Palmer, G.

    1986-01-01

    A new algorithm has been developed for hypervelocity flows in chemical equilibrium. Solutions have been achieved for Mach numbers up to 15 with no adverse effect on convergence. Two methods of coupling an equilibrium chemistry package have been tested, with the simpler method proving to be more robust. Improvements in boundary conditions are still required for a production-quality code.

  18. A high-resolution map of copy number variation in the cattle genome

    Technology Transfer Automated Retrieval System (TEKTRAN)

    We conducted a systematic study of the cattle copy number variation (CNV) using array comparative genomic hybridization (array CGH). Oligonucleotide CGH arrays were designed and fabricated to provide a genome-wide coverage with an average interval of 6 kb using the Bta3.1 genome assembly. Dual-lab...

  19. Entrainment Across a Sheared Density Interface in High Richardson Number Cavity Flow

    NASA Astrophysics Data System (ADS)

    Williamson, Nicholas; Kirkpartick, Michael; Armfield, Steve

    2015-11-01

    The turbulent entrainment of fluid across a sharp density interface has been examined experimentally in a purging cavity flow. In the experiments, a long straight cavity with sloped entry and exit boundaries is located in the base of a straight open channel. Saline fluid is entrained from the cavity into the overflow. The cavity geometry has been designed to ensure there is no separation of the overflow in the cavity region with the goal of obtaining a single mode of entrainment, related only to the interface properties rather than to cavity specific mechanisms. The bulk entrainment rate has been measured and correlated with bulk Richardson number over Ri = 1 . 0 - 20 at Reynolds number Re = 7100 - 15100 . The entrainment rate is shown to scale with the local bulk Richardson number E ~= CRi - 1 . 38 , very close to the established result for entrainment across a sharp two layer density interface in a recirculating water channel (Strang and Fernando, J Fluid Mech., 428, 2001) but with an order of magnitude lower coefficient C. Experiments instrumented with PIV/LIF were used to relate the bulk Ri to the local gradient Richardson number of the interface. In the cavity setting the interface appears to remain sharper, resulting in larger Rig and reduced entrainment.

  20. Status and future prospects of using numerical methods to study complex flows at High Reynolds numbers

    NASA Technical Reports Server (NTRS)

    Maccormack, R. W.

    1978-01-01

    The calculation of flow fields past aircraft configuration at flight Reynolds numbers is considered. Progress in devising accurate and efficient numerical methods, in understanding and modeling the physics of turbulence, and in developing reliable and powerful computer hardware is discussed. Emphasis is placed on efficient solutions to the Navier-Stokes equations.

  1. Fine mapping of copy number variations on two cattle genome assemblies using high density SNP array

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Btau_4.0 and UMD3.1 are two distinct cattle reference genome assemblies. In our previous study using the low density BovineSNP50 array, we reported a copy number variation (CNV) analysis on Btau_4.0 with 521 animals of 21 cattle breeds, yielding 682 CNV regions with a total length of 139.8 megabases...

  2. Reynolds number effects on supersonic asymmetrical flows over a cone at high angle of attack

    NASA Technical Reports Server (NTRS)

    Thomas, J. L.

    1991-01-01

    The supersonic viscous flow over a 5-degree half-angle cone at an angle of attack of four times the cone half-angle is studied computationally using both the conical and the three-dimensional Navier-Stokes equations. The numerical solutions were obtained with an implicit, upwind-biased algorithm. Asymmetrical flowfields of the absolute-instability type are found using the conical-flow equations which agree with published results. However, the absolute instabilities of the originally symmetric flow found with the conical equations do not occur in the three-dimensional simulations, although spurious asymmetric three-dimensional flows for symmetric bodies arise if the grid resolution is insufficient in the nose region. The asymmetric flows computed with the three-dimensional equations are convective instabilities and are possible if the local Reynolds number exceeds a critical value and a fixed geometric asymmetry is imposed. A continuous range of asymmetries can be developed, depending on the size of the disturbance and the Reynolds number. As the Reynolds number is increased, the asymmetries demonstrate a bistable behavior at levels of side force consistent with those predicted using the conical equations. Below a certain critical Reynolds number, any flow asymmetries arising from a geometrical asymmetry are damped with increasing distance downstream from the geometrical asymmetry.

  3. Calculating High School Graduation Rates. Education Policy Brief. Volume 6, Number 5, Spring 2008

    ERIC Educational Resources Information Center

    Stanley, Kylie R.; Spradlin, Terry E.; Plucker, Jonathan A.

    2008-01-01

    Reports consistently demonstrate that the attainment of a high school diploma is not simply of value to the individual student, but that the benefit of a high school diploma is reaped by the graduate's community as well. Most educators readily acknowledge the importance of dropout prevention and the significance of a high school diploma. A…

  4. Increased recombinant protein production owing to expanded opportunities for vector integration in high chromosome number Chinese hamster ovary cells.

    PubMed

    Yamano, Noriko; Takahashi, Mai; Ali Haghparast, Seyed Mohammad; Onitsuka, Masayoshi; Kumamoto, Toshitaka; Frank, Jana; Omasa, Takeshi

    2016-08-01

    Chromosomal instability is a characteristic of Chinese hamster ovary (CHO) cells. Cultures of these cells gradually develop heterogeneity even if established from a single cell clone. We isolated cells containing different numbers of chromosomes from a CHO-DG44-based human granulocyte-macrophage colony stimulating factor (hGM-CSF)-producing cell line and found that high chromosome number cells showed higher hGM-CSF productivity. Therefore, we focused on the relationship between chromosome aneuploidy of CHO cells and high recombinant protein-producing cell lines. Distribution and stability of chromosomes were examined in CHO-DG44 cells, and two cell lines expressing different numbers of chromosomes were isolated from the original CHO-DG44 cell line to investigate the effect of aneuploid cells on recombinant protein production. Both cell lines were stably transfected with a vector that expresses immunoglobulin G3 (IgG3), and specific antibody production rates were compared. Cells containing more than 30 chromosomes had higher specific antibody production rates than those with normal chromosome number. Single cell analysis of enhanced green fluorescent protein (Egfp)-gene transfected cells revealed that increased GFP expression was relative to the number of gene integration sites rather than the difference in chromosome numbers or vector locations. Our results suggest that CHO cells with high numbers of chromosomes contain more sites for vector integration, a characteristic that could be advantageous in biopharmaceutical production. PMID:26850366

  5. Feeling Abnormal: Simulation of Deviancy in Abnormal and Exceptionality Courses.

    ERIC Educational Resources Information Center

    Fernald, Charles D.

    1980-01-01

    Describes activity in which student in abnormal psychology and psychology of exceptional children classes personally experience being judged abnormal. The experience allows the students to remember relevant research, become sensitized to the feelings of individuals classified as deviant, and use caution in classifying individuals as abnormal.…

  6. Study of the motions contributing to the Reynolds stress in high and low Reynolds number turbulent boundary layers

    NASA Astrophysics Data System (ADS)

    Priyadarshana, P. J. A.; Klewicki, J. C.

    2004-12-01

    Physical experiments are used to explore the properties of the motions contributing to the Reynolds stresses in high and low Reynolds number turbulent boundary layers. The low Reynolds number smooth wall measurements (Rθ=1010, Rθ=2870, and Rθ=4850) were acquired in a large-scale low speed wind tunnel, while the high Reynolds number measurements [Rθ˜O(106)] were acquired at the Surface Layer Turbulence and Environmental Science Test site, Dugway, Utah. These high Reynolds number turbulent boundary layer data were acquired over nearly hydraulically smooth and rough walls. At each Reynolds number and surface roughness, data comparisons were made at approximately yp/2 and 2yp, where yp is the peak position of the Reynolds shear stress. Scale separation effects associated with increasing Rθ are analyzed via spectral measurements (u, v, and u-v cospectra), and by segregating the streamwise and wall-normal velocities according to their frequency content using simultaneous high- and low-pass filtering. A primary observation is that the predominant motions underlying the stress undergo a significant shift from large to intermediate scales as Rθ becomes large, irrespective of surface roughness. Quadrant analysis of the filtered signals is employed to clarify the correlated scales involved in the generation of the stress. Overall, it is apparent that the types of motions contributing to Reynolds stress undergo significant variations at comparable wall-normal locations (relative to yp) over the Reynolds number range explored.

  7. Schizophrenogenic Parenting in Abnormal Psychology Textbooks.

    ERIC Educational Resources Information Center

    Wahl, Otto F.

    1989-01-01

    Considers the treatment of family causation of schizophrenia in undergraduate abnormal psychology textbooks. Reviews texts published only after 1986. Points out a number of implications for psychologists which arise from the inclusion in these texts of the idea that parents cause schizophrenia, not the least of which is the potential for…

  8. Compressible Boundary Layer Predictions at High Reynolds Number using Hybrid LES/RANS Methods

    NASA Technical Reports Server (NTRS)

    Choi, Jung-Il; Edwards, Jack R.; Baurle, Robert A.

    2008-01-01

    Simulations of compressible boundary layer flow at three different Reynolds numbers (Re(sub delta) = 5.59x10(exp 4), 1.78x10(exp 5), and 1.58x10(exp 6) are performed using a hybrid large-eddy/Reynolds-averaged Navier-Stokes method. Variations in the recycling/rescaling method, the higher-order extension, the choice of primitive variables, the RANS/LES transition parameters, and the mesh resolution are considered in order to assess the model. The results indicate that the present model can provide good predictions of the mean flow properties and second-moment statistics of the boundary layers considered. Normalized Reynolds stresses in the outer layer are found to be independent of Reynolds number, similar to incompressible turbulent boundary layers.

  9. The cryogenic wind tunnel for high Reynolds number testing. Ph.D. Thesis

    NASA Technical Reports Server (NTRS)

    Kilgore, R. A.

    1974-01-01

    Experiments performed at the NASA Langley Research Center in a cryogenic low-speed continuous-flow tunnel and in a cryogenic transonic continuous-flow pressure tunnel have demonstrated the predicted changes in Reynolds number, drive power, and fan speed with temperature, while operating with nitrogen as the test gas. The experiments have also demonstrated that cooling to cryogenic temperatures by spraying liquid nitrogen directly into the tunnel circuit is practical and that tunnel temperature can be controlled within very close limits. Whereas most types of wind tunnel could operate with advantage at cryogenic temperatures, the continuous-flow fan-driven tunnel is particularly well suited to take full advantage of operating at these temperatures. A continuous-flow fan-driven cryogenic tunnel to satisfy current requirements for test Reynolds number can be constructed and operated using existing techniques. Both capital and operating costs appear acceptable.

  10. Determination of the Profile Drag of an Airplane Wing in Flight at High Reynolds Numbers

    NASA Technical Reports Server (NTRS)

    Bicknell, Joseph

    1939-01-01

    Flight tests were made to determine the profile-drag coefficients of a portion of the original wing surface of an all-metal airplane and of a portion of the wing made aerodynamically smooth and more nearly fair than the original section. The wing section was approximately the NACA 2414.5. The tests were carried out over a range of airplane speeds giving a maximum Reynolds number of 15,000,000. Tests were also carried out to locate the point of transition from laminar to turbulent boundary layer and to determine the velocity distribution along the upper surface of the wing. The profile-drag coefficients of the original and of the smooth wing portions at a Reynolds number of 15,000,000 were 0.0102 and 0.0068, respectively; i.e., the surface irregularities on the original wing increased the profile-drag coefficient 50 percent above that of the smooth wing.

  11. A hybridized method for computing high-Reynolds-number hypersonic flow about blunt bodies

    NASA Technical Reports Server (NTRS)

    Weilmuenster, K. J.; Hamilton, H. H., II

    1979-01-01

    A hybridized method for computing the flow about blunt bodies is presented. In this method the flow field is split into its viscid and inviscid parts. The forebody flow field about a parabolic body is computed. For the viscous solution, the Navier-Stokes equations are solved on orthogonal parabolic coordinates using explicit finite differencing. The inviscid flow is determined by using a Moretti type scheme in which the Euler equations are solved, using explicit finite differences, on a nonorthogonal coordinate system which uses the bow shock as an outer boundary. The two solutions are coupled along a common data line and are marched together in time until a converged solution is obtained. Computed results, when compared with experimental and analytical results, indicate the method works well over a wide range of Reynolds numbers and Mach numbers.

  12. Skin Friction at Very High Reynolds Numbers in the National Transonic Facility

    NASA Technical Reports Server (NTRS)

    Watson, Ralph D.; Anders, John B.; Hall, Robert M.

    2006-01-01

    Skin friction coefficients were derived from measurements using standard measurement technologies on an axisymmetric cylinder in the NASA Langley National Transonic Facility (NTF) at Mach numbers from 0.2 to 0.85. The pressure gradient was nominally zero, the wall temperature was nominally adiabatic, and the ratio of boundary layer thickness to model diameter within the measurement region was 0.10 to 0.14, varying with distance along the model. Reynolds numbers based on momentum thicknesses ranged from 37,000 to 605,000. The measurements approximately doubled the range of available data for flat plate skin friction coefficients. Three different techniques were used to measure surface shear. The maximum error of Preston tube measurements was estimated to be 2.5 percent, while that of Clauser derived measurements was estimated to be approximately 5 percent. Direct measurements by skin friction balance proved to be subject to large errors and were not considered reliable.

  13. Development and Application of Plasma Actuators for Active Control of High-Speed and High Reynolds Number Flows

    NASA Technical Reports Server (NTRS)

    Sammy, Mo

    2010-01-01

    Active flow control is often used to manipulate flow instabilities to achieve a desired goal (e.g. prevent separation, enhance mixing, reduce noise, etc.). Instability frequencies normally scale with flow velocity scale and inversely with flow length scale (U/l). In a laboratory setting for such flow experiments, U is high, but l is low, resulting in high instability frequency. In addition, high momentum and high background noise & turbulence in the flow necessitate high amplitude actuation. Developing a high amplitude and high frequency actuator is a major challenge. Ironically, these requirements ease up in application (but other issues arise).

  14. A Highly Polymorphic Copy Number Variant in the NSF Gene is Associated with Cocaine Dependence

    PubMed Central

    Cabana-Domínguez, Judit; Roncero, Carlos; Grau-López, Lara; Rodríguez-Cintas, Laia; Barral, Carmen; Abad, Alfonso C.; Erikson, Galina; Wineinger, Nathan E.; Torrico, Bàrbara; Arenas, Concepció; Casas, Miquel; Ribasés, Marta; Cormand, Bru; Fernàndez-Castillo, Noèlia

    2016-01-01

    Cocaine dependence is a complex psychiatric disorder involving both genetic and environmental factors. Several neurotransmitter systems mediate cocaine’s effects, dependence and relapse, being the components of the neurotransmitter release machinery good candidates for the disorder. Previously, we identified a risk haplotype for cocaine dependence in the NSF gene, encoding the protein N-Ethylmaleimide-Sensitive Factor essential for synaptic vesicle turnover. Here we examined the possible contribution to cocaine dependence of a large copy number variant (CNV) that encompasses part of the NSF gene. We performed a case-control association study in a discovery sample (359 cases and 356 controls) and identified an association between cocaine dependence and the CNV (P = 0.013), that was confirmed in the replication sample (508 cases and 569 controls, P = 7.1e-03) and in a pooled analysis (P = 1.8e-04), with an over-representation of low number of copies in cases. Subsequently, we studied the functional impact of the CNV on gene expression and found that the levels of two NSF transcripts were significantly increased in peripheral blood mononuclear cells (PBMC) along with the number of copies of the CNV. These results, together with a previous study from our group, support the role of NSF in the susceptibility to cocaine dependence. PMID:27498889

  15. Large-eddy simulations of impinging jets at high Reynolds numbers

    NASA Astrophysics Data System (ADS)

    Wu, Wen; Piomelli, Ugo

    2013-11-01

    We have performed large-eddy simulations of an impinging jet with embedded azimuthal vortices. We used a hybrid approach in which the near-wall layer is modelled using the RANS equations with the Spalart-Allmaras model, while away from the wall Lagrangian-averaged dynamic eddy-viscosity modelled LES is used. This method allowed us to reach Reynolds numbers that would be prohibitively expensive for wall-resolving LES. First, we compared the results of the hybrid calculation with a wall-resolved one at moderate Reynolds number, Re = 66 , 000 (based on jet diameter and velocity). The mean velocity and Reynolds stresses were in good agreement between the simulations, and, in particular, the generation of secondary vorticity at the wall and its liftup were captured well. The simulation cost was reduced by 86%. We then carried out simulations at Re = 266 , 000 and 1.3 million. The effect of Reynolds number on vortex development will be discussed. Canada Research Chair in Computational Turbulence, HPCVL-Sun Microsystems Chair in Computational Science and Engineering.

  16. High-topological-number magnetic skyrmions and topologically protected dissipative structure

    NASA Astrophysics Data System (ADS)

    Zhang, Xichao; Zhou, Yan; Ezawa, Motohiko

    2016-01-01

    The magnetic skyrmion with the topological number of unity (Q =1 ) is a well-known nanometric swirling spin structure in the nonlinear σ model with the Dzyaloshinskii-Moriya interaction. Here we show that magnetic skyrmion with the topological number of two (Q =2 ) can be created and stabilized by applying vertical spin-polarized current though it cannot exist as a static stable excitation. Magnetic skyrmion with Q =2 is a nonequilibrium dynamic object, subsisting on a balance between the energy injection from the current and the energy dissipation by the Gilbert damping. Once it is created, it becomes a topologically protected object against fluctuations of various variables including the injected current itself. Hence we may call it a topologically protected dissipative structure. We also elucidate the nucleation and destruction mechanisms of the magnetic skyrmion with Q =2 by studying the evolutions of the magnetization distribution, the topological charge density, as well as the energy density. Our results will be useful for the study of the nontrivial topology of magnetic skyrmions with higher topological numbers.

  17. A Highly Polymorphic Copy Number Variant in the NSF Gene is Associated with Cocaine Dependence.

    PubMed

    Cabana-Domínguez, Judit; Roncero, Carlos; Grau-López, Lara; Rodríguez-Cintas, Laia; Barral, Carmen; Abad, Alfonso C; Erikson, Galina; Wineinger, Nathan E; Torrico, Bàrbara; Arenas, Concepció; Casas, Miquel; Ribasés, Marta; Cormand, Bru; Fernàndez-Castillo, Noèlia

    2016-01-01

    Cocaine dependence is a complex psychiatric disorder involving both genetic and environmental factors. Several neurotransmitter systems mediate cocaine's effects, dependence and relapse, being the components of the neurotransmitter release machinery good candidates for the disorder. Previously, we identified a risk haplotype for cocaine dependence in the NSF gene, encoding the protein N-Ethylmaleimide-Sensitive Factor essential for synaptic vesicle turnover. Here we examined the possible contribution to cocaine dependence of a large copy number variant (CNV) that encompasses part of the NSF gene. We performed a case-control association study in a discovery sample (359 cases and 356 controls) and identified an association between cocaine dependence and the CNV (P = 0.013), that was confirmed in the replication sample (508 cases and 569 controls, P = 7.1e-03) and in a pooled analysis (P = 1.8e-04), with an over-representation of low number of copies in cases. Subsequently, we studied the functional impact of the CNV on gene expression and found that the levels of two NSF transcripts were significantly increased in peripheral blood mononuclear cells (PBMC) along with the number of copies of the CNV. These results, together with a previous study from our group, support the role of NSF in the susceptibility to cocaine dependence. PMID:27498889

  18. High Fidelity Copy Number Analysis of Formalin-Fixed and Paraffin-Embedded Tissues Using Affymetrix Cytoscan HD Chip

    PubMed Central

    Yu, Yan P.; Michalopoulos, Amantha; Ding, Ying; Tseng, George; Luo, Jian-Hua

    2014-01-01

    Detection of human genome copy number variation (CNV) is one of the most important analyses in diagnosing human malignancies. Genome CNV detection in formalin-fixed and paraffin-embedded (FFPE) tissues remains challenging due to suboptimal DNA quality and failure to use appropriate baseline controls for such tissues. Here, we report a modified method in analyzing CNV in FFPE tissues using microarray with Affymetrix Cytoscan HD chips. Gel purification was applied to select DNA with good quality and data of fresh frozen and FFPE tissues from healthy individuals were included as baseline controls in our data analysis. Our analysis showed a 91% overlap between CNV detection by microarray with FFPE tissues and chromosomal abnormality detection by karyotyping with fresh tissues on 8 cases of lymphoma samples. The CNV overlap between matched frozen and FFPE tissues reached 93.8%. When the analyses were restricted to regions containing genes, 87.1% concordance between FFPE and fresh frozen tissues was found. The analysis was further validated by Fluorescence In Situ Hybridization on these samples using probes specific for BRAF and CITED2. The results suggested that the modified method using Affymetrix Cytoscan HD chip gave rise to a significant improvement over most of the previous methods in terms of accuracy in detecting CNV in FFPE tissues. This FFPE microarray methodology may hold promise for broad application of CNV analysis on clinical samples. PMID:24699316

  19. Abnormal human sex chromosome constitutions

    SciTech Connect

    1993-12-31

    Chapter 22, discusses abnormal human sex chromosome constitution. Aneuploidy of X chromosomes with a female phenotype, sex chromosome aneuploidy with a male phenotype, and various abnormalities in X chromosome behavior are described. 31 refs., 2 figs.

  20. Exercises to Improve Gait Abnormalities

    MedlinePlus

    ... Home About iChip Articles Directories Videos Resources Contact Exercises to Improve Gait Abnormalities Home » Article Categories » Exercise and Fitness Font Size: A A A A Exercises to Improve Gait Abnormalities Next Page The manner ...

  1. Experimental study of the effects of Reynolds number on high angle of attack aerodynamic characteristics of forebodies during rotary motion

    NASA Technical Reports Server (NTRS)

    Pauley, H.; Ralston, J.; Dickes, E.

    1995-01-01

    The National Aeronautics and Space Administration and the Defense Research Agency (United Kingdom) have ongoing experimental research programs in rotary-flow aerodynamics. A cooperative effort between the two agencies is currently underway to collect an extensive database for the development of high angle of attack computational methods to predict the effects of Reynolds number on the forebody flowfield at dynamic conditions, as well as to study the use of low Reynolds number data for the evaluation of high Reynolds number characteristics. Rotary balance experiments, including force and moment and surface pressure measurements, were conducted on circular and rectangular aftbodies with hemispherical and ogive noses at the Bedford and Farnborough wind tunnel facilities in the United Kingdom. The bodies were tested at 60 and 90 deg angle of attack for a wide range of Reynolds numbers in order to observe the effects of laminar, transitional, and turbulent flow separation on the forebody characteristics when rolling about the velocity vector.

  2. Analysis of Fluctuating Static Pressure Measurements in a Large High Reynolds Number Transonic Cryogenic Wind Tunnel. Ph.D. Thesis

    NASA Technical Reports Server (NTRS)

    Igoe, William B.

    1991-01-01

    Dynamic measurements of fluctuating static pressure levels were made using flush mounted high frequency response pressure transducers at eleven locations in the circuit of the National Transonic Facility (NTF) over the complete operating range of this wind tunnel. Measurements were made at test section Mach numbers from 0.2 to 1.2, at pressure from 1 to 8.6 atmospheres and at temperatures from ambient to -250 F, resulting in dynamic flow disturbance measurements at the highest Reynolds numbers available in a transonic ground test facility. Tests were also made independently at variable Mach number, variable Reynolds number, and variable drivepower, each time keeping the other two variables constant thus allowing for the first time, a distinct separation of these three important variables. A description of the NTF emphasizing its flow quality features, details on the calibration of the instrumentation, results of measurements with the test section slots covered, downstream choke, effects of liquid nitrogen injection and gaseous nitrogen venting, comparisons between air and nitrogen, isolation of the effects of Mach number, Reynolds number, and fan drive power, and identification of the sources of significant flow disturbances is included. The results indicate that primary sources of flow disturbance in the NTF may be edge-tones generated by test section sidewall re-entry flaps and the venting of nitrogen gas from the return leg of the tunnel circuit between turns 3 and 4 in the cryogenic mode of operation. The tests to isolate the effects of Mach number, Reynolds number, and drive power indicate that Mach number effects predominate. A comparison with other transonic wind tunnels shows that the NTF has low levels of test section fluctuating static pressure especially in the high subsonic Mach number range from 0.7 to 0.9.

  3. Number Sense-Based Strategies Used by High-Achieving Sixth Grade Students Who Experienced Reform Textbooks

    ERIC Educational Resources Information Center

    Alsawaie, Othman N.

    2012-01-01

    The purpose of this study was to explore strategies used by high-achieving 6th grade students in the United Arab Emirates (UAE) to solve basic arithmetic problems involving number sense. The sample for the study consisted of 15 high-achieving boys and 15 high-achieving girls in grade 6 from 2 schools in the Emirate of Abu Dhabi, UAE. Data for the…

  4. Upper esophageal sphincter abnormalities are strongly predictive of treatment response in patients with achalasia

    PubMed Central

    Mathews, Simon C; Ciarleglio, Maria; Chavez, Yamile Haito; Clarke, John O; Stein, Ellen; Chander Roland, Bani

    2014-01-01

    AIM: To investigate the relationship between upper esophageal sphincter abnormalities achalasia treatment METHODS: We performed a retrospective study of 41 consecutive patients referred for high resolution esophageal manometry with a final manometric diagnosis of achalasia. Patients were sub-divided by presence or absence of Upper esophageal sphincter (UES) abnormality, and clinical and manometric profiles were compared. Correlation between UES abnormality and sub-type (i.e., hypertensive, hypotensive or impaired relaxation) and a number of variables, including qualitative treatment response, achalasia sub-type, co-morbid medical illness, psychiatric illness, surgical history, dominant presenting symptom, treatment type, age and gender were also evaluated. RESULTS: Among all 41 patients, 24 (58.54%) had a UES abnormality present. There were no significant differences between the groups in terms of age, gender or any other clinical or demographic profiles. Among those with UES abnormalities, the majority were either hypertensive (41.67%) or had impaired relaxation (37.5%) as compared to hypotensive (20.83%), although this did not reach statistical significance (P = 0.42). There was no specific association between treatment response and treatment type received; however, there was a significant association between UES abnormalities and treatment response. In patients with achalasia and concomitant UES abnormalities, 87.5% had poor treatment response, while only 12.5% had favorable response. In contrast, in patients with achalasia and no UES abnormalities, the majority (78.57%) had good treatment response, as compared to 21.43% with poor treatment response (P = 0.0001). After controlling for achalasia sub-type, those with UES abnormality had 26 times greater odds of poor treatment response than those with no UES abnormality (P = 0.009). Similarly, after controlling for treatment type, those with UES abnormality had 13.9 times greater odds of poor treatment response

  5. The Polish Folk High Schools. Occasional Papers in Continuing Education. Number 17.

    ERIC Educational Resources Information Center

    Kulich, Jindra; Bron-Wojciechowska, Agnieszka

    Polish folk high schools are modeled after schools developed in the mid-1850s in Denmark to provide general, non-credit education for young adults in rural areas. The main objectives of the folk high schools are to provide a climate for individual student development and to serve as centers where young adults can learn about their cultural…

  6. High School Redesign. Diplomas Count, 2016. Education Week. Volume 35, Number 33

    ERIC Educational Resources Information Center

    Edwards, Virginia B., Ed.

    2016-01-01

    This year's report focuses on efforts to redesign high schools. Those include incorporating student voice, implementing a rigorous and relevant curriculum, embracing career exploration, and more. The report also includes the latest statistics on the nation's overall, on-time high school graduation rate. Articles include: (1) To Build a Better High…

  7. Summer Mathematics Remediation for Incoming Pupils; 1975 High School Umbrella Number 2.

    ERIC Educational Resources Information Center

    Siegelman, Marvin

    Funded under Elementary Secondary Education Act Title I, the Summer Remediation for Incoming Pupils 1975 High School Umbrella #2 program (RIP) was designed to provide remedial instruction in mathematics to incoming ninth and tenth grade pupils who had attended Title I junior high or intermediate schools. The program was designed to bridge the gap…

  8. Analysis of Turbulent Flow and Heat Transfer on a Flat Plate at High Mach Numbers with Variable Fluid Properties

    NASA Technical Reports Server (NTRS)

    Deissler, R. G.; Loeffler, A. L., Jr.

    1959-01-01

    A previous analysis of turbulent heat transfer and flow with variable fluid properties in smooth passages is extended to flow over a flat plate at high Mach numbers, and the results are compared with experimental data. Velocity and temperature distributions are calculated for a boundary layer with appreciative effects of frictional heating and external heat transfer. Viscosity and thermal conductivity are assumed to vary as a power or the temperature, while Prandtl number and specific heat are taken as constant. Skin-friction and heat-transfer coefficients are calculated and compared with the incompressible values. The rate of boundary-layer growth is obtained for various Mach numbers.

  9. Study on the dynamic characteristics of flow over building cluster at high Reynolds number by large eddy simulation

    NASA Astrophysics Data System (ADS)

    Wang, BoBin; Wang, ZhiShi; Cui, GuiXiang; Zhang, ZhaoShun

    2014-06-01

    In this paper, the dynamic characteristics of building clusters are simulated by large eddy simulation at high Reynolds number for both homogeneous and heterogeneous building clusters. To save the computational cost a channel-like flow model is applied to the urban canopy with free slip condition at the upper boundary. The results show that the domain height is an important parameter for correct evaluation of the dynamic characteristics. The domain height must be greater than 8 h ( h is the average building height) in order to obtain correct roughness height while displacement height and roughness sublayer are less sensitive to the domain height. The Reynolds number effects on the dynamic characteristics and flow patterns are investigated. The turbulence intensity is stronger inside building cluster at high Reynolds number while turbulence intensity is almost unchanged with Reynolds number above the building cluster. Roughness height increases monotonously with Reynolds number by 20% from Re*=103 to Re*=105 but displacement height is almost unchanged. Within the canopy layer of heterogeneous building clusters, flow structures vary between buildings and turbulence is more active at high Reynolds number.

  10. Plume generation in natural thermal convection at high Rayleigh and Prandtl numbers

    NASA Astrophysics Data System (ADS)

    Lithgow-Bertelloni, C.; Richards, M. A.; Conrad, C. P.; Griffiths, R. W.

    2001-05-01

    We study natural thermal convection of a fluid (corn syrup) with a large Prandtl number (103 107) and temperature-dependent viscosity. The experimental tank (1 × 1 × 0.3m) is heated from below with insulating top and side boundaries, so that the fluid experiences secular heating as experiments proceed. This setup allows a focused study of thermal plumes from the bottom boundary layer over a range of Rayleigh numbers relevant to convective plumes in the deep interior of the Earth's mantle. The effective value of Ra, based on the viscosity of the fluid at the interior temperature, varies from 105 at the beginning to almost 108 toward the end of the experiments. Thermals (plumes) from the lower boundary layer are trailed by continuous conduits with long residence times. Plumes dominate flow in the tank, although there is a weaker large-scale circulation induced by material cooling at the imperfectly insulating top and sidewalls. At large Ra convection is extremely time-dependent and exhibits episodic bursts of plumes, separated by periods of quiescence. This bursting behaviour probably results from the inability of the structure of the thermal boundary layer and its instabilities to keep pace with the rate of secular change in the value of Ra. The frequency of plumes increases and their size decreases with increasing Ra, and we characterize these changes via in situ thermocouple measurements, shadowgraph videos, and videos of liquid crystal films recorded during several experiments. A scaling analysis predicts observed changes in plume head and tail radii with increasing Ra. Since inertial effects are largely absent no transition to ‘hard’ thermal turbulence is observed, in contrast to a previous conclusion from numerical calculations at similar Rayleigh numbers. We suggest that bursting behaviour similar to that observed may occur in the Earth's mantle as it undergoes secular cooling on the billion-year time scale.

  11. Design of high-Reynolds-number flat-plate experiments in the NTF

    NASA Technical Reports Server (NTRS)

    Saric, William S.

    1988-01-01

    The design of an experiment to measure skin friction and turbulent boundary layer characteristics at Reynolds numbers exceeding 1 x 10 to the 9th is described. The experiment will be conducted in a zero-pressure-gradient flow on a flat plate in the National Transonic Facility (NTF). The development of computational codes to analyze the aerodynamic loads and the blockage is documented. Novel instrumentation techniques and models, designed to operate in cryogenic environments, are presented. Special problems associated with aerodynamic loads, surface finish, and hot-wire anemometers are discussed.

  12. Design of high-Reynolds-number flat-plate experiments in the NTF

    NASA Technical Reports Server (NTRS)

    Saric, W. S.; Peterson, J. B., Jr.

    1984-01-01

    The design of an experiment to measure skin friction and turbulent boundary-layer characteristics at Reynolds numbers exceeding one billion is described. The experiment will be conducted in a zero-pressure-gradient flow on a flat plate in the National Transonic Facility. The development of computational codes to analyze the aerodynamic loads and the blockage is documented. Novel instrumentationn techniques and models, designed to operate in cryogenic environments, are presented. Special problems associated with aerodynamic loads, surface finish, and hot-wire anemometers are discussed.

  13. Curling dynamics of naturally curved ribbons from high to low Reynolds numbers

    NASA Astrophysics Data System (ADS)

    Albarran Arriagada, Octavio; Massiera, Gladys; Abkarian, Manouk

    2012-11-01

    Curling deformation of thin elastic sheets appears in numerous structures in nature, such as membranes of red blood cells, epithelial tissues or green algae colonies to cite just a few examples. However, despite its ubiquity, the dynamics of curling propagation in a naturally curved material remains still poorly investigated. Here, we present a coupled experimental and theoretical study of the dynamical curling deformation of naturally curved ribbons. Using thermoplastic and metallic ribbons molded on cylinders of different radii, we tune separately the natural curvature and the geometry to study curling dynamics in air, water and in viscous oils, thus spanning a wide range of Reynolds numbers. Our theoretical and experimental approaches separate the role of elasticity, gravity and hydrodynamic dissipation from inertia and emphasize the fundamental differences between the curling of a naturally curved ribbon and a rod described by the classical Elastica. Our work shows evidence for the propagation of a single instability front, selected by a local buckling condition. We show that depending on gravity, and both the Reynolds and the Cauchy numbers, the curling speed and shape are modified by the large scale drag and the local lubrication forces. This work was supported by the French Ministry of Research, the CNRS Physics-Chemistry-Biology Interdisciplinary Pro- gram, the University Montpellier 2 Interdisciplinary Program and the Region Languedoc-Roussillon.

  14. Statistical structure of spanwise vorticity in high Reynolds number rough-wall turbulent boundary layers

    NASA Astrophysics Data System (ADS)

    Morrill-Winter, Caleb; Klewicki, Joseph; Marusic, Ivan

    2014-11-01

    A defining characteristic of boundary layers is the presence of vorticity. Within the 2-D turbulent boundary layer the only component of vorticity to have a non-negligible mean value is the spanwise component, ωz. In the present experiments, a compact four element (``Foss-style'') hotwire probe was used to acquire well-resolved ωz fluctuations over the range, 3 , 000 <=δ+ = δuτ / ν <= 20 , 000 for 36 grit sandpaper roughness. Over the entire Reynolds number range good spatial resolution was maintained by utilizing the low speed, large scale attributes of the HRNBLWT at the University of Melbourne. The present talk addresses the statistical structure of ωz above a rough wall including comparisons with its smooth wall counterpart. The observed low Reynolds number smooth wall self-similarity between the mean and the rms profiles of ωz is clarified for the rough-wall case. The rough wall ωz behavior is described in a context consistent with the mean momentum equation. The support of the Australian Research Council is gratefully acknowledged.

  15. Revisiting Turbulence Model Validation for High-Mach Number Axisymmetric Compression Corner Flows

    NASA Technical Reports Server (NTRS)

    Georgiadis, Nicholas J.; Rumsey, Christopher L.; Huang, George P.

    2015-01-01

    Two axisymmetric shock-wave/boundary-layer interaction (SWBLI) cases are used to benchmark one- and two-equation Reynolds-averaged Navier-Stokes (RANS) turbulence models. This validation exercise was executed in the philosophy of the NASA Turbulence Modeling Resource and the AIAA Turbulence Model Benchmarking Working Group. Both SWBLI cases are from the experiments of Kussoy and Horstman for axisymmetric compression corner geometries with SWBLI inducing flares of 20 and 30 degrees, respectively. The freestream Mach number was approximately 7. The RANS closures examined are the Spalart-Allmaras one-equation model and the Menter family of kappa - omega two equation models including the Baseline and Shear Stress Transport formulations. The Wind-US and CFL3D RANS solvers are employed to simulate the SWBLI cases. Comparisons of RANS solutions to experimental data are made for a boundary layer survey plane just upstream of the SWBLI region. In the SWBLI region, comparisons of surface pressure and heat transfer are made. The effects of inflow modeling strategy, grid resolution, grid orthogonality, turbulent Prandtl number, and code-to-code variations are also addressed.

  16. Entropy Splitting for High Order Numerical Simulation of Vortex Sound at Low Mach Numbers

    NASA Technical Reports Server (NTRS)

    Mueller, B.; Yee, H. C.; Mansour, Nagi (Technical Monitor)

    2001-01-01

    A method of minimizing numerical errors, and improving nonlinear stability and accuracy associated with low Mach number computational aeroacoustics (CAA) is proposed. The method consists of two levels. From the governing equation level, we condition the Euler equations in two steps. The first step is to split the inviscid flux derivatives into a conservative and a non-conservative portion that satisfies a so called generalized energy estimate. This involves the symmetrization of the Euler equations via a transformation of variables that are functions of the physical entropy. Owing to the large disparity of acoustic and stagnation quantities in low Mach number aeroacoustics, the second step is to reformulate the split Euler equations in perturbation form with the new unknowns as the small changes of the conservative variables with respect to their large stagnation values. From the numerical scheme level, a stable sixth-order central interior scheme with a third-order boundary schemes that satisfies the discrete analogue of the integration-by-parts procedure used in the continuous energy estimate (summation-by-parts property) is employed.

  17. Resolution of direction of arrival and number of signal(s) in a highly noisy environment

    NASA Astrophysics Data System (ADS)

    Beyon, Jeffrey Y.; Thomopoulos, Stelios C.

    1998-07-01

    The majority of Direction-of-Arrival (DOA) estimation methods studied in the literature work effectively in relatively strong signal power environment [positive dB of Array- Signal-to-Noise-Ratio (ASNR)]. In weak power signal environments, conventional beamformer-based and subspace-based methods fail to estimate the DOA correctly. The MaxMax method allows to maintain accurate estimates of the DOA even in extremely noisy environments (-10 dB of ASNR). The method is reviewed and its performance is compared with that of the Conventional Beamformer, Capon's Beamformer, MUSIC, ESPRIT, and Min-Norm methods. In contrast with the subspace-based methods which entirely depend on the full rank signal covariance matrix, the MaxMax method does not. Hence, the performance of the method remains superior to that of the others without adjusting the algorithm to the characteristics of source signals such as multipath or singlepath. If the signal power is so weak that its presence is almost negligible, Akaike's Information Criterion (AIC) or Minimum Description Length (MDL) do not yield correct estimates the number of signal paths. A new 'spatial sampling' technique and its performance are presented for estimating the number of signals in case of strongly suppressed signal power.

  18. Spirometric abnormalities among welders

    SciTech Connect

    Rastogi, S.K.; Gupta, B.N.; Husain, T.; Mathur, N.; Srivastava, S. )

    1991-10-01

    A group of manual welders age group 13-60 years having a mean exposure period of 12.4 {plus minus} 1.12 years were subjected to spirometry to evaluate the prevalence of spirometric abnormalities. The welders showed a significantly higher prevalence of respiratory impairment than that observed among the unexposed controls as a result of exposure to welding gases which comprised fine particles of lead, zinc, chromium, and manganese. This occurred despite the lower concentration of the pollutants at the work place. In the expose group, the smoking welders showed a prevalence of respiratory impairment significantly higher than that observed in the nonsmoking welders. The results of the pulmonary function tests showed a predominantly restrictive type of pulmonary impairment followed by a mixed ventilatory defect among the welders. The effect of age on pulmonary impairment was not discernible. Welders exposed for over 10 years showed a prevalence of respiratory abnormalities significantly higher than those exposed for less than 10 years. Smoking also had a contributory role.

  19. Lack of Evidence for Regional Brain Volume or Cortical Thickness Abnormalities in Youths at Clinical High Risk for Psychosis: Findings From the Longitudinal Youth at Risk Study.

    PubMed

    Klauser, Paul; Zhou, Juan; Lim, Joseph K W; Poh, Joann S; Zheng, Hui; Tng, Han Ying; Krishnan, Ranga; Lee, Jimmy; Keefe, Richard S E; Adcock, R Alison; Wood, Stephen J; Fornito, Alex; Chee, Michael W L

    2015-11-01

    There is cumulative evidence that young people in an "at-risk mental state" (ARMS) for psychosis show structural brain abnormalities in frontolimbic areas, comparable to, but less extensive than those reported in established schizophrenia. However, most available data come from ARMS samples from Australia, Europe, and North America while large studies from other populations are missing. We conducted a structural brain magnetic resonance imaging study from a relatively large sample of 69 ARMS individuals and 32 matched healthy controls (HC) recruited from Singapore as part of the Longitudinal Youth At-Risk Study (LYRIKS). We used 2 complementary approaches: a voxel-based morphometry and a surface-based morphometry analysis to extract regional gray and white matter volumes (GMV and WMV) and cortical thickness (CT). At the whole-brain level, we did not find any statistically significant difference between ARMS and HC groups concerning total GMV and WMV or regional GMV, WMV, and CT. The additional comparison of 2 regions of interest, hippocampal, and ventricular volumes, did not return any significant difference either. Several characteristics of the LYRIKS sample like Asian origins or the absence of current illicit drug use could explain, alone or in conjunction, the negative findings and suggest that there may be no dramatic volumetric or CT abnormalities in ARMS. PMID:25745033

  20. Spontaneous remission of acute myeloid leukemia relapse after hematopoietic cell transplantation in a high-risk patient with 11q23/MLL abnormality.

    PubMed

    Hudecek, Michael; Bartsch, Kristina; Jäkel, Nadja; Heyn, Simone; Pfannes, Roald; Al-Ali, Haifa Kathrin; Cross, Michael; Pönisch, Wolfram; Gerecke, Ulrich; Edelmann, Jeanett; Ittel, Thomas; Niederwieser, Dietger

    2008-01-01

    A 35-year-old female patient was diagnosed with acute myeloid leukemia with multiple genetic aberrations [48 XX, del(3)(q21), +6, t(11;15)(q23;q15), +21] including an 11q23/MLL abnormality. The patient achieved a complete remission after one induction chemotherapy cycle. After three courses of consolidation, a matched unrelated hematopoietic cell transplantation (HCT) was performed. Following an upper respiratory tract infection 7 years after transplant, her blood counts declined to leukocytes of 1 x 10(9)/l, platelets of 51 x 10(9)/l and hemoglobin of 7.5 g/dl. A bone marrow aspirate revealed 55% leukemic blasts carrying the unfavorable genetic aberrations seen at initial diagnosis (11q23/MLL). In the absence of any disease-specific treatment, the leukemic blasts cleared from the bone marrow within 6 days after diagnosis of relapse and peripheral blood counts returned to normal. Molecular analysis of the 11q23/MLL rearrangement was used to evaluate minimal residual disease, which became undetectable in repetitive FISH analyses. This is the first report of spontaneous remission in a patient with initially a multiaberrant leukemic cell clone and a proven 11q23/MLL abnormality at relapse after HCT. PMID:18367831

  1. Theory of viscous transonic flow over airfoils at high Reynolds number

    NASA Technical Reports Server (NTRS)

    Melnik, R. E.; Chow, R.; Mead, H. R.

    1977-01-01

    This paper considers viscous flows with unseparated turbulent boundary layers over two-dimensional airfoils at transonic speeds. Conventional theoretical methods are based on boundary layer formulations which do not account for the effect of the curved wake and static pressure variations across the boundary layer in the trailing edge region. In this investigation an extended viscous theory is developed that accounts for both effects. The theory is based on a rational analysis of the strong turbulent interaction at airfoil trailing edges. The method of matched asymptotic expansions is employed to develop formal series solutions of the full Reynolds equations in the limit of Reynolds numbers tending to infinity. Procedures are developed for combining the local trailing edge solution with numerical methods for solving the full potential flow and boundary layer equations. Theoretical results indicate that conventional boundary layer methods account for only about 50% of the viscous effect on lift, the remaining contribution arising from wake curvature and normal pressure gradient effects.

  2. Multi-element airfoil optimization for maximum lift at high Reynolds numbers

    NASA Technical Reports Server (NTRS)

    Valarezo, Walter O.; Dominik, Chet J.; Mcghee, Robert J.; Goodman, Wesley L.; Paschal, Keith B.

    1991-01-01

    An experimental study has been performed to assess the maximum lift capability of a supercritical multielement airfoil representative of an advanced transport aircraft wing. The airfoil model was designed with a leading-edge slat and single or two-segment trailing-edge flaps. Optimization work was performed at various slat/flap deflections as well as gap/overhang positions. Landing configurations and the attainment of maximum lift coefficients of 4.5 with single-element flaps and 5.0 with two-segment flaps was emphasized. Test results showed a relatively linear variation of the optimum gap/overhang positioning of the slat versus slat deflection, considerable differences in optimum rigging between single and double segment flaps, and large Reynolds number effects on multielement airfoil optimization.

  3. Tests of Full-Scale Helicopter Rotors at High Advancing Tip Mach Numbers and Advance Ratios

    NASA Technical Reports Server (NTRS)

    Biggers, James C.; McCloud, John L., III; Stroub, Robert H.

    2015-01-01

    As a continuation of the studies of reference 1, three full-scale helicopter rotors have been tested in the Ames Research Center 40- by SO-foot wind tunnel. All three of them were two-bladed, teetering rotors. One of the rotors incorporated the NACA 0012 airfoil section over the entire length of the blade. This rotor was tested at advance ratios up to 1.05. Both of the other rotors were tapered in thickness and incorporated leading-edge camber over the outer 20 percent of the blade radius. The larger of these rotors was tested at advancing tip Mach numbers up to 1.02. Data were obtained for a wide range of lift and propulsive force, and are presented without discussion.

  4. Large-Eddy Simulation of a High Reynolds Number Flow Around a Cylinder Including Aeroacoustic Predictions

    NASA Technical Reports Server (NTRS)

    Spyropoulos, Evangelos T.; Holmes, Bayard S.

    1997-01-01

    The dynamic subgrid-scale model is employed in large-eddy simulations of flow over a cylinder at a Reynolds number, based on the diameter of the cylinder, of 90,000. The Centric SPECTRUM(trademark) finite element solver is used for the analysis. The far field sound pressure is calculated from Lighthill-Curle's equation using the computed fluctuating pressure at the surface of the cylinder. The sound pressure level at a location 35 diameters away from the cylinder and at an angle of 90 deg with respect to the wake's downstream axis was found to have a peak value of approximately 110 db. Slightly smaller peak values were predicted at the 60 deg and 120 deg locations. A grid refinement study suggests that the dynamic model demands mesh refinement beyond that used here.

  5. Low Reynolds Number Biofilm Streamers Form as Highly Viscous Liquid Jets

    NASA Astrophysics Data System (ADS)

    Kumar, Aloke; Hassanpourfard, Mahtab; Das, Siddhartha

    2014-11-01

    There are recent experimental investigations that suggest that in presence of low Reynolds number (Re << 1) transport, preformed bacterial biofilms may deform into filamentous structures termed as streamers. Streamer formation time-scales usually far exceed reported rheological relaxation time scales for biofilms. Here we propose a theory that hypothesizes that streamers form due to the viscous response of the viscoelastic biofilms. The theoretical model is based on a stability analysis and can accurately explain hitherto unresolved issues, such as extremely large time needed for appearance of streamers and exponential growth of streamer dimensions after it has formed. We also provide results from our own initial experiments that indicate towards the validity of this ``liquid-state'' hypothesis.

  6. Abnormal ferrite in hyper-eutectoid steels

    SciTech Connect

    Chairuangsri, T.; Edmonds, D.V.

    2000-04-19

    The microstructural characteristics of ultra-high carbon hyper-eutectoid Fe-C and Fe-C-Cu experimental steels have been examined after isothermal transformation in a range just beneath the eutectoid temperature. Particular attention was paid to the formation of so-called abnormal ferrite, which refers to coarse ferrite grains which can form, in hyper-eutectoid compositions, on the pro-eutectoid cementite before the pearlite reaction occurs. Thus it is confirmed that the abnormal ferrite is not a result of pearlite coarsening, but of austenite decomposition before the conditions for coupled growth of pearlite are established. The abnormal ferrite formed on both allotriomorphic and Widmanstaetten forms of pro-eutectoid cementite, and significantly, it was observed that the pro-eutectoid cementite continued to grow, despite being enclosed by the abnormal ferrite. Under certain conditions this could lead to the eventual formation of substantially reduced amounts of pearlite. Thus, a model for carbon redistribution that allows the proeutectoid cementite to thicken concurrently with the abnormal ferrite is presented. The orientation relationships between the abnormal ferrite and pro-eutectoid cementite were also determined and found to be close to those which have been reported between pearlitic ferrite and pearlitic cementite.

  7. Prevalence of asymptomatic urinary abnormalities among adolescents.

    PubMed

    Fouad, Mohamed; Boraie, Maher

    2016-05-01

    To determine the prevalence of asymptomatic urinary abnormalities in adolescents, first morning clean mid-stream urine specimens were obtained from 2500 individuals and examined by dipstick and light microscopy. Adolescents with abnormal screening results were reexamined after two weeks and those who had abnormal results twice were subjected to systemic clinical examination and further clinical and laboratory investigations. Eight hundred and three (32.1%) individuals had urinary abnormalities at the first screening, which significantly decreased to 345 (13.8%) at the second screening, (P <0.001). Hematuria was the most common urinary abnormalities detected in 245 (9.8%) adolescents who had persistent urine abnormalities; 228 (9.1%) individuals had non glomerular hematuria. The hematuria was isolated in 150 (6%) individuals, combined with leukocyturia in 83 (3.3%) individuals, and combined with proteinuria in 12 (0.5%) individuals. Leukocyturia was detected in 150 (6%) of all studied adolescents; it was isolated in 39 (1.6%) individuals and combined with proteinuria in 28 (1.1%) of them. Asymptomatic bacteriuria was detected in 23 (0.9%) of all studied adolescents; all the cases were females. Proteinuria was detected in 65 (2.6%) of all the studied adolescents; 45 (1.8%) individuals had <0.5 g/day and twenty (0.8%) individuals had 0.5-3 g/day. Asymptomatic urinary abnormalities were more common in males than females and adolescents from rural than urban areas (P <0.01) and (P <0.001), respectively. The present study found a high prevalence of asymptomatic urinary abnormalities among adolescents in our population. PMID:27215241

  8. [Renal abnormalities in HIV infected patients].

    PubMed

    Pernasetti, María Marta; Chiurchiu, Carlos; Fuente, Jorge de la; Arteaga, Javier de; Douthat, Walter; Bardosy, Cecilia; Zarate, Abel; Massari, Pablo U

    2010-01-01

    Several renal complications may occur during HIV infection, especially in advanced stages related to HIV, to other infectious agents and/or drugs. Little is known about the prevalence of renal diseases that may occur as a complication of or related to HIV infection in asymptomatic patients. This is a single center cross-sectional study of asymptomatic HIV(+) patients referred to a nefrology care service at an Argentine hospital to look for the presence of renal abnormalities. Fifty two consecutive patients were studied between April and November 2008. Patients underwent plasma and urine analysis, ultrasound, and kidney biopsy as needed. Mean age was 39.9 +/- 10.6 years, 88% were male, time from HIV diagnosis 53.2 +/- 41.2 months (2-127); 71% had HIV-disease and 77% were on antiretroviral therapy. Mean plasma HIV-RNA copies number was 7.043 +/- 3.322 and CD4+ cell count: 484 +/- 39. Pathologic findings in urine analysis were present in 30.7% of patients: albuminuria 16.6%, microscopic hematuria 11.5%, hypercalciuria 10.8% and crystalluria 6%. Mean glomerular filtration rate was 102.2 +/- 22.95 ml/min (34-149) and 41% of patients could be classified in stages 1 to 3 of chronic kidney disease. Renal abnormalities prevaled in older patients without relationship with presence of HIV-disease. Two patients were biopsied and the findings included: tubulointerstitial nephritis with presence of crystal deposition in one and IgA nephropathy in the other. No HIV-associated nephropathy was detected. The broad spectrum and the high prevalence of lesions found in this series suggest that asymptomatic HIV-infected patients should routinely undergo renal evaluation. PMID:20529774

  9. Teacher-made Test Items in American History: Emphasis Junior High School. Bulletin Number 40.

    ERIC Educational Resources Information Center

    Kurfman, Dana

    Designed originally for use in junior-high-school classes, this bulletin provides an extensive file of 420 multiple-choice test questions in American history. The test items are intended to measure substantive understandings as well as such abilities as interpretation, analysis, synthesis, evaluation, and application. The initial questions were…

  10. The Danish Folk High Schools. Bulletin, 1914, No. 22. Whole Number 595

    ERIC Educational Resources Information Center

    Foght, H. W.

    1914-01-01

    This bulletin contains the third section of Harold W. Foght's report on the rural schools of Denmark. This section of the report pertains almost wholly to the folk high schools, which have by common consent been the most important factor in the transformation in the rural life of Denmark and in the phenomenal economic and social development of…

  11. Initial analysis of copy number variations in Holstein cattle selected for high or low feed efficiency

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Genomic structural variation is an important and abundant source of genetic and phenotypic variation. In this study, we performed an initial analysis of CNVs using BovineHD SNP genotyping data from 147 Holstein cattle selected for high or low feed efficiency. We detected 443 candidate CNV regions, w...

  12. Are Credit Card Rates Too High? At Home with Consumers. Volume 8, Number 1.

    ERIC Educational Resources Information Center

    At Home with Consumers, 1987

    1987-01-01

    The four articles in this journal issue examine the pros and cons of the proposition that credit card rates are too high. In "How Congress and Consumers Will Crack the Credit Card Market," Congressman Charles E. Schumer argues that banks can get away with their excessive rates because of consumer misinformation and the unfair competitive edge held…

  13. Middle School/Junior High Science. Focus on Excellence, Volume 2, Number 2.

    ERIC Educational Resources Information Center

    Penick, John E., Ed.; Krajcik, Joseph, Ed.

    Ten examples of innovative and outstanding middle school/junior high science programs are described. These programs were selected using state criteria and at least four independent reviewers. While Project Synthesis offered a desired state, these examples of excellence provided views of what is already a reality. The goals of an exemplary science…

  14. Is High School Economically Relevant for Noncollege Youth? Number 95-19.

    ERIC Educational Resources Information Center

    Stull, William J.

    A rational apathy (RAP) model has been proposed that divides high school students into groups that face different sets of short-term rewards for school involvement. Students bound for competitive and less competitive colleges make up the first two groups, but those who do not intend to pursue higher education are the third group. The RAP model…

  15. Turbulent secondary flows in high Reynolds number boundary layers induced by streamwise-elongated complex roughness

    NASA Astrophysics Data System (ADS)

    Anderson, William; Barros, Julio; Christensen, Kenneth

    2014-11-01

    It has been reported that complex roughness with a predominant streamwise elongation induces secondary mean flow heterogeneities in the above turbulent boundary layer (Mejia-Alvarez and Christensen, Phys. Fluids 25, 115 (2013), MAC; Nugroho et al., Int. J. Heat Fluid Flow 41, 90 (2013)). These mean secondary flows exist as transverse variations of mean streamwise velocity (so-called low- and high-momentum pathways, MAC) and are flanked by mean counter-rotating, boundary layer-scale circulations (Christensen and Barros, J. Fluid Mech. 748, R1 (2014)). In related work, we have used large-eddy simulation to model turbulent boundary layer flow over a suite of topographies composed of ``strips'' of high and low roughness length (drag imposed with the equilibrium logarithmic law); in all cases, we observe the formation of high- and low-momentum pathways (Willingham et al., Phys. Fluids 26, 025111 (2013)). Here, we investigate turbulence statistics from large-eddy simulation such as magnitudes and spatial gradients of Reynolds stresses and turbulence kinetic energy, to discern underlying physical processes responsible for the secondary flows. We demonstrate that elevated production of turbulence above ``high'' roughness necessitates the mean circulations by virtue of turbulent kinetic energy production-dissipation non-equilibrium. We propose that the mean flow is Prandtl's secondary flow of the second kind.

  16. High number of diarrhoeal co-infections in travellers to Benin, West Africa

    PubMed Central

    2014-01-01

    Background Travellers’ diarrhoea (TD) is the most frequent health problem among travellers to the tropics. Using routine techniques, the aetiology mostly remains unresolved, whereas modern molecular methods enable reducing the number of equivocal cases considerably. While many studies address the aetiology of TD in Asian, Central American and North African tourist resorts, only few focus on Western Africa. Methods Stool samples from 45 travellers travelling in Benin, West Africa, were analyzed by a new multiplex qPCR assay for Salmonella, Yersinia, Campylobacter, Vibrio cholerae, Shigella or enteroinvasive (EIEC), enterohaemorrhagic (EHEC), enterotoxigenic (ETEC), enteroaggregative (EAEC), and enteropathogenic Escherichia coli (EPEC). Results All 18 pre-travel samples proved negative for bacterial pathogens. Of the 39/45 (87%) travellers having had TD, EPEC was detected in post-travel samples in 30 (77%) cases, EAEC in 23 (59%), ETEC in 22 (56%), Shigella or EIEC in 7 (18%), EHEC in two (5%), and Salmonella in one (3%). In 31(79%) of the TD cases two or more bacterial pathogens were identified. Two (8%) samples remained negative: both patients had taken antimicrobials for TD. Conclusions EPEC, EAEC and ETEC were the most common findings. 79% of the cases had a co-infection. As modern diagnostics reveals in most patients a multitude of pathogens, the role of each pathogen should be re-evaluated. PMID:24521079

  17. Backward two-particle dispersion in turbulence: asymptotic behaviors at high Reynolds number

    NASA Astrophysics Data System (ADS)

    Yeung, Pui-Kuen; Buaria, D.; Sawford, B. L.

    2015-11-01

    Backward relative dispersion of fluid elements and diffusing substances or property markers is central to a Lagrangian view of turbulent mixing, but data are not readily available. Recently we have devised a numerical approach based on massively parallel processing of the trajectories of many billions of particle pairs, and have used it to obtain results in simulations of stationary isotropic turbulence up to 4096 in size and Taylor-scale Reynolds number up to 1000, with a wide range of initial separations. Backward dispersion is faster than forward, especially at intermediate times after the ballistic range and before long-time diffusive behavior is reached. Richardson scaling is demonstrated for the mean-squared separation, with forward and backward Richardson constants estimated to be 0.55 and 1.5 respectively, which are close to or comparable to other estimates. However, because of persistent dissipation sub-range effects no corresponding scaling was observed for higher order moments. An effort is made to analyze theoretically several key characteristics such as asymmetry in time and exponential growth of third and fourth moments at early times. Related results for marked entities that diffuse relative to the fluid will also be briefly addressed. Supported by NSF Grant CBET-1039037 (Fluid Dynamics Program).

  18. Subtle Changes to Peripheral Ligands Enable High Turnover Numbers for Photocatalytic Hydrogen Generation with Supramolecular Photocatalysts.

    PubMed

    Kowacs, Tanja; O'Reilly, Laura; Pan, Qing; Huijser, Annemarie; Lang, Philipp; Rau, Sven; Browne, Wesley R; Pryce, Mary T; Vos, Johannes G

    2016-03-21

    The photocatalytic generation of hydrogen (H2) from protons by two cyclometalated ruthenium-platinum polypyridyl complexes, [Ru(bpy)2(2,5-bpp)PtIS](2+) (1) and [Ru(dceb)2(2,5-bpp)PtIS](2+) (2) [where bpy = 2,2'-bipyridine, 2,5-bpp = 2,2',5',2″-terpyridine, dceb = 4,4'-di(carboxyethyl)bipyridine, and S = solvent], is reported. Turnover numbers (TONs) for H2 generation were increased by nearly an order of magnitude by the introduction of carboxyethyl ester units, i.e., from 80 for 1P to 650 for 2P after 6 h of irradiation, with an early turnover frequency (TOF) increasing from 15 to 200 h(-1). The TON and TOF values for 2P are among the highest reported to date for supramolecular photocatalysts. The increase correlates with stabilization of the excited states localized on the peripheral ligands of the light-harvesting Ru(II) center. PMID:26925834

  19. Nonlinear effects on sound propagation through high subsonic Mach number flows in variable area ducts

    NASA Technical Reports Server (NTRS)

    Callegari, A. J.

    1979-01-01

    A nonlinear theory for sound propagation in variable area ducts carrying a nearly sonic flow is presented. Linear acoustic theory is shown to be singular and the detailed nature of the singularity is used to develop the correct nonlinear theory. The theory is based on a quasi-one dimensional model. It is derived by the method of matched asymptotic expansions. In a nearly chocked flow, the theory indicates the following processes to be acting: a transonic trapping of upstream propagating sound causing an intensification of this sound in the throat region of the duct; generation of superharmonics and an acoustic streaming effect; development of shocks in the acoustic quantities near the throat. Several specific problems are solved analytically and numerical parameter studies are carried out. Results indicate that appreciable acoustic power is shifted to higher harmonics as shocked conditions are approached. The effect of the throat Mach number on the attenuation of upstream propagating sound excited by a fixed source is also determined.

  20. Inertial Particle Relative Velocity in a High-Reynolds-Number Homogeneous and Isotropic Turbulence Chamber

    NASA Astrophysics Data System (ADS)

    Dou, Zhongwang; Pecenak, Zachary; Liang, Zach; Cao, Lujie; Ireland, Peter; Collins, Lance; Meng, Hui

    2015-11-01

    Particle-pair radial relative velocity (RV) in turbulence plays a critical role in droplet collision and cloud formation. Both simulations and experiments are performed to better understand RV of inertial particles in homogeneous and isotropic turbulence (HIT). However, past experimental measurement of particle RV statistics exhibited large deviations from DNS results (de Jong et al., 2010). In the current study, we identified intrinsic limitations in our previous study and devised a 4-frame particle tracking velocimetry technique to measure particle RV. In a second-generation, enclosed, fan-driven HIT chamber, both tracer and inertial particles were studied at R_ λ of 366. The experimentally measured RV statistics were compared with DNS with excellent agreement. Additionally, for both kinds of particles, the mean inward RV vs. particle separation distance r also matched very well with DNS, but at near-zero r, experimental values were slightly higher. To investigate the cause of this discrepancy, we compared DNS of both mono- and tri-dispersed particles. We found that the tri-dispersed particles exhibited higher mean inward RV at small r than any mono-dispersed particles. This suggests that the increase of mean inward RV in the experiment could be due to the Stokes number (St) distribution present in the particles, while DNS employed single St values. This work was supported by the National Science Foundation through a Collaborative Research Grant CBET-0967407.