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Sample records for abnormally high plasma

  1. Erythrocyte echinocytosis in liver disease. Role of abnormal plasma high density lipoproteins.

    PubMed Central

    Owen, J S; Brown, D J; Harry, D S; McIntyre, N; Beaven, G H; Isenberg, H; Gratzer, W B

    1985-01-01

    Echinocytes were frequently found in patients with liver disease when their blood was examined in wet films, but rarely detected in dried, stained smears. When normal erythrocytes (discocytes) were incubated with physiologic concentrations of the abnormal high density lipoproteins (HDL) from some jaundiced patients, echinocytosis developed within seconds. Other plasma fractions were not echinocytogenic. There was a close correlation between the number of echinocytes found in vivo and the ability of the corresponding HDL to induce discocyte-echinocyte transformation. On incubation with normal HDL, echinocytes generated in vitro rapidly reverted to a normal shape, and echinocytes from patients showed a similar trend. Echinocytosis occurred without change in membrane cholesterol content, as did its reversal, and was not caused by membrane uptake of lysolecithin or bile acids. Abnormal, echinocytogenic HDL showed saturable binding to approximately 5,000 sites per normal erythrocyte with an association constant of 10(8) M-1. Nonechinocytogenic patient HDL and normal HDL showed only nonsaturable binding. Several minor components of electrophoretically separated erythrocyte membrane proteins bound the abnormal HDL; pretreatment of the cells with trypsin or pronase reduced or eliminated binding. Echinocytosis by abnormal HDL required receptor occupancy, rather than transfer of constituents to or from the membrane, because cells reversibly prefixed in the discoid shape by wheat germ agglutinin, and then exposed to abnormal HDL, did not become echinocytes when the HDL and lectin were successively removed. Binding did not cause dephosphorylation of spectrin. We conclude that the echinocytes of liver disease are generated from discocytes by abnormal HDL, and we infer that the shape change is mediated by cell-surface receptors for abnormal HDL molecules. Images PMID:4077979

  2. Normal and abnormal evolution of argon metastable density in high-density plasmas

    SciTech Connect

    Seo, B. H.; Kim, J. H.; You, S. J.

    2015-05-15

    A controversial problem on the evolution of Ar metastable density as a function of electron density (increasing trend versus decreasing trend) was resolved by discovering the anomalous evolution of the argon metastable density with increasing electron density (discharge power), including both trends of the metastable density [Daltrini et al., Appl. Phys. Lett. 92, 061504 (2008)]. Later, by virtue of an adequate physical explanation based on a simple global model, both evolutions of the metastable density were comprehensively understood as part of the abnormal evolution occurring at low- and high-density regimes, respectively, and thus the physics behind the metastable evolution has seemed to be clearly disclosed. In this study, however, a remarkable result for the metastable density behavior with increasing electron density was observed: even in the same electron density regime, there are both normal and abnormal evolutions of metastable-state density with electron density depending on the measurement position: The metastable density increases with increasing electron density at a position far from the inductively coupled plasma antenna but decreases at a position close to the antenna. The effect of electron temperature, which is spatially nonuniform in the plasma, on the electron population and depopulation processes of Argon metastable atoms with increasing electron density is a clue to understanding the results. The calculated results of the global model, including multistep ionization for the argon metastable state and measured electron temperature, are in a good agreement with the experimental results.

  3. Abnormal high density lipoproteins in cerebrotendinous xanthomatosis

    SciTech Connect

    Shore, V.; Salen, G.; Cheng, F.W.; Forte, T.; Shefer, S.; Tint, G.S.

    1981-11-01

    The plasma lipoprotein profiles and high density lipoproteins (HDL) were characterized in patients with the genetic disease cerebrotendinous xanthomatosis (CTX). The mean HDL-cholesterol concentration in the CTX plasmas was 14.5 +/- 3.2 mg/dl, about one-third the normal value. The low HDL-cholesterol reflects a low concentration and an abnormal lipid composition of the plasma HDL. Relative to normal HDL, the cholesteryl esters are low, free cholesterol and phospholipids essentially normal, and triglycerides increased. The ratio of apoprotein (apo) to total cholesterol in the HDL of CTX was two to three times greater than normal. In the CTX HDL, the ratio of apoAI to apoAII was high, the proportion of apoC low, and a normally minor form of apoAI increased relative to other forms. The HDL in electron micrographs appeared normal morphologically and in particle size. The adnormalities in lipoprotein distribution profiles and composition of the plasma HDL result from metabolic defects that are not understood but may be linked to the genetic defect in bile acid synthesis in CTX. As a consequence, it is probable that the normal functions of the HDL, possibly including modulation of LDL-cholesterol uptake and the removal of excess cholesterol from peripheral tissues, are perturbed significantly in this disease.

  4. Abnormally high formation pressures, Potwar Plateau, Pakistan

    USGS Publications Warehouse

    Law, B.E.; Shah, S.H.A.; Malik, M.A.

    1998-01-01

    Abnormally high formation pressures in the Potwar Plateau of north-central Pakistan are major obstacles to oil and gas exploration. Severe drilling problems associated with high pressures have, in some cases, prevented adequate evaluation of reservoirs and significantly increased drilling costs. Previous investigations of abnormal pressure in the Potwar Plateau have only identified abnormal pressures in Neogene rocks. We have identified two distinct pressure regimes in this Himalayan foreland fold and thrust belt basin: one in Neogene rocks and another in pre-Neogene rocks. Pore pressures in Neogene rocks are as high as lithostatic and are interpreted to be due to tectonic compression and compaction disequilibrium associated with high rates of sedimentation. Pore pressure gradients in pre-Neogene rocks are generally less than those in Neogene rocks, commonly ranging from 0.5 to 0.7 psi/ft (11.3 to 15.8 kPa/m) and are most likely due to a combination of tectonic compression and hydrocarbon generation. The top of abnormally high pressure is highly variable and doesn't appear to be related to any specific lithologic seal. Consequently, attempts to predict the depth to the top of overpressure prior to drilling are precluded.

  5. Association of abnormal plasma bilirubin with aggressive hepatocellular carcinoma phenotype.

    PubMed

    Carr, Brian I; Guerra, Vito; Giannini, Edoardo G; Farinati, Fabio; Ciccarese, Francesca; Ludovico Rapaccini, Gian; Di Marco, Maria; Benvegnù, Luisa; Zoli, Marco; Borzio, Franco; Caturelli, Eugenio; Chiaramonte, Maria; Trevisani, Franco

    2014-04-01

    Cirrhosis-related abnormal liver function is associated with predisposition to hepatocellular carcinoma (HCC). It features in several HCC classification systems and is an HCC prognostic factor. The aim of the present study was to examine the phenotypic tumor differences in HCC patients with normal or abnormal plasma bilirubin levels. A 2,416-patient HCC cohort was studied and dichotomized into normal and abnormal plasma bilirubin groups. Their HCC characteristics were compared for tumor aggressiveness features, namely, blood alpha-fetoprotein (AFP) levels, tumor size, presence of portal vein thrombosis (PVT) and tumor multifocality. In the total cohort, elevated bilirubin levels were associated with higher AFP levels, increased PVT and multifocality, and lower survival, despite similar tumor sizes. When different tumor size terciles were compared, similar results were found, even among patients with small tumors. A multiple logistic regression model for PVT or tumor multifocality showed increased odds ratios for elevated levels of gamma glutamyl transpeptidase (GGTP), bilirubin, and AFP and for larger tumor sizes. We conclude that HCC patients with abnormal bilirubin levels had worse prognosis than patients with normal bilirubin. They also had an increased incidence of PVT and tumor multifocality, and higher AFP levels, in patients with both small and larger tumors. The results show an association between bilirubin levels and indices of HCC aggressiveness. PMID:24787296

  6. Plasma concentrations of endothelin in patients with abnormal vascular reactivity

    SciTech Connect

    Predel, H.G.; Meyer-Lehnert, H.; Baecker, A.; Stelkens, H.; Kramer, H.J. )

    1990-01-01

    We measured circulating concentrations of endothelin in healthy subjects and in patients with abnormal vascular reactivity. Endothelin concentrations were determined by radioimmunoassay after extraction of plasma using Sep-Pak C-18 cartridges in healthy subjects, in patients with diabetes mellitus type I, in patients with mild to moderate essential hypertension and in non-dialyzed patients with stable chronic renal failure. Plasma concentrations were similar in healthy controls, in diabetics and in hypertensive patients averaging 5.0{plus minus}0.6 pg/ml, 4.7{plus minus}0.2 pg/ml and 6.5{plus minus}1.0 pg/ml, respectively. In contrast, plasma concentrations of endothelin were markedly elevated in patients with chronic renal failure averaging 16.6{plus minus}2.9 pg/ml. No correlations were observed between serum creatinine concentrations ranging from 124 to 850 {mu}mol/l or blood pressure and plasma concentrations of endothelin. Bicycle ergometric exercise in six healthy subjects and an acute modest i.v. saline load of 1,000 ml of 0.45% NaCl administered within 60 min in six patients with mild essential hypertension did not affect plasma concentrations of endothelin.

  7. Noninvasive detection of fetal subchromosomal abnormalities by semiconductor sequencing of maternal plasma DNA.

    PubMed

    Yin, Ai-hua; Peng, Chun-fang; Zhao, Xin; Caughey, Bennett A; Yang, Jie-xia; Liu, Jian; Huang, Wei-wei; Liu, Chang; Luo, Dong-hong; Liu, Hai-liang; Chen, Yang-yi; Wu, Jing; Hou, Rui; Zhang, Mindy; Ai, Michael; Zheng, Lianghong; Xue, Rachel Q; Mai, Ming-qin; Guo, Fang-fang; Qi, Yi-ming; Wang, Dong-mei; Krawczyk, Michal; Zhang, Daniel; Wang, Yu-nan; Huang, Quan-fei; Karin, Michael; Zhang, Kang

    2015-11-24

    Noninvasive prenatal testing (NIPT) using sequencing of fetal cell-free DNA from maternal plasma has enabled accurate prenatal diagnosis of aneuploidy and become increasingly accepted in clinical practice. We investigated whether NIPT using semiconductor sequencing platform (SSP) could reliably detect subchromosomal deletions/duplications in women carrying high-risk fetuses. We first showed that increasing concentration of abnormal DNA and sequencing depth improved detection. Subsequently, we analyzed plasma from 1,456 pregnant women to develop a method for estimating fetal DNA concentration based on the size distribution of DNA fragments. Finally, we collected plasma from 1,476 pregnant women with fetal structural abnormalities detected on ultrasound who also underwent an invasive diagnostic procedure. We used SSP of maternal plasma DNA to detect subchromosomal abnormalities and validated our results with array comparative genomic hybridization (aCGH). With 3.5 million reads, SSP detected 56 of 78 (71.8%) subchromosomal abnormalities detected by aCGH. With increased sequencing depth up to 10 million reads and restriction of the size of abnormalities to more than 1 Mb, sensitivity improved to 69 of 73 (94.5%). Of 55 false-positive samples, 35 were caused by deletions/duplications present in maternal DNA, indicating the necessity of a validation test to exclude maternal karyotype abnormalities. This study shows that detection of fetal subchromosomal abnormalities is a viable extension of NIPT based on SSP. Although we focused on the application of cell-free DNA sequencing for NIPT, we believe that this method has broader applications for genetic diagnosis, such as analysis of circulating tumor DNA for detection of cancer. PMID:26554006

  8. Noninvasive detection of fetal subchromosomal abnormalities by semiconductor sequencing of maternal plasma DNA

    PubMed Central

    Yin, Ai-hua; Peng, Chun-fang; Zhao, Xin; Caughey, Bennett A.; Yang, Jie-xia; Liu, Jian; Huang, Wei-wei; Liu, Chang; Luo, Dong-hong; Liu, Hai-liang; Chen, Yang-yi; Wu, Jing; Hou, Rui; Zhang, Mindy; Ai, Michael; Zheng, Lianghong; Xue, Rachel Q.; Mai, Ming-qin; Guo, Fang-fang; Qi, Yi-ming; Wang, Dong-mei; Krawczyk, Michal; Zhang, Daniel; Wang, Yu-nan; Huang, Quan-fei; Karin, Michael; Zhang, Kang

    2015-01-01

    Noninvasive prenatal testing (NIPT) using sequencing of fetal cell-free DNA from maternal plasma has enabled accurate prenatal diagnosis of aneuploidy and become increasingly accepted in clinical practice. We investigated whether NIPT using semiconductor sequencing platform (SSP) could reliably detect subchromosomal deletions/duplications in women carrying high-risk fetuses. We first showed that increasing concentration of abnormal DNA and sequencing depth improved detection. Subsequently, we analyzed plasma from 1,456 pregnant women to develop a method for estimating fetal DNA concentration based on the size distribution of DNA fragments. Finally, we collected plasma from 1,476 pregnant women with fetal structural abnormalities detected on ultrasound who also underwent an invasive diagnostic procedure. We used SSP of maternal plasma DNA to detect subchromosomal abnormalities and validated our results with array comparative genomic hybridization (aCGH). With 3.5 million reads, SSP detected 56 of 78 (71.8%) subchromosomal abnormalities detected by aCGH. With increased sequencing depth up to 10 million reads and restriction of the size of abnormalities to more than 1 Mb, sensitivity improved to 69 of 73 (94.5%). Of 55 false-positive samples, 35 were caused by deletions/duplications present in maternal DNA, indicating the necessity of a validation test to exclude maternal karyotype abnormalities. This study shows that detection of fetal subchromosomal abnormalities is a viable extension of NIPT based on SSP. Although we focused on the application of cell-free DNA sequencing for NIPT, we believe that this method has broader applications for genetic diagnosis, such as analysis of circulating tumor DNA for detection of cancer. PMID:26554006

  9. Plasma transfusions prior to insertion of central lines for patients with abnormal coagulation

    PubMed Central

    Hall, David P; Estcourt, Lise J; Doree, Carolyn; Hopewell, Sally; Trivella, Marialena; Walsh, Timothy S

    2015-01-01

    This is the protocol for a review and there is no abstract. The objectives are as follows: To assess the effect of different prophylactic plasma transfusion regimens prior to central line insertion in patients with abnormal coagulation. PMID:27057149

  10. High energy plasma accelerators

    SciTech Connect

    Tajima, T.

    1985-05-01

    Colinear intense laser beams ..omega../sub 0/, kappa/sub 0/ and ..omega../sub 1/, kappa/sub 1/ shone on a plasma with frequency separation equal to the electron plasma frequency ..omega../sub pe/ are capable of creating a coherent large longitudinal electric field E/sub L/ = mc ..omega../sub pe//e of the order of 1GeV/cm for a plasma density of 10/sup 18/ cm/sup -3/ through the laser beat excitation of plasma oscillations. Accompanying favorable and deleterious physical effects using this process for a high energy beat-wave accelerator are discussed: the longitudinal dephasing, pump depletion, the transverse laser diffraction, plasma turbulence effects, self-steepening, self-focusing, etc. The basic equation, the driven nonlinear Schroedinger equation, is derived to describe this system. Advanced accelerator concepts to overcome some of these problems are proposed, including the plasma fiber accelerator of various variations. An advanced laser architecture suitable for the beat-wave accelerator is suggested. Accelerator physics issues such as the luminosity are discussed. Applications of the present process to the current drive in a plasma and to the excitation of collective oscillations within nuclei are also discussed.

  11. Burden of cytogenetically abnormal plasma cells in light chain amyloidosis and their prognostic relevance.

    PubMed

    Kim, Seon Young; Im, Kyongok; Park, Si Nae; Kim, Jung-Ah; Yoon, Sung-Soo; Lee, Dong Soon

    2016-05-01

    We performed cytoplasmic fluorescence in situ hybridization assays of light chain amyloidosis (AL). In total, 234 patients were enrolled: 28 patients with AL, 24 with monoclonal gammopathy of undetermined significance (MGUS), and 182 with multiple myeloma (MM). Chromosomal abnormalities were detected in 13 of 22 (59%) AL patients without MM. All 13 patients demonstrated IGH rearrangement, and t(11;14)/IGH-CCND1 was most frequent (32%). Chromosome gain was not observed in AL patients without MM. These findings were dissimilar to findings in MGUS patients, in whom trisomy 9 was the most frequent abnormality. Of 6 AL patients with MM, 5 (83%) patients had cytogenetic abnormalities: 1q gain (4/6, 67%), gains of chromosome 9 (3/6, 50%), IGH rearrangement and RB1 (13q) deletions (2/6 each, 33%). The percentage of clonal plasma cells among total plasma cells was variable (median, 75%; range, 16-100%) for AL patients without MM, which was lower than the results for MM patients (median 100%). The overall survival of AL patients without MM was not significantly different according to the presence of cytogenetic abnormalities (P=0.510). In summary, among Korean AL patients, IGH rearrangement was the most frequent cytogenetic abnormality and cytogenetic aberration patterns differ compared with MGUS and MM patients. PMID:27015231

  12. High incidence of MYC and BCL2 abnormalities in mantle cell lymphoma, although only MYC abnormality predicts poor survival

    PubMed Central

    Li, Chengwen; Zhong, Shizhen; Chen, Weiwei; Li, Zengjun; Xiong, Wenjie; Liu, Wei; Liu, Enbin; Cui, Rui; Ru, Kun; Zhang, Peihong; Xu, Yan; An, Gang; Lv, Rui; Qi, Junyuan; Wang, Jianxiang; Cheng, Tao; Qiu, Lugui

    2015-01-01

    The incidence and prognostic role of MYC and BCL2 rearrangements in mature B-cell lymphomas have been extensively studied, except the infrequent mantle cell lymphoma (MCL). Here, we analyzed the MYC and BCL2 abnormalities and other cytogenetic aberrations by fluorescence in situ hybridization (FISH) in 50 MCL patients with bone marrow involvement. Eighteen patients (36.0%) had MYC gains and/or amplifications, and twelve patients (24.0%) had BCL2 gains and/or amplifications. Among the 18 patients with MYC abnormality, four had simultaneous MYC translocations, but no BCL2 translocation was detected among patients with BCL2 abnormality. Only two patients (4.0%) had both MYC and BCL2 abnormalities. The patients with a MYC abnormality had a significantly higher tumor burden, a higher percentage of medium/high risk MIPI group and genomic instability compared to those without this abnormality. However, no significant difference was observed between patients with or without a BCL2 abnormality in terms of clinical and cytogenetic factors. Patients with a MYC abnormality had poorer progress-free survival (PFS) (9.0 vs. 48.0 months, p = .000) and overall survival (OS) (12.0 vs. 94.5 months, p = .000), but the presence of a BCL2 abnormality did not significantly influence either PFS or OS. In multivariate analysis, the MYC abnormality was the independent adverse factor for both PFS and OS, and intensive chemotherapy did not improve the outcome of these patients. Thus, the presence of a MYC but not BCL2 abnormality predicted the poor survival of MCL patients, and a new treatment strategy should be developed for these patients. PMID:26517511

  13. Choroideremia Is a Systemic Disease With Lymphocyte Crystals and Plasma Lipid and RBC Membrane Abnormalities

    PubMed Central

    Zhang, Alice Yang; Mysore, Naveen; Vali, Hojatollah; Koenekoop, Jamie; Cao, Sang Ni; Li, Shen; Ren, Huanan; Keser, Vafa; Lopez-Solache, Irma; Siddiqui, Sorath Noorani; Khan, Ayesha; Mui, Jeannie; Sears, Kelly; Dixon, Jim; Schwartzentruber, Jeremy; Majewski, Jacek; Braverman, Nancy; Koenekoop, Robert K.

    2015-01-01

    Purpose Photoreceptor neuronal degenerations are common, incurable causes of human blindness affecting 1 in 2000 patients worldwide. Only half of all patients are associated with known mutations in over 250 disease genes, prompting our research program to identify the remaining new genes. Most retinal degenerations are restricted to the retina, but photoreceptor degenerations can also be found in a wide variety of systemic diseases. We identified an X-linked family from Sri Lanka with a severe choroidal degeneration and postulated a new disease entity. Because of phenotypic overlaps with Bietti's crystalline dystrophy, which was recently found to have systemic features, we hypothesized that a systemic disease may be present in this new disease as well. Methods For phenotyping, we performed detailed eye exams with in vivo retinal imaging by optical coherence tomography. For genotyping, we performed whole exome sequencing, followed by Sanger sequencing confirmations and cosegregation. Systemic investigations included electron microscopy studies of peripheral blood cells in patients and in normal controls and detailed fatty acid profiles (both plasma and red blood cell [RBC] membranes). Fatty acid levels were compared to normal controls, and only values two standard deviations above or below normal controls were further evaluated. Results The family segregated a REP1 mutation, suggesting choroideremia (CHM). We then found crystals in peripheral blood lymphocytes and discovered significant plasma fatty acid abnormalities and RBC membrane abnormalities (i.e., elevated plasmalogens). To replicate our discoveries, we expanded the cohort to nine CHM patients, genotyped them for REP1 mutations, and found the same abnormalities (crystals and fatty acid abnormalities) in all patients. Conclusions Previously, CHM was thought to be restricted to the retina. We show, to our knowledge for the first time, that CHM is a systemic condition with prominent crystals in lymphocytes and

  14. High-temperature plasma physics

    SciTech Connect

    Furth, H.P.

    1988-03-01

    Both magnetic and inertial confinement research are entering the plasma parameter range of fusion reactor interest. This paper reviews the individual and common technical problems of these two approaches to the generation of thermonuclear plasmas, and describes some related applications of high-temperature plasma physics.

  15. High Prevalence of Prothrombotic Abnormalities in Multifocal Osteonecrosis

    PubMed Central

    Peris, Pilar; Reverter, Joan Carles; Espinosa, Gerard; Martinez-Ferrer, Angeles; Monegal, Ana; Monteagudo, Juan; Tàssies, Dolors; Guañabens, Nuria

    2013-01-01

    Abstract Multifocal or multiple osteonecrosis (ON), defined by the involvement of 3 or more anatomic sites, is unusual, being observed in only 3%–10% of patients diagnosed with ON. We report the clinical characteristics of a cohort of 29 patients with multifocal ON from a single center and evaluate the prevalence of associated prothrombotic abnormalities in 26 of these patients. We conducted a retrospective study of all patients diagnosed with multifocal ON evaluated in our institution during the last 20 years. We recorded clinical manifestations and underlying diagnoses. A wide thrombophilic profile was performed, including antithrombin, protein C, protein S, lupus anticoagulant, anticardiolipin antibodies, activated protein C resistance, factor V Leiden, mutation G-20210-A of the prothrombin gene, and factor VIII. Coagulation test results were compared with those in a healthy control group and a group of patients with history of lower-extremity deep venous thrombosis. The mean age of the patients was 49.2 ± 15 years (range, 28–81 yr). The mean number of ON localizations per patient was 5.2 ± 2.3 (range, 3–11). Hips were the most commonly affected joint (82%), followed by knees (58%), shoulders (37%), and ankles (13%). Most patients had an underlying disease process, and 12 of 25 (48%) patients had coagulation test abnormalities. The most common alterations were high factor VIII levels and antiphospholipid antibody (aPL) positivity in 24% and 20% of cases, respectively. These abnormalities were more prevalent in patients with multifocal ON compared with patients in the control groups. Sixty-one percent of patients had a history of corticosteroid treatment. Patients with coagulation abnormalities had a higher number of ON localizations per patient (6.5 ± 2.7 vs. 3.88 ± 0.8; p = 0.002) and a higher prevalence of atypical ON localizations (25% vs. 0%; p = 0.05). In conclusion, in the present cohort of patients with multifocal ON, 48% of the patients had at

  16. Plasma genetic and genomic abnormalities predict treatment response and clinical outcome in advanced prostate cancer.

    PubMed

    Xia, Shu; Kohli, Manish; Du, Meijun; Dittmar, Rachel L; Lee, Adam; Nandy, Debashis; Yuan, Tiezheng; Guo, Yongchen; Wang, Yuan; Tschannen, Michael R; Worthey, Elizabeth; Jacob, Howard; See, William; Kilari, Deepak; Wang, Xuexia; Hovey, Raymond L; Huang, Chiang-Ching; Wang, Liang

    2015-06-30

    Liquid biopsies, examinations of tumor components in body fluids, have shown promise for predicting clinical outcomes. To evaluate tumor-associated genomic and genetic variations in plasma cell-free DNA (cfDNA) and their associations with treatment response and overall survival, we applied whole genome and targeted sequencing to examine the plasma cfDNAs derived from 20 patients with advanced prostate cancer. Sequencing-based genomic abnormality analysis revealed locus-specific gains or losses that were common in prostate cancer, such as 8q gains, AR amplifications, PTEN losses and TMPRSS2-ERG fusions. To estimate tumor burden in cfDNA, we developed a Plasma Genomic Abnormality (PGA) score by summing the most significant copy number variations. Cox regression analysis showed that PGA scores were significantly associated with overall survival (p < 0.04). After androgen deprivation therapy or chemotherapy, targeted sequencing showed significant mutational profile changes in genes involved in androgen biosynthesis, AR activation, DNA repair, and chemotherapy resistance. These changes may reflect the dynamic evolution of heterozygous tumor populations in response to these treatments. These results strongly support the feasibility of using non-invasive liquid biopsies as potential tools to study biological mechanisms underlying therapy-specific resistance and to predict disease progression in advanced prostate cancer. PMID:25915538

  17. Plasma genetic and genomic abnormalities predict treatment response and clinical outcome in advanced prostate cancer

    PubMed Central

    Du, Meijun; Dittmar, Rachel L.; Lee, Adam; Nandy, Debashis; Yuan, Tiezheng; Guo, Yongchen; Wang, Yuan; Tschannen, Michael R.; Worthey, Elizabeth; Jacob, Howard; See, William; Kilari, Deepak; Wang, Xuexia; Hovey, Raymond L.; Huang, Chiang-Ching; Wang, Liang

    2015-01-01

    Liquid biopsies, examinations of tumor components in body fluids, have shown promise for predicting clinical outcomes. To evaluate tumor-associated genomic and genetic variations in plasma cell-free DNA (cfDNA) and their associations with treatment response and overall survival, we applied whole genome and targeted sequencing to examine the plasma cfDNAs derived from 20 patients with advanced prostate cancer. Sequencing-based genomic abnormality analysis revealed locus-specific gains or losses that were common in prostate cancer, such as 8q gains, AR amplifications, PTEN losses and TMPRSS2-ERG fusions. To estimate tumor burden in cfDNA, we developed a Plasma Genomic Abnormality (PGA) score by summing the most significant copy number variations. Cox regression analysis showed that PGA scores were significantly associated with overall survival (p < 0.04). After androgen deprivation therapy or chemotherapy, targeted sequencing showed significant mutational profile changes in genes involved in androgen biosynthesis, AR activation, DNA repair, and chemotherapy resistance. These changes may reflect the dynamic evolution of heterozygous tumor populations in response to these treatments. These results strongly support the feasibility of using non-invasive liquid biopsies as potential tools to study biological mechanisms underlying therapy-specific resistance and to predict disease progression in advanced prostate cancer. PMID:25915538

  18. Correlation of plasma nitrite/nitrate levels and inducible nitric oxide gene expression among women with cervical abnormalities and cancer.

    PubMed

    Sowjanya, A Pavani; Rao, Meera; Vedantham, Haripriya; Kalpana, Basany; Poli, Usha Rani; Marks, Morgan A; Sujatha, M

    2016-01-30

    Cervical cancer is caused by infection with high risk human papillomavirus (HR-HPV). Inducible nitric oxide synthase (iNOS), a soluble factor involved in chronic inflammation, may modulate cervical cancer risk among HPV infected women. The aim of the study was to measure and correlate plasma nitrite/nitrate levels with tissue specific expression of iNOS mRNA among women with different grades of cervical lesions and cervical cancer. Tissue biopsy and plasma specimens were collected from 120 women with cervical neoplasia or cancer (ASCUS, LSIL, HSIL and invasive cancer) and 35 women without cervical abnormalities. Inducible nitric oxide synthase (iNOS) mRNA from biopsy and plasma nitrite/nitrate levels of the same study subjects were measured. Single nucleotide polymorphism (SNP) analysis was performed on the promoter region and Ser608Leu (rs2297518) in exon 16 of the iNOS gene. Differences in iNOS gene expression and plasma nitrite/nitrate levels were compared across disease stage using linear and logistic regression analysis. Compared to normal controls, women diagnosed with HSIL or invasive cancer had a significantly higher concentration of plasma nitrite/nitrate and a higher median fold-change in iNOS mRNA gene expression. Genotyping of the promoter region showed three different variations: A pentanucleotide repeat (CCTTT) n, -1026T > G (rs2779249) and a novel variant -1153T > A. These variants were associated with increased levels of plasma nitrite/nitrate across all disease stages. The higher expression of iNOS mRNA and plasma nitrite/nitrate among women with pre-cancerous lesions suggests a role for nitric oxide in the natural history of cervical cancer. PMID:26435258

  19. Real-Time Plasma Process Condition Sensing and Abnormal Process Detection

    PubMed Central

    Yang, Ryan; Chen, Rongshun

    2010-01-01

    The plasma process is often used in the fabrication of semiconductor wafers. However, due to the lack of real-time etching control, this may result in some unacceptable process performances and thus leads to significant waste and lower wafer yield. In order to maximize the product wafer yield, a timely and accurately process fault or abnormal detection in a plasma reactor is needed. Optical emission spectroscopy (OES) is one of the most frequently used metrologies in in-situ process monitoring. Even though OES has the advantage of non-invasiveness, it is required to provide a huge amount of information. As a result, the data analysis of OES becomes a big challenge. To accomplish real-time detection, this work employed the sigma matching method technique, which is the time series of OES full spectrum intensity. First, the response model of a healthy plasma spectrum was developed. Then, we defined a matching rate as an indictor for comparing the difference between the tested wafers response and the health sigma model. The experimental results showed that this proposal method can detect process faults in real-time, even in plasma etching tools. PMID:22219683

  20. Abnormalities of plasma cytokines and spleen in senile APP/PS1/Tau transgenic mouse model

    PubMed Central

    Yang, Seung-Hoon; Kim, Jiyoon; Lee, Michael Jisoo; Kim, YoungSoo

    2015-01-01

    The blood-based diagnosis has a potential to provide an alternative approach for easy diagnosis of Alzheimer’s disease (AD) with less invasiveness and low-cost. However, present blood-based AD diagnosis mainly focuses on measuring the plasma Aβ level because no other biomarkers are found to possess evident transport mechanisms to pass the blood-brain barrier. In order to avoid diagnosing non-demented individuals with Aβ abnormality, finding additional biomarkers to supplement plasma Aβ is essential. In this study, we introduce potential neurodegenerative biomarkers for blood-based diagnosis. We observed severe splenomegaly and structural destruction in the spleen with significantly decreased B lymphocytes in senile APPswe, PS1M146V and TauP301L transgenic mice. We also found that inflammatory cytokines associated with splenic dysfunction were altered in the plasma of these mice. These findings suggest potential involvement of the splenic dysfunction in AD and the importance of biomarker level alterations in the plasma as putative diagnostic targets for AD. PMID:26503550

  1. Relationship between paravascular abnormalities and foveoschisis in highly myopic patients

    PubMed Central

    Kamal-Salah, R; Morillo-Sanchez, M J; Rius-Diaz, F; Garcia-Campos, J M

    2015-01-01

    Purpose To describe the prevalence of paravascular abnormalities in highly myopic patients and its relationship with myopic foveoschisis (MF). Methods Cross-sectional study of 250 highly myopic eyes. All of the patients underwent a complete ophthalmologic examination that included optical coherence tomography . Results Optical coherence tomography images showed 170 eyes (68%) with paravascular microfolds (PM), 121 eyes (48.4%) presented paravascular retinal cysts (PC), and 35 eyes (14%) with paravascular lamellar holes . All the eyes with PCs had PMs. Out of the 250 eyes, 48 (19.2%) had paravascular retinoschisis (PR). All the eyes (100%) with PR had paravascular cysts and PMs. Sixteen eyes (6.4%) had foveoschis. The spherical equivalent (P<0.00), PR (P=0.01), and the presence of tractional structures (P<0.00) were associated with increased risk for foveoschsis in the multivariate study. Conclusions PMs were the lesions most often observed in the paravascular area in highly myopic eyes. MF would be a result of the action of different forces (intra- and extra-ocular forces), specially tractional structures, on precursor lesions (paravascular cyst and paravascular restinoschisis). Further studies are needed to confirm these results. PMID:25359287

  2. Nicotine in Combination With a High-Fat Diet Causes Intramyocellular Mitochondrial Abnormalities in Male Mice

    PubMed Central

    Sinha-Hikim, Indrani; Friedman, Theodore C.; Shin, Chang-Sung; Lee, Desean; Ivey, Rasheed

    2014-01-01

    Smoking is a major risk factor for diabetes, cardiovascular disease, and nonalcoholic fatty liver disease. The health risk associated with smoking can be exaggerated by obesity. We hypothesize that nicotine when combined with a high-fat diet (HFD) can also cause ectopic lipid accumulation in skeletal muscle, similar to recently observed hepatic steatosis. Adult C57BL6 male mice were fed a normal chow diet or HFD and received twice-daily ip injections of nicotine (0.75 mg/kg body weight) or saline for 10 weeks. Transmission electron microscopy of the gastrocnemius muscle revealed substantial intramyocellular lipid accumulation in close association with intramyofibrillar mitochondria along with intramyofibrillar mitochondrial swelling and vacuolization in nicotine-treated mice on an HFD compared with mice on an HFD treated with saline. These abnormalities were reversed by acipimox, an inhibitor of lipolysis. Mechanistically, the detrimental effect of nicotine plus HFD on skeletal muscle was associated with significantly increased oxidative stress, plasma free fatty acid, and muscle triglyceride levels coupled with inactivation of AMP-activated protein kinase and activation of its downstream target, acetyl-coenzyme A-carboxylase. We conclude that 1) greater oxidative stress together with inactivation of AMP-activated protein kinase mediates the effect of nicotine on skeletal muscle abnormalities in diet-induced obesity and 2) adipose tissue lipolysis is an important contributor of muscle steatosis and mitochondrial abnormalities. PMID:24424058

  3. Plasma TGF-β1 Levels Are Elevated in Down Syndrome Infants with Transient Abnormal Myelopoiesis.

    PubMed

    Maeda, Hajime; Go, Hayato; Imamura, Takashi; Sato, Maki; Momoi, Nobuo; Hosoya, Mitsuaki

    2016-01-01

    Infants with Down syndrome (DS) are at risk of developing a transient myeloproliferative disorder during the neonatal period, known as transient abnormal myelopoiesis (TAM). It is characterized by clonal myeloproliferation and is typically self-limiting. However, TAM can be a life-threatening disorder, when complicated by liver fibrosis. Here, we evaluated cytokine profiles in two male DS infants having TAM with or without liver dysfunction. The first patient, Patient 1, had hyperleukocytosis with cholestatic liver dysfunction, coagulopathy, and increased counts of blasts and was treated with exchange transfusion (ExT) due to the serious general condition. In Patient 1, serum interleukin (IL)-8 and plasma transforming growth factor (TGF)-β1 levels were markedly elevated before ExT (1,518.2 pg/mL and 17,635 pg/mL, respectively). After ExT, serum IL-8 and plasma TGF-β1 levels decreased to 40.7 pg/mL and 6,847 pg/mL, respectively. However, Patient 1 died on day 56 due to cholestatic liver dysfunction; namely, this patient represents fatal TAM. The second patient, Patient 2, had hyperleukocytosis with increased counts of blasts without liver dysfunction and was treated with cytarabine. In Patient 2, plasma TGF-β1 levels, but not plasma IL-8, were elevated (9,068 pg/mL and 28 pg/mL, respectively). Patient 2 was discharged on day 47. In summary, plasma TGF-β1 levels were elevated in the two DS infants with TAM, regardless of the presence or absence of hepatic fibrosis. Importantly, fatal TAM is assoicated with the elevated serum level of IL-8. We thus propose that IL-8 may be involved in the pathogenesis of liver fibrosis. PMID:27546516

  4. Abnormal Elastic and Vibrational Behaviors of Magnetite at High Pressures

    NASA Astrophysics Data System (ADS)

    Lin, Jung-Fu; Wu, Junjie; Zhu, Jie; Mao, Zhu; Said, Ayman H.; Leu, Bogdan M.; Cheng, Jinguang; Uwatoko, Yoshiya; Jin, Changqing; Zhou, Jianshi

    2014-09-01

    Magnetite exhibits unique electronic, magnetic, and structural properties in extreme conditions that are of great research interest. Previous studies have suggested a number of transitional models, although the nature of magnetite at high pressure remains elusive. We have studied a highly stoichiometric magnetite using inelastic X-ray scattering, X-ray diffraction and emission, and Raman spectroscopies in diamond anvil cells up to ~20 GPa, while complementary electrical conductivity measurements were conducted in a cubic anvil cell up to 8.5 GPa. We have observed an elastic softening in the diagonal elastic constants (C11 and C44) and a hardening in the off-diagonal constant (C12) at ~8 GPa where significant elastic anisotropies in longitudinal and transverse acoustic waves occur, especially along the [110] direction. An additional vibrational Raman band between the A1g and T2g modes was also detected at the transition pressure. These abnormal elastic and vibrational behaviors of magnetite are attributed to the occurrence of the octahedrally-coordinated Fe2+-Fe3+-Fe2+ ions charge-ordering along the [110] direction in the inverse spinel structure. We propose a new phase diagram of magnetite in which the temperature for the metal-insulator and distorted structural transitions decreases with increasing pressure while the charge-ordering transition occurs at ~8 GPa and room temperature.

  5. Abnormal Elastic and Vibrational Behaviors of Magnetite at High Pressures

    PubMed Central

    Lin, Jung-Fu; Wu, Junjie; Zhu, Jie; Mao, Zhu; Said, Ayman H.; Leu, Bogdan M.; Cheng, Jinguang; Uwatoko, Yoshiya; Jin, Changqing; Zhou, Jianshi

    2014-01-01

    Magnetite exhibits unique electronic, magnetic, and structural properties in extreme conditions that are of great research interest. Previous studies have suggested a number of transitional models, although the nature of magnetite at high pressure remains elusive. We have studied a highly stoichiometric magnetite using inelastic X-ray scattering, X-ray diffraction and emission, and Raman spectroscopies in diamond anvil cells up to ~20 GPa, while complementary electrical conductivity measurements were conducted in a cubic anvil cell up to 8.5 GPa. We have observed an elastic softening in the diagonal elastic constants (C11 and C44) and a hardening in the off-diagonal constant (C12) at ~8 GPa where significant elastic anisotropies in longitudinal and transverse acoustic waves occur, especially along the [110] direction. An additional vibrational Raman band between the A1g and T2g modes was also detected at the transition pressure. These abnormal elastic and vibrational behaviors of magnetite are attributed to the occurrence of the octahedrally-coordinated Fe2+-Fe3+-Fe2+ ions charge-ordering along the [110] direction in the inverse spinel structure. We propose a new phase diagram of magnetite in which the temperature for the metal-insulator and distorted structural transitions decreases with increasing pressure while the charge-ordering transition occurs at ~8 GPa and room temperature. PMID:25186916

  6. Abnormal elastic and vibrational behaviors of magnetite at high pressures.

    PubMed

    Lin, Jung-Fu; Wu, Junjie; Zhu, Jie; Mao, Zhu; Said, Ayman H; Leu, Bogdan M; Cheng, Jinguang; Uwatoko, Yoshiya; Jin, Changqing; Zhou, Jianshi

    2014-01-01

    Magnetite exhibits unique electronic, magnetic, and structural properties in extreme conditions that are of great research interest. Previous studies have suggested a number of transitional models, although the nature of magnetite at high pressure remains elusive. We have studied a highly stoichiometric magnetite using inelastic X-ray scattering, X-ray diffraction and emission, and Raman spectroscopies in diamond anvil cells up to ~20 GPa, while complementary electrical conductivity measurements were conducted in a cubic anvil cell up to 8.5 GPa. We have observed an elastic softening in the diagonal elastic constants (C11 and C44) and a hardening in the off-diagonal constant (C12) at ~8 GPa where significant elastic anisotropies in longitudinal and transverse acoustic waves occur, especially along the [110] direction. An additional vibrational Raman band between the A1g and T2g modes was also detected at the transition pressure. These abnormal elastic and vibrational behaviors of magnetite are attributed to the occurrence of the octahedrally-coordinated Fe(2+)-Fe(3+)-Fe(2+) ions charge-ordering along the [110] direction in the inverse spinel structure. We propose a new phase diagram of magnetite in which the temperature for the metal-insulator and distorted structural transitions decreases with increasing pressure while the charge-ordering transition occurs at ~8 GPa and room temperature. PMID:25186916

  7. Abnormal Adrenal Responsiveness and Angiotensin II Dependency in High Renin Essential Hypertension

    PubMed Central

    Dluhy, Robert G.; Bavli, Sam Z.; Leung, Frank K.; Solomon, Harold S.; Moore, Thomas J.; Hollenberg, Norman K.; Williams, Gordon H.

    1979-01-01

    Adrenal responsiveness to angiotensin II (AII) and the diastolic blood pressure responses to saralasin were studied in 19 patients with high renin essential hypertension (HREH) on a 10-meq Na+/100 meq K+ diet. The increment in plasma renin activity (PRA) between supine and upright positions was used as an estimate of the acute stimulation of the adrenal gland by endogenous AII; the normal increment in plasma aldosterone divided by the increment in PRA was >3.8. 7 of 19 had abnormal upright posture responses with significantly greater mean PRA increments (24±6 ng/ml per h) and significantly smaller plasma aldosterone increments 47 ± 16 ng/dl) (P < 0.036) compared to the increments observed in HREH patients with normal adrenal responsiveness (PRA = 15 ± 1 ng/ml per h; plasma aldosterone = 87 ± 17 ng/dl). When AII was infused at doses of 0.1-3 ng/kg per min, only patients with normal posture responses had normal plasma aldosterone increments; plasma aldosterone levels failed to significantly increase even at the highest infusion rate in the patients with the abnormal upright posture responses. The AII competitive inhibitor, saralasin (0.3-30 μg/kg per min) was then infused to study the occurrence of angiotensinogenic hypertension in both HREH subgroups. The mean decline in diastolic blood pressure to saralasin in the subnormal adrenal responsive patients (−15 ± 3 mm Hg) was significantly greater than in the normal adrenal responsive group (−3 ± 2 mm Hg) (P < 0.02). It is concluded that patients with HREH are not a homogeneous population; approximately one-third have AII-dependent hypertension. In these patients, the mechanism responsible for the elevated renin and blood pressure could be a compensatory increase secondary to decreased adrenal responsiveness to AII. In the remainder, the high PRA levels have little, if any, causal role in the pathogenesis of the hypertension but could reflect a marker of other pathophysiologic processes. PMID:500810

  8. Abnormally high expression of proteasomes in human leukemic cells.

    PubMed Central

    Kumatori, A; Tanaka, K; Inamura, N; Sone, S; Ogura, T; Matsumoto, T; Tachikawa, T; Shin, S; Ichihara, A

    1990-01-01

    Proteasomes are eukaryotic ring-shaped or cylindrical particles with multicatalytic protease activities. To clarify the involvement of proteasomes in tumorigenesis of human blood cells, we compared their expression in human hematopoietic malignant tumor cells with that in normal peripheral blood mononuclear cells. Immunohistochemical staining showed considerably increased concentrations of proteasomes in leukemic cells from the bone marrow of patients with various types of leukemia and the predominant localization of these proteasomes in the nuclei. Moreover, enzyme immunoassay and Northern blot analysis indicated that the concentrations of proteasomes and their mRNA levels were consistently much higher in a variety of malignant human hematopoietic cell lines than in resting peripheral lymphocytes and monocytes from healthy adults. Proteasome expression was also greatly increased in normal blood mononuclear cells during blastogenic transformation induced by phytohemagglutinin; their expression increased in parallel with induction of DNA synthesis and returned to the basal level with progress of the cell cycle. Thus, abnormally high expression of proteasomes may play an important role in transformation and proliferation of blood cells and in specific functions of hematopoietic tumor cells. Images PMID:2205851

  9. CONFINEMENT OF HIGH TEMPERATURE PLASMA

    DOEpatents

    Koenig, H.R.

    1963-05-01

    The confinement of a high temperature plasma in a stellarator in which the magnetic confinement has tended to shift the plasma from the center of the curved, U-shaped end loops is described. Magnetic means are provided for counteracting this tendency of the plasma to be shifted away from the center of the end loops, and in one embodiment this magnetic means is a longitudinally extending magnetic field such as is provided by two sets of parallel conductors bent to follow the U-shaped curvature of the end loops and energized oppositely on the inside and outside of this curvature. (AEC)

  10. High prevalence of thyroid ultrasonographic abnormalities in primary aldosteronism.

    PubMed

    Armanini, Decio; Nacamulli, Davide; Scaroni, Carla; Lumachi, Franco; Selice, Riccardo; Fiore, Cristina; Favia, Gennaro; Mantero, Franco

    2003-11-01

    The study was performed to evaluate the prevalence of thyroid abnormalities detected by ultrasonography and, in particular, of multinodular nontoxic goiter in primary aldosteronism. We analyzed 80 consecutive of patients with primary hyperaldosteronism (40 with unilateral adenoma and 40 with idiopathic hyperaldosteronism) and 80 normotensive healthy controls, comparable for age, sex, iodine intake, and geographical area. Blood pressure, thyroid palpation, thyroid function, and ultrasonography were evaluated. The prevalence of ultrasonographic thyroid abnormalities was 60% in primary aldosteronism and 27% in controls (p < 0.0001). There was a statistically significant difference in prevalence of these abnormalities in unilateral adenoma and idiopathic hyperaldosteronism with respect to controls (p < 0.05 and p < 0.0001, respectively). The prevalence of multinodular nontoxic goiter in idiopathic hyperaldosteronism was higher than in controls (p < 0.001) and, in particular, in female patients. From these data it seems to be worth considering the existence of primary hyperaldosteronism in patients with multinodular goiter and hypertension. PMID:14665720

  11. Increased Fetal Plasma Erythropoietin in Monochorionic Twin Pregnancies With Selective Intrauterine Growth Restriction and Abnormal Umbilical Artery Doppler.

    PubMed

    Chang, Yao-Lung; Chao, An-Shine; Peng, Hsiu-Huei; Chang, Shuenn-Dyh; Su, Sheng-Yuan; Chen, Kuan-Ju; Cheng, Po-Jen; Wang, Tzu-Hao

    2016-08-01

    Hypoxia is the primary stimulus for the production of erythropoietin (EPO) in both fetal and adult life. Here, we investigated fetal plasma EPO concentrations in monochorionic (MC) twin pregnancies with selective intrauterine growth restriction (sIUGR) and abnormal umbilical artery (UA) Doppler. We diagnosed sIUGR in presence of (1) birth-weight discordance >20% and (2) either twin with a birth weight <10th percentile. An abnormal UA Doppler was defined as a persistent absent-reverse end diastolic flow (AREDF). The intertwin EPO ratio was calculated as the plasma EPO level of the smaller (or small-for-gestational-age) twin divided by the EPO concentration of the larger (or appropriate-for-gestational-age (AGA)) twin. Thirty-two MC twin pairs were included. Of these, 17 pairs were normal twins (Group 1), seven pairs were twins with sIUGR without UA Doppler abnormalities (Group 2), and eight pairs were twins with sIUGR and UA Doppler abnormalities (Group 3). The highest EPO ratio was identified in Group 3 (p < .001) but no significant differences were observed between Groups 1 and 2. Fetal hemoglobin levels did not differ significantly in the three groups, and fetal EPO concentration did not correlate with gestational age at birth. We conclude that fetal plasma EPO concentrations are selectively increased in MC twin pregnancies with sIUGR and abnormal UA Doppler, possibly as a result of uncompensated hypoxia. PMID:27161360

  12. 14 CFR 91.144 - Temporary restriction on flight operations during abnormally high barometric pressure conditions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... during abnormally high barometric pressure conditions. 91.144 Section 91.144 Aeronautics and Space... flight operations during abnormally high barometric pressure conditions. (a) Special flight restrictions. When any information indicates that barometric pressure on the route of flight currently exceeds...

  13. 14 CFR 91.144 - Temporary restriction on flight operations during abnormally high barometric pressure conditions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... during abnormally high barometric pressure conditions. 91.144 Section 91.144 Aeronautics and Space... flight operations during abnormally high barometric pressure conditions. (a) Special flight restrictions. When any information indicates that barometric pressure on the route of flight currently exceeds...

  14. 14 CFR 91.144 - Temporary restriction on flight operations during abnormally high barometric pressure conditions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... during abnormally high barometric pressure conditions. 91.144 Section 91.144 Aeronautics and Space... flight operations during abnormally high barometric pressure conditions. (a) Special flight restrictions. When any information indicates that barometric pressure on the route of flight currently exceeds...

  15. 14 CFR 91.144 - Temporary restriction on flight operations during abnormally high barometric pressure conditions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... during abnormally high barometric pressure conditions. 91.144 Section 91.144 Aeronautics and Space... flight operations during abnormally high barometric pressure conditions. (a) Special flight restrictions. When any information indicates that barometric pressure on the route of flight currently exceeds...

  16. 14 CFR 91.144 - Temporary restriction on flight operations during abnormally high barometric pressure conditions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... during abnormally high barometric pressure conditions. 91.144 Section 91.144 Aeronautics and Space... flight operations during abnormally high barometric pressure conditions. (a) Special flight restrictions. When any information indicates that barometric pressure on the route of flight currently exceeds...

  17. The High Fidelity Plasma Speaker

    NASA Astrophysics Data System (ADS)

    McGall, James

    2014-10-01

    A plasma speaker is a device that uses ionized gas as the driving source of sound production, rather than the traditional magnetic coil and membrane setup found on a standard speaker. Similar to how lightning produces sound, or even a small static shock, a plasma speaker uses a modulating electric arc between two electrodes to produce sound. An electric circuit is built that allows the variance of the high voltage electric potential to be controlled by a 3.5 mm standard audio headphone jack, allowing sound energy to be transferred from the plasma to the air by means of pulse width modulation. For my summer project I have built two different models of plasma speakers and am working on a third. The speaker benefits from having a nearly massless driver, and I hypothesize that it should show a response rate faster than that of a traditional speaker and a decreased impulse response while having the drawbacks of inefficiency and a low maximum decibel output. The speakers are currently being optimized with magnetic stabilization of the plasma and will be tested soon for impulse response, frequency generation, efficiency, and audio coloration. Bridges for SUCCESS Grant at Salisbury University under Ph.D. Matthew Bailey.

  18. Isolation and Characterization of an Abnormal High Density Lipoprotein in Tangier Disease

    PubMed Central

    Assmann, Gerd; Herbert, Peter N.; Fredrickson, Donald S.; Forte, Trudy

    1977-01-01

    The nature of the high density lipoproteins has been investigated in five patients homozygous for Tangier disease (familial high density lipoprotein deficiency). It has been established that Tangier high density lipoproteins, as isolated by ultracentrifugation, are morphologically heterogenous and contain several proteins (Apo B, albumin, and Apo A-II). An abnormal lipoprotein has been isolated from the d = 1.063-1.21 g/ml ultracentrifugal fraction by agarose-column chromatography which contains apoprotein A-II as the sole protein constituent. In negative-stain electron microscopy, these lipoproteins appeared as spherical particles 55-75 Å in diameter. By a variety of criteria (immunochemical, polyacrylamide electrophoresis, amino acid composition, and fluorescence measurements), apoprotein A-I the major apoprotein of normal high density lipoproteins and the C apoproteins were absent from this lipoprotein. As demonstrated by 125I very low density lipoprotein incubation experiments with Tangier plasma, C apoproteins did not associate with lipoproteins of d = 1.063-1.21 g/ml. Tangier apoprotein A-II, isolated to homogeneity by delipidation of the apoprotein A-II-containing lipoprotein or Sephadex G-200 guanidine-HCl chromatography of the d = 1.063-1.21 g/ml fraction, was indistinguishable from control apoprotein A-II with respect to amino acid composition and migration of tryptic peptides in urea-polyacrylamide electrophoresis. The ability of Tangier apoprotein A-II to bind phospholipid was demonstrated by in vitro reconstitution experiments and morphological and chemical analysis of lipid-protein complexes. It is concluded that normal high density lipoproteins, as defined by polypeptide composition and morphological appearance, are absent from Tangier plasma and that as a consequence, the impairment of C apoprotein metabolism contributes to the hypertriglyceridemia and fasting chylomicronemia observed in these patients. Images PMID:194920

  19. High beta plasma operation in a toroidal plasma producing device

    DOEpatents

    Clarke, John F.

    1978-01-01

    A high beta plasma is produced in a plasma producing device of toroidal configuration by ohmic heating and auxiliary heating. The plasma pressure is continuously monitored and used in a control system to program the current in the poloidal field windings. Throughout the heating process, magnetic flux is conserved inside the plasma and the distortion of the flux surfaces drives a current in the plasma. As a consequence, the total current increases and the poloidal field windings are driven with an equal and opposing increasing current. The spatial distribution of the current in the poloidal field windings is determined by the plasma pressure. Plasma equilibrium is maintained thereby, and high temperature, high beta operation results.

  20. High-power radiating plasma

    NASA Technical Reports Server (NTRS)

    Rozanov, V. B.; Rukhadze, A. A.

    1984-01-01

    The physical principles underlying the use of radiating plasmas for the optical pumping of lasers are described. Particular consideration is given to the properties of radiating plasmas; radiation selectivity; the dynamics, equilibrium, and stability of radiating plasmas; the radiative Reynolds number; and experimental results on radiating discharges.

  1. Nerve conduction abnormalities in untreated maturity-onset diabetes: relation to levels of fasting plasma glucose and glycosylated hemoglobin.

    PubMed

    Graf, R J; Halter, J B; Halar, E; Porte, D

    1979-03-01

    The role of metabolic abnormalities in the development of diabetic neuropathy is controversial. To investigate the influence of hyperglycemia on nerve conduction, we studied 20 untreated maturity-onset diabetic patients and 23 normal control subjects of similar age. Nerve conduction velocity of motor (median, peroneal, and tibial) and sensory (median and sural) nerves in diabetic patients was significantly slowed and H-reflex latency time prolonged. Levels of fasting plasma glucose in diabetic subjects were correlated with slowed motor conduction velocity of the median, peroneal, and tibial nerves but not with sensory nerve conduction velocities. Levels of glycosylated hemoglobin, an index of long-term glycemia, were correlated with slowing of peroneal motor conduction velocity in diabetic patients. These associations could not be explained by patient age or duration of diabetes. These findings suggest that the degree of hyperglycemia of untreated maturity-onset diabetes contributes to the motor nerve conduction abnormalities in this disease. PMID:426398

  2. Method of curved surface abnormal holes vision measurement based on high precision turntable

    NASA Astrophysics Data System (ADS)

    Lyu, Laipeng; Bi, Chao; Fang, Jianguo; Zhu, Yong; Wang, Liping

    2015-10-01

    For solving the difficult problem that there is no effective way to measure abnormal holes located at blade erection loop of aero-engine case, an image measurement system based on high precision air-bearing turntable is established in this paper. The issue that monocular vision can't measure curved surface has overcome by using high precision turntable to make sure high positioning accuracy of the surface abnormal holes and high-resolution microscope lens which is used to image local tiny features. Besides, an algorithm of determining the boundary points of a trailing edge on the contour of abnormal hole is proposed to achieve a rapid fitting and accuracy. After experiments and analysis, results show that the system can be used to measure local tiny features on curved surfaces validly and efficiently.

  3. Sasa quelpaertensis leaf extract improves high fat diet-induced lipid abnormalities and regulation of lipid metabolism genes in rats.

    PubMed

    Kim, Jina; Kim, Yoo-Sun; Lee, Hyun Ah; Lim, Ji Ye; Kim, Mina; Kwon, Oran; Ko, Hee-Chul; Kim, Se-Jae; Shin, Jae-Ho; Kim, Yuri

    2014-05-01

    Sasa quelpaertensis is a bamboo leaf that is only grown on Jeju Island in South Korea. It is used as a bamboo tea that is consumed for therapeutic purposes, particularly for its anti-diabetic, diuretic, and anti-inflammatory effects. This study investigated the effect of S. quelpaertensis leaf extract (SQE) on high fat-induced lipid abnormalities and regulation of lipid metabolism-related gene expressions in rats. SQE supplementation significantly decreased the levels of plasma triglycerides, total cholesterol, and low-density lipoprotein cholesterol as well as the atherogenic index. SQE restored levels of plasma high-density lipoprotein cholesterol, which were lowered by a high fat diet. Plasma and cardiac resistin levels were also significantly decreased by SQE supplementation. In adipose tissue, mRNA levels of CAAT/enhancer-binding protein β (C/EBPβ) were suppressed in the SQE group. SQE supplementation decreased the accumulation of lipid droplets, inflammatory cell infiltrations, levels of triglycerides, and total lipids in the liver and effectively down-regulated expression of sterol regulatory element binding protein-1 (SREBP-1), fatty acid synthetase (FAS), and uncoupling protein 2 (UCP-2). These results suggest that SQE may be a potential treatment for high fat-related disorders by improving lipid profiles and modulating lipid metabolism. PMID:24738745

  4. Merging of high speed argon plasma jets

    SciTech Connect

    Case, A.; Messer, S.; Brockington, S.; Wu, L.; Witherspoon, F. D.; Elton, R.

    2013-01-15

    Formation of an imploding plasma liner for the plasma liner experiment (PLX) requires individual plasma jets to merge into a quasi-spherical shell of plasma converging on the origin. Understanding dynamics of the merging process requires knowledge of the plasma phenomena involved. We present results from the study of the merging of three plasma jets in three dimensional geometry. The experiments were performed using HyperV Technologies Corp. 1 cm Minirailguns with a preionized argon plasma armature. The vacuum chamber partially reproduces the port geometry of the PLX chamber. Diagnostics include fast imaging, spectroscopy, interferometry, fast pressure probes, B-dot probes, and high speed spatially resolved photodiodes, permitting measurements of plasma density, temperature, velocity, stagnation pressure, magnetic field, and density gradients. These experimental results are compared with simulation results from the LSP 3D hybrid PIC code.

  5. iTRAQ-based proteomic analysis of plasma reveals abnormalities in lipid metabolism proteins in chronic kidney disease-related atherosclerosis.

    PubMed

    Luczak, Magdalena; Formanowicz, Dorota; Marczak, Łukasz; Suszyńska-Zajczyk, Joanna; Pawliczak, Elżbieta; Wanic-Kossowska, Maria; Stobiecki, Maciej

    2016-01-01

    Patients with chronic kidney disease (CKD) have a considerably higher risk of death due to cardiovascular causes. Using an iTRAQ MS/MS approach, we investigated the alterations in plasma protein accumulation in patients with CKD and classical cardiovascular disease (CVD) without CKD. The proteomic analysis led to the identification of 130 differentially expressed proteins among CVD and CKD patients and healthy volunteers. Bioinformatics analysis revealed that 29 differentially expressed proteins were involved in lipid metabolism and atherosclerosis, 20 of which were apolipoproteins and constituents of high-density lipoprotein (HDL) and low-density lipoprotein (LDL). Although dyslipidemia is common in CKD patients, we found that significant changes in apolipoproteins were not strictly associated with changes in plasma lipid levels. A lack of correlation between apoB and LDL concentration and an inverse relationship of some proteins with the HDL level were revealed. An increased level of apolipoprotein AIV, adiponectin, or apolipoprotein C, despite their anti-atherogenic properties, was not associated with a decrease in cardiovascular event risk in CKD patients. The presence of the distinctive pattern of apolipoproteins demonstrated in this study may suggest that lipid abnormalities in CKD are characterized by more qualitative abnormalities and may be related to HDL function rather than HDL deficiency. PMID:27600335

  6. iTRAQ-based proteomic analysis of plasma reveals abnormalities in lipid metabolism proteins in chronic kidney disease-related atherosclerosis

    PubMed Central

    Luczak, Magdalena; Formanowicz, Dorota; Marczak, Łukasz; Suszyńska-Zajczyk, Joanna; Pawliczak, Elżbieta; Wanic-Kossowska, Maria; Stobiecki, Maciej

    2016-01-01

    Patients with chronic kidney disease (CKD) have a considerably higher risk of death due to cardiovascular causes. Using an iTRAQ MS/MS approach, we investigated the alterations in plasma protein accumulation in patients with CKD and classical cardiovascular disease (CVD) without CKD. The proteomic analysis led to the identification of 130 differentially expressed proteins among CVD and CKD patients and healthy volunteers. Bioinformatics analysis revealed that 29 differentially expressed proteins were involved in lipid metabolism and atherosclerosis, 20 of which were apolipoproteins and constituents of high-density lipoprotein (HDL) and low-density lipoprotein (LDL). Although dyslipidemia is common in CKD patients, we found that significant changes in apolipoproteins were not strictly associated with changes in plasma lipid levels. A lack of correlation between apoB and LDL concentration and an inverse relationship of some proteins with the HDL level were revealed. An increased level of apolipoprotein AIV, adiponectin, or apolipoprotein C, despite their anti-atherogenic properties, was not associated with a decrease in cardiovascular event risk in CKD patients. The presence of the distinctive pattern of apolipoproteins demonstrated in this study may suggest that lipid abnormalities in CKD are characterized by more qualitative abnormalities and may be related to HDL function rather than HDL deficiency. PMID:27600335

  7. Time Orientation in the Positive and Negative Free Phantasies of Mildly Abnormal Versus Normal High School Males

    ERIC Educational Resources Information Center

    Rychlak, Joseph F.

    1973-01-01

    This study contrasts a group of mildly'' abnormal high school males with matched normals in a two-session free phantasy procedure. Mildly abnormal boys phantasized more negative contents than normal boys. Normal boys projected more positive phantasies into the future than mildly abnormal boys. A logical learning theory'' embracing the…

  8. High Energy Plasma Space Propulsion

    NASA Technical Reports Server (NTRS)

    Wu, S. T.

    2000-01-01

    In order to meet NASA's challenge on advanced concept activity in the propulsion area, we initiated a new program entitled "High Energy Plasma Space Propulsion Studies" within the current cooperative agreement in 1998. The goals of this work are to gain further understanding of the engine of the AIMStar spacecraft, a concept which was developed at Penn State University, and to develop a prototype concept for the engine. The AIMStar engine concept was developed at Penn State University several years ago as a hybrid between antimatter and fusion technologies. Because of limited amounts of antimatter available, and concurrently the demonstrated ability for antiprotons to efficiently ignite nuclear fusion reactions, it was felt that this was a very good match. Investigations have been made concerning the performance of the reaction trap. This is a small Penning-like electromagnetic trap, which is used to simultaneously confine antiprotons and fusion fuels. Small DHe3 or DT droplets, containing a few percent molar of a fissile material, are injected into the trap, filled with antiprotons. We have found that it is important to separate the antiprotons into two adjacent wells, to inject he droplet between them and to simultaneously bring the antiprotons to the center of the trap, surrounding the droplet. Our previous concept had the droplet falling onto one cloud of antiprotons. This proved to be inefficient, as the droplet tended to evaporate away from the cloud as it interacted on its surface.

  9. An Algorithm for the Segmentation of Highly Abnormal Hearts Using a Generic Statistical Shape Model.

    PubMed

    Alba, Xenia; Pereanez, Marco; Hoogendoorn, Corne; Swift, Andrew J; Wild, Jim M; Frangi, Alejandro F; Lekadir, Karim

    2016-03-01

    Statistical shape models (SSMs) have been widely employed in cardiac image segmentation. However, in conditions that induce severe shape abnormality and remodeling, such as in the case of pulmonary hypertension (PH) or hypertrophic cardiomyopathy (HCM), a single SSM is rarely capable of capturing the anatomical variability in the extremes of the distribution. This work presents a new algorithm for the segmentation of severely abnormal hearts. The algorithm is highly flexible, as it does not require a priori knowledge of the involved pathology or any specific parameter tuning to be applied to the cardiac image under analysis. The fundamental idea is to approximate the gross effect of the abnormality with a virtual remodeling transformation between the patient-specific geometry and the average shape of the reference model (e.g., average normal morphology). To define this mapping, a set of landmark points are automatically identified during boundary point search, by estimating the reliability of the candidate points. With the obtained transformation, the feature points extracted from the patient image volume are then projected onto the space of the reference SSM, where the model is used to effectively constrain and guide the segmentation process. The extracted shape in the reference space is finally propagated back to the original image of the abnormal heart to obtain the final segmentation. Detailed validation with patients diagnosed with PH and HCM shows the robustness and flexibility of the technique for the segmentation of highly abnormal hearts of different pathologies. PMID:26552082

  10. High voltage space plasma interactions

    NASA Astrophysics Data System (ADS)

    McCoy, J. E.

    1980-07-01

    Two primary problems resulted from plasma interactions; one of concern to operations in geosynchronous orbit (GEO), the other in low orbits (LEO). The two problems are not the same. Spacecraft charging has become widely recognized as a problem, particularly for communications satellites operating in GEO. The very thin thermal plasmas at GEO are insufficient to bleed off voltage buildups due to higher energy charged particle radiation collected on outer surfaces. Resulting differential charging/discharging causes electrical transients, spurious command signals and possible direct overload damage. An extensive NASA/Air Force program has been underway for several years to address this problem. At lower altitudes, the denser plasmas of the plasmasphere/ionosphere provide sufficient thermal current to limit such charging to a few volts or less. Unfortunately, these thermal plasma currents which solve the GEO spacecraft charging problem can become large enough to cause just the opposite problem in LEO.

  11. Abnormal Pap Smear and Diagnosis of High-Grade Vaginal Intraepithelial Neoplasia: A Retrospective Cohort Study.

    PubMed

    Sopracordevole, Francesco; Mancioli, Francesca; Clemente, Nicolò; De Piero, Giovanni; Buttignol, Monica; Giorda, Giorgio; Ciavattini, Andrea

    2015-10-01

    The aim of this study was to analyze the correlation between the first diagnosis of high-grade Vaginal Intraepithelial Neoplasia (HG-VaIN: VaIN 2-VaIN 3) and the cytological abnormalities on the referral pap smear.All the women with histological diagnosis of HG-VaIN consecutively referred to the Gynecological Oncology Unit of the Aviano National Cancer Institute (Aviano, Italy) from January 1991 to April 2014 and with a pap smear performed in the 3 months before the diagnosis were considered, and an observational cohort study was performed.A total of 87 women with diagnosis of HG-VaIN were identified. Major cytological abnormalities (HSIL and ASC-H) on the referral pap smear were significantly more frequent than lesser abnormalities (ASC-US and LSIL) in postmenopausal women (64.9% vs 36.7%, P = 0.02) and in women with a previous diagnosis of HPV-related cervical preinvasive or invasive lesions (70.5% vs 39.5%, P = 0.01). Diagnosis of VaIN 3 was preceded by major cytological abnormalities in most of the cases (72.7% vs 27.3%, P < 0.001).The diagnosis of HG-VaIN can be preceded by different abnormalities on referral pap smear. Major abnormalities are usually reported in postmenopausal women and in women with previous cervical HPV-related disease. However, ASC-US or LSIL do not exclude HG-VaIN, especially VaIN2. An accurate examination of the whole vaginal walls (or vaginal vault) must be performed in all the women who underwent colposcopy for an abnormal pap smear, and a biopsy of all suspicious areas is mandatory. PMID:26496321

  12. Abnormal Heart Rate Turbulence Predicts Cardiac Mortality in Low, Intermediate and High Risk Older Adults

    PubMed Central

    Stein, Phyllis K.; Barzilay, Joshua I.

    2011-01-01

    Introduction We examined whether heart rate turbulence (HRT) adds to traditional risk factors for cardiac mortality in older adults at low, intermediate and high risk. Methods and Results N=1298, age ≥65 years, with 24-hour Holter recordings were studied. HRT, which quantifies heart rate response to ventricular premature contractions, was categorized as: both turbulence onset (TO) and turbulence slope (TS) normal; TO abnormal; TS abnormal; or both abnormal. Independent risks for cardiac mortality associated with HRT or, for comparison, elevated C-reactive protein (CRP) (>3.0 mg/L), were calculated using Cox regression analysis adjusted for traditional cardiovascular disease risk factors and stratified by the presence of no, isolated subclinical (i.e., intermediate risk) or clinical CVD. Having both TS and TO abnormal compared to both normal was associated with cardiac mortality in the low risk group [HR 7.9, 95% CI 2.8–22.5, (p<0.001)]. In the high and intermediate risk groups, abnormal TS and TO ([HR 2.2, 95% CI 1.5–4.0, p=0.016] and [HR 2.7, 95% CI 1.2–5.9, p=0.012]), respectively, were also significantly associated with cardiac mortality. In contrast, elevated CRP was associated with increased cardiac mortality risk only in low risk individuals [HR 2.5, 95% CI 1.3–5.1, p=0.009]. In the low risk group, the c-statistic was 0.706 for the base model, 0.725 for the base model with CRP, and 0.767 for the base model with HRT. Conclusions Abnormal HRT independently adds to risk stratification of low, intermediate and high risk individuals but appears to add especially to the stratification of those considered at low risk. PMID:21134026

  13. Plasma effects in high frequency radiative transfer

    SciTech Connect

    Alonso, C.T.

    1981-02-08

    This paper is intended as a survey of collective plasma processes which can affect the transfer of high frequency radiation in a hot dense plasma. We are rapidly approaching an era when this subject will become important in the laboratory. For pedagogical reasons we have chosen to examine plasma processes by relating them to a particular reference plasma which will consist of fully ionized carbon at a temperature kT=1 KeV (10/sup 70/K) and an electron density N = 3 x 10/sup 23/cm/sup -3/, (which corresponds to a mass density rho = 1 gm/cm/sup 3/ and an ion density N/sub i/ = 5 x 10/sup 22/ cm/sup -3/). We will consider the transport in such a plasma of photons ranging from 1 eV to 1 KeV in energy. Such photons will probably be frequently used as diagnostic probes of hot dense laboratory plasmas.

  14. Antenna development for high field plasma imaging

    SciTech Connect

    Kong, X.; Domier, C. W.; Luhmann, N. C. Jr.

    2010-10-15

    Electron cyclotron emission imaging (ECEI) and microwave imaging reflectometry (MIR) are two microwave nonperturbing plasma visualization techniques that employ millimeter-wave imaging arrays with lens-coupled planar antennas, yielding time-resolved images of temperature (via ECEI) and electron density (via MIR) fluctuations within high temperature magnetic fusion plasmas. A series of new planar antennas have been developed that extend this technology to frequencies as high as 220 GHz for use on high field plasma devices with toroidal fields in excess of 3 T. Antenna designs are presented together with theoretical calculations, simulations, and experimental measurements.

  15. A High-Efficiency Superhydrophobic Plasma Separator

    PubMed Central

    Liu, Changchun; Liao, Shih-Chuan; Song, Jinzhao; Mauk, Michael G.; Li, Xuanwen; Wu, Gaoxiang; Ge, Dengteng; Greenberg, Robert M.; Yang, Shu; Bau, Haim H.

    2016-01-01

    To meet stringent limit-of-detection specifications for low abundance target molecules, a relatively large volume of plasma is needed for many blood-based clinical diagnostics. Conventional centrifugation methods for plasma separation are not suitable for on-site testing or bedside diagnostics. Here, we report a simple, yet high-efficiency, clamshell-style, superhydrophobic plasma separator that is capable of separating a relatively large volume of plasma from several hundred microliters of whole blood (finger-prick blood volume). The plasma separator consists of a superhydrophobic top cover with a separation membrane and a superhydrophobic bottom substrate. Unlike previously reported membrane-based plasma separators, the separation membrane in our device is positioned at the top of the sandwiched whole blood film to increase the membrane separation capacity and plasma yield. In addition, the device’s superhydrophobic characteristics (i) facilitates the formation of well-defined, contracted, thin blood film with a high contact angle; (ii) minimizes biomolecular adhesion to surfaces; (iii) increases blood clotting time; and (iv) reduces blood cell hemolysis. The device demonstrated a “blood in-plasma out” capability, consistently extracting 65±21.5 μL of plasma from 200 μL of whole blood in less than 10 min without electrical power. The device was used to separate plasma from Schistosoma mansoni genomic DNA-spiked whole blood with a recovery efficiency of > 84.5 ± 25.8 %. The S. mansoni genomic DNA in the separated plasma was successfully tested on our custom-made microfluidic chip by using loop mediated isothermal amplification (LAMP) method. PMID:26732765

  16. A high-efficiency superhydrophobic plasma separator.

    PubMed

    Liu, Changchun; Liao, Shih-Chuan; Song, Jinzhao; Mauk, Michael G; Li, Xuanwen; Wu, Gaoxiang; Ge, Dengteng; Greenberg, Robert M; Yang, Shu; Bau, Haim H

    2016-02-01

    To meet stringent limit-of-detection specifications for low abundance target molecules, a relatively large volume of plasma is needed for many blood-based clinical diagnostics. Conventional centrifugation methods for plasma separation are not suitable for on-site testing or bedside diagnostics. Here, we report a simple, yet high-efficiency, clamshell-style, superhydrophobic plasma separator that is capable of separating a relatively large volume of plasma from several hundred microliters of whole blood (finger-prick blood volume). The plasma separator consists of a superhydrophobic top cover with a separation membrane and a superhydrophobic bottom substrate. Unlike previously reported membrane-based plasma separators, the separation membrane in our device is positioned at the top of the sandwiched whole blood film to increase the membrane separation capacity and plasma yield. In addition, the device's superhydrophobic characteristics (i) facilitates the formation of well-defined, contracted, thin blood film with a high contact angle; (ii) minimizes biomolecular adhesion to surfaces; (iii) increases blood clotting time; and (iv) reduces blood cell hemolysis. The device demonstrated a "blood in-plasma out" capability, consistently extracting 65 ± 21.5 μL of plasma from 200 μL of whole blood in less than 10 min without electrical power. The device was used to separate plasma from Schistosoma mansoni genomic DNA-spiked whole blood with a recovery efficiency of >84.5 ± 25.8%. The S. mansoni genomic DNA in the separated plasma was successfully tested on our custom-made microfluidic chip by using loop mediated isothermal amplification (LAMP) method. PMID:26732765

  17. High-Gain High-Field Fusion Plasma

    NASA Astrophysics Data System (ADS)

    Li, Ge

    2015-10-01

    A Faraday wheel (FW)—an electric generator of constant electrical polarity that produces huge currents—could be implemented in an existing tokamak to study high-gain high-field (HGHF) fusion plasma, such as the Experimental Advanced Superconducting Tokamak (EAST). HGHF plasma can be realized in EAST by updating its pulsed-power system to compress plasma in two steps by induction fields; high gains of the Lawson trinity parameter and fusion power are both predicted by formulating the HGHF plasma. Both gain rates are faster than the decrease rate of the plasma volume. The formulation is checked by earlier ATC tests. Good agreement between theory and tests indicates that scaling to over 10 T at EAST may be possible by two-step compressions with a compression ratio of the minor radius of up to 3. These results point to a quick new path of fusion plasma study, i.e., simulating the Sun by EAST.

  18. High-Gain High-Field Fusion Plasma.

    PubMed

    Li, Ge

    2015-01-01

    A Faraday wheel (FW)-an electric generator of constant electrical polarity that produces huge currents-could be implemented in an existing tokamak to study high-gain high-field (HGHF) fusion plasma, such as the Experimental Advanced Superconducting Tokamak (EAST). HGHF plasma can be realized in EAST by updating its pulsed-power system to compress plasma in two steps by induction fields; high gains of the Lawson trinity parameter and fusion power are both predicted by formulating the HGHF plasma. Both gain rates are faster than the decrease rate of the plasma volume. The formulation is checked by earlier ATC tests. Good agreement between theory and tests indicates that scaling to over 10 T at EAST may be possible by two-step compressions with a compression ratio of the minor radius of up to 3. These results point to a quick new path of fusion plasma study, i.e., simulating the Sun by EAST. PMID:26507314

  19. Langmuir probe analysis of highly electronegative plasmas

    SciTech Connect

    Bredin, Jerome; Chabert, Pascal; Aanesland, Ane

    2013-04-15

    A Langmuir probe analysis of highly electronegative plasmas is proposed. Analytical models are used to fit the IV-characteristics and their second derivatives above and below the plasma potential. Ion and electron densities are obtained for {alpha} (negative ion to electron density ratio) up to 3000, and the temperature of negative and positive ions is obtained for {alpha} ranging from 100 to 3000. The transport across a localized magnetic barrier is studied using this technique. It is shown that an ion-ion (electron free) plasma is formed downstream from the barrier at the highest magnetic field.

  20. Ultra-high intensity laser plasma interactions

    NASA Astrophysics Data System (ADS)

    Langdon, A. Bruce; Hinkel, D. E.; Lasinski, Barbara F.; Still, C. H.

    1997-11-01

    In current studies of plasma interactions relevant to the fast ignitor concept,footnote M. Tabak, et al., Phys. Plasmas 1, 1626 (1994). an ultra-high intensity beam propagates through underdense, relativistically transparent, and then near solid density plasmas to create a channel. The ultra-high intensity beam propagates through this channel toward the compressed core where it creates hot electrons as it is absorbed. Three-dimensional fluid simulation(R. L. Berger et al), Phys. Fluids B, 2243 (1993). (with relativistic enhancements) studies of self-focusing in the underdense plasma will be reported and compared to PIC simulations in the same parameter regime. Beam structure near focus detracts from channel formation. Modeling in support of upcoming 100TW will be presented.

  1. Phenotyping structural abnormalities in mouse embryos using high-resolution episcopic microscopy

    PubMed Central

    Weninger, Wolfgang J.; Geyer, Stefan H.; Martineau, Alexandrine; Galli, Antonella; Adams, David J.; Wilson, Robert; Mohun, Timothy J.

    2014-01-01

    The arrival of simple and reliable methods for 3D imaging of mouse embryos has opened the possibility of analysing normal and abnormal development in a far more systematic and comprehensive manner than has hitherto been possible. This will not only help to extend our understanding of normal tissue and organ development but, by applying the same approach to embryos from genetically modified mouse lines, such imaging studies could also transform our knowledge of gene function in embryogenesis and the aetiology of developmental disorders. The International Mouse Phenotyping Consortium is coordinating efforts to phenotype single gene knockouts covering the entire mouse genome, including characterising developmental defects for those knockout lines that prove to be embryonic lethal. Here, we present a pilot study of 34 such lines, utilising high-resolution episcopic microscopy (HREM) for comprehensive 2D and 3D imaging of homozygous null embryos and their wild-type littermates. We present a simple phenotyping protocol that has been developed to take advantage of the high-resolution images obtained by HREM and that can be used to score tissue and organ abnormalities in a reliable manner. Using this approach with embryos at embryonic day 14.5, we show the wide range of structural abnormalities that are likely to be detected in such studies and the variability in phenotypes between sibling homozygous null embryos. PMID:25256713

  2. Characteristics of plasma sterilizer using microwave torch plasma with AC high-voltage discharge plasma

    NASA Astrophysics Data System (ADS)

    Itarashiki, Tomomasa; Hayashi, Nobuya; Yonesu, Akira

    2016-01-01

    Microwave plasma sterilization has recently been attracting attention for medical applications. However, it is difficult to perform low-temperature sterilization in short time periods. Increasing the output power shortens the time required for sterilization but causes the temperature to increase. To overcome this issue, we have developed a hybrid plasma system that combines a microwave torch plasma and a high-voltage mesh plasma, which allows radicals to be produced at low temperatures. Using this system, successful sterilization was shown to be possible in a period of 45 min at a temperature of 41 °C.

  3. HIGH ENERGY GASEOUS PLASMA CONTAINMENT DEVICE

    DOEpatents

    Josephson, V.; Hammel, J.E.

    1959-01-13

    An apparatus is presenied for producing neutrons as a result of collisions between ions in high temperature plasmas. The invention resides in the particular arrangement of ihe device whereby ihe magneiic and electric fields are made to cross at substantially right angles in several places along a torus shaped containment vessel. A plasma of deuterium gas is generated in the vessel under the electric fields and is "trapped" in any one of the "crossed field" regions to produce a release of energy.

  4. High-harmonic generation in cavitated plasmas

    SciTech Connect

    Schroeder, C. B.; Esarey, E.; Comier-Michel, E.; Leemans, W. P.

    2008-05-15

    A method is proposed for producing coherent x-rays via high-harmonic generation using ultraintense lasers interacting with highly stripped ions in cavitated plasmas. This method relies on plasma cavitation by the wake of an intense drive beam (laser or electron beam) to produce an ion cavity. An ultrashort pulse laser propagating in the plasma-electron-free ion cavity generates laser harmonics. The longitudinal electron motion, which inhibits high-harmonic generation at high laser intensities, can be suppressed by the space-charge field in the ion cavity or by using a counterpropagating laser pulse. Periodic suppression of the longitudinal electron motion may also be used to quasi-phase-match. This method enables harmonic generation to be extended to the sub-A regime.

  5. High Frequency Plasma Generators for Ion Thrusters

    NASA Technical Reports Server (NTRS)

    Divergilio, W. F.; Goede, H.; Fosnight, V. V.

    1981-01-01

    The results of a one year program to experimentally adapt two new types of high frequency plasma generators to Argon ion thrusters and to analytically study a third high frequency source concept are presented. Conventional 30 cm two grid ion extraction was utilized or proposed for all three sources. The two plasma generating methods selected for experimental study were a radio frequency induction (RFI) source, operating at about 1 MHz, and an electron cyclotron heated (ECH) plasma source operating at about 5 GHz. Both sources utilize multi-linecusp permanent magnet configurations for plasma confinement. The plasma characteristics, plasma loading of the rf antenna, and the rf frequency dependence of source efficiency and antenna circuit efficiency are described for the RFI Multi-cusp source. In a series of tests of this source at Lewis Research Center, minimum discharge losses of 220+/-10 eV/ion were obtained with propellant utilization of .45 at a beam current of 3 amperes. Possible improvement modifications are discussed.

  6. Controlled thermonuclear fusion, high temperature plasma physics

    NASA Astrophysics Data System (ADS)

    1985-05-01

    The primary source of nuclear energy comes from the fission process of heavy nuclei. To utilize the energy released by a thermonuclear fusion process, methods of controlling the fusion reaction were studied. This is controlled thermonuclear fusion technology. The fuel used in a thermonuclear fusion process are isotopes of hydrogen: deuterium and tritium. They can be extracted from the almost unlimited seawater. Nuclear fusion also produces very little radioactive waste. Thermonuclear fusion is a promising energy source with an almost unlimited supply; it is economical, safe, and relatively clean. Ways to raise plasma temperature to a very high level and to maintain it to allow fusion reactions to take place are studied. The physical laws of high temperature plasma was studied to reach this goal which resulted in the development of high temperature plasma physics.

  7. Mathematical impairment associated with high-contrast abnormalities in change detection and magnocellular visual evoked response.

    PubMed

    Jastrzebski, Nicola R; Crewther, Sheila G; Crewther, David P

    2015-10-01

    The cause of developmental dyscalculia, a specific deficit in acquisition of arithmetic skills, particularly of enumeration, has never been investigated with respect to the patency of the visual magnocellular system. Here, the question of dysfunction of the afferent magnocellular cortical input and its dorsal stream projections was tested directly using nonlinear analysis of the visual evoked potential (VEP) and through the psychophysical ability to rapidly detect visual change. A group of young adults with self-reported deficiencies of arithmetical ability, showed marked impairment in magnitude estimation and enumeration performance-though not in lexical decision reaction times when compared with an arithmetically capable group controlled for age and handedness. Multifocal nonlinear VEPs were recorded at low (24 %) and high (96 %) contrast. First- and second-order VEP kernels were comparable between groups at low contrast, but not at high contrast. The mathematically impaired group showed an abnormal lack of contrast saturation in the shortest latency first-order peak (N60) and a delayed P100 positivity in the first slice of the second-order kernel. Both features have previously been argued to be physiological markers of magnocellular function. Mathematically impaired participants also performed worse on a gap paradigm change detection for digit task showing increased reaction times for high-contrast stimuli but not for low-contrast stimuli compared with controls. The VEP results give direct evidence of abnormality in the occipital processing of magnocellular information in those with mathematical impairment. The anomalous high visual contrast physiological and psychophysical performance suggests an abnormality in the inhibitory processes that normally result in saturation of contrast gain in the magnocellular system. PMID:26195163

  8. In-situ observation of abnormal electron temperure in the F-region valley associated with the prereversal enhancement in the vertical plasma drift

    NASA Astrophysics Data System (ADS)

    Muralikrishna, Polinaya; Batista, Inez S.; Odriozola, Siomel

    During one of the post sunset rocket launches made on 18-th December 1995 from the equatorial rocket launching station CLA in Alcântara, Brazil a Langmuir probe measured abnormally large electron temperatures below the F-region just before the onset of plasma bubbles but temperatures became normal soon after the onset of bubbles. In-situ measurements made from Brazil recently using rocket-borne swept-bias Langmuir Probes show that the electron temperatures in the valley region between the equatorial E and F regions get modified before the onset of plasma bubbles, probably associated with the prereversal enhancement in the vertical plasma drift. On 2-nd December 2011 a Brazilian VS-30 single stage rocket was launched from the equatorial rocket launching station CLBI in Natal, Brazil carrying a Langmuir probe operating alternately in swept and constant bias modes to measure both electron temperature and electron density respectively. The ground equipments operated during the rocket launch clearly showed the rapid rise of the F-region base indicating the prereversal enhancement of the F-region vertical drift. At the time of launch the bubble activity was also at its peak. The electron density and temperature height profiles could be estimated from the LP data up to the rocket apogee altitude of 139km. During the rocket upleg and downleg the valley region showed the presence of electron temperatures as high as 2000 ºK while the temperatures expected from the existing models are around 500 ºK. A two stage VS-30/Orion rocket was again launched on 8-th December 2012 soon after sunset carrying a Langmuir Probe operating alternately in swept and constant bias modes. At the time of launch ground equipments operated at equatorial stations showed rapid rise in the base of the F-layer and creating ionospheric conditions favorable for the generation of plasma bubbles. Electron temperatures as high as 3500ºK were observed in the valley region during the rocket upleg and

  9. Abnormal high surface heat flow caused by the Emeishan mantle plume

    NASA Astrophysics Data System (ADS)

    Jiang, Qiang; Qiu, Nansheng; Zhu, Chuanqing

    2016-04-01

    It is commonly believed that increase of heat flow caused by a mantle plume is small and transient. Seafloor heat flow data near the Hawaiian hotspot and the Iceland are comparable to that for oceanic lithosphere elsewhere. Numerical modeling of the thermal effect of the Parana large igneous province shows that the added heat flow at the surface caused by the magmatic underplating is less than 5mW/m2. However, the thermal effect of Emeishan mantle plume (EMP) may cause the surface hear-flow abnormally high. The Middle-Late Emeishan mantle plume is located in the western Yangtze Craton. The Sichuan basin, to the northeast of the EMP, is a superimposed basin composed of Paleozoic marine carbonate rocks and Mesozoic-Cenozoic terrestrial clastic rocks. The vitrinite reflectance (Ro) data as a paleogeothermal indicator records an apparent change of thermal regime of the Sichuan basin. The Ro profiles from boreholes and outcrops which are close to the center of the basalt province exhibit a 'dog-leg' style at the unconformity between the Middle and Upper Permian, and they show significantly higher gradients in the lower subsection (pre-Middle Permian) than the Upper subsection (Upper Permian to Mesozoic). Thermal history inversion based on these Ro data shows that the lower subsection experienced a heat flow peak much higher than that of the upper subsection. The abnormal heat flow in the Sichuan basin is consistent with the EMP in temporal and spatial distribution. The high-temperature magmas from deep mantle brought heat to the base of the lithosphere, and then large amount of heat was conducted upwards, resulting in the abnormal high surface heat flow.

  10. High frequency plasma generator for ion thrusters

    NASA Technical Reports Server (NTRS)

    Goede, H.; Divergilio, W. F.; Fosnight, V. V.; Komatsu, G.

    1984-01-01

    The results of a program to experimentally develop two new types of plasma generators for 30 cm electrostatic argon ion thrusters are presented. The two plasma generating methods selected for this study were by radio frequency induction (RFI), operating at an input power frequency of 1 MHz, and by electron cyclotron heating (ECH) at an operating frequency of 5.0 GHz. Both of these generators utilize multiline cusp permanent magnet configurations for plasma confinement and beam profile optimization. The program goals were to develop a plasma generator possessing the characteristics of high electrical efficiency (low eV/ion) and simplicity of operation while maintaining the reliability and durability of the conventional hollow cathode plasma sources. The RFI plasma generator has achieved minimum discharge losses of 120 eV/ion while the ECH generator has obtained 145 eV/ion, assuming a 90% ion optical transparency of the electrostatic acceleration system. Details of experimental tests with a variety of magnet configurations are presented.

  11. Simulation of High Energy Density Laboratory Plasmas

    NASA Astrophysics Data System (ADS)

    Guzik, Joyce

    2004-05-01

    High Energy Density plasmas are found in astrophysical environments, have been generated in past underground nuclear tests, and can be created in the laboratory by, e.g. laser or pulsed power experiments. These experiments can be used to validate simulation capabilities that are being developed to advance our understanding of plasma physics, and to develop predictive capabilities for HED plasma applications such as fusion energy. In this talk we will briefly introduce the subject of simulating HED plasmas using radiation hydrodynamics codes. We will give examples of simple test problems, showing how a problem is approached, including geometry specifications, simplifying assumptions, zoning, initial and boundary conditions, basic data on opacities and EOS, and illustrate sensitivities of results to variations. We will also show highlights of work at Los Alamos to validate codes, provide basic data, and develop applications, for example: 1) studying phenomena such as Rayleigh-Taylor and Richtmeyer-Meshkov instabilities, ablation, and supersonic jets at the Omega laser in Rochester and the Sandia Z Machine; 2) quantum molecular dynamics simulations which have recently led to a semi-classical, particle-particle particle-mesh code that allows ultra-fast simulations involving tens of thousands of particles to calculate properties of hot dense plasmas; 3) efforts to experimentally demonstrate the physics basis for magnetized target fusion (MTF), a potentially low cost path to fusion, intermediate in plasma regime between magnetic and inertial fusion energy.

  12. LAPTAG High School Plasma Physics laboratory

    NASA Astrophysics Data System (ADS)

    Layton, William; Gekelman, Walter; Pribyl, Patrick

    1999-11-01

    Six years ago an alliance of about thirty high schools and community colleges, and the UCLA physics department was initiated. LAPTAG (Los Angeles teachers Alliance Group) started with laboratory tours, a Web based astronomy course and a seismology project funded by the Office of the President of the University of California. Laptag has a website: [ http://coke.physics.ucla.edu/laptag] in which these projects as well as websites of the individual schools may be found. Recently we were funded by DOE to construct a plasma physics laboratory, which will reside at UCLA, but used by the high school teachers and their students. The machine is presently under construction by a team of eight high school teachers under the supervision of UCLA plasma physicists. The plasma will be generated by a helicon source, and then drift into a field free test chamber surrounded by confining permanent magnets. The preliminary experiments will be on ion acoustic waves and the mapping of the p! lasma potential. Presently we are giving the teachers a summer course in plasma Physics after which they will write a laboratory manual and lecture notes for a high school laboratory based course. In some schools this will be offered as part of an "AP" course and at others as a special laboratory. The courses will be taught by the high school teachers and offered this Fall semester. We will present pictures of the device, preliminary data, and course material.

  13. ACE Reduces Metabolic Abnormalities in a High-Fat Diet Mouse Model

    PubMed Central

    Lee, Seong-Jong; Han, Jong-Min; Lee, Jin-Seok; Son, Chang-Gue; Im, Hwi-Jin; Jo, Hyun-Kyung; Yoo, Ho-Ryong; Kim, Yoon-Sik; Seol, In-Chan

    2015-01-01

    The medicinal plants Artemisia iwayomogi (A. iwayomogi) and Curcuma longa (C. longa) radix have been used to treat metabolic abnormalities in traditional Korean medicine and traditional Chinese medicine (TKM and TCM). In this study we evaluated the effect of the water extract of a mixture of A. iwayomogi and C. longa (ACE) on high-fat diet-induced metabolic syndrome in a mouse model. Four groups of C57BL/6N male mice (except for the naive group) were fed a high-fat diet freely for 10 weeks. Among these, three groups (except the control group) were administered a high-fat diet supplemented with ACE (100 or 200 mg/kg) or curcumin (50 mg/kg). Body weight, accumulation of adipose tissues in abdomen and size of adipocytes, serum lipid profiles, hepatic steatosis, and oxidative stress markers were analyzed. ACE significantly reduced the body and peritoneal adipose tissue weights, serum lipid profiles (total cholesterol and triglycerides), glucose levels, hepatic lipid accumulation, and oxidative stress markers. ACE normalized lipid synthesis-associated gene expressions (peroxisome proliferator-activated receptor gamma, PPARγ; fatty acid synthase, FAS; sterol regulatory element-binding transcription factor-1c, SREBP-1c; and peroxisome proliferator-activated receptor alpha, PPARα). The results from this study suggest that ACE has the pharmaceutical potential reducing the metabolic abnormalities in an animal model. PMID:26508977

  14. Abnormal effective connectivity and psychopathological symptoms in the psychosis high-risk state

    PubMed Central

    Schmidt, André; Smieskova, Renata; Simon, Andor; Allen, Paul; Fusar-Poli, Paolo; McGuire, Philip K.; Bendfeldt, Kerstin; Aston, Jacqueline; Lang, Undine E.; Walter, Marc; Radue, Ernst-Wilhelm; Riecher-Rössler, Anita; Borgwardt, Stefan J.

    2014-01-01

    Background Recent evidence has revealed abnormal functional connectivity between the frontal and parietal brain regions during working memory processing in patients with schizophrenia and first-episode psychosis. However, it still remains unclear whether abnormal frontoparietal connectivity during working memory processing is already evident in the psychosis high-risk state and whether the connection strengths are related to psychopathological outcomes. Methods Healthy controls and antipsychotic-naive individuals with an at-risk mental state (ARMS) performed an n-back working memory task while undergoing functional magnetic resonance imaging. Effective connectivity between frontal and parietal brain regions during working memory processing were characterized using dynamic causal modelling. Results Our study included 19 controls and 27 individuals with an ARMS. In individuals with an ARMS, we found significantly lower task performances and reduced activity in the right superior parietal lobule and middle frontal gyrus than in controls. Furthermore, the working memory–induced modulation of the connectivity from the right middle frontal gyrus to the right superior parietal lobule was significantly reduced in individuals with an ARMS, while the extent of this connectivity was negatively related to the Brief Psychiatric Rating Scale total score. Limitations The modest sample size precludes a meaningful subgroup analysis for participants with a later transition to psychosis. Conclusion This study demonstrates that abnormal frontoparietal connectivity during working memory processing is already evident in individuals with an ARMS and is related to psychiatric symptoms. Thus, our results provide further insight into the pathophysiological mechanisms of the psychosis high-risk state by linking functional brain imaging, computational modelling and psychopathology. PMID:24506946

  15. High beta plasmas in the PBX tokamak

    SciTech Connect

    Bol, K.; Buchenauer, D.; Chance, M.; Couture, P.; Fishman, H.; Fonck, R.; Gammel, G.; Grek, B.; Ida, K.; Itami, K.

    1986-04-01

    Bean-shaped configurations favorable for high ..beta.. discharges have been investigated in the Princeton Beta Experiment (PBX) tokamak. Strongly indented bean-shaped plasmas have been successfully formed, and beta values of over 5% have been obtained with 5 MW of injected neutral beam power. These high beta discharges still lie in the first stability regime for ballooning modes, and MHD stability analysis implicates the external kink as responsible for the present ..beta.. limit.

  16. Left-Hemispheric Microstructural Abnormalities in Children With High Functioning Autism Spectrum Disorder

    PubMed Central

    Peterson, Daniel; Mahajan, Rajneesh; Crocetti, Deana; Mejia, Amanda; Mostofsky, Stewart

    2014-01-01

    Current theories of the neurobiological basis of Autism Spectrum Disorder (ASD) posit an altered pattern of connectivity in large-scale brain networks. Here we used Diffusion Tensor Imaging to investigate the microstructural properties of the white matter that mediates inter-regional connectivity in 36 high-functioning children with ASD (HF-ASD), as compared to 37 controls. By employing an atlas-based analysis using LDDMM registration, a widespread, but left-lateralized pattern of abnormalities was revealed. The Mean Diffusivity (MD) of water in the white matter of HF-ASD children was significantly elevated throughout the left hemisphere, particularly in the outer-zone cortical white matter. Across diagnostic groups there was a significant effect of age on left hemisphere MD, with a similar reduction in MD during childhood in both TD and HF-ASD children. The increased MD in children with HF-ASD suggests hypomyelination, and may reflect increased short-range cortico-cortical connections subsequent to early white matter overgrowth. These findings also highlight left hemispheric connectivity as relevant to the pathophysiology of ASD, and indicate that the spatial distribution of microstructural abnormalities in HF-ASD is widespread, and left-lateralized. This altered left-hemispheric connectivity may contribute to deficits in communication and praxis observed in ASD. PMID:25256103

  17. High-Gain High-Field Fusion Plasma

    PubMed Central

    Li, Ge

    2015-01-01

    A Faraday wheel (FW)—an electric generator of constant electrical polarity that produces huge currents—could be implemented in an existing tokamak to study high-gain high-field (HGHF) fusion plasma, such as the Experimental Advanced Superconducting Tokamak (EAST). HGHF plasma can be realized in EAST by updating its pulsed-power system to compress plasma in two steps by induction fields; high gains of the Lawson trinity parameter and fusion power are both predicted by formulating the HGHF plasma. Both gain rates are faster than the decrease rate of the plasma volume. The formulation is checked by earlier ATC tests. Good agreement between theory and tests indicates that scaling to over 10 T at EAST may be possible by two-step compressions with a compression ratio of the minor radius of up to 3. These results point to a quick new path of fusion plasma study, i.e., simulating the Sun by EAST. PMID:26507314

  18. High-frequency plasma-heating apparatus

    DOEpatents

    Brambilla, Marco; Lallia, Pascal

    1978-01-01

    An array of adjacent wave guides feed high-frequency energy into a vacuum chamber in which a toroidal plasma is confined by a magnetic field, the wave guide array being located between two toroidal current windings. Waves are excited in the wave guide at a frequency substantially equal to the lower frequency hybrid wave of the plasma and a substantially equal phase shift is provided from one guide to the next between the waves therein. For plasmas of low peripheral density gradient, the guides are excited in the TE.sub.01 mode and the output electric field is parallel to the direction of the toroidal magnetic field. For exciting waves in plasmas of high peripheral density gradient, the guides are excited in the TM.sub.01 mode and the magnetic field at the wave guide outlets is parallel to the direction of the toroidal magnetic field. The wave excited at the outlet of the wave guide array is a progressive wave propagating in the direction opposite to that of the toroidal current and is, therefore, not absorbed by so-called "runaway" electrons.

  19. High voltage system: Plasma interaction summary

    NASA Technical Reports Server (NTRS)

    Stevens, N. John

    1986-01-01

    The possible interactions that could exist between a high voltage system and the space plasma environment are reviewed. A solar array is used as an example of such a system. The emphasis in this review is on the discrepancies that exist in this technology in both flight and ground experiment data. It has been found that, in ground testing, there are facility effects, cell size effects and area scaling uncertainties. For space applications there are area scaling and discharge concerns for an array as well as the influence of the large space structures on the collection process. There are still considerable uncertainties in the high voltage-space plasma interaction technology even after several years of effort.

  20. The integrated method to select drilling muds for abnormally high pressure formations

    NASA Astrophysics Data System (ADS)

    Khorev, V. S.; Dmitriev, A. Yu; Boyko, I. A.; Kayumova, N. S.; Rakhimov, T. R.

    2016-03-01

    The article describes the method for choosing a drilling mud for drilling abnormally high pressure formations. A carefully selected drilling mud formulation would not only enhance an array of interrelated fluid properties, but also minimize the impact on the pay zones when the drill bit first penetrates the pay. To ensure a better assessment of drilling mud impact on the pay zone, it is reasonable to carry out the study focused on the analysis of technological parameters, involving filtration, acid and drilling mud tests, as well as formation damage analysis. This would enable evaluating the degree of mudding off, reservoirs acid fracturing effect and the risks of pipe sticking at significant depth. The article presents the results of the above-described study with regard to the currently used drilling mud and new experimental formulations developed at National Research Tomsk Polytechnic University (Drilling Mud and Cement Slurry Laboratory).

  1. High Current Hollow Cathode Plasma Plume Measurements

    NASA Technical Reports Server (NTRS)

    Thomas, Robert E.; Kamhawi, Hani; Williams, George J., Jr.

    2014-01-01

    Plasma plume measurements are reported for a hollow cathode assembly (HCA) operated at discharge currents of 50, 70, and 100 A at xenon flow rates between 19 - 46 standard cubic centimeter per minute. The HCA was centrally mounted in the NASA-300MS Hall Thruster and was operated in the "spot" and "plume" modes with additional data taken with an applied magnetic field. Langmuir probes, retarding potential analyzers, and optical emission spectroscopy were employed to measure plasma properties near the orifice of the HCA and to assess the charge state of the near-field plasma. Electron temperatures (2-6 electron volt) and plasma potentials are consistent with probe-measured values in previous investigations. Operation with an applied-field yields higher discharge voltages, increased Xe III production, and increased signals from the 833.5 nm C I line. While operating in plume mode and with an applied field, ion energy distribution measurements yield ions with energies significantly exceeding the applied discharge voltage. These findings are correlated with high-frequency oscillations associated with each mode.

  2. Dietary high-fat lard intake induces thyroid dysfunction and abnormal morphology in rats

    PubMed Central

    Shao, Shan-shan; Zhao, Yuan-fei; Song, Yong-feng; Xu, Chao; Yang, Jian-mei; Xuan, Shi-meng; Yan, Hui-li; Yu, Chun-xiao; Zhao, Meng; Xu, Jin; Zhao, Jia-jun

    2014-01-01

    Aim: Excess dietary fat intake can induce lipotoxicity in non-adipose tissues. The aim of this study was to observe the effects of dietary high-fat lard intake on thyroid in rats. Methods: Male Sprague-Dawley rats were fed a high-fat lard diet for 24 weeks, and then the rats were fed a normal control diet (acute dietary modification) or the high-fat lard diet for another 6 weeks. The serum lipid profile, total thyroxine (TT4), free thyroxine (FT4) and thyrotropin (TSH) levels were determined at the 12, 18, 24 and 30 weeks. High-frequency ultrasound scanning of the thyroid glands was performed at the 24 or 30 weeks. After the rats were sacrificed, the thyroid glands were collected for histological and immunohistochemical analyses. Results: The high-fat lard diet significantly increased triglyceride levels in both the serum and thyroid, and decreased serum TT4 and FT4 levels in parallel with elevated serum TSH levels. Ultrasonic imaging revealed enlarged thyroid glands with lowered echotexture and relatively heterogeneous features in the high-fat lard fed rats. The thyroid glands from the high-fat lard fed rats exhibited enlarged follicle cavities and flattened follicular epithelial cells under light microscopy, and dilated endoplasmic reticulum cisternae, twisted nuclei, fewer microvilli and secretory vesicles under transmission electron microscopy. Furthermore, the thyroid glands from the high-fat lard fed rats showed markedly low levels of thyroid hormone synthesis-related proteins TTF-1 and NIS. Acute dietary modification by withdrawal of the high-fat lard diet for 6 weeks failed to ameliorate the high-fat lard diet-induced thyroid changes. Conclusion: Dietary high-fat lard intake induces significant thyroid dysfunction and abnormal morphology in rats, which can not be corrected by short-term dietary modification. PMID:25263336

  3. Laser Plasma Coupling for High Temperature Hohlraums

    SciTech Connect

    Kruer, W.

    1999-11-04

    Simple scaling models indicate that quite high radiation temperatures can be achieved in hohlraums driven with the National Ignition Facility. A scaling estimate for the radiation temperature versus pulse duration for different size NIF hohlraums is shown in Figure 1. Note that a radiation temperature of about 650 ev is projected for a so-called scale 1 hohlraum (length 2.6mm, diameter 1.6mm). With such high temperature hohlraums, for example, opacity experiments could be carried out using more relevant high Z materials rather than low Z surrogates. These projections of high temperature hohlraums are uncertain, since the scaling model does not allow for the very strongly-driven laser plasma coupling physics. Lasnex calculations have been carried out to estimate the plasma and irradiation conditions in a scale 1 hohlraum driven by NIF. Linear instability gains as high as exp(100) have been found for stimulated Brillouin scattering, and other laser-driven instabilities are also far above their thresholds. More understanding of the very strongly-driven coupling physics is clearly needed in order to more realistically assess and improve the prospects for high temperature hohlraums. Not surprisingly, this regime has been avoided for inertial fusion applications and so is relatively unexplored.

  4. Network Mechanisms Generating Abnormal and Normal Hippocampal High-Frequency Oscillations: A Computational Analysis1,2,3

    PubMed Central

    Gliske, Stephen; Catoni, Nicholas

    2015-01-01

    Abstract High-frequency oscillations (HFOs) are an intriguing potential biomarker for epilepsy, typically categorized according to peak frequency as either ripples (100–250 Hz) or fast ripples (>250 Hz). In the hippocampus, fast ripples were originally thought to be more specific to epileptic tissue, but it is still very difficult to distinguish which HFOs are caused by normal versus pathological brain activity. In this study, we use a computational model of hippocampus to investigate possible network mechanisms underpinning normal ripples, pathological ripples, and fast ripples. Our results unify several prior findings regarding HFO mechanisms, and also make several new predictions regarding abnormal HFOs. We show that HFOs are generic, emergent phenomena whose characteristics reflect a wide range of connectivity and network input. Although produced by different mechanisms, both normal and abnormal HFOs generate similar ripple frequencies, underscoring that peak frequency is unable to distinguish the two. Abnormal ripples are generic phenomena that arise when input to pyramidal cells overcomes network inhibition, resulting in high-frequency, uncoordinated firing. In addition, fast ripples transiently and sporadically arise from the precise conditions that produce abnormal ripples. Lastly, we show that such abnormal conditions do not require any specific network structure to produce coherent HFOs, as even completely asynchronous activity is capable of producing abnormal ripples and fast ripples in this manner. These results provide a generic, network-based explanation for the link between pathological ripples and fast ripples, and a unifying description for the entire spectrum from normal ripples to pathological fast ripples. PMID:26146658

  5. High frequency of p53/MDM2/p14ARF pathway abnormalities in relapsed neuroblastoma

    PubMed Central

    Carr-Wilkinson, Jane; O' Toole, Kieran; Wood, Katrina M.; Challen, Christine C.; Baker, Angela G.; Board, Julian R.; Evans, Laura; Cole, Michael; Cheung, Nai-Kong V.; Boos, Joachim; Köhler, Gabriele; Leuschner, Ivo; Pearson, Andrew D.J.; Lunec, John; Tweddle, Deborah A.

    2010-01-01

    Purpose: Most neuroblastomas initially respond to therapy but many relapse with chemoresistant disease. p53 mutations are rare in diagnostic neuroblastomas, but we have previously reported inactivation of the p53/MDM2/p14ARF pathway in 9/17 (53%) neuroblastoma cell lines established at relapse. Hypothesis: Inactivation of the p53/MDM2/p14ARF pathway develops during treatment and contributes to neuroblastoma relapse. Methods: Eighty-four neuroblastomas were studied from 41 patients with relapsed neuroblastoma including 38 paired neuroblastomas at different stages of therapy. p53 mutations were detected by automated sequencing, p14ARF methylation and deletion by methylation-specific PCR and duplex PCR respectively, and MDM2 amplification by fluorescent in-situ hybridisation. Results: Abnormalities in the p53 pathway were identified in 20/41(49%) cases. Downstream defects due to inactivating missense p53 mutations were identified in 6/41 (15%) cases, 5 following chemotherapy and/or at relapse and 1 at diagnosis, post chemotherapy and relapse. The presence of a p53 mutation was independently prognostic for overall survival (hazard ratio 3.4, 95% confidence interval 1.2, 9.9; p = 0.02). Upstream defects were present in 35% cases: MDM2 amplification in 3 cases, all at diagnosis & relapse and p14ARF inactivation in 12/41 (29%) cases: 3 had p14ARF methylation, 2 after chemotherapy, and 9 had homozygous deletions, 8 at diagnosis and relapse. Conclusions: These results show that a high proportion of neuroblastomas which relapse have an abnormality in the p53 pathway. The majority have upstream defects suggesting that agents which reactivate wild-type p53 would be beneficial, in contrast to those with downstream defects where p53 independent therapies are indicated. PMID:20145180

  6. High density plasma etching of magnetic devices

    NASA Astrophysics Data System (ADS)

    Jung, Kee Bum

    Magnetic materials such as NiFe (permalloy) or NiFeCo are widely used in the data storage industry. Techniques for submicron patterning are required to develop next generation magnetic devices. The relative chemical inertness of most magnetic materials means they are hard to etch using conventional RIE (Reactive Ion Etching). Therefore ion milling has generally been used across the industry, but this has limitations for magnetic structures with submicron dimensions. In this dissertation, we suggest high density plasmas such as ECR (Electron Cyclotron Resonance) and ICP (Inductively Coupled Plasma) for the etching of magnetic materials (NiFe, NiFeCo, CoFeB, CoSm, CoZr) and other related materials (TaN, CrSi, FeMn), which are employed for magnetic devices like magnetoresistive random access memories (MRAM), magnetic read/write heads, magnetic sensors and microactuators. This research examined the fundamental etch mechanisms occurring in high density plasma processing of magnetic materials by measuring etch rate, surface morphology and surface stoichiometry. However, one concern with using Cl2-based plasma chemistry is the effect of residual chlorine or chlorinated etch residues remaining on the sidewalls of etched features, leading to a degradation of the magnetic properties. To avoid this problem, we employed two different processing methods. The first one is applying several different cleaning procedures, including de-ionized water rinsing or in-situ exposure to H2, O2 or SF6 plasmas. Very stable magnetic properties were achieved over a period of ˜6 months except O2 plasma treated structures, with no evidence of corrosion, provided chlorinated etch residues were removed by post-etch cleaning. The second method is using non-corrosive gas chemistries such as CO/NH3 or CO2/NH3. There is a small chemical contribution to the etch mechanism (i.e. formation of metal carbonyls) as determined by a comparison with Ar and N2 physical sputtering. The discharge should be NH3

  7. Association of high viral load and abnormal liver function with high aflatoxin B1–albumin adduct levels in HIV-positive Ghanaians: preliminary observations

    PubMed Central

    Jolly, P.E.; Shuaib, F.M.; Jiang, Y.; Preko, P.; Baidoo, J.; Stiles, J.K.; Wang, J.-S.; Phillips, T.D.; Williams, J.H.

    2012-01-01

    We examined the association between certain clinical factors and aflatoxin B1–albumin adduct (AF-ALB) levels in HIV-positive people. Plasma samples collected from 314 (155 HIV-positive and 159 HIV-negative) people were tested for AF-ALB levels, viral load, CD4+ T-cell count, liver function profile, malaria parasitaemia, and hepatitis B and C virus infections. HIV-positive participants were divided into high and low groups based on their median AF-ALB of 0.93 pmol mg−1 albumin and multivariable logistic and linear regression methods used to assess relationships between clinical conditions and AF-ALB levels. Multivariable logistic regression showed statistically significant increased odds of having higher HIV viral loads (OR=2.84; 95% CI=1.17–7.78) and higher direct bilirubin levels (OR=5.47; 95% CI=1.03–22.85) among HIV-positive participants in the high AF-ALB group. There were also higher levels of total bilirubin and lower levels of albumin in association with high AF-ALB. Thus, aflatoxin exposure may contribute to high viral loads and abnormal liver function in HIV-positive people and so promote disease progression. PMID:21749228

  8. Abnormal high-Q modes of coupled stadium-shaped microcavities.

    PubMed

    Ryu, Jung-Wan; Lee, Soo-Young; Kim, Inbo; Choi, Muhan; Hentschel, Martina; Kim, Sang Wook

    2014-07-15

    It is well known that the strongly deformed microcavity with fully chaotic ray dynamics cannot support high-Q modes due to its fast chaotic diffusion to the critical line of refractive emission. Here, we investigate how the Q factor is modified when two chaotic cavities are coupled, and show that some modes, whose Q factor is about 10 times higher than that of the corresponding single cavity, can exist. These abnormal high-Q modes are the result of an optimal combination of coupling and cavity geometry. As an example, in the coupled stadium-shaped microcavities, the mode pattern extends over both cavities such that it follows a whispering-gallery-type mode at both ends, whereas a big coupling spot forms at the closest contact of the two microcavities. The pattern of such a "rounded bow tie" mode allows the mode to have a high-Q factor. This mode pattern minimizes the leakage of light at both ends of the microcavities as the pattern at both ends is similar to the whispering gallery mode. PMID:25121685

  9. Atomic processes in high temperature plasmas

    SciTech Connect

    Hahn, Y.

    1991-07-01

    This is the final report on the project Atomic Processes in High Temperature Plasmas', which has been completed in June 30, 1991. The original contract started in 1978. The dielectronic recombination (DR) rate coefficients were calculated for ions with the number of electrons N = 1, 2, 3, 4, 5, 10, 11, and 12. The result was then used to construct a new and improved rate formula. Other important resonant processes, which are closely related to DR, were also studied to interpret experiments and to test the DR theory. The plasma field and the density effects on the rate coefficients was found to be important, and a consistent correction procedure is being developed. The available data on the DR rates and their accuracy do not yet fully meet the requirement for plasma modeling; there are serious gaps in the available data, and the currently adopted theoretical procedure needs improvements. Critical assessment of the current status of the DR problem is presented, and possible future work needed is summarized.

  10. High Current Hollow Cathode Plasma Plume Measurements

    NASA Technical Reports Server (NTRS)

    Thomas, Robert E.; Kamhawi, Hani; Williams, George J., Jr.

    2013-01-01

    Plasma plume measurements are reported for a hollow cathode assembly (HCA) oper-ated at discharge currents of 50, 70, and 100 A at xenon ow rates between 19 - 46 sccm.The HCA was centrally mounted in the annulus of the NASA-300MS Hall Thruster andwas operated in the spot and plume modes with additional data taken with an appliedmagnetic eld. Langmuir probes, retarding potential analyzers, and optical emission spec-troscopy were employed to measure plasma properties near the orice of the HCA and toassess the charge state of the near-eld plasma. Electron temperatures (2-6 eV) and plasmapotentials are consistent with probe-measured values in previous investigations. Operationwith an applied-eld yields higher discharge voltages, increased Xe III production, andincreased signals from the 833.5 nm C I line. While operating in plume mode and with anapplied eld, ion energy distribution measurements yield ions with energies signicantlyexceeding the applied discharge voltage. These ndings are correlated with high-frequencyoscillations associated with each mode.

  11. Plasma cleaning device. [designed for high vacuum environments

    NASA Technical Reports Server (NTRS)

    Shannon, R. L.; Gillette, R. B. (Inventor)

    1978-01-01

    High vacuum cleaning of contaminated surfaces such as hydrocarbon containment films can be accomplished by a plasma cleaning device which includes a plasma discharge housing to permit generation of a plasma in an environment having a higher pressure than the surface which is to be cleaned. A ground electrode and a radio frequency electrode partially surround a quartz plasma tube, for the introduction of an ionizable gas. These electrodes ionize the gas and help generate the plasma. This plasma flows through a non-constrictive aperture, through the plasma discharge housing and then on to the contaminated surface.

  12. Center for High Temperature Plasma Physics certified

    NASA Astrophysics Data System (ADS)

    Hu, Maolian

    1985-05-01

    The construction and functions of a research center for high temperature plasma physics and controlled thermonuclear fusion are discussed. It has four of China's largest d.c. pulse generators capable of producing 80 megawatts of power, an induction coil capable of storing 200 million joules of electric energy, and a capacitor bank that can store 8 million joules of energy. It has equipment for producing deionized water, low temperature equipment, a cooling system using refrigerated circulating water, and a heat supply system. The center is one of China's important bases for thermonuclear fusion research.

  13. Device for plasma confinement and heating by high currents and nonclassical plasma transport properties

    DOEpatents

    Coppi, B.; Montgomery, D.B.

    1973-12-11

    A toroidal plasma containment device having means for inducing high total plasma currents and current densities and at the same time emhanced plasma heating, strong magnetic confinement, high energy density containment, magnetic modulation, microwaveinduced heating, and diagnostic accessibility is described. (Official Gazette)

  14. Reproductive and behavioral abnormalities in tree swallows with high levels of PCB contamination

    SciTech Connect

    McCarty, J.; Secord, A.; Tillitt, D.

    1995-12-31

    Tree Swallows (Tachycineta bicolor) breeding along the Hudson River forage extensively on PCB contaminated insects that emerge from the river. The authors studied the reproductive ecology and behavior of tree swallows breeding at several sites along the Hudson River. These sites vary in the severity of PCB contamination. PCB levels in both eggs and chicks were found to be among the highest ever reported in this species, with concentrations comparable to those found in aquatic organisms in the Hudson River. In 1994 reproductive success at PCB contaminated sites was significantly impaired, relative to other sites in New York. Reduced reproductive success was largely attributed to high levels of nest abandonment during incubation and reduced hatchability of eggs. Growth and development of nestlings was not significantly impaired. Abnormal nest building behavior was also noted in 1994, and this was studied in detail in 1995. Nests from contaminated areas are significantly smaller than those at a nearby reference site and at other sites in New York. The authors suggest that the reduced reproductive outputs at these sites are, in large part, a result of effects on the behavior of incubating females. The population-level implications of these patterns are unknown.

  15. High-current plasma contactor neutralizer system

    NASA Technical Reports Server (NTRS)

    Beattie, J. R.; Williamson, W. S.; Matossian, J. N.; Vourgourakis, E. J.; Burch, J. L.

    1989-01-01

    A plasma-contactor neutralizer system is described, for the stabilizing the Orbiter's potential during flights of the Atmospheric Laboratory for Applications and Science missions. The plasma contactor neutralizer will include a Xe plasma source that can provide steady-state ion-emission currents of up to 1.5 A. The Orbiter's potential will be maintained near that of the surrounding space plasma during electron-beam accelerator firings through a combination of ion emission from the Xe plasma source and electron collection from the ambient space plasma. Configuration diagrams and block diagrams are presented along with the performance characteristics of the system.

  16. High prevalence of anterolateral ligament abnormalities in magnetic resonance images of anterior cruciate ligament-injured knees.

    PubMed

    Claes, Steven; Bartholomeeusen, Stijn; Bellemans, Johan

    2014-03-01

    The purpose of this study was to identify the newly described anterolateral ligament of the human knee on magnetic resonance imaging and to describe its eventual radiological abnormalities in anterior cruciate ligament-injured subjects. A retrospective cohort study on a series of consecutive subjects undergoing anterior cruciate ligament reconstructive surgery was performed. The MR images of 206 included knees were studied and the status of the anterolateral ligament status was judged to be either "non-visualized", "normal" or "abnormal". Of all the visualized anterolateral ligaments, 44 (21.3%) were considered uninjured, while 162 (78.8%) knees demonstrated radiological ALL abnormalities. The majority of ALL abnormalities were situated in the distal part of the ligament (77.8%). In conclusion, the anterolateral ligament can be identified on classic knee magnetic resonance images. Although anterior cruciate ligament injured subjects often demonstrated associated anterolateral ligament lesions, further research is needed in order to establish the clinical relevance of these highly frequent radiological abnormalities. PMID:24873084

  17. Kinetic equilibria of very high- β plasmas

    NASA Astrophysics Data System (ADS)

    Steinhauer, Loren; TAE Team

    2015-11-01

    Plasma equilibria with many large ion orbits, such as an advanced beam-driven field-reversed configuration, are neither static (Grad-Shafranov) nor describable as a flowing, multi-fluid. A fully-kinetic treatment of the ions is essential for such high- β plasmas. A kinetic equilibrium is needed to properly support realistic stability and transport analyses, both of which are strongly affected by large-orbit ions. A hybrid equilibrium model has been developed with a fully-kinetic treatment of both thermal ions and a rapidly-rotating ``beam-ion'' component, such as produced by neutral beam injection, relevant to the C-2U experiments at TAE. It employs analytic Vlasov solutions in that the distribution depends only on the two constants of motion, the Hamiltonian (H) and the canonical angular momentum (Pθ) . Electrons are treated as a pressure-bearing fluid. Since realistic forms of f (H ,Pθ) are affected by collisions, f is limited to solutions of a simplified Fokker-Planck equation. Importantly, a kinetic end-loss condition applies to unconfined ions, using a particle sink at a rate consistent with Monte-Carlo-like simulations of end loss accounting for a strong end mirror.

  18. X-ray emission from high temperature plasmas

    NASA Technical Reports Server (NTRS)

    Harries, W. L.

    1977-01-01

    The physical processes occurring in plasma focus devices were investigated with particular emphasis on X-ray emission. Topics discussed include: trajectories of high energy electrons; detection of ion trajectories; spatial distribution of neutron emission; space and time resolved emission of hard X-rays from a plasma focus; the staged plasma focus as a variation of the hypocloidal pinch; formation of current sheets in a staged plasma focus; and X-ray and neutron emission from a staged plasma focus. The possibility of operating dense plasma-focus type devices in multiple arrays beyond the scaling law for a single gun is discussed.

  19. Observations of high-beta toroidal plasmas

    NASA Astrophysics Data System (ADS)

    Halle, J. H.; Kellman, A. G.; Post, R. S.; Prager, S. C.; Strait, E. J.; Zarnstorff, M. C.

    1981-05-01

    A range of MHD stable high-beta plasmas is attained both in the kinetic regime with beta equal to 33% (nine times the fluid ballooning limit) and near the single-fluid regime with beta equal to 8% (twice the theoretical limit). It is found that MHD theory is inadequate and that kinetic effects are apparently more powerful than is generally assumed. It is pointed out that since a reactor (with trapped particles, large-gyroradii ions from neutral beams) may be no more fluid-like than the octupole experiments, their designs should perhaps not necessarily be constrained by the MHD ballooning instability beta limit. Diamagnetic current measurements are found to agree roughly with single-fluid results in the fluid-like case but to depart sharply in the kinetic regime.

  20. High latitude electromagnetic plasma wave emissions

    NASA Technical Reports Server (NTRS)

    Gurnett, D. A.

    1983-01-01

    The principal types of electromagnetic plasma wave emission produced in the high latitude auroral regions are reviewed. Three types of radiation are described: auroral kilometric radiation, auroral hiss, and Z mode radiation. Auroral kilometric radiation is a very intense radio emission generated in the free space R-X mode by electrons associated with the formation of discrete auroral arcs in the local evening. Theories suggest that this radiation is an electron cyclotron resonance instability driven by an enhanced loss cone in the auroral acceleration region at altitudes of about 1 to 2 R sub E. Auroral hiss is a somewhat weaker whistler mode emission generated by low energy (100 eV to 10 keV) auroral electrons. The auroral hiss usually has a V shaped frequency time spectrum caused by a freqency dependent beaming of the whistler mode into a conical beam directed upward or downward along the magnetic field.

  1. High velocity pulsed plasma thermal spray

    NASA Astrophysics Data System (ADS)

    Witherspoon, F. D.; Massey, D. W.; Kincaid, R. W.; Whichard, G. C.; Mozhi, T. A.

    2002-03-01

    The quality and durability of coatings produced by many thermal spray techniques could be improved by increasing the velocity with which coating particles impact the substrate. Additionally, better control of the chemical and thermal environment seen by the particles during flight is crucial to the quality of the coating. A high velocity thermal spray device is under development through a Ballistic Missile Defense Organization Small Business Innovation Research (SBIR) project, which provides significantly higher impact velocity for accelerated particles than is currently available with existing thermal spray devices. This device utilizes a pulsed plasma as the accelerative medium for powders introduced into the barrel. Recent experiments using a particle imaging diagnostic system showed that the device can accelerate stainless steel and WC-Co powders to velocities ranging from 1500 to 2200 m/s. These high velocities are accomplished without the use of combustible gases and without the need of a vacuum chamber, while maintaining an inert atmosphere for the particles during acceleration. The high velocities corresponded well to modeling predictions, and these same models suggest that velocities as high as 3000 m/s or higher are possible.

  2. High efficiency ionizer using a hollow cathode discharge plasma

    SciTech Connect

    Alessi, J.G.; Prelec, K.

    1984-01-01

    A proposal for an ionizer using a hollow cathode discharge plasma is described. Ionization is via the very high current density electron beam component in the plasma, as well as from charge exchange with plasma ions. Extraction of a He/sup +/ current corresponding to approximately 50% of the incoming atomic beam flux should be possible.

  3. New plasma instruments for investigations of plasma distributions with high temporal and phase space coverage

    NASA Astrophysics Data System (ADS)

    Vaisberg, O.

    Evolution of corpuscular diagnostics of space plasmas led to development of very sophisticated plasma spectrometers. There are very specialized spectrometers providing unique identification of mass, energy and charge. Top-hat analyzer became the working horse of contemporary plasma diagnostics on most of spin-stabilized spacecraft. Miniaturized plasma analyzers are developed for new low-cost missions. Still there is a need for instruments with higher temporal resolution and better phase space coverage. Representative examples of high-end plasma analyzers are presented and the trends in corpuscular diagnostics of space plasma are discussed. The new type of plasma analyzer CAMERA is described that allows fast measurements on stabilized or rotating spacecraft. It provides instantaneous 2π field of view without gaps, flexible control of the energy bandwidth and angular resolution, high temporal resolution, and high UV rejection. CAMERA can be used as a feeding optics for additional analyzers including mass-spectrometers.

  4. Longxuetongluo Capsule Improves Erythrocyte Function against Lipid Peroxidation and Abnormal Hemorheological Parameters in High Fat Diet-Induced ApoE−/− Mice

    PubMed Central

    Zheng, Jiao; Liu, Binglin; Lun, Qixing; Yao, Weijuan; Zhao, Yunfang; Xiao, Wei; Huang, Wenzhe; Wang, Yonghua; Li, Jun; Tu, Pengfei

    2016-01-01

    Chinese dragon's blood, the red resin of Dracaena cochinchinensis, one of the renowned traditional medicines, has been used to facilitate blood circulation and disperse blood stasis for thousands of years. Phenolic compounds are considered to be responsible for its main biological activities. In this study, total phenolic compounds of Chinese dragon's blood were made into capsule (Longxuetongluo Capsule, LTC) and their effects on the abnormal hemorheological properties were examined by high fat diet (HFD) induced ApoE−/− mice. Compared to the model group, LTC recovered the abnormal hemorheological parameters in HFD-induced ApoE−/− mice by reducing whole blood viscosity (WBV) at high rate and improving erythrocyte function. In conclusion, LTC could ameliorate erythrocyte deformability and osmotic fragility through the reduction of lipid peroxidation on plasma and erythrocyte membranes in HFD-induced ApoE−/− mice, which supported the traditional uses of Chinese dragon's blood as an effective agent for improving blood microcirculation in hypercholesterolemia. PMID:26649134

  5. Multi-gap high impedance plasma opening switch

    DOEpatents

    Mason, Rodney J.

    1996-01-01

    A high impedance plasma opening switch having an anode and a cathode and at least one additional electrode placed between the anode and cathode. The presence of the additional electrodes leads to the creation of additional plasma gaps which are in series, increasing the net impedance of the switch. An equivalent effect can be obtained by using two or more conventional plasma switches with their plasma gaps wired in series. Higher impedance switches can provide high current and voltage to higher impedance loads such as plasma radiation sources.

  6. Multi-gap high impedance plasma opening switch

    DOEpatents

    Mason, R.J.

    1996-10-22

    A high impedance plasma opening switch having an anode and a cathode and at least one additional electrode placed between the anode and cathode is disclosed. The presence of the additional electrodes leads to the creation of additional plasma gaps which are in series, increasing the net impedance of the switch. An equivalent effect can be obtained by using two or more conventional plasma switches with their plasma gaps wired in series. Higher impedance switches can provide high current and voltage to higher impedance loads such as plasma radiation sources. 12 figs.

  7. High Goblet Cell Count Is Inversely Associated with Ploidy Abnormalities and Risk of Adenocarcinoma in Barrett’s Esophagus

    PubMed Central

    Sanchez, Carissa A.; Liu, Karen; Fong, Pui Yee; Li, Xiaohong; Cowan, David S.; Rabinovitch, Peter S.; Reid, Brian J.; Blount, Patricia L.

    2015-01-01

    Purpose Goblet cells may represent a potentially successful adaptive response to acid and bile by producing a thick mucous barrier that protects against cancer development in Barrett's esophagus (BE). The aim of this study was to determine the relationship between goblet cells (GC) and risk of progression to adenocarcinoma, and DNA content flow cytometric abnormalities, in BE patients. Experimental Design Baseline mucosal biopsies (N=2988) from 213 patients, 32 of whom developed cancer during the follow up period, enrolled in a prospective dynamic cohort of BE patients were scored in a blinded fashion, for the total number (#) of GC, mean # of GC/crypt (GC density), # of crypts with ≥ 1 GC, and the proportion of crypts with ≥1 GC, in both dysplastic and non-dysplastic epithelium separately. The relationship between these four GC parameters and DNA content flow cytometric abnormalities and adenocarcinoma outcome was compared, after adjustment for age, gender, and BE segment length. Results High GC parameters were inversely associated with DNA content flow cytometric abnormalities, such as aneuploidy, ploidy >2.7N, and an elevated 4N fraction > 6%, and with risk of adenocarcinoma. However, a Kaplan-Meier analysis showed that the total # of GC and the total # crypts with ≥1 GC were the only significant GC parameters (p<0.001 and 0.003, respectively). Conclusions The results of this study show, for the first time, an inverse relationship between high GC counts and flow cytometric abnormalities and risk of adenocarcinoma in BE. Further studies are needed to determine if GC depleted foci within esophageal columnar mucosa are more prone to neoplastic progression or whether loss of GC occurs secondary to underlying genetic abnormalities. PMID:26230607

  8. Plasma regimes in high power pulsed magnetron sputtering

    NASA Astrophysics Data System (ADS)

    de Los Arcos, Teresa

    2013-09-01

    High Power Pulsed Magnetron Sputtering (HPPMS) is a relatively recent variation of magnetron sputtering where high power is applied to the magnetron in short pulses. The result is the formation of dense transient plasmas with a high fraction of ionized species, ideally leading to better control of film growth through substrate bias. However, the broad range of experimental conditions accessible in pulsed discharges results in bewildering variations in current and voltage pulse shapes, pulse power densities, etc, which represent different discharge behaviors, making it difficult to identify relevant deposition conditions. The complexity of the plasma dynamics is evident. Within each pulse, plasma characteristics such as plasma composition, density, gas rarefaction, spatial distribution, degree of self-sputtering, etc. vary with time. A recent development has been the discovery that the plasma emission can self-organize into well-defined regions of high and low plasma emissivity above the racetrack (spokes), which rotate in the direction given by the E ×B drift and that significantly influence the transport mechanisms in HPPMS. One seemingly universal characteristic of HPPMS plasmas is the existence of well defined plasma regimes for different power ranges. These regimes are clearly differentiated in terms of plasma conductivity, plasma composition and spatial plasma self-organization. We will discuss the global characteristics of these regimes in terms of current-voltage characteristics, energy-resolved QMS and OES analysis, and fast imaging. In particular we will discuss how the reorganization of the plasma emission into spokes is associated only to specific regimes of high plasma conductivity. We will also briefly discuss the role of the target in shaping the characteristics of the HPPMS plasma, since sputtering is a surface-driven process. This work was supported by the Deutsche Forschungsgemeinschaft (DFG) within the framework of the SFB-TR87.

  9. Male rat infertility induction/spermatozoa and epididymal plasma abnormalities after oral administration of Kalanchoe gastonis bonnieri natural juice.

    PubMed

    de la Luz Miranda-Beltrán, María; Puebla-Pérez, Ana María; Guzmán-Sánchez, Arnoldo; Huacuja Ruiz, Luis

    2003-04-01

    Natural aqueous crude extracts (NACE) of several Crassulaceae family plants have been applied as a vaginal contraceptive by the populace. The aim of this work was to evaluate the inhibition of fertility in male Wistar rats and some physiological and biochemical changes in spermatozoa and epididymal plasma induced by NACE from Kalanchoe gastonis bonnieri (K. g. b.) (Crassulaceae). The NACE was obtained by mechanic pressure on grinding fresh plant leaves. Sublethal doses (150-300 mg/kg body weight) of NACE were orally administered to adult and fertile male rats daily for 30 days in a search for a contraceptive effect, and physiological and biochemical modifications on sperm cells and cauda epididymal plasma. The toxicity studies revealed that the lethal dose (LD(50)) calculated was 11 g/kg body weight. Sublethal doses induced 50%-100% fertility inhibition, with 100% recovery of fertility 30 days after stopping the treatment. The sperm motility, viability and spermatic density were also significantly decreased (p < 0.001). The outstanding biochemical change observed in the cauda epididymal plasma was a decrease of carnitine concentration. The NACE of K. gastonis contains one substance active on fertility by affecting spermatozoa motility, viability and sperm density with a significantly decreased carnitine and sialic acid (p < 0.001) in the caudal epididymal plasma. PMID:12722131

  10. High temperature UF6 and plasma research

    NASA Technical Reports Server (NTRS)

    Roman, W. C.

    1979-01-01

    Research currently under way on technology for uranium plasma core reactors is reviewed. A feeder system to provide a controlled and steady flow of UF6 at rates up to 5 g/sec and temperatures up to 500 K into rf plasma test chambers operating at pressures of up to 20 atm has been developed. Plasma emission and dye laser absorption measurements have been used to estimate the radial distribution of uranium atom number density within the plasma. X-ray absorption equipment and techniques have also been employed to measure the amount of uranium in the plasma, and dc plasma torch experiments have shown variations in plasma VUV emission with temperature. Analysis of residues deposited on various test-chamber components after plasma tests reveals traces of several uranium oxides, including UO2F2, and various exhaust duct configurations with flow augmentation are under investigation as means of preventing uranium deposition. Other areas of research include off- and on-line exhaust gas diagnostics, and a UF6/Ar injection, separation and recirculation system.

  11. Low Pressure High Density Plasma Development on a Small Helicon Plasma Experiment (HPX)*

    NASA Astrophysics Data System (ADS)

    James, R. W.; Allen, L. A.; Paolino, R. N.; Thayer, N.; Romano, B.; Stutzman, B. S.; Welicka, C.; Coast Guard Plasma Lab Team

    2011-10-01

    Small helicon plasmas have been employed in various capacities from industry to spacecraft propulsion. At the Coast Guard Academy Plasma Lab (CGAPL), a small Helicon Plasma Experiment (HPX) is being developed to utilize the reputed high densities (1013 cm-3 and higher) at low pressure (.01 T), in high temperature and density diagnostic development for future laboratory investigations. HPX is designed to operate at these high densities and pressure to create repeatedly stable Capacitively Coupled Plasma (CCP) and Inductively Coupled Plasma (ICP) plasmas induced by an RF frequency in the 10 to 70 MHz range. Progress on the development of the RF coupling system, and qualitative observations from the optical and electric diagnostics are to be reported.

  12. Transport Processes in High Temperature QCD Plasmas

    NASA Astrophysics Data System (ADS)

    Hong, Juhee

    The transport properties of high temperature QCD plasmas can be described by kinetic theory based on the Boltzmann equation. At a leading-log approximation, the Boltzmann equation is reformulated as a Fokker-Planck equation. First, we compute the spectral densities of Tµν and Jµ by perturbing the system with weak gravitational and electromagnetic fields. The spectral densities exhibit a smooth transition from free-streaming quasi-particles to hydrodynamics. This transition is analyzed with hydrodynamics and diffusion equation up to second order. We determine all of the first and second order transport coefficients which characterize the linear response in the hydrodynamic regime. Second, we simulate the wake of a heavy quark moving through the plasmas. At long distances, the energy density and flux distributions show sound waves and a diffusion wake. The kinetic theory calculations based on the Boltzmann equation at weak coupling are compared to the strong coupling results given by the AdS/CFT correspondence. By using the hard-thermal-loop effective theory, we determine the photon emission rate at next-to-leading order (NLO), i.e., at order g2mD /T. There are three mechanisms which contribute to the leading-order photon emission: (2 ↔ 2) elastic scatterings, (1 ↔ 2) collinear bremsstrahlung, and (1 ↔ 1) quark-photon conversion due to soft fermion exchange. At NLO, these three mechanisms are not completely independent. When the transverse momentum between quark and photon becomes soft, the Compton scattering with a soft gluon reduces to wide-angle bremsstrahlung. Similarly, bremsstrahlung reduces to the quark-photon conversion process when the photon carries most of the incoming momentum. Therefore, the rates should be matched to determine the wide-angle NLO correction. Collinear bremsstrahlung can be accounted for by solving an integral

  13. Spectroscopic diagnostics of high temperature plasmas

    SciTech Connect

    Moos, W.

    1990-01-01

    A three-year research program for the development of novel XUV spectroscopic diagnostics for magnetically confined fusion plasmas is proposed. The new diagnostic system will use layered synthetic microstructures (LSM) coated, flat and curved surfaces as dispersive elements in spectrometers and narrow band XUV filter arrays. In the framework of the proposed program we will develop impurity monitors for poloidal and toroidal resolved measurements on PBX-M and Alcator C-Mod, imaging XUV spectrometers for electron density and temperature fluctuation measurements in the hot plasma core in TEXT or other similar tokamaks and plasma imaging devices in soft x-ray light for impurity behavior studies during RF heating on Phaedrus T and carbon pellet ablation in Alcator C-Mod. Recent results related to use of multilayer in XUV plasma spectroscopy are presented. We also discuss the latest results reviewed to q{sub o} and local poloidal field measurements using Zeeman polarimetry.

  14. Meiotic abnormalities

    SciTech Connect

    1993-12-31

    Chapter 19, describes meiotic abnormalities. These include nondisjunction of autosomes and sex chromosomes, genetic and environmental causes of nondisjunction, misdivision of the centromere, chromosomally abnormal human sperm, male infertility, parental age, and origin of diploid gametes. 57 refs., 2 figs., 1 tab.

  15. Operation of the Proto-MPEX High Intensity Plasma Source

    NASA Astrophysics Data System (ADS)

    Caughman, J. B. O.; Goulding, R. H.; Biewer, T. M.; Bigelow, T. S.; Campbell, I. H.; Diem, S. J.; Martin, E. H.; Pesavento, P. V.; Rapp, J.; Ray, H. B.; Shaw, G. C.; Showers, M. A.; Luo, G.-N.

    2015-11-01

    The Prototype Materials Plasma Experiment (Proto-MPEX) is a linear high-intensity rf plasma source that combines a high-density helicon plasma generator with electron and ion heating sections. It is being used to study the physics of heating over-dense plasmas in a linear configuration. The helicon plasma is produced by coupling 13.56 MHz rf power at levels up to 100 kW. Microwaves at 28 GHz (~ 150 kW) are coupled to the electrons in the over-dense helicon plasma via Electron Bernstein Waves (EBW). Ion cyclotron heating (~ 30 kW) will be via a magnetic beach approach. Plasma diagnostics include Thomson Scattering and a retarding field energy analyzer near the target, while a microwave interferometer and double-Langmuir probes are used to determine plasma parameters elsewhere in the system. Filterscopes are being used to measure D-alpha emission and He line ratios at multiple locations, and IR cameras image the target plates to determine heat deposition. High plasma densities in the helicon region have been produced in He (>3x1019/m3) and D (>1.5x1019/m3) , and operation with on-axis magnetic field strength >1 T has been demonstrated. Details of the experimental results and future plans for studying plasma surface/RF antenna interactions will be presented. ORNL is managed by UT-Battelle, LLC, for the U.S. DOE under contract DE-AC-05-00OR22725.

  16. Electron density measurements in highly electronegative plasmas

    NASA Astrophysics Data System (ADS)

    Rafalskyi, D.; Lafleur, T.; Aanesland, A.

    2016-08-01

    In this paper we present experimental measurements of the electron density in very electronegative ‘ion–ion’ Ar–SF6 plasmas where previous investigations using Langmuir probes have observed electronegativities of up to 5000. The electron density is measured using a short matched dipole probe technique that provides a tolerance better than  ±2 · 1013 m‑3. The results demonstrate that the electron density in the low pressure plasma source (which contains a magnetic filter) can be reduced to around 2.7 · 1013 m‑3 with a corresponding plasma electronegativity of about 4000; close to that from fluid simulation predictions. The highest electronegativity, and lowest electron density, is achieved with a pure SF6 plasma, while adding only 6% SF6 to Ar allows the electronegativity to be increased from 0 to a few hundred with a corresponding decrease in the electron density by more than a thousand. The impedance probe based on a short matched dipole appears to be a practical diagnostic that can be used for independent measurements of the electron density in very electronegative plasmas, and opens up the possibility to further investigate and optimize electronegative plasma sources.

  17. Analysis of plasma channels in mm-scale plasmas formed by high intensity laser beams

    NASA Astrophysics Data System (ADS)

    Murakami, R.; Habara, H.; Ivancic, S.; Anderson, K.; Haberberger, D.; Iwawaki, T.; Sakagami, H.; Stoeckl, C.; Theobald, W.; Uematsu, Y.; Tanaka, K. A.

    2016-05-01

    A plasma channel created by a high intensity infrared laser beam was observed in a long scale-length plasma (L ∼ 240 μm) with the angular filter refractometry technique, which indicated a stable channel formation up to the critical density. We analyzed the observed plasma channel using a rigorous ray-tracing technique, which provides a deep understanding of the evolution of the channel formation.

  18. High plasma concentration of beta-D-glucan after administration of sizofiran for cervical cancer.

    PubMed

    Tokuyasu, Hirokazu; Takeda, Kenichi; Kawasaki, Yuji; Sakaguchi, Yasuto; Isowa, Noritaka; Shimizu, Eiji; Ueda, Yasuto

    2010-01-01

    A 69-year-old woman with a history of cervical cancer was admitted to our hospital for further investigation of abnormal shadows on her chest roentgenogram. Histologic examination of transbronchial lung biopsy specimens revealed epithelioid cell granuloma, and Mycobacterium intracellulare was detected in the bronchial lavage fluid. The plasma level of (1→3)-beta-d-glucan was very high, and this elevated level was attributed to administration of sizofiran for treatment of cervical cancer 18 years previously. Therefore, in patients with cervical cancer, it is important to confirm whether or not sizofiran has been administered before measuring (1→3)-beta-d-glucan levels. PMID:21042427

  19. Inversion of the western Pacific subtropical high dynamic model and analysis of dynamic characteristics for its abnormality

    NASA Astrophysics Data System (ADS)

    Hong, M.; Zhang, R.; Li, J. X.; Ge, J. J.; Liu, K. F.

    2013-02-01

    Based on time series data of 500 hPa potential field from NCEP/NCAR (National Center for Environmental Forecast of American/National Center for Atmospheric Research), a novel consideration of empirical orthogonal function (EOF) time-space separation and dynamic system reconstruction for time series is introduced. This method consists of two parts: first, the dynamical model inversion and model parameter optimization are carried out on the EOF time coefficient series using the genetic algorithm (GA), and, second, a nonlinear dynamic model representing the subtropical high (SH) activity and its abnormality is established. The SH activity and its abnormal mechanism is studied using the developed dynamical model. Results show that the configuration and diversification of the SH equilibriums have good correspondence with the actual short-medium term abnormal activity of the SH. Change of SH potential field brought by the combination of equilibriums is more complex than that by mutation, and their exhibition patterns are different. The mutation behavior from high-value to low-value equilibriums of the SH in summer corresponds with the southward drop of the SH in the observed weather process. The combination behavior of the two steady equilibriums corresponds with disappearance of the "double-ridge" phenomenon of the SH. Dynamical mechanisms of these phenomena are explained.

  20. High consumption of pulses is associated with lower risk of abnormal glucose metabolism in women in Mauritius

    PubMed Central

    Wennberg, M.; Söderberg, S.; Uusitalo, U.; Tuomilehto, J.; Shaw, J. E.; Zimmet, P. Z.; Kowlessur, S.; Pauvaday, V.; Magliano, D. J.

    2014-01-01

    Aims To investigate if consumption of pulses was associated with a reduced risk of developing abnormal glucose metabolism, increases in body weight and increases in waist circumference in a multi-ethnic cohort in Mauritius. Methods Population-based surveys were performed in Mauritius in 1992 and in 1998. Pulse consumption was estimated from a food frequency questionnaire in 1992 and outcomes were measured in 1998. At both time points, anthropometry was undertaken and an oral glucose tolerance test was performed. Results Mauritian women with the highest consumption of pulses (highest tertile) had a reduced risk of developing abnormal glucose metabolism [odds ratio 0.52; 95% CI 0.27, 0.99) compared with those with the lowest consumption, and also after multivariable adjustments. In women, a high consumption of pulses was associated with a smaller increase in BMI. Conclusions High consumption of pulses was associated with a reduced risk of abnormal glucose metabolism and a smaller increase in BMI in Mauritian women. Promotion of pulse consumption could be an important dietary intervention for the prevention of Type 2 diabetes and obesity in Mauritius and should be examined in other populations and in clinical trials. PMID:25346062

  1. Local thermodynamic equilibrium in rapidly heated high energy density plasmas

    SciTech Connect

    Aslanyan, V.; Tallents, G. J.

    2014-06-15

    Emission spectra and the dynamics of high energy density plasmas created by optical and Free Electron Lasers (FELs) depend on the populations of atomic levels. Calculations of plasma emission and ionization may be simplified by assuming Local Thermodynamic Equilibrium (LTE), where populations are given by the Saha-Boltzmann equation. LTE can be achieved at high densities when collisional processes are much more significant than radiative processes, but may not be valid if plasma conditions change rapidly. A collisional-radiative model has been used to calculate the times taken by carbon and iron plasmas to reach LTE at varying densities and heating rates. The effect of different energy deposition methods, as well as Ionization Potential Depression are explored. This work shows regimes in rapidly changing plasmas, such as those created by optical lasers and FELs, where the use of LTE is justified, because timescales for plasma changes are significantly longer than the times needed to achieve an LTE ionization balance.

  2. Local thermodynamic equilibrium in rapidly heated high energy density plasmas

    NASA Astrophysics Data System (ADS)

    Aslanyan, V.; Tallents, G. J.

    2014-06-01

    Emission spectra and the dynamics of high energy density plasmas created by optical and Free Electron Lasers (FELs) depend on the populations of atomic levels. Calculations of plasma emission and ionization may be simplified by assuming Local Thermodynamic Equilibrium (LTE), where populations are given by the Saha-Boltzmann equation. LTE can be achieved at high densities when collisional processes are much more significant than radiative processes, but may not be valid if plasma conditions change rapidly. A collisional-radiative model has been used to calculate the times taken by carbon and iron plasmas to reach LTE at varying densities and heating rates. The effect of different energy deposition methods, as well as Ionization Potential Depression are explored. This work shows regimes in rapidly changing plasmas, such as those created by optical lasers and FELs, where the use of LTE is justified, because timescales for plasma changes are significantly longer than the times needed to achieve an LTE ionization balance.

  3. Development of high energy pulsed plasma simulator for plasma-lithium trench experiment

    NASA Astrophysics Data System (ADS)

    Jung, Soonwook

    To simulate detrimental events in a tokamak and provide a test-stand for a liquid lithium infused trench (LiMIT) device, a pulsed plasma source utilizing a theta pinch in conjunction with a coaxial plasma accelerator has been developed. An overall objective of the project is to develop a compact device that can produce 100 MW/m2 to 1 GW/m2 of plasma heat flux (a typical heat flux level in a major fusion device) in ~ 100 mus (≤ 0.1 MJ/m2) for a liquid lithium plasma facing component research. The existing theta pinch device, DEVeX, was built and operated for study on lithium vapor shielding effect. However, a typical plasma energy of 3 - 4 kJ/m2 is too low to study an interaction of plasma and plasma facing components in fusion devices. No or little preionized plasma, ringing of magnetic field, collisions of high energy particles with background gas have been reported as the main issues. Therefore, DEVeX is reconfigured to mitigate these issues. The new device is mainly composed of a plasma gun for a preionization source, a theta pinch for heating, and guiding magnets for a better plasma transportation. Each component will be driven by capacitor banks and controlled by high voltage / current switches. Several diagnostics including triple Langmuir probe, calorimeter, optical emission measurement, Rogowski coil, flux loop, and fast ionization gauge are used to characterize the new device. A coaxial plasma gun is manufactured and installed in the previous theta pinch chamber. The plasma gun is equipped with 500 uF capacitor and a gas puff valve. The increase of the plasma velocity with the plasma gun capacitor voltage is consistent with the theoretical predictions and the velocity is located between the snowplow model and the weak - coupling limit. Plasma energies measured with the calorimeter ranges from 0.02 - 0.065 MJ/m2 and increases with the voltage at the capacitor bank. A cross-check between the plasma energy measured with the calorimeter and the triple probe

  4. High speed cine film studies of plasma behaviour and plasma surface interactions in tokamaks

    NASA Astrophysics Data System (ADS)

    Goodall, D. H. J.

    1982-12-01

    High speed cine photography is a useful diagnostic aid for studying plasma behaviour and plasma surface interactions. Several workers have filmed discharges in tokamaks including ASDEX, DITE, DIVA, ISX, JFT2, TFR and PLT. These films are discussed and examples given of the observed phenomena which include plasma limiter interactions, diverted discharges, disruptions, magnetic islands and moving glowing objects often known as 'UFOs'. Examples of plasma structures in ASDEX and DITE not previously published are also given. The paper also reports experiments in DITE to determine the origin of UFOs.

  5. Predicting hydrogen isotope inventory in plasma-facing components during normal and abnormal operations in fusion devices

    NASA Astrophysics Data System (ADS)

    Hu, Alice; Hassanein, Ahmed

    2015-10-01

    Hydrogen isotope behavior and inventory in plasma-facing components (PFCs) of fusion devices are key concerns for safe, reliable, and economical operation. To accurately estimate hydrogen isotope retention and recovery in tungsten (the current leading candidate as a PFC), we have developed a model that was recently benchmarked against isotope depth profile and retention level in a tungsten target under various conditions and compared with both experimental data and simulation results. In this research, we have extended the model to include details of transient events. Therefore, one can use this model to estimate hydrogen isotope retention behavior in tungsten and potential other PFC candidates during normal operational pulse, effects of edge-localized modes (ELMs), and a possible cleaning processes scenario.

  6. Abnormally Low or High Ankle-Brachial Index Is Associated with Proliferative Diabetic Retinopathy in Type 2 Diabetic Mellitus Patients

    PubMed Central

    Chen, Szu-Chia; Hsiao, Pi-Jung; Huang, Jiun-Chi; Lin, Kun-Der; Hsu, Wei-Hao; Lee, Yu-Li; Lee, Mei-Yueh; Chang, Jer-Ming; Shin, Shyi–Jang

    2015-01-01

    Although some studies have reported that low ankle-brachial index (ABI) is associated with diabetic retinopathy (DR) in diabetic patients, it remains controversial as to which stage of DR. The aim of this study is to assess whether peripheral artery disease (PAD), indicated by abnormally low or high ABI, is associated with different stages of DR in patients with type 2 diabetes mellitus (DM), and further evaluate the risk factors. A total of 2001 (858 men and 1143 women) patients with type 2 DM who underwent ABI measurement in an outpatient clinic were enrolled. PAD was defined as ABI < 0.9 or ≧ 1.3 in either leg. DR was classified as non-DR, nonproliferative DR and proliferative DR stages. The clinical data were analyzed and the risk factors for abnormal ABI were determined by multivariate logistic regression analysis. The prevalence of ABI < 0.9 or ≧ 1.3 was 3.0%. Multivariate forward logistic regression analysis identified proliferative DR (vs. non-DR) was associated with abnormal ABI (odds ratio, 1.718; 95% confidence interval, 1.152 to 2.562; p = 0.008), but nonproliferative DR was not. Furthermore, the presence of coronary artery disease, cerebrovascular disease, declining renal function and patients without diuretics use were associated with abnormal ABI in patients with proliferative DR. Our study in patients of type 2 DM demonstrated that PAD was associated with proliferative DR. We emphasize the recommendation of performing the ABI test in this population at risk. PMID:26230390

  7. Congenital Abnormalities

    MedlinePlus

    ... serious health problems (e.g. Down syndrome ). Single-Gene Abnormalities Sometimes the chromosomes are normal in number, ... blood flow to the fetus impair fetal growth. Alcohol consumption and certain drugs during pregnancy significantly increase ...

  8. Craniofacial Abnormalities

    MedlinePlus

    ... of the skull and face. Craniofacial abnormalities are birth defects of the face or head. Some, like cleft ... palate, are among the most common of all birth defects. Others are very rare. Most of them affect ...

  9. Walking abnormalities

    MedlinePlus

    ... include: Arthritis of the leg or foot joints Conversion disorder (a psychological disorder) Foot problems (such as a ... injuries. For an abnormal gait that occurs with conversion disorder, counseling and support from family members are strongly ...

  10. Chromosome Abnormalities

    MedlinePlus

    ... decade, newer techniques have been developed that allow scientists and doctors to screen for chromosomal abnormalities without using a microscope. These newer methods compare the patient's DNA to a normal DNA ...

  11. Nail abnormalities

    MedlinePlus

    Nail abnormalities are problems with the color, shape, texture, or thickness of the fingernails or toenails. ... Fungus or yeast cause changes in the color, texture, and shape of the nails. Bacterial infection may ...

  12. Dense Plasma Focus - From Alternative Fusion Source to Versatile High Energy Density Plasma Source for Plasma Nanotechnology

    NASA Astrophysics Data System (ADS)

    Rawat, R. S.

    2015-03-01

    The dense plasma focus (DPF), a coaxial plasma gun, utilizes pulsed high current electrical discharge to heat and compress the plasma to very high density and temperature with energy densities in the range of 1-10 × 1010 J/m3. The DPF device has always been in the company of several alternative magnetic fusion devices as it produces intense fusion neutrons. Several experiments conducted on many different DPF devices ranging over several order of storage energy have demonstrated that at higher storage energy the neutron production does not follow I4 scaling laws and deteriorate significantly raising concern about the device's capability and relevance for fusion energy. On the other hand, the high energy density pinch plasma in DPF device makes it a multiple radiation source of ions, electron, soft and hard x-rays, and neutrons, making it useful for several applications in many different fields such as lithography, radiography, imaging, activation analysis, radioisotopes production etc. Being a source of hot dense plasma, strong shockwave, intense energetic beams and radiation, etc, the DPF device, additionally, shows tremendous potential for applications in plasma nanoscience and plasma nanotechnology. In the present paper, the key features of plasma focus device are critically discussed to understand the novelties and opportunities that this device offers in processing and synthesis of nanophase materials using, both, the top-down and bottom-up approach. The results of recent key experimental investigations performed on (i) the processing and modification of bulk target substrates for phase change, surface reconstruction and nanostructurization, (ii) the nanostructurization of PLD grown magnetic thin films, and (iii) direct synthesis of nanostructured (nanowire, nanosheets and nanoflowers) materials using anode target material ablation, ablated plasma and background reactive gas based synthesis and purely gas phase synthesis of various different types of

  13. Ion Acoustic Waves, A High School Plasma Experiment

    NASA Astrophysics Data System (ADS)

    Buck, R.; Wise, J.; Gibson, N.; Buck, M.; Gekelman, W.; Wetzel, E.; Wetzel, C.; Moynihan, C.

    2001-10-01

    Over the last three the Los Angeles Physics Teachers Alliance Group (LAPTAG) has built a plasma device and designed experiments for high school students to learn about plasma properties and behavior. One of the first experiments performed by small student groups (two to three students at a time) is to create ion acoustic wave tonebursts in an Argon plasma, measure the wavelength and frequency of the wave and thereby calculate the velocity of the wave. A grid antenna immersed in the plasma, which is pulsed by a function generator, creates the waves. Measurements are made using a Langmuir probe and read out on a digital oscilloscope. From this information students calculate values such as the temperature of the plasma, the plasma density and percent ionization of the plasma. In order to do these experiments students must understand what plasma is, how plasma can be created using a helicon source, how to use an oscilloscope and many other aspects of the plasma chamber involved in the experiment. Other experiments are currently being done on the device and still others are being designed. For more information visit the LAPTAG website (http://coke.physics.ucla.edu/laptag).

  14. Multicentimeter long high density magnetic plasmas for optical guiding.

    PubMed

    Pollock, B B; Froula, D H; Tynan, G R; Divol, L; Price, D; Costa, R; Yepiz, F; Fulkerson, S; Mangini, F; Glenzer, S H

    2008-10-01

    We present a platform for producing long plasma channels suitable for guiding lasers over several centimeters by applying magnetic fields to limit the radial heat flux from a preforming laser beam. The resulting density gradient will be used as an optical plasma waveguide. The plasma conditions have been chosen to be consistent with the requirements for laser wakefield acceleration where multi-GeV electrons are predicted. A detailed description of the system used to produce the high (5 T) magnetic fields and initial results that show a 5 cm long plasma column are discussed. PMID:19044692

  15. A Plasma Lens for High Intensity Laser Focusing

    SciTech Connect

    Fang, F.; Clayton, C. E.; Marsh, K. A.; Joshi, C.; Lopes, N. C.; Ito, H.

    2006-11-27

    A plasma lens based on a short hydrogen-filled alumina capillary discharge is experimentally characterized. For a plasma length of about 5mm, the focal length, measured from the plasma entrance, was {approx} 11 to 8mm for on axis densities of {approx} 2.5 to 5 x 1018cm-3, respectively. The plasma temperature away from the walls of the 1/2mm diameter capillary was estimated to be {approx} 8eV indicating that the plasma is fully ionized. Such a lens should thus be suitable for focusing very high intensity pulses. Comparisons of the measured focusing strength to that predicted by a first-order fluid model [N. A. Bobrova, et al., Phys. Rev. E 65, 016407 (2002)] shows reasonable agreement given that some of the observed plasma parameters are not predicted by this model.

  16. Core plasma behavior during sawtooth activities in highly-elongated ohmic/ECH tokamak plasmas

    NASA Astrophysics Data System (ADS)

    Kim, Junghee; Lee, Seung Hun; Turri, G.; Weisen, H.; Choe, W.

    2008-11-01

    MHD instabilities arising from the combination of pressure and current profiles can deform the core plasma shape. The sawtoothing highly-elongated plasma shows various topological behaviors inside the q=1 surface. The irreversible topology-breaking of the core plasma occurs distinctively in highly-elongated ohmic plasma. On the contrary, the topological change does not occur in the ECH plasma under the same shaping factors because the increased conductivity results in the change of the current profile and thus affecting the Mercier criterion. In addition, the topology-breaking depends on the heating position. The ECH on the off-axis or the q=1 surface preserves the core topology during the crash. However, the intense on-axis ECH can change the core topology, which is reversible. The explanation for these activities is given by topological categorization and the stability analyses of the kink mode with pressure and current profiles.

  17. High-frequency Probing Diagnostic for Hall Current Plasma Thrusters

    SciTech Connect

    A.A. Litvak; Y. Raitses; N.J. Fisch

    2001-10-25

    High-frequency oscillations (1-100 MHz) in Hall thrusters have apparently eluded significant experimental scrutiny. A diagnostic setup, consisting of a single Langmuir probe, a special shielded probe connector-positioner, and an electronic impedance-matching circuit, was successfully built and calibrated. Through simultaneous high-frequency probing of the Hall thruster plasma at multiple locations, high-frequency plasma waves have been identified and characterized for various thruster operating conditions.

  18. High power Tesla driven miniature plasma opening switch

    NASA Astrophysics Data System (ADS)

    Kumar, Rajesh

    The plasma opening switch (POS) is used in pulsed power systems where a very fast opening and high current switch is required. Plasma is injected into the switch, which carries a large conduction current, before it opens in a process that lasts for a few nanosecond and transfers the current to a parallel-connected load at a much increased voltage and with a much shorter rise time. The conduction and opening times of the switch are dependent on plasma parameters such as the distribution, speed and species, all of which are determined by the plasma source. Most of the earlier reported work involves large dimension POSs and a correspondingly high input current (more than 100 kA) and uses carbon plasma. One main objective of the present research was to achieve a low input current (20 kA) and miniaturised POS by using hydrogen plasma rather than carbon plasma on account of its lower mass. A cable gun was selected for producing the plasma, since although this produces both hydrogen and carbon plasma these arise different times during its operation.. For the present application a Tesla transformer was used in preference to a Marx generator to produce an initial high voltage pulse for the system, on the basis of its simpler design and cost effectiveness. This transformer together with an associated water PFL (pulse forming line) and pressurised switch was capable of producing a load current in excess of 20 kA with a rise time of 53 ns, which was fed through the POS to the final load. Special diagnostics arrangements were necessary to measure the fast high current and voltage pulse a in nonintrusive way. Faraday cups and a high speed camera were used to measure the plasma parameters. The overall system built (i.e. including the POS) is capable of producing a 22 kA current with a rise time of 5 ns, and of generating a power of more than 10 GW..

  19. High performance deuterium-tritium plasmas in TFTR

    SciTech Connect

    Sabbagh, S.A.; Batha, S.H.; Bell, M.G.

    1995-03-01

    Plasmas composed of nominally equal concentrations of deuterium and tritium (DT) have been created in TFTR with the goals of producing significant levels of fusion power and of examining the effects of DT fusion alpha particles. Conditioning of the limiter by the injection of lithium pellets has led to an approximate doubling of the energy confinement time, {tau}{sub E}, in supershot plasmas at high plasma current (I{sub p} {le} 2.5 MA) and high heating power (P{sub b} {le} 33 MW). Operation with DT typically results in an additional 20% increase in {tau}{sub E}. In the high poloidal beta, advanced tokamak regime in TFTR, confinement enhancement H {triple_bond} {tau}{sub E}/{tau}{sub E ITER-89P} > 4 has been obtained in a limiter H-mode configuration at moderate plasma current I{sub p} = 0.85 {minus} 1.5 MA. By peaking the plasma current profile, {beta}{sub N dia} {triple_bond} 10{sup 8} < {beta}{sub t{perpendicular}} > aB{sub 0}/I{sub p} = 3 has been obtained in these plasmas, exceeding the {beta}{sub N} limit for TFTR plasmas with lower internal inductance, l{sub i}. Confinement of alpha particles appears to be classical and losses due to collective effects have not been observed. While small fluctuations in fusion product loss were observed during ELMs, no large loss was detected in DT plasmas.

  20. Understanding Plasmas with a High Degree of Correlation Through Modeling: From Rydberg and Fermionic Plasmas to Penning Plasmas

    NASA Astrophysics Data System (ADS)

    Christlieb, Andrew

    2015-09-01

    Ultra cold neutral plasmas have gained attention over the past 15 years as being a unique environment for studying moderately to strongly coupled neutral systems. The first ultra cold neutral plasmas were generated by ionizing a Bose Einstein condensate, generating a plasma with .1K ions and 2-4K electrons. These neutral plasmas have the unique property that the ratio of their potential energy to their kinetic energy, (Γ = PE / KE), can greatly exceed 1, leading to a strongly correlated system. The high degree of correlation means that everything from wave propagation through collision dynamics behaves quite differently from their counterpart in traditional neutral plasmas. Currently, a range of gases and different methods for cooling have been used to generate these plasmas from supersonic expansion, through penning trap configurations (reference Tom, Jake and Ed). These systems have time scales form picoseconds to milliseconds have a particle numbers from 105 to 109. These systems present a unique environment for studying the physics of correlation due to their low particle number and small size. We start by reviewing ultra cold plasmas and the current sate of the art in generating these correlated systems. Then we introduce the methods we will use for exploring these systems through direct simulation of Molecular Dynamics models; Momentum Dependent Potentials, Treecodes and Particle-Particle Particle-Mesh methods. We use these tools to look at two key areas of ultra cold plasmas; development of methods to generate a plasma with a Γ >> 1 and the impact of correlation of collisional relaxation. Our eventual goal is to use what we learn to develop models that can simulate correlation in large plasma systems that are outside of the scope of Molecular Dynamics models. In collaboration with Gautham Dharmuman, Mayur Jain, Michael Murillo and John Verboncoeur. This work it supposed by Air Force Office of Scientific Research.

  1. Investigation of a Plasma Ball using a High Speed Camera

    NASA Astrophysics Data System (ADS)

    Laird, James; Zweben, Stewart; Raitses, Yevgeny; Zwicker, Andrew; Kaganovich, Igor

    2008-11-01

    The physics of how a plasma ball works is not clearly understood. A plasma ball is a commercial ``toy'' in which a center electrode is charged to a high voltage and lightning-like discharges fill the ball with many plasma filaments. The ball uses high voltage applied on the center electrode (˜5 kV) which is covered with glass and capacitively coupled to the plasma filaments. This voltage oscillates at a frequency of ˜26 kHz. A Nebula plasma ball from Edmund Scientific was filmed with a Phantom v7.3 camera, which can operate at speeds up to 150,000 frames per second (fps) with a limit of >=2 μsec exposure per frame. At 100,000 fps the filaments were only visible for ˜5 μsec every ˜40 μsec. When the plasma ball is first switched on, the filaments formed only after ˜800 μsec and initially had a much larger diameter with more chaotic behavior than when the ball reached its final plasma filament state at ˜30 msec. Measurements are also being made of the final filament diameter, the speed of the filament propagation, and the effect of thermal gradients on the filament density. An attempt will be made to explain these results from plasma theory and movies of these filaments will be shown. Possible theoretical models include streamer-like formation, thermal condensation instability, and dielectric barrier discharge instability.

  2. X-ray emission from high temperature plasmas

    NASA Technical Reports Server (NTRS)

    Harries, W. L.

    1976-01-01

    The physical processes occurring in plasma focus devices were studied. These devices produce dense high temperature plasmas, which emit X rays of hundreds of KeV energy and one to ten billion neutrons per pulse. The processes in the devices seem related to solar flare phenomena, and would also be of interest for controlled thermonuclear fusion applications. The high intensity, short duration bursts of X rays and neutrons could also possibly be used for pumping nuclear lasers.

  3. Mapping high-latitude plasma convection with coherent HF radars

    NASA Technical Reports Server (NTRS)

    Ruohoniemi, J. M.; Greenwald, R. A.; Baker, K. B.; Villain, J.-P.; Hanuise, C.

    1989-01-01

    Several methods developed for mapping high-latitude plasma convection with a high-latitude HF radar are described, which utilize coherent backscatter from electron density irregularities at F-region altitudes to observe convective plasma motion. Several examples of two-dimensional convection-velocity maps are presented, showing instances of L-shell-aligned flow in the dusk sector, the reversal of convection near magnetic midnight, and counterstreaming in the dayside cleft.

  4. Mapping of Genetic Abnormalities of Primary Tumours from Metastatic CRC by High-Resolution SNP Arrays

    PubMed Central

    Sayagués, José María; Fontanillo, Celia; Abad, María del Mar; González-González, María; Sarasquete, María Eugenia; del Carmen Chillon, Maria; Garcia, Eva; Bengoechea, Oscar; Fonseca, Emilio; Gonzalez-Diaz, Marcos; De Las Rivas, Javier

    2010-01-01

    Background For years, the genetics of metastatic colorectal cancer (CRC) have been studied using a variety of techniques. However, most of the approaches employed so far have a relatively limited resolution which hampers detailed characterization of the common recurrent chromosomal breakpoints as well as the identification of small regions carrying genetic changes and the genes involved in them. Methodology/Principal Findings Here we applied 500K SNP arrays to map the most common chromosomal lesions present at diagnosis in a series of 23 primary tumours from sporadic CRC patients who had developed liver metastasis. Overall our results confirm that the genetic profile of metastatic CRC is defined by imbalanced gains of chromosomes 7, 8q, 11q, 13q, 20q and X together with losses of the 1p, 8p, 17p and 18q chromosome regions. In addition, SNP-array studies allowed the identification of small (<1.3 Mb) and extensive/large (>1.5 Mb) altered DNA sequences, many of which contain cancer genes known to be involved in CRC and the metastatic process. Detailed characterization of the breakpoint regions for the altered chromosomes showed four recurrent breakpoints at chromosomes 1p12, 8p12, 17p11.2 and 20p12.1; interestingly, the most frequently observed recurrent chromosomal breakpoint was localized at 17p11.2 and systematically targeted the FAM27L gene, whose role in CRC deserves further investigations. Conclusions/Significance In summary, in the present study we provide a detailed map of the genetic abnormalities of primary tumours from metastatic CRC patients, which confirm and extend on previous observations as regards the identification of genes potentially involved in development of CRC and the metastatic process. PMID:21060790

  5. High quality topic extraction from business news explains abnormal financial market volatility.

    PubMed

    Hisano, Ryohei; Sornette, Didier; Mizuno, Takayuki; Ohnishi, Takaaki; Watanabe, Tsutomu

    2013-01-01

    Understanding the mutual relationships between information flows and social activity in society today is one of the cornerstones of the social sciences. In financial economics, the key issue in this regard is understanding and quantifying how news of all possible types (geopolitical, environmental, social, financial, economic, etc.) affects trading and the pricing of firms in organized stock markets. In this article, we seek to address this issue by performing an analysis of more than 24 million news records provided by Thompson Reuters and of their relationship with trading activity for 206 major stocks in the S&P US stock index. We show that the whole landscape of news that affects stock price movements can be automatically summarized via simple regularized regressions between trading activity and news information pieces decomposed, with the help of simple topic modeling techniques, into their "thematic" features. Using these methods, we are able to estimate and quantify the impacts of news on trading. We introduce network-based visualization techniques to represent the whole landscape of news information associated with a basket of stocks. The examination of the words that are representative of the topic distributions confirms that our method is able to extract the significant pieces of information influencing the stock market. Our results show that one of the most puzzling stylized facts in financial economies, namely that at certain times trading volumes appear to be "abnormally large," can be partially explained by the flow of news. In this sense, our results prove that there is no "excess trading," when restricting to times when news is genuinely novel and provides relevant financial information. PMID:23762258

  6. High Quality Topic Extraction from Business News Explains Abnormal Financial Market Volatility

    PubMed Central

    Hisano, Ryohei; Sornette, Didier; Mizuno, Takayuki; Ohnishi, Takaaki; Watanabe, Tsutomu

    2013-01-01

    Understanding the mutual relationships between information flows and social activity in society today is one of the cornerstones of the social sciences. In financial economics, the key issue in this regard is understanding and quantifying how news of all possible types (geopolitical, environmental, social, financial, economic, etc.) affects trading and the pricing of firms in organized stock markets. In this article, we seek to address this issue by performing an analysis of more than 24 million news records provided by Thompson Reuters and of their relationship with trading activity for 206 major stocks in the S&P US stock index. We show that the whole landscape of news that affects stock price movements can be automatically summarized via simple regularized regressions between trading activity and news information pieces decomposed, with the help of simple topic modeling techniques, into their “thematic” features. Using these methods, we are able to estimate and quantify the impacts of news on trading. We introduce network-based visualization techniques to represent the whole landscape of news information associated with a basket of stocks. The examination of the words that are representative of the topic distributions confirms that our method is able to extract the significant pieces of information influencing the stock market. Our results show that one of the most puzzling stylized facts in financial economies, namely that at certain times trading volumes appear to be “abnormally large,” can be partially explained by the flow of news. In this sense, our results prove that there is no “excess trading,” when restricting to times when news is genuinely novel and provides relevant financial information. PMID:23762258

  7. Maternal high-fat hypercaloric diet during pregnancy results in persistent metabolic and respiratory abnormalities in offspring

    PubMed Central

    Griffiths, Pamela S.; Walton, Cheryl; Samsell, Lennie; Perez, Miriam K.; Piedimonte, Giovanni

    2016-01-01

    Background: We have shown in a previous population-based study significant correlation between childhood asthma and early abnormalities of lipid and glucose metabolism. This study's specific aim was to determine whether maternal nutrition in pregnancy affects postnatal metabolic and respiratory outcomes in the offspring. Methods: On gestation day 1, dams were switched from standard chow to either high-fat hypercaloric diet or control diet. Terminal experiments were performed on newborn and weanling offspring of dams fed the study diet during gestation and lactation, and on adult offspring maintained on the same diet as their mother. Results: Pups born from high-fat hypercaloric diet (HFD) dams developed metabolic abnormalities persistent throughout development. Cytokine expression analysis of lung tissues from newborns born to HFD dams revealed a strong proinflammatory pattern. Gene expression of neurotrophic factors and receptors was upregulated in lungs of weanlings born to HFD dams, and this was associated to higher respiratory system resistance and lower compliance at baseline, as well as hyperreactivity to aerosolized methacholine. Furthermore, HFD dams delivered pups prone to develop more severe disease after respiratory syncytial virus (RSV) infection. Conclusion: Maternal nutrition in pregnancy is a critical determinant of airway inflammation and hyperreactivity in offspring and also increases risk for bronchiolitis independent from prepregnancy nutrition. PMID:26539661

  8. Note: Zeeman splitting measurements in a high-temperature plasma

    SciTech Connect

    Golingo, R. P.; Shumlak, U.; Den Hartog, D. J.

    2010-12-15

    The Zeeman effect has been used for measurement of magnetic fields in low-temperature plasma, but the diagnostic technique is difficult to implement in a high-temperature plasma. This paper describes new instrumentation and methodology for simultaneous measurement of the entire Doppler-broadened left and right circularly polarized Zeeman spectra in high-temperature plasmas. Measurements are made using spectra emitted parallel to the magnetic field by carbon impurities in high-temperature plasma. The Doppler-broadened width is much larger than the magnitude of the Zeeman splitting, thus simultaneous recording of the two circularly polarized Zeeman line profiles is key to accurate measurement of the magnetic field in the ZaP Z-pinch plasma device. Spectral data are collected along multiple chords on both sides of the symmetry axis of the plasma. This enables determination of the location of the current axis of the Z-pinch and of lower-bound estimates of the local magnetic field at specific radial locations in the plasma.

  9. Design of a High-Throughput Plasma-Processing System

    SciTech Connect

    Darkazalli, Ghazi; Matthei, Keith; Ruby, Douglas S.

    1999-07-20

    Sandia National Laboratories has demonstrated significant performance gains in crystalline silicon solar cell technology through the use of plasma-processing for the deposition of silicon nitride by Plasma Enhanced Chemical Vapor Deposition (PECVD), plasma-hydrogenation of the nitride layer, and reactive-ion etching of the silicon surface prior to the deposition to decrease the reflectivity of the surface. One of the major problems of implementing plasma processing into a cell production line is the batch configuration and/or low throughput of the systems currently available. This report describes the concept of a new in-line plasma processing system that could meet the industrial requirements for a high-throughput and cost effective solution for mass production of solar cells.

  10. Spherically symmetric high-velocity plasma expansions into background gases

    NASA Technical Reports Server (NTRS)

    Tan, T.-H.; Borovsky, J. E.

    1986-01-01

    Spherically symmetric plasmas with high expansion velocities have been produced by irradiating targets with eight beams from the Helios CO2 laser in the presence of gases at various pressures. Attention was given to the properties of the target-emitted ions in order to obtain information about the ion-acceleration mechanisms in plasma expansions. Photoionization of the ambient gases by the soft X-ray emission from the laser-irradiated targets produced background plasmas, permitting plasma counterstreaming experiments to be performed in spherical geometry. Successful laser-target coupling in the presence of back-ground gases is obtained; modification of the ion acceleration in accordance with isothermal-expansion models is observed; and an absence of collective coupling between collisionless counterstreaming plasmas is found.

  11. Physics of High Performance Dueterium-Tritium Plasmas in TFTR

    SciTech Connect

    McGuire, K. M.; White, R.; Wieland, R. M.; Williams, M.; Wilson, J. R.; Wong, K. L.; Wurden, G. A.; Batha, S.; Lamarche, P.; LeBlanc, B.; Levinton, F. M.; Beer, M.; Bell, M. G.; Bell, R. E.; Belov, A.; Fredrickson, E. D.; Fu, G. Y.; Furth, H. P.; Gorelenkov, N. N.; Krasilnikov, A. V.; Meade, D. M.; Medley, S. S.; Mika, R.; Mikkelsen, D. R.; Mirnov, S. V.; Schilling, G.; Schivell, J.; Schmidt, G. L.; Scott, S. D.; Semenov, I.; Berk, H.; Bernabei, S.; Bitter, M.; Breizman, B.; Dorland, W.; Phillips, P.; Bretz, N. L.; Budny, R.; Bush, C.E.; Grek, B.; Grisham, L. R.; Hammett, G. W.; Herrmann, H. W.; Herrmann, M.; Hill, K. W.; Hogan, G. R.; Hosea, J. C.

    1996-01-01

    During the past two years, deuterium-tritium (D-T) plasmas in the Tokamak Fusion Test Reactor (TFTR) have been used to study fusion power production,isotope effects associated with tritium fueling, and alpha-particle physics in several operational regimes. The peak fusion power has been increased to 10.7 MW in the supershot mode through the use of increased plasma current and toroidal magnetic field and extensive lithium wall conditioning. The high-internal-inductance (high -li) regime in TFTR has been extended in plasma current and has achieved 8.7 MW of fusion power. Studies of the effects of tritium on confinement have now been carried out in ohmic, NBI- and ICRF-heated L-mode and reversed-shear plasmas. In general, there is an enhancement in confinement time in D-T plasmas which is most pronounced in supershot and high-li discharges, weaker in L-mode plasmas with NBI and ICRF heating and smaller still in ohmic plasmas. In reversed-shear discharges with sufficient deuterium-NBI heating power, internal transport barriers have been observed to form, leading to enhanced confinement. Large decreases in the ion heat conductivity and particle transport are inferred within the transport barrier.It appears that higher heating power is required to trigger the formation of a transport barrier with D-T NBI and the isotope effect on energy confinement is nearly absent in these enhanced reverse-shear plasmas. Many alpha-particle physics issues have been studied in the various operating regimes including confinement of the alpha particles, their redistribution by sawteeth, and their loss due to MHD instabilities with low toroidal mode numbers. In weak-shear plasmas, alpha-particle destabilization of a toroidal Alfven eigenmode has been observed.

  12. Drift Resonance in High Density Nonneutral Plasmas

    NASA Astrophysics Data System (ADS)

    Kaup, D. J.

    2005-10-01

    Theoretical studies of the operation of crossed-field electron vacuum devices, such as magnetrons and crossed-field amplifiers (CFA), have usually centered on their initial growth, taking this as an indication of their operating modes. In such an analysis, one solves the equations for the density profile and other features of these devices. However what one actually obtains are only the conditions for the initial operation of the device. Eventually the rf fields will saturate, at which time, an operating device will settle into a stationary operating regime, called the ``saturation stage,'' which is where the device simply delivers rf power. Here there is a different set of physical interactions occuring. The amplitudes have saturated and the ponderomotive forces and nonlinear diffusion of the initiation stage have vanished. In this saturation stage, we now find three new rf modes appearing, in addition to the two modes of the initiation stage. These three new modes have very fast oscillations in the vertical direction: one fast mode corresponds to a plasma drift wave, while the other two fast modes are cyclotron-like modes. In this presentation, we will describe how the fast plasma drift wave interacts with the slow modes at the diocotron resonance. In particular, we will determine the conversion coefficients for the crossing of the drift mode with the slow modes at the diocotron resonance.

  13. Progress in Development of Low Pressure High Density Plasmas on a Small Helicon Plasma Experiment (HPX)

    NASA Astrophysics Data System (ADS)

    James, Royce; Lopez, M.; Nolan, S.; Page, E. L.; Schlank, C.; Sherman, J.; Stutzman, B. S.; Zuniga, J.

    2012-10-01

    At the Coast Guard Academy Plasma Lab (CGAPL), a small Helicon Plasma Experiment (HPX) is being developed to utilize the reputed high densities (10^13 cm-3 and higher) at low pressure (.01 T) [1], for eventual high temperature and density diagnostic development in future laboratory investigations. HPX is designed to create repeatedly stable plasmas induced by an RF frequency in the 10 to 70 MHz range and employs an electromagnet to provide the external energy in the plasma's magnetic field to transition from the H-Mode to the Helicon Mode. An acceleration coil, currently under construction, will place the plasma in the vacuum chamber for optical and particle probing. With the initial construction phase complete and first plasmas attained, HPX is constructing triple and mach particle probes, magnetic probes, and a single point 300 W Thompson Scattering system backed by a 32-channel DAQ system capable 12 bits of sampling precision at 2 MS/s for plasma property investigations. Progress on the development of the RF coupling system, magnetic coils, and qualitative observations from the optical and electric diagnostics are to be reported. [4pt] [1] K. Toki, et al., Thin Solid Films 506-507 (2005).

  14. High temperature UF6 RF plasma experiments applicable to uranium plasma core reactors

    NASA Technical Reports Server (NTRS)

    Roman, W. C.

    1979-01-01

    An investigation was conducted using a 1.2 MW RF induction heater facility to aid in developing the technology necessary for designing a self critical fissioning uranium plasma core reactor. Pure, high temperature uranium hexafluoride (UF6) was injected into an argon fluid mechanically confined, steady state, RF heated plasma while employing different exhaust systems and diagnostic techniques to simulate and investigate some potential characteristics of uranium plasma core nuclear reactors. The development of techniques and equipment for fluid mechanical confinement of RF heated uranium plasmas with a high density of uranium vapor within the plasma, while simultaneously minimizing deposition of uranium and uranium compounds on the test chamber peripheral wall, endwall surfaces, and primary exhaust ducts, is discussed. The material tests and handling techniques suitable for use with high temperature, high pressure, gaseous UF6 are described and the development of complementary diagnostic instrumentation and measurement techniques to characterize the uranium plasma, effluent exhaust gases, and residue deposited on the test chamber and exhaust system components is reported.

  15. EUROarray human papillomavirus (HPV) assay is highly concordant with other commercial assays for detection of high-risk HPV genotypes in women with high grade cervical abnormalities.

    PubMed

    Cornall, A M; Poljak, M; Garland, S M; Phillips, S; Machalek, D A; Tan, J H; Quinn, M A; Tabrizi, S N

    2016-06-01

    The purpose of this study was to evaluate the performance of the EUROIMMUN EUROArray HPV genotyping assay against the Roche Cobas 4800, Roche HPV Amplicor, Roche Linear Array and Qiagen Hybrid Capture 2 assays in the detection of high-risk HPV (HR-HPV) from liquid based cervical cytology samples collected from women undergoing follow-up for abnormal cervical cytology results. Cervical specimens from 404 women undergoing management of high-grade cytological abnormality were evaluated by EUROarray HPV for detection of HR-HPV genotypes and prediction of histologically-confirmed cervical intraepithelial neoplasia grade 2 or higher (≥CIN2). The results were compared to Hybrid Capture 2, Cobas 4800 HPV, Amplicor and Linear Array HPV. Positivity for 14 HR-HPV types was 80.0 % for EUROarray (95 % CI; 75.7-83.8 %). Agreement (κ, 95 % CI) between the EUROarray and other HPV tests for detection of HR-HPV was good to very good [Hybrid Capture κ = 0.62 (0.54-0.71); Cobas κ = 0.81 (0.74-0.88); Amplicor κ = 0.68 (0.60-0.77); Linear Array κ = 0.77 (0.70-0.85)]. For detection of HR-HPV, agreement with EUROarray was 87.90 % (Hybrid Capture), 93.58 % (Cobas), 92.84 % (Amplicor) and 92.59 % (Linear Array). Detection of HR-HPV was not significantly different between EUROarray and any other test (p < 0.001). EUROarray was concordant with other assays evaluated for detection of high-risk HPV and showed sensitivity and specificity for detection of ≥ CIN2 of 86 % and 71 %, respectively. PMID:27048314

  16. Magnetic fields, plasma densities, and plasma beta parameters estimated from high-frequency zebra fine structures

    NASA Astrophysics Data System (ADS)

    Karlický, M.; Jiricka, K.

    2002-10-01

    Using the recent model of the radio zebra fine structures (Ledenev et al. 2001) the magnetic fields, plasma densities, and plasma beta parameters are estimated from high-frequency zebra fine structures. It was found that in the flare radio source of high-frequency (1-2 GHz) zebras the densities and magnetic fields vary in the intervals of (1-4)×1010 cm-3 and 40-230 G, respectively. Assuming then the flare temperature as about of 107K, the plasma beta parameters in the zebra radio sources are in the 0.05-0.81 interval. Thus the plasma pressure effects in such radio sources, especially in those with many zebra lines, are not negligible.

  17. Evolution of Abnormal Plasma Glucagon Responses to Mixed-Meal Feedings in Youth With Type 1 Diabetes During the First 2 Years After Diagnosis

    PubMed Central

    Sherr, Jennifer; Tsalikian, Eva; Fox, Larry; Buckingham, Bruce; Weinzimer, Stuart; Tamborlane, William V.; White, Neil H.; Arbelaez, Ana Maria; Kollman, Craig; Ruedy, Katrina J.; Cheng, Peiyao; Beck, Roy W.

    2014-01-01

    OBJECTIVE To examine the evolution of the dysregulated glucagon responses to mixed-meal tolerance tests (MMTTs) in youth with recent-onset type 1 diabetes (T1D). RESEARCH DESIGN AND METHODS MMTTs were performed in 25 youth (9–18 years of age) with 1.5–12 months disease duration (year 1); 22 subjects were restudied 1 year later (year 2). Twenty nondiabetic (ND) control children were also studied. RESULTS In T1D children, MMTT-stimulated increases in glucagon were significantly greater than that in ND children (median increments: year 1, 21 pg/mL [16–30]; year 2, 25 pg/mL [16–30]; ND, 9 pg/mL [5–16]; P = 0.001 and P < 0.001, respectively). CONCLUSIONS In comparison with ND control children, exaggerated plasma glucagon responses to mixed-meal feedings are observed in youth with T1D within the first 2 years of diagnosis. Further studies to determine whether suppression of these abnormal responses may help to improve glycemic control are warranted. PMID:24696460

  18. Topics in high voltage pulsed power plasma devices and applications

    NASA Astrophysics Data System (ADS)

    Chen, Hao

    Pulsed power technology is one of the tools that is used by scientists and engineers nowadays to produce gas plasmas. The transient ultra high power is able to provide a huge pulse of energy which is sometimes greater than the ionization energy of the gas, and therefore separates the ions and electrons to form the plasma. Sometimes, the pulsed power components themselves are plasma devices. For example, the gas type switches can "turn on" the circuit by creating the plasma channel between the switch electrodes. Mini Back Lighted Thyratron, or as we call it, mini-BLT, is one of these gas type plasma switches. The development of the reduced size and weight "mini-BLT" is presented in this dissertation. Based on the operation characteristics testing of the mini-BLT, suggestions of optimizing the design of the switch are proposed. All the factors such as the geometry of the hollow electrodes and switch housing, the gas condition, the optical triggering source, etc. are necessary to consider when we design and operate the mini-BLT. By reducing the diameter of the cylindrical gas path between the electrodes in the BLT, a novel high density plasma source is developed, producing the plasma in the "squeezed" capillary. The pulsed power generator, of course, is inevitably used to provide the ionization energy for hydrogen gas sealed in the capillary. Plasma diagnostics are necessarily analyzed and presented in detail to properly complete and understand the capillary plasma. This high density plasma source (1019 cm-3) has the potential applications in the plasma wakefield accelerator. The resonant oscillation behavior of the particles in plasmas allows for dynamically generated accelerating electric fields that have orders of magnitude larger than those available in the conventional RF accelerators. Finally, the solid state switches are introduced as a comparison to the gas type switch. Pulsed power circuit topologies such as the Marx Bank, magnetic pulse compression and diode

  19. Physics of high performance deuterium-tritium plasmas in TFTR

    SciTech Connect

    McGuire, K.M.; Barnes, C.W.; Batha, S.

    1996-11-01

    During the past two years, deuterium-tritium (D-T) plasmas in the Tokamak Fusion Test Reactor (TFTR) have been used to study fusion power production, isotope effects associated with tritium fueling, and alpha-particle physics in several operational regimes. The peak fusion power has been increased to 10.7 MW in the supershot mode through the use of increased plasma current and toroidal magnetic field and extensive lithium wall conditioning. The high-internal-inductance (high-I{sub i}) regime in TFTR has been extended in plasma current and has achieved 8.7 MW of fusion power. Studies of the effects of tritium on confinement have now been carried out in ohmic, NBI- and ICRF- heated L-mode and reversed-shear plasmas. In general, there is an enhancement in confinement time in D-T plasmas which is most pronounced in supershot and high-I{sub i} discharges, weaker in L-mode plasmas with NBI and ICRF heating and smaller still in ohmic plasmas. In reversed-shear discharges with sufficient deuterium-NBI heating power, internal transport barriers have been observed to form, leading to enhanced confinement. Large decreases in the ion heat conductivity and particle transport are inferred within the transport barrier. It appears that higher heating power is required to trigger the formation of a transport barrier with D-T NBI and the isotope effect on energy confinement is nearly absent in these enhanced reverse-shear plasmas. Many alpha-particle physics issues have been studied in the various operating regimes including confinement of the alpha particles, their redistribution by sawteeth, and their loss due to MHD instabilities with low toroidal mode numbers. In weak-shear plasmas, alpha-particle destabilization of a toroidal Alfven eigenmode has been observed.

  20. Aluminium plasma production at high laser intensity

    SciTech Connect

    Torrisi, L.; Cutroneo, M.

    2014-02-28

    Thick and thin films of Al targets were irradiated in vacuum with iodine laser at 1315 nm wavelength, 300 ps pulse duration at a maximum intensity of about 10{sup 16} W/cm{sup 2} by varying the pulse energy and focal position. The laser-generated plasma was monitored in forward and backward directions by using ion collectors, SiC detectors, Thomson parabola spectrometer, and X-ray streak camera. Ion emission shows maximum proton energy of about 4 MeV in self-focusing conditions and a maximum Al ion energy of about 50 MeV. An evaluation of the electric field driving ions in conditions of target normal sheath acceleration is given.

  1. Interaction of High Intensity Electromagnetic Waves with Plasmas

    SciTech Connect

    G. Shvets

    2008-10-03

    The focus of our work during the duration of this grant was on the following areas: (a) the fundamental plasma physics of intense laser-plasma interactions, including the nonlinear excitation of plasma waves for accelerator applications, as well as the recently discovered by us phenomenon of the relativistic bi-stability of relativistic plasma waves driven by a laser beatwave; (b) interaction of high power microwave beams with magnetized plasma, including some of the recently discovered by us phenomena such as the Undulator Induced Transparency (UIT) as well as the new approaches to dynamic manipulation of microwave pulses; (c) investigations of the multi-color laser pulse interactions in the plasma, including the recently discovered by us phenomenon of Electromagnetic Cascading (EC) and the effect of the EC of three-dimensional dynamics of laser pulses (enhanced/suppressed selffocusing etc.); (d) interaction of high-current electron beams with the ambient plasma in the context of Fast Ignitor (FI) physics, with the emphasis on the nonlinear dynamics of the Weibel instability and beam filamentation.

  2. Frontiers in plasma science: a high energy density perspective

    NASA Astrophysics Data System (ADS)

    Remington, Bruce

    2015-11-01

    The potential for ground-breaking research in plasma physics in high energy density (HED) regimes is compelling. The combination of HED facilities around the world spanning microjoules to megajoules, with time scales ranging from femtoseconds to microseconds enables new regimes of plasma science to be experimentally probed. The ability to shock and ramp compress samples and simultaneously probe them allows dense, strongly coupled, Fermi degenerate plasmas relevant to planetary interiors to be studied. Shock driven hydrodynamic instabilities evolving into turbulent flows relevant to the dynamics of exploding stars are being probed. The physics and dynamics of magnetized plasmas relevant to astrophysics and inertial confinement fusion are also starting to be studied. High temperature, high velocity interacting flows are being probed for evidence of astrophysical collisionless shock formation. Turbulent, high magnetic Reynolds number flows are being experimentally generated to look for evidence of the turbulent magnetic dynamo effect. And new results from thermonuclear reactions in dense hot plasmas relevant to stellar interiors are starting to emerge. A selection of examples providing a compelling vision for frontier plasma science in the coming decade will be presented. This work performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344.

  3. High-order harmonics from laser-irradiated plasma surfaces

    SciTech Connect

    Teubner, U.; Gibbon, P.

    2009-04-15

    The investigation of high-order harmonic generation (HHG) of femtosecond laser pulses by means of laser-produced plasmas is surveyed. This kind of harmonic generation is an alternative to the HHG in gases and shows significantly higher conversion efficiency. Furthermore, with plasma targets there is no limitation on applicable laser intensity and thus the generated harmonics can be much more intense. In principle, harmonic light may also be generated at relativistic laser intensity, in which case their harmonic intensities may even exceed that of the focused laser pulse by many orders of magnitude. This phenomenon presents new opportunities for applications such as nonlinear optics in the extreme ultraviolet region, photoelectron spectroscopy, and opacity measurements of high-density matter with high temporal and spatial resolution. On the other hand, HHG is strongly influenced by the laser-plasma interaction itself. In particular, recent results show a strong correlation with high-energy electrons generated during the interaction process. The harmonics are a promising tool for obtaining information not only on plasma parameters such as the local electron density, but also on the presence of large electric and magnetic fields, plasma waves, and the (electron) transport inside the target. This paper reviews the theoretical and experimental progress on HHG via laser-plasma interactions and discusses the prospects for applying HHG as a short-wavelength, coherent optical tool.

  4. Acute plasma volume change with high-intensity sprint exercise.

    PubMed

    Bloomer, Richard J; Farney, Tyler M

    2013-10-01

    When exercise is of long duration or of moderate to high intensity, a decrease in plasma volume can be observed. This has been noted for both aerobic and resistance exercise, but few data are available with regard to high-intensity sprint exercise. We measured plasma volume before and after 3 different bouts of acute exercise, of varying intensity, and/or duration. On different days, men (n = 12; 21-35 years) performed aerobic cycle exercise (60 minutes at 70% heart rate reserve) and 2 different bouts of cycle sprints (five 60-second sprints at 100% maximum wattage obtained during graded exercise testing (GXT) and ten 15-second sprints at 200% maximum wattage obtained during GXT). Blood was collected before and 0, 30, and 60 minutes postexercise and analyzed for hematocrit and hemoglobin and plasma volume was calculated. Plasma volume decreased significantly for all exercise bouts (p < 0.05), with the greatest decrease noted 0 minute postexercise for both sprint bouts (∼19%) compared with aerobic exercise bouts (∼11%). By 30 minutes postexercise, plasma volume approached pre-exercise values. We conclude that acute bouts of exercise, in particular high-intensity sprint exercise, significantly decrease plasma volume during the immediate postexercise period. It is unknown what, if any negative implications these transient changes may have on exercise performance. Strength and conditioning professionals may aim to rehydrate athletes appropriately after high-intensity exercise bouts. PMID:23302756

  5. Magnetospheric plasma studies using data from the Dynamics high and low altitude plasma instruments. Technical report

    SciTech Connect

    Barfield, J.N.

    1983-05-15

    Plasma data from the High and Low Altitude Plasma Instruments aboard the Dynamics 1 and 2 (DE-1 and DE-2) satellites have been analyzed to investigate high latitude plasma characteristics. DE-1 hot plasma observations in the mid-altitude polar cusp have shown evidence of a significant velocity filtering phenomenon which is consistent with a latitudinally narrow region of plasma injection located at a geocentric distance of about 8 earth radii (RE). This velocity filtering effect allows the measurement of much smaller flow velocities (about km/s) than have heretofore been possible with plasma measurements. Observations at altitudes of 2-3 RE indicate two distinct types of counterstreaming electron events. The type 1 event is characterized by two Maxwellian distribution functions, an isotropic high-temperature component and a field-aligned low temperature component. Type 1 events appear to involve wave-particle interactions while type 2 events imply direct acceleration by oppositely-directed electric fields pointing toward the satellite along magnetic field lines. The data indicate that cold ionospheric electrons, which carry the downward region-1 Birkeland currents on the morning side, are accelerated upward by potential drops of tens of eV at altitudes of several thousand kilometers. This acceleration process allows spacecraft above those altitudes to measure routinely the charge carriers of both downward and upward current systems.

  6. High Energy-Density Plasma Production from Plasma-Filled Rod-Pinch Diodes

    NASA Astrophysics Data System (ADS)

    Schumer, J. W.; Weber, B. V.; Mosher, D.; Apruzese, J. P.

    2008-04-01

    The Plasma-Filled Rod-Pinch diode (PFRP) concentrates a 100-ns, 500-kA, >MeV electron-beam onto the tip of a tapered tungsten rod, generating a High Energy Density Plasma (HEDP). The HEDP (warm dense plasma) is created by deposition of a high-power-density (40 TW/cm^2) electron-beam into solid-density tungsten. The diode current and voltage has been shown to be controllably modified between 260 kA and 1.8 MV to 770 kA and 0.45 MV by increasing the initial plasma-fill density. At the time of peak energy density, analytic estimates using a 0-d self-similar MHD model predict a solid-density (20 g/cm^3) tungsten plasma with 25 eV temperature, 16 Mbar pressure, and 2.4 MJ/cm^3 thermal energy density prior to rapid plasma expansion (after about 10 ns). Temperature and ionization state increase after this time as the rod-tip rapidly expands. This PFRP approach may have advantages for HEDP research. Various applications include high-fluence flash radiography and the study of equation-of-state of materials. Current research results will be presented.

  7. Observations of plasma structure and transport at high latitudes

    SciTech Connect

    Weber, E.J.; Buchau, J.

    1985-01-01

    Radio and optical diagnostics from the AFGL Airborne Ionospheric Observatory are used to study the structure and motion of regions of enhanced F-region density at high latitudes. Plasma flow can be tracked from the poleward edge of the dayside cusp, across the polar cap and into the nightside auroral zone. Simultaneous satellite amplitude and phase scintillation measurements define the degree of structuring or intensity of sub-kilometer ionospheric irregularities within these regions. The combined measurements are used to track large scale plasma flow, and to infer plasma source regions.

  8. High levels of plasma protein C in nephrotic syndrome.

    PubMed

    Pabinger-Fasching, I; Lechner, K; Niessner, H; Schmidt, P; Balzar, E; Mannhalter, C

    1985-02-18

    In patients with severe nephrotic syndrome determinations of plasma protein C: Ag levels (8 patients: 5 adults, 3 children) and protein C activity (3 out of 8 patients) revealed significantly elevated plasma protein C concentrations. Furthermore we observed a significant inverse correlation of protein C: Ag to AT III: Ag levels. No protein C: Ag could be detected in the urine of two patients studied. We conclude from our data, that changes of plasma protein C do not contribute to the high thrombotic tendency in nephrotic syndrome. PMID:3838827

  9. 'Abnormal' angle response curves of TW/Rs for near zero tilt and high tilt channeling implants

    SciTech Connect

    Guo Baonian; Gossmann, Hans-Joachim; Toh, Terry; Colombeau, Benjamin; Todorov, Stan; Sinclair, Frank; Shim, Kyu-Ha; Henry, Todd

    2012-11-06

    Angle control has been widely accepted as the key requirement for ion implantation in semiconductor device processing. From an ion implanter point of view, the incident ion direction should be measured and corrected by suitable techniques, such as XP-VPS for the VIISta implanter platform, to ensure precision ion placement in device structures. So called V-curves have been adopted to generate the wafer-based calibration using channeling effects as the Si lattice steer ions into a channeling direction. Thermal Wave (TW) or sheet resistance (Rs) can be used to determine the minimum of the angle response curve. Normally it is expected that the TW and Rs have their respective minima at identical angles. However, the TW and Rs response to the angle variations does depend on factors such as implant species, dose, and wafer temperature. Implant damage accumulation effects have to be considered for data interpretation especially for some 'abnormal' V-curve data. In this paper we will discuss some observed 'abnormal' angle responses, such as a) TW/Rs reverse trend for Arsenic beam, 2) 'W' shape of Rs Boron, and 3) apparent TW/Rs minimum difference for high tilt characterization, along with experimental data and TCAD simulations.

  10. Ultra-High Intensity Magnetic Field Generation in Dense Plasma

    SciTech Connect

    Fisch, Nathaniel J

    2014-01-08

    I. Grant Objective The main objective of this grant proposal was to explore the efficient generation of intense currents. Whereasthefficient generation of electric current in low-­energy-­density plasma has occupied the attention of the magnetic fusion community for several decades, scant attention has been paid to carrying over to high-­energy-­density plasma the ideas for steady-­state current drive developed for low-­energy-­density plasma, or, for that matter, to inventing new methodologies for generating electric current in high-­energy-­density plasma. What we proposed to do was to identify new mechanisms to accomplish current generation, and to assess the operation, physics, and engineering basis of new forms of current drive in regimes appropriate for new fusion concepts.

  11. Plasma-puff initiation of high Coulomb transfer switches

    NASA Technical Reports Server (NTRS)

    Venable, D. D.; Han, K. S.

    1993-01-01

    The plasma-puff triggering mechanism based on a hypocycloidal pinch geometry was investigated to determine the optimal operating conditions for an azimuthally uniform surface flashover which initiates plasma-puff under wide ranges of fill gas pressures of Ar, He and N2. The optimal fill gas pressures for the azimuthally uniform plasma-puff were about 120 mTorr less than P(opt) less than 450 Torr for He and N2. For Argon 120 mTorr less than P(opt) less than 5 Torr for argon. The inverse pinch switch was triggered with the plasma-puff and the switching capability under various electrical parameters and working gas pressures of Ar, He and N2 was determined. It was also shown that the azimuthally uniform switching discharges were dependent on the type of fill gas and its fill pressure. A new concept of plasma-focus driven plasma-puff was also discussed in comparison with hypocycloidal pinch plasma-puff triggering. The main discharge of the inverse pinch switch with the plasma-focus driven plasma-puff trigger is found to be more azimuthally uniform than that with the hypocycloidal pinch plasma-puff trigger in a gas pressure region between 80 mTorr and 1 Torr. In order to assess the effects of plasma current density on material erosion of electrodes, emissions from both an inverse-pinch plasma switch (INPIStron) and from a spark gap switch under test were studied with an optical multichannel analyzer (OMA). The color temperature of the argon plasma was approximately 4,000 K which corresponded with the peak continuum emission near 750 nm. There are the strong line emissions of argon in the 650 - 800 nm range and a lack of line emissions of copper and other solid material used in the switch. This indicates that the plasma current density during closing is low and the hot spot or hot filament in the switch is negligible. This result also indicates considerable reduction of line emission with the INPIStron switch over that of a spark-gap switch. However, a strong carbon line

  12. High-performance simulations for atmospheric pressure plasma reactor

    NASA Astrophysics Data System (ADS)

    Chugunov, Svyatoslav

    Plasma-assisted processing and deposition of materials is an important component of modern industrial applications, with plasma reactors sharing 30% to 40% of manufacturing steps in microelectronics production. Development of new flexible electronics increases demands for efficient high-throughput deposition methods and roll-to-roll processing of materials. The current work represents an attempt of practical design and numerical modeling of a plasma enhanced chemical vapor deposition system. The system utilizes plasma at standard pressure and temperature to activate a chemical precursor for protective coatings. A specially designed linear plasma head, that consists of two parallel plates with electrodes placed in the parallel arrangement, is used to resolve clogging issues of currently available commercial plasma heads, as well as to increase the flow-rate of the processed chemicals and to enhance the uniformity of the deposition. A test system is build and discussed in this work. In order to improve operating conditions of the setup and quality of the deposited material, we perform numerical modeling of the plasma system. The theoretical and numerical models presented in this work comprehensively describe plasma generation, recombination, and advection in a channel of arbitrary geometry. Number density of plasma species, their energy content, electric field, and rate parameters are accurately calculated and analyzed in this work. Some interesting engineering outcomes are discussed with a connection to the proposed setup. The numerical model is implemented with the help of high-performance parallel technique and evaluated at a cluster for parallel calculations. A typical performance increase, calculation speed-up, parallel fraction of the code and overall efficiency of the parallel implementation are discussed in details.

  13. Plasma Interaction with International Space Station High Voltage Solar Arrays

    NASA Technical Reports Server (NTRS)

    Heard, John W.

    2002-01-01

    The International Space Station (ISS) is presently being assembled in low-earth orbit (LEO) operating high voltage solar arrays (-160 V max, -140 V typical with respect to the ambient atmosphere). At the station's present altitude, there exists substantial ambient plasma that can interact with the solar arrays. The biasing of an object to an electric potential immersed in plasma creates a plasma "sheath" or non-equilibrium plasma around the object to mask out the electric fields. A positively biased object can collect electrons from the plasma sheath and the sheath will draw a current from the surrounding plasma. This parasitic current can enter the solar cells and effectively "short out" the potential across the cells, reducing the power that can be generated by the panels. Predictions of collected current based on previous high voltage experiments (SAMPIE (Solar Array Module Plasma Interactions Experiment), PASP+ (Photovoltaic Array Space Power) were on the order of amperes of current. However, present measurements of parasitic current are on the order of several milliamperes, and the current collection mainly occurs during an "eclipse exit" event, i.e., when the space station comes out of darkness. This collection also has a time scale, t approx. 1000 s, that is much slower than any known plasma interaction time scales. The reason for the discrepancy between predictions and present electron collection is not understood and is under investigation by the PCU (Plasma Contactor Unit) "Tiger" team. This paper will examine the potential structure within and around the solar arrays, and the possible causes and reasons for the electron collection of the array.

  14. High energy density Z-pinch plasmas using flow stabilization

    SciTech Connect

    Shumlak, U. Golingo, R. P. Nelson, B. A. Bowers, C. A. Doty, S. A. Forbes, E. G. Hughes, M. C. Kim, B. Knecht, S. D. Lambert, K. K. Lowrie, W. Ross, M. P. Weed, J. R.

    2014-12-15

    The ZaP Flow Z-Pinch research project[1] at the University of Washington investigates the effect of sheared flows on MHD instabilities. Axially flowing Z-pinch plasmas are produced that are 100 cm long with a 1 cm radius. The plasma remains quiescent for many radial Alfvén times and axial flow times. The quiescent periods are characterized by low magnetic mode activity measured at several locations along the plasma column and by stationary visible plasma emission. Plasma evolution is modeled with high-resolution simulation codes – Mach2, WARPX, NIMROD, and HiFi. Plasma flow profiles are experimentally measured with a multi-chord ion Doppler spectrometer. A sheared flow profile is observed to be coincident with the quiescent period, and is consistent with classical plasma viscosity. Equilibrium is determined by diagnostic measurements: interferometry for density; spectroscopy for ion temperature, plasma flow, and density[2]; Thomson scattering for electron temperature; Zeeman splitting for internal magnetic field measurements[3]; and fast framing photography for global structure. Wall stabilization has been investigated computationally and experimentally by removing 70% of the surrounding conducting wall to demonstrate no change in stability behavior.[4] Experimental evidence suggests that the plasma lifetime is only limited by plasma supply and current waveform. The flow Z-pinch concept provides an approach to achieve high energy density plasmas,[5] which are large, easy to diagnose, and persist for extended durations. A new experiment, ZaP-HD, has been built to investigate this approach by separating the flow Z-pinch formation from the radial compression using a triaxial-electrode configuration. This innovation allows more detailed investigations of the sheared flow stabilizing effect, and it allows compression to much higher densities than previously achieved on ZaP by reducing the linear density and increasing the pinch current. Experimental results and

  15. High energy density Z-pinch plasmas using flow stabilization

    NASA Astrophysics Data System (ADS)

    Shumlak, U.; Golingo, R. P.; Nelson, B. A.; Bowers, C. A.; Doty, S. A.; Forbes, E. G.; Hughes, M. C.; Kim, B.; Knecht, S. D.; Lambert, K. K.; Lowrie, W.; Ross, M. P.; Weed, J. R.

    2014-12-01

    The ZaP Flow Z-Pinch research project[1] at the University of Washington investigates the effect of sheared flows on MHD instabilities. Axially flowing Z-pinch plasmas are produced that are 100 cm long with a 1 cm radius. The plasma remains quiescent for many radial Alfvén times and axial flow times. The quiescent periods are characterized by low magnetic mode activity measured at several locations along the plasma column and by stationary visible plasma emission. Plasma evolution is modeled with high-resolution simulation codes - Mach2, WARPX, NIMROD, and HiFi. Plasma flow profiles are experimentally measured with a multi-chord ion Doppler spectrometer. A sheared flow profile is observed to be coincident with the quiescent period, and is consistent with classical plasma viscosity. Equilibrium is determined by diagnostic measurements: interferometry for density; spectroscopy for ion temperature, plasma flow, and density[2]; Thomson scattering for electron temperature; Zeeman splitting for internal magnetic field measurements[3]; and fast framing photography for global structure. Wall stabilization has been investigated computationally and experimentally by removing 70% of the surrounding conducting wall to demonstrate no change in stability behavior.[4] Experimental evidence suggests that the plasma lifetime is only limited by plasma supply and current waveform. The flow Z-pinch concept provides an approach to achieve high energy density plasmas,[5] which are large, easy to diagnose, and persist for extended durations. A new experiment, ZaP-HD, has been built to investigate this approach by separating the flow Z-pinch formation from the radial compression using a triaxial-electrode configuration. This innovation allows more detailed investigations of the sheared flow stabilizing effect, and it allows compression to much higher densities than previously achieved on ZaP by reducing the linear density and increasing the pinch current. Experimental results and scaling

  16. Plasma Physics, Fusion Science, and California High School Science

    NASA Astrophysics Data System (ADS)

    Correll, Donald

    2004-11-01

    In order to further engage California HIgh School science teachers in plasma physics and fusion science, a collaboration was formed between LLNL's Fusion Energy Program and the University of California's Edward Teller Education Center (etec.ucdavis.edu). California's Science Content Standards for high school physics (www.cde.ca.gov/be/st/ss/scphysics.asp) were used to create a public lecture (education.llnl.gov/sos/) that covered "students are expected to achieve" physics topics relevant to astrophysical and fusion plasma research. In addition to the lecture, a two day workshop for the Edward Teller Education Symposium, September 24 - 25, 2004 (education.llnl.gov/symposium2004) was designed around plasma spectroscopy (education.llnl.gov/symposium2004/agenda_astro.html). Plasma spectroscopy was chosen as the "anchor" to the workshop given the breadth and depth of the field to both astrophysical and fusion plasma research. Workshop participation includes lectures, tours, spectroscopic measurements, and building a 'spectroscope' for use in the teachers' respective high school classrooms. Accomplishments will be reported and future plans will be presented that include development of a one to two week expanded workshop that includes plasma research methods and advanced science skills essential to guiding students to conduct research projects.

  17. Progress on Development of Low Pressure High Density Plasmas on the Helicon Plasma Experiment (HPX)

    NASA Astrophysics Data System (ADS)

    James, R. W.; Duke-Tinson, O.; Nolan, S.; Page, E. J.; Lopez, M.; Karama, J.; Paolino, R. N.; Schlank, C.; Sherman, J.; Stutzman, B. S.; Crilly, P. B.

    2013-10-01

    At the Coast Guard Academy Plasma Lab (CGAPL), a small Helicon Plasma Experiment (HPX) is being developed to utilize the reputed high densities (1013 cm-3 and higher) at low pressure (.01 T), for eventual high temperature and density diagnostic development in future laboratory investigations. HPX is designed to create repeatedly stable plasmas induced by an RF frequency in the 10 to 70 MHz range. We employ a 400 to 1000 Gauss electromagnet that promotes energy conservation in the plasma via external energy production in the magnetic field facilitated by decreased inertial effects, in order to reach the Helicon Mode. With the initial construction phase complete and repeatable plasmas attained, HPX is constructing triple and mach particle probes, magnetic probes, and a single point 300 W Thompson Scattering system backed by a 32-channel Data Acquisition (DAQ) system capable 12 bits of sampling precision at 2 MS/s for HPX plasma property investigations. Progress on the development of the RF coupling system, Helicon Mode development, magnetic coils, and observations from the optical, particle, and electromagnetic scattering diagnostics will be reported. Supported by U.S. DEPS Grant [HEL-JTO] PRWJFY12.

  18. Downstream plasma transport and metal ionization in a high-powered pulsed-plasma magnetron

    SciTech Connect

    Meng, Liang; Szott, Matthew M.; McLain, Jake T.; Ruzic, David N.; Yu, He

    2014-06-14

    Downstream plasma transport and ionization processes in a high-powered pulsed-plasma magnetron were studied. The temporal evolution and spatial distribution of electron density (n{sub e}) and temperature (T{sub e}) were characterized with a 3D scanning triple Langmuir probe. Plasma expanded from the racetrack region into the downstream region, where a high n{sub e} peak was formed some time into the pulse-off period. The expansion speed and directionality towards the substrate increased with a stronger magnetic field (B), largely as a consequence of a larger potential drop in the bulk plasma region during a relatively slower sheath formation. The fraction of Cu ions in the deposition flux was measured on the substrate using a gridded energy analyzer. It increased with higher pulse voltage. With increased B field from 200 to 800 Gauss above racetrack, n{sub e} increased but the Cu ion fraction decreased from 42% to 16%. A comprehensive model was built, including the diffusion of as-sputtered Cu flux, the Cu ionization in the entire plasma region using the mapped n{sub e} and T{sub e} data, and ion extraction efficiency based on the measured plasma potential (V{sub p}) distribution. The calculations matched the measurements and indicated the main causes of lower Cu ion fractions in stronger B fields to be the lower T{sub e} and inefficient ion extraction in a larger pre-sheath potential.

  19. Downstream plasma transport and metal ionization in a high-powered pulsed-plasma magnetron

    NASA Astrophysics Data System (ADS)

    Meng, Liang; Yu, He; Szott, Matthew M.; McLain, Jake T.; Ruzic, David N.

    2014-06-01

    Downstream plasma transport and ionization processes in a high-powered pulsed-plasma magnetron were studied. The temporal evolution and spatial distribution of electron density (ne) and temperature (Te) were characterized with a 3D scanning triple Langmuir probe. Plasma expanded from the racetrack region into the downstream region, where a high ne peak was formed some time into the pulse-off period. The expansion speed and directionality towards the substrate increased with a stronger magnetic field (B), largely as a consequence of a larger potential drop in the bulk plasma region during a relatively slower sheath formation. The fraction of Cu ions in the deposition flux was measured on the substrate using a gridded energy analyzer. It increased with higher pulse voltage. With increased B field from 200 to 800 Gauss above racetrack, ne increased but the Cu ion fraction decreased from 42% to 16%. A comprehensive model was built, including the diffusion of as-sputtered Cu flux, the Cu ionization in the entire plasma region using the mapped ne and Te data, and ion extraction efficiency based on the measured plasma potential (Vp) distribution. The calculations matched the measurements and indicated the main causes of lower Cu ion fractions in stronger B fields to be the lower Te and inefficient ion extraction in a larger pre-sheath potential.

  20. Ion species control in high flux deuterium plasma beams produced by a linear plasma generator

    SciTech Connect

    Luo, G.-N.; Shu, W.M.; Nakamura, H.; O'Hira, S.; Nishi, M.

    2004-11-01

    The ion species ratios in low energy high flux deuterium plasma beams formed in a linear plasma generator were measured by a quadrupole mass spectrometer. And the species control in the plasma generator was evaluated by changing the operational parameters like neutral pressure, arc current, and axial magnetic confinement to the plasma column. The measurements reveal that the lower pressures prefer to form more D{sup +} ions, and the medium magnetic confinement at the higher pressures results in production of more D{sub 2}{sup +}, while the stronger confinement and/or larger arc current are helpful to D{sub 2}{sup +} conversion into D{sub 3}{sup +}. Therefore, the ion species can be controlled by adjusting the operational parameters of the plasma generator. With suitable adjustment, we can achieve plasma beams highly enriched with a single species of D{sup +}, D{sub 2}{sup +}, or D{sub 3}{sup +}, to a ratio over 80%. It has been found that the axial magnetic configuration played a significant role in the formation of D{sub 3}{sup +} within the experimental pressure range.

  1. Numerical Studies of High-Z Plasma in the HyperV Plasma Guns

    NASA Astrophysics Data System (ADS)

    Wu, Linchun; Messer, Sarah; Witherspoon, F. Douglas; Welch, Dale; Thoma, Carsten; Phillips, Mike; Bogatu, I. Nick; Galkin, Sergei; Macfarlane, Joe; Golovkin, Igor

    2010-11-01

    Numerical studies of railguns and coaxial guns at HyperV Technologies Corp. include simulations of hypervelocity plasma transport in the gun, plasma expansion out of the nozzle, and two or more jets merging in vacuum. Plasma detachment, merging jets temperature and charge state evolution are examined in these processes. High-Z materials, such as argon and xenon, are used throughout these simulations. The plasma moves with an initial velocity of 0-10 km/s (80-100 km/s for jet merging), the initial number density ranges from 10^15cm-3 to 10^18cm-3, and the merging jets are several centimeters in radius. The LSP code is used to perform the simulations using improved fluid algorithms and equation-of-state models from Voss and atomic data from Prism.

  2. Magnetohydrodynamic transport equations for high current propagation in overdense plasmas

    NASA Astrophysics Data System (ADS)

    Zha, Xuejun; Wang, Yan; Han, Shensheng

    2008-10-01

    In this paper, it is presented that the full set of magnetohydrodynamic (MHD) equations which may be used to study the transport mechanism for the high current relativistic electron beams (current intensity 100˜1000 MA, electron energy ˜ MeV) by the laser in background overdense plasma (1022-1026cm). The transport of intense relativistic electron beams (REB) has two basic characteristics: the first is that the forward current is a giga-ampere and the forward current density is about 10 14 A/cm 2 which exceeds the Alfven current limit [M. Tabak et al., Phys. Plasmas 12, 057305 (2005)]; the second is the propagation of the intense forward current in the presence of a background overdense plasma which may have very strong MHD instability. The transport problem can be solved by MHD equations that describe the dynamic, self consistent collisional and electromagnetic interaction of REB with overdense hydrogenic plasmas or arbitrary atomic-number plasmas. The full set of equations consists of the REB transport equations which are coupled to Maxwell's equations through the electromagnetic-field terms and two-fluid plasma dynamical equations for the background overdense plasma through the collision term.

  3. Distinct Patterns of Grey Matter Abnormality in High-Functioning Autism and Asperger's Syndrome

    ERIC Educational Resources Information Center

    McAlonan, Grainne M.; Suckling, John; Wong, Naikei; Cheung, Vinci; Lienenkaemper, Nina; Cheung, Charlton; Chua, Siew E.

    2008-01-01

    Background: Autism exists across a wide spectrum and there is considerable debate as to whether children with Asperger's syndrome, who have normal language milestones, should be considered to comprise a subgroup distinct other from high-functioning children with autism (HFA), who have a history of delayed language development. Magnetic resonance…

  4. Damage-controlled high power lasers and plasma mirror application

    NASA Astrophysics Data System (ADS)

    Kiriyama, Hiromitsu; Ochi, Yoshihiro; Nishikino, Masaharu; Nagashima, Keisuke; Kawachi, Tetsuya; Itakura, Ryoji; Sugiyama, Akira; Kando, Masaki; Pirozhkov, A. S.; Nishiuchi, Mamiko; Bulanov, Sergei V.; Kondo, Kimonori; Kato, Yoshiaki

    2015-07-01

    Following three different types of high power lasers at Kansai Photon Science Institute are overviewed and controlling the laser damages in these laser systems are described: (1) PW-class Ti:sapphire laser for high field science, (2) zig-zag slab Nd:glass laser for x-ray laser pumping, and (3) high-repetition Yb:YAG thin-slab laser for THz generation. Also reported is the use of plasma mirror for characterization of short-wavelength ultrashort laser pulses. This new method will be useful to study evolution of plasma formation which leads to laser damages.

  5. High-Energy Two-Stage Pulsed Plasma Thruster

    NASA Technical Reports Server (NTRS)

    Markusic, Tom

    2003-01-01

    A high-energy (28 kJ per pulse) two-stage pulsed plasma thruster (MSFC PPT-1) has been constructed and tested. The motivation of this project is to develop a high power (approximately 500 kW), high specific impulse (approximately 10000 s), highly efficient (greater than 50%) thruster for use as primary propulsion in a high power nuclear electric propulsion system. PPT-1 was designed to overcome four negative characteristics which have detracted from the utility of pulsed plasma thrusters: poor electrical efficiency, poor propellant utilization efficiency, electrode erosion, and reliability issues associated with the use of high speed gas valves and high current switches. Traditional PPTs have been plagued with poor efficiency because they have not been operated in a plasma regime that fully exploits the potential benefits of pulsed plasma acceleration by electromagnetic forces. PPTs have generally been used to accelerate low-density plasmas with long current pulses. Operation of thrusters in this plasma regime allows for the development of certain undesirable particle-kinetic effects, such as Hall effect-induced current sheet canting. PPT-1 was designed to propel a highly collisional, dense plasma that has more fluid-like properties and, hence, is more effectively pushed by a magnetic field. The high-density plasma loading into the second stage of the accelerator is achieved through the use of a dense plasma injector (first stage). The injector produces a thermal plasma, derived from a molten lithium propellant feed system, which is subsequently accelerated by the second stage using mega-amp level currents, which eject the plasma at a speed on the order of 100 kilometers per second. Traditional PPTs also suffer from dynamic efficiency losses associated with snowplow loading of distributed neutral propellant. The twostage scheme used in PPT-I allows the propellant to be loaded in a manner which more closely approximates the optimal slug loading. Lithium propellant

  6. Modeling of High Kinetic Energy Plasma Jets for Fusion Applications

    NASA Astrophysics Data System (ADS)

    Bogatu, I. N.; Galkin, S. A.; Kim, J. S.

    2006-10-01

    We used semi-analytical models for high velocity (>200 km/s) and density (>10^17 cm-3) plasma jets to describe the acceleration in coaxial electrodes geometry, the collision, and plasma liner implosion, assuming that jets have merged into a spherical or cylindrical shell. The results are compared with experimental data and are being used for guiding LSP and MACH2 codes simulation and for optimization. The simplest model which uses the adiabatic invariant for oscillator revealed the basic relation between the velocity and the parameters of the plasma accelerator. Plasma slug model was extended for including friction and mass addition by electrode erosion. A simple model of blow-by instability by using the canting angle of the plasma current was formulated. As plasma jets collision at high interfacial Mach number generates shock fronts, we analyzed their possible consequences on the merging process and liner formation. The structure of the spherical shell liner during adiabatic implosion and the effect of the shock wave generated at void closure on the confinement time were also investigated.

  7. Dust accelerators and their applications in high-temperature plasmas

    SciTech Connect

    Wang, Zhehui; Ticos, Catakin M

    2010-01-01

    The perennial presence of dust in high-temperature plasma and fusion devices has been firmly established. Dust inventory must be controlled, in particular in the next-generation steady-state fusion machines like ITER, as it can pose significant safety hazards and potentially interfere with fusion energy production. Much effort has been devoted to gening rid of the dust nuisance. We have recognized a number of dust-accelerators applications in magnetic fusion, including in plasma diagnostics, in studying dust-plasma interactions, and more recently in edge localized mode (ELM)'s pacing. With the applications in mind, we will compare various acceleration methods, including electrostatic, gas-drag, and plasma-drag acceleration. We will also describe laboratory experiments and results on dust acceleration.

  8. High-frequency extensions of magnetorotational instability in astrophysical plasmas

    SciTech Connect

    Mikhailovskii, A. B.; Lominadze, J. G.; Churikov, A. P.; Pustovitov, V. D.; Erokhin, N. N.; Tsypin, V. S.; Galvao, R. M. O.

    2008-08-15

    High-frequency extensions of magnetorotational instability driven by the Velikhov effect beyond the standard magnetohydrodynamic (MHD) regime are studied. The existence of the well-known Hall regime and a new electron inertia regime is demonstrated. The electron inertia regime is realized for a lesser plasma magnetization of rotating plasma than that in the Hall regime. It includes the subregime of nonmagnetized electrons. It is shown that, in contrast to the standard MHD regime and the Hall regime, magnetorotational instability in this subregime can be driven only at positive values of dln{Omega}/dlnr, where {Omega} is the plasma rotation frequency and r is the radial coordinate. The permittivity of rotating plasma beyond the standard MHD regime, including both the Hall regime and the electron inertia regime, is calculated.

  9. Dust Accelerators And Their Applications In High-Temperature Plasmas

    NASA Astrophysics Data System (ADS)

    Ticoş, Cǎtǎlin M.; Wang, Zhehui

    2011-06-01

    The perennial presence of dust in high-temperature plasma and fusion devices has been firmly established. Dust inventory must be controlled, in particular in the next-generation steady-state fusion machines like ITER, as it can pose significant safety hazards and potentially interfere with fusion energy production. Although much effort has been devoted to getting rid of the dust nuisance, there are instances where a controlled use of dust can be beneficial. We have recognized a number of dust-accelerators applications in magnetic fusion, including in plasma diagnostics, in studying dust-plasma interactions, and more recently in edge localized mode (ELM)'s pacing. With the applications in mind, we will compare various acceleration methods, including electrostatic, gas-drag, and plasma-drag acceleration. We will also describe laboratory experiments and results on dust acceleration.

  10. Production of H, D, and He Plasmas in the ORNL High Flux Helicon Plasma Source

    NASA Astrophysics Data System (ADS)

    Goulding, R. H.; Biewer, T. M.; Caughman, J. B. O.; Chen, G. C.; Owen, L. W.; Sparks, D. O.

    2011-10-01

    The ORNL high particle flux helicon source is has been operated with various light ions at power levels up to 30 kW. It is being studied as an electrodeless source for a linear plasma materials interaction (PMI) test facility that will generate particle fluxes Γp >1023m-3s-1 , and utilize additional ion and electron cyclotron heating to produce high heat fluxes ~ 10 MW /m2 . The maximum magnetic field strength | B | in the plasma production region for which high density operation is possible at the present power level has been found to increase with increasing ion mass. Operation with | B | ~ 0 . 5 T has been achieved with He as the working gas. The radial density profile is found to be strongly dependent on the axial magnetic field geometry, and both strongly centrally peaked and flat profiles have been obtained. Maximum plasma densities > 4 ×1019m-3 have been achieved with He, and > 2 . 5 ×1019m-3 with H. The device has been modeled using the EMS2D (G. Chen et al., Phys Plasmas 13 (2006) 123507) and SOLPS (R. Schneider, X. Bonnin et al., Contrib. Plasma Phys. 46 (2006) 3) codes. The latest results will be presented. ORNL is managed by UT-Batelle, LLC, for the U.S. Dept of Energy under contract DE-AC-05-00OR22725.

  11. High Fat Diet Produces Brain Insulin Resistance, Synaptodendritic Abnormalities and Altered Behavior in Mice

    PubMed Central

    Arnold, Steven E.; Lucki, Irwin; Brookshire, Bethany R.; Carlson, Gregory C.; Browne, Carolyn A.; Kazi, Hala; Bang, Sookhee; Choi, Bo-Ran; Chen, Yong; McMullen, Mary F.; Kim, Sangwon F.

    2014-01-01

    Insulin resistance and other features of the metabolic syndrome are increasingly recognized for their effects on cognitive health. To ascertain mechanisms by which this occurs, we fed mice a very high fat diet (60% kcal by fat) for 17 days or a moderate high fat diet (HFD, 45% kcal by fat) for 8 weeks and examined changes in brain insulin signaling responses, hippocampal synaptodendritic protein expression, and spatial working memory. Compared to normal control diet mice, cerebral cortex tissues of HFD mice were insulin-resistant as evidenced by failed activation of Akt, S6 and GSK3β with ex-vivo insulin stimulation. Importantly, we found that expression of brain IPMK, which is necessary for mTOR/Akt signaling, remained decreased in HFD mice upon activation of AMPK. HFD mouse hippocampus exhibited increased expression of serine-phosphorylated insulin receptor substrate 1 (IRS1-pS616), a marker of insulin resistance, as well as decreased expression of PSD-95, a scaffolding protein enriched in post-synaptic densities, and synaptopodin, an actin-associated protein enriched in spine apparatuses. Spatial working memory was impaired as assessed by decreased spontaneous alternation in a T-maze. These findings indicate that HFD is associated with telencephalic insulin resistance and deleterious effects on synaptic integrity and cognitive behaviors. PMID:24686304

  12. High repetition rate plasma mirror device for attosecond science

    SciTech Connect

    Borot, A.; Douillet, D.; Iaquaniello, G.; Lefrou, T.; Lopez-Martens, R.; Audebert, P.; Geindre, J.-P.

    2014-01-15

    This report describes an active solid target positioning device for driving plasma mirrors with high repetition rate ultra-high intensity lasers. The position of the solid target surface with respect to the laser focus is optically monitored and mechanically controlled on the nm scale to ensure reproducible interaction conditions for each shot at arbitrary repetition rate. We demonstrate the target capabilities by driving high-order harmonic generation from plasma mirrors produced on glass targets with a near-relativistic intensity few-cycle pulse laser system operating at 1 kHz. During experiments, residual target surface motion can be actively stabilized down to 47 nm (root mean square), which ensures sub-300-as relative temporal stability of the plasma mirror as a secondary source of coherent attosecond extreme ultraviolet radiation in pump-probe experiments.

  13. High repetition rate plasma mirror device for attosecond science

    NASA Astrophysics Data System (ADS)

    Borot, A.; Douillet, D.; Iaquaniello, G.; Lefrou, T.; Audebert, P.; Geindre, J.-P.; Lopez-Martens, R.

    2014-01-01

    This report describes an active solid target positioning device for driving plasma mirrors with high repetition rate ultra-high intensity lasers. The position of the solid target surface with respect to the laser focus is optically monitored and mechanically controlled on the nm scale to ensure reproducible interaction conditions for each shot at arbitrary repetition rate. We demonstrate the target capabilities by driving high-order harmonic generation from plasma mirrors produced on glass targets with a near-relativistic intensity few-cycle pulse laser system operating at 1 kHz. During experiments, residual target surface motion can be actively stabilized down to 47 nm (root mean square), which ensures sub-300-as relative temporal stability of the plasma mirror as a secondary source of coherent attosecond extreme ultraviolet radiation in pump-probe experiments.

  14. High repetition rate plasma mirror device for attosecond science.

    PubMed

    Borot, A; Douillet, D; Iaquaniello, G; Lefrou, T; Audebert, P; Geindre, J-P; Lopez-Martens, R

    2014-01-01

    This report describes an active solid target positioning device for driving plasma mirrors with high repetition rate ultra-high intensity lasers. The position of the solid target surface with respect to the laser focus is optically monitored and mechanically controlled on the nm scale to ensure reproducible interaction conditions for each shot at arbitrary repetition rate. We demonstrate the target capabilities by driving high-order harmonic generation from plasma mirrors produced on glass targets with a near-relativistic intensity few-cycle pulse laser system operating at 1 kHz. During experiments, residual target surface motion can be actively stabilized down to 47 nm (root mean square), which ensures sub-300-as relative temporal stability of the plasma mirror as a secondary source of coherent attosecond extreme ultraviolet radiation in pump-probe experiments. PMID:24517742

  15. The behavior of the electron plasma boundary in ultraintense laser–highly overdense plasma interaction

    SciTech Connect

    Sánchez-Arriaga, G.; Sanz, J.; Debayle, A.; Lehmann, G.

    2014-12-15

    The structural stability of the laser/plasma interaction is discussed, for the case of a linearly polarized laser beam interacting with a solid at normal incidence. Using a semi-analytical cold fluid model, the dynamics of the electron plasma boundary (EPB), usually related to the high-order harmonic generation and laser absorption, are presented. While the well-known J × B plasma oscillations at two times the laser frequency are recovered by the model, several other periodic in time stable solutions exist for exactly the same value of the physical parameters. This novel behavior highlights the importance of the laser pulse history among other factors. Some important features, such as the synchronization between the incident laser and the EPB oscillation, depend on the solution under consideration. A description of the possible types of stable oscillations in a parametric plane involving plasma density and laser amplitude is presented. The semi-analytical model is compared with particle-in-cell and semi-Lagrangian Vlasov simulations. They show that, among all the stable solutions, the plasma preferentially evolves to a state with the EPB oscillating twice faster than the laser. The effect of the plasma temperature and the existence of a ramp in the ion density profile are also discussed.

  16. Behavioral and neurochemical abnormalities after exposure to low doses of high-energy iron particles.

    PubMed

    Hunt, W A; Joseph, J A; Rabin, B M

    1989-01-01

    Exposure of rats to high-energy iron particles (600 MeV/amu) has been found to alter behavior after doses as low as 10 rads. The performance of a task that measures upper body strength was significantly degraded after irradiation. In addition, an impairment in the regulation of dopamine release in the caudate nucleus (a motor center in the brain), lasting at least 6 months, was also found and correlated with the performance deficits. A general indication of behavioral toxicity and an index of nausea and emesis, the conditioned taste aversion, was also evident. The sensitivity to iron particles was 10-600 times greater than to gamma photons. These results suggest that behavioral and neurobiological damage may be a consequence of exposure to low doses of heavy particles and that this possibility should be extensively studied. PMID:11537313

  17. Behavioral and neurochemical abnormalities after exposure to low doses of high-energy iron particles

    NASA Astrophysics Data System (ADS)

    Hunt, Walter A.; Joseph, James A.; Rabin, Bernard M.

    Exposure of rats to high-energy iron particles (600 MeV/amu) has been found to alter behavior after doses as low as 10 rads. The performance of a task that measures upper body strength was significantly degraded after irradiation. In addition, an impairment in the regulation of dopamine release in the caudate nucleus (a motor center in the brain), lasting at least 6 months, was also found and correlated with the performance deficits. A general indication of behavioral toxicity and an index of nausea and emesis, the conditioned taste aversion, was also evident. The sensitivity to iron particles was 10-600 times greater than to gamma photons. These results suggest that behavioral and neurobiological damage may be a consequence of exposure to low doses of heavy particles and that this possibility should be extensively studied.

  18. Current source imaging for high spatial resolution magnetocardiography in normal and abnormal rat cardiac muscles

    NASA Astrophysics Data System (ADS)

    Uchida, S.; Iramina, K.; Goto, K.; Ueno, S.

    2000-05-01

    The purpose of our study was to identify the current source produced by acute ischemia and infarction. We measured magnetocardiograms (MCG) and electrocardiograms (ECG) of five male rats using a high-resolution dc superconducting quantum interference device gradiometer in a magnetically shielded room after performing coronary artery occlusion. The spatial resolution of the detecting magnetic field of our system is higher than the typical system, thus permitting the measurement of magnetic fields in small animals. Distribution of the magnetic fields B(t) and distribution of |rot B(t)|, which corresponded to the distribution of the current source, were imaged by 12-channel MCGs. As a result, the distribution of current source changes in the affected area of the myocardium during the ST segment, and amplitude of the peak significantly increased after occlusion. Our system can be used to help clarify the mechanism of the ST shift related to severe heart disease.

  19. Behavioral and neurochemical abnormalities after exposure to low doses of high-energy iron particles

    SciTech Connect

    Hunt, W.A.; Joseph, J.A.; Rabin, B.M.

    1989-01-01

    Exposure of rats to high-energy iron particles (600 MeV/amu) has been found to alter behavior after doses as low as 10 rads. The performance of a task that measures upper body strength was significantly degraded after irradiation. In addition, an impairment in the regulation of dopamine release in the caudate nucleus (a motor center in the brain), lasting at least 6 months, was also found and correlated with the performance deficits. A general indication of behavioral toxicity and an index of nausea and emesis, the conditioned taste aversion, was also evident. The sensitivity to iron particles was 10-600 times greater than to gamma photons. These results suggest that behavioral and neurobiological damage may be a consequence of exposure to low doses of heavy particles and that this possibility should be extensively studied.

  20. High Doses of Bone Morphogenetic Protein 2 Induce Structurally Abnormal Bone and Inflammation In Vivo

    PubMed Central

    Zara, Janette N.; Siu, Ronald K.; Zhang, Xinli; Shen, Jia; Ngo, Richard; Lee, Min; Li, Weiming; Chiang, Michael; Chung, Jonguk; Kwak, Jinny; Wu, Benjamin M.; Ting, Kang

    2011-01-01

    The major Food and Drug Association–approved osteoinductive factors in wide clinical use are bone morphogenetic proteins (BMPs). Although BMPs can promote robust bone formation, they also induce adverse clinical effects, including cyst-like bone formation and significant soft tissue swelling. In this study, we evaluated multiple BMP2 doses in a rat femoral segmental defect model and in a minimally traumatic rat femoral onlay model to determine its dose-dependent effects. Results of our femoral segmental defect model established a low BMP2 concentration range (5 and 10 μg/mL, total dose 0.375 and 0.75 μg in 75 μg total volume) unable to induce defect fusion, a mid-range BMP2 concentration range able to fuse the defect without adverse effects (30 μg/mL, total dose 2.25 μg in 75 μg total volume), and a high BMP2 concentration range (150, 300, and 600 μg/mL, total dose 11.25, 22.5, and 45 μg in 75 μg total volume) able to fuse the defect, but with formation of cyst-like bony shells filled with histologically confirmed adipose tissue. In addition, compared to control, 4 mg/mL BMP2 also induced significant tissue inflammatory infiltrates and exudates in the femoral onlay model that was accompanied by increased numbers of osteoclast-like cells at 3, 7, and 14 days. Overall, we consistently reproduced BMP2 side effects of cyst-like bone and soft tissue swelling using high BMP2 concentration approaching the typical human 1500 μg/mL. PMID:21247344

  1. High doses of bone morphogenetic protein 2 induce structurally abnormal bone and inflammation in vivo.

    PubMed

    Zara, Janette N; Siu, Ronald K; Zhang, Xinli; Shen, Jia; Ngo, Richard; Lee, Min; Li, Weiming; Chiang, Michael; Chung, Jonguk; Kwak, Jinny; Wu, Benjamin M; Ting, Kang; Soo, Chia

    2011-05-01

    The major Food and Drug Association-approved osteoinductive factors in wide clinical use are bone morphogenetic proteins (BMPs). Although BMPs can promote robust bone formation, they also induce adverse clinical effects, including cyst-like bone formation and significant soft tissue swelling. In this study, we evaluated multiple BMP2 doses in a rat femoral segmental defect model and in a minimally traumatic rat femoral onlay model to determine its dose-dependent effects. Results of our femoral segmental defect model established a low BMP2 concentration range (5 and 10 μg/mL, total dose 0.375 and 0.75 μg in 75 μg total volume) unable to induce defect fusion, a mid-range BMP2 concentration range able to fuse the defect without adverse effects (30 μg/mL, total dose 2.25 μg in 75 μg total volume), and a high BMP2 concentration range (150, 300, and 600 μg/mL, total dose 11.25, 22.5, and 45 μg in 75 μg total volume) able to fuse the defect, but with formation of cyst-like bony shells filled with histologically confirmed adipose tissue. In addition, compared to control, 4 mg/mL BMP2 also induced significant tissue inflammatory infiltrates and exudates in the femoral onlay model that was accompanied by increased numbers of osteoclast-like cells at 3, 7, and 14 days. Overall, we consistently reproduced BMP2 side effects of cyst-like bone and soft tissue swelling using high BMP2 concentration approaching the typical human 1500 μg/mL. PMID:21247344

  2. X-ray lasers and high-density plasma

    SciTech Connect

    1995-03-01

    The improved reliability, high brightness, and short wavelength of x-ray lasers make them ideally suited for studying large, high-density plasmas of interest to the laser-fusion research community. We have been developing the neonlike yttrium x-ray laser as a probe, together with the necessary multilayer mirrors and beam splitters, to image plasmas produced at the Nova laser facility and to measure electron density. With its short-wavelength (15.5-nm) light, we can use the yttrium x-ray laser to probe plasma densities up to 10{sup 23} cm{sup {minus}3}. At the highest magnification (30?), the spatial resolution of our imaging system is better than 1 {mu}m. Using the technique of moire deflectometry, we have measured density gradients of plasmas. Using the technique of interferometry, we have probed 3-mm-long plasmas with electron densities up to 3? 10{sup 21} cm{sup {minus}3}. Temporal blurring of plasma images remains the main limitation of our approach. Thus, we are continuing to improve our theoretical and experimental understanding of laboratory x-ray lasers. We are currently working on techniques to reduce the blurring of images by shortening the x-ray laser pulse to durations approaching about 20 ps. In the future, this important research tool can be applied to study high-density plasmas produced at the proposed National Ignition Facility. Other important applications of the x-ray laser include biological imaging of whole, live cells and other structures at resolutions superior to those obtainable by conventional optical microscopy.

  3. A tyrosinase with an abnormally high tyrosine hydroxylase/dopa oxidase ratio.

    PubMed

    Hernández-Romero, Diana; Sanchez-Amat, Antonio; Solano, Francisco

    2006-01-01

    The sequencing of the genome of Ralstonia solanacearum[Salanoubat M, Genin S, Artiguenave F, et al. (2002) Nature 415, 497-502] revealed several genes that putatively code for polyphenol oxidases (PPOs). This soil-borne pathogenic bacterium withers a wide range of plants. We detected the expression of two PPO genes (accession numbers NP_518458 and NP_519622) with high similarity to tyrosinases, both containing the six conserved histidines required to bind the pair of type-3 copper ions at the active site. Generation of null mutants in those genes by homologous recombination mutagenesis and protein purification allowed us to correlate each gene with its enzymatic activity. In contrast with all tyrosinases so far studied, the enzyme NP_518458 shows higher monophenolase than o-diphenolase activity and its initial activity does not depend on the presence of l-dopa cofactor. On the other hand, protein NP_519622 is an enzyme with a clear preference to oxidize o-diphenols and only residual monophenolase activity, behaving as a catechol oxidase. These catalytic characteristics are discussed in relation to two other characteristics apart from the six conserved histidines. One is the putative presence of a seventh histidine which interacts with the carboxy group on the substrate and controls the preference for carboxylated and decarboxylated substrates. The second is the size of the residue isosteric with the aromatic F261 reported in sweet potato catechol oxidase which acts as a gate to control accessibility to CuA at the active site. PMID:16403014

  4. Characteristics of extreme ultraviolet emission from high-Z plasmas

    NASA Astrophysics Data System (ADS)

    Ohashi, H.; Higashiguchi, T.; Suzuki, Y.; Kawasaki, M.; Suzuki, C.; Tomita, K.; Nishikino, M.; Fujioka, S.; Endo, A.; Li, B.; Otsuka, T.; Dunne, P.; O'Sullivan, G.

    2016-03-01

    We demonstrate the extreme ultraviolet (EUV) and soft x-ray sources in the 2 to 7 nm spectral region related to the beyond EUV (BEUV) question at 6.x nm and the water window source based on laser-produced high-Z plasmas. Resonance emission from multiply charged ions merges to produce intense unresolved transition arrays (UTAs), extending below the carbon K edge (4.37 nm). An outline of a microscope design for single-shot live cell imaging is proposed based on high-Z plasma UTA source, coupled to multilayer mirror optics.

  5. A high sensitivity momentum flux measuring instrument for plasma thruster exhausts and diffusive plasmas

    NASA Astrophysics Data System (ADS)

    West, Michael D.; Charles, Christine; Boswell, Rod W.

    2009-05-01

    A high sensitivity momentum flux measuring instrument based on a compound pendulum has been developed for use with electric propulsion devices and radio frequency driven plasmas. A laser displacement system, which builds upon techniques used by the materials science community for surface stress measurements, is used to measure with high sensitivity the displacement of a target plate placed in a plasma thruster exhaust. The instrument has been installed inside a vacuum chamber and calibrated via two different methods and is able to measure forces in the range of 0.02-0.5mN with a resolution of 15μN. Measurements have been made of the force produced from the cold gas flow and with a discharge ignited using argon propellant. The plasma is generated using a Helicon Double Layer Thruster prototype. The instrument target is placed about 1 mean free path for ion-neutral charge exchange collisions downstream of the thruster exit. At this position, the plasma consists of a low density ion beam (10%) and a much larger downstream component (90%). The results are in good agreement with those determined from the plasma parameters measured with diagnostic probes. Measurements at various flow rates show that variations in ion beam velocity and plasma density and the resulting momentum flux can be measured with this instrument. The instrument target is a simple, low cost device, and since the laser displacement system used is located outside the vacuum chamber, the measurement technique is free from radio frequency interference and thermal effects. It could be used to measure the thrust in the exhaust of other electric propulsion devices and the momentum flux of ion beams formed by expanding plasmas or fusion experiments.

  6. A high sensitivity momentum flux measuring instrument for plasma thruster exhausts and diffusive plasmas

    SciTech Connect

    West, Michael D.; Charles, Christine; Boswell, Rod W.

    2009-05-15

    A high sensitivity momentum flux measuring instrument based on a compound pendulum has been developed for use with electric propulsion devices and radio frequency driven plasmas. A laser displacement system, which builds upon techniques used by the materials science community for surface stress measurements, is used to measure with high sensitivity the displacement of a target plate placed in a plasma thruster exhaust. The instrument has been installed inside a vacuum chamber and calibrated via two different methods and is able to measure forces in the range of 0.02-0.5 mN with a resolution of 15 {mu}N. Measurements have been made of the force produced from the cold gas flow and with a discharge ignited using argon propellant. The plasma is generated using a Helicon Double Layer Thruster prototype. The instrument target is placed about 1 mean free path for ion-neutral charge exchange collisions downstream of the thruster exit. At this position, the plasma consists of a low density ion beam (10%) and a much larger downstream component (90%). The results are in good agreement with those determined from the plasma parameters measured with diagnostic probes. Measurements at various flow rates show that variations in ion beam velocity and plasma density and the resulting momentum flux can be measured with this instrument. The instrument target is a simple, low cost device, and since the laser displacement system used is located outside the vacuum chamber, the measurement technique is free from radio frequency interference and thermal effects. It could be used to measure the thrust in the exhaust of other electric propulsion devices and the momentum flux of ion beams formed by expanding plasmas or fusion experiments.

  7. A high sensitivity momentum flux measuring instrument for plasma thruster exhausts and diffusive plasmas.

    PubMed

    West, Michael D; Charles, Christine; Boswell, Rod W

    2009-05-01

    A high sensitivity momentum flux measuring instrument based on a compound pendulum has been developed for use with electric propulsion devices and radio frequency driven plasmas. A laser displacement system, which builds upon techniques used by the materials science community for surface stress measurements, is used to measure with high sensitivity the displacement of a target plate placed in a plasma thruster exhaust. The instrument has been installed inside a vacuum chamber and calibrated via two different methods and is able to measure forces in the range of 0.02-0.5 mN with a resolution of 15 microN. Measurements have been made of the force produced from the cold gas flow and with a discharge ignited using argon propellant. The plasma is generated using a Helicon Double Layer Thruster prototype. The instrument target is placed about 1 mean free path for ion-neutral charge exchange collisions downstream of the thruster exit. At this position, the plasma consists of a low density ion beam (10%) and a much larger downstream component (90%). The results are in good agreement with those determined from the plasma parameters measured with diagnostic probes. Measurements at various flow rates show that variations in ion beam velocity and plasma density and the resulting momentum flux can be measured with this instrument. The instrument target is a simple, low cost device, and since the laser displacement system used is located outside the vacuum chamber, the measurement technique is free from radio frequency interference and thermal effects. It could be used to measure the thrust in the exhaust of other electric propulsion devices and the momentum flux of ion beams formed by expanding plasmas or fusion experiments. PMID:19485509

  8. Application of Plasma Waveguides to High Energy Accelerators

    SciTech Connect

    Milchberg, Howard M

    2013-03-30

    The eventual success of laser-plasma based acceleration schemes for high-energy particle physics will require the focusing and stable guiding of short intense laser pulses in reproducible plasma channels. For this goal to be realized, many scientific issues need to be addressed. These issues include an understanding of the basic physics of, and an exploration of various schemes for, plasma channel formation. In addition, the coupling of intense laser pulses to these channels and the stable propagation of pulses in the channels require study. Finally, new theoretical and computational tools need to be developed to aid in the design and analysis of experiments and future accelerators. Here we propose a 3-year renewal of our combined theoretical and experimental program on the applications of plasma waveguides to high-energy accelerators. During the past grant period we have made a number of significant advances in the science of laser-plasma based acceleration. We pioneered the development of clustered gases as a new highly efficient medium for plasma channel formation. Our contributions here include theoretical and experimental studies of the physics of cluster ionization, heating, explosion, and channel formation. We have demonstrated for the first time the generation of and guiding in a corrugated plasma waveguide. The fine structure demonstrated in these guides is only possible with cluster jet heating by lasers. The corrugated guide is a slow wave structure operable at arbitrarily high laser intensities, allowing direct laser acceleration, a process we have explored in detail with simulations. The development of these guides opens the possibility of direct laser acceleration, a true miniature analogue of the SLAC RF-based accelerator. Our theoretical studies during this period have also contributed to the further development of the simulation codes, Wake and QuickPIC, which can be used for both laser driven and beam driven plasma based acceleration schemes. We

  9. Diastolic Dysfunction Induced by a High-Fat Diet Is Associated with Mitochondrial Abnormality and Adenosine Triphosphate Levels in Rats

    PubMed Central

    Kang, Ki-Woon; Kim, Ok-Soon; Chin, Jung Yeon; Kim, Won Ho; Park, Sang Hyun; Choi, Yu Jeong; Shin, Jong Ho; Jung, Kyung Tae; Lim, Do-Seon

    2015-01-01

    Background Obesity is well-known as a risk factor for heart failure, including diastolic dysfunction. However, this mechanism in high-fat diet (HFD)-induced obese rats remain controversial. The purpose of this study was to investigate whether cardiac dysfunction develops when rats are fed with a HFD for 10 weeks; additionally, we sought to investigate the association between mitochondrial abnormalities, adenosine triphosphate (ATP) levels and cardiac dysfunction. Methods We examined myocardia in Wistar rats after 10 weeks of HFD (45 kcal% fat, n=6) or standard diet (SD, n=6). Echocardiography, histomorphologic analysis, and electron microscopy were performed. The expression levels of mitochondrial oxidative phosphorylation (OXPHOS) subunit genes, peroxisome-proliferator-activated receptor γ co-activator-1α (PGC1α) and anti-oxidant enzymes were assessed. Markers of oxidative stress damage, mitochondrial DNA copy number and myocardial ATP level were also examined. Results After 10 weeks, the body weight of the HFD group (349.6±22.7 g) was significantly higher than that of the SD group (286.8±14.9 g), and the perigonadal and epicardial fat weights of the HFD group were significantly higher than that of the SD group. Histomorphologic and electron microscopic images were similar between the two groups. However, in the myocardium of the HFD group, the expression levels of OXPHOS subunit NDUFB5 in complex I and PGC1α, and the mitochondrial DNA copy number were decreased and the oxidative stress damage marker 8-hydroxydeoxyguanosine was increased, accompanied by reduced ATP levels. Conclusion Diastolic dysfunction was accompanied by the mitochondrial abnormality and reduced ATP levels in the myocardium of 10 weeks-HFD-induced rats. PMID:26790384

  10. High-frequency instability of the sheath-plasma resonance

    NASA Technical Reports Server (NTRS)

    Stenzel, R. L.

    1989-01-01

    Coherent high frequency oscillations near the electron plasma frequency (omega approx. less than omega sub p) are generated by electrodes with positive dc bias immersed in a uniform Maxwellian afterglow plasma. The instability occurs at the sheath-plasma resonance and is driven by a negative RF sheath resistance associated with the electron inertia in the diode-like electron-rich sheath. With increasing dc bias, i.e., electron transit time, the instability exhibits a hard threshold, downward frequency pulling, line broadening and copious harmonics. The fundamental instability is a bounded oscillation due to wave evanescence, but the harmonics are radiated as electromagnetic waves from the electrodes acting like antennas. Wavelength and polarization measurements confirm the emission process. Electromagnetic waves are excited by electrodes of various geometries (planes, cylinders, spheres) which excludes other radiation mechanisms such as orbitrons or beam-plasma instabilities. The line broadening mechanism was identified as a frequency modulation via the electron transit time by dynamic ions. Ion oscillations at the sheath edge give rise to burst-like RF emissions. These laboratory observations of a new instability are important for antennas in space plasmas, generation of coherent beams with diodes, and plasma diagnostics.

  11. In vivo protection against endotoxin by plasma high density lipoprotein.

    PubMed Central

    Levine, D M; Parker, T S; Donnelly, T M; Walsh, A; Rubin, A L

    1993-01-01

    Overwhelming bacterial infection is accompanied by fever, hypotension, disseminated intravascular coagulation, and multiple organ failure leading to death in 30-80% of cases. These classical symptoms of septic shock are caused by potent cytokines that are produced in response to endotoxin released from Gram-negative bacteria. Treatments with antibodies and receptor antagonists to block endotoxin or cytokine mediators have given mixed results in clinical trials. High density lipoprotein (HDL) is a natural component of plasma that is known to neutralize endotoxin in vitro. We report here that raising the plasma HDL concentration protects mice against endotoxin in vivo. Transgenic mice with 2-fold-elevated plasma HDL levels had more endotoxin bound to HDL, lower plasma cytokine levels, and improved survival rates compared with low-HDL mice. Intravenous infusion of HDL also protected mice, but only when given as reconstituted HDL prepared from phospholipid and either HDL apoprotein or an 18-amino acid peptide synthesized to mimic the structure of apolipoprotein A-I of HDL. Intact plasma HDL was mildly toxic, and HDL apoprotein was ineffective. The effectiveness of the reconstituted peptide renders very unlikely any significant contribution to protection by trace proteins in apo-HDL. These data suggest a simple leaflet insertion model for binding and neutralization of lipopolysaccharide by phospholipid on the surface of HDL. Plasma HDL may normally act to protect against endotoxin; this protection may be augmented by administration of reconstituted HDL or reconstituted peptides. Images Fig. 1 Fig. 2 Fig. 3 PMID:8265667

  12. Progress on Development of Low Pressure High Density Plasmas on the Helicon Plasma Experiment (HPX)

    NASA Astrophysics Data System (ADS)

    James, Royce; Azzari, Phillip; Duke-Tinson, Omar; Frank, John; Karama, Jackson; Hopson, Jordan; Paolino, Richard; Sandri, Eva; Sherman, Justin; Wright, Erin; Turk, Jeremy

    2015-11-01

    The small Helicon Plasma Experiment (HPX) at the Coast Guard Academy Plasma Lab (CGAPL), continues to progress toward utilizing the reputed high densities (1013 cm-3 and higher) at low pressure (.01 T) [1] of helicons, for eventual high temperature and density diagnostic development in future laboratory investigations. HPX is designed to create repeatedly stable plasmas (~ 20 - 30 ns) induced by an RF frequency in the 10 to 70 MHz range. HPX is constructing RF field corrected Langmuir probe raw data will be collected and used to measure the plasma's density, temperature, and potentially the structure and behavior during experiments. Our 2.5 J YAG laser Thomson Scattering system backed by a 32-channel Data Acquisition (DAQ) system is capable 12 bits of sampling precision at 2 MS/s for HPX plasma property investigations. Progress on the development of the RF coupling system, Helicon Mode development, magnetic coils, and observations from the Thomson Scattering, particle, and electromagnetic scattering diagnostics will be reported. Supported by U.S. DEPS Grant [HEL-JTO] PRWJFY15.

  13. Development of Low Pressure High Density Plasmas on the Helicon Plasma Experiment (HPX)

    NASA Astrophysics Data System (ADS)

    James, Royce; Azzari, Phillip; Crilly, Paul; Duke-Tinson, Omar; Karama, Jackson; Paolino, Richard; Schlank, Carter; Sherman, Justin

    2014-10-01

    The small Helicon Plasma Experiment (HPX) at the Coast Guard Academy Plasma Lab (CGAPL), continues to progress toward utilizing the reputed high densities (10 cm-3 and higher) at low pressure (.01 T) of helicons, for eventual high temperature and density diagnostic development in future laboratory investigations. HPX is designed to create repeatedly stable plasmas induced by an RF frequency in the 10 to 70 MHz range. We employ a 400 to 1000 Gauss electromagnet that promotes energy conservation in the plasma via external energy production in the magnetic field facilitated by decreased inertial effects, in order to reach the Helicon Mode. HPX is completing construction of triple and mach particle probes, magnetic probes, and is designing a single point 300 W Thompson Scattering system backed by a 32-channel Data Acquisition (DAQ) system capable 12 bits of sampling precision at 2 MS/s for HPX plasma property investigations. Progress on the development of the RF coupling system, Helicon Mode development, magnetic coils, and observations from the optical, particle, and electromagnetic scattering diagnostics will be reported. Supported by U.S. DEPS Grant [HEL-JTO] PRWJFY13.

  14. Plasmas and Short-Pulse, High-Intensity Lasers

    NASA Astrophysics Data System (ADS)

    Clark, Thomas

    1999-11-01

    Many of the applications of short-pulse, high-intensity laser systems, including coherent UV and X-ray generation, compact particle accelerators, and non-perturbative nonlinear optics as well as the study of laser-matter interaction physics, require large intensity-interaction length products. In recent years, plasma structures resulting from the hydrodynamic evolution of laser-produced plasma filaments have proven to be attractive media for guiding pulses with peak powers approaching the terawatt level over lengths many times the vacuum Rayleigh range. The hydrodynamics of plasma waveguides have been characterized using time- and space-resolved interferometry measurements of electron density profiles. The laser-driven ionization and heating phase of the plasma filament creation is followed by hot electron driven plasma expansion. Density profiles suitable for optical guiding develop within the first few hundred picoseconds after plasma creation, during which rapid cooling occurs. At longer times the plasma expansion closely follows that of a cylindrical blast wave, with further cooling due to expansion work. The observed guided intensity profiles of end-coupled and tunnel-coupled pulses compare favorably with calculations of the quasi-bound waveguide modes based on the measured electron density profiles. Time- and space-resolved electron density measurements of a laser-driven concentric implosion were also performed. The implosion is the result of the interaction of a second laser pulse with an existing plasma waveguide. The two-pulse absorption and ionization significantly exceed that due to a single pulse of the same total energy. The author would like to acknowledge the significant contributions of Prof. Howard M. Milchberg to the work being presented.

  15. Interaction dynamics of high Reynolds number magnetized plasma flow on the CTIX plasma accelerator

    NASA Astrophysics Data System (ADS)

    Howard, Stephen James

    The Compact Toroid Injection eXperiment, (CTIX), is a coaxial railgun that forms and accelerates magnetized plasma rings called compact toroids (CT's). CTIX consists of a pair of cylindrical coaxial electrodes with the region between them kept at high vacuum (2 m long, 15 cm outer diameter). Hydrogen is typically the dominant constituent of the CT plasma, however helium can also be used. The railgun effect that accelerates the CT can be accounted for by the Lorentz j x B force density created by the power input from a capacitor bank of roughly a Giga-Watt peak. The final velocity of the CT can be as high as 300 km/s, with an acceleration of about 3 billion times Earth's gravity. The compact toroid is able to withstand these forces because of a large internal magnetic field of about 1 Tesla. Understanding the nature of high speed flow of a magnetized plasma has been the primary challenge of this work. In this dissertation we will explore a sequence of fundamental questions regarding the plasma physics of CTIX. First we will go over some new results about the structure and dynamics of the compact toroid's magnetic field, and its electrical resistivity. Then we will present the results from a sequence of key experiments involving reconnection/compression and thermalization of the plasma during interaction of the CT with target magnetic fields of various geometries. Next, we look at the Doppler shift of a spectral line of the He II ion as a measurement of plasma velocity, and to gain insight into the ionization physics of helium in our plasma. These preliminary experiments provide the background for our primary experimental tool for investigating turbulence, a technique called Gas Puff Imaging (GPI) in which a cloud of helium can be used to enhance plasma brightness, allowing plasma density fluctuations to be imaged. We will conclude with an analysis of the images that show coherent density waves, as well as the transition to turbulence during the interaction with a

  16. Excitation and Ionisation dynamics in high-frequency plasmas

    NASA Astrophysics Data System (ADS)

    O'Connell, D.

    2008-07-01

    Non-thermal low temperature plasmas are widely used for technological applications. Increased demands on plasma technology have resulted in the development of various discharge concepts based on different power coupling mechanisms. Despite this, power dissipation mechanisms in these discharges are not yet fully understood. Of particular interest are low pressure radio-frequency (rf) discharges. The limited understanding of these discharges is predominantly due to the complexity of the underlying mechanisms and difficult diagnostic access to important parameters. Optical measurements are a powerful diagnostic tool offering high spatial and temporal resolution. Optical emission spectroscopy (OES) provides non-intrusive access, to the physics of the plasma, with comparatively simple experimental requirements. Improved advances in technology and modern diagnostics now allow deeper insight into fundamental mechanisms. In low pressure rf discharges insight into the electron dynamics within the rf cycle can yield vital information. This requires high temporal resolution on a nano-second time scale. The optical emission from rf discharges exhibits temporal variations within the rf cycle. These variations are particularly strong, in for example capacitively coupled plasmas (CCPs), but also easily observable in inductively coupled plasmas (ICPs), and can be exploited for insight into power dissipation. Interesting kinetic and non-linear coupling effects are revealed in capacitive systems. The electron dynamics exhibits a complex spatio-temporal structure. Excitation and ionisation, and, therefore, plasma sustainment is dominated through directed energetic electrons created through the dynamics of the plasma boundary sheath. In the relatively simple case of an asymmetric capacitively coupled rf plasma the complexity of the power dissipation is exposed and various mode transitions can be clearly observed and investigated. At higher pressure secondary electrons dominate the

  17. Operation of the ORNL High Particle Flux Helicon Plasma Source

    NASA Astrophysics Data System (ADS)

    Goulding, R. H.; Biewer, T. M.; Caughman, J. B. O.; Chen, G. C.; Owen, L. W.; Sparks, D. O.

    2011-12-01

    A high power, high particle flux rf-based helicon plasma source has been constructed at ORNL and operated at power levels up to 30 kW. High-density hydrogen and helium plasmas have been produced. The source has been designed as the basis for a linear plasma materials interaction (PMI) test facility that will generate particle fluxes Γp1023 m-3 s-1, and utilize additional ion and electron cyclotron heating to produce high parallel (to the magnetic field) heat fluxes of ˜10 MW/m2. An rf-based source for PMI research is of interest because high plasma densities are generated with no internal electrodes, allowing true steady state operation with minimal impurity generation. The ORNL helicon source has a diameter of 15 cm and to-date has operated at a frequency f = 13.56 MHz, with magnetic field strength |B| in the antenna region up to ˜0.15 T. Maximum densities of 3×1019 m-3 in He and 2.5×1019 m-3 in H have been achieved. Radial density profiles have been seen to be dependent on the axial |B| profile.

  18. Counter-facing plasma focus system as a repetitive and/or long-pulse high energy density plasma source

    NASA Astrophysics Data System (ADS)

    Aoyama, Yutaka; Nakajima, Mitsuo; Horioka, Kazuhiko

    2009-11-01

    A plasma focus system composed of a pair of counter-facing coaxial plasma guns is proposed as a long-pulse and/or repetitive high energy density plasma source. A proof-of-concept experiment demonstrated that with an assist of breakdown and outer electrode connections, current sheets evolved into a configuration for stable plasma confinement at the center of the electrodes. The current sheets could successively compress and confine the high energy density plasma every half period of the discharge current, enabling highly repetitive light emissions in extreme ultraviolet region with time durations in at least ten microseconds.

  19. Low energy, high power hydrogen neutral beam for plasma heating

    NASA Astrophysics Data System (ADS)

    Deichuli, P.; Davydenko, V.; Ivanov, A.; Korepanov, S.; Mishagin, V.; Smirnov, A.; Sorokin, A.; Stupishin, N.

    2015-11-01

    A high power, relatively low energy neutral beam injector was developed to upgrade of the neutral beam system of the gas dynamic trap device and C2-U experiment. The ion source of the injector produces a proton beam with the particle energy of 15 keV, current of up to 175 A, and pulse duration of a few milliseconds. The plasma emitter of the ion source is produced by superimposing highly ionized plasma jets from an array of four arc-discharge plasma generators. A multipole magnetic field produced with permanent magnets at the periphery of the plasma box is used to increase the efficiency and improve the uniformity of the plasma emitter. Multi-slit grids with 48% transparency are fabricated from bronze plates, which are spherically shaped to provide geometrical beam focusing. The focal length of the Ion Optical System (IOS) is 3.5 m and the initial beam diameter is 34 cm. The IOS geometry and grid potentials were optimized numerically to ensure accurate beam formation. The measured angular divergences of the beam are ±0.01 rad parallel to the slits and ±0.03 rad in the transverse direction.

  20. Low energy, high power hydrogen neutral beam for plasma heating.

    PubMed

    Deichuli, P; Davydenko, V; Ivanov, A; Korepanov, S; Mishagin, V; Smirnov, A; Sorokin, A; Stupishin, N

    2015-11-01

    A high power, relatively low energy neutral beam injector was developed to upgrade of the neutral beam system of the gas dynamic trap device and C2-U experiment. The ion source of the injector produces a proton beam with the particle energy of 15 keV, current of up to 175 A, and pulse duration of a few milliseconds. The plasma emitter of the ion source is produced by superimposing highly ionized plasma jets from an array of four arc-discharge plasma generators. A multipole magnetic field produced with permanent magnets at the periphery of the plasma box is used to increase the efficiency and improve the uniformity of the plasma emitter. Multi-slit grids with 48% transparency are fabricated from bronze plates, which are spherically shaped to provide geometrical beam focusing. The focal length of the Ion Optical System (IOS) is 3.5 m and the initial beam diameter is 34 cm. The IOS geometry and grid potentials were optimized numerically to ensure accurate beam formation. The measured angular divergences of the beam are ±0.01 rad parallel to the slits and ±0.03 rad in the transverse direction. PMID:26628137

  1. Low energy, high power hydrogen neutral beam for plasma heating

    SciTech Connect

    Deichuli, P.; Davydenko, V.; Ivanov, A. Mishagin, V.; Sorokin, A.; Stupishin, N.; Korepanov, S.; Smirnov, A.

    2015-11-15

    A high power, relatively low energy neutral beam injector was developed to upgrade of the neutral beam system of the gas dynamic trap device and C2-U experiment. The ion source of the injector produces a proton beam with the particle energy of 15 keV, current of up to 175 A, and pulse duration of a few milliseconds. The plasma emitter of the ion source is produced by superimposing highly ionized plasma jets from an array of four arc-discharge plasma generators. A multipole magnetic field produced with permanent magnets at the periphery of the plasma box is used to increase the efficiency and improve the uniformity of the plasma emitter. Multi-slit grids with 48% transparency are fabricated from bronze plates, which are spherically shaped to provide geometrical beam focusing. The focal length of the Ion Optical System (IOS) is 3.5 m and the initial beam diameter is 34 cm. The IOS geometry and grid potentials were optimized numerically to ensure accurate beam formation. The measured angular divergences of the beam are ±0.01 rad parallel to the slits and ±0.03 rad in the transverse direction.

  2. Isotopic and Hydrogeochemical Studies on Abnormally High Ammonium of Natural Origin in A Coastal Aquifer-aquitard System

    NASA Astrophysics Data System (ADS)

    Wang, Y.; Jiao, J. J.; Cherry, J.

    2010-12-01

    Excessive nitrogen concentration in water bodies is regarded as an environmental contamination because of its possible harm to human bodies and significant ecological effects. Previous studies commonly concerned on elevated nitrogen in water of anthropogenic origins, such as agricultural, domestic, sewage and industrial discharges, because people realize that it is necessary to manage negative influences of human being to the natural environment. Understanding contamination sources of nitrogen is crucial for both waste discharge management and pollutants cleanup. This study was aimed to 1) understand the spatial distribution of abnormally high ammonium groundwater in the Quaternary basalt aquifer in the Pearl River Delta (PRD), China; 2) to distinguish sources of recharge to the basalt aquifer; and 3) to identify the origin of the ammonium in the aquitard and aquifer system. Total 40 boreholes were drilled, and approximately 1000 deposit samples from the aquitard and over 200 groundwater samples from the Quaternary basalt aquifer were collected. A cluster of 7 piezometers was installed in Minzhong Town to study the hydraulic relationships between the aquitard and the basalt aquifer. The results demonstrated that the greater groundwater ammonium concentrations were preserved in the aquifer buried deeper. The ammonium concentration up to 390 mg/L was observed in the basalt sand and gravel Pleistocene aquifer of 20-50m deep, and this is the greatest concentration ever reported for natural groundwater globally. The Quaternary aquitard, which contained abundant sedimentary organic matter and was mainly composed of silt and clay, provided a strict anaerobic environment for sedimentary organic matter mineralization and ammonium preservation. Ammonium concentrations in the aquifer were predominantly controlled by the aquitard ammonium content. This naturally occurring abnormally high ammonium in the Quaternary sediments is areally extensive (over 1600 km2). Great

  3. Magnetized plasma flow injection into tokamak and high-beta compact torus plasmas

    NASA Astrophysics Data System (ADS)

    Matsunaga, Hiroyuki; Komoriya, Yuuki; Tazawa, Hiroyasu; Asai, Tomohiko; Takahashi, Tsutomu; Steinhauer, Loren; Itagaki, Hirotomo; Onchi, Takumi; Hirose, Akira

    2010-11-01

    As an application of a magnetized coaxial plasma gun (MCPG), magnetic helicity injection via injection of a highly elongated compact torus (magnetized plasma flow: MPF) has been conducted on both tokamak and field-reversed configuration (FRC) plasmas. The injected plasmoid has significant amounts of helicity and particle contents and has been proposed as a fueling and a current drive method for various torus systems. In the FRC, MPF is expected to generate partially spherical tokamak like FRC equilibrium by injecting a significant amount of magnetic helicity. As a circumstantial evidence of the modified equilibrium, suppressed rotational instability with toroidal mode number n = 2. MPF injection experiments have also been applied to the STOR-M tokamak as a start-up and current drive method. Differences in the responses of targets especially relation with beta value and the self-organization feature will be studied.

  4. Internal Kink Mode Dynamics in High-beta NSTX Plasmas

    SciTech Connect

    J.E. Menard; R.E. Bell; E.D. Fredrickson; D.A. Gates; S.M. Kaye; B.P. LeBlanc; S.S. Medley; W. Park; S.A. Sabbagh; A. Sontag; D. Stutman; K. Tritz; W. Zhu; the NSTX Research Team

    2004-12-22

    Saturated internal kink modes have been observed in many of the highest toroidal {beta} discharges of the National Spherical Torus Experiment (NSTX). These modes often cause rotation flattening in the plasma core, can degrade energy confinement, and in some cases contribute to the complete loss of plasma angular momentum and stored energy. Characteristics of the modes are measured using soft X-ray, kinetic profile, and magnetic diagnostics. Toroidal flows approaching Alfvenic speeds, island pressure peaking, and enhanced viscous and diamagnetic effects associated with high-{beta} may contribute to mode nonlinear stabilization. These saturation mechanisms are investigated for NSTX parameters and compared to experimental data.

  5. A HIGH REPETITION PLASMA MIRROR FOR STAGED ELECTRON ACCELERATION

    SciTech Connect

    Sokollik, Thomas; Shiraishi, Satomi; Osterhoff, Jens; Evans, Eugene; Gonsalves, Anthony; Nakamura, Kei; vanTilborg, Jeroen; Lin, Chen; Toth, Csaba; Leemans, Wim

    2011-07-22

    In order to build a compact, staged laser plasma accelerator the in-coupling of the laser beam to the different stages represents one of the key issues. To limit the spatial foot print and thus to realize a high overall acceleration gradient, a concept has to be found which realizes this in-coupling within a few centimeters. We present experiments on a tape-drive based plasma mirror which could be used to reflect the focused laser beam into the acceleration stage.

  6. Forbidden line emission from highly ionized atoms in tokamak plasmas

    NASA Technical Reports Server (NTRS)

    Feldman, U.; Doschek, G. A.; Bhatia, A. K.

    1982-01-01

    Considerable interest in the observation of forbidden spectral lines from highly ionized atoms in tokamak plasmas is related to the significance of such observations for plasma diagnostic applications. Atomic data for the elements Ti Cr, Mn, Fe, Ni, and Kr have been published by Feldman et al. (1980) and Bhatia et al. (1980). The present investigation is concerned with collisional excitation rate coefficients and radiative decay rates, which are interpolated for ions of elements between calcium, and krypton and for levels of the 2s2 2pk, 2s 2p(k+1), and 2p(k+2) configurations, and for the O I, N I, C I, B I, and Be I isoelectronic sequences. The provided interpolated atomic data can be employed to calculate level populations and relative line intensities for ions of the considered sequences, taking into account levels of the stated configurations. Important plasma diagnostic information provided by the forbidden lines includes the ion temperature

  7. Transport studies in high-performance field reversed configuration plasmas

    NASA Astrophysics Data System (ADS)

    Gupta, S.; Barnes, D. C.; Dettrick, S. A.; Trask, E.; Tuszewski, M.; Deng, B. H.; Gota, H.; Gupta, D.; Hubbard, K.; Korepanov, S.; Thompson, M. C.; Zhai, K.; Tajima, T.

    2016-05-01

    A significant improvement of field reversed configuration (FRC) lifetime and plasma confinement times in the C-2 plasma, called High Performance FRC regime, has been observed with neutral beam injection (NBI), improved edge stability, and better wall conditioning [Binderbauer et al., Phys. Plasmas 22, 056110 (2015)]. A Quasi-1D (Q1D) fluid transport code has been developed and employed to carry out transport analysis of such C-2 plasma conditions. The Q1D code is coupled to a Monte-Carlo code to incorporate the effect of fast ions, due to NBI, on the background FRC plasma. Numerically, the Q1D transport behavior with enhanced transport coefficients (but with otherwise classical parametric dependencies) such as 5 times classical resistive diffusion, classical thermal ion conductivity, 20 times classical electron thermal conductivity, and classical fast ion behavior fit with the experimentally measured time evolution of the excluded flux radius, line-integrated density, and electron/ion temperature. The numerical study shows near sustainment of poloidal flux for nearly 1 ms in the presence of NBI.

  8. High energy components and collective modes in thermonuclear plasmas

    SciTech Connect

    Coppi, B.; Cowley, S.; Detragiache, P.; Kulsrud, R.; Pegoraro, F.

    1986-02-01

    The theory of a class of collective modes of a thermonuclear magnetically confined plasma, with frequencies in the range of the ion cyclotron frequency and of its harmonics, is presented. These modes can be excited by their resonant cyclotron interaction with a plasma component of relatively high energy particles characterized by a strongly anisotropic distribution in velocity space. Normal modes that are spatially localized by the inhomogeneity of the plasma density are found. This ensures that the energy gained by their resonant interaction is not convected away. The mode spatial localization can be significantly altered by the magnetic field inhomogeneity for a given class of plasma density profiles. Special attention is devoted to the case of a spin polarized plasma, where the charged products of fusion reactions are anisotropically distributed. We show that for the mode of polarization that enhances nuclear reaction rates the tritium will be rapidly depolarized to toroidal configurations with relatively mild gradients of the confining magnetic field. 18 refs., 9 figs.

  9. Diagnostic accuracy of myocardial deformation indices for detecting high risk coronary artery disease in patients without regional wall motion abnormality

    PubMed Central

    Rostamzadeh, Alireza; Shojaeifard, Maryam; Rezaei, Yousef; Dehghan, Kasra

    2015-01-01

    Background: The prediction of coronary artery disease (CAD) by conventional echocardiographic measurements is principally based on the estimation of ejection fraction and regional wall motion abnormality (RWMA). This study aimed to determine whether strain echocardiography of left ventricle measured by velocity vector imaging (VVI) method could detect patients with a high-risk CAD. Methods: In a prospective study, a total of 119 consecutive patients who were assessed for eligibility were categorized into three groups: (1) without CAD as normal (n=59), (2) 1- or 2-vessel disease as low-risk (n=29), and (3) left main and/or 3-vessel disease as high-risk (n=31). The peaks of systolic strain and strain rate from 18 curves of apical views were averaged as global longitudinal strain and strain rate (GLS and GLSR), respectively; the 6 systolic peaks of strain and strain rate at base- and mid-ventricular of short axis views were averaged as mean radial strain rate (MRSR). Results: GLS, GLSR, and basal MRSR of left ventricle were significantly lower in the high-risk group (P=0.047, P=0.004 and P=0.030, respectively). Receiver operating characteristics curve showed that the optimal values of GLS, GLSR, and basal MRSR for detecting the severe CAD were -17%, -1 s-1, and 1.45 s-1 with the sensitivities of 77%, 71%, and 71% and the specificities of 63%, 67%, and 62%, respectively. Conclusion: Decrements in the GLS, GLSR, and basal MRSR of the left ventricle can detect the high-risk CAD cases among patients without RWMA at rest. PMID:26309603

  10. Plasma-polymerized methyl methacrylate via intense and highly energetic atmospheric pressure micro-plasma for bio-medical applications

    NASA Astrophysics Data System (ADS)

    Park, Choon-Sang; Ballato, John; Kim, Sung-O.; Clemson University Team

    2013-09-01

    Poly (methyl methacrylate), PMMA, has been widely used as a biocompatible material in bone cement, dental fillings, and many other bio-related applications. Vacuum plasmas and radio frequency (RF) atmospheric plasmas are the most common methods for depositing plasma-derived thin films and nanoparticles. However, the necessary equipment is difficult to operate and maintain as well as being large and expensive. Here, we report the use of a novel intense and highly energetic atmospheric pressure plasma jet array using direct plasma jet-to-jet coupling effects to deposit high quality plasma-polymerized MMA (PPMMA) for bio-medical applications. The newly proposed atmospheric pressure micro-plasma jet array device can generate the intense plasma mode with a strong plasma emission and high plasma particle energy. PPMMA was successfully deposited on a variety of substrates and characterized by SEM, AFM, and FT-IR. The micro-plasma jet is obtained at a sinusoidal voltage with a peak value of 30 kV and frequency of 35 kHz. Argon gas was employed as the discharge gas for plasma generation and its flow rate was in the range of 2230 sccm, Methyl methacrylate (MMA) monomer was vaporized by means of a glass bubbler which was supplied by argon gas with flow rates in the range of 268 sccm from room temperature to 400°C. The deposited PPMMA thin films were flexible, transparent, thin, and strong on metal substrates.

  11. Hot, dense, millimeter-scale, high-Z plasmas for laser-plasma interactions studies.

    PubMed

    Failor, B H; Fernandez, J C; Wilde, B H; Osterheld, A L; Cobble, J A; Gobby, P L

    1999-05-01

    We have designed and produced hot, millimeter-scale, high-Z plasmas of interest for National Ignition Facility hohlraum target design. Using a high-Z gas fill produces electron temperatures in the 3.5-6-keV range, the highest temperatures measured to date for high-density (10(21) e/cm(3)) laser-heated plasmas, and much higher than the 3 keV found for low-Z (neopentane) fills. These measurements are in good agreement with the target design calculations, and the L-shell spectroscopic approach used to estimate the electron temperature has certain advantages over traditional K-shell approaches. PMID:11969590

  12. A Two Step Plasma Conditioning Scheme for High Current Plasma Implosions

    NASA Astrophysics Data System (ADS)

    Choi, P.; Zakharov, S. V.

    2006-01-01

    We consider the effect of using a limited energy current pre-pulse to first heat and evaporate a solid material in wire or cylindrical foil geometry, and second to allow the material to expand until a suitable characteristic scale dimension, like the skin depth, before the application of the main high current pulse for compression and heating. In this way, due to the large-scale density distribution formed during plasma expansion in the preparation phase, the short-wavelength instabilities may be suppressed. This idea is confirmed by 2-D RMHD simulations of the implosion of plasma from exploding a 13.6μm diameter tungsten wire evaporated with a low-energy pre-pulse, free expansion of the wire plasma until a necessary radius and subsequent implosion by a main pulse. The higher resistance against short-wavelength instabilities results in a better quality compression and a higher energy density plasma structure. For implosion of a thin foil liner, the idea of two step implosion is considered by comparison of 2-D RMHD simulations of the implosion of a 1.5μm copper foil at 18MA current amplitude in two cases: with and without pre-pulse. The fastest short-wavelength RT modes associated with high aspect ratio are suppressed due to a finite density gradient at the main pulse. The criteria for the optimum pre-pulse are examined to improve the radiation characteristics for given pulsed power conditions.

  13. Chromosome 13q deletion and IgH abnormalities may be both masked by near-tetraploidy in a high proportion of multiple myeloma patients: a combined morphology and I-FISH analysis.

    PubMed

    Koren-Michowitz, Maya; Hardan, Izhar; Berghoff, Janina; Yshoev, Galina; Amariglio, Ninette; Rechavi, Gideon; Nagler, Arnon; Trakhtenbrot, Luba

    2007-10-01

    Ploidy status and chromosomal aberrations involving chromosome 13q and the immunoglobulin heavy chain locus (IgH) are important prognostic features in multiple myeloma (MM). However, conventional cytogenetic studies are often not reveling and determination of plasma cells (PC) ploidy status in MM is technically difficult. We have used a combined cell morphology and interphase FISH (I-FISH) analysis in 184 consecutive BM samples from 136 MM patients for the diagnosis of chromosome 13q deletion [del (13q)] and IgH abnormalities. We have found a high prevalence (37%) of near-tetraploid (NT) PC in the BM samples studied. NT status of PC was verified with DNA index (DI) measurements. del (13q) was found in 69% and a total absence of one IgH copy (loss of IgH) in 20% of NT samples. We have shown that the presence of del (13q) and loss of IgH can be masked in NT cases: in 12 NT samples originally identified as normal for del (13q) the abnormality was obscured in the majority of plasma cells due to the presence of NT. Similarly, loss of IgH was masked in four samples with a large population of NT cells. Moreover, in one case the appearance of a 100% tetraploidy during disease progression masked the presence of del (13q), originally present, and could therefore falsely appear as disappearance of this prognostic marker. In conclusion, we have shown that a combination of three abnormalities, i.e., del (13q), loss of IgH and NT, all of potential prognostic significance, can be overlooked unless NT is specifically searched for and ruled out. Therefore, we suggest that a search for NT should be added to the routine BM assessment in MM patients. PMID:17590504

  14. Abnormal functional specialization within medial prefrontal cortex in high-functioning autism: a multi-voxel similarity analysis

    PubMed Central

    Meuwese, Julia D.I.; Towgood, Karren J.; Frith, Christopher D.; Burgess, Paul W.

    2009-01-01

    Multi-voxel pattern analyses have proved successful in ‘decoding’ mental states from fMRI data, but have not been used to examine brain differences associated with atypical populations. We investigated a group of 16 (14 males) high-functioning participants with autism spectrum disorder (ASD) and 16 non-autistic control participants (12 males) performing two tasks (spatial/verbal) previously shown to activate medial rostral prefrontal cortex (mrPFC). Each task manipulated: (i) attention towards perceptual versus self-generated information and (ii) reflection on another person's mental state (‘mentalizing'versus ‘non-mentalizing’) in a 2 × 2 design. Behavioral performance and group-level fMRI results were similar between groups. However, multi-voxel similarity analyses revealed strong differences. In control participants, the spatial distribution of activity generalized significantly between task contexts (spatial/verbal) when examining the same function (attention/mentalizing) but not when comparing different functions. This pattern was disrupted in the ASD group, indicating abnormal functional specialization within mrPFC, and demonstrating the applicability of multi-voxel pattern analysis to investigations of atypical populations. PMID:19174370

  15. Abnormal functional specialization within medial prefrontal cortex in high-functioning autism: a multi-voxel similarity analysis.

    PubMed

    Gilbert, Sam J; Meuwese, Julia D I; Towgood, Karren J; Frith, Christopher D; Burgess, Paul W

    2009-04-01

    Multi-voxel pattern analyses have proved successful in 'decoding' mental states from fMRI data, but have not been used to examine brain differences associated with atypical populations. We investigated a group of 16 (14 males) high-functioning participants with autism spectrum disorder (ASD) and 16 non-autistic control participants (12 males) performing two tasks (spatial/verbal) previously shown to activate medial rostral prefrontal cortex (mrPFC). Each task manipulated: (i) attention towards perceptual versus self-generated information and (ii) reflection on another person's mental state ('mentalizing'versus 'non-mentalizing') in a 2 x 2 design. Behavioral performance and group-level fMRI results were similar between groups. However, multi-voxel similarity analyses revealed strong differences. In control participants, the spatial distribution of activity generalized significantly between task contexts (spatial/verbal) when examining the same function (attention/mentalizing) but not when comparing different functions. This pattern was disrupted in the ASD group, indicating abnormal functional specialization within mrPFC, and demonstrating the applicability of multi-voxel pattern analysis to investigations of atypical populations. PMID:19174370

  16. High Power Light Gas Helicon Plasma Source For VASMIR

    NASA Technical Reports Server (NTRS)

    Squire, J. P.; Chang-Diaz, F. R.; Glover, T. W.; Jacobson, V. T.; McCaskill, G. E.; Winter, D. S.; Baity, F. W.; Carter, M. D.; Goulding, R. H.

    2004-01-01

    The VASIMR space propulsion development effort relies on a high power (greater than 10kW) helicon source to produce a dense flowing plasma (H, D and He) target for ion cyclotron resonance (ICR) acceleration of the ions. Subsequent expansion in an expanding magnetic field (magnetic nozzle) converts ion lunetic energy to directed momentum. This plasma source must have critical features to enable an effective propulsion device. First, it must ionize most of the input neutral flux of gas, thus producing a plasma stream with a high degree of ionization for application of ICR power. This avoids propellant waste and potential power losses due to charge exchange. Next, the plasma stream must flow into a region of high magnetic field (approximately 0.5 T) for efficient ICR acceleration. Third, the ratio of input power to plasma flux must be low, providing an energy per ion-electron pair approaching 100 eV. Lastly, the source must be robust and capable of very long life-times (years). In our helicon experiment (VX-10) we have measured a ratio of input gas to plasma flux near 100%. The plasma flows from the helicon region (B approximately 0.1 T) into a region with a peak magnetic field of 0.8 T. The energy input per ion-electron pair has been measured at 300 plus or minus 100 eV. Recent results at Oak Ridge National Laboratory (ORNL) show an enhanced efficiency mode of operation with a high power density, over 5 kW in a 5 cm diameter tube. Our helicon is presently 9 cm in diameter and operates up to 3.5 kW of input power. An upgrade to a power level of 10 kW is underway. Much of our recent work has been with a Boswell double-saddle antenna design. We are also converting the antenna design to a helical type. With these modifications, we anticipate an improvement in the ionization efficiency. This paper presents the results from scaling the helicon in the VX-10 device from 3.5 to 10 kW. We also compare the operation with a double-saddle to a helical antenna design. Finally, we

  17. Relatively high plasma density in low pressure inductive discharges

    SciTech Connect

    Kang, Hyun-Ju; Kim, Yu-Sin; Chung, Chin-Wook

    2015-09-15

    Electron energy probability functions (EEPFs) were measured in a low pressure argon inductive discharge. As radio frequency (RF) power increases, discharge mode is changed from E-mode (capacitively coupled) to H-mode (inductively coupled) and the EEPFs evolve from a bi-Maxwellian distribution to a Maxwellian distribution. It is found that the plasma densities at low RF powers (<30 W) are much higher than the density predicted from the slope of the densities at high powers. Because high portion of high energy electrons of the bi-Maxwellian distribution lowers the collisional energy loss and low electron temperature of low energy electrons reduces particle loss rate at low powers. Therefore, the energy loss of plasma decreases and electron densities become higher at low powers.

  18. Transient Plasma Photonic Crystals for High-Power Lasers.

    PubMed

    Lehmann, G; Spatschek, K H

    2016-06-01

    A new type of transient photonic crystals for high-power lasers is presented. The crystal is produced by counterpropagating laser beams in plasma. Trapped electrons and electrically forced ions generate a strong density grating. The lifetime of the transient photonic crystal is determined by the ballistic motion of ions. The robustness of the photonic crystal allows one to manipulate high-intensity laser pulses. The scheme of the crystal is analyzed here by 1D Vlasov simulations. Reflection or transmission of high-power laser pulses are predicted by particle-in-cell simulations. It is shown that a transient plasma photonic crystal may act as a tunable mirror for intense laser pulses. Generalizations to 2D and 3D configurations are possible. PMID:27314721

  19. High temperature plasma in beta Lyrae, observed from Copernicus

    NASA Technical Reports Server (NTRS)

    Kondo, Y.; Hack, M.; Hutchings, J. B.; Mccluskey, G. E., Jr.; Plavec, M.; Polidan, R. S.

    1975-01-01

    High-resolution UV spectrophotometry of the complex close binary system beta Lyrae was performed with a telescope spectrometer on board Copernicus. Observations were made at phases 0.0, 0.25, 0.5, and 0.75 with resolutions of 0.2 A (far-UV) and 0.4 A (mid-UV). The far-UV spectrum is completely dominated by emission lines indicating the existence of a high-temperature plasma in this binary. The spectrum of this object is unlike that of any other object observed from Copernicus. It is believed that this high-temperature plasma results from dynamic mass transfer taking place in the binary. The current results are compared with OAO-2 observations and other observational results. The possibility that the secondary component is a collapsed object is also discussed; the Copernicus observations are consistent with the hypothesis that the spectroscopically invisible secondary component is a black hole.

  20. Transient Plasma Photonic Crystals for High-Power Lasers

    NASA Astrophysics Data System (ADS)

    Lehmann, G.; Spatschek, K. H.

    2016-06-01

    A new type of transient photonic crystals for high-power lasers is presented. The crystal is produced by counterpropagating laser beams in plasma. Trapped electrons and electrically forced ions generate a strong density grating. The lifetime of the transient photonic crystal is determined by the ballistic motion of ions. The robustness of the photonic crystal allows one to manipulate high-intensity laser pulses. The scheme of the crystal is analyzed here by 1D Vlasov simulations. Reflection or transmission of high-power laser pulses are predicted by particle-in-cell simulations. It is shown that a transient plasma photonic crystal may act as a tunable mirror for intense laser pulses. Generalizations to 2D and 3D configurations are possible.

  1. Spectroscopic measurements of high frequency plasma in supercritical carbon dioxide

    SciTech Connect

    Maehara, T.; Mukasa, S.; Takemori, T.; Watanabe, T.; Kurokawa, K.; Toyota, H.; Nomura, S.; Kawashima, A.; Iwamae, A.

    2009-03-15

    Spectroscopic measurements of high frequency (hf) plasma were performed under high pressure conditions (5 and 7 MPa) and supercritical (sc) CO{sub 2} conditions (8-20 MPa). Temperature evaluated from C{sub 2} Swan bands (d {sup 3}{pi}{sub g}{yields}a {sup 3}{pi}{sub u}) increased from 3600 to 4600 K with an increase in pressure. The first observation of broadening and shifting of the O I line profile (3p {sup 5} P{sub 3,2,1}{yields}3s {sup 5} S{sub 2}{sup 0}) of hf plasma under sc CO{sub 2} conditions was carried out. However, the origin of broadening and the shifting cannot be understood because the present theory explaining them is not valid for such high pressure conditions.

  2. Universal attractor in a highly occupied non-Abelian plasma

    NASA Astrophysics Data System (ADS)

    Berges, J.; Boguslavski, K.; Schlichting, S.; Venugopalan, R.

    2014-06-01

    We study the thermalization process in highly occupied non-Abelian plasmas at weak coupling. The nonequilibrium dynamics of such systems is classical in nature and can be simulated with real-time lattice gauge theory techniques. We provide a detailed discussion of this framework and elaborate on the results reported in J. Berges, K. Boguslavski, S. Schlichting, and R. Venugopalan, Phys. Rev. D 89, 074011 (2014), 10.1103/PhysRevD.89.074011 along with novel findings. We demonstrate the emergence of universal attractor solutions, which govern the nonequilibrium evolution on large time scales both for nonexpanding and expanding non-Abelian plasmas. The turbulent attractor for a nonexpanding plasma drives the system close to thermal equilibrium on a time scale t ˜Q-1αs-7/4. The attractor solution for an expanding non-Abelian plasma leads to a strongly interacting albeit highly anisotropic system at the transition to the low-occupancy or quantum regime. This evolution in the classical regime is, within the uncertainties of our simulations, consistent with the "bottom up" thermalization scenario [R. Baier, A. H. Mueller, D. Schiff, and D. T. Son, Phys. Lett. B 502, 51 (2001), 10.1016/S0370-2693(01)00191-5]. While the focus of this paper is to understand the nonequilibrium dynamics in weak coupling asymptotics, we also discuss the relevance of our results for larger couplings in the early time dynamics of heavy ion collision experiments.

  3. Plasma relaxation mechanics of pulsed high power microwave surface flashover

    SciTech Connect

    Beeson, S.; Dickens, J.; Neuber, A.

    2013-09-15

    Microwave transmission and reflection characteristics of pulsed radio frequency field generated plasmas are elucidated for air, N{sub 2}, and He environments under pressure conditions ranging from 10 to 600 torr. The pulsed, low temperature plasma is generated along the atmospheric side of the dielectric boundary between the source (under vacuum) and the radiating environment with a thickness on the order of 5 mm and a cross sectional area just smaller than that of the waveguide. Utilizing custom multi-standard waveguide couplers and a continuous low power probing source, the scattering parameters were measured before, during, and after the high power microwave pulse with emphasis on the latter. From these scattering parameters, temporal electron density estimations (specifically the longitudinal integral of the density) were calculated using a 1D plane wave-excited model for analysis of the relaxation processes associated. These relaxation characteristics ultimately determine the maximum repetition rate for many pulsed electric field applications and thus are applicable to a much larger scope in the plasma community than just those related to high power microwaves. This manuscript discusses the diagnostic setup for acquiring the power measurements along with a detailed description of the kinematic and chemical behavior of the plasma as it decays down to its undisturbed state under various gas type and pressure conditions.

  4. The Challenges of High-Power Plasma Propulsion

    NASA Astrophysics Data System (ADS)

    Chang-Diaz, Franklin

    2004-11-01

    Our future space explorers face many challenges but three loom high above the rest: physiological debilitation, radiation and psychological stress. Counter-measures are presently being considered to ameliorate these difficulties; however, two new developments are required: abundant space power and advanced propulsion. Also, electric propulsion, long relegated to low-power thrusters, has been reinvigorated by interest in multi-megawatt plasma propulsion. One rapidly evolving concept, the Variable Specific Impulse Magnetoplasma Rocket (VASIMR,) borrows heavily from magnetic fusion research, particularly on RF plasma generation and heating in mirror-like geometries. Axial momentum is obtained by expansion of the plasma in a magnetic nozzle. The configuration could enable thrust and specific impulse variation, at constant power, allowing in-flight mission performance optimization. VASIMR technology, and similar others, could be validated, in the near term, on the International Space Station, where they can benefit from a container-less environment and virtually infinite vacuum. The experiments could also help re-boost the orbital facility. This paper describes the advantages and operational motivation for high-power plasma rockets, illustrated through the VASIMR research effort.

  5. High Performance Plasmas on the National Spherical Torus Experiment

    SciTech Connect

    D.A. Gates; M.G. Bell; R.E. Bell; J. Bialek; T. Bigelow; M. Bitter; P. Bonoli; D. Darrow; P. Efthimion; J. Ferron; E. Fredrickson; L. Grisham; J. Hosea; D. Johnson; R. Kaita; S. Kaye; S. Kubota; H. Kugel; B. LeBlanc; R. Maingi; J. Manickam; T.K. Mau; R.J. Maqueda; E. Mazzucato; J. Menard; D. Mueller; B. Nelson; N. Nishino; M. Ono; F. Paoletti; S. Paul; Y-K.M. Peng; C.K. Phillips; R. Raman; P. Ryan; S.A. Sabbagh; M. Schaffer; C.H. Skinner; D. Stutman; D. Swain; E. Synakowski; Y. Takase; J. Wilgen; J.R. Wilson; W. Zhu; S. Zweben; A. Bers; M. Carter; B. Deng; C. Domier; E. Doyle; M. Finkenthal; K. Hill; T. Jarboe; S. Jardin; H. Ji; L. Lao; K.C. Lee; N. Luhmann; R. Majeski; H. Park; T. Peebles; R.I. Pinsker; G. Porter; A. Ram; M. Rensink; T. Rognlien; D. Stotler; B. Stratton; G. Taylor; W. Wampler; G.A. Wurden; X.Q. Xu; L. Zeng; and the NSTX Team

    2001-07-10

    The National Spherical Torus Experiment (NSTX) has produced toroidal plasmas at low aspect ratio (A = R/a = 0.86 m/0.68 m approximately equal to 1.3, where R is the major radius and a is the minor radius of the torus) with plasma currents of 1.4 MA. The rapid development of the machine has led to very exciting physics results during the first full year of physics operation. Pulse lengths in excess of 0.5 sec have been obtained with inductive current drive. Up to 4 MW of High Harmonic Fast Wave (HHFW) heating power has been applied with 6 MW planned. Using only 2 MW of HHFW heating power clear evidence of electron heating is seen with HHFW, as observed by the multi-point Thomson scattering diagnostic. A noninductive current drive concept known as Coaxial Helicity Injection (CHI) has driven 260 kA of toroidal current. Neutral-beam heating power of 5 MW has been injected. Plasmas with beta toroidal (= 2 mu(subscript ''0'')

    /B(superscript ''2'') = a measure of magnetic confinement efficiency ) of 22% have been achieved, as calculated using the EFIT equilibrium reconstruction code. Beta-limiting phenomena have been observed, and the maximum beta toroidal scales with I(subscript ''p'')/aB(subscript ''t''). High frequency (>MHz) magnetic fluctuations have been observed. High-confinement mode plasmas are observed with confinement times of >100 msec. Beam-heated plasmas show energy confinement times in excess of those predicted by empirical scaling expressions. Ion temperatures in excess of 2.0 keV have been measured, and power balance suggests that the power loss from the ions to the electrons may exceed the calculated classical input power to the ions.

  6. Versatile high rate plasma deposition and processing with very high frequency excitation

    SciTech Connect

    Heintze, M.

    1997-07-01

    The interest in plasma deposition using very high frequency (VHF) excitation arose after the preparation of a-Si:H at high growth rates was demonstrated. Subsequently the improved process flexibility and the control of material properties offered by the variation of the plasma excitation frequency was recognized. The preparation of amorphous and microcrystalline thin films in a VHF-plasma is described. The increased growth rates have been attributed to an enhancement of film precursor formation at VHF, to the decreased sheath thickness as well as to an enhancement of the surface reactivity by positive ions. Plasma diagnostic investigations show that the parameters mainly affected by the excitation frequency are the ion flux to the electrodes as well as the sheaths potentials and widths, rather than the plasma density. 55 refs., 13 figs.

  7. Helicon waves in uniform plasmas. II. High m numbers

    NASA Astrophysics Data System (ADS)

    Stenzel, R. L.; Urrutia, J. M.

    2015-09-01

    Helicons are whistler modes with azimuthal wave numbers. They have been studied in solids and plasmas where boundaries play a role. The present work shows that very similar modes exist in unbounded gaseous plasmas. Instead of boundaries, the antenna properties determine the topology of the wave packets. The simplest antenna is a magnetic loop which excites m = 0 or m = 1 helicons depending on whether the dipole moment is aligned parallel or perpendicular to the ambient background magnetic field B0. While these low order helicons have been described by J. M. Urrutia and R. L. Stenzel ["Helicon modes in uniform plasmas. I. Low m modes," Phys. Plasmas 22, 092111 (2015)], the present work focuses on high order modes up to m = 8. These are excited by antenna arrays forming magnetic multipoles. Their wave magnetic field has been measured in space and time in a large and uniform laboratory plasma free of boundary effects. The observed wave topology exhibits m pairs of unique field line spirals which may have inspired the name "helicon" to this mode. All field lines converge into these nested spirals which propagate like corkscrews along B0. The field lines near the axis of helicons are perpendicular to B0 and circularly polarized as in parallel whistlers. Helical antennas couple to these transverse fields but not to the spiral fields of helicons. Using a circular antenna array of phased m = 0 loops, right or left rotating or non-rotating multipole antenna fields are generated. They excite m < 0 and m > 0 modes, showing that the plasma supports both modes equally well. The poor excitation of m < 0 modes is a characteristic of loops with dipole moment across B0. The radiation efficiency of multipole antennas has been found to decrease with m.

  8. Helicon waves in uniform plasmas. II. High m numbers

    SciTech Connect

    Stenzel, R. L.; Urrutia, J. M.

    2015-09-15

    Helicons are whistler modes with azimuthal wave numbers. They have been studied in solids and plasmas where boundaries play a role. The present work shows that very similar modes exist in unbounded gaseous plasmas. Instead of boundaries, the antenna properties determine the topology of the wave packets. The simplest antenna is a magnetic loop which excites m = 0 or m = 1 helicons depending on whether the dipole moment is aligned parallel or perpendicular to the ambient background magnetic field B{sub 0}. While these low order helicons have been described by J. M. Urrutia and R. L. Stenzel [“Helicon modes in uniform plasmas. I. Low m modes,” Phys. Plasmas 22, 092111 (2015)], the present work focuses on high order modes up to m = 8. These are excited by antenna arrays forming magnetic multipoles. Their wave magnetic field has been measured in space and time in a large and uniform laboratory plasma free of boundary effects. The observed wave topology exhibits m pairs of unique field line spirals which may have inspired the name “helicon” to this mode. All field lines converge into these nested spirals which propagate like corkscrews along B{sub 0}. The field lines near the axis of helicons are perpendicular to B{sub 0} and circularly polarized as in parallel whistlers. Helical antennas couple to these transverse fields but not to the spiral fields of helicons. Using a circular antenna array of phased m = 0 loops, right or left rotating or non-rotating multipole antenna fields are generated. They excite m < 0 and m > 0 modes, showing that the plasma supports both modes equally well. The poor excitation of m < 0 modes is a characteristic of loops with dipole moment across B{sub 0}. The radiation efficiency of multipole antennas has been found to decrease with m.

  9. Accelerating piston action and plasma heating in high-energy density laser plasma interactions

    NASA Astrophysics Data System (ADS)

    Levy, M. C.; Wilks, S. C.; Baring, M. G.

    2013-03-01

    In the field of high-energy density physics (HEDP), lasers in both the nanosecond and picosecond regimes can drive conditions in the laboratory relevant to a broad range of astrophysical phenomena, including gamma-ray burst afterglows and supernova remnants. In the short-pulse regime, the strong light pressure (>Gbar) associated ultraintense lasers of intensity I > 1018 W/cm2 plays a central role in many HEDP applications. Yet, the behavior of this nonlinear pressure mechanism is not well-understood at late time in the laser-plasma interaction. In this paper, a more realistic treatment of the laser pressure 'hole boring' process is developed through analytical modeling and particle-in-cell simulations. A simple Liouville code capturing the phase space evolution of ponderomotively-driven ions is employed to distill effects related to plasma heating and ion bulk acceleration. Taking into account these effects, our results show that the evolution of the laser-target system encompasses ponderomotive expansion, equipartition, and quasi-isothermal expansion epochs. These results have implications for light piston-driven ion acceleration scenarios, and astrophysical applications where the efficiencies of converting incident Poynting flux into bulk plasma flow and plasma heat are key unknown parameters.

  10. Reduction of low- and high-grade cervical abnormalities associated with high uptake of the HPV bivalent vaccine in Scotland

    PubMed Central

    Pollock, K G J; Kavanagh, K; Potts, A; Love, J; Cuschieri, K; Cubie, H; Robertson, C; Cruickshank, M; Palmer, T J; Nicoll, S; Donaghy, M

    2014-01-01

    Background: In Scotland, a national HPV immunisation programme began in 2008 for 12- to 13-year olds, with a catch-up campaign from 2008 to 2011 for those under the age of 18. To monitor the impact of HPV immunisation on cervical disease at the population level, a programme of national surveillance was established. Methods: We analysed colposcopy data from a cohort of women born between 1988 and 1992 who entered the Scottish Cervical Screening Programme (SCSP) and were aged 20–21 in 2008–2012. Results: By linking datasets from the SCSP and colposcopy services, we observed a significant reduction in diagnoses of cervical intraepithelial neoplasia 1 (CIN 1; RR 0.71, 95% CI 0.58 to 0.87; P=0.0008), CIN 2 (RR 0.5, 95% CI 0.4 to 0.63; P<0.0001) and CIN 3 (RR 0.45, 95% CI 0.35 to 0.58; P<0.0001) for women who received three doses of vaccine compared with unvaccinated women. Conclusions: To our knowledge, this is one of the first studies to show a reduction of low- and high-grade CIN associated with high uptake of the HPV bivalent vaccine at the population level. These data are very encouraging for countries that have achieved high HPV vaccine uptake. PMID:25180766

  11. High-Pressure Unconditionally Stable Nonequilibrium Molecular Plasmas

    NASA Astrophysics Data System (ADS)

    Palm, Peter; Ploenjes, Elke; Adamovich, Igor; Rich, J. William

    2000-10-01

    A novel method of sustaining unconditionally stable, large-volume, high-pressure nonequilibrium plasmas is suggested. The plasma is initiated by resonance absorption of CO laser radiation by carbon monoxide gas mixed with nitrogen and oxygen or nitric oxide in an absorption cell followed by overpopulation of high vibrational levels of CO in vibration-vibration (V-V) energy exchange collisions, [ CO(v) + CO(w) leftharpoons CO(v-1) + CO(w+1) ] and subsequent ionization by an associative ionization mechanism, [ CO(v) + CO(w) arrow (CO)_2^+ + e^-, Ev + Ew >= E_ion. ] Free electrons produced by associative ionization are heated by a sub-breakdown RF field applied to the optically pumped plasma. The heated electrons lose their energy primarily in collisions with the molecules, thereby vibrationally exciting all molecules. This is followed by overpopulation of high vibrational levels of the molecules by the V-V exchange process and further associative ionization. Unconditional stability is enabled by a negative feedback between gas heating and ionization due to an increase of vibration-translation relaxation rates with temperature leading to rapid depopulation of high vibrational levels needed for associative ionization.

  12. Collisionless shock generation in high-speed counterstreaming plasma flows by a high-power laser

    SciTech Connect

    Morita, T.; Aoki, H.; Sakawa, Y.; Kuramitsu, Y.; Kato, T. N.; Dono, S.; Tanji, H.; Li, Y. T.; Zhang, Y.; Liu, X.; Zhong, J. Y.; Takabe, H.; Zhang, J.

    2010-12-15

    The experimental demonstration of the formation of a strong electrostatic (ES) collisionless shock has been carried out with high-speed counterstreaming plasmas, produced by a high-power laser irradiation, without external magnetic field. The nearly four times density jump observed in the experiment shows a high Mach-number shock. This large density jump is attributed to the compression of the downstream plasma by momentum transfer by ion reflection of the upstream plasma. Particle-in-cell (PIC) simulation shows the production of a collisionless high Mach-number ES shock with counterstreaming interaction of two plasma slabs with different temperatures and densities, as pointed out by Sorasio et al. [Phys. Rev. Lett. 96, 045005 (2006)]. It is speculated that the shock discontinuity is balanced with the momentum of incoming and reflected ions and the predominant pressure of the electrons in the downstream with PIC simulation.

  13. High-Density Plasma Reactors: Simulations for Design

    NASA Technical Reports Server (NTRS)

    Hash, David B.; Meyyappan, Meyya; Arnold, James O. (Technical Monitor)

    1998-01-01

    The development of improved and more efficient plasma reactors is a costly process for the semiconductor industry. Until five years ago, the Industry made most of its advancements through a trial and error approach. More recently, the role of computational modeling in the design process has increased. Both conventional computational fluid dynamics (CFD) techniques like Navier-Stokes solvers as well as particle simulation methods are used to model plasma reactor flowfields. However, since high-density plasma reactors generally operate at low gas pressures on the order of 1 to 10 mTorr, a particle simulation may be necessary because of the failure of CFD techniques to model rarefaction effects. The direct simulation Monte Carlo method is the most widely accepted and employed particle simulation tool and has previously been used to investigate plasma reactor flowfields. A plasma DSMC code is currently under development at NASA Ames Research Center with its foundation as the object-oriented parallel Cornell DSMC code, MONACO. The present investigation is a follow up of a neutral flow investigation of the effects of process parameters as well as reactor design on etch rate and etch rate uniformity. The previous work concentrated on silicon etch of a chlorine flow in a configuration typical of electron cyclotron resonance (ECR) or helical resonator type reactors. The effects of the plasma on the dissociation chemistry were modeled by making assumptions about the electron temperature and number density. The electrons or ions themselves were not simulated.The present work extends these results by simulating the charged species.The electromagnetic fields are calculated such that power deposition is modeled self-consistently. Electron impact reactions are modeled along with mechanisms for charge exchange. An bipolar diffusion assumption is made whereby electrons remain tied to the ions. However, the velocities of tile electrons are allowed to be modified during collisions

  14. Characterization of Inductively Coupled Plasmas in High Power, High Pressure Regime

    NASA Astrophysics Data System (ADS)

    Wang, Jun-Chieh; Kenney, Jason; Agarwal, Ankur; Nichols, Michael; Rogers, James; Rauf, Shahid

    2015-09-01

    Inductively coupled plasmas (ICP) are widely used in the microelectronic industry for thin film etching. ICPs have typically been operated at low gas pressures (<50 mTorr) and they have been well-characterized in this regime. Several applications requiring high etch rates (e.g., vertical NAND etch) have recently extended the use of ICPs to the high power (>4000 W) and high pressure (>100 mTorr) regime. ICP operation in this high-power, high-pressure regime imposes a tremendous challenge of achieving good plasma uniformity over large substrates. This necessitates a good theoretical understanding of the underlying physics, thorough experimental characterization, and more accurate numerical models for hardware design guidance. In this study, we will focus on the characterization of ICP in the high-power, high-pressure regime. Computational modeling is done using CRTRS, our in-house 2D/3D plasma model. The fluid plasma model is coupled to a circuit model to self-consistently account for the capacitive coupling from the coils that is expected to dominate in this operating regime. Properties of Ar plasma will be discussed and compared with experiments. The impact of critical operating parameters such as ICP power, pressure, flow rate, and current ratio (in multi-coil antenna structures) on plasma characteristics will be examined. Results in relevant processing gases will also be discussed.

  15. Long-lived Ar-Hg plasma in the afterglow of a high-current pulsed discharge

    SciTech Connect

    Sergeichev, K. F.; Lukina, N. A.; Fesenko, A. A.

    2013-02-15

    High-density (n > 10{sup 12} cm{sup -3}) argon-mercury plasma produced by a short (t {approx} 20 {mu}s) high-power pulsed discharge in argon with an admixture of mercury vapor at a discharge current of {approx}50 A, an argon pressure of {approx}4 mm Hg, and a mercury vapor pressure of {approx}10{sup -3} mm Hg was studied using optical spectroscopy and radio physics methods. It is found that the lifetime of this plasma after the end of the discharge pulse is up to 10{sup -2} s. It is shown that such an abnormally long lifetime of such an afterglow plasma, as compared to the plasma of an argon discharge without an admixture of mercury vapor, is related to the long residence time of atoms and ions of both argon and mercury in highly excited states due to chemi-ionization processes involving long-lived metastable argon ions. It is suggested that dissociative recombination of highly excited molecular ions of argon play an important role in the transfer of excitation to argon atoms and ions that are close to autoionization states.

  16. High-contrast plasma-electrode Pockels cell

    SciTech Connect

    Kruschwitz, B. E.; Kelly, J. H.; Shoup, M. J. III; Waxer, L. J.; Cost, E. C.; Green, E. T.; Hoyt, Z. M.; Taniguchi, J.; Walker, T. W

    2007-03-10

    A plasma-electrode Pockels cell (PEPC) has been developed for use on the OMEGA extended performance (EP)laser system that can be used in a high-contrast optical switch, as required for isolation of the system from retroreflected pulses. Contrast ratios reliably exceeded 500:1 locally everywhere in the clear aperture. The key to achieving this improvement was the use of circular windows simply supported on compliant O rings, which is shown to produce very low stress-induced birefringence despite vacuum loading. Reliable operation was achieved operating at a relatively high operating pressure, low operating pressures being found to be strongly correlated to occurrences of local loss of plasma density.

  17. High Dynamic Range Characterization of the Trauma Patient Plasma Proteome

    SciTech Connect

    Liu, Tao; Qian, Weijun; Gritsenko, Marina A.; Xiao, Wenzhong; Moldawer, Lyle L.; Kaushal, Amit; Monroe, Matthew E.; Varnum, Susan M.; Moore, Ronald J.; Purvine, Samuel O.; Maier, Ronald V.; Davis, Ronald W.; Tompkins, Ronald G.; Camp, David G.; Smith, Richard D.

    2006-06-08

    While human plasma represents an attractive sample for disease biomarker discovery, the extreme complexity and large dynamic range in protein concentrations present significant challenges for characterization, candidate biomarker discovery, and validation. Herein, we describe a strategy that combines immunoaffinity subtraction and chemical fractionation based on cysteinyl peptide and N-glycopeptide captures with 2D-LC-MS/MS to increase the dynamic range of analysis for plasma. Application of this ''divide-and-conquer'' strategy to trauma patient plasma significantly improved the overall dynamic range of detection and resulted in confident identification of 22,267 unique peptides from four different peptide populations (cysteinyl peptides, non-cysteinyl peptides, N-glycopeptides, and non-glycopeptides) that covered 3654 nonredundant proteins. Numerous low-abundance proteins were identified, exemplified by 78 ''classic'' cytokines and cytokine receptors and by 136 human cell differentiation molecules. Additionally, a total of 2910 different N-glycopeptides that correspond to 662 N-glycoproteins and 1553 N-glycosylation sites were identified. A panel of the proteins identified in this study is known to be involved in inflammation and immune responses. This study established an extensive reference protein database for trauma patients, which provides a foundation for future high-throughput quantitative plasma proteomic studies designed to elucidate the mechanisms that underlie systemic inflammatory responses.

  18. Assessment of plasma gasification of high caloric waste streams.

    PubMed

    Lemmens, Bert; Elslander, Helmut; Vanderreydt, Ive; Peys, Kurt; Diels, Ludo; Oosterlinck, Michel; Joos, Marc

    2007-01-01

    Plasma gasification is an innovative technology for transforming high calorific waste streams into a valuable synthesis gas and a vitrified slag by means of a thermal plasma. A test program has been set up to evaluate the feasibility of plasma gasification and the impact of this process on the environment. RDF (refuse derived fuel) from carpet and textile waste was selected as feed material for semi-pilot gasification tests. The aim of the tests was: (1) to evaluate the technical feasibility of making a stable synthesis gas; (2) to characterize the composition of this synthesis gas; (3) to define a suitable after-treatment configuration for purification of the syngas and (4) to characterize the stability of the slag, i.e., its resistance to leaching for use as a secondary building material. The tests illustrate that plasma gasification can result in a suitable syngas quality and a slag, characterized by an acceptable leachability. Based on the test results, a further scale-up of this technology will be prepared and validation tests run. PMID:17134888

  19. X-ray emission from high temperature plasmas

    NASA Technical Reports Server (NTRS)

    Harries, W. L.

    1975-01-01

    The bremsstrahlung X-rays from a plasma focus device were investigated with emphasis on the emission versus position, time, energy, and angle of emission. It is shown that low energy X-rays come from the plasma focus region, but that the higher energy components come from the anode. The emission is anisotropic, the low energy polar diagram resembling a cardioid, while the high energy emission is a lobe into the anode. The plasma parameters were considered indicating that even in the dense focus, the plasma is collisionless near the axis. By considering the radiation patterns of relativistic electrons a qualitative picture is obtained, which explains the measured polar diagrams, assuming the electrons that produce the X-rays have velocity vectors lying roughly in a cone between the point of focus and the anode. The average electron energy is about 3keV at the focus and about 10 keV on the anode surface. Results are consistent with the converging beam model of neutron production.

  20. Fluid hydrogen at high density - The plasma phase transition

    NASA Technical Reports Server (NTRS)

    Saumon, D.; Chabrier, G.

    1989-01-01

    A new model equation of state is applied, based on realistic interparticle potentials and a self-consistent treatment of the internal levels, to fluid hydrogen at high density. This model shows a strong connection between molecular dissociation and pressure ionization. The possibility of a first-order plasma phase transition is considered, and for which both the evolution in temperature and the critical point is given.

  1. Analysis of Electron Trajectories in Magnetized High Power Plasmas

    NASA Astrophysics Data System (ADS)

    Krueger, Dennis; Gallian, Sara; Trieschmann, Jan; Brinkmann, Ralf Peter

    2015-09-01

    High Power Impulse Magnetron Sputtering (HiPIMS) is an important example of magnetized technological plasmas. With HiPIMS the focus lies on the generation of a high density plasma with a remarkably high degree of ionization. It can be used for the deposition of thin films with superior density and quality. Theoretical approaches to the regime of magnetized low temperature plasmas encounter some fundamental difficulties, for example concerning the details of the magnetic field configuration, the strongly varying degree of magnetization, and the frequent wall interactions. A kinetic single particle model is used for the investigations. Single electron trajectories are analyzed with the widely used Boris algorithm within the magnetized zone above the target (racetrack). We further examine a configuration where symmetry breaking occurs due to a potential bump, which is rotating azimuthally around the racetrack (spoke). Observing the effects of this structure on the single electron motion may allow us to obtain further insight into this phenomenon. This work is supported by the German Research Foundation in the frame of the Collaborative Research Centre TRR 87.

  2. Plasma polymerized high energy density dielectric films for capacitors

    NASA Technical Reports Server (NTRS)

    Yamagishi, F. G.

    1983-01-01

    High energy density polymeric dielectric films were prepared by plasma polymerization of a variety of gaseous monomers. This technique gives thin, reproducible, pinhole free, conformable, adherent, and insoluble coatings and overcomes the processing problems found in the preparation of thin films with bulk polymers. Thus, devices are prepared completely in a vacuum environment. The plasma polymerized films prepared all showed dielectric strengths of greater than 1000 kV/cm and in some cases values of greater than 4000 kV/cm were observed. The dielectric loss of all films was generally less than 1% at frequencies below 10 kHz, but this value increased at higher frequencies. All films were self healing. The dielectric strength was a function of the polymerization technique, whereas the dielectric constant varied with the structure of the starting material. Because of the thin films used (thickness in the submicron range) surface smoothness of the metal electrodes was found to be critical in obtaining high dielectric strengths. High dielectric strength graft copolymers were also prepared. Plasma polymerized ethane was found to be thermally stable up to 150 C in the presence of air and 250 C in the absence of air. No glass transitions were observed for this material.

  3. Mechanisms for plasma formation during high power pumping of XPAL

    NASA Astrophysics Data System (ADS)

    Babaeva, Natalia Yu.; Zatsarinny, Oleg; Bartschat, Klaus; Kushner, Mark J.

    2014-02-01

    During operation of the excimer pumped alkali laser, XPAL, large densities of alkali excited states are produced. Through superelastic electron collisional relaxation of these states, any pre-existing electrons will be heated, leading to additional ionization. The end result is plasma formation. A first principles global model has been developed for the Ar/Cs XPAL system to investigate the possible formation of plasma during high repetition rate, high power pumping; and the consequences on laser performance. Four- and five-level pumping schemes were used to enable assessment of XPAL operating on the Cs(62P3/2) → Cs(62S1/2) (852 nm) and Cs(62P1/2) → Cs(62S1/2) (894 nm) transitions. The model was parameterized as a function of pump power, excitation frequency, cell temperature (Cs vapor pressure) and collision mixing agent (N2) mole fraction. We found that at sufficiently high operating temperature, pump power and repetition rate, plasma formation in excess of 1014-1016 cm-3 occurs, which potentially reduces laser output power by electron collisional mixing of the upper and lower laser levels.

  4. Plasma Tunable LC Resonator for High-Power Electromagnetic Applications

    NASA Astrophysics Data System (ADS)

    Semnani, Abbas; Macheret, Sergey; Peroulis, Dimitrios

    2015-09-01

    High-power tunable filters are in high demand in transmitters found in radars and many communication systems such as satellite and broadcasting stations. Limited power handling renders most semiconductor technologies inherently suboptimal options for these systems. Therefore, mechanically-tunable cavity-based filters are often employed in such cases, resulting in bulky, slow, and heavy systems. In this work, we study the application of plasma as an alternative frequency tuning mechanism for high-power applications even in environmentally and/or mechanically harsh conditions. For a given gas type and pressure, the real and imaginary parts of the dielectric permittivity of a plasma can be varied by changing the electron density, which, depending on the discharge regime, can be implemented by changing the discharge current, voltage, or the magnitude of an auxiliary electric field. In this work, a simple LC resonator tuned to several hundred MHz was fabricated and tested. The tunable capacitor of the resonator was implemented by a commercially available gas discharge tube (GDT), a mm-scale plasma device with gas pressure of 100s of mTorr. Measurement results reveal a continuous tuning range of more than 50% when the applied discharge current is increased from zero to 90 mA.

  5. Development of compact high voltage switched mode power supply for microwave plasma sources supply for low pressure plasma

    NASA Astrophysics Data System (ADS)

    Kerdtongmee, P.; Srinoum, D.; Nisoa, M.

    2011-08-01

    Although microwave induced plasmas are well known as high efficiency plasma sources, their uses in laboratories are limited since the microwave power systems are complicated and expensive. The output power of commercially available low-cost microwave ovens is fixed and discontinuous resulting from the high voltage doubler topology of the magnetron tube power supply. In this paper, a high voltage switched mode power supply of forward topology has been developed for continuous microwave power radiation. The forward converter can generate a no-load high voltage output maximum of 7 kV. When driving the magnetron tube, the microwave output power could be varied from 0 to 35 W while the high voltage output level was constantly regulated at -3.4 kV. A microwave induced plasma system was setup to investigate the plasma produced. A low pressure argon plasma was produced with only 2 W over a wide range of pressures.

  6. Three plasma metabolite signatures for diagnosing high altitude pulmonary edema

    PubMed Central

    Guo, Li; Tan, Guangguo; Liu, Ping; Li, Huijie; Tang, Lulu; Huang, Lan; Ren, Qian

    2015-01-01

    High-altitude pulmonary edema (HAPE) is a potentially fatal condition, occurring at altitudes greater than 3,000 m and affecting rapidly ascending, non-acclimatized healthy individuals. However, the lack of biomarkers for this disease still constitutes a bottleneck in the clinical diagnosis. Here, ultra-high performance liquid chromatography coupled with Q-TOF mass spectrometry was applied to study plasma metabolite profiling from 57 HAPE and 57 control subjects. 14 differential plasma metabolites responsible for the discrimination between the two groups from discovery set (35 HAPE subjects and 35 healthy controls) were identified. Furthermore, 3 of the 14 metabolites (C8-ceramide, sphingosine and glutamine) were selected as candidate diagnostic biomarkers for HAPE using metabolic pathway impact analysis. The feasibility of using the combination of these three biomarkers for HAPE was evaluated, where the area under the receiver operating characteristic curve (AUC) was 0.981 and 0.942 in the discovery set and the validation set (22 HAPE subjects and 22 healthy controls), respectively. Taken together, these results suggested that this composite plasma metabolite signature may be used in HAPE diagnosis, especially after further investigation and verification with larger samples. PMID:26459926

  7. Three plasma metabolite signatures for diagnosing high altitude pulmonary edema

    NASA Astrophysics Data System (ADS)

    Guo, Li; Tan, Guangguo; Liu, Ping; Li, Huijie; Tang, Lulu; Huang, Lan; Ren, Qian

    2015-10-01

    High-altitude pulmonary edema (HAPE) is a potentially fatal condition, occurring at altitudes greater than 3,000 m and affecting rapidly ascending, non-acclimatized healthy individuals. However, the lack of biomarkers for this disease still constitutes a bottleneck in the clinical diagnosis. Here, ultra-high performance liquid chromatography coupled with Q-TOF mass spectrometry was applied to study plasma metabolite profiling from 57 HAPE and 57 control subjects. 14 differential plasma metabolites responsible for the discrimination between the two groups from discovery set (35 HAPE subjects and 35 healthy controls) were identified. Furthermore, 3 of the 14 metabolites (C8-ceramide, sphingosine and glutamine) were selected as candidate diagnostic biomarkers for HAPE using metabolic pathway impact analysis. The feasibility of using the combination of these three biomarkers for HAPE was evaluated, where the area under the receiver operating characteristic curve (AUC) was 0.981 and 0.942 in the discovery set and the validation set (22 HAPE subjects and 22 healthy controls), respectively. Taken together, these results suggested that this composite plasma metabolite signature may be used in HAPE diagnosis, especially after further investigation and verification with larger samples.

  8. Simulation of transition dynamics to high confinement in fusion plasmas

    NASA Astrophysics Data System (ADS)

    Nielsen, A. H.; Xu, G. S.; Madsen, J.; Naulin, V.; Juul Rasmussen, J.; Wan, B. N.

    2015-12-01

    The transition dynamics from the low (L) to the high (H) confinement mode in magnetically confined plasmas is investigated using a first-principles four-field fluid model. Numerical results are in agreement with measurements from the Experimental Advanced Superconducting Tokamak - EAST. Particularly, the slow transition with an intermediate dithering phase is well reproduced at proper parameters. The model recovers the power threshold for the L-H transition as well as the decrease in power threshold switching from single to double null configuration observed experimentally. The results are highly relevant for developing predictive models of the transition, essential for understanding and optimizing future fusion power reactors.

  9. Plasma Switch for High-Power Active Pulse Compressor

    SciTech Connect

    Hirshfield, Jay L.

    2013-11-04

    Results are presented from experiments carried out at the Naval Research Laboratory X-band magnicon facility on a two-channel X-band active RF pulse compressor that employed plasma switches. Experimental evidence is shown to validate the basic goals of the project, which include: simultaneous firing of plasma switches in both channels of the RF circuit, operation of quasi-optical 3-dB hybrid directional coupler coherent superposition of RF compressed pulses from both channels, and operation of the X-band magnicon directly in the RF pulse compressor. For incident 1.2 ?s pulses in the range 0.63 ? 1.35 MW, compressed pulses of peak powers 5.7 ? 11.3 MW were obtained, corresponding to peak power gain ratios of 8.3 ? 9.3. Insufficient bakeout and conditioning of the high-power RF circuit prevented experiments from being conducted at higher RF input power levels.

  10. Measurements of uranium mass confined in high density plasmas

    NASA Technical Reports Server (NTRS)

    Stoeffler, R. C.

    1976-01-01

    An X-ray absorption method for measuring the amount of uranium confined in high density, rf-heated uranium plasmas is described. A comparison of measured absorption of 8 keV X-rays with absorption calculated using Beer Law indicated that the method could be used to measure uranium densities from 3 times 10 to the 16th power atoms/cu cm to 5 times 10 to the 18th power atoms/cu cm. Tests were conducted to measure the density of uranium in an rf-heated argon plasma with UF6 infection and with the power to maintain the discharge supplied by a 1.2 MW rf induction heater facility. The uranium density was measured as the flow rate through the test chamber was varied. A maximum uranium density of 3.85 times 10 to the 17th power atoms/cu cm was measured.

  11. EUV spectroscopy of highly charged high Z ions in the Large Helical Device plasmas

    NASA Astrophysics Data System (ADS)

    Suzuki, C.; Koike, F.; Murakami, I.; Tamura, N.; Sudo, S.; Sakaue, H. A.; Nakamura, N.; Morita, S.; Goto, M.; Kato, D.; Nakano, T.; Higashiguchi, T.; Harte, C. S.; OʼSullivan, G.

    2014-11-01

    We present recent results on the extreme ultraviolet (EUV) spectroscopy of highly charged high Z ions in plasmas produced in the Large Helical Device (LHD) at the National Institute for Fusion Science. Tungsten, bismuth and lanthanide elements have recently been studied in the LHD in terms of their importance in fusion research and EUV light source development. In relatively low temperature plasmas, quasicontinuum emissions from open 4d or 4f subshell ions are predominant in the EUV region, while the spectra tend to be dominated by discrete lines from open 4s or 4p subshell ions in higher temperature plasmas. Comparative analyses using theoretical calculations and charge-separated spectra observed in an electron beam ion trap have been performed to achieve better agreement with the spectra measured in the LHD. As a result, databases on Z dependence of EUV spectra in plasmas have been widely extended.

  12. Ion drag force on an absorbing grain in highly collisional plasma in the presence of plasma production and loss processes

    SciTech Connect

    Chaudhuri, Manis; Khrapak, Sergei A.; Morfill, Gregor E.

    2008-09-07

    The ion drag force acting on a small absorbing spherical grain has been calculated analytically in highly collisional plasma with slowly drifting ions taking into account plasma production and loss mechanisms in the vicinity of the grain. It is shown that both the magnitude and direction of the ion drag force are strongly influenced by the plasma production and loss mechanisms. The parameter regimes for the 'positive' and 'negative' ion drag forces acting on an absorbing grain have been identified.

  13. Associations between sexually transmitted infections, high-risk human papillomavirus infection, and abnormal cervical Pap smear results in OB/GYN outpatients

    PubMed Central

    Kim, Tae Jin

    2016-01-01

    Objective This study aimed to examine the meaning and usefulness of sexually transmitted infection (STI) test when caring for patients who have abnormal cervical cytology and/or positive high-risk human papillomavirus (HPV) DNA test results. Methods Among patients who underwent liquid-based cervical cytology and HPV DNA tests at the Obstetrics and Gynecology outpatient clinic, 800 patients who showed abnormal cervical cytology were compared with 200 patients in the control group. Both groups were simultaneously tested via multiplex real-time polymerase chain reaction for seven types of STI-causative microorganisms. Results The positive rate of high-risk HPV infection in total STIs positive group was 1.47 times higher than that of total STIs negative group. The probability of a cytological diagnosis of a grade equal to or higher than atypical squamous cells-cannot exclude high grade squamous intraepithelial lesion (ASC-H) was significantly higher in patients testing positive for total STIs (1.46 times), Chlamydia trachomatis (3.21 times), or Mycoplasma genitalicum (3.58 times) than in those testing negative. The total STIs positive rate was significantly higher for those having a cytological diagnosis of a grade equal to or higher than atypical squamous cells of undetermined significance (ASC-US) when high-risk HPV test result was negative. Conclusion Correlations were present not only between STIs and high-risk HPV infection but also between abnormal cervical cytology and STIs. Therefore, additional evaluation of STIs will be helpful to appropriately diagnose and treat patients with abnormal cervical cytology, positive results on high-risk HPV DNA test, or a cytological diagnosis of ASC-US despite negative high-risk HPV DNA test result. PMID:27329197

  14. Exploration of Plasma Jets Approach to High Energy Density Physics. Final report

    SciTech Connect

    Chen, Chiping

    2013-08-26

    High-energy-density laboratory plasma (HEDLP) physics is an emerging, important area of research in plasma physics, nuclear physics, astrophysics, and particle acceleration. While the HEDLP regime occurs at extreme conditions which are often found naturally in space but not on the earth, it may be accessible by colliding high intensity plasmas such as high-energy-density plasma jets, plasmoids or compact toroids from plasma guns. The physics of plasma jets is investigated in the context of high energy density laboratory plasma research. This report summarizes results of theoretical and computational investigation of a plasma jet undergoing adiabatic compression and adiabatic expansion. A root-mean-squared (rms) envelope theory of plasma jets is developed. Comparison between theory and experiment is made. Good agreement between theory and experiment is found.

  15. High order methods for elliptic problems in plasma physics

    NASA Astrophysics Data System (ADS)

    Pataki, Andras

    In this dissertation, we develop fast high order solvers for two elliptic problems in plasma physics. The first is the Grad-Shafranov equation, a nonlinear elliptic PDE that describes the magnetohydrodynamic equilibrium of three dimensional, axisymmetric plasmas. A high order solver is desirable to ensure the accurate evaluation of derivatives, required both for the computation of physical quantities and for studying perturbations near equilibrium. Using suitable scaling, we transform the problem from cylindrical coordinates to a nonlinear Poisson problem in Cartesian coordinates. We compute the conformal map from the original domain to the unit circle where we build a separation of variables based solver to obtain a high order, accurate solution. A fixed point or eigenvalue outer iteration is used to solve the nonlinear equation. Our second problem is the computation of the Coulomb collision operator that arises in kinetic models of plasmas. The collision operator can be written in terms of two Rosenbluth potentials obtained by solving a Poisson and a biharmonic problem in the velocity variables. For these PDEs we describe a new class of fast solvers in cylindrical coordinates with free-space radiation conditions. By combining integral equation methods in the radial variable with Fourier methods in the angular and z directions, we show that high-order accuracy can be achieved in both the solution and its derivatives. A weak singularity arises in the Fourier transform with respect to z that is handled with special purpose quadratures. Such solvers are ideally suited to the Rosenbluth potentials, since the collision operator is expressed in terms of up to fourth derivatives of the potentials, placing stringent demands on the computational order. Also, since axisymmetry is generally assumed in the velocity variables, the use of cylindrical coordinates reduces the three dimensional problem to a two dimensional computation.

  16. Computerized rapid high resolution quantitative analysis of plasma lipoproteins based upon single vertical spin centrifugation.

    PubMed

    Cone, J T; Segrest, J P; Chung, B H; Ragland, J B; Sabesin, S M; Glasscock, A

    1982-08-01

    A method has been developed for rapidly quantitating the cholesterol concentration of normal and certain variant lipoproteins in a large number of patients (over 240 in one week). The method employs a microcomputer interfaced to the vertical autoprofiler (VAP) described earlier (Chung et al. 1981. J. Lipid Res. 22: 1003-1014). Software developed to accomplish rapid on-line analysis of the VAP signal uses peak shapes and positions derived from prior VAP analysis of isolated authentic lipoproteins HDL, LDL, and VLDL to quantitate these species in a VAP profile. Variant lipoproteins VHDL (a species with density greater than that of HDL(3)), MDL (a species, most likely Lp(a), with density intermediate between that of HDL and LDL), and IDL are subsequently quantitated by a method combining difference calculations with curve shapes. The procedure has been validated qualitatively by negative stain electron microscopy, gradient gel electrophoresis, strip electrophoresis, chemical analysis of the lipids, radioimmunoassay of the apolipoproteins, and measurement of the density of the peak centers. It has been validated quantitatively by comparison with Lipid Research Clinic methodology for HDL-, LDL-, and VLDL-cholesterol, and for MDL- and IDL-cholesterol by comparison of the amounts of MDL or IDL predicted to be present by the method with that known to be present following standard addition to whole plasma. These validations show that the method is a rapid and accurate technique of lipoprotein analysis suitable for the routine screening of patients for abnormal amounts of normal or variant lipoproteins, as well as for use as a research tool for quantitation of changes in cholesterol content of six or seven different plasma lipoprotein fractions.-Cone, J. T., J. P. Segrest, B. H. Chung, J. B. Ragland, S. M. Sabesin, and A. Glasscock. Computerized rapid high resolution quantitative analysis of plasma lipoproteins based upon single vertical spin centrifugation. PMID:7130860

  17. Plasma potential mapping of high power impulse magnetron sputtering discharges

    SciTech Connect

    Rauch, Albert; Mendelsberg, Rueben J.; Sanders, Jason M.; Anders, Andre

    2012-04-15

    Pulsed emissive probe techniques have been used to determine the plasma potential distribution of high power impulse magnetron sputtering (HiPIMS) discharges. An unbalanced magnetron with a niobium target in argon was investigated for a pulse length of 100 {mu}s at a pulse repetition rate of 100 Hz, giving a peak current of 170 A. The probe data were recorded with a time resolution of 20 ns and a spatial resolution of 1 mm. It is shown that the local plasma potential varies greatly in space and time. The lowest potential was found over the target's racetrack, gradually reaching anode potential (ground) several centimeters away from the target. The magnetic presheath exhibits a funnel-shaped plasma potential resulting in an electric field which accelerates ions toward the racetrack. In certain regions and times, the potential exhibits weak local maxima which allow for ion acceleration to the substrate. Knowledge of the local E and static B fields lets us derive the electrons'ExB drift velocity, which is about 10{sup 5} m/s and shows structures in space and time.

  18. Plasma potential mapping of high power impulse magnetron sputtering discharges

    SciTech Connect

    Rauch, Albert; Mendelsberg, Rueben J.; Sanders, Jason M.; Anders, Andre

    2011-12-20

    Pulsed emissive probe techniques have been used to determine the plasma potential distribution of high power impulse magnetron sputtering (HiPIMS) discharges. An unbalanced magnetron with a niobium target in argon was investigated for pulse length of 100 μs at a pulse repetition rate of 100 Hz, giving a peak current of 170 A. The probe data were taken with a time resolution of 20 ns and a spatial resolution of 1 mm. It is shown that the local plasma potential varies greatly in space and time. The lowest potential was found over the target’s racetrack, gradually reaching anode potential (ground) several centimeters away from the target. The magnetic pre-sheath exhibits a funnel-shaped plasma potential resulting in an electric field which accelerates ions toward the racetrack. In certain regions and times, the potential exhibits weak local maxima which allow for ion acceleration to the substrate. Knowledge of the local E and static B fields lets us derive the electrons’ E×B drift velocity, which is about 105 m/s and shows structures in space and time.

  19. Development of High-Density Plasma Photonic Crystals Using High-Power Lasers

    NASA Astrophysics Data System (ADS)

    Colon Quinones, Roberto; Wang, Benjamin; Lucca Fabris, Andrea; Cappelli, Mark

    2015-09-01

    A plasma photonic crystal (PPC) is an array of plasma structures that interacts with electromagnetic (EM) waves in ways not possible with natural materials. 2D PPCs can be used for generating a band gap, which is a range of wave frequencies in which no waves are transmitted through the structure. Such gap forms when an EM wave travels through a 2D PPC with spacing equal to half the wavelength of the wave and plasma frequency (ωp) on the order of the frequency of the wave. Until recently, research on PPCs has been limited to ωp < 30 GHz, which is equivalent to a plasma density of ne <1013 cm-3 . Over the last year, PPCs of ne >1015 cm-3 have been generated at Stanford through the use of high-power lasers. The PPCs are generated by expanding the laser beam from a Q-switched Nd:YAG laser through a Galilean beam expander and subsequently focusing the beam through an optical micro-lens array. The intense photoionization of air that occurs at the focus of the individual lenses leads to the formation of a 2D array of very dense plasma spots. Photomultiplier measurements show a plasma lifetime of ~150 ns during which the plasma array functions as a PPC, representing a first step towards advancing the field forward into the low THz regime. Sponsored by the AFOSR MURI and DoD NDSEG.

  20. Observations of shear flows in high-energy-density plasmas

    NASA Astrophysics Data System (ADS)

    Harding, Eric C.

    The research discussed in this thesis represents work toward the demonstration of experimental designs for creating a Kelvin-Helmholtz (KH) unstable shear layer in a high-energy-density (HED) plasma. Such plasmas are formed by irradiating materials with several kilo-Joules of laser light over a few nanoseconds, and are defined as having an internal pressure greater than one-million atmospheres. Similar plasmas exist in laboratory fusion experiments and in the astrophysical environment. The KH instability is a fundamental fluid instability that arises when strong velocity gradients exist at the interface between two fluids. The KH instability is important because it drives the mixing of fluids and initiates the transition to turbulence in the flow. Until now, the evolution of the KH instability has remained relatively unexplored in the HED regime This thesis presents the observations and analysis of two novel experiments carried out using two separate laser facilities. The first experiment used 1.4 kJ from the Nike laser to generate a supersonic flow of Al plasma over a low-density, rippled foam surface. The Al flow interacted with the foam and created distinct features that resulted from compressible effects. In this experiment there is little evidence of the KH instability. Nevertheless, this experimental design has perhaps pioneered a new method for generating a supersonic shear flow that has the potential to produce the KH instability if more laser energy is applied. The second experiment was performed on the Omega laser. In this case 4.3 kJ of laser energy drove a blast wave along a rippled foam/plastic interface. In response to the vorticity deposited and the shear flow established by the blast wave, the interface rolls up into large vorticies characteristic of the KH instability. The Omega experiment was the first HED experiment to capture the evolution of the KH instability.

  1. High and abnormal forms of aggression in rats with extremes in trait anxiety--involvement of the dopamine system in the nucleus accumbens.

    PubMed

    Beiderbeck, Daniela I; Reber, Stefan O; Havasi, Andrea; Bredewold, Remco; Veenema, Alexa H; Neumann, Inga D

    2012-12-01

    A better neurobiological understanding of high and abnormal aggression based on adequate animal models is essential for novel therapy and prevention. Selective breeding of rats for extremes in anxiety-related behavior resulted in two behavioral phenotypes with high and abnormal forms of aggression. Rats bred for low anxiety-related behavior (LAB) consistently show highest levels of aggression and little social investigation in the resident-intruder (RI) test, compared with non-selected low-aggressive (NAB) rats. High anxiety-related (HAB) rats also show higher levels of aggression than NAB rats, but to a lesser extent than LAB rats. Accordingly, extremes in inborn anxiety in both directions are linked to an increased aggression level. Further, both LAB and HAB, but not NAB males, display abnormal aggression (attacks towards vulnerable body parts, females or narcotized males), which is particularly prominent in LABs. Also, only in LAB rats, the nucleus accumbens (NAc) was found to be strongly activated in response to the RI test as reflected by increased c-fos and zif268 mRNA expression, and higher local dopamine release compared with NAB males, without differences in local dopamine receptor binding. Consequently, local pharmacological manipulation by infusion of an anesthetic (lidocaine, 20 μg/μl) or a dopamine D2 (haloperidol, 10 ng/μl), but not D1 (SCH-23390 10 ng/μl), receptor antagonist significantly reduced high aggression in LAB rats. Thus, LAB rats are an adequate model to study high and abnormal aggression. In LAB males, this is likely to be linked to hyper-activation of the reward system, as found in psychopathic patients. Specifically, activation of the accumbal dopamine system is likely to underlie the high aggression observed in LAB rats. PMID:22608548

  2. Age and sensory processing abnormalities predict declines in encoding and recall of temporally manipulated speech in high-functioning adults with ASD.

    PubMed

    Mayer, Jennifer L; Heaton, Pamela F

    2014-02-01

    While temporal and perceptual processing abnormalities, identified in a number of electrophysiological and brain imaging studies of individuals with (ASD), are likely to impact on speech perception, surprisingly little is known about the behavioral outcomes of such abnormalities. It has been hypothesized that rapid temporal processing deficits may be linked to impaired language development through interference with acoustic information during speech perception. The present study aimed to investigate the impact of temporal changes on encoding and recall of speech, and the associated cognitive, clinical, and behavioral correlates in adults with ASD. Research carried out with typically developing (TD) adults has shown that word recall diminishes as the speed of speech increases, and it was predicted that the magnitude of this effect would be far greater in those with ASD because of a preexisting rapid temporal processing deficit. Nineteen high-functioning adults with ASD, and age- and intelligence-matched TD controls performed verbatim recall of temporally manipulated sentences. Reduced levels of word recall in response to increases in presentation speed were observed, and this effect was greater in the older participants in the ASD group than in the control group. This is the first study to show that both sensory abnormalities and aging impact on speech encoding in ASD. Auditory processing deficits in ASD may be indicative of an association with the sensory abnormalities and social and communication impairments characterizing the disorder. PMID:24106132

  3. Is abnormal non-high-density lipoprotein cholesterol a gender-specific predictor for metabolic syndrome in patients with schizophrenia taking second-generation antipsychotics?

    PubMed

    Lin, Esther Ching-Lan; Shao, Wen-Chuan; Yang, Hsin-Ju; Yen, Miaofen; Lee, Sheng-Yu; Wu, Pei-Chun; Lu, Ru-Band

    2015-02-01

    Evidence supports an association between metabolic syndrome (MetS) and schizophrenia. However, specific risk factors for MetS and gender differences in patients with schizophrenia taking second-generation antipsychotics (SGAs) have not been well explored. A cross-sectional cohort of 329 Han Chinese patients was recruited in a psychiatric hospital in central Taiwan. Using the definitions of the International Diabetes Federation for Chinese, the prevalence of MetS was 23.7% (men: 25.7%; women: 21.2%). Logistic regression analyses showed that patients with a BMI ≥ 24 and an abnormal non-high-density lipoprotein cholesterol (non-HDL-C) were significantly (p < 0.001) more likely to develop MetS. A BMI ≥ 24 was a significant risk factor in men (OR: 6.092, p < 0.001) and women (OR: 5.886, p < 0.001). An abnormal non-HDL-C was a significant specific risk factor for men with MetS (OR: 4.127, p < 0.001), but not for women. This study supports a greater prevalence of MetS in patients with schizophrenia taking SGAs than in the general population. Abnormal BMI and non-HDL-C were significantly associated with developing MetS, and an abnormal non-HDL-C was a specific risk factor for men. Future development of specific interventions and regular monitoring for MetS is imperative for early identification and prevention. PMID:25034455

  4. High-Intensity Plasma Glass Melter Final Technical Report

    SciTech Connect

    Gonterman, J. Ronald; Weinstein, Michael A.

    2006-10-27

    frits. Exploratory melts of non-glassy materials, such as wollastonite, zirconium silicate, and alumino-silicate melts were successfully done indicating that plasma melting has potential application beyond glass. Experimental results were generated that show the high quality of plasma-melted fiberglass compositions, such as E-glass, can result in good fiberizing performance. Fiberizing performance and tensile strength data were achieved during the project to support this conclusion. High seed counts are a feature of the current lab scale melter and must be dealt with via other means, since fining work was outside the scope of this project.

  5. High-Q plasmas in the TFTR tokamak

    NASA Astrophysics Data System (ADS)

    Jassby, D. L.; Barnes, C. W.; Bell, M. G.; Bitter, M.; Boivin, R.; Bretz, N. L.; Budny, R. V.; Bush, C. E.; Dylla, H. F.; Efthimion, P. C.; Fredrickson, E. D.; Hawryluk, R. J.; Hill, K. W.; Hosea, J.; Hsuan, H.; Janos, A. C.; Jobes, F. C.; Johnson, D. W.; Johnson, L. C.; Kamperschroer, J.; Kieras-Phillips, C.; Kilpatrick, S. J.; LaMarche, P. H.; LeBlanc, B.; Mansfield, D. K.; Marmar, E. S.; McCune, D. C.; McGuire, K. M.; Meade, D. M.; Medley, S. S.; Mikkelsen, D. R.; Mueller, D.; Owens, D. K.; Park, H. K.; Paul, S. F.; Pitcher, S.; Ramsey, A. T.; Redi, M. H.; Sabbagh, S. A.; Scott, S. D.; Snipes, J.; Stevens, J.; Strachan, J. D.; Stratton, B. C.; Synakowski, E. J.; Taylor, G.; Terry, J. L.; Timberlake, J. R.; Towner, H. H.; Ulrickson, M.; von Goeler, S.; Wieland, R. M.; Williams, M.; Wilson, J. R.; Wong, K.-L.; Young, K. M.; Zarnstorff, M. C.; Zweben, S. J.

    1991-08-01

    In the Tokamak Fusion Test Reactor (TFTR) [Plasma Phys. Controlled Fusion 26, 11 (1984)], the highest neutron source strength Sn and D-D fusion power gain QDD are realized in the neutral-beam-fueled and heated ``supershot'' regime that occurs after extensive wall conditioning to minimize recycling. For the best supershots, Sn increases approximately as P1.8b. The highest-Q shots are characterized by high Te (up to 12 keV), Ti (up to 34 keV), and stored energy (up to 4.7 MJ), highly peaked density profiles, broad Te profiles, and lower Zeff. Replacement of critical areas of the graphite limiter tiles with carbon-fiber composite tiles and improved alignment with the plasma have mitigated the ``carbon bloom.'' Wall conditioning by lithium pellet injection prior to the beam pulse reduces carbon influx and particle recycling. Empirically, QDD increases with decreasing pre-injection carbon radiation, and increases strongly with density peakedness [ne(0)/] during the beam pulse. To date, the best fusion results are Sn=5×1016 n/sec, QDD=1.85×10-3, and neutron yield=4.0×1016 n/pulse, obtained at Ip=1.6-1.9 MA and beam energy Eb=95-103 keV, with nearly balanced co- and counter-injected beam power. Computer simulations of supershot plasmas show that typically 50%-60% of Sn arises from beam-target reactions, with the remainder divided between beam-beam and thermonuclear reactions, the thermonuclear fraction increasing with Pb. The simulations predict that QDT=0.3-0.4 would be obtained for the best present plasma conditions, if half the deuterium neutral beams were to be replaced by tritium beams. Somewhat higher values are calculated if D beams are injected into a predominantly tritium target plasma. The projected central beta of fusion alphas is 0.4%-0.6%, a level sufficient for the study of alpha-induced collective effects.

  6. Combustion and Plasma Synthesis of High-Temperature Materials

    NASA Astrophysics Data System (ADS)

    Munir, Z. A.; Holt, J. B.

    1997-04-01

    , et al.). Combustion Synthesis in the Ti-C-Ni-Al System (S. Dunmead, et al.). Combustion Synthesis Dynamics Modeling (T. Kottke, et al.). Elementary Processes in SiO2-Al Thermite-Type Reactions Activated or Induced by Mechanochemical Treatment (G. Hida & I. Lin). Combustion Synthesis of Ceramic Preforms for Molten-Metal Infiltration (D. Halverson, et al.). Combustion Characteristics of Solid-Solid Systems: Experiments and Modeling (S. Kumar, et al.). Microstructure of TiB2 Sintered by the Self-Combustion Method (K. Urabe, et al..). A Laser-Ignition Study of Gasless Reactions Using Thermography (C. Chow & J. Mohler). Shock-Induced Reaction Synthesis-Assisted Processing of Ceramics (R. Ward, et al.). Summary Assessment of the Application of SPS and Related Reaction Processing to Produce Dense Ceramics (R. Rice). Shock Consolidation of Combustion-Synthesized Ceramics (A. Niiler, et al.). High-Pressure Burning Rate of Silicon in Nitrogen (M. Costantino & J. Holt). Preparation of a TiC Single Crystal by the Floating-Zone Method from a Self-Combustion Rod (S. Otani, et al.). PLASMA AND GAS-PHASE SYNTHESIS. Thermal Plasma Synthesis of Ceramic Powders and Coatings (T. Yoshida). A Theoretical Comparison of Conventional and Hybrid RF-Plasma Reactors (J. McKelliget & N. El-Kaddah). Homogeneous Nucleation and Particle Growth in Thermal Plasma Synthesis (S. Girshick & C.-P. Chiu). Formation of Refractory Aerosol Particles (R. Flagan, et al.). Ceramic-Powder Synthesis in an Aerosol Reactor (M. Alam, et al.). Silica-Particle Formation Using the Counter-Flow Diffusion Flame Burner (J. Katz, et al.). Synthesis and Properties of Low-Carbon Boron Carbides (C. Adkins, et al.). Synthesis of Si, SiC, and Si3N4 Powders Under High Number Density Conditions (J. Haggerty & J. Flint). Rapid Preparation of Titanium and Other Transition-Metal Nitride- and Carbide Powders by a Carbo-Reduction Method Using Arc-Image Heating (M. Yoshimura, et al.). Microwave Plasma Densification of Aluminum Nitride

  7. High density plasmas and new diagnostics: An overview (invited).

    PubMed

    Celona, L; Gammino, S; Mascali, D

    2016-02-01

    One of the limiting factors for the full understanding of Electron Cyclotron Resonance Ion Sources (ECRISs) fundamental mechanisms consists of few types of diagnostic tools so far available for such compact machines. Microwave-to-plasma coupling optimisation, new methods of density overboost provided by plasma wave generation, and magnetostatic field tailoring for generating a proper electron energy distribution function, suitable for optimal ion beams formation, require diagnostic tools spanning across the entire electromagnetic spectrum from microwave interferometry to X-ray spectroscopy; these methods are going to be implemented including high resolution and spatially resolved X-ray spectroscopy made by quasi-optical methods (pin-hole cameras). The ion confinement optimisation also requires a complete control of cold electrons displacement, which can be performed by optical emission spectroscopy. Several diagnostic tools have been recently developed at INFN-LNS, including "volume-integrated" X-ray spectroscopy in low energy domain (2-30 keV, by using silicon drift detectors) or high energy regime (>30 keV, by using high purity germanium detectors). For the direct detection of the spatially resolved spectral distribution of X-rays produced by the electronic motion, a "pin-hole camera" has been developed also taking profit from previous experiences in the ECRIS field. The paper will give an overview of INFN-LNS strategy in terms of new microwave-to-plasma coupling schemes and advanced diagnostics supporting the design of new ion sources and for optimizing the performances of the existing ones, with the goal of a microwave-absorption oriented design of future machines. PMID:26931960

  8. High density plasmas and new diagnostics: An overview (invited)

    NASA Astrophysics Data System (ADS)

    Celona, L.; Gammino, S.; Mascali, D.

    2016-02-01

    One of the limiting factors for the full understanding of Electron Cyclotron Resonance Ion Sources (ECRISs) fundamental mechanisms consists of few types of diagnostic tools so far available for such compact machines. Microwave-to-plasma coupling optimisation, new methods of density overboost provided by plasma wave generation, and magnetostatic field tailoring for generating a proper electron energy distribution function, suitable for optimal ion beams formation, require diagnostic tools spanning across the entire electromagnetic spectrum from microwave interferometry to X-ray spectroscopy; these methods are going to be implemented including high resolution and spatially resolved X-ray spectroscopy made by quasi-optical methods (pin-hole cameras). The ion confinement optimisation also requires a complete control of cold electrons displacement, which can be performed by optical emission spectroscopy. Several diagnostic tools have been recently developed at INFN-LNS, including "volume-integrated" X-ray spectroscopy in low energy domain (2-30 keV, by using silicon drift detectors) or high energy regime (>30 keV, by using high purity germanium detectors). For the direct detection of the spatially resolved spectral distribution of X-rays produced by the electronic motion, a "pin-hole camera" has been developed also taking profit from previous experiences in the ECRIS field. The paper will give an overview of INFN-LNS strategy in terms of new microwave-to-plasma coupling schemes and advanced diagnostics supporting the design of new ion sources and for optimizing the performances of the existing ones, with the goal of a microwave-absorption oriented design of future machines.

  9. Patients with MCI and N400 or P600 abnormalities are at very high risk for conversion to dementia

    PubMed Central

    Olichney, J.M.; Taylor, J.R.; Gatherwright, J.; Salmon, D.P.; Bressler, A.J.; Kutas, M.; Iragui-Madoz, V.J.

    2011-01-01

    Objective We sought cognitive event-related potential (ERP) biomarkers of disease progression and subsequent conversion to dementia in mild cognitive impairment (MCI). Background Two ERP components, the P600 and N400, are sensitive to abnormal episodic/declarative memory and semantic processing. When congruous category-exemplars are repeated, smaller P600s (relative to initial presentation) are normally elicited. Repetitions of semantically incongruous words yield smaller N400 amplitude. In mild Alzheimer disease (AD), abnormalities of both the N400 and P600 repetition effects are present, suggesting a wide-spread failure of synaptic plasticity. Methods Patients with amnestic MCI (n = 32) were longitudinally studied annually with an ERP paradigm in which semantically congruous (50%) and incongruous target words are repeated 10 to 140 seconds after initial presentation. ERP data were analyzed to contrast MCI-to-AD converters (within 3 years) vs nonconverters, using split-plot analyses of variance. Results A statistically significant P600 congruous word repetition effect was found only in the nonconverter group (F = 9.9, p = 0.005 vs MCI converters). This effect correlated with verbal memory measures. Repetition of incongruous words produced a significant N400 amplitude attenuation (across right-hemisphere sites) in nonconverters, but not in converters. Patients with MCI with abnormal/reduced N400 or P600 word repetition effects had an 87 to 88% likelihood of dementia within 3 years while those with normal/spared N400 and P600 repetition effects had only an 11 to 27% likelihood. Conclusions Abnormalities of the P600 or N400 in mild cognitive impairment are associated with an increased risk of subsequent conversion to Alzheimer disease (AD). These event-related potential components may offer useful biomarkers for the detection and staging of very early AD. PMID:18077800

  10. Instrument technology for magnetosphere plasma imaging from high Earth orbit. Design of a radio plasma sounder

    NASA Technical Reports Server (NTRS)

    Haines, D. Mark; Reinisch, Bodo W.

    1995-01-01

    The use of radio sounding techniques for the study of the ionospheric plasma dates back to G. Briet and M. A. Tuve in 1926. Ground based swept frequency sounders can monitor the electron number density (N(sub e)) as a function of height (the N(sub e) profile). These early instruments evolved into a global network that produced high-resolution displays of echo time delay vs frequency on 35-mm film. These instruments provided the foundation for the success of the International Geophysical Year (1958). The Alouette and International Satellites for Ionospheric Studies (ISIS) programs pioneered the used of spaceborne, swept frequency sounders to obtain N(sub e) profiles of the topside of the ionosphere, from a position above the electron density maximum. Repeated measurements during the orbit produced an orbital plane contour which routinely provided density measurements to within 10%. The Alouette/ISIS experience also showed that even with a high powered transmitter (compared to the low power sounder possible today) a radio sounder can be compatible with other imaging instruments on the same satellite. Digital technology was used on later spacecraft developed by the Japanese (the EXOS C and D) and the Soviets (Intercosmos 19 and Cosmos 1809). However, a full coherent pulse compression and spectral integrating capability, such as exist today for ground-based sounders (Reinisch et al., 1992), has never been put into space. NASA's 1990 Space Physics Strategy Implementation Study "The NASA Space Physics Program from 1995 to 2010" suggested using radio sounders to study the plasmasphere and the magnetopause and its boundary layers (Green and Fung, 1993). Both the magnetopause and plasmasphere, as well as the cusp and boundary layers, can be observed by a radio sounder in a high-inclination polar orbit with an apogee greater than 6 R(sub e) (Reiff et al., 1994; Calvert et al., 1995). Magnetospheric radio sounding from space will provide remote density measurements of

  11. External control of ion waves in a plasma by high frequency fields

    DOEpatents

    Kaw, P.K.; Dawson, J.M.

    1973-12-18

    An apparatus and method are described for stabilizing plasma instabilities, in a magnetically confined plasma column by transmitting into the plasma high frequency electromagnetic waves at a frequency close to the electron plasma frequency. The said frequencies, e.g., are between the plasma frequency and 1.5 times the plasma frequency at a power level below the level for producing parametric instabilities in a plasma having temperatures from below 10 eV to about 10 keV or more, at densities from below 10/sup 13/ to above 10/sup 18/ particles/cm/sup 3/. (Official Gazette)

  12. Research on plasma-puff initiation of high Coulomb transfer switches

    NASA Technical Reports Server (NTRS)

    Venable, Demetrius D.; Han, Kwang S.

    1993-01-01

    The plasma-puff triggering mechanism based on hypocycloidal pinch geometry was investigated to determine the optimal operating conditions for an azimuthally uniform surface flashover which initiates plasma-puff under wide ranges of fill gas pressures of Ar, He and N2. Research is presented and resulting conference papers are attached. These papers include 'Characteristics of Plasma-Puff Trigger for an Inverse-Pinch Plasma Switch'; 'Ultra-High-Power Plasma Switch INPUTS for Pulse Power Systems'; 'Characteristics of Switching Plasma in an Inverse-Pinch Switch'; 'Comparative Study of INPIStron and Spark Gap'; and 'INPIStron Switched Pulsed Power for Dense Plasma Pinches.'

  13. High frequency drift instabilities in a dusty plasma

    NASA Technical Reports Server (NTRS)

    Rosenberg, M.; Krall, N. A.

    1994-01-01

    High frequency drift instabilities with omega(sub ce) much greater than omega which is greater than omega(sub ci) are investigated in a dusty magnetized plasma in which locally there is an electron density gradient which is opposite in sign to a dust density gradient. Two different equilibria are considered, characterized by rho(sub d) greater than L(sub d) and less than L(sub d), where rho(sub d) is the dust gyroradius and L(sub nd) is the dust density scale length. Possible application to Saturn's F-ring is discussed.

  14. High current multicharged metal ion source using high power gyrotron heating of vacuum arc plasma.

    PubMed

    Vodopyanov, A V; Golubev, S V; Khizhnyak, V I; Mansfeld, D A; Nikolaev, A G; Oks, E M; Savkin, K P; Vizir, A V; Yushkov, G Yu

    2008-02-01

    A high current, multi charged, metal ion source using electron heating of vacuum arc plasma by high power gyrotron radiation has been developed. The plasma is confined in a simple mirror trap with peak magnetic field in the plug up to 2.5 T, mirror ratio of 3-5, and length variable from 15 to 20 cm. Plasma formed by a cathodic vacuum arc is injected into the trap either (i) axially using a compact vacuum arc plasma gun located on axis outside the mirror trap region or (ii) radially using four plasma guns surrounding the trap at midplane. Microwave heating of the mirror-confined, vacuum arc plasma is accomplished by gyrotron microwave radiation of frequency 75 GHz, power up to 200 kW, and pulse duration up to 150 micros, leading to additional stripping of metal ions by electron impact. Pulsed beams of platinum ions with charge state up to 10+, a mean charge state over 6+, and total (all charge states) beam current of a few hundred milliamperes have been formed. PMID:18315170

  15. High current multicharged metal ion source using high power gyrotron heating of vacuum arc plasma

    SciTech Connect

    Vodopyanov, A. V.; Golubev, S. V.; Khizhnyak, V. I.; Mansfeld, D. A.; Nikolaev, A. G.; Oks, E. M.; Savkin, K. P.; Vizir, A. V.; Yushkov, G. Yu.

    2008-02-15

    A high current, multi charged, metal ion source using electron heating of vacuum arc plasma by high power gyrotron radiation has been developed. The plasma is confined in a simple mirror trap with peak magnetic field in the plug up to 2.5 T, mirror ratio of 3-5, and length variable from 15 to 20 cm. Plasma formed by a cathodic vacuum arc is injected into the trap either (i) axially using a compact vacuum arc plasma gun located on axis outside the mirror trap region or (ii) radially using four plasma guns surrounding the trap at midplane. Microwave heating of the mirror-confined, vacuum arc plasma is accomplished by gyrotron microwave radiation of frequency 75 GHz, power up to 200 kW, and pulse duration up to 150 {mu}s, leading to additional stripping of metal ions by electron impact. Pulsed beams of platinum ions with charge state up to 10+, a mean charge state over 6+, and total (all charge states) beam current of a few hundred milliamperes have been formed.

  16. High-field plasma acceleration in a high-ionization-potential gas

    NASA Astrophysics Data System (ADS)

    Corde, S.; Adli, E.; Allen, J. M.; An, W.; Clarke, C. I.; Clausse, B.; Clayton, C. E.; Delahaye, J. P.; Frederico, J.; Gessner, S.; Green, S. Z.; Hogan, M. J.; Joshi, C.; Litos, M.; Lu, W.; Marsh, K. A.; Mori, W. B.; Vafaei-Najafabadi, N.; Walz, D.; Yakimenko, V.

    2016-06-01

    Plasma accelerators driven by particle beams are a very promising future accelerator technology as they can sustain high accelerating fields over long distances with high energy efficiency. They rely on the excitation of a plasma wave in the wake of a drive beam. To generate the plasma, a neutral gas can be field-ionized by the head of the drive beam, in which case the distance of acceleration and energy gain can be strongly limited by head erosion. Here we overcome this limit and demonstrate that electrons in the tail of a drive beam can be accelerated by up to 27 GeV in a high-ionization-potential gas (argon), boosting their initial 20.35 GeV energy by 130%. Particle-in-cell simulations show that the argon plasma is sustaining very high electric fields, of ~150 GV m-1, over ~20 cm. The results open new possibilities for the design of particle beam drivers and plasma sources.

  17. High-field plasma acceleration in a high-ionization-potential gas

    PubMed Central

    Corde, S.; Adli, E.; Allen, J. M.; An, W.; Clarke, C. I.; Clausse, B.; Clayton, C. E.; Delahaye, J. P.; Frederico, J.; Gessner, S.; Green, S. Z.; Hogan, M. J.; Joshi, C.; Litos, M.; Lu, W.; Marsh, K. A.; Mori, W. B.; Vafaei-Najafabadi, N.; Walz, D.; Yakimenko, V.

    2016-01-01

    Plasma accelerators driven by particle beams are a very promising future accelerator technology as they can sustain high accelerating fields over long distances with high energy efficiency. They rely on the excitation of a plasma wave in the wake of a drive beam. To generate the plasma, a neutral gas can be field-ionized by the head of the drive beam, in which case the distance of acceleration and energy gain can be strongly limited by head erosion. Here we overcome this limit and demonstrate that electrons in the tail of a drive beam can be accelerated by up to 27 GeV in a high-ionization-potential gas (argon), boosting their initial 20.35 GeV energy by 130%. Particle-in-cell simulations show that the argon plasma is sustaining very high electric fields, of ∼150 GV m−1, over ∼20 cm. The results open new possibilities for the design of particle beam drivers and plasma sources. PMID:27312720

  18. High-field plasma acceleration in a high-ionization-potential gas.

    PubMed

    Corde, S; Adli, E; Allen, J M; An, W; Clarke, C I; Clausse, B; Clayton, C E; Delahaye, J P; Frederico, J; Gessner, S; Green, S Z; Hogan, M J; Joshi, C; Litos, M; Lu, W; Marsh, K A; Mori, W B; Vafaei-Najafabadi, N; Walz, D; Yakimenko, V

    2016-01-01

    Plasma accelerators driven by particle beams are a very promising future accelerator technology as they can sustain high accelerating fields over long distances with high energy efficiency. They rely on the excitation of a plasma wave in the wake of a drive beam. To generate the plasma, a neutral gas can be field-ionized by the head of the drive beam, in which case the distance of acceleration and energy gain can be strongly limited by head erosion. Here we overcome this limit and demonstrate that electrons in the tail of a drive beam can be accelerated by up to 27 GeV in a high-ionization-potential gas (argon), boosting their initial 20.35 GeV energy by 130%. Particle-in-cell simulations show that the argon plasma is sustaining very high electric fields, of ∼150 GV m(-1), over ∼20 cm. The results open new possibilities for the design of particle beam drivers and plasma sources. PMID:27312720

  19. High-field plasma acceleration in a high-ionization-potential gas

    DOE PAGESBeta

    Corde, S.; Adli, E.; Allen, J. M.; An, W.; Clarke, C. I.; Clausse, B.; Clayton, C. E.; Delahaye, J. P.; Frederico, J.; Gessner, S.; et al

    2016-06-17

    Plasma accelerators driven by particle beams are a very promising future accelerator technology as they can sustain high accelerating fields over long distances with high energy efficiency. They rely on the excitation of a plasma wave in the wake of a drive beam. To generate the plasma, a neutral gas can be field-ionized by the head of the drive beam, in which case the distance of acceleration and energy gain can be strongly limited by head erosion. In our research, we overcome this limit and demonstrate that electrons in the tail of a drive beam can be accelerated by upmore » to 27 GeV in a high-ionization-potential gas (argon), boosting their initial 20.35 GeV energy by 130%. Particle-in-cell simulations show that the argon plasma is sustaining very high electric fields, of ~150 GV m-1, over ~20 cm. Lastly, the results open new possibilities for the design of particle beam drivers and plasma sources.« less

  20. Morphological abnormalities in elasmobranchs.

    PubMed

    Moore, A B M

    2015-08-01

    A total of 10 abnormal free-swimming (i.e., post-birth) elasmobranchs are reported from The (Persian-Arabian) Gulf, encompassing five species and including deformed heads, snouts, caudal fins and claspers. The complete absence of pelvic fins in a milk shark Rhizoprionodon acutus may be the first record in any elasmobranch. Possible causes, including the extreme environmental conditions and the high level of anthropogenic pollution particular to The Gulf, are briefly discussed. PMID:25903257

  1. Proposed method for high-speed plasma density measurement in proton-driven plasma wakefield acceleration

    SciTech Connect

    Tarkeshian, R.; Reimann, O.; Muggli, P.

    2012-12-21

    Recently a proton-bunch-driven plasma wakefield acceleration experiment using the CERN-SPS beam was proposed. Different types of plasma cells are under study, especially laser ionization, plasma discharge, and helicon sources. One of the key parameters is the spatial uniformity of the plasma density profile along the cell that has to be within < 1% of the nominal density (6 Multiplication-Sign 10{sup 14} cm{sup -3}). Here a setup based on a photomixing concept is proposed to measure the plasma cut-off frequency and determine the plasma density.

  2. High-gradient plasma-wakefield acceleration with two subpicosecond electron bunches.

    PubMed

    Kallos, Efthymios; Katsouleas, Tom; Kimura, Wayne D; Kusche, Karl; Muggli, Patric; Pavlishin, Igor; Pogorelsky, Igor; Stolyarov, Daniil; Yakimenko, Vitaly

    2008-02-22

    A plasma-wakefield experiment is presented where two 60 MeV subpicosecond electron bunches are sent into a plasma produced by a capillary discharge. Both bunches are shorter than the plasma wavelength, and the phase of the second bunch relative to the plasma wave is adjusted by tuning the plasma density. It is shown that the second bunch experiences a 150 MeV/m loaded accelerating gradient in the wakefield driven by the first bunch. This is the first experiment to directly demonstrate high-gradient, controlled acceleration of a short-pulse trailing electron bunch in a high-density plasma. PMID:18352561

  3. Spectroscopic Non-LTE Modeling of Highly Charged Gold Plasma

    NASA Astrophysics Data System (ADS)

    Dasgupta, A.; Ouart, N. D.; Giuliani, J. L.; Obenschain, S. P.; Clark, R. W.; Aglitskiy, Y.

    2013-10-01

    An X-ray spectrometer is under development at the Naval Research Laboratory (NRL) to investigate emissions from gold targets irradiated by the NIKE KrF facility. This effort is in support of the indirect drive campaign on the National Ignition Facility (NIF). To analyze and interpret the NIKE experimental spectra, we are theoretically exploring line emissions from a gold plasma in the M-band, i.e., 1.5 to 3.5 keV. We employ a detailed Non-LTE atomic model for ions near Ni-like gold by including an adequate number of configurations to obtain spectroscopic details in this range. The atomic states are coupled both collisionally and radiatively, including all dominant atomic processes that have significant contributions to the ionization and emitted synthetic spectra. In particular, we will investigate the effect of dielectronic recombination, which can have a dominant effect on level populations for highly ionized high Z plasmas. Since the radiation field can affect level populations through photoionization and photoexcitation, our collisional-radiative model will include non-local radiation transport. The line shapes of the strong overlapping lines will be resolved by a multifrequency radiation transport method. Synthetic spectra with radiation transport, including resonant photo-pumping, will be generated for realistic densities and temperatures to compare with the NIKE data. Work supported by DOE/NNSA.

  4. The interchange instability in high-latitude plasma blobs

    SciTech Connect

    Chaturvedi, P.K.; Huba, J.D. )

    1987-04-01

    The stability of high-latitude plasma density enhancements (blobs) is analyzed with regard to the interchange mode (driven by neutral wind or equilibrium transverse electric field acting on the density gradient at the walls of the blobs). The effects arising from the finite parallel length of the blobs along the magnetic field lines are included in the analysis. Plasma regions of differing collisionalities, to which the blobs extend in altitude, are considered. The authors find that the finite parallel blob size results in a modest reduction in the growth rates of the small ({approx lt}1 km) and intermediate (1-10 km) scale sizes but severely reduces the growth rates for the large scale sizes (> 10 km) for the observed parallel blob lengths ({approximately}300-600 km). Further, it is found that the instability growth rates show a moderate reduction at higher altitudes (where ion-inertial effects may be dominant over the ion-neutral collisional effects). Thus the E{times} B instability is considered a plausible candidate for the scintillation-causing irregularities (1-10 km) associated with the high-latitude blobs.

  5. Interchange instability in high-latitude plasma blobs. Memorandum report

    SciTech Connect

    Chaturvedi, P.K.; Huba, J.D.

    1986-12-30

    The stability of high-latitude plasma-density enhancements (blobs) is analyzed with regard to the interchange model (driven by a neutral wind or transverse electric field acting on the density gradient at the walls of the blobs). The effects arising from the finite parallel length of the blobs along the magnetic field lines are included in the analysis. Plasma regions of differing collisionalities, to which the blobs extend in altitude, are considered. It was found that the finite-parallel blob size results in a modest reduction in the growth rates of the small somewhat < 1 km) and intermediate (1-10 km) scale sizes, but severely reduces the growth rates, for the large scale sizes (> 10 kms) for the observed parallel blob lengths (approx. 300-600 kms). Further, it is found that the instability growth rates show a moderate reduction at higher altitudes (where ion-inertial effects may be dominant over the ion-neutral collisional effects). Thus, the E x B instability is considered a plausible candidate for the scintillation causing irregularities (1-10 kms) associated with the high-latitude blobs.

  6. High efficiency ICF driver employing magnetically confined plasma rings

    SciTech Connect

    Meeker, D.J.; Hammer, J.H.; Hartman, C.W.

    1985-03-04

    We discuss the possibility of achieving energy, power and power density necessary for ICF by magnetically accelerating plasma confined by a compact torus (CT) field configuration. The CT, which consists of a dipole (poloidal) field and imbedded toroidal field formed by force-free, plasma current, is compressed and accelerated between coaxial electrodes by B/sub THETA/ fields as in a coaxial railgun. Compression and acceleration over several meters by a 9.4 MJ capacitor bank is predicted to give a 5.7 cm radius, 0.001 gm CT 5 MJ kinetic energy (10/sup 7/ m/sec). Transport and focussing several meters by a disposable lithium pipe across the containment vessel is predicted to bring 4.8 MJ into the pellet region in 0.5 cm/sup 2/ area in 0.3 ns. The high efficiency (approx.50%) and high energy delivery of the CT accelerator could lead to low cost, few hundred MW power plants that are economically viable.

  7. High-Q plasmas in the TFTR tokamak

    SciTech Connect

    Jassby, D.L.; Bell, M.G.; Bitter, M.; Boivin, R.; Bretz, N.L.; Budny, R.V.; Dylla, H.F.; Efthimion, P.C.; Fredrickson, E.D.; Hawryluk, R.J.; Hill, K.W.; Hosea, J.; Hsuan, H.; Janos, A.C.; Jobes, F.C.; Johnson, D.W.; Johnson, L.C.; Kamperschroer, J.; Kieras-Phillips, C.; Kilpatrick, S.J.; LaMarche, P.H.; LeBlanc, B.; Mansfield, D.K.; McCune, D.C.; McGuire, K.M.; Meade, D.M.; Medley, S.S.; Mikkelsen, D.R.; Mueller, D.; Owens, D

    1991-05-01

    In the Tokamak Fusion Test Reactor, the highest neutron source strength S{sub n} and D-D fusion power gain Q{sub DD} are realized in the neutral-beam fueled and heated supershot'' regime that occurs after extensive wall conditioning to minimize recycling. For the best supershots, S{sub n} increases approximately as P{sub b}{sup 1.8}. The highest-Q shots are characterized by high T{sub e}, T{sub i}, and stored energy highly peaked density profiles, broad T{sub e} profiles, and lower Z{sub eff}. Replacement of critical areas of the graphite limiter tiles with carbon-fiber composite tiles, and improved alignment with the plasma, have mitigated the carbon bloom.'' Wall conditioning by lithium pellet injection prior to the beam pulse reduces carbon influx and particle recycling. Empirically, Q{sub DD} increases with decreasing pre-injection carbon radiation, and increases strongly with density peakedness during the beam pulse. To date the best fusion results are S{sub n} = 5 {times} 10{sup 16} n/s, Q{sub DD} = 1.85 {times} 10{sup {minus}3}, and neutron yield = 4.0 {times} 10{sup 16} n/pulse, obtained at I{sub p} = 1.6 to 1.9 MA and beam energy E{sub b} = 95 to 103 keV, with nearly balanced co- and counter-injected beam power. Computer simulations of supershot plasmas show that typically 50--60% of S{sub n} arises from beam-target reactions, with the remainder divided between beam-beam and thermonuclear reactions, the thermonuclear fraction increasing with P{sub b}. The simulations predict that Q{sub DT} = 0.3 to 0.4 would be obtained for the best present plasma conditions, if half the deuterium neutral beams were to be replaced by tritium beams. Somewhat higher values are calculated if D beams are injected into a predominantly tritium target plasma. The projected central beta of fusion alphas is 0.4--0.6%, a level sufficient for the study of alpha-induced collective effects. 16 refs., 8 figs., 3 tabs.

  8. High-order harmonic generation in carbon-nanotube-containing plasma plumes

    SciTech Connect

    Ganeev, R. A.; Naik, P. A.; Singhal, H.; Chakera, J. A.; Kumar, M.; Joshi, M. P.; Srivastava, A. K.; Gupta, P. D.

    2011-01-15

    High-order harmonic generation (HHG) in carbon-nanotube (CNT)-containing plasma plumes has been demonstrated. Various targets were ablated to produce the plasma plumes containing nanotubes for the HHG in these media. Harmonics up to the 29th order were generated. Odd and even harmonics were generated using a two-color pump. The integrity of CNTs within the plasma plume, indicating nanotubes as the source of high-order harmonics, was confirmed by structural studies of plasma debris.

  9. High density plasma gun generates plasmas at 190 kilometers per second

    NASA Technical Reports Server (NTRS)

    Espy, P. N.

    1971-01-01

    Gun has thin metal foil disc which positions or localizes gas to be ionized during electrical discharge cycle, overcoming major limiting factor in obtaining such plasmas. Expanding plasma front travels at 190 km/sec, compared to plasmas of 50 to 60 km/sec previously achieved.

  10. Runaway electron dynamics in tokamak plasmas with high impurity content

    SciTech Connect

    Martín-Solís, J. R.; Loarte, A.; Lehnen, M.

    2015-09-15

    The dynamics of high energy runaway electrons is analyzed for plasmas with high impurity content. It is shown that modified collision terms are required in order to account for the collisions of the relativistic runaway electrons with partially stripped impurity ions, including the effect of the collisions with free and bound electrons, as well as the scattering by the full nuclear and the electron-shielded ion charge. The effect of the impurities on the avalanche runaway growth rate is discussed. The results are applied, for illustration, to the interpretation of the runaway electron behavior during disruptions, where large amounts of impurities are expected, particularly during disruption mitigation by massive gas injection. The consequences for the electron synchrotron radiation losses and the resulting runaway electron dynamics are also analyzed.

  11. Runaway electron dynamics in tokamak plasmas with high impurity content

    NASA Astrophysics Data System (ADS)

    Martín-Solís, J. R.; Loarte, A.; Lehnen, M.

    2015-09-01

    The dynamics of high energy runaway electrons is analyzed for plasmas with high impurity content. It is shown that modified collision terms are required in order to account for the collisions of the relativistic runaway electrons with partially stripped impurity ions, including the effect of the collisions with free and bound electrons, as well as the scattering by the full nuclear and the electron-shielded ion charge. The effect of the impurities on the avalanche runaway growth rate is discussed. The results are applied, for illustration, to the interpretation of the runaway electron behavior during disruptions, where large amounts of impurities are expected, particularly during disruption mitigation by massive gas injection. The consequences for the electron synchrotron radiation losses and the resulting runaway electron dynamics are also analyzed.

  12. Numerical analysis on plasma characteristics of high power plasma torch of hollow electrode type for waste treatment

    SciTech Connect

    Hur, M.; Kang, K.D.; Hong, S.H.

    1997-12-31

    In this study, the plasma characteristics of a high power nontransferred plasma torch with hollow electrodes are investigated in the atmospheric condition by analyzing the distributions of plasma temperature, velocity and current density. Typical assumptions of steady state, axisymmetry, local thermodynamic equilibrium (LTE) and optically thin plasma are adopted in a two-dimensional magnetohydrodynamic (MHD) modeling of thermal plasma with a special treatment of arc spot positions. A control volume method and the modified SIMPLER algorithm are used for solving the governing equations numerically, i.e., conservation equations of mass, momentum, and energy along with the equations describing the {Kappa}-{var_epsilon} model for turbulence and the current continuity for arc discharge. The distributions of plasma temperature, velocity, and current density are calculated in various operation conditions such as gas species, gas flowrate, input current, and electrode geometry. The calculated results of plasma characteristics in various operations can be useful to determine the design parameters of the high power plasma torch of hollow electrode type for incinerating the hospital and municipal solid wastes.

  13. Abnormal pressure in hydrocarbon environments

    USGS Publications Warehouse

    Law, B.E.; Spencer, C.W.

    1998-01-01

    Abnormal pressures, pressures above or below hydrostatic pressures, occur on all continents in a wide range of geological conditions. According to a survey of published literature on abnormal pressures, compaction disequilibrium and hydrocarbon generation are the two most commonly cited causes of abnormally high pressure in petroleum provinces. In young (Tertiary) deltaic sequences, compaction disequilibrium is the dominant cause of abnormal pressure. In older (pre-Tertiary) lithified rocks, hydrocarbon generation, aquathermal expansion, and tectonics are most often cited as the causes of abnormal pressure. The association of abnormal pressures with hydrocarbon accumulations is statistically significant. Within abnormally pressured reservoirs, empirical evidence indicates that the bulk of economically recoverable oil and gas occurs in reservoirs with pressure gradients less than 0.75 psi/ft (17.4 kPa/m) and there is very little production potential from reservoirs that exceed 0.85 psi/ft (19.6 kPa/m). Abnormally pressured rocks are also commonly associated with unconventional gas accumulations where the pressuring phase is gas of either a thermal or microbial origin. In underpressured, thermally mature rocks, the affected reservoirs have most often experienced a significant cooling history and probably evolved from an originally overpressured system.

  14. High energy density plasma science with an ultrarelativistic electron beam

    NASA Astrophysics Data System (ADS)

    Joshi, C.; Blue, B.; Clayton, C. E.; Dodd, E.; Huang, C.; Marsh, K. A.; Mori, W. B.; Wang, S.; Hogan, M. J.; O'Connell, C.; Siemann, R.; Watz, D.; Muggli, P.; Katsouleas, T.; Lee, S.

    2002-05-01

    An intense, high-energy electron or positron beam can have focused intensities rivaling those of today's most powerful laser beams. For example, the 5 ps (full-width, half-maximum), 50 GeV beam at the Stanford Linear Accelerator Center (SLAC) at 1 kA and focused to a 3 micron rms spot size gives intensities of >1020 W/cm-2 at a repetition rate of >10 Hz. Unlike a ps or fs laser pulse which interacts with the surface of a solid target, the particle beam can readily tunnel through tens of cm of steel. However, the same particle beam can be manipulated quite effectively by a plasma that is a million times less dense than air! This is because of the incredibly strong collective fields induced in the plasma by the Coulomb force of the beam. The collective fields in turn react back onto the beam leading to many clearly observable phenomena. The beam paraticles can be: (1) Deflected leading to focusing, defocusing, or even steering of the beam; (2) undulated causing the emission of spontaneous betatron x-ray radiation and; (3) accelerated or decelerated by the plasma fields. Using the 28.5 GeV electron beam from the SLAC linac a series of experiments have been carried out that demonstrate clearly many of the above mentioned effects. The results can be compared with theoretical predictions and with two-dimensional and three-dimensional, one-to-one, particle-in-cell code simulations. These phenomena may have practical applications in future technologies including optical elements in particle beam lines, synchrotron light sources, and ultrahigh gradient accelerators.

  15. Plasma BDNF and PDGF-AA levels are associated with high TCD velocity and stroke in children with sickle cell anemia

    PubMed Central

    Hyacinth, Hyacinth I.; Gee, Beatrice E.; Adamkiewicz, Thomas V.; Adams, Robert J.; Kutlar, Abdullah; Stiles, Jonathan K.; Hibbert, Jacqueline M.

    2012-01-01

    Sickle cell anemia (SCA) associated cerebrovascular disease includes vascular remodeling, abnormal cerebral blood flow (CBF) and infarction. We studied the relationships between plasma brain derived neurotropic factor (BDNF), platelet derived growth factors (PDGF-AA and -AB/BB) and high trans-cranial Doppler (TCD) velocity, an indication of CBF velocity. Baseline plasma samples from 39 children (19 SCA with abnormal/high TCD [SATCD], 13 SCA with normal TCD [SNTCD] and 7 healthy non-SCA), were assayed for BDNF, PDGF-AA and – AB/BB plus 11 other cytokines. The sensitivity, specificity and usefulness of these biomarkers for prediction of stroke incidence was investigated. All subject groups were of similar age and gender distribution. Mean BDNF was significantly higher among SATCD than SNTCD (p=0.004) as was mean PDGF-AA (p=0.001). Similarly, mean PDGF-AA was higher among SCA subjects who developed stroke than for those who did not (p=0.012). Elevated BDNF and PDGF-AA were both associated with severity of anemia. Elevated BDNF and PDGF-AA were good predictors of the presence of abnormally high CBF velocity, and PDGF-AA predicted stroke development. Stroke incidence and high TCD velocity were associated with elevated BDNF and PDGF-AA. These findings suggest a role for BDNF and PDGF-AA in the patho-physiological mechanism of cerebrovascular disease in SCA. PMID:22704695

  16. Genotype Distribution of Human Papillomavirus among Women with Cervical Cytological Abnormalities or Invasive Squamous Cell Carcinoma in a High-Incidence Area of Esophageal Carcinoma in China

    PubMed Central

    Wang, Yuanyuan; Wang, Shaohong; Shen, Jinhui; Peng, Yanyan; Chen, Lechuan; Mai, Ruiqin

    2016-01-01

    Data of HPV genotype including 16 high-risk HPV (HR-HPV) and 4 low-risk HPV from 38,397 women with normal cytology, 1341 women with cervical cytology abnormalities, and 223 women with ISCC were retrospectively evaluated by a hospital-based study. The prevalence of high-risk HPV (HR-HPV) was 6.51%, 41.83%, and 96.86% in women with normal cytology, cervical cytology abnormalities, and ISCC, respectively. The three most common HPV types were HPV-52 (1.76%), HPV-16 (1.28%), and HPV-58 (0.97%) in women with normal cytology, whereas the most prevalent HPV type was HPV-16 (16.85%), followed by HPV-52 (9.55%) and HPV-58 (7.83%) in women with cervical cytology abnormalities. Specifically, HPV-16 had the highest frequency in ASC-H (24.16%, 36/149) and HSIL (35.71%, 110/308), while HPV-52 was the most common type in ASC-US (8.28%, 53/640) and LSIL (16.80%, 41/244). HPV-16 (75.78%), HPV18 (10.31%), and HPV58 (9.87%) were the most common types in women with ISCC. These data might contribute to increasing the knowledge of HPV epidemiology and providing the guide for vaccine selection for women in Shantou. PMID:27610364

  17. Genotype Distribution of Human Papillomavirus among Women with Cervical Cytological Abnormalities or Invasive Squamous Cell Carcinoma in a High-Incidence Area of Esophageal Carcinoma in China.

    PubMed

    Wang, Yuanyuan; Wang, Shaohong; Shen, Jinhui; Peng, Yanyan; Chen, Lechuan; Mai, Ruiqin; Zhang, Guohong

    2016-01-01

    Data of HPV genotype including 16 high-risk HPV (HR-HPV) and 4 low-risk HPV from 38,397 women with normal cytology, 1341 women with cervical cytology abnormalities, and 223 women with ISCC were retrospectively evaluated by a hospital-based study. The prevalence of high-risk HPV (HR-HPV) was 6.51%, 41.83%, and 96.86% in women with normal cytology, cervical cytology abnormalities, and ISCC, respectively. The three most common HPV types were HPV-52 (1.76%), HPV-16 (1.28%), and HPV-58 (0.97%) in women with normal cytology, whereas the most prevalent HPV type was HPV-16 (16.85%), followed by HPV-52 (9.55%) and HPV-58 (7.83%) in women with cervical cytology abnormalities. Specifically, HPV-16 had the highest frequency in ASC-H (24.16%, 36/149) and HSIL (35.71%, 110/308), while HPV-52 was the most common type in ASC-US (8.28%, 53/640) and LSIL (16.80%, 41/244). HPV-16 (75.78%), HPV18 (10.31%), and HPV58 (9.87%) were the most common types in women with ISCC. These data might contribute to increasing the knowledge of HPV epidemiology and providing the guide for vaccine selection for women in Shantou. PMID:27610364

  18. High-Intensity High-order Harmonics Generated from Low-Density Plasma

    SciTech Connect

    Ozaki, T.; Bom, L. B. Elouga; Abdul-Hadi, J.; Ganeev, R. A.; Haessler, S.; Salieres, P.

    2009-07-25

    We study the generation of high-order harmonics from lowly ionized plasma, using the 10 TW, 10 Hz laser of the Advanced Laser Light Source (ALLS). We perform detailed studies on the enhancement of a single order of the high-order harmonic spectrum generated in plasma using the fundamental and second harmonic of the ALLS beam line. We observe quasi-monochromatic harmonics for various targets, including Mn, Cr, Sn, and In. We identify most of the ionic/neutral transitions responsible for the enhancement, which all have strong oscillator strengths. We demonstrate intensity enhancements of the 13th, 17th, 29th, and 33rd harmonics from these targets using the 800 nm pump laser and varying its chirp. We also characterized the attosecond nature of such plasma harmonics, measuring attosecond pulse trains with 360 as duration for chromium plasma, using the technique of 'Reconstruction of Attosecond Beating by Interference of Two-photon Transitions'(RABBIT). These results show that plasma harmonics are intense source of ultrashort coherent soft x-rays.

  19. Vortices, Reconnection and Turbulence in High Electron-Beta Plasmas

    SciTech Connect

    Stenzel, R. L.

    2004-08-31

    Plasmas in which the kinetic energy exceeds the magnetic energy by a significant factor are common in space and in the laboratory. Such plasmas can convect magnetic fields and create null points in whose vicinity first the ions become unmagnetized, then the electrons. This project focuses on the detailed study of the transition regime of these plasmas.

  20. THE IRON OPACITY PROJECT: High-Energy-Density Plasma Opacities

    NASA Astrophysics Data System (ADS)

    Palay, E.; Orban, C.; Nahar, S.; Pradhan, A.; Pinnsonoault, M.; Bailey, J.

    2013-05-01

    Opacity governs radiation flow in plasma sources. Accurate opacities are needed to model unobservable laboratory and astrophysical conditions. High-energy-density (HED) plasma conditions prevalent in stellar interiors can now be recreated in the laboratory. The Z-pinch fusion device at the Sandia National Lab can reproduce temperatures and densities near the boundary where radiation transport changes from diffusion to convection inside the Sun. To benchmark theoretical opacities experiments are essential to resolve the outstanding discrepancy in solar abundances. The most common volatile elements C, N, O, Ne, etc. have been spectroscopically measured to be up to 50% lower than the standard abundances. This introduces conflict in the derived values of basic solar parameters such as the radiation/convection boundary, sound speed, and the primordial He abundance with precisely measured oscillations of the Sun through Helioseismology. A potential solution is increment of stellar opacities, which has inverse but complex relation with abundacnes, at least 30%. New iron opacity calculations include hitherto neglected atomic physics of fine structure and resonances which are largely treated as lines in existing opacities calculations. Preliminary results on radiative transitions in Ne Partial support: DOE,NSF.

  1. Plasma-depleted holes, waves, and energized particles from high-altitude explosive plasma perturbation experiments

    NASA Technical Reports Server (NTRS)

    Wescott, E. M.; Stenbaek-Nielsen, H. C.; Hallinan, T.; Deehr, C.; Romick, J.; Olson, J.; Kelley, M. C.; Pfaff, R.; Torbert, R. B.; Newell, P.

    1985-01-01

    The results of high-explosive shaped charge experiments King Crab and Bubble Machines I and II, intended to perturb the ambient plasma and magnetic field, are discussed. The instrumentation was flown above an altitude of 460 km in March 1980 and 1981 and comprised a single-axis dipole electric field detector, a fixed bias cylindrical Langmuir probe, a three-axis attitude magnetometer, and curved plated energetic ion and electron electrostatic analyzer. Among the effects of the explosion which are detailed, emphasis is placed on the creation of an ion-depleted dark hole during the Bubble Machine II experiment; mechanisms explaining the phenomenon are outlined. The auroral intensity ion beams with energies of up to 6.8 keV, observed following the explosion in the field-aligned ion electrostatic analyzer, are suggested to represent an existing ion conic population pitch angle scattered by the released barium into the view of the detector.

  2. A scheme to produce high density and high temperature plasma for opacity measurement

    SciTech Connect

    Xu, Yan; Wu, SiZhong; Zheng, WuDi

    2015-04-15

    The opacity of shock-compressed material is of general scientific interest for astrophysical plasmas and for inertial confinement fusion research. A proposal is suggested to produce high temperature plasma with density around 1 g/cm{sup −3}. Two types of opacity target (the sandwich target and the foam enhanced sandwich target) are investigated numerically. The foam enhanced sandwich target has structure of foam–solid-sample-solid-foam. The foam will increase laser absorption efficiency and the ablating pressure. Hydrodynamic simulations confirm that the laser can be fully absorbed by the under-critical-density foam and a faster shock is produced inside the CH layer. High intensity lasers heat opacity target from both sides. The CH layers must be thick enough to keep the laser away from the sample. The laser-driven shocks move inward and collide at the center. Part of their kinetic energy is converted into internal energy and high density and high temperature local thermodynamic equilibrium sample plasma is produced. The plasma produced by laser heating the foam enhanced sandwich target has higher sample temperature than by laser heating the sandwich target. It may be useful for measuring the opacity of shock compressed material in laboratory.

  3. Cancer therapy using non-thermal atmospheric pressure plasma with ultra-high electron density

    SciTech Connect

    Tanaka, Hiromasa; Mizuno, Masaaki; Toyokuni, Shinya; Maruyama, Shoichi; Kodera, Yasuhiro; Terasaki, Hiroko; Adachi, Tetsuo; Kato, Masashi; Kikkawa, Fumitaka; Hori, Masaru

    2015-12-15

    Cancer therapy using non-thermal atmospheric pressure plasma is a big challenge in plasma medicine. Reactive species generated from plasma are key factors for treating cancer cells, and thus, non-thermal atmospheric pressure plasma with high electron density has been developed and applied for cancer treatment. Various cancer cell lines have been treated with plasma, and non-thermal atmospheric plasma clearly has anti-tumor effects. Recent innovative studies suggest that plasma can both directly and indirectly affect cells and tissues, and this observation has widened the range of applications. Thus, cancer therapy using non-thermal atmospheric pressure plasma is promising. Animal experiments and understanding the mode of action are essential for clinical application in the future. A new academic field that combines plasma science, the biology of free radicals, and systems biology will be established.

  4. Cancer therapy using non-thermal atmospheric pressure plasma with ultra-high electron density

    NASA Astrophysics Data System (ADS)

    Tanaka, Hiromasa; Mizuno, Masaaki; Toyokuni, Shinya; Maruyama, Shoichi; Kodera, Yasuhiro; Terasaki, Hiroko; Adachi, Tetsuo; Kato, Masashi; Kikkawa, Fumitaka; Hori, Masaru

    2015-12-01

    Cancer therapy using non-thermal atmospheric pressure plasma is a big challenge in plasma medicine. Reactive species generated from plasma are key factors for treating cancer cells, and thus, non-thermal atmospheric pressure plasma with high electron density has been developed and applied for cancer treatment. Various cancer cell lines have been treated with plasma, and non-thermal atmospheric plasma clearly has anti-tumor effects. Recent innovative studies suggest that plasma can both directly and indirectly affect cells and tissues, and this observation has widened the range of applications. Thus, cancer therapy using non-thermal atmospheric pressure plasma is promising. Animal experiments and understanding the mode of action are essential for clinical application in the future. A new academic field that combines plasma science, the biology of free radicals, and systems biology will be established.

  5. The impact of plasma triglyceride and apolipoproteins concentrations on high-density lipoprotein subclasses distribution

    PubMed Central

    2011-01-01

    Objective To investigate the effect of triglyceride (TG) integrates with plasma major components of apolipoproteins in HDL subclasses distribution and further elicited the TG-apolipoproteins (apos) interaction in the processes of high density lipoprotein (HDL) mature metabolic and atherosclerosis related diseases. Methods Contents of plasma HDL subclasses were quantities by two-dimensional gel electrophoresis associated with immunodetection in 500 Chinese subjects. Results Contents of preβ1-HDL, HDL3a, and apoB-100 level along with apoB-100/A-I ratio were significantly increased, whereas there was a significant reduction in the contents of HDL2, apoA-I level as well as apoC-III/C-II ratio with increased TG concentration. Moreover, preβ1-HDL contents is elevated about 9 mg/L and HDL2b contents can be reduced 21 mg/L for 0.5 mmol/L increment in TG concentration. Moreover, with increase of apoA-I levels, HDL2b contents were marginally elevated in any TG concentration group. Furthermore, despite of in the apoB-100/A-I < 0.9 group, the contents of preβ1-HDL increased, and those of HDL2b decreased significantly for subjects in both high and very high TG levels compared to that in normal TG levels. Similarly, in the apoB-100/A-I ≥ 0.9 group, the distribution of HDL subclasses also showed abnormality for subjects with normal TG levels. Conclusions The particle size of HDL subclasses tend to small with TG levels increased which indicated that HDL maturation might be impeded and efficiency of reverse cholesterol transport(RCT) might be weakened. These data suggest that TG levels were not only significantly associated with but liner with the contents of preβ1-HDL and HDL2b. They also raise the possibility that the TG levels effect on HDL maturation metabolism are subjected to plasma apolipoproteins and apolipoproteins ratios. PMID:21251287

  6. Fitzgerald factor (high molecular weight kininogen) clotting activity in human plasma in health and disease in various animal plasmas.

    PubMed

    Saito, H; Goldsmith, G; Waldmann, R

    1976-12-01

    Fitzgerald factor (high molecular weight kininogen) is an agent in normal human plasma that corrects the impaired in vitro surface-mediated plasma reactions of blood coagulation, fibrinolysis, and kinin generation observed in Fitzgerald trait plasma. To assess the possible pathophysiologic role of Fitzgerald factor, its titer was measured by a functional clot-promoting assay. Mean +/- SD in 42 normal adults was 0.99+/-0.25 units/ml, one unit being the activity in 1 ml of normal pooled plasma. No difference in titer was noted between normal men and women, during pregnancy, or after physical exercise. Fitzgerald factor activity was significantly reduced in the plasmas of eight patients with advanced hepatic cirrhosis (0.40+/-0.09 units/ml) and of ten patients with disseminated intravascular coagulation (0.60+/-0.30 units/ml), but was normal in plasmas of patients with other congenital clotting factor deficiencies, nephrotic syndrome, rheumatoid arthritis, systemic lupus erythematosus, or sarcoidosis, or under treatment with warfarin. The plasmas of 21 mammalian species tested appeared to contain Fitzgerald factor activity, but those of two avian, two repitilian, and one amphibian species did not correct the coagulant defect in Fitzgerald trait plasmas. PMID:1000085

  7. Generation of strongly coupled plasmas by high power excimer laser

    NASA Astrophysics Data System (ADS)

    Zhu, Yongxiang; Liu, Jingru; Zhang, Yongsheng; Hu, Yun; Zhang, Jiyan; Zheng, Zhijian; Ye, Xisheng

    2013-05-01

    (ultraviolet). To generate strongly coupled plasmas (SCP) by high power excimer laser, an Au-CH-Al-CH target is used to make the Al sample reach the state of SCP, in which the Au layer transforms laser energy to X-ray that heating the sample by volume and the CH layers provides necessary constraints. With aid of the MULTI-1D code, we calculate the state of the Al sample and its relationship with peak intensity, width and wavelength of laser pulses. The calculated results suggest that an excimer laser with peak intensity of the magnitude of 1013W/cm2 and pulse width being 5ns - 10ns is suitable to generate SCP with the temperature being tens of eV and the density of electron being of the order of 1022/cm-3. Lasers with shorter wavelength, such as KrF laser, are preferable.

  8. High resolution video monitoring of coating thickness during plasma spraying

    NASA Technical Reports Server (NTRS)

    Miller, Robert A.

    1988-01-01

    A new approach to monitoring the thickness of plasma sprayed coatings during application is described. The method employs a high resolution video camera and width analyzer to accurately measure the dimensions of samples having simple geometries. This approach is best suited for cylindrical or flat substrates but it may also work for selected locations on more complex geometries. Measurement accuracy is a function of specimen dimensions and extent of magnification. Tolerances of plus or minus 0.5 mil (0.13 mm) on final coating thickness can be achieved. Additionally, the plot of cumulative coating thickess versus the number of passes has proven to be a useful diagnostic tool. While the ideal plot is linear, strong deviations from linearity - indicating the need for corrective action - may be observed.

  9. Bubble Phenomena caused by High Repetitive Plasmas in Water

    NASA Astrophysics Data System (ADS)

    Akiyama, Masahiro; Oikawa, Takuma; Fue, Masatoshi; Ogata, Ryoma; Takaki, Koich; Akiyama, Hidenori; Iwate Univ Team; Kumamoto Univ Collaboration

    2015-09-01

    Streamer discharges in water were generated by a pulsed power generator. The streamer shape changed depending on pulse repetition rate. Streamer discharges at 500 pulses per second (pps) resulted in a ball shape. Under this formation, small bubbles gather near the electrode tip. Our aims are the analysis and discussion of the bubble phenomena caused by high repetitive plasmas produced in water. Pulsed power with a maximum output of 1 J/pulse was applied to an electrode of 0.8 mm in diameter covered by an insulator of 2 mm thickness. The electrode was inserted into tap water with conductivity of 170 uS/cm. The polarity was positive. Phenomena, in which the resulting gas bubbles oscillate and gather, were found to have an important role in producing ball shape streamer discharges.

  10. CENTER FOR PULSED POWER DRIVEN HIGH ENERGY DENSITY PLASMA STUDIES

    SciTech Connect

    Professor Bruce R. Kusse; Professor David A. Hammer

    2007-04-18

    This annual report summarizes the activities of the Cornell Center for Pulsed-Power-Driven High-Energy-Density Plasma Studies, for the 12-month period October 1, 2005-September 30, 2006. This period corresponds to the first year of the two-year extension (awarded in October, 2005) to the original 3-year NNSA/DOE Cooperative Agreement with Cornell, DE-FC03-02NA00057. As such, the period covered in this report also corresponds to the fourth year of the (now) 5-year term of the Cooperative Agreement. The participants, in addition to Cornell University, include Imperial College, London (IC), the University of Nevada, Reno (UNR), the University of Rochester (UR), the Weizmann Institute of Science (WSI), and the P.N. Lebedev Physical Institute (LPI), Moscow. A listing of all faculty, technical staff and students, both graduate and undergraduate, who participated in Center research activities during the year in question is given in Appendix A.

  11. High Power Light Gas Helicon Plasma Source for VASIMR

    NASA Technical Reports Server (NTRS)

    Squire, Jared P.; Chang-Diaz, Franklin R.; Glover, Timothy W.; Jacobson, Verlin T.; Baity, F. Wally; Carter, Mark D.; Goulding, Richard H.

    2004-01-01

    In the Advanced Space Propulsion Laboratory (ASPL) helicon experiment (VX-10) we have measured a plasma flux to input gas rate ratio near 100% for both helium and deuterium at power levels up to 10 kW. Recent results at Oak Ridge National Laboratory (ORNL) show enhanced efficiency operation with a high power density, over 5 kW in a 5 cm diameter tube. Our helicon is presently 9 cm in diameter and operates up to 10 kW of input power. The data here uses a Boswell double-saddle antenna design with a magnetic cusp just upstream of the antenna. Similar to ORNL, for deuterium at near 10 kW, we find an enhanced performance of operation at magnetic fields above the lower hybrid matching condition.

  12. On the atomic line profiles in high pressure plasmas

    SciTech Connect

    Janssen, J. F. J.; Gnybida, M.; Rijke, A. J.; Dijk, J. van; Suijker, J. L. G.

    2013-11-14

    In a previous contribution to this journal [H. P. Stormberg, J. Appl. Phys. 51(4), 1963 (1980)], Stormberg presented an analytical expression for the convolution of Lorentz and Levy line profiles, which models atomic radiative transitions in high pressure plasmas. Unfortunately, the derivations are flawed with errors and the final expression, while correct, is accompanied by misguiding comments about the meaning of the symbols used therein, in particular the “complex error function.” In this paper, we discuss the broadening mechanisms that give rise to Stormberg's model and present a correct derivation of his final result. We will also provide an alternative expression, based on the Faddeeva function, which has decisive computational advantages and emphasizes the real-valuedness of the result. The MATLAB/Octave scripts of our implementation have been made available on the publisher's website for future reference.

  13. On the atomic line profiles in high pressure plasmas

    NASA Astrophysics Data System (ADS)

    Janssen, J. F. J.; Gnybida, M.; Suijker, J. L. G.; Rijke, A. J.; van Dijk, J.

    2013-11-01

    In a previous contribution to this journal [H. P. Stormberg, J. Appl. Phys. 51(4), 1963 (1980)], Stormberg presented an analytical expression for the convolution of Lorentz and Levy line profiles, which models atomic radiative transitions in high pressure plasmas. Unfortunately, the derivations are flawed with errors and the final expression, while correct, is accompanied by misguiding comments about the meaning of the symbols used therein, in particular the "complex error function." In this paper, we discuss the broadening mechanisms that give rise to Stormberg's model and present a correct derivation of his final result. We will also provide an alternative expression, based on the Faddeeva function, which has decisive computational advantages and emphasizes the real-valuedness of the result. The MATLAB/Octave scripts of our implementation have been made available on the publisher's website for future reference.

  14. Palpable pediatric thyroid abnormalities – diagnostic pitfalls necessitate a high index of clinical suspicion: a case report

    PubMed Central

    Klopper, Joshua P; McDermott, Michael T

    2007-01-01

    A 12-year-old girl presented with a 4 year history of an enlarged, firm thyroid gland. On exam, her thyroid was firm and fixed and an enlarged cervical lymph node was palpable as well. Though a thyroid ultrasound prior to referral was read as thyroiditis, clinical suspicion for thyroid carcinoma mandated continued investigation. The diagnosis of papillary thyroid cancer was established and her workup revealed lymph node metastases as well as a tremendous burden of pulmonary metastases. Pediatric thyroid cancer is extremely rare, but often presents with aggressive disease. Palpable thyroid abnormalities in an individual under 20-years-old should be viewed with suspicion and should be thoroughly investigated to rule out malignancy even in the face of negative diagnostic procedures. Though pediatric papillary thyroid cancer often presents with loco-regional and even distant metastatic disease, mortality rates in follow-up for as long as 20 years are very favorable. PMID:17587454

  15. Plasma density increase in the high altitude polar cap

    NASA Astrophysics Data System (ADS)

    Kitanoya, Yugo; Abe, Takumi; Mukai, Toshifumi

    In general situation, the electron density in the ionosphere decreases with altitude. As for the latitudinal variation, the electron density is generally smaller in the polar cap than in the midor low-latitude region. Few reliable measurements have been made to estimate thermal electron density and temperature with a simple instrument such as Langmuir probe in the highaltitude polar cap region. For example, only the limited amount of the electron temperature and density data are available for the high-altitude (> 3000 km) polar cap, where the density is generally less than 2.0*103 [/cm3 ]. Since the plasma density significantly correlates with the solar activity, thermal plasma density becomes smaller for the minimum solar activity period. Thermal Electron energy Distribution (TED) instrument onboard "AKEBONO" (EXOS-D) satellite has been operated in two modes; 1) DC mode to obtain the probe characteristic, 2) SH (second harmonic) mode to estimate the electron energy distribution function based on Druyvesteyn method, from which the electron temperature and density can be estimated even on the condition of low electron density. On the basis of statistical study of the Akebono observation for over 10 years, it is found that the electron number density occasionally increases up to 3.0-4.0*103 [/cm3 ] above altitude of 3000 km. While the electron temperature is believed to be about 8000 K at such a high altitude, the temperature inside the high density region is observed to be lower than that by several thousand degrees. It is noticeable that such a density enhancement occurs during the geomagnetically active period at solar maximum. The high density region is observed to exist not in whole but in part of the polar cap. In addition, it is obvious from the Suprathermal Mass Spectrometer (SMS) observations that the H+ velocity parallel to the upward field aligned direction is observed to be lower in the high density region than the surrounding region. Also, it is

  16. [An acute severe heat stroke patient showing abnormal diffuse high intensity of the cerebellar cortex in diffusion weighted image: a case report].

    PubMed

    Fujioka, Yusuke; Yasui, Keizo; Hasegawa, Yasuhiro; Takahashi, Akira; Sobue, Gen

    2009-10-01

    A 47-year-old man was admitted to the hospital because of general convulsion, loss of consciousness and hyperthermia. A diagnosis of acute heat stroke was made clinically and neuroradiologically. As the consciousness level ameliorated, he developed severe abulia and mutism, then cerebellar ataxic syndrome (viz. truncal ataxia, hypermetria, ataxic speech and nystagmus). An MRI (diffusion weighted image; DWI) disclosed abnormal diffuse high signal intensity of the cerebellar cortex with reduced apparent diffusion coefficient (ADC). Two months later after the onset, truncal ataxia and dysarthria significantly improved, while dysmetria of the extremities rather worsened. At that time, the abnormal signal intensity of the cerebellar cortex disappeared, and the cerebellum became atrophic. The cerebellar blood flow was significantly decreased on brain SPECT (99mTc-ECD). The abnormal DWI signal intensity of the cerebellar cortex in the present patient may represent the cytotoxic edema of Purkinje cells resulting from heat stroke-related hyperthermia It is essential to repeat MRI examination for cerebellar pathology and to obtain better insight into sequelae in patients with acute heat stroke. Protirelin tartrate seemed to be valid for improvement of abulia in the present patient. Further study is indicated. PMID:19999144

  17. Quantification of the DNA content of structurally abnormal X chromosomes and X chromosome aneuploidy using high resolution bivariate flow karyotyping.

    PubMed

    Trask, B; van den Engh, G; Nussbaum, R; Schwartz, C; Gray, J

    1990-01-01

    Quantification of the Hoechst and chromomycin A3 fluorescence intensities of mitotic human chromosomes isolated from karyotypically normal and abnormal cells was performed with a dual beam flow cytometer. The resultant flow karyotypes contain information about the relative DNA content and base composition of chromosomes and their relative frequencies in the mitotic cell sample. The relative copy number of X and Y chromosomes was determined for 38 normal males and females and 6 cell lines with X or Y chromosome aneuploidy. Flow karyotype diagnoses corresponded with conventional cytogenetic results in all cases. We show that chromosome DNA content can be derived from peak position in Hoechst vs. chromomycin flow karyotypes. These values are linearly related to propidium iodide staining intensity as measured with flow cytometry and to the binding of gallocyanin chrome alum to phosphate groups as measured with slide-based scanning photometry. Cell lines with deleted or dicentric X chromosomes ranging in length from 0.53 to 1.95 times normal were analyzed by using flow cytometry. The measured difference in DNA content between a normal X and each of the structurally abnormal chromosomes was linearly correlated to the difference predicted from cytogenetics and/or probe analyses. Deletions of 3-5 Mb, which were at and below the detection limits of conventional cytogenetics, could be quantified by flow karyotyping in individuals with X-linked diseases such as Duchenne muscular dystrophy, choroideremia, and ocular albinism/ichthyosis. The results show that the use of flow karyotyping to quantify the size of restricted regions of the genome can complement conventional cytogenetics and other physical mapping techniques in the study of genetic disorders. PMID:2106419

  18. Ion drag force on a small grain in highly collisional weakly anisotropic plasma: Effect of plasma production and loss mechanisms

    SciTech Connect

    Chaudhuri, M.; Khrapak, S. A.; Morfill, G. E.

    2008-05-15

    The ion drag force acting on a small absorbing grain has been calculated in highly collisional plasma with slowly drifting ions taking into account plasma production and loss processes in the vicinity of the grain. It is shown that the strength of the plasma production and loss mechanisms not only affects the magnitude of the ion drag force, but also determines the direction of the force. The parameter regimes for the ''positive'' and ''negative'' ion drag forces have been identified. In addition, the qualitative features of the electric potential distribution around the grain in isotropic conditions (in the absence of the ion drift) are investigated.

  19. Abnormal Changes of Brain Cortical Anatomy and the Association with Plasma MicroRNA107 Level in Amnestic Mild Cognitive Impairment

    PubMed Central

    Wang, Tao; Shi, Feng; Jin, Yan; Jiang, Weixiong; Shen, Dinggang; Xiao, Shifu

    2016-01-01

    MicroRNA107 (Mir107) has been thought to relate to the brain structure phenotype of Alzheimer’s disease. In this study, we evaluated the cortical anatomy in amnestic mild cognitive impairment (aMCI) and the relation between cortical anatomy and plasma levels of Mir107 and beta-site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1). Twenty aMCI (20 aMCI) and 24 cognitively normal control (NC) subjects were recruited, and T1-weighted MR images were acquired. Cortical anatomical measurements, including cortical thickness (CT), surface area (SA), and local gyrification index (LGI), were assessed. Quantitative RT-PCR was used to examine plasma expression of Mir107, BACE1 mRNA. Thinner cortex was found in aMCI in areas associated with episodic memory and language, but with thicker cortex in other areas. SA decreased in aMCI in the areas associated with working memory and emotion. LGI showed a significant reduction in aMCI in the areas involved in language function. Changes in Mir107 and BACE1 messenger RNA plasma expression were correlated with changes in CT and SA. We found alterations in key left brain regions associated with memory, language, and emotion in aMCI that were significantly correlated with plasma expression of Mir107 and BACE1 mRNA. This combination study of brain anatomical alterations and gene information may shed lights on our understanding of the pathology of AD. Clinical Trial Registration: http://www.ClinicalTrials.gov, identifier NCT01819545. PMID:27242521

  20. High βp plasma formation using off-axis ECCD in Ohmic heated plasma in the spherical tokamak QUEST

    NASA Astrophysics Data System (ADS)

    Mishra, Kishore; Zushi, H.; Idei, H.; Hasegawa, M.; Hanada, K.

    2015-03-01

    High poloidal beta (ɛβp ~ 1) operation in steady state condition in tokamaks is of great interest and has previously been demonstrated using NBI, LHCD and low current (Ip) plasma for a short time (<0.5 s). A very few experiments however, have been performed towards the investigation of highest obtainable βp in tokamak plasma. In this work we report the first result of high βp production and its sustainment though an off axis ECCD at two different frequencies (fundamental and second harmonic) in Ohmic (OH) target plasma. With application of ECCD, plasma βp increased to encounter an equilibrium limit and the standard limiter configuration is transformed to an Inboard Poloidal field Null (IPN) configuration. Both off-axis and on-axis ECCD is studied and found to have some distinctive features, which are discussed in this paper.

  1. Diamagnetic Effect in a Partially-Ionized High-Beta Plasma

    NASA Astrophysics Data System (ADS)

    Fruchtman, Amnon; Shinohara, Shunjiro

    2015-11-01

    Balance between magnetic pressure and plasma pressure is expected in fully ionized plasmas confined by a magnetic field. The magnetic force on the plasma is due to a current carried by the plasma which is diamagnetic. The magnetic field inside the plasma is then lowered by that current. In a partially-ionized plasma, however, the plasma pressure is balanced not only by the magnetic field pressure but also by neural-gas pressure. In that case the diamagnetic effect of the plasma, even if high beta, is expected to be lower. We calculate the steady-state of a cylindrical low temperature magnetized partially-ionized plasma (such as rf plasma source). We solve for the radial dependencies of the plasma density, the neutral density, and the magnetic field profile. Neutral pressure gradient is established by neutral depletion under the plasma pressure. We demonstrate how neutral depletion affects the diamagnetic effect of a high beta plasma. This work was partially supported by JSPS, Japan, and by ISF, Israel.

  2. Plasma puff initiation of high Coulomb transfer switches

    NASA Technical Reports Server (NTRS)

    Venable, D. D.; Choi, E. H.

    1990-01-01

    The plasma-puff triggering mechanism based on a hypocycloidal pinch geometry was investigated to determine the optimal operating conditions for the azimuthally uniform surface flashover which initiates plasma-puff under wide range of fill gas pressure of Ar, He and N2. The optimal fill gas pressure for the azimuthally uniform plasma-puff was about 120 mTorr and 450 Torr for He and N2, and between 120 mTorr and 5 Torr for Ar. The inverse pinch switch was triggered with the plasma-puff and the switching capability under various electrical parameters and working gas pressures of Ar, He and N2 was determined. It was also shown that the azimuthally uniform switching discharges were dependent on the type of fill gas and its fill pressure. A new concept of plasma-focus driven plasma-puff was also discussed in comparison with the hypocycloidal pinch plasma-puff triggering. The main discharge of inverse pinch switch with plasma-focus driven plasma-puff trigger is found to be more azimuthally uniform than that with hypocycloidal pinch plasma-puff trigger in a gas pressure region between 80 mTorr and 1 Torr.

  3. Simulations of a High-Transformer-Ratio Plasma Wakefield Accelerator Using Multiple Electron Bunches

    SciTech Connect

    Kallos, Efthymios; Muggli, Patric; Katsouleas, Thomas; Yakimenko, Vitaly; Park, Jangho

    2009-01-22

    Particle-in-cell simulations of a plasma wakefield accelerator in the linear regime are presented, consisting of four electron bunches that are fed into a high-density plasma. It is found that a high transformer ratio can be maintained over 43 cm of plasma if the charge in each bunch is increased linearly, the bunches are placed 1.5 plasma wavelengths apart and the bunch emmitances are adjusted to compensate for the nonlinear focusing forces. The generated wakefield is sampled by a test witness bunch whose energy gain after the plasma is six times the energy loss of the drive bunches.

  4. Blistering on tungsten surface exposed to high flux deuterium plasma

    NASA Astrophysics Data System (ADS)

    Xu, H. Y.; Liu, W.; Luo, G. N.; Yuan, Y.; Jia, Y. Z.; Fu, B. Q.; De Temmerman, G.

    2016-04-01

    The blistering behaviour of tungsten surfaces exposed to very high fluxes (1-2 × 1024/m2/s) of low energy (38 eV) deuterium plasmas was investigated as a function of ion fluence (0.2-7 × 1026 D/m2) and surface temperature (423-873 K). Blisters were observed under all conditions, especially up to temperatures of 873 K. The blister parameters are evaluated with blister size, blister density and surface coverage. The blister size always peaked at less than 0.5 μm and no blister larger than 10 μm is observed even at high fluence. The blister densities are found in high magnitude of 106 blisters/m2, with the surface coverages lower than 2%. The formation of cracks in the sub-surface region was observed by cross-section imaging. Changes in blister size and shape with fluence and temperature suggest processes of predominantly nucleation and subsequent growth of blisters. The smaller blister size is considered to be caused by a combination of flux-related effects such as enhanced defect formation in the near surface region, reduced deuterium diffusivity and relatively short exposure times.

  5. Entrainment in High-Velocity, High Temperature Plasma Jets Part I: Experimental Results

    SciTech Connect

    Fincke, J.R.; Crawford, D.M.; Snyder, S.C.; Swank, W.D.; Haggard, D.C.; Williamson, R.L.

    2002-03-27

    The development of a high-velocity, high-temperature argon plasma jet issuing into air has been investigated. In particular the entrainment of the surrounding air, its effect on the temperature and velocity profiles and the subsequent mixing and dissociation of oxygen has been examined in detail. The total concentration of oxygen and the velocity and temperature profiles in the jet were obtained from an enthalpy probe. High-resolution Thomson scattering provided an independent measure of plasma velocity and temperature, validating enthalpy probe measurements and providing non-intrusive measurements near the nozzle exit. The concentration of atomic oxygen was obtained from two-photon Laser Induced Fluorescence (LIF). Molecular oxygen concentration and temperature was obtained from Coherent Anti-Stokes Raman Spectroscopy (CARS). It was found that both the incompleteness of mixing at the molecular scale and the rate of oxygen dissociation and recombination effects jet behavior.

  6. Surface morphology and deuterium retention in tungsten exposed to high flux D plasma at high temperatures

    NASA Astrophysics Data System (ADS)

    Jia, Y. Z.; De Temmerman, G.; Luo, G.-N.; Xu, H. Y.; Li, C.; Fu, B. Q.; Liu, W.

    2015-02-01

    Surface modifications and deuterium retention induced in tungsten by high fluxes (1024 m-2 s-1) low energy (38 eV) deuterium ions were studied as a function of surface temperature. Blister formation was studied by scanning electron microscopy and electron backscatter diffraction, while deuterium retention was measured by thermal desorption spectroscopy. Blisters are observed on the surface exposed at different temperatures, ranging from 493 K to 1273 K. The blister density and D retention decrease with the increasing exposure temperature. The formation of blisters at high temperatures is attributed to the high flux of D plasma. At 943 K, with the increasing fluence, there is trend to the saturation of D retention and blister density. The defects caused by plasma exposure have an important effect on the D trapping and blistering behavior. The formation of blisters has a strong relationship with slipping system of tungsten.

  7. Low-pressure, high-density, and supersonic plasma flow generated by a helicon magnetoplasmadynamic thruster

    NASA Astrophysics Data System (ADS)

    Takahashi, Kazunori; Komuro, Atsushi; Ando, Akira

    2014-11-01

    A high density magnetoplasmadynamic (MPD) plasma under a magnetic nozzle is produced with a low gas flow rate of argon by combining helicon and MPD plasma sources, where a cathode and an anode are located upstream and downstream of the helicon source, respectively. Once the high density helicon plasma is produced in the source tube, a pulsed current of a few kA is triggered between the cathode and anode. A plasma density above 1020 m-3 and a supersonic plasma flow (Mach number of ˜1.8) are obtained at ˜10 cm downstream of the source exit. As the thrust efficiency estimated from the measured plasma parameters is much higher than that of the simple MPD thruster, the helicon MPD thruster being proposed and tested potentially provides more efficient high-power plasma thruster.

  8. Plasma and electric field boundaries at high and low altitudes on July 29, 1977

    NASA Technical Reports Server (NTRS)

    Fennell, J. F.; Johnson, R. G.; Young, D. T.; Torbert, R. B.; Moore, T. E.

    1982-01-01

    Hot plasma observations at high and low altitudes were compared. The plasma ion composition at high altitudes outside the plasmasphere was 0+. Heavy ions were also observed at low altitudes outside the plasmasphere. It is shown that at times these ions are found well below the plasmapause inside the plasmasphere. Comparisons of the low altitude plasma and dc electric fields show that the outer limits of the plasmasphere is not always corotating at the low L-shells. The corotation boundary, the estimated plasmapause boundary at the boundary of the inner edge of plasma sheet ions were at the same position. The inner edge of plasma sheet electrons is observed at higher latitudes than the plasmasphere boundary during disturbed times. The inner edge of the plasma sheaths shows a strong dawn to dusk asymmetry. At the same time the inner edge of the ring current and plasma sheath also moves to high latitudes reflecting an apparent inflation of the magnetosphere.

  9. High Power Dynamic Polarization Control Using Plasma Photonics

    NASA Astrophysics Data System (ADS)

    Turnbull, D.; Michel, P.; Chapman, T.; Tubman, E.; Pollock, B. B.; Chen, C. Y.; Goyon, C.; Ross, J. S.; Divol, L.; Woolsey, N.; Moody, J. D.

    2016-05-01

    We report the first experimental demonstration of a plasma wave plate based on laser-induced birefringence. An elliptically polarized input was converted into a nearly ideal circularly polarized beam using an optical system composed of a second laser beam and a plasma. The results are in excellent agreement with linear theory and three-dimensional simulations up to phase delays exceeding π /4 , thus establishing the feasibility of laser-plasma photonic devices that are ultrafast, damage-resistant, and easily tunable.

  10. Coaxial plasma thrusters for high specific impulse propulsion

    NASA Technical Reports Server (NTRS)

    Schoenberg, Kurt F.; Gerwin, Richard A.; Barnes, Cris W.; Henins, Ivars; Mayo, Robert; Moses, Ronald, Jr.; Scarberry, Richard; Wurden, Glen

    1991-01-01

    A fundamental basis for coaxial plasma thruster performance is presented and the steady-state, ideal MHD properties of a coaxial thruster using an annular magnetic nozzle are discussed. Formulas for power usage, thrust, mass flow rate, and specific impulse are acquired and employed to assess thruster performance. The performance estimates are compared with the observed properties of an unoptimized coaxial plasma gun. These comparisons support the hypothesis that ideal MHD has an important role in coaxial plasma thruster dynamics.

  11. A study of the abnormal lipoproteins in abetalipoproteinemia.

    PubMed Central

    Scanu, A M; Aggerbeck, L P; Kruski, A W; Lim, C T; Kayden, H J

    1974-01-01

    The serum lipoproteins of five patients with abetalipoproteinemia (ABL) were separated by ultracentrifugation and then analyzed either intact or after delipidation. In accord with previous findings, all of the patients lacked serum particles with the characteristics of normal low-density lipoproteins (LDL) and of the LDL apoprotein as assessed by immunochemical methods. Each patient exhibited on every examination an abnormal particle, "LDL", which had the flotational properties of LDL, the polypeptide makeup of high-density lipoproteins HDL, the spectral and morphological characteristics of neither LDL nor HDL, and a relatively low content of cholesteryl esters. The HDL were abnormal in having a marked decrease in their total plasma content, an altered proportion of the subclasses HDL2 and HDL3, and a peculiar polypeptide distribution, comprising both normal and additional components, usually not seen in normal controls. The patients also exhibited a decrease of plasma lecithin-cholesterol acyl transferase (LCAT) activity which probably accounted for the low content of cholesteryl esters in both "LDL" and HDL, and in turn for the unusual appearance of "LDL" on electron microscopy. It is concluded that ABL is a disorder affecting all serum lipoprotein classes. Whether the abetalipoproteinemia previously described and noted in the current studies is related to or independent of the abnormalities observed in the other lipoproteins was not established. How the deficiency of LCAT activity, observed in all patients studied, contributed to some of the observed structural lipoprotein abnormalities also remained undetermined. Images PMID:11344558

  12. Characterization of Wet Air Plasma Jet Powered by Sinusoidal High Voltage and Nanosecond Pulses for Plasma Agricultural Application

    NASA Astrophysics Data System (ADS)

    Takashima, Keisuke; Shimada, Keisuke; Konishi, Hideaki; Kaneko, Toshiro

    2015-09-01

    Not only for the plasma sterilization but also for many of plasma life-science applications, atmospheric pressure plasma devices that allowed us to control its state and reactive species production are deserved to resolve the roles of the chemical species. Influence of the hydroxyl radical and ozone on germination of conidia of a strawberry pathogen is presented. Water addition to air plasma jet significantly improves germination suppression performance, while measured reactive oxygen species (ROS) are reduced. Although the results show a negative correlation between ROS and the germination suppression, this infers the importance of chemical composition generated by plasma. For further control of the plasma product, a plasma jet powered by sinusoidal high voltage and nanosecond pulses is developed and characterized with the voltage-charge Lissajous. Control of breakdown phase and discharge power by pulse-imposed phase is presented. This work is supported by JSPS KAKENHI Grant-in-Aid for Young Scientists (B) Grant Number 15K17480 and Exploratory Research Grant Number 23644199.

  13. Formation of high-{beta} plasma and stable confinement of toroidal electron plasma in Ring Trap 1

    SciTech Connect

    Saitoh, H.; Yoshida, Z.; Morikawa, J.; Furukawa, M.; Yano, Y.; Kawai, Y.; Kobayashi, M.; Vogel, G.; Mikami, H.

    2011-05-15

    Formation of high-{beta} electron cyclotron resonance heating plasma and stable confinement of pure electron plasma have been realized in the Ring Trap 1 device, a magnetospheric configuration generated by a levitated dipole field magnet. The effects of coil levitation resulted in drastic improvements of the confinement properties, and the maximum local {beta} value has exceeded 70%. Hot electrons are major component of electron populations, and its particle confinement time is 0.5 s. Plasma has a peaked density profile in strong field region [H. Saitoh et al., 23rd IAEA Fusion Energy Conference EXC/9-4Rb (2010)]. In pure electron plasma experiment, inward particle diffusion is realized, and electrons are stably trapped for more than 300 s. When the plasma is in turbulent state during beam injection, plasma flow has a shear, which activates the diocotron (Kelvin-Helmholtz) instability. The canonical angular momentum of the particle is not conserved in this phase, realizing the radial diffusion of charged particles across closed magnetic surfaces. [Z. Yoshida et al., Phys Rev. Lett. 104, 235004 (2010); H. Saitoh et al., Phys. Plasmas 17, 112111 (2010).].

  14. Compact High-Velocity Atmospheric Pressure Dielectric Barrier Plasma Jet in Ambient Air

    NASA Astrophysics Data System (ADS)

    Annette, Meiners; Michael, Leck; Bernd, Abel

    2015-01-01

    In this paper, a non-thermal atmospheric pressure plasma jet at high streaming velocity operating with ambient air is highlighted. In the present technological approach, the employment of air poses a significant challenge. The high oxygen concentration in air results in a reduced concentration of reactive species in combination with a short species lifetime. The plasma jet assembly presented here contains a special dielectric barrier with a high secondary emission coefficient. In this way, the electron density and in turn the density of reactive species is increased. In addition, the plasma jet assembly is equipped with a short electrode. This leads to a higher voltage across the discharge gap and in turn to an increased density of reactive plasma species. The plasma jet is formed within and emitted by a small conical nozzle. A high-speed gas flow with gas velocity of 340 m/s was achieved at the end of the nozzle. In the jet the concentration of toxic and unwanted neutral plasma species like O3 or NOx is significantly reduced because of the shorter residence time within the plasma. The range of short-lived active plasma species is in turn considerably enhanced. The jet efficiency and action range measured through the oxidation of a test surface were determined by measuring the increase of surface tension of a polypropylene substrate via contact angle measurements after plasma treatment. Numerical modeling of the plasma plume indicates that oxygen atoms are in fact the main active species in the plasma plume.

  15. Initial simulation of MHD instabilites in a high speed plasma accelerator

    NASA Astrophysics Data System (ADS)

    Kim, Jin-Soo; Hughes, Tom; Thio, Francis

    2005-10-01

    High density, high Mach number plasma jets are under development for a variety of critical fusion applications. These applications include fueling, rotation driving, and disruption mitigation in magnetic fusion devices. They also include a range of innovative approaches to high energy density plasmas. FAR-TECH, Inc. has begun 3D MHD simulations using the LSP code [1] to examine such high speed plasma jets. An initial study to benchmark the code is currently underway. The blow-by instability will be simulated in a coaxial plasma accelerator using the 3D LSP code and compared with the 2D MACH2 code results. [1] LSP-Manual-MRC-ABQ-R-1942.pdf

  16. High-density plasma deposition manufacturing productivity improvement

    NASA Astrophysics Data System (ADS)

    Olmer, Leonard J.; Hudson, Chris P.

    1999-09-01

    High Density Plasma (HDP) deposition provides a means to deposit high quality dielectrics meeting submicron gap fill requirements. But, compared to traditional PECVD processing, HDP is relatively expensive due to the higher capital cost of the equipment. In order to keep processing costs low, it became necessary to maximize the wafer throughput of HDP processing without degrading the film properties. The approach taken was to optimize the post deposition microwave in-situ clean efficiency. A regression model, based on actual data, indicated that number of wafers processed before a chamber clean was the dominant factor. Furthermore, a design change in the ceramic hardware, surrounding the electrostatic chuck, provided thermal isolation resulting in an enhanced clean rate of the chamber process kit. An infra-red detector located in the chamber exhaust line provided a means to endpoint the clean and in-film particle data confirmed the infra-red results. The combination of increased chamber clean frequency, optimized clean time and improved process.

  17. THE TURBULENT DYNAMO IN HIGHLY COMPRESSIBLE SUPERSONIC PLASMAS

    SciTech Connect

    Federrath, Christoph; Schober, Jennifer; Bovino, Stefano; Schleicher, Dominik R. G.

    2014-12-20

    The turbulent dynamo may explain the origin of cosmic magnetism. While the exponential amplification of magnetic fields has been studied for incompressible gases, little is known about dynamo action in highly compressible, supersonic plasmas, such as the interstellar medium of galaxies and the early universe. Here we perform the first quantitative comparison of theoretical models of the dynamo growth rate and saturation level with three-dimensional magnetohydrodynamical simulations of supersonic turbulence with grid resolutions of up to 1024{sup 3} cells. We obtain numerical convergence and find that dynamo action occurs for both low and high magnetic Prandtl numbers Pm = ν/η = 0.1-10 (the ratio of viscous to magnetic dissipation), which had so far only been seen for Pm ≥ 1 in supersonic turbulence. We measure the critical magnetic Reynolds number, Rm{sub crit}=129{sub −31}{sup +43}, showing that the compressible dynamo is almost as efficient as in incompressible gas. Considering the physical conditions of the present and early universe, we conclude that magnetic fields need to be taken into account during structure formation from the early to the present cosmic ages, because they suppress gas fragmentation and drive powerful jets and outflows, both greatly affecting the initial mass function of stars.

  18. Interaction of high voltage surfaces with the space plasma

    NASA Technical Reports Server (NTRS)

    Kaufman, H. R.; Robinson, R. S.

    1980-01-01

    High voltage solar arrays provide spacecraft power while optimizing mass and power efficiency. Operating such arrays in the space plasma environment can result in anomalously large currents being collected through insulation defects. Two thicknesses of the insulating material were tested, with no effect found due to insulator thickness. In these tests the polyimide thickness was always much less than the pinhole diameter. The pinhole area was varied over an area range of more than 30:1. It was found that the current collected was independent of the pinhole area for hole diameters from 0.35 to 2.0 mm. Two types of adhesives were tried in two different configurations. The adhesives were chosen for their extreme difference in vacuum qualifications. Neither adhesive types nor configuration made a significant difference in current collection. The temperature of the insulating material was also varied. It was found that current collection decreased with increasing temperature. Tests were conducted to see if pinhole current collection decreased with time, as was indicated by the effects of several short tests. Current was collected for over four hours while the conductor potential was held constant at 1000 volts. A smooth decrease with time was not observed, but rather a roughly constant current collection with brief surges to high values. Tests were also conducted with the simulated solar cell biased negative. The current was found to be proportional to pinhole area.

  19. Ulysses solar wind plasma observations at high latitudes

    SciTech Connect

    Riley, P.; Bame, S.J.; Barraclough, B.L.

    1996-10-01

    Ulysses reached its peak northerly heliolatitude of 80.2{degrees}N on July 31, 1995, and now is moving towards aphelion at 5.41 AU which it will reach in May, 1998. We summarize measurements from the solar wind plasma experiment, SWOOPS, emphasizing northern hemispheric observations but also providing southern and equatorial results for comparison. The solar wind momentum flux during Ulysses` fast pole-to- pole transit at solar minimum was significantly higher over the poles than at near-equatorial latitudes, suggesting a non-circular cross section for the heliosphere. Furthermore, modest asymmetries in the wind speed, density, and mass flux were observed between the two hemispheres during the fast latitude scan. The solar wind was faster and less dense in the north than in the south. These asymmetries persist in the most recent high- and mid-latitude data but are less pronounced. As of July 1, 1996 the northern fast solar wind has lacked any strong stream interactions or shocks and, although a comprehensive search has not yet been made, no CMEs have yet been identified during this interval. On the other hand, Alfv{acute e}nic, compressional, and pressure balanced features are abundant at high latitudes. The most recent data, at 4 AU and 32{degrees}N, has begun to show the effects of solar rotation modulated features in the form of recurrent compressed regions.

  20. Self-consistent electrodynamics of large-area high-frequency capacitive plasma discharge

    SciTech Connect

    Chen Zhigang; Rauf, Shahid; Collins, Ken

    2010-10-15

    Capacitively coupled plasmas (CCPs) generated using high frequency (3-30 MHz) and very high frequency (30-300 MHz) radio-frequency (rf) sources are used for many plasma processing applications including thin film etching and deposition. When chamber dimensions become commensurate with the effective rf wavelength in the plasma, electromagnetic wave effects impose a significant influence on plasma behavior. Because the effective rf wavelength in plasma depends upon both rf and plasma process conditions (e.g., rf power and gas pressure), a self-consistent model including both the rf power delivery system and the plasma discharge is highly desirable to capture a more complete physical picture of the plasma behavior. A three-dimensional model for self-consistently studying both electrodynamic and plasma dynamic behavior of large-area (Gen 10, >8 m{sup 2}) CCP is described in this paper. This model includes Maxwell's equations and transport equations for charged and neutral species, which are coupled and solved in the time domain. The complete rf plasma discharge chamber including the rf power delivery subsystem, rf feed, electrodes, and the plasma domain is modeled as an integrated system. Based on this full-wave solution model, important limitations for processing uniformity imposed by electromagnetic wave propagation effects in a large-area CCP (3.05x2.85 m{sup 2} electrode size) are studied. The behavior of H{sub 2} plasmas in such a reactor is examined from 13.56 to 200 MHz. It is shown that various rectangular harmonics of electromagnetic fields can be excited in a large-area rectangular reactor as the rf or power is increased. The rectangular harmonics can create not only center-high plasma distribution but also high plasma density at the corners and along the edges of the reactor.

  1. Spectroscopic Measurement of High-Frequency Electric Fields in the Interaction of Explosive Debris Plasma with Ambient, Magnetized Background Plasma

    NASA Astrophysics Data System (ADS)

    Bondarenko, Anton; Schaeffer, Derek; Everson, Erik; Clark, Eric; Vincena, Stephen; van Compernolle, Bart; Tripathi, Shreekrishna; Constantin, Carmen; Niemann, Chris

    2014-10-01

    The explosive expansion of dense, high-beta debris plasma into relatively tenuous, magnetized background plasma is relevant to a wide variety of astrophysical and space environments. Electric fields play a fundamental role in the coupling of momentum and energy from debris to background, and emission spectroscopy provides a powerful diagnostic for assessing electric fields via the Stark effect. A recent experiment utilizing a unique experimental platform at UCLA that combines the Large Plasma Device and the Raptor laser facility has investigated the super-Alfvénic, quasi-perpendicular expansion of a laser-produced carbon (C) debris plasma through a preformed, ambient, magnetized helium (He) background plasma via emission spectroscopy. Spectral profiles of the He II 468.6 nm line have been analyzed via single-mode and multi-mode time-dependent Stark broadening models for hydrogen-like ions, yielding large magnitude (~100 kV/cm), high-frequency (~100 GHz) electric fields. The measurements suggest the development of an electron beam-plasma instability, and a simple instability saturation model demonstrates that the measured electric field magnitudes are feasible under the experimental conditions.

  2. A plasma generator utilizing the high intensity ASTROMAG magnets

    NASA Technical Reports Server (NTRS)

    Sullivan, James D.; Post, R. S.; Lane, B. G.; Tarrh, J. M.

    1986-01-01

    The magnet configuration for the proposed particle astrophysics magnet facility (ASTROMAG) on the space station includes a cusp magnetic field with an intensity of a few tesla. With these large magnets (or others) located in the outer ionosphere, many quite interesting and unique plasma physics experiments become possible. First there are studies utilizing the magnet alone to examine the supersonic, sub-Alfvenic interaction with the ambient medium; the scale length for the magnet perturbation is approx. 20 m. The magnetic field geometry when combined with the Earth's and their relative motion will give rise to a host of plasma phenomena: ring nulls, x-points, ion-acoustic and lower-hybrid shocks, electron heating (possible shuttle glow without a surface) launching of Alfvenwaves, etc. Second, active experiments are possible for a controlled study of fundamental plasma phenomena. A controlled variable species plasma can be made by using an RF ion source; use of two soft iron rings placed about the line cusp would give an adequate resonance zone (ECH or ICH) and a confining volume suitable for gas efficiency. The emanating plasma can be used to study free expansion of plasma along and across field lines (polar wind), plasma flows around the space platform, turbulent mixing in the wake region, long wavelength spectrum of convecting modes, plasma-dust interactions, etc.

  3. US-Japan workshop Q-181 on high heat flux components and plasma-surface interactions for next devices: Proceedings

    SciTech Connect

    McGrath, R.T.; Yamashina, T.

    1994-04-01

    This report contain viewgraphs of papers from the following sessions: plasma facing components issues for future machines; recent PMI results from several tokamaks; high heat flux technology; plasma facing components design and applications; plasma facing component materials and irradiation damage; boundary layer plasma; plasma disruptions; conditioning and tritium; and erosion/redeposition.

  4. Abnormal Head Position

    MedlinePlus

    ... cause. Can a longstanding head turn lead to any permanent problems? Yes, a significant abnormal head posture could cause permanent ... occipitocervical synostosis and unilateral hearing loss. Are there any ... postures? Yes. Abnormal head postures can usually be improved depending ...

  5. Urine - abnormal color

    MedlinePlus

    ... straw-yellow. Abnormally colored urine may be cloudy, dark, or blood-colored. Causes Abnormal urine color may ... red blood cells, or mucus in the urine. Dark brown but clear urine is a sign of ...

  6. High-performance liquid chromatographic assay for the quantitation of L-arginine in human plasma.

    PubMed

    Gopalakrishnan, V; Burton, P J; Blaschke, T F

    1996-10-01

    L-Arginine is metabolized to nitric oxide by nitric oxide synthase, and abnormalities in nitric oxide production have been implicated in the pathogenesis of some diseases involving the vasculature. Thus, there has been interest in the effects of pharmacologic doses of L-arginine in patients with cardiovascular and renal diseases. To study the disposition of exogenous doses, an HPLC method was developed to analyze plasma samples for L-arginine. The assay involves precolumn derivatization of arginine with naphthalenedicarboxaldehyde and cyanide followed by HPLC with UV detection. Only a simple deproteinization of the plasma samples was required. The derivatized arginine was stable (less than 5% degradation in 20 h), facilitating batch sample processing and analysis in an autosampler. Calibration curves were generated in Ringer's lactate solution instead of plasma to correct for endogenous plasma L-arginine. Recovery in plasma, compared to Ringer's solution (n = 4), was 103%. Mean intraday assay precision (n = 6), expressed as coefficient of variation, was 3.4%. Interassay precision (n = 6) was 7%. The assay was applied for the quantitation of L-arginine in plasma samples from a normal subject who had been given a single oral (10 g) and a single intravenous dose (30 g) of exogenous L-arginine. PMID:8843144

  7. Plasma scale-length effects on electron energy spectra in high-irradiance laser plasmas

    NASA Astrophysics Data System (ADS)

    Culfa, O.; Tallents, G. J.; Rossall, A. K.; Wagenaars, E.; Ridgers, C. P.; Murphy, C. D.; Dance, R. J.; Gray, R. J.; McKenna, P.; Brown, C. D. R.; James, S. F.; Hoarty, D. J.; Booth, N.; Robinson, A. P. L.; Lancaster, K. L.; Pikuz, S. A.; Faenov, A. Ya.; Kampfer, T.; Schulze, K. S.; Uschmann, I.; Woolsey, N. C.

    2016-04-01

    An analysis of an electron spectrometer used to characterize fast electrons generated by ultraintense (1020W cm-2 ) laser interaction with a preformed plasma of scale length measured by shadowgraphy is presented. The effects of fringing magnetic fields on the electron spectral measurements and the accuracy of density scale-length measurements are evaluated. 2D EPOCH PIC code simulations are found to be in agreement with measurements of the electron energy spectra showing that laser filamentation in plasma preformed by a prepulse is important with longer plasma scale lengths (>8 μ m ).

  8. Electrochemical properties of modified highly ordered pyrolytic graphite by using ambient plasma

    NASA Astrophysics Data System (ADS)

    Kim, Ho Jun; Yang, Cheol-Soo; Jeong, HaeKyung

    2016-01-01

    Surface of highly ordered pyrolytic graphite (HOPG) is reformed by using ambient plasma. The HOPG film shows various pore structures after the plasma treatment, indicating improved electrochemical properties for supercapacitor applications because of the increase of the surface area. We also compare water effect on the film during the plasma treatment. Water might protect HOPG surface from the plasma and provide oxygen functional groups onto it, resulting in lower infected pores and higher impedance compared with them of HOPG film without water. Ambient plasma, therefore, could be considered as an economic and effective method for sample reformations.

  9. Anticorrelated Emission of High Harmonics and Fast Electron Beams From Plasma Mirrors

    NASA Astrophysics Data System (ADS)

    Bocoum, Maïmouna; Thévenet, Maxence; Böhle, Frederik; Beaurepaire, Benoît; Vernier, Aline; Jullien, Aurélie; Faure, Jérôme; Lopez-Martens, Rodrigo

    2016-05-01

    We report for the first time on the anticorrelated emission of high-order harmonics and energetic electron beams from a solid-density plasma with a sharp vacuum interface—plasma mirror—driven by an intense ultrashort laser pulse. We highlight the key role played by the nanoscale structure of the plasma surface during the interaction by measuring the spatial and spectral properties of harmonics and electron beams emitted by a plasma mirror. We show that the nanoscale behavior of the plasma mirror can be controlled by tuning the scale length of the electron density gradient, which is measured in situ using spatial-domain interferometry.

  10. Characterization Of High Explosives Detonations Via Laser-Induced Plasmas

    SciTech Connect

    Villa-Aleman, E.

    2015-10-08

    One objective of the Department of Energy’s National Security Administration is to develop technologies that can help the United States government to detect foreign nuclear weapons development activities. The realm of high explosive (HE) experiments is one of the key areas to assess the nuclear ambitions of a country. SRNL has participated in the collection of particulates from HE experiments and characterized the material with the purpose to correlate particulate matter with HE. Since these field campaigns are expensive, on-demand simulated laboratory-scale explosion experiments are needed to further our knowledge of the chemistry and particle formation in the process. Our goal is to develop an experimental test bed in the laboratory to test measurement concepts and correlate particle formation processes with the observables from the detonation fireball. The final objective is to use this knowledge to tailor our experimental setups in future field campaigns. The test bed uses pulsed laser-induced plasmas to simulate micro-explosions, with the intent to study the temporal behavior of the fireball observed in field tests. During FY15, a plan was prepared and executed which assembled two laser ablation systems, procured materials for study, and tested a Step-Scan Fourier Transform Infrared Spectrometer (SS-FTIR). Designs for a shadowgraph system for shock wave analysis, design for a micro-particulate collector from ablated pulse were accomplished. A novel spectroscopic system was conceived and a prototype system built for acquisition of spectral/temporal characterization of a high speed event such as from a high explosive detonation. Experiments and analyses will continue into FY16.

  11. Plasma diagnostic approach for high rate nanocrystalline Si synthesis in RF/UHF hybrid plasmas using a PECVD process

    NASA Astrophysics Data System (ADS)

    Sahu, B. B.; Han, Jeon G.; Shin, Kyung S.; Ishikawa, K.; Hori, M.; Miyawaki, Yudai

    2015-04-01

    Hydrogenated nanocrystalline silicon (nc-Si : H) films intended for efficient nc-Si : H solar cells are usually made at the transition to the nanocrystalline regime using the plasma-enhanced chemical vapor deposition (PECVD) process. This change occurs within a sensitive process window and is affected by various deposition parameters. This paper reports a study of nc-Si : H films' fabrication by utilizing systematic plasma diagnostics. This work presents a novel approach for plasma processing using radio frequency (RF), ultra high frequency (UHF) and RF/UHF hybrid plasmas. Using careful analysis, efforts are made to investigate the radicals and plasma formation by changing the operating source power and silane (SiH4) concentration. The aim of this work is also to investigate the PECVD process and conditions favorable for the synthesis of nc-Si : H film. For the present study, we systematically use the optical emission spectroscopy (OES), normal, and RF-compensated Langmuir probe (LP) and vacuum ultraviolet absorption spectroscopy diagnostics. Measurements reveal that the OES diagnostic is consistent with the LP measurements. Investigation reveals that UHF power in addition to RF enables higher dissociation of H or SiH radicals and the production of higher plasma density. The combined effect of both RF and UHF sources is used as the hybrid plasma source. Measurements also reveal that inbetween SiH4 flow rates ˜20-30 sccm, there is significant change in the plasma characteristics that denotes the nc-Si : H-a-Si : H transition region. An atomic hydrogen density (nH) in the range ≈(8 - 10) × 1011 cm-3 and plasma density n0 ≈ (2 - 3) × 1011 cm-3 with a silane to hydrogen ratio of 1-2% with high crystallinity has been obtained. Along with the discussion on the effect of frequency on plasma chemistry, this explains the RF power coupling and the role of electrons and ions in plasmas with increasing frequency.

  12. Relationships (II) of International Classification of High-resolution Computed Tomography for Occupational and Environmental Respiratory Diseases with ventilatory functions indices for parenchymal abnormalities

    PubMed Central

    TAMURA, Taro; SUGANUMA, Narufumi; HERING, Kurt G.; VEHMAS, Tapio; ITOH, Harumi; AKIRA, Masanori; TAKASHIMA, Yoshihiro; HIRANO, Harukazu; KUSAKA, Yukinori

    2015-01-01

    The International Classification of High-Resolution Computed Tomography (HRCT) for Occupational and Environmental Respiratory Diseases (ICOERD) is used to screen and diagnose respiratory illnesses. Using univariate and multivariate analysis, we investigated the relationship between subject characteristics and parenchymal abnormalities according to ICOERD, and the results of ventilatory function tests (VFT). Thirty-five patients with and 27 controls without mineral-dust exposure underwent VFT and HRCT. We recorded all subjects’ occupational history for mineral dust exposure and smoking history. Experts independently assessed HRCT using the ICOERD parenchymal abnormalities (Items) grades for well-defined rounded opacities (RO), linear and/or irregular opacities (IR), and emphysema (EM). High-resolution computed tomography showed that 11 patients had RO; 15 patients, IR; and 19 patients, EM. According to the multiple regression model, age and height had significant associations with many indices ventilatory functions such as vital capacity, forced vital capacity, and forced expiratory volume in 1 s (FEV1). The EM summed grades on the upper, middle, and lower zones of the right and left lungs also had significant associations with FEV1 and the maximum mid-expiratory flow rate. The results suggest the ICOERD notation is adequate based on the good and significant multiple regression modeling of ventilatory function with the EM summed grades. PMID:25810443

  13. Hypertension, Abnormal Cholesterol, and High Body Mass Index among Non-Hispanic Asian Adults: United States, 2011-2012

    MedlinePlus

    ... high total cholesterol among non-Hispanic Asian adults did not differ by sex, age, education, or foreign- ... Figure 3 ). The prevalence of high total cholesterol did not differ significantly by sex, age, education, or ...

  14. Radial convection of finite ion temperature, high amplitude plasma blobs

    SciTech Connect

    Wiesenberger, M. Kendl, A.; Madsen, J.

    2014-09-15

    We present results from simulations of seeded blob convection in the scrape-off-layer of magnetically confined fusion plasmas. We consistently incorporate high fluctuation amplitude levels and finite Larmor radius (FLR) effects using a fully nonlinear global gyrofluid model. This is in line with conditions found in tokamak scrape-off-layers (SOL) regions. Varying the ion temperature, the initial blob width, and the initial amplitude, we found an FLR dominated regime where the blob behavior is significantly different from what is predicted by cold-ion models. The transition to this regime is very well described by the ratio of the ion gyroradius to the characteristic gradient scale length of the blob. We compare the global gyrofluid model with a partly linearized local model. For low ion temperatures, we find that simulations of the global model show more coherent blobs with an increased cross-field transport compared to blobs simulated with the local model. The maximal blob amplitude is significantly higher in the global simulations than in the local ones. When the ion temperature is comparable to the electron temperature, global blob simulations show a reduced blob coherence and a decreased cross-field transport in comparison with local blob simulations.

  15. Progress on Development of Low Pressure High Density Plasmas on the Helicon Plasma Experiment (HPX)

    NASA Astrophysics Data System (ADS)

    Azzari, Phillip; Hopson, Jordan; Crilly, Paul; Duke-Tinson, Omar; Karama, Jackson; Paolino, Richard; Sandri, Eva; Sherman, Justin; Wright, Erin; Frank, John; Turk, Jeremy

    2015-11-01

    HPX Plasmas are created by imparting directed energy into a Pyrex tube preloaded with Ar gas at fill pressures on the order of 104 mTorr utilizing an RF power supply and matching box that can deliver about 250 W of power in the 20 MHz to 100 MHz frequency range. It has been demonstrated that a uniform magnetic field in lower energy level plasmas can facilitate a decrease in inertial effects, which promotes energy conservation within the plasma to provide the necessary external energy in the plasma's magnetic field required to reach the Helicon Mode. This uniform magnetic field will be created by a set of electromagnets capable of producing 1000 gauss. These electromagnets, provided by Princeton Plasma Physics Laboratory will facilitate W-mode production. After reaching the Helicon Mode, the plasma must be forced along the Pyrex tube by an acceleration coil in order to come in contact with several diagnostic probes and to be propelled into a viewing port so Thompson Scattering can be conducted. The progress on the development of the acceleration coil and electromagnets will be presented. Supported by U.S. DEPS Grant [HEL-JTO] PRWJFY15.

  16. High Power Dynamic Polarization Control Using Plasma Photonics.

    PubMed

    Turnbull, D; Michel, P; Chapman, T; Tubman, E; Pollock, B B; Chen, C Y; Goyon, C; Ross, J S; Divol, L; Woolsey, N; Moody, J D

    2016-05-20

    We report the first experimental demonstration of a plasma wave plate based on laser-induced birefringence. An elliptically polarized input was converted into a nearly ideal circularly polarized beam using an optical system composed of a second laser beam and a plasma. The results are in excellent agreement with linear theory and three-dimensional simulations up to phase delays exceeding π/4, thus establishing the feasibility of laser-plasma photonic devices that are ultrafast, damage-resistant, and easily tunable. PMID:27258871

  17. High-frequency electrostatic modes in non-neutral plasmas

    NASA Astrophysics Data System (ADS)

    Book, David L.

    1995-05-01

    A fluid description is employed to derive the dispersion relation for cyclotron modes in a cylindrical non-neutral plasma of radius R confined by a uniform magnetic field B=B0ez inside a chamber with conducting walls of radius R0. In contrast to the theory of Gould and LaPointe [Phys. Rev. Lett. 67, 3685 (1991); Phys. Fluids B 4, 2038 (1992)] the model includes the diamagnetic drift but omits finite Larmor radius effects. The density and the temperature of the unperturbed state are taken to be n(r)=n0(1-r2/R2) and T(r)=T0(1-r2/R2)γ-1, where γ is the adiabatic index, so that the r-dependent slow rotation frequency is ωr≊-[δ(1-r2/2R2)+ɛ(1-r2/R2)γ-2]Ω/2, where Ω=qB0/Mc is the ion gyrofrequency, δ=4πn0q2/MΩ2, and ɛ=4γT0/MΩ2R2. For the linearized fluid equations together with the Poisson equation the eigenvalue problem is solved in the limit δ≪1, ɛ≪1. The eigenfrequencies for high-frequency electrostatic modes with wave vectors satisfying kṡB=0 (Bernstein modes) are found in the form ω=-Ω+Δω, where Δω/Ω contains terms proportional to δ and ɛ. Solutions are obtained and compared with experiment and the theory of Gould and LaPointe. The present theory predicts that at a given T0 modes with m≳1 propagate only when the density is less than a critical value that increases with m, and that Δω normalized by the diocotron frequency depends only on the ratio of the Debye length to the plasma radius and hence is independent of B and M. The predictions of the two theories differ in several other respects; future observations may serve to decide between them.

  18. Energy Loss of a High Charge Bunched Electron Beam in Plasma: Nonlinear Plasma Response and Linear Scaling

    NASA Astrophysics Data System (ADS)

    Rosenzweig, J. B.; Barov, N.; Thompson, M. C.; Yoder, R.

    2002-12-01

    There has been much experimental and theoretical interest in blowout regime of plasma wakefield acceleration (PWFA), which features ultra-high accelerating fields, linear transverse focusing forces, and nonlinear plasma motion. Using an exact analysis, we examine here a fundamental limit of nonlinear PWFA excitation, by an infinitesimally short, relativistic electron beam. The beam energy loss in this case is shown to be linear in charge even for nonlinear plasma response, where a normalized, unitless charge exceeds unity, and relativistic plasma effects become important or dominant. The physical bases for this persistence of linear response are pointed out. As a byproduct of our analysis, we re-examine the issue of field divergence as the point-charge limit is approached, suggesting an important modification of commonly held views of evading unphysical energy loss. Deviations from linear behavior are investigated using simulations with finite length beams. The peak accelerating field in the plasma wave excited behind a finite-length beam is also examined, with the artifact of wave spiking adding to the apparent persistence of linear scaling of the peak field amplitude well into the nonlinear regime. On the other hand, at large enough normalized charge, linear scaling of fields collapses, with serious consequences for plasma wave excitation efficiency. The dramatic implications of these results for observing the collapse of linear scaling in planned experiments are discussed.

  19. Plasma (Accretion) Disks with High Magnetic Energy Densities

    NASA Astrophysics Data System (ADS)

    Rousseau, F.; Coppi, B.

    2006-04-01

    ``Corrugated'' plasma disks can form in the dominant gravity of a central object when the peak plasma pressure in the disk is of the same order as that of the pressure of the ``external'' magnetic field, while the magnetic field resulting from internal plasma currents is of the same order as the external field. The corrugation refers to a periodic variation of the plasma density in a region around the equatorial plane. The considered structure represents a transition between a ``classical'' accretion disk and a ``rings sequence'' configuration^2. The common feature of the ``corrugated'' and the ``rings sequence'' configurations is the ``crystal'' structure of the magnetic surfaces that consist of a sequence of pairs of oppositely directed toroidal current density filaments. The connection between the characteristics of these configurations and those of the marginally stable ballooning modes that can be found in a model accretion disk is pointed out and analyzed.

  20. Spectroscopic diagnostics of high temperature plasmas. [Annual report

    SciTech Connect

    Moos, W.

    1990-12-31

    A three-year research program for the development of novel XUV spectroscopic diagnostics for magnetically confined fusion plasmas is proposed. The new diagnostic system will use layered synthetic microstructures (LSM) coated, flat and curved surfaces as dispersive elements in spectrometers and narrow band XUV filter arrays. In the framework of the proposed program we will develop impurity monitors for poloidal and toroidal resolved measurements on PBX-M and Alcator C-Mod, imaging XUV spectrometers for electron density and temperature fluctuation measurements in the hot plasma core in TEXT or other similar tokamaks and plasma imaging devices in soft x-ray light for impurity behavior studies during RF heating on Phaedrus T and carbon pellet ablation in Alcator C-Mod. Recent results related to use of multilayer in XUV plasma spectroscopy are presented. We also discuss the latest results reviewed to q{sub o} and local poloidal field measurements using Zeeman polarimetry.

  1. High power impulse magnetron sputtering and related discharges: scalable plasma sources for plasma-based ion implantation and deposition

    SciTech Connect

    Anders, Andre

    2009-09-01

    High power impulse magnetron sputtering (HIPIMS) and related self-sputtering techniques are reviewed from a viewpoint of plasma-based ion implantation and deposition (PBII&D). HIPIMS combines the classical, scalable sputtering technology with pulsed power, which is an elegant way of ionizing the sputtered atoms. Related approaches, such as sustained self-sputtering, are also considered. The resulting intense flux of ions to the substrate consists of a mixture of metal and gas ions when using a process gas, or of metal ions only when using `gasless? or pure self-sputtering. In many respects, processing with HIPIMS plasmas is similar to processing with filtered cathodic arc plasmas, though the former is easier to scale to large areas. Both ion implantation and etching (high bias voltage, without deposition) and thin film deposition (low bias, or bias of low duty cycle) have been demonstrated.

  2. Plasma diagnostics of low pressure high power impulse magnetron sputtering assisted by electron cyclotron wave resonance plasma

    SciTech Connect

    Stranak, Vitezslav; Herrendorf, Ann-Pierra; Drache, Steffen; Bogdanowicz, Robert; Hippler, Rainer; Cada, Martin; Hubicka, Zdenek; Tichy, Milan

    2012-11-01

    This paper reports on an investigation of the hybrid pulsed sputtering source based on the combination of electron cyclotron wave resonance (ECWR) inductively coupled plasma and high power impulse magnetron sputtering (HiPIMS) of a Ti target. The plasma source, operated in an Ar atmosphere at a very low pressure of 0.03 Pa, provides plasma where the major fraction of sputtered particles is ionized. It was found that ECWR assistance increases the electron temperature during the HiPIMS pulse. The discharge current and electron density can achieve their stable maximum 10 {mu}s after the onset of the HiPIMS pulse. Further, a high concentration of double charged Ti{sup ++} with energies of up to 160 eV was detected. All of these facts were verified experimentally by time-resolved emission spectroscopy, retarding field analyzer measurement, Langmuir probe, and energy-resolved mass spectrometry.

  3. Submillimeter laser interferometer for high density plasma diagnostic

    NASA Astrophysics Data System (ADS)

    Kamenev, Yu. E.; Kiselyev, V. K.; Kuleshov, E. M.; Knyaz'kov, B. N.; Kononenko, V. K.; Nesterov, P. K.; Yanovsky, M. S.

    1995-06-01

    There are presented the results of investigation of the one-channel homodyne laser interferometer λ=119 µm made on the basis of the hollow dielectric beamguide and quasioptical functional devices. The interferometer is designed for determination of the plasma electron density of the TOKAMAK-7. The density response threshold is 0.7% from the expected plasma density and the phase difference measurement total error is 5°

  4. Laminar shocks in high power laser plasma interactions

    SciTech Connect

    Cairns, R. A.; Bingham, R.; Norreys, P.; Trines, R.

    2014-02-15

    We propose a theory to describe laminar ion sound structures in a collisionless plasma. Reflection of a small fraction of the upstream ions converts the well known ion acoustic soliton into a structure with a steep potential gradient upstream and with downstream oscillations. The theory provides a simple interpretation of results dating back more than forty years but, more importantly, is shown to provide an explanation for recent observations on laser produced plasmas relevant to inertial fusion and to ion acceleration.

  5. An atmospheric-pressure, high-aspect-ratio, cold micro-plasma

    PubMed Central

    Lu, X.; Wu, S.; Gou, J.; Pan, Y.

    2014-01-01

    An atmospheric pressure nonequilibrium Ar micro-plasma generated inside a micro-tube with plasma radius of 3 μm and length of 2.7 cm is reported. The electron density of the plasma plume estimated from the broadening of the Ar emission line reaches as high as 3 × 1016 cm−3. The electron temperature obtained from CR model is 1.5 ev while the gas temperature of the plasma estimated from the N2 rotational spectrum is close to room temperature. The sheath thickness of the plasma could be close to the radius of the plasma. The ignition voltages of the plasma increase one order when the radius of the dielectric tube is decreased from 1 mm to 3 μm. PMID:25502006

  6. Measurement of RF electric field in high- β plasma using a Pockels detector in magnetosphere plasma confinement device RT-1

    NASA Astrophysics Data System (ADS)

    Mushiake, Toshiki; Nishiura, M.; Yoshida, Z.; Yano, Y.; Kawazura, Y.; Saitoh, H.; Yamasaki, M.; Kashyap, A.; Takahashi, N.; Nakatsuka, M.; Fukuyama, Atsushi

    2015-11-01

    The magnetosphere plasma confinement device RT-1 generates a dipole magnetic field that can confine high- β plasma by using a levitated superconducting coil. So far it is reported that high temperature electrons (up to 50keV) exist and that the local electron βe value exceeds more than 100%. However, the ion β value βi remains low in the present high- β state. To realize a high-βi state, we have started Ion Cyclotron Heating (ICH) experiments. For efficient ICH in a dipole topology, it is important to measure RF electric fields and characterize the propagation of RF waves in plasmas. On this viewpoint, we started direct measurement of local RF electric fields in RT-1 with a Pockels sensor system. A non-linear optical crystal in the Pockels sensor produces birefringence in an ambient electric field. The refractive index change of the birefringence is proportional to the applied electric field strength, which can be used to measure local electric fields. RF electric field distribution radiated from an ICH antenna was measured inside RT-1 in air, and was compared with numerical results calculated by TASK code. Results on the measurement of electric field distribution in high- β plasma and evaluation of the absorbed RF power into ions will be reported. Supported by JSPS KAKENHI Grant Numbers 23224014.

  7. Transpulmonary plasma ET-1 and nitrite differences in high altitude pulmonary hypertension.

    PubMed

    Berger, Marc M; Dehnert, Christoph; Bailey, Damian M; Luks, Andrew M; Menold, Elmar; Castell, Christian; Schendler, Guido; Faoro, Vitalie; Mairbäurl, Heimo; Bärtsch, Peter; Swenson, Erik R

    2009-01-01

    Berger, Marc M., Christoph Dehnert, Damian M. Bailey, Andrew M. Luks, Elmar Menold, Christian Castell, Guido Schendler, Vitalie Faoro, Heimo Mairbäurl, Peter Bärtsch, and Eric R. Swenson. Transpulmonary plasma ET-1 and nitrite differences in high altitude pulmonary hypertension. High Alt. Med. Biol. 10:17-24, 2009.- Thirty-four mountaineers were studied at low (110 m) and high altitude (4559 m) to evaluate if increased pulmonary artery systolic pressure (PASP) at high altitude is associated with increased pulmonary endothelin-1 (ET-1) availability and alterations in nitrite metabolism across the lung. Blood samples were obtained using central venous and radial artery catheters for plasma ET-1 and nitrite. Pulmonary blood flow was measured by inert gas rebreathing to calculate transpulmonary exchange of plasma ET-1 and nitrite, and PASP was assessed by transthoracic Doppler echocardiography. After ascent to high altitude, PASP increased from 23 +/- 4 to 39 +/- 10 mmHg. Arterial and central venous plasma ET-1 increased, while plasma nitrite did not change significantly. At low altitude there was a transpulmonary loss of plasma ET-1, but a transpulmonary gain at high altitude. In contrast was a transpulmonary gain of plasma nitrite at low altitude and a transpulmonary loss at high altitude. PASP positively correlated with a transpulmonary gain of plasma ET-1 and negatively correlated with a transpulmonary loss of plasma nitrite. These results suggest that a transpulmonary gain of plasma ET- 1 is associated with higher PASP at high altitude. Transpulmonary loss of plasma nitrite indicates either less pulmonary nitric oxide (NO) production, which contributes to higher PASP, or increased NO bioavailability arising from nitrite reduction, which may oppose ET-1-mediated vasoconstriction. PMID:19326597

  8. Design of a high particle flux hydrogen helicon plasma source for used in plasma materials interaction studies

    SciTech Connect

    Goulding, R. H.; Chen, G.; Meitner, S.; Baity, F. W.; Caughman, J. B. O.; Owen, L.

    2009-11-26

    Existing linear plasma materials interaction (PMI) facilities all use plasma sources with internal electrodes. An rf-based helicon source is of interest because high plasma densities can be generated with no internal electrodes, allowing true steady state operation with minimal impurity generation. Work has begun at Oak Ridge National Laboratory (ORNL) to develop a large (15 cm) diameter helicon source producing hydrogen plasmas with parameters suitable for use in a linear PMI device: n{sub e}{>=}10{sup 19} m{sup -3}, T{sub e} = 4-10 eV, particle flux {gamma}{sub p}>10{sup 23}m{sup -3} s{sup -1}, and magnetic field strength |B| up to 1 T in the source region. The device, whose design is based on a previous hydrogen helicon source operated at ORNL[1], will operate at rf frequencies in the range 10-26 MHz, and power levels up to {approx}100 kW. Limitations in cooling will prevent operation for pulses longer than several seconds, but a major goal will be the measurement of power deposition on device structures so that a later steady state version can be designed. The device design, the diagnostics to be used, and results of rf modeling of the device will be discussed. These include calculations of plasma loading, resulting currents and voltages in antenna structures and the matching network, power deposition profiles, and the effect of high |B| operation on power absorption.

  9. Design of a high particle flux hydrogen helicon plasma source for used in plasma materials interaction studies

    SciTech Connect

    Goulding, Richard Howell; Chen, Guangye; Meitner, Steven J; Baity Jr, F Wallace; Caughman, John B; Owen, Larry W

    2009-01-01

    Existing linear plasma materials interaction (PMI) facilities all use plasma sources with internal electrodes. An rf-based helicon source is of interest because high plasma densities can be generated with no internal electrodes, allowing true steady state operation with minimal impurity generation. Work has begun at Oak Ridge National Laboratory (ORNL) to develop a large (15 cm) diameter helicon source producing hydrogen plasmas with parameters suitable for use in a linear PMI device: n(e) >= 10(19)m(-3), T(e) = 4-10 eV, particle flux Gamma(p) > 10(23) m(-3) s(-1), and magnetic field strength |B| up to I T in the source region. The device, whose design is based on a previous hydrogen helicon source operated at ORNL[1], will operate at rf frequencies in the range 10 - 26 MHz, and power levels up to similar to 100 kW. Limitations in cooling will prevent operation for pulses longer than several seconds, but a major goal will be the measurement of power deposition on device structures so that a later steady state version can be designed. The device design, the diagnostics to be used, and results of rf modeling of the device will be discussed. These include calculations of plasma loading, resulting currents and voltages in antenna structures and the matching network, power deposition profiles, and the effect of high |B| operation on power absorption.

  10. Particle and field characteristics of the high-latitude plasma sheet boundary layer

    NASA Technical Reports Server (NTRS)

    Parks, G. K.; Mccarthy, M.; Fitzenreiter, R. J.; Ogilvie, K. W.; Etcheto, J.; Anderson, K. A.; Lin, R. P.; Anderson, R. R.; Eastman, T. E.; Frank, L. A.

    1984-01-01

    Particle and field data obtained by eight ISEE spacecraft experiments are used to define more precisely the characteristics of the high-latitude boundary region of the plasma sheet. A region immediately adjacent to the high-latitude plasma sheet boundary has particle and field characteristics distinctly different from those observed in the lobe and deeper in the central plasma sheet. Electrons over a broad energy interval are 'field-aligned' and bidirectional, whereas in the plasma sheet the distributions are more isotropic. The region supports intense ion flows, large-amplitude electric fields, and enhanced broad-band electrostatic noise.

  11. New high temperature plasmas and sample introduction systems for analytical atomic emission and mass spectrometry

    SciTech Connect

    Montaser, A.

    1992-01-01

    New high temperature plasmas and new sample introduction systems are explored for rapid elemental and isotopic analysis of gases, solutions, and solids using mass spectrometry and atomic emission spectrometry. Emphasis was placed on atmospheric pressure He inductively coupled plasmas (ICP) suitable for atomization, excitation, and ionization of elements; simulation and computer modeling of plasma sources with potential for use in spectrochemical analysis; spectroscopic imaging and diagnostic studies of high temperature plasmas, particularly He ICP discharges; and development of new, low-cost sample introduction systems, and examination of techniques for probing the aerosols over a wide range. Refs., 14 figs. (DLC)

  12. Achieving a long-lived high-beta plasma state by energetic beam injection.

    PubMed

    Guo, H Y; Binderbauer, M W; Tajima, T; Milroy, R D; Steinhauer, L C; Yang, X; Garate, E G; Gota, H; Korepanov, S; Necas, A; Roche, T; Smirnov, A; Trask, E

    2015-01-01

    Developing a stable plasma state with high-beta (ratio of plasma to magnetic pressures) is of critical importance for an economic magnetic fusion reactor. At the forefront of this endeavour is the field-reversed configuration. Here we demonstrate the kinetic stabilizing effect of fast ions on a disruptive magneto-hydrodynamic instability, known as a tilt mode, which poses a central obstacle to further field-reversed configuration development, by energetic beam injection. This technique, combined with the synergistic effect of active plasma boundary control, enables a fully stable ultra-high-beta (approaching 100%) plasma with a long lifetime. PMID:25902924

  13. High Resolution Plasma Measurements From The Fast Plasma Investigation On Magnetospheric Multiscale

    NASA Astrophysics Data System (ADS)

    Pollock, C. J.

    2015-12-01

    NASA's Magnetospheric Multiscale (MMS) mission, launched in March 2015, targets understanding of the fundamental physics of magnetic reconnection using Earth's magnetosphere as a laboratory within which to study this naturally occurring process. The first mission phase, currently in progress, focuses on reconnection occurring at Earth's dayside magnetopause. The relevant electron and ion scale processes have never before been fully resolved and differentiated, owing to limitations in the time (thus spatial) resolution available. The Fast Plasma Investigation (FPI) was developed for flight on MMS in order to fully resolve 3D plasma distribution functions on both the ion scale and the substantially smaller electron scale. MMS is designed to provide multi-point measurements of fast plasma, electric and magnetic fields, ion composition and energetic particles at the four points of a variably sized tetrahedron. Thus, MMS enables specification of all relevant plasma parameters and their spatial derivatives in order to understand the roles of the various terms in the Generalized Ohm's Law that governs the plasma behavior at reconnection sites. In this talk, we provide a brief description of FPI and show a sampling of early results, including MMS crossings of the magnetopause.

  14. Critical particle circulation caused by high-performance steady-state plasma discharge

    NASA Astrophysics Data System (ADS)

    Kasahara, Hiroshi

    2015-11-01

    Steady-state operation focused on the fusion reactor has been investigated in magnetic confined fusion devices, and plasma performance and duration time are steadily extended by the improvement of the quality of plasma heating and sophisticating plasma operation using the understanding of long-pulse plasma experiments. When higher-performance helium steady-state plasma discharges with duration time over 40 min, electron density of 1.2x1019 m-3, ion and electron temperatures over 2 keV and heating power of 1.2MW were repeatedly achieved in LHD, time-evolution of the wall-pumping and increasing frequency of impurity contaminations around the plasma edge clearly occurred. These are strongly related to the increasing mixed-material layer caused by continuous divertor erosion around geometrical dense divertor plates, which consists of carbon (> 90%) and iron (< a few %) with amorphous structure, that can retain the helium particles and affect the particle balance in long-pulse discharges. The mixed-material layer is easily exfoliated by the thermal stress and helium explosion in the layer, and small pieces of exfoliation enter the plasma edge in all toroidal sections. Uncontrolled flake contamination was one of the causes of plasma termination in long-pulse experiments. Increased plasma performance using higher heating power (~ 3.3 MW) with high quality makes robust plasma against impurity contaminations, and then a small amount of contamination of mixed-material does not terminate the helium plasma. Carbon impurity was circulated from the divertor plates and around the plates to the plasma edge in long-pulse plasma discharges, and the circulation was increased by the plasma duration and performance. The eroded material plays an important role in degrading the plasma performance as an impurity source and in the controllability of particle fueling in long-pulse discharges.

  15. Simulative research on the expansion of cathode plasma in high-current electron beam diode

    SciTech Connect

    Xu Qifu; Liu Lie

    2012-09-15

    The expansion of cathode plasma has long been recognized as a limiting factor in the impedance lifetime of high-current electron beam diode. Realistic modeling of such plasma is of great necessity in order to discuss the dynamics of cathode plasma. Using the method of particle-in-cell, the expansion of cathode plasma is simulated in this paper by a scaled-down diode model. It is found that the formation of cathode plasma increases the current density in the diode. This consequently leads to the decrease of the potential at plasma front. Once the current density has been increased to a certain value, the potential at plasma front would then be equal to or lower than the plasma potential. Then the ions would move towards the anode, and the expansion of cathode plasma is thereby formed. Different factors affecting the plasma expansion velocity are discussed in this paper. It is shown that the decrease of proton genatation rate has the benefit of reducing the plasma expansion velocity.

  16. Numerical Studies of Electrode Plasma Formation and Expansion in High Power Charged Particle Beam Diodes

    NASA Astrophysics Data System (ADS)

    Rittersdorf, I. M.; Swanekamp, S. B.; Richardson, A. S.; Allen, R. J.; Schumer, J. W.

    2014-10-01

    High-power diodes that generate intense electron beams are useful in many applications, such as producing x-rays for flash radiography and nuclear weapon effects simulations. Desorption and ionization of gases from electrodes can form a plasma during operation. Expansion of this plasma into the gap leads to a short circuit, which limits the radiation production. It is difficult for particle-in-cell codes to model the surface physics or the subsequent expansion of the plasma. NRL is beginning a multi-year research effort to study such plasmas. This paper will summarize the relevant literature on plasma formation in high-power diodes with a goal of developing dynamic models that describe the formation and expansion of these plasmas that are suitable for PIC codes. This work was supported by the NRL Basic and Applied Research Program.

  17. Glass Strengthening via High-Intensity Plasma-Arc Heating

    SciTech Connect

    Wereszczak, Andrew A; Harper, David C; Duty, Chad E; Patel, P

    2010-01-01

    The use of a high-intensity plasma-arc lamp was used to irradiate the surface of soda-lime silicate glass tiles to determine if an increase in strength could be achieved. The lamp had a power density of 3500 W/cm2, a processing area of 1 cm x 10 cm, irradiated near-infrared heating at a wavelength between 0.2 1.4 m, and was controlled to unidirectionally sweep across 50-mm-square tiles at a constant speed of 8 mm/s. Ring-on-ring (RoR) equibiaxial flexure and 4 pt uni-directional flexure testings of entire tiles were used to measure and compare failure stress distributions of treated and untreated glass. Even with non-optimized processing conditions, RoR failure stress increased by approximately 25% and the 4 pt bend failure stress increased by approximately 65%. Strengthening was due to a fire-polishing-like mechanism. The arc-lamp heat-treatment caused the location of the strength-limiting flaws in the 4-pt-bend tiles to change; namely, failure initiation occurred on the gage section surface for the treated glass whereas it occurred at a gage section edge for the untreated. Arc-lamp heat-treatment is attractive not only because it provides strengthening, but because it can (non-contact) process large amounts of glass quickly and inexpensively, and is a process that either a glass manufacturer or end-user can readily employ.

  18. Plasma effects in high harmonic spectra from ultrarelativistic laser-plasma interactions

    NASA Astrophysics Data System (ADS)

    Boyd, T. J. M.; Ondarza-Rovira, R.

    2016-03-01

    A single particle model has been applied to examine the competition between radiation from a strong Langmuir source and coherent bremsstrahlung in ultra-relativistic laser-plasma interactions. Output from this model shows generally satisfactory agreement with that from particle-in-cell (PIC) simulations, in particular reproducing spectra characterised by a decay index p = 5 / 3. At the highest intensities considered, both model and PIC spectra show the competing contribution from relativistic electron bremsstrahlung, characterised by a further relaxation in the decay index to p = 2 / 3. Combinations of laser and plasma parameters have been identified that define regions of parameter space where one or other emission is dominant.

  19. Interaction of high flux deuterium/nitrogen plasmas with beryllium

    NASA Astrophysics Data System (ADS)

    Dittmar, T.; Baldwin, M. J.; Doerner, R. P.; Nishijima, D.; Oberkofler, M.; Schwarz-Selinger, T.; Tabarés, F.

    2011-12-01

    Before nitrogen can be used as a radiator for edge plasma temperature control in experiments with beryllium as the wall material, the compatibility of nitrogen-containing plasma with beryllium has to be tested. Therefore beryllium samples were exposed to a variety of mixed N2/D2 plasmas in PISCES-B and codeposits from the sputtered material were collected. It was found that introducing N2 to a D2 plasma reduces Be erosion significantly but recovery to the pre-N2 levels is possible in pure D2 plasma. Berylliated vessel walls can be a reservoir for N2 and chemical processes probably play a significant role during nitriding and N2 removal. Nitrided target samples remain conductive and do not lead to additional arcing, but codeposits are insulating. Thermal desorption measurements of nitrided and un-nitrided target samples are comparable, while codeposits show a slightly reduced D retention. However, D release for both target and codeposits is shifted ≈100 K to higher temperatures, above 510 K.

  20. Interpretation of high-speed flows in the plasma sheet

    NASA Technical Reports Server (NTRS)

    Chen, C. X.; Wolf, R. A.

    1993-01-01

    Pursuing an idea suggested by Pontius and Wolf (1990), we propose that the `bursty bulk flows' observed by Baumjohann et al. (1990) and Angelopoulos et al. (1992) are `bubbles' in the Earth's plasma sheet. Specifically, they are flux tubes that have lower values of pV(exp 5/3) than their neighbors, where p is the thermal pressure of the particles and V is the volume of a tube containing one unit of magnetic flux. Whether they are created by reconnection or some other mechanism, the bubbles are propelled earthward by a magnetic buoyancy force, which is related to the interchange instability. Most of the major observed characteristics of the bursty bulk flows can be interpreted naturally in terms of the bubble picture. We propose a new `stratified fluid' picture of the plasma sheet, based on the idea that bubbles constitute the crucial transport mechanism. Results from simple mathematical models of plasma sheet transport support the idea that bubbles can resolve the pressure balance inconsistency, particularly in cases where plasma sheet ions are lost by gradient/curvature drift out the sides of the tail or bubbles are generated by reconnection in the middle of plasma sheet.

  1. Transport analysis of high radiation and high density plasmas in the ASDEX Upgrade tokamak

    NASA Astrophysics Data System (ADS)

    Casali, L.; Bernert, M.; Dux, R.; Fischer, R.; Kallenbach, A.; Kurzan, B.; Lang, P.; Mlynek, A.; McDermott, R. M.; Ryter, F.; Sertoli, M.; Tardini, G.; Zohm, H.

    2014-12-01

    Future fusion reactors, foreseen in the "European road map" such as DEMO, will operate under more demanding conditions compared to present devices. They will require high divertor and core radiation by impurity seeding to reduce heat loads on divertor target plates. In addition, DEMO will have to work at high core densities to reach adequate fusion performance. The performance of fusion reactors depends on three essential parameters: temperature, density and energy confinement time. The latter characterizes the loss rate due to both radiation and transport processes. The DEMO foreseen scenarios described above were not investigated so far, but are now addressed at the ASDEX Upgrade tokamak. In this work we present the transport analysis of such scenarios. Plasma with high radiation by impurity seeding: transport analysis taking into account the radiation distribution shows no change in transport during impurity seeding. The observed confinement improvement is an effect of higher pedestal temperatures which extend to the core via stiffness. A non coronal radiation model was developed and compared to the bolometric measurements in order to provide a reliable radiation profile for transport calculations. High density plasmas with pellets: the analysis of kinetic profiles reveals a transient phase at the start of the pellet fuelling due to a slower density build up compared to the temperature decrease. The low particle diffusion can explain the confinement behaviour.

  2. Pencil lead plasma for generating multimicrojoule high-order harmonics with a broad spectrum

    SciTech Connect

    Pertot, Y.; Elouga Bom, L. B.; Ozaki, T.; Bhardwaj, V. R.

    2011-03-07

    Using the plasma harmonic method, we show the generation of efficient and intense high-order harmonics from plasma of pencil lead. We demonstrate multimicrojoule energy in each harmonic order for the 11th to the 17th order of a Ti:sapphire laser. By analyzing the target morphology and the plasma composition, we conclude that these intense harmonics are generated from nanoparticles of graphitic carbon.

  3. Production of centimeter-scale, high-density plasmas with a linear gas jet

    SciTech Connect

    Coverdale, C.A.; Darrow, C.B.; Jones, R.; Sawyer, W.; Crane, J.; Ditmire, T.; Perry, M.D. ); Filbert, P.C. )

    1995-01-01

    A novel linear gas jet has been developed and used to produce centimeter-scale, 10[sup 19] cm[sup [minus]3] electron density plasmas. Long regions of high density are important to many types of experiments, including x-ray laser and laser-plasma interaction studies. This new type of gas jet has been characterized by stimulated Raman backscatter emission from the plasma.

  4. Plasma simulations of emission line regions in high energy environments

    NASA Astrophysics Data System (ADS)

    Richardson, Chris T.

    This dissertation focuses on understanding two different, but in each case extreme, astrophysical environments: the Crab Nebula and emission line galaxies. These relatively local objects are well constrained by observations and are test cases of phenomena seen at high-z where detailed observations are rare. The tool used to study these objects is the plasma simulation code known as Cloudy. The introduction provides a brief summary of relevant physical concepts in nebular astrophysics and presents the basic features and assumptions of Cloudy. The first object investigated with Cloudy, the Crab Nebula, is a nearby supernova remnant that previously has been subject to photoionization modeling to reproduce the ionized emission seen in the nebula's filamentary structure. However, there are still several unanswered questions: (1) What excites the H2 emitting gas? (2) How much mass is in the molecular component? (3) How did the H2 form? (4) What is nature of the dust grains? A large suite of observations including long slit optical and NIR spectra over ionized, neutral and molecular gas in addition to HST and NIR ground based images constrain a particularly bright region of H2 emission, Knot 51, which exhibits a high excitation temperature of ˜3000 K. Simulations of K51 revealed that only a trace amount of H2 is needed to reproduce the observed emission and that H2 forms through an uncommon nebular process known as associative detachment. The final chapters of this dissertation focus on interpreting the narrow line region (NLR) in low-z emission line galaxies selected by a novel technique known as mean field independent component analysis (MFICA). A mixture of starlight and radiation from an AGN excites the gas present in galaxies. MFICA separates galaxies over a wide range of ionization into subsets of pure AGN and pure star forming galaxies allowing simulations to reveal the properties responsible for their observed variation in ionization. Emission line ratios can

  5. [Selenium determination in blood plasma samples of high performance athletes].

    PubMed

    Logemann, E; Krützfeldt, B; Rokitzki, L

    1989-01-01

    Cooperating with the department "Sport- und Leistungsmedizin" of the university hospital of Freiburg/Brsg. we investigated the problem whether endurance stress leads to a significant change in the selenium blood concentration of athletes. We took blood samples of 13 test persons (11 men, 2 women) before, immediately after and 2 hours following a marathon course. The analyses of the concentration of selenium in plasma were performed by atomic absorption spectrometry AAS (molybdenum-coated graphite tube technique with L'vov platform as well as matrix modification with nickel nitrate in order to thermally stabilize the selenium). The selenium level of the plasma samples ranged between 41 and 153 micrograms/L. Our experiments have shown that running a marathon course does not lead to significant changes in the standard selenium plasma concentrations of the athletes. PMID:2818554

  6. Component Framework for Loosely Coupled High Performance Integrated Plasma Simulations

    NASA Astrophysics Data System (ADS)

    Elwasif, W. R.; Bernholdt, D. E.; Shet, A. G.; Batchelor, D. B.; Foley, S.

    2010-11-01

    We present the design and implementation of a component-based simulation framework for the execution of coupled time-dependent plasma modeling codes. The Integrated Plasma Simulator (IPS) provides a flexible lightweight component model that streamlines the integration of stand alone codes into coupled simulations. Standalone codes are adapted to the IPS component interface specification using a thin wrapping layer implemented in the Python programming language. The framework provides services for inter-component method invocation, configuration, task, and data management, asynchronous event management, simulation monitoring, and checkpoint/restart capabilities. Services are invoked, as needed, by the computational components to coordinate the execution of different aspects of coupled simulations on Massive parallel Processing (MPP) machines. A common plasma state layer serves as the foundation for inter-component, file-based data exchange. The IPS design principles, implementation details, and execution model will be presented, along with an overview of several use cases.

  7. High-Beta Electromagnetic Turbulence in LAPD Plasmas

    NASA Astrophysics Data System (ADS)

    Rossi, G.; Carter, T. A.; Pueschel, M. J.; Jenko, F.; Told, D.; Terry, P. W.

    2015-11-01

    The introduction of a new LaB6 cathode plasma source in the Large Plasma Device has enabled the study of pressure-gradient-driven turbulence and transport variations at significantly higher plasma β. Density fluctuations are observed to decrease with increasing β while magnetic fluctuations increase. Furthermore, the perpendicular magnetic fluctuations are seen to saturate while parallel (compressional) magnetic fluctuations increase continuously with β. These observations are compared to linear and nonlinear simulations with the GENE code. The results are consistent with the linear excitation of a Gradient-driven Drift Coupling mode (GDC) which relies on grad-B drift due to parallel magnetic fluctuations and can be driven by density or temperature gradients.

  8. Modeling Nuclear Fusion in High Energy Density Plasmas Using a Strongly Magnetized Non-neutral Plasma

    NASA Astrophysics Data System (ADS)

    Dubin, D. H. E.

    2005-10-01

    In the hot dense interiors of stars and giant planets, nuclear reactions are predicted to occur at rates that are greatly enhanced compared to those at low densities. The enhancement is caused by plasma screening of the reacting pairs, increasing the probability of close collisions. However, strongly enhanced nuclear reaction rates have never been observed in the laboratory. This poster discusses a method for observing the enhancement using an analogy between nuclear energy and cyclotron energy in a non-neutral plasma in a strong magnetic field. In such a plasma, cyclotron energy is an adiabatic invariant, and is released only through close collisions that break this invariant. It is shown that the rate of release of cyclotron energy is enhanced by precisely the same factor as that for the release of nuclear energy, because both processes rely on close collisions that are enhanced by plasma screening.ootnotetextD. Dubin, Phys. Rev. Lett. 94, 025002 (2005). Simulations measuring the screening enhancement will be presented, and the possibility of exciting and studying burn fronts will be discussed.ootnotetextSee also adjacent poster by J. Bollinger.

  9. Abnormal Functional Specialization within Medial Prefrontal Cortex in High-Functioning Autism: A Multi-Voxel Similarity Analysis

    ERIC Educational Resources Information Center

    Gilbert, Sam J.; Meuwese, Julia D. I.; Towgood, Karren J.; Frith, Christopher D.; Burgess, Paul W.

    2009-01-01

    Multi-voxel pattern analyses have proved successful in "decoding" mental states from fMRI data, but have not been used to examine brain differences associated with atypical populations. We investigated a group of 16 (14 males) high-functioning participants with autism spectrum disorder (ASD) and 16 non-autistic control participants (12 males)…

  10. Interaction of high-energy trapped particles with ballooning modes in a tokamak with a high-. beta. plasma

    SciTech Connect

    Mikhailovskii, A. B.; Novakovaskii, S. V.; Smolyakov, A. I.

    1988-12-01

    A theory is derived for the interaction of high-energy trapped particleswith ballooning modes in a tokamak with a high-..beta.. plasma. A dispersionrelation is derived to describe the ballooning modes in the presence ofsuch particles; the effects of the high plasma ..beta.. are taken into account.The stability boundary for ballooning modes with zero and finite frequenciesis studied. The effects of finite bananas on the stability of ballooningmodes with zero frequencies are determined.

  11. Eye movement abnormalities.

    PubMed

    Moncayo, Jorge; Bogousslavsky, Julien

    2012-01-01

    Generation and control of eye movements requires the participation of the cortex, basal ganglia, cerebellum and brainstem. The signals of this complex neural network finally converge on the ocular motoneurons of the brainstem. Infarct or hemorrhage at any level of the oculomotor system (though more frequent in the brain-stem) may give rise to a broad spectrum of eye movement abnormalities (EMAs). Consequently, neurologists and particularly stroke neurologists are routinely confronted with EMAs, some of which may be overlooked in the acute stroke setting and others that, when recognized, may have a high localizing value. The most complex EMAs are due to midbrain stroke. Horizontal gaze disorders, some of them manifesting unusual patterns, may occur in pontine stroke. Distinct varieties of nystagmus occur in cerebellar and medullary stroke. This review summarizes the most representative EMAs from the supratentorial level to the brainstem. PMID:22377853

  12. Plasma flares in high power impulse magnetron sputtering

    SciTech Connect

    Ni, Pavel A.; Hornschuch, Christian; Panjan, Matjaz; Anders, Andre

    2012-11-26

    Self-organized ionization zones and associated plasma flares were recorded with fast cameras in side-on view. Flare velocities were estimated to be about 20 000 m/s suggesting that the local tangential field E{sub {xi}} is about 2000 V/m based on a concept where flare-causing electrons are initially ejected by E{sub {xi}} Multiplication-Sign B drift. At distances of 10 mm and greater from the target, where the electric field is very small, plasma flares are guided by the magnetic field B.

  13. Laser-plasma spectra of highly ionized fluorine

    NASA Technical Reports Server (NTRS)

    Feldman, U.; Doschek, G. A.; Nagel, D. J.; Behring, W. E.; Cowan, R. D.

    1974-01-01

    Lines between 11.3 and 17.2 A of lithium-like, helium-like, and hydrogen-like fluorine have been observed in spectra of laser-produced plasmas. These lines include nine members of the Lyman series of F IX; eight members of the principal series of F VIII; and satellite lines arising from doubly excited configurations of F VII and F VIII. Similar satellite lines of the abundant solar elements have been identified in soft X-ray spectra of solar flares. A wavelength list of fluorine lines is given, and physical conditions in the plasma are discussed.

  14. Prevalence of High-Risk Human Papillomavirus (HR-HPV) Genotypes and Multiple Infections in Cervical Abnormalities from Northern Xinjiang, China

    PubMed Central

    Du, Jingyun; Jiang, Jianjun; Jia, Xuesong; Chen, Chuangfu; Wang, Yuanzhi

    2016-01-01

    Multiple human papillomavirus (HPV) genotypes often coexist within the cervical epithelia and are frequently detected together in various grades of the cervical neoplasia. To date, only a few reports exist on multiple HPV infections of HPV in Xinjiang Uygur Autonomous Region (XUAR). In the present study, we investigated the prevalence of High-Risk HPV (HR-HPV) genotypes and multiple infections. Cervical cytology samples were collected from 428 women who presented cervical abnormalities. Genotyping of HPV was performed by polymerase chain reaction–sequencing based typing (PCR-SBT) using consensus primers and specific primers. Of them, 166 samples were positive for HPV according to PCR results using the consensus primers. These samples contained cervical abnormalities enriched with inflammation (n = 107), cervical intraepithelial neoplasia (CIN) I (n = 19), CINII-III (n = 9) and cervical cancer (n = 31). Of the 166 HPV positive samples as determined by PCR analysis, 151 were further typed by PCR-SBT using 19 pairs of genotype-specific primers. Using this method, 17 different HR-HPV genotypes were identified. The most frequently observed HPV genotypes were HPV16 (44.0%, 73/166), 53 (28.9%, 48/166), 52 (25.3%, 42/166), 58 (22.3%, 37/166) and 35 (17.5%, 29/166). The proportions of single and multiple infections in the HPV-positive specimens were 34.9% and 65.1%, respectively. Multiple HPV types were most prevalent in the inflammatory state (63.0%), followed by cervical cancer (24.1%), CINI (11.1%), and CINII-III (1.9%). The results of our data analyses suggested that i) multiple HPV infection is not necessarily correlated with the severity of cervical abnormalities; and ii) among the multiple HPV infections, double infections combined with HPV16 is the most common. In addition, L1 full-length sequences of the top five high-risk HPV genotypes were amplified and sequenced. According to the L1 sequence of the epidemic genotypes that were amplified, we found that these

  15. A high-resolution imaging x-ray crystal spectrometer for high energy density plasmas

    SciTech Connect

    Chen, Hui E-mail: bitter@pppl.gov; Magee, E.; Nagel, S. R.; Park, J.; Schneider, M. B.; Stone, G.; Williams, G. J.; Beiersdorfer, P.; Bitter, M. E-mail: bitter@pppl.gov; Hill, K. W.; Kerr, S.

    2014-11-15

    Adapting a concept developed for magnetic confinement fusion experiments, an imaging crystal spectrometer has been designed and tested for HED plasmas. The instrument uses a spherically bent quartz [211] crystal with radius of curvature of 490.8 mm. The instrument was tested at the Titan laser at Lawrence Livermore National Laboratory by irradiating titanium slabs with laser intensities of 10{sup 19}–10{sup 20} W/cm{sup 2}. He-like and Li-like Ti lines were recorded, from which the spectrometer performance was evaluated. This spectrometer provides very high spectral resolving power (E/dE > 7000) while acquiring a one-dimensional image of the source.

  16. Vescalagin from Pink Wax Apple [Syzygium samarangense (Blume) Merrill and Perry] Alleviates Hepatic Insulin Resistance and Ameliorates Glycemic Metabolism Abnormality in Rats Fed a High-Fructose Diet.

    PubMed

    Huang, Da-Wei; Chang, Wen-Chang; Wu, James Swi-Bea; Shih, Rui-Wen; Shen, Szu-Chuan

    2016-02-10

    This study investigates the ameliorative effect of vescalagin (VES) isolated from Pink wax apple fruit on hepatic insulin resistance and abnormal carbohydrate metabolism in high-fructose diet (HFD)-induced hyperglycemic rats. The results show that in HFD rats, VES significantly reduced the values of the area under the curve for glucose in an oral glucose tolerance test and the homeostasis model assessment of insulin resistance index. VES significantly enhanced the activity of hepatic antioxidant enzymes while reducing thiobarbituric acid-reactive substances in HFD rats. Western blot assay revealed that VES reduced hepatic protein expression involved in inflammation pathways while up-regulating expression of hepatic insulin signaling-related proteins. Moreover, VES up-regulated the expression of hepatic glycogen synthase and hepatic glycolysis-related proteins while down-regulating hepatic gluconeogenesis-related proteins in HFD rats. This study suggests some therapeutic potential of VES in preventing the progression of diabetes mellitus. PMID:26800576

  17. Tooth - abnormal shape

    MedlinePlus

    Hutchinson incisors; Abnormal tooth shape; Peg teeth; Mulberry teeth; Conical teeth ... The appearance of normal teeth varies, especially the molars. ... conditions. Specific diseases can affect tooth shape, tooth ...

  18. Tooth - abnormal shape

    MedlinePlus

    Hutchinson incisors; Abnormal tooth shape; Peg teeth; Mulberry teeth; Conical teeth ... from many different conditions. Specific diseases can affect tooth shape, tooth color, time of appearance, or absence ...

  19. High Performance Plasma Operation on DIII-D During Extended Periods Without Boronization

    SciTech Connect

    West, W P; Groth, M; Hyatt, A W; Jackson, G L; Wade, M R; Greenfield, C M; Politzer, P A

    2007-06-27

    High performance plasmas, including both hybrid and advanced tokamak (AT) bench-mark discharges, were shown to be highly repeatable in DIII-D over 6000 plasma-seconds of operation during the 2006 campaign with no intervening boron depositions or high temperature bakes. Hybrid and AT discharges with identical control targets were repeated after the initial boronization at the beginning of the 2006 campaign, and again just before and after a second boronization near the end of the 2006 campaign. After a long entry vent between the 2006 and 2007 campaigns, similar discharges were again repeated after the standard high temperature baking and plasma cleanup, but prior to a boronization. Performance metrics, such as {beta}, confinement quality, and density control, were extremely well repeated. A low performance daily reference shot (DRS) was also established as a routine monitor of impurity influx. Over the 2006 campaign, the DRS database indicated little to no secular increase in impurity content. Oxygen content and Ni line emission were higher after the intervening vent, but were still minor contributors to plasma contamination. This indicates that erosion of boron films used for wall conditioning will not be a limitation to establishing long pulse high performance discharges in the new generation of superconducting tokamaks if graphite is used as the primary plasma facing material. These results contrast with recent work in devices using high-Z metallic plasma facing materials, where very frequent refreshing of boron films is required for high performance plasma operation.

  20. Study on Electrodeless Electric Propulsion in High-Density Helicon Plasma with Permanent Magnets

    NASA Astrophysics Data System (ADS)

    Ishii, Takamichi; Ishii, Hiroki; Otsuka, Shuhei; Teshigahara, Naoto; Fujitsuka, Hiroaki; Waseda, Shimpei; Kuwahara, Daisuke; Shinohara, Shunjiro

    To establish electrodeless electric propulsion, we have been developing a new electrodeless plasma acceleration thruster using high-density helicon plasmas and permanent magnets, and characterizing them by, e.g., electrostatic and magnetic probes, a high-resolution spectrometer (measuring argon line intensity and line intensity ratio to derive plasma parameters), and a high-speed camera measurements (deriving radial distribution of electron density), in addition to a laser induced fluorescence (LIF) method to measure plasma flow velocity, where they are under development. Here, we will present preliminary acceleration methods using such as Rotating Magnetic Field coil and m = 0 coil along with results of various measurements mentioned above to estimate the plasma performance.

  1. A simple method to verify the opacity and equation of state of high-Z plasmas

    SciTech Connect

    Meng, Guangwei; Li, Jinghong; Yang, Jiamin; Zhu, Tuo; Zou, Shiyang; Wang, Min; Zhang, Weiyan

    2013-09-15

    Accurate opacity and equation of state (EOS) data are important parameters for reliable modeling and understanding many phenomena of high energy density physics. However, they are difficult to obtain either theoretically or experimentally especially for high-Z plasmas. In this paper, we proposed a simple method to verify the opacity and EOS of high-Z plasmas in rarefactive states, which is build on the two key aspects of ablation processes, i.e., the propagation of heatwave into materials and the hydrodynamic expansion of the blow-off plasmas. Based on the integrated analysis of the Au foil burnthrough and foam-confined plasma expansion experiments performed on the Shenguang II and Shenguang III prototype laser facilities, we suggested two semi-empirical multipliers to adjust the opacity and EOS of Au plasma. These adjusted opacity and EOS may then provide a foundation for other radiation hydrodynamic simulations under similar drive conditions.

  2. Plasma density enhancements in the high-altitude polar cap region observed on Akebono

    NASA Astrophysics Data System (ADS)

    Ichikawa, Yoh-ichi; Abe, Takumi; Yau, Andrew W.

    2002-05-01

    The plasma density in the polar cap ionosphere is generally low (<103 cm-3 above 3000 km), mainly because of plasma escape from the ionosphere along open magnetic-field lines. The Akebono satellite occasionally encounters regions of unusually high plasma density (>=103 cm-3) above 4000 km altitude, in which the thermal plasma exhibits a distinctively low electron temperature (<3000 K) and low parallel ion drift velocity (<=1 km/s). Such events are almost always observed on the dusk side. The occurrence of low electron temperature and ion drift velocity appears to suggest the antisunward convection of high-density plasma into the polar cap, and the decrease in electron temperature due to the disruption of field-aligned heat flux in the high-altitude polar cap.

  3. Breakdown voltages for discharges initiated from plasma pulses produced by high-frequency excimer lasers

    SciTech Connect

    Yamaura, Michiteru

    2006-06-19

    The triggering ability under the different electric field was investigated using a KrF excimer laser with a high repetition rate of kilohertz order. Measurements were made of the magnitude of impulse voltages that were required to initiate a discharge from plasmas produced by a high-frequency excimer laser. Breakdown voltages were found to be reduced by 50% through the production of plasmas in the discharge gap by a high-frequency excimer laser. However, under direct-current electric field, triggering ability decreased drastically due to low plasma density. It is considered that such laser operation applied for laser-triggered lightning due to the produced location of plasma channel is formed under the impulse electric field since an electric field of the location drastically reduces temporary when the downward leader from thunderclouds propagates to the plasma channel.

  4. Hydrodynamic Simulation of Laser-Driven Generation of Fast High-Density Plasma Blocks

    SciTech Connect

    Glowacz, S.; Badziak, J.; Jablonski, S.; Hora, H.

    2006-01-15

    The laser-induced skin-layer ponderomotive acceleration (S-LPA) is considered to be an efficient method of producing dense plasma blocks of very high ion current densities ({>=}1010A/cm2) and ion beam intensities having the potential to be applied in high energy density physics or for fast ignition of fusion targets. In this contribution properties of plasma blocks generation by S-LPA are studied using a two-fluid relativistic hydrodynamic model of laser-plasma interaction. The main mechanisms, which lead to the generation of high current density ion beams are briefly described and illustrated by numerical calculations performed for the subpicosecond neodymium-glass laser pulses of intensities up to 1019W/cm2 interacting with inhomogeneous hydrogen plasma. The impact of the relativistic effects (e.g. the relativistic change of critical electron density, the appearance of higher harmonics) as well as laser light polarisation on plasma block generation is analysed.

  5. High-temperature coal-syngas plasma characteristics for advanced MHD power generation

    SciTech Connect

    Mikheev, A.V.; Kayukawa, N.; Okinaka, N.; Kamada, Y.; Yatsu, S.

    2006-03-15

    Properties of magnetohydrodynamic (MHD) plasma based on syngas (CO, H{sub 2}) combustion products were investigated experimentally with shock tube facility. The experiments were carried out under various MHD generator load and shock tube operation conditions. Important characteristics of syngas plasma such as temperature, electric field, conductivity, and total output power were directly measured and evaluated. Special attention was paid to the influence of syngas composition (CO : H{sub 2} : O{sub 2} ratio). The results show that syngas combustion can provide high plasma ionization and attainable plasma electrical conductivity has an order of 60-80 S/m at gas temperature 3100-3300 K.

  6. Multi-cm Long High Density Magnetic Plasmas for Optical Guiding

    SciTech Connect

    Pollock, B; Froula, D; Tynan, G; Divol, L; Price, D; Costa, R; Yepiz, F; Fulkerson, S; Mangini, F; Glenzer, S

    2008-05-01

    We present a platform for producing long plasma channels suitable for guiding lasers over several centimeters by applying magnetic fields to limit the radial heat flux from a pre-forming laser beam. The resulting density gradient will be used as an optical plasma waveguide. The plasma conditions have been chosen to be consistent with the requirements for Laser Wakefield Acceleration where multi-GeV electrons are predicted. A detailed description of the system used to produce the high (5 T) magnetic fields and initial results that show a 5 cm long plasma column are discussed.

  7. Ablation of high-Z material dust grains in edge plasmas of magnetic fusion devices

    SciTech Connect

    Marenkov, E. D.; Krasheninnikov, S. I.

    2014-12-15

    The model, including shielding effects of high-Z dust grain ablation in tokamak edge plasma, is presented. In a contrast to shielding models developed for pellets ablation in a hot plasma core, this model deals with the dust grain ablation in relatively cold edge plasma. Using some simplifications, a closed set of equations determining the grain ablation rate Γ is derived and analyzed both analytically and numerically. The scaling law for Γ versus grain radius and ambient plasma parameters is obtained and confirmed by the results of numerical solutions. The results obtained are compared with both dust grain models containing no shielding effects and the pellet ablation models.

  8. Ablation of high-Z material dust grains in edge plasmas of magnetic fusion devices

    NASA Astrophysics Data System (ADS)

    Marenkov, E. D.; Krasheninnikov, S. I.

    2014-12-01

    The model, including shielding effects of high-Z dust grain ablation in tokamak edge plasma, is presented. In a contrast to shielding models developed for pellets ablation in a hot plasma core, this model deals with the dust grain ablation in relatively cold edge plasma. Using some simplifications, a closed set of equations determining the grain ablation rate Γ is derived and analyzed both analytically and numerically. The scaling law for Γ versus grain radius and ambient plasma parameters is obtained and confirmed by the results of numerical solutions. The results obtained are compared with both dust grain models containing no shielding effects and the pellet ablation models.

  9. Milestone report: Status report on high {beta}p experiments at high plasma current

    SciTech Connect

    Casper, T.A.; James, R.A.; Rice, B.W.; Stallard, B.W.

    1995-07-01

    This report summarizes LLNL`s involvement in recent high {beta}{sub p} experiments on the DIII-D tokamak at General Atomics. These experiments were done in collaboration with several members of the DIII-D physics staff from GA and from other collaborating institutions and could not have succeeded without this joint effort. In this report, the authors summary a specific, limited set of experiments to extend high {beta}{sub p} operation with enhanced core confinement to higher plasma currents. The interest in these experiments stems from the non-inductive current drive requirement for steady-state advanced tokamak regimes which can most reasonably be met by operation with a high bootstrap current fraction.

  10. Abnormalities in carbohydrate and lipid metabolisms in high-fructose dietfed insulin-resistant rats: amelioration by Catharanthus roseus treatments.

    PubMed

    Rasineni, Karuna; Bellamkonda, Ramesh; Singareddy, Sreenivasa Reddy; Desireddy, Saralakumari

    2013-09-01

    High intake of dietary fructose has been shown to exert a number of adverse metabolic effects in humans and experimental animals. The present study was proposed to elucidate the effect of Catharanthus roseus (C. roseus) leaf powder treatment on alterations in carbohydrate and lipid metabolisms in rats fed with high-fructose diet. Male Wistar rats of body weight around 180 g were divided into four groups, two of these groups (groups C and C+CR) were fed with standard pellet diet and the other two groups (groups F and F+CR) were fed with high-fructose (66 %) diet. C. roseus leaf powder suspension in water (100 mg/kg body weight/day) was administered orally to group C+CR and group F+CR. At the end of a 60-day experimental period, biochemical parameters related to carbohydrate and lipid metabolisms were assayed. C. roseus treatment completely prevented the fructose-induced increased body weight, hyperglycemia, and hypertriglyceridemia. Hyperinsulinemia and insulin resistance observed in group F was significantly decreased with C. roseus treatment in group F+CR. The alterations observed in the activities of enzymes of carbohydrate and lipid metabolisms and contents of hepatic tissue lipids in group F rats were significantly restored to near normal values by C. roseus treatment in group F+CR. In conclusion, our study demonstrates that C. roseus treatment is effective in preventing fructose-induced insulin resistance and hypertriglyceridemia while attenuating the fructose-induced alterations in carbohydrate and lipid metabolisms. This study suggests that the plant can be used as an adjuvant for the prevention and/or management of insulin resistance and disorders related to it. PMID:23334857

  11. High Resolution Spectral Measurements of Electrical Propulsion Plasmas

    NASA Astrophysics Data System (ADS)

    Celik, Murat; Batishchev, Oleg; Martinez-Sanchez, Manuel

    2007-11-01

    Among various diagnostics methods in studying the EP thrusters' plasma, emission spectroscopy provides a non-invasive, fast and economical diagnostics allowing also the ability to access hard to reach locations. This study presents the spectral measurement results of SPT (BHT-200) and TAL (MHT-9) Hall Effect thrusters and mini-Helicon (mHTX@MIT) thruster plasmas. The measurements were conducted using a 750mm focal length spectrometer with a spectral resolution of up to ˜0.01 nm in the UV-VIS-NIR wavelength range, 200-1000nm. For one set of the measurements, collection optics was placed on a portable optical shelf attached to the window port of the vacuum chamber. For another set of measurements the thruster plasma radiation emission was collected using a collimating lens inside the vacuum chamber and the signal was brought out of the chamber to the spectrometer by the use of UV-rated optical fibers. Accurate spectral characterization was done for Xe and Ar plasma in a broad operational range. Additionally, emission spectroscopy was used to detect line radiation due to wall erosion products in SPT, to study the effect of thruster operational parameters on the ceramic lining erosion rate, subsequently of the thruster's lifetime.

  12. C60-Fullerene Hyper-Velocity High-Density Plasma Jets for MIF and Disruption Mitigation

    NASA Astrophysics Data System (ADS)

    Bogatu, I. N.; Galkin, S. A.; Kim, J. S.

    2009-06-01

    We present an innovative idea to use hyper-velocity (>30 km/s) high-density (>1017 cm-3) plasma jets of D-T/H and C60-fullerene for magneto-inertial fusion (MIF), high energy density laboratory plasma (HEDLP), and disruption mitigation in magnetic fusion plasma devices. The mass (~1-2 g) of sublimated C60 and hydrogen (or D-T fuel) produced in a pulsed power source is ionized and accelerated as a plasma slug in a coaxial plasma accelerator. For MIF/HEDLP we propose to create a magnetized plasma target by injecting two high-Mach number high-density jets with fuel (D-T) and liner (C60/C) structure along the axis of a pulsed magnetic mirror. The magnetized target fusion (MTF) plasma created by head-on collision and stagnation of jets is compressed radially by a metallic liner (Z-pinch) and axially by the C60/C liner. For disruption mitigation, the C60 plasma jets were shown to be able to provide the required impurity mass (J Fusion Energy 27:6, 2008).

  13. RUI: Structure and Behavior of RF-Driven Plasma Filaments in High-Pressure Gases

    SciTech Connect

    Burin, Michael

    2014-11-18

    The filamentary discharge seen within commercial plasma globes is commonly enjoyed, yet not well understood. We investigate filament properties in a plasma globe using a variable high voltage amplifier. Results from the 3-year grant period and their physics are discussed.

  14. Simple Method for Assaying Colistin Methanesulfonate in Plasma and Urine Using High-Performance Liquid Chromatography

    PubMed Central

    Li, Jian; Milne, Robert W.; Nation, Roger L.; Turnidge, John D.; Coulthard, Kingsley; Valentine, Jason

    2002-01-01

    A simple and sensitive high-performance liquid chromatographic method is described for the determination of colistimethate sodium in plasma and urine. The accuracy and reproducibility was within 10.1 and 11.2% with rat plasma and urine, respectively. Several commonly coadministered antibacterial agents do not interfere with the assay. PMID:12234867

  15. Breathing abnormalities in sleep in achondroplasia.

    PubMed Central

    Waters, K A; Everett, F; Sillence, D; Fagan, E; Sullivan, C E

    1993-01-01

    Overnight sleep studies were performed in 20 subjects with achondroplasia to document further the respiratory abnormalities present in this group. Somatosensory evoked potentials (SEPs) were recorded in 19 of the subjects to screen for the presence of brainstem abnormalities, which are one of the potential aetiological mechanisms. Fifteen children aged 1 to 14 years, and five young adults, aged 20 to 31 years were included. All had upper airway obstruction and 15 (75%) had a pathological apnoea index (greater than five per hour). Other sleep associated respiratory abnormalities, including partial obstruction, central apnoea, and abnormal electromyographic activity of accessory muscles of respiration, also showed a high prevalence. SEPs were abnormal in eight (42%), but there was no correlation between abnormal SEPs and apnoea during sleep, either qualitatively or quantitatively. A high prevalence of both sleep related respiratory abnormalities and abnormal SEPs in young subjects with achondroplasia was demonstrated. However, the sleep related respiratory abnormalities do not always result in significant blood gas disturbances or correlate with abnormal SEPs in this group. PMID:8215519

  16. Simulation of ionization effects for high-density positron drivers in future plasma wakefield experiments

    SciTech Connect

    Bruhwiler, D.L.; Dimitrov, D.A.; Cary, J.R.; Esarey, E.; Leemans, W.P.

    2003-05-12

    The plasma wakefield accelerator (PWFA) concept has been proposed as a potential energy doubler for present or future electron-positron colliders. Recent particle-in-cell (PIC) simulations have shown that the self-fields of the required electron beam driver can tunnel ionize neutral Li, leading to plasma wake dynamics differing significantly from that of a preionized plasma. It has also been shown, for the case of a preionized plasma, that the plasma wake of a positron driver differs strongly from that of an electron driver. We will present new PIC simulations, using the OOPIC code, showing the effects of tunneling ionization on the plasma wake generated by high-density positron drivers. The results will be compared to previous work on electron drivers with tunneling ionization and positron drivers without ionization. Parameters relevant to the energy doubler and the upcoming E-164x experiment at the Stanford Linear Accelerator Center will be considered.

  17. Deuterium-tritium TFTR plasmas in the high poloidal beta regime

    SciTech Connect

    Sabbagh, S.A.; Mauel, M.E.; Navratil, G.A.

    1995-03-01

    Deuterium-tritium plasmas with enhanced energy confinement and stability have been produced in the high poloidal beta, advanced tokamak regime in TFTR. Confinement enhancement H {triple_bond} {tau}{sub E}/{tau}{sub E ITER-89P} > 4 has been obtained in a limiter H-mode configuration at moderate plasma current I{sub p} = 0.85 {minus} 1.46 MA. By peaking the plasma current profile, {beta}{sub N dia} {triple_bond} 10{sup 8} < {beta}{sub t{perpendicular}} > aB{sub 0}/I{sub p} = 3 has been obtained in these plasma,s exceeding the {beta}{sub N} limit for TFTR plasmas with lower internal inductance, l{sub i}. Fusion power exceeding 6.7 MW with a fusion power gain Q{sub DT} = 0.22 has been produced with reduced alpha particle first orbit loss provided by the increased l{sub i}.

  18. Surface hardening induced by high flux plasma in tungsten revealed by nano-indentation

    NASA Astrophysics Data System (ADS)

    Terentyev, D.; Bakaeva, A.; Pardoen, T.; Favache, A.; Zhurkin, E. E.

    2016-08-01

    Surface hardness of tungsten after high flux deuterium plasma exposure has been characterized by nanoindentation. The effect of plasma exposure was rationalized on the basis of available theoretical models. Resistance to plastic penetration is enhanced within the 100 nm sub-surface region, attributed to the pinning of geometrically necessary dislocations on nanometric deuterium cavities - signature of plasma-induced defects and deuterium retention. Sub-surface extension of thereby registered plasma-induced damage is in excellent agreement with the results of alternative measurements. The study demonstrates suitability of nano-indentation to probe the impact of deposition of plasma-induced defects in tungsten on near surface plasticity under ITER-relevant plasma exposure conditions.

  19. Determination of human plasma xanthine oxidase activity by high-performance liquid chromatography.

    PubMed

    Yamamoto, T; Moriwaki, Y; Takahashi, S; Tsutsumi, Z; Yamakita, J; Nasako, Y; Hiroishi, K; Higashino, K

    1996-06-01

    An assay for human plasma xanthine oxidase activity was developed with pterin as the substrate and the separation of product (isoxanthopterin) by high-performance liquid chromatography with a fluorescence detector. The reaction mixture consists of 60 microliters of plasma and 240 microliters of 0.2 M Tris-HCl buffer (pH 9.0) containing 113 microM pterin. With this assay, the activity of plasma xanthine oxidase could be easily determined despite its low activity. As a result, it could be demonstrated that the intravenous administration of heparin or the oral administration of ethanol did not increase plasma xanthine oxidase activity in normal subjects, and also that plasma xanthine oxidase activity was higher in patients with hepatitis C virus infection than in healthy subjects or patients with gout. In addition, a single patient with von Gierke's disease showed a marked increase in the plasma activity of this enzyme, relative to that apparent in normal subjects. PMID:8811453

  20. High-frequency electrostatic modes in non-neutral plasmas

    SciTech Connect

    Book, D.L.

    1995-05-01

    A fluid description is employed to derive the dispersion relation for cyclotron modes in a cylindrical non-neutral plasma of radius {ital R} confined by a uniform magnetic field {bold B}={ital B}{sub 0}{bold e}{sub {ital z}} inside a chamber with conducting walls of radius {ital R}{sub 0}. In contrast to the theory of Gould and LaPointe [Phys. Rev. Lett. {bold 67}, 3685 (1991); Phys. Fluids B {bold 4}, 2038 (1992)] the model includes the diamagnetic drift but omits finite Larmor radius effects. The density and the temperature of the unperturbed state are taken to be {ital n}({ital r})={ital n}{sub 0}(1{minus}{ital r}{sup 2}/{ital R}{sup 2}) and {ital T}({ital r})={ital T}{sub 0}(1{minus}{ital r}{sup 2}/{ital R}{sup 2}){sup {gamma}{minus}1}, where {gamma} is the adiabatic index, so that the {ital r}-dependent slow rotation frequency is {omega}{sub {ital r}}{approx}{minus}[{delta}(1{minus}{ital r}{sup 2}/2{ital R}{sup 2})+{epsilon}(1{minus}{ital r}{sup 2}/{ital R}{sup 2}){sup {gamma}{minus}2}]{Omega}/2, where {Omega}={ital qB}{sub 0}/{ital Mc} is the ion gyrofrequency, {delta}=4{pi}{ital n}{sub 0}{ital q}{sup 2}/{ital M}{Omega}{sup 2}, and {epsilon}=4{gamma}{ital T}{sub 0}/{ital M}{Omega}{sup 2}{ital R}{sup 2}. For the linearized fluid equations together with the Poisson equation the eigenvalue problem is solved in the limit {delta}{much_lt}1, {epsilon}{much_lt}1. The eigenfrequencies for high-frequency electrostatic modes with wave vectors satisfying {bold k}{center_dot}{bold B}=0 (Bernstein modes) are found in the form {omega}={minus}{Omega}+{Delta}{omega}, where {Delta}{omega}/{Omega} contains terms proportional to {delta} and {epsilon}. Solutions are obtained and compared with experiment and the theory of Gould and LaPointe. (Abstract Truncated)

  1. [Renal abnormalities in HIV infected patients].

    PubMed

    Pernasetti, María Marta; Chiurchiu, Carlos; Fuente, Jorge de la; Arteaga, Javier de; Douthat, Walter; Bardosy, Cecilia; Zarate, Abel; Massari, Pablo U

    2010-01-01

    Several renal complications may occur during HIV infection, especially in advanced stages related to HIV, to other infectious agents and/or drugs. Little is known about the prevalence of renal diseases that may occur as a complication of or related to HIV infection in asymptomatic patients. This is a single center cross-sectional study of asymptomatic HIV(+) patients referred to a nefrology care service at an Argentine hospital to look for the presence of renal abnormalities. Fifty two consecutive patients were studied between April and November 2008. Patients underwent plasma and urine analysis, ultrasound, and kidney biopsy as needed. Mean age was 39.9 +/- 10.6 years, 88% were male, time from HIV diagnosis 53.2 +/- 41.2 months (2-127); 71% had HIV-disease and 77% were on antiretroviral therapy. Mean plasma HIV-RNA copies number was 7.043 +/- 3.322 and CD4+ cell count: 484 +/- 39. Pathologic findings in urine analysis were present in 30.7% of patients: albuminuria 16.6%, microscopic hematuria 11.5%, hypercalciuria 10.8% and crystalluria 6%. Mean glomerular filtration rate was 102.2 +/- 22.95 ml/min (34-149) and 41% of patients could be classified in stages 1 to 3 of chronic kidney disease. Renal abnormalities prevaled in older patients without relationship with presence of HIV-disease. Two patients were biopsied and the findings included: tubulointerstitial nephritis with presence of crystal deposition in one and IgA nephropathy in the other. No HIV-associated nephropathy was detected. The broad spectrum and the high prevalence of lesions found in this series suggest that asymptomatic HIV-infected patients should routinely undergo renal evaluation. PMID:20529774

  2. Development of High-Throughput Liquid Treatment System using Slot Antenna Excited Microwave Plasma

    NASA Astrophysics Data System (ADS)

    Takitou, Sho; Ito, Michiko; Takashima, Seigou; Nomura, Norio; Kitagawa, Tominori; Toyoda, Hirotaka

    2015-09-01

    Recently, much attention has been given to plasma production under liquid and its industrial applications as well as investigation of chemical reactions as a result of plasma-liquid interactions. In various kinds of plasma production techniques, we have proposed pulsed microwave excited plasma using slot antenna, where damage to the slot electrode can be minimized and plasma volume can be increased. Furthermore, we have proposed an in-line microwave plasma system where plasma is efficiently produced under reduced pressures using Venturi effect, and have demonstrated enhancement of organic decomposition efficiency. For practical use of the plasma liquid treatment, however, cost-effective and more efficient treatment system with high treatment capability is required. In this study, we propose further enhancement of the treatment speed by designing four-parallel-type liquid treatment device where four discharges for the treatment are performed using one microwave power source. Decomposition speed of newly-developed plasma system is investigated. Not only high decomposition rate but also enhanced energy efficiency is realized.

  3. Neuroanatomic and cognitive abnormalities in attention-deficit/hyperactivity disorder in the era of 'high definition' neuroimaging.

    PubMed

    Baroni, Argelinda; Castellanos, F Xavier

    2015-02-01

    The ongoing release of the Human Connectome Project (HCP) data is a watershed event in clinical neuroscience. By attaining a quantum leap in spatial and temporal resolution within the framework of a twin/sibling design, this open science resource provides the basis for delineating brain-behavior relationships across the neuropsychiatric landscape. Here we focus on attention-deficit/hyperactivity disorder (ADHD), which is at least partly continuous across the population, highlighting constructs that have been proposed for ADHD and which are included in the HCP phenotypic battery. We review constructs implicated in ADHD (reward-related processing, inhibition, vigilant attention, reaction time variability, timing and emotional lability) which can be examined in the HCP data and in future 'high definition' clinical datasets. PMID:25212469

  4. Neuroanatomic and Cognitive Abnormalities in Attention-Deficit/Hyperactivity Disorder in the Era of “High Definition” Neuroimaging

    PubMed Central

    Baroni, Argelinda; Castellanos, F. Xavier

    2014-01-01

    The ongoing release of the Human Connectome Project (HCP) data is a watershed event in clinical neuroscience. By attaining a quantum leap in spatial and temporal resolution within the framework of a twin/sibling design, this open science resource provides the basis for delineating brain-behavior relationships across the neuropsychiatric landscape. Here we focus on attention-deficit/hyperactivity disorder (ADHD), which is at least partly continuous across the population, highlighting constructs that have been proposed for ADHD and which are included in the HCP phenotypic battery. We review constructs implicated in ADHD (reward-related processing, inhibition, vigilant attention, reaction time variability, timing and emotional lability) which can be examined in the HCP data and in future “high definition” clinical datasets. PMID:25212469

  5. Abnormally High Content of Free Glucosamine Residues Identified in a Preparation of Commercially Available Porcine Intestinal Heparan Sulfate.

    PubMed

    Mulloy, Barbara; Wu, Nian; Gyapon-Quast, Frederick; Lin, Lei; Zhang, Fuming; Pickering, Matthew C; Linhardt, Robert J; Feizi, Ten; Chai, Wengang

    2016-07-01

    Heparan sulfate (HS) polysaccharides are ubiquitous in animal tissues as components of proteoglycans, and they participate in many important biological processes. HS carbohydrate chains are complex and can contain rare structural components such as N-unsubstituted glucosamine (GlcN). Commercially available HS preparations have been invaluable in many types of research activities. In the course of preparing microarrays to include probes derived from HS oligosaccharides, we found an unusually high content of GlcN residue in a recently purchased batch of porcine intestinal mucosal HS. Composition and sequence analysis by mass spectrometry of the oligosaccharides obtained after heparin lyase III digestion of the polysaccharide indicated two and three GlcN in the tetrasaccharide and hexasaccharide fractions, respectively. (1)H NMR of the intact polysaccharide showed that this unusual batch differed strikingly from other HS preparations obtained from bovine kidney and porcine intestine. The very high content of GlcN (30%) and low content of GlcNAc (4.2%) determined by disaccharide composition analysis indicated that N-deacetylation and/or N-desulfation may have taken place. HS is widely used by the scientific community to investigate HS structures and activities. Great care has to be taken in drawing conclusions from investigations of structural features of HS and specificities of HS interaction with proteins when commercial HS is used without further analysis. Pending the availability of a validated commercial HS reference preparation, our data may be useful to members of the scientific community who have used the present preparation in their studies. PMID:27295282

  6. Abnormally High Content of Free Glucosamine Residues Identified in a Preparation of Commercially Available Porcine Intestinal Heparan Sulfate

    PubMed Central

    2016-01-01

    Heparan sulfate (HS) polysaccharides are ubiquitous in animal tissues as components of proteoglycans, and they participate in many important biological processes. HS carbohydrate chains are complex and can contain rare structural components such as N-unsubstituted glucosamine (GlcN). Commercially available HS preparations have been invaluable in many types of research activities. In the course of preparing microarrays to include probes derived from HS oligosaccharides, we found an unusually high content of GlcN residue in a recently purchased batch of porcine intestinal mucosal HS. Composition and sequence analysis by mass spectrometry of the oligosaccharides obtained after heparin lyase III digestion of the polysaccharide indicated two and three GlcN in the tetrasaccharide and hexasaccharide fractions, respectively. 1H NMR of the intact polysaccharide showed that this unusual batch differed strikingly from other HS preparations obtained from bovine kidney and porcine intestine. The very high content of GlcN (30%) and low content of GlcNAc (4.2%) determined by disaccharide composition analysis indicated that N-deacetylation and/or N-desulfation may have taken place. HS is widely used by the scientific community to investigate HS structures and activities. Great care has to be taken in drawing conclusions from investigations of structural features of HS and specificities of HS interaction with proteins when commercial HS is used without further analysis. Pending the availability of a validated commercial HS reference preparation, our data may be useful to members of the scientific community who have used the present preparation in their studies. PMID:27295282

  7. Construction of a Floating Internal Coil Device for Studying High Beta Plasmas

    NASA Astrophysics Data System (ADS)

    Ogawa, Yuichi; Morikawa, Junji; Ohkuni, Kohtarou; Nihei, Hitoshi; Hori, Dan; Yoshida, Zensho; Mito, Toshiyuki; Yanagi, Nagato; Iwakuma, Narushige

    2001-10-01

    Mahajan-Yoshida has proposed a new relaxation theory, and found a new high-beta plasma configuration with the help of dynamic pressure induced by a strong plasma flow. For exploring this new relaxed configuration, the internal coil device is suitable. Now we are constructing the internal coil device with a floating super-conductor for studying high beta plasmas; the major radius of the internal coil is 15 cm and the coil current is 50 kA, and planning to produce a high density neutral plasma with 2.45 GHz Electron Cyclotron Heating system. The strong plasma flow in toroidal direction is expected by producing non-neutral plasmas. We have adopted to use high temperature superconductor (HTS) tape for the floating coil, expecting easy and reliable operation and maintenance of a super-conducting coil. In addition, the HTS coil is preferable for plasma experiments, because long pulse and/or high power heating experiments might be available due to the high thermal stability property and large heat capacity of the HTS coil. We have fabricated a small HTS coil and succeeded to levitate it with an accuracy of a few tens micrometers.

  8. The lipoprotein abnormality in Tangier disease: quantitation of A apoproteins.

    PubMed Central

    Assmann, G; Smootz, E; Adler, K; Capurso, A; Oette, K

    1977-01-01

    In this study we have determined by radioimmunoassay and double immunoelectrophoresis the total quantities and distributions of A apoproteins in three adult patients affected with Tangier disease (hereditary alpha-lipoprotein deficiency). Compared with normal plasma, the total quantities of apoproteins A-I and A-II in Tangier plasma were determined to be less than 1% and 5-7%, respectively. In Tangier patients, approximately 90% of the apoprotein A-I sedimented when ultracentrifugations of plasma were carried out at density 1.21 g/ml KBr. By contrast, more than 95% of the apoprotein A-II floated under those conditions. In normal plasma, approximately 90% of both apoproteins A-I and A-II is found in the 1.063-1.21-g/ml KBr density fraction. These findings suggest that complete dissociation of A apoproteins occurs in Tangier plasma. This dissociation of apoproteins was confirmed by double immunoelectrophoresis with monospecific antisera. Immunochemical and electrophoretic experiments did not provide evidence for a structural abnormality of apoprotein A-I in these patients, The results taken together strongly suggest that normal high-density lipoproteins are absent from Tangier plasma. Images PMID:190272

  9. Brain abnormalities in high-risk violent offenders and their association with psychopathic traits and criminal recidivism.

    PubMed

    Leutgeb, V; Leitner, M; Wabnegger, A; Klug, D; Scharmüller, W; Zussner, T; Schienle, A

    2015-11-12

    Measures of psychopathy have been proved to be valuable for risk assessment in violent criminals. However, the neuronal basis of psychopathy and its contribution to the prediction of criminal recidivism is still poorly understood. We compared structural imaging data from 40 male high-risk violent offenders and 37 non-delinquent healthy controls via voxel-based morphometry. Psychopathic traits and risk of violence recidivism were correlated with gray matter volume (GMV) of regions of interest previously shown relevant for criminal behavior. Relative to controls, criminals showed less GMV in the prefrontal cortex (PFC) and more GMV in cerebellar regions and basal ganglia structures. Within criminals, we found a negative correlation between prefrontal GMV and psychopathy. Additionally, there was a positive correlation between cerebellar GMV and psychopathy as well as risk of recidivism for violence. Moreover, GMVs of the basal ganglia and supplementary motor area (SMA) were positively correlated with anti-sociality. GMV of the amygdala was negatively correlated with dynamic risk for violence recidivism. In contrast, GMV of (para)limbic areas (orbitofrontal cortex, insula) was positively correlated with anti-sociality and risk of violence recidivism. The current investigation revealed that in violent offenders deviations in GMV of the PFC as well as areas involved in the motor component of impulse control (cerebellum, basal ganglia, SMA) are differentially related to psychopathic traits and the risk of violence recidivism. The results might be valuable for improving existing risk assessment tools. PMID:26362887

  10. Production and study of high-beta plasma confined by a superconducting dipole magnet

    SciTech Connect

    Garnier, D.T.; Hansen, A.; Mauel, M.E.; Ortiz, E.; Boxer, A.C.; Ellsworth, J.; Karim, I.; Kesner, J.; Mahar, S.; Roach, A.

    2006-05-15

    The Levitated Dipole Experiment (LDX) [J. Kesner et al., in Fusion Energy 1998, 1165 (1999)] is a new research facility that is exploring the confinement and stability of plasma created within the dipole field produced by a strong superconducting magnet. Unlike other configurations in which stability depends on curvature and magnetic shear, magnetohydrodynamic stability of a dipole derives from plasma compressibility. Theoretically, the dipole magnetic geometry can stabilize a centrally peaked plasma pressure that exceeds the local magnetic pressure ({beta}>1), and the absence of magnetic shear allows particle and energy confinement to decouple. In initial experiments, long-pulse, quasi-steady-state microwave discharges lasting more than 10 s have been produced that are consistent with equilibria having peak beta values of 20%. Detailed measurements have been made of discharge evolution, plasma dynamics and instability, and the roles of gas fueling, microwave power deposition profiles, and plasma boundary shape. In these initial experiments, the high-field superconducting floating coil was supported by three thin supports. The plasma is created by multifrequency electron cyclotron resonance heating at 2.45 and 6.4 GHz, and a population of energetic electrons, with mean energies above 50 keV, dominates the plasma pressure. Creation of high-pressure, high-beta plasma is possible only when intense hot electron interchange instabilities are stabilized by sufficiently high background plasma density. A dramatic transition from a low-density, low-beta regime to a more quiescent, high-beta regime is observed when the plasma fueling rate and confinement time become sufficiently large.

  11. High-order harmonic generation by nonlinear reflection of an intense high-contrast laser pulse on a plasma.

    PubMed

    Monot, Pascal; Doumy, Gilles; Dobosz, Sundrine; Perdrix, Michel; D'Oliveira, Pascal; Quéré, Fabion; Réau, Fabrice; Martin, Philippe; Audebert, Patrick; Gauthier, Jean-Claude; Geindre, Jean-Paul

    2004-04-15

    We demonstrate the use of a plasma mirror to obtain 60-fs 10-TW laser pulses with a temporal contrast of 10(8) on a nanosecond time scale and 10(6) on a picosecond time scale, and we use these high-contrast pulses to generate high harmonics by nonlinear reflection on a plasma with a steep electronic density gradient. Well-collimated harmonics up to 20th order are observed for a laser intensity of approximately equal to 3 x 10(17) W/cm2, whereas no harmonics are obtained without the plasma mirror. PMID:15119413

  12. Applying X-ray Imaging Crystal Spectroscopy for Use as a High Temperature Plasma Diagnostic.

    PubMed

    Cao, Norman M; Mier Valdivia, Andrés M; Rice, John E

    2016-01-01

    X-ray spectra provide a wealth of information on high temperature plasmas; for example electron temperature and density can be inferred from line intensity ratios. By using a Johann spectrometer viewing the plasma, it is possible to construct profiles of plasma parameters such as density, temperature, and velocity with good spatial and time resolution. However, benchmarking atomic code modeling of X-ray spectra obtained from well-diagnosed laboratory plasmas is important to justify use of such spectra to determine plasma parameters when other independent diagnostics are not available. This manuscript presents the operation of the High Resolution X-ray Crystal Imaging Spectrometer with Spatial Resolution (HIREXSR), a high wavelength resolution spatially imaging X-ray spectrometer used to view hydrogen- and helium-like ions of medium atomic number elements in a tokamak plasma. In addition, this manuscript covers a laser blow-off system that can introduce such ions to the plasma with precise timing to allow for perturbative studies of transport in the plasma. PMID:27585305

  13. Abnormalities in myo-inositol metabolism associated with type 2 diabetes in mice fed a high-fat diet: benefits of a dietary myo-inositol supplementation.

    PubMed

    Croze, Marine L; Géloën, Alain; Soulage, Christophe O

    2015-06-28

    We previously reported that a chronic supplementation with myo-inositol (MI) improved insulin sensitivity and reduced fat accretion in mice. We then tested the potency of such dietary intervention in the prevention of insulin resistance in C57BL/6 male mouse fed a high-fat diet (HFD). In addition, some abnormalities in inositol metabolism were reported to be associated with insulin resistance in several animal and human studies. We then investigated the presence of such anomalies (i.e. inosituria and an inositol intra-tissue depletion) in this diet-induced obesity (DIO) mouse model, as well as the potential benefit of a MI supplementation for inositol intra-tissue deficiency correction. HFD (60 % energy from fat) feeding was associated with inosituria and inositol intra-tissue depletion in the liver and kidneys. MI supplementation (0·58 mg/g per d) restored inositol pools in kidneys (partially) and liver (fully). HFD feeding for 4 months induced ectopic lipid redistribution to liver and muscles, fasting hyperglycaemia and hyperinsulinaemia, insulin resistance and obesity that were not prevented by MI supplementation, despite a significant improvement in insulin sensitivity parameter K insulin tolerance test and a reduction in white adipose tissue (WAT) mass ( - 17 %, P< 0·05). MI supplementation significantly reduced fatty acid synthase activity in epididymal WAT, which might explain its beneficial, but modest, effect on WAT accretion in HFD-fed mice. Finally, we found some abnormalities in inositol metabolism in association with a diabetic phenotype (i.e. insulin resistance and fasting hyperglycaemia) in a DIO mouse model. Dietary MI supplementation was efficient in the prevention of inositol intra-tissue depletion, but did not prevent insulin resistance or obesity efficiently in this mouse model. PMID:25990651

  14. Production of high-density capacitively coupled radio-frequency discharge plasma by high-secondary-electron-emission oxide

    SciTech Connect

    Ohtsu, Yasunori; Fujita, Hiroharu

    2004-11-22

    High-density capacitively coupled radio-frequency plasma with electron density n{sub e}>10{sup 10} cm{sup -3} was produced using MgO electrodes with a high secondary-electron-emission coefficient. It was found that in the case of MgO electrodes, both plasma density and optical emission intensity were about one order of magnitude higher than those in the case of Al electrodes.

  15. Structurally abnormal human autosomes

    SciTech Connect

    1993-12-31

    Chapter 25, discusses structurally abnormal human autosomes. This discussion includes: structurally abnormal chromosomes, chromosomal polymorphisms, pericentric inversions, paracentric inversions, deletions or partial monosomies, cri du chat (cat cry) syndrome, ring chromosomes, insertions, duplication or pure partial trisomy and mosaicism. 71 refs., 8 figs.

  16. Free boundary, high beta equilibrium in a large aspect ratio tokamak with nearly circular plasma boundary

    SciTech Connect

    Qin, H.; Reiman, A.

    1996-09-25

    An analytic solution is obtained for free-boundary, high-beta equilibria in large aspect ratio tokamaks with a nearly circular plasma boundary. In the absence of surface currents at the plasma-vacuum interface, the free-boundary equilibrium solution introduces constraints arising from the need to couple to an external vacuum field which is physically realizable with a reasonable set of external field coils. This places a strong constraint on the pressure profiles that are consistent with a given boundary shape at high {epsilon}{beta}{sub p}. The equilibrium solution also provides information on the flux surface topology. The plasma is bounded by a separatrix. Increasing the plasma pressure at fixed total current causes the plasma aperture to decrease in a manner that is described.

  17. X-ray emission from high temperature plasmas

    NASA Technical Reports Server (NTRS)

    Harries, W. L.

    1974-01-01

    X-rays from a 25-hJ plasma focus apparatus were observed with pinhole cameras. The cameras consist of 0.4 mm diameter pinholes in 2 cm thick lead housing enclosing an X-ray intensifying screen at the image plane. Pictures recorded through thin aluminum foils or plastic sheets for X-ray energies sub gamma smaller than 15 keV show distributed X-ray emissions from the focussed plasma and from the anode surface. However, when thick absorbers are used, radial filamentary structure in the X-ray emission from the anode surface is revealed. Occasionally larger structures are observed in addition to the filaments. Possible mechanisms for the filamentary structure are discussed.

  18. A high-charge-state plasma neutralizer for an energetic H/sup -/ beam

    SciTech Connect

    Schlachter, A.S.; Leung, K.N.; Stearns, J.W.; Olson, R.E.

    1986-10-01

    A high-charge-state plasma neutralizer for a beam of energetic H/sup -/ ions offers the potential of high optimum neutralization efficiency (approx.85%) relative to a gas target (50 to 60%), and considerably reduced target thickness. We have calculated cross sections for charge-changing interactions of fast H/sup -/ and H/sup 0/ in collision with highly charged ions using a semiclassical model for H/sup -/, and the Classical-Trajectory Monte Carlo method plus Born calculations, to obtain correct asymptotic cross sections in the high-energy limit. Charge-state fractions as a function of plasma line density, and f/sub 0//sup max/, the maximum H/sup 0/ fraction, are calculated using these cross sections; we find that f/sub 0//sup mx/ approx. = 85% for ion charge states in the range 1+ to 10+, and that target ion line density for f/sub 0//sup max/ decreases approximately as the square of the plasma ion charge state. The maximum neutral fraction is also high for a partially ionized plasma. We have built a small multicusp plasma generator to use a a plasma neutralizer; preliminary results show that the plasma contains argon ions with an average charge state between 2+ and 3+ for a steady-state discharge.

  19. High average power, highly brilliant laser-produced plasma source for soft X-ray spectroscopy

    SciTech Connect

    Mantouvalou, Ioanna; Grötzsch, Daniel; Neitzel, Michael; Günther, Sabrina; Baumann, Jonas; Kanngießer, Birgit; Witte, Katharina; Jung, Robert; Stiel, Holger; Sandner, Wolfgang

    2015-03-15

    In this work, a novel laser-produced plasma source is presented which delivers pulsed broadband soft X-radiation in the range between 100 and 1200 eV. The source was designed in view of long operating hours, high stability, and cost effectiveness. It relies on a rotating and translating metal target and achieves high stability through an on-line monitoring device using a four quadrant extreme ultraviolet diode in a pinhole camera arrangement. The source can be operated with three different laser pulse durations and various target materials and is equipped with two beamlines for simultaneous experiments. Characterization measurements are presented with special emphasis on the source position and emission stability of the source. As a first application, a near edge X-ray absorption fine structure measurement on a thin polyimide foil shows the potential of the source for soft X-ray spectroscopy.

  20. Modeling of neutral gas dynamics in high-density plasmas

    NASA Astrophysics Data System (ADS)

    Canupp, Patrick Wellington

    This thesis describes a physical model of chemically reactive neutral gas flow and discusses numerical solutions of this model for the flow in an inductively coupled plasma etch reactor. To obtain these solutions, this research develops an efficient, implicit numerical method. As a result of the enhanced numerical stability of the scheme, large time steps advance the solution from initial conditions to a final steady state in fewer iterations and with less computational expense than simpler explicit methods. This method would incorporate suitably as a module in currently existing large scale plasma simulation tools. In order to demonstrate the accuracy of the numerical technique, this thesis presents results from two simulations of flows that possess theoretical solutions. The first case is the inviscid flow of a gas through a converging nozzle. A comparison of the numerical solution to isentropic flow theory shows that the numerical technique capably captures the essential flow features of this environment. The second case is the Couette flow of a gas between two parallel plates. The simulation results compare well with the exact solution for this flow. After establishing the accuracy of the numerical technique, this thesis discusses results for the flow of chemically reactive gases in a chlorine plasma etch reactor. This research examines the influence of the plasma on the neutral gas and the dynamics exhibited by the neutral gas in the reactor. This research finds that the neutral gas temperature strongly depends on the rate at which inelastic, electron-impact dissociation reactions occur and on atomic chlorine wall recombination rates. Additionally, the neutral gas Aow in the reactor includes a significant mass flux of etch product from the wafer surface. Resolution of these effects is useful for neutral gas simulation. Finally, this thesis demonstrates that continuum fluid models provide reasonable accuracy for these low pressure reactor flows due to the fact

  1. Storm time plasma transport at middle and high latitudes

    SciTech Connect

    Foster, J.C. )

    1993-02-01

    Associated with the large-scale enhancement of the ionospheric convection electric field during disturbed geomagnetic conditions, solar-produced F region plasma is transported to and through the noontime cleft from a source region at middle and low latitudes in the afternoon sector. As a result of the offset between the geomagnetic and geographic poles, the afternoon sector region of strong sunward convection is shifted to increasingly lower geographic latitude throughout the interval between 12 UT and 24 UT. A snowplow effect occurs in which the convection cell continually encounters fresh corotating ionospheric plasma along its equatorward edge, producing a latitudinally narrow region of storm-enhanced plasma density (SED) and increased total electron content which is advected toward higher latitudes in the noon sector. The Millstone Hill incoherent scatter radar regularly observes SED as a spatially continuous, large-scale feature spanning local times between noon and midnight and at latitudes between the polar cap and its mid- or low-latitude source region. For local times away from noon, the latitude of most probable SED occurrence moves equatorward by 6[degrees] for an increase of 2 in the Kp index. During strong disturbances the topside SED is observed to be convecting sunward at [approximately]750 m s[sup [minus]1] with a flux of 10[sup 14] m[sup [minus]2] s[sup [minus]1]. This feature accounts for the pronounced enhancement of ionospheric density near dusk at middle latitudes observed during the early stages of magnetic storms (called the dusk effect) and constitutes a source for the enhanced F region plasma observed in the polar cap during disturbed conditions. 34 refs., 13 figs., 1 tab.

  2. High Magnetic field generation for laser-plasma experiments

    SciTech Connect

    Pollock, B B; Froula, D H; Davis, P F; Ross, J S; Fulkerson, S; Bower, J; Satariano, J; Price, D; Glenzer, S H

    2006-05-01

    An electromagnetic solenoid was developed to study the effect of magnetic fields on electron thermal transport in laser plasmas. The solenoid, which is driven by a pulsed power system suppling 30 kJ, achieves magnetic fields of 13 T. The field strength was measured on the solenoid axis with a magnetic probe and optical Zeeman splitting. The measurements agree well with analytical estimates. A method for optimizing the solenoid design to achieve magnetic fields exceeding 20 T is presented.

  3. Atmospheric Pressure Plasma: A High-Performance Tool for the Efficient Removal of Biofilms

    PubMed Central

    Fricke, Katja; Koban, Ina; Tresp, Helena; Jablonowski, Lukasz; Schröder, Karsten; Kramer, Axel; Weltmann, Klaus-Dieter; von Woedtke, Thomas; Kocher, Thomas

    2012-01-01

    Introduction The medical use of non-thermal physical plasmas is intensively investigated for sterilization and surface modification of biomedical materials. A further promising application is the removal or etching of organic substances, e.g., biofilms, from surfaces, because remnants of biofilms after conventional cleaning procedures are capable to entertain inflammatory processes in the adjacent tissues. In general, contamination of surfaces by micro-organisms is a major source of problems in health care. Especially biofilms are the most common type of microbial growth in the human body and therefore, the complete removal of pathogens is mandatory for the prevention of inflammatory infiltrate. Physical plasmas offer a huge potential to inactivate micro-organisms and to remove organic materials through plasma-generated highly reactive agents. Method In this study a Candida albicans biofilm, formed on polystyrene (PS) wafers, as a prototypic biofilm was used to verify the etching capability of the atmospheric pressure plasma jet operating with two different process gases (argon and argon/oxygen mixture). The capability of plasma-assisted biofilm removal was assessed by microscopic imaging. Results The Candida albicans biofilm, with a thickness of 10 to 20 µm, was removed within 300 s plasma treatment when oxygen was added to the argon gas discharge, whereas argon plasma alone was practically not sufficient in biofilm removal. The impact of plasma etching on biofilms is localized due to the limited presence of reactive plasma species validated by optical emission spectroscopy. PMID:22880025

  4. Multiple Magnetic Storm Study of the High-Altitude Redistribution of Equatorial Plasma

    NASA Astrophysics Data System (ADS)

    Bust, G. S.; Crowley, G.; Curtis, N.; Anderson, D.

    2008-12-01

    During geomagnetic storms, particularly when prompt penetration electric fields (PPE) occur, the equatorial plasma can be lifted to very high altitudes and then diffuse along magnetic field lines to higher than normal latitudes. During these cases very high plasma density (total electron content (TEC) greater than 200 TECU) can be found at these higher latitudes. Shortly after the PPE lifts the equatorial plasma to higher altitudes, at least in the US sector, phenomena known as storm-enhanced density (SED) can occur. SEDs occur in the post-noon time frame and consist of a very high density bulge that seems to occur in the southern USA and Caribbean region, followed by a narrow plume of high density plasma that flows into the high-latitude throat near local noon, and across the polar cap. An outstanding research question is: Exactly how is the high density SED plasma, particularly in the bulge related to the PPE and lifting of the equatorial plasma? Ionospheric imaging of electron density and TEC seem to show a gap in density between the poleward extent of the equatorial plasma and the equatorial extent of the SED plasma. Further, there are magnetic storm events where SEDs do not form (November 2004 as a good example). This paper will investigate the relationship between the equatorial high altitude plasma distribution during magnetic storms, and the initiation and evolution of the SED feature. We will examine eight separate storms from 2003-2006 using the ionospheric data assimilation algorithm IDA4D. In particular we will focus on time periods when LEO satellite GPS TEC data is available from CHAMP, SACC, GRACE and the COSMIC constellation (2006 and beyond). These data sets directly measure the TEC above the satellites, and therefore are good tracers of the high altitude plasma distribution. IDA4D ingests these data sets and uses them to get an improved image of the plasma density for the topside ionosphere and plasmasphere. The resulting 4D images of high

  5. Production of high-density capacitive plasma by the effects of multihollow cathode discharge and high-secondary-electron emission

    SciTech Connect

    Ohtsu, Y.; Fujita, H.

    2008-04-28

    High-density capacitively coupled plasma with electron density of 10{sup 11} cm{sup -3} was produced with the effects of the multihollow cathode discharge and the high-secondary-electron emission from radio frequency (rf)-biased electrode using Ar gas. It was found that the optimum pressure was around 3-15 Pa. In the case of only multihollow cathode discharge, the plasma density increased from 1.2x10{sup 10} to 8x10{sup 10} cm{sup -3} with the increasing distance z from the cathode electrode for 5 mmplasma density increased with increasing voltage of rf-biased electrode. The rate of deposited amorphous hydrocarbon thin films of about 200 nm/min was attained with the high-density rf plasma enhanced chemical vapor deposition using CH{sub 4} gas.

  6. Experiment and simulation of novel liquid crystal plasma mirrors for high contrast, intense laser pulses

    PubMed Central

    Poole, P. L.; Krygier, A.; Cochran, G. E.; Foster, P. S.; Scott, G. G.; Wilson, L. A.; Bailey, J.; Bourgeois, N.; Hernandez-Gomez, C.; Neely, D.; Rajeev, P. P.; Freeman, R. R.; Schumacher, D. W.

    2016-01-01

    We describe the first demonstration of plasma mirrors made using freely suspended, ultra-thin films formed dynamically and in-situ. We also present novel particle-in-cell simulations that for the first time incorporate multiphoton ionization and dielectric models that are necessary for describing plasma mirrors. Dielectric plasma mirrors are a crucial component for high intensity laser applications such as ion acceleration and solid target high harmonic generation because they greatly improve pulse contrast. We use the liquid crystal 8CB and introduce an innovative dynamic film formation device that can tune the film thickness so that it acts as its own antireflection coating. Films can be formed at a prolonged, high repetition rate without the need for subsequent realignment. High intensity reflectance above 75% and low-field reflectance below 0.2% are demonstrated, as well as initial ion acceleration experimental results that demonstrate increased ion energy and yield on shots cleaned with these plasma mirrors. PMID:27557592

  7. Experiment and simulation of novel liquid crystal plasma mirrors for high contrast, intense laser pulses.

    PubMed

    Poole, P L; Krygier, A; Cochran, G E; Foster, P S; Scott, G G; Wilson, L A; Bailey, J; Bourgeois, N; Hernandez-Gomez, C; Neely, D; Rajeev, P P; Freeman, R R; Schumacher, D W

    2016-01-01

    We describe the first demonstration of plasma mirrors made using freely suspended, ultra-thin films formed dynamically and in-situ. We also present novel particle-in-cell simulations that for the first time incorporate multiphoton ionization and dielectric models that are necessary for describing plasma mirrors. Dielectric plasma mirrors are a crucial component for high intensity laser applications such as ion acceleration and solid target high harmonic generation because they greatly improve pulse contrast. We use the liquid crystal 8CB and introduce an innovative dynamic film formation device that can tune the film thickness so that it acts as its own antireflection coating. Films can be formed at a prolonged, high repetition rate without the need for subsequent realignment. High intensity reflectance above 75% and low-field reflectance below 0.2% are demonstrated, as well as initial ion acceleration experimental results that demonstrate increased ion energy and yield on shots cleaned with these plasma mirrors. PMID:27557592

  8. Particle-In-Cell simulations of high pressure plasmas using graphics processing units

    NASA Astrophysics Data System (ADS)

    Gebhardt, Markus; Atteln, Frank; Brinkmann, Ralf Peter; Mussenbrock, Thomas; Mertmann, Philipp; Awakowicz, Peter

    2009-10-01

    Particle-In-Cell (PIC) simulations are widely used to understand the fundamental phenomena in low-temperature plasmas. Particularly plasmas at very low gas pressures are studied using PIC methods. The inherent drawback of these methods is that they are very time consuming -- certain stability conditions has to be satisfied. This holds even more for the PIC simulation of high pressure plasmas due to the very high collision rates. The simulations take up to very much time to run on standard computers and require the help of computer clusters or super computers. Recent advances in the field of graphics processing units (GPUs) provides every personal computer with a highly parallel multi processor architecture for very little money. This architecture is freely programmable and can be used to implement a wide class of problems. In this paper we present the concepts of a fully parallel PIC simulation of high pressure plasmas using the benefits of GPU programming.

  9. Magnetowave Induced Plasma Wakefield Acceleration for Ultra High Energy Cosmic Rays

    SciTech Connect

    Chang, Feng-Yin; Chen, Pisin; Lin, Guey-Lin; Noble, Robert; Sydora, Richard; /Alberta U.

    2009-10-17

    Magnetowave induced plasma wakefield acceleration (MPWA) in a relativistic astrophysical outflow has been proposed as a viable mechanism for the acceleration of cosmic particles to ultrahigh energies. Here we present simulation results that clearly demonstrate the viability of this mechanism for the first time. We invoke the high frequency and high speed whistler mode for the driving pulse. The plasma wakefield obtained in the simulations compares favorably with our newly developed relativistic theory of the MPWA. We show that, under appropriate conditions, the plasma wakefield maintains very high coherence and can sustain high-gradient acceleration over hundreds of plasma skin depths. Invoking active galactic nuclei as the site, we show that MPWA production of ultrahigh energy cosmic rays beyond ZeV (10{sup 21} eV) is possible.

  10. Thermal plasma process for recovering monomers and high value carbons from polymeric materials

    DOEpatents

    Knight, Richard; Grossmann, Elihu D.; Guddeti, Ravikishan R.

    2002-01-01

    The present invention relates to a method of recycling polymeric waste products into monomers and high value forms of carbon by pyrolytic conversion using an induction coupled RF plasma heated reactor.

  11. Langmuir probe diagnostics of plasma in high current electron cyclotron resonance proton ion source

    SciTech Connect

    Roychowdhury, P.; Kewlani, H.; Mishra, L.; Mittal, K. C.; Patil, D. S.

    2013-07-15

    A high current Electron Cyclotron Resonance (ECR) proton ion source has been developed for low energy high intensity proton accelerator at Bhabha Atomic Research Centre. Langmuir probe diagnostics of the plasma generated in this proton ion source is performed using Langmuir probe. The diagnostics of plasma in the ion source is important as it determines beam parameters of the ion source, i.e., beam current, emittance, and available species. The plasma parameter measurement in the ion source is performed in continuously working and pulsed mode using hydrogen as plasma generation gas. The measurement is performed in the ECR zone for operating pressure and microwave power range of 10{sup −4}–10{sup −3} mbar and 400–1000 W. An automated Langmuir probe diagnostics unit with data acquisition system is developed to measure these parameters. The diagnostics studies indicate that the plasma density and plasma electron temperature measured are in the range 5.6 × 10{sup 10} cm{sup −3} to 3.8 × 10{sup 11} cm{sup −3} and 4–14 eV, respectively. Using this plasma, ion beam current of tens of mA is extracted. The variations of plasma parameters with microwave power, gas pressure, and radial location of the probe have been studied.

  12. Method for minimizing decarburization and other high temperature oxygen reactions in a plasma sprayed material

    DOEpatents

    Lenling, William J.; Henfling, Joseph A.; Smith, Mark F.

    1993-06-08

    A method is disclosed for spray coating material which employs a plasma gun that has a cathode, an anode, an arc gas inlet, a first powder injection port, and a second powder injection port. A suitable arc gas is introduced through the arc gas inlet, and ionization of the arc gas between the cathode and the anode forms a plasma. The plasma is directed to emenate from an open-ended chamber defined by the boundary of the anode. A coating is deposited upon a base metal part by suspending a binder powder within a carrier gas that is fed into the plasma through the first powder injection port; a material subject to degradation by high temperature oxygen reactions is suspended within a carrier gas that is fed into the plasma through the second injection port. The material fed through the second injection port experiences a cooler portion of the plasma and has a shorter dwell time within the plasma to minimize high temperature oxygen reactions. The material of the first port and the material of the second port intermingle within the plasma to form a uniform coating having constituent percentages related to the powder-feed rates of the materials through the respective ports.

  13. Preliminary investigation of high power microwave plasmas for electrothermal thruster use

    NASA Technical Reports Server (NTRS)

    Power, John L.; Sullivan, Daniel J.

    1993-01-01

    Results are reported from preliminary tests to evaluate the high power microwave electrothermal thruster (MET) concept, which employs a free-floating plasma discharge maintained by applied CW microwave power to heat a propellant gas flow. Stable plasmas have been created and maintained in helium (He), nitrogen (N2), and hydrogen (H2) as propellants in both the TM(sub 011) and TM(sub 012) modes at discharge pressures from 10 Pa to 69 kPa. Reproducible starting conditions of pressure and power have been documented for all the plasmas. Vortical inflow of the propellant gas was observed to cause the formation of on-axis 'spike' plasmas. The formation and unformation conditions of these plasmas were studied. Operation in the spike plasma condition enables maximum power absorption with minimum wall heating and offers maximum efficiency in heating the propellant gas. In the spike condition, plasmas of the three propellant gases were investigated in an open channel configuration to a maximum applied power level of 11.2 kW (in N2). Microwave power coupling efficiencies of over 90 percent were routinely obtained at absorbed power levels up to 2 kW. Magnetic nozzle effects were investigated with a superconducting solenoid Al magnet applying a high magnetic field to the plasmas in and exiting from the discharge tube.

  14. Self-induced gaseous plasma as high power microwave opening switch medium

    SciTech Connect

    Lin, S.; Beeson, S.; Dickens, J.; Neuber, A.; Liu, C.

    2015-04-15

    Self-induced gaseous plasma is evaluated as active opening switch medium for pulsed high power microwave radiation. The self-induced plasma switch is investigated for N{sub 2} and Ar environments under pressure conditions ranging from 25 to 700 Torr. A multi-pass TE{sub 111} resonator is used to significantly reduce the delay time inherently associated with plasma generation. The plasma forms under the pulsed excitation of a 4 MW magnetron inside the central dielectric tube of the resonator, which isolates the inner atmospheric gas from the outer vacuum environment. The path from the power source to the load is designed such that the pulse passes through the plasma twice with a 35 ns delay between these two passes. In the first pass, initial plasma density is generated, while the second affects the transition to a highly reflective state with as much as 30 dB attenuation. Experimental data revealed that virtually zero delay time may be achieved for N{sub 2} at 25 Torr. A two-dimensional fluid model was developed to study the plasma formation times for comparison with experimental data. The delay time predicted from this model agrees well with the experimental values in the lower pressure regime (error < 25%), however, due to filamentary plasma formation at higher pressures, simulated delay times may be underestimated by as much as 50%.

  15. Thermal and Nonthermal Electron-ion Bremsstrahlung Spectrum from High-Temperature Plasmas

    NASA Technical Reports Server (NTRS)

    Jung, Young-Dae

    1994-01-01

    Electron-ion bremsstrahlung radiation from high-temperature plasmas is investigated. The first- and second-order Coulomb corrections in the nonrelativistic bremsstrahlung radiation power are obtained by the Elwert-Sommerfeld factor. In this paper, two cases of the electron distributions, the thermal and nonthermal power-law distributions, are considered. The inclusion of Coulomb corrections is necessary in deducing correctly the electron distribution function from radiation data. These results provide the correct information of electron distributions in high-temperature plasmas, such as in inertial confinement fusion plasmas and in the astrophysical hot thermal and nonthermal x-ray sources.

  16. Theory of interparticle correlations in dense, high-temperature plasmas. V - Electric and thermal conductivities

    NASA Technical Reports Server (NTRS)

    Ichimaru, S.; Tanaka, S.

    1985-01-01

    Ichimaru et al. (1985) have developed a general theory in which the interparticle correlations in dense, high-temperature multicomponent plasmas were formulated systematically over a wide range of plasma parameters. The present paper is concerned with an extension of this theory, taking into account the problems of the electronic transport in such high-density plasmas. It is shown that the resulting theory is capable of describing the transport coefficients accurately over a wide range of the density and temperature parameters. Attention is given to electric and thermal conductivities, generalized Coulomb logarithms, a comparison of the considered theory with other theories, and a comparison of the theory with experimental results.

  17. Fabrication of spatial transient-density structures as high-field plasma photonic devices

    SciTech Connect

    Pai, C.-H.; Huang, S.-Y.; Kuo, C.-C.; Lin, M.-W.; Wang, J.; Chen, S.-Y.; Lee, C.-H.; Lin, J.-Y.

    2005-07-15

    Fabrication of periodic transient-density structures in a gas jet with a boundary scale length approaching 10 {mu}m was demonstrated. This was achieved by passing an ultrashort high-intensity laser pulse through a patterned mask and imaging the mask onto the target plane. Gas/plasma density at the laser-irradiated regions drops as a result of hydrodynamic expansion following ionization and heating by the laser pulse. The fabrication of gas/plasma density structures with such a scheme is an essential step in the development of plasma photonic devices for applications in high-field physics.

  18. Method for generating a highly reactive plasma for exhaust gas aftertreatment and enhanced catalyst reactivity

    DOEpatents

    Whealton, John H.; Hanson, Gregory R.; Storey, John M.; Raridon, Richard J.; Armfield, Jeffrey S.; Bigelow, Timothy S.; Graves, Ronald L.

    2002-01-01

    A method for non-thermal plasma aftertreatment of exhaust gases the method comprising the steps of providing short risetime, high frequency, high power bursts of low-duty factor microwaves sufficient to generate a plasma discharge and passing a gas to be treated through the discharge so as to cause dissociative reduction of the exhaust gases and enhanced catalyst reactivity through application of the pulsed microwave fields directly to the catalyst material sufficient to cause a polarizability catastrophe and enhanced heating of the metal crystallite particles of the catalyst, and in the presence or absence of the plasma. The invention also includes a reactor for aftertreatment of exhaust gases.

  19. Characteristics of the soft X-ray emission from laser-produced highly charged platinum plasmas

    NASA Astrophysics Data System (ADS)

    Hara, Hiroyuki; Arai, Goki; Kondo, Yoshiki; Dinh, Thanh-Hung; Dunne, Padraig; O’Sullivan, Gerry; Ejima, Takeo; Hatano, Tadashi; Jiang, Weihua; Nishikino, Masaharu; Sasaki, Akira; Sunahara, Atsushi; Higashiguchi, Takeshi

    2016-06-01

    We characterized the spectral structure of the soft X-ray emission and determined the plasma parameters in laser-produced highly charged platinum plasmas. The spectral structure observed originated from Pt21+ to Pt34+ ions, emissions from which overlapped to produce a high output flux in the carbon-window soft X-ray spectral region. Using dual laser pulse irradiation, we observed the maximum output flux, which was 20% larger than that obtained under single-laser irradiation, and the evolution of a strongly absorbed spectral structure, which was attributed to the effects of both opacity and long-scale length of the expanding pre-plasma.

  20. Evaluation of plasma pressure of high current low inductance vacuum spark on cathode surface

    NASA Astrophysics Data System (ADS)

    Sarantsev, S. A.

    2016-01-01

    This paper presents evaluation of the plasma pressure in a high current, low inductance vacuum spark on the cathode surface (the electrode material is steel). Calculations are provided for the first half period of the discharge, wherein the cathode surface is subjected to the most severe impacts (micropinches are created resulting in high-energy plasma beams). The evaluations were made using the experimental data obtained on the Pion device. The data of electrical measurements of the discharge current, the average plasma flow values obtained with the multi-grid probe and the data from a cathode macrostructure study were used. The results are given for different values of the discharge current.

  1. The effect of chronic erythrocytic polycythemia and high altitude upon plasma and blood volumes.

    NASA Technical Reports Server (NTRS)

    Burton, R. R.; Smith, A. H.

    1972-01-01

    Comparison of two kinds of physiological chronic erythrocytic polycythemias in order to differentiate the specific effect of erythrocytic polycythemia from the general effects of high altitude upon the plasma volume. The two kinds were produced hormonally in female chickens, at sea level, or by protracted high-altitude exposures. It appears that the vascular system of the body may account for an increase in red blood cell mass either by reduction in plasma volume, or by no change in plasma volume, resulting in differential changes in total blood volumes.

  2. High rep rate high performance plasma focus as a powerful radiation source

    SciTech Connect

    Lee, S.; Lee, P.; Zhang, G.; Feng, X.; Liu, M.; Serban, A.; Wong, T.K.S.; Gribkov, V.A.

    1998-08-01

    Basic operational characteristics of the plasma focus are considered from design perspectives to develop powerful radiation sources. Using these ideas the authors have developed two compact plasma focus (CPF) devices operating in neon with high performance and high repetition rate capacity for use as an intense soft X-ray (SXR) source for microelectronics lithography. The NX1 is a four-module system with a peak current of 320 kA when the capacitor bank (7.8 {micro}F {times} 4) is charged to 14 kV. It produces 100 J of SXR per shot (4% wall plug efficiency) giving at 3 Hz, 300 W of average SXR power into 4{pi}. The NX2 is also a four-module system. Each module uses a rail gap switching 12 capacitors each with a capacity of 0.6 {micro}F. The NX2 operates with peak currents of 400 kA at 11.5 kV into water-cooled electrodes at repetition rates up to 16 Hz to produce 300 W SXR in burst durations of several minutes. SXR lithographs are taken from both machines to demonstrate that sufficient SXR lithographs are taken from both machines to demonstrate that sufficient SXR flux is generated for an exposure with only 300 shots. In addition, flash electron lithographs are also obtained requiring only ten shots per exposure. Such high performance compact machines may be improved to yield over 1 kW of SXR, enabling sufficient exposure throughput to be of interest to the wafer industry. In deuterium the neutron yield could be over 10{sup 10} neutrons per second over prolonged bursts of minutes.

  3. Method for generating a highly reactive plasma for exhaust gas aftertreatment and enhanced catalyst reactivity

    DOEpatents

    Whealton, John H.; Hanson, Gregory R.; Storey, John M.; Raridon, Richard J.; Armfield, Jeffrey S.; Bigelow, Timothy S.; Graves, Ronald L.

    2001-01-01

    A method for non-thermal plasma aftertreatment of exhaust gases the method comprising the steps of providing short risetime (about 40 ps), high frequency (about 5G hz), high power bursts of low-duty factor microwaves sufficient to generate a dielectric barrier discharge and passing a gas to treated through the discharge so as to cause dissociative reduction of the exhaust gases. The invention also includes a reactor for generating the non-thermal plasma.

  4. Effects of high voltage nanosecond pulsed plasma and micro DBD plasma on seed germination, growth development and physiological activities in spinach.

    PubMed

    Ji, Sang-Hye; Choi, Ki-Hong; Pengkit, Anchalee; Im, Jun Sup; Kim, Ju Sung; Kim, Yong Hee; Park, Yeunsoo; Hong, Eun Jeong; Jung, Sun Kyung; Choi, Eun-Ha; Park, Gyungsoon

    2016-09-01

    In this study, we analyzed seed germination, seedling growth, and physiological aspects after treatment with high voltage nanosecond pulsed plasma and micro DBD plasma in spinach (Spinacia oleracea L.), a green leafy vegetable known to have low germination rate. Both germination and dry weight of seedlings increased after high voltage pulse shots were applied to spinach seeds. However seeds treated with many shots (10 shots) showed a decrease in germination rate and seedling growth. Seeds treated with air DBD plasma exhibited slightly higher germination and subsequent seedling growth than those treated with N2 plasma. Seed surface was degenerated after treated with high voltage pulsed plasma and micro DBD plasma but no significant difference in the degree of degeneration was observed among micro DBD plasma treatment time. Level of GA3 hormone and mRNA expression of an amylolytic enzyme-related gene in seeds were elevated 1 day after treatment with high voltage pulsed plasma. The relative amount of chlorophyll and total polyphenols in spinach seedlings grown from seeds treated with air DBD plasma was increased in 30 s, 1 min, and 3 min treatments. Taken together, our results suggest a possibility that plasma can enhance seed germination by triggering biochemical processes in seeds. PMID:26944552

  5. Transport and fluctuations in high temperature spheromak plasmas

    NASA Astrophysics Data System (ADS)

    McLean, Harry

    2005-10-01

    A systematic analysis is presented of thermal transport in a driven spheromak that extends well into the collisionless regime and spans a wide range of magnetic fluctuation levels. The relationship between internal fluctuations and energy/helicity transport is of fundamental interest to many self-organized configurations in laboratory and space plasmas and the subject of ongoing multi-institutional collaborations. With the recent achievement on the SSPX spheromak[1] of electron temperature Te˜350eV in the core, and good confinement (core electron thermal diffusivity χe<10m^2/ for Te>200eV), we are now comparing heat transport in the experiment with a variety of models including classical, Bohm, and stochastic[2]/diffusive[3]/open[4] field lines. Using Thomson scattering to measure Te, ne profiles and the CORSICA equilibrium code to calculate internal current profiles from magnetic probe fits, we find that χe decreases as Te increases, a scaling behavior more classical-like than Bohm or open field line models would indicate. Lower Te and higher χe is observed in the transition region between the core and the separatrix where NIMROD 3d resistive MHD calculations[5] show the possible existence of chaotic field lines. We will also discuss plans including multi-pulse Thomson scattering and neutral beam heating. [1] E.B. Hooper, et al., Nucl. Fusion 39, 863 (1999). [2] A.B. Rechester and M.N. Rosenbluth, Phys. Rev. Lett. 40, 38 (1978). [3] J.D. Callen, Phys. Rev. Lett. 94, 055002 (2005). [4] R.W. Moses, et al., Phys. Plasmas 8, 4839 (2001). [5] B.I. Cohen, et al., Phys. Plasmas 12, 056106 (2005). This work was performed under the auspices of the U.S. Department of Energy by the University of California Lawrence Livermore National Laboratory under Contract No. W-7405-Eng-48.

  6. High Current Systems for HyperV and PLX Plasma Railguns

    NASA Astrophysics Data System (ADS)

    Brockington, S.; Case, A.; Messer, S.; Elton, R.; Witherspoon, F. D.

    2011-10-01

    HyperV is developing gas fed, pulsed, plasma railgun accelerators for PLX and other high momentum plasma applications. The present 2.5 cm square-bore plasma railgun forms plasma armatures from high density neutral gas (argon), preionizes it electrothermally, and accelerates the armature with 30 cm long parallel-plate railgun electrodes driven by a pulse forming network (PFN). Recent experiments have successfully formed and accelerated plasma armatures of ~4 mg at 40 km/s, with PFN currents of ~400 kA. In order to further increase railgun performance to the PLX design goal of 8 mg at 50 km/s, the PFN was upgraded to support currents of up to ~750 kA. A high voltage, high current linear array spark-gap switch and flexible, low-inductance transmission line were designed and constructed to handle the increased current load. We will describe these systems and present initial performance data from high current operation of the plasma rail gun from spectroscopy, interferometry, and imaging systems as well as pressure, magnetic field, and optical diagnostics. High current performance of railgun bore materials for electrodes and insulators will also be discussed as well as plans for upcoming experimentation with advanced materials. Supported by the U.S. DOE Joint Program in HEDLP.

  7. Mass analyzer ``MASHA'' high temperature target and plasma ion source

    NASA Astrophysics Data System (ADS)

    Semchenkov, A. G.; Rassadov, D. N.; Bekhterev, V. V.; Bystrov, V. A.; Chizov, A. Yu.; Dmitriev, S. N.; Efremov, A. A.; Guljaev, A. V.; Kozulin, E. M.; Oganessian, Yu. Ts.; Starodub, G. Ya.; Voskresensky, V. M.; Bogomolov, S. L.; Paschenko, S. V.; Zelenak, A.; Tikhonov, V. I.

    2004-05-01

    A new separator and mass analyzer of super heavy atoms (MASHA) has been created at the FLNR JINR Dubna to separate and measure masses of nuclei and molecules with precision better than 10-3. First experiments with the FEBIAD plasma ion source have been done and give an efficiency of ionization of up to 20% for Kr with a low flow test leak (6 particle μA). We suppose a magnetic field optimization, using the additional electrode (einzel lens type) in the extracting system, and an improving of the vacuum conditions in order to increase the ion source efficiency.

  8. Furosemide Pharmacokinetics in Adult Rats become Abnormal with an Adverse Intrauterine Environment and Modulated by a Post-Weaning High-Fat Diet.

    PubMed

    DuBois, Barent N; Pearson, Jacob; Mahmood, Tahir; Thornburg, Kent; Cherala, Ganesh

    2016-06-01

    Adult individuals born with intrauterine growth restriction (IUGR) have physiological maladaptations that significantly increase risk of chronic disease. We suggested that such abnormalities in organ function would alter pharmacokinetics throughout life, exacerbated by environmental mismatch. Pregnant and lactating rats were fed either a purified control diet (18% protein) or low-protein diet (9% protein) to produce IUGR offspring. Offspring were weaned onto either laboratory chow (11% fat) or high-fat diet (45% fat). Adult offspring (5 months old) were dosed with furosemide (10 mg/kg i.p.) and serum and urine collected. The overall exposure profile in IUGR males was significantly reduced due to a ~35% increase in both clearance and volume of distribution. Females appeared resistant to the IUGR phenotype. The effects of the high-fat diet trended in the opposite direction to that of IUGR, with increased drug exposure due to decreases in both clearance (31% males, 46% females) and volume of distribution (24% males, 44% females), with a 10% longer half-life in both genders. The alterations in furosemide pharmacokinetics and pharmacodynamics were explained by changes in the expression of renal organic anion transporters 1 and 3, and sodium-potassium-chloride cotransporter-2. In summary, this study suggests that IUGR and diet interact to produce subpopulations with similar body-weights but dissimilar pharmacokinetic profiles; this underlines the limitation of one-size-fits-all dosing which does not account for physiological differences in body composition resulting from IUGR and diet. PMID:26550796

  9. High growth rate homoepitaxial diamond film deposition at high temperatures by microwave plasma-assisted chemical vapor deposition

    NASA Technical Reports Server (NTRS)

    Vohra, Yogesh K. (Inventor); McCauley, Thomas S. (Inventor)

    1997-01-01

    The deposition of high quality diamond films at high linear growth rates and substrate temperatures for microwave-plasma chemical vapor deposition is disclosed. The linear growth rate achieved for this process is generally greater than 50 .mu.m/hr for high quality films, as compared to rates of less than 5 .mu.m/hr generally reported for MPCVD processes.

  10. Plasma torch for ignition, flameholding and enhancement of combustion in high speed flows

    NASA Technical Reports Server (NTRS)

    O'Brien, Walter F. (Inventor); Billingsley, Matthew C. (Inventor); Sanders, Darius D. (Inventor); Schetz, Joseph A. (Inventor)

    2009-01-01

    Preheating of fuel and injection into a plasma torch plume fro adjacent the plasma torch plume provides for only ignition with reduced delay but improved fuel-air mixing and fuel atomization as well as combustion reaction enhancement. Heat exchange also reduced erosion of the anode of the plasma torch. Fuel mixing atomization, fuel mixture distribution enhancement and combustion reaction enhancement are improved by unsteady plasma torch energization, integral formation of the heat exchanger, fuel injection nozzle and plasma torch anode in a more compact, low-profile arrangement which is not intrusive on a highspeed air flow with which the invention is particularly effective and further enhanced by use of nitrogen as a feedstock material and inclusion of high pressure gases in the fuel to cause effervescence during injection.

  11. High frequency atmospheric cold plasma treatment system for materials surface processing

    NASA Astrophysics Data System (ADS)

    Tudoran, Cristian D.; Surducan, Vasile; Anghel, Sorin D.

    2012-02-01

    The paper presents a new laboratory-made plasma treatment system. The power source which generates the plasma is based on a modern half-bridge type inverter circuit working at a frequency of 4 MHz, and giving an output power of about 200 W. The inverter is fed directly from the mains voltage and features high speed protection circuits for both over voltage and over current protection, making the system light and easy to operate. The output of the inverter is connected to the resonant circuit formed by a Tesla coil and the dielectric barrier discharge plasma chamber. The plasma is generated at atmospheric pressure in argon, helium or mixtures of helium and small quantities of argon. It is a cold discharge (Tgas < 150°C) with a homogeneous structure. The plasma generates chemically active species, especially O and OH, which could be important in various applications such as the treatment and processing of materials surfaces.

  12. Generation of neutral and high-density electron–positron pair plasmas in the laboratory

    PubMed Central

    Sarri, G.; Poder, K.; Cole, J. M.; Schumaker, W.; Di Piazza, A.; Reville, B.; Dzelzainis, T.; Doria, D.; Gizzi, L. A.; Grittani, G.; Kar, S.; Keitel, C. H.; Krushelnick, K.; Kuschel, S.; Mangles, S. P. D.; Najmudin, Z.; Shukla, N.; Silva, L. O.; Symes, D.; Thomas, A. G. R.; Vargas, M.; Vieira, J.; Zepf, M.

    2015-01-01

    Electron–positron pair plasmas represent a unique state of matter, whereby there exists an intrinsic and complete symmetry between negatively charged (matter) and positively charged (antimatter) particles. These plasmas play a fundamental role in the dynamics of ultra-massive astrophysical objects and are believed to be associated with the emission of ultra-bright gamma-ray bursts. Despite extensive theoretical modelling, our knowledge of this state of matter is still speculative, owing to the extreme difficulty in recreating neutral matter–antimatter plasmas in the laboratory. Here we show that, by using a compact laser-driven setup, ion-free electron–positron plasmas with unique characteristics can be produced. Their charge neutrality (same amount of matter and antimatter), high-density and small divergence finally open up the possibility of studying electron–positron plasmas in controlled laboratory experiments. PMID:25903920

  13. Three dimensional space charge model for large high voltage satellites. [plasma sheath

    NASA Technical Reports Server (NTRS)

    Cooks, D.; Parker, L. W.; Mccoy, J. E.

    1980-01-01

    High power solar arrays for satellite power systems with dimensions of kilometers, and with tens of kilovolts distributed over their surface face many plasma interaction problems that must be properly anticipated. In most cases, the effects cannot be adequately modeled without detailed knowledge of the plasma sheath structure and space charge effects. Two computer programs were developed to provide fully self consistent plasma sheath models in three dimensions as a result of efforts to model the experimental plasma sheath studies at NASA/JSC. Preliminary results indicate that for the conditions considered, the Child-Langmuir diode theory can provide a useful estimate of the plasma sheath thickness. The limitations of this conclusion are discussed. Some of the models presented exhibit the strong ion focusing observed in the JSC experiments.

  14. Generation of neutral and high-density electron-positron pair plasmas in the laboratory.

    PubMed

    Sarri, G; Poder, K; Cole, J M; Schumaker, W; Di Piazza, A; Reville, B; Dzelzainis, T; Doria, D; Gizzi, L A; Grittani, G; Kar, S; Keitel, C H; Krushelnick, K; Kuschel, S; Mangles, S P D; Najmudin, Z; Shukla, N; Silva, L O; Symes, D; Thomas, A G R; Vargas, M; Vieira, J; Zepf, M

    2015-01-01

    Electron-positron pair plasmas represent a unique state of matter, whereby there exists an intrinsic and complete symmetry between negatively charged (matter) and positively charged (antimatter) particles. These plasmas play a fundamental role in the dynamics of ultra-massive astrophysical objects and are believed to be associated with the emission of ultra-bright gamma-ray bursts. Despite extensive theoretical modelling, our knowledge of this state of matter is still speculative, owing to the extreme difficulty in recreating neutral matter-antimatter plasmas in the laboratory. Here we show that, by using a compact laser-driven setup, ion-free electron-positron plasmas with unique characteristics can be produced. Their charge neutrality (same amount of matter and antimatter), high-density and small divergence finally open up the possibility of studying electron-positron plasmas in controlled laboratory experiments. PMID:25903920

  15. A simple, high performance Thomson scattering diagnostic for high temperature plasma research

    SciTech Connect

    Hartog, D.J.D.; Cekic, M.

    1994-02-01

    This Thomson scattering diagnostic is used to measure the electron temperature and density of the plasma in the MST reversed-field pinch, a magnetic confinement fusion research device. This diagnostic system is unique for its type in that it combines high performance with simple design and low cost components. In the design of this instrument, careful attention was given to the suppression of stray laser line light with simple and effective beam dumps, viewing dumps, aperatures, and a holographic edge filter. This allows the use of a single grating monochromator for dispersion of the Thomson scattered spectrum onto the microchannel plate detector. Alignment and calibration procedures for the laser beam delivery system, the scattered light collection system, and the spectrometer and detector are described. A sample Thomson scattered spectrum illustrates typical data.

  16. High Resolution Transmission Grating Spectrometer for Edge Toroidal Rotation Measurements of Tokamak Plasmas

    SciTech Connect

    Graf, A; May, M; Beiersdorfer, P; Magee, E; Lawrence, M; Terry, J; Rice, J

    2004-04-29

    We present a high throughput (f/3) visible (3500 - 7000 Angstrom) Doppler spectrometer for toroidal rotation velocity measurements of the Alcator C-Mod tokamak plasma. The spectrometer has a temporal response of 1 ms and a rotation velocity sensitivity of {approx}10{sup 5} cm/s. This diagnostic will have a tangential view and map out the plasma rotation at several locations along the outer half of the minor radius (r/a > 0.5). The plasma rotation will be determined from the Doppler shifted wavelengths of D{sub alpha} and magnetic and electric dipole transitions of highly ionized impurities in the plasma. The fast time resolution and high spectral resolving power are possible due to a 6' diameter circular transmission grating that is capable of {lambda}/{Delta}{lambda} {approx} 15500 at 5769 Angstrom in conjunction with a 50 {micro}m slit.

  17. Production of high quality syngas from argon/water plasma gasification of biomass and waste.

    PubMed

    Hlina, M; Hrabovsky, M; Kavka, T; Konrad, M

    2014-01-01

    Extremely hot thermal plasma was used for the gasification of biomass (spruce sawdust, wood pellets) and waste (waste plastics, pyrolysis oil). The plasma was produced by a plasma torch with DC electric arc using unique hybrid stabilization. The torch input power of 100-110 kW and the mass flow rate of the gasified materials of tens kg/h was set up during experiments. Produced synthetic gas featured very high content of hydrogen and carbon monoxide (together approximately 90%) that is in a good agreement with theory. High quality of the produced gas is given by extreme parameters of used plasma--composition, very high temperature and low mass flow rate. PMID:24148259

  18. Confinement physics for thermal, neutral, high-charge-state plasmas in nested-well solenoidal traps.

    PubMed

    Dolliver, D D; Ordonez, C A

    1999-06-01

    A theoretical study is presented which indicates that it is possible to confine a neutral plasma using static electric and solenoidal magnetic fields. The plasma consists of equal temperature electrons and highly stripped ions. The solenoidal magnetic field provides radial confinement, while the electric field, which produces an axial nested-well potential profile, provides axial confinement. A self-consistent, multidimensional numerical solution for the electric potential is obtained, and a fully kinetic theoretical treatment on axial transport is used to determine an axial confinement time scale. The effect on confinement of the presence of a radial electric field is explored with the use of ion trajectory calculations. A thermal, neutral, high-charge-state plasma confined in a nested-well trap opens new possibilities for fundamental studies on plasma recombination and cross-field transport processes under highly controlled conditions. PMID:11969700

  19. High voltage plasma sheath analysis related to TSS-1

    NASA Technical Reports Server (NTRS)

    Sheldon, John W.

    1990-01-01

    On the first mission of the Tethered Satellite System (TSS-1), a 1.8 m diameter spherical satellite will be deployed a distance of 20 km above the Space Shuttle Orbiter on an insulated conducting tether. The satellite will be held at electric potentials up to 5000 volts positive with respect to the ambient plasma. Due to the passage of the conducting tether through the Earth's magnetic field, an electromagnetic field (EMF) will be created, driving electrons down the tether to the Orbiter, out through an electron gun into the ionosphere and back into the positive-biased satellite. The main problem addressed here is the current-voltage characteristics of the ionospheric interaction with the satellite. The first problem is that while the satellite will be capable of measuring charged particle flow to the surface at several locations, the detectors have a limited range of acceptance angle. The second problem is that the angle of incidence of the incoming electrons will have to be relative to the local normal. This will be important in order to predict the magnitude of the detectable current at each detector location so the detector gain can be pre-set to the correct range. The plasma sheath was analyzed mathematically, and subroutines were written to solve relevant finite element, Taylor-Vlasov, and Poisson equations.

  20. Liquid lithium divertor characteristics and plasma-material interactions in NSTX high-performance plasmas

    NASA Astrophysics Data System (ADS)

    Jaworski, M. A.; Abrams, T.; Allain, J. P.; Bell, M. G.; Bell, R. E.; Diallo, A.; Gray, T. K.; Gerhardt, S. P.; Kaita, R.; Kugel, H. W.; LeBlanc, B. P.; Maingi, R.; McLean, A. G.; Menard, J.; Nygren, R.; Ono, M.; Podesta, M.; Roquemore, A. L.; Sabbagh, S. A.; Scotti, F.; Skinner, C. H.; Soukhanovskii, V. A.; Stotler, D. P.; the NSTX Team

    2013-08-01

    Liquid metal plasma-facing components (PFCs) have been proposed as a means of solving several problems facing the creation of economically viable fusion power reactors. To date, few demonstrations exist of this approach in a diverted tokamak and we here provide an overview of such work on the National Spherical Torus Experiment (NSTX). The Liquid Lithium Divertor (LLD) was installed and operated for the 2010 run campaign using evaporated coatings as the filling method. The LLD consisted of a copper-backed structure with a porous molybdenum front face. Nominal Li filling levels by the end of the run campaign exceeded the porosity void fraction by 150%. Despite a nominal liquid level exceeding the capillary structure and peak current densities into the PFCs exceeding 100 kA m-2, no macroscopic ejection events were observed. In addition, no substrate line emission was observed after achieving lithium-melt temperatures indicating the lithium wicks and provides a protective coating on the molybdenum porous layer. Impurity emission from the divertor suggests that the plasma is interacting with oxygen-contaminated lithium whether diverted on the LLD or not. A database of LLD discharges is analysed to consider whether there is a net effect on the discharges over the range of total deposited lithium in the machine. Examination of H-97L indicates that performance was constant throughout the run, consistent with the hypothesis that it is the quality of the surface layers of the lithium that impact performance. The accumulation of impurities suggests a fully flowing liquid lithium system to obtain a steady-state PFC on timescales relevant to NSTX.