Science.gov

Sample records for abrupt restrictive diverter

  1. Factor V Leiden, Prothrombin and MTHFR Mutation in Patients with Preeclamsia, Intrauterine Growth Restriction and Placental Abruption

    PubMed Central

    Livrinova, Vesna; Lega, Marija Hadzi; Dimcheva, Anita Hristova; Samardziski, Igor; Isjanovska, Rozalinda

    2015-01-01

    BACKGROUND: Factor V Leiden, Prothrombin and MTHFR gene mutation, could have an influence in pregnancy with adverse outcome Preeclamsia, IUGR and Placental abruption. AIM: The aim of this study is to investigate the presence of above mentioned inherited thrombophilias and its statistical significance, distribution among the complicated and normal pregnancy, and relative risk for carrier of mutation to develop preeclampsia, IUGR and placental abruption. MATERIAL AND METHODS: Prospective cohort study is implemented at University Clinic for Obstetric and Gynecology in Skopje, Republic of Macedonia. The study included 109 delivered patients: 40 with preeclapmsia, 22 with IUGR, 17 with placental abruption and 30 as control group with normal pregnancy. The amount of 3 ml venous blood has been used for detection of these point mutations using ThromboStrip -Opegen, QIAGEN kit manufactured for thrombotic risk. RESULTS: The highest frequency was found: in the group with preeclampsia 35% were MTHFR homozygous, IUGR -MTHFR heterozygous 45%, Placental abruption- 52.9% MTHFR heterozygous, and in the control group without thrombophilia 56.7%. There were combined thrombophilia in 3 patients. There aren`t statistical significance in presence of thrombophilia among groups (p > 0.05). Statistical significance (p < 0.05) was found between carriers of MTHFR homozygous in preeclampsia and group with placental abruption and control group. Relative risk in IUGR group for MTHFR homozygous was 5.54 (1.37abruption for Factor V Leiden heterozygous was 4.50 (0.47abruption. Further investigations with more patients are warranted. PMID:27275292

  2. Cygnus Diverter Switch Analysis

    SciTech Connect

    G. Corrow, M. Hansen, D. Henderson, C. Mitton et al.

    2008-02-01

    The Cygnus Dual Beam Radiographic Facility consists of two 2.25-MV, 60-kA, 50-ns x-ray sources fielded in an underground laboratory at the Nevada Test Site. The tests performed in this laboratory involve study of the dynamic properties of plutonium and are called subcritical experiments. From end-to-end, the Cygnus machines utilize the following components: Marx generator, water-filled pulse-forming line (PFL), waterfilled coaxial transmission line (WTL), 3-cell inductive voltage adder (IVA), and rod-pinch diode. The upstream WTL interface to the PFL is via a radial insulator with coaxial geometry. The downstream WTL terminates in a manifold where the center conductor splits into three lines which individually connect to each of the IVA cell inputs. There is an impedance mismatch at this juncture. It is a concern that a reflected pulse due to anomalous behavior in the IVA or diode might initiate breakdown upon arrival at the upstream PFL/WTL insulator. Therefore near the beginning of the WTL a radial diverter switch is installed to protect the insulator from over voltage and breakdown. The diverter has adjustable gap spacing, and an in-line aqueous-solution (sodium thiosulfate) resistor array for energy dissipation. There are capacitive voltage probes at both ends of the WTL and on the diverter switch. These voltage signals will be analyzed to determine diverter performance. Using this analysis the usefulness of the diverter switch will be evaluated.

  3. Diverter assembly for radioactive material

    DOEpatents

    Andrews, Katherine M.; Starenchak, Robert W.

    1989-01-01

    A diverter assembly for diverting a pneumatically conveyed holder for a radioactive material between a central conveying tube and one of a plurality of radially offset conveying tubes includes an airtight container. A diverter tube having an offset end is suitably mounted in the container for rotation. A rotary seal seals one end of the diverter tube during and after rotation of the diverter tube while a spring biased seal seals the other end of the diverter tube which mvoes between various offset conveying tubes. An indexing device rotatably indexes the diverter tube and this indexing device is driven by a suitable drive. The indexing mechanism is preferably a geneva-type mechanism to provide a locking of the diverter tube in place.

  4. Diverter assembly for radioactive material

    DOEpatents

    Andrews, K.M.; Starenchak, R.W.

    1988-04-11

    A diverter assembly for diverting a pneumatically conveyed holder for a radioactive material between a central conveying tube and one of a plurality of radially offset conveying tubes includes an airtight container. A diverter tube having an offset end is suitably mounted in the container for rotation. A rotary seal seals one end of the diverter tube during and after rotation of the diverter tube while a spring biased seal seals the other end of the diverter tube which moves between various offset conveying tubes. An indexing device rotatably indexes the diverter tube and this indexing device is driven by a suitable drive. The indexing mechanism is preferably a geneva-type mechanism to provide a locking of the diverter tube in place. 3 figs.

  5. Air diverter for supercharger

    SciTech Connect

    Johnson, K.A.

    1986-10-28

    An engine supercharger is described which consists of a turbine housing, a main turbine wheel of the radial-inflow type located within the turbine housing, a compressor housing having an air entrance passageway, and a compressor wheel of the centrifugal type located within the compressor housing. It also includes a main shaft of annular construction interconnecting the turbine wheel and the compressor wheel whereby the two wheels rotate as a unit, an auxiliary turbine wheel of the axial flow type located downstream from the main turbine wheel, and a fan of the axial flow type located upstream from the compressor wheel. An auxiliary shaft extends within the main shaft between the auxiliary turbine and fan whereby the auxiliary turbine and fan rotate as a unit. An annular air collector chamber means is located immediately downstream from the fan in surrounding relation to the aforementioned entrance passageway for diverting some of the fan air from the compressor wheel. The fan comprises a hub and blades radiating outwardly therefrom. The air collector chamber is defined in part by an annular wall having a free edge located within the fan blade axial profile whereby the annular wall intercepts air discharged from outer tip areas of the fan blades to divert same away from the compressor wheel into the collector chamber.

  6. Annular flow diverter valve

    DOEpatents

    Rider, Robert L.

    1980-01-01

    A valve for diverting flow from the center of two concentric tubes to the annulus between the tubes or, operating in the reverse direction, for mixing fluids from concentric tubes into a common tube and for controlling the volume ratio of said flow consists of a toroidal baffle disposed in sliding engagement with the interior of the inner tube downstream of a plurality of ports in the inner tube, a plurality of gates in sliding engagement with the interior of the inner tube attached to the baffle for movement therewith, a servomotor having a bullet-shaped plug on the downstream end thereof, and drive rods connecting the servomotor to the toroidal baffle, the servomotor thereby being adapted to move the baffle into mating engagement with the bullet-shaped plug and simultaneously move the gates away from the ports in the inner tube and to move the baffle away from the bullet-shaped plug and simultaneously move the gates to cover the ports in the inner tube.

  7. Flow Diverters for Intracranial Aneurysms

    PubMed Central

    Alderazi, Yazan J.; Kass-Hout, Tareq; Prestigiacomo, Charles J.; Gandhi, Chirag D.

    2014-01-01

    Flow diverters (pipeline embolization device, Silk flow diverter, and Surpass flow diverter) have been developed to treat intracranial aneurysms. These endovascular devices are placed within the parent artery rather than the aneurysm sac. They take advantage of altering hemodynamics at the aneurysm/parent vessel interface, resulting in gradual thrombosis of the aneurysm occurring over time. Subsequent inflammatory response, healing, and endothelial growth shrink the aneurysm and reconstruct the parent artery lumen while preserving perforators and side branches in most cases. Flow diverters have already allowed treatment of previously untreatable wide neck and giant aneurysms. There are risks with flow diverters including in-stent thrombosis, perianeurysmal edema, distant and delayed hemorrhages, and perforator occlusions. Comparative efficacy and safety against other therapies are being studied in ongoing trials. Antiplatelet therapy is mandatory with flow diverters, which has highlighted the need for better evidence for monitoring and tailoring antiplatelet therapy. In this paper we review the devices, their uses, associated complications, evidence base, and ongoing studies. PMID:24967131

  8. Can ice sheets trigger abrupt climatic change?

    SciTech Connect

    Hughes, T.

    1996-11-01

    The discovery in recent years of abrupt climatic changes in climate proxy records from Greenland ice cores and North Atlantic sediment cores, and from other sites around the world, has diverted attention from gradual insolation changes caused by Earth`s orbital variations to more rapid processes on Earth`s surface as forcing Quaternary climatic change. In particular, forcing by ice sheets has been quantified for a major ice stream that drained the Laurentide Ice Sheet along Hudson Strait. The history of these recent discoveries leading to an interest in ice sheets is reviewed, and a case is made that ice sheets may drive abrupt climatic change that is virtually synchronous worldwide. Attention is focused on abrupt inception and termination of a Quaternary glaciation cycle, abrupt changes recorded as stadials and interstadials within the cycle, abrupt changes in ice streams that trigger stadials and interstadials, and abrupt changes in the Laurentide Ice Sheet linked to effectively simultaneous abrupt changes in its ice streams. Remaining work needed to quantify further these changes is discussed. 90 refs., 14 figs.

  9. Bistable diverter valve in microfluidics

    NASA Astrophysics Data System (ADS)

    Tesař, V.; Bandalusena, H. C. H.

    2011-05-01

    Bistable diverter valves are useful for a large number of no-moving-part flow control applications, and there is a considerable interest in using them also in microfluidics, especially for handling small pressure-driven flows. However, with decreasing Reynolds number, the Coanda effect—on which the flow diverting effect depends—becomes less effective. Authors performed a study, involving flow visualisation, PIV experiments, measurements of the flow rates, and numerical flowfield computations, aimed at clarifying behaviour of a typical fluidic valve at low Reynolds numbers. A typical fluidic valve originally developed for high Re operation was demonstrated to be useful, though with progressively limited efficiency, down to surprisingly low Re values as small as Re = 800. Also observed was a previously not reported discontinuation in the otherwise monotonic decrease in performance at Re between 1,500 and 2,000.

  10. Magnetic Heat Pump Containing Flow Diverters

    NASA Technical Reports Server (NTRS)

    Howard, Frank S.

    1995-01-01

    Proposed magnetic heat pump contains flow diverters for suppression of undesired flows. If left unchecked, undesired flows mix substantial amounts of partially heated and partially cooled portions of working fluid, effectively causing leakage of heat from heated side to cooled side. By reducing leakage of heat, flow diverters increase energy efficiency of magnetic heat pump, potentially offering efficiency greater than compressor-driven refrigerator.

  11. Eyespots divert attacks by fish.

    PubMed

    Kjernsmo, Karin; Merilaita, Sami

    2013-09-01

    Eyespots (colour patterns consisting of concentric rings) are found in a wide range of animal taxa and are often assumed to have an anti-predator function. Previous experiments have found strong evidence for an intimidating effect of eyespots against passerine birds. Some eyespots have been suggested to increase prey survival by diverting attacks towards less vital body parts or a direction that would facilitate escape. While eyespots in aquatic environments are widespread, their function is extremely understudied. Therefore, we investigated the protective function of eyespots against attacking fish. We used artificial prey and predator-naive three-spined sticklebacks (Gasterosteus aculeatus) as predators to test both the diversion (deflection) and the intimidation hypothesis. Interestingly, our results showed that eyespots smaller than the fish' own eye very effectively draw the attacks of the fish towards them. Furthermore, our experiment also showed that this was not due to the conspicuousness of the eyespot, because attack latency did not differ between prey items with and without eyespots. We found little support for an intimidating effect by larger eyespots. Even though also other markings might misdirect attacks, we can conclude that the misdirecting function may have played an important role in the evolution of eyespots in aquatic environments. PMID:23864602

  12. Eyespots divert attacks by fish

    PubMed Central

    Kjernsmo, Karin; Merilaita, Sami

    2013-01-01

    Eyespots (colour patterns consisting of concentric rings) are found in a wide range of animal taxa and are often assumed to have an anti-predator function. Previous experiments have found strong evidence for an intimidating effect of eyespots against passerine birds. Some eyespots have been suggested to increase prey survival by diverting attacks towards less vital body parts or a direction that would facilitate escape. While eyespots in aquatic environments are widespread, their function is extremely understudied. Therefore, we investigated the protective function of eyespots against attacking fish. We used artificial prey and predator-naive three-spined sticklebacks (Gasterosteus aculeatus) as predators to test both the diversion (deflection) and the intimidation hypothesis. Interestingly, our results showed that eyespots smaller than the fish’ own eye very effectively draw the attacks of the fish towards them. Furthermore, our experiment also showed that this was not due to the conspicuousness of the eyespot, because attack latency did not differ between prey items with and without eyespots. We found little support for an intimidating effect by larger eyespots. Even though also other markings might misdirect attacks, we can conclude that the misdirecting function may have played an important role in the evolution of eyespots in aquatic environments. PMID:23864602

  13. Eyespots divert attacks by fish.

    PubMed

    Kjernsmo, Karin; Merilaita, Sami

    2013-09-01

    Eyespots (colour patterns consisting of concentric rings) are found in a wide range of animal taxa and are often assumed to have an anti-predator function. Previous experiments have found strong evidence for an intimidating effect of eyespots against passerine birds. Some eyespots have been suggested to increase prey survival by diverting attacks towards less vital body parts or a direction that would facilitate escape. While eyespots in aquatic environments are widespread, their function is extremely understudied. Therefore, we investigated the protective function of eyespots against attacking fish. We used artificial prey and predator-naive three-spined sticklebacks (Gasterosteus aculeatus) as predators to test both the diversion (deflection) and the intimidation hypothesis. Interestingly, our results showed that eyespots smaller than the fish' own eye very effectively draw the attacks of the fish towards them. Furthermore, our experiment also showed that this was not due to the conspicuousness of the eyespot, because attack latency did not differ between prey items with and without eyespots. We found little support for an intimidating effect by larger eyespots. Even though also other markings might misdirect attacks, we can conclude that the misdirecting function may have played an important role in the evolution of eyespots in aquatic environments.

  14. Pregnancy Complications: Placental Abruption

    MedlinePlus

    ... page It's been added to your dashboard . The placenta attaches to the wall of the uterus (womb) ... abruption is a serious condition in which the placenta separates from the wall of the uterus before ...

  15. 30 CFR 250.1613 - Diverter systems.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... installed in any part of a diverter system. There shall be a minimum number of turns in the vent line(s) downstream of the spool outlet flange, and the radius of curvature of turns shall be as large as...

  16. The economics of abrupt climate change.

    PubMed

    Perrings, Charles

    2003-09-15

    The US National Research Council defines abrupt climate change as a change of state that is sufficiently rapid and sufficiently widespread in its effects that economies are unprepared or incapable of adapting. This may be too restrictive a definition, but abrupt climate change does have implications for the choice between the main response options: mitigation (which reduces the risks of climate change) and adaptation (which reduces the costs of climate change). The paper argues that by (i) increasing the costs of change and the potential growth of consumption, and (ii) reducing the time to change, abrupt climate change favours mitigation over adaptation. Furthermore, because the implications of change are fundamentally uncertain and potentially very high, it favours a precautionary approach in which mitigation buys time for learning. Adaptation-oriented decision tools, such as scenario planning, are inappropriate in these circumstances. Hence learning implies the use of probabilistic models that include socioeconomic feedbacks.

  17. Basic mechanism for abrupt monsoon transitions

    PubMed Central

    Levermann, Anders; Schewe, Jacob; Petoukhov, Vladimir; Held, Hermann

    2009-01-01

    Monsoon systems influence the livelihood of hundreds of millions of people. During the Holocene and last glacial period, rainfall in India and China has undergone strong and abrupt changes. Though details of monsoon circulations are complicated, observations reveal a defining moisture-advection feedback that dominates the seasonal heat balance and might act as an internal amplifier, leading to abrupt changes in response to relatively weak external perturbations. Here we present a minimal conceptual model capturing this positive feedback. The basic equations, motivated by observed relations, yield a threshold behavior, robust with respect to addition of other physical processes. Below this threshold in net radiative influx, R c, no conventional monsoon can develop; above R c, two stable regimes exist. We identify a nondimensional parameter l that defines the threshold and makes monsoon systems comparable with respect to the character of their abrupt transition. This dynamic similitude may be helpful in understanding past and future variations in monsoon circulation. Within the restrictions of the model, we compute R c for current monsoon systems in India, China, the Bay of Bengal, West Africa, North America, and Australia, where moisture advection is the main driver of the circulation. PMID:19858472

  18. Variable Frequency Diverter Actuation for Flow Control

    NASA Technical Reports Server (NTRS)

    Culley, Dennis E.

    2006-01-01

    The design and development of an actively controlled fluidic actuator for flow control applications is explored. The basic device, with one input and two output channels, takes advantage of the Coanda effect to force a fluid jet to adhere to one of two axi-symmetric surfaces. The resultant flow is bi-stable, producing a constant flow from one output channel, until a disturbance force applied at the control point causes the flow to switch to the alternate output channel. By properly applying active control the output flows can be manipulated to provide a high degree of modulation over a wide and variable range of frequency and duty cycle. In this study the momentary operative force is applied by small, high speed isolation valves of which several different types are examined. The active fluidic diverter actuator is shown to work in several configurations including that in which the operator valves are referenced to atmosphere as well as to a source common with the power stream.

  19. LEE VINING INTAKE LOOKING NORTH. DIVERTED WATER FOR CITY OF ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    LEE VINING INTAKE LOOKING NORTH. DIVERTED WATER FOR CITY OF LOS ANGELES USED TO GO OUT VIA COVERED CONDUIT TO RIGHT OF PICTURE SPACE. SCORCHED SAGE IN FOREGROUND FROM RECENT FOREST FIRE - Los Angeles Aqueduct, Lee Vining Intake Structure, Los Angeles, Los Angeles County, CA

  20. Microstructured Thin Film Nitinol for a Neurovascular Flow-Diverter.

    PubMed

    Chen, Yanfei; Howe, Connor; Lee, Yongkuk; Cheon, Seongsik; Yeo, Woon-Hong; Chun, Youngjae

    2016-01-01

    A cerebral aneurysm occurs as a result of a weakened blood vessel, which allows blood to flow into a sac or a ballooned section. Recent advancement shows that a new device, 'flow-diverter', can divert blood flow away from the aneurysm sac. People found that a flow-diverter based on thin film nitinol (TFN), works very effectively, however there are no studies proving the mechanical safety in irregular, curved blood vessels. Here, we study the mechanical behaviors and structural safety of a novel microstructured TFN membrane through the computational and experimental studies, which establish the fundamental aspects of stretching and bending mechanics of the structure. The result shows a hyper-elastic behavior of the TFN with a negligible strain change up to 180° in bending and over 500% in radial stretching, which is ideal in the use in neurovascular curved arteries. The simulation determines the optimal joint locations between the TFN and stent frame. In vitro experimental test qualitatively demonstrates the mechanical flexibility of the flow-diverter with multi-modal bending. In vivo micro X-ray and histopathology study demonstrate that the TFN can be conformally deployed in the curved blood vessel of a swine model without any significant complications or abnormalities. PMID:27009500

  1. Microstructured Thin Film Nitinol for a Neurovascular Flow-Diverter.

    PubMed

    Chen, Yanfei; Howe, Connor; Lee, Yongkuk; Cheon, Seongsik; Yeo, Woon-Hong; Chun, Youngjae

    2016-03-24

    A cerebral aneurysm occurs as a result of a weakened blood vessel, which allows blood to flow into a sac or a ballooned section. Recent advancement shows that a new device, 'flow-diverter', can divert blood flow away from the aneurysm sac. People found that a flow-diverter based on thin film nitinol (TFN), works very effectively, however there are no studies proving the mechanical safety in irregular, curved blood vessels. Here, we study the mechanical behaviors and structural safety of a novel microstructured TFN membrane through the computational and experimental studies, which establish the fundamental aspects of stretching and bending mechanics of the structure. The result shows a hyper-elastic behavior of the TFN with a negligible strain change up to 180° in bending and over 500% in radial stretching, which is ideal in the use in neurovascular curved arteries. The simulation determines the optimal joint locations between the TFN and stent frame. In vitro experimental test qualitatively demonstrates the mechanical flexibility of the flow-diverter with multi-modal bending. In vivo micro X-ray and histopathology study demonstrate that the TFN can be conformally deployed in the curved blood vessel of a swine model without any significant complications or abnormalities.

  2. Analysis of abrupt transitions in ecological systems

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The occurrence and causes of abrupt transitions, thresholds, or regime shifts between ecosystem states are of great concern and the likelihood of such transitions is increasing for many ecological systems. General understanding of abrupt transitions has been advanced by theory, but hindered by the l...

  3. Numerical Studies of a Fluidic Diverter for Flow Control

    NASA Technical Reports Server (NTRS)

    Gokoglu, Suleyman A.; Kuczmarski, Maria A.; Culley, Dennis E.; Raghu, Surya

    2009-01-01

    The internal flow structure in a specific fluidic diverter is studied over a range from low subsonic to sonic inlet conditions by a time-dependent numerical analysis. The understanding will aid in the development of fluidic diverters with minimum pressure losses and advanced designs of flow control actuators. The velocity, temperature and pressure fields are calculated for subsonic conditions and the self-induced oscillatory behavior of the flow is successfully predicted. The results of our numerical studies have excellent agreement with our experimental measurements of oscillation frequencies. The acoustic speed in the gaseous medium is determined to be a key factor for up to sonic conditions in governing the mechanism of initiating the oscillations as well as determining its frequency. The feasibility of employing plasma actuation with a minimal perturbation level is demonstrated in steady-state calculations to also produce oscillation frequencies of our own choosing instead of being dependent on the fixed-geometry fluidic device.

  4. Method of temporarily plagging portions of a subterranean formation using a diverting agent

    SciTech Connect

    Dill, W. R.; Gdanski, R. D.

    1985-07-09

    A method of temporarily plugging a subterranean formation using a diverting material comprising an aqueous carrier liquid and a diverting agent comprising a solid azo compound having an azo component and a methylenic component.

  5. Response of seafloor ecosystems to abrupt global climate change

    PubMed Central

    Moffitt, Sarah E.; Hill, Tessa M.; Roopnarine, Peter D.; Kennett, James P.

    2015-01-01

    Anthropogenic climate change is predicted to decrease oceanic oxygen (O2) concentrations, with potentially significant effects on marine ecosystems. Geologically recent episodes of abrupt climatic warming provide opportunities to assess the effects of changing oxygenation on marine communities. Thus far, this knowledge has been largely restricted to investigations using Foraminifera, with little being known about ecosystem-scale responses to abrupt, climate-forced deoxygenation. We here present high-resolution records based on the first comprehensive quantitative analysis, to our knowledge, of changes in marine metazoans (Mollusca, Echinodermata, Arthropoda, and Annelida; >5,400 fossils and trace fossils) in response to the global warming associated with the last glacial to interglacial episode. The molluscan archive is dominated by extremophile taxa, including those containing endosymbiotic sulfur-oxidizing bacteria (Lucinoma aequizonatum) and those that graze on filamentous sulfur-oxidizing benthic bacterial mats (Alia permodesta). This record, from 16,100 to 3,400 y ago, demonstrates that seafloor invertebrate communities are subject to major turnover in response to relatively minor inferred changes in oxygenation (>1.5 to <0.5 mL⋅L−1 [O2]) associated with abrupt (<100 y) warming of the eastern Pacific. The biotic turnover and recovery events within the record expand known rates of marine biological recovery by an order of magnitude, from <100 to >1,000 y, and illustrate the crucial role of climate and oceanographic change in driving long-term successional changes in ocean ecosystems. PMID:25825727

  6. Response of seafloor ecosystems to abrupt global climate change

    NASA Astrophysics Data System (ADS)

    Moffitt, Sarah E.; Hill, Tessa M.; Roopnarine, Peter D.; Kennett, James P.

    2015-04-01

    Anthropogenic climate change is predicted to decrease oceanic oxygen (O2) concentrations, with potentially significant effects on marine ecosystems. Geologically recent episodes of abrupt climatic warming provide opportunities to assess the effects of changing oxygenation on marine communities. Thus far, this knowledge has been largely restricted to investigations using Foraminifera, with little being known about ecosystem-scale responses to abrupt, climate-forced deoxygenation. We here present high-resolution records based on the first comprehensive quantitative analysis, to our knowledge, of changes in marine metazoans (Mollusca, Echinodermata, Arthropoda, and Annelida; >5,400 fossils and trace fossils) in response to the global warming associated with the last glacial to interglacial episode. The molluscan archive is dominated by extremophile taxa, including those containing endosymbiotic sulfur-oxidizing bacteria (Lucinoma aequizonatum) and those that graze on filamentous sulfur-oxidizing benthic bacterial mats (Alia permodesta). This record, from 16,100 to 3,400 y ago, demonstrates that seafloor invertebrate communities are subject to major turnover in response to relatively minor inferred changes in oxygenation (>1.5 to <0.5 mLṡL-1 [O2]) associated with abrupt (<100 y) warming of the eastern Pacific. The biotic turnover and recovery events within the record expand known rates of marine biological recovery by an order of magnitude, from <100 to >1,000 y, and illustrate the crucial role of climate and oceanographic change in driving long-term successional changes in ocean ecosystems.

  7. Response of seafloor ecosystems to abrupt global climate change.

    PubMed

    Moffitt, Sarah E; Hill, Tessa M; Roopnarine, Peter D; Kennett, James P

    2015-04-14

    Anthropogenic climate change is predicted to decrease oceanic oxygen (O2) concentrations, with potentially significant effects on marine ecosystems. Geologically recent episodes of abrupt climatic warming provide opportunities to assess the effects of changing oxygenation on marine communities. Thus far, this knowledge has been largely restricted to investigations using Foraminifera, with little being known about ecosystem-scale responses to abrupt, climate-forced deoxygenation. We here present high-resolution records based on the first comprehensive quantitative analysis, to our knowledge, of changes in marine metazoans (Mollusca, Echinodermata, Arthropoda, and Annelida; >5,400 fossils and trace fossils) in response to the global warming associated with the last glacial to interglacial episode. The molluscan archive is dominated by extremophile taxa, including those containing endosymbiotic sulfur-oxidizing bacteria (Lucinoma aequizonatum) and those that graze on filamentous sulfur-oxidizing benthic bacterial mats (Alia permodesta). This record, from 16,100 to 3,400 y ago, demonstrates that seafloor invertebrate communities are subject to major turnover in response to relatively minor inferred changes in oxygenation (>1.5 to <0.5 mL⋅L(-1) [O2]) associated with abrupt (<100 y) warming of the eastern Pacific. The biotic turnover and recovery events within the record expand known rates of marine biological recovery by an order of magnitude, from <100 to >1,000 y, and illustrate the crucial role of climate and oceanographic change in driving long-term successional changes in ocean ecosystems.

  8. Response of seafloor ecosystems to abrupt global climate change.

    PubMed

    Moffitt, Sarah E; Hill, Tessa M; Roopnarine, Peter D; Kennett, James P

    2015-04-14

    Anthropogenic climate change is predicted to decrease oceanic oxygen (O2) concentrations, with potentially significant effects on marine ecosystems. Geologically recent episodes of abrupt climatic warming provide opportunities to assess the effects of changing oxygenation on marine communities. Thus far, this knowledge has been largely restricted to investigations using Foraminifera, with little being known about ecosystem-scale responses to abrupt, climate-forced deoxygenation. We here present high-resolution records based on the first comprehensive quantitative analysis, to our knowledge, of changes in marine metazoans (Mollusca, Echinodermata, Arthropoda, and Annelida; >5,400 fossils and trace fossils) in response to the global warming associated with the last glacial to interglacial episode. The molluscan archive is dominated by extremophile taxa, including those containing endosymbiotic sulfur-oxidizing bacteria (Lucinoma aequizonatum) and those that graze on filamentous sulfur-oxidizing benthic bacterial mats (Alia permodesta). This record, from 16,100 to 3,400 y ago, demonstrates that seafloor invertebrate communities are subject to major turnover in response to relatively minor inferred changes in oxygenation (>1.5 to <0.5 mL⋅L(-1) [O2]) associated with abrupt (<100 y) warming of the eastern Pacific. The biotic turnover and recovery events within the record expand known rates of marine biological recovery by an order of magnitude, from <100 to >1,000 y, and illustrate the crucial role of climate and oceanographic change in driving long-term successional changes in ocean ecosystems. PMID:25825727

  9. Method of using a diverting material for well treatment

    SciTech Connect

    Dill, W.R.

    1984-04-24

    The present invention relates to a diverting material or fluid-loss additive for use in subterranean formations penetrated by a well bore comprising graded phthalimide particles. The phthalimide particles are introduced into the formation in a carrier fluid. The carrier fluid can include gelling agents or any of the various salts known to be useful in fluids employed in subterranean formation treatment. The phthalimide particles can be used in elevated temperature oil and gas producing formations.

  10. Treatment as an alternative to prosecution: offenders diverted for treatment.

    PubMed

    Cooke, D J

    1991-06-01

    In Scotland, procurators fiscal (state prosecutors) can divert certain offenders from the court process into treatment. This paper describes the first diversion scheme in which offenders who are suspected of having psychological difficulties are referred for psychological and psychiatric treatment before, and generally in lieu of, prosecution. It is argued that the procurator fiscal is successful in selecting suitable cases for treatment: most people referred have significant psychological difficulties but have failed to obtain appropriate assistance through the normal channels of referral.

  11. Optimized Coolant-Flow Diverter For Increased Bearing Life

    NASA Technical Reports Server (NTRS)

    Subbaraman, Maria R.; Butner, Myles F.

    1995-01-01

    Coolant-flow diverter for rolling-element bearings in cryogenic turbopump designed to enhance cooling power of flow in contact with bearings and thereby reduce bearing wear. Delivers jets of coolant as close as possible to hot spots at points of contact between balls and race. Also imparts swirl that enhances beneficial pumping effect. Used with success in end ball bearing of high-pressure-oxidizer turbopump.

  12. Microstructured Thin Film Nitinol for a Neurovascular Flow-Diverter

    PubMed Central

    Chen, Yanfei; Howe, Connor; Lee, Yongkuk; Cheon, Seongsik; Yeo, Woon-Hong; Chun, Youngjae

    2016-01-01

    A cerebral aneurysm occurs as a result of a weakened blood vessel, which allows blood to flow into a sac or a ballooned section. Recent advancement shows that a new device, ‘flow-diverter’, can divert blood flow away from the aneurysm sac. People found that a flow-diverter based on thin film nitinol (TFN), works very effectively, however there are no studies proving the mechanical safety in irregular, curved blood vessels. Here, we study the mechanical behaviors and structural safety of a novel microstructured TFN membrane through the computational and experimental studies, which establish the fundamental aspects of stretching and bending mechanics of the structure. The result shows a hyper-elastic behavior of the TFN with a negligible strain change up to 180° in bending and over 500% in radial stretching, which is ideal in the use in neurovascular curved arteries. The simulation determines the optimal joint locations between the TFN and stent frame. In vitro experimental test qualitatively demonstrates the mechanical flexibility of the flow-diverter with multi-modal bending. In vivo micro X-ray and histopathology study demonstrate that the TFN can be conformally deployed in the curved blood vessel of a swine model without any significant complications or abnormalities. PMID:27009500

  13. Microstructured Thin Film Nitinol for a Neurovascular Flow-Diverter

    NASA Astrophysics Data System (ADS)

    Chen, Yanfei; Howe, Connor; Lee, Yongkuk; Cheon, Seongsik; Yeo, Woon-Hong; Chun, Youngjae

    2016-03-01

    A cerebral aneurysm occurs as a result of a weakened blood vessel, which allows blood to flow into a sac or a ballooned section. Recent advancement shows that a new device, ‘flow-diverter’, can divert blood flow away from the aneurysm sac. People found that a flow-diverter based on thin film nitinol (TFN), works very effectively, however there are no studies proving the mechanical safety in irregular, curved blood vessels. Here, we study the mechanical behaviors and structural safety of a novel microstructured TFN membrane through the computational and experimental studies, which establish the fundamental aspects of stretching and bending mechanics of the structure. The result shows a hyper-elastic behavior of the TFN with a negligible strain change up to 180° in bending and over 500% in radial stretching, which is ideal in the use in neurovascular curved arteries. The simulation determines the optimal joint locations between the TFN and stent frame. In vitro experimental test qualitatively demonstrates the mechanical flexibility of the flow-diverter with multi-modal bending. In vivo micro X-ray and histopathology study demonstrate that the TFN can be conformally deployed in the curved blood vessel of a swine model without any significant complications or abnormalities.

  14. 30 CFR 250.431 - What are the diverter design and installation requirements?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... part of the diverter system; (e) Minimize the number of turns (only one 90-degree turn allowed for each line for bottom-founded drilling units) in the diverter lines, maximize the radius of curvature of turns, and target all right angles and sharp turns; (f) Anchor and support the entire diverter system...

  15. Abrupt climate change and extinction events

    NASA Technical Reports Server (NTRS)

    Crowley, Thomas J.

    1988-01-01

    There is a growing body of theoretical and empirical support for the concept of instabilities in the climate system, and indications that abrupt climate change may in some cases contribute to abrupt extinctions. Theoretical indications of instabilities can be found in a broad spectrum of climate models (energy balance models, a thermohaline model of deep-water circulation, atmospheric general circulation models, and coupled ocean-atmosphere models). Abrupt transitions can be of several types and affect the environment in different ways. There is increasing evidence for abrupt climate change in the geologic record and involves both interglacial-glacial scale transitions and the longer-term evolution of climate over the last 100 million years. Records from the Cenozoic clearly show that the long-term trend is characterized by numerous abrupt steps where the system appears to be rapidly moving to a new equilibrium state. The long-term trend probably is due to changes associated with plate tectonic processes, but the abrupt steps most likely reflect instabilities in the climate system as the slowly changing boundary conditions caused the climate to reach some threshold critical point. A more detailed analysis of abrupt steps comes from high-resolution studies of glacial-interglacial fluctuations in the Pleistocene. Comparison of climate transitions with the extinction record indicates that many climate and biotic transitions coincide. The Cretaceous-Tertiary extinction is not a candidate for an extinction event due to instabilities in the climate system. It is quite possible that more detailed comparisons and analysis will indicate some flaws in the climate instability-extinction hypothesis, but at present it appears to be a viable candidate as an alternate mechanism for causing abrupt environmental changes and extinctions.

  16. Assessing the credibility of diverting through containment penetrations

    SciTech Connect

    Cooley, J.N.; Swindle, D.W. Jr.

    1980-01-01

    A viable approach has been developed for identifying those containment penetrations in a nuclear fuel reprocessing plant which are credible diversion routes. The approach is based upon systematic engineering and design analyses and is applied to each type of penetration to determine which penetrations could be utilized to divert nuclear material from a reprocessing facility. The approach is described and the results of an application are discussed. In addition, the concept of credibility is developed and discussed. For a typical reprocessing plant design, the number of penetrations determined to be credible without process or piping modifications was approx. 16% of the penetrations originally identified.

  17. Diverter AI based decision aid, phases 1 and 2

    NASA Technical Reports Server (NTRS)

    Sexton, George A.; Bayles, Scott J.; Patterson, Robert W.; Schulke, Duane A.; Williams, Deborah C.

    1989-01-01

    It was determined that a system to incorporate artificial intelligence (AI) into airborne flight management computers is feasible. The AI functions that would be most useful to the pilot are to perform situational assessment, evaluate outside influences on the contemplated rerouting, perform flight planning/replanning, and perform maneuver planning. A study of the software architecture and software tools capable of demonstrating Diverter was also made. A skeletal planner known as the Knowledge Acquisition Development Tool (KADET), which is a combination script-based and rule-based system, was used to implement the system. A prototype system was developed which demonstrates advanced in-flight planning/replanning capabilities.

  18. Monsoon abrupt change and its dominant factors

    NASA Astrophysics Data System (ADS)

    Yao, Qiang; Fu, Conbin

    2010-05-01

    Abrupt changes of monsoon are apparent in the geological record of climate over various timescales. During Holocene and last glacial period, rainfall in India and China has undergone strong and abrupt changes. In this context, we regard monsoon as dissipative system, which has many characteristic times, to contrive various factors and corresponding mechanism dominated in monsoon's abrupt change. The abrupt change of monsoon over inter-decadal to century timescales may be resulting from different fluctuation's competition, which impose on the inner basic physic processes. In order to find out the key factors which control the monsoon's abrupt change, starting from the seminar works by Leith, who proposed to employ the Fluctuation-dissipation Response theory(FDR) to study the response of climatic systems to changes in the external forcing, many authors applied this relation to different geophysical problems, ranging from simplified models to general circulation models and to the covariance of satellite radiance spectra. The FDR has been originally developed in the framework of statistical mechanics of Hamiltonian systems, nevertheless a generalized FDR holds under rather general hypotheses, regardless of the Hamiltonian, or equilibrium nature of the system. Our work verify the FDR theory' applicability in monsoon systems, which demonstrates that it can reveal clear and fundamental factors that control monsoon's abrupt change. By making use of FDR theory, combined with observational data analysis, we have already seen how monsoon systems with many characteristics times, different correlation functions behave differently and a variety of timescales emerges, which correspond to the different decay times of the correlation functions. Via theoretical and data analysis, it is suggested that each monsoon system has experienced several significant abrupt changes in 20th century. The global main monsoon rainfall has undergone an obvious abrupt jump in the mid- and late 1970s

  19. Abrupt Impacts of Climate Change: Anticipating Surprises

    NASA Astrophysics Data System (ADS)

    White, James W. C.; Alley, Richard B.; Archer, David E.; Barnosky, Anthony D.; Dunlea, Edward; Foley, Jonathan; Fu, Rong; Holland, Marika M.; Lozier, M. Susan; Schmitt, Johanna; Smith, Laurence C.; Sugihara, George; Thompson, David W. J.; Weaver, Andrew J.; Wofsy, Steven C.

    2014-05-01

    Levels of carbon dioxide and other greenhouse gases in Earth's atmosphere are exceeding levels recorded in the past millions of years, and thus climate is being forced beyond the range of the recent geological era. Lacking concerted action by the world's nations, it is clear that the future climate will be warmer, sea levels will rise, global rainfall patterns will change, and ecosystems will be altered. However, there is still uncertainty about how we will arrive at that future climate state. Although many projections of future climatic conditions have predicted steadily changing conditions giving the impression that communities have time to gradually adapt, the scientific community has been paying increasing attention to the possibility that at least some changes will be abrupt, perhaps crossing a threshold or "tipping point" to change so quickly that there will be little time to react. This presentation will synopsize the new US National Research Council Report, Abrupt Impacts of Climate Change: Anticipating Surprises, highlighting areas of increased and decreased concern, as well as areas of new concern. Emphasis is placed on not only abrupt change in physical climate, but on abrupt changes in human and natural systems that can occur as a result of a slowly changing climate. The report calls for action now on an abrupt change early warning system (ACEWS) if societies are to be resilient to climate change.

  20. Experimental Flow Characterization of a Flow Diverting Device

    NASA Astrophysics Data System (ADS)

    Sparrow, Eph; Chow, Ricky; Campbell, Gary; Divani, Afshin; Sheng, Jian

    2012-11-01

    Flow diverters, such as the Pipeline Embolization Device, are a new class of endovascular devices for the treatment of intracranial aneurysms. While clinical studies have demonstrated safety and efficacy, their impact on intra-aneurysmal flow is not confirmed experimentally. As such, optimization of the flow diversion behavior is not currently possible. A quasi-3D PIV technique was developed and applied in various glass models at Re = 275 and 550 to determine the changes to flow characteristics due to the deployment of a flow diverter across the aneurysm neck. Outcomes such as mean velocity, wall shear stress, and others metrics will be presented. Glass models with varying radii of curvature and aneurysm locations will be examined. Experiments were performed in a fully index-matched flow facility using ~10 μm diameter polystyrene particles doped with Rhodium 6G dye. The particles were illuminated with a 532nm laser sheet and observed with a CCD camera and a 592nm +/-43 nm bandpass filter. A quasi 3D flow field was reconstructed from multiple orthogonal planes (spaced 0.4mm apart) encompassing the entire glass model. Wall stresses were evaluated from the near-wall flow viscous stresses.

  1. Abrupt climate change: can society cope?

    PubMed

    Hulme, Mike

    2003-09-15

    Consideration of abrupt climate change has generally been incorporated neither in analyses of climate-change impacts nor in the design of climate adaptation strategies. Yet the possibility of abrupt climate change triggered by human perturbation of the climate system is used to support the position of both those who urge stronger and earlier mitigative action than is currently being contemplated and those who argue that the unknowns in the Earth system are too large to justify such early action. This paper explores the question of abrupt climate change in terms of its potential implications for society, focusing on the UK and northwest Europe in particular. The nature of abrupt climate change and the different ways in which it has been defined and perceived are examined. Using the example of the collapse of the thermohaline circulation (THC), the suggested implications for society of abrupt climate change are reviewed; previous work has been largely speculative and has generally considered the implications only from economic and ecological perspectives. Some observations about the implications from a more social and behavioural science perspective are made. If abrupt climate change simply implies changes in the occurrence or intensity of extreme weather events, or an accelerated unidirectional change in climate, the design of adaptation to climate change can proceed within the existing paradigm, with appropriate adjustments. Limits to adaptation in some sectors or regions may be reached, and the costs of appropriate adaptive behaviour may be large, but strategy can develop on the basis of a predicted long-term unidirectional change in climate. It would be more challenging, however, if abrupt climate change implied a directional change in climate, as, for example, may well occur in northwest Europe following a collapse of the THC. There are two fundamental problems for society associated with such an outcome: first, the future changes in climate currently being

  2. Abrupt climate change: can society cope?

    PubMed

    Hulme, Mike

    2003-09-15

    Consideration of abrupt climate change has generally been incorporated neither in analyses of climate-change impacts nor in the design of climate adaptation strategies. Yet the possibility of abrupt climate change triggered by human perturbation of the climate system is used to support the position of both those who urge stronger and earlier mitigative action than is currently being contemplated and those who argue that the unknowns in the Earth system are too large to justify such early action. This paper explores the question of abrupt climate change in terms of its potential implications for society, focusing on the UK and northwest Europe in particular. The nature of abrupt climate change and the different ways in which it has been defined and perceived are examined. Using the example of the collapse of the thermohaline circulation (THC), the suggested implications for society of abrupt climate change are reviewed; previous work has been largely speculative and has generally considered the implications only from economic and ecological perspectives. Some observations about the implications from a more social and behavioural science perspective are made. If abrupt climate change simply implies changes in the occurrence or intensity of extreme weather events, or an accelerated unidirectional change in climate, the design of adaptation to climate change can proceed within the existing paradigm, with appropriate adjustments. Limits to adaptation in some sectors or regions may be reached, and the costs of appropriate adaptive behaviour may be large, but strategy can develop on the basis of a predicted long-term unidirectional change in climate. It would be more challenging, however, if abrupt climate change implied a directional change in climate, as, for example, may well occur in northwest Europe following a collapse of the THC. There are two fundamental problems for society associated with such an outcome: first, the future changes in climate currently being

  3. Abrupt tropical climate change: Past and present

    PubMed Central

    Thompson, Lonnie G.; Mosley-Thompson, Ellen; Brecher, Henry; Davis, Mary; León, Blanca; Les, Don; Lin, Ping-Nan; Mashiotta, Tracy; Mountain, Keith

    2006-01-01

    Three lines of evidence for abrupt tropical climate change, both past and present, are presented. First, annually and decadally averaged δ18O and net mass-balance histories for the last 400 and 2,000 yr, respectively, demonstrate that the current warming at high elevations in the mid- to low latitudes is unprecedented for at least the last 2 millennia. Second, the continuing retreat of most mid- to low-latitude glaciers, many having persisted for thousands of years, signals a recent and abrupt change in the Earth’s climate system. Finally, rooted, soft-bodied wetland plants, now exposed along the margins as the Quelccaya ice cap (Peru) retreats, have been radiocarbon dated and, when coupled with other widespread proxy evidence, provide strong evidence for an abrupt mid-Holocene climate event that marked the transition from early Holocene (pre-5,000-yr-B.P.) conditions to cooler, late Holocene (post-5,000-yr-B.P.) conditions. This abrupt event, ≈5,200 yr ago, was widespread and spatially coherent through much of the tropics and was coincident with structural changes in several civilizations. These three lines of evidence argue that the present warming and associated glacier retreat are unprecedented in some areas for at least 5,200 yr. The ongoing global-scale, rapid retreat of mountain glaciers is not only contributing to global sea-level rise but also threatening freshwater supplies in many of the world’s most populous regions. PMID:16815970

  4. Detection of abrupt changes in dynamic systems

    NASA Technical Reports Server (NTRS)

    Willsky, A. S.

    1984-01-01

    Some of the basic ideas associated with the detection of abrupt changes in dynamic systems are presented. Multiple filter-based techniques and residual-based method and the multiple model and generalized likelihood ratio methods are considered. Issues such as the effect of unknown onset time on algorithm complexity and structure and robustness to model uncertainty are discussed.

  5. Abrupt tropical climate change: past and present.

    PubMed

    Thompson, Lonnie G; Mosley-Thompson, Ellen; Brecher, Henry; Davis, Mary; León, Blanca; Les, Don; Lin, Ping-Nan; Mashiotta, Tracy; Mountain, Keith

    2006-07-11

    Three lines of evidence for abrupt tropical climate change, both past and present, are presented. First, annually and decadally averaged delta(18)O and net mass-balance histories for the last 400 and 2,000 yr, respectively, demonstrate that the current warming at high elevations in the mid- to low latitudes is unprecedented for at least the last 2 millennia. Second, the continuing retreat of most mid- to low-latitude glaciers, many having persisted for thousands of years, signals a recent and abrupt change in the Earth's climate system. Finally, rooted, soft-bodied wetland plants, now exposed along the margins as the Quelccaya ice cap (Peru) retreats, have been radiocarbon dated and, when coupled with other widespread proxy evidence, provide strong evidence for an abrupt mid-Holocene climate event that marked the transition from early Holocene (pre-5,000-yr-B.P.) conditions to cooler, late Holocene (post-5,000-yr-B.P.) conditions. This abrupt event, approximately 5,200 yr ago, was widespread and spatially coherent through much of the tropics and was coincident with structural changes in several civilizations. These three lines of evidence argue that the present warming and associated glacier retreat are unprecedented in some areas for at least 5,200 yr. The ongoing global-scale, rapid retreat of mountain glaciers is not only contributing to global sea-level rise but also threatening freshwater supplies in many of the world's most populous regions.

  6. Preliminary skyshine calculations for the Poloidal Diverter Tokamak Experiment

    SciTech Connect

    Nigg, D.W.; Wheeler, F.J.

    1981-01-01

    A calculational model is presented to estimate the radiation dose, due to the skyshine effect, in the control room and at the site boundary of the Poloidal Diverter Experiment (PDX) facility at Princeton University which requires substantial radiation shielding. The required composition and thickness of a water-filled roof shield that would reduce this effect to an acceptable level is computed, using an efficient one-dimensional model with an Sn calculation in slab geometry. The actual neutron skyshine dose is computed using a Monte Carlo model with the neutron source at the roof surface obtained from the slab Sn calculation, and the capture gamma dose is computed using a simple point-kernel single-scatter method. It is maintained that the slab model provides the exact probability of leakage out the top surface of the roof and that it is nearly as accurate as and much less costly than multi-dimensional techniques.

  7. Linear tearing modes calculation for diverted tokamak configurations

    SciTech Connect

    Atanasiu, C.V.; Guenter, S.; Lackner, K.; Moraru, A.; Zakharov, L.E.; Subbotin, A.A.

    2004-12-01

    Writing the expression of the potential energy in terms of the perturbation of the flux function, and performing an Euler minimization, one obtains a system of ordinary differential equations in that perturbation. For a diverted configuration, the usual vanishing boundary conditions for the perturbed flux function at the magnetic axis and at infinity can no longer be used. An approach to fix 'natural' boundary conditions for the perturbed flux function just at the plasma boundary has been developed; this replaces the vanishing boundary conditions at infinity. To obtain the necessary metric coefficients from an equilibrium solver, a function exhibiting the same singularity at the X point has been introduced, and thus the separatrix contour was described by a reduced number of moments.

  8. The 'Sphere': A Dedicated Bifurcation Aneurysm Flow-Diverter Device.

    PubMed

    Peach, Thomas; Cornhill, J Frederick; Nguyen, Anh; Riina, Howard; Ventikos, Yiannis

    2014-01-01

    We present flow-based results from the early stage design cycle, based on computational modeling, of a prototype flow-diverter device, known as the 'Sphere', intended to treat bifurcation aneurysms of the cerebral vasculature. The device is available in a range of diameters and geometries and is constructed from a single loop of NITINOL(®) wire. The 'Sphere' reduces aneurysm inflow by means of a high-density, patterned, elliptical surface that partially occludes the aneurysm neck. The device is secured in the healthy parent vessel by two armatures in the shape of open loops, resulting in negligible disruption of parent or daughter vessel flow. The device is virtually deployed in six anatomically accurate bifurcation aneurysms: three located at the Basilar tip and three located at the terminus bifurcation of the Internal Carotid artery (at the meeting of the middle cerebral and anterior cerebral arteries). Both steady state and transient flow simulations reveal that the device presents with a range of aneurysm inflow reductions, with mean flow reductions falling in the range of 30.6-71.8% across the different geometries. A significant difference is noted between steady state and transient simulations in one geometry, where a zone of flow recirculation is not captured in the steady state simulation. Across all six aneurysms, the device reduces the WSS magnitude within the aneurysm sac, resulting in a hemodynamic environment closer to that of a healthy vessel. We conclude from extensive CFD analysis that the 'Sphere' device offers very significant levels of flow reduction in a number of anatomically accurate aneurysm sizes and locations, with many advantages compared to current clinical cylindrical flow-diverter designs. Analysis of the device's mechanical properties and deployability will follow in future publications.

  9. Smart-Divert Powered Descent Guidance to Avoid the Backshell Landing Dispersion Ellipse

    NASA Technical Reports Server (NTRS)

    Carson, John M.; Acikmese, Behcet

    2013-01-01

    A smart-divert capability has been added into the Powered Descent Guidance (PDG) software originally developed for Mars pinpoint and precision landing. The smart-divert algorithm accounts for the landing dispersions of the entry backshell, which separates from the lander vehicle at the end of the parachute descent phase and prior to powered descent. The smart-divert PDG algorithm utilizes the onboard fuel and vehicle thrust vectoring to mitigate landing error in an intelligent way: ensuring that the lander touches down with minimum- fuel usage at the minimum distance from the desired landing location that also avoids impact by the descending backshell. The smart-divert PDG software implements a computationally efficient, convex formulation of the powered-descent guidance problem to provide pinpoint or precision-landing guidance solutions that are fuel-optimal and satisfy physical thrust bound and pointing constraints, as well as position and speed constraints. The initial smart-divert implementation enforced a lateral-divert corridor parallel to the ground velocity vector; this was based on guidance requirements for MSL (Mars Science Laboratory) landings. This initial method was overly conservative since the divert corridor was infinite in the down-range direction despite the backshell landing inside a calculable dispersion ellipse. Basing the divert constraint instead on a local tangent to the backshell dispersion ellipse in the direction of the desired landing site provides a far less conservative constraint. The resulting enhanced smart-divert PDG algorithm avoids impact with the descending backshell and has reduced conservatism.

  10. Abrupt climate change: Mechanisms, patterns, and impacts

    NASA Astrophysics Data System (ADS)

    Schultz, Colin

    2012-08-01

    In the span of only a few decades, the global temperature can soar by more than a dozen degrees Celsius, a feat that 20 years ago was considered improbable, if not impossible. But recent research in the nascent field of rapid climate change has upended the dominant views of decades past. Focusing primarily on events during and after the most recent glaciation, from 80,000 years ago, the AGU monograph Abrupt Climate Change: Mechanisms, Patterns, and Impacts, edited by Harunur Rashid, Leonid Polyak, and Ellen Mosley-Thompson, explores the transient climate transitions that were only recently uncovered in climate proxies around the world. In this interview, Eos talks to Harunur Rashid about piecing together ancient climes, the effect of abrupt change on historical civilizations, and why younger researchers may be more worried about modern warming than their teachers.

  11. Abruptness of Cascade Failures in Power Grids

    NASA Astrophysics Data System (ADS)

    Pahwa, Sakshi; Scoglio, Caterina; Scala, Antonio

    2014-01-01

    Electric power-systems are one of the most important critical infrastructures. In recent years, they have been exposed to extreme stress due to the increasing demand, the introduction of distributed renewable energy sources, and the development of extensive interconnections. We investigate the phenomenon of abrupt breakdown of an electric power-system under two scenarios: load growth (mimicking the ever-increasing customer demand) and power fluctuations (mimicking the effects of renewable sources). Our results on real, realistic and synthetic networks indicate that increasing the system size causes breakdowns to become more abrupt; in fact, mapping the system to a solvable statistical-physics model indicates the occurrence of a first order transition in the large size limit. Such an enhancement for the systemic risk failures (black-outs) with increasing network size is an effect that should be considered in the current projects aiming to integrate national power-grids into ``super-grids''.

  12. Abruptness of Cascade Failures in Power Grids

    PubMed Central

    Pahwa, Sakshi; Scoglio, Caterina; Scala, Antonio

    2014-01-01

    Electric power-systems are one of the most important critical infrastructures. In recent years, they have been exposed to extreme stress due to the increasing demand, the introduction of distributed renewable energy sources, and the development of extensive interconnections. We investigate the phenomenon of abrupt breakdown of an electric power-system under two scenarios: load growth (mimicking the ever-increasing customer demand) and power fluctuations (mimicking the effects of renewable sources). Our results on real, realistic and synthetic networks indicate that increasing the system size causes breakdowns to become more abrupt; in fact, mapping the system to a solvable statistical-physics model indicates the occurrence of a first order transition in the large size limit. Such an enhancement for the systemic risk failures (black-outs) with increasing network size is an effect that should be considered in the current projects aiming to integrate national power-grids into “super-grids”. PMID:24424239

  13. Abruptness of cascade failures in power grids.

    PubMed

    Pahwa, Sakshi; Scoglio, Caterina; Scala, Antonio

    2014-01-01

    Electric power-systems are one of the most important critical infrastructures. In recent years, they have been exposed to extreme stress due to the increasing demand, the introduction of distributed renewable energy sources, and the development of extensive interconnections. We investigate the phenomenon of abrupt breakdown of an electric power-system under two scenarios: load growth (mimicking the ever-increasing customer demand) and power fluctuations (mimicking the effects of renewable sources). Our results on real, realistic and synthetic networks indicate that increasing the system size causes breakdowns to become more abrupt; in fact, mapping the system to a solvable statistical-physics model indicates the occurrence of a first order transition in the large size limit. Such an enhancement for the systemic risk failures (black-outs) with increasing network size is an effect that should be considered in the current projects aiming to integrate national power-grids into "super-grids". PMID:24424239

  14. Abrupt percolation in small equilibrated networks

    NASA Astrophysics Data System (ADS)

    Matsoukas, Themis

    2015-05-01

    Networks can exhibit an abrupt transition in the form of a spontaneous self-organization of a sizable fraction of the population into a giant component of connected members. This behavior has been demonstrated in random graphs under suppressive rules that passively or actively attempt to delay the formation of the giant cluster. We show that suppressive rules are not a necessary condition for a sharp transition at the percolation threshold. Rather, a finite system with aggressive tendency to form a giant cluster may exhibit an instability at the percolation threshold that is relieved through an abrupt and discontinuous transition to the stable branch. We develop the theory for a class of equilibrated networks that produce this behavior and find that the discontinuous jump is especially pronounced in small networks but disappears when the size of the system is infinite.

  15. Abruptness of cascade failures in power grids.

    PubMed

    Pahwa, Sakshi; Scoglio, Caterina; Scala, Antonio

    2014-01-15

    Electric power-systems are one of the most important critical infrastructures. In recent years, they have been exposed to extreme stress due to the increasing demand, the introduction of distributed renewable energy sources, and the development of extensive interconnections. We investigate the phenomenon of abrupt breakdown of an electric power-system under two scenarios: load growth (mimicking the ever-increasing customer demand) and power fluctuations (mimicking the effects of renewable sources). Our results on real, realistic and synthetic networks indicate that increasing the system size causes breakdowns to become more abrupt; in fact, mapping the system to a solvable statistical-physics model indicates the occurrence of a first order transition in the large size limit. Such an enhancement for the systemic risk failures (black-outs) with increasing network size is an effect that should be considered in the current projects aiming to integrate national power-grids into "super-grids".

  16. 30 CFR 250.431 - What are the diverter design and installation requirements?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... system; (e) Minimize the number of turns (only one 90-degree turn allowed for each line for bottom-founded drilling units) in the diverter lines, maximize the radius of curvature of turns, and target all right angles and sharp turns; (f) Anchor and support the entire diverter system to prevent whipping...

  17. 30 CFR 250.431 - What are the diverter design and installation requirements?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... system; (e) Minimize the number of turns (only one 90-degree turn allowed for each line for bottom-founded drilling units) in the diverter lines, maximize the radius of curvature of turns, and target all right angles and sharp turns; (f) Anchor and support the entire diverter system to prevent whipping...

  18. 30 CFR 250.431 - What are the diverter design and installation requirements?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... system; (e) Minimize the number of turns (only one 90-degree turn allowed for each line for bottom-founded drilling units) in the diverter lines, maximize the radius of curvature of turns, and target all right angles and sharp turns; (f) Anchor and support the entire diverter system to prevent whipping...

  19. 30 CFR 250.431 - What are the diverter design and installation requirements?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... install manual or butterfly valves in any part of the diverter system; (e) Minimize the number of turns (only one 90-degree turn allowed for each line for bottom-founded drilling units) in the diverter lines, maximize the radius of curvature of turns, and target all right angles and sharp turns; (f) Anchor...

  20. Exhaust gas diverter for divided volute turbocharger of internal combustion engine

    SciTech Connect

    Jain, A.; Meistrick, Z.S.; Pitzi, V.J.

    1992-09-15

    This patent describes a divided volute turbocharger diverter disposed between the exhaust manifold of an internal combustion engine and the turbine of the turbocharger, it comprises: first and second volute passageways; an interconnection passageway interconnecting the first and second volute passageways; an a diverter member disposed in only the first of the first and second volute passageways.

  1. Diverter Decision Aiding for In-Flight Diversions

    NASA Technical Reports Server (NTRS)

    Rudolph, Frederick M.; Homoki, David A.; Sexton, George A.

    1990-01-01

    It was determined that artificial intelligence technology can provide pilots with the help they need in making the complex decisions concerning en route changes in a flight plan. A diverter system should have the capability to take all of the available information and produce a recommendation to the pilot. Phase three illustrated that using Joshua to develop rules for an expert system and a Statice database provided additional flexibility by permitting the development of dynamic weighting of diversion relevant parameters. This increases the fidelity of the AI functions cited as useful in aiding the pilot to perform situational assessment, navigation rerouting, flight planning/replanning, and maneuver execution. Additionally, a prototype pilot-vehicle interface (PVI) was designed providing for the integration of both text and graphical based information. Advanced technologies were applied to PVI design, resulting in a hierarchical menu based architecture to increase the efficiency of information transfer while reducing expected workload. Additional efficiency was gained by integrating spatial and text displays into an integrated user interface.

  2. Moth tails divert bat attack: evolution of acoustic deflection.

    PubMed

    Barber, Jesse R; Leavell, Brian C; Keener, Adam L; Breinholt, Jesse W; Chadwell, Brad A; McClure, Christopher J W; Hill, Geena M; Kawahara, Akito Y

    2015-03-01

    Adaptations to divert the attacks of visually guided predators have evolved repeatedly in animals. Using high-speed infrared videography, we show that luna moths (Actias luna) generate an acoustic diversion with spinning hindwing tails to deflect echolocating bat attacks away from their body and toward these nonessential appendages. We pit luna moths against big brown bats (Eptesicus fuscus) and demonstrate a survival advantage of ∼ 47% for moths with tails versus those that had their tails removed. The benefit of hindwing tails is equivalent to the advantage conferred to moths by bat-detecting ears. Moth tails lured bat attacks to these wing regions during 55% of interactions between bats and intact luna moths. We analyzed flight kinematics of moths with and without hindwing tails and suggest that tails have a minimal role in flight performance. Using a robust phylogeny, we find that long spatulate tails have independently evolved four times in saturniid moths, further supporting the selective advantage of this anti-bat strategy. Diversionary tactics are perhaps more common than appreciated in predator-prey interactions. Our finding suggests that focusing on the sensory ecologies of key predators will reveal such countermeasures in prey.

  3. Using sound to divert fish from turbine intakes

    SciTech Connect

    Loeffelman, P.H.; Hassel, J.H. van ); Klinect, D.A. )

    1991-10-01

    Experiments using underwater sound to deflect fish away from turbine intakes indicate that acoustical signals can potentially make hydroelectric projects more compatible with fish. Four years of development and field tests conducted by the American Electric Power Company, Inc. (AEP), Columbus, Ohio, demonstrated that synthesized low frequency sounds can divert warm and cold freshwater adult and juvenile fish. Test results indicate that underwater sound merits further exploration by the hydropower industry as a possible alternative to physically screening power plant intakes and other mitigation measures. The potential effect on the future of the industry is great, since project compatibility with fish is one constraint limiting development of new hydroelectric facilities, according to the US Department of Energy. In a patented process, AEP used sounds from fish such as chinook salmon, steelhead trout, striped bass, freshwater drum, largemouth bass, and gizzard shad to synthesize signals capable of stimulating fish in the most sensitive portion of their hearing range. The process can create either attracting or repelling sound signals - depending on how the user wants to behaviorally guide the fish. So far, AEP has refined its ability to create repelling sounds, and has customized these signals for single or multiple-target species. Although the hearing range of a few fish species has been determined previously in laboratory tests, the data is not comprehensive and doesn't include hearing ranges of many species at various life stages living near AEP's hydro plants.

  4. Hygienic quality of faeces treated in urine diverting vermicomposting toilets.

    PubMed

    Lalander, Cecilia H; Hill, Geoffrey B; Vinnerås, Björn

    2013-11-01

    On-site sanitation solutions have gained much interest in recent years. One such solution is the urine diverting vermicomposting toilet (UDVT). This study evaluated the hygienic quality of the composted material in six UDVTs in operation in France. Samples were taken from three sampling positions in each toilet, with increasing distance from the fresh material. The concentration of Salmonella spp., Enterococcus spp., thermotolarent coliforms and coliphages were analysed and plotted against a number of variables. The variables found to have the greatest impact was the pH (for Enterococcus spp. and thermotolarent coliforms (TTC)) and time since last maintenance (coliphages). The pH was found to correlate with the material maturity. The current practise of maintenance can cause recontamination of the stabilised material and increase the risk of regrowth of pathogenic microorganisms. A modification in the maintenance procedure, in which a fourth maturation point is introduced, would eliminate this risk. UDVTs were found to be a good on-site sanitation option as the maintenance requirement is small and the system effectively reduced odour and concentration of pathogen and indicator organisms in human waste while keeping the accumulation of material down to a minimum. If the vermicompost is to be used for crops consumed raw, an additional sanitisation step is recommended. PMID:23932466

  5. Preliminary skyshine calculations for the Poloidal Diverter Tokamak Experiment

    SciTech Connect

    Nigg, D.W.; Wheeler, F.J.

    1981-01-01

    The Poloidal Diverter Experiment (PDX) facility at Princeton University is the first operating tokamak to require substantial radiation shielding. A calculational model has been developed to estimate the radiation dose in the PDX control room and at the site boundary due to the skyshine effect. An efficient one-dimensional method is used to compute the neutron and capture gamma leakage currents at the top surface of the PDX roof shield. This method employs an S /SUB n/ calculation in slab geometry and, for the PDX, is superior to spherical models found in the literature. If certain conditions are met, the slab model provides the exact probability of leakage out the top surface of the roof for fusion source neutrons and for capture gamma rays produced in the PDX floor and roof shield. The model also provides the correct neutron and capture gamma leakage current spectra and angular distributions, averaged over the top roof shield surface. For the PDX, this method is nearly as accurate as multidimensional techniques for computing the roof leakage and is much less costly. The actual neutron skyshine dose is computed using a Monte Carlo model with the neutron source at the roof surface obtained from the slab S /SUB n/ calculation. The capture gamma dose is computed using a simple point-kernel single-scatter method.

  6. Diverting Attention Suppresses Human Amygdala Responses to Faces

    PubMed Central

    Morawetz, Carmen; Baudewig, Juergen; Treue, Stefan; Dechent, Peter

    2010-01-01

    Recent neuroimaging studies disagree as to whether the processing of emotion-laden visual stimuli is dependent upon the availability of attentional resources or entirely capacity-free. Two main factors have been proposed to be responsible for the discrepancies: the differences in the perceptual attentional demands of the tasks used to divert attentional resources from emotional stimuli and the spatial location of the affective stimuli in the visual field. To date, no neuroimaging report addressed these two issues in the same set of subjects. Therefore, the aim of the study was to investigate the effects of high and low attentional load as well as different stimulus locations on face processing in the amygdala using functional magnetic resonance imaging to provide further evidence for one of the two opposing theories. We were able for the first time to directly test the interaction of attentional load and spatial location. The results revealed a strong attenuation of amygdala activity when the attentional load was high. The eccentricity of the emotional stimuli did not affect responses in the amygdala and no interaction effect between attentional load and spatial location was found. We conclude that the processing of emotional stimuli in the amygdala is strongly dependent on the availability of attentional resources without a preferred processing of stimuli presented in the periphery and provide firm evidence for the concept of the attentional load theory of emotional processing in the amygdala. PMID:21160563

  7. Moth tails divert bat attack: Evolution of acoustic deflection

    PubMed Central

    Barber, Jesse R.; Leavell, Brian C.; Keener, Adam L.; Breinholt, Jesse W.; Chadwell, Brad A.; McClure, Christopher J. W.; Hill, Geena M.; Kawahara, Akito Y.

    2015-01-01

    Adaptations to divert the attacks of visually guided predators have evolved repeatedly in animals. Using high-speed infrared videography, we show that luna moths (Actias luna) generate an acoustic diversion with spinning hindwing tails to deflect echolocating bat attacks away from their body and toward these nonessential appendages. We pit luna moths against big brown bats (Eptesicus fuscus) and demonstrate a survival advantage of ∼47% for moths with tails versus those that had their tails removed. The benefit of hindwing tails is equivalent to the advantage conferred to moths by bat-detecting ears. Moth tails lured bat attacks to these wing regions during 55% of interactions between bats and intact luna moths. We analyzed flight kinematics of moths with and without hindwing tails and suggest that tails have a minimal role in flight performance. Using a robust phylogeny, we find that long spatulate tails have independently evolved four times in saturniid moths, further supporting the selective advantage of this anti-bat strategy. Diversionary tactics are perhaps more common than appreciated in predator–prey interactions. Our finding suggests that focusing on the sensory ecologies of key predators will reveal such countermeasures in prey. PMID:25730869

  8. Approaching the Edge of Abrupt Climate Change

    NASA Astrophysics Data System (ADS)

    Ramadhin, C.; Yi, C.

    2015-12-01

    The phenomenon of Abrupt Climate Change (ACC) became evident as paleoclimate data analyses began revealing that Earth's climate has the ability to rapidly switch from one state to the next in just a few decades after thresholds are crossed. Previously paleo-climatologists thought these switches were gradual but now there is growing concern to identify thresholds and the dominant feedback mechanisms that propel systems toward thresholds. Current human civilization relies heavily on climate stability and ACC threatens immense disruption with potentially disastrous consequences for all ecosystems. Therefore, prediction of the climate system's approach to threshold values would prove vital for the resilience of civilization through development of appropriate adaptation strategies when that shift occurs. Numerous studies now establish that earth systems are experiencing dramatic changes both by system interactions and anthropogenic sources adding urgency for comprehensive knowledge of tipping point identification. Despite this, predictions are difficult due to the immensity of interactions among feedback mechanisms. In this paper, we attempt to narrow this broad spectrum of critical feedback mechanisms by reviewing several publications on role of feedbacks in initiating past climate transitions establishing the most critical ones and significance in current climate changes. Using a compilation of paleoclimate datasets we compared the rates of deglaciations with that of glacial inceptions, which are approximately 5-10 times slower. We hypothesize that the critical feedbacks are unique to each type of transition such that warmings are dominated by the ice-albedo feedback while coolings are a combination of temperature - CO2 and temperature-precipitation followed by the ice-albedo feedbacks. Additionally, we propose the existence of a commonality in the dominant trigger feedbacks for astronomical and millennial timescale abrupt climate shifts and as such future studies

  9. Bootstrap current for the edge pedestal plasma in a diverted tokamak geometry

    NASA Astrophysics Data System (ADS)

    Koh, S.; Chang, C. S.; Ku, S.; Menard, J. E.; Weitzner, H.; Choe, W.

    2012-07-01

    The edge bootstrap current plays a critical role in the equilibrium and stability of the steep edge pedestal plasma. The pedestal plasma has an unconventional and difficult neoclassical property, as compared with the core plasma. It has a narrow passing particle region in velocity space that can be easily modified or destroyed by Coulomb collisions. At the same time, the edge pedestal plasma has steep pressure and electrostatic potential gradients whose scale-lengths are comparable with the ion banana width, and includes a magnetic separatrix surface, across which the topological properties of the magnetic field and particle orbits change abruptly. A drift-kinetic particle code XGC0, equipped with a mass-momentum-energy conserving collision operator, is used to study the edge bootstrap current in a realistic diverted magnetic field geometry with a self-consistent radial electric field. When the edge electrons are in the weakly collisional banana regime, surprisingly, the present kinetic simulation confirms that the existing analytic expressions [represented by O. Sauter et al., Phys. Plasmas 6, 2834 (1999)] are still valid in this unconventional region, except in a thin radial layer in contact with the magnetic separatrix. The agreement arises from the dominance of the electron contribution to the bootstrap current compared with ion contribution and from a reasonable separation of the trapped-passing dynamics without a strong collisional mixing. However, when the pedestal electrons are in plateau-collisional regime, there is significant deviation of numerical results from the existing analytic formulas, mainly due to large effective collisionality of the passing and the boundary layer trapped particles in edge region. In a conventional aspect ratio tokamak, the edge bootstrap current from kinetic simulation can be significantly less than that from the Sauter formula if the electron collisionality is high. On the other hand, when the aspect ratio is close to unity

  10. Bootstrap current for the edge pedestal plasma in a diverted tokamak geometry

    SciTech Connect

    Koh, S.; Choe, W.; Chang, C. S.; Ku, S.; Menard, J. E.; Weitzner, H.

    2012-07-15

    The edge bootstrap current plays a critical role in the equilibrium and stability of the steep edge pedestal plasma. The pedestal plasma has an unconventional and difficult neoclassical property, as compared with the core plasma. It has a narrow passing particle region in velocity space that can be easily modified or destroyed by Coulomb collisions. At the same time, the edge pedestal plasma has steep pressure and electrostatic potential gradients whose scale-lengths are comparable with the ion banana width, and includes a magnetic separatrix surface, across which the topological properties of the magnetic field and particle orbits change abruptly. A drift-kinetic particle code XGC0, equipped with a mass-momentum-energy conserving collision operator, is used to study the edge bootstrap current in a realistic diverted magnetic field geometry with a self-consistent radial electric field. When the edge electrons are in the weakly collisional banana regime, surprisingly, the present kinetic simulation confirms that the existing analytic expressions [represented by O. Sauter et al., Phys. Plasmas 6, 2834 (1999)] are still valid in this unconventional region, except in a thin radial layer in contact with the magnetic separatrix. The agreement arises from the dominance of the electron contribution to the bootstrap current compared with ion contribution and from a reasonable separation of the trapped-passing dynamics without a strong collisional mixing. However, when the pedestal electrons are in plateau-collisional regime, there is significant deviation of numerical results from the existing analytic formulas, mainly due to large effective collisionality of the passing and the boundary layer trapped particles in edge region. In a conventional aspect ratio tokamak, the edge bootstrap current from kinetic simulation can be significantly less than that from the Sauter formula if the electron collisionality is high. On the other hand, when the aspect ratio is close to unity

  11. Bootstrap Current for the Edge Pedestal Plasma in a Diverted Tokamak Geometry

    SciTech Connect

    Koh, S.; Chang, C. S.; Ku, S.; Menard, J. E.; Weitzner, H.; Choe, W.

    2012-08-10

    The edge bootstrap current plays a critical role in the equilibrium and stability of the steep edge pedestal plasma. The pedestal plasma has an unconventional and difficult neoclassical property, as compared with the core plasma. It has a narrow passing particle region in velocity space that can be easily modified or destroyed by Coulomb collisions. At the same time, the edge pedestal plasma has steep pressure and electrostatic potential gradients whose scale-lengths are comparable with the ion banana width, and includes a magnetic separatrix surface, across which the topological properties of the magnetic field and particle orbits change abruptly. A driftkinetic particle code XGC0, equipped with a mass-momentum-energy conserving collision operator, is used to study the edge bootstrap current in a realistic diverted magnetic field geometry with a self-consistent radial electric field. When the edge electrons are in the weakly collisional banana regime, surprisingly, the present kinetic simulation confirms that the existing analytic expressions [represented by O. Sauter et al. , Phys. Plasmas 6 , 2834 (1999)] are still valid in this unconventional region, except in a thin radial layer in contact with the magnetic separatrix. The agreement arises from the dominance of the electron contribution to the bootstrap current compared with ion contribution and from a reasonable separation of the trapped-passing dynamics without a strong collisional mixing. However, when the pedestal electrons are in plateau-collisional regime, there is significant deviation of numerical results from the existing analytic formulas, mainly due to large effective collisionality of the passing and the boundary layer trapped particles in edge region. In a conventional aspect ratio tokamak, the edge bootstrap current from kinetic simulation can be significantly less than that from the Sauter formula if the electron collisionality is high. On the other hand, when the aspect ratio is close to unity

  12. 76 FR 59664 - Notice of Intent To Prepare an Environmental Impact Statement For Divert Activities and Exercises...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-27

    ... Activities and Exercises, Guam and Commomwealth of The Northern Mariana Islands AGENCY: Headquarters Pacific... Divert Activities and Exercises, Guam and Commonwealth of the Northern Mariana Islands. The proposed divert activities and exercises would involve airfield improvements designed to provide additional...

  13. The Use of Nuclear Explosives To Disrupt or Divert Asteroids

    SciTech Connect

    Dearborn, D S; Patenaude, S; Managan, R A

    2007-02-20

    Nuclear explosives are a mature technology with well-characterized effects. Proposed utilizations include a near asteroid burst to ablate surface material and nudge the body to a safer orbit, or a direct sub-surface burst to fragment the body. For this latter method, previous estimates suggest that for times as short as 1000 days, over 99.999% of the material is diverted, and no longer impacts the Earth, a huge mitigation factor. To better understand these possibilities, we have used a multidimensional radiation/hydrodynamics code to simulate sub-surface and above surface bursts on an inhomogeneous, 1 km diameter body with an average density of 2 g/cc. The body, or fragments (up to 750,000) are then tracked along 4 representative orbits to determine the level of mitigation achieved. While our code has been well tested in simulations on terrestrial structures, the greatest uncertainty in these results lies in the input. These results, particularly the effort to nudge a body into a different orbit, are dependant on NEO material properties, like the dissipation of unconsolidated material in a low gravity environment, as well as the details on an individual body's structure. This problem exists in simulating the effect of any mitigation technology. In addition to providing an greater understanding of the results of applying nuclear explosives to NEO-like bodies, these simulations suggest what must be learned about these bodies to improve the predictive capabilities. Finally, we will comment on some of the popular misinformation abounding about the utility of nuclear explosives.

  14. Abrupt plate accelerations shape rifted continental margins

    NASA Astrophysics Data System (ADS)

    Brune, Sascha; Williams, Simon E.; Butterworth, Nathaniel P.; Müller, R. Dietmar

    2016-08-01

    Rifted margins are formed by persistent stretching of continental lithosphere until breakup is achieved. It is well known that strain-rate-dependent processes control rift evolution, yet quantified extension histories of Earth’s major passive margins have become available only recently. Here we investigate rift kinematics globally by applying a new geotectonic analysis technique to revised global plate reconstructions. We find that rifted margins feature an initial, slow rift phase (less than ten millimetres per year, full rate) and that an abrupt increase of plate divergence introduces a fast rift phase. Plate acceleration takes place before continental rupture and considerable margin area is created during each phase. We reproduce the rapid transition from slow to fast extension using analytical and numerical modelling with constant force boundary conditions. The extension models suggest that the two-phase velocity behaviour is caused by a rift-intrinsic strength–velocity feedback, which can be robustly inferred for diverse lithosphere configurations and rheologies. Our results explain differences between proximal and distal margin areas and demonstrate that abrupt plate acceleration during continental rifting is controlled by the nonlinear decay of the resistive rift strength force. This mechanism provides an explanation for several previously unexplained rapid absolute plate motion changes, offering new insights into the balance of plate driving forces through time.

  15. Abrupt climate-independent fire regime changes

    USGS Publications Warehouse

    Pausas, Juli G.; Keeley, Jon E.

    2014-01-01

    Wildfires have played a determining role in distribution, composition and structure of many ecosystems worldwide and climatic changes are widely considered to be a major driver of future fire regime changes. However, forecasting future climatic change induced impacts on fire regimes will require a clearer understanding of other drivers of abrupt fire regime changes. Here, we focus on evidence from different environmental and temporal settings of fire regimes changes that are not directly attributed to climatic changes. We review key cases of these abrupt fire regime changes at different spatial and temporal scales, including those directly driven (i) by fauna, (ii) by invasive plant species, and (iii) by socio-economic and policy changes. All these drivers might generate non-linear effects of landscape changes in fuel structure; that is, they generate fuel changes that can cross thresholds of landscape continuity, and thus drastically change fire activity. Although climatic changes might contribute to some of these changes, there are also many instances that are not primarily linked to climatic shifts. Understanding the mechanism driving fire regime changes should contribute to our ability to better assess future fire regimes.

  16. Abrupt plate accelerations shape rifted continental margins.

    PubMed

    Brune, Sascha; Williams, Simon E; Butterworth, Nathaniel P; Müller, R Dietmar

    2016-08-11

    Rifted margins are formed by persistent stretching of continental lithosphere until breakup is achieved. It is well known that strain-rate-dependent processes control rift evolution, yet quantified extension histories of Earth's major passive margins have become available only recently. Here we investigate rift kinematics globally by applying a new geotectonic analysis technique to revised global plate reconstructions. We find that rifted margins feature an initial, slow rift phase (less than ten millimetres per year, full rate) and that an abrupt increase of plate divergence introduces a fast rift phase. Plate acceleration takes place before continental rupture and considerable margin area is created during each phase. We reproduce the rapid transition from slow to fast extension using analytical and numerical modelling with constant force boundary conditions. The extension models suggest that the two-phase velocity behaviour is caused by a rift-intrinsic strength--velocity feedback, which can be robustly inferred for diverse lithosphere configurations and rheologies. Our results explain differences between proximal and distal margin areas and demonstrate that abrupt plate acceleration during continental rifting is controlled by the nonlinear decay of the resistive rift strength force. This mechanism provides an explanation for several previously unexplained rapid absolute plate motion changes, offering new insights into the balance of plate driving forces through time.

  17. Abrupt plate accelerations shape rifted continental margins.

    PubMed

    Brune, Sascha; Williams, Simon E; Butterworth, Nathaniel P; Müller, R Dietmar

    2016-08-11

    Rifted margins are formed by persistent stretching of continental lithosphere until breakup is achieved. It is well known that strain-rate-dependent processes control rift evolution, yet quantified extension histories of Earth's major passive margins have become available only recently. Here we investigate rift kinematics globally by applying a new geotectonic analysis technique to revised global plate reconstructions. We find that rifted margins feature an initial, slow rift phase (less than ten millimetres per year, full rate) and that an abrupt increase of plate divergence introduces a fast rift phase. Plate acceleration takes place before continental rupture and considerable margin area is created during each phase. We reproduce the rapid transition from slow to fast extension using analytical and numerical modelling with constant force boundary conditions. The extension models suggest that the two-phase velocity behaviour is caused by a rift-intrinsic strength--velocity feedback, which can be robustly inferred for diverse lithosphere configurations and rheologies. Our results explain differences between proximal and distal margin areas and demonstrate that abrupt plate acceleration during continental rifting is controlled by the nonlinear decay of the resistive rift strength force. This mechanism provides an explanation for several previously unexplained rapid absolute plate motion changes, offering new insights into the balance of plate driving forces through time. PMID:27437571

  18. Economic interpretation of environmental flow regime downstream diverted river reaches.

    NASA Astrophysics Data System (ADS)

    Gorla, Lorenzo; Perona, Paolo

    2013-04-01

    feasible and doesn't imply high costs or advanced management tools. Our approach is a simple but effective step towards eco-sustainability in the growing market of mini hydropower plants, where operation rules like MFR are still widespread. As such, this method is a powerful instrument for political managers to explicit contradictions thus enlightening best compromise measures/decisions. References Perona, P., Characklis, G., Duerrenmatt, D.J., in revision. Inverse parameters estimation of simple riparian benefit economical models. Journal of Environmental Management . Gorla, L. and Perona, P., in revision. On quantifying ecologically sustainable flow releases in a diverted river reach. Journal of Hydrology.

  19. 30 CFR 250.416 - What must I include in the diverter and BOP descriptions?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... outlet internal diameter(s); (3) Diverter-line lengths and diameters; burst strengths and radius of curvature at each turn; and (4) Valve type, size, working pressure rating, and location; (c) A...

  20. 30 CFR 250.416 - What must I include in the diverter and BOP descriptions?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... outlet internal diameter(s); (3) Diverter-line lengths and diameters; burst strengths and radius of curvature at each turn; and (4) Valve type, size, working pressure rating, and location; (c) A...

  1. 30 CFR 250.416 - What must I include in the diverter and BOP descriptions?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... outlet internal diameter(s); (3) Diverter-line lengths and diameters; burst strengths and radius of curvature at each turn; and (4) Valve type, size, working pressure rating, and location; (c) A...

  2. Study of an engine flow diverter system for a large scale ejector powered aircraft model

    NASA Technical Reports Server (NTRS)

    Springer, R. J.; Langley, B.; Plant, T.; Hunter, L.; Brock, O.

    1981-01-01

    Requirements were established for a conceptual design study to analyze and design an engine flow diverter system and to include accommodations for an ejector system in an existing 3/4 scale fighter model equipped with YJ-79 engines. Model constraints were identified and cost-effective limited modification was proposed to accept the ejectors, ducting and flow diverter valves. Complete system performance was calculated and a versatile computer program capable of analyzing any ejector system was developed.

  3. New Variable Porosity Flow Diverter (VPOD) Stent Design for Treatment of Cerebrovascular Aneurysms

    PubMed Central

    Ionita, Ciprian; Baier, Robert; Rudin, Stephen

    2012-01-01

    Using flow diverting Stents for intracranial aneurysm repair has been an area of recent active research. While current commercial flow diverting stents rely on a dense mesh of braided coils for flow diversion, our group has been developing a method to selectively occlude the aneurysm neck, without endangering nearby perforator vessels. In this paper, we present a new method of fabricating the low porosity patch, a key element of such asymmetric vascular stents (AVS). PMID:22254507

  4. Towards Greenland Glaciation: cumulative or abrupt transition?

    NASA Astrophysics Data System (ADS)

    Tan, Ning; Dumas, Christophe; Ladant, Jean-Baptiste; Ramstein, Gilles; Contoux, Camille

    2016-04-01

    During the mid-Pliocene warming period (3-3.3 Ma BP), global annual mean temperature is warmer by 2-3 degree than pre-industrial. Greenland ice sheet volume is supposed to be a 50% reduction compared to nowadays [Haywood et al. 2010]. Around 2.7-2.6 Ma BP, just ~ 500 kyr after the warming peak of mid-Pliocene, there is already full Greenland Glaciation [Lunt et al. 2008]. How does Greenland ice sheet evolve from a half size to a glaciation level during 3 Ma - 2.5 Ma? Data show that there is a decreasing trend of atmospheric CO2 concentration from 3 Ma to 2.5 Ma [Seki et al.2010; Bartoli et al. 2011; Martinez et al. 2015]. However, a recent study [Contoux et al. 2015] suggests that a lowering of CO2 is not sufficient to initiate a perennial glaciation on Greenland and must be combined to low summer insolation, to preserve the ice sheet during insolation maximum, suggesting a cumulative process. In order to diagnose whether the ice sheet build-up is an abrupt event or a cumulative process, we carry on, for the first time, a transient simulation of climate and ice sheet evolutions from 3 Ma to 2.5 Ma. This strategy enables to investigate waxing and waning of the ice sheet during several orbital cycles. To reach this goal, we use a tri-dimensional interpolation method designed by Ladant et al. (2014) which combines the evolution of CO2 concentration, orbital parameters and Greenland ice sheet sizes in an off-line way by interpolating snapshots simulations. Thanks to this new method, we can build a transient like simulation through asynchronous coupling between GCM and ice sheet model. With this method, we may consistently answer the question of the build-up of Greenland: abrupt or cumulative process.

  5. Cesarean Delivery for a Life-threatening Preterm Placental Abruption

    PubMed Central

    Okafor, II; Ugwu, EO

    2015-01-01

    Placental abruption is one of the major life-threatening obstetric conditions. The fetomaternal outcome of a severe placental abruption depends largely on prompt maternal resuscitation and delivery. A case of severe preterm placental abruption with intrauterine fetal death. Following a failed induction of labor with a deteriorating maternal condition despite resuscitation, emergency cesarean delivery was offered with good maternal outcome. Cesarean delivery could avert further disease progression and possible maternal death in cases of severe preterm placental abruption where vaginal delivery is not imminent. However, further studies are necessary before this could be recommended for routine clinical practice. PMID:27057388

  6. The Arctic Grand Challenge: Abrupt Climate Change

    NASA Astrophysics Data System (ADS)

    Wilkniss, P. E.

    2003-12-01

    Trouble in polar paradise (Science, 08/30/02), significant changes in the Arctic environment are scientifically documented (R.E. Moritz et al. ibid.). More trouble, lots more, "abrupt climate change," (R. B. Alley, et al. Science 03/28/03). R. Corell, Arctic Climate Impact Assessment team (ACIA), "If you want to see what will happen in the rest of the world 25 years from now just look what's happening in the Arctic," (Arctic Council meeting, Iceland, 08/03). What to do? Make abrupt Arctic climate change a grand challenge for the IPY-4 and beyond! Scientifically:Describe the "state" of the Arctic climate system as succinctly as possible and accept it as the point of departure.Develop a hypothesis and criteria what constitutes "abrupt climate change," in the Arctic that can be tested with observations. Observations: Bring to bear existing observations and coordinate new investments in observations through an IPY-4 scientific management committee. Make the new Barrow, Alaska, Global Climate Change Research Facility a major U.S. contribution and focal point for the IPY-4 in the U.S Arctic. Arctic populations, Native peoples: The people of the North are living already, daily, with wrenching change, encroaching on their habitats and cultures. For them "the earth is faster now," (I. Krupnik and D. Jolly, ARCUS, 2002). From a political, economic, social and entirely realistic perspective, an Arctic grand challenge without the total integration of the Native peoples in this effort cannot succeed. Therefore: Communications must be established, and the respective Native entities must be approached with the determination to create well founded, well functioning, enduring partnerships. In the U.S. Arctic, Barrow with its long history of involvement and active support of science and with the new global climate change research facility should be the focal point of choice Private industry: Resource extraction in the Arctic followed by oil and gas consumption, return the combustion

  7. Towards Greenland Glaciation: Cumulative or Abrupt Transition?

    NASA Astrophysics Data System (ADS)

    Tan, N.; Ramstein, G.; Contoux, C.; Ladant, J. B.; Dumas, C.; Donnadieu, Y.

    2014-12-01

    The insolation evolution [Laskar 2004] from 4 to 2.5 Ma depicts a series of three summer solstice insolation minima between 2.7 and 2.6 Ma, but there are other more important summer solstice minima notably around 3.82 and 3.05 Ma. On such a time span of more than 1 Ma, data shows that there are variations in the evolution of atmospheric CO2 concentration with a local maximum around 3 Ma [Seki et al.2010; Bartoli et al. 2011], before a decrease between 3 and 2.6 Ma. The latter, suggesting an abrupt ice sheet inception around 2.7 Ma, has been shown to be a major culprit for the full Greenland Glaciation [Lunt et al. 2008]. However, a recent study [Contoux et al. 2014, in review] suggests that a lowering of CO2 is not sufficient to initiate a glaciation on Greenland and must be combined to low summer insolation, with surviving ice during insolation maximum, suggesting a cumulative process in the first place, which could further lead to full glaciation at 2.7 Ma. Through a new tri-dimensional interpolation method implemented within the asynchronous coupling between an atmosphere ocean general circulation model (IPSL-CM5A) and an ice sheet model (GRISLI), we investigate the transient evolution of Greenland ice sheet during the Pliocene to diagnose whether the ice sheet inception is an abrupt event or rather a cumulative process, involving waxing and waning of the ice sheet during several orbital cycles. ReferencesBartoli, G., Hönisch, B., & Zeebe, R. E. (2011). Atmospheric CO2 decline during the Pliocene intensification of Northern Hemisphere glaciations. Paleoceanography, 26(4). Contoux C, Dumas C, Ramstein G, Jost A, Dolan A. M. (2014) Modelling Greenland Ice sheet inception and sustainability during the late Pliocene. (in review for Earth and Planetary Science Letters.).Laskar, J., Robutel, P., Joutel, F., Gastineau, M., Correia, A. C. M., & Levrard, B. (2004). A long-term numerical solution for the insolation quantities of the Earth. Astronomy & Astrophysics, 428

  8. Restrictive cardiomyopathy

    MedlinePlus

    Cardiomyopathy - restrictive; Infiltrative cardiomyopathy; Idiopathic myocardial fibrosis ... of the heart lining (endocardium), such as endomyocardial fibrosis and Loeffler syndrome (rare) Iron overload (hemochromatosis) Sarcoidosis ...

  9. Going, Going, Gone: Localizing Abrupt Offsets of Moving Objects

    ERIC Educational Resources Information Center

    Maus, Gerrit W.; Nijhawan, Romi

    2009-01-01

    When a moving object abruptly disappears, this profoundly influences its localization by the visual system. In Experiment 1, 2 aligned objects moved across the screen, and 1 of them abruptly disappeared. Observers reported seeing the objects misaligned at the time of the offset, with the continuing object leading. Experiment 2 showed that the…

  10. Initial experience with implantation of novel dual layer flow-diverter device FRED

    PubMed Central

    Sagan, Leszek; Safranow, Krzysztof; Rać, Monika

    2013-01-01

    Flow-diverting stents can help treat complex and wide-necked cerebral aneurysms. The aim of the study was to evaluate initial experiences related to the safety and effectiveness of eight aneurysms treated with a new dual layer coverage designed flow-diverter device. In 2012 Fred flow-diverter devices were used to treat 8 unruptured wide neck (dome-neck ratio ≤ 1.5) and sidewall aneurysms in 6 patients. All aneurysms were located in the anterior circulation on the internal carotid artery (ICA). In 4 larger aneurysms (> 10 mm) one 3D coil in association with Fred was used to reduce potential incidence of postoperative subarachnoid haemorrhage (SAH). Dual antiplatelet therapy was administered before the procedure and continued for 3 months after it. Clinical parameters, aneurysm features and 3-month follow-up angiograms are presented. All 6 patients with 8 aneurysms were successfully stented with the Fred flow-diverter device and were discharged in generally good condition on dual-antiplatelet therapy. No complications were related to the procedure. In 5 cases digital subtraction angiography (DSA) control examination was performed after 3 months, showing complete occlusion of the aneurysms with patency of the parent artery. In 1 case thrombosis of the Fred occurred but without any clinical consequences because of cross-flow from the other side. Use of the Fred flow-diverter device was efficacious in all 8 treated cerebral aneurysms. The system seems to be promising as a flow diverter with certain characteristics, which allow for easy delivery and implantation. Further clinical evaluation with a larger group of patients is needed. PMID:24130644

  11. Tipping Elements in Earth Systems Special Feature: Basic mechanism for abrupt monsoon transitions

    NASA Astrophysics Data System (ADS)

    Levermann, Anders; Schewe, Jacob; Petoukhov, Vladimir; Held, Hermann

    2009-12-01

    Monsoon systems influence the livelihood of hundreds of millions of people. During the Holocene and last glacial period, rainfall in India and China has undergone strong and abrupt changes. Though details of monsoon circulations are complicated, observations reveal a defining moisture-advection feedback that dominates the seasonal heat balance and might act as an internal amplifier, leading to abrupt changes in response to relatively weak external perturbations. Here we present a minimal conceptual model capturing this positive feedback. The basic equations, motivated by observed relations, yield a threshold behavior, robust with respect to addition of other physical processes. Below this threshold in net radiative influx, R c, no conventional monsoon can develop; above R c, two stable regimes exist. We identify a nondimensional parameter l that defines the threshold and makes monsoon systems comparable with respect to the character of their abrupt transition. This dynamic similitude may be helpful in understanding past and future variations in monsoon circulation. Within the restrictions of the model, we compute R c for current monsoon systems in India, China, the Bay of Bengal, West Africa, North America, and Australia, where moisture advection is the main driver of the circulation.

  12. Low or Ultralow Anterior Resection of Rectal Cancer Without Diverting Stoma: Experience with 28 Patients.

    PubMed

    Soltani, E; Jangjoo, A; Saremi, E

    2015-12-01

    A diverting temporary stoma is frequently used to decrease the chance of anastomosis leakage in the middle and lower rectum cancer surgeries, but its role in preventing the leakage is still doubtful. This study has been designed to evaluate any possible anastomosis complications after a rectum resection and a low or ultralow anastomosis when no diverting stoma is applied in patients with rectal cancer. Twenty-eight patients suffering from rectal cancer were treated by a low anterior resection between the years 2005 and 2008 in Imam Reza University Hospital, Mashhad, Iran. Out of the 28 patients, 6 patients had already undergone a course of neoadjuvant radiotherapy. Anastomosis was performed manually in 23 patients, using a stapler in 5 of them. None of the patients had a diverting stoma. Then, the outcome was evaluated. Fecal incontinence occurred in one of the patients (6.7 %) who had already undergone a course of radiotherapy preoperatively and had a stapler used for anastomosis. No leakage was detected in any of them. The very low incidence of complications in this study, such as those not preventable by a diverting stoma, suggest a very low chance of leakage in low or ultralow anastomosis in patients with rectal cancer and in those who were treated with neoadjuvant radiotherapy. PMID:26730038

  13. Characteristics of Adolescents and Young Adults with ADHD Who Divert or Misuse Their Prescribed Medications

    ERIC Educational Resources Information Center

    Wilens, Timothy E.; Gignac, Martin; Swezey, Allison; Monuteaux, Michael C.; Biederman, Joseph

    2006-01-01

    Objective: Little is known about the risks and characteristics of attention-deficit/hyperactivity disorder (ADHD) patients who misuse or divert their stimulant medications. As part of a 10-year longitudinal study of youths with ADHD, the authors evaluated medication diversion or misuse at the last follow-up period. Method: Structured psychiatric…

  14. 30 CFR 250.416 - What must I include in the diverter and BOP descriptions?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Drilling Operations Applying for A Permit to Drill § 250.416 What must I include in the diverter and BOP descriptions? You must... rams installed in the BOP stack (both surface and subsea stacks) are capable of shearing the drill...

  15. Design and mechanical properties of a novel cerebral flow diverter stent.

    PubMed

    Ma, Jiayao; You, Zhong; Byrne, James; Rizkallah, Rafik R

    2014-05-01

    Brain arterial aneurysms are localised dilatation in the wall of cerebral arteries that are common among adult population and associated with high incidence of morbidity and mortality. Using flow diverter stent alone to treat cerebral aneurysm is recognized as a safe and effective method. However, flow diverter stents currently available have limitations due to their braided structures. In this paper a novel flow diverter stent is proposed. It is made out of nitinol tubes that provide adequate radial stiffness and tailored surface coverage to overcome problems of currently available braided stents while retaining low porosity and excellent longitudinal flexibility. Finite element analysis using Abaqus has been conducted to investigate radial stiffness, longitudinal flexibility, and maximum strain during packaging of a series of novel stent designs with varied geometric parameters. Results show that porosity below 70% can be achieved and provides radial stiffness and longitudinal flexibility comparable to those of the Neuroform stent that is commonly used for stent assisted coiling. The novel flow diverter has showed great potential for direct treatment of cerebral aneurysms. PMID:24449051

  16. Abrupt climate change in the computer: Is it real?

    PubMed Central

    Stocker, Thomas F.; Marchal, Olivier

    2000-01-01

    Models suggest that dramatic changes in the ocean circulation are responsible for abrupt climate changes during the last ice age and may possibly alter the relative climate stability of the last 10,000 years. PMID:10677468

  17. The Role of the Tropics in Abrupt Climate Changes

    SciTech Connect

    Fedorov, Alexey

    2013-12-07

    Topics addressed include: abrupt climate changes and ocean circulation in the tropics; what controls the ocean thermal structure in the tropics; a permanent El Niño in paleoclimates; the energetics of the tropical ocean.

  18. Status Cataplecticus Precipitated by Abrupt Withdrawal of Venlafaxine

    PubMed Central

    Wang, Janice; Greenberg, Harly

    2013-01-01

    Status cataplecticus is a rare manifestation of narcolepsy with cataplexy episodes recurring for hours or days, without a refractory period, in the absence of emotional triggers. This case highlights a narcoleptic patient who developed status cataplecticus after abrupt withdrawal of venlafaxine. Citation: Wang J; Greenberg H. Status cataplecticus precipitated by abrupt withdrawal of venlafaxine. J Clin Sleep Med 2013;9(7):715-716. PMID:23853567

  19. An automatic CFD-based flow diverter optimization principle for patient-specific intracranial aneurysms.

    PubMed

    Janiga, Gábor; Daróczy, László; Berg, Philipp; Thévenin, Dominique; Skalej, Martin; Beuing, Oliver

    2015-11-01

    The optimal treatment of intracranial aneurysms using flow diverting devices is a fundamental issue for neuroradiologists as well as neurosurgeons. Due to highly irregular manifold aneurysm shapes and locations, the choice of the stent and the patient-specific deployment strategy can be a very difficult decision. To support the therapy planning, a new method is introduced that combines a three-dimensional CFD-based optimization with a realistic deployment of a virtual flow diverting stent for a given aneurysm. To demonstrate the feasibility of this method, it was applied to a patient-specific intracranial giant aneurysm that was successfully treated using a commercial flow diverter. Eight treatment scenarios with different local compressions were considered in a fully automated simulation loop. The impact on the corresponding blood flow behavior was evaluated qualitatively as well as quantitatively, and the optimal configuration for this specific case was identified. The virtual deployment of an uncompressed flow diverter reduced the inflow into the aneurysm by 24.4% compared to the untreated case. Depending on the positioning of the local stent compression below the ostium, blood flow reduction could vary between 27.3% and 33.4%. Therefore, a broad range of potential treatment outcomes was identified, illustrating the variability of a given flow diverter deployment in general. This method represents a proof of concept to automatically identify the optimal treatment for a patient in a virtual study under certain assumptions. Hence, it contributes to the improvement of virtual stenting for intracranial aneurysms and can support physicians during therapy planning in the future.

  20. Hybrid stent device of flow-diverting effect and stent-assisted coil embolization formed by fractal structure.

    PubMed

    Kojima, Masahiro; Irie, Keiko; Masunaga, Kouhei; Sakai, Yasuhiko; Nakajima, Masahiro; Takeuchi, Masaru; Fukuda, Toshio; Arai, Fumihito; Negoro, Makoto

    2016-05-01

    This paper presents a novel hybrid medical stent device. This hybrid stent device formed by fractal mesh structures provides a flow-diverting effect and stent-assisted coil embolization. Flow-diverter stents decrease blood flow into an aneurysm to prevent its rupture. In general, the mesh size of a flow-diverter stent needs to be small enough to prevent blood flow into the aneurysm. Conventional flow-diverter stents are not available for stent-assisted coil embolization, which is an effective method for aneurysm occlusion, because the mesh size is too small to insert a micro-catheter for coil embolization. The proposed hybrid stent device is capable of stent-assisted coil embolization while simultaneously providing a flow-diverting effect. The fractal stent device is composed of mesh structures with fine and rough mesh areas. The rough mesh area can be used to insert a micro-catheter for stent-assisted coil embolization. Flow-diverting effects of two fractal stent designs were composed to three commercially available stent designs. Flow-diverting effects were analyzed using computational fluid dynamics (CFD) analysis and particle image velocimetry (PIV) experiment. Based on the CFD and PIV results, the fractal stent devices reduce the flow velocity inside an aneurism just as much as the commercially available flow-diverting stents while allowing stent-assisted coil embolization. PMID:26438390

  1. Hybrid stent device of flow-diverting effect and stent-assisted coil embolization formed by fractal structure.

    PubMed

    Kojima, Masahiro; Irie, Keiko; Masunaga, Kouhei; Sakai, Yasuhiko; Nakajima, Masahiro; Takeuchi, Masaru; Fukuda, Toshio; Arai, Fumihito; Negoro, Makoto

    2016-05-01

    This paper presents a novel hybrid medical stent device. This hybrid stent device formed by fractal mesh structures provides a flow-diverting effect and stent-assisted coil embolization. Flow-diverter stents decrease blood flow into an aneurysm to prevent its rupture. In general, the mesh size of a flow-diverter stent needs to be small enough to prevent blood flow into the aneurysm. Conventional flow-diverter stents are not available for stent-assisted coil embolization, which is an effective method for aneurysm occlusion, because the mesh size is too small to insert a micro-catheter for coil embolization. The proposed hybrid stent device is capable of stent-assisted coil embolization while simultaneously providing a flow-diverting effect. The fractal stent device is composed of mesh structures with fine and rough mesh areas. The rough mesh area can be used to insert a micro-catheter for stent-assisted coil embolization. Flow-diverting effects of two fractal stent designs were composed to three commercially available stent designs. Flow-diverting effects were analyzed using computational fluid dynamics (CFD) analysis and particle image velocimetry (PIV) experiment. Based on the CFD and PIV results, the fractal stent devices reduce the flow velocity inside an aneurism just as much as the commercially available flow-diverting stents while allowing stent-assisted coil embolization.

  2. Trash Diverter Orientation Angle Optimization at Run-Off River Type Hydro-power Plant using CFD

    NASA Astrophysics Data System (ADS)

    Munisamy, Kannan M.; Kamal, Ahmad; Shuaib, Norshah Hafeez; Yusoff, Mohd. Zamri; Hasini, Hasril; Rashid, Azri Zainol; Thangaraju, Savithry K.; Hamid, Hazha

    2010-06-01

    Tenom Pangi Hydro Power Station in Tenom, Sabah is suffering from poor river quality with a lot of suspended trashes. This problem necessitates the need for a trash diverter to divert the trash away from the intake region. Previously, a trash diverter (called Trash Diverter I) was installed at the site but managed to survived for a short period of time due to an impact with huge log as a results of a heavy flood. In the current project, a second trash diverter structure is designed (called Trash Diverter II) with improved features compared to Trash Diverter I. The Computational Fluid Dynamics (CFD) analysis is done to evaluate the river flow interaction onto the trash diverter from the fluid flow point of view, Computational Fluids Dynamics is a numerical approach to solve fluid flow profile for different inlet conditions. In this work, the river geometry is modeled using commercial CFD code, FLUENT®. The computational model consists of Reynolds Averaged Navier-Stokes (RANS) equations coupled with other related models using the properties of the fluids under investigation. The model is validated with site-measurements done at Tenom Pangi Hydro Power Station. Different operating condition of river flow rate and weir opening is also considered. The optimum angle is determined in this simulation to further use the data for 3D simulation and structural analysis.

  3. Morphologic and Clinical Outcome of Intracranial Aneurysms after Treatment Using Flow Diverter Devices: Mid-Term Follow-Up

    PubMed Central

    Breu, Anna-Katharina; Hauser, Till-Karsten; Ebner, Florian H.; Bischof, Felix; Ernemann, Ulrike; Seeger, Achim

    2016-01-01

    Flow diverters (FDs) are designed for the endovascular treatment of complex intracranial aneurysm configurations. From February 2009 to March 2013 28 patients (22 females, 6 males) were treated with FD; mean age was 57 years. Data, including aneurysm features, clinical presentation, history of previous bleeding, treatment, and follow-up results, are presented. Early postinterventional neurological deficits (transient: n = 3/enduring: n = 1) appeared in 4/28 patients (14%), and early improvement of neurological symptoms was observed in 7 patients with previous restriction of cranial nerve function. The overall occlusion rate was 20/26 (77%; 59% after 3 months). 77% achieved best results according to O'Kelly-Marotta score grade D with no contrast material filling (70% of those after 3 months). In 4/6 patients who did not achieve grade D, proximal and/or distal stent overlapping ≥5 mm was not guaranteed sufficiently. During follow-up we did not detect any aneurysm recurrence or haemorrhage. In-stent stenosis emerged as the most frequent complication (4/27; 15%) followed by 2 cases of vascular obliteration (AICA/VA). In conclusion endovascular reconstruction using a FD represents a modern and effective treatment in those aneurysms that are not suitable for conventional interventional or surgical treatment. The appearance of severe complications was rare. PMID:27006830

  4. Abrupt changes in rainfall during the twentieth century

    NASA Astrophysics Data System (ADS)

    Narisma, G.; Foley, J.; Licker, R.; Ramankutty, N.

    2007-12-01

    A sudden change in climate is brought about by complex interactions in the climate system, including interactions between land and atmosphere, that can give rise to strong positive feedback mechanisms. Paleoclimatic studies have shown that abrupt climate changes have happened in the geologic past. Studies of future climate change under global warming scenarios indicate the possibility of the sudden collapse of the thermohaline circulation, which will have major implications for the climate of Europe. However, abrupt climatic changes are not events of the geologic past or a computer-simulated future: they have occurred in recent history and have had serious consequences on society and the environment. The prolonged Sahel drought in the late 1960s and the Dust Bowl of the 1930s are examples of abrupt climatic changes of the twentieth century. Apart from these events, however, there has been no systematic survey of recent climate history to determine the prevalence of abrupt climatic changes. Given the potential cost of these abrupt changes, there is a need to investigate historical records for evidence of other sudden climatic changes in the more recent past. Here we analyze the Climate Research Unit global historical rainfall observations (covering the years 1901-2000) using wavelet analysis to detect regions that have undergone large, sudden decreases in rainfall. We show that in the twentieth century, aside from the Sahel and the US midwest, at least 30 regions in the world have experienced sudden climatic changes. These events are statistically significant at the 99 percent level, are persistent for at least ten years, and most have magnitudes of change that are 10 percent lower than the climatological normal (1901-2000 rainfall average). We also illustrate some of the potential consequences of these abrupt changes and show that these events had major impacts on social and environmental conditions. Interestingly, these regions of abrupt precipitation changes are

  5. Abrupt seasonal variation of the ITCZ and the Hadley circulation

    NASA Astrophysics Data System (ADS)

    Hu, Yongyun; Li, Dawei; Liu, Jiping

    2007-09-01

    Using Global Precipitation Climatology Project (GPCP) daily data, we show that the seasonal migration of the global zonal-mean intertropical convergence zone (ITCZ) is not smooth, but jumps from the winter hemisphere to the summer hemisphere. The abrupt migration is within 10 days. Detailed analyses reveal that the phenomenon of the abrupt seasonal migration of the ITCZ mainly exists over particular tropical domains, such as Indian Ocean, western and central Pacific, and South America, which gives the rise of the jump of the global zonal-mean ITCZ. Because the ITCZ constitutes the ascending branch of the Hadley circulation, we also examine whether there exists such an abrupt seasonal change in the Hadley circulation. It is found that the intensity of the Hadley cells evolves smoothly with time. However, the horizontal scales of the Hadley cells demonstrate abrupt seasonal changes, corresponding to the abrupt seasonal migration of the global ITCZ. The winter cell extends rapidly across the equator, while the summer cell rapidly narrows. This suggests that the solsticial cell is the dominant component of the Hadley circulation, and that the equinoctial symmetric pattern is ephemeral.

  6. Numerical Studies of a Supersonic Fluidic Diverter Actuator for Flow Control

    NASA Technical Reports Server (NTRS)

    Gokoglu, Suleyman A.; Kuczmarski, Maria A.; Culley, Dennis e.; Raghu, Surya

    2010-01-01

    The analysis of the internal flow structure and performance of a specific fluidic diverter actuator, previously studied by time-dependent numerical computations for subsonic flow, is extended to include operation with supersonic actuator exit velocities. The understanding will aid in the development of fluidic diverters with minimum pressure losses and advanced designs of flow control actuators. The self-induced oscillatory behavior of the flow is successfully predicted and the calculated oscillation frequencies with respect to flow rate have excellent agreement with our experimental measurements. The oscillation frequency increases with Mach number, but its dependence on flow rate changes from subsonic to transonic to supersonic regimes. The delay time for the initiation of oscillations depends on the flow rate and the acoustic speed in the gaseous medium for subsonic flow, but is unaffected by the flow rate for supersonic conditions

  7. Strategy for analysis of flow diverting devices based on multi-modality image-based modeling

    PubMed Central

    Cebral, Juan R.; Mut, Fernando; Raschi, Marcelo; Ding, Yong-Hong; Kadirvel, Ramanathan; Kallmes, David

    2014-01-01

    Quantification and characterization of the hemodynamic environment created after flow diversion treatment of cerebral aneurysms is important to understand the effects of flow diverters and their interactions with the biology of the aneurysm wall and the thrombosis process that takes place subsequently. This paper describes the construction of multi-modality image-based subject-specific CFD models of experimentally created aneurysms in rabbits and subsequently treated with flow diverters. Briefly, anatomical models were constructed from 3D rotational angiography images, flow conditions were derived from Doppler ultrasound measurements, stent models were created and virtually deployed, and the results were compared to in vivo digital subtraction angiography and Doppler ultrasound images. The models were capable of reproducing in vivo observations, including velocity waveforms measured in the parent artery, peak velocity values measured in the aneurysm, and flow structures observed with digital subtraction angiography before and after deployment of flow diverters. The results indicate that regions of aneurysm occlusion after flow diversion coincide with slow and smooth flow patterns, while regions still permeable at the time of animal sacrifice were observed in parts of the aneurysm exposed to larger flow activity, i.e. higher velocities, more swirling and more complex flow structures. PMID:24719392

  8. MODELING OF STOCHASTIC MAGNETIC FLUX LOSS FROM THE EDGE OF A POOIDALLY DIVERTED TOKAMAK

    SciTech Connect

    EVANS, TE,; MOYER, RA; MONAT, P

    2002-06-01

    OAK A271 MODELING OF STOCHASTIC MAGNETIC FLUX LOSS FROM THE EDGE OF A POOIDALLY DIVERTED TOKAMAK. A field line integration code is used to study the loss of edge poloidal magnetic flux due to stochastic magnetic fields produced by an error field correction coil (C-coil) in DIII-D for various plasma shapes, coil currents and edge magnetic shear profiles. The authors find that the boundary of a diverted tokamak is more sensitive to stochastic flux loss than a nondiverted tokamak. The C-coil has been used to produce a stochastic layer in an ohmic diverted discharge with characteristics similar to those seen in stochastic boundary experiments in circular limiter ohmic plasmas, including: (1) an overall increase in recycling, (2) a broadening of the recycling profile at the divertor, and (3) a flattening of the boundary profiles over the extent of the stochastic layer predicted by the field line integration code. Profile flattening consistent with field line integration results is also seen in some high performance discharges with edge transport barriers. The prediction of a significant edge stochastic layer even in discharges with high performance and edge radial transport barriers indicates that either the self-consistent plasma response heals the stochastic layer or that edge stochastic layers are compatible with edge radial transport barriers.

  9. Nacelle/Diverter Integration into the Design Optimization Process Using Pseudo, Warped, and Real Nacelles

    NASA Technical Reports Server (NTRS)

    Cliff, Susan E.; Reuther, James J.; Saunders, David A.; Rimlinger, Mark J.

    1999-01-01

    The computational results of the optimized complete configurations, including nacelles and diverters, are presented in terms of drag count improvement compared with the TCA baseline configuration at Mach 2.4, C(sub L)=0.1. The three candidate designs are designated by the organization from which they were derived. ARC represents the Ames Research Center 1-03 design, BCAG represents the Boeing Commercial Aircraft Group's design from Seattle, and BLB represents the design from Boeing Long Beach. All CFD methods are in unanimous agreement that the Ames 1-03 configuration has the largest performance improvement, followed closely by the BCAG configuration, with a much smaller improvement attained by Boeing Long Beach. The Ames design was obtained using the single-block wing/body code SYN87-SB with its "pseudo" nacelle option-an elaborate technique for incorporating nacelle/diverter effects into the design optimization process. This technique uses AIRPLANE surface pressure coefficient data with and without the nacelles/diverters. Further details of this method are described. It is reasonable to expect that further improvements could be achieved by including the "real" nacelles directly into the optimization process by use of the newly-developed multiblock optimization code, SYN107-MB, which can handle full configurations.

  10. Strategy for analysis of flow diverting devices based on multi-modality image-based modeling.

    PubMed

    Cebral, Juan R; Mut, Fernando; Raschi, Marcelo; Ding, Yong-Hong; Kadirvel, Ramanathan; Kallmes, David

    2014-10-01

    Quantification and characterization of the hemodynamic environment created after flow diversion treatment of cerebral aneurysms is important to understand the effects of flow diverters and their interactions with the biology of the aneurysm wall and the thrombosis process that takes place subsequently. This paper describes the construction of multi-modality image-based subject-specific CFD models of experimentally created aneurysms in rabbits and subsequently treated with flow diverters. Briefly, anatomical models were constructed from 3D rotational angiography images, flow conditions were derived from Doppler ultrasound measurements, stent models were created and virtually deployed, and the results were compared with in vivo digital subtraction angiography and Doppler ultrasound images. The models were capable of reproducing in vivo observations, including velocity waveforms measured in the parent artery, peak velocity values measured in the aneurysm, and flow structures observed with digital subtraction angiography before and after deployment of flow diverters. The results indicate that regions of aneurysm occlusion after flow diversion coincide with slow and smooth flow patterns, whereas regions still permeable at the time of animal sacrifice were observed in parts of the aneurysm exposed to larger flow activity, that is, higher velocities, more swirling, and more complex flow structures. PMID:24719392

  11. Uses of diverted methadone and buprenorphine by opioid-addicted individuals in Baltimore, Maryland

    PubMed Central

    Mitchell, Shannon Gwin; Kelly, Sharon M.; Brown, Barry S.; Reisinger, Heather Schacht; Peterson, James A.; Ruhf, Adrienne; Agar, Michael H.; O'Grady, Kevin E.; Schwartz, Robert P.

    2009-01-01

    This study examined the uses of diverted methadone and buprenorphine among opiate-addicted individuals recruited from new admissions to methadone programs and from out-of-treatment individuals recruited from the streets. Self-report data regarding diversion were obtained from surveys and semi-structured qualitative interviews. Approximately 16% (n=84) of the total sample (N=515) reported using diverted (street) methadone 2–3 times per week for six months or more, and for an average of 7.8 days (SD=10.3) within the past month. The group reporting lifetime use of diverted methadone as compared to the group that did not report such use was less likely to use heroin and cocaine in the 30 days prior to admission (ps < .01) and had lower ASI Drug Composite scores (p < .05). Participants in our qualitative sub-sample (n=22) indicated that street methadone was more widely used than street buprenorphine and that both drugs were largely used as self-medication for detoxification and withdrawal symptoms. Participants reported using low dosages and no injection of either medication was reported. PMID:19874152

  12. International policy implications of abrupt climate change scenarios

    SciTech Connect

    Molitor, M.R.

    1997-12-31

    New theoretical and empirical evidence supports the view that in the recent past [Holocene] abrupt climate changes occurred over very short [decadal] time periods. One leading possibility of future changes involves the North Atlantic Ocean conveyor that transfers warm surface waters from the equator to northern latitudes and helps maintain Europe`s climate. The predicted abrupt climate change scenario theorizes that the conveyor may be modified as a result of disruption of the thermohaline circulation driving North, Atlantic Deep Water. This would lead, the theory contends, to a rapid cooling of Europe`s climate. In light of the EPCC`s 1995 Second Assessment Report conclusion that there is a {open_quotes}discernible{close_quotes} human influence on the global climate system, there are many emerging questions concerning possible abrupt climate change scenarios.

  13. Sea-ice switches and abrupt climate change.

    PubMed

    Gildor, Hezi; Tziperman, Eli

    2003-09-15

    We propose that past abrupt climate changes were probably a result of rapid and extensive variations in sea-ice cover. We explain why this seems a perhaps more likely explanation than a purely thermohaline circulation mechanism. We emphasize that because of the significant influence of sea ice on the climate system, it seems that high priority should be given to developing ways for reconstructing high-resolution (in space and time) sea-ice extent for past climate-change events. If proxy data can confirm that sea ice was indeed the major player in past abrupt climate-change events, it seems less likely that such dramatic abrupt changes will occur due to global warming, when extensive sea-ice cover will not be present.

  14. Sea-ice switches and abrupt climate change.

    PubMed

    Gildor, Hezi; Tziperman, Eli

    2003-09-15

    We propose that past abrupt climate changes were probably a result of rapid and extensive variations in sea-ice cover. We explain why this seems a perhaps more likely explanation than a purely thermohaline circulation mechanism. We emphasize that because of the significant influence of sea ice on the climate system, it seems that high priority should be given to developing ways for reconstructing high-resolution (in space and time) sea-ice extent for past climate-change events. If proxy data can confirm that sea ice was indeed the major player in past abrupt climate-change events, it seems less likely that such dramatic abrupt changes will occur due to global warming, when extensive sea-ice cover will not be present. PMID:14558902

  15. Abrupt Depletion Layer Approximation for the Metal Insulator Semiconductor Diode.

    ERIC Educational Resources Information Center

    Jones, Kenneth

    1979-01-01

    Determines the excess surface change carrier density, surface potential, and relative capacitance of a metal insulator semiconductor diode as a function of the gate voltage, using the precise questions and the equations derived with the abrupt depletion layer approximation. (Author/GA)

  16. Abrupt climate change and thermohaline circulation: mechanisms and predictability.

    PubMed

    Marotzke, J

    2000-02-15

    The ocean's thermohaline circulation has long been recognized as potentially unstable and has consequently been invoked as a potential cause of abrupt climate change on all timescales of decades and longer. However, fundamental aspects of thermohaline circulation changes remain poorly understood.

  17. Abrupt changes in the dynamics of quantum disentanglement

    SciTech Connect

    Lastra, F.; Romero, G.; Lopez, C. E.; Retamal, J. C.; Franca Santos, M.

    2007-06-15

    The evolution of the lower bound of entanglement proposed by Chen et al. [Phys. Rev. Lett. 95, 210501 (2005)] in high-dimensional bipartite systems under dissipation is studied. Discontinuities for the time derivative of this bound are found depending on the initial conditions for entangled states. These abrupt changes along the evolution of the entanglement bound appear as precursors of sudden death.

  18. Abrupt climate change and thermohaline circulation: mechanisms and predictability.

    PubMed

    Marotzke, J

    2000-02-15

    The ocean's thermohaline circulation has long been recognized as potentially unstable and has consequently been invoked as a potential cause of abrupt climate change on all timescales of decades and longer. However, fundamental aspects of thermohaline circulation changes remain poorly understood. PMID:10677464

  19. Mechanisms of abrupt climate change of the last glacial period

    NASA Astrophysics Data System (ADS)

    Clement, Amy C.; Peterson, Larry C.

    2008-12-01

    More than a decade ago, ice core records from Greenland revealed that the last glacial period was characterized by abrupt climate changes that recurred on millennial time scales. Since their discovery, there has been a large effort to determine whether these climate events were a global phenomenon or were just confined to the North Atlantic region and also to reveal the mechanisms that were responsible for them. In this paper, we review the available paleoclimate observations of abrupt change during the last glacial period in order to place constraints on possible mechanisms. Three different mechanisms are then reviewed: ocean thermohaline circulation, sea ice feedbacks, and tropical processes. Each mechanism is tested for its ability to explain the key features of the observations, particularly with regard to the abruptness, millennial recurrence, and geographical extent of the observed changes. It is found that each of these mechanisms has explanatory strengths and weaknesses, and key areas in which progress could be made in improving the understanding of their long-term behavior, both from observational and modeling approaches, are suggested. Finally, it is proposed that a complete understanding of the mechanisms of abrupt change requires inclusion of processes at both low and high latitudes, as well as the potential for feedbacks between them. Some suggestions for experimental approaches to test for such feedbacks with coupled climate models are given.

  20. Delayed complications after flow-diverter stenting: reactive in-stent stenosis and creeping stents.

    PubMed

    Cohen, José E; Gomori, John Moshe; Moscovici, Samuel; Leker, Ronen R; Itshayek, Eyal

    2014-07-01

    We assessed the frequency and severity of changes in stent configuration and location after the treatment of intracranial aneurysms, and patterns of in-stent stenosis. We retrospectively reviewed data for consecutive aneurysm patients managed with endovascular implantation of flow-diverter stents (Silk Flow Diverter [Balt Extrusion, Montmorency, France] and Pipeline Embolization Device [ev3/Coviden, Minneapolis, MN, USA]) from October 2011 to July 2012. Routine 2, 6, 9-12, and 16-20 month follow-up angiograms were compared, with a focus on changes in stent configuration and location from immediately after deployment to angiographic follow-up, and the incidence and development of in-stent stenosis. Thirty-four patients with 42 aneurysms met inclusion criteria. The Silk device was implanted in 16 patients (47%, single device in 15), the Pipeline device in 18 (53%, single device in 16). On first follow-up angiography, in-stent stenosis was observed in 38% of Silk devices and 39% of Pipeline devices. In-stent stenosis was asymptomatic in 12 of 13 patients. One woman presented with transient ischemic attacks and required stent angioplasty due to end tapering and mild, diffuse in-stent stenosis. Configuration and location changes, including stent creeping and end tapering were seen in 2/16 patients (13%) with Silk devices, and 0/18 patients with Pipeline devices. We describe stent creeping and end tapering as unusual findings with the potential for delayed clinical complications. In-stent stenosis, with a unique behavior, is a frequent angiographic finding observed after flow-diverter stent implant. The stenosis is usually asymptomatic; however, close clinical and angiographic monitoring is mandatory for individualized management. PMID:24524952

  1. Delayed complications after flow-diverter stenting: reactive in-stent stenosis and creeping stents.

    PubMed

    Cohen, José E; Gomori, John Moshe; Moscovici, Samuel; Leker, Ronen R; Itshayek, Eyal

    2014-07-01

    We assessed the frequency and severity of changes in stent configuration and location after the treatment of intracranial aneurysms, and patterns of in-stent stenosis. We retrospectively reviewed data for consecutive aneurysm patients managed with endovascular implantation of flow-diverter stents (Silk Flow Diverter [Balt Extrusion, Montmorency, France] and Pipeline Embolization Device [ev3/Coviden, Minneapolis, MN, USA]) from October 2011 to July 2012. Routine 2, 6, 9-12, and 16-20 month follow-up angiograms were compared, with a focus on changes in stent configuration and location from immediately after deployment to angiographic follow-up, and the incidence and development of in-stent stenosis. Thirty-four patients with 42 aneurysms met inclusion criteria. The Silk device was implanted in 16 patients (47%, single device in 15), the Pipeline device in 18 (53%, single device in 16). On first follow-up angiography, in-stent stenosis was observed in 38% of Silk devices and 39% of Pipeline devices. In-stent stenosis was asymptomatic in 12 of 13 patients. One woman presented with transient ischemic attacks and required stent angioplasty due to end tapering and mild, diffuse in-stent stenosis. Configuration and location changes, including stent creeping and end tapering were seen in 2/16 patients (13%) with Silk devices, and 0/18 patients with Pipeline devices. We describe stent creeping and end tapering as unusual findings with the potential for delayed clinical complications. In-stent stenosis, with a unique behavior, is a frequent angiographic finding observed after flow-diverter stent implant. The stenosis is usually asymptomatic; however, close clinical and angiographic monitoring is mandatory for individualized management.

  2. Successful treatment of a giant pediatric fusiform basilar trunk aneurysm with surpass flow diverter.

    PubMed

    Kan, Peter; Mokin, Maxim; Puri, Ajit S; Wakhloo, Ajay K

    2016-06-01

    Fusiform aneurysms present a unique challenge to traditional microsurgical and endovascular treatment because of the lack of a discernible neck and the involvement of parent vessel. Flow diversion has increasingly become the treatment of choice for fusiform aneurysms in the anterior circulation, but its results in the posterior circulation are variable. We report successful treatment of a giant fusiform upper basilar trunk aneurysm with the Surpass flow diverter in an adolescent, and discuss the potential advantages of this emerging technology in the treatment of fusiform posterior circulation aneurysms.

  3. Successful treatment of a giant pediatric fusiform basilar trunk aneurysm with surpass flow diverter.

    PubMed

    Kan, Peter; Mokin, Maxim; Puri, Ajit S; Wakhloo, Ajay K

    2015-06-03

    Fusiform aneurysms present a unique challenge to traditional microsurgical and endovascular treatment because of the lack of a discernible neck and the involvement of parent vessel. Flow diversion has increasingly become the treatment of choice for fusiform aneurysms in the anterior circulation, but its results in the posterior circulation are variable. We report successful treatment of a giant fusiform upper basilar trunk aneurysm with the Surpass flow diverter in an adolescent, and discuss the potential advantages of this emerging technology in the treatment of fusiform posterior circulation aneurysms.

  4. Abruptly autofocusing terahertz waves with meta-hologram.

    PubMed

    He, Jingwen; Wang, Sen; Xie, Zhenwei; Ye, Jiasheng; Wang, Xinke; Kan, Qiang; Zhang, Yan

    2016-06-15

    An abruptly autofocusing ring-Airy beam is demonstrated in the terahertz (THz) waveband with a meta-hologram. The designed meta-hologram is composed of gold C-shaped slot antennas, which can realize both phase and amplitude modulation of the incident THz wave. A THz holographic imaging system is utilized to measure the generated ring-Airy beam; an abrupt focus following a parabolic trajectory is subsequently observed. THz ring-Airy beams with different parameters are also generated and investigated. This method can be expanded to other wavebands, such as the visible band, for which the meta-hologram can replace traditional computer-generated holography to avoid undesirable multiple diffraction orders.

  5. Abruptly autofocusing terahertz waves with meta-hologram.

    PubMed

    He, Jingwen; Wang, Sen; Xie, Zhenwei; Ye, Jiasheng; Wang, Xinke; Kan, Qiang; Zhang, Yan

    2016-06-15

    An abruptly autofocusing ring-Airy beam is demonstrated in the terahertz (THz) waveband with a meta-hologram. The designed meta-hologram is composed of gold C-shaped slot antennas, which can realize both phase and amplitude modulation of the incident THz wave. A THz holographic imaging system is utilized to measure the generated ring-Airy beam; an abrupt focus following a parabolic trajectory is subsequently observed. THz ring-Airy beams with different parameters are also generated and investigated. This method can be expanded to other wavebands, such as the visible band, for which the meta-hologram can replace traditional computer-generated holography to avoid undesirable multiple diffraction orders. PMID:27304289

  6. The role of the thermohaline circulation in abrupt climate change.

    PubMed

    Clark, Peter U; Pisias, Nicklas G; Stocker, Thomas F; Weaver, Andrew J

    2002-02-21

    The possibility of a reduced Atlantic thermohaline circulation in response to increases in greenhouse-gas concentrations has been demonstrated in a number of simulations with general circulation models of the coupled ocean-atmosphere system. But it remains difficult to assess the likelihood of future changes in the thermohaline circulation, mainly owing to poorly constrained model parameterizations and uncertainties in the response of the climate system to greenhouse warming. Analyses of past abrupt climate changes help to solve these problems. Data and models both suggest that abrupt climate change during the last glaciation originated through changes in the Atlantic thermohaline circulation in response to small changes in the hydrological cycle. Atmospheric and oceanic responses to these changes were then transmitted globally through a number of feedbacks. The palaeoclimate data and the model results also indicate that the stability of the thermohaline circulation depends on the mean climate state.

  7. Recommended Experimental Procedures for Evaluation of Abrupt Wing Stall Characteristics

    NASA Technical Reports Server (NTRS)

    Capone, F. J.; Hall, R. M.; Owens, D. B.; Lamar, J. E.; McMillin, S. N.

    2003-01-01

    This paper presents a review of the experimental program under the Abrupt Wing Stall (AWS) Program. Candidate figures of merit from conventional static tunnel tests are summarized and correlated with data obtained in unique free-to-roll tests. Where possible, free-to-roll results are also correlated with flight data. Based on extensive studies of static experimental figures of merit in the Abrupt Wing Stall Program for four different aircraft configurations, no one specific figure of merit consistently flagged a warning of potential lateral activity when actual activity was seen to occur in the free-to-roll experiments. However, these studies pointed out the importance of measuring and recording the root mean square signals of the force balance.

  8. [Traumatic abruption of the placenta with disseminated intravascular coagulation].

    PubMed

    Benz, R; Malär, A-U; Benz-Wörner, J; Scherer, M; Hodel, M; Gähler, A; Haberthür, C; Konrad, C

    2012-10-01

    Trauma in pregnancy is infrequent and a systematic primary strategy constitutes a real challenge for the interdisciplinary team. With a high fetal mortality rate and a substantial maternal mortality rate traumatic placental abruption is a severe emergency which every anesthetist should be aware of. After hemodynamic stabilization of the mother and control of the viability of the fetus the therapy of traumatic placental abruption consists mostly of an immediate caesarean section. Coagulopathy by depletion of coagulation factors as well as disseminated intravascular coagulation (DIC) have to be expected and consequently a massive blood loss must be anticipated. Thrombelastography provides assistance for fast differential diagnosis and goal-directed treatment of the disturbed sections of the coagulation cascade.

  9. The role of the thermohaline circulation in abrupt climate change.

    PubMed

    Clark, Peter U; Pisias, Nicklas G; Stocker, Thomas F; Weaver, Andrew J

    2002-02-21

    The possibility of a reduced Atlantic thermohaline circulation in response to increases in greenhouse-gas concentrations has been demonstrated in a number of simulations with general circulation models of the coupled ocean-atmosphere system. But it remains difficult to assess the likelihood of future changes in the thermohaline circulation, mainly owing to poorly constrained model parameterizations and uncertainties in the response of the climate system to greenhouse warming. Analyses of past abrupt climate changes help to solve these problems. Data and models both suggest that abrupt climate change during the last glaciation originated through changes in the Atlantic thermohaline circulation in response to small changes in the hydrological cycle. Atmospheric and oceanic responses to these changes were then transmitted globally through a number of feedbacks. The palaeoclimate data and the model results also indicate that the stability of the thermohaline circulation depends on the mean climate state. PMID:11859359

  10. Ultra-wideband horn antenna with abrupt radiator

    DOEpatents

    McEwan, Thomas E.

    1998-01-01

    An ultra-wideband horn antenna transmits and receives impulse waveforms for short-range radars and impulse time-of flight systems. The antenna reduces or eliminates various sources of close-in radar clutter, including pulse dispersion and ringing, sidelobe clutter, and feedline coupling into the antenna. Dispersion is minimized with an abrupt launch point radiator element; sidelobe and feedline coupling are minimized by recessing the radiator into a metallic horn. Low frequency cut-off associated with a horn is extended by configuring the radiator drive impedance to approach a short circuit at low frequencies. A tapered feed plate connects at one end to a feedline, and at the other end to a launcher plate which is mounted to an inside wall of the horn. The launcher plate and feed plate join at an abrupt edge which forms the single launch point of the antenna.

  11. Ultra-wideband horn antenna with abrupt radiator

    DOEpatents

    McEwan, T.E.

    1998-05-19

    An ultra-wideband horn antenna transmits and receives impulse waveforms for short-range radars and impulse time-of flight systems. The antenna reduces or eliminates various sources of close-in radar clutter, including pulse dispersion and ringing, sidelobe clutter, and feedline coupling into the antenna. Dispersion is minimized with an abrupt launch point radiator element; sidelobe and feedline coupling are minimized by recessing the radiator into a metallic horn. Low frequency cut-off associated with a horn is extended by configuring the radiator drive impedance to approach a short circuit at low frequencies. A tapered feed plate connects at one end to a feedline, and at the other end to a launcher plate which is mounted to an inside wall of the horn. The launcher plate and feed plate join at an abrupt edge which forms the single launch point of the antenna. 8 figs.

  12. The Silk flow-diverter stent for endovascular treatment of intracranial aneurysms.

    PubMed

    Alghamdi, Faisal; Morais, Ricardo; Scillia, Pietro; Lubicz, Boris

    2015-01-01

    Flow diverter (FD) stents represent a new endovascular technique developed for the treatment of complex intracranial aneurysms (wide neck, fusiform, large, and giant aneurysms) that are challenging for classic endovascular techniques such as coiling, balloon-assisted coiling and stent-assisted coiling. Low porosity, high metal coverage, and high pore density are the main properties of FD stents. These properties induce hemodynamic changes redirecting the blood flow away from the aneurysm and into the parent artery leading to gradual thrombosis of the aneurysm. FD stents also provide scaffolding for subsequent neoendothelial proliferation, and vessel wall remodeling. This is considered as a paradigm shift compared to prior endovascular methods, which predominantly aimed at providing treatment inside the aneurysmal sac. This paper describes in detail the first released FD stent, the Silk flow-diverter stent (Balt Extrusion, Montmorency, France), its mechanism of action and deployment technique. It reviews the pertinent literature regarding safety, efficacy and potential risks and complications associated with the use of this stent.

  13. Role of water-soluble enema before takedown of diverting ileostomy for low pelvic anastomosis.

    PubMed

    Karsten, Benjamin J; King, Justin B; Kumar, Ravin R

    2009-10-01

    The integrity of a low pelvic anastomosis is often studied radiographically before takedown of a diverting ileostomy. The aim of this study is to determine the impact of routine water-soluble enema studies (WSE) in our patient population with low pelvic anastomosis. We retrospectively reviewed the operative database for a county teaching hospital from 1998 to 2008. All patients with low pelvic anastomosis (ultralow colorectal, coloanal, and ileoanal pouch anastomosis) with diverting ileostomy who underwent subsequent takedown were identified. Fifty patients met inclusion criteria. Thirty-eight patients were evaluated by WSE and 12 were not. Twenty-five patients (66%) were noted to have normal WSE studies before ostomy takedown. Thirteen patients (26%) were noted to have abnormalities on WSE. Two stenoses were clinically significant. Water-soluble enema study was 100 per cent sensitive and 69 per cent specific for detecting significant pathology. Digital rectal examination (DRE), colonoscopy, and flexible sigmoidoscopy were also 100 per cent sensitive in detecting substantial pathology. Routine use of WSE failed to demonstrate a significant impact on patients with low pelvic anastomosis undergoing ileostomy takedown. Routine DRE and rigid proctoscopy can be used to evaluate low pelvic anastomosis. WSE can be used selectively on patients with abnormal findings. PMID:19886140

  14. A Rare Cause of Placental Abruption: Uterine Torsion.

    PubMed

    Ulu, Ipek; Güneş, Muhammed Siraç; Kiran, Gürkan; Gülşen, Mehmet Serdar

    2016-01-01

    Uterine torsion is defined as a rotation on its long axis and it is a dangerous, unexpected obstetric emergency. We report a case of uterine torsion at 32 weeks of gestation in a singleton pregnancy. A 37-year-old woman with multiple prior cesarean deliveries referred to emergency unit of our hospital at 32 weeks of gestation with severe abdominal pain and mild vaginal bleeding. Ultrasonography showed a single fetus in vertex position, with a normal amniotic fluid. Fetal biometer was appropriate for 32 weeks of gestation. Placental location was anterior with a subchorionic hypoechogenic small area which was suspected to be a sign of placental abruption. An emergency cesarean section was performed under general anesthesia. The 180° uterine torsion was diagnosed and it was not possible to perform detorsion of the gravid uterus by exteriorization by pfannenstiel incision. Posterior hysterotomy was performed and a male baby of 1830 grams weight was delivered. The newborn was transported to Neonatal Intensive Care Unit (NICU) of another hospital and discharged within two weeks. Patient recovered well and was discharged on second postoperation day. Uterine torsion is a very rare and life threatening situation. In unexpected cases posterior low transuerse hysterotomy is generally performed and it is suggested as a safe choice when detorsion was not accomplished. It is not easy to keep in mind the possibility of uterine torsion in cases of abdominal pain during pregnancy. Because it generally causes abruption, management of abruption is vitally important to prevent fetal mortality. PMID:26894131

  15. Continuous methane record of abrupt climate change 10-68 ka: sighting Heinrich events in the ice core record

    NASA Astrophysics Data System (ADS)

    Rhodes, Rachael; Brook, Edward; Chiang, John; Blunier, Thomas; Cheng, Hai; Edwards, R. Lawrence; Maselli, Olivia; McConnell, Joseph; Romanini, Daniele; Severinghaus, Jeffrey; Sowers, Todd; Stowasser, Christopher

    2014-05-01

    The Last Glacial period was punctuated by millennial scale abrupt climate changes - Dansgaard-Oeschger (D-O) cycles and Heinrich events. Controls on the magnitude and frequency of these climate perturbations, and how they may be inter-related, remain unclear. Specific problems include the difficulty of dating Heinrich sediment layers and local bias of key paleoclimate archives. We present a highly detailed and precise record of ice core methane (CH4), a globally integrated signal, which resolves climatic features in unprecedented resolution. Abrupt CH4 increases are resolved in Heinrich Stadials (HS) 1, 2, 4 and 5 where, in contrast to all D-O cycles, there are no concurrent abrupt changes in Greenland temperature. Using modern-day tropical rainfall variability as an analog, we propose that strong cooling in the North Atlantic severely restricted the northerly range of the Intertropical Convergence Zone (ITCZ), leading to an enhanced wet season over Southern Hemisphere tropical land areas, and consequently driving production of excess CH4 in tropical wetlands. Our findings place four Heinrich events firmly within ice core chronologies and suggest maximum durations of 778 to 1606 yr. CH4 anomalies are only associated with Heinrich events of Hudson Strait provenance, indicating that the tropical impacts of Heinrich events were not uniform.

  16. Rotary seal with enhanced lubrication and contaminant flushing

    DOEpatents

    Dietle, Lannie L.

    2000-01-01

    A resilient, ring shaped interference-type hydrodynamic rotary seal having waves on the lubricant side which provide increased film thickness and flushing action by creating contact pressure induced angulated restrictions formed by abrupt restrictive diverters. The angulated restrictions are defined by projecting ridges, corners at the trailing edge of the waves, or simply by use of a converging shape at the trailing edge of the waves which is more abrupt than the gently converging hydrodynamic inlet shape at the leading edge of the waves. The abrupt restrictive diverter performs two functions; a restricting function and a diverting function. The angulated restrictions cause a local film thickness restriction which produces a damming effect preventing a portion of the lubricant from leaking out of the dynamic sealing interface at the trailing edge of the wave, and results in a much thicker lubricant film thickness under the waves. This contributes to more film thickness in the remainder of the dynamic sealing interface toward the environment because film thickness tends to decay gradually rather than abruptly due to the relative stiffness of the seal material. Because of the angle of the abrupt restrictive diverter relative to the relative rotation direction, in conjunction with the restriction or damming effect, a strong diverting action is produced which pumps lubricant across the dynamic sealing interface toward the environment. The lubricant diversion is caused by the component of the rotational velocity tangent to the abrupt restrictive diverter. The component of rotational velocity normal to the abrupt restrictive diverter causes a portion of the lubricant film to be pumped past the abrupt restrictive diverter, thereby assuring adequate lubrication thereof.

  17. The first North American use of the Pipeline Flex flow diverter.

    PubMed

    Duckworth, Edward A M; Nickele, Christopher; Hoit, Daniel; Belayev, Andrey; Moran, Christopher J; Arthur, Adam S

    2016-02-01

    Flow diversion for the management of intracranial aneurysms represents a paradigm shift in how aneurysms are managed. The Pipeline embolization device (PED) is, to date, the only flow diverter approved for use in the USA by the Food and Drug Administration. Limitations and complications with new treatment strategies are inevitable, and with the PED there have been reports of complications, most commonly with challenging deployments. Once deployment has been initiated, the device is 'one-way'; it can only be deployed further or removed. Yet, situations arise in which the ability to recapture or reposition the device would be advantageous. A second-generation Pipeline has been developed that addresses these concerns. We report the first use in North America of this second-generation Pipeline device: the Pipeline Flex. We discuss our rationale for using the device, our impressions of its operation, and the relevant literature concerning the current state of flow diversion.

  18. Oncogenic Ras diverts a host TNF tumor suppressor activity into tumor promoter.

    PubMed

    Cordero, Julia B; Macagno, Juan P; Stefanatos, Rhoda K; Strathdee, Karen E; Cagan, Ross L; Vidal, Marcos

    2010-06-15

    The roles of inflammatory cytokines and the immune response in cancer remain paradoxical. In the case of tumor necrosis factor (TNF), there is undisputed evidence indicating both protumor and antitumor activities. Recent work in Drosophila indicated that a TNF-dependent mechanism eliminates cells deficient for the polarity tumor suppressors dlg or scrib. In this study, however, we show that in tumors deficient for scrib that also expressed the Ras oncoprotein, the TNF signal was diverted into a protumor signal that enhanced tumor growth through larval arrest and stimulated invasive migration. In this case, TNF promoted malignancy and was detrimental to host survival. TNF was expressed at high levels by tumor-associated hemocytes recruited from the circulation. The expression of TNF by hemocytes was both necessary and sufficient to trigger TNF signaling in tumor cells. Our evidence suggests that tumors can evolve into malignancy through oncogenic Ras activation and the hijacking of TNF signaling.

  19. A 12-month prospective comparison of court-diverted with self-referred heroin users.

    PubMed

    Desland, M L; Batey, R G

    1992-01-01

    Forty-seven heroin users referred by the Drug and Alcohol Court Assessment Programme (DACAP) were compared with 45 self-referred heroin users at 12 months post-presentation. Data at presentation indicated distinct subpopulations were generated by each referral source. Differences were recorded in age, heroin use, marital status, educational level, employment history and age of onset of anti-social behaviour. The DACAP scheme exerted an earlier health intervention effect in a sample experiencing dysfunction in other areas, principally legally and socially. Prospective data demonstrated that both samples reported significant reductions in the proportion using heroin. Differences between samples evident at presentation were expressed prospectively, in rates of employment, incarceration and involvement in methadone maintenance programmes. The limitations of diverting clientele from the legal system to the treatment system is discussed in light of these results.

  20. Hemodynamic impact of cerebral aneurysm endovascular treatment devices: coils and flow diverters.

    PubMed

    Goubergrits, Leonid; Schaller, Jens; Kertzscher, Ulrich; Woelken, Thies; Ringelstein, Moritz; Spuler, Andreas

    2014-07-01

    Coils and flow diverters or stents are devices successfully used to treat cerebral aneurysms. Treatment aims to reduce intra-aneurysmal flow, thereby separating the aneurysmal sac from the blood circulation. The focus and this manuscript combining literature review and our original research is an analysis of changes in aneurysmal hemodynamics caused by endovascular treatment devices. Knowledge of post-treatment hemodynamics is a path to successful long-term treatment. Summarizing findings on hemodynamic impact of treatment devices, we conclude: coiling and stenting do not affect post-treatment intra-aneurysmal pressure, but significantly alter aneurysmal hemodynamics through flow reduction and a change in flow structure. The impact of treatment devices on aneurysmal flow depends, however, on a set of parameters including device geometry, course of placement, parent vessel and aneurysm geometry.

  1. Microscopic Motion of Liquid Metal Plasma Facing Components In A Diverted Plasma

    SciTech Connect

    Jaworski, M A; Morley, N B; Abrams, T; Kaita, R; Kallman, J; Kugel, H; Majeski, R

    2010-09-22

    Liquid metal plasma facing components (PFCs) have been identified as an alternative material for fusion plasma experiments. The use of a liquid conductor where significant magnetic fields are present is considered risky, with the possibility of macroscopic fluid motion and possible ejection into the plasma core. Analysis is carried out on thermoelectric magnetohydrodynamic (TEMHD) forces caused by temperature gradients in the liquid-container system itself in addition to scrape-off-layer currents interacting with the PFC from a diverted plasma. Capillary effects at the liquid-container interface will be examined which govern droplet ejection criteria. Stability of the interface is determined using linear stability methods. In addition to application to liquidmetal PFCs, thin film liquidmetal effects have application to current and future devices where off-normal events may liquefy portions of the first wall and other plasma facing components.

  2. A new flow diverter stent for direct treatment of intracranial aneurysm.

    PubMed

    Ma, Jiayao; You, Zhong; Peach, Thomas; Byrne, James; Rizkallah, Rafik R

    2015-12-16

    The use of a stand-alone flow diverter (FD) stent has demonstrated itself as an efficacious endovascular approach to intracranial aneurysm treatment. FD stents that are currently available adopt an interwoven braided design. The relatively low radial stiffness intrinsic to this design could cause difficulty in deployment and poor stent-wall apposition, leading to high complication rates. A new FD stent is proposed to overcome the problems of the interwoven FD stents. The new device is manufactured from a Nitinol tube through a laser-cutting technique, and its unique structure allows for both low porosity and high packaging efficiency. Computational simulation using Abaqus has been conducted to investigate the radial stiffness and longitudinal flexibility of the new device. The new device exhibits high radial stiffness when compared to interwoven FD stents and superior longitudinal flexibility. Results from on-going in-vivo experiments and CFD simulations have also demonstrated the efficacy of the new device as a FD stent.

  3. Numerical Studies of an Array of Fluidic Diverter Actuators for Flow Control

    NASA Technical Reports Server (NTRS)

    Gokoglu, Suleyman A.; Kuczmarski, Maria A.; Culley, Dennis E.; Raghu, Surya

    2011-01-01

    In this paper, we study the effect of boundary conditions on the behavior of an array of uniformly-spaced fluidic diverters with an ultimate goal to passively control their output phase. This understanding will aid in the development of advanced designs of actuators for flow control applications in turbomachinery. Computations show that a potential design is capable of generating synchronous outputs for various inlet boundary conditions if the flow inside the array is initiated from quiescence. However, when the array operation is originally asynchronous, several approaches investigated numerically demonstrate that re-synchronization of the actuators in the array is not practical since it is very sensitive to asymmetric perturbations and imperfections. Experimental verification of the insights obtained from the present study is currently being pursued.

  4. Given Resource Constraints, It Would Be Unethical To Divert Antiretroviral Drugs From Treatment To Prevention

    PubMed Central

    Macklin, Ruth; Cowan, Ethan

    2013-01-01

    Striking advances in HIV prevention have set the stage for renewed debate on setting priorities in the fight against HIV/AIDS. Two new prevention strategies preexposure prophylaxis and treatment as prevention—use antiretroviral drugs for prevention of HIV/AIDS in addition to treating patients. The potential for success of these new prevention strategies sets up an ethical dilemma: where resources are limited and supplies of lifesaving antiretroviral medications are insufficient to treat those currently living with HIV, how should these resources be divided between treatment and prevention? This article explores several ethical principles used in formulating public health policy. Assuming that limited resources are available for spending on drugs, we conclude that it would be unethical to watch patients with treatable AIDS worsen and die, even with supportive care, so that medications for treatment can be diverted for prevention. PMID:22778343

  5. The first North American use of the Pipeline Flex flow diverter.

    PubMed

    Duckworth, Edward A M; Nickele, Christopher; Hoit, Daniel; Belayev, Andrey; Moran, Christopher J; Arthur, Adam S

    2015-01-30

    Flow diversion for the management of intracranial aneurysms represents a paradigm shift in how aneurysms are managed. The Pipeline embolization device (PED) is, to date, the only flow diverter approved for use in the USA by the Food and Drug Administration. Limitations and complications with new treatment strategies are inevitable, and with the PED there have been reports of complications, most commonly with challenging deployments. Once deployment has been initiated, the device is 'one-way'; it can only be deployed further or removed. Yet, situations arise in which the ability to recapture or reposition the device would be advantageous. A second-generation Pipeline has been developed that addresses these concerns. We report the first use in North America of this second-generation Pipeline device: the Pipeline Flex. We discuss our rationale for using the device, our impressions of its operation, and the relevant literature concerning the current state of flow diversion.

  6. Treatment of Intracranial Aneurysms Using Flow-Diverting Silk Stents (BALT): a Single Centre Experience

    PubMed Central

    Leonardi, M.; Cirillo, L.; Toni, F.; Dall’Olio, M.; Princiotta, C.; Stafa, A.; Simonetti, L.; Agati, R.

    2011-01-01

    Summary The Silk stent (Balt, Montmorency, France) is a retractable device designed to achieve curative reconstruction of the parent artery associated with an intracranial aneurysm. We present our initial experience with the Silk flow-diverting stent in the management and follow-up of 25 patients presenting with intracranial aneurysms. Twenty-five patients (age range, 34-81 years; 24 female) were treated with the Silk flow-diverting device. Aneurysms ranged in size from small (5), large (10) and giant (10) and included wide-necked aneurysms, multiple, nonsaccular, and recurrent intracranial aneurysms. Nine aneurysms were treated for headache, 14 for mass effect. None presented with haemorrhage. All patients were pretreated with dual antiplatelet medications for at least 72 hours before surgery and continued taking both agents for at least three months after treatment. A total of 25 Silk stents were used. Control MR angiography and/or CT angiography was typically performed prior to discharge and at one, three, six and 12 months post treatment. A follow-up digital subtraction angiogram was performed between six and 19 months post treatment. Complete angiographic occlusion or subtotal occlusion was achieved in 15 patients in a time frame from three days to 12 months. Three deaths and one major complication were encountered during the study period. Two patients, all with cavernous giant aneurysms, experienced transient exacerbations of preexisting cranial neuropathies and headache after the Silk treatment. Both were treated with corticosteroids, and symptoms resolved completely within a month. In our experience the Silk stent has proven to be a valuable tool in the endovascular treatment of intracranial giant partially thrombosed aneurysms and aneurysms of the internal carotid artery cavernous segment presenting with mass effect. The time of complete occlusion of the aneurysms and the risk of the bleeding is currently not predictable. PMID:22005692

  7. Fluidic low-frequency oscillator consisting of load-switched diverter and a pair of vortex chambers

    NASA Astrophysics Data System (ADS)

    Tesař, Václav; Peszynski, Kazimierz; Smyk, Emil

    2016-03-01

    Paper discusses a new configuration of fluidic oscillators, a subject of recent Patent application. There is some similarity with the standard Warren oscillator with its bistable jet-deflection diverter and two feedbacks - which is not suitable for situations demanding very low oscillation frequency. For these conditions the new design replaces jet-deflection switching in the diverter by load-switching effects, with the gradually increased loading by spin-up of fluid in the vortex chambers. The spin-up time also provides the needed time delays. Behaviour is characterised by the oscillation frequency increasing with increasing fluid flow rate - for which was derived a surprisingly simple theoretical solution.

  8. Superior mesenteric artery thrombosis after abrupt discontinuation of rivaroxaban.

    PubMed

    Adams, Christopher B; Acquisto, Nicole M; Rotoli, Jason M; LoStracco, Thomas; Shamaskin, Ann R; Pasternack, Joel S

    2016-04-01

    We report a case of superior mesenteric artery thrombosis after the abrupt discontinuation of rivaroxaban in a 59-year-old male patient. The initial presentation was of sudden onset abdominal pain, nausea, vomiting, diarrhea, and hematochezia in the setting of recently holding rivaroxaban anticoagulation for an atrial flutter ablative procedure. Imaging revealed thrombosis of the superior mesenteric artery and acute mesenteric ischemia requiring emergent surgical intervention for embolectomy. Upon exploratory laparotomy, the bowel was found to be viable, and an embolectomy with patch angioplasty was successful without complication. This case illustrates the need for emergency medicine clinician familiarity with this possible medication adverse event with rivaroxaban.

  9. Shock wave interaction with an abrupt area change

    NASA Technical Reports Server (NTRS)

    Salas, Manuel D.

    1991-01-01

    The wave patterns that occur when a shock wave interacts with an abrupt area changed are analyzed in terms of the incident shock wave Mach number and area-jump ratio. The solutions predicted by a semi-similar models are in good agreement with those obtained numerically from the quasi-one-dimensional time-dependent Euler equations. The entropy production for the wave system is defined and the principle of minimum entropy production is used to resolve a nonuniqueness problem of the self-similar model.

  10. Investigations of Abrupt Movements of Optically Trapped Water Droplets

    NASA Astrophysics Data System (ADS)

    Murphy, Shawntel; McCann, Lowell I.

    2007-03-01

    We have used a single beam optical trap (optical tweezers) to capture individual water droplets in air. A 3-dimensional viewing system consisting of a two axis microscope allows the trapped droplet to be viewed from the top and the side simultaneously. The position of the droplet is determined with a digital camera at a rate up to 700Hz. We have observed abrupt movements along the beam in two situations: As a pure water droplet evaporates, the movements occur at specific size intervals as the diameter decreases. For non-evaporating saltwater droplets the movements rapidly occur for certain ranges of beam power, and not at all for other ranges of power.

  11. Standby energy conservation plan no. 2: Building temperature restrictions plan

    NASA Astrophysics Data System (ADS)

    1980-02-01

    The environmental impacts of the proposed building temperature restrictions plan are analyzed. The plan would result in fuel and energy savings which could be diverted to other areas. Environmental impacts, with emphasis on air quality, were analyzed and found to result in a very minor improvement in air quality. Public health impacts are also minimal, and although some individuals may experience discomfort, it can be minimized by adjustments in clothing. The change in temperature is insufficient to have any significant impact on persons suffering from most diseases.

  12. Abrupt climate change and collapse of deep-sea ecosystems

    USGS Publications Warehouse

    Yasuhara, Moriaki; Cronin, T. M.; Demenocal, P.B.; Okahashi, H.; Linsley, B.K.

    2008-01-01

    We investigated the deep-sea fossil record of benthic ostracodes during periods of rapid climate and oceanographic change over the past 20,000 years in a core from intermediate depth in the northwestern Atlantic. Results show that deep-sea benthic community "collapses" occur with faunal turnover of up to 50% during major climatically driven oceanographic changes. Species diversity as measured by the Shannon-Wiener index falls from 3 to as low as 1.6 during these events. Major disruptions in the benthic communities commenced with Heinrich Event 1, the Inter-Aller??d Cold Period (IACP: 13.1 ka), the Younger Dryas (YD: 12.9-11.5 ka), and several Holocene Bond events when changes in deep-water circulation occurred. The largest collapse is associated with the YD/IACP and is characterized by an abrupt two-step decrease in both the upper North Atlantic Deep Water assemblage and species diversity at 13.1 ka and at 12.2 ka. The ostracode fauna at this site did not fully recover until ???8 ka, with the establishment of Labrador Sea Water ventilation. Ecologically opportunistic slope species prospered during this community collapse. Other abrupt community collapses during the past 20 ka generally correspond to millennial climate events. These results indicate that deep-sea ecosystems are not immune to the effects of rapid climate changes occurring over centuries or less. ?? 2008 by The National Academy of Sciences of the USA.

  13. North Pacific deglacial hypoxic events linked to abrupt ocean warming.

    PubMed

    Praetorius, S K; Mix, A C; Walczak, M H; Wolhowe, M D; Addison, J A; Prahl, F G

    2015-11-19

    Marine sediments from the North Pacific document two episodes of expansion and strengthening of the subsurface oxygen minimum zone (OMZ) accompanied by seafloor hypoxia during the last deglacial transition. The mechanisms driving this hypoxia remain under debate. We present a new high-resolution alkenone palaeotemperature reconstruction from the Gulf of Alaska that reveals two abrupt warming events of 4-5 degrees Celsius at the onset of the Bølling and Holocene intervals that coincide with sudden shifts to hypoxia at intermediate depths. The presence of diatomaceous laminations and hypoxia-tolerant benthic foraminiferal species, peaks in redox-sensitive trace metals, and enhanced (15)N/(14)N ratio of organic matter, collectively suggest association with high export production. A decrease in (18)O/(16)O values of benthic foraminifera accompanying the most severe deoxygenation event indicates subsurface warming of up to about 2 degrees Celsius. We infer that abrupt warming triggered expansion of the North Pacific OMZ through reduced oxygen solubility and increased marine productivity via physiological effects; following initiation of hypoxia, remobilization of iron from hypoxic sediments could have provided a positive feedback on ocean deoxygenation through increased nutrient utilization and carbon export. Such a biogeochemical amplification process implies high sensitivity of OMZ expansion to warming.

  14. The abrupt onset of the modern South Asian Monsoon winds.

    PubMed

    Betzler, Christian; Eberli, Gregor P; Kroon, Dick; Wright, James D; Swart, Peter K; Nath, Bejugam Nagender; Alvarez-Zarikian, Carlos A; Alonso-García, Montserrat; Bialik, Or M; Blättler, Clara L; Guo, Junhua Adam; Haffen, Sébastien; Horozal, Senay; Inoue, Mayuri; Jovane, Luigi; Lanci, Luca; Laya, Juan Carlos; Mee, Anna Ling Hui; Lüdmann, Thomas; Nakakuni, Masatoshi; Niino, Kaoru; Petruny, Loren M; Pratiwi, Santi D; Reijmer, John J G; Reolid, Jesús; Slagle, Angela L; Sloss, Craig R; Su, Xiang; Yao, Zhengquan; Young, Jeremy R

    2016-07-20

    The South Asian Monson (SAM) is one of the most intense climatic elements yet its initiation and variations are not well established. Dating the deposits of SAM wind-driven currents in IODP cores from the Maldives yields an age of 12. 9 Ma indicating an abrupt SAM onset, over a short period of 300 kyrs. This coincided with the Indian Ocean Oxygen Minimum Zone expansion as revealed by geochemical tracers and the onset of upwelling reflected by the sediment's content of particulate organic matter. A weaker 'proto-monsoon' existed between 12.9 and 25 Ma, as mirrored by the sedimentary signature of dust influx. Abrupt SAM initiation favors a strong influence of climate in addition to the tectonic control, and we propose that the post Miocene Climate Optimum cooling, together with increased continentalization and establishment of the bipolar ocean circulation, i.e. the beginning of the modern world, shifted the monsoon over a threshold towards the modern system.

  15. The abrupt onset of the modern South Asian Monsoon winds

    NASA Astrophysics Data System (ADS)

    Betzler, Christian; Eberli, Gregor P.; Kroon, Dick; Wright, James D.; Swart, Peter K.; Nath, Bejugam Nagender; Alvarez-Zarikian, Carlos A.; Alonso-García, Montserrat; Bialik, Or M.; Blättler, Clara L.; Guo, Junhua Adam; Haffen, Sébastien; Horozal, Senay; Inoue, Mayuri; Jovane, Luigi; Lanci, Luca; Laya, Juan Carlos; Mee, Anna Ling Hui; Lüdmann, Thomas; Nakakuni, Masatoshi; Niino, Kaoru; Petruny, Loren M.; Pratiwi, Santi D.; Reijmer, John J. G.; Reolid, Jesús; Slagle, Angela L.; Sloss, Craig R.; Su, Xiang; Yao, Zhengquan; Young, Jeremy R.

    2016-07-01

    The South Asian Monson (SAM) is one of the most intense climatic elements yet its initiation and variations are not well established. Dating the deposits of SAM wind-driven currents in IODP cores from the Maldives yields an age of 12. 9 Ma indicating an abrupt SAM onset, over a short period of 300 kyrs. This coincided with the Indian Ocean Oxygen Minimum Zone expansion as revealed by geochemical tracers and the onset of upwelling reflected by the sediment’s content of particulate organic matter. A weaker ‘proto-monsoon’ existed between 12.9 and 25 Ma, as mirrored by the sedimentary signature of dust influx. Abrupt SAM initiation favors a strong influence of climate in addition to the tectonic control, and we propose that the post Miocene Climate Optimum cooling, together with increased continentalization and establishment of the bipolar ocean circulation, i.e. the beginning of the modern world, shifted the monsoon over a threshold towards the modern system.

  16. The abrupt onset of the modern South Asian Monsoon winds

    PubMed Central

    Betzler, Christian; Eberli, Gregor P.; Kroon, Dick; Wright, James D.; Swart, Peter K.; Nath, Bejugam Nagender; Alvarez-Zarikian, Carlos A.; Alonso-García, Montserrat; Bialik, Or M.; Blättler, Clara L.; Guo, Junhua Adam; Haffen, Sébastien; Horozal, Senay; Inoue, Mayuri; Jovane, Luigi; Lanci, Luca; Laya, Juan Carlos; Mee, Anna Ling Hui; Lüdmann, Thomas; Nakakuni, Masatoshi; Niino, Kaoru; Petruny, Loren M.; Pratiwi, Santi D.; Reijmer, John J. G.; Reolid, Jesús; Slagle, Angela L.; Sloss, Craig R.; Su, Xiang; Yao, Zhengquan; Young, Jeremy R.

    2016-01-01

    The South Asian Monson (SAM) is one of the most intense climatic elements yet its initiation and variations are not well established. Dating the deposits of SAM wind-driven currents in IODP cores from the Maldives yields an age of 12. 9 Ma indicating an abrupt SAM onset, over a short period of 300 kyrs. This coincided with the Indian Ocean Oxygen Minimum Zone expansion as revealed by geochemical tracers and the onset of upwelling reflected by the sediment’s content of particulate organic matter. A weaker ‘proto-monsoon’ existed between 12.9 and 25 Ma, as mirrored by the sedimentary signature of dust influx. Abrupt SAM initiation favors a strong influence of climate in addition to the tectonic control, and we propose that the post Miocene Climate Optimum cooling, together with increased continentalization and establishment of the bipolar ocean circulation, i.e. the beginning of the modern world, shifted the monsoon over a threshold towards the modern system. PMID:27436574

  17. The abrupt onset of the modern South Asian Monsoon winds.

    PubMed

    Betzler, Christian; Eberli, Gregor P; Kroon, Dick; Wright, James D; Swart, Peter K; Nath, Bejugam Nagender; Alvarez-Zarikian, Carlos A; Alonso-García, Montserrat; Bialik, Or M; Blättler, Clara L; Guo, Junhua Adam; Haffen, Sébastien; Horozal, Senay; Inoue, Mayuri; Jovane, Luigi; Lanci, Luca; Laya, Juan Carlos; Mee, Anna Ling Hui; Lüdmann, Thomas; Nakakuni, Masatoshi; Niino, Kaoru; Petruny, Loren M; Pratiwi, Santi D; Reijmer, John J G; Reolid, Jesús; Slagle, Angela L; Sloss, Craig R; Su, Xiang; Yao, Zhengquan; Young, Jeremy R

    2016-01-01

    The South Asian Monson (SAM) is one of the most intense climatic elements yet its initiation and variations are not well established. Dating the deposits of SAM wind-driven currents in IODP cores from the Maldives yields an age of 12. 9 Ma indicating an abrupt SAM onset, over a short period of 300 kyrs. This coincided with the Indian Ocean Oxygen Minimum Zone expansion as revealed by geochemical tracers and the onset of upwelling reflected by the sediment's content of particulate organic matter. A weaker 'proto-monsoon' existed between 12.9 and 25 Ma, as mirrored by the sedimentary signature of dust influx. Abrupt SAM initiation favors a strong influence of climate in addition to the tectonic control, and we propose that the post Miocene Climate Optimum cooling, together with increased continentalization and establishment of the bipolar ocean circulation, i.e. the beginning of the modern world, shifted the monsoon over a threshold towards the modern system. PMID:27436574

  18. Abrupt formation of isolated superconducting droplets in heavily disordered cuprates

    NASA Astrophysics Data System (ADS)

    Naqib, S. H.; Islam, R. S.

    2011-10-01

    The effect of controlled disorder on the superconducting transition temperature, Tc, resistivity, and the magnitude of the field-cooled ac susceptibility (ACS) has been investigated for Ca and Zn substituted Y123 (Y0.80Ca0.20Ba2(Cu1 - yZny)3O7 - δ) sintered compounds over a wide range of compositions. Ca was used to explore the overdoped side. The in-plane hole content, p, was changed by varying the oxygen deficiency (δ). Irrespective of the hole content, Tc decreased almost linearly with Zn, though the rate of suppression was strongly p dependent. The magnitude of the low-field, field-cooled ACS, on the other hand, decreased abruptly and significantly for the heavily disordered (y > 0.05) sintered compounds when p was decreased. More strikingly, the qualitative features of the field dependent ACS signal became identical for sintered and powdered samples, indicating a complete absence of coupling among superconducting grains in heavily disordered Y0.80Ca0.20Ba2(Cu1 - yZny)3O7 - δ. A non-monotonic and pronounced enhancement of the residual resistivity for samples with y > 0.05 lends further support to this picture. The abruptness of this 'isolated superconducting droplet' behavior points toward possible interplay among various length scales. We discuss the implications of these findings in detail in this paper.

  19. North Pacific deglacial hypoxic events linked to abrupt ocean warming.

    PubMed

    Praetorius, S K; Mix, A C; Walczak, M H; Wolhowe, M D; Addison, J A; Prahl, F G

    2015-11-19

    Marine sediments from the North Pacific document two episodes of expansion and strengthening of the subsurface oxygen minimum zone (OMZ) accompanied by seafloor hypoxia during the last deglacial transition. The mechanisms driving this hypoxia remain under debate. We present a new high-resolution alkenone palaeotemperature reconstruction from the Gulf of Alaska that reveals two abrupt warming events of 4-5 degrees Celsius at the onset of the Bølling and Holocene intervals that coincide with sudden shifts to hypoxia at intermediate depths. The presence of diatomaceous laminations and hypoxia-tolerant benthic foraminiferal species, peaks in redox-sensitive trace metals, and enhanced (15)N/(14)N ratio of organic matter, collectively suggest association with high export production. A decrease in (18)O/(16)O values of benthic foraminifera accompanying the most severe deoxygenation event indicates subsurface warming of up to about 2 degrees Celsius. We infer that abrupt warming triggered expansion of the North Pacific OMZ through reduced oxygen solubility and increased marine productivity via physiological effects; following initiation of hypoxia, remobilization of iron from hypoxic sediments could have provided a positive feedback on ocean deoxygenation through increased nutrient utilization and carbon export. Such a biogeochemical amplification process implies high sensitivity of OMZ expansion to warming. PMID:26581293

  20. Early warnings and missed alarms for abrupt monsoon transitions

    NASA Astrophysics Data System (ADS)

    Thomas, Z. A.; Kwasniok, F.; Boulton, C. A.; Cox, P. M.; Jones, R. T.; Lenton, T. M.; Turney, C. S. M.

    2015-04-01

    Palaeo-records from China (Cheng et al., 2009; Wang et al., 2008, 2001) demonstrate the East Asian Summer Monsoon (EASM) is dominated by abrupt and large magnitude monsoon shifts on millennial timescales, switching between periods of high and weak monsoon rains. It has been hypothesised that over these timescales, the EASM exhibits two stable states with bifurcation-type tipping points between them (Schewe et al., 2012). Here we test this hypothesis by looking for early warning signals of past bifurcations in speleothem records from Sanbao Cave and Hulu Cave, China (Wang et al., 2008, 2001), spanning the penultimate glacial cycle, and in multiple model simulations derived from the data. We find hysteresis behaviour in our model simulations with transitions directly forced by solar insolation. We detect critical slowing down prior to an abrupt monsoon shift during the penultimate deglaciation consistent with long-term orbital forcing. However, such signals are only detectable when the change in system stability is sufficiently slow to be detected by the sampling resolution of the dataset, raising the possibility that the alarm was missed and a similar forcing drove earlier EASM shifts.

  1. Early warnings and missed alarms for abrupt monsoon transitions

    NASA Astrophysics Data System (ADS)

    Thomas, Z. A.; Kwasniok, F.; Boulton, C. A.; Cox, P. M.; Jones, R. T.; Lenton, T. M.; Turney, C. S. M.

    2015-12-01

    Palaeo-records from China demonstrate that the East Asian Summer Monsoon (EASM) is dominated by abrupt and large magnitude monsoon shifts on millennial timescales, switching between periods of high and weak monsoon rains. It has been hypothesized that over these timescales, the EASM exhibits two stable states with bifurcation-type tipping points between them. Here we test this hypothesis by looking for early warning signals of past bifurcations in speleothem δ18O records from Sanbao Cave and Hulu Cave, China, spanning the penultimate glacial cycle. We find that although there are increases in both autocorrelation and variance preceding some of the monsoon transitions during this period, it is only immediately prior to the abrupt monsoon shift at the penultimate deglaciation (Termination II) that statistically significant increases are detected. To supplement our data analysis, we produce and analyse multiple model simulations that we derive from these data. We find hysteresis behaviour in our model simulations with transitions directly forced by solar insolation. However, signals of critical slowing down, which occur on the approach to a bifurcation, are only detectable in the model simulations when the change in system stability is sufficiently slow to be detected by the sampling resolution of the data set. This raises the possibility that the early warning "alarms" were missed in the speleothem data over the period 224-150 kyr and it was only at the monsoon termination that the change in the system stability was sufficiently slow to detect early warning signals.

  2. 9 CFR 325.18 - Diverting of shipments, breaking of seals, and reloading by carrier in emergency; reporting to...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... seals, and reloading by carrier in emergency; reporting to Regional Director. 325.18 Section 325.18... CERTIFICATION TRANSPORTATION § 325.18 Diverting of shipments, breaking of seals, and reloading by carrier in...) In case of wreck or similar extraordinary emergency, the Department seals on a railroad car or...

  3. 30 CFR 250.432 - How do I obtain a departure to diverter design and installation requirements?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... ENVIRONMENTAL ENFORCEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Drilling Operations Diverter System Requirements § 250.432 How do I obtain a... departures, you must have discussed the departure in your APD and received approval from the District...

  4. 9 CFR 325.18 - Diverting of shipments, breaking of seals, and reloading by carrier in emergency; reporting to...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... seals, and reloading by carrier in emergency; reporting to Regional Director. 325.18 Section 325.18... CERTIFICATION TRANSPORTATION § 325.18 Diverting of shipments, breaking of seals, and reloading by carrier in...) In case of wreck or similar extraordinary emergency, the Department seals on a railroad car or...

  5. 9 CFR 325.18 - Diverting of shipments, breaking of seals, and reloading by carrier in emergency; reporting to...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... seals, and reloading by carrier in emergency; reporting to Regional Director. 325.18 Section 325.18... CERTIFICATION TRANSPORTATION § 325.18 Diverting of shipments, breaking of seals, and reloading by carrier in...) In case of wreck or similar extraordinary emergency, the Department seals on a railroad car or...

  6. Median and Low-Flow Characteristics for Streams under Natural and Diverted Conditions, Northeast Maui, Hawaii

    USGS Publications Warehouse

    Gingerich, Stephen B.

    2005-01-01

    Flow-duration statistics under natural (undiverted) and diverted flow conditions were estimated for gaged and ungaged sites on 21 streams in northeast Maui, Hawaii. The estimates were made using the optimal combination of continuous-record gaging-station data, low-flow measurements, and values determined from regression equations developed as part of this study. Estimated 50- and 95-percent flow duration statistics for streams are presented and the analyses done to develop and evaluate the methods used in estimating the statistics are described. Estimated streamflow statistics are presented for sites where various amounts of streamflow data are available as well as for locations where no data are available. Daily mean flows were used to determine flow-duration statistics for continuous-record stream-gaging stations in the study area following U.S. Geological Survey established standard methods. Duration discharges of 50- and 95-percent were determined from total flow and base flow for each continuous-record station. The index-station method was used to adjust all of the streamflow records to a common, long-term period. The gaging station on West Wailuaiki Stream (16518000) was chosen as the index station because of its record length (1914-2003) and favorable geographic location. Adjustments based on the index-station method resulted in decreases to the 50-percent duration total flow, 50-percent duration base flow, 95-percent duration total flow, and 95-percent duration base flow computed on the basis of short-term records that averaged 7, 3, 4, and 1 percent, respectively. For the drainage basin of each continuous-record gaged site and selected ungaged sites, morphometric, geologic, soil, and rainfall characteristics were quantified using Geographic Information System techniques. Regression equations relating the non-diverted streamflow statistics to basin characteristics of the gaged basins were developed using ordinary-least-squares regression analyses. Rainfall

  7. Abrupt climate shift in the Western Mediterranean Sea

    PubMed Central

    Schroeder, K.; Chiggiato, J.; Bryden, H. L.; Borghini, M.; Ben Ismail, S.

    2016-01-01

    One century of oceanographic measurements has evidenced gradual increases in temperature and salinity of western Mediterranean water masses, even though the vertical stratification has basically remained unchanged. Starting in 2005, the basic structure of the intermediate and deep layers abruptly changed. We report here evidence of reinforced thermohaline variability in the deep western basin with significant dense water formation events producing large amounts of warmer, saltier and denser water masses than ever before. We provide a detailed chronological order to these changes, giving an overview of the new water masses and following their route from the central basin interior to the east (toward the Tyrrhenian) and toward the Atlantic Ocean. As a consequence of this climate shift, new deep waters outflowing through Gibraltar will impact the North Atlantic in terms of salt and heat input. In addition, modifications in the Mediterranean abyssal ecosystems and biogeochemical cycles are to be expected. PMID:26965790

  8. Abrupt rise of new machine ecology beyond human response time

    PubMed Central

    Johnson, Neil; Zhao, Guannan; Hunsader, Eric; Qi, Hong; Johnson, Nicholas; Meng, Jing; Tivnan, Brian

    2013-01-01

    Society's techno-social systems are becoming ever faster and more computer-orientated. However, far from simply generating faster versions of existing behaviour, we show that this speed-up can generate a new behavioural regime as humans lose the ability to intervene in real time. Analyzing millisecond-scale data for the world's largest and most powerful techno-social system, the global financial market, we uncover an abrupt transition to a new all-machine phase characterized by large numbers of subsecond extreme events. The proliferation of these subsecond events shows an intriguing correlation with the onset of the system-wide financial collapse in 2008. Our findings are consistent with an emerging ecology of competitive machines featuring ‘crowds' of predatory algorithms, and highlight the need for a new scientific theory of subsecond financial phenomena. PMID:24022120

  9. Abrupt Change 8200 Years Ago: The Smoking Gun?

    NASA Astrophysics Data System (ADS)

    Alley, R. B.

    2003-12-01

    The large, rapid, widespread climate change about 8200 years ago followed a large freshening of the North Atlantic Ocean, and produced climate anomalies in the Northern Hemisphere that are consistent with the expected response to North Atlantic cooling and that mimic the larger and longer-lasting effects of the Younger Dryas and older events. The short-lived nature of this Holocene event explains the lack of a signal at high southern latitudes, and the other features support the hypotheses that abrupt climate changes have been forced by North Atlantic freshening, and that Holocene warmth is not a guarantee of stability. Comparison of modeled and observed impacts of North Atlantic freshening suggests that some models are somewhat undersensitive compared to the real world.

  10. Abrupt tectonics and rapid slab detachment with grain damage.

    PubMed

    Bercovici, David; Schubert, Gerald; Ricard, Yanick

    2015-02-01

    A simple model for necking and detachment of subducting slabs is developed to include the coupling between grain-sensitive rheology and grain-size evolution with damage. Necking is triggered by thickened buoyant crust entrained into a subduction zone, in which case grain damage accelerates necking and allows for relatively rapid slab detachment, i.e., within 1 My, depending on the size of the crustal plug. Thick continental crustal plugs can cause rapid necking while smaller plugs characteristic of ocean plateaux cause slower necking; oceanic lithosphere with normal or slightly thickened crust subducts without necking. The model potentially explains how large plateaux or continental crust drawn into subduction zones can cause slab loss and rapid changes in plate motion and/or induce abrupt continental rebound. PMID:25605890

  11. Thunderstorm Ground Enhancements Abruptly Terminated by the Lightning Flash

    NASA Astrophysics Data System (ADS)

    Chilingarian, A. A.; Sogomonyan, S. B.

    2015-12-01

    Electrons giving rise to the Thunderstorm ground enhancements (TGEs) are accelerated in the lower dipole formed by the main negatively charged region in the middle of the cloud and the transient lower positively charged region (LPCR). The LPCR prevents the lightning leader from reaching the ground and usually no -CG lightning occurs during mature LPCR when the particle flux is sizable. Only after decaying of the LPCR lightning the stepped leader makes its path to the ground. Polarized water droplets also have a role in the TGE initiation. Our observations show that only at high humidity the TGEs at Aragats are possible and rains terminate the particle fluxes. We consider TGE events abruptly terminated by the lightning discharge. Proceeding from the large collection of the sharply stopped TGE events detected on Mt. Aragats we investigated how particle fluxes can help the stepped leader to reach the ground.

  12. Abrupt tectonics and rapid slab detachment with grain damage.

    PubMed

    Bercovici, David; Schubert, Gerald; Ricard, Yanick

    2015-02-01

    A simple model for necking and detachment of subducting slabs is developed to include the coupling between grain-sensitive rheology and grain-size evolution with damage. Necking is triggered by thickened buoyant crust entrained into a subduction zone, in which case grain damage accelerates necking and allows for relatively rapid slab detachment, i.e., within 1 My, depending on the size of the crustal plug. Thick continental crustal plugs can cause rapid necking while smaller plugs characteristic of ocean plateaux cause slower necking; oceanic lithosphere with normal or slightly thickened crust subducts without necking. The model potentially explains how large plateaux or continental crust drawn into subduction zones can cause slab loss and rapid changes in plate motion and/or induce abrupt continental rebound.

  13. Abrupt climate shift in the Western Mediterranean Sea.

    PubMed

    Schroeder, K; Chiggiato, J; Bryden, H L; Borghini, M; Ben Ismail, S

    2016-01-01

    One century of oceanographic measurements has evidenced gradual increases in temperature and salinity of western Mediterranean water masses, even though the vertical stratification has basically remained unchanged. Starting in 2005, the basic structure of the intermediate and deep layers abruptly changed. We report here evidence of reinforced thermohaline variability in the deep western basin with significant dense water formation events producing large amounts of warmer, saltier and denser water masses than ever before. We provide a detailed chronological order to these changes, giving an overview of the new water masses and following their route from the central basin interior to the east (toward the Tyrrhenian) and toward the Atlantic Ocean. As a consequence of this climate shift, new deep waters outflowing through Gibraltar will impact the North Atlantic in terms of salt and heat input. In addition, modifications in the Mediterranean abyssal ecosystems and biogeochemical cycles are to be expected. PMID:26965790

  14. Abrupt climate shift in the Western Mediterranean Sea

    NASA Astrophysics Data System (ADS)

    Schroeder, K.; Chiggiato, J.; Bryden, H. L.; Borghini, M.; Ben Ismail, S.

    2016-03-01

    One century of oceanographic measurements has evidenced gradual increases in temperature and salinity of western Mediterranean water masses, even though the vertical stratification has basically remained unchanged. Starting in 2005, the basic structure of the intermediate and deep layers abruptly changed. We report here evidence of reinforced thermohaline variability in the deep western basin with significant dense water formation events producing large amounts of warmer, saltier and denser water masses than ever before. We provide a detailed chronological order to these changes, giving an overview of the new water masses and following their route from the central basin interior to the east (toward the Tyrrhenian) and toward the Atlantic Ocean. As a consequence of this climate shift, new deep waters outflowing through Gibraltar will impact the North Atlantic in terms of salt and heat input. In addition, modifications in the Mediterranean abyssal ecosystems and biogeochemical cycles are to be expected.

  15. Abrupt tectonics and rapid slab detachment with grain damage

    PubMed Central

    Bercovici, David; Schubert, Gerald; Ricard, Yanick

    2015-01-01

    A simple model for necking and detachment of subducting slabs is developed to include the coupling between grain-sensitive rheology and grain-size evolution with damage. Necking is triggered by thickened buoyant crust entrained into a subduction zone, in which case grain damage accelerates necking and allows for relatively rapid slab detachment, i.e., within 1 My, depending on the size of the crustal plug. Thick continental crustal plugs can cause rapid necking while smaller plugs characteristic of ocean plateaux cause slower necking; oceanic lithosphere with normal or slightly thickened crust subducts without necking. The model potentially explains how large plateaux or continental crust drawn into subduction zones can cause slab loss and rapid changes in plate motion and/or induce abrupt continental rebound. PMID:25605890

  16. Abrupt glacial climate shifts controlled by ice sheet changes.

    PubMed

    Zhang, Xu; Lohmann, Gerrit; Knorr, Gregor; Purcell, Conor

    2014-08-21

    During glacial periods of the Late Pleistocene, an abundance of proxy data demonstrates the existence of large and repeated millennial-scale warming episodes, known as Dansgaard-Oeschger (DO) events. This ubiquitous feature of rapid glacial climate change can be extended back as far as 800,000 years before present (BP) in the ice core record, and has drawn broad attention within the science and policy-making communities alike. Many studies have been dedicated to investigating the underlying causes of these changes, but no coherent mechanism has yet been identified. Here we show, by using a comprehensive fully coupled model, that gradual changes in the height of the Northern Hemisphere ice sheets (NHISs) can alter the coupled atmosphere-ocean system and cause rapid glacial climate shifts closely resembling DO events. The simulated global climate responses--including abrupt warming in the North Atlantic, a northward shift of the tropical rainbelts, and Southern Hemisphere cooling related to the bipolar seesaw--are generally consistent with empirical evidence. As a result of the coexistence of two glacial ocean circulation states at intermediate heights of the ice sheets, minor changes in the height of the NHISs and the amount of atmospheric CO2 can trigger the rapid climate transitions via a local positive atmosphere-ocean-sea-ice feedback in the North Atlantic. Our results, although based on a single model, thus provide a coherent concept for understanding the recorded millennial-scale variability and abrupt climate changes in the coupled atmosphere-ocean system, as well as their linkages to the volume of the intermediate ice sheets during glacials.

  17. Low-latitude mountain glacier evidence for abrupt climate changes

    NASA Astrophysics Data System (ADS)

    Thompson, L. G.; Mosley-Thompson, E. S.; Lin, P.; Davis, M. E.; Mashiotta, T. A.; Brecher, H. H.

    2004-12-01

    Clear evidence that a widespread warming of Earth's climate system is now underway comes from low latitude mountain glaciers. Proxy temperature histories reconstructed from ice cores, and the rapidly accelerating loss of both the total ice area and ice volume on a near global scale suggest that these glaciers responding to increasing rates of melting. In situ observations reveal the startling rates at which many tropical glaciers are disappearing. For example, the retreat of the terminus of the Qori Kalis Glacier in Peru is roughly 200 meters per year, 40 times faster than its retreat rate in 1978. Similarly, in 1912 the ice on Mount Kilimanjaro covered 12.1 km2, but today it covers only 2.6 km2. If the current rate of retreat continues, the perennial ice fields may disappear within the next few decades, making this the first time in the past 11,700 years that Kilimanjaro will be devoid of the ice that shrouds its summit. Tropical glaciers may be considered ``the canaries in the coal mine'' for the global climate system as they integrate and respond to key climatological variables, such as temperature, precipitation, cloudiness, humidity, and incident solar radiation. A composite of the decadally-averaged oxygen isotopic records from three Andean and three Tibetan ice cores extending back over the last two millennia shows an isotopic enrichment in the 20th century that suggests a large-scale warming is underway at lower latitudes. Multiple lines of evidence from Africa, the Middle East, Europe and South America indicate an abrupt mid-Holocene climate event in the low latitudes. If such an event were to occur now with a global human population of 6.3 billion people, the consequences could be severe. Clearly, we need to understand the nature and cause of abrupt climate events.

  18. Abrupt glacial climate shifts controlled by ice sheet changes

    NASA Astrophysics Data System (ADS)

    Zhang, Xu; Lohmann, Gerrit; Knorr, Gregor; Purcell, Conor

    2014-08-01

    During glacial periods of the Late Pleistocene, an abundance of proxy data demonstrates the existence of large and repeated millennial-scale warming episodes, known as Dansgaard-Oeschger (DO) events. This ubiquitous feature of rapid glacial climate change can be extended back as far as 800,000 years before present (BP) in the ice core record, and has drawn broad attention within the science and policy-making communities alike. Many studies have been dedicated to investigating the underlying causes of these changes, but no coherent mechanism has yet been identified. Here we show, by using a comprehensive fully coupled model, that gradual changes in the height of the Northern Hemisphere ice sheets (NHISs) can alter the coupled atmosphere-ocean system and cause rapid glacial climate shifts closely resembling DO events. The simulated global climate responses--including abrupt warming in the North Atlantic, a northward shift of the tropical rainbelts, and Southern Hemisphere cooling related to the bipolar seesaw--are generally consistent with empirical evidence. As a result of the coexistence of two glacial ocean circulation states at intermediate heights of the ice sheets, minor changes in the height of the NHISs and the amount of atmospheric CO2 can trigger the rapid climate transitions via a local positive atmosphere-ocean-sea-ice feedback in the North Atlantic. Our results, although based on a single model, thus provide a coherent concept for understanding the recorded millennial-scale variability and abrupt climate changes in the coupled atmosphere-ocean system, as well as their linkages to the volume of the intermediate ice sheets during glacials.

  19. Abrupt glacial climate shifts controlled by ice sheet changes.

    PubMed

    Zhang, Xu; Lohmann, Gerrit; Knorr, Gregor; Purcell, Conor

    2014-08-21

    During glacial periods of the Late Pleistocene, an abundance of proxy data demonstrates the existence of large and repeated millennial-scale warming episodes, known as Dansgaard-Oeschger (DO) events. This ubiquitous feature of rapid glacial climate change can be extended back as far as 800,000 years before present (BP) in the ice core record, and has drawn broad attention within the science and policy-making communities alike. Many studies have been dedicated to investigating the underlying causes of these changes, but no coherent mechanism has yet been identified. Here we show, by using a comprehensive fully coupled model, that gradual changes in the height of the Northern Hemisphere ice sheets (NHISs) can alter the coupled atmosphere-ocean system and cause rapid glacial climate shifts closely resembling DO events. The simulated global climate responses--including abrupt warming in the North Atlantic, a northward shift of the tropical rainbelts, and Southern Hemisphere cooling related to the bipolar seesaw--are generally consistent with empirical evidence. As a result of the coexistence of two glacial ocean circulation states at intermediate heights of the ice sheets, minor changes in the height of the NHISs and the amount of atmospheric CO2 can trigger the rapid climate transitions via a local positive atmosphere-ocean-sea-ice feedback in the North Atlantic. Our results, although based on a single model, thus provide a coherent concept for understanding the recorded millennial-scale variability and abrupt climate changes in the coupled atmosphere-ocean system, as well as their linkages to the volume of the intermediate ice sheets during glacials. PMID:25119027

  20. Correlation between Hemodynamics and Treatment Outcome of Intracranial Aneurysms after Intervention with Flow Diverters

    NASA Astrophysics Data System (ADS)

    Paliwal, Nikhil; Damiano, Robert; Davies, Jason; Siddiqui, Adnan; Meng, Hui

    2015-11-01

    Endovascular intervention by Flow Diverter (FD) - a densely woven stent - occludes an aneurysm by inducing thrombosis in the aneurysm sac and reconstructing the vessel. Hemodynamics plays a vital role in the thrombotic occlusion of aneurysms and eventual treatment outcome. CFD analysis of pre- and post-treatment aneurysms not only provides insight of flow modifications by FD, but also allows investigation of interventional strategies and prediction of their outcome. In this study 80 patient-specific aneurysms treated with FDs were retrospectively studied to evaluate the effect of intervention. Out of these cases, 16 required retreatment and thus are considered as having unfavorable outcome. Clinical FD deployment in these cases was simulated using an efficient virtual stenting workflow. CFD analysis was carried out on both pre- and post-treatment cases, and changes in hemodynamic parameters were calculated. Support vector machine algorithm was used to correlate the hemodynamic changes with outcome. Results show that cases having higher flow reduction into the aneurysmal sac have a better likelihood of occlusion. This suggests that changes in hemodynamics can be potentially used to predict the outcome of different clinical intervention strategies in aneurysms. This work was supported by the National Institutes of Health (R01 NS091075).

  1. Experimental investigation of plasma flows in open trap with toroidal diverter under ECR discharge

    SciTech Connect

    Berezkin, A. V. Bragin, E. Yu. Zhil’tsov, V. A. Kulygin, V. M. Yanchenkov, S. V.

    2015-12-15

    The results of experimental investigations of plasma flows from an open trap with a toroidal diverter are presented. Cold plasma is generated when introducing microwave power under conditions of electron cyclotron resonance (ECR). The radiation is introduced by a waveguide through a vacuum-tight ceramic window across the axis of the device. By means of the Langmuir probes, the spatial distributions of plasma parameters are measured. The highest density is limited to a critical value n{sub c} (∼10{sup 12} cm{sup –3}) for the generator frequency under use. It is found that the temperature and density of the plasma in the trap and in escaping flows are almost independent of the radius when the ECR zone is located near the open-trap confinement region and the density is close to n{sub c}. At the density n < n{sub c}, ring plasma structures, which collapse under the action of a low-frequency instability, are observed near the separatrix. The possible mechanisms of the occurrence of plasma structures and the nature of the plasma streams are discussed.

  2. BIM Deficiency Protects NOD Mice From Diabetes by Diverting Thymocytes to Regulatory T Cells.

    PubMed

    Krishnamurthy, Balasubramanian; Chee, Jonathan; Jhala, Gaurang; Trivedi, Prerak; Catterall, Tara; Selck, Claudia; Gurzov, Esteban N; Brodnicki, Thomas C; Graham, Kate L; Wali, Jibran A; Zhan, Yifan; Gray, Daniel; Strasser, Andreas; Allison, Janette; Thomas, Helen E; Kay, Thomas W H

    2015-09-01

    Because regulatory T-cell (Treg) development can be induced by the same agonist self-antigens that induce negative selection, perturbation of apoptosis will affect both negative selection and Treg development. But how the processes of thymocyte deletion versus Treg differentiation bifurcate and their relative importance for tolerance have not been studied in spontaneous organ-specific autoimmune disease. We addressed these questions by removing a critical mediator of thymocyte deletion, BIM, in the NOD mouse model of autoimmune diabetes. Despite substantial defects in the deletion of autoreactive thymocytes, BIM-deficient NOD (NODBim(-/-)) mice developed less insulitis and were protected from diabetes. BIM deficiency did not impair effector T-cell function; however, NODBim(-/-) mice had increased numbers of Tregs, including those specific for proinsulin, in the thymus and peripheral lymphoid tissues. Increased levels of Nur77, CD5, GITR, and phosphorylated IκB-α in thymocytes from NODBim(-/-) mice suggest that autoreactive cells receiving strong T-cell receptor signals that would normally delete them escape apoptosis and are diverted into the Treg pathway. Paradoxically, in the NOD model, reduced thymic deletion ameliorates autoimmune diabetes by increasing Tregs. Thus, modulating apoptosis may be one of the ways to increase antigen-specific Tregs and prevent autoimmune disease.

  3. BIM Deficiency Protects NOD Mice From Diabetes by Diverting Thymocytes to Regulatory T Cells.

    PubMed

    Krishnamurthy, Balasubramanian; Chee, Jonathan; Jhala, Gaurang; Trivedi, Prerak; Catterall, Tara; Selck, Claudia; Gurzov, Esteban N; Brodnicki, Thomas C; Graham, Kate L; Wali, Jibran A; Zhan, Yifan; Gray, Daniel; Strasser, Andreas; Allison, Janette; Thomas, Helen E; Kay, Thomas W H

    2015-09-01

    Because regulatory T-cell (Treg) development can be induced by the same agonist self-antigens that induce negative selection, perturbation of apoptosis will affect both negative selection and Treg development. But how the processes of thymocyte deletion versus Treg differentiation bifurcate and their relative importance for tolerance have not been studied in spontaneous organ-specific autoimmune disease. We addressed these questions by removing a critical mediator of thymocyte deletion, BIM, in the NOD mouse model of autoimmune diabetes. Despite substantial defects in the deletion of autoreactive thymocytes, BIM-deficient NOD (NODBim(-/-)) mice developed less insulitis and were protected from diabetes. BIM deficiency did not impair effector T-cell function; however, NODBim(-/-) mice had increased numbers of Tregs, including those specific for proinsulin, in the thymus and peripheral lymphoid tissues. Increased levels of Nur77, CD5, GITR, and phosphorylated IκB-α in thymocytes from NODBim(-/-) mice suggest that autoreactive cells receiving strong T-cell receptor signals that would normally delete them escape apoptosis and are diverted into the Treg pathway. Paradoxically, in the NOD model, reduced thymic deletion ameliorates autoimmune diabetes by increasing Tregs. Thus, modulating apoptosis may be one of the ways to increase antigen-specific Tregs and prevent autoimmune disease. PMID:25948683

  4. Diverting colostomy induces mucosal and muscular atrophy in rat distal colon.

    PubMed Central

    Kissmeyer-Nielsen, P; Christensen, H; Laurberg, S

    1994-01-01

    The progress of adaptive changes in the left colon after diverting colostomy was studied in rats using stereological techniques. Standardised segments of left colon proximal and distal to the colostomy was examined after 0, 1, 2, 4, or 12 weeks. In excluded colon the mucosal weight was reduced by 37% (p < 0.01) and the luminal surface area by 47% (p < 0.01) after four weeks and reached a steady state at this point of time, as no further reduction was seen from 4 to 12 weeks. The number of proliferating crypt cells was determined immunohistochemically after in vivo labelling with bromodeoxyuridine and was compared with the total number of colonocytes. Total bowel rest leads to a reduction in the number of proliferating epithelial cells and not to a reduced average life span. The weight of the muscularis propria decreased by 32% after four weeks (p < 0.01) and by 48% after 12 weeks (p < 0.001), whereas the weight of the submucosa was unchanged. No adaptive changes were found in segments proximal to the colostomy. These results show that the wall composition of defunctioned colon in rats is radically changed resulting from a mucosal and muscular atrophy, and from a reduction in luminal surface area. Images Figure 2 Figure 3 Figure 4 PMID:7959237

  5. Measurement of flow diverter hydraulic resistance to model flow modification in and around intracranial aneurysms

    PubMed Central

    Szikora, István; Paál, György

    2014-01-01

    Flow diverters (FDs) have been successfully applied in the recent decade to the treatment of intracranial aneurysms by impairing the communication between the flows in the parent artery and the aneurysm and, thus, the blood within the aneurysm sac. It would be desirable to have a simple and accurate computational method to follow the changes in the peri- and intraaneurysmal flow caused by the presence of FDs. The detailed flow simulation around the intricate wire structure of the FDs has three disadvantages: need for high amount of computational resources and highly skilled professionals to prepare the computational grid, and also the lack of validation that makes the invested effort questionable. In this paper, we propose a porous layer method to model the hydraulic resistance (HR) of one or several layers of the FDs. The basis of this proposal is twofold: first, from an application point of view, the only interesting parameter regarding the function of the FD is its HR; second, we have developed a method to measure the HR with a simple apparatus. We present the results of these measurements and demonstrate their utility in numerical simulations of patient-specific aneurysm simulations. PMID:24936307

  6. A new flow diverter stent for direct treatment of intracranial aneurysm.

    PubMed

    Ma, Jiayao; You, Zhong; Peach, Thomas; Byrne, James; Rizkallah, Rafik R

    2015-12-16

    The use of a stand-alone flow diverter (FD) stent has demonstrated itself as an efficacious endovascular approach to intracranial aneurysm treatment. FD stents that are currently available adopt an interwoven braided design. The relatively low radial stiffness intrinsic to this design could cause difficulty in deployment and poor stent-wall apposition, leading to high complication rates. A new FD stent is proposed to overcome the problems of the interwoven FD stents. The new device is manufactured from a Nitinol tube through a laser-cutting technique, and its unique structure allows for both low porosity and high packaging efficiency. Computational simulation using Abaqus has been conducted to investigate the radial stiffness and longitudinal flexibility of the new device. The new device exhibits high radial stiffness when compared to interwoven FD stents and superior longitudinal flexibility. Results from on-going in-vivo experiments and CFD simulations have also demonstrated the efficacy of the new device as a FD stent. PMID:26592434

  7. Abrupt reversal in emissions and atmospheric abundance of HCFC-133a (CF3CH2Cl)

    NASA Astrophysics Data System (ADS)

    Vollmer, Martin K.; Rigby, Matt; Laube, Johannes C.; Henne, Stephan; Rhee, Tae Siek; Gooch, Lauren J.; Wenger, Angelina; Young, Dickon; Steele, L. Paul; Langenfelds, Ray L.; Brenninkmeijer, Carl A. M.; Wang, Jia-Lin; Ou-Yang, Chang-Feng; Wyss, Simon A.; Hill, Matthias; Oram, David E.; Krummel, Paul B.; Schoenenberger, Fabian; Zellweger, Christoph; Fraser, Paul J.; Sturges, William T.; O'Doherty, Simon; Reimann, Stefan

    2015-10-01

    Hydrochlorofluorocarbon HCFC-133a (CF3CH2Cl) is an anthropogenic compound whose consumption for emissive use is restricted under the Montreal Protocol. A recent study showed rapidly increasing atmospheric abundances and emissions. We report that, following this rise, the atmospheric abundance and emissions have declined sharply in the past three years. We find a Northern Hemisphere HCFC-133a increase from 0.13 ppt (dry-air mole fraction in parts per trillion) in 2000 to 0.50 ppt in 2012-mid-2013 followed by an abrupt drop to ˜0.44 ppt by early 2015. Global emissions derived from these observations peaked at 3.1 kt in 2011, followed by a rapid decline of ˜0.5 kt yr-2 to reach 1.5 kt yr-1 in 2014. Sporadic HCFC-133a pollution events are detected in Europe from our high-resolution HCFC-133a records at three European stations, and in Asia from samples collected in Taiwan. European emissions are estimated to be <0.1 kt yr-1 although emission hot spots were identified in France.

  8. Abrupt shifts in Horn of Africa hydroclimate since the Last Glacial Maximum.

    PubMed

    Tierney, Jessica E; deMenocal, Peter B

    2013-11-15

    The timing and abruptness of the initiation and termination of the Early Holocene African Humid Period are subjects of ongoing debate, with direct consequences for our understanding of abrupt climate change, paleoenvironments, and early human cultural development. Here, we provide proxy evidence from the Horn of Africa region that documents abrupt transitions into and out of the African Humid Period in northeast Africa. Similar and generally synchronous abrupt transitions at other East African sites suggest that rapid shifts in hydroclimate are a regionally coherent feature. Our analysis suggests that the termination of the African Humid Period in the Horn of Africa occurred within centuries, underscoring the nonlinearity of the region's hydroclimate. PMID:24114782

  9. Abrupt Atmospheric Methane Increases Associated With Hudson Strait Heinrich Events

    NASA Astrophysics Data System (ADS)

    Rhodes, R.; Brook, E.; Chiang, J. C. H.; Blunier, T.; Maselli, O. J.; McConnell, J. R.; Romanini, D.; Severinghaus, J. P.

    2015-12-01

    The drivers of abrupt climate change during the Last Glacial Period are not well understood. While Dansgaard-Oeschger (DO) cycles are thought to be linked to variations in the strength of the Atlantic Meridional Ocean Circulation (AMOC), it is not clear how or if Heinrich Events—extensive influxes of icebergs into the North Atlantic Ocean that impacted global climate and biogeochemistry—are related. An enduring problem is the difficultly in dating iceberg rafted debris deposits that typically lack foraminifera. Here we present an ultra-high resolution record of methane from the West Antarctic Ice Sheet Divide ice core at unprecedented, continuous temporal resolution from 67.2-9.8 ka BP, which we propose constrains the timing of Heinrich events. Our methane record essentially mirrors Greenland ice core stable isotope variability across D-O events, except during Heinrich stadials 1, 2, 4 and 5. Partway through these stadials only, methane increases abruptly and rapidly, as at the onset of a D-O event but Greenland temperature exhibits no equivalent response. Speleothem records exhibit signatures of drought in the Northern extra-tropics and intensified monsoonal activity over South America at these times. We use a simple heuristic model to propose that cold air temperatures and extensive sea ice in the North, resulting from Heinrich events, caused extreme reorganization of tropical hydroclimate. This involved curtailment of the seasonal northerly migration of tropical rain belts, leading to intensification of rainfall over Southern Hemisphere tropical wetlands, thus allowing production of excess methane relative to a 'normal' Greenland stadial. We note that this mechanism can operate if AMOC is already in a slowed state when a Heinrich event occurs, as paleo-evidence suggests it was. Heinrich events and associated sea ice cover would therefore act to prolong the duration of this AMOC state. Our findings place the big four Heinrich events of Hudson Strait origin

  10. Flow diverter as a rescue therapy for a complicated basilar angioplasty.

    PubMed

    Velioglu, Murat; Ozturk, Ersin; Sonmez, Guner; Kendirli, Tansel; Mutlu, Hakan; Basekim, Cinar

    2013-01-01

    Intracranial atherosclerotic disease is a major cause of ischemic stroke. Stenting and aggressive medical management for preventing recurrent stroke in intracranial stenosis was terminated prematurely due to a high stroke and death rate in patients randomized for intracranial stent placement. However, for some patients, angioplasty and/or stent placement remains the best approach. Flow diverters (FDs) are designed to produce a hemodynamic flow diversion by constituting a laminar flow pattern in the parent artery and are mainly used in non-ruptured complex wide-neck aneurysms as well as in ruptured aneurysms. Herein, we present a case where an FD was used in a complicated angioplasty for basilar artery atherosclerosis. A 72-year-old female patient was admitted to our hospital with left side weakness and vertigo. Her diffusion magnetic resonance imaging and magnetic resonance angiography showed right-sided pontine and left-sided occipital acute infarcts with left-sided pontine and right-sided occipital chronic infarcted areas and preocclusive mid-basilar stenosis. The patient was under supervised medical treatment. Despite chronic brain stem and occipital infarcts her modified Rankin Scale was 2. Diagnostic angiography showed no posterior communicating arteries and no pial-pial collaterals and a critical mid-basilar artery stenosis. We decided to perform intracranial angioplasty to increase the perfusion of posterior circulation and reduce the risk of additional embolic infarcts. Angioplasty was complicated with dissection and vessel perforation. We used an FD for rescue therapy to avoid rebleeding. The patient was discharged with good clinical and angiographic results.

  11. Survey of attitudes and perceptions of urine-diverting toilets and human waste recycling in Hawaii.

    PubMed

    Lamichhane, Krishna M; Babcock, Roger W

    2013-01-15

    Urine constitutes only about 1% of domestic sewage but contains 50% or more of the excreted nutrients and chemicals like hormones and pharmaceutical residues. Urine diverting toilet (UDT) systems can be considered a more sustainable alternative to wastewater management because they allow nutrient recycling, reduce water use, and allow source-separation of hormones and chemicals that can harm the environment. An online survey was conducted to determine whether UDTs are acceptable to the general public in Hawaii and if attitudes and perceptions towards it and human waste (HW) recycling vary with age, sex, level of education, religious affiliation, ethnicity, and employment status. The survey was also intended to detect possible drivers and barriers for the UDTs. Variations on variables were tested at 5% significance (p=0.05) level (Chi-squared test or ANOVA) and considered significantly different if the p-value was less than 0.05. The results were encouraging as more than 60% are willing to pay extra for the UDT, while only 22% knew that such systems existed. No statistically significant difference was found between males and females on all survey questions at the 5% level. However, females had higher willingness to pay (WTP) than males and WTP increased with age and income. The WTP of Caucasians was higher than Asians and differed significantly. Some respondents expressed concern about the legal provisions for recycling of HW. The survey results indicate that with a public education program, it is possible that most people would be willing to adopt UDTs and HW recycling with incurred societal benefits of reduced water and fertilizer use, reduced greenhouse gas emissions, and collection of micropollutants at the source to prevent their entry into waterways. Because of the small sample size (N=132, 13% response rate) the survey is not representative but may be indicative of the general attitude of Hawaiian people. PMID:23228720

  12. A transmission/escape probabilities model for neutral particle transport in the outer regions of a diverted tokamak

    SciTech Connect

    Stacey, W.M.

    1992-12-01

    A new computational model for neutral particle transport in the outer regions of a diverted tokamak plasma chamber is presented. The model is based on the calculation of transmission and escape probabilities using first-flight integral transport theory and the balancing of fluxes across the surfaces bounding the various regions. The geometrical complexity of the problem is included in precomputed probabilities which depend only on the mean free path of the region.

  13. Flow-Diverter Stent for the Treatment of a Non-Origin Posterior Inferior Cerebellar Artery Aneurysm

    PubMed Central

    Alokaili, Riyadh Nasser; Ahmed, Muhammad Ejaz

    2014-01-01

    Summary We describe the case of a 44-year old man with a ruptured wide-necked non-origin aneurysm of the posterior inferior cerebellar artery successfully treated with placement of a low porosity stent. To our knowledge, there are no cases in the literature of a non-origin posterior inferior cerebellar artery aneurysm treated with a flow-diverter stent. PMID:25196620

  14. Towards Predicting Patient-Specific Flow-Diverter Treatment Outcomes for Bifurcation Aneurysms: From Implantation Rehearsal to Virtual Angiograms.

    PubMed

    Peach, T W; Spranger, K; Ventikos, Y

    2016-01-01

    Despite accounting for the majority of all cerebral aneurysm cases, bifurcation aneurysms present many challenges to standard endovascular treatment techniques. This study examines the treatment of bifurcation aneurysms endovascularly with flow-diverting stents and presents an integrative computational modeling suite allowing for rehearsing all aspects of the treatment. Six bifurcation aneurysms are virtually treated with 70% porosity flow-diverters. Substantial reduction (>50%) in aneurysm inflow due to device deployment is predicted in addition to reductions in peak and average aneurysm wall shear stress to values considered physiologically normal. The subsequent impact of flow-diverter deployment on daughter vessels that are jailed by the device is investigated further, with a number of simulations conducted with increased outlet pressure conditions at jailed vessels. Increased outlet pressures at jailed daughter vessels are found to have little effect on device-induced aneurysm inflow reduction, but large variation (13-86%) is seen in the resulting reduction in daughter vessel flow rate. Finally, we propose a potentially powerful approach for validation of such models, by introducing an angiographic contrast model, with contrast transport modeled both before and after virtual treatment. Virtual angiograms and contrast residence curves are created, which offer unique clinical relevance and the potential for future in vivo verification of simulated results.

  15. Analysis and Design of a Double-Divert Spiral Groove Seal

    NASA Technical Reports Server (NTRS)

    Zheng, Xiaoqing; Berard, Gerald

    2007-01-01

    This viewgraph presentation describes the design and analysis of a double spiral groove seal. The contents include: 1) Double Spiral Design Features; 2) Double Spiral Operational Features; 3) Mating Ring/Rotor Assembly; 4) Seal Ring Assembly; 5) Insert Segment Joints; 6) Rotor Assembly Completed Prototype Parts; 7) Seal Assembly Completed Prototype Parts; 8) Finite Element Analysis; 9) Computational Fluid Dynamics (CFD) Analysis; 10) Restrictive Orifice Design; 11) Orifice CFD Model; 12) Orifice Results; 13) Restrictive Orifice; 14) Seal Face Coning; 15) Permanent Magnet Analysis; 16) Magnetic Repulsive Force; 17) Magnetic Repulsive Test Results; 18) Spin Testing; and 19) Testing and Validation.

  16. Anticipating abrupt shifts in temporal evolution of probability of eruption

    NASA Astrophysics Data System (ADS)

    Rohmer, Jeremy; Loschetter, Annick

    2016-04-01

    Estimating the probability of eruption by jointly accounting for different sources of monitoring parameters over time is a key component for volcano risk management. In the present study, we are interested in the transition from a state of low-to-moderate probability value and to the one of high probability value: the latter value generally supports the call for evacuation. By using the data of MESIMEX exercise at the Vesuvius volcano, we investigated the potential for time-varying indicators related to the correlation structure or to the variability of the probability time series for detecting in advance this critical transition. We found that changes in the power spectra and in the standard deviation estimated over a rolling time window both present an abrupt increase, which marks the approaching shift. Our numerical experiments revealed that the transition from an eruption probability of 10-15% to >70% could be identified up 4 hours in advance, ~2.5 days before the evacuation call (decided for an eruption probability >80% during the MESIMEX exercise). This additional lead time could be useful to place different key services (e.g., emergency services for vulnerable groups, commandeering additional transportation means, etc.) on a higher level of alert before the actual call for evacuation.

  17. Anticipating abrupt shifts in temporal evolution of probability of eruption

    NASA Astrophysics Data System (ADS)

    Rohmer, J.; Loschetter, A.

    2016-04-01

    Estimating the probability of eruption by jointly accounting for different sources of monitoring parameters over time is a key component for volcano risk management. In the present study, we are interested in the transition from a state of low-to-moderate probability value to a state of high probability value. By using the data of MESIMEX exercise at the Vesuvius volcano, we investigated the potential for time-varying indicators related to the correlation structure or to the variability of the probability time series for detecting in advance this critical transition. We found that changes in the power spectra and in the standard deviation estimated over a rolling time window both present an abrupt increase, which marks the approaching shift. Our numerical experiments revealed that the transition from an eruption probability of 10-15% to > 70% could be identified up to 1-3 h in advance. This additional lead time could be useful to place different key services (e.g., emergency services for vulnerable groups, commandeering additional transportation means, etc.) on a higher level of alert before the actual call for evacuation.

  18. Abrupt climate change and the decline of Indus urbanism

    NASA Astrophysics Data System (ADS)

    Hodell, D. A.; Dixit, Y.; Petrie, C. A.

    2012-12-01

    Climate change has been suggested as a cause for the decline of the cities of the Indus Civilization, which is believed to have begun ~4.0 to 3.9 ky B.P. Previous studies have centered on paleoclimatic records obtained from areas outside the geographic limits of the Indus Civilization, raising questions about their suitability for evaluating past climate-cultural linkages. Here we report a detailed climate record from paleolake Kotla Dahar, Haryana (28°00'095'' N, 76°57'173'' E), located at the eastern edge of the distribution of Indus settlements and ~100km to the east of the city-site of Rakhigarhi in NW India. Regional hydrologic changes are inferred using oxygen-isotope measurements of gastropod aragonite from a 2.88-m sediment section. A permanent ~4‰ increase in δ18O of shell aragonite occurred at ~4.1±0.1 ky B.P., marking an abrupt increase in evaporation/precipitation in the lake catchment. These data provide evidence for a weakening of the monsoon and shift toward drier climate on the plains of northwest (NW) India at ~4.1±0.1 ky B.P. Decreased monsoon rainfall at this time may have been linked to increased ENSO variability, and supports a possible role of climate in the transformation of the Indus Civilization from an urbanized (mature or urban Indus) to a rural (post-urban) society.

  19. Dynamic response of desert wetlands to abrupt climate change

    PubMed Central

    Springer, Kathleen B.; Manker, Craig R.; Pigati, Jeffrey S.

    2015-01-01

    Desert wetlands are keystone ecosystems in arid environments and are preserved in the geologic record as groundwater discharge (GWD) deposits. GWD deposits are inherently discontinuous and stratigraphically complex, which has limited our understanding of how desert wetlands responded to past episodes of rapid climate change. Previous studies have shown that wetlands responded to climate change on glacial to interglacial timescales, but their sensitivity to short-lived climate perturbations is largely unknown. Here, we show that GWD deposits in the Las Vegas Valley (southern Nevada, United States) provide a detailed and nearly complete record of dynamic hydrologic changes during the past 35 ka (thousands of calibrated 14C years before present), including cycles of wetland expansion and contraction that correlate tightly with climatic oscillations recorded in the Greenland ice cores. Cessation of discharge associated with rapid warming events resulted in the collapse of entire wetland systems in the Las Vegas Valley at multiple times during the late Quaternary. On average, drought-like conditions, as recorded by widespread erosion and the formation of desert soils, lasted for a few centuries. This record illustrates the vulnerability of desert wetland flora and fauna to abrupt climate change. It also shows that GWD deposits can be used to reconstruct paleohydrologic conditions at millennial to submillennial timescales and informs conservation efforts aimed at protecting these fragile ecosystems in the face of anthropogenic warming. PMID:26554007

  20. Abrupt drainage cycles of the Fennoscandian Ice Sheet

    PubMed Central

    Soulet, Guillaume; Ménot, Guillemette; Bayon, Germain; Rostek, Frauke; Ponzevera, Emmanuel; Toucanne, Samuel; Lericolais, Gilles; Bard, Edouard

    2013-01-01

    Continental ice sheets are a key component of the Earth’s climate system, but their internal dynamics need to be further studied. Since the last deglaciation, the northern Eurasian Fennoscandian Ice Sheet (FIS) has been connected to the Black Sea (BS) watershed, making this basin a suitable location to investigate former ice-sheet dynamics. Here, from a core retrieved in the BS, we combine the use of neodymium isotopes, high-resolution elemental analysis, and biomarkers to trace changes in sediment provenance and river runoff. We reveal cyclic releases of meltwater originating from Lake Disna, a proglacial lake linked to the FIS during Heinrich Stadial 1. Regional interactions within the climate–lake–FIS system, linked to changes in the availability of subglacial water, led to abrupt drainage cycles of the FIS into the BS watershed. This phenomenon raised the BS water level by ∼100 m until the sill of the Bosphorus Strait was reached, flooding the vast northwestern BS shelf and deeply affecting the hydrology and circulation of the BS and, probably, of the Marmara and Aegean Seas. PMID:23569264

  1. Climate oscillations and abrupt changes in C14 data

    NASA Astrophysics Data System (ADS)

    Kuznetsova, T. V.; Tsirulnik, L. B.

    2004-01-01

    The radiocarbon series are analysed by a method of non-linear spectral analysis to detect time intervals of appearance of non-stationary oscillations of large amplitude, and the times of abrupt changes of their oscillation regime. The analysis shows that the most powerful cycles of the spectra can be interpreted in terms of periods (and their respective higher harmonics) of astronomical origin. An intense stationary sinusoid from the spectrum with period T˜6500 yr, the 4th harmonic of the period of equinox precession, correlates with the time variations of the geomagnetic dipole moment. The most powerful non-stationary sinusoid with mean period T=2230 yr, reflects oscillations in C14 data related to the non-dipole part of the geomagnetic field, and correlates with periods of climate warming/cooling. The apparent regularities that can be inferred in the interaction of such two powerful cycles (i.e. stationary and non-stationary parts of the uniform mechanism of the geomagnetic field generation) permit to forecast a tendency of the climate changes. A possible physical mechanism is presented based on a possible transformation, of some signals caused by perturbation of the tidal forces of astronomical origin (that can arise along the orbit of the Earth), into effects that control geophysical systems through small variations of the dissipative parameters of a dynamo system.

  2. Detecting and isolating abrupt changes in linear switching systems

    NASA Astrophysics Data System (ADS)

    Nazari, Sohail; Zhao, Qing; Huang, Biao

    2015-04-01

    In this paper, a novel fault detection and isolation (FDI) method for switching linear systems is developed. All input and output signals are assumed to be corrupted with measurement noises. In the proposed method, a 'lifted' linear model named as stochastic hybrid decoupling polynomial (SHDP) is introduced. The SHDP model governs the dynamics of the switching linear system with all different modes, and is independent of the switching sequence. The error-in-variable (EIV) representation of SHDP is derived, and is used for the fault residual generation and isolation following the well-adopted local approach. The proposed FDI method can detect and isolate the fault-induced abrupt changes in switching models' parameters without estimating the switching modes. Furthermore, in this paper, the analytical expressions of the gradient vector and Hessian matrix are obtained based on the EIV SHDP formulation, so that they can be used to implement the online fault detection scheme. The performance of the proposed method is then illustrated by simulation examples.

  3. Abrupt Schottky Junctions in Al/Ge Nanowire Heterostructures

    PubMed Central

    2015-01-01

    In this Letter we report on the exploration of axial metal/semiconductor (Al/Ge) nanowire heterostructures with abrupt interfaces. The formation process is enabled by a thermal induced exchange reaction between the vapor–liquid–solid grown Ge nanowire and Al contact pads due to the substantially different diffusion behavior of Ge in Al and vice versa. Temperature-dependent I–V measurements revealed the metallic properties of the crystalline Al nanowire segments with a maximum current carrying capacity of about 0.8 MA/cm2. Transmission electron microscopy (TEM) characterization has confirmed both the composition and crystalline nature of the pure Al nanowire segments. A very sharp interface between the ⟨111⟩ oriented Ge nanowire and the reacted Al part was observed with a Schottky barrier height of 361 meV. To demonstrate the potential of this approach, a monolithic Al/Ge/Al heterostructure was used to fabricate a novel impact ionization device. PMID:26052733

  4. Dynamic response of desert wetlands to abrupt climate change.

    PubMed

    Springer, Kathleen B; Manker, Craig R; Pigati, Jeffrey S

    2015-11-24

    Desert wetlands are keystone ecosystems in arid environments and are preserved in the geologic record as groundwater discharge (GWD) deposits. GWD deposits are inherently discontinuous and stratigraphically complex, which has limited our understanding of how desert wetlands responded to past episodes of rapid climate change. Previous studies have shown that wetlands responded to climate change on glacial to interglacial timescales, but their sensitivity to short-lived climate perturbations is largely unknown. Here, we show that GWD deposits in the Las Vegas Valley (southern Nevada, United States) provide a detailed and nearly complete record of dynamic hydrologic changes during the past 35 ka (thousands of calibrated (14)C years before present), including cycles of wetland expansion and contraction that correlate tightly with climatic oscillations recorded in the Greenland ice cores. Cessation of discharge associated with rapid warming events resulted in the collapse of entire wetland systems in the Las Vegas Valley at multiple times during the late Quaternary. On average, drought-like conditions, as recorded by widespread erosion and the formation of desert soils, lasted for a few centuries. This record illustrates the vulnerability of desert wetland flora and fauna to abrupt climate change. It also shows that GWD deposits can be used to reconstruct paleohydrologic conditions at millennial to submillennial timescales and informs conservation efforts aimed at protecting these fragile ecosystems in the face of anthropogenic warming. PMID:26554007

  5. Dynamic response of desert wetlands to abrupt climate change

    USGS Publications Warehouse

    Springer, Kathleen; Manker, Craig; Pigati, Jeff

    2015-01-01

    Desert wetlands are keystone ecosystems in arid environments and are preserved in the geologic record as groundwater discharge (GWD) deposits. GWD deposits are inherently discontinuous and stratigraphically complex, which has limited our understanding of how desert wetlands responded to past episodes of rapid climate change. Previous studies have shown that wetlands responded to climate change on glacial to interglacial timescales, but their sensitivity to short-lived climate perturbations is largely unknown. Here, we show that GWD deposits in the Las Vegas Valley (southern Nevada, United States) provide a detailed and nearly complete record of dynamic hydrologic changes during the past 35 ka (thousands of calibrated 14C years before present), including cycles of wetland expansion and contraction that correlate tightly with climatic oscillations recorded in the Greenland ice cores. Cessation of discharge associated with rapid warming events resulted in the collapse of entire wetland systems in the Las Vegas Valley at multiple times during the late Quaternary. On average, drought-like conditions, as recorded by widespread erosion and the formation of desert soils, lasted for a few centuries. This record illustrates the vulnerability of desert wetland flora and fauna to abrupt climate change. It also shows that GWD deposits can be used to reconstruct paleohydrologic conditions at millennial to submillennial timescales and informs conservation efforts aimed at protecting these fragile ecosystems in the face of anthropogenic warming.

  6. Dynamic response of desert wetlands to abrupt climate change.

    PubMed

    Springer, Kathleen B; Manker, Craig R; Pigati, Jeffrey S

    2015-11-24

    Desert wetlands are keystone ecosystems in arid environments and are preserved in the geologic record as groundwater discharge (GWD) deposits. GWD deposits are inherently discontinuous and stratigraphically complex, which has limited our understanding of how desert wetlands responded to past episodes of rapid climate change. Previous studies have shown that wetlands responded to climate change on glacial to interglacial timescales, but their sensitivity to short-lived climate perturbations is largely unknown. Here, we show that GWD deposits in the Las Vegas Valley (southern Nevada, United States) provide a detailed and nearly complete record of dynamic hydrologic changes during the past 35 ka (thousands of calibrated (14)C years before present), including cycles of wetland expansion and contraction that correlate tightly with climatic oscillations recorded in the Greenland ice cores. Cessation of discharge associated with rapid warming events resulted in the collapse of entire wetland systems in the Las Vegas Valley at multiple times during the late Quaternary. On average, drought-like conditions, as recorded by widespread erosion and the formation of desert soils, lasted for a few centuries. This record illustrates the vulnerability of desert wetland flora and fauna to abrupt climate change. It also shows that GWD deposits can be used to reconstruct paleohydrologic conditions at millennial to submillennial timescales and informs conservation efforts aimed at protecting these fragile ecosystems in the face of anthropogenic warming.

  7. From Abrupt Change to the Future (Hans Oeschger Medal Lecture)

    NASA Astrophysics Data System (ADS)

    Stocker, T.

    2009-04-01

    The award of the Oeschger Medal 2009 is a particular honor and pleasure for me as I was given the chance to take over from Hans Oeschger the lead of a wonderful Institute at the University of Bern in 1993. Very apprehensive first, in front of the huge expectations and challenges, I quickly found dear colleagues, close collaborators and extremely supportive staff who all dedicated their time and creativity to work for the common goal of better understanding the Earth System, its variations in the past and its sensitivity to perturbations that man is inflicting on it today. Although met with innate skepticism first by the experimental physicists, our efforts in modelling, particularly the approach of using climate models of reduced complexity, quickly paid off and provided added value to the hard won data and measurements from polar ice cores. It is clear that modelling in such a diverse environment is so much more stimulating and enriching than working on a sophisticated parameterisation in a big modelling centre. Simple models have suggested that the Earth System may have limited stability and that rather fundamental changes could be triggered by the increase of greenhouse gases. However, it is the unique results from polar ice cores, particularly from Greenland that showed that, indeed, the Earth System has limited stability and can react in extremely abrupt ways to changes in forcing. Likewise, the Antarctic ice cores have provided one of the corner stones of our knowledge about climate change: Concentrations of CO2 are today 29% higher than ever during the last 800,000 years. These two fundamental insights from the paleoclimatic archive call for accelerated research into the sensitivity of the climate system and its components to perturbations, as well as the investigation of feedback mechanisms in the biogeochemical cycles that are disturbed by the input of CO2 into the atmosphere by burning fossil fuels and land use change. Our research has only scratched the

  8. Wildfire responses to abrupt climate change in North America.

    PubMed

    Marlon, J R; Bartlein, P J; Walsh, M K; Harrison, S P; Brown, K J; Edwards, M E; Higuera, P E; Power, M J; Anderson, R S; Briles, C; Brunelle, A; Carcaillet, C; Daniels, M; Hu, F S; Lavoie, M; Long, C; Minckley, T; Richard, P J H; Scott, A C; Shafer, D S; Tinner, W; Umbanhowar, C E; Whitlock, C

    2009-02-24

    It is widely accepted, based on data from the last few decades and on model simulations, that anthropogenic climate change will cause increased fire activity. However, less attention has been paid to the relationship between abrupt climate changes and heightened fire activity in the paleorecord. We use 35 charcoal and pollen records to assess how fire regimes in North America changed during the last glacial-interglacial transition (15 to 10 ka), a time of large and rapid climate changes. We also test the hypothesis that a comet impact initiated continental-scale wildfires at 12.9 ka; the data do not support this idea, nor are continent-wide fires indicated at any time during deglaciation. There are, however, clear links between large climate changes and fire activity. Biomass burning gradually increased from the glacial period to the beginning of the Younger Dryas. Although there are changes in biomass burning during the Younger Dryas, there is no systematic trend. There is a further increase in biomass burning after the Younger Dryas. Intervals of rapid climate change at 13.9, 13.2, and 11.7 ka are marked by large increases in fire activity. The timing of changes in fire is not coincident with changes in human population density or the timing of the extinction of the megafauna. Although these factors could have contributed to fire-regime changes at individual sites or at specific times, the charcoal data indicate an important role for climate, and particularly rapid climate change, in determining broad-scale levels of fire activity.

  9. Abrupt changes in North American climate during early Holocene times

    NASA Astrophysics Data System (ADS)

    Hu, F. S.; Slawinski, D.; Wright, H. E.; Ito, E.; Johnson, R. G.; Kelts, K. R.; McEwan, R. F.; Boedigheimer, A.

    1999-07-01

    Recent studies of the Greenland ice cores have offered many insights into Holocene climatic dynamics at decadal to century timescales. Despite the abundance of continental records of Holocene climate, few have sufficient chronological control and sampling resolution to compare with the Greenland findings. Butannually laminated sediments (varves) from lakes can provide high-resolution continental palaeoclimate data with secure chronologies. Here we present analyses of varved sediments from Deep Lake in Minnesota, USA. Trends in the stable oxygen-isotope composition of the sedimentary carbonate indicate a pronounced climate cooling from 8.9 to 8.3kyr before present, probably characterized by increased outbreaks of polar air, decreased precipitation temperatures, and a higher fraction of the annual precipitation falling as snow. The abrupt onset of this climate reversal, over several decades, was probably caused by a reorganization of atmospheric circulation and cooling of the Arctic airmass in summer that resulted from the final collapse of the Laurentide ice near Hudson Bay and the discharge of icebergs from the Quebec and Keewatin centres into the Tyrell Sea. The timing and duration of this climate reversal suggest that it is distinct from the prominent widespread cold snap that occurred 8,200 years ago in Greenland and other regions,,. No shifts in the oxygen-isotope composition of sediment carbonate occurred at 8.2kyr before present at Deep Lake, but varve thickness increased dramatically, probably as a result of increased deposition of aeolian dust. Taken together, our data suggest that two separate regional-scale climate reversals occurred between 9,000 and 8,000 years ago, and that they were driven by different mechanisms.

  10. Maternal Sleep Duration and Complaints of Vital Exhaustion during Pregnancy is Associated with Placental Abruption

    PubMed Central

    Qiu, Chunfang; Sanchez, Sixto E.; Gelaye, Bizu; Enquobahrie, Daniel A.; Ananth, Cande V.; Williams, Michelle A.

    2014-01-01

    OBJECTIVE Sleep disorders are associated with cardiovascular complications and preterm delivery (PTD). Insufficient sleep results in metabolic alterations and increased inflammation, both known to contribute to placental abruption (abruption), a determinant of PTD. We examined associations of abruption with sleep duration and complaints of vital exhaustion. METHODS The study included 164 abruption cases and 160 controls in a multicenter study in Peru. Data on habitual sleep duration and vital exhaustion during the first 6 months of pregnancy were elicited during interviews conducted following delivery. Women were categorized according to short, normal and long sleep duration (≤6, 7-8 and ≥9 h); and frequency of feeling exhausted. Odds ratios (OR) and 95% confidence intervals (CI) were calculated. RESULTS Short and long sleep durations were associated with increased odds of abruption. The ORs of abruption in relation to short (≤6 h) and long (≥9 h) sleep duration were 2.0 (95%CI 1.1-3.7) and 2.1 (95%CI 1.1-4.1), compared with normal sleep duration (7-8 h). Complaints of vital exhaustion were also associated with abruption (OR=2.37; 95%CI 1.46-3.85), and were independent of sleep duration. CONCLUSION We extend the existing literature and support the thesis that maternal sleep habits and disorders should be assessed among pregnant women. PMID:24749793

  11. Detecting abrupt dynamic change based on changes in the fractal properties of spatial images

    NASA Astrophysics Data System (ADS)

    Liu, Qunqun; He, Wenping; Gu, Bin; Jiang, Yundi

    2016-08-01

    Many abrupt climate change events often cannot be detected timely by conventional abrupt detection methods until a few years after these events have occurred. The reason for this lag in detection is that abundant and long-term observational data are required for accurate abrupt change detection by these methods, especially for the detection of a regime shift. So, these methods cannot help us understand and forecast the evolution of the climate system in a timely manner. Obviously, spatial images, generated by a coupled spatiotemporal dynamical model, contain more information about a dynamic system than a single time series, and we find that spatial images show the fractal properties. The fractal properties of spatial images can be quantitatively characterized by the Hurst exponent, which can be estimated by two-dimensional detrended fluctuation analysis (TD-DFA). Based on this, TD-DFA is used to detect an abrupt dynamic change of a coupled spatiotemporal model. The results show that the TD-DFA method can effectively detect abrupt parameter changes in the coupled model by monitoring the changing in the fractal properties of spatial images. The present method provides a new way for abrupt dynamic change detection, which can achieve timely and efficient abrupt change detection results.

  12. Gradual and abrupt changes during the Mid-Pleistocene Transition

    NASA Astrophysics Data System (ADS)

    Ford, Heather L.; Sosdian, Sindia M.; Rosenthal, Yair; Raymo, Maureen E.

    2016-09-01

    During the Mid-Pleistocene Transition (MPT), the dominant glacial-interglacial cyclicity as inferred from the marine δ18O records of benthic foraminifera (δ18Obenthic) changed from 41 kyr to 100 kyr years in the absence of a comparable change in orbital forcing. Currently, only two Mg/Ca-derived, high-resolution bottom water temperature (BWT) records exist that can be used with δ18Obenthic records to separate temperature and ice volume signals over the Pleistocene. However, these two BWT records suggest a different pattern of climate change occurred over the MPT-a record from North Atlantic DSDP Site 607 suggests BWT decreased with no long-term trend in ice volume over the MPT, while South Pacific ODP Site 1123 suggests that BWT has been relatively stable over the last 1.5 Myr but that there was an abrupt increase in ice volume at ∼900 kyr. In this paper we attempt to reconcile these two views of climate change across the MPT. Specifically, we investigated the suggestion that the secular BWT trend obtained from Mg/Ca measurements on Cibicidoides wuellerstorfi and Oridorsalis umbonatus species from N. Atlantic Site 607 is biased by the possible influence of Δ[CO32-] on Mg/Ca values in these species by generating a low-resolution BWT record using Uvigerina spp., a genus whose Mg/Ca values are not thought to be influenced by Δ[CO32-]. We find a long-term BWT cooling of ∼2-3°C occurred from 1500 to ∼500 kyr in the N. Atlantic, consistent with the previously generated C. wuellerstorfi and O. umbonatus BWT record. We also find that changes in ocean circulation likely influenced δ18Obenthic, BWT, and δ18Oseawater records across the MPT. N. Atlantic BWT cooling starting at ∼1.2 Ma, presumably driven by high-latitude cooling, may have been a necessary precursor to a threshold response in climate-ice sheet behavior at ∼900 ka. At that point, a modest increase in ice volume and thermohaline reorganization may have caused enhanced sensitivity to the 100 kyr

  13. Arctic Ocean freshwater as a trigger for abrupt climate change

    NASA Astrophysics Data System (ADS)

    Bradley, Raymond; Condron, Alan; Coletti, Anthony

    2016-04-01

    The cause of the Younger Dryas cooling remains unresolved despite decades of debate. Current arguments focus on either freshwater from Glacial Lake Agassiz drainage through the St Lawrence or the MacKenzie river systems. High resolution ocean modeling suggests that freshwater delivered to the North Atlantic from the Arctic Ocean through Fram Strait would have had more of an impact on Atlantic Meridional Overturning Circulation (AMOC) than freshwater from the St Lawrence. This has been interpreted as an argument for a MacKenzie River /Lake Agassiz freshwater source. However, it is important to note that although the modeling identifies Fram Strait as the optimum location for delivery of freshwater to disrupt the AMOC, this does not mean the freshwater source came from Lake Agassiz. Another potential source of freshwater is the Arctic Ocean ice cover itself. During the LGM, ice cover was extremely thick - many tens of meters in the Canada Basin (at least), resulting in a hiatus in sediment deposition there. Extreme ice thickness was related to a stagnant circulation, very low temperatures and continuous accumulation of snow on top of a base of sea-ice. This resulted in a large accumulation of freshwater in the Arctic Basin. As sea-level rose and a more modern circulation regime became established in the Arctic, this freshwater was released from the Arctic Ocean through Fram Strait, leading to extensive sea-ice formation in the North Atlantic (Greenland Sea) and a major reduction in the AMOC. Here we present new model results and a review of the paleoceanographic evidence to support this hypothesis. The bottom line is that the Arctic Ocean was likely a major player in causing abrupt climate change in the past, via its influence on the AMOC. Although we focus here on the Younger Dryas, the Arctic Ocean has been repeatedly isolated from the world ocean during glacial periods of the past. When these periods of isolation ended, it is probable that there were significant

  14. Response of dominant wind wave fields to abrupt wind increase

    NASA Astrophysics Data System (ADS)

    Caulliez, Guillemette

    2013-04-01

    Over the last decades, significant progress has been made in modelling wave field development by wind observed at sea, based on more elaborated numerical schemes and refined parametrizations of wind energy input and wave dissipation. In such models, the wind wave growth in space or time is generally governed by the average wind speed evaluated at one reference level and the natural wind speed variability is neglected. However, the impact of this assumption is not really known, mainly because of the lack of appropriate observations. To revisit this question, we report a detailed laboratory investigation aimed at describing the dominant wave field evolution resulting from an abrupt local wind speed increase. The experiments were conducted in the large Marseille-Luminy wind wave tank for moderate to high wind conditions. At 23 m fetch, a contraction of the wind tunnel section by a convergent profile created a spatial wind speed acceleration over a distance of about 2 m. Downwind, the wind speed, enhanced by a factor 1.4, was kept constant up to the end of the water tank. The wind wave field development induced by such a "wind gust" was investigated at successive fetches by wave probes and compared to those observed at similar fetches for homogeneous wind conditions. When wind increases, these observations first revealed no dramatic change in the evolution of the dominant spectral peak with fetch. The dominant wave energy which increases slowly for constant wind conditions, follows the wind speed but with a significant space lag. For well-established gravity wave fields, the space relaxation scales which describe this evolution do not depend noticeably on wind, all the curves collapse into a single one when wave quantities are normalized by their value observed just upstream the convergent profile. The wave growth rate observed for the new equilibrium state can be described by the Hasselman et al. (1973) relationship but with an "equivalent'' shorter fetch since, in

  15. The New Orleans Forensic Aftercare Clinic: a seven year review of hospital discharged and jail diverted clients.

    PubMed

    Bertman-Pate, Lisa Jo; Burnett, Darla M R; Thompson, John W; Calhoun, Clay J; Deland, Sarah; Fryou, R Mark

    2004-01-01

    This paper provides a review of the Forensic Aftercare Clinic Conditional Release Program (FAC), which has been operating since December, 1995, in New Orleans, LA. The FAC is a community based program that provides clinical, rehabilitative, and supervisory services to individuals who have been found not guilty by reason of insanity or unrestorably incompetent to proceed and who have been discharged from inpatient settings or diverted from jail settings and placed on conditional release by district court orders. 119 clients participated in FAC over a 7 year period. Forty-one (34.4%) had their conditional release revoked. Of the total population, 12 (10.1%) were re-arrested on at least one charge, 3 (2.4%) were arrested on felony charges, and 9 (7.6%) on misdemeanors. Only two of these charges were violent, resulting in no significant harm to victims. Twenty (16.8%) were hospitalized at least once due to relapse. Clients diverted from jail to community settings did not differ significantly on most variables from clients who were discharged from long-term hospitalization. Data related to public safety and client diversion demonstrate that clients, when appropriate, can be safely diverted to the community in lieu of hospitalization. The number of statewide clients who have been discharged from the forensic hospital into the community has increased steadily from 13 in 1995 to 29 in 2002, and statewide diversion clients have steadily increased from 0 in 1992 to 20 in 2002. The increase in statewide diversion clients and forensic discharges over this 7 year period indicates that stakeholders see the viability of the program as an alternative to as well as a step-down from long-term forensic hospitalization.

  16. Modeling and optimizing the design of matrix treatments in carbonate reservoirs with self-diverting acid systems

    NASA Astrophysics Data System (ADS)

    Bulgakova, G. T.; Kharisov, R. Ya; Sharifullin, A. R.; Pestrikov, A. V.

    2015-01-01

    Application of a self-diverting-acid based on viscoelastic surfactant (SDVA) is a promising technology for improving the efficacy of acid treatment in oil and gas-bearing carbonate reservoirs. In this study, we present a mathematical model for assessing SDVA flow and reaction with carbonate rock using the SDVA rheological characteristics. The model calculates the technological parameters for acidizing operations and the prediction of well productivity after acid treatment, in addition to technical and economic optimization of the acidizing process by modeling different acid treatment options with varying volumes, injection rates, process fluids stages and initial economic scenarios.

  17. Abrupt vegetation transitions characterise long-term Amazonian peatland development

    NASA Astrophysics Data System (ADS)

    Roucoux, K. H.; Baker, T. R.; Gosling, W. D.; Honorio Coronado, E.; Jones, T. D.; Lahteenoja, O.; Lawson, I. T.

    2012-04-01

    woodland with abundant Myrtaceae; (4) Expansion of Mauritia/Mauritiella palm swamp vegetation c. 1000 years ago representing establishment of the present day vegetation community. Our results show that the vegetation at this site has undergone continuous change throughout the period of peat formation. The sequence of vegetation development is not straightforward, being characterised by abrupt transitions between vegetation types and reversals in the apparent trajectory of change. Overall this suggests that the system is highly dynamic on centennial to millennial timescales. This complexity may reflect vegetation responses to a combination of external (physical) and internal (biological) drivers and the presence of thresholds in the system. Future investigations will work towards understanding the processes that drive these vegetation transitions and predicting peatland vegetation responses to future climatic change.

  18. Virtual stenting workflow with vessel-specific initialization and adaptive expansion for neurovascular stents and flow diverters.

    PubMed

    Paliwal, Nikhil; Yu, Hongyu; Xu, Jinhui; Xiang, Jianping; Siddiqui, Adnan H; Yang, Xinjian; Li, Haiyun; Meng, Hui

    2016-10-01

    Endovascular intervention using traditional neurovascular stents and densely braided flow diverters (FDs) have become the preferred treatment strategies for traditionally challenging intracranial aneurysms. Modeling stent and FD deployment in patient-specific aneurysms and its flow modification results prior to the actual intervention can potentially predict the patient outcome and treatment optimization. We present a clinically focused, streamlined virtual stenting workflow that efficiently simulates stent and FD treatment in patient-specific aneurysms based on expanding a simplex mesh structure. The simplex mesh is generated using an innovative vessel-specific initialization technique, which uses the patient's parent artery diameter to identify the initial position of the simplex mesh inside the artery. A novel adaptive expansion algorithm enables the acceleration of deployment process by adjusting the expansion forces based on the distance of the simplex mesh from the parent vessel. The virtual stenting workflow was tested by modeling the treatment of two patient-specific aneurysms using the Enterprise stent and the Pipeline Embolization Device (commercial FD). Both devices were deployed in the aneurysm models in a few seconds. Computational fluid dynamics analyses of pre- and post-treatment aneurysmal hemodynamics show flow reduction in the aneurysmal sac in treated aneurysms, with the FD diverting more flow than the Enterprise stent. The test results show that this workflow can rapidly simulate clinical deployment of stents and FDs, hence paving the way for its future clinical implementation.

  19. Angiographic analysis for phantom simulations of endovascular aneurysm treatments with a new fully retrievable asymmetric flow diverter

    NASA Astrophysics Data System (ADS)

    Yoganand, Aradhana; Wood, Rachel P.; Jimenez, Carlos; Siddiqui, Adnan; Snyder, Kenneth; Setlur Nagesh, S. V.; Bednarek, D. R.; Rudin, S.; Baier, Robert; Ionita, Ciprian N.

    2015-03-01

    Digital Subtraction Angiography (DSA) is the main diagnostic tool for intracranial aneurysms (IA) flow-diverter (FD) assisted treatment. Based on qualitative contrast flow evaluation, interventionists decide on subsequent steps. We developed a novel fully Retrievable Asymmetric Flow-Diverter (RAFD) which allows controlled deployment, repositioning and detachment achieve optimal flow diversion. The device has a small low porosity or solid region which is placed such that it would achieve maximum aneurysmal in-jet flow deflection with minimum impairment to adjacent vessels. We tested the new RAFD using a flow-loop with an idealized and a patient specific IA phantom in carotid-relevant physiological conditions. We positioned the deflection region at three locations: distally, center and proximally to the aneurysm orifice and analyzed aneurysm dome flow using DSA derived maps for mean transit time (MTT) and bolus arrival times (BAT). Comparison between treated and untreated (control) maps quantified the RAFD positioning effect. Average MTT, related to contrast presence in the aneurysm dome increased, indicating flow decoupling between the aneurysm and parent artery. Maximum effect was observed in the center and proximal position (~75%) of aneurysm models depending on their geometry. BAT maps, correlated well with inflow jet direction and magnitude. Reduction and jet dispersion as high as about 50% was observed for various treatments. We demonstrated the use of DSA data to guide the placement of the RAFD and showed that optimum flow diversion within the aneurysm dome is feasible. This could lead to more effective and a safer IA treatment using FDs.

  20. Virtual Stenting Workflow with Vessel-Specific Initialization and Adaptive Expansion for Neurovascular Stents and Flow Diverters

    PubMed Central

    Xu, Jinhui; Xiang, Jianping; Siddiqui, Adnan; Yang, Xinjian; Li, Haiyun; Meng, Hui

    2016-01-01

    Endovascular intervention using traditional neurovascular stents and densely braided flow diverters (FDs) have become the preferred treatment strategies for traditionally challenging intracranial aneurysms (IAs). Modeling stent and FD deployment in patient-specific aneurysms and its flow modification results prior to the actual intervention can potentially predict the patient outcome and treatment optimization. We present a clinically focused, streamlined virtual stenting workflow that efficiently simulates stent and FD treatment in patient-specific aneurysms based on expanding a simplex mesh structure. The simplex mesh is generated using an innovative vessel-specific initialization technique, which uses the patient’s parent artery diameter to identify the initial position of the simplex mesh inside the artery. A novel adaptive expansion algorithm enables the acceleration of deployment process by adjusting the expansion forces based on the distance of the simplex mesh from the parent vessel. The virtual stenting workflow was tested by modeling the treatment of two patient-specific aneurysms using the Enterprise stent and the Pipeline Embolization Device (commercial FD). Both devices were deployed in the aneurysm models in a few seconds. Computational fluid dynamics analyses of pre- and post-treatment aneurysmal hemodynamics show flow reduction in the aneurysmal sac in treated aneurysms, with the FD diverting more flow than the Enterprise stent. The test results show that this workflow can rapidly simulate clinical deployment of stents and FDs, hence paving the way for its future clinical implementation. PMID:26899135

  1. The applicability of research on moving cut data-approximate entropy on abrupt climate change detection

    NASA Astrophysics Data System (ADS)

    Jin, Hongmei; He, Wenping; Liu, Qunqun; Wang, Jinsong; Feng, Guolin

    2016-04-01

    In this study, the performance of moving cut data-approximate entropy (MC-ApEn) to detect abrupt dynamic changes was investigated. Numerical tests in a time series model indicate that the MC-ApEn method is suitable for the detection of abrupt dynamic changes for three types of meteorological data: daily maximum temperature, daily minimum temperature, and daily precipitation. Additionally, the MC-ApEn method was used to detect abrupt climate changes in daily precipitation data from Northwest China and the Pacific Decadal Oscillation (PDO) index. The results show an abrupt dynamic change in precipitation in 1980 and in the PDO index in 1976. The times indicated for the abrupt changes are identical to those from previous results. Application of the analysis to observational data further confirmed the performance of the MC-ApEn method. Moreover, MC-ApEn outperformed the moving t test (MTT) and the moving detrended fluctuation analysis (MDFA) methods for the detection of abrupt dynamic changes in a simulated 1000-point daily precipitation dataset.

  2. Endovascular Treatment of Intracranial Aneurysms in the Flow Diverter Era: Frequency of Use and Results in a Consecutive Series of 550 Treatments in a Single Centre

    PubMed Central

    Jan van Rooij, Willem; Bechan, Ratna S; Peluso, Jo P; Sluzewski, Menno

    2014-01-01

    Summary Flow diverter devices became available in our department in 2009. We considered treatment with flow diverters only in patients with aneurysms not suitable for surgery or conventional endovascular techniques. This paper presents our preliminary experience with flow diverters in a consecutive series of 550 endovascular aneurysm treatments. Between January 2009 and July 2013, 550 endovascular treatments for intracranial aneurysms were performed. Of these, 490 were first-time aneurysm treatments in 464 patients and 61 were additional treatments of previously coiled aneurysms in 51 patients. Endovascular treatments consisted of selective coiling in 445 (80.8%), stent-assisted coiling in 68 (12.4%), balloon-assisted coiling in 13 (2.4%), parent vessel occlusion in 12 (2.2%) and flow diverter treatment in 12 (2.2%). Eleven patients with 12 aneurysms were treated with flow diverters. Two patients had ruptured dissecting aneurysms. One patient with a basilar trunk aneurysm died of acute in stent thrombosis and another patient died of brain stem ischaemia at 32 months follow-up. One patient had ischaemia with permanent neurological deficit. Two aneurysms are still open at up to 30 months follow-up. Flow diversion was used in 2% of all endovascular treatments. Both our own poor results and the high complication rates reported in the literature have converted our initial enthusiasm to apprehension and hesitancy. The safety and efficacy profile of flow diversion should discourage the use of these devices in aneurysms that can be treated with other techniques. PMID:25207905

  3. From free expansion to abrupt compression of an ideal gas

    NASA Astrophysics Data System (ADS)

    Anacleto, Joaquim; Pereira, Mário G.

    2009-01-01

    Using macroscopic thermodynamics, the general law for adiabatic processes carried out by an ideal gas was studied. It was shown that the process reversibility is characterized by the adiabatic reversibility coefficient r, in the range 0 <= r <= 1 for expansions and r >= 1 for compressions. The particular cases of free expansion and reversible adiabatic processes correspond to r = 0 and r = 1, respectively. To conclude the interpretation of r, the relation between r and the variation of the system entropy was also obtained. Comparison between this study and one restricted to expansions following a microscopic point of view showed not only equivalent interpretations but also that our approach is more general, since it also comprises compressions, provides an objective relation between r and entropy change and considers instantaneous varying values of the adiabatic reversibility coefficient. Finally, simulations of selected adiabatic processes are performed and numerical calculations of r are presented. This paper is intended primarily for the undergraduate student, although a comparison with the aforementioned work also requires a background in thermodynamics and kinetic theory.

  4. Oxidative stress diverts tRNA synthetase to nucleus for protection against DNA damage.

    PubMed

    Wei, Na; Shi, Yi; Truong, Lan N; Fisch, Kathleen M; Xu, Tao; Gardiner, Elisabeth; Fu, Guangsen; Hsu, Yun-Shiuan Olivia; Kishi, Shuji; Su, Andrew I; Wu, Xiaohua; Yang, Xiang-Lei

    2014-10-23

    Tyrosyl-tRNA synthetase (TyrRS) is known for its essential aminoacylation function in protein synthesis. Here we report a function for TyrRS in DNA damage protection. We found that oxidative stress, which often downregulates protein synthesis, induces TyrRS to rapidly translocate from the cytosol to the nucleus. We also found that angiogenin mediates or potentiates this stress-induced translocalization. The nuclear-localized TyrRS activates transcription factor E2F1 to upregulate the expression of DNA damage repair genes such as BRCA1 and RAD51. The activation is achieved through direct interaction of TyrRS with TRIM28 to sequester this vertebrate-specific epigenetic repressor and its associated HDAC1 from deacetylating and suppressing E2F1. Remarkably, overexpression of TyrRS strongly protects against UV-induced DNA double-strand breaks in zebrafish, whereas restricting TyrRS nuclear entry completely abolishes the protection. Therefore, oxidative stress triggers an essential cytoplasmic enzyme used for protein synthesis to translocate to the nucleus to protect against DNA damage.

  5. Diverting victims of commercial sexual exploitation from juvenile detention: development of the InterCSECt screening protocol.

    PubMed

    Salisbury, Emily J; Dabney, Jonathan D; Russell, Kelli

    2015-04-01

    Identifying victims of commercial sexual exploitation in the juvenile justice system is a challenging complexity requiring concerted organizational commitment. Using a three-tiered, trauma-informed screening process, a 3½-month pilot intervention was implemented in Clark County Juvenile Court (Washington) to identify victims in an effort to connect them to community youth advocates and sexual assault resources. A total of 535 boys and girls ages 9 to 19 were screened during intake; 47 of these youth reported risk factors associated with commercial sexual exploitation of children (CSEC) and were subsequently referred to community advocates. Six youth (all girls) were confirmed CSEC victims and were successfully diverted from juvenile detention. Study results suggest that despite the lack of reliable data surrounding the prevalence of CSEC, juvenile justice agencies need to become educated on the risk factors to triage victims to services.

  6. Structure-activity relationships of IKM-159: Diverted synthesis and biological evaluation of a series of C5-oxy analogs.

    PubMed

    Chiba, Manami; Fujimoto, Chikako; Sakai, Ryuichi; Oikawa, Masato

    2015-05-01

    Ligands for neuronal receptors are important for understanding the biological functions as well as for treatment of neuronal diseases associated with. Here, we report diverted synthesis and biological evaluation of four C-ring analogs of IKM-159, a subtype-selective inhibitor for (S)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid (AMPA)-type ionotropic glutamate receptor. Starting from iodinated 7-oxanorbornene 7, those analogs 3-6 were successfully synthesized in 7.0-33% yields over 8-11 steps via a common intermediate 13. Intracerebroventricular injection of those analogs on mice showed that introduction of oxo group on the C-ring (analogs 4, 5) or cleavage of the C-ring (analog 6) caused significant loss of the activity, while the ether analog 3 still retain the suppressed motor activity, indicating the importance of the C-ring in the neuronal activity of IKM-159.

  7. Catalogue of abrupt shifts in Intergovernmental Panel on Climate Change climate models.

    PubMed

    Drijfhout, Sybren; Bathiany, Sebastian; Beaulieu, Claudie; Brovkin, Victor; Claussen, Martin; Huntingford, Chris; Scheffer, Marten; Sgubin, Giovanni; Swingedouw, Didier

    2015-10-27

    Abrupt transitions of regional climate in response to the gradual rise in atmospheric greenhouse gas concentrations are notoriously difficult to foresee. However, such events could be particularly challenging in view of the capacity required for society and ecosystems to adapt to them. We present, to our knowledge, the first systematic screening of the massive climate model ensemble informing the recent Intergovernmental Panel on Climate Change report, and reveal evidence of 37 forced regional abrupt changes in the ocean, sea ice, snow cover, permafrost, and terrestrial biosphere that arise after a certain global temperature increase. Eighteen out of 37 events occur for global warming levels of less than 2°, a threshold sometimes presented as a safe limit. Although most models predict one or more such events, any specific occurrence typically appears in only a few models. We find no compelling evidence for a general relation between the overall number of abrupt shifts and the level of global warming. However, we do note that abrupt changes in ocean circulation occur more often for moderate warming (less than 2°), whereas over land they occur more often for warming larger than 2°. Using a basic proportion test, however, we find that the number of abrupt shifts identified in Representative Concentration Pathway (RCP) 8.5 scenarios is significantly larger than in other scenarios of lower radiative forcing. This suggests the potential for a gradual trend of destabilization of the climate with respect to such shifts, due to increasing global mean temperature change. PMID:26460042

  8. Catalogue of abrupt shifts in Intergovernmental Panel on Climate Change climate models

    PubMed Central

    Drijfhout, Sybren; Bathiany, Sebastian; Beaulieu, Claudie; Brovkin, Victor; Claussen, Martin; Huntingford, Chris; Scheffer, Marten; Sgubin, Giovanni; Swingedouw, Didier

    2015-01-01

    Abrupt transitions of regional climate in response to the gradual rise in atmospheric greenhouse gas concentrations are notoriously difficult to foresee. However, such events could be particularly challenging in view of the capacity required for society and ecosystems to adapt to them. We present, to our knowledge, the first systematic screening of the massive climate model ensemble informing the recent Intergovernmental Panel on Climate Change report, and reveal evidence of 37 forced regional abrupt changes in the ocean, sea ice, snow cover, permafrost, and terrestrial biosphere that arise after a certain global temperature increase. Eighteen out of 37 events occur for global warming levels of less than 2°, a threshold sometimes presented as a safe limit. Although most models predict one or more such events, any specific occurrence typically appears in only a few models. We find no compelling evidence for a general relation between the overall number of abrupt shifts and the level of global warming. However, we do note that abrupt changes in ocean circulation occur more often for moderate warming (less than 2°), whereas over land they occur more often for warming larger than 2°. Using a basic proportion test, however, we find that the number of abrupt shifts identified in Representative Concentration Pathway (RCP) 8.5 scenarios is significantly larger than in other scenarios of lower radiative forcing. This suggests the potential for a gradual trend of destabilization of the climate with respect to such shifts, due to increasing global mean temperature change. PMID:26460042

  9. Catalogue of abrupt shifts in Intergovernmental Panel on Climate Change climate models.

    PubMed

    Drijfhout, Sybren; Bathiany, Sebastian; Beaulieu, Claudie; Brovkin, Victor; Claussen, Martin; Huntingford, Chris; Scheffer, Marten; Sgubin, Giovanni; Swingedouw, Didier

    2015-10-27

    Abrupt transitions of regional climate in response to the gradual rise in atmospheric greenhouse gas concentrations are notoriously difficult to foresee. However, such events could be particularly challenging in view of the capacity required for society and ecosystems to adapt to them. We present, to our knowledge, the first systematic screening of the massive climate model ensemble informing the recent Intergovernmental Panel on Climate Change report, and reveal evidence of 37 forced regional abrupt changes in the ocean, sea ice, snow cover, permafrost, and terrestrial biosphere that arise after a certain global temperature increase. Eighteen out of 37 events occur for global warming levels of less than 2°, a threshold sometimes presented as a safe limit. Although most models predict one or more such events, any specific occurrence typically appears in only a few models. We find no compelling evidence for a general relation between the overall number of abrupt shifts and the level of global warming. However, we do note that abrupt changes in ocean circulation occur more often for moderate warming (less than 2°), whereas over land they occur more often for warming larger than 2°. Using a basic proportion test, however, we find that the number of abrupt shifts identified in Representative Concentration Pathway (RCP) 8.5 scenarios is significantly larger than in other scenarios of lower radiative forcing. This suggests the potential for a gradual trend of destabilization of the climate with respect to such shifts, due to increasing global mean temperature change.

  10. On the effects of the equilibrium model in gyrokinetic simulations: from s-α to diverted MHD equilibrium

    NASA Astrophysics Data System (ADS)

    Burckel, A.; Sauter, O.; Angioni, C.; Candy, J.; Fable, E.; Lapillonne, X.

    2010-11-01

    In order to better identify the role of the magnetic topology on ITG and TEM instabilities, different MHD equilibria with increasing complexity are calculated using the CHEASE code [1]. We start from the geometry of the s-α cyclone benchmark case [2], consider the corresponding circular numerical equilibrium, and then successively add a non zero value of a consistent with the kinetic profiles, an elongation of 1.68, a triangularity of 0.15, and finally an up-down asymmetry corresponding to a single-null diverted geometry. This gives the opportunity to study separately the effect of each main characteristics of the equilibrium on microinstabilities in core plasmas. Linear local electrostatic gyrokinetic simulations of these different numerical equilibria and of their corresponding analytical descriptions (Miller-type representations [3]) are performed using the codes GS2 [4, 5] and GYRO[6]. It is observed that each modification of the equilibrium has an influence on the results of gyrokinetic simulations. The effect of the α parameter can compensate the stabilizing effect of an increase in the elongation. A comparison between the up-down symmetric shaped equilibrium and its corresponding diverted configuration show a non negligible effect on the growth rate of ITG and TEM turbulence. The comparison between the local Miller model and using a full equilibrium shows that it is mainly the indirect change of elongation in the plasma core which influences the results. The global aim is to provide well defined benchmark cases including real geometry and kinetic electrons physics, since this is not analyzed by the cyclone case. In addition, the goal is to define a procedure for testing of local simulations inspired by experimental constraints and results.

  11. Sputtering of the Europa surface by thermal ions from the torus and pickup ions in a diverted flow

    NASA Astrophysics Data System (ADS)

    Dols, Vincent J.; Cassidy, Timothy A.; Bagenal, Fran; Crary, Frank; Delamere, Peter A.

    2016-10-01

    Europa's atmosphere is very tenuous and is mainly composed of O2. It is thought to be produced by ion bombardment of its icy surface. Several ion populations may contribute to this sputtering:1) The thermal plasma of the torus (~ 1keV including ram velocity), which may be partially diverted around the moon by the ionospheric currents2) The energetic sulfur and hydrogen ions (~10 keV-MeV), which diffuse inward toward Europa's orbit3) and possibly the newly ionized O2 molecules that are picked up by the torus flow and hit the surface.The relative contribution of each sputtering ion population has been debated for more than three decades with estimated O2 sputtering rates varying by ~2 order of magnitude. Modelers have historically focused on a single piece of the puzzle: plasma modelers assume a static atmosphere and tend not to check that their sources and losses are consistent with their prescribed atmosphere; while atmospheric modelers neglect the electro-dynamic interaction that diverts torus plasma around the moon, and limits the ion flux to the surface.In this work, we present a first step to compute self-consistently the atmospheric production by the bombardment of the thermal plasma and pickup O2+ ions.1) We calculate the plasma flow around Europa with a MHD model2) We use this flow in a multi-species physical chemistry model of the plasma-atmosphere interaction to compute the ion fluxes into Europa's surface.3) We compute the production rate of O2 resulting from the ice sputtering by thermal and pickup ions and compare the resulting atmospheric source rate to previously published results.

  12. Angiographic analysis for phantom simulations of endovascular aneurysm treatments with a new fully retrievable asymmetric flow diverter

    PubMed Central

    Yoganand, Aradhana; Wood, Rachel P.; Jimenez, Carlos; Siddiqui, Adnan; Snyder, Kenneth; Nagesh, S.V. Setlur; Bednarek, D.R.; Rudin, S; Baier, Robert; Ionita, Ciprian N

    2015-01-01

    Digital Subtraction Angiography (DSA) is the main diagnostic tool for intracranial aneurysms (IA) flow-diverter (FD) assisted treatment. Based on qualitative contrast flow evaluation, interventionists decide on subsequent steps. We developed a novel fully Retrievable Asymmetric Flow-Diverter (RAFD) which allows controlled deployment, repositioning and detachment achieve optimal flow diversion. The device has a small low porosity or solid region which is placed such that it would achieve maximum aneurysmal in-jet flow deflection with minimum impairment to adjacent vessels. We tested the new RAFD using a flow-loop with an idealized and a patient specific IA phantom in carotid-relevant physiological conditions. We positioned the deflection region at three locations: distally, center and proximally to the aneurysm orifice and analyzed aneurysm dome flow using DSA derived maps for mean transit time (MTT) and bolus arrival times (BAT). Comparison between treated and untreated (control) maps quantified the RAFD positioning effect. Average MTT, related to contrast presence in the aneurysm dome increased, indicating flow decoupling between the aneurysm and parent artery. Maximum effect was observed in the center and proximal position (~75%) of aneurysm models depending on their geometry. BAT maps, correlated well with inflow jet direction and magnitude. Reduction and jet dispersion as high as about 50% was observed for various treatments. We demonstrated the use of DSA data to guide the placement of the RAFD and showed that optimum flow diversion within the aneurysm dome is feasible. This could lead to more effective and a safer IA treatment using FDs. PMID:26869741

  13. Microscopic Approaches to Decomposition and Burning Processes of a Micro Plastic Resin Particle under Abrupt Heating

    NASA Astrophysics Data System (ADS)

    Ohiwa, Norio; Ishino, Yojiro; Yamamoto, Atsunori; Yamakita, Ryuji

    To elucidate the possibility and availability of thermal recycling of waste plastic resin from a basic and microscopic viewpoint, a series of abrupt heating processes of a spherical micro plastic particle having a diameter of about 200 μm is observed, when it is abruptly exposed to hot oxidizing combustion gas. Three ingenious devices are introduced and two typical plastic resins of polyethylene terephthalate and polyethylene are used. In this paper the dependency of internal and external appearances of residual plastic embers on the heating time and the ingredients of plastic resins is optically analyzed, along with appearances of internal micro bubbling, multiple micro explosions and jets, and micro diffusion flames during abrupt heating. Based on temporal variations of the surface area of a micro plastic particle, the apparent burning rate constant is also evaluated and compared with those of well-known volatile liquid fuels.

  14. Conclusive evidence of abrupt coagulation inside the void during cyclic nanoparticle formation in reactive plasma

    NASA Astrophysics Data System (ADS)

    van de Wetering, F. M. J. H.; Nijdam, S.; Beckers, J.

    2016-07-01

    In this letter, we present scanning electron microscopy (SEM) results that confirm in a direct way our earlier explanation of an abrupt coagulation event as the cause for the void hiccup. In a recent paper, we reported on the fast and interrupted expansion of voids in a reactive dusty argon-acetylene plasma. The voids appeared one after the other, each showing a peculiar, though reproducible, behavior of successive periods of fast expansion, abrupt contraction, and continued expansion. The abrupt contraction was termed "hiccup" and was related to collective coagulation of a new generation of nanoparticles growing in the void using relatively indirect methods: electron density measurements and optical emission spectroscopy. In this letter, we present conclusive evidence using SEM of particles collected at different moments in time spanning several growth cycles, which enables us to follow the nanoparticle formation process in great detail.

  15. Gradual onset and recovery of the Younger Dryas abrupt climate event in the tropics

    PubMed Central

    Partin, J.W.; Quinn, T.M.; Shen, C.-C.; Okumura, Y.; Cardenas, M.B.; Siringan, F.P.; Banner, J.L.; Lin, K.; Hu, H.-M.; Taylor, F.W.

    2015-01-01

    Proxy records of temperature from the Atlantic clearly show that the Younger Dryas was an abrupt climate change event during the last deglaciation, but records of hydroclimate are underutilized in defining the event. Here we combine a new hydroclimate record from Palawan, Philippines, in the tropical Pacific, with previously published records to highlight a difference between hydroclimate and temperature responses to the Younger Dryas. Although the onset and termination are synchronous across the records, tropical hydroclimate changes are more gradual (>100 years) than the abrupt (10–100 years) temperature changes in the northern Atlantic Ocean. The abrupt recovery of Greenland temperatures likely reflects changes in regional sea ice extent. Proxy data and transient climate model simulations support the hypothesis that freshwater forced a reduction in the Atlantic meridional overturning circulation, thereby causing the Younger Dryas. However, changes in ocean overturning may not produce the same effects globally as in Greenland. PMID:26329911

  16. Abrupt onset of tongue deformation and phase space response of ions in magnetically-confined plasmas

    PubMed Central

    Ida, K.; Kobayashi, T.; Itoh, K.; Yoshinuma, M.; Tokuzawa, T.; Akiyama, T.; Moon, C.; Tsuchiya, H.; Inagaki, S.; Itoh, S.-I.

    2016-01-01

    An abrupt onset of the new tongue-shaped deformation of magnetic surface in magnetized plasmas, which was conjectured in since the 1960s but has not been observed, is experimentally identified just before an abrupt onset of a large-scale collapse event. Two novel properties of the event are identified. First, the transition of symmetry of perturbation (rather than a growth of linearly unstable MHD modes) was found to be a key for the onset of abrupt collapse, i.e., the transition of symmetry gives a new route to the collapse from stable state. Second, as a phase-space response of ions, the distortion from Maxwell-Boltzmann distribution of epithermal ions was observed for the first time. PMID:27796370

  17. Novel insights into molecular mechanisms of abruption-induced preterm birth

    PubMed Central

    Buhimschi, Catalin S.; Schatz, Frederik; Krikun, Graciela; Buhimschi, Irina A.; Lockwood, Charles J.

    2015-01-01

    Preterm birth (PTB) complicates more than 12% of all deliveries. Despite significant research, the aetiology of most cases of PTB remains elusive. Two major antecedents of PTB, intra-amniotic infection and decidual haemorrhage (abruption), can exhibit dissimilar demographic and genetic predispositions, despite sharing common molecular and cellular pathways. The use of high-throughput, high-dimensional technologies reveals substantial crosstalk between the coagulation and inflammation pathways. Tissue factor, thrombin and cytokines are key mediators of this crosstalk. Abruptions are associated with excess thrombin generated from decidual-cell-expressed tissue factor. Although thrombin is a primary mediator of the coagulation cascade, it can also promote inflammation-associated PTB by enhancing expression of matrix metalloproteinase and neutrophil-chemoattracting and -activating chemokines. Here, we provide novel insights into the molecular mechanisms and pathways leading to PTB in the setting of placental abruption. PMID:21040617

  18. The Necessity of Awareness of Early Symptoms of Placental Abruption Among Pregnant Japanese Women

    PubMed Central

    Suzuki, Shunji; Shinmura, Hiroki

    2016-01-01

    Background In 2012, the recommendation for immediate contact and visit to obstetric institutions by pregnant women was emphasized by The Japan Obstetric Compensation System for Cerebral Palsy (JOCSC). In this study, we examined whether or not the increased awareness has led to the improvement of perinatal outcomes of placental abruption managed at private clinics. Methods We reviewed the obstetric records of 38 singleton pregnant women complicated by placental abruption that developed at home, and were managed at private clinics from April 2008 through April 2016. Results The perinatal outcomes, specifically the rate of cases with ≥ 1 hour time interval between symptom onset and clinic visit, have not changed significantly after the intervention. Conclusion The provision of information regarding the early clinical symptoms associated with placental abruption in pregnant women has not been well documented in Japan. PMID:27540442

  19. Gradual onset and recovery of the Younger Dryas abrupt climate event in the tropics

    NASA Astrophysics Data System (ADS)

    Partin, J. W.; Quinn, T. M.; Shen, C.-C.; Okumura, Y.; Cardenas, M. B.; Siringan, F. P.; Banner, J. L.; Lin, K.; Hu, H.-M.; Taylor, F. W.

    2015-09-01

    Proxy records of temperature from the Atlantic clearly show that the Younger Dryas was an abrupt climate change event during the last deglaciation, but records of hydroclimate are underutilized in defining the event. Here we combine a new hydroclimate record from Palawan, Philippines, in the tropical Pacific, with previously published records to highlight a difference between hydroclimate and temperature responses to the Younger Dryas. Although the onset and termination are synchronous across the records, tropical hydroclimate changes are more gradual (>100 years) than the abrupt (10-100 years) temperature changes in the northern Atlantic Ocean. The abrupt recovery of Greenland temperatures likely reflects changes in regional sea ice extent. Proxy data and transient climate model simulations support the hypothesis that freshwater forced a reduction in the Atlantic meridional overturning circulation, thereby causing the Younger Dryas. However, changes in ocean overturning may not produce the same effects globally as in Greenland.

  20. Abrupt climate change in southeast tropical Africa influenced by Indian monsoon variability and ITCZ migration

    NASA Astrophysics Data System (ADS)

    Tierney, Jessica E.; Russell, James M.

    2007-08-01

    The timing and magnitude of abrupt climate change in tropical Africa during the last glacial termination remains poorly understood. High-resolution paleolimnological data from Lake Tanganyika, Southeast Africa show that wind-driven seasonal mixing in the lake was reduced during the Younger Dryas, Inter-Allerød Cool Period, Older Dryas, and Heinrich Event 1, suggesting a weakened southwest Indian monsoon and a more southerly position of the Inter-Tropical Convergence Zone over Africa during these intervals. These events in Lake Tanganyika, coeval with millennial and centennial-scale climate shifts in the high latitudes, suggest that changes in ITCZ location and Indian monsoon strength are important components of abrupt global climate change and that their effects are felt south of the equator in Africa. However, we observe additional events in Lake Tanganyika of equal magnitude that are not correlated with high-latitude changes, indicating the potential for abrupt climate change to originate from within tropical systems.

  1. Abrupt change of Antarctic moisture origin at the end of Termination II.

    PubMed

    Masson-Delmotte, V; Stenni, B; Blunier, T; Cattani, O; Chappellaz, J; Cheng, H; Dreyfus, G; Edwards, R L; Falourd, S; Govin, A; Kawamura, K; Johnsen, S J; Jouzel, J; Landais, A; Lemieux-Dudon, B; Lourantou, A; Marshall, G; Minster, B; Mudelsee, M; Pol, K; Röthlisberger, R; Selmo, E; Waelbroeck, C

    2010-07-01

    The deuterium excess of polar ice cores documents past changes in evaporation conditions and moisture origin. New data obtained from the European Project for Ice Coring in Antarctica Dome C East Antarctic ice core provide new insights on the sequence of events involved in Termination II, the transition between the penultimate glacial and interglacial periods. This termination is marked by a north-south seesaw behavior, with first a slow methane concentration rise associated with a strong Antarctic temperature warming and a slow deuterium excess rise. This first step is followed by an abrupt north Atlantic warming, an abrupt resumption of the East Asian summer monsoon, a sharp methane rise, and a CO(2) overshoot, which coincide within dating uncertainties with the end of Antarctic optimum. Here, we show that this second phase is marked by a very sharp Dome C centennial deuterium excess rise, revealing abrupt reorganization of atmospheric circulation in the southern Indian Ocean sector.

  2. Gradual onset and recovery of the Younger Dryas abrupt climate event in the tropics.

    PubMed

    Partin, J W; Quinn, T M; Shen, C-C; Okumura, Y; Cardenas, M B; Siringan, F P; Banner, J L; Lin, K; Hu, H-M; Taylor, F W

    2015-09-02

    Proxy records of temperature from the Atlantic clearly show that the Younger Dryas was an abrupt climate change event during the last deglaciation, but records of hydroclimate are underutilized in defining the event. Here we combine a new hydroclimate record from Palawan, Philippines, in the tropical Pacific, with previously published records to highlight a difference between hydroclimate and temperature responses to the Younger Dryas. Although the onset and termination are synchronous across the records, tropical hydroclimate changes are more gradual (>100 years) than the abrupt (10-100 years) temperature changes in the northern Atlantic Ocean. The abrupt recovery of Greenland temperatures likely reflects changes in regional sea ice extent. Proxy data and transient climate model simulations support the hypothesis that freshwater forced a reduction in the Atlantic meridional overturning circulation, thereby causing the Younger Dryas. However, changes in ocean overturning may not produce the same effects globally as in Greenland.

  3. Antiretroviral restriction factors.

    PubMed

    Hatziioannou, Theodora; Bieniasz, Paul D

    2011-12-01

    Studies of retroviruses have been instrumental in revealing the existence of an array of antiviral proteins, or restriction factors, and the mechanisms by which they function. Some restriction factors appear to specifically inhibit retrovirus replication, while others have a broader antiviral action. Here, we briefly review current understanding of the mechanisms by which several such proteins exert antiviral activity. We also discuss how retroviruses have evolved to evade or antagonize antiviral proteins, including through the action of viral accessory proteins. Restriction factors, their viral targets and antagonists have exerted evolutionary pressure on each other, resulting in specialization and barriers to cross-species transmission. Potentially, this recently revealed intrinsic system of antiviral immunity might be mobilized for therapeutic benefit.

  4. Myocardial infarction complicated by left ventricular thrombus and fatal thromboembolism following abrupt cessation of dabigatran.

    PubMed

    Weiler, Bethany; Marciniak, Ellen T; Reed, Robert M; McCurdy, Michael T

    2014-07-04

    Novel anticoagulants are increasingly utilised in lieu of warfarin to treat non-valvular atrial fibrillation. Their clinical use in other non-FDA approved settings is also increasing. We present a case in which a patient abruptly stopped taking dabigatran due to a small bowel obstruction and shortly thereafter suffered a myocardial infarction complicated by left ventricular thrombosis with fatal embolisation to the superior mesenteric artery. In this context, we discuss the possibility of a rebound phenomenon of hypercoagulability with abrupt cessation of novel anticoagulants.

  5. Phase-locked states and abrupt shifts in Pacific climate indices

    NASA Astrophysics Data System (ADS)

    Douglass, David H.

    2013-10-01

    Douglass has shown that ENSO index aNino3.4 contains segments phase locked to subharmonics of the annual solar cycle and also that a set of indices including aNino3.4 shows abrupt shifts between these phase-locked states. Here, four additional Pacific indices are studied. These five indices show that the Pacific climate system alternates between two regimes: (1) Solar cycle (SOL), (2) Teleconnections (TEL). During SOL each index shows two components that are phase locked to the solar cycle. The first is at the annual cycle, while the second is at a subharmonic of the annual cycle. During TEL abrupt climate shifts occur.

  6. New evidence from the South China Sea for an abrupt termination of the last glacial period

    NASA Technical Reports Server (NTRS)

    Broecker, W. S.; Klas, M.; Andree, M.; Bonani, G.; Wolfli, W.

    1988-01-01

    Results demonstrating an abrupt change in the rate and character of sedimentation in the South China Sea at the close of the last glacial period are presented. Radiocarbon dating and its position in the oxygen isotope shift suggest that this change may be coincident with the abrupt change in climatic conditions seen at high latitudes in the North Atlantic and the Antarctic at 13 kyr BP. These results support the contention that a major global climatic change occurred between 14 and 13 kyr BP.

  7. Neuroaesthetics: range and restrictions.

    PubMed

    Chatterjee, Anjan

    2013-04-01

    Bullot & Reber (B&R) should be commended for highlighting tensions between scientific aesthetics and art history. The question of how each tradition can learn from the other is timely. While I am sympathetic to their views, their diagnosis of the problem appears exaggerated and their solution partial. They underestimate the reach of scientific aesthetics while failing to identify its inherent restrictions. PMID:23507092

  8. Has the Golden Age of American Higher Education Come to an Abrupt End?

    ERIC Educational Resources Information Center

    Witmer, David R.

    1980-01-01

    The author discusses why he feels that the golden age of higher education has not come to an abrupt end, from the point of view of research, instruction, public service, income data, costs of education, and the social rate of return on investment in college education for women and men. (CT)

  9. Dynamics of climate and ecosystem coupling: abrupt changes and multiple equilibria.

    PubMed Central

    Higgins, Paul A T; Mastrandrea, Michael D; Schneider, Stephen H

    2002-01-01

    Interactions between subunits of the global climate-biosphere system (e.g. atmosphere, ocean, biosphere and cryosphere) often lead to behaviour that is not evident when each subunit is viewed in isolation. This newly evident behaviour is an emergent property of the coupled subsystems. Interactions between thermohaline circulation and climate illustrate one emergent property of coupling ocean and atmospheric circulation. The multiple thermohaline circulation equilibria that result caused abrupt climate changes in the past and may cause abrupt climate changes in the future. Similarly, coupling between the climate system and ecosystem structure and function produces complex behaviour in certain regions. For example, atmosphere-biosphere interactions in the Sahel region of West Africa lead to multiple stable equilibria. Either wet or dry climate equilibria can occur under otherwise identical forcing conditions. The equilibrium reached is dependent on past history (i.e. initial conditions), and relatively small perturbations to either climate or vegetation can cause switching between the two equilibria. Both thermohaline circulation and the climate-vegetation system in the Sahel are prone to abrupt changes that may be irreversible. This complicates the relatively linear view of global changes held in many scientific and policy communities. Emergent properties of coupled socio-natural systems add yet another layer of complexity to the policy debate. As a result, the social and economic consequences of possible global changes are likely to be underestimated in most conventional analyses because these nonlinear, abrupt and irreversible responses are insufficiently considered. PMID:12079526

  10. Dynamics of climate and ecosystem coupling: abrupt changes and multiple equilibria.

    PubMed

    Higgins, Paul A T; Mastrandrea, Michael D; Schneider, Stephen H

    2002-05-29

    Interactions between subunits of the global climate-biosphere system (e.g. atmosphere, ocean, biosphere and cryosphere) often lead to behaviour that is not evident when each subunit is viewed in isolation. This newly evident behaviour is an emergent property of the coupled subsystems. Interactions between thermohaline circulation and climate illustrate one emergent property of coupling ocean and atmospheric circulation. The multiple thermohaline circulation equilibria that result caused abrupt climate changes in the past and may cause abrupt climate changes in the future. Similarly, coupling between the climate system and ecosystem structure and function produces complex behaviour in certain regions. For example, atmosphere-biosphere interactions in the Sahel region of West Africa lead to multiple stable equilibria. Either wet or dry climate equilibria can occur under otherwise identical forcing conditions. The equilibrium reached is dependent on past history (i.e. initial conditions), and relatively small perturbations to either climate or vegetation can cause switching between the two equilibria. Both thermohaline circulation and the climate-vegetation system in the Sahel are prone to abrupt changes that may be irreversible. This complicates the relatively linear view of global changes held in many scientific and policy communities. Emergent properties of coupled socio-natural systems add yet another layer of complexity to the policy debate. As a result, the social and economic consequences of possible global changes are likely to be underestimated in most conventional analyses because these nonlinear, abrupt and irreversible responses are insufficiently considered.

  11. Dynamics of climate and ecosystem coupling: abrupt changes and multiple equilibria.

    PubMed

    Higgins, Paul A T; Mastrandrea, Michael D; Schneider, Stephen H

    2002-05-29

    Interactions between subunits of the global climate-biosphere system (e.g. atmosphere, ocean, biosphere and cryosphere) often lead to behaviour that is not evident when each subunit is viewed in isolation. This newly evident behaviour is an emergent property of the coupled subsystems. Interactions between thermohaline circulation and climate illustrate one emergent property of coupling ocean and atmospheric circulation. The multiple thermohaline circulation equilibria that result caused abrupt climate changes in the past and may cause abrupt climate changes in the future. Similarly, coupling between the climate system and ecosystem structure and function produces complex behaviour in certain regions. For example, atmosphere-biosphere interactions in the Sahel region of West Africa lead to multiple stable equilibria. Either wet or dry climate equilibria can occur under otherwise identical forcing conditions. The equilibrium reached is dependent on past history (i.e. initial conditions), and relatively small perturbations to either climate or vegetation can cause switching between the two equilibria. Both thermohaline circulation and the climate-vegetation system in the Sahel are prone to abrupt changes that may be irreversible. This complicates the relatively linear view of global changes held in many scientific and policy communities. Emergent properties of coupled socio-natural systems add yet another layer of complexity to the policy debate. As a result, the social and economic consequences of possible global changes are likely to be underestimated in most conventional analyses because these nonlinear, abrupt and irreversible responses are insufficiently considered. PMID:12079526

  12. A study of the early warning signals of abrupt change in the Pacific decadal oscillation

    NASA Astrophysics Data System (ADS)

    Wu, Hao; Hou, Wei; Yan, Peng-Cheng; Zhang, Zhi-Sen; Wang, Kuo

    2015-08-01

    In recent years, the phenomenon of a critical slowing down has demonstrated its major potential in discovering whether a complex dynamic system tends to abruptly change at critical points. This research on the Pacific decadal oscillation (PDO) index has been made on the basis of the critical slowing down principle in order to analyze its early warning signal of abrupt change. The chaotic characteristics of the PDO index sequence at different times are determined by using the largest Lyapunov exponent (LLE). The relationship between the regional sea surface temperature (SST) background field and the early warning signal of the PDO abrupt change is further studied through calculating the variance of the SST in the PDO region and the spatial distribution of the autocorrelation coefficient, thereby providing the experimental foundation for the extensive application of the method of the critical slowing down phenomenon. Our results show that the phenomenon of critical slowing down, such as the increase of the variance and autocorrelation coefficient, will continue for six years before the abrupt change of the PDO index. This phenomenon of the critical slowing down can be regarded as one of the early warning signals of an abrupt change. Through calculating the LLE of the PDO index during different times, it is also found that the strongest chaotic characteristics of the system occurred between 1971 and 1975 in the early stages of an abrupt change (1976), and the system was at the stage of a critical slowing down, which proves the reliability of the early warning signal of abrupt change discovered in 1970 from the mechanism. In addition, the variance of the SST, along with the spatial distribution of the autocorrelation coefficient in the corresponding PDO region, also demonstrates the corresponding relationship between the change of the background field of the SST and the change of the PDO. Project supported by the National Natural Science Foundation of China (Grant Nos

  13. Transient Simulation of the Evolution and Abrupt Change of Northern Africa Atmosphere-Ocean-Terrestrial Ecosystem in the Holocene: What causes the abrupt change?

    NASA Astrophysics Data System (ADS)

    Liu, Z.; Wang, Y.; Gallimore, R.; Gasse, F.; Johnson, T.; Demenocal, P.; Adkins, J.; Notaro, M.; Prentice, C.; Kutzbach, J.; Jacob, R.; Behling, P.; Ong, E.; Wang, L.

    2006-12-01

    We present the first synchronously coupled transient simulation of the evolution of northern Africa climate- ecosystem for the last 6500 years in a global general circulation ocean-atmosphere-terrestrial ecosystem model. The model successfully simulated the major abrupt vegetation collapse in the southern Sahara at about 5ka, consistent with the proxy records. Local precipitation, however, shows a much more gradual decline with time. The vegetation change in northern Africa is clearly driven by local precipitation decline and strong precipitation variability. In contrast, the change of precipitation is dominated by internal climate variability and a gradual monsoonal climate response to orbital forcing. In addition, some minor vegetation changes are also simulated in different regions across northern Africa. The model simulated a reduced seasonal cycle of SST and a gradual annual mean surface cooling in the subtropical North Atlantic towards the latest Holocene. The SST response is caused largely by the insolation forcing, while the annual mean cooling is also reinforced by the increased coastal upwelling near the east boundary. The increased upwelling results from a southward retreat of the North Africa monsoon system, and, in turn, an increased northeasterly trade wind. The simulated changes of SST and upwelling are also largely consistent with recent marine proxy records, albeit with a weaker magnitude in the model. A further analysis of the mechanism of the abrupt vegetation collapse suggests that the abrupt vegetation collapse is caused by a strong decadal climate variability in a stable climate-ecosystem, rather than a positive vegetation-climate feedback on a multi-equilibrium system. We propose that strong climate variability can induce a dramatic vegetation collapse with a gradual reduction in precipitation during the mid-Holocene. Our study highlights climate variability as a critical forcing for the vegetation collapse in both models and the real world.

  14. License restrictions at Barnwell

    SciTech Connect

    Autry, V.R.

    1991-12-31

    The State of South Carolina was delegated the authority by the US Nuclear Regulatory Commission to regulate the receipt, possession, use and disposal of radioactive material as an Agreement State. Since 1970, the state has been the principal regulatory authority for the Barnwell Low-Level Waste Disposal Facility operated by Chem-Nuclear Systems, Inc. The radioactive material license issued authorizing the receipt and disposal of low-level waste contains numerous restrictions to ensure environmental protection and compliance with shallow land disposal performance criteria. Low-level waste has evolved from minimally contaminated items to complex waste streams containing high concentrations of radionuclides and processing chemicals which necessitated these restrictions. Additionally, some waste with their specific radionuclides and concentration levels, many classified as low-level radioactive waste, are not appropriate for shallow land disposal unless additional precautions are taken. This paper will represent a number of these restrictions, the rationale for them, and how they are being dealt with at the Barnwell disposal facility.

  15. Hydrologic effects of annually diverting 131,000 acre-feet of water from Dillon Reservoir, central Colorado

    USGS Publications Warehouse

    Alley, William M.; Bauer, D.P.; Veenhuis, J.E.; Brennan, Robert

    1979-01-01

    Because of the increased demands for water in eastern Colorado, principally in the urbanizing Denver metropolitan area, increased diversions of water from Dillon Reservoir are planned. Estimates of end-of-month storage in Dillon Reservoir, assuming the reservoir was in place and 131,000 acre-feet of water were diverted from the reservoir each year, were reconstructed by mass balance for the 1931-77 water years. Based on the analysis, the annual maximum end-of-month drawdown below the elevation at full storage would have averaged 54 feet. The maximum end-of-month drawdown below the elevation at full storage would have been 171 feet. The mean-annual discharge-weighted dissolved-solids concentrations in the Colorado River near Glenwood Springs and Cameo, Colo., and Cisco, Utah, for the 1942-77 water years, were computed assuming an annual diversion of 131,000 acre-feet of water from Dillon Reservoir. The average increases in the dissolved-solids concentrations with the 131 ,000-acre-foot diversion were 15 to 16 milligrams per liter at the three sites. (Woodard-USGS)

  16. Inactivation of Pathogens in Feces by Desiccation and Urea Treatment for Application in Urine-Diverting Dry Toilets

    PubMed Central

    Philippi, Luiz Sérgio; Vinnerås, Björn

    2013-01-01

    Ecological sanitation technologies can be effective in providing health and environmental pollution control if they can efficiently reduce the pathogenicity of microorganisms carried in fecal material to safe levels. This study evaluated the sanitizing effects of different additives for dry treatment of feces from urine-diverting dry toilets, based on inactivation of Enterococcus faecalis, Salmonella enterica serovar Typhimurium, bacteriophages MS2 and ΦX, and Ascaris suum. The additives, ash (A) and oyster shell (O) in different amounts and urea (U) to optimize the process, were compared with no additive, solely urea, and sawdust as controls (C) and were covered ([x%O:A]) or uncovered (x%O:A). The main inactivation factors found were desiccation, ammonia content, and pH. S. Typhimurium and E. faecalis were more affected by the ammonia content. A combination of neutral to high pH and desiccation was most effective for inactivation of MS2, and desiccation was most effective for inactivation of ΦX and A. suum. The inactivation rate was modeled for all combinations studied. The most promising treatments were [150%O:A+U], 150%O:A+U, and 150%O:A. According to the models, these could inactivate, for example, 7 log10 units of all bacteria and bacteriophages within 83, 125, and 183 days, respectively. The inactivation of A. suum was modeled, albeit the measured decay in egg viability was low. PMID:23335764

  17. Analysis of shot-to-shot variability in post-disruption runaway electron currents for diverted DIII-D discharges

    NASA Astrophysics Data System (ADS)

    Izzo, V. A.; Humphreys, D. A.; Kornbluth, M.

    2012-09-01

    In DIII-D experiments, rapid termination by Ar-pellet injection sometimes produces a post-termination runaway electron (RE) current plateau, but this effect is highly non-reproducible on a shot-to-shot basis, particularly for diverted target plasmas. A set of DIII-D discharges is analyzed with two MHD codes to understand the relationship between the current profile of the target plasma and the amplitude of the RE current plateau. Using the linear stability code GATO, a correlation between the radial profile of the unstable n = 1 mode just after Ar-pellet injection and the observed appearance of an RE plateau is identified. Nonlinear NIMROD simulations with RE test-particle calculations directly predict RE confinement times during the disruption. With one exception, NIMROD predicts better RE confinement for shots in which higher RE currents were observed in DIII-D. But, the variation in confinement is primarily connected to the saturated n = 1 mode amplitude and not its radial profile. Still, both sets of analyses support the hypothesis that RE deconfinement by MHD fluctuations is a major factor in the shot-to-shot variability of RE plateaus, though additional factors such as seed current amplitude cannot be ruled out.

  18. Can the elongated hindwing tails of fluttering moths serve as false sonar targets to divert bat attacks?

    PubMed

    Lee, Wu-Jung; Moss, Cynthia F

    2016-05-01

    It has long been postulated that the elongated hindwing tails of many saturniid moths have evolved to create false sonar targets to divert the attack of echolocation-guided bat predators. However, rigorous echo-acoustic evidence to support this hypothesis has been lacking. In this study, fluttering luna moths (Actias luna), a species with elongated hindwing tails, were ensonified with frequency modulated chirp signals from all angles of orientation and across the wingbeat cycle. High-speed stereo videography was combined with pulse compression sonar processing to characterize the echo information available to foraging bats. Contrary to previous suggestions, the results show that the tail echoes are weak and do not dominate the sonar returns, compared to the large, planar wings and the moth body. However, the distinctive twisted morphology of the tails create persistent echoes across all angles of orientation, which may induce erroneous sonar target localization and disrupt accurate tracking by echolocating bats. These findings thus suggest a refinement of the false target hypothesis to emphasize sonar localization errors induced by the twisted tails, and highlight the importance of physics-based approaches to study the sensory information involved in the evolutionary arms race between moths and their bat predators. PMID:27250152

  19. Ethanol Diverts Early Neuronal Differentiation Trajectory of Embryonic Stem Cells by Disrupting the Balance of Lineage Specifiers

    PubMed Central

    Sánchez-Alvarez, Rosa; Gayen, Saurabh; Vadigepalli, Rajanikanth; Anni, Helen

    2013-01-01

    Background Ethanol is a toxin responsible for the neurodevelopmental deficits of Fetal Alcohol Spectrum Disorders (FASD). Recent evidence suggests that ethanol modulates the protein expression of lineage specifier transcription factors Oct4 (Pou5f1) and Sox2 in early stages of mouse embryonic stem (ES) cell differentiation. We hypothesized that ethanol induced an imbalance in the expression of Oct4 and Sox2 in early differentiation, that dysregulated the expression of associated and target genes and signaling molecules and diverted cells from neuroectodermal (NE) formation. Methodology/Principal Findings We showed modulation by ethanol of 33 genes during ES cell differentiation, using high throughput microfluidic dynamic array chips measuring 2,304 real time quantitative PCR assays. Based on the overall gene expression dynamics, ethanol drove cells along a differentiation trajectory away from NE fate. These ethanol-induced gene expression changes were observed as early as within 2 days of differentiation, and were independent of cell proliferation or apoptosis. Gene expression changes were correlated with fewer βIII-tubulin positive cells of an immature neural progenitor phenotype, as well as a disrupted actin cytoskeleton were observed. Moreover, Tuba1a and Gapdh housekeeping genes were modulated by ethanol during differentiation and were replaced by a set of ribosomal genes with stable expression. Conclusions/Significance These findings provided an ethanol-response gene signature and pointed to the transcriptional dynamics underlying lineage imbalance that may be relevant to FASD phenotype. PMID:23724002

  20. Can the elongated hindwing tails of fluttering moths serve as false sonar targets to divert bat attacks?

    PubMed

    Lee, Wu-Jung; Moss, Cynthia F

    2016-05-01

    It has long been postulated that the elongated hindwing tails of many saturniid moths have evolved to create false sonar targets to divert the attack of echolocation-guided bat predators. However, rigorous echo-acoustic evidence to support this hypothesis has been lacking. In this study, fluttering luna moths (Actias luna), a species with elongated hindwing tails, were ensonified with frequency modulated chirp signals from all angles of orientation and across the wingbeat cycle. High-speed stereo videography was combined with pulse compression sonar processing to characterize the echo information available to foraging bats. Contrary to previous suggestions, the results show that the tail echoes are weak and do not dominate the sonar returns, compared to the large, planar wings and the moth body. However, the distinctive twisted morphology of the tails create persistent echoes across all angles of orientation, which may induce erroneous sonar target localization and disrupt accurate tracking by echolocating bats. These findings thus suggest a refinement of the false target hypothesis to emphasize sonar localization errors induced by the twisted tails, and highlight the importance of physics-based approaches to study the sensory information involved in the evolutionary arms race between moths and their bat predators.

  1. Diverting the Radicalization Track

    ERIC Educational Resources Information Center

    Cohen, Jared A.

    2009-01-01

    The struggle against violent extremism is the most significant national-security challenge of the 21st century. It is the challenge that makes all the threats Americans face that much more dangerous. The ungoverned spaces, urban slums, and impoverished regions of the Middle East, Asia, and Africa, along with the poorly integrated immigrant…

  2. HiFiVS Modeling of Flow Diverter Deployment Enables Hemodynamic Characterization of Complex Intracranial Aneurysm Cases

    PubMed Central

    Xiang, Jianping; Damiano, Robert J.; Lin, Ning; Snyder, Kenneth V.; Siddiqui, Adnan H.; Levy, Elad I.; Meng, Hui

    2016-01-01

    reduction (decrease by 77.7%, 53.0%, and 84.4% in average velocity, inflow rate and average WSS, respectively, and increase to 213.0% in turnover time) than Aneurysm III-a, which qualitatively agreed with angiographic observation at 3-month follow-up. However, Aneurysm III-b remained patent at both 6 months and 9 months. A closer examination of the vascular anatomy of Case III revealed blood draining to the ophthalmic artery off Aneurysm III-b, which may have prevented its complete thrombosis. Conclusion This proof-of-concept study demonstrates that HiFiVE modeling of flow diverter deployment enables detailed characterization of hemodynamic alteration by PED placement. Post-treatment aneurysmal flow reduction may be correlated with aneurysm occlusion outcome. However, predicting aneurysm treatment outcome by flow diverters also requires consideration of other factors including vascular anatomy. PMID:26090829

  3. Flight investigation of an underwing nacelle installation of an auxiliary-inlet ejector nozzle with a clamshell flow diverter from Mach 0.6 to 1.3

    NASA Technical Reports Server (NTRS)

    Head, V. L.

    1972-01-01

    A nozzle installation of general interest is a podded engine mounted near the aft lower surface of the wing. The effect of this installation on the performance of an auxiliary-inlet ejector nozzle with a clamshell flow diverter was investigated over a Mach number range of 0.6 to 1.3 by using a modified F-106B aircraft. The clamshell flow diverter was tested in a 17 deg position with double-hinged synchronized floating doors. The ejector nozzle trailing-edge flaps were simulated in the closed position with a rigid structure which provided a boattail angle of 10 deg. Primary nozzle area was varied as exhaust gas temperature was varied between 975 and 1561 K. With the nozzle in a subsonic cruise position, the nozzle gross thrust coefficient was 0.918 at a flight Mach number of 0.9.

  4. Does the trigger for abrupt climate change reside in the ocean or in the atmosphere?

    PubMed

    Broecker, W S

    2003-06-01

    Two hypotheses have been put forward to explain the large and abrupt climate changes that punctuated glacial time. One attributes such changes to reorganizations of the ocean's thermohaline circulation and the other to changes in tropical atmosphere-ocean dynamics. In an attempt to distinguish between these hypotheses, two lines of evidence are examined. The first involves the timing of the freshwater injections to the northern Atlantic that have been suggested as triggers for the global impacts associated with the Younger Dryas and Heinrich events. The second has to do with evidence for precursory events associated with the Heinrich ice-rafted debris layers in the northern Atlantic and with the abrupt Dansgaard-Oeschger warmings recorded in the Santa Barbara Basin.

  5. Globally synchronous ice core volcanic tracers and abrupt cooling during the last glacial period

    USGS Publications Warehouse

    Bay, R.C.; Bramall, N.E.; Price, P.B.; Clow, G.D.; Hawley, R.L.; Udisti, R.; Castellano, E.

    2006-01-01

    We perform a Monte Carlo pattern recognition analysis of the coincidence between three regional volcanic histories from ice coring of Greenland and Antarctica over the period 2 to 45 ka, using SO4 anomalies in Greenland and East Antarctica determined by continuous core chemistry, together with West Antarctic volcanic ash layers determined by remote optical borehole logging and core assays. We find that the Antarctic record of volcanism correlates with Glacial abrupt climate change at a 95% to >99.8% (???3??) significance level and that volcanic depositions at the three locations match at levels exceeding 3??, likely indicating that many common horizons represent single eruptive events which dispersed material world wide. These globally coincident volcanics were associated with abrupt cooling, often simultaneous with onsets or sudden intensifications of millennial cold periods. The striking agreement between sites implies that the consistency of current timescales obtained by isotopic and glaciological dating methods is better than estimated. Copyright 2006 by the American Geogphysical Union.

  6. Characterizing abrupt changes in the stock prices using a wavelet decomposition method

    NASA Astrophysics Data System (ADS)

    Caetano, Marco Antonio Leonel; Yoneyama, Takashi

    2007-09-01

    Abrupt changes in the stock prices, either upwards or downwards, are usually preceded by an oscillatory behavior with frequencies that tend to increase as the moment of transition becomes closer. The wavelet decomposition methods may be useful for analysis of this oscillations with varying frequencies, because they provide simultaneous information on the frequency (scale) and localization in time (translation). However, in order to use the wavelet decomposition, certain requirements have to be satisfied, so that the linear and cyclic trends are eliminated by standard least squares techniques. The coefficients obtained by the wavelet decomposition can be represented in a graphical form. A threshold can then be established to characterize the likelihood of a short-time abrupt change in the stock prices. Actual data from the São Paulo Stock Exchange (Bolsa de Valores de São Paulo) were used in this work to illustrate the proposed method.

  7. Abrupt GaP/Si hetero-interface using bistepped Si buffer

    SciTech Connect

    Ping Wang, Y. Kuyyalil, J.; Nguyen Thanh, T.; Almosni, S.; Bernard, R.; Tremblay, R.; Da Silva, M.; Létoublon, A.; Rohel, T.; Tavernier, K.; Le Corre, A.; Cornet, C.; Durand, O.; Stodolna, J.; Ponchet, A.; Bahri, M.; Largeau, L.; Patriarche, G.; Magen, C.

    2015-11-09

    We evidence the influence of the quality of the starting Si surface on the III-V/Si interface abruptness and on the formation of defects during the growth of III-V/Si heterogeneous crystal, using high resolution transmission electron microscopy and scanning transmission electron microscopy. GaP layers were grown by molecular beam epitaxy on vicinal Si (001). The strong effect of the Si substrate chemical preparation is first demonstrated by studying structural properties of both Si homoepitaxial layer and GaP/Si heterostructure. It is then shown that choosing adequate chemical preparation conditions and subsequent III-V regrowth conditions enables the quasi-suppression of micro-twins in the epilayer. Finally, the abruptness of GaP/Si interface is found to be very sensitive to the Si chemical preparation and is improved by the use of a bistepped Si buffer prior to III-V overgrowth.

  8. Causes and projections of abrupt climate-driven ecosystem shifts in the North Atlantic.

    PubMed

    Beaugrand, Grégory; Edwards, Martin; Brander, Keith; Luczak, Christophe; Ibanez, Frederic

    2008-11-01

    Warming of the global climate is now unequivocal and its impact on Earth' functional units has become more apparent. Here, we show that marine ecosystems are not equally sensitive to climate change and reveal a critical thermal boundary where a small increase in temperature triggers abrupt ecosystem shifts seen across multiple trophic levels. This large-scale boundary is located in regions where abrupt ecosystem shifts have been reported in the North Atlantic sector and thereby allows us to link these shifts by a global common phenomenon. We show that these changes alter the biodiversity and carrying capacity of ecosystems and may, combined with fishing, precipitate the reduction of some stocks of Atlantic cod already severely impacted by exploitation. These findings offer a way to anticipate major ecosystem changes and to propose adaptive strategies for marine exploited resources such as cod in order to minimize social and economic consequences.

  9. Does the trigger for abrupt climate change reside in the ocean or in the atmosphere?

    PubMed

    Broecker, W S

    2003-06-01

    Two hypotheses have been put forward to explain the large and abrupt climate changes that punctuated glacial time. One attributes such changes to reorganizations of the ocean's thermohaline circulation and the other to changes in tropical atmosphere-ocean dynamics. In an attempt to distinguish between these hypotheses, two lines of evidence are examined. The first involves the timing of the freshwater injections to the northern Atlantic that have been suggested as triggers for the global impacts associated with the Younger Dryas and Heinrich events. The second has to do with evidence for precursory events associated with the Heinrich ice-rafted debris layers in the northern Atlantic and with the abrupt Dansgaard-Oeschger warmings recorded in the Santa Barbara Basin. PMID:12791974

  10. Observation and analysis of abrupt changes in the interplanetary plasma velocity and magnetic field.

    NASA Technical Reports Server (NTRS)

    Martin, R. N.; Belcher, J. W.; Lazarus, A. J.

    1973-01-01

    This paper presents a limited study of the physical nature of abrupt changes in the interplanetary plasma velocity and magnetic field based on 19 day's data from the Pioneer 6 spacecraft. The period was chosen to include a high-velocity solar wind stream and low-velocity wind. Abrupt events were accepted for study if the sum of the energy density in the magnetic field and velocity changes was above a specified minimum. A statistical analysis of the events in the high-velocity solar wind stream shows that Alfvenic changes predominate. This conclusion is independent of whether steady state requirements are imposed on conditions before and after the event. Alfvenic changes do not dominate in the lower-speed wind. This study extends the plasma field evidence for outwardly propagating Alfvenic changes to time scales as small as 1 min (scale lengths on the order of 20,000 km).

  11. Agulhas salt-leakage oscillations during abrupt climate changes of the Late Pleistocene

    NASA Astrophysics Data System (ADS)

    Marino, Gianluca; Zahn, Rainer; Ziegler, Martin; Purcell, Conor; Knorr, Gregor; Hall, Ian R.; Ziveri, Patrizia; Elderfield, Henry

    2013-09-01

    An ensemble of new, high-resolution records of surface ocean hydrography from the Indian-Atlantic oceanic gateway, south of Africa, demonstrates recurrent and high-amplitude salinity oscillations in the Agulhas Leakage area during the penultimate glacial-interglacial cycle. A series of millennial-scale salinification events, indicating strengthened salt leakage into the South Atlantic, appear to correlate with abrupt changes in the North Atlantic climate and Atlantic Meridional Overturning Circulation (AMOC). This interhemispheric coupling, which plausibly involved changes in the Hadley Cell and midlatitude westerlies that impacted the interocean transport at the tip of Africa, suggests that the Agulhas Leakage acted as a source of negative buoyancy for the perturbed AMOC, possibly aiding its return to full strength. Our finding points to the Indian-to-Atlantic salt transport as a potentially important modulator of the AMOC during the abrupt climate changes of the Late Pleistocene.

  12. Evaluation of a Second-Generation Self-Expanding Variable-Porosity Flow Diverter in a Rabbit Elastase Aneurysm Model

    PubMed Central

    Ionita, C.N.; Natarajan, S.K.; Wang, W; Hopkins, L.N.; Levy, E.I.; Siddiqui, A.H.; Bednarek, D.R.; Rudin, S

    2012-01-01

    BACKGROUND AND PURPOSE The self-expanding V-POD is a second-generation flow-diverting device with a low-porosity PTFE patch on a self-expanding microstent. The authors evaluated this device for the treatment of elastase-induced aneurysms in rabbits. MATERIALS AND METHODS Three V-POD types (A, circumferential patch closed-cell stent [n = 9]; B, asymmetric patch closed-cell stent [n = 7]; and C, asymmetric patch open-cell stent [n = 4]) were evaluated by using angiography, conebeam micro-CT, histology, and SEM. Aneurysm flow modifications were expressed in terms of immediate poststent/prestent ratios of maximum CA volume entering the aneurysm dome tracked on procedural angiograms. Flow modifications were correlated with 4 weeks’ follow-up angiographic, micro-CT, histologic, and SEM results. RESULTS Mechanical stent-deployment difficulties in 4 aneurysms (1 type A; 3 type B) led to suboptimal results and exclusion from analysis. Of the remaining 16 aneurysms, 4-week posttreatment angiograms showed no aneurysm filling in 10 (63%), 3 (~19%) had no filling with a small remnant neck, and 3 (~19%) had <0.25 filling. Successfully treated aneurysms (n = 16) demonstrated an immediate poststent/prestent CA maximum volume ratio of 0.13 ± 0.18% (0.0%–0.5%). Favorable contrast-flow modification on immediate angiography after deployment correlated significantly with aneurysm occlusion on follow-up angiography, micro-CT, and histology. The occlusion percentage derived from micro-CT was 96 ± 6.8%. Histology indicated advanced healing (grade ≥3) in the aneurysm dome in 13 of 16 cases. SEM revealed 15 of 16 stents in an advanced state of endothelialization. CONCLUSIONS This study showed the feasibility and effectiveness of V-POD for aneurysm healing in a rabbit elastase model. PMID:21757527

  13. Abrupt Holocene climate change and potential response to solar forcing in western Canada

    NASA Astrophysics Data System (ADS)

    Gavin, Daniel G.; Henderson, Andrew C. G.; Westover, Karlyn S.; Fritz, Sherilyn C.; Walker, Ian R.; Leng, Melanie J.; Hu, Feng Sheng

    2011-05-01

    Several abrupt climate events during the Holocene, including the widely documented oscillation at 8.2 thousand years before present (ka), are attributed to changes in the North Atlantic thermohaline circulation. Additional mechanisms, such as interactions between atmospheric circulation, ice-sheet dynamics, and the influence of solar irradiance, also have been proposed to explain abrupt climatic events, but evidence remains elusive. This study presents evidence from multi-proxy analyses on the Holocene sediments of Eleanor Lake, interior British Columbia. Climatic inferences from our decadal-resolution record of biogenic silica (BSi) abundance are supported by changes in diatom and pollen assemblages from the same core and correlations with existing regional climate records. The BSi record reveals abrupt and persistent climatic shifts at 10.2, 9.3, and 8.5 ka, the latter two of which are coeval with major collapses of the Laurentide Ice Sheet. The record also reveals a short-term cooling at 8.2 ka that is distinct from the 8.5 ka event and similar in magnitude to several other late-Holocene coolings. BSi is correlated with solar-irradiance indices ( r = 0.43-0.61), but the correlation is opposite in sign to that expected from direct solar forcing and weakens after 8 ka. Possible mechanisms causing the abrupt and persistent climate changes of the early Holocene include 1) sudden losses of ice and proglacial lake extent, causing a shift in the meridional structure of atmospheric circulation, 2) a possible link between solar minima and El Niño-like conditions that are correlated with warm spring temperature in interior British Columbia, and 3) the influence of solar irradiance variability on the position of the polar jet, possibly via effects on the strength of the glacial anticyclone.

  14. The abrupt changes in the yellowed fibril density in the Linen of Turin

    NASA Astrophysics Data System (ADS)

    Curciarello, F.; De Leo, V.; Fazio, G.; Mandaglio, G.

    2012-03-01

    The present investigation is an attempt to explain the abrupt changes in the yellowed fibril density (or image intensity) values in the dorsal part of the Shroud of Turin body image. The interested areas are the ones at the base of the shoulders and the buttocks. These rapid changes in the body image intensity are not anomalies of the linen manufacture. They can be explained with the original presence of aromas and/or burial ointments.

  15. Precise interpolar phasing of abrupt climate change during the last ice age

    USGS Publications Warehouse

    ,; Buizert, Christo; Adrian, Betty M.; Ahn, Jinho; Albert, Mary; Alley, Richard B.; Baggenstos, Daniel; Bauska, Thomas K.; Bay, Ryan C.; Bencivengo, Brian B.; Bentley, Charles R.; Brook, Edward J.; Chellman, Nathan J.; Clow, Gary D.; Cole-Dai, Jihong; Conway, Howard; Cravens, Eric; Cuffey, Kurt M.; Dunbar, Nelia W.; Edwards, Jon S.; Fegyveresi, John M.; Ferris, Dave G.; Fitzpatrick, Joan J.; Fudge, T. J.; Gibson, Chris J.; Gkinis, Vasileios; Goetz, Joshua J.; Gregory, Stephanie; Hargreaves, Geoffrey Mill; Iverson, Nels; Johnson, Jay A.; Jones, Tyler R.; Kalk, Michael L.; Kippenhan, Matthew J.; Koffman, Bess G.; Kreutz, Karl; Kuhl, Tanner W.; Lebar, Donald A.; Lee, James E.; Marcott, Shaun A.; Markle, Bradley R.; Maselli, Olivia J.; McConnell, Joseph R.; McGwire, Kenneth C.; Mitchell, Logan E.; Mortensen, Nicolai B.; Neff, Peter D.; Nishiizumi, Kunihiko; Nunn, Richard M.; Orsi, Anais J.; Pasteris, Daniel R.; Pedro, Joel B.; Pettit, Erin C.; Price, P. Buford; Priscu, John C.; Rhodes, Rachael H.; Rosen, Julia L.; Schauer, Andrew J.; Schoenemann, Spruce W.; Sendelbach, Paul J.; Severinghaus, Jeffrey P.; Shturmakov, Alexander J.; Sigl, Michael; Slawny, Kristina R.; Souney, Joseph M.; Sowers, Todd A.; Spencer, Matthew K.; Steig, Eric J.; Taylor, Kendrick C.; Twickler, Mark S.; Vaughn, Bruce H.; Voigt, Donald E.; Waddington, Edwin D.; Welten, Kees C.; Wendricks, Anthony W.; White, James W. C.; Winstrup, Mai; Wong, Gifford J.; Woodruff, Thomas E.

    2015-01-01

    The last glacial period exhibited abrupt Dansgaard–Oeschger climatic oscillations, evidence of which is preserved in a variety of Northern Hemisphere palaeoclimate archives1. Ice cores show that Antarctica cooled during the warm phases of the Greenland Dansgaard–Oeschger cycle and vice versa2, 3, suggesting an interhemispheric redistribution of heat through a mechanism called the bipolar seesaw4, 5, 6. Variations in the Atlantic meridional overturning circulation (AMOC) strength are thought to have been important, but much uncertainty remains regarding the dynamics and trigger of these abrupt events7, 8, 9. Key information is contained in the relative phasing of hemispheric climate variations, yet the large, poorly constrained difference between gas age and ice age and the relatively low resolution of methane records from Antarctic ice cores have so far precluded methane-based synchronization at the required sub-centennial precision2, 3,10. Here we use a recently drilled high-accumulation Antarctic ice core to show that, on average, abrupt Greenland warming leads the corresponding Antarctic cooling onset by 218 ± 92 years (2σ) for Dansgaard–Oeschger events, including the Bølling event; Greenland cooling leads the corresponding onset of Antarctic warming by 208 ± 96 years. Our results demonstrate a north-to-south directionality of the abrupt climatic signal, which is propagated to the Southern Hemisphere high latitudes by oceanic rather than atmospheric processes. The similar interpolar phasing of warming and cooling transitions suggests that the transfer time of the climatic signal is independent of the AMOC background state. Our findings confirm a central role for ocean circulation in the bipolar seesaw and provide clear criteria for assessing hypotheses and model simulations of Dansgaard–Oeschger dynamics.

  16. Optofluidic manipulation of Escherichia coli in a microfluidic channel using an abruptly tapered optical fiber

    NASA Astrophysics Data System (ADS)

    Xin, Hongbao; Li, Yayi; Li, Lingshan; Xu, Rui; Li, Baojun

    2013-07-01

    We report stable optical trapping and controlled manipulation of Escherichia coli cells in a microfluidic channel using an abruptly tapered optical fiber with 980-nm wavelength laser light launched. Stability of the trapping at different optical powers (10-70 mW) was demonstrated in fluids under different flow directions and velocities. The experimental results were supported by finite-element simulations and analytic calculations.

  17. Abrupt changes in alpha-decay systematics as a manifestation of collective nuclear modes

    SciTech Connect

    Qi, C.; Liotta, R. J.; Wyss, R. A.; Andreyev, A. N.; Huyse, M.; Van Duppen, P.

    2010-06-15

    An abrupt change in alpha-decay systematics around the N=126 neutron shell closure is discussed. It is explained as a sudden hindrance of the clustering of the nucleons that eventually form the alpha particle. This is because the clustering induced by the pairing mode acting upon the four nucleons is inhibited if the configuration space does not allow a proper manifestation of the pairing collectivity.

  18. Involvement of human decidual cell-expressed tissue factor in uterine hemostasis and abruption.

    PubMed

    Lockwood, C J; Paidas, M; Murk, W K; Kayisli, U A; Gopinath, A; Huang, S J; Krikun, G; Schatz, F

    2009-11-01

    Vascular injury increases access and binding of plasma-derived factor VII to perivascular cell membrane-bound tissue factor (TF). The resulting TF/VIIa complex promotes hemostasis by cleaving pro-thrombin to thrombin leading to the fibrin clot. In human pregnancy, decidual cell-expressed TF prevents decidual hemorrhage (abruption). During placentation, trophoblasts remodel decidual spiral arteries into high conductance vessels. Shallow trophoblast invasion impedes decidual vascular conversion, producing an inadequate uteroplacental blood flow that elicits abruption-related placental ischemia. Thrombin induces several biological effects via cell surface protease activated receptors. In first trimester human DCs thrombin increases synthesis of sFlt-1, which elicits placental ischemia by impeding angiogenesis-related decidual vascular remodeling. During pregnacy, the fibrillar collagen-rich amnion and choriodecidua extracellular matrix (ECM) provides greater than additive tensile strength and structural integrity. Thrombin acts as an autocrine/paracrine mediator that degrades these ECMs by augmenting decidual cell expression of: 1) matrix metalloproteinases and 2) interleukin-8, a key mediator of abruption-associated decidual infiltration of neutrophils, which express several ECM degrading proteases. Among the cell types at the maternal fetal interface at term, TF expression is highest in decidual cells indicating that this TF meets the hemostatic demands of labor and delivery. TF expression in cultured term decidual cells is enhanced by progestin and thrombin suggesting that the maintenance of elevated circulating progesterone provides hemostatic protection and that abruption-generated thrombin acts in an autocrine/paracrine fashion on decidual cells to promote hemostasis via enhanced TF expression.

  19. Involvement of human decidual cell-expressed tissue factor in uterine hemostasis and abruption

    PubMed Central

    Lockwood, C.J.; Paidas, M.; Murk, W.K.; Kayisli, U.A.; Gopinath, A.; Krikun, G.; Huang, S.J.; Schatz, F.

    2009-01-01

    Vascular injury increases access and binding of plasma-derived factor VII to perivascular cell membrane-bound tissue factor (TF). The resulting TF/VIIa complex promotes hemostasis by cleaving pro-thrombin to thrombin leading to the fibrin clot. In human pregnancy, decidual cell-expressed TF prevents decidual hemorrhage (abruption). During placentation, trophoblasts remodel decidual spiral arteries into high conductance vessels. Shallow trophoblast invasion impedes decidual vascular conversion, producing an inadequate uteroplacental blood flow that elicits abruption-related placental ischemia. Thrombin induces several biological effects via cell surface protease activated receptors. In first trimester human DCs thrombin increases synthesis of sFlt-1, which elicits placental ischemia by impeding angiogenesis-related decidual vascular remodeling. During pregnacy, the fibrillar collagen-rich amnion and choriodecidua extracellular matrix (ECM) provides greater than additive tensile strength and structural integrity. Thrombin acts as an autocrine/paracrine mediator that degrades these ECMs by augmenting decidual cell expression of: 1) matrix metalloproteinases and 2) interleukin-8, a key mediator of abruption-associated decidual infiltration of neutrophils, which express several ECM degrading proteases. Our recent observations that: 1) among the cell types at the maternal fetal interface at term TF expression is highest in decidual cells indicates that this TF meets the hemostatic demands of labor and delivery; 2) TF expression in cultured term decidual cells is enhanced by progestin and thrombin suggest that maintenance of elevated circulating progesterone at term provides hemostatic protection, whereas abruption-generated thrombin can act in autocrine/paracrine fashion on DCs to promote hemostasis via enhanced TF expression. PMID:19720393

  20. Superfecundation and dual paternity in a twin pregnancy ending with placental abruption.

    PubMed

    Ambach, E; Parson, W; Brezinka, C

    2000-01-01

    A case of superfecundation and dual paternity in a twin pregnancy is presented. Placental abruption developed at week 33 of gestation and the two boys had to be saved by emergency cesarean section. As they shared one placenta, had almost identical weight and had the same sex, they were assumed to be monozygotic. However, a subsequent paternity suit led to the conclusion, based on DNA-analysis, that the twin brothers had been fathered by two different men. Obstetrical implications are discussed.

  1. Abrupt shutdown of the Atlantic meridional overturning circulation and rainfall patterns in Mexico

    NASA Astrophysics Data System (ADS)

    Martinez-Lopez, B.; Garcia, C. Gay

    2010-03-01

    Abrupt shutdown of the Atlantic meridional overturning circulation and rainfall patterns in Mexico. Model simulations agree that the warming and the resulting freshening of the surface waters will significantly reduce deep water formation in the Labrador Sea during the next decades. A complete collapse of the Atlantic meridional overturning circulation (AMOC) would be associated with a strong cooling of several degrees in the North Atlantic region (Winton 2003). The future response of the AMOC, however, is predictable only within a broad range due to the existence of a critical threshold in the system and the large uncertainty about both the location of this threshold on the freshwater axis and the freshwater forcing (Zickfeld et al., 2007). According to Meehl et al. (2007), the probability of an abrupt slowdown or shutdown of the AMOC triggered by greenhouse gas forcing is low, but it is considered a high-impact event (Wood et al., 2003). An abrupt change in the AMOC could occur so unexpectedly and quickly that natural systems would have difficulty adapting to them (NRC, 2002). In this work we use coupled ocean-atmosphere models to asses the response of rainfall patterns in Mexico to an abrupt shutdown of the AMOC. First, a cooling pattern, triggered by a freshwater flux perturbation in the North Atlantic, is simulated by an isopycnic ocean model coupled to an atmospheric energy balance model. Then, this anomalous surface temperature pattern is used as a surface boundary condition for a numerical experiment performed using the simplified global atmospheric circulation model PUMA (Portable University Model of the Atmosphere; Fraedrich et al., 1998), which compute the perturbed rainfall patterns in Mexico.

  2. Abrupt climate change in West Antarctica and Greenland during the last deglacial warming

    NASA Astrophysics Data System (ADS)

    Fudge, T. J.; Steig, E. J.; Brook, E.; Buizert, C.; Conway, H.; Ding, Q.; Markle, B. R.; McConnell, J. R.; Pedro, J. B.; Schoenemann, S. W.; Severinghaus, J. P.; Sigl, M.; Sowers, T. A.; Taylor, K.; Waddington, E. D.

    2013-12-01

    The WAIS Divide ice core is the first Southern Hemisphere record with precision similar to ice cores from Greenland. The annually resolved timescale and small gas-age ice-age difference allow the phasing of climate change in the two hemispheres to be compared with unprecedented precision. We focus on the three abrupt climate changes in Greenland during the deglacial transition and the corresponding changes at WAIS Divide. The onset of the Antarctic Cold Reversal (ACR) is clearly defined in the WAIS Divide record and lagged the Bolling-Allerod (BA) warming by 150×50 years. The phasing of the other two abrupt climate changes cannot be distinguished from synchronous with an uncertainty of ~200 years because the transitions from warming to cooling (or cooling to warming) are not distinct in the WAIS Divide record. The lead-lag relationships of no more than a couple centuries confirm the tight coupling between hemispheres during the deglaciation. The independent timescale of WAIS Divide confirms that meltwater Pulse 1a began near-coincident with the BA and ACR although the lack of direct synchronization between the annually dated ice-core imescales and the radiometrically dated coral timescale prevents the phasing from being known to better than a couple of centuries. A new observation from WAIS Divide is that accumulation increased ~40% between 12.0 and 11.6 ka, with the accumulation increase ending approximately coincident with the warming at the end of the Younger Dryas in Greenland. Other Antarctic ice cores lack timescales with sufficient resolution to identify such abrupt changes so it is unclear how much of Antarctica was affected by the increased accumulation rates. The inter-hemispheric relationships are often limited to a discussion of warming, but the WAIS Divide records suggests that the moisture transport may be another important constraint on the mechanisms that drive abrupt climate change.

  3. Abrupt PN junctions: Analytical solutions under equilibrium and non-equilibrium

    NASA Astrophysics Data System (ADS)

    Khorasani, Sina

    2016-08-01

    We present an explicit solution of carrier and field distributions in abrupt PN junctions under equilibrium. An accurate logarithmic numerical method is implemented and results are compared to the analytical solutions. Analysis of results shows reasonable agreement with numerical solution as well as the depletion layer approximation. We discuss extensions to the asymmetric junctions. Approximate relations for differential capacitance C-V and current-voltage I-V characteristics are also found under non-zero external bias.

  4. Precise interpolar phasing of abrupt climate change during the last ice age.

    PubMed

    2015-04-30

    The last glacial period exhibited abrupt Dansgaard-Oeschger climatic oscillations, evidence of which is preserved in a variety of Northern Hemisphere palaeoclimate archives. Ice cores show that Antarctica cooled during the warm phases of the Greenland Dansgaard-Oeschger cycle and vice versa, suggesting an interhemispheric redistribution of heat through a mechanism called the bipolar seesaw. Variations in the Atlantic meridional overturning circulation (AMOC) strength are thought to have been important, but much uncertainty remains regarding the dynamics and trigger of these abrupt events. Key information is contained in the relative phasing of hemispheric climate variations, yet the large, poorly constrained difference between gas age and ice age and the relatively low resolution of methane records from Antarctic ice cores have so far precluded methane-based synchronization at the required sub-centennial precision. Here we use a recently drilled high-accumulation Antarctic ice core to show that, on average, abrupt Greenland warming leads the corresponding Antarctic cooling onset by 218 ± 92 years (2σ) for Dansgaard-Oeschger events, including the Bølling event; Greenland cooling leads the corresponding onset of Antarctic warming by 208 ± 96 years. Our results demonstrate a north-to-south directionality of the abrupt climatic signal, which is propagated to the Southern Hemisphere high latitudes by oceanic rather than atmospheric processes. The similar interpolar phasing of warming and cooling transitions suggests that the transfer time of the climatic signal is independent of the AMOC background state. Our findings confirm a central role for ocean circulation in the bipolar seesaw and provide clear criteria for assessing hypotheses and model simulations of Dansgaard-Oeschger dynamics.

  5. Abrupt increase in east Indonesian rainfall from flooding of the Sunda Shelf ˜9500 years ago

    NASA Astrophysics Data System (ADS)

    Griffiths, Michael L.; Drysdale, Russell N.; Gagan, Michael K.; Zhao, Jian-xin; Hellstrom, John C.; Ayliffe, Linda K.; Hantoro, Wahyoe S.

    2013-08-01

    We present a precisely dated, multi-proxy stalagmite record from Liang Luar Cave, Flores (southeast Indonesia) that reveals a rapid increase in Indonesian monsoon rainfall at ˜9.5 ka. A "ramp-fitting" method for detecting statistically significant inflections in a time-series was applied to the stalagmite δ18O, Mg/Ca, and Sr/Ca profiles to quantify the precise timing and magnitude of an abrupt increase in monsoon strength over a period of ˜350 years. Previously published lake-level records from the monsoon-affected Australian interior show a sudden intensification of the Australian monsoon at ˜14 ka. However, our records indicate that monsoon intensification in Flores occured ˜4-5 kyr later. The timing of the monsoon shift in Flores is synchronous with the rapid expansion of rainforest in northeast Australia and regional freshening of the southern Makassar Strait which, under present-day conditions, is sensitive to monsoon variability. The freshening of southern Makassar was coeval with an abrupt ˜1.5 °C cooling in the upper thermocline of the Timor Sea ˜9.5 ka, indicative of reduced surface heat transport by the Indonesian Throughflow (ITF) when the Java Sea opened during postglacial sea-level rise. This suggests that the abrupt increase in monsoon rainfall on Flores was not due to a change in the ITF - because a decrease in rainfall would be expected to accompany cooler local sea surface temperatures (SSTs) - but rather by the sudden increase in ocean surface area and/or temperature in the monsoon source region as the Sunda Shelf flooded during deglaciation. We propose that it was the abrupt intensification of the monsoon through the late deglaciation that maintained the subsequent structure of the ITF following the flooding of the Sunda Shelf at ˜9.5 ka.

  6. A Fast Framework for Abrupt Change Detection Based on Binary Search Trees and Kolmogorov Statistic.

    PubMed

    Qi, Jin-Peng; Qi, Jie; Zhang, Qing

    2016-01-01

    Change-Point (CP) detection has attracted considerable attention in the fields of data mining and statistics; it is very meaningful to discuss how to quickly and efficiently detect abrupt change from large-scale bioelectric signals. Currently, most of the existing methods, like Kolmogorov-Smirnov (KS) statistic and so forth, are time-consuming, especially for large-scale datasets. In this paper, we propose a fast framework for abrupt change detection based on binary search trees (BSTs) and a modified KS statistic, named BSTKS (binary search trees and Kolmogorov statistic). In this method, first, two binary search trees, termed as BSTcA and BSTcD, are constructed by multilevel Haar Wavelet Transform (HWT); second, three search criteria are introduced in terms of the statistic and variance fluctuations in the diagnosed time series; last, an optimal search path is detected from the root to leaf nodes of two BSTs. The studies on both the synthetic time series samples and the real electroencephalograph (EEG) recordings indicate that the proposed BSTKS can detect abrupt change more quickly and efficiently than KS, t-statistic (t), and Singular-Spectrum Analyses (SSA) methods, with the shortest computation time, the highest hit rate, the smallest error, and the highest accuracy out of four methods. This study suggests that the proposed BSTKS is very helpful for useful information inspection on all kinds of bioelectric time series signals. PMID:27413364

  7. Placental abruption and perinatal mortality with preterm delivery as a mediator: disentangling direct and indirect effects.

    PubMed

    Ananth, Cande V; VanderWeele, Tyler J

    2011-07-01

    The authors use recent methodology in causal inference to disentangle the direct and indirect effects that operate through a mediator in an exposure-response association paradigm. They demonstrate how total effects can be partitioned into direct and indirect effects even when the exposure and mediator interact. The impact of bias due to unmeasured confounding on the exposure-response association is assessed through a series of sensitivity analyses. These methods are applied to a problem in perinatal epidemiology to examine the extent to which the effect of abruption on perinatal mortality is mediated through preterm delivery. Data on over 26 million US singleton births (1995-2002) were utilized. Risks of mortality among abruption and nonabruption births were 102.7 and 6.2 per 1,000 births, respectively. Risk ratios of the natural direct and indirect (preterm delivery-mediated) effects of abruption on mortality were 10.18 (95% confidence interval: 9.80, 10.58) and 1.35 (95% confidence interval: 1.33, 1.38), respectively. The proportion of increased mortality risk mediated through preterm delivery was 28.1%, with even higher proportions associated with deliveries at earlier gestational ages. Sensitivity analyses underscore that the qualitative conclusions of some mediated effects and substantial direct effects are reasonably robust to unmeasured confounding of a fairly considerable magnitude.

  8. The grain size gap and abrupt gravel-sand transitions in rivers due to suspension fallout

    NASA Astrophysics Data System (ADS)

    Lamb, Michael P.; Venditti, Jeremy G.

    2016-04-01

    Median grain sizes on riverbeds range from boulders in uplands to silt in lowlands; however, rivers with ~1-5 mm diameter bed sediment are rare. This grain size gap also marks an abrupt transition between gravel- and sand-bedded reaches that is unlike any other part of the fluvial network. Abrupt gravel-sand transitions have been attributed to rapid breakdown or rapid transport of fine gravel, or a bimodal sediment supply, but supporting evidence is lacking. Here we demonstrate that rivers dramatically lose the ability to transport sand as wash load where bed shear velocity drops below ~0.1 m/s, forcing an abrupt transition in bed-material grain size. Using thresholds for wash load and initial motion, we show that the gap emerges only for median bed-material grain sizes of ~1-5 mm due to Reynolds number dependencies in suspension transport. The grain size gap, therefore, is sensitive to material properties and gravity, with coarser gaps predicted on Mars and Titan.

  9. Consistent simulations of multiple proxy responses to an abrupt climate change event

    PubMed Central

    LeGrande, A. N.; Schmidt, G. A.; Shindell, D. T.; Field, C. V.; Miller, R. L.; Koch, D. M.; Faluvegi, G.; Hoffmann, G.

    2006-01-01

    Isotope, aerosol, and methane records document an abrupt cooling event across the Northern Hemisphere at 8.2 kiloyears before present (kyr), while separate geologic lines of evidence document the catastrophic drainage of the glacial Lakes Agassiz and Ojibway into the Hudson Bay at approximately the same time. This melt water pulse may have been the catalyst for a decrease in North Atlantic Deep Water formation and subsequent cooling around the Northern Hemisphere. However, lack of direct evidence for ocean cooling has lead to speculation that this abrupt event was purely local to Greenland and called into question this proposed mechanism. We simulate the response to this melt water pulse using a coupled general circulation model that explicitly tracks water isotopes and with atmosphere-only experiments that calculate changes in atmospheric aerosol deposition (specifically 10Be and dust) and wetland methane emissions. The simulations produce a short period of significantly diminished North Atlantic Deep Water and are able to quantitatively match paleoclimate observations, including the lack of isotopic signal in the North Atlantic. This direct comparison with multiple proxy records provides compelling evidence that changes in ocean circulation played a major role in this abrupt climate change event. PMID:16415159

  10. A Fast Framework for Abrupt Change Detection Based on Binary Search Trees and Kolmogorov Statistic

    PubMed Central

    Qi, Jin-Peng; Qi, Jie; Zhang, Qing

    2016-01-01

    Change-Point (CP) detection has attracted considerable attention in the fields of data mining and statistics; it is very meaningful to discuss how to quickly and efficiently detect abrupt change from large-scale bioelectric signals. Currently, most of the existing methods, like Kolmogorov-Smirnov (KS) statistic and so forth, are time-consuming, especially for large-scale datasets. In this paper, we propose a fast framework for abrupt change detection based on binary search trees (BSTs) and a modified KS statistic, named BSTKS (binary search trees and Kolmogorov statistic). In this method, first, two binary search trees, termed as BSTcA and BSTcD, are constructed by multilevel Haar Wavelet Transform (HWT); second, three search criteria are introduced in terms of the statistic and variance fluctuations in the diagnosed time series; last, an optimal search path is detected from the root to leaf nodes of two BSTs. The studies on both the synthetic time series samples and the real electroencephalograph (EEG) recordings indicate that the proposed BSTKS can detect abrupt change more quickly and efficiently than KS, t-statistic (t), and Singular-Spectrum Analyses (SSA) methods, with the shortest computation time, the highest hit rate, the smallest error, and the highest accuracy out of four methods. This study suggests that the proposed BSTKS is very helpful for useful information inspection on all kinds of bioelectric time series signals. PMID:27413364

  11. A Fast Framework for Abrupt Change Detection Based on Binary Search Trees and Kolmogorov Statistic.

    PubMed

    Qi, Jin-Peng; Qi, Jie; Zhang, Qing

    2016-01-01

    Change-Point (CP) detection has attracted considerable attention in the fields of data mining and statistics; it is very meaningful to discuss how to quickly and efficiently detect abrupt change from large-scale bioelectric signals. Currently, most of the existing methods, like Kolmogorov-Smirnov (KS) statistic and so forth, are time-consuming, especially for large-scale datasets. In this paper, we propose a fast framework for abrupt change detection based on binary search trees (BSTs) and a modified KS statistic, named BSTKS (binary search trees and Kolmogorov statistic). In this method, first, two binary search trees, termed as BSTcA and BSTcD, are constructed by multilevel Haar Wavelet Transform (HWT); second, three search criteria are introduced in terms of the statistic and variance fluctuations in the diagnosed time series; last, an optimal search path is detected from the root to leaf nodes of two BSTs. The studies on both the synthetic time series samples and the real electroencephalograph (EEG) recordings indicate that the proposed BSTKS can detect abrupt change more quickly and efficiently than KS, t-statistic (t), and Singular-Spectrum Analyses (SSA) methods, with the shortest computation time, the highest hit rate, the smallest error, and the highest accuracy out of four methods. This study suggests that the proposed BSTKS is very helpful for useful information inspection on all kinds of bioelectric time series signals.

  12. Abrupt shifts in Horn of Africa hydroclimate and the influence of the Indian Ocean (Invited)

    NASA Astrophysics Data System (ADS)

    Tierney, J. E.; deMenocal, P. B.

    2013-12-01

    The timing and abruptness with which Northeast Africa transitioned into and out of the Early Holocene African Humid Period is a subject of ongoing debate, with direct consequences for our understanding of climate stability and paleoenvironments. Here we present a new proxy record of regional hydroclimate, based on the hydrogen isotopic composition of leaf waxes, from a marine core in the Gulf of Aden that documents rapid, century-scale transitions into and out of the African Humid Period across the Horn of Africa. The Gulf of Aden record also documents large drying events during the last deglacial, synchronous with Heinrich Event 1 and the Younger Dryas. Similar and generally synchronous abrupt transitions at other East African sites suggest that rapid shifts in hydroclimate are regionally coherent. In addition, the termination of the African Humid Period in East Africa is synchronous with the termination along the western Saharan margin. A probabilistic analysis of the abruptness of the transitions in East Africa suggests that they likely occurred within centuries, underscoring the sensitivity of northeast African hydroclimate to external forcings. We speculate that the non-linear behavior of hydroclimate in the Horn of Africa is related to convection thresholds in the western Indian Ocean, and test this hypothesis with preliminary SST proxy data.

  13. Consistent simulations of multiple proxy responses to an abrupt climate change event.

    PubMed

    LeGrande, A N; Schmidt, G A; Shindell, D T; Field, C V; Miller, R L; Koch, D M; Faluvegi, G; Hoffmann, G

    2006-01-24

    Isotope, aerosol, and methane records document an abrupt cooling event across the Northern Hemisphere at 8.2 kiloyears before present (kyr), while separate geologic lines of evidence document the catastrophic drainage of the glacial Lakes Agassiz and Ojibway into the Hudson Bay at approximately the same time. This melt water pulse may have been the catalyst for a decrease in North Atlantic Deep Water formation and subsequent cooling around the Northern Hemisphere. However, lack of direct evidence for ocean cooling has lead to speculation that this abrupt event was purely local to Greenland and called into question this proposed mechanism. We simulate the response to this melt water pulse using a coupled general circulation model that explicitly tracks water isotopes and with atmosphere-only experiments that calculate changes in atmospheric aerosol deposition (specifically (10)Be and dust) and wetland methane emissions. The simulations produce a short period of significantly diminished North Atlantic Deep Water and are able to quantitatively match paleoclimate observations, including the lack of isotopic signal in the North Atlantic. This direct comparison with multiple proxy records provides compelling evidence that changes in ocean circulation played a major role in this abrupt climate change event. PMID:16415159

  14. Abrupt change of Antarctic moisture origin at the end of Termination II

    PubMed Central

    Masson-Delmotte, V.; Stenni, B.; Blunier, T.; Cattani, O.; Chappellaz, J.; Cheng, H.; Dreyfus, G.; Edwards, R. L.; Falourd, S.; Govin, A.; Kawamura, K.; Johnsen, S. J.; Jouzel, J.; Landais, A.; Lemieux-Dudon, B.; Lourantou, A.; Marshall, G.; Minster, B.; Mudelsee, M.; Pol, K.; Röthlisberger, R.; Selmo, E.; Waelbroeck, C.

    2010-01-01

    The deuterium excess of polar ice cores documents past changes in evaporation conditions and moisture origin. New data obtained from the European Project for Ice Coring in Antarctica Dome C East Antarctic ice core provide new insights on the sequence of events involved in Termination II, the transition between the penultimate glacial and interglacial periods. This termination is marked by a north–south seesaw behavior, with first a slow methane concentration rise associated with a strong Antarctic temperature warming and a slow deuterium excess rise. This first step is followed by an abrupt north Atlantic warming, an abrupt resumption of the East Asian summer monsoon, a sharp methane rise, and a CO2 overshoot, which coincide within dating uncertainties with the end of Antarctic optimum. Here, we show that this second phase is marked by a very sharp Dome C centennial deuterium excess rise, revealing abrupt reorganization of atmospheric circulation in the southern Indian Ocean sector. PMID:20566887

  15. A genome-wide association study of variations in maternal cardiometabolic genes and risk of placental abruption

    PubMed Central

    Moore, Amy; Enquobahrie, Daniel A; Sanchez, Sixto E; Ananth, Cande V; Pacora, Percy N; Williams, Michelle A

    2012-01-01

    Accumulating evidence suggests that placental abruption has a complex multifactorial pathogenesis that involves cardiovascular risk and metabolic dysfunction. However, comprehensive assessment of variations in genes involved in cardiometabolic traits associated with the risk of placental abruption is lacking. We conducted a case-control study investigating associations of variations in maternal cardiometabolic genes (characterized using 217,697 SNPs on the Illumina Cardio-Metabo Chip) with risk of placental abruption. A total of 253 abruption cases and 258 controls were selected from among participants enrolled in the Peruvian Abruptio Placentae Epidemiology Study in Lima, Peru. In the genome-wide association analyses, top hits did not surpass genome-wide significance. However, we observed suggestive associations of placental abruption with several SNPs, including SNPs in SMAD2 (P-value=1.88e-6), MIR17HG (P-value=7.8e-6], and DGKB (P-value=8.35e-6] loci. In candidate gene analyses, we observed associations of variations in a priori selected genes involved in coagulation, rennin-angiotensin, angiogenesis, inflammation, and B-vitamin metabolism with the risk of abruption. Our study suggests that variations in maternal cardiovascular and metabolic genes may be associated with risk of placental abruption. Future studies with large sample sizes are warranted. PMID:23205182

  16. Regional Abrupt Climate Change in the U.S.: Comparing the Colorado and Columbia River Basins

    NASA Astrophysics Data System (ADS)

    Lund, D.

    2001-12-01

    Paleoclimatic evidence and historical experience indicate the earth's climate system is capable of switching rapidly from one quasi-stable state to another. Current global assessments of anthropogenic climate change, however, do not fully account for such abrupt shifts, and instead generally assume the earth's climate will gradually warm over the next several centuries. Integrated assessments of abrupt climate change exist, but on a regional level. Here we discuss two examples where abrupt climate change information was applied to the management of natural resources, including water in the Colorado Basin and salmon in the Columbia Basin. Tree-ring data imply that a massive 20-yr drought occurred in the Colorado Basin during the late sixteenth century. The Severe-Sustained Drought assessment (SSD) evaluated the socioeconomic impacts of this historically-unprecedented drought in the context of modern water allocation policy in the Colorado Basin. Based on semi-structured, open-ended interviews with assessment participants and regional stakeholders, the SSD clarified positions of competing water interests and expanded awareness of potential drought impacts, but did not modify Colorado River water management or policies. Assessment design characteristics had limited influence on effectiveness; the timing of publication and political and legal factors constraining alternative policy options for water distribution were more influential determinants. Absent a crisis, there are few incentives for water managers to implement SSD policy recommendations. The lack of a basin wide commission and long-term climate assessment group in the Colorado Basin appear to limit stakeholder ability to utilize technical information related to abrupt climate change. In the Columbia River Basin, the crisis of declining salmon stocks motivated the consideration of alternative policies which recognize the role of unpredictable and abrupt decadal shifts in oceanic productivity. Although actual

  17. Intramammary infections and milk leakage following gradual or abrupt cessation of milking.

    PubMed

    Gott, P N; Rajala-Schultz, P J; Schuenemann, G M; Proudfoot, K L; Hogan, J S

    2016-05-01

    The objective of this study was to evaluate the effect of milking cessation method (abrupt or gradual) and daily milk yield before dry-off on milk leakage following dry-off and intramammary infections (IMI) at calving. Data from 1,086 quarters of 285 cows from 5 Ohio dairy herds were analyzed. All cows that were due to be dried off within a week were assigned to the same study group to facilitate management. Abrupt-cessation cows kept the farm's regular milking schedule through dry-off, and gradual-cessation cows were milked once daily for the final week of lactation. Aseptic technique was used to collect quarter foremilk samples at the time of enrollment (7 to 14 d before expected dry-off), the final milking before dry-off (D-O), and within 7 d of calving. Cows in the gradual-cessation group were observed for milk leakage during the period of once-daily milking. In the only herd that did not use internal teat sealants at dry-off, milk leakage after dry-off was recorded in both abrupt and gradual groups. Gradual cessation decreased milk production by 33.4% during the final week of lactation, causing milk yield at D-O to be lower for these cows compared with abrupt-cessation cows (13.2 vs. 19.8kg/d, respectively). Logistic regression models were used to model the probability of a quarter being infected at calving with any pathogen, accounting for clustering of quarters within cows and cows within herds. The final model investigating the probability of IMI at calving was stratified by parity of cows at the time of dry-off (primiparous and multiparous). Among quarters of cows that ended their first lactation, abrupt cessation of milking before dry-off and milk leakage after dry-off were associated with an increased risk of IMI at calving. Among quarters of multiparous cows, on the other hand, gradual cessation of milking before dry-off, presence of IMI at D-O, and thrice-daily milking during lactation increased the odds of IMI at calving. These results indicate that

  18. Diagnostic Performance of Ultrasonography for Detection of Abruption and Its Clinical Correlation and Maternal and Foetal Outcome

    PubMed Central

    Vaswani, Babita Prakash; Patange, R.P.; Laddad, Manisha Manish; Bhosale, Rajashree Babasaheb

    2016-01-01

    Introduction Placental abruption complicates about 1% of singleton pregnancies and is an important cause of perinatal mortality and morbidity. Though sensitivity and reliability of ultrasound are poor for detecting or excluding placental abruption, because of the advances in ultrasound resolution, imaging and interpretation, sensitivity of ultrasound is better than what was reported previously. Aim To determine the diagnostic performance of Ultrasonography (USG) for the detection of placental abruption and whether sonographic results correlate with maternal and foetal management and outcome. Materials and Methods Thirty patients with clinical diagnosis of placental abruption were studied in the Obstetrics and Gynaecology Department of Krishna Institute of Medical Sciences, over a period of 6 months. These patients underwent ultrasonography for confirmation. Obstetric and neonatal outcome and sonographic results were compared and reviewed. Sonographic sensitivity and specificity and positive and negative predictive values were calculated. Results Incidence of abruption in present study was 1.56% (28 patients out of 1786 total deliveries). Sensitivity of ultrasonography in the diagnosis of abruption was 57% (CI 37.15%-75.57%) while its specificity was 100% (CI 15.81%-100%) with a positive predictive value of 100% (CI 79.42%-100%) and a 14% (CI 1.78% - 42.83%) negative predictive value. An 87.5% of patients(14 out of 16) with a positive USG finding of abruption had Intrauterine foetal Death (IUD)/still birth while 91.6% of patients (11 out of 12) with negative USG findings of abruption gave birth to babies who required NICU admission. Conclusion Sonography is not sensitive for the detection of placental abruption but it is highly specific. Positive sonographic findings are associated with increased maternal morbidity, require more aggressive obstetric management and it is associated with worse perinatal outcome. In case of a negative USG finding, but a strong clinical

  19. Dietary restriction with and without caloric restriction for healthy aging

    PubMed Central

    Lee, Changhan; Longo, Valter

    2016-01-01

    Caloric restriction is the most effective and reproducible dietary intervention known to regulate aging and increase the healthy lifespan in various model organisms, ranging from the unicellular yeast to worms, flies, rodents, and primates. However, caloric restriction, which in most cases entails a 20–40% reduction of food consumption relative to normal intake, is a severe intervention that results in both beneficial and detrimental effects. Specific types of chronic, intermittent, or periodic dietary restrictions without chronic caloric restriction have instead the potential to provide a significant healthspan increase while minimizing adverse effects. Improved periodic or targeted dietary restriction regimens that uncouple the challenge of food deprivation from the beneficial effects will allow a safe intervention feasible for a major portion of the population. Here we focus on healthspan interventions that are not chronic or do not require calorie restriction. PMID:26918181

  20. Dietary restriction with and without caloric restriction for healthy aging.

    PubMed

    Lee, Changhan; Longo, Valter

    2016-01-01

    Caloric restriction is the most effective and reproducible dietary intervention known to regulate aging and increase the healthy lifespan in various model organisms, ranging from the unicellular yeast to worms, flies, rodents, and primates. However, caloric restriction, which in most cases entails a 20-40% reduction of food consumption relative to normal intake, is a severe intervention that results in both beneficial and detrimental effects. Specific types of chronic, intermittent, or periodic dietary restrictions without chronic caloric restriction have instead the potential to provide a significant healthspan increase while minimizing adverse effects. Improved periodic or targeted dietary restriction regimens that uncouple the challenge of food deprivation from the beneficial effects will allow a safe intervention feasible for a major portion of the population. Here we focus on healthspan interventions that are not chronic or do not require calorie restriction. PMID:26918181

  1. Restrictive vs. non-restrictive composition: a magnetoencephalography study

    PubMed Central

    Leffel, Timothy; Lauter, Miriam; Westerlund, Masha; Pylkkänen, Liina

    2014-01-01

    Recent research on the brain mechanisms underlying language processing has implicated the left anterior temporal lobe (LATL) as a central region for the composition of simple phrases. Because these studies typically present their critical stimuli without contextual information, the sensitivity of LATL responses to contextual factors is unknown. In this magnetoencephalography (MEG) study, we employed a simple question-answer paradigm to manipulate whether a prenominal adjective or determiner is interpreted restrictively, i.e., as limiting the set of entities under discussion. Our results show that the LATL is sensitive to restriction, with restrictive composition eliciting higher responses than non-restrictive composition. However, this effect was only observed when the restricting element was a determiner, adjectival stimuli showing the opposite pattern, which we hypothesise to be driven by the special pragmatic properties of non-restrictive adjectives. Overall, our results demonstrate a robust sensitivity of the LATL to high level contextual and potentially also pragmatic factors. PMID:25379512

  2. Prenatal diagnosis of a placental infarction hematoma associated with fetal growth restriction, preeclampsia and fetal death: clinicopathological correlation.

    PubMed

    Aurioles-Garibay, Alma; Hernandez-Andrade, Edgar; Romero, Roberto; Qureshi, Faisal; Ahn, Hyunyoung; Jacques, Suzanne M; Garcia, Maynor; Yeo, Lami; Hassan, Sonia S

    2014-01-01

    The lesion termed 'placental infarction hematoma' is associated with fetal death and adverse perinatal outcome. Such a lesion has been associated with a high risk of fetal death and abruption placentae. The fetal and placental hemodynamic changes associated with placental infarction hematoma have not been reported. This paper describes a case of early and severe growth restriction with preeclampsia, and progressive deterioration of the fetal and placental Doppler parameters in the presence of a placental infarction hematoma.

  3. Abrupt climate change at the end of the last glacial period inferred from trapped air in polar Ice

    PubMed

    Severinghaus; Brook

    1999-10-29

    The last glacial period was terminated by an abrupt warming event in the North Atlantic approximately 15,000 years before the present, and warming events of similar age have been reported from low latitudes. Understanding the mechanism of this termination requires that the precise relative timing of abrupt climate warming in the tropics versus the North Atlantic be known. Nitrogen and argon isotopes in trapped air in Greenland ice show that the Greenland Summit warmed 9 +/- 3 degrees C over a period of several decades, beginning 14,672 years ago. Atmospheric methane concentrations rose abruptly over a approximately 50-year period and began their increase 20 to 30 years after the onset of the abrupt Greenland warming. These data suggest that tropical climate became warmer or wetter (or both) approximately 20 to 80 years after the onset of Greenland warming, supporting a North Atlantic rather than a tropical trigger for the climate event.

  4. Restricting retrotransposons: a review.

    PubMed

    Goodier, John L

    2016-01-01

    Retrotransposons have generated about 40 % of the human genome. This review examines the strategies the cell has evolved to coexist with these genomic "parasites", focussing on the non-long terminal repeat retrotransposons of humans and mice. Some of the restriction factors for retrotransposition, including the APOBECs, MOV10, RNASEL, SAMHD1, TREX1, and ZAP, also limit replication of retroviruses, including HIV, and are part of the intrinsic immune system of the cell. Many of these proteins act in the cytoplasm to degrade retroelement RNA or inhibit its translation. Some factors act in the nucleus and involve DNA repair enzymes or epigenetic processes of DNA methylation and histone modification. RISC and piRNA pathway proteins protect the germline. Retrotransposon control is relaxed in some cell types, such as neurons in the brain, stem cells, and in certain types of disease and cancer, with implications for human health and disease. This review also considers potential pitfalls in interpreting retrotransposon-related data, as well as issues to consider for future research. PMID:27525044

  5. Antiretroviral restriction factors in mice.

    PubMed

    Nair, Smita; Rein, Alan

    2014-11-26

    One of the most exciting areas in contemporary retrovirus research is the discovery of "restriction factors". These are cellular proteins that act after virus entry to inhibit infection by or replication of retroviruses (and other viruses and intracellular pathogens). We briefly discuss here three antiretroviral restriction factors in mice: Fv1, APOBEC3, and tetherin, touching on both biological and molecular aspects of these restriction systems.

  6. Testing massive Arctic sea ice export as a trigger for abrupt climate change

    NASA Astrophysics Data System (ADS)

    Coletti, Anthony; Condron, Alan; Bradley, Raymond

    2014-05-01

    The discharge of freshwater from glacial lakes to the North Atlantic is repeatedly cited as the main trigger for abrupt centennial to millennial length climate change during the last deglaciation. Broecker et al., (1989) was a proponent of this idea suggesting that abrupt re-routing of pro-glacial lake freshwater to the North Atlantic through the St. Lawrence Valley weakened the strength of the AMOC. Yet, evidence for this is lacking, freshwater estimates in these lakes are relatively small and flood durations are rather short (<5 years), suggesting that floods may not have been the only mechanism driving these climate shifts. Using sophisticated ocean modeling, it has been shown that the release of freshwater originating from the Arctic is more effective at weakening the AMOC compared to freshwater released further south. Here we investigate whether the break-up and mobilization of thick Arctic sea-ice would have supplied enough freshwater to the Nordic Seas to sufficiently cause dampening of the AMOC and hinder NADW formation in the sub-polar North Atlantic. We use numerical climate models to assess 1) the maximum thickness of sea ice that can be formed during glacial periods and the volume of freshwater in the ice, 2) the mechanism which caused the collapse and mobilization of arctic sea-ice into the North Atlantic and 3) the impact of melting sea-ice on global ocean circulation. This hypothesis focuses on the potential impacts of sea-ice as a forcing mechanism for abrupt climate change events on geologic time scales.

  7. West African monsoon dynamics inferred from abrupt fluctuations of Lake Mega-Chad

    PubMed Central

    Armitage, Simon J.; Bristow, Charlie S.; Drake, Nick A.

    2015-01-01

    From the deglacial period to the mid-Holocene, North Africa was characterized by much wetter conditions than today. The broad timing of this period, termed the African Humid Period, is well known. However, the rapidity of the onset and termination of the African Humid Period are contested, with strong evidence for both abrupt and gradual change. We use optically stimulated luminescence dating of dunes, shorelines, and fluviolacustrine deposits to reconstruct the fluctuations of Lake Mega-Chad, which was the largest pluvial lake in Africa. Humid conditions first occur at ∼15 ka, and by 11.5 ka, Lake Mega-Chad had reached a highstand, which persisted until 5.0 ka. Lake levels fell rapidly at ∼5 ka, indicating abrupt aridification across the entire Lake Mega-Chad Basin. This record provides strong terrestrial evidence that the African Humid Period ended abruptly, supporting the hypothesis that the African monsoon responds to insolation forcing in a markedly nonlinear manner. In addition, Lake Mega-Chad exerts strong control on global biogeochemical cycles because the northern (Bodélé) basin is currently the world’s greatest single dust source and possibly an important source of limiting nutrients for both the Amazon Basin and equatorial Atlantic. However, we demonstrate that the final desiccation of the Bodélé Basin occurred around 1 ka. Consequently, the present-day mode and scale of dust production from the Bodélé Basin cannot have occurred before 1 ka, suggesting that its role in fertilizing marine and terrestrial ecosystems is either overstated or geologically recent. PMID:26124133

  8. West African monsoon dynamics inferred from abrupt fluctuations of Lake Mega-Chad.

    PubMed

    Armitage, Simon J; Bristow, Charlie S; Drake, Nick A

    2015-07-14

    From the deglacial period to the mid-Holocene, North Africa was characterized by much wetter conditions than today. The broad timing of this period, termed the African Humid Period, is well known. However, the rapidity of the onset and termination of the African Humid Period are contested, with strong evidence for both abrupt and gradual change. We use optically stimulated luminescence dating of dunes, shorelines, and fluviolacustrine deposits to reconstruct the fluctuations of Lake Mega-Chad, which was the largest pluvial lake in Africa. Humid conditions first occur at ∼ 15 ka, and by 11.5 ka, Lake Mega-Chad had reached a highstand, which persisted until 5.0 ka. Lake levels fell rapidly at ∼ 5 ka, indicating abrupt aridification across the entire Lake Mega-Chad Basin. This record provides strong terrestrial evidence that the African Humid Period ended abruptly, supporting the hypothesis that the African monsoon responds to insolation forcing in a markedly nonlinear manner. In addition, Lake Mega-Chad exerts strong control on global biogeochemical cycles because the northern (Bodélé) basin is currently the world's greatest single dust source and possibly an important source of limiting nutrients for both the Amazon Basin and equatorial Atlantic. However, we demonstrate that the final desiccation of the Bodélé Basin occurred around 1 ka. Consequently, the present-day mode and scale of dust production from the Bodélé Basin cannot have occurred before 1 ka, suggesting that its role in fertilizing marine and terrestrial ecosystems is either overstated or geologically recent.

  9. Influence of external forcings on abrupt millennial-scale climate changes: a statistical modelling study

    NASA Astrophysics Data System (ADS)

    Mitsui, Takahito; Crucifix, Michel

    2016-07-01

    The last glacial period was punctuated by a series of abrupt climate shifts, the so-called Dansgaard-Oeschger (DO) events. The frequency of DO events varied in time, supposedly because of changes in background climate conditions. Here, the influence of external forcings on DO events is investigated with statistical modelling. We assume two types of simple stochastic dynamical systems models (double-well potential-type and oscillator-type), forced by the northern hemisphere summer insolation change and/or the global ice volume change. The model parameters are estimated by using the maximum likelihood method with the NGRIP Ca^{2+} record. The stochastic oscillator model with at least the ice volume forcing reproduces well the sample autocorrelation function of the record and the frequency changes of warming transitions in the last glacial period across MISs 2, 3, and 4. The model performance is improved with the additional insolation forcing. The BIC scores also suggest that the ice volume forcing is relatively more important than the insolation forcing, though the strength of evidence depends on the model assumption. Finally, we simulate the average number of warming transitions in the past four glacial periods, assuming the model can be extended beyond the last glacial, and compare the result with an Iberian margin sea-surface temperature (SST) record (Martrat et al. in Science 317(5837): 502-507, 2007). The simulation result supports the previous observation that abrupt millennial-scale climate changes in the penultimate glacial (MIS 6) are less frequent than in the last glacial (MISs 2-4). On the other hand, it suggests that the number of abrupt millennial-scale climate changes in older glacial periods (MISs 6, 8, and 10) might be larger than inferred from the SST record.

  10. The role of stochastic noise in the abrupt climatic transitions of the pleistocene

    SciTech Connect

    Matteucci, G.

    1991-01-01

    Analyses of marine [delta][sup 18]O records suggest that the variations of the Earth's orbital parameters have induced and provided the timing of the Pleistocene climatic oscillations. This dissertation analyses some statistical properties of the Pleistocene climate by estimating the Probability Density Function (PDF) of the [delta][sup 18]O record. The results allow to define statistically what were the [open quotes]typical conditions[close quotes] (in a probabilistic sense) of the Quaternary, to identify the modes of the PDF as the mean glacial and interglacial climatic states, and to clarify the meaning and the abruptness of the climatic transitions. A zero-dimensional Energy Balance Model is developed. The nonlinearity of the ice albedo-temperature feedback leads to multiple steady-state equilibria. The role of stochastic perturbations and their interaction with the orbital forcing in producing the periodic and abrupt climatic transitions of the late Pleistocene are illustrated. A stochastic sensitivity analysis is used to clarify the results, especially the selective amplification of the orbitally-induced 100 kyr cycle, and the predictability of the system on the time scales of the orbital cycles. From the analysis of GCM simulations and observational zonally- averaged data a one-dimensional EBM is then developed. The strong nonlinearity of this model and the occurrence of multiple equilibria is caused by the presence of the Thin Ice Cap Instability. A discussion of the features that stochastic perturbations would introduce, follows. Finally a GCM sensitivity study to atmospheric CO[sub 2] shows how the effects of varying CO[sub 2] concentrations can be included in simple EBMs. The role that stochastic perturbations, orbital forcing, and the known past concentrations of atmospheric CO[sub 2] have played in producing the abrupt climatic transitions of the late Pleistocene is discussed.

  11. Bio-physical coupling in the formation of zooplankton and fish aggregations over abrupt topographies

    NASA Astrophysics Data System (ADS)

    Genin, Amatzia

    2004-09-01

    Aggregations of zooplankton, micronekton and fish are frequently observed above seamounts, canyons and shelf breaks. The aggregations are produced by five different mechanisms, all driven by ocean currents. Upwelling is frequently generated when ambient currents impinge on abrupt topographies. Nevertheless, upwelling enhances local production of zooplankton and fish only over large topographies such as shelf breaks, where the residence time of the upwelled water is sufficiently long to allow enrichment in primary production to propagate up the food web and augment the growth of resident animals. Daily accumulations occur over topographies at shallow and intermediate depths when the topography blocks the morning descent of migrating zooplankton. This mechanism is common over seamounts. Two other mechanisms are driven by behavioral response to vertical currents when zooplankton swims vertically in order to maintain depth: accumulations by depth retention against upwelling are common at depths to which migrating zooplankton descend during the day, while depth retention against downwelling seems to operate only in the upper water column (e.g., along topographically generated fronts). The fifth mechanism is driven by the amplification of currents over abrupt topographies. Strong currents enhance population growth of resident animals by augmenting fluxes of suspended food. A feed-rest hypothesis is proposed to explain how site-attached planktivorous fish can benefit from strong currents at sites with ample quiescence shelters in which the fish rest during non-feeding intervals. Four of the above mechanisms generate "trophic focusing", a process by which prey from immense volumes of flowing water is accumulated (or trapped) in a relatively small confined area. The ensuing subsidy of prey propagates up the food web, supporting aggregations of higher predators, such as fish, marine mammals and fishermen. Abrupt topographies can have an important role in determining trophic

  12. ON THE PROBABLE EXISTENCE OF AN ABRUPT MAGNETIZATION IN THE UPPER CHROMOSPHERE OF THE QUIET SUN

    SciTech Connect

    Stepan, JirI; Trujillo Bueno, Javier E-mail: jtb@iac.es

    2010-03-10

    We report on a detailed radiative transfer modeling of the observed scattering polarization in the H{alpha} line, which allows us to infer quantitative information on the magnetization of the quiet solar chromosphere. Our analysis suggests the presence of a magnetic complexity zone with a mean field strength (B) > 30 G lying just below the sudden transition region to the coronal temperatures. The chromospheric plasma directly underneath is very weakly magnetized, with (B) {approx} 1 G. The possible existence of this abrupt change in the degree of magnetization of the upper chromosphere of the quiet Sun might have large significance for our understanding of chromospheric (and, therefore, coronal) heating.

  13. On the calculation of turbulent heat and mass transport downstream from an abrupt pipe expansion

    NASA Technical Reports Server (NTRS)

    Amano, R. S.

    1982-01-01

    A numerical study is reported of heat/mass transfer in the separated flow region created by an abrupt pipe expansion. Computations have employed a hybrid method of central and upwind finite differencing to solve the full Navier-Stokes equations with turbulent model (k approximately equal to epsilon). The study has given its main attention to the simulation of the region in the immediate vicinity of the wall, by formulating near-wall model for the evaluation of the mean generation and destruction rate of the epsilon equation. The computed results were compared with the experimental data and they showed generally encouraging agreement with the measurements.

  14. Case of neuroleptic malignant-like syndrome precipitated by abrupt fava bean discontinuance.

    PubMed

    Ladha, Shafeeq S; Walker, Russell; Shill, Holly A

    2005-05-01

    Neuroleptic malignant-like syndrome (NMLS) is well described in the treatment of Parkinson's disease. The syndrome is characterized by fever, rigidity, autonomic instability, elevated creatine phosphokinase levels, and altered level of consciousness, which is usually precipitated by levodopa withdrawal. In recent years, patients have used fava beans to treat Parkinson's symptoms, because the beans contain appreciable amounts of levodopa and have been thought to be a safe adjunctive therapy. We describe a case of NMLS, which was precipitated by the abrupt cessation of fava bean ingestion.

  15. Beam losses due to abrupt crab cavity failures in the LHC

    SciTech Connect

    Baer, T.; Barranco, J.; Calaga, R.; Tomas, R.; Wenninger, B.; Yee, B.; Zimmermann, F.

    2011-03-28

    A major concern for the implementation of crab crossing in a future High-Luminosity LHC (HL-LHC) is machine protection in an event of a fast crab-cavity failure. Certain types of abrupt crab-cavity amplitude and phase changes are simulated to characterize the effect of failures on the beam and the resulting particle-loss signatures. The time-dependent beam loss distributions around the ring and particle trajectories obtained from the simulations allow for a first assessment of the resulting beam impact on LHC collimators and on sensitive components around the ring. Results for the nominal LHC lattice is presented.

  16. Abrupt variations of Indian and East Asian summer monsoons during the last deglacial stadial and interstadial

    NASA Astrophysics Data System (ADS)

    Hong, Bing; Hong, Yetang; Uchida, Masao; Shibata, Yasuyuki; Cai, Cheng; Peng, Haijun; Zhu, Yongxuan; Wang, Yu; Yuan, Linggui

    2014-08-01

    The phase relationship between the Indian summer monsoon (ISM) and the East Asian summer monsoon (EASM) during the last deglaciation remains controversial. Here, we reconstruct a 15,000-year plant cellulose δ13C proxy record for the ISM from the Yuexi peat bog in southwestern China. The record shows that the ISM abruptly decreases during the Younger Dryas (YD) stadial and abruptly increases during the Bølling-Allerød (BA) interstadial. A comparison of the Yuexi record with other related proxy climate records reveals two types of phenomena. First, the strengths of the two Asian monsoons are inversely related during the YD stadial, i.e., the ISM strength decreases and the EASM increases. During this period, the southern Chinese mainland consisted of a wide arid zone while the northern Chinese mainland was much wetter. The arid zone in southern China resulted from two different types of monsoon processes: the abnormal northward extension of the EASM rain belt, leading to less rainfall in southeast China, or an illusion that the EASM weakened. The other process is a real weakening of the ISM. Second, during the BA interstadial, the strengths of both the ISM and EASM clearly increased. However, the maximum strengths appear to have occurred in the Allerød period. During this period, the entire Chinese mainland, both northern and southern, experienced wet conditions. The abnormal climate pattern of wet in the north and dry in the south during the YD stadial occurs because of the combined effects of the strengthened EASM, intensified westerlies, and weakened ISM, which could be attributed to the response to the abrupt cooling in the high northern latitudes and to the El Niño-like activity in the equatorial Pacific. The widespread wet climate during the BA interstadial may be related to an abrupt increase in the greenhouse gases (GHGs) concentrations in the atmosphere and to the La Niña-like activity in the equatorial Pacific. These results contribute to a better

  17. Case of neuroleptic malignant-like syndrome precipitated by abrupt fava bean discontinuance.

    PubMed

    Ladha, Shafeeq S; Walker, Russell; Shill, Holly A

    2005-05-01

    Neuroleptic malignant-like syndrome (NMLS) is well described in the treatment of Parkinson's disease. The syndrome is characterized by fever, rigidity, autonomic instability, elevated creatine phosphokinase levels, and altered level of consciousness, which is usually precipitated by levodopa withdrawal. In recent years, patients have used fava beans to treat Parkinson's symptoms, because the beans contain appreciable amounts of levodopa and have been thought to be a safe adjunctive therapy. We describe a case of NMLS, which was precipitated by the abrupt cessation of fava bean ingestion. PMID:15719433

  18. Tree ring correlation between prehistoric landslides and abrupt tectonic events in Seattle, washington.

    PubMed

    Jacoby, G C; Williams, P L; Buckley, B M

    1992-12-01

    Radiocarbon ages of submerged trees on landslide deposits in Lake Washington, Seattle, indicate that the most recent slides in three separate areas may have occurred simultaneously about 1000 years ago. Tree ring crossdating shows that seven bark-bearing trees from one of these recent slides and a tree 23 kilometers to the northwest in a probable tsunami deposit on the shore of Puget Sound died in the same season of the same year. The close coincidence among the most recent lake landslides, a probable tsunami, abrupt subsidence, and other possible seismic events gives evidence for a strong prehistoric earthquake in the Seattle region. PMID:17742529

  19. Children's Restrictive Disclosure to Friends.

    ERIC Educational Resources Information Center

    Rotenberg, Ken J.; Sliz, Dave

    1988-01-01

    Children's restrictive disclosure to friends, which is a facet of intimate friendship, was investigated. It was found that children in kindergarten, second, and fourth grade showed restrictive disclosure to friends, and that greater disclosure of positive personal information to friends than to nonfriends was exhibited with age. (PCB)

  20. Diverted Total Synthesis of Promysalin Analogs Demonstrates That an Iron-Binding Motif Is Responsible for Its Narrow-Spectrum Antibacterial Activity.

    PubMed

    Steele, Andrew D; Keohane, Colleen E; Knouse, Kyle W; Rossiter, Sean E; Williams, Sierra J; Wuest, William M

    2016-05-11

    Promysalin is a species-specific Pseudomonad metabolite with unique bioactivity. To better understand the mode of action of this natural product, we synthesized 16 analogs utilizing diverted total synthesis (DTS). Our analog studies revealed that the bioactivity of promysalin is sensitive to changes within its hydrogen bond network whereby alteration has drastic biological consequences. The DTS library not only yielded three analogs that retained potency but also provided insights that resulted in the identification of a previously unknown ability of promysalin to bind iron. These findings coupled with previous observations hint at a complex multifaceted role of the natural product within the rhizosphere.

  1. Design of a pulsed-mode fluidic pump using a venturi-like reverse flow diverter. [With no packing glands, mechanical seals or moving parts

    SciTech Connect

    Smith, G.V.; Lewis, B.E.

    1987-02-01

    This report presents a design procedure for pulsed-mode, venturi-like reverse flow diverter (RFD) pumping systems. Design techniques are presented for systems in which the output line area is allowed to vary proportionally with the throat area of the RFD as well as situations in which the output line area is held constant. The results show that for cases in which the output line area is allowed to vary, an optimum RFD throat area exists for a given input pressure. For situations in which the output line area is held constant, the average output flow decreases in almost a linear fashion with increasing RFD throat area. 6 refs., 8 figs.

  2. Evolutionary rescue and adaptation to abrupt environmental change depends upon the history of stress.

    PubMed

    Gonzalez, Andrew; Bell, Graham

    2013-01-19

    Whether evolution will be rapid enough to rescue declining populations will depend upon population size, the supply of genetic variation, the degree of maladaptation and the historical direction of selection. We examined whether the level of environmental stress experienced by a population prior to abrupt environmental change affects the probability of evolutionary rescue (ER). Hundreds of populations of two species of yeast, Saccharomyces cerevisiae and Saccharomyces paradoxus were exposed to a range of sublethal concentrations of salt for approximately a hundred generations before transfer to a concentration of salt lethal to the ancestor (150 g l(-1) NaCl). The fitness of surviving populations of both species was a quadratic function of yield: fitness was greatest for large populations that had been selected on low salt concentrations (less than 20 g l(-1) NaCl) and small populations that had adapted to high salt (more than 80 g l(-1) NaCl). However, differences occurred between species in the probability of ER. The frequency of ER was positively correlated with salt concentration for S. cerevisiae, but negatively correlated with salt concentration in S. paradoxus. These results not only demonstrate that past environmental conditions can determine the probability of ER after abrupt environmental change, but also suggest that there may even be differences between closely related species that are worth further exploration.

  3. Modeling Abrupt Change in Global Sea Level Arising from Ocean - Ice-Sheet Interaction

    SciTech Connect

    Holland, David M

    2011-09-24

    It is proposed to develop, validate, and apply a coupled ocean ice-sheet model to simulate possible, abrupt future change in global sea level. This research is to be carried out collaboratively between an academic institute and a Department of Energy Laboratory (DOE), namely, the PI and a graduate student at New York University (NYU) and climate model researchers at the Los Alamos National Laboratory (LANL). The NYU contribution is mainly in the area of incorporating new physical processes into the model, while the LANL efforts are focused on improved numerics and overall model development. NYU and LANL will work together on applying the model to a variety of modeling scenarios of recent past and possible near-future abrupt change to the configuration of the periphery of the major ice sheets. The project's ultimate goal is to provide a robust, accurate prediction of future global sea level change, a feat that no fully-coupled climate model is currently capable of producing. This proposal seeks to advance that ultimate goal by developing, validating, and applying a regional model that can simulate the detailed processes involved in sea-level change due to ocean ice-sheet interaction. Directly modeling ocean ice-sheet processes in a fully-coupled global climate model is not a feasible activity at present given the near-complete absence of development of any such causal mechanism in these models to date.

  4. Tyre friction behaviour under abrupt wheel torque transients on slippery road surfaces: experimental analysis and modelling

    NASA Astrophysics Data System (ADS)

    Ivanović, Vladimir; Deur, Joško; Kostelac, Milan; Pentek, Tibor; Hrovat, Davor

    2011-10-01

    The paper shows that, during abrupt wheel torque transients for ice surface and low vehicle speeds, the tyre can develop significantly larger longitudinal force than the peak value of the tyre static curve. This so-called dynamic tyre friction potential (DTFP) effect has many influencing factors such as the rate of change of the wheel torque, the vehicle speed, and the tyre dwell time. The paper presents a detailed analysis of the DTFP behaviour based on the experimental data collected by using an in-wheel motor-based tyre test vehicle. The analysis results and an insight into the brush structure of a tyre model lead to the hypothesis that the different influencing factors may be predominantly explained by the bristle dwell time (BDT) effect. Following this hypothesis, the LuGre model of the tyre friction dynamics is extended with a physical BDT sub-model. The experimental validation results show that the proposed model can accurately capture the low-speed tyre-ice friction behaviour during abrupt wheel torque transients.

  5. Abrupt Holocene climate change as an important factor for human migration in West Greenland

    PubMed Central

    D’Andrea, William J.; Huang, Yongsong; Fritz, Sherilyn C.; Anderson, N. John

    2011-01-01

    West Greenland has had multiple episodes of human colonization and cultural transitions over the past 4,500 y. However, the explanations for these large-scale human migrations are varied, including climatic factors, resistance to adaptation, economic marginalization, mercantile exploration, and hostile neighborhood interactions. Evaluating the potential role of climate change is complicated by the lack of quantitative paleoclimate reconstructions near settlement areas and by the relative stability of Holocene temperature derived from ice cores atop the Greenland ice sheet. Here we present high-resolution records of temperature over the past 5,600 y based on alkenone unsaturation in sediments of two lakes in West Greenland. We find that major temperature changes in the past 4,500 y occurred abruptly (within decades), and were coeval in timing with the archaeological records of settlement and abandonment of the Saqqaq, Dorset, and Norse cultures, which suggests that abrupt temperature changes profoundly impacted human civilization in the region. Temperature variations in West Greenland display an antiphased relationship to temperature changes in Ireland over centennial to millennial timescales, resembling the interannual to multidecadal temperature seesaw associated with the North Atlantic Oscillation. PMID:21628586

  6. Photospheric and Coronal Observations of Abrupt Magnetic Restructuring in Two Flaring Active Regions

    NASA Astrophysics Data System (ADS)

    Petrie, Gordon

    2016-05-01

    For two major X-class flares observed by the Solar Dynamics Observatory (SDO) and the Solar TErrestrial RElations Observatory Ahead (STEREO-A) spacecraft when they were close to quadrature, we compare major, abrupt changes in the photospheric magnetic vector field to changes in the observed coronal magnetic structure during the two flares. The Lorentz force changes in strong photospheric fields within active regions are estimated from time series of SDO Helioseismic and Magnetic Imager (HMI) vector magnetograms. These show that the major changes occurred in each case near the main neutral line of the region and in two neighboring twisted opposite-polarity sunspots. In each case the horizontal parallel field strengthened significantly near the neutral line while the azimuthal field in the sunspots decreased, suggesting that a flux rope joining the two sunspots collapsed across the neutral line with reduced magnetic pressure because of a reduced field twist component. At the same time, the coronal extreme ultraviolet (EUV) loop structure was observed by the Atmospheric Imaging Assembly (AIA) onboard SDO and the Extreme Ultraviolet Imager (EUVI) on STEREO-A to decrease significantly in height during each eruption, discontinuous changes signifying ejection of magnetized plasma, and outward-propagating continuous but abrupt changes consistent with loop contraction. An asymmetry in the observed EUV loop changes during one of the flares matches an asymmetry in the photospheric magnetic changes associated with that flare. The observations are discussed in terms of the well-known tether-cutting and breakout flare initiation models.

  7. Abrupt reversal in ocean overturning during the Palaeocene/Eocene warm period.

    PubMed

    Nunes, Flavia; Norris, Richard D

    2006-01-01

    An exceptional analogue for the study of the causes and consequences of global warming occurs at the Palaeocene/Eocene Thermal Maximum, 55 million years ago. A rapid rise of global temperatures during this event accompanied turnovers in both marine and terrestrial biota, as well as significant changes in ocean chemistry and circulation. Here we present evidence for an abrupt shift in deep-ocean circulation using carbon isotope records from fourteen sites. These records indicate that deep-ocean circulation patterns changed from Southern Hemisphere overturning to Northern Hemisphere overturning at the start of the Palaeocene/Eocene Thermal Maximum. This shift in the location of deep-water formation persisted for at least 40,000 years, but eventually recovered to original circulation patterns. These results corroborate climate model inferences that a shift in deep-ocean circulation would deliver relatively warmer waters to the deep sea, thus producing further warming. Greenhouse conditions can thus initiate abrupt deep-ocean circulation changes in less than a few thousand years, but may have lasting effects; in this case taking 100,000 years to revert to background conditions.

  8. Deep-Sea Biodiversity Response to Abrupt Deglacial and Holocene Climate Changes

    NASA Astrophysics Data System (ADS)

    Yasuhara, M.

    2014-12-01

    High-resolution records of microfossil assemblages from deep-sea sediment cores covering the last 20,000 years in the North Atlantic Ocean were investigated to understand biotic responses to abrupt climate changes over decadal-centennial timescales. The results show pervasive control of deep-sea benthic species diversity by rapidly changing climate. Species diversity rapidly increased during abrupt stadial events during the last deglacial and the Holocene interglacial periods. These included the well-known Heinrich 1, the Younger Dryas, and the 8.2 ka events when the strength of Atlantic Meridional Overturning Circulation (AMOC) decreased. In addition, there is evidence for quasi-cyclic changes in biodiversity at a ~1500-year periodicity. Statistical analyses revealed that AMOC-driven bottom-water-temperature variability is a primary influence on deep-sea biodiversity. Our results may portend pervasive, synchronous and sudden ecosystem responses to human-induced changes to climate and ocean circulation in this century. Exceptionally highly resolved fossil records help us to understand past, present and future ecosystem responses to climate changes by bridging the gap between biological and palaeontological time-scales.

  9. Direct measurement of defect and dopant abruptness at high electron mobility ZnO homojunctions

    NASA Astrophysics Data System (ADS)

    Foster, G. M.; Faber, G.; Yao, Y.-F.; Yang, C. C.; Heller, E. R.; Look, D. C.; Brillson, L. J.

    2016-10-01

    Due to a strong Fermi-level mismatch, about 10% of the electrons in a 5-nm-thick highly Ga-doped ZnO (GZO) layer grown by molecular beam epitaxy at 250 °C on an undoped ZnO buffer layer transfer to the ZnO (Debye leakage), causing the measured Hall-effect mobility (μH) of the GZO/ZnO combination to remarkably increase from 34 cm2/V s, in thick GZO, to 64 cm2/V s. From previous characterization of the GZO, it is known that ND = [Ga] = 1.04 × 1021 and NA = [VZn] = 1.03 × 1020 cm-3, where ND, NA, and [VZn] are the donor, acceptor, and Zn-vacancy concentrations, respectively. In the ZnO, ND = 3.04 × 1019 and NA = 8.10 × 1018 cm-3. Assuming the interface is abrupt, theory predicts μH = 61 cm2/V s, with no adjustable parameters. The assumption of abruptness in [Ga] and [VZn] profiles is confirmed directly with a differential form of depth-resolved cathodoluminescence spectroscopy coupled with X-ray photoelectron spectroscopy. An anneal in Ar at 500 °C for 10 min somewhat broadens the profiles but causes no appreciable degradation in μH and other electrical properties.

  10. Geometry Transition in the Cocos Plate, from Flat-Steep to Constant Dip: Smooth or Abrupt?

    NASA Astrophysics Data System (ADS)

    Perez-Campos, X.; Clayton, R. W.; Brudzinski, M. R.; Valdés-González, C. M.; Cabral-Cano, E.; Arciniega-Ceballos, A.; Córdoba-Montiel, F.

    2013-05-01

    Subduction of the Cocos Plate beneath North America has a variable and complex behavior along the Middle-American Trench. Initially, its geometry was delineated from regional seismicity. In the last 10 years, seismic experiments have illuminated some details in the geometry. They have reported, from NW to SE an abrupt dip transition, from 50 to 26°, as the result of a tear that splits Cocos North from Cocos South; then there is a smooth transition to a horizontal geometry under central Mexico. Further southeast, under the Isthmus of Tehuantepec, the Cocos plate shows a constant ~26° subduction dip. This last transition has been assumed to be smooth from the sparse seismicity in the region. A first glimpse of the slab geometry under Oaxaca, shows the slab continues to be flat at least until 97.5°W longitude, where the slab suddenly changes to a ~55° dip to the northeast. This occurs at a distance of ~75 km from the Pico de Orizaba volcano, which is a similar distance as the active Popocatepetl volcano from the place where the slab dives into the mantle along the Meso-American Subduction Experiment line, in central Mexico. East of this region, receiver function images show an abrupt change in the geometry and length of the slab.

  11. Abrupt changes in the southern extent of North Atlantic Deep Water during Dansgaard-Oeschger events

    NASA Astrophysics Data System (ADS)

    Gottschalk, Julia; Skinner, Luke C.; Misra, Sambuddha; Waelbroeck, Claire; Menviel, Laurie; Timmermann, Axel

    2015-12-01

    The glacial climate system transitioned rapidly between cold (stadial) and warm (interstadial) conditions in the Northern Hemisphere. This variability, referred to as Dansgaard-Oeschger variability, is widely believed to arise from perturbations of the Atlantic Meridional Overturning Circulation. Evidence for such changes during the longer Heinrich stadials has been identified, but direct evidence for overturning circulation changes during Dansgaard-Oeschger events has proven elusive. Here we reconstruct bottom water [CO32-] variability from B/Ca ratios of benthic foraminifera and indicators of sedimentary dissolution, and use these reconstructions to infer the flow of northern-sourced deep water to the deep central sub-Antarctic Atlantic Ocean. We find that nearly every Dansgaard-Oeschger interstadial is accompanied by a rapid incursion of North Atlantic Deep Water into the deep South Atlantic. Based on these results and transient climate model simulations, we conclude that North Atlantic stadial-interstadial climate variability was associated with significant Atlantic overturning circulation changes that were rapidly transmitted across the Atlantic. However, by demonstrating the persistent role of Atlantic overturning circulation changes in past abrupt climate variability, our reconstructions of carbonate chemistry further indicate that the carbon cycle response to abrupt climate change was not a simple function of North Atlantic overturning.

  12. Abrupt changes in deep-sea ecosystem structure and biodiversity during the last deglaciation and Holocene

    NASA Astrophysics Data System (ADS)

    Yasuhara, M.; Cronin, T. M.; Hunt, G.

    2008-12-01

    Recent research on deep-sea sediment cores suggests that the structure and diversity of deep-sea ecosystems exhibit greater instability over millennial and centennial timescales than previously realized. Centennial scale ecosystem shifts during the last deglaciation (Termination 1, 18-11.5 ka) and the Holocene (11.5 ka to recent) have been discovered using several well-dated deep-sea microfossil records. In the northwestern Atlantic ODP site 1055, weakening of North Atlantic Deep Water production around 10 ka appears to have caused the collapse of the deep-sea benthic ecosystem and reduced diversity at ca. 1800 meters water depth. During this and other Holocene events, diversity as measured by the Shannon Index was reduced by as much as 50%. Several lower resolution records also suggest rapid ecosystem change during Termination 1 in the central and northern North Atlantic region. For example, sites 82-24-4PC (mid-Atlantic Ridge) and M23414 (Rockall Plateau) reveal abrupt diversity shifts probably associated with bottom-water temperature and surface productivity changes. This presentation will assemble data on these and other fossil ostracod records from North Atlantic deep-sea sites to discuss possible causes of abrupt ecosystem changes and the application of Ostracoda to paleoceanography.

  13. A Sediment Record of Abrupt Lake Level Change in West-Central Minnesota

    NASA Astrophysics Data System (ADS)

    Mueller, S. B.; Triplett, L. D.; Myrbo, A.; Clotts, R. A.; Russell, J. M.; Shapley, M. D.

    2001-12-01

    Records of historical events preserved in lacustrine sediments are valuable for testing the conceptual models used in paleolimnology. The effects of climatic forcing and internal hydrologic dynamics are typically commingled in the geochemical signatures in sediments. However, Campbell Lake, Becker County, Minnesota, provides a record of abrupt lake-level drop unrelated to climate: in 1915 ditching reduced the lake surface area from 250 to 40 hectares and its average depth from three meters to one meter. We use sediment cores to assess the lake's response to this documented forcing, within the context of natural long-term variability. Existing paleoclimate studies from lakes in the region, as well as the historical record of anthropogenic impact to the lake, also make Campbell Lake a natural site to evaluate models of carbon and sulfur storage and carbon and oxygen stable isotope response to hydrologic changes. Loss-on-ignition and 210Pb chronology show only a slight increase in sedimentation rate following the drainage event, rather than the expected sharp increase due to reworking of littoral sediments. There is a dramatic rise in sedimentation rate around 1960, which may be indirectly related to the 1915 decrease in lake depth. The top 30 cm of sediment contains abundant carbonate stem casts from charophyte algae, indicating a shift to the lake's modern condition of aquatic macrophyte dominance. The time lag between lake-level drop and its manifestation in the sediments suggests that abrupt forcing events may not always be immediately reflected in the paleorecord.

  14. Banning Fisheries Discards Abruptly Has a Negative Impact on the Population Dynamics of Charismatic Marine Megafauna

    PubMed Central

    Fondo, Esther N.; Chaloupka, Milani; Heymans, Johanna J.; Skilleter, Greg A.

    2015-01-01

    Food subsidies have the potential to modify ecosystems and affect the provision of goods and services. Predictable Anthropogenic Food Subsidies (PAFS) modify ecosystems by altering ecological processes and food webs. The global concern over the effects of PAFS in ecosystems has led to development of environmental policies aimed at curbing the production or ultimately banning of PAFS. However, the effects of reducing or banning PAFS are not known. We explore the consequences of PAFS removal in a marine ecosystem under two scenarios: 1) gradual reduction, or 2) an abrupt ban, using a mass balance model to test these hypotheses–The reduction or loss of PAFS will: i) modify trophic levels and food webs through effects on foraging by opportunistic species, ii) increase the resilience of opportunistic species to food shortages, and iii) modify predator–prey interactions through shifts in prey consumption. We found that PAFS lower the trophic levels of opportunistic scavengers and increase their food pathways. Scavengers are able to switch prey when PAFS are reduced gradually but they decline when PAFS are abruptly banned. PAFS reduction to a certain minimal level causes a drop in the ecosystem’s stability. We recommend gradual reduction of PAFS to a minimal level that would maintain the ecosystem’s stability and allow species exploiting PAFS to habituate to the food subsidy reduction. PMID:26657412

  15. Abrupt termination of the 2012 Pacific warming and its implication on ENSO prediction

    NASA Astrophysics Data System (ADS)

    Su, Jingzhi; Xiang, Baoqiang; Wang, Bin; Li, Tim

    2014-12-01

    In the summer of 2012, there was a clear signal of the developing El Niño over the equatorial Pacific, and many climate models forecasted the occurrence of El Niño with a peak phase in the subsequent winter. However, the warming was aborted abruptly in late fall. Here we show that the abrupt termination of the 2012 Pacific warming was largely attributed to the anomalous sea surface temperature (SST) cooling in the northeastern and southeastern subtropical Pacific. The anomalous SST cooling induced strong easterly and low-level divergence anomalies, suppressing the development of westerly and convection anomalies over the equatorial central Pacific. Thus, the surface warming over the equatorial Pacific was decoupled from the surface wind forcing and subsurface thermocline variability, inhibiting its further development into a mature El Niño in the winter of 2012-2013. This study highlights the importance of the SST anomaly in the subtropical Pacific in El Niño prediction.

  16. Banning Fisheries Discards Abruptly Has a Negative Impact on the Population Dynamics of Charismatic Marine Megafauna.

    PubMed

    Fondo, Esther N; Chaloupka, Milani; Heymans, Johanna J; Skilleter, Greg A

    2015-01-01

    Food subsidies have the potential to modify ecosystems and affect the provision of goods and services. Predictable Anthropogenic Food Subsidies (PAFS) modify ecosystems by altering ecological processes and food webs. The global concern over the effects of PAFS in ecosystems has led to development of environmental policies aimed at curbing the production or ultimately banning of PAFS. However, the effects of reducing or banning PAFS are not known. We explore the consequences of PAFS removal in a marine ecosystem under two scenarios: 1) gradual reduction, or 2) an abrupt ban, using a mass balance model to test these hypotheses-The reduction or loss of PAFS will: i) modify trophic levels and food webs through effects on foraging by opportunistic species, ii) increase the resilience of opportunistic species to food shortages, and iii) modify predator-prey interactions through shifts in prey consumption. We found that PAFS lower the trophic levels of opportunistic scavengers and increase their food pathways. Scavengers are able to switch prey when PAFS are reduced gradually but they decline when PAFS are abruptly banned. PAFS reduction to a certain minimal level causes a drop in the ecosystem's stability. We recommend gradual reduction of PAFS to a minimal level that would maintain the ecosystem's stability and allow species exploiting PAFS to habituate to the food subsidy reduction.

  17. Abrupt transitions to a cold North Atlantic in the late Holocene

    NASA Astrophysics Data System (ADS)

    Geirsdóttir, Áslaug; Miller, Gifford; Larsen, Darren; Florian, Christopher; Pendleton, Simon

    2015-04-01

    The Holocene provides a time interval with boundary conditions similar to present, except for greenhouse gas concentrations. Recent high-resolution Northern Hemisphere records show general cooling related to orbital terms through the late Holocene, but also highly non-linear abrupt departures of centennial scale summer cold periods. These abrupt departures are evident within the last two millennia (the transitions between the Roman Warm Period (RWP, ~2,000 yr BP), the Dark Ages Cold Period (DACP, ~500-900 years AD), the Medieval Warm Period (MWP, 1000-1200 years AD) and the Little Ice Age (LIA, ~1300-1900 AD). A series of new, high-resolution and securely dated lake records from Iceland also show abrupt climate departures over the past 2 ka, characterized by shifts to persistent cold summers and an expanded cryosphere. Despite substantial differences in catchment-specific processes that dominate the lake records, the multi-proxy reconstructions are remarkably similar. After nearly a millennium with little evidence of significant climate shifts, the beginning of the first millennium AD is characterized by renewed summer cooling that leads to an expanding cryosphere. Slow summer cooling over the first five centuries is succeeded by widespread substantial cooling, with evidence for substantial expansion of glaciers and ice caps throughout our field areas between 530 and 900 AD, and an accompanying reduction in vegetation cover across much of Iceland that led to widespread landscape instability. These data suggest that the North Atlantic system began a transition into a new cold state early in the first millennium AD, which was amplified after 500 AD, until it was interrupted by warmer Medieval times between ~1000 and 1250 AD. Although severe soil erosion in Iceland is frequently associated with human settlement dated to 871 ±2 AD our reconstructions indicate that soil erosion began several centuries before settlement, during the DACP, whereas for several centuries

  18. Maternal Early Pregnancy Serum Metabolomics Profile and Abnormal Vaginal Bleeding as Predictors of Placental Abruption: A Prospective Study

    PubMed Central

    Gelaye, Bizu; Sumner, Susan J.; McRitchie, Susan; Carlson, James E.; Ananth, Cande V.; Enquobahrie, Daniel A.; Qiu, Chunfang; Sorensen, Tanya K.; Williams, Michelle A.

    2016-01-01

    Background & Objective Placental abruption, an ischemic placental disorder, complicates about 1 in 100 pregnancies, and is an important cause of maternal and perinatal morbidity and mortality worldwide. Metabolomics holds promise for improving the phenotyping, prediction and understanding of pathophysiologic mechanisms of complex clinical disorders including abruption. We sought to evaluate maternal early pregnancy pre-diagnostic serum metabolic profiles and abnormal vaginal bleeding as predictors of abruption later in pregnancy. Methods Maternal serum was collected in early pregnancy (mean 16 weeks, range 15 to 22 weeks) from 51 abruption cases and 51 controls. Quantitative targeted metabolic profiles of serum were acquired using electrospray ionization liquid chromatography-mass spectrometry (ESI-LC-MS/MS) and the Absolute IDQ® p180 kit. Maternal sociodemographic characteristics and reproductive history were abstracted from medical records. Stepwise logistic regression models were developed to evaluate the extent to which metabolites aid in the prediction of abruption. We evaluated the predictive performance of the set of selected metabolites using a receiver operating characteristics (ROC) curve analysis and area under the curve (AUC). Results Early pregnancy vaginal bleeding, dodecanoylcarnitine/dodecenoylcarnitine (C12 / C12:1), and phosphatidylcholine acyl-alkyl C 38:1 (PC ae C38:1) strongly predict abruption risk. The AUC for these metabolites alone was 0.68, for early pregnancy vaginal bleeding alone was 0.65, and combined the AUC improved to 0.75 with the addition of quantitative metabolite data (P = 0.003). Conclusion Metabolomic profiles of early pregnancy maternal serum samples in addition to the clinical symptom, vaginal bleeding, may serve as important markers for the prediction of abruption. Larger studies are necessary to corroborate and validate these findings in other cohorts. PMID:27300725

  19. AGU Sonar Data Restriction Panel

    NASA Astrophysics Data System (ADS)

    The AGU Council accepted the report of the panel set up in February to study the issue of restriction by the U.S. Navy of access to high-resolution sonar data for the U.S. Exclusive Economic Zone. Panel chairman John Bossier announced that “the Navy has acted in the best interests of the nation” in lifting the restriction order. Only two areas, egress routes to two submarine bases (see “Navy Defines Areas Under Sonar Ban,” in News, this issue), remain restricted.Panel members were Bruce Douglas, Alexander Malahoff, Donald Piepgras, Paul Richards, David Smith and Manik Talwani.

  20. Drivers and Dynamics of Ecological Responses to Abrupt Environmental Change on the Early Miocene Oregon Shelf

    NASA Astrophysics Data System (ADS)

    Belanger, C. L.

    2012-12-01

    We know that the biosphere responds to abrupt climate change, but know less about the dynamics of those changes and their proximal drivers. Studies of well-preserved fossil time-series spanning past climate events that utilize multiple environmental proxies and examine multiple taxonomic groups can provide critical insight into (a) the specific environmental factors to which the biota respond, (b) the rate and tempo of those responses, and (c) whether taxonomic groups respond similarly or differently to the same stresses. I examine the drivers and dynamics of ecological changes in continental shelf benthic foraminifera and molluscs from the Early Miocene Newport Member of the Astoria Formation in Oregon (20.3-16.3 mya), which spans a time of global warming leading into the Middle Miocene Climate Optimum. Stable isotope (δ18O) data from three species of benthic foraminifera from the Astoria sediments indicate that the region abruptly warmed by 2-4°C approximately 19 mya. In addition, δ13C values from epifaunal and infaunal foraminifera indicate an increase in productivity and organic carbon flux over time. Further, an increase in δ15N from bulk sediment and an increase in sedimentary laminations suggest oxygen levels declined. Multivariate analyses demonstrate a strong correlation between foraminiferal community metrics and δ15N suggesting that the foraminiferal community is tracking oxygenation levels while correlations to productivity changes appear indirect. Molluscan community metrics also have an approximately linear relationship to δ15N. Temperature itself had little direct influence on community composition. Changes in community composition and structure of both the foraminifera and the molluscs are abrupt relative to the duration of community states, but each group responds differently to the climate change. The foraminiferal community increases in the number of species and the evenness of species abundances while the molluscan community decreases in

  1. Transonic Experimental Observations of Abrupt Wing Stall on an F/A-18E Model (Invited)

    NASA Technical Reports Server (NTRS)

    McMillin, S. Naomi; Hall, Robert M.; Lamar, John E.

    2003-01-01

    A transonic wind tunnel test of an 8% F/A-18E model was conducted in the NASA Langley Research Center (LaRC) 16 ft Transonic Tunnel (16-ft TT) to investigate on-surface flow physics during stall. The technical approach employed focused on correlating static (or time-averaged) and unsteady wind-tunnel test data to the unsteady wing-stall events using force, moment, pressure, and pressure-sensitive-paint measurements. This paper focuses on data obtained on the pre-production configuration of the F/A-18E aircraft at Mach number of 0.90. The flow unsteadiness occurring on the wing as the wing went through the stall process was captured using the time history of balance and pressure measurements and by calculating the root mean square (RMS) for a number of instrument signals. The second step was to gather global perspectives on the pressures influencing the wing stall process. The abrupt wing stall experienced by the 8% F/A-18E Model was observed to be an unsteady event triggered by the rapid advancement of separation, which had migrated forward from the trailing edge, to the leading-edge flap hingeline over a very small increment in angle of attack. The angle of attack at which this stall occurred varied, from run to run, over an 1 deg increment. The abrupt wing stall was observed, using pressure-sensitive-paint, to occur simultaneously on both wing panels or asymmetrically. The pressure-sensitive paint data and wingroot bending moment data were essential in providing insight to the flow structures occurring over the wing and the possible asymmetry of those flow structures. A repeatability analysis conducted on eight runs of static data provided a quick and inexpensive examination of the unsteady aerodynamic characteristics of abrupt wing stall. The results of the repeatability analysis agreed extremely well with data obtained using unsteady measurement techniques. This approach could be used to identify test conditions for more complex unsteady data measurements using

  2. Progesterone administration reduces the behavioural and physiological responses of ewes to abrupt weaning of lambs.

    PubMed

    Freitas-de-Melo, A; Banchero, G; Hötzel, M J; Damián, J P; Ungerfeld, R

    2013-08-01

    Abrupt weaning, a usual management in sheep productive systems, may provoke behavioural and physiological responses indicative of stress in ewes and lambs. Progesterone (P4) has anxiolytic and sedative effects through the union of its metabolites that contain 3α-hydroxyl group to the γ-aminobutyricacidA receptor. Our first aim was to determine whether P4 administration reduces the behavioural and physiological responses of ewes to abrupt weaning of lambs. A complementary aim was to determine whether P4 treatment affects the milk yield and composition of ewes, and the BW of their lambs. In experiment 1, seven ewes received P4 treatment for 32 days (group E1-P4), and eight ewes remained as an untreated control group (group E1-C). BW of the lambs was recorded during P4 treatment. Lambs were weaned at 59 days (Day 0 = weaning). The main behaviours of the ewes before and after weaning were recorded using 10 min scan sampling. The ewes' serum total protein, albumin and globulin concentrations were measured before and after weaning of the lambs. In experiment 2, milk yield and composition were determined in two different groups of six ewes treated with P4 (group E2-P4) for 16 days and in five untreated controls (group E2-C). The BW of lambs increased with time (P = 0.001) in both groups and did not differ. The percentage of observations in which the ewes were seen pacing on Day 0 was greater in the E1-C group than in the E1-P4 group (P = 0.0007). Similarly, the percentage of observations in which the ewes were recorded vocalizing on Day 0 was greater in the E1-C group than in the E1-P4 group (P = 0.04). The percentage of observations in which E1-C ewes were recorded lying did not change from Days 0 to 1; however, it increased in E1-P4 ewes. Total serum protein concentration did not change in E1-P4 ewes from Days 0 to 3, although a decrease was seen in E1-C ewes (P = 0.04). Serum globulin concentration was greater in E1-P4 ewes on Day 3 than in E1-C ewes (P = 0.0008). In

  3. Effects of Early, Abrupt Weaning on HIV-free Survival of Children in Zambia

    PubMed Central

    Kuhn, Louise; Aldrovandi, Grace M.; Sinkala, Moses; Kankasa, Chipepo; Semrau, Katherine; Mwiya, Mwiya; Kasonde, Prisca; Scott, Nancy; Vwalika, Cheswa; Walter, Jan; Bulterys, Marc; Tsai, Wei-Yann; Thea, Donald M.

    2008-01-01

    Background In low-resource settings, many programs recommend that women who are infected with the human immunodeficiency virus (HIV) stop breast-feeding early. We conducted a randomized trial to evaluate whether abrupt weaning at 4 months as compared with the standard practice has a net benefit for HIV-free survival of children. Methods We enrolled 958 HIV-infected women and their infants in Lusaka, Zambia. All the women planned to breast-feed exclusively to 4 months; 481 were randomly assigned to a counseling program that encouraged abrupt weaning at 4 months, and 477 to a program that encouraged continued breast-feeding for as long as the women chose. The primary outcome was either HIV infection or death of the child by 24 months. Results In the intervention group, 69.0% of the mothers stopped breast-feeding at 5 months or earlier; 68.8% of these women reported the completion of weaning in less than 2 days. In the control group, the median duration of breast-feeding was 16 months. In the overall cohort, there was no significant difference between the groups in the rate of HIV-free survival among the children; 68.4% and 64.0% survived to 24 months without HIV infection in the intervention and control groups, respectively (P = 0.13). Among infants who were still being breast-fed and were not infected with HIV at 4 months, there was no significant difference between the groups in HIV-free survival at 24 months (83.9% and 80.7% in the intervention and control groups, respectively; P = 0.27). Children who were infected with HIV by 4 months had a higher mortality by 24 months if they had been assigned to the intervention group than if they had been assigned to the control group (73.6% vs. 54.8%, P = 0.007). Conclusions Early, abrupt cessation of breast-feeding by HIV-infected women in a low-resource setting, such as Lusaka, Zambia, does not improve the rate of HIV-free survival among children born to HIV-infected mothers and is harmful to HIV-infected infants

  4. Methionine restriction and lifespan control

    PubMed Central

    Lee, Byung Cheon; Kaya, Alaattin; Gladyshev, Vadim N.

    2016-01-01

    Dietary restriction (DR) without malnutrition is associated with longevity in various organisms. However, it has also been shown that reduced calorie intake is often ineffective in extending lifespan. Selecting optimal dietary regimens for DR studies is complicated, as the same regimen may lead to different outcomes depending on genotype and environmental factors. Recent studies suggested that interventions such as moderate protein restriction with/without adequate nutrition (e.g. particular amino acids or carbohydrates) may have additional beneficial effects mediated by certain metabolic and hormonal factors implicated in the biology of aging, regardless of total calorie intake. In particular, it was shown that restriction of a single amino acid, methionine, can mimic the effects of DR and extend lifespan in various model organisms. We discuss beneficial effects of methionine-restricted (MR) diet, the molecular pathways involved, and the use of this regimen in longevity interventions. PMID:26663138

  5. Therapeutic amnioinfusion for chronic abruption-oligohydramnios sequence: a possible prevention of the infant respiratory disease.

    PubMed

    Morita, Ayako; Kondoh, Eiji; Kawasaki, Kaoru; Fujita, Kohei; Mogami, Haruta; Minamiguchi, Sachiko; Konishi, Ikuo

    2014-04-01

    Chronic abruption-oligohydramnios sequence (CAOS), characterized by chronic vaginal bleeding and oligohydramnios, is associated with adverse pregnancy outcomes, including preterm delivery and lung problems in the infant. Fetal lung damage may be induced by not only oligohydramnios but also iron-induced oxidative stress through chronic aspiration of bloody substances in amniotic fluid. We describe a pregnancy complicated with CAOS that was managed with repeated amnioinfusions. This is the first report showing that amnioinfusions succeeded in a significant reduction in high concentrations of iron, lactose dehydrogenase, and 8-hydroxy-2'-deoxyguanosine, a marker of oxidative DNA damage, in the amniotic fluid complicated by CAOS. The baby, born at 26 weeks' gestation via cesarean, was discharged home without supplemental oxygen 116 days after birth.

  6. Abrupt decrease in tropical Pacific sea surface salinity at end of Little Ice Age.

    PubMed

    Hendy, Erica J; Gagan, Michael K; Alibert, Chantal A; McCulloch, Malcolm T; Lough, Janice M; Isdale, Peter J

    2002-02-22

    A 420-year history of strontium/calcium, uranium/calcium, and oxygen isotope ratios in eight coral cores from the Great Barrier Reef, Australia, indicates that sea surface temperature and salinity were higher in the 18th century than in the 20th century. An abrupt freshening after 1870 occurred simultaneously throughout the southwestern Pacific, coinciding with cooling tropical temperatures. Higher salinities between 1565 and 1870 are best explained by a combination of advection and wind-induced evaporation resulting from a strong latitudinal temperature gradient and intensified circulation. The global Little Ice Age glacial expansion may have been driven, in part, by greater poleward transport of water vapor from the tropical Pacific.

  7. Direct Measurement of the Electrical Abruptness of a Nanowire p-n Junction.

    PubMed

    Darbandi, Ali; McNeil, James C; Akhtari-Zavareh, Azadeh; Watkins, Simon P; Kavanagh, Karen L

    2016-07-13

    Electrostatic potential maps of GaAs nanowire, p-n junctions have been measured via off-axis electron holography and compared to results from in situ electrical probing, and secondary electron emission microscopy using scanning electron microscopy. The built-in potential and depletion length of an axial junction was found to be 1.5 ± 0.1 V and 74 ± 9 nm, respectively, to be compared with 1.53 V and 64 nm of an abrupt junction of the same end point carrier concentrations. Associated with the switch from Te to Zn dopant precursor was a reduction in GaAs nanowire diameter 3 ± 1 nm that occurred prior to the junction center (n = p) and was followed by a rapid increase in Zn doping. The delay in Zn incorporation is attributed to the time required for Zn to equilibrate within the Au catalyst. PMID:27254390

  8. Compact bending sensor based on a fiber Bragg grating in an abrupt biconical taper.

    PubMed

    Cui, Wei; Si, Jinhai; Chen, Tao; Hou, Xun

    2015-05-01

    We propose and experimentally demonstrate a compact bending sensor. The head of the sensor is only 0.8 mm in length, and consists of an abrupt biconical fiber taper formed using a conventional fusion splicer, in which a fiber Bragg grating (FBG) is inscribed using a femtosecond laser. The biconical taper incorporating the FBG can couple light from the cladding to the backward-propagating core mode, which realizes an interferometer in reflection-mode. Bending of the structure can be detected from the contrast change of interference fringes. A configuration to measure curvature is investigated to demonstrate the sensing characteristics. The temperature cross-sensitivity of the sensor is studied, and the results demonstrate that it is insensitive to temperature. PMID:25969198

  9. North Atlantic ocean circulation and abrupt climate change during the last glaciation

    NASA Astrophysics Data System (ADS)

    Henry, L. G.; McManus, J. F.; Curry, W. B.; Roberts, N. L.; Piotrowski, A. M.; Keigwin, L. D.

    2016-07-01

    The most recent ice age was characterized by rapid and hemispherically asynchronous climate oscillations, whose origin remains unresolved. Variations in oceanic meridional heat transport may contribute to these repeated climate changes, which were most pronounced during marine isotope stage 3, the glacial interval 25 thousand to 60 thousand years ago. We examined climate and ocean circulation proxies throughout this interval at high resolution in a deep North Atlantic sediment core, combining the kinematic tracer protactinium/thorium (Pa/Th) with the deep water-mass tracer, epibenthic δ13C. These indicators suggest reduced Atlantic overturning circulation during every cool northern stadial, with the greatest reductions during episodic Hudson Strait iceberg discharges, while sharp northern warming followed reinvigorated overturning. These results provide direct evidence for the ocean’s persistent, central role in abrupt glacial climate change.

  10. North Atlantic ocean circulation and abrupt climate change during the last glaciation.

    PubMed

    Henry, L G; McManus, J F; Curry, W B; Roberts, N L; Piotrowski, A M; Keigwin, L D

    2016-07-29

    The most recent ice age was characterized by rapid and hemispherically asynchronous climate oscillations, whose origin remains unresolved. Variations in oceanic meridional heat transport may contribute to these repeated climate changes, which were most pronounced during marine isotope stage 3, the glacial interval 25 thousand to 60 thousand years ago. We examined climate and ocean circulation proxies throughout this interval at high resolution in a deep North Atlantic sediment core, combining the kinematic tracer protactinium/thorium (Pa/Th) with the deep water-mass tracer, epibenthic δ(13)C. These indicators suggest reduced Atlantic overturning circulation during every cool northern stadial, with the greatest reductions during episodic Hudson Strait iceberg discharges, while sharp northern warming followed reinvigorated overturning. These results provide direct evidence for the ocean's persistent, central role in abrupt glacial climate change.

  11. Theory and Design Tools For Studies of Reactions to Abrupt Changes in Noise Exposure

    NASA Technical Reports Server (NTRS)

    Fields, James M.; Ehrlich, Gary E.; Zador, Paul; Shepherd, Kevin P. (Technical Monitor)

    2000-01-01

    Study plans, a pre-tested questionnaire, a sample design evaluation tool, a community publicity monitoring plan, and a theoretical framework have been developed to support combined social/acoustical surveys of residents' reactions to an abrupt change in environmental noise, Secondary analyses of more than 20 previous surveys provide estimates of three parameters of a study simulation model; within individual variability, between study wave variability, and between neighborhood variability in response to community noise. The simulation model predicts the precision of the results from social surveys of reactions to noise, including changes in noise. When the study simulation model analyzed the population distribution, noise exposure environments and feasible noise measurement program at a proposed noise change survey site, it was concluded that the site could not yield sufficient precise estimates of human reaction model to justify conducting a survey. Additional secondary analyses determined that noise reactions are affected by the season of the social survey.

  12. Abrupt climate changes for Iceland during the last millennium: Evidence from high resolution sea ice reconstructions

    NASA Astrophysics Data System (ADS)

    Massé, Guillaume; Rowland, Steven J.; Sicre, Marie-Alexandrine; Jacob, Jeremy; Jansen, Eystein; Belt, Simon T.

    2008-05-01

    A high resolution account of Icelandic sea ice over the last millennium has been constructed using a novel proxy based on the presence in sediments of a biomarker (IP 25) produced by sea ice algae. Comparison with historical sea ice records demonstrates a strong correlation between documented sea ice occurrences and the IP 25 proxy. An excellent agreement is also observed between the IP 25 record and a diatom-based sea surface temperature reconstruction obtained from the same core and the Crowley and Lowery Northern Hemisphere temperature reconstruction. Using this approach, we provide new historical sea ice data for periods where records are scarce or absent and evidence for abrupt changes to sea ice and/or climate conditions around Iceland during the Little Ice Age.

  13. North Atlantic ocean circulation and abrupt climate change during the last glaciation.

    PubMed

    Henry, L G; McManus, J F; Curry, W B; Roberts, N L; Piotrowski, A M; Keigwin, L D

    2016-07-29

    The most recent ice age was characterized by rapid and hemispherically asynchronous climate oscillations, whose origin remains unresolved. Variations in oceanic meridional heat transport may contribute to these repeated climate changes, which were most pronounced during marine isotope stage 3, the glacial interval 25 thousand to 60 thousand years ago. We examined climate and ocean circulation proxies throughout this interval at high resolution in a deep North Atlantic sediment core, combining the kinematic tracer protactinium/thorium (Pa/Th) with the deep water-mass tracer, epibenthic δ(13)C. These indicators suggest reduced Atlantic overturning circulation during every cool northern stadial, with the greatest reductions during episodic Hudson Strait iceberg discharges, while sharp northern warming followed reinvigorated overturning. These results provide direct evidence for the ocean's persistent, central role in abrupt glacial climate change. PMID:27365315

  14. Paleoclimate. Synchronization of North Pacific and Greenland climates preceded abrupt deglacial warming.

    PubMed

    Praetorius, Summer K; Mix, Alan C

    2014-07-25

    Some proposed mechanisms for transmission of major climate change events between the North Pacific and North Atlantic predict opposing patterns of variations; others suggest synchronization. Resolving this conflict has implications for regulation of poleward heat transport and global climate change. New multidecadal-resolution foraminiferal oxygen isotope records from the Gulf of Alaska (GOA) reveal sudden shifts between intervals of synchroneity and asynchroneity with the North Greenland Ice Core Project (NGRIP) δ(18)O record over the past 18,000 years. Synchronization of these regions occurred 15,500 to 11,000 years ago, just prior to and throughout the most abrupt climate transitions of the last 20,000 years, suggesting that dynamic coupling of North Pacific and North Atlantic climates may lead to critical transitions in Earth's climate system. PMID:25061208

  15. Automated detection of sperm whale sounds as a function of abrupt changes in sound intensity

    NASA Astrophysics Data System (ADS)

    Walker, Christopher D.; Rayborn, Grayson H.; Brack, Benjamin A.; Kuczaj, Stan A.; Paulos, Robin L.

    2003-04-01

    An algorithm designed to detect abrupt changes in sound intensity was developed and used to identify and count sperm whale vocalizations and to measure boat noise. The algorithm is a MATLAB routine that counts the number of occurrences for which the change in intensity level exceeds a threshold. The algorithm also permits the setting of a ``dead time'' interval to prevent the counting of multiple pulses within a single sperm whale click. This algorithm was used to analyze digitally sampled recordings of ambient noise obtained from the Gulf of Mexico using near bottom mounted EARS buoys deployed as part of the Littoral Acoustic Demonstration Center experiment. Because the background in these data varied slowly, the result of the application of the algorithm was automated detection of sperm whale clicks and creaks with results that agreed well with those obtained by trained human listeners. [Research supported by ONR.

  16. On the calculation of turbulent heat transport downstream from an abrupt pipe expansion

    NASA Technical Reports Server (NTRS)

    Chieng, C. C.; Launder, B. E.

    1980-01-01

    A numerical study is reported of flow and heat transfer in the separated flow region created by an abrupt pipe expansion. Computations employed an adaptation of the TEACH-2E computer program with the standard model of turbulence. Emphasis is given to the simulation, from both a physical and numerical viewpoint, of the region in the immediate vicinity of the wall where turbulent transport gives way to molecular conduction and diffusion. Wall resistance laws or wall functions used to bridge this near-wall region are based on the idea that, beyond the viscous sublayer, the turbulent length scale is universal, increasing linearly with distance from the wall. Predictions of expermental data for a diameter ratio of 0.54 show generally encouraging agreement with experiment. At a diameter of 0.43 different trends are discernible between measurement and calculation though this appears to be due to effects unconnected with the wall region studied.

  17. On the calculation of turbulent heat transport downstream from an abrupt pipe expansion

    NASA Technical Reports Server (NTRS)

    Chieng, C. C.; Launder, B. E.

    1980-01-01

    A numerical study of flow and heat transfer in the separated flow region produced by an abrupt pipe explosion is reported, with emphasis on the region in the immediate vicinity of the wall where turbulent transport gives way to molecular conduction and diffusion. The analysis is based on a modified TEACH-2E program with the standard k-epsilon model of turbulence. Predictions of the experimental data of Zemanick and Dougall (1970) for a diameter ratio of 0.54 show generally encouraging agreement with experiment. At a diameter ratio of 0.43 different trends are discernable between measurement and calculation, though this appears to be due to effects unconnected with the wall region studied here.

  18. Occultation by a protoplanetary clump in the young abrupt variable GM Cepheid

    NASA Astrophysics Data System (ADS)

    Chen, W. P.; Hu, S. C.-L.; Su, B. H.; Lee, C. D.; Lin, C. C.; Huang, C. K.; Wang, P. F.; Chiang, P. S.; Lee, C. H.; Sato, S.

    2013-06-01

    GM Cephei (GM Cep) is an active T Tauri star in the young (˜ 4 Myr) open cluster Trumpler 37, showing abrupt UX Orionis type of photometric variability. Chen et al. (2012) reported frequent, sporadic brightening events, each of < 0.5 mag and lasting for days, which must have been originated from circumstellar accretion. In addition, the star also showed a brightness drop of ˜ 1 mag lasting continuously for about a month, during which time the star became bluer when fainter. Moreover, the brightness drops seem to have a recurrence timescale of a year. It is proposed that the drop is the consequence of obscuration of the central star by an orbiting dust concentration, exemplifying disk inhomogeneity in transition between grain coagulation and planetesimal formation in a young circumstellar disk. The star was found to exhibit a few percent polarization in the optical wavelengths, and an enhanced level of polarization during the occultation.

  19. Synchronous centennial abrupt events in the ocean and atmosphere during the last deglaciation

    NASA Astrophysics Data System (ADS)

    Chen, Tianyu; Robinson, Laura F.; Burke, Andrea; Southon, John; Spooner, Peter; Morris, Paul J.; Ng, Hong Chin

    2015-09-01

    Antarctic ice-core data reveal that the atmosphere experienced abrupt centennial increases in CO2 concentration during the last deglaciation (~18 thousand to 11 thousand years ago). Establishing the role of ocean circulation in these changes requires high-resolution, accurately dated marine records. Here, we report radiocarbon data from uranium-thorium-dated deep-sea corals in the Equatorial Atlantic and Drake Passage over the past 25,000 years. Two major deglacial radiocarbon shifts occurred in phase with centennial atmospheric CO2 rises at 14.8 thousand and 11.7 thousand years ago. We interpret these radiocarbon-enriched signals to represent two short-lived (less than 500 years) “overshoot” events, with Atlantic meridional overturning stronger than that of the modern era. These results provide compelling evidence for a close coupling of ocean circulation and centennial climate events during the last deglaciation.

  20. Direct observation of an abrupt insulator-to-metal transition in dense liquid deuterium

    NASA Astrophysics Data System (ADS)

    Knudson, M. D.; Desjarlais, M. P.; Becker, A.; Lemke, R. W.; Cochrane, K. R.; Savage, M. E.; Bliss, D. E.; Mattsson, T. R.; Redmer, R.

    2015-06-01

    Eighty years ago, it was proposed that solid hydrogen would become metallic at sufficiently high density. Despite numerous investigations, this transition has not yet been experimentally observed. More recently, there has been much interest in the analog of this predicted metallic transition in the dense liquid, due to its relevance to planetary science. Here, we show direct observation of an abrupt insulator-to-metal transition in dense liquid deuterium. Experimental determination of the location of this transition provides a much-needed benchmark for theory and may constrain the region of hydrogen-helium immiscibility and the boundary-layer pressure in standard models of the internal structure of gas-giant planets.

  1. Abrupt uplift within the past 1700 years at Southern Puget Sound, Washington

    USGS Publications Warehouse

    Bucknam, R.C.; Hemphill-Haley, E.; Leopold, E.B.

    1992-01-01

    Shorelines rose as much as 7 meters along southern Puget Sound and Hood Canal between 500 and 1700 years ago. Evidence for this uplift consists of elevated wave-cut shore platforms near Seattle and emerged, peat-covered tidal flats as much as 60 kilometers to the southwest. The uplift was too rapid for waves to leave intermediate shorelines on even the best preserved platform. The tidal flats also emerged abruptly; they changed into freshwater swamps and meadows without first becoming tidal marshes. Where uplift was greatest, it adjoined an inferred fault that crosses Puget Sound at Seattle and it probably accompanied reverse slip on that fault 1000 to 1100 years ago. The uplift and probable fault slip show that the crust of the North America plate contains potential sources of damaging earthquakes in the Puget Sound region.

  2. Abrupt fire regime change may cause landscape-wide loss of mature obligate seeder forests.

    PubMed

    Bowman, David M J S; Murphy, Brett P; Neyland, Dominic L J; Williamson, Grant J; Prior, Lynda D

    2014-03-01

    Obligate seeder trees requiring high-severity fires to regenerate may be vulnerable to population collapse if fire frequency increases abruptly. We tested this proposition using a long-lived obligate seeding forest tree, alpine ash (Eucalyptus delegatensis), in the Australian Alps. Since 2002, 85% of the Alps bioregion has been burnt by several very large fires, tracking the regional trend of more frequent extreme fire weather. High-severity fires removed 25% of aboveground tree biomass, and switched fuel arrays from low loads of herbaceous and litter fuels to high loads of flammable shrubs and juvenile trees, priming regenerating stands for subsequent fires. Single high-severity fires caused adult mortality and triggered mass regeneration, but a second fire in quick succession killed 97% of the regenerating alpine ash. Our results indicate that without interventions to reduce fire severity, interactions between flammability of regenerating stands and increased extreme fire weather will eliminate much of the remaining mature alpine ash forest.

  3. Optofluidic realization and retaining of cell–cell contact using an abrupt tapered optical fibre

    PubMed Central

    Xin, Hongbao; Zhang, Yao; Lei, Hongxiang; Li, Yayi; Zhang, Huixian; Li, Baojun

    2013-01-01

    Studies reveal that there exists much interaction and communication between bacterial cells, with parts of these social behaviors depending on cell–cell contacts. The cell–cell contact has proved to be crucial for determining various biochemical processes. However, for cell culture with relatively low cell concentration, it is difficult to precisely control and retain the contact of a small group of cells. Particularly, the retaining of cell–cell contact is difficult when flows occur in the medium. Here, we report an optofluidic method for realization and retaining of Escherichia coli cell–cell contact in a microfluidic channel using an abrupt tapered optical fibre. The contact process is based on launching a 980-nm wavelength laser into the fibre, E. coli cells were trapped onto the fibre tip one after another, retaining cell–cell contact and forming a highly organized cell chain. The formed chains further show the ability as bio-optical waveguides. PMID:23771190

  4. Abrupt fire regime change may cause landscape-wide loss of mature obligate seeder forests.

    PubMed

    Bowman, David M J S; Murphy, Brett P; Neyland, Dominic L J; Williamson, Grant J; Prior, Lynda D

    2014-03-01

    Obligate seeder trees requiring high-severity fires to regenerate may be vulnerable to population collapse if fire frequency increases abruptly. We tested this proposition using a long-lived obligate seeding forest tree, alpine ash (Eucalyptus delegatensis), in the Australian Alps. Since 2002, 85% of the Alps bioregion has been burnt by several very large fires, tracking the regional trend of more frequent extreme fire weather. High-severity fires removed 25% of aboveground tree biomass, and switched fuel arrays from low loads of herbaceous and litter fuels to high loads of flammable shrubs and juvenile trees, priming regenerating stands for subsequent fires. Single high-severity fires caused adult mortality and triggered mass regeneration, but a second fire in quick succession killed 97% of the regenerating alpine ash. Our results indicate that without interventions to reduce fire severity, interactions between flammability of regenerating stands and increased extreme fire weather will eliminate much of the remaining mature alpine ash forest. PMID:24132866

  5. Transition process of abrupt climate change based on global sea surface temperature over the past century

    NASA Astrophysics Data System (ADS)

    Yan, Pengcheng; Hou, Wei; Feng, Guolin

    2016-05-01

    A new detection method has been proposed to study the transition process of abrupt climate change. With this method, the climate system transiting from one stable state to another can be verified clearly. By applying this method to the global sea surface temperature over the past century, several climate changes and their processes are detected, including the start state (moment), persist time, and end state (moment). According to the spatial distribution, the locations of climate changes mainly have occurred in the Indian Ocean and western Pacific before the middle twentieth century, in the 1970s in the equatorial middle-eastern Pacific, and in the middle and southern Pacific since the end of the twentieth century. In addition, the quantitative relationship between the transition process parameters is verified in theory and practice: (1) the relationship between the rate and stability parameters is linear, and (2) the relationship between the rate and change amplitude parameters is quadratic.

  6. DES of turbulent vortex breakdown in an abrupt axisymmetric expansion at Re = 10^5.

    NASA Astrophysics Data System (ADS)

    Paik, Joongcheol; Sotiropoulos, Fotis

    2007-11-01

    Turbulent swirling incompressible flow through an abrupt axisymmetric expansion at Re = 100,000 is investigated numerically using detached-eddy simulation. The effects of swirl intensity on the coherent dynamics of the flow are systematically studied by carrying out numerical simulations over a range of swirl numbers from 0.17 to 1.23. Comparisons of computed solutions and the experimental measurements of Dellenback et al. [AIAA Journal. Vol 26, pp. 669-681] show that the numerical simulations resolve both axial and swirling mean velocity profiles and corresponding turbulence statistics with very good accuracy. Coherent structure visualizations with the q-criterion and Lagrangian particle tracking are used to elucidate the rich dynamics of the flow as a function of the swirl number with emphasis on the various modes of vortex breakdown and other large scale instabilities in the shear layers and along the pipe wall.

  7. Laurentide Ice Sheet meltwater and abrupt climate change during the last glaciation

    SciTech Connect

    Hill, H W; Flower, B P; Quinn, T M; Hollander, D J; Guilderson, T P

    2005-10-02

    A leading hypothesis to explain abrupt climate change during the last glacial cycle calls on fluctuations in the margin of the North American Laurentide Ice Sheet (LIS), which may have routed freshwater between the Gulf of Mexico (GOM) and North Atlantic, affecting North Atlantic Deep Water (NADW) variability and regional climate. Paired measurements of {delta}O and Mg/Ca of foraminiferal calcite from GOM sediments reveal five episodes of LIS meltwater input from 28-45 thousand years ago (ka) that do not match the millennial-scale Dansgaard-Oeschger (D/O) warmings recorded in Greenland ice. We suggest that summer melting of the LIS may occur during Antarctic warming and likely contributed to sea-level variability during Marine Isotope Stage 3 (MIS 3).

  8. The chronology of abrupt climate change and Late Upper Palaeolithic human adaptation in Europe

    NASA Astrophysics Data System (ADS)

    Blockley, S. P. E.; Blockley, S. M.; Donahue, R. E.; Lane, C. S.; Lowe, J. J.; Pollard, A. M.

    2006-07-01

    This paper addresses the possible connections between the onset of human expansion in Europe following the Last Glacial Maximum, and the timing of abrupt climate warming at the onset of the Lateglacial (Bölling/Allerød) Interstadial. There are opposing views as to whether or not human populations and activities were directly forced by climate change, based on different comparisons between archaeological and environmental data. We review the geochronological assumptions and approaches on which data comparisons have been attempted in the past, and argue that the uncertainties presently associated with age models based on calibrated radiocarbon dates preclude robust testing of the competing models, particularly when comparing the data to non-radiocarbon-based timescales such as the Greenland ice core records. The paper concludes with some suggestions as to the steps that will be necessary if more robust tests of the models are to be developed in the future. Copyright

  9. Abrupt switch to migratory night flight in a wild migratory songbird

    PubMed Central

    Zúñiga, Daniel; Falconer, Jade; Fudickar, Adam M.; Jensen, Willi; Schmidt, Andreas; Wikelski, Martin; Partecke, Jesko

    2016-01-01

    Every year, billions of wild diurnal songbirds migrate at night. To do so, they shift their daily rhythm from diurnality to nocturnality. In captivity this is observed as a gradual transition of daytime activity developing into nocturnal activity, but how wild birds prepare their daily rhythms for migration remains largely unknown. Using an automated radio-telemetry system, we compared activity patterns of free-living migrant and resident European blackbirds (Turdus merula) in a partially migratory population during the pre-migratory season. We found that activity patterns between migrant and resident birds did not differ during day and night. Migrants did not change their daily rhythm in a progressive manner as has been observed in captivity, but instead abruptly became active during the night of departure. The rapid shift in rhythmicity might be more common across migratory songbird species, but may not have been observed before in wild animals due to a lack of technology. PMID:27666200

  10. Synchronous centennial abrupt events in the ocean and atmosphere during the last deglaciation.

    PubMed

    Chen, Tianyu; Robinson, Laura F; Burke, Andrea; Southon, John; Spooner, Peter; Morris, Paul J; Ng, Hong Chin

    2015-09-25

    Antarctic ice-core data reveal that the atmosphere experienced abrupt centennial increases in CO2 concentration during the last deglaciation (~18 thousand to 11 thousand years ago). Establishing the role of ocean circulation in these changes requires high-resolution, accurately dated marine records. Here, we report radiocarbon data from uranium-thorium-dated deep-sea corals in the Equatorial Atlantic and Drake Passage over the past 25,000 years. Two major deglacial radiocarbon shifts occurred in phase with centennial atmospheric CO2 rises at 14.8 thousand and 11.7 thousand years ago. We interpret these radiocarbon-enriched signals to represent two short-lived (less than 500 years) "overshoot" events, with Atlantic meridional overturning stronger than that of the modern era. These results provide compelling evidence for a close coupling of ocean circulation and centennial climate events during the last deglaciation.

  11. Synchronous centennial abrupt events in the ocean and atmosphere during the last deglaciation.

    PubMed

    Chen, Tianyu; Robinson, Laura F; Burke, Andrea; Southon, John; Spooner, Peter; Morris, Paul J; Ng, Hong Chin

    2015-09-25

    Antarctic ice-core data reveal that the atmosphere experienced abrupt centennial increases in CO2 concentration during the last deglaciation (~18 thousand to 11 thousand years ago). Establishing the role of ocean circulation in these changes requires high-resolution, accurately dated marine records. Here, we report radiocarbon data from uranium-thorium-dated deep-sea corals in the Equatorial Atlantic and Drake Passage over the past 25,000 years. Two major deglacial radiocarbon shifts occurred in phase with centennial atmospheric CO2 rises at 14.8 thousand and 11.7 thousand years ago. We interpret these radiocarbon-enriched signals to represent two short-lived (less than 500 years) "overshoot" events, with Atlantic meridional overturning stronger than that of the modern era. These results provide compelling evidence for a close coupling of ocean circulation and centennial climate events during the last deglaciation. PMID:26404835

  12. Climatic and Societal Causes for Abrupt Environmental Change in the Mediterranean During the Common Era

    NASA Astrophysics Data System (ADS)

    Mensing, S. A.; Tunno, I.; Sagnotti, L.; Florindo, F.; Noble, P. J.; Archer, C.; Zimmerman, S. R. H.; Pavón-Carrasco, F. J.; Cifnani, G.; Passigli, S.; Piovesan, G.

    2015-12-01

    We compare climatic and societal causes for abrupt environmental change for the last 2000 years in the Rieti Basin, central Italy using high-resolution sedimentary paleoenvironmental proxies, historical documents, and annually resolved independent climate reconstructions of temperature and precipitation. Pollen zones, identified from temporally constrained cluster analysis, coincide with historic periods developed from well-established ceramic sequences corresponding to the Roman Imperial through Late Antique (1 to 600 CE) Early Medieval (600 to 875 CE), Medieval through Late Medieval (875 to 1400 CE), Renaissance and Modern (1400 to 1725 CE), and Contemporary periods (1725 CE to present). Non-metric dimensional scaling (NMDS) ordination showed that each temporal period occupied a unique ecologic space suggesting that a new landscape was created during each successive historic period. During Roman time, between 1 and 500 CE, a modest decline in forest coincides with a positive phase of the North Atlantic Oscillation (NAO) and drier climate; however mesophyllous forest is preserved. Steep decline in forest cover between 850 and 950 CE coincides with positive temperature anomalies in Europe and a positive NAO. Although this would seem to suggest climate as a cause, temperature and precipitation changes are modest and the magnitude and rapidity of the vegetation change suggests climate played a small role. Archaeological evidence from across Europe identifies socioeconomic factors that produced forest clearing. In contrast, cooler temperatures and a negative NAO (increased ppt) appears to have been a catalyst for land abandonment and forest recovery in the 13th to 14th centuries. The NAO produces opposite effects on societies in the eastern and western Mediterranean with the negative phase in 1400 CE leading to cool wet climate and land abandonment in central Italy but an abrupt shift to drier conditions and change from sedentary village life to nomadism in Syria.

  13. Cooperation of the BTB-Zinc finger protein, Abrupt, with cytoskeletal regulators in Drosophila epithelial tumorigenesis.

    PubMed

    Turkel, Nezaket; Portela, Marta; Poon, Carole; Li, Jason; Brumby, Anthony M; Richardson, Helena E

    2015-01-01

    The deregulation of cell polarity or cytoskeletal regulators is a common occurrence in human epithelial cancers. Moreover, there is accumulating evidence in human epithelial cancer that BTB-ZF genes, such as Bcl6 and ZBTB7A, are oncogenic. From our previous studies in the vinegar fly, Drosophila melanogaster, we have identified a cooperative interaction between a mutation in the apico-basal cell polarity regulator Scribble (Scrib) and overexpression of the BTB-ZF protein Abrupt (Ab). Herein, we show that co-expression of ab with actin cytoskeletal regulators, RhoGEF2 or Src64B, in the developing eye-antennal epithelial tissue results in the formation of overgrown amorphous tumours, whereas ab and DRac1 co-expression leads to non-cell autonomous overgrowth. Together with ab, these genes affect the expression of differentiation genes, resulting in tumours locked in a progenitor cell fate. Finally, we show that the expression of two mammalian genes related to ab, Bcl6 and ZBTB7A, which are oncogenes in mammalian epithelial cancers, significantly correlate with the upregulation of cytoskeletal genes or downregulation of apico-basal cell polarity neoplastic tumour suppressor genes in colorectal, lung and other human epithelial cancers. Altogether, this analysis has revealed that upregulation of cytoskeletal regulators cooperate with Abrupt in Drosophila epithelial tumorigenesis, and that high expression of human BTB-ZF genes, Bcl6 and ZBTB7A, shows significant correlations with cytoskeletal and cell polarity gene expression in specific epithelial tumour types. This highlights the need for further investigation of the cooperation between these genes in mammalian systems.

  14. Abrupt climate change and transient climates during the Paleogene: a marine perspective

    NASA Technical Reports Server (NTRS)

    Zachos, J. C.; Lohmann, K. C.; Walker, J. C.; Wise, S. W.

    1993-01-01

    Detailed investigations of high latitude sequences recently collected by the Ocean Drilling Program (ODP) indicate that periods of rapid climate change often culminated in brief transient climates, with more extreme conditions than subsequent long term climates. Two examples of such events have been identified in the Paleogene; the first in latest Paleocene time in the middle of a warming trend that began several million years earlier: the second in earliest Oligocene time near the end of a Middle Eocene to Late Oligocene global cooling trend. Superimposed on the earlier event was a sudden and extreme warming of both high latitude sea surface and deep ocean waters. Imbedded in the latter transition was an abrupt decline in high latitude temperatures and the brief appearance of a full size continental ice-sheet on Antarctica. In both cases the climate extremes were not stable, lasting for less than a few hundred thousand years, indicating a temporary or transient climate state. Geochemical and sedimentological evidence suggest that both Paleogene climate events were accompanied by reorganizations in ocean circulation, and major perturbations in marine productivity and the global carbon cycle. The Paleocene-Eocene thermal maximum was marked by reduced oceanic turnover and decreases in global delta 13C and in marine productivity, while the Early Oligocene glacial maximum was accompanied by intensification of deep ocean circulation and elevated delta 13C and productivity. It has been suggested that sudden changes in climate and/or ocean circulation might occur as a result of gradual forcing as certain physical thresholds are exceeded. We investigate the possibility that sudden reorganizations in ocean and/or atmosphere circulation during these abrupt transitions generated short-term positive feedbacks that briefly sustained these transient climatic states.

  15. Cooperation of the BTB-Zinc finger protein, Abrupt, with cytoskeletal regulators in Drosophila epithelial tumorigenesis

    PubMed Central

    Turkel, Nezaket; Portela, Marta; Poon, Carole; Li, Jason; Brumby, Anthony M.; Richardson, Helena E.

    2015-01-01

    ABSTRACT The deregulation of cell polarity or cytoskeletal regulators is a common occurrence in human epithelial cancers. Moreover, there is accumulating evidence in human epithelial cancer that BTB-ZF genes, such as Bcl6 and ZBTB7A, are oncogenic. From our previous studies in the vinegar fly, Drosophila melanogaster, we have identified a cooperative interaction between a mutation in the apico-basal cell polarity regulator Scribble (Scrib) and overexpression of the BTB-ZF protein Abrupt (Ab). Herein, we show that co-expression of ab with actin cytoskeletal regulators, RhoGEF2 or Src64B, in the developing eye-antennal epithelial tissue results in the formation of overgrown amorphous tumours, whereas ab and DRac1 co-expression leads to non-cell autonomous overgrowth. Together with ab, these genes affect the expression of differentiation genes, resulting in tumours locked in a progenitor cell fate. Finally, we show that the expression of two mammalian genes related to ab, Bcl6 and ZBTB7A, which are oncogenes in mammalian epithelial cancers, significantly correlate with the upregulation of cytoskeletal genes or downregulation of apico-basal cell polarity neoplastic tumour suppressor genes in colorectal, lung and other human epithelial cancers. Altogether, this analysis has revealed that upregulation of cytoskeletal regulators cooperate with Abrupt in Drosophila epithelial tumorigenesis, and that high expression of human BTB-ZF genes, Bcl6 and ZBTB7A, shows significant correlations with cytoskeletal and cell polarity gene expression in specific epithelial tumour types. This highlights the need for further investigation of the cooperation between these genes in mammalian systems. PMID:26187947

  16. Remote Detection and Modeling of Abrupt and Gradual Tree Mortality in the Southwestern USA

    NASA Astrophysics Data System (ADS)

    Muss, J. D.; Xu, C.; McDowell, N. G.

    2014-12-01

    Current climate models predict a warming and drying trend that has a high probability of increasing the frequency and spatial extent of tree mortality events. Field surveys can be used to identify, date, and attribute a cause of mortality to specific trees, but monetary and time constraints prevent broad-scale surveys, which are necessary to establish regional or global trends in tree mortality. This is significant because widespread forest mortality will likely lead to radical changes in evapotranspiration and surface albedo, which could compound climate change. While understanding the causes and mechanisms of tree mortality events is crucial, it is equally important to be able to detect and monitor mortality and subsequent changes to the ecosystem at broad spatial- and temporal-scales. Over the past five years our ability to remotely detect abrupt forest mortality events has improved greatly, but gradual events—such as those caused by drought or certain types of insects—are still difficult to identify. Moreover, it is virtually impossible to quantify the amount of mortality that has occurred within a mixed pixel. We have developed a system that fuses climate and satellite-derived spectral data to identify both the date and the agent of forest mortality events. This system has been used with Landsat time series data to detect both abrupt and general trends in tree loss that have occurred during the past quarter-century in northern New Mexico. It has also been used with MODIS data to identify pixels with a high likelihood of drought-caused tree mortality in the Southwestern US. These candidate pixels were then fed to ED-FRT, a coupled forest dynamics-radiative transfer model, to generate estimates of drought-induced. We demonstrate a multi-scale approach that can produce results that will be instrumental in advancing our understanding of tree mortality-climate feedbacks, and improve our ability to predict what forests could look like in the future.

  17. Hydrological response to an abrupt shift in surface air temperature over France in 1987/88

    NASA Astrophysics Data System (ADS)

    Brulebois, Etienne; Castel, Thierry; Richard, Yves; Chateau-Smith, Carmela; Amiotte-Suchet, Philippe

    2015-12-01

    During the last few decades, Europe has seen a faster increase of observed temperature than that simulated by models. The air temperature over Western Europe showed an abrupt shift at the end of the 1980s, still insufficiently documented. The aim of this study is to assess the characteristics of this shift and its potential impacts on the hydrological cycle over France. Such an assessment is essential for a better understanding of past and future climatic changes and their impact on water resources. A subset of 119 temperature, 122 rainfall, and 30 hydrometric stations was studied, over the entire French metropolitan territory. Several change-point detection tests were applied to temperature, rainfall and runoff time series. A shift in annual mean air temperature was detected in 1987/88, for more than 75% of the stations, and for both minimum and maximum temperatures. An abrupt increase of about 1 °C in minimum and maximum temperature provides evidence of this shift, which shows strong seasonality, with significant increases for DJF, MAM and JJA. Its detection is not affected by the length of the time series or any potential artefacts associated to the conditions of measurement. Cluster analysis of the rainfall stations was used to take account of regional variability in rainfall evolution. Two climate areas were obtained from this analysis: Mediterranean and temperate. No shift was detected in rainfall for either area. However, at annual and quarterly scales, several changes in runoff were observed between the periods 1969-87 and 1988-09. The significant changes occurred from January to July, in agreement with maximum increases in temperature. Evapotranspiration could well play a key role in these changes in the hydrological cycle, as a response to temperature increases in the watersheds studied.

  18. Abrupt pre-Bølling-Allerød warming and circulation changes in the deep ocean.

    PubMed

    Thiagarajan, Nivedita; Subhas, Adam V; Southon, John R; Eiler, John M; Adkins, Jess F

    2014-07-01

    Several large and rapid changes in atmospheric temperature and the partial pressure of carbon dioxide in the atmosphere--probably linked to changes in deep ocean circulation--occurred during the last deglaciation. The abrupt temperature rise in the Northern Hemisphere and the restart of the Atlantic meridional overturning circulation at the start of the Bølling-Allerød interstadial, 14,700 years ago, are among the most dramatic deglacial events, but their underlying physical causes are not known. Here we show that the release of heat from warm waters in the deep North Atlantic Ocean probably triggered the Bølling-Allerød warming and reinvigoration of the Atlantic meridional overturning circulation. Our results are based on coupled radiocarbon and uranium-series dates, along with clumped isotope temperature estimates, from water column profiles of fossil deep-sea corals in a limited area of the western North Atlantic. We find that during Heinrich stadial 1 (the cool period immediately before the Bølling-Allerød interstadial), the deep ocean was about three degrees Celsius warmer than shallower waters above. This reversal of the ocean's usual thermal stratification pre-dates the Bølling-Allerød warming and must have been associated with increased salinity at depth to preserve the static stability of the water column. The depleted radiocarbon content of the warm and salty water mass implies a long-term disconnect from rapid surface exchanges, and, although uncertainties remain, is most consistent with a Southern Ocean source. The Heinrich stadial 1 ocean profile is distinct from the modern water column, that for the Last Glacial Maximum and that for the Younger Dryas, suggesting that the patterns we observe are a unique feature of the deglacial climate system. Our observations indicate that the deep ocean influenced dramatic Northern Hemisphere warming by storing heat at depth that preconditioned the system for a subsequent abrupt overturning event during the

  19. Extreme temperatures, foundation species, and abrupt ecosystem change: an example from an iconic seagrass ecosystem.

    PubMed

    Thomson, Jordan A; Burkholder, Derek A; Heithaus, Michael R; Fourqurean, James W; Fraser, Matthew W; Statton, John; Kendrick, Gary A

    2015-04-01

    Extreme climatic events can trigger abrupt and often lasting change in ecosystems via the reduction or elimination of foundation (i.e., habitat-forming) species. However, while the frequency/intensity of extreme events is predicted to increase under climate change, the impact of these events on many foundation species and the ecosystems they support remains poorly understood. Here, we use the iconic seagrass meadows of Shark Bay, Western Australia--a relatively pristine subtropical embayment whose dominant, canopy-forming seagrass, Amphibolis antarctica, is a temperate species growing near its low-latitude range limit--as a model system to investigate the impacts of extreme temperatures on ecosystems supported by thermally sensitive foundation species in a changing climate. Following an unprecedented marine heat wave in late summer 2010/11, A. antarctica experienced catastrophic (>90%) dieback in several regions of Shark Bay. Animal-borne video footage taken from the perspective of resident, seagrass-associated megafauna (sea turtles) revealed severe habitat degradation after the event compared with a decade earlier. This reduction in habitat quality corresponded with a decline in the health status of largely herbivorous green turtles (Chelonia mydas) in the 2 years following the heat wave, providing evidence of long-term, community-level impacts of the event. Based on these findings, and similar examples from diverse ecosystems, we argue that a generalized framework for assessing the vulnerability of ecosystems to abrupt change associated with the loss of foundation species is needed to accurately predict ecosystem trajectories in a changing climate. This includes seagrass meadows, which have received relatively little attention in this context. Novel research and monitoring methods, such as the analysis of habitat and environmental data from animal-borne video and data-logging systems, can make an important contribution to this framework. PMID:25145694

  20. Extreme temperatures, foundation species, and abrupt ecosystem change: an example from an iconic seagrass ecosystem.

    PubMed

    Thomson, Jordan A; Burkholder, Derek A; Heithaus, Michael R; Fourqurean, James W; Fraser, Matthew W; Statton, John; Kendrick, Gary A

    2015-04-01

    Extreme climatic events can trigger abrupt and often lasting change in ecosystems via the reduction or elimination of foundation (i.e., habitat-forming) species. However, while the frequency/intensity of extreme events is predicted to increase under climate change, the impact of these events on many foundation species and the ecosystems they support remains poorly understood. Here, we use the iconic seagrass meadows of Shark Bay, Western Australia--a relatively pristine subtropical embayment whose dominant, canopy-forming seagrass, Amphibolis antarctica, is a temperate species growing near its low-latitude range limit--as a model system to investigate the impacts of extreme temperatures on ecosystems supported by thermally sensitive foundation species in a changing climate. Following an unprecedented marine heat wave in late summer 2010/11, A. antarctica experienced catastrophic (>90%) dieback in several regions of Shark Bay. Animal-borne video footage taken from the perspective of resident, seagrass-associated megafauna (sea turtles) revealed severe habitat degradation after the event compared with a decade earlier. This reduction in habitat quality corresponded with a decline in the health status of largely herbivorous green turtles (Chelonia mydas) in the 2 years following the heat wave, providing evidence of long-term, community-level impacts of the event. Based on these findings, and similar examples from diverse ecosystems, we argue that a generalized framework for assessing the vulnerability of ecosystems to abrupt change associated with the loss of foundation species is needed to accurately predict ecosystem trajectories in a changing climate. This includes seagrass meadows, which have received relatively little attention in this context. Novel research and monitoring methods, such as the analysis of habitat and environmental data from animal-borne video and data-logging systems, can make an important contribution to this framework.

  1. Abrupt climate-triggered lake ecosystem changes recorded in late glacial lake sediments in northern Poland

    NASA Astrophysics Data System (ADS)

    Slowinski, M. M.; Zawiska, I.; Ott, F.; Noryskiewicz, A. M.; Apolinarska, K.; Lutynska, M.; Michczynska, D. J.; Brauer, A.; Wulf, S.; Skubala, P.; Blaszkiewicz, M.

    2013-12-01

    The aim of this study was to better understand how local lake ecosystems responded to abrupt climate changes through applying multi-proxy sediment analyses. Therefore, we carried out a detailed and high-resolution case study on the late glacial sediment from the Trzechowskie palaeolake located in the eastern part of the Pomeranian Lakeland, northern Poland. We reconstructed climate induced environmental changes in the paleolake and its catchment using biotic proxies (macrofossils, pollen, cladocera, diatoms, oribatidae mite) and classical geochemical proxies (δ18O, δ13C, loss-on-ignition, CaCO3 content) in combination with high-resolution μ-XRF element core scanning. The core chronology has been established by means of biostratigraphy, AMS 14C-dating on plant macro remains, varve counting in laminated intervals and tephrochronology. The latter was possible by the discovery of the late Allerød Laacher See Tephra for the first time at such eastern location. Biogenic accumulation in the lake started rather late during the lateglacial interstadial at 13903×170 cal yrs BP. The rapid and pronounced cooling at the beginning of the Younger Dryas had a major impact on the lake and its catchment as clearly reflected by both, biotic and geochemical proxies. The depositional environment of the lake abruptly changed from a varved to massive gytjia. The pronounced warming at the demise of Younger Dryas cooling is well-reflected in all environmental indicators but with conspicuous leads and lags reflecting complex responses of lake ecosystems to climate warming. The research was supported by the National Science Centre Poland - NN306085037. This study is a contribution to the Virtual Institute ICLEA (Integrated Climate and Landscape Evolution Analysis) funded by the Helmholtz Association.

  2. Antarctic Forcing of Abrupt Global Climate Change During Isotope Stage 3

    NASA Astrophysics Data System (ADS)

    Turney, Christian; Jones, Richard; Phipps, Steven; Thomas, Zoë; Hogg, Alan; Kershaw, Peter; Fogwill, Christopher; Palmer, Jonathan; Bronk Ramsey, Christopher; Adolphi, Florian; Muscheler, Raimund; Hughen, Konrad; Staff, Richard; Grosvenor, Mark; Golledge, Nicholas; Haberle, Simon

    2016-04-01

    Contrasting Greenland and Antarctic temperature trends during the late Pleistocene (60,000 to 11,650 years ago) are thought to be driven by imbalances in the rate of formation of North Atlantic and Antarctic Deep Water (the 'bipolar seesaw'), with millennial-scale cooling Dansgaard-Oeschger (D-O) events in the north leading warming in the south. An alternative origin for these abrupt climate shifts, however, is the Southern Hemisphere whereby changes are transmitted globally via atmospheric and/or oceanic teleconnections. Testing these competing hypotheses is challenging given the relatively large uncertainties associated with dating terrestrial, marine and ice core chronologies. Here we use a fully coupled climate system model to investigate whether freshening of the Southern Ocean has extra-regional climate impacts. Focusing on an Isotope Stage 3 cooling event preserved in Antarctic ice cores immediately prior to Antarctic Isotope Maximum 4 (AIM 4; around 29,000 years ago) we undertook an ensemble of transient meltwater simulations. We observe no impact on the Atlantic Meridional Overturning Circulation (AMOC) from freshwater hosing in the Southern Ocean but a dramatic warming over the North Atlantic and contrasting precipitation patterns across the low latitudes. Exploiting a new bidecadally-resolved 14C calibration dataset obtained from New Zealand kauri (Agathis australis) we undertook intensive radiocarbon dating and high-resolution multiproxy analysis of the tropical Australia Lynch's Crater terrestrial peat sequence spanning this same period and find a synchronous change in hydroclimate to the purported meltwater event in the Southern Ocean. Our results imply Southern Ocean dynamics played a significant role in driving global climate change across this period via atmospheric teleconnections, with implications for other abrupt events through the late Pleistocene.

  3. Abrupt increases in Amazonian tree mortality due to drought–fire interactions

    PubMed Central

    Brando, Paulo Monteiro; Balch, Jennifer K.; Nepstad, Daniel C.; Morton, Douglas C.; Putz, Francis E.; Coe, Michael T.; Silvério, Divino; Macedo, Marcia N.; Davidson, Eric A.; Nóbrega, Caroline C.; Alencar, Ane; Soares-Filho, Britaldo S.

    2014-01-01

    Interactions between climate and land-use change may drive widespread degradation of Amazonian forests. High-intensity fires associated with extreme weather events could accelerate this degradation by abruptly increasing tree mortality, but this process remains poorly understood. Here we present, to our knowledge, the first field-based evidence of a tipping point in Amazon forests due to altered fire regimes. Based on results of a large-scale, long-term experiment with annual and triennial burn regimes (B1yr and B3yr, respectively) in the Amazon, we found abrupt increases in fire-induced tree mortality (226 and 462%) during a severe drought event, when fuel loads and air temperatures were substantially higher and relative humidity was lower than long-term averages. This threshold mortality response had a cascading effect, causing sharp declines in canopy cover (23 and 31%) and aboveground live biomass (12 and 30%) and favoring widespread invasion by flammable grasses across the forest edge area (80 and 63%), where fires were most intense (e.g., 220 and 820 kW⋅m−1). During the droughts of 2007 and 2010, regional forest fires burned 12 and 5% of southeastern Amazon forests, respectively, compared with <1% in nondrought years. These results show that a few extreme drought events, coupled with forest fragmentation and anthropogenic ignition sources, are already causing widespread fire-induced tree mortality and forest degradation across southeastern Amazon forests. Future projections of vegetation responses to climate change across drier portions of the Amazon require more than simulation of global climate forcing alone and must also include interactions of extreme weather events, fire, and land-use change. PMID:24733937

  4. An abrupt slowdown of Atlantic Meridional Overturning Circulation during 1915-1935 induced by solar forcing in a coupled GCM

    NASA Astrophysics Data System (ADS)

    Lin, P.; Song, Y.; Yu, Y.; Liu, H.

    2014-06-01

    In this study, we explore an abrupt change of Atlantic Meridional Overturning Circulation (AMOC) apparent in the historical run simulated by the second version of the Flexible Global Ocean-Atmosphere-Land System model - Spectral Version 2 (FGOALS-s2). The abrupt change is noted during the period from 1915 to 1935, in which the maximal AMOC value is weakened beyond 6 Sv (1 Sv = 106 m3 s-1). The abrupt signal first occurs at high latitudes (north of 46° N), then shifts gradually to middle latitudes (∼35° N) three to seven years later. The weakened AMOC can be explained in the following. The weak total solar irradiance (TIS) during early twentieth century decreases pole-to-equator temperature gradient in the upper stratosphere. The North polar vortex is weakened, which forces a negative North Atlantic Oscillation (NAO) phase during 1905-1914. The negative phase of NAO induces anomalous easterly winds in 50-70° N belts, which decrease the release of heat fluxes from ocean to atmosphere and induce surface warming over these regions. Through the surface ice-albedo feedback, the warming may lead to continuously melting sea ice in Baffin Bay and Davis Strait, which results in freshwater accumulation. This can lead to salinity and density reductions and then an abrupt slowdown of AMOC. Moreover, due to increased TIS after 1914, the enhanced Atlantic northward ocean heat transport from low to high latitudes induces an abrupt warming of sea surface temperature or upper ocean temperature in mid-high latitudes, which can also weaken the AMOC. The abrupt change of AMOC also appears in the PiControl run, which is associated with the lasting negative NAO phases due to natural variability.

  5. A randomized, controlled trial of NRT-aided gradual vs. abrupt cessation in smokers actively trying to quit.

    PubMed

    Hughes, John R; Solomon, Laura J; Livingston, Amy E; Callas, Peter W; Peters, Erica N

    2010-09-01

    Most smoking cessation programs advise abrupt rather than gradual cessation. We conducted a randomized, controlled trial of gradual cessation (n=297) vs. abrupt cessation (n=299) vs. minimal treatment (n=150) among smokers who wanted to quit now and preferred to quit gradually. Participants were recruited via newspaper and radio advertisements. The gradual and abrupt conditions received five phone calls (total=90 min) and the minimal treatment condition received two calls (25 min total). The gradual condition received nicotine lozenge (via mail) to reduce smoking prior to their quit date. After the quit day, all participants received lozenge. The primary outcome was prolonged abstinence from 2 weeks post-quit day through 6 months. Prior to the quit day, the gradual condition decreased cigarettes/day by 54%, whereas the other two conditions decreased by 1% and 5%. Prolonged abstinence rates (CO<10 ppm) did not differ among gradual, abrupt and minimal treatment conditions (4%, 7% and 5%), nor did 7-day point prevalence rates (7%, 11% and 11%). Fewer smokers in the gradual condition (48%) made a quit attempt than in the abrupt (64%) or minimal (60%) conditions (p<.001). In the gradual condition, every week delay to the quit date increased the probability of lapsing by 19% (p<.001). We conclude that among smokers who want to stop gradually in the near future, gradual cessation with nicotine pre-treatment does not produce higher quit rates than abrupt cessation. One liability of gradual reduction may be that it allows smokers to delay their quit date. PMID:20537810

  6. Telomere Restriction Fragment (TRF) Analysis

    PubMed Central

    Mender, Ilgen; Shay, Jerry W.

    2016-01-01

    While telomerase is expressed in ~90% of primary human tumors, most somatic tissue cells except transiently proliferating stem-like cells do not have detectable telomerase activity (Shay and Wright, 1996; Shay and Wright, 2001). Telomeres progressively shorten with each cell division in normal cells, including proliferating stem-like cells, due to the end replication (lagging strand synthesis) problem and other causes such as oxidative damage, therefore all somatic cells have limited cell proliferation capacity (Hayflick limit) (Hayflick and Moorhead, 1961; Olovnikov, 1973). The progressive telomere shortening eventually leads to growth arrest in normal cells, which is known as replicative senescence (Shay et al., 1991). Once telomerase is activated in cancer cells, telomere length is stabilized by the addition of TTAGGG repeats to the end of chromosomes, thus enabling the limitless continuation of cell division (Shay and Wright, 1996; Shay and Wright, 2001). Therefore, the link between aging and cancer can be partially explained by telomere biology. There are many rapid and convenient methods to study telomere biology such as Telomere Restriction Fragment (TRF), Telomere Repeat Amplification Protocol (TRAP) (Mender and Shay, 2015b) and Telomere dysfunction Induced Foci (TIF) analysis (Mender and Shay, 2015a). In this protocol paper we describe Telomere Restriction Fragment (TRF) analysis to determine average telomeric length of cells. Telomeric length can be indirectly measured by a technique called Telomere Restriction Fragment analysis (TRF). This technique is a modified Southern blot, which measures the heterogeneous range of telomere lengths in a cell population using the length distribution of the terminal restriction fragments (Harley et al., 1990; Ouellette et al., 2000). This method can be used in eukaryotic cells. The description below focuses on the measurement of human cancer cells telomere length. The principle of this method relies on the lack of

  7. Abrupt Transitions in Climate Throughout the Holocene from a Lake Sediment Record in se Greenland

    NASA Astrophysics Data System (ADS)

    de Wet, G.; Bradley, R. S.; Balascio, N. L.

    2012-12-01

    Arctic climate variability over the Holocene has been both extensive and, at times, abrupt. Current understanding of these changes is still quite limited with few high-resolution paleoclimate records available for this period. In order to place observed and predicted 21st century climate change in perspective, reliable and highly resolved paleo-reconstructions of Arctic climate are essential. Using an 8.5 m sediment core from Nanerersarpik Lake, this project will characterize climate changes during the Holocene, including the deglacial transition, the rapid changes that are known to have occurred around 8,200 years ago, the transition from Holocene thermal maximum (HTM) to the colder Neoglacial period, and intervals of abrupt climate change during the late Holocene such as the Medieval Warm Period and Little Ice Age. The 8.5 m sediment core from Nanerersarpik contains a dense gray clay in the lower 0.5m. The upper 8.0m of sediment is light brown and organic-rich with centimeter to half-centimeter laminations, interrupted by mass-movement events. Paleoenvironmental conditions have been interpreted using magnetic susceptibility, grain size, biogenic silica, TOC, C/N, and δ13Corg, as well as with high-resolution spectral reflectance and scanning XRF profiles. These parameters allow us to interpret changes in autochthonous productivity and clastic input throughout the Holocene. A chronology for the record has been established using 210Pb and 11 radiocarbon dates. Cryptotephra analysis will also be carried out to improve the chronology during the Late Holocene. The age-model indicates Nanerersarpik Lake contains an ~8,500-yr sediment record with a linear age/depth relationship and a sedimentation rate of 0.1cm/yr, allowing for potentially decadal scale resolution of environmental changes. Preliminary results show an abrupt transition from dense glacial clay to laminated organic rich sediment near the base of the core. This is interpreted as marking the retreat of

  8. Agriculture, Settlement, and Abrupt Climate Change: The 4.2ka BP event in Northern Mesopotamia

    NASA Astrophysics Data System (ADS)

    Ristvet, L.

    2003-12-01

    An abrupt aridification event at 4200 BP has been recorded in 41 paleoclimate proxies in the Old World, from Kilmanjaro, Tanzania to Rajasthan, India, East Asia and the Pacific. This event is particularly well defined for Western Asia, where it has been associated with the abandonment of settlements across the Fertile Crescent and the collapse of states on the Levantine coast and in the dry-farming plains of Northern Mesopotamia, including the Akkadian Empire. Adaptations to climate change are constrained by both local environmental and social factors. Agriculturalists, especially those living in pre-industrial societies, are particularly susceptible to changes in precipitation. The Tell Leilan Regional Survey, which systematically studied sites in a 1650km2 area of Northeastern Syria, records one set of adaptations to this event in an area where dry-farming provided the subsistence base. The survey transect crosses ecotones, from the present 500mm isohyet in the North to the 250mm isohyet in the South, and contains diverse wadi systems, ground water resources, soil profiles, and an ancient marsh/lake-- all of which allow this region to be taken as a microcosm of Northern Mesopotamia. In order to contextualize our study of human response to abrupt climate change, it is necessary to consider how the economic and social systems that were previously in place were transformed by this event. This study attempts to quantify climate change and model its effects on agricultural, pastoral, and settlement systems in Northeastern Syria from 2400-1700 BC. From 2400-2300 BC, optimal climate conditions coincided with the consolidation of an indigenous state. The next century witnessed the Akkadian conquest and imperialization of the Habur plains, which resulted in both the intensification and extensification of agro-production. During the next 300 years, (2200-1900 BC), rainfall plummeted to 70% of the climatic optimum, triggering the abandonment of cities along with their

  9. Endothelialization of over- and undersized flow-diverter stents at covered vessel side branches: An in vivo and in silico study.

    PubMed

    Berg, Philipp; Iosif, Christina; Ponsonnard, Sebastien; Yardin, Catherine; Janiga, Gábor; Mounayer, Charbel

    2016-01-01

    Although flow-diverting devices are promising treatment options for intracranial aneurysms, jailed side branches might occlude leading to insufficient blood supply. Especially differences in the local stent strut compression may have a drastic influence on subsequent endothelialization. To investigate the outcome of different treatment scenarios, over- and undersized stent deployments were realized experimentally and computationally. Two Pipeline Embolization Devices were placed in the right common carotid artery of large white swine, crossing the right ascending pharyngeal artery. DSA and PC-MRI measurements were acquired pre- and post-stenting and after three months. To evaluate the stent strut endothelialization and the corresponding ostium patency, the swine were sacrificed and scanning electron microscopy measurements were carried out. A more detailed analysis of the near-stent hemodynamics was enabled by a realistic virtual stenting in combination with highly resolved Computational Fluid Dynamics simulations using case-specific boundary conditions. The oversizing resulted in an elongated stent deployment with more open stent pores, while for the undersized case a shorter deployment with more condensed pores was present. In consequence, the side branch of the first case remained patent after three months and the latter almost fully occluded. The virtual investigation confirmed the experimental findings by identifying differences between the individual velocities as well as stent shear stresses at the distal part of the ostia. The choice of flow-diverting device and the subsequent deployment strategy strongly influences the patency of jailed side branches. Therefore, careful treatment planning is required, to guarantee sufficient blood supply in the brain territories supplied those branches.

  10. Natural and abrupt involution of the mammary gland affects differently the metabolic and health consequences of weaning.

    PubMed

    Silanikove, Nissim

    2014-04-25

    In most mammals under natural conditions weaning is gradual. Weaning occurs after the mammary gland naturally produces much less milk than it did at peak and established lactation. Involution occurs following the cessation of milk evacuation from the mammary glands. The abrupt termination of the evacuation of milk from the mammary gland at peak and established lactation induces abrupt involution. Evidence on mice has shown that during abrupt involution, mammary gland utilizes some of the same tissue remodeling programs that are activated during wound healing. These results led to the proposition of the "involution hypothesis". According to the involution hypothesis, involution is associated with increased risk for developing breast cancer. However, the involution hypothesis is challenged by the metabolic and immunological events that characterize the involution process that follows gradual weaning. It has been shown that gradual weaning is associated with pre-adaption to the forthcoming break between dam and offspring and is followed by an orderly reprogramming of the mammary gland tissue. As discussed herein, such response may actually protect the mammary glands against the development of breast cancer and thus, may explain the protective effect of extended breastfeeding. On the other hand, the termination of breastfeeding during the first 6 months of lactation is likely associated with an abrupt involution and thus with an increased risk for developing breast cancer. Review of the literature on the epidemiology of breast cancer principally supports those conclusions.

  11. A Static Color Discontinuity Can Capture Spatial Attention when the Target Is an Abrupt-Onset Singleton

    ERIC Educational Resources Information Center

    Burnham, Bryan R.; Neely, James H.

    2008-01-01

    C. L. Folk, R. W. Remington, and J. C. Johnston's (1992) contingent involuntary orienting hypothesis states that a salient visual feature will involuntarily capture attention only when the observer's attentional set includes similar features. In four experiments, when the target's relevant feature was its being an abruptly onset singleton,…

  12. Possible mechanism of abrupt jump in winter surface air temperature in the late 1980s over the Northern Hemisphere

    PubMed Central

    Kim, Yeon‐Hee; Lau, William K. M.; Kim, Kyu‐Myong; Cho, Chun‐Ho

    2015-01-01

    Abstract Possible cause of an abrupt warming in winter mean surface air temperature in the midlatitudes of the Northern Hemisphere in the late 1980s is investigated using observation and reanalysis data. To determine the timing of abrupt warming, we use a regime shift index based on detection of the largest significant differences between the mean values of two contiguous periods. Results show that the abrupt warming occurred in association with a regime shift after the 1980's in which the zonal mean sea level pressure (SLP) is significantly increased (decreased) at the latitude 25–35°N (60–70°N), in the form of north‐south dipole‐like SLP anomaly spanning the subtropics and high latitude. The dipole SLP anomaly can be attributed to a northward expansion of Hadley cell, a poleward broadening and intensification of the Ferrel cell, coupled with a collapse of polar cell. During the abrupt warming, strong anomalous southerly warm advection at the surface was induced by an enhanced and expanded Ferrel circulation, in association with a northward and downward shift of maximum center of northward eddy heat flux over the midlatitudes. An intensification of polar jet subsequent to regime shift may be instrumental in sustaining the warming up to more than 5 years.

  13. Abrupt along-strike change in tectonic style: San Andreas Fault zone, San Francisco Peninsula

    NASA Astrophysics Data System (ADS)

    Zoback, Mary Lou; Jachens, Robert C.; Olson, Jean A.

    1999-05-01

    Seismicity and high-resolution aeromagnetic data are used to define an abrupt change from compressional to extensional tectonism within a 10- to 15-km-wide zone along the San Andreas fault on the San Francisco Peninsula and offshore from the Golden Gate. This 100-km-long section of the San Andreas fault includes the hypocenter of the Mw = 7.8 1906 San Francisco earthquake as well as the highest level of persistent microseismicity along that ˜470-km-long rupture. We define two distinct zones of deformation along this stretch of the fault using well-constrained relocations of all post-1969 earthquakes based a joint one-dimensional velocity/hypocenter inversion and a redetermination of focal mechanisms. The southern zone is characterized by thrust- and reverse-faulting focal mechanisms with NE trending P axes that indicate "fault-normal" compression in 7- to 10-km-wide zones of deformation on both sides of the San Andreas fault. A 1- to 2-km-wide vertical zone beneath the surface trace of the San Andreas is characterized by its almost complete lack of seismicity. The compressional deformation is consistent with the young, high topography of the Santa Cruz Mountains/Coast Ranges as the San Andreas fault makes a broad restraining left bend (˜10°) through the southernmost peninsula. A zone of seismic quiescence ˜15 km long separates this compressional zone to the south from a zone of combined normal-faulting and strike-slip-faulting focal mechanisms (including a ML = 5.3 earthquake in 1957) on the northernmost peninsula and offshore on the Golden Gate platform. Both linear pseudogravity gradients, calculated from the aeromagnetic data, and seismic reflection data indicate that the San Andreas fault makes an abrupt ˜3-km right step less than 5 km offshore in this northern zone. A similar right-stepping (dilatational) geometry is also observed for the subparallel San Gregorio fault offshore. Persistent seismicity and extensional tectonism occur within the San Andreas

  14. North Atlantic Meridional Overturning Circulation (AMOC) and Abrupt Climate Change through the Last Glaciation

    NASA Astrophysics Data System (ADS)

    Henry, G., III; McManus, J. F.; Curry, W. B.; Keigwin, L. D.; Giosan, L.

    2014-12-01

    The climate of the glacial North Atlantic was punctuated by catastrophic discharges of icebergs (Heinrich events), as well as by more mysterious, abrupt warming events associated with Dansgaard-Oeschger oscillations. These events are suspected to be related to changes in AMOC and its influence on heat transport and the regional and global heat budget. Investigation of these rapid oscillations is often limited by the resolution of sediment records. High accumulation rates at our study site (33.69°N, 57.58°W, 4583m water depth) on the Bermuda Rise allow improved resolution by one to two orders of magnitude. Cores CDH19 (38.81m) and CDH13 (36.70m), were recovered during KNR191, the initial deployment of the RV Knorr's long coring system developed at the Woods Hole Oceanographic Institution with support from the NSF. These cores contain high quality sediment sections that allow high resolution studies extending through the last glacial cycle at a key location for monitoring past oceanographic and climatic variability. Here we present detailed multi-proxy data from Bermuda Rise sediments reflecting deep ocean chemistry and dynamics of the last glaciation, and combine them with published data to produce a continuous, high resolution record spanning the last 70,000 years. CaCO3 burial fluxes, foraminifera stable isotopes, and sedimentary uranium-series disequilibria (including seawater-derived 231Pa /230Th), display coherent, complementary variability throughout the last glaciation. Glacial values in each proxy are consistent with reduced ventilation and overturning compared to the Holocene, with intervals that indicate substantial millennial reductions in each, and others when they briefly approach Holocene levels. In multiple instances, particularly spanning interstadials eight through twelve (IS8-IS12) our results are consistent with an abrupt, subcentennial acceleration in the export of excess 231Pa from the North Atlantic during stadial-interstadial transitions

  15. Abrupt along-strike change in tectonic style: San Andreas fault zone, San Francisco Peninsula

    USGS Publications Warehouse

    Zoback, M.L.; Jachens, R.C.; Olson, J.A.

    1999-01-01

    Seismicity and high-resolution aeromagnetic data are used to define an abrupt change from compressional to extensional tectonism within a 10- to 15-km-wide zone along the San Andreas fault on the San Francisco Peninsula and offshore from the Golden Gate. This 100-km-long section of the San Andreas fault includes the hypocenter of the Mw = 7.8 1906 San Francisco earthquake as well as the highest level of persistent microseismicity along that ???470-km-long rupture. We define two distinct zones of deformation along this stretch of the fault using well-constrained relocations of all post-1969 earthquakes based a joint one-dimensional velocity/hypocenter inversion and a redetermination of focal mechanisms. The southern zone is characterized by thrust- and reverse-faulting focal mechanisms with NE trending P axes that indicate "fault-normal" compression in 7- to 10-km-wide zones of deformation on both sides of the San Andreas fault. A 1- to 2-km-wide vertical zone beneath the surface trace of the San Andreas is characterized by its almost complete lack of seismicity. The compressional deformation is consistent with the young, high topography of the Santa Cruz Mountains/Coast Ranges as the San Andreas fault makes a broad restraining left bend (???10??) through the southernmost peninsula. A zone of seismic quiescence ???15 km long separates this compressional zone to the south from a zone of combined normal-faulting and strike-slip-faulting focal mechanisms (including a ML = 5.3 earthquake in 1957) on the northernmost peninsula and offshore on the Golden Gate platform. Both linear pseudo-gravity gradients, calculated from the aeromagnetic data, and seismic reflection data indicate that the San Andreas fault makes an abrupt ???3-km right step less than 5 km offshore in this northern zone. A similar right-stepping (dilatational) geometry is also observed for the subparallel San Gregorio fault offshore. Persistent seismicity and extensional tectonism occur within the San

  16. Periodicities, Trends and Abrupt Changes in the Vegetation Phenology of South Asia (Invited)

    NASA Astrophysics Data System (ADS)

    Small, C.; Mondal, P.; Jain, M.; Galford, G. L.; DeFries, R. S.

    2013-12-01

    and seasonal phases of single, double and triple cropped areas. The decadal trend EOF and year to year changes in the temporal feature space quantify inter-annual changes - both abrupt and progressive. We use multi-temporal Landsat imagery to vicariously validate inter-annual changes and infer their causes. The dominance of purely periodic phenology is much greater in S. Asia than found in similar analyses of agricultural areas of W. Africa, E. China or S. America. Despite the dominance of purely periodic phenology, inter-annual changes show increasing vegetation abundance in 2 to 3 times as much land area as comparable magnitude of decreasing abundance. Vicarious validation shows most increases as agricultural expansion and intensification while most abrupt decreases are related to channel migration on the Indus, Ganges and Brahmaputra rivers.

  17. Impact of Climate and Fires on Abrupt Permafrost Thaw in Alaskan Tundra

    NASA Astrophysics Data System (ADS)

    Chipman, M. L.; Reents, C.; Greenberg, J. A.; Hu, F.

    2015-12-01

    Thermo-erosion from abrupt permafrost thaw is a key pulse disturbance in the Arctic that may impact the global carbon cycle. Abrupt thaw can occur when the permafrost active layer expands in response to climate warming and/or increased wildfire activity. Understanding these drivers of thermo-erosion is necessary to anticipate feedbacks in the Arctic, where summer temperature and fire frequency are predicted to increase. We examine modern and late-Holocene thermo-erosion in high-fire (Noatak) and low-fire (North Slope) tundra ecoregions of Alaska using a combination of remote-sensing and paleo-records. Lakes with active thaw features were identified through Landsat-7 image classification and time-series analysis based on observed 0.52-0.60 μm reflectance peaks following slump formation. We identified 1067 and 1705 lakes with active features between CE 2000-2012 in the Noatak and North Slope ecoregions, respectively. The density of features was higher in the highly flammable Noatak (0.04 versus 0.01 features km-2, respectively), suggesting that warmer climate and/or fires likely promote high thermo-erosional activity at present. To assess modern signals of thermo-erosion and identify past events, we analyzed soil profiles and lake-sediment cores from both ecoregions using X-ray fluorescence. The ratios of Ca:K and Ca:Sr increased with depth in permafrost soils, were higher in soils from younger versus older slump surfaces, and were significantly correlated with the ratio of carbonate to feldspar and clay minerals in lake sediments (r=0.96 and 0.93, P<0.0001, n=15). We interpret past increases in Ca:K, Ca:Sr, and δ13C as enhanced weathering of carbonate-rich permafrost soils associated with thermo-erosion. At the North Slope site, we identified ten episodes of thermoerosion over the past 6000 years and found strong correspondence to summer temperature trends. Events were more frequent at the Noatak site, where 15 thermo-erosional episodes and 26 fires occurred over

  18. Abrupt climate changes and its oscillations in solar-terrestrial data

    NASA Astrophysics Data System (ADS)

    Kuznetsova, T.

    2003-04-01

    Time series of different solar-terrestrial data (on solar activity, geomagnetic field variations, Be-10, C-14, anomaly of global surface temperature,) are analysed by a method of non-linear spectral analysis (named by the MGM method) to detect time intervals of appearance of non-stationary oscillations of large amplitude and times of abrupt changes of their oscillation regime. Analysis shows that the most power cycles of the calculated spectra can be interpreted by periods (and overtones) of astronomical origin. The powerest non-stationary (with varying phase and amplitude) sinusoid at mean period T~2230 yr. (and its overtones), reflecting oscillations of non-dipole part of the geomagnetic field in C14 data and variations of long-term solar activity), is connected with climate variability and its abrupt changes. Derived regularities in behaviour of this cycle allow forecasting the tendency of climate changes in the future. Analysis of different studies shows that this cycle was detected in many geophysical data (governed by different physical mechanisms). It is shown that the time intervals of regime change of oscillations of the 2230-year cycle is reflected in all geophysical data synchro. It is generally recognized that climate regime shifts are connected with sudden changes of other geophysical systems although these systems are controlled by different physical mechanisms. However, this speed and the global synchronicity of climate changes are the major problems in understanding links between the Milankovich forcing of astronomical origin and climate data. It is possible to separate in orbital motion of each celestial body non-perturbed (Kepler's) part and perturbed one. The non-perturbed part of tide force characterizes non-evolving orbital motion (analogous to normal part of geophysical fields, for instance, gravitational and geomagnetic); respectively, perturbed part of tide force characterizes evolving orbital motion (analogous of anomalous part that can be

  19. Abrupt shifts in the fish community of the hydrologically variable upper estuary of the Swan River

    NASA Astrophysics Data System (ADS)

    Kanandjembo, A. N.; Potter, I. C.; Platell, M. E.

    2001-09-01

    Fish were sampled in nearshore, shallow waters (<1·5 m deep) and offshore, deeper waters (2·5-5 m) of the saline lower reaches of the Swan and Canning Rivers, which collectively represent the upper Swan-Canning Estuary, by using seine and gill nets, respectively, in each season between winter 1995 and autumn 1997. Seventeen of the 34 fish species caught during the study spawn in the upper estuaries. These species, which include the semi-anadromous Nematalosa vlaminghi, comprised 50·0% of the number of species and 88·8% of the number of fish in shallow waters and 43·8 and 89·9%, respectively, of those in deeper waters. The two most abundant species in shallow waters, Engraulis australis and N. vlaminghi, contributed 36·0 and 19·6%, respectively, to the total numbers of fish in those waters, and the latter species comprised nearly 50% of the catch in deeper waters. During winter, when freshwater discharge increased sharply and salinities declined precipitously, the number of species and abundance of fish in shallow and deeper waters were generally at their lowest and the species composition was the most discrete. This reflected the downstream movement out of the upper estuary of substantial numbers of individuals of species such as N. vlaminghi, Acanthopagrus butcheri, Amniataba caudavittata, Atherinomorus ogilbyi, Atherinosoma elongata and Craterocephalus mugiloides and the upstream movement into the upper estuary of juvenile Mugil cephalus. The overall fish fauna then changed quite abruptly in spring, when large N. vlaminghi, A. butcheri and A. caudavittata became abundant as they migrated into the upper estuary where they then spawned. During summer and autumn, the fauna in the shallows then changed more gradually through, inter alia, the recruitment of juvenile abrupt change in the fish community in winter contrasts with the

  20. Abrupt reflow enhances cytokine-induced proinflammatory activation of endothelial cells during simulated shock and resuscitation.

    PubMed

    Li, Ranran; Zijlstra, Jan G; Kamps, Jan A A M; van Meurs, Matijs; Molema, Grietje

    2014-10-01

    Circulatory shock and resuscitation are associated with systemic hemodynamic changes, which may contribute to the development of MODS (multiple organ dysfunction syndrome). In this study, we used an in vitro flow system to simulate the consecutive changes in blood flow as occurring during hemorrhagic shock and resuscitation in vivo. We examined the kinetic responses of different endothelial genes in human umbilical vein endothelial cells preconditioned to 20 dyne/cm unidirectional laminar shear stress for 48 h to flow cessation and abrupt reflow, respectively, as well as the effect of flow cessation and reflow on tumor necrosis factor-α (TNF-α)-induced endothelial proinflammatory activation. Endothelial CD31 and VE-cadherin were not affected by the changes in flow in the absence or presence of TNF-α. The messenger RNA levels of proinflammatory molecules E-selectin, VCAM-1 (vascular cell adhesion molecule 1), and IL-8 (interleukin 8) were significantly induced by flow cessation respectively acute reflow, whereas ICAM-1 (intercellular adhesion molecule 1) was downregulated on flow cessation and induced by subsequent acute reflow. Flow cessation also affected the Ang/Tie2 (Angiopoietin/Tie2 receptor tyrosine kinase) system by downregulating Tie2 and inducing its endothelial ligand Ang2, an effect that was further extended on acute reflow. Furthermore, the induction of proinflammatory adhesion molecules by TNF-α under flow cessation was significantly enhanced on subsequent acute reflow. This study demonstrated that flow alterations per se during shock and resuscitation contribute to endothelial activation and that these alterations interact with proinflammatory factors coexisting in vivo such as TNF-α. The abrupt reflow-related enhancement of cytokine-induced endothelial proinflammatory activation supports the concept that sudden regain of flow during resuscitation has an aggravating effect on endothelial activation, which may play a significant role in vascular

  1. Abrupt pre-Bølling-Allerød warming and circulation changes in the deep ocean.

    PubMed

    Thiagarajan, Nivedita; Subhas, Adam V; Southon, John R; Eiler, John M; Adkins, Jess F

    2014-07-01

    Several large and rapid changes in atmospheric temperature and the partial pressure of carbon dioxide in the atmosphere--probably linked to changes in deep ocean circulation--occurred during the last deglaciation. The abrupt temperature rise in the Northern Hemisphere and the restart of the Atlantic meridional overturning circulation at the start of the Bølling-Allerød interstadial, 14,700 years ago, are among the most dramatic deglacial events, but their underlying physical causes are not known. Here we show that the release of heat from warm waters in the deep North Atlantic Ocean probably triggered the Bølling-Allerød warming and reinvigoration of the Atlantic meridional overturning circulation. Our results are based on coupled radiocarbon and uranium-series dates, along with clumped isotope temperature estimates, from water column profiles of fossil deep-sea corals in a limited area of the western North Atlantic. We find that during Heinrich stadial 1 (the cool period immediately before the Bølling-Allerød interstadial), the deep ocean was about three degrees Celsius warmer than shallower waters above. This reversal of the ocean's usual thermal stratification pre-dates the Bølling-Allerød warming and must have been associated with increased salinity at depth to preserve the static stability of the water column. The depleted radiocarbon content of the warm and salty water mass implies a long-term disconnect from rapid surface exchanges, and, although uncertainties remain, is most consistent with a Southern Ocean source. The Heinrich stadial 1 ocean profile is distinct from the modern water column, that for the Last Glacial Maximum and that for the Younger Dryas, suggesting that the patterns we observe are a unique feature of the deglacial climate system. Our observations indicate that the deep ocean influenced dramatic Northern Hemisphere warming by storing heat at depth that preconditioned the system for a subsequent abrupt overturning event during the

  2. A ``triple sea-ice state'' mechanism for the abrupt warming and synchronous ice sheet collapses during Heinrich events

    NASA Astrophysics Data System (ADS)

    Kaspi, Yohai; Sayag, Roiy; Tziperman, Eli

    2004-09-01

    Abrupt, switch-like, changes in sea ice cover are proposed as a mechanism for the large-amplitude abrupt warming that seemed to have occurred after each Heinrich event. Sea ice changes are also used to explain the colder-than-ambient glacial conditions around the time of the glacier discharge. The abrupt warming events occur in this mechanism, owing to rapid sea ice melting which warmed the atmosphere via the strong sea ice albedo and insulating feedbacks. Such abrupt sea ice changes can also account for the warming observed during Dansgaard-Oeschger events. The sea ice changes are caused by a weak (order of 5 Sv) response of the thermohaline circulation (THC) to glacier discharges. The main point of this work is therefore that sea ice may be thought of as a very effective amplifier of a weak THC variability, explaining the abrupt temperature changes over Greenland. Synchronous ice sheet collapses from different ice sheets around the North Atlantic, indicated by some proxy records, are shown to be possible via the weak coupling between the different ice sheets by the atmospheric temperature changes caused by the sea ice changes. This weak coupling can lead to a "nonlinear phase locking" of the different ice sheets which therefore discharge synchronously. It is shown that the phase locking may also lead to "precursor" glacier discharge events from smaller ice sheets before the Laurentide Ice Sheet discharges. The precursor events in this mechanism are the result rather than the cause of the major glacier discharges from the Laurentide Ice Sheet.

  3. Generalized Pump-restriction Theorem

    SciTech Connect

    Sinitsyn, Nikolai A; Chernyak, Vladimir Y

    2008-01-01

    We formulate conditions under which periodic modulations of parameters on a finite graph with stochastic transitions among its nodes do not lead to overall pump currents through any given link. Our theorem unifies previously known results with the new ones and provides a universal approach to explore futher restrictions on stochastic pump effect in non-adiabatically driven systems with detailed balance.

  4. A comparison of two methods for detecting abrupt changes in the variance of climatic time series

    NASA Astrophysics Data System (ADS)

    Rodionov, Sergei N.

    2016-06-01

    Two methods for detecting abrupt shifts in the variance - Integrated Cumulative Sum of Squares (ICSS) and Sequential Regime Shift Detector (SRSD) - have been compared on both synthetic and observed time series. In Monte Carlo experiments, SRSD outperformed ICSS in the overwhelming majority of the modeled scenarios with different sequences of variance regimes. The SRSD advantage was particularly apparent in the case of outliers in the series. On the other hand, SRSD has more parameters to adjust than ICSS, which requires more experience from the user in order to select those parameters properly. Therefore, ICSS can serve as a good starting point of a regime shift analysis. When tested on climatic time series, in most cases both methods detected the same change points in the longer series (252-787 monthly values). The only exception was the Arctic Ocean sea surface temperature (SST) series, when ICSS found one extra change point that appeared to be spurious. As for the shorter time series (66-136 yearly values), ICSS failed to detect any change points even when the variance doubled or tripled from one regime to another. For these time series, SRSD is recommended. Interestingly, all the climatic time series tested, from the Arctic to the tropics, had one thing in common: the last shift detected in each of these series was toward a high-variance regime. This is consistent with other findings of increased climate variability in recent decades.

  5. Macrosegregation in Al-7Si alloy caused by abrupt cross-section change during directional solidification

    NASA Astrophysics Data System (ADS)

    Ghods, M.; Johnson, L.; Lauer, M.; Grugel, R. N.; Tewari, S. N.; Poirier, D. R.

    2016-09-01

    Hypoeutectic Al-7 wt .% Si alloys were directionally solidified vertically downward in cylindrical molds that incorporated an abrupt cross-section decrease (9.5 mm to 3.2 mm diameter) which, after 5 cm, reverted back to 9.5 mm diameter in a Bridgman furnace; two constant growth speeds and thermal gradients were investigated. Thermosolutal convection and cross-section-change-induced shrinkage flow effects on macrosegregation were investigated. Dendrite clustering and extensive radial macrosegregation was seen, particularly in the larger cross-sections, before contraction and after expansion, this more evident at the lower growth speed. This alloy shows positive longitudinal macrosegregation near cross-section decrease followed by negative macrosegregation right after it; the extent of macrosegregation, however, decreases with increasing growth speed. Primary dendrite steepling intensified as solidification proceeded into the narrower section and negative longitudinal macrosegregation was seen on the re-entrant shelves at expansion. A two-dimensional model accounting for both shrinkage and thermo-solutal convection was used to simulate solidification and the resulting mushy-zone steepling and macrosegregation. The experimentally observed longitudinal and radial macrosegregation associated with the cross-section changes during directional solidification of an Al-7Si alloy is well captured by the numerical simulations.

  6. Abrupt decadal-to-centennial hydroclimate changes in the Mediterranean region since the mid-Holocene

    NASA Astrophysics Data System (ADS)

    Hu, Hsun-Ming; Shen, Chuan-Chou; Jiang, Xiuyang; Wang, Yongjin; Mii, Horng-Sheng; Michel, Véronique

    2016-04-01

    A series of severe drought events in the Mediterranean region over the past two decades has posed a threat on both human society and biosystem. Holocene hydrological dynamics can offer valuable clues for understanding future climate and making proper adaption strategy. Here, we present a decadal-resolved stalagmite record documenting various hydroclimatic fluctuations in the north central Mediterranean region since the middle Holocene. The stalagmite δ18O sequence shows dramatic instability, characterized by abrupt shifts between dry and wet conditions <50 years. The timing of regional culture demises, such as the Hittite Kingdom, Mycenaean Greece, Akkadian Empire, Egyptian Old Kingdom, and Uruk, occurred during the drought events, suggesting an important role of climate impact on human civilization. The unstable hydroclimate evolution is related to transferred North Atlantic Oscillation states. Rate of rapid transfer of precipitation patterns, which can be pin-pointed by our good chronology, improves the prediction to future climate changes in North Atlantic region. We also found that a strong correlation between this stalagmite δ18O and sea surface temperatures especially in Pacific Ocean. This agreement suggests a distant interregional climate teleconnection.

  7. A steep-slope transistor based on abrupt electronic phase transition.

    PubMed

    Shukla, Nikhil; Thathachary, Arun V; Agrawal, Ashish; Paik, Hanjong; Aziz, Ahmedullah; Schlom, Darrell G; Gupta, Sumeet Kumar; Engel-Herbert, Roman; Datta, Suman

    2015-08-07

    Collective interactions in functional materials can enable novel macroscopic properties like insulator-to-metal transitions. While implementing such materials into field-effect-transistor technology can potentially augment current state-of-the-art devices by providing unique routes to overcome their conventional limits, attempts to harness the insulator-to-metal transition for high-performance transistors have experienced little success. Here, we demonstrate a pathway for harnessing the abrupt resistivity transformation across the insulator-to-metal transition in vanadium dioxide (VO2), to design a hybrid-phase-transition field-effect transistor that exhibits gate controlled steep ('sub-kT/q') and reversible switching at room temperature. The transistor design, wherein VO2 is implemented in series with the field-effect transistor's source rather than into the channel, exploits negative differential resistance induced across the VO2 to create an internal amplifier that facilitates enhanced performance over a conventional field-effect transistor. Our approach enables low-voltage complementary n-type and p-type transistor operation as demonstrated here, and is applicable to other insulator-to-metal transition materials, offering tantalizing possibilities for energy-efficient logic and memory applications.

  8. Pacific origin of the abrupt increase in Indian Ocean heat content during the warming hiatus

    NASA Astrophysics Data System (ADS)

    Lee, Sang-Ki; Park, Wonsun; Baringer, Molly O.; Gordon, Arnold L.; Huber, Bruce; Liu, Yanyun

    2015-06-01

    Global mean surface warming has stalled since the end of the twentieth century, but the net radiation imbalance at the top of the atmosphere continues to suggest an increasingly warming planet. This apparent contradiction has been reconciled by an anomalous heat flux into the ocean, induced by a shift towards a La Niña-like state with cold sea surface temperatures in the eastern tropical Pacific over the past decade or so. A significant portion of the heat missing from the atmosphere is therefore expected to be stored in the Pacific Ocean. However, in situ hydrographic records indicate that Pacific Ocean heat content has been decreasing. Here, we analyse observations along with simulations from a global ocean-sea ice model to track the pathway of heat. We find that the enhanced heat uptake by the Pacific Ocean has been compensated by an increased heat transport from the Pacific Ocean to the Indian Ocean, carried by the Indonesian throughflow. As a result, Indian Ocean heat content has increased abruptly, which accounts for more than 70% of the global ocean heat gain in the upper 700 m during the past decade. We conclude that the Indian Ocean has become increasingly important in modulating global climate variability.

  9. On the abrupt growth dynamics of nonlinear resistive tearing mode and the viscosity effects

    SciTech Connect

    Ali, A.; Li, Jiquan; Kishimoto, Y.

    2014-05-15

    The nonlinear evolution of the resistive tearing mode exhibits an abrupt growth after an X-point collapse once the magnetic island exceeds a certain critical width Δ′w{sub c} for large instability parameter Δ′, leading to a current sheet formation [N. F. Loureiro et al., Phys. Rev. Lett. 95, 235003 (2005)]. In this work, we investigate the underlying mechanism of the X-point collapse as well as the current sheet formation including the viscosity effects, based on a secondary instability analysis. The secondary instability is excited due to the quasilinear current modification by the zonal current. In particular, it is identified that the current peaking effect is plausibly responsible for the onset of the X-point collapse and the current sheet formation, leading to the explosive growth of reconnected flux. In the presence of finite viscosity, the Δ′w{sub c} scaling with the resistivity gets modified. A transition behavior is revealed at P{sub r}≈1 for the viscosity dependence of Δ′w{sub c} and the linear tearing instability. However, the explosive growth seems to be independent of the viscosity in the magnetic Prandtl number P{sub r}<1 regime, while large viscosity plays a strong dissipation role.

  10. Slowing down of North Pacific climate variability and its implications for abrupt ecosystem change.

    PubMed

    Boulton, Chris A; Lenton, Timothy M

    2015-09-15

    Marine ecosystems are sensitive to stochastic environmental variability, with higher-amplitude, lower-frequency--i.e., "redder"--variability posing a greater threat of triggering large ecosystem changes. Here we show that fluctuations in the Pacific Decadal Oscillation (PDO) index have slowed down markedly over the observational record (1900-present), as indicated by a robust increase in autocorrelation. This "reddening" of the spectrum of climate variability is also found in regionally averaged North Pacific sea surface temperatures (SSTs), and can be at least partly explained by observed deepening of the ocean mixed layer. The progressive reddening of North Pacific climate variability has important implications for marine ecosystems. Ecosystem variables that respond linearly to climate forcing will have become prone to much larger variations over the observational record, whereas ecosystem variables that respond nonlinearly to climate forcing will have become prone to more frequent "regime shifts." Thus, slowing down of North Pacific climate variability can help explain the large magnitude and potentially the quick succession of well-known abrupt changes in North Pacific ecosystems in 1977 and 1989. When looking ahead, despite model limitations in simulating mixed layer depth (MLD) in the North Pacific, global warming is robustly expected to decrease MLD. This could potentially reverse the observed trend of slowing down of North Pacific climate variability and its effects on marine ecosystems.

  11. Abrupt onset and prolongation of aragonite undersaturation events in the Southern Ocean

    NASA Astrophysics Data System (ADS)

    Hauri, Claudine; Friedrich, Tobias; Timmermann, Axel

    2016-02-01

    Ocean acidification may lead to seasonal aragonite undersaturation in surface waters of the Southern Ocean as early as 2030 (ref. ). These conditions are harmful to key organisms such as pteropods, which contribute significantly to the pelagic foodweb and carbon export fluxes in this region. Although the severity of ocean acidification impacts is mainly determined by the duration, intensity and spatial extent of aragonite undersaturation events, little is known about the nature of these events, their evolving attributes and the timing of their onset in the Southern Ocean. Using an ensemble of ten Earth system models, we show that starting around 2030, aragonite undersaturation events will spread rapidly, affecting ~30% of Southern Ocean surface waters by 2060 and >70% by 2100, including the Patagonian Shelf. On their onset, the duration of these events will increase abruptly from 1 month to 6 months per year in less than 20 years in >75% of the area affected by end-of-century aragonite undersaturation. This is likely to decrease the ability of organisms to adapt to a quickly evolving environment. The rapid equatorward progression of surface aragonite undersaturation can be explained by the uptake of anthropogenic CO2, whereas climate-driven physical or biological changes will play a minor role.

  12. Abrupt state change of river water quality (turbidity): Effect of extreme rainfalls and typhoons.

    PubMed

    Lee, Chih-Sheng; Lee, Yi-Chao; Chiang, Hui-Min

    2016-07-01

    River turbidity is of dynamic nature, and its stable state is significantly changed during the period of heavy rainfall events. The frequent occurrence of typhoons in Taiwan has caused serious problems in drinking water treatment due to extremely high turbidity. The aim of the present study is to evaluate impact of typhoons on river turbidity. The statistical methods used included analyses of paired annual mean and standard deviation, frequency distribution, and moving standard deviation, skewness, and autocorrelation; all clearly indicating significant state changes of river turbidity. Typhoon Morakot of 2009 (recorded high rainfall over 2000mm in three days, responsible for significant disaster in southern Taiwan) is assumed as a major initiated event leading to critical state change. In addition, increasing rate of turbidity in rainfall events is highly and positively correlated with rainfall intensity both for pre- and post-Morakot periods. Daily turbidity is also well correlated with daily flow rate for all the eleven events evaluated. That implies potential prediction of river turbidity by river flow rate during rainfall and typhoon events. Based on analysis of stable state changes, more effective regulations for better basin management including soil-water conservation in watershed are necessary. Furthermore, municipal and industrial water treatment plants need to prepare and ensure the adequate operation of water treatment with high raw water turbidity (e.g., >2000NTU). Finally, methodology used in the present of this study can be applied to other environmental problems with abrupt state changes.

  13. Slowing down of North Pacific climate variability and its implications for abrupt ecosystem change

    PubMed Central

    Boulton, Chris A.; Lenton, Timothy M.

    2015-01-01

    Marine ecosystems are sensitive to stochastic environmental variability, with higher-amplitude, lower-frequency––i.e., “redder”––variability posing a greater threat of triggering large ecosystem changes. Here we show that fluctuations in the Pacific Decadal Oscillation (PDO) index have slowed down markedly over the observational record (1900–present), as indicated by a robust increase in autocorrelation. This “reddening” of the spectrum of climate variability is also found in regionally averaged North Pacific sea surface temperatures (SSTs), and can be at least partly explained by observed deepening of the ocean mixed layer. The progressive reddening of North Pacific climate variability has important implications for marine ecosystems. Ecosystem variables that respond linearly to climate forcing will have become prone to much larger variations over the observational record, whereas ecosystem variables that respond nonlinearly to climate forcing will have become prone to more frequent “regime shifts.” Thus, slowing down of North Pacific climate variability can help explain the large magnitude and potentially the quick succession of well-known abrupt changes in North Pacific ecosystems in 1977 and 1989. When looking ahead, despite model limitations in simulating mixed layer depth (MLD) in the North Pacific, global warming is robustly expected to decrease MLD. This could potentially reverse the observed trend of slowing down of North Pacific climate variability and its effects on marine ecosystems. PMID:26324900

  14. Abrupt Emergence of a Single Dominant Multidrug-Resistant Strain of Escherichia coli

    PubMed Central

    Johnson, James R.; Tchesnokova, Veronika; Johnston, Brian; Clabots, Connie; Roberts, Pacita L.; Billig, Mariya; Riddell, Kim; Rogers, Peggy; Qin, Xuan; Butler-Wu, Susan; Price, Lance B.; Aziz, Maliha; Nicolas-Chanoine, Marie-Hélène; DebRoy, Chitrita; Robicsek, Ari; Hansen, Glen; Urban, Carl; Platell, Joanne; Trott, Darren J.; Zhanel, George; Weissman, Scott J.; Cookson, Brad T.; Fang, Ferric C.; Limaye, Ajit P.; Scholes, Delia; Chattopadhyay, Sujay; Hooper, David C.; Sokurenko, Evgeni V.

    2013-01-01

    Background. Fluoroquinolone-resistant Escherichia coli are increasingly prevalent. Their clonal origins—potentially critical for control efforts—remain undefined. Methods. Antimicrobial resistance profiles and fine clonal structure were determined for 236 diverse-source historical (1967–2009) E. coli isolates representing sequence type ST131 and 853 recent (2010–2011) consecutive E. coli isolates from 5 clinical laboratories in Seattle, Washington, and Minneapolis, Minnesota. Clonal structure was resolved based on fimH sequence (fimbrial adhesin gene: H subclone assignments), multilocus sequence typing, gyrA and parC sequence (fluoroquinolone resistance-determining loci), and pulsed-field gel electrophoresis. Results. Of the recent fluoroquinolone-resistant clinical isolates, 52% represented a single ST131 subclonal lineage, H30, which expanded abruptly after 2000. This subclone had a unique and conserved gyrA/parC allele combination, supporting its tight clonality. Unlike other ST131 subclones, H30 was significantly associated with fluoroquinolone resistance and was the most prevalent subclone among current E. coli clinical isolates, overall (10.4%) and within every resistance category (11%–52%). Conclusions. Most current fluoroquinolone-resistant E. coli clinical isolates, and the largest share of multidrug-resistant isolates, represent a highly clonal subgroup that likely originated from a single rapidly expanded and disseminated ST131 strain. Focused attention to this strain will be required to control the fluoroquinolone and multidrug-resistant E. coli epidemic. PMID:23288927

  15. Peak and Persistent Excess of Genetic Diversity Following an Abrupt Migration Increase

    PubMed Central

    Alcala, Nicolas; Streit, Daniela; Goudet, Jérôme; Vuilleumier, Séverine

    2013-01-01

    Genetic diversity is essential for population survival and adaptation to changing environments. Demographic processes (e.g., bottleneck and expansion) and spatial structure (e.g., migration, number, and size of populations) are known to shape the patterns of the genetic diversity of populations. However, the impact of temporal changes in migration on genetic diversity has seldom been considered, although such events might be the norm. Indeed, during the millions of years of a species’ lifetime, repeated isolation and reconnection of populations occur. Geological and climatic events alternately isolate and reconnect habitats. We analytically document the dynamics of genetic diversity after an abrupt change in migration given the mutation rate and the number and sizes of the populations. We demonstrate that during transient dynamics, genetic diversity can reach unexpectedly high values that can be maintained over thousands of generations. We discuss the consequences of such processes for the evolution of species based on standing genetic variation and how they can affect the reconstruction of a population’s demographic and evolutionary history from genetic data. Our results also provide guidelines for the use of genetic data for the conservation of natural populations. PMID:23307901

  16. Linear sea-level response to abrupt ocean warming of major West Antarctic ice basin

    NASA Astrophysics Data System (ADS)

    Mengel, M.; Feldmann, J.; Levermann, A.

    2016-01-01

    Antarctica's contribution to global sea-level rise has recently been increasing. Whether its ice discharge will become unstable and decouple from anthropogenic forcing or increase linearly with the warming of the surrounding ocean is of fundamental importance. Under unabated greenhouse-gas emissions, ocean models indicate an abrupt intrusion of warm circumpolar deep water into the cavity below West Antarctica's Filchner-Ronne ice shelf within the next two centuries. The ice basin's retrograde bed slope would allow for an unstable ice-sheet retreat, but the buttressing of the large ice shelf and the narrow glacier troughs tend to inhibit such instability. It is unclear whether future ice loss will be dominated by ice instability or anthropogenic forcing. Here we show in regional and continental-scale ice-sheet simulations, which are capable of resolving unstable grounding-line retreat, that the sea-level response of the Filchner-Ronne ice basin is not dominated by ice instability and follows the strength of the forcing quasi-linearly. We find that the ice loss reduces after each pulse of projected warm water intrusion. The long-term sea-level contribution is approximately proportional to the total shelf-ice melt. Although the local instabilities might dominate the ice loss for weak oceanic warming, we find that the upper limit of ice discharge from the region is determined by the forcing and not by the marine ice-sheet instability.

  17. Abrupt change of sedimentation rate recorded in lacustrine sediment from coastal lakes, Nankai subduction zone

    NASA Astrophysics Data System (ADS)

    Matsuoka, H.; Okamura, M.

    2014-12-01

    Nankai earthquakes are plate-boundary earthquakes associated with the Nankai subduction zone that have occurred repeatedly during historic times. In order to reveal pre-historical evidence of Nankai earthquakes, we investigated lacustrine sediments of small lakes on the coastal area of Shikoku Island, along the Nankai Trough. We studied over 150 piston- and vibro- core samples from 20 small lakes in this region, and found out many sedimentary evidences of tsunami events. Only three small lakes, Tadasu-Ike, Kaniga-Ike and Kamoda- Ike have over 5000 yaers sedimentary record. Tadasu-Ike and Kaniga-Ike have kept ten and several times tsunami events, on the other hand only one event preserved in though 6500 years sediments of Kamoda- Ike. These three small lakes have characteristic sedimentary conditions. Abrupt change of sedimentation rate was recorded 1-2 times through 5000-7000 years their history. This change was thought to reflect subsidence of the surrounding area. Co-seismic subsidence and gradual uplift during inter-seismic period are well known in this region. Several thousand-year cycle subsidences are assumed in addition to subsidences accompanied with 100-year cycle earthquakes.

  18. Abrupt Climate Change in the Arctic (and Beyond): An Update (Invited)

    NASA Astrophysics Data System (ADS)

    Alley, R. B.

    2013-12-01

    Our understanding of future Arctic change is informed by the history of past changes, which often have been both large and abrupt. The well-known ice-age events such as the Younger Dryas show how sea-ice changes can amplify forcing to produce very large responses, with wintertime sea ice especially important. These changes are increasingly seen to have played a central role in the ice-age cycling through their global impact on CO2 storage in the deep ocean. The Heinrich events reveal processes of ice-sheet/ocean interaction, some of which are being played out in Greenland and Antarctica now, and which may have large future effects on sea-level rise. The paleoclimatic record plus physical understanding greatly reduce the worst worries about instabilities from methane stored in cold places, but tend to support a role in amplifying future warming. Overall, the very large impacts of past Arctic changes, and the likelihood that future changes under business-as-usual fossil-fuel emissions will be unprecedented in combined size and speed, raise important questions.

  19. Response of Airborne Mycoplasma pneumoniae to Abrupt Changes in Relative Humidity

    PubMed Central

    Hatch, M. T.; Wright, D. N.; Bailey, G. D.

    1970-01-01

    The effect of an abrupt change in the relative humidity on the viability of airborne Mycoplasma pneumoniae has been examined. When the microbial aerosols were permitted to equilibrate in air held at either low or high humidities and were then subjected to a sudden shift to a mid-range humidity, a significant loss (>90%) of the colony-forming units per liter of aerosol occurred within 8 min. In contrast, a change in the relative humidity of more than 18% in either direction from a lethal mid-range humidity noticeably decreased the rate of biological decay. Double humidity shifts (i.e., from dry to a mid-range level and then to a high humidity range) were very detrimental, with very few survivors after 8 min. These results indicate that the biological stability of airborne M. pneumoniae may be easily modified by a sudden change in the relative humidity, such as occurs in natural atmospheres. This increased sensitivity brought about by producing changes in relative humidity through the lethal humidity range may provide a method whereby the control of these organisms in naturally contaminated indoor air environments may be eventually achieved. PMID:5437301

  20. The Effects of Abrupt Wind Shears in the Solar Wind on the Earth's Magnetosphere

    NASA Astrophysics Data System (ADS)

    Borovsky, J.; Boudouridis, A.; Birn, J.; Denton, M.

    2014-12-01

    The solar wind is filled sudden velocity shears. The shears take the form of vorticity layers co-located with current sheets. The velocity vector makes its change in a few seconds. For shear layers with vector velocity changes greater than 50 km/s, an average of 12 shear layers pass the Earth per day. Global magnetospheric MHD simulations with four different simulation codes have been performed at the Community Coordinated Modeling Center (CCMC) to examine the reaction of the Earth to the solar-wind velocity shears. All 4 simulation codes predict comet-like disconnections of the magnetotail, the magnetosheath, and the bow shock on the flanks as a shear layer passes the Earth. The simulation codes also predict sudden changes in the cross-polar-cap potential and ionospheric Joule dissipation as the shear layers pass the Earth. A data-analysis research effort is underway to look for signatures of the Earth's reaction to abrupt wind shear events; preliminary results of that effort will be discussed.

  1. Clean Nanotube Unzipping by Abrupt Thermal Expansion of Molecular Nitrogen: Graphene Nanoribbons with Atomically Smooth Edges

    SciTech Connect

    Sumpter, Bobby G; Meunier, Vincent; Terrones, M.; Endo, M; Munoz-Sandoval, Emilio; Kim, Y A; Morelos-Bomez, Aaron; Vega-Diaz, Sofia

    2012-01-01

    We report a novel physicochemical route to produce highly crystalline nitrogen-doped graphene nanoribbons. The technique consists of an abrupt N2 gas expansion within the hollow core of nitrogen-doped multiwalled carbon nanotubes (CNx-MWNTs) when exposed to a fast thermal shock. The multiwalled nanotube unzipping mechanism is rationalized using molecular dynamics and density functional theory simulations, which highlight the importance of open-ended nanotubes in promoting the efficient introduction of N2 molecules by capillary action within tubes and surface defects, thus triggering an efficient and atomically smooth unzipping. The so-produced nanoribbons could be few-layered (from graphene bilayer onward) and could exhibit both crystalline zigzag and armchair edges. In contrast to methods developed previously, our technique presents various advantages: (1) the tubes are not heavily oxidized; (2) the method yields sharp atomic edges within the resulting nanoribbons; (3) the technique could be scaled up for the bulk production of crystalline nanoribbons from available MWNT sources; and (4) this route could eventually be used to unzip other types of carbon nanotubes or intercalated layered materials such as BN, MoS2, WS2, etc.

  2. Gain control through divisive inhibition prevents abrupt transition to chaos in a neural mass model

    PubMed Central

    Papasavvas, Christoforos A.; Wang, Yujiang; Trevelyan, Andrew J.; Kaiser, Marcus

    2016-01-01

    Experimental results suggest that there are two distinct mechanisms of inhibition in cortical neuronal networks: subtractive and divisive inhibition. They modulate the input-output function of their target neurons either by increasing the input that is needed to reach maximum output or by reducing the gain and the value of maximum output itself, respectively. However, the role of these mechanisms on the dynamics of the network is poorly understood. We introduce a novel population model and numerically investigate the influence of divisive inhibition on network dynamics. Specifically, we focus on the transitions from a state of regular oscillations to a state of chaotic dynamics via period-doubling bifurcations. The model with divisive inhibition exhibits a universal transition rate to chaos (Feigenbaum behavior). In contrast, in an equivalent model without divisive inhibition, transition rates to chaos are not bounded by the universal constant (non-Feigenbaum behavior). This non-Feigenbaum behavior, when only subtractive inhibition is present, is linked to the interaction of bifurcation curves in the parameter space. Indeed, searching the parameter space showed that such interactions are impossible when divisive inhibition is included. Therefore, divisive inhibition prevents non-Feigenbaum behavior and, consequently, any abrupt transition to chaos. The results suggest that the divisive inhibition in neuronal networks could play a crucial role in keeping the states of order and chaos well separated and in preventing the onset of pathological neural dynamics. PMID:26465514

  3. A steep-slope transistor based on abrupt electronic phase transition

    PubMed Central

    Shukla, Nikhil; Thathachary, Arun V.; Agrawal, Ashish; Paik, Hanjong; Aziz, Ahmedullah; Schlom, Darrell G.; Gupta, Sumeet Kumar; Engel-Herbert, Roman; Datta, Suman

    2015-01-01

    Collective interactions in functional materials can enable novel macroscopic properties like insulator-to-metal transitions. While implementing such materials into field-effect-transistor technology can potentially augment current state-of-the-art devices by providing unique routes to overcome their conventional limits, attempts to harness the insulator-to-metal transition for high-performance transistors have experienced little success. Here, we demonstrate a pathway for harnessing the abrupt resistivity transformation across the insulator-to-metal transition in vanadium dioxide (VO2), to design a hybrid-phase-transition field-effect transistor that exhibits gate controlled steep (‘sub-kT/q') and reversible switching at room temperature. The transistor design, wherein VO2 is implemented in series with the field-effect transistor's source rather than into the channel, exploits negative differential resistance induced across the VO2 to create an internal amplifier that facilitates enhanced performance over a conventional field-effect transistor. Our approach enables low-voltage complementary n-type and p-type transistor operation as demonstrated here, and is applicable to other insulator-to-metal transition materials, offering tantalizing possibilities for energy-efficient logic and memory applications. PMID:26249212

  4. Gain control through divisive inhibition prevents abrupt transition to chaos in a neural mass model.

    PubMed

    Papasavvas, Christoforos A; Wang, Yujiang; Trevelyan, Andrew J; Kaiser, Marcus

    2015-09-01

    Experimental results suggest that there are two distinct mechanisms of inhibition in cortical neuronal networks: subtractive and divisive inhibition. They modulate the input-output function of their target neurons either by increasing the input that is needed to reach maximum output or by reducing the gain and the value of maximum output itself, respectively. However, the role of these mechanisms on the dynamics of the network is poorly understood. We introduce a novel population model and numerically investigate the influence of divisive inhibition on network dynamics. Specifically, we focus on the transitions from a state of regular oscillations to a state of chaotic dynamics via period-doubling bifurcations. The model with divisive inhibition exhibits a universal transition rate to chaos (Feigenbaum behavior). In contrast, in an equivalent model without divisive inhibition, transition rates to chaos are not bounded by the universal constant (non-Feigenbaum behavior). This non-Feigenbaum behavior, when only subtractive inhibition is present, is linked to the interaction of bifurcation curves in the parameter space. Indeed, searching the parameter space showed that such interactions are impossible when divisive inhibition is included. Therefore, divisive inhibition prevents non-Feigenbaum behavior and, consequently, any abrupt transition to chaos. The results suggest that the divisive inhibition in neuronal networks could play a crucial role in keeping the states of order and chaos well separated and in preventing the onset of pathological neural dynamics. PMID:26465514

  5. Abrupt current switching in graphene bilayer tunnel transistors enabled by van Hove singularities

    PubMed Central

    Alymov, Georgy; Vyurkov, Vladimir; Ryzhii, Victor; Svintsov, Dmitry

    2016-01-01

    In a continuous search for the energy-efficient electronic switches, a great attention is focused on tunnel field-effect transistors (TFETs) demonstrating an abrupt dependence of the source-drain current on the gate voltage. Among all TFETs, those based on one-dimensional (1D) semiconductors exhibit the steepest current switching due to the singular density of states near the band edges, though the current in 1D structures is pretty low. In this paper, we propose a TFET based on 2D graphene bilayer which demonstrates a record steep subthreshold slope enabled by van Hove singularities in the density of states near the edges of conduction and valence bands. Our simulations show the accessibility of 3.5 × 104 ON/OFF current ratio with 150 mV gate voltage swing, and a maximum subthreshold slope of (20 μV/dec)−1 just above the threshold. The high ON-state current of 0.8 mA/μm is enabled by a narrow (~0.3 eV) extrinsic band gap, while the smallness of the leakage current is due to an all-electrical doping of the source and drain contacts which suppresses the band tailing and trap-assisted tunneling. PMID:27098051

  6. Impact of abrupt deglacial climate change on tropical Atlantic subsurface temperatures.

    PubMed

    Schmidt, Matthew W; Chang, Ping; Hertzberg, Jennifer E; Them, Theodore R; Ji, Link; J, Link; Otto-Bliesner, Bette L

    2012-09-01

    Both instrumental data analyses and coupled ocean-atmosphere models indicate that Atlantic meridional overturning circulation (AMOC) variability is tightly linked to abrupt tropical North Atlantic (TNA) climate change through both atmospheric and oceanic processes. Although a slowdown of AMOC results in an atmospheric-induced surface cooling in the entire TNA, the subsurface experiences an even larger warming because of rapid reorganizations of ocean circulation patterns at intermediate water depths. Here, we reconstruct high-resolution temperature records using oxygen isotope values and Mg/Ca ratios in both surface- and subthermocline-dwelling planktonic foraminifera from a sediment core located in the TNA over the last 22 ky. Our results show significant changes in the vertical thermal gradient of the upper water column, with the warmest subsurface temperatures of the last deglacial transition corresponding to the onset of the Younger Dryas. Furthermore, we present new analyses of a climate model simulation forced with freshwater discharge into the North Atlantic under Last Glacial Maximum forcings and boundary conditions that reveal a maximum subsurface warming in the vicinity of the core site and a vertical thermal gradient change at the onset of AMOC weakening, consistent with the reconstructed record. Together, our proxy reconstructions and modeling results provide convincing evidence for a subsurface oceanic teleconnection linking high-latitude North Atlantic climate to the tropical Atlantic during periods of reduced AMOC across the last deglacial transition. PMID:22908256

  7. Abrupt state change of river water quality (turbidity): Effect of extreme rainfalls and typhoons.

    PubMed

    Lee, Chih-Sheng; Lee, Yi-Chao; Chiang, Hui-Min

    2016-07-01

    River turbidity is of dynamic nature, and its stable state is significantly changed during the period of heavy rainfall events. The frequent occurrence of typhoons in Taiwan has caused serious problems in drinking water treatment due to extremely high turbidity. The aim of the present study is to evaluate impact of typhoons on river turbidity. The statistical methods used included analyses of paired annual mean and standard deviation, frequency distribution, and moving standard deviation, skewness, and autocorrelation; all clearly indicating significant state changes of river turbidity. Typhoon Morakot of 2009 (recorded high rainfall over 2000mm in three days, responsible for significant disaster in southern Taiwan) is assumed as a major initiated event leading to critical state change. In addition, increasing rate of turbidity in rainfall events is highly and positively correlated with rainfall intensity both for pre- and post-Morakot periods. Daily turbidity is also well correlated with daily flow rate for all the eleven events evaluated. That implies potential prediction of river turbidity by river flow rate during rainfall and typhoon events. Based on analysis of stable state changes, more effective regulations for better basin management including soil-water conservation in watershed are necessary. Furthermore, municipal and industrial water treatment plants need to prepare and ensure the adequate operation of water treatment with high raw water turbidity (e.g., >2000NTU). Finally, methodology used in the present of this study can be applied to other environmental problems with abrupt state changes. PMID:26994797

  8. ABRUPT LONGITUDINAL MAGNETIC FIELD CHANGES AND ULTRAVIOLET EMISSIONS ACCOMPANYING SOLAR FLARES

    SciTech Connect

    Johnstone, B. M.; Petrie, G. J. D.; Sudol, J. J.

    2012-11-20

    We have used Transition Region and Coronal Explorer 1600 A images and Global Oscillation Network Group (GONG) magnetograms to compare ultraviolet (UV) emissions from the chromosphere to longitudinal magnetic field changes in the photosphere during four X-class solar flares. An abrupt, significant, and persistent change in the magnetic field occurred across more than 10 pixels in the GONG magnetograms for each flare. These magnetic changes lagged the GOES flare start times in all cases, showing that they were consequences and not causes of the flares. Ultraviolet emissions were spatially coincident with the field changes. The UV emissions tended to lag the GOES start times for the flares and led the changes in the magnetic field in all pixels except one. The UV emissions led the photospheric field changes by 4 minutes on average with the longest lead being 9 minutes; however, the UV emissions continued for tens of minutes, and more than an hour in some cases, after the field changes were complete. The observations are consistent with the picture in which an Alfven wave from the field reconnection site in the corona propagates field changes outward in all directions near the onset of the impulsive phase, including downward through the chromosphere and into the photosphere, causing the photospheric field changes, whereas the chromosphere emits in the UV in the form of flare kernels, ribbons, and sequential chromospheric brightenings during all phases of the flare.

  9. Abrupt current switching in graphene bilayer tunnel transistors enabled by van Hove singularities

    NASA Astrophysics Data System (ADS)

    Alymov, Georgy; Vyurkov, Vladimir; Ryzhii, Victor; Svintsov, Dmitry

    2016-04-01

    In a continuous search for the energy-efficient electronic switches, a great attention is focused on tunnel field-effect transistors (TFETs) demonstrating an abrupt dependence of the source-drain current on the gate voltage. Among all TFETs, those based on one-dimensional (1D) semiconductors exhibit the steepest current switching due to the singular density of states near the band edges, though the current in 1D structures is pretty low. In this paper, we propose a TFET based on 2D graphene bilayer which demonstrates a record steep subthreshold slope enabled by van Hove singularities in the density of states near the edges of conduction and valence bands. Our simulations show the accessibility of 3.5 × 104 ON/OFF current ratio with 150 mV gate voltage swing, and a maximum subthreshold slope of (20 μV/dec)‑1 just above the threshold. The high ON-state current of 0.8 mA/μm is enabled by a narrow (~0.3 eV) extrinsic band gap, while the smallness of the leakage current is due to an all-electrical doping of the source and drain contacts which suppresses the band tailing and trap-assisted tunneling.

  10. Abrupt current switching in graphene bilayer tunnel transistors enabled by van Hove singularities.

    PubMed

    Alymov, Georgy; Vyurkov, Vladimir; Ryzhii, Victor; Svintsov, Dmitry

    2016-01-01

    In a continuous search for the energy-efficient electronic switches, a great attention is focused on tunnel field-effect transistors (TFETs) demonstrating an abrupt dependence of the source-drain current on the gate voltage. Among all TFETs, those based on one-dimensional (1D) semiconductors exhibit the steepest current switching due to the singular density of states near the band edges, though the current in 1D structures is pretty low. In this paper, we propose a TFET based on 2D graphene bilayer which demonstrates a record steep subthreshold slope enabled by van Hove singularities in the density of states near the edges of conduction and valence bands. Our simulations show the accessibility of 3.5 × 10(4) ON/OFF current ratio with 150 mV gate voltage swing, and a maximum subthreshold slope of (20 μV/dec)(-1) just above the threshold. The high ON-state current of 0.8 mA/μm is enabled by a narrow (~0.3 eV) extrinsic band gap, while the smallness of the leakage current is due to an all-electrical doping of the source and drain contacts which suppresses the band tailing and trap-assisted tunneling. PMID:27098051

  11. Abrupt change in the dip of the subducting plate beneath north Chile

    NASA Astrophysics Data System (ADS)

    Contreras-Reyes, E.; Jara, J.; Grevemeyer, I.; Ruiz, S.; Carrizo, D.

    2012-05-01

    No large tsunamigenic earthquake has occurred in north Chile since 1877 and the region has been largely recognized as a mature seismic gap. At the southern end of the seismic gap, the 2007 Mw7.7 Tocopilla earthquake ruptured the deeper seismogenic interface, whereas the coupled upper interface remained unbroken. Seismological studies onshore show a gently varying dip of 20° to 30° of the downgoing Nazca plate, which extends from the trench down to depths of 40-50km. Here, we study the lithospheric structure of the subduction zone of north Chile at about 22°S, using wide-angle seismic refraction and reflection data from land and sea, complemented by hypocentre data recorded during the 2007 Tocopilla aftershocks. Our data document an abrupt increase in the dip of the subducting plate, from less than 10° to about 22°, at a depth of approximately 20km. The distribution of the 2007 aftershocks indicates that the change in dip acted as a barrier for the propagation of the 2007 earthquake towards the trench, which, in turn, indicates that the subduction megathrust is not only segmented along the trench, but also in the direction of the dip. We propose that large-magnitude tsunamigenic earthquakes must cross the barrier and rupture the entire seismogenic zone.

  12. An abrupt climate event in a coupled ocean-atmosphere simulation without external forcing.

    PubMed

    Hall, A; Stouffer, R J

    2001-01-11

    Temperature reconstructions from the North Atlantic region indicate frequent abrupt and severe climate fluctuations during the last glacial and Holocene periods. The driving forces for these events are unclear and coupled atmosphere-ocean models of global circulation have only simulated such events by inserting large amounts of fresh water into the northern North Atlantic Ocean. Here we report a drastic cooling event in a 15,000-yr simulation of global circulation with present-day climate conditions without the use of such external forcing. In our simulation, the annual average surface temperature near southern Greenland spontaneously fell 6-10 standard deviations below its mean value for a period of 30-40 yr. The event was triggered by a persistent northwesterly wind that transported large amounts of buoyant cold and fresh water into the northern North Atlantic Ocean. Oceanic convection shut down in response to this flow, concentrating the entire cooling of the northern North Atlantic by the colder atmosphere in the uppermost ocean layer. Given the similarity between our simulation and observed records of rapid cooling events, our results indicate that internal atmospheric variability alone could have generated the extreme climate disruptions in this region. PMID:11196636

  13. Theoretical basis for predicting climate-induced abrupt shifts in the oceans

    PubMed Central

    Beaugrand, Gregory

    2015-01-01

    Among the responses of marine species and their ecosystems to climate change, abrupt community shifts (ACSs), also called regime shifts, have often been observed. However, despite their effects for ecosystem functioning and both provisioning and regulating services, our understanding of the underlying mechanisms involved remains elusive. This paper proposes a theory showing that some ACSs originate from the interaction between climate-induced environmental changes and the species ecological niche. The theory predicts that a substantial stepwise shift in the thermal regime of a marine ecosystem leads indubitably to an ACS and explains why some species do not change during the phenomenon. It also explicates why the timing of ACSs may differ or why some studies may detect or not detect a shift in the same ecosystem, independently of the statistical method of detection and simply because they focus on different species or taxonomic groups. The present theory offers a way to predict future climate-induced community shifts and their potential associated trophic cascades and amplifications.

  14. Plasma Stress Responses in Juvenile Red-Spotted Grouper (Epinephelus akaara) exposed to Abrupt Salinity Decrease

    PubMed Central

    Lee, Jang-Won; Kim, Hyung Bae; Baek, Hea Ja

    2016-01-01

    The objective of the current study was to determine acute plasma stress responses in two size groups of juvenile Epinephelus akaara (average body weight: 8.4±2.1 and 3.3±0.6 g; 150 and 120 days after hatch, respectively) exposed to abrupt salinity drops (from 34 practical salinity unit, PSU seawater to 18, 10 PSU (experiment 1) or 26, 18, 10 PSU (experiment 2), respectively). Plasma glucose, glutamic oxalate transaminase, glutamic pyruvate transaminase, red blood cell counts, and gill histology were determined during 72 h exposure. Significantly increased plasma glucose, glutamic oxalate transaminase levels, and red blood cell counts were observed in fish exposed to 18 or 10 PSU. Histological changes, such as hyperplasia and lifting of epithelium in the gill secondary lamellae, were also observed in fish exposed to 18 or 10 PSU at 72 h post-drop. E. akaara exposed to sudden salinity drops to 18 or 10 PSU still seems to undergo the primary adjustment phase before fish reaches a new homeostasis, whereas fish exposed to 26 PSU seems to mount osmotic changes. Therefore, the no observed adverse effect levels for 72 h acute salinity challenge was 26 PSU in our study, and salinity drop to 18 PSU and below can possibly cause acute adverse effect, in which fish could be vulnerable to additional stresses such as a temperature changes or handling stress. PMID:27796000

  15. Abrupt changes in Antarctic Intermediate Water circulation over the past 25,000years

    NASA Astrophysics Data System (ADS)

    Pahnke, Katharina; Goldstein, Steven L.; Hemming, Sidney R.

    2008-12-01

    The circulation of Antarctic Intermediate Water is thought to make an important contribution to the global ocean-climate system, but the details of this interaction are not fully understood. Furthermore, the behaviour of Antarctic Intermediate Water under glacial and interglacial conditions is not well constrained. Here we present a 25,000-year-long record of neodymium isotopic variations-a tracer of water-mass mixing-from the middle depths of the tropical Atlantic Ocean. Our data reveal abruptly enhanced northward advection of Antarctic Intermediate Water during periods of reduced North Atlantic overturning circulation during the last deglaciation. These events coincide with an increase in the formation of Antarctic Intermediate Water and warming in the southwest Pacific Ocean, which suggests a tight link with Southern Hemisphere climate. In contrast, the initial incursion of southern source water into the North Atlantic ~19,000years ago coincided with weak Antarctic Intermediate Water formation in the Pacific and reduced overturning in the North Atlantic. We conclude that reduced competition at intermediate water depth at this time allowed expansion of Antarctic Intermediate Water into the North Atlantic. This early incursion of Antarctic Intermediate Water may have contributed to freshening of the North Atlantic, perhaps spurring the subsequent collapse of North Atlantic deep convection.

  16. Impact of abrupt deglacial climate change on tropical Atlantic subsurface temperatures

    PubMed Central

    Schmidt, Matthew W.; Chang, Ping; Hertzberg, Jennifer E.; Them, Theodore R.; Ji, Link; Otto-Bliesner, Bette L.

    2012-01-01

    Both instrumental data analyses and coupled ocean-atmosphere models indicate that Atlantic meridional overturning circulation (AMOC) variability is tightly linked to abrupt tropical North Atlantic (TNA) climate change through both atmospheric and oceanic processes. Although a slowdown of AMOC results in an atmospheric-induced surface cooling in the entire TNA, the subsurface experiences an even larger warming because of rapid reorganizations of ocean circulation patterns at intermediate water depths. Here, we reconstruct high-resolution temperature records using oxygen isotope values and Mg/Ca ratios in both surface- and subthermocline-dwelling planktonic foraminifera from a sediment core located in the TNA over the last 22 ky. Our results show significant changes in the vertical thermal gradient of the upper water column, with the warmest subsurface temperatures of the last deglacial transition corresponding to the onset of the Younger Dryas. Furthermore, we present new analyses of a climate model simulation forced with freshwater discharge into the North Atlantic under Last Glacial Maximum forcings and boundary conditions that reveal a maximum subsurface warming in the vicinity of the core site and a vertical thermal gradient change at the onset of AMOC weakening, consistent with the reconstructed record. Together, our proxy reconstructions and modeling results provide convincing evidence for a subsurface oceanic teleconnection linking high-latitude North Atlantic climate to the tropical Atlantic during periods of reduced AMOC across the last deglacial transition. PMID:22908256

  17. Impact of abrupt deglacial climate change on tropical Atlantic subsurface temperatures.

    PubMed

    Schmidt, Matthew W; Chang, Ping; Hertzberg, Jennifer E; Them, Theodore R; Ji, Link; J, Link; Otto-Bliesner, Bette L

    2012-09-01

    Both instrumental data analyses and coupled ocean-atmosphere models indicate that Atlantic meridional overturning circulation (AMOC) variability is tightly linked to abrupt tropical North Atlantic (TNA) climate change through both atmospheric and oceanic processes. Although a slowdown of AMOC results in an atmospheric-induced surface cooling in the entire TNA, the subsurface experiences an even larger warming because of rapid reorganizations of ocean circulation patterns at intermediate water depths. Here, we reconstruct high-resolution temperature records using oxygen isotope values and Mg/Ca ratios in both surface- and subthermocline-dwelling planktonic foraminifera from a sediment core located in the TNA over the last 22 ky. Our results show significant changes in the vertical thermal gradient of the upper water column, with the warmest subsurface temperatures of the last deglacial transition corresponding to the onset of the Younger Dryas. Furthermore, we present new analyses of a climate model simulation forced with freshwater discharge into the North Atlantic under Last Glacial Maximum forcings and boundary conditions that reveal a maximum subsurface warming in the vicinity of the core site and a vertical thermal gradient change at the onset of AMOC weakening, consistent with the reconstructed record. Together, our proxy reconstructions and modeling results provide convincing evidence for a subsurface oceanic teleconnection linking high-latitude North Atlantic climate to the tropical Atlantic during periods of reduced AMOC across the last deglacial transition.

  18. Stalagmite-inferred abrupt hydroclimate changes in the central Mediterranean over the past 6500 years

    NASA Astrophysics Data System (ADS)

    Hu, H. M.; Shen, C. C.; Jiang, X.; Wang, Y.; Mii, H. S.

    2015-12-01

    Mediterranean, as one of the global climate change "hot spots", was faced with severe drought over the recent decades. Investigation of regional paleo-hydroclimate evolution helps improve climate projection and adaption strategy. Here, we present a new decadal-resolved record documenting hydroclimate in the central Mediterranean from an Italian stalagmite since 6500 years ago. Eighty high-precision absolute U-Th dates with 2-sigma uncertainty better than ±20 years and 560 oxygen isotopic ratio data show several abrupt drying events with an average of 600 mm precipitation decrease in less than 80 years since the mid-Holocene. North Atlantic Oscillation (NAO) could dominantly govern the centennial-scale hydroclimate variability, especially for a period of 4500 to 2000 years ago. Total solar irradiance (TSI) also partially affected this regional precipitation. The obscure relationship between stalagmite and global/local mean surface temperature sequences, in contradict to previous studies, implies complex internal feedback of global warming and atmospheric circulation in the Mediterranean. Our result suggests that the twenty-first century Mediterranean drying trend is significant but not unprecedented in the past six thousand years.

  19. Free-To-Roll Analysis of Abrupt Wing Stall on Military Aircraft at Transonic Speeds

    NASA Technical Reports Server (NTRS)

    Owens, D. Bruce; Capone, Francis J.; Brandon, Jay M.; Cunningham, Kevin; Chambers, Joseph R.

    2003-01-01

    Transonic free-to-roll and static wind tunnel tests for four military aircraft - the AV-8B, the F/A-18C, the preproduction F/A-18E, and the F-16C - have been analyzed. These tests were conducted in the NASA Langley 16-Foot Transonic Tunnel as a part of the NASA/Navy/Air Force Abrupt Wing Stall Program. The objectives were to evaluate the utility of the free-to-roll test technique as a tool for predicting areas of significant uncommanded lateral motions and for gaining insight into the wing-drop and wing-rock behavior of military aircraft at transonic conditions. The analysis indicated that the free-to-roll results had good agreement with flight data on all four models. A wide range of motions - limit cycle wing rock, occasional and frequent damped wing drop/rock and wing rock divergence - were observed. The analysis shows the effects that the static and dynamic lateral stability can have on the wing drop/rock behavior. In addition, a free-to-roll figure of merit was developed to assist in the interpretation of results and assessment of the severity of the motions.

  20. Gain control through divisive inhibition prevents abrupt transition to chaos in a neural mass model

    NASA Astrophysics Data System (ADS)

    Papasavvas, Christoforos A.; Wang, Yujiang; Trevelyan, Andrew J.; Kaiser, Marcus

    2015-09-01

    Experimental results suggest that there are two distinct mechanisms of inhibition in cortical neuronal networks: subtractive and divisive inhibition. They modulate the input-output function of their target neurons either by increasing the input that is needed to reach maximum output or by reducing the gain and the value of maximum output itself, respectively. However, the role of these mechanisms on the dynamics of the network is poorly understood. We introduce a novel population model and numerically investigate the influence of divisive inhibition on network dynamics. Specifically, we focus on the transitions from a state of regular oscillations to a state of chaotic dynamics via period-doubling bifurcations. The model with divisive inhibition exhibits a universal transition rate to chaos (Feigenbaum behavior). In contrast, in an equivalent model without divisive inhibition, transition rates to chaos are not bounded by the universal constant (non-Feigenbaum behavior). This non-Feigenbaum behavior, when only subtractive inhibition is present, is linked to the interaction of bifurcation curves in the parameter space. Indeed, searching the parameter space showed that such interactions are impossible when divisive inhibition is included. Therefore, divisive inhibition prevents non-Feigenbaum behavior and, consequently, any abrupt transition to chaos. The results suggest that the divisive inhibition in neuronal networks could play a crucial role in keeping the states of order and chaos well separated and in preventing the onset of pathological neural dynamics.

  1. Direct observation of an abrupt insulator-to-metal transition in dense liquid deuterium

    NASA Astrophysics Data System (ADS)

    Knudson, Marcus; Desjarlais, Michael; Becker, Andeas; Lemke, Raymond; Cochrane, Kyle; Savage, Mark; Bliss, David; Mattsson, Thomas; Redmer, Ronald

    2015-06-01

    Recently a so-called shock-ramp platform has been developed on the Sandia Z Accelerator to access off-Hugoniot states in liquids. The accelerator delivers a two-step current pulse; the first accelerates the electrode to a reasonably constant velocity, which upon impact with the sample cell creates a well-defined shock, the subsequent current rise produces ramp compression from the initially shocked state. This technique generates relatively cool (~1-2 kK), high pressure (>300 GPa), high compression (~10-15 fold compression) states, allowing experimental access to the region of phase space where hydrogen is predicted to undergo a first-order phase transition from an insulating molecular-like liquid to a conducting atomic-like liquid. In this talk we will discuss the experimental platform, survey the various theoretical predictions for the liquid-liquid, insulator-to-metal transition in hydrogen, and present the results of experiments that clearly show an abrupt transition to a metallic state. Sandia National Laboratories is a multi-program laboratory managed and operated by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin Corporation, for the U.S. Department of Energy's National Nuclear Security Administration under contract DE-AC04-94AL85000.

  2. 5 CFR 300.604 - Restrictions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS EMPLOYMENT (GENERAL) Time-In-Grade Restrictions § 300.604 Restrictions. The following time-in-grade restrictions must be met unless... may be advanced without time restriction to positions up to GS-5 if the position to be filled is...

  3. 5 CFR 300.604 - Restrictions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS EMPLOYMENT (GENERAL) Time-In-Grade Restrictions § 300.604 Restrictions. The following time-in-grade restrictions must be met unless... may be advanced without time restriction to positions up to GS-5 if the position to be filled is...

  4. 5 CFR 300.604 - Restrictions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS EMPLOYMENT (GENERAL) Time-In-Grade Restrictions § 300.604 Restrictions. The following time-in-grade restrictions must be met unless... may be advanced without time restriction to positions up to GS-5 if the position to be filled is...

  5. 5 CFR 300.604 - Restrictions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS EMPLOYMENT (GENERAL) Time-In-Grade Restrictions § 300.604 Restrictions. The following time-in-grade restrictions must be met unless... may be advanced without time restriction to positions up to GS-5 if the position to be filled is...

  6. 5 CFR 300.604 - Restrictions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS EMPLOYMENT (GENERAL) Time-In-Grade Restrictions § 300.604 Restrictions. The following time-in-grade restrictions must be met unless... may be advanced without time restriction to positions up to GS-5 if the position to be filled is...

  7. 49 CFR 215.203 - Restricted cars.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 4 2012-10-01 2012-10-01 false Restricted cars. 215.203 Section 215.203..., DEPARTMENT OF TRANSPORTATION RAILROAD FREIGHT CAR SAFETY STANDARDS Restricted Equipment § 215.203 Restricted cars. (a) This section restricts the operation of any railroad freight car that is— (1) More than...

  8. 49 CFR 215.203 - Restricted cars.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 4 2014-10-01 2014-10-01 false Restricted cars. 215.203 Section 215.203..., DEPARTMENT OF TRANSPORTATION RAILROAD FREIGHT CAR SAFETY STANDARDS Restricted Equipment § 215.203 Restricted cars. (a) This section restricts the operation of any railroad freight car that is— (1) More than...

  9. 49 CFR 215.203 - Restricted cars.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 4 2013-10-01 2013-10-01 false Restricted cars. 215.203 Section 215.203..., DEPARTMENT OF TRANSPORTATION RAILROAD FREIGHT CAR SAFETY STANDARDS Restricted Equipment § 215.203 Restricted cars. (a) This section restricts the operation of any railroad freight car that is— (1) More than...

  10. 49 CFR 215.203 - Restricted cars.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Restricted cars. 215.203 Section 215.203..., DEPARTMENT OF TRANSPORTATION RAILROAD FREIGHT CAR SAFETY STANDARDS Restricted Equipment § 215.203 Restricted cars. (a) This section restricts the operation of any railroad freight car that is— (1) More than...

  11. 49 CFR 215.203 - Restricted cars.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 4 2011-10-01 2011-10-01 false Restricted cars. 215.203 Section 215.203..., DEPARTMENT OF TRANSPORTATION RAILROAD FREIGHT CAR SAFETY STANDARDS Restricted Equipment § 215.203 Restricted cars. (a) This section restricts the operation of any railroad freight car that is— (1) More than...

  12. Overcoming Communication Restrictions in Collectives

    NASA Technical Reports Server (NTRS)

    Tumer, Kagan; Agogino, Adrian K.

    2004-01-01

    Many large distributed system are characterized by having a large number of components (eg., agents, neurons) whose actions and interactions determine a %orld utility which rates the performance of the overall system. Such collectives are often subject to communication restrictions, making it difficult for components which try to optimize their own private utilities, to take actions that also help optimize the world utility. In this article we address that coordination problem and derive four utility functions which present different compromises between how aligned a component s private utility is with the world utility and how readily that component can determine the actions that optimize its utility. The results show that the utility functions specifically derived to operate under communication restrictions outperform both traditional methods and previous collective-based methods by up to 75%.

  13. Temperature based Restricted Boltzmann Machines.

    PubMed

    Li, Guoqi; Deng, Lei; Xu, Yi; Wen, Changyun; Wang, Wei; Pei, Jing; Shi, Luping

    2016-01-13

    Restricted Boltzmann machines (RBMs), which apply graphical models to learning probability distribution over a set of inputs, have attracted much attention recently since being proposed as building blocks of multi-layer learning systems called deep belief networks (DBNs). Note that temperature is a key factor of the Boltzmann distribution that RBMs originate from. However, none of existing schemes have considered the impact of temperature in the graphical model of DBNs. In this work, we propose temperature based restricted Boltzmann machines (TRBMs) which reveals that temperature is an essential parameter controlling the selectivity of the firing neurons in the hidden layers. We theoretically prove that the effect of temperature can be adjusted by setting the parameter of the sharpness of the logistic function in the proposed TRBMs. The performance of RBMs can be improved by adjusting the temperature parameter of TRBMs. This work provides a comprehensive insights into the deep belief networks and deep learning architectures from a physical point of view.

  14. Temperature based Restricted Boltzmann Machines

    NASA Astrophysics Data System (ADS)

    Li, Guoqi; Deng, Lei; Xu, Yi; Wen, Changyun; Wang, Wei; Pei, Jing; Shi, Luping

    2016-01-01

    Restricted Boltzmann machines (RBMs), which apply graphical models to learning probability distribution over a set of inputs, have attracted much attention recently since being proposed as building blocks of multi-layer learning systems called deep belief networks (DBNs). Note that temperature is a key factor of the Boltzmann distribution that RBMs originate from. However, none of existing schemes have considered the impact of temperature in the graphical model of DBNs. In this work, we propose temperature based restricted Boltzmann machines (TRBMs) which reveals that temperature is an essential parameter controlling the selectivity of the firing neurons in the hidden layers. We theoretically prove that the effect of temperature can be adjusted by setting the parameter of the sharpness of the logistic function in the proposed TRBMs. The performance of RBMs can be improved by adjusting the temperature parameter of TRBMs. This work provides a comprehensive insights into the deep belief networks and deep learning architectures from a physical point of view.

  15. An abrupt weakening of the subpolar gyre as trigger of Little Ice Age-type episodes

    NASA Astrophysics Data System (ADS)

    Moreno-Chamarro, Eduardo; Zanchettin, Davide; Lohmann, Katja; Jungclaus, Johann H.

    2016-04-01

    We investigate the mechanism of a decadal-scale weakening shift in the strength of the subpolar gyre (SPG) that is found in one among three last millennium simulations with a state-of-the-art Earth system model. The SPG shift triggers multicentennial anomalies in the North Atlantic climate driven by long-lasting internal feedbacks relating anomalous oceanic and atmospheric circulation, sea ice extent, and upper-ocean salinity in the Labrador Sea. Yet changes throughout or after the shift are not associated with a persistent weakening of the Atlantic Meridional Overturning Circulation or shifts in the North Atlantic Oscillation. The anomalous climate state of the North Atlantic simulated after the shift agrees well with climate reconstructions from within the area, which describe a transition between a stronger and weaker SPG during the relatively warm medieval climate and the cold Little Ice Age respectively. However, model and data differ in the timing of the onset. The simulated SPG shift is caused by a rapid increase in the freshwater export from the Arctic and associated freshening in the upper Labrador Sea. Such freshwater anomaly relates to prominent thickening of the Arctic sea ice, following the cluster of relatively small-magnitude volcanic eruptions by 1600 CE. Sensitivity experiments without volcanic forcing can nonetheless produce similar abrupt events; a necessary causal link between the volcanic cluster and the SPG shift can therefore be excluded. Instead, preconditioning by internal variability explains discrepancies in the timing between the simulated SPG shift and the reconstructed estimates for the Little Ice Age onset.

  16. Response of atmospheric CO2 to the abrupt cooling event 8200 years ago

    NASA Astrophysics Data System (ADS)

    Ahn, J.; Brook, E.; Buizert, C.

    2013-12-01

    The abrupt cooling event 8200 years ago (8.2 ka event) is the most prominent centennial scale climate event during the Holocene and was likely caused by a reduction in the Atlantic meridional overturning circulation (AMOC). Atmospheric CO2 records for this event may help us understand climate-carbon cycle feedbacks under interglacial conditions, which are important for understanding future climate, but existing ice core records do not provide enough detail and natural smoothing of the CO2 time series by diffusion and gradual bubble close-off in the firn layer (unconsolidated snow layer in the top of ice sheets) limits their resolution. Studies of leaf stomata records suggest a CO2 decrease of up to ~25 ppm during the 8.2 ka event, but relatively large uncertainties in reconstructed CO2 levels from leaves and dating make firm conclusions difficult. Here we present a new CO2 record from the Siple Dome ice core, Antarctica, that covers 7.4-9.0 ka with 8- to 16-year resolution. The relatively high snow accumulation rate at Siple Dome results minimizes smoothing relative to other records and the timing of the 8.2 ka event is precisely constrained by a CH4 record from the same core. We observe a small, ~2 ppm, increase of atmospheric CO2 during the 8.2 ka event. The increase is not remarkable when compared to other centennial variations in the Holocene that are not linked to large temperature changes. Our results imply that the sensitivity of atmospheric CO2 to the primarily northern hemisphere cooling of the 8.2 ka event was limited.

  17. Abrupt acceleration of a 'cold' ultrarelativistic wind from the Crab pulsar.

    PubMed

    Aharonian, F A; Bogovalov, S V; Khangulyan, D

    2012-02-23

    Pulsars are thought to eject electron-positron winds that energize the surrounding environment, with the formation of a pulsar wind nebula. The pulsar wind originates close to the light cylinder, the surface at which the pulsar co-rotation velocity equals the speed of light, and carries away much of the rotational energy lost by the pulsar. Initially the wind is dominated by electromagnetic energy (Poynting flux) but later this is converted to the kinetic energy of bulk motion. It is unclear exactly where this takes place and to what speed the wind is accelerated. Although some preferred models imply a gradual acceleration over the entire distance from the magnetosphere to the point at which the wind terminates, a rapid acceleration close to the light cylinder cannot be excluded. Here we report that the recent observations of pulsed, very high-energy γ-ray emission from the Crab pulsar are explained by the presence of a cold (in the sense of the low energy of the electrons in the frame of the moving plasma) ultrarelativistic wind dominated by kinetic energy. The conversion of the Poynting flux to kinetic energy should take place abruptly in the narrow cylindrical zone of radius between 20 and 50 light-cylinder radii centred on the axis of rotation of the pulsar, and should accelerate the wind to a Lorentz factor of (0.5-1.0) × 10(6). Although the ultrarelativistic nature of the wind does support the general model of pulsars, the requirement of the very high acceleration of the wind in a narrow zone not far from the light cylinder challenges current models. PMID:22343893

  18. Progressive increase in mtDNA 3243A>G heteroplasmy causes abrupt transcriptional reprogramming.

    PubMed

    Picard, Martin; Zhang, Jiangwen; Hancock, Saege; Derbeneva, Olga; Golhar, Ryan; Golik, Pawel; O'Hearn, Sean; Levy, Shawn; Potluri, Prasanth; Lvova, Maria; Davila, Antonio; Lin, Chun Shi; Perin, Juan Carlos; Rappaport, Eric F; Hakonarson, Hakon; Trounce, Ian A; Procaccio, Vincent; Wallace, Douglas C

    2014-09-23

    Variation in the intracellular percentage of normal and mutant mitochondrial DNAs (mtDNA) (heteroplasmy) can be associated with phenotypic heterogeneity in mtDNA diseases. Individuals that inherit the common disease-causing mtDNA tRNA(Leu(UUR)) 3243A>G mutation and harbor ∼10-30% 3243G mutant mtDNAs manifest diabetes and occasionally autism; individuals with ∼50-90% mutant mtDNAs manifest encephalomyopathies; and individuals with ∼90-100% mutant mtDNAs face perinatal lethality. To determine the basis of these abrupt phenotypic changes, we generated somatic cell cybrids harboring increasing levels of the 3243G mutant and analyzed the associated cellular phenotypes and nuclear DNA (nDNA) and mtDNA transcriptional profiles by RNA sequencing. Small increases in mutant mtDNAs caused relatively modest defects in oxidative capacity but resulted in sharp transitions in cellular phenotype and gene expression. Cybrids harboring 20-30% 3243G mtDNAs had reduced mtDNA mRNA levels, rounded mitochondria, and small cell size. Cybrids with 50-90% 3243G mtDNAs manifest induction of glycolytic genes, mitochondrial elongation, increased mtDNA mRNA levels, and alterations in expression of signal transduction, epigenomic regulatory, and neurodegenerative disease-associated genes. Finally, cybrids with 100% 3243G experienced reduced mtDNA transcripts, rounded mitochondria, and concomitant changes in nuclear gene expression. Thus, striking phase changes occurred in nDNA and mtDNA gene expression in response to the modest changes of the mtDNA 3243G mutant levels. Hence, a major factor in the phenotypic variation in heteroplasmic mtDNA mutations is the limited number of states that the nucleus can acquire in response to progressive changes in mitochondrial retrograde signaling. PMID:25192935

  19. Fluvial response to abrupt global warming at the Palaeocene/Eocene boundary.

    PubMed

    Foreman, Brady Z; Heller, Paul L; Clementz, Mark T

    2012-11-01

    Climate strongly affects the production of sediment from mountain catchments as well as its transport and deposition within adjacent sedimentary basins. However, identifying climatic influences on basin stratigraphy is complicated by nonlinearities, feedback loops, lag times, buffering and convergence among processes within the sediment routeing system. The Palaeocene/Eocene thermal maximum (PETM) arguably represents the most abrupt and dramatic instance of global warming in the Cenozoic era and has been proposed to be a geologic analogue for anthropogenic climate change. Here we evaluate the fluvial response in western Colorado to the PETM. Concomitant with the carbon isotope excursion marking the PETM we document a basin-wide shift to thick, multistoried, sheets of sandstone characterized by variable channel dimensions, dominance of upper flow regime sedimentary structures, and prevalent crevasse splay deposits. This progradation of coarse-grained lithofacies matches model predictions for rapid increases in sediment flux and discharge, instigated by regional vegetation overturn and enhanced monsoon precipitation. Yet the change in fluvial deposition persisted long after the approximately 200,000-year-long PETM with its increased carbon dioxide levels in the atmosphere, emphasizing the strong role the protracted transmission of catchment responses to distant depositional systems has in constructing large-scale basin stratigraphy. Our results, combined with evidence for increased dissolved loads and terrestrial clay export to world oceans, indicate that the transient hyper-greenhouse climate of the PETM may represent a major geomorphic 'system-clearing event', involving a global mobilization of dissolved and solid sediment loads on Earth's surface.

  20. Abrupt Climate Events Recorded in Chinese and Central Asian Loess Sequences

    NASA Astrophysics Data System (ADS)

    Machalett, B.; Oches, E. A.; Haam, E. K.; Lai, Z.; Endlicher, W.

    2013-12-01

    of suborbital global climate changes and an initiator of abrupt climate oscillations in the Northern Hemisphere.

  1. Abrupt Climate Events Recorded in Chinese and Central Asian Loess Sequences

    NASA Astrophysics Data System (ADS)

    Machalett, Bjoern; Oches, Eric A.; Haam, Eddie; Lai, Zhongping; Endlicher, Wilfried

    2013-04-01

    of suborbital global climate changes and an initiator of abrupt climate oscillations in the Northern Hemisphere.

  2. Transonic Unsteady Aerodynamics of the F/A-18E at Conditions Promoting Abrupt Wing Stall

    NASA Technical Reports Server (NTRS)

    Schuster, David M.; Byrd, James E.

    2003-01-01

    A transonic wind tunnel test of an 8% F/A-18E model was conducted in the NASA Langley Research Center (LaRC) 16-Foot Transonic Tunnel (16-Ft TT) to investigate the Abrupt Wing Stall (AWS) characteristics of this aircraft. During this test, both steady and unsteady measurements of balance loads, wing surface pressures, wing root bending moments, and outer wing accelerations were performed. The test was conducted with a wide range of model configurations and test conditions in an attempt to reproduce behavior indicative of the AWS phenomenon experienced on full-scale aircraft during flight tests. This paper focuses on the analysis of the unsteady data acquired during this test. Though the test apparatus was designed to be effectively rigid. model motions due to sting and balance flexibility were observed during the testing, particularly when the model was operating in the AWS flight regime. Correlation between observed aerodynamic frequencies and model structural frequencies are analyzed and presented. Significant shock motion and separated flow is observed as the aircraft pitches through the AWS region. A shock tracking strategy has been formulated to observe this phenomenon. Using this technique, the range of shock motion is readily determined as the aircraft encounters AWS conditions. Spectral analysis of the shock motion shows the frequencies at which the shock oscillates in the AWS region, and probability density function analysis of the shock location shows the propensity of the shock to take on a bi-stable and even tri-stable character in the AWS flight regime.

  3. Abrupt acceleration of a 'cold' ultrarelativistic wind from the Crab pulsar.

    PubMed

    Aharonian, F A; Bogovalov, S V; Khangulyan, D

    2012-02-15

    Pulsars are thought to eject electron-positron winds that energize the surrounding environment, with the formation of a pulsar wind nebula. The pulsar wind originates close to the light cylinder, the surface at which the pulsar co-rotation velocity equals the speed of light, and carries away much of the rotational energy lost by the pulsar. Initially the wind is dominated by electromagnetic energy (Poynting flux) but later this is converted to the kinetic energy of bulk motion. It is unclear exactly where this takes place and to what speed the wind is accelerated. Although some preferred models imply a gradual acceleration over the entire distance from the magnetosphere to the point at which the wind terminates, a rapid acceleration close to the light cylinder cannot be excluded. Here we report that the recent observations of pulsed, very high-energy γ-ray emission from the Crab pulsar are explained by the presence of a cold (in the sense of the low energy of the electrons in the frame of the moving plasma) ultrarelativistic wind dominated by kinetic energy. The conversion of the Poynting flux to kinetic energy should take place abruptly in the narrow cylindrical zone of radius between 20 and 50 light-cylinder radii centred on the axis of rotation of the pulsar, and should accelerate the wind to a Lorentz factor of (0.5-1.0) × 10(6). Although the ultrarelativistic nature of the wind does support the general model of pulsars, the requirement of the very high acceleration of the wind in a narrow zone not far from the light cylinder challenges current models.

  4. Iceberg discharges and oceanic circulation changes during glacial abrupt climate changes

    NASA Astrophysics Data System (ADS)

    Alvarez-Solas, Jorge; Robinson, Alexander; Banderas, Rubén; Montoya, Marisa

    2015-04-01

    Proxy data reveal the existence of episodes of increased deposition of ice-rafted debris in the North Atlantic Ocean during the last glacial period. These are interpreted as massive iceberg discharges mainly from the Laurentide Ice Sheet. Although these have long been attributed to self-sustained ice sheet oscillations, growing evidence points to an active role of the oceanic circulation. Here we will present simulations of the last glacial period carried out with a hybrid ice sheet-ice shelf model. Two mechanisms producing iceberg discharges are compared. First, we reproduce the classic binge-purge by which the iceberg surges are produced thanks to the existence of an internal thermo-mechanical feedback that allows the ice sheet to behave under an oscillatory regime. Second, our ice-sheet model is forced by an oceanic warming index derived from proxy data that accounts for the impact of past ocean circulation changes on ocean temperatures. In this case, the model generates a time series of iceberg calving that agrees with ice-rafted debris records over the past 80 ka. We compare the two theories and discuss their advantages and weaknesses in terms of both the robustness of the physics on which they are based and their comparison with proxies. This comparison highlights the importance of considering past oceanic circulation changes in order to understand the ice-sheet dynamics. However, the ultimate processes determining abrupt changes in the Atlantic Meridional Overturning Circulation (AMOC) remain elusive. Therefore we will also analyze several proposed mechanisms that aims to explain such AMOC reorganizations, focusing on those that do not require freshwater flux forcing.

  5. Abrupt climate changes in northwestern Colombia during the Lateglacial and Holocene transition

    NASA Astrophysics Data System (ADS)

    Velasquez Ruiz, C.

    2013-05-01

    High resolution pollen/spores records from Paramo de Frontino (6, 29N, 76, 6W) and Paramo de Belmira (6,42'N, 75,40'W) in Colombia (Velásquez C. and H. Hooghiemstra, Paleobotany, 2012 in press; Velásquez C., et al., in preparation) spanning 17300 and 34000 cal yr BP; are studied for abrupt climatic change and compared with a La Cocha diatom record (Gonzalez, Z, et al., 2012), Frontino and Cariaco Basin (offshore Venezuela) titanium records and a Cariaco sea surface temperatures record (Gorin, G., et al, in preparation; Haug, et al., 2001; Lea D., et al., 2003; respectively); in reference to detected vegetation and climate variations. The most remarkable events occurred at 8200, 9300, 10400, 12000, 13500, 14.5-14.7, 16.2 and 21.4 cal yr BP. Low frequency cycles of 1500-2500 yr are present along the records suggesting that the North Atlantic Bond Cycles are also registered in northwestern South American terrestrial records. Some of these changes were dry while others wet, showing that both patterns "Cold poles, dry tropics" and "Cold poles, wet tropics" can be expressed. It was also found that the estimated temperatures from Paramo de Frontino (pollen based) and sea surface temperatures in Cariaco followed a similar trend during the the Late Glacial and Early Holocene. However, in the case of moisture, the Titanium record (indicative of rainfall) from the Cariaco Basin, the aquatic vegetation pollen and titanium records from Paramo de Frontino and diatoms record from La Cocha lake, showed a clear antiphase behavior during the same periods. Position and shape of Intertropical Convergence Zone are postulated as responsible for this variation. Keywords: palinology, Intertropical Convergence Zone, titanium, Colombia, climatic and vegetation changes.

  6. Reducing The Risk Of Abrupt Climate Change: Emission Corridors Preserving The Thermohaline Circulation

    NASA Astrophysics Data System (ADS)

    Zickfeld, K.

    Paleo-reconstructions have shown that large and abrupt climate changes have occurred throughout the last ice-age cycles. This evidence, supplemented by insights into the complex and nonlinear nature of the climate system, gives raise to the concern that anthropogenic forcing may trigger such events in the future. A prominent example for such a potential climatic shift is the collapse of the North Atlantic thermohaline circu- lation (THC), which would cause a major cooling of the northern North Atlantic and north-western Europe and considerable regional sea level rise, with possibly severe consequences on, e.g., fisheries, agriculture and ecosystems. In this paper we present emission corridors for the 21st century preserving the THC. Emission corridors embrace the range of future emissions beyond which either the THC collapses or the mitigation burden becomes intolerable. They are calculated along the conceptual and methodological lines of the tolerable windows approach. We investigate the sensitivity of the emission corridors to the main uncertain parame- ters (climate and North Atlantic hydrological sensitivities as well as emissions of non CO_2 greenhouse gases). Results show a high dependence of the size of the emis- sion corridors on hydrological and climate sensitivities. For the best-guess values of both parameters we find that the emission corridors are wider than the range spanned by the SRES emissions scenarios. Thus, no immediate mitigation seems necessary in order to preserve the THC. For high but still realistic values of the sensitivities, however, even the low SRES emissions scenarios transgress the corridor boundaries. These findings imply that under 'business as usual' a non-negligible risk of either a THC collapse or an intolerable mitigation burden exists.

  7. Controlled comparison of the effects and abrupt discontinuation of buspirone and lorazepam.

    PubMed

    Bourin, M; Malinge, M

    1995-07-01

    1. The purpose of this study was to compare the effects and abrupt discontinuation of buspirone 15 or 20 mg tid and lorazepam 3 or 4 mg tid following 8 weeks of treatment. A total of 43 outpatients with generalized anxiety disorder were included in the study and 39 entered the withdrawal phase. 2. Clinical assessments were performed at baseline, 2, 4, 6 and 8 weeks (active phase) and after 9 and 10 weeks (withdrawal phase). These included the Hamilton anxiety scale, the visual analogue scale, the CHESS 84 (a check list for the evaluation of somatic symptoms) and the Lader tranquilizer withdrawal scale (translated in french). 3. Results show similar efficacy for lorazepam and buspirone during the active phase with a higher significant difference for buspirone on the CHESS 84 in relation with neurovegetatives symptoms: lorazepam D0 :16.30 +/- 3.14 D56: 5.10 +/- 0.93 (p < or = 0.01) buspirone D0 :18.82 +/- 3.4 D56: 4.73 +/- 1.18 (p < or = 0.001) No withdrawal phenomena was observed for both drugs using HAM-A lorazepam D63 :12.59 +/- 2.26 D70: 12.0 +/- 1.75 (p = ns) buspirone D63 :10.05 +/- 1.28 D70: 10.32 +/- 1.82 (p = ns) and the same significant difference using Lader scale: lorazepam D63 :4.44 +/- 0.89 D70: 6.96 +/- 1.28 (p < or = 0.05) buspirone D63 :2.95 +/- 0.66 D70: 4.15 +/- 0.92 (p < or = 0.05). 4. This study confirmed that buspirone was as effective as lorazepam at D56 in monitored outpatients with generalized anxiety disorder.(ABSTRACT TRUNCATED AT 250 WORDS)

  8. Abrupt cooling associated with the oceanic Rossby wave and lateral advection during CINDY2011

    NASA Astrophysics Data System (ADS)

    Seiki, Ayako; Katsumata, Masaki; Horii, Takanori; Hasegawa, Takuya; Richards, Kelvin J.; Yoneyama, Kunio; Shirooka, Ryuichi

    2013-10-01

    The cooperative Indian Ocean experiment on intraseasonal variability in the Year 2011 (CINDY2011) was conducted to capture atmospheric and oceanic characteristics of the Madden-Julian Oscillation (MJO) in the central Indian Ocean from late 2011 to early 2012. During CINDY2011, the research vessel (R/V) MIRAI stayed at 8°S, 80.5°E for two months during the special observing period (SOP). Intraseasonal convection associated with the MJO was organized in the central Indian Ocean in late October and late November during the SOP. In the middle of November, both sea surface temperature (SST) and mixed layer temperature decreased suddenly when cold low salinity water intruded into the upper layer around the R/V MIRAI. This intrusion was accompanied by a surface current change from southwestward to westward/west-northwestward associated with the passage of the annual oceanic downwelling Rossby wave. The mixed layer heat budget analysis shows that horizontal advection plays an important role in the abrupt cooling whereas the net surface heat flux cannot account for the cooling. This is an interesting result because the associated downwelling Rossby wave is usually considered to increase SST through a reduction of entrainment cooling. In addition, for the second MJO event convection was activated around 20 November over the central north and equatorial Indian Ocean but not in the south. It is suggested that the cooler surface waters (as seen at the location of the R/V MIRAI) tended to suppress the initial atmospheric convection, resulting in the lagged convective onset in the end of November over the central south Indian Ocean.

  9. Sea-level response to abrupt ocean warming of Antarctic ice shelves

    NASA Astrophysics Data System (ADS)

    Pattyn, Frank

    2016-04-01

    Antarctica's contribution to global sea-level rise increases steadily. A fundamental question remains whether the ice discharge will lead to marine ice sheet instability (MISI) and collapse of certain sectors of the ice sheet or whether ice loss will increase linearly with the warming trends. Therefore, we employ a newly developed ice sheet model of the Antarctic ice sheet, called f.ETISh (fast Elementary Thermomechanical Ice Sheet model) to simulate ice sheet response to abrupt perturbations in ocean and atmospheric temperature. The f.ETISh model is a vertically integrated hybrid (SSA/SIA) ice sheet model including ice shelves. Although vertically integrated, thermomechanical coupling is ensured through a simplified representation of ice sheet thermodynamics based on an analytical solution of the vertical temperature profile, including strain heating and horizontal advection. The marine boundary is represented by a flux condition either coherent with power-law basal sliding (Pollard & Deconto (2012) based on Schoof (2007)) or according to Coulomb basal friction (Tsai et al., 2015), both taking into account ice-shelf buttressing. Model initialization is based on optimization of the basal friction field. Besides the traditional MISMIP tests, new tests with respect to MISI in plan-view models have been devised. The model is forced with stepwise ocean and atmosphere temperature perturbations. The former is based on a parametrised sub-shelf melt (limited to ice shelves), while the latter is based on present-day mass balance/surface temperature and corrected for elevation changes. Surface melting is introduced using a PDD model. Results show a general linear response in mass loss to ocean warming. Nonlinear response due to MISI occurs under specific conditions and is highly sensitive to the basal conditions near the grounding line, governed by both the initial conditions and the basal sliding/deformation model. The Coulomb friction model leads to significantly higher

  10. An abrupt and prominent climatic reversal at 9.2 ka in the northeastern North America

    NASA Astrophysics Data System (ADS)

    Hou, J.; Huang, Y.; Shuman, B. N.; Oswald, W.; Foster, D. R.

    2008-12-01

    Continental climate during the early Holocene (from 10 to 7 ka) is characterized by multiple abrupt climatic reversals such as the well-known 8.2 ka event that has been observed worldwide and attributed to the terminal collapse of the Laurentide Ice Sheet (LIS) in the North American continent. However, many episodes of meltwater releases occurred prior to the final collapse of LIS, their impact on the continental climate is much less understood. We present in this paper decadal-scale hydrogen isotopic records of aquatic and terrestrial plant biomarkers from Blood Pond, Massachusetts during the early Holocene. Our isotopic records infer a cooling of 3~4 degree between 9.3 and 9.1 ka against the millennial scale climate background, mainly induced by changes in precipitation seasonality. In comparison, the 8.2 ka event displays smaller amplitude of temperature cooling of 1~2 degree at our southern New England site. We interpret our observed climatic reversal at ~ 9.2 ka as representing increased proportion of winter precipitation in conjunction with a drier and cooler summer, triggered by slowdown in thermohaline circulation as a result of freshwater release from the proglacial lakes. We attribute the difference in climate response at 8.2 ka and 9.2 ka events to the configuration of LIS, with 9.2 ka LIS having a much stronger blocking effect on the moisture from the Gulf of Mexico during the summer. Our data suggest that the seasonality of the precipitation at the southern New England was highly sensitive to meltwater releases, especially prior to the final collapse of the LIS.

  11. Distinct histopathology of acute onset or abrupt exacerbation of hypersensitivity pneumonitis.

    PubMed

    Hariri, Lida P; Mino-Kenudson, Mari; Shea, Barry; Digumarthy, Subba; Onozato, Maristela; Yagi, Yukako; Fraire, Armando E; Matsubara, Osamu; Mark, Eugene J

    2012-05-01

    Hypersensitivity pneumonitis is an inflammatory lung disease that develops in response to exposure to antigen. Cases can be stratified by the duration of exposure and speed of symptom progression into acute, subacute, and chronic hypersensitivity pneumonitis. Although the pathologic features of subacute hypersensitivity pneumonitis are well established and those of chronic hypersensitivity pneumonitis have been reported, little is known about the histopathology of acute hypersensitivity pneumonitis. We evaluated the pathologic features of 5 patients with clinically confirmed hypersensitivity pneumonitis and rapid onset of symptoms and 3 patients with subacute or chronic hypersensitivity pneumonitis with symptom exacerbation. Histopathologic features assessed in each case included those characteristic of subacute hypersensitivity pneumonitis (bronchiolocentric chronic inflammation, histiocytic aggregates, and bronchiolitis obliterans), those associated with acute inflammation (fibrin deposition and neutrophilic infiltrate), and fibrosis. The classic features of hypersensitivity pneumonitis were identified in all 8 cases, with 1 also exhibiting fixed fibrosis confirming underlying chronic hypersensitivity pneumonitis. Fibrin deposition was present in 8 (100%) of 8 cases, and its extent was significant (28% surface area fibrin deposition/total disease area on average). Two had intra-alveolar fibrin so marked that it resembled acute fibrinous and organizing pneumonia. In addition, prominent interstitial neutrophilic infiltrate (≥5 cells/high-power field) was seen in all cases. These features have not been reported as characteristics of subacute or chronic hypersensitivity pneumonitis. Increased fibrin deposition and neutrophilic infiltrate may characterize acute hypersensitivity pneumonitis or abrupt exacerbation of hypersensitivity pneumonitis, and these along with characteristic features of subacute hypersensitivity pneumonitis (granulomatous inflammation and

  12. Abrupt release of terrigenous organic carbon to the Laptev Sea at termination of the Younger Dryas

    NASA Astrophysics Data System (ADS)

    Tesi, T.; Muschitiello, F.; Smittenberg, R.; Jakobsson, M.; Vonk, J.; Hill, P.; Dudarev, O.; Semiletov, I. P.; Kirchner, N.; Noormets, R.; Andersson, A.; Gustafsson, O.

    2015-12-01

    Based on analysis of a piston core collected in 2014 from the Lena River paleo delta, now Laptev Sea, we show that rapid and massive organic carbon (OC) deposition took place into the marine system at the termination of the Younger Dryas when the Arctic region experienced a large and extremely fast climate change. The highly laminated strata with absence of bioturbation further confirm the rapid event-driven emplacement of this deposit which was largely dominated by terrigenous OC as indicated by depleted δ13C values and high concentrations of terrestrial fossil biomarkers (lignin phenols and cutin-derived products). Moreover, the hydrogen isotopic composition (δ2H) of HMW n-alkanes indicates that this terrestrially-derived translocated OC was produced in the watershed during a relatively cold period. The OC appears to be a few thousand years old at time of deposition (ca. 4-5000 radiocarbon years; reservoir age corrected), consistent with the radiocarbon age of pre-aged OC currently supplied by the Lena river. Altogether our results indicate that fast climate warming exerts first-order control on large-scale carbon redistribution. Because the Younger Dryas-Preboreal transition occurred within a few decades, we infer that the abrupt and large release of terrigenous OC was essentially driven by rapid changes in the permafrost stability (i.e., thermal collapse/thawing) and increase in precipitation over the Siberian watershed. Interestingly, only surface and sub-surface carbon pools (i.e., active layer) were remobilized while deep and old sources (radiocarbon dead) did not seem to have substantially contributed to the total land-to-ocean flux during the Younger Dryas-Preboreal transition.

  13. Placental genetic variations in circadian clock-related genes increase the risk of placental abruption

    PubMed Central

    Qiu, Chunfang; Gelaye, Bizu; Denis, Marie; Tadesse, Mahlet G; Enquobahrie, Daniel A; Ananth, Cande V; Pacora, Percy N; Salazar, Manuel; Sanchez, Sixto E; Williams, Michelle A

    2016-01-01

    The genetic architecture of placental abruption (PA) remains poorly understood. We examined variations in SNPs of circadian clock-related genes in placenta with PA risk. We also explored placental and maternal genomic contributions to PA risk. Placental genomic DNA samples were isolated from 280 PA cases and 244 controls. Genotyping was performed using the Illumina Cardio-MetaboChip. We examined 116 SNPs in 13 genes known to moderate circadian rhythms. Logistic regression models were fit to estimate odds ratios (ORs). The combined effect of multiple SNPs on PA risk was estimated using a weighted genetic risk score. We examined independent and joint associations of wGRS derived from placental and maternal genomes with PA. Seven SNPs in five genes (ARNTL2, CRY2, DEC1, PER3 and RORA), in the placental genome, were associated with PA risk. Each copy of the minor allele (G) of a SNP in the RORA gene (rs2899663) was associated with a 30% reduced odds of PA (95% CI 0.52-0.95). The odds of PA increased with increasing placental-wGRS (Ptrend<0.001). The ORs were 1.00, 2.16, 3.24 and 4.48 across quartiles. Associations persisted after the maternal-wGRS was included in the model. There was evidence of an additive contribution of placental and maternal genetic contributions to PA risk. Participants with placental- and maternal-wGRS in the highest quartile, compared with those in the lowest quartile, had a 15.57-fold (95% CI 3.34-72.60) increased odds of PA. Placental variants in circadian clock-related genes are associated with PA risk; and the association persists after control of genetic variants in the maternal genome. PMID:27186326

  14. Trend, abrupt change, and periodicity of streamflow in the mainstream of Yellow River.

    PubMed

    He, Bin; Miao, Chiyuan; Shi, Wen

    2013-07-01

    The Yellow River is the second largest river in China. The annual runoff of which is only about 2% of China's total, but contributes to 9% of China's GDP and directly supports 12% of the population. Today, the water shortage in the Yellow River basin has been aggravated due to rapid population growth and global warming. In order to best maximize water resources management, the natural and observed streamflow series from six hydrologic gauging stations (Guide, Lanzhou, Hekou, Sanmenxia, Huayuankou, and Lijin) are obtained, and the linear regression, Mann-Kendall test, and wavelet transform methods were used to detect the characteristic of streamflow variation from 1956 to 2007. The results show that: (1) both the natural streamflow and observed streamflow present a downward trend over the past 52 years, and the trends are intensified downstream; the decreasing rate of observed streamflow is more rapid than that of the natural streamflow; (2) most of the abrupt changes in natural streamflow and observed streamflow appear in the late 1980s to early 1990s through the result of the Mann-Kendall test; and (3) other than the Guide station, the streamflows at the rest of the stations appear to have strongest periodicity of 19-21 years with a 52-year scale. The results of this study imply that less precipitation and warmer climate in the basin are the primary factors that cause this decreasing trend of natural streamflow. Additionally, the rapid ascent of water consumption by human being results in the reduction of observed streamflow further. Furthermore, human activities like reservoir construction, soil and water conservation measures, etc. influence the streamflow as well. It is recommended that the society takes some effective countermeasures to cope with the water shortage.

  15. Dansgaard-Oeschger-like abrupt climate transition in a coupled GCM

    NASA Astrophysics Data System (ADS)

    Tziperman, E.; Eisenman, I.; Bitz, C.

    2006-12-01

    The last glaciation (80-10 kyr BP) was punctuated by dramatic switches between warm and cold climates characterized by abrupt warming events recorded in Greenland ice cores. A leading hypothesis attributes these Dansgaard-Oeschger (DO) events to internal variability in the North Atlantic meridional overturning circulation (MOC), but theories have struggled to explain how these changes in MOC are capable of inducing such a large signal in Greenland. We present the results of two simulations using the CCSM3 coupled atmosphere-ocean-sea ice model. Both simulations are forced by land ice distributions characteristic of periods midway between glacial and interglacial states, but one simulation is initialized with a warm interglacial ocean initial condition while the other has a cold glacial ocean initial condition. The main difference between the surface temperatures in the two simulations is the presence of a warm region covering southern Greenland and the Greenland and Norwegian Seas in the warm-initiated simulation. The simulations have differing MOC for about 700 years which appears to cause differences in sea ice cover leading to an annual mean temperature disparity of 10° C in southern Greenland, in agreement with proxy reconstructions of the temperature change associated with DO events. The cold-initiated simulation quickly adjusts to a fairly constant state characterized by weak MOC, large sea ice area, and cold Greenland temperature. In contrast to this, the warm-initiated simulation displays an initial excitation of the MOC amplitude which then decreases over the next several hundred years. At this point we reduce the CO2 by 15ppm to represent further evolution of a developing glaciation, after which the MOC grows and then gradually decreases again. These results provide falsifiable predictions regarding the regional and seasonal distribution of DO events which can be compared directly with proxy data.

  16. [Effects of abrupt salinity stress on osmoregulation of juvenile Rachycentron canadum].

    PubMed

    Xu, Li-Wen; Liu, Guang-Feng; Wang, Rui-Xuan; Su, You-Lu; Guo, Zhi-Xun; Feng, Juan

    2007-07-01

    Rachycentron canadum is a thriving mariculture species for offshore cage in southern Mainland and Taiwan of China, due to its rapid growth rate and high quality flesh. In this paper, the gill Na(+)-K+ ATPase (NKA) activity and iono- and osmoregulation of juvenile R. canadum were investigated in a 12 h stress of ambient salinities (0-45), and the results showed that after an abrupt transfer to the salinities of 0, 5, 15, 25, 37 (control) and 45, the death of juvenile R. canadum only occurred in salinity 0, with a mortality of 100% by the end of the experiment. In all treatments, the gill NKA activity and serum osmolality fluctuated in first 3 h, and then changed smoothly. The NKA activity varied with salinity grade in U shape, being significantly (P < 0.05) higher in salinity 5 and the lowest in salinity 15 in 12 h, while the serum osmolality (ranged 293-399 mOsmol x kg(-1)) presented a positive correlation with salinity. Serum [Na+] and [Cl-] concentration slightly increased with salinity within the period of 3-12 h, while serum [K+] displayed a reverse pattern. The isosmotic point was estimated as 328.2 mOsm x kg(-1) and corresponded to salinity 11.48. The isoionic points for serum [Na+], [K+] and [Cl-] were estimated as 155.2, 6.16, and 137.1 mmol x L(-1), which corresponded to the salinities of 10.68, 20.44 and 8.41, respectively. It was concluded that R. canadum could be characterized physiologically as a "higher-NKA-in-hyposmotic media" marine euryhaline teleost with the capability of rapid and effective hyper/hypo iono- and osmoregulation.

  17. Broadly targeted CD8+ T cell responses restricted by major histocompatibility complex E

    DOE PAGES

    Hansen, Scott G.; Wu, Helen L.; Burwits, Benjamin J.; Hughes, Colette M.; Hammond, Katherine B.; Ventura, Abigail B.; Reed, Jason S.; Gilbride, Roxanne M.; Ainslie, Emily; Morrow, David W.; et al

    2016-02-12

    Major histocompatibility complex (MHC)-E is a highly conserved, ubiquitously expressed, nonclassical, MHC-Ib molecule with limited polymorphism primarily involved in regulation of NK cell reactivity via interaction with NKG2/CD94 receptors. We found that vaccination of rhesus macaques with Rh157.5/.4 gene-deleted rhesus Cytomegalovirus (RhCMV) vectors uniquely diverts MHC-E function to presentation of highly diverse peptide epitopes to CD8α/β+ T cells, approximately 4 distinct epitopes per 100 amino acids, in all tested protein antigens. Computational structural analysis revealed that a relatively stable, open binding groove in MHC-E attains broad peptide binding specificity by imposing a similar backbone configuration on bound peptides with fewmore » restrictions based on amino acid side chains. Since MHC-E is up-regulated on cells infected with HIV/SIV and other persistent viruses to evade NK cell activity, MHC-E-restricted CD8+ T cell responses have the potential to exploit pathogen immune evasion adaptations, a capability that might endow these unconventional responses with superior efficacy.« less

  18. Use of uterine artery embolization to prevent peripartum hemorrhage of placental abruption with fetal demise & severe DIC.

    PubMed

    Latif, E; Adam, S; Rungruang, B; Al-Hendy, A; Diamond, M P; Rotem, E; Cannell, J; Browne, P C

    2016-09-16

    Uterine artery embolization (UAE) is typically not indicated in the pre-operative management of pregnancies with a live fetus, because risk of fetal death from reduced uteroplacental blood flow. However, pre-operative UAE in pregnancies with a fetal demise poses no fetal risk, and may offer maternal benefits. Patients with placental abruption resulting in fetal demise are at high-risk for developing disseminated intravascular coagulation (DIC), which could have devastating complications such as peri-operative hemorrhage and death. This case report describes the first successful execution of a pre-operative UAE that effectively prevented antepartum and postpartum hemorrhage in a patient with DIC secondary to a placental abruption and recent fetal demise. PMID:27589544

  19. Spontaneous Early Recanalization after Acute Innominate Artery Thromboembolic Occlusion Secondary to Abrupt Aspirin and Statin Discontinuation A Case Report

    PubMed Central

    Tsai, C-K; Lee, J-T; Wu, Y-C; Peng, G-S

    2014-01-01

    ABSTRACT Statin and antiplatelet drugs are widely used for prevention of ischaemic stroke and other cardiovascular diseases in high-risk patients. We report a rare case of a 49-year old man with a history of myocardial infarction and hyperlipidaemia who suffered an acute occlusion of his innominate artery (IA) accompanied by subclavian steal syndrome and cerebral infarction, on day seven after abrupt cessation of aspirin and statin, as confirmed by magnetic resonance and computed tomographic angiography of head and neck, and colour-coded Duplex ultrasonography (CCDU). Aspirin and atorvastatin were immediately re-started on admission. Spontaneous recanalization of IA was shown on repeat CCDU and digital subtraction angiography on day 10 after stroke onset. This case serves as a reminder that abrupt discontinuation of both aspirin and statin in patients with previous history of cardiovascular disease may increase the risk of ischaemic stroke. PMID:25781297

  20. Spontaneous abrupt climate change due to an atmospheric blocking-sea-ice-ocean feedback in an unforced climate model simulation.

    PubMed

    Drijfhout, Sybren; Gleeson, Emily; Dijkstra, Henk A; Livina, Valerie

    2013-12-01

    Abrupt climate change is abundant in geological records, but climate models rarely have been able to simulate such events in response to realistic forcing. Here we report on a spontaneous abrupt cooling event, lasting for more than a century, with a temperature anomaly similar to that of the Little Ice Age. The event was simulated in the preindustrial control run of a high-resolution climate model, without imposing external perturbations. Initial cooling started with a period of enhanced atmospheric blocking over the eastern subpolar gyre. In response, a southward progression of the sea-ice margin occurred, and the sea-level pressure anomaly was locked to the sea-ice margin through thermal forcing. The cold-core high steered more cold air to the area, reinforcing the sea-ice concentration anomaly east of Greenland. The sea-ice surplus was carried southward by ocean currents around the tip of Greenland. South of 70 °N, sea ice already started melting and the associated freshwater anomaly was carried to the Labrador Sea, shutting off deep convection. There, surface waters were exposed longer to atmospheric cooling and sea surface temperature dropped, causing an even larger thermally forced high above the Labrador Sea. In consequence, east of Greenland, anomalous winds changed from north to south, terminating the event with similar abruptness to its onset. Our results imply that only climate models that possess sufficient resolution to correctly represent atmospheric blocking, in combination with a sensitive sea-ice model, are able to simulate this kind of abrupt climate change.

  1. Spontaneous abrupt climate change due to an atmospheric blocking-sea-ice-ocean feedback in an unforced climate model simulation.

    PubMed

    Drijfhout, Sybren; Gleeson, Emily; Dijkstra, Henk A; Livina, Valerie

    2013-12-01

    Abrupt climate change is abundant in geological records, but climate models rarely have been able to simulate such events in response to realistic forcing. Here we report on a spontaneous abrupt cooling event, lasting for more than a century, with a temperature anomaly similar to that of the Little Ice Age. The event was simulated in the preindustrial control run of a high-resolution climate model, without imposing external perturbations. Initial cooling started with a period of enhanced atmospheric blocking over the eastern subpolar gyre. In response, a southward progression of the sea-ice margin occurred, and the sea-level pressure anomaly was locked to the sea-ice margin through thermal forcing. The cold-core high steered more cold air to the area, reinforcing the sea-ice concentration anomaly east of Greenland. The sea-ice surplus was carried southward by ocean currents around the tip of Greenland. South of 70 °N, sea ice already started melting and the associated freshwater anomaly was carried to the Labrador Sea, shutting off deep convection. There, surface waters were exposed longer to atmospheric cooling and sea surface temperature dropped, causing an even larger thermally forced high above the Labrador Sea. In consequence, east of Greenland, anomalous winds changed from north to south, terminating the event with similar abruptness to its onset. Our results imply that only climate models that possess sufficient resolution to correctly represent atmospheric blocking, in combination with a sensitive sea-ice model, are able to simulate this kind of abrupt climate change. PMID:24248352

  2. Spontaneous abrupt climate change due to an atmospheric blocking–sea-ice–ocean feedback in an unforced climate model simulation

    PubMed Central

    Drijfhout, Sybren; Gleeson, Emily; Dijkstra, Henk A.; Livina, Valerie

    2013-01-01

    Abrupt climate change is abundant in geological records, but climate models rarely have been able to simulate such events in response to realistic forcing. Here we report on a spontaneous abrupt cooling event, lasting for more than a century, with a temperature anomaly similar to that of the Little Ice Age. The event was simulated in the preindustrial control run of a high-resolution climate model, without imposing external perturbations. Initial cooling started with a period of enhanced atmospheric blocking over the eastern subpolar gyre. In response, a southward progression of the sea-ice margin occurred, and the sea-level pressure anomaly was locked to the sea-ice margin through thermal forcing. The cold-core high steered more cold air to the area, reinforcing the sea-ice concentration anomaly east of Greenland. The sea-ice surplus was carried southward by ocean currents around the tip of Greenland. South of 70°N, sea ice already started melting and the associated freshwater anomaly was carried to the Labrador Sea, shutting off deep convection. There, surface waters were exposed longer to atmospheric cooling and sea surface temperature dropped, causing an even larger thermally forced high above the Labrador Sea. In consequence, east of Greenland, anomalous winds changed from north to south, terminating the event with similar abruptness to its onset. Our results imply that only climate models that possess sufficient resolution to correctly represent atmospheric blocking, in combination with a sensitive sea-ice model, are able to simulate this kind of abrupt climate change. PMID:24248352

  3. Randomized, Double-Blinded Trial of Magnesium Sulfate Tocolysis versus Intravenous Normal Saline for Preterm Nonsevere Placental Abruption.

    PubMed

    Colón, Iris; Berletti, Monica; Garabedian, Matthew J; Wilcox, Nicole; Williams, Kristin; El-Sayed, Yasser Y; Chueh, Jane

    2016-06-01

    Objective To evaluate the efficacy and safety of magnesium sulfate in the resolution of vaginal bleeding and contractions in nonsevere placental abruption. Study Design Thirty women between 24 and 34 weeks of gestation diagnosed with nonsevere placental abruption were randomized to receive magnesium sulfate tocolysis or normal saline infusion. The primary outcome was the proportion of women undelivered at 48 hours with resolution of vaginal bleeding and uterine contractions. Maternal and neonatal outcomes were also compared. Results Fifteen (50%) women received magnesium sulfate tocolysis and 15 (50%) received intravenous saline. There was no difference in the number of women who were undelivered at 48 hours with resolution of vaginal bleeding and contractions in the magnesium sulfate (80.0%) and saline (66.7%; p-value = 0.68) groups. There were no differences between groups in the gestational age at randomization, time to uterine quiescence, time on study drug, length of hospitalization, days from randomization to delivery, incidence of side effects, or admissions to the neonatal intensive care unit. Conclusions Magnesium sulfate tocolysis did not provide a significant difference in pregnancy prolongation in the management of preterm nonsevere placental abruption. Recruitment goals were not met due to the introduction of the use of magnesium sulfate for neuroprotection.

  4. Reducing abrupt climate change risk using the Montreal Protocol and other regulatory actions to complement cuts in CO2 emissions.

    PubMed

    Molina, Mario; Zaelke, Durwood; Sarma, K Madhava; Andersen, Stephen O; Ramanathan, Veerabhadran; Kaniaru, Donald

    2009-12-01

    Current emissions of anthropogenic greenhouse gases (GHGs) have already committed the planet to an increase in average surface temperature by the end of the century that may be above the critical threshold for tipping elements of the climate system into abrupt change with potentially irreversible and unmanageable consequences. This would mean that the climate system is close to entering if not already within the zone of "dangerous anthropogenic interference" (DAI). Scientific and policy literature refers to the need for "early," "urgent," "rapid," and "fast-action" mitigation to help avoid DAI and abrupt climate changes. We define "fast-action" to include regulatory measures that can begin within 2-3 years, be substantially implemented in 5-10 years, and produce a climate response within decades. We discuss strategies for short-lived non-CO(2) GHGs and particles, where existing agreements can be used to accomplish mitigation objectives. Policy makers can amend the Montreal Protocol to phase down the production and consumption of hydrofluorocarbons (HFCs) with high global warming potential. Other fast-action strategies can reduce emissions of black carbon particles and precursor gases that lead to ozone formation in the lower atmosphere, and increase biosequestration, including through biochar. These and other fast-action strategies may reduce the risk of abrupt climate change in the next few decades by complementing cuts in CO(2) emissions.

  5. Reducing abrupt climate change risk using the Montreal Protocol and other regulatory actions to complement cuts in CO2 emissions

    PubMed Central

    Molina, Mario; Zaelke, Durwood; Sarma, K. Madhava; Andersen, Stephen O.; Ramanathan, Veerabhadran; Kaniaru, Donald

    2009-01-01

    Current emissions of anthropogenic greenhouse gases (GHGs) have already committed the planet to an increase in average surface temperature by the end of the century that may be above the critical threshold for tipping elements of the climate system into abrupt change with potentially irreversible and unmanageable consequences. This would mean that the climate system is close to entering if not already within the zone of “dangerous anthropogenic interference” (DAI). Scientific and policy literature refers to the need for “early,” “urgent,” “rapid,” and “fast-action” mitigation to help avoid DAI and abrupt climate changes. We define “fast-action” to include regulatory measures that can begin within 2–3 years, be substantially implemented in 5–10 years, and produce a climate response within decades. We discuss strategies for short-lived non-CO2 GHGs and particles, where existing agreements can be used to accomplish mitigation objectives. Policy makers can amend the Montreal Protocol to phase down the production and consumption of hydrofluorocarbons (HFCs) with high global warming potential. Other fast-action strategies can reduce emissions of black carbon particles and precursor gases that lead to ozone formation in the lower atmosphere, and increase biosequestration, including through biochar. These and other fast-action strategies may reduce the risk of abrupt climate change in the next few decades by complementing cuts in CO2 emissions. PMID:19822751

  6. A novel method for detecting abrupt dynamic change based on the changing Hurst exponent of spatial images

    NASA Astrophysics Data System (ADS)

    He, Wen-Ping; Liu, Qun-Qun; Gu, Bin; Zhao, Shan-Shan

    2016-10-01

    The climate system is a classical spatiotemporal evolutionary dynamic system with spatiotemporal correlation characteristics. Based on this, two-dimensional detrended fluctuation analysis (TD-DFA) is used to estimate the Hurst exponent of two-dimensional images. Then, we monitored the change of the Hurst exponent of the images to identify an abrupt dynamic change. We tested the performance of this method with a coupled spatiotemporal dynamic model and found that it works well. The changes in the Hurst exponents of the spatial images are stable when there is no dynamic change in the system, but there will be a clear non-stationary change of the Hurst exponents; for example, the abrupt mean values change if the dynamics of the system change. Thus, the TD-DFA method is suitable for detecting an abrupt dynamic change from natural and artificial images. The spatial images of the NCEP reanalysis of the daily average temperature exhibited fractality. Based on this, we found three non-stationary changes in the Hurst exponents for the NCEP reanalysis of the daily average temperature or for the annual average temperature in the region (60°S-60°N). It can be concluded that the climate system may have incurred three dynamic changes since 1961 on decadal timescales, i.e., in approximately the mid-1970s, the mid-1980s, and between the late 1990s and the early 2000s.

  7. Gradual versus abrupt weaning from respiratory support in acute respiratory failure and advanced chronic obstructive lung disease.

    PubMed

    Ashutosh, K

    1983-10-01

    Two methods of weaning from mechanical ventilation were compared in 18 instances of acute respiratory failure requiring mechanical ventilation for more than 30 days in patients with advanced chronic obstructive lung disease. All patients were ventilated using intermittent mandatory ventilation. Abrupt weaning (AW) consisted of abruptly discontinuing mechanical ventilation when the patients were considered ready for unassisted breathing. Gradual weaning (GW) involved a gradual reduction in the rate of intermittent mandatory ventilation before starting unassisted breathing. Gradual or abrupt weaning alone was used for weaning in five and four instances, respectively. Both methods were used in nine other instances. In the 14 instances when GW was tried, weaning was successful in three. In the 13 instances when AW was tried, weaning was successful in nine. The time in which mechanical ventilation was required was 64 +/- 31 (SD) days with GW and 42 +/- 12 (SD) days with AW. There was no difference in age, pulmonary function, or arterial blood gas results between the patients being weaned by the different methods. I conclude that GW offers no advantage over AW in weaning patients with advanced chronic obstructive lung disease requiring prolonged mechanical ventilation.

  8. A two-dimensional ion kinetic model of the scrape-off layer of a diverted plasma with a private flux region

    SciTech Connect

    Catto, P.J. ); Connor, J.W. , Culham, Abingdon, Oxfordshire, OX143DB )

    1995-01-01

    Earlier two-dimensional (radial and poloidal angle), analytically tractable ion kinetic models of the scrape-off layer (SOL) in which a steady state is achieved by balancing the streaming loss of ions to the divertor target plates with the radial diffusion of ions from the core are unable to distinguish between limited and diverted plasmas. The model presented here removes this limitation while still remaining amenable to a similar Wiener--Hopf solution procedure. To phenomenologically model ion recycling, the boundary conditions employed at the divertor plates allow for partial reflection. The diffusion into the private flux region and the extended divertor channels (all of normalized length [ital d] along the magnetic field), as well as the rest of the SOL, is evaluated. The SOL is shown to be asymmetric about the separatrix because ions from the core must stream by the X point be- fore diffusing into the private flux region. The channel or leg SOL width is of order [[ital LD](1+2[ital d])/[ital v][sub [ital i

  9. Hemodynamic Changes Caused by Flow Diverters in Rabbit Aneurysm Models: Comparison of Virtual and Realistic FD Deployments Based on Micro-CT Reconstruction.

    PubMed

    Xu, Jinyu; Deng, Benqiang; Fang, Yibin; Yu, Ying; Cheng, Jiyong; Wang, Shengzhang; Wang, Kuizhong; Liu, Jian-Min; Huang, Qinghai

    2013-01-01

    Adjusting hemodynamics via flow diverter (FD) implantation is emerging as a novel method of treating cerebral aneurysms. However, most previous FD-related hemodynamic studies were based on virtual FD deployment, which may produce different hemodynamic outcomes than realistic (in vivo) FD deployment. We compared hemodynamics between virtual FD and realistic FD deployments in rabbit aneurysm models using computational fluid dynamics (CFD) simulations. FDs were implanted for aneurysms in 14 rabbits. Vascular models based on rabbit-specific angiograms were reconstructed for CFD studies. Real FD configurations were reconstructed based on micro-CT scans after sacrifice, while virtual FD configurations were constructed with SolidWorks software. Hemodynamic parameters before and after FD deployment were analyzed. According to the metal coverage (MC) of implanted FDs calculated based on micro-CT reconstruction, 14 rabbits were divided into two groups (A, MC >35%; B, MC <35%). Normalized mean wall shear stress (WSS), relative residence time (RRT), inflow velocity, and inflow volume in Group A were significantly different (P<0.05) from virtual FD deployment, but pressure was not (P>0.05). The normalized mean WSS in Group A after realistic FD implantation was significantly lower than that of Group B. All parameters in Group B exhibited no significant difference between realistic and virtual FDs. This study confirmed MC-correlated differences in hemodynamic parameters between realistic and virtual FD deployment.

  10. Small pipes: preliminary experience with 3-mm or smaller pipeline flow-diverting stents for aneurysm repair prior to regulatory approval.

    PubMed

    Martin, A R; Cruz, J P; O'Kelly, C; Kelly, M; Spears, J; Marotta, T R

    2015-03-01

    Flow diversion has become an established treatment option for challenging intracranial aneurysms. The use of small devices of ≤3-mm diameter remains unapproved by major regulatory bodies. A retrospective review of patients treated with Pipeline Embolization Devices of ≤3-mm diameter at 3 Canadian institutions was conducted. Clinical and radiologic follow-up data were collected and reported. Twelve cases were treated with ≥1 Pipeline Embolization Device of ≤3-mm diameter, including 2 with adjunctive coiling, with a median follow-up of 18 months (range, 4-42 months). One patient experienced a posttreatment minor complication (8%) due to an embolic infarct. No posttreatment hemorrhage or delayed complications such as in-stent stenosis/thrombosis were observed. Radiologic occlusion was seen in 9/12 cases (75%) and near-occlusion in 2/12 cases (17%). Intracranial aneurysm treatment with small-diameter flow-diverting stents provided safe and effective aneurysm closure in this small selected sample. These devices should be further studied and considered for regulatory approval. PMID:25395659

  11. Hyperglycemia Diverts Dividing Osteoblastic Precursor Cells to an Adipogenic Pathway and Induces Synthesis of a Hyaluronan Matrix That Is Adhesive for Monocytes*

    PubMed Central

    Wang, Aimin; Midura, Ronald J.; Vasanji, Amit; Wang, Andrew J.; Hascall, Vincent C.

    2014-01-01

    Isolated rat bone marrow stromal cells cultured in osteogenic medium in which the normal 5.6 mm glucose is changed to hyperglycemic 25.6 mm glucose greatly increase lipid formation between 21–31 days of culture that is associated with decreased biomineralization, up-regulate expression of cyclin D3 and two adipogenic markers (CCAAT/enhancer binding protein α and peroxisome proliferator-activated receptor γ) within 5 days of culture, increase neutral and polar lipid synthesis within 5 days of culture, and form a monocyte-adhesive hyaluronan matrix through an endoplasmic reticulum stress-induced autophagic mechanism. Evidence is also provided that, by 4 weeks after diabetes onset in the streptozotocin-induced diabetic rat model, there is a large loss of trabecular bone mineral density without apparent proportional changes in underlying collagen matrices, a large accumulation of a hyaluronan matrix within the trabecular bone marrow, and adipocytes and macrophages embedded in this hyaluronan matrix. These results support the hypothesis that hyperglycemia in bone marrow diverts dividing osteoblastic precursor cells (bone marrow stromal cells) to a metabolically stressed adipogenic pathway that induces synthesis of a hyaluronan matrix that recruits inflammatory cells and establishes a chronic inflammatory process that demineralizes trabecular cancellous bone. PMID:24569987

  12. REBASE - restriction enzymes and methylases.

    PubMed Central

    Roberts, R J; Macelis, D

    1998-01-01

    REBASE is a comprehensive database of information about restriction enzymes and their associated methylases, including their recognition and cleavage sites and their commercial availability. Also included is a listing of homing endonucleases. Information from REBASE is available via monthly electronic mailings as well as via anonymous ftp and through the World Wide Web. The REBASE web site, http://www. neb.com/rebase , is where we maintain a web page for every enzyme, reference and supplier. Additionally, there is a search facility, help and NEWS pages, and a complete description of our various services. Specialized files are available that can be used directly by many software packages. PMID:9399870

  13. Modeling past abrupt climate changes: driven oscillators and synchronization phenomena in Paleoclimate theory

    NASA Astrophysics Data System (ADS)

    Marchionne, Arianna

    2014-05-01

    According to Milankovitch theory of ice ages, summer insolation at high northern latitudes drives the glacial cycles, i.e. the growth and reduction of Northern Hemisphere ice sheets, and there is evidence that astronomical forcing controls indeed the timing of Pleistocene glacial-interglacial cycles. However, the δ18Otime series (the δ18O is a proxy for global ice volume) available for the last few million years reveal a non-linear response of the climate to the external forcing: transitions from the glacial to the interglacial states occur more rapidly than the transitions from the interglacials to the glacials, resulting in the so-called saw-tooth shape of the signal. These terminations were very abrupt compared to the smooth changes in insolation. Moreover, insolation alone cannot explain the Mid-Pleistocene transition. During this event, occurred about one million years ago, the dominant 41 kyr glacial cycles, were replaced by longer saw-tooth shaped cycles with a time scale around 100 kyr. The asymmetry in the oscillations indicates a non-linear response to the orbital forcing, expressed through a bifurcation, or tipping point. As an introduction to the problem, we studied simple driven oscillators that can exhibit asymmetric oscillations between the glacial and interglacial states under the effect of the astronomical forcing, such as the Van der Pool and the Duffing oscillators. In order to understand how these simple low-dimensional models enter theories of ice ages and rapid events, we studied synchronization phenomena between simple driven oscillators and astronomical forcing, focusing on distinguishing between the so-called resonance scenario and the so-called phase locking scenario. We next examined the possible mechanisms for the Mid-Pleistocene transition. Here we show that the transition could be explained as a result of frequency-locking to the external forcing. This change can be interpreted as a result of an internal change in climate response

  14. Abrupt transitions during sustained explosive eruptions: Examples from the 1912 eruption of Novarupta, Alaska

    USGS Publications Warehouse

    Adams, N.K.; Houghton, B.F.; Hildreth, W.

    2006-01-01

    Plinian/ignimbrite activity stopped briefly and abruptly 16 and 45 h after commencement of the 1912 Novarupta eruption defining three episodes of explosive volcanism before finally giving way after 60 h to effusion of lava domes. We focus here on the processes leading to the termination of the second and third of these three episodes. Early erupted pumice from both episodes show a very similar range in bulk vesicularity, but the modal values markedly decrease and the vesicularity range widens toward the end of Episode III. Clasts erupted at the end of each episode represent textural extremes; at the end of Episode II, clasts have very thin glass walls and a predominance of large bubbles, whereas at the end of Episode III, clasts have thick interstices and more small bubbles. Quantitatively, all clasts have very similar vesicle size distributions which show a division in the bubble population at 30 ??m vesicle diameter and cumulative number densities ranging from 107-109 cm-3. Patterns seen in histograms of volume fraction and the trends in the vesicle size data can be explained by coalescence signatures superimposed on an interval of prolonged nucleation and free growth of bubbles. Compared to experimental data for bubble growth in silicic melts, the high 1912 number densities suggest homogeneous nucleation was a significant if not dominant mechanism of bubble nucleation in the dacitic magma. The most distinct clast populations occurred toward the end of Plinian activity preceding effusive dome growth. Distributions skewed toward small sizes, thick walls, and teardrop vesicle shapes are indicative of bubble wall collapse marking maturation of the melt and onset of processes of outgassing. The data suggest that the superficially similar pauses in the 1912 eruption which marked the ends of episodes II and III had very different causes. Through Episode III, the trend in vesicle size data reflects a progressive shift in the degassing process from rapid magma ascent and

  15. Transient Adjustment of the global climate to an abrupt Northern North Atlantic cooling

    NASA Astrophysics Data System (ADS)

    Tang, G.; Chang, P.; Panetta, R.; Saravanan, R.

    2013-12-01

    The Thermohaline Circulation (THC) is thought to play a key role in abrupt changes in Earth climate. In cold periods such as the Younger Dryas, the THC was much weaker than today. In an experiment with a fully coupled CCSM3 model an artificial freshwater flux is added to the Northern North Atlantic Ocean surface, which weakens the THC. The North Atlantic Ocean surface cools almost instantly after the freshwater flux onset. This cooling is subsequently spread throughout the Northern Hemisphere, resulting in the ITCZ moving southward. In the weakening THC, heat carried by the THC from Southern Hemisphere to the Northern Hemisphere is reduced, resulting in a cooler Northern Hemisphere. It is still questioned what role the atmosphere plays in this process. There are two possible ways the atmosphere may change the ocean surface temperature. One is that the wind changes the ocean surface wind-driven circulation, leading to a change to the ocean heat budget. Another is that the atmosphere changes the ocean-atmosphere heat flux directly. Here we look into the second possibility by comparing the effects of freshwater flux in a fully coupled model to the effects of the same flux in a model constructed by coupling an atmospheric general circulation model (CAM3) to a thermodynamic slab ocean model. With use of appropriate Q-fluxes, the coupled model with the slab ocean has the same climatology as the fully coupled CCSM3 model. Perturbation Q-fluxes are constructed for the fresh water flux experiments using a restoring technique. We find that the atmosphere interacting with a thermodynamic slab ocean can spread the cooling from the Northern North Atlantic and cause the ITCZ to move southward, and that there is a cooling front propagating southward with a speed depending on the mixed layer depth: a deeper mixed layer depth results in a slower propagation. By applying the Q-flux perturbation only in the Northern North Atlantic Ocean, the effect of the ocean circulation change on

  16. The Paleoceanography of Cariaco Basin and its Relationship to Deglacial and Abrupt Climate Change

    NASA Astrophysics Data System (ADS)

    Peterson, L. C.; Yurco, L. N.; Gibson, K.; Haug, G. H.; Deplazes, G.; Black, D. E.; Thunell, R.

    2011-12-01

    wet interval in the northern tropics of South America that falls within the enigmatic Late Glacial period known as the "Mystery Interval". Spanning the Bølling/Allerød and Younger Dryas, an abrupt pulse of biogenic opal accumulation is observed that may reflect advection of silica-rich deep waters to the surface as a result of deep water reorganization. Though Cariaco sea surface temperatures appear to mimic changes in Greenland, oxygen isotopes in planktic foraminifers closely resemble Antarctic air temperature records during the deglaciation, suggesting that a complex mixture of hemispheric signals is preserved in the southern Caribbean.

  17. Abrupt shifts in ecosystem function and intensification of global biogeochemical cycle driven by hydroclimatic extremes

    NASA Astrophysics Data System (ADS)

    Ma, Xuanlong; Huete, Alfredo; Ponce-Campos, Guillermo; Zhang, Yongguang; Xie, Zunyi; Giovannini, Leandro; Cleverly, James; Eamus, Derek

    2016-04-01

    Amplification of the hydrologic cycle as a consequence of global warming is increasing the frequency, intensity, and spatial extent of extreme climate events globally. The potential influences resulting from amplification of the hydro-climatic cycle, coupled with an accelerating warming trend, pose great concerns on the sustainability of terrestrial ecosystems to sequester carbon, maintain biodiversity, provide ecosystem services, food security, and support human livelihood. Despite the great implications, the magnitude, direction, and carry-over effect of these extreme climate events on ecosystem function, remain largely uncertain. To address these pressing issues, we conducted an observational, interdisciplinary study using satellite retrievals of atmospheric CO2 and photosynthesis (chlorophyll fluorescence), and in-situ flux tower measures of ecosystem-atmosphere carbon exchange, to reveal the shifts in ecosystem function across extreme drought and wet periods. We further determine the factors that govern ecosystem sensitivity to hydroclimatic extremes. We focus on Australia but extended our analyses to other global dryland regions due to their significant role in global biogeochemical cycles. Our results revealed dramatic impacts of drought and wet hydroclimatic extremes on ecosystem function, with abrupt changes in vegetation productivity, carbon uptake, and water-use-efficiency between years. Drought resulted in widespread reductions or collapse in the normal patterns of vegetation growth seasonality such that in many cases there was no detectable phenological cycle during extreme drought years. We further identified a significant increasing trend (p < 0.001) in extreme wet year precipitation amounts over Australia and many other global regions, resulting in an increasing trend in magnitude of the episodic carbon sink pulses coupled to each La Niña-induced wet years. This finding is of global biogeochemical significance, with the consequence of amplifying

  18. Abrupt Climate Change Caused by Global Fires from a Large Meteor Impact

    NASA Astrophysics Data System (ADS)

    Bardeen, C.; Toon, O. B.; Garcia, R. R.; Otto-Bliesner, B. L.; Wolf, E. T.

    2015-12-01

    Global or near-global fires like those that are thought to have occurred after the Chicxulub asteroid impact are associated with abrupt climate change and the K-Pg mass extinction event. Using the Community Earth System Model (CESM), a three-dimensional coupled climate model with interactive chemistry, we have simulated the climate response to global fires assuming a burden of 70,000 Tg, as estimated from the K-Pg layer sediments by Wolbach et al. (1988). Soot aerosols are lofted by solar heating and remain in the atmosphere for about 6 years, warming the stratosphere by more than 240 K and suppressing completely solar radiation at the surface for 2 years. Global average land surface temperatures cool by -28 K after 3 years and ocean temperatures by -11 K after 4 years. Precipitation is reduced by 80 % for 5 years, and the ozone column is reduced by 80 % for 4 years. The tropical tropopause cold point disappears for a few years, leading to water vapor mixing ratios of > 1000 ppmv in the stratosphere. There is a rapid recovery around year 6, when the soot is removed by wet deposition as stratospheric water condenses and precipitates, but this is followed by a peak in the UV Index in the tropics of over 40 before stratospheric ozone recovers. Ocean temperature cools by more than -2 K to a depth of 300 m, and sea ice develops in the Black Sea, Caspian Sea, and Baltic Sea. Global fires, two years of darkness, extreme surface cooling, significant ocean cooling, increases in sea ice extent and a large short-term increase in UV Index would have been catastrophic for many life forms. This work is the first step in an effort to simulate the climatic effects of all of the aerosols and gases that may have been generated by the Chicxulub impact in a model that has been configured for late-Cretaceous conditions to help assess the role of the Chicxulub impact in the K-Pg extinction.

  19. Abrupt summer warming and changes in temperature extremes over Northeast Asia since the mid-1990s: Drivers and physical processes

    NASA Astrophysics Data System (ADS)

    Dong, Buwen; Sutton, Rowan T.; Chen, Wei; Liu, Xiaodong; Lu, Riyu; Sun, Ying

    2016-09-01

    This study investigated the drivers and physical processes for the abrupt decadal summer surface warming and increases in hot temperature extremes that occurred over Northeast Asia in the mid-1990s. Observations indicate an abrupt increase in summer mean surface air temperature (SAT) over Northeast Asia since the mid-1990s. Accompanying this abrupt surface warming, significant changes in some temperature extremes, characterized by increases in summer mean daily maximum temperature (Tmax), daily minimum temperature (Tmin), annual hottest day temperature (TXx), and annual warmest night temperature (TNx) were observed. There were also increases in the frequency of summer days (SU) and tropical nights (TR). Atmospheric general circulation model experiments forced by changes in sea surface temperature (SST)/sea ice extent (SIE), anthropogenic greenhouse gas (GHG) concentrations, and anthropogenic aerosol (AA) forcing, relative to the period 1964-93, reproduced the general patterns of observed summer mean SAT changes and associated changes in temperature extremes, although the abrupt decrease in precipitation since the mid-1990s was not simulated. Additional model experiments with different forcings indicated that changes in SST/SIE explained 76% of the area-averaged summer mean surface warming signal over Northeast Asia, while the direct impact of changes in GHG and AA explained the remaining 24% of the surface warming signal. Analysis of physical processes indicated that the direct impact of the changes in AA (through aerosol-radiation and aerosol-cloud interactions), mainly related to the reduction of AA precursor emissions over Europe, played a dominant role in the increase in TXx and a similarly important role as SST/SIE changes in the increase in the frequency of SU over Northeast Asia via AA-induced coupled atmosphere-land surface and cloud feedbacks, rather than through a direct impact of AA changes on cloud condensation nuclei. The modelling results also imply

  20. 9 CFR 78.20 - General restrictions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... INTERSTATE TRANSPORTATION OF ANIMALS (INCLUDING POULTRY) AND ANIMAL PRODUCTS BRUCELLOSIS Restrictions on Interstate Movement of Bison Because of Brucellosis § 78.20 General restrictions. Bison may not be...