Narrow absorption lines with two observations from the Sloan Digital Sky Survey

NASA Astrophysics Data System (ADS)

Chen, Zhi-Fu; Gu, Qiu-Sheng; Chen, Yan-Mei; Cao, Yue

2015-07-01

We assemble 3524 quasars from the Sloan Digital Sky Survey (SDSS) with repeated observations to search for variations of the narrow C IV λ λ 1548,1551 and Mg II λ λ 2796,2803 absorption doublets in spectral regions shortward of 7000 Å in the observed frame, which corresponds to time-scales of about 150-2643 d in the quasar rest frame. In these quasar spectra, we detect 3580 C IV absorption systems with zabs = 1.5188-3.5212 and 1809 Mg II absorption systems with zabs = 0.3948-1.7167. In term of the absorber velocity (β) distribution in the quasar rest frame, we find a substantial number of C IV absorbers with β < 0.06, which might be connected to absorption of quasar outflows. The outflow absorption peaks at υ ≈ 2000 km s^{-1} and drops rapidly below this peak value. Among 3580 C IV absorption systems, 52 systems (˜1.5 per cent) show obvious variations in equivalent widths in the absorber rest frame (Wr): 16 enhanced, 16 emerged, 12 weakened and 8 disappeared systems, respectively. We find that changes in Wrλ1548 are related neither to the time-scales of the two SDSS observations nor to absorber velocities in the quasar rest frame. Variable absorption in low-ionization species is important to constrain the physical conditions of the absorbing gas. There are two variable Mg II absorption systems measured from SDSS spectra detected by Hacker et al. However, in our Mg II absorption sample, we find that neither shows variable absorption with confident levels of >4σ for λ2796 lines and >3σ for λ2803 lines.

Stationary hydrodynamic models of Wolf-Rayet stars with optically thick winds.

NASA Astrophysics Data System (ADS)

Heger, A.; Langer, N.

1996-11-01

We investigate the influence of a grey, optically thick wind on the surface and internal structure of Wolf-Rayet (WR) stars. We calculate hydrodynamic models of chemically homogeneous helium stars with stationary outflows, solving the full set of stellar structure equations from the stellar center up to well beyond the sonic point of the wind, including the line force originating from absorption lines in a parameterized way. For specific assumptions about mass loss rate and wind opacity above our outer boundary, we find that the iron opacity peak may lead to local super-Eddington luminosities at the sonic point. By varying the stellar wind parameters over the whole physically plausible range, we show that the radius of the sonic point of the wind flow is always very close to the hydrostatic stellar radius obtained in WR star models which ignore the wind. However, our models confirm the possibility of large values for observable WR radii and correspondingly small effective temperatures found in earlier models. We show further that the energy which is contained in a typical WR wind can not be neglected. The stellar luminosity may be reduced by several 10%, which has a pronounced effect on the mass-luminosity relation, i. e., the WR masses derived for a given luminosity may be considerably larger. Thereby, also the momentum problem of WR winds is considerably reduced, as well as the scatter in the ˙(M) vs. M diagram for observed hydrogen-free WN stars.

International Ultraviolet Explorer Observations of Wolf-Rayet Binaries: Wind Structures. Ph.D. Thesis

NASA Technical Reports Server (NTRS)

Koenigsberger, G.

1983-01-01

Spectra of six WN + OB Wolf-Rayet systems obtained with the IUE are analyzed for phase-dependent variations. Periodic variability at emission-line frequencies is detected in V444 Cyg, HD 90657, HD 211853, HD 186943 and HD 94546 on low dispersion SWP images. No changes in the low dispersion spectra of HD 193077 are apparent. We find the variations in the UV to be similar in nature to those observed in optical spectra of various WR sources. That is, there is a strengthening of absorption components in P Cygni-type features at orbital phases in which the O-star is behind the WR wind. With the aid of a computer code which models this type of variations, and through a comparison with HD 193077, the dominant mechanism producing the variations is shown to be selective atmospheric eclipses of the O-star by the WR wind. Based on this interpretation, a straightforward technique is applied to the line of N IV 1718, by which an optical depth distribution in the WN winds of the form tau varies as r(-1) is derived for 16 r 66 solar radii. Phase-dependent variations in the width of the C IV 1550 absorption component in V444 Cyg, HD 90657 and HD 211853 are interpretated as wind-wind collision effects.

Radioprotection of mouse skin vasculature and the RIF-1 fibrosarcoma by WR-2721

DOE Office of Scientific and Technical Information (OSTI.GOV)

Penhaligon, M.

1984-09-01

The degree of radioprotection obtained with WR-2721 is critically dependent upon the oxygen tension of the tissue concerned. It was therefore considered of interest to examine the response of vascular tissue, which would be supposedly well oxygenated, to treatment with WR-2721 plus X rays. The response of this tissue is of interest because of its role in late radiation damage. In addition, for therapeutic gain an agent must protect normal tissue without concomitant tumor protection. However, data on tumor radioprotection have been conflicting and therefore the effect of WR-2721 on an experimental tumor was also tested. Vascular damage was assessedmore » using the fact that tumors grow more slowly in irradiated beds (Tumor Bed Effect). WR-2721 injected 30 minutes before 5 to 30 Gy X rays protected skin stroma by a factor of 1.6. However, WR-2721 given 10 to 60 minutes before 20 Gy X rays to the RIF-1 tumor had either no effect or was protective, according to the method of immobilizing the mice during irradiation.« less

Eclipses and dust formation by WC9 type Wolf-Rayet stars

NASA Astrophysics Data System (ADS)

Williams, P. M.

2014-12-01

Visual photometry of 16 WC8-9 dust-making Wolf-Rayet (WR) stars during 2001-2009 was extracted from the All-Sky Automated Survey All Star Catalogue (ASAS-3) to search for eclipses attributable to extinction by dust formed in clumps in our line of sight. Data for a comparable number of dust-free WC6-9 stars were also examined to help characterize the data set. Frequent eclipses were observed from WR 104, and several from WR 106, extending the 1994-2001 studies by Kato et al., but not supporting their phasing the variations in WR 104 with its `pinwheel' rotation period. Only four other stars showed eclipses, WR 50 (one of the dust-free stars), WR 69, WR 95 and WR 117, and there may have been an eclipse by WR 121, which had shown two eclipses in the past. No dust eclipses were shown by the `historic' eclipsers WR 103 and WR 113. The atmospheric eclipses of the latter were observed but the suggestion by David-Uraz et al. that dust may be partly responsible for these is not supported. Despite its frequent eclipses, there is no evidence in the infrared images of WR 104 for dust made in its eclipses, demonstrating that any dust formed in this process is not a significant contributor to its circumstellar dust cloud and suggesting that the same applies to the other stars showing fewer eclipses.

A Modern Search for Wolf-Rayet Stars in the Magellanic Clouds. III. A Third Year of Discoveries

NASA Astrophysics Data System (ADS)

Massey, Philip; Neugent, Kathryn F.; Morrell, Nidia

2017-03-01

For the past three years we have been conducting a survey for Wolf-Rayet (WR) stars in the Large and Small Magellanic Clouds (LMC, SMC). Our previous work resulted in the discovery of a new type of WR star in the LMC, which we are calling WN3/O3. These stars have the emission-line properties of a WN3 star (strong N v, but no N IV), plus the absorption-line properties of an O3 star (Balmer hydrogen plus Pickering He II, but no He I). Yet, these stars are 15 times fainter than an O3 V star, ruling out the possibility that WN3/O3s are WN3+O3 binaries. Here we report the discovery of two more members of this class, bringing the total number of these objects to 10, 6.5% of the LMC’s total WR population. The optical spectra of nine of these WN3/O3s are virtually indistinguishable from each other, but one of the newly found stars is significantly different, showing a lower excitation emission and absorption spectrum (WN4/O4-ish). In addition, we have newly classified three unusual Of-type stars, including one with a strong C III λ 4650 line, and two rapidly rotating “Oef” stars. We also “rediscovered” a low mass X-ray binary, RX J0513.9-6951, and demonstrate its spectral variability. Finally, we discuss the spectra of 10 low priority WR candidates that turned out to not have He II emission. These include both a Be star and a B[e] star. This paper includes data gathered with the 1 m Swope and 6.5 m Magellan Telescopes located at Las Campanas Observatory, Chile.

K(2)MM'(3)Se(6) (M = Cu, Ag; M' = Ga, In), A new series of metal chalcogenides with chain-sublayer-chain slabs: (infinity)(1)[M'Se(4)]-(infinity)(2)[(MSe(4))(M'Se(4))]-(infinity)(1)[M'Se(4)].

PubMed

Ma, Hong-Wei; Guo, Guo-Cong; Wang, Ming-Sheng; Zhou, Guo-Wei; Lin, Shan-Hou; Dong, Zhen-Chao; Huang, Jin-Shun

2003-02-24

A new series of novel isostructural metal chalcogenides, K(2)CuIn(3)Se(6) (1), K(2)CuGa(3)Se(6) (2), and K(2)AgIn(3)Se(6) (3), were obtained by a reactive flux technique and structurally characterized. Compounds 1, 2, and 3 crystallize in the space group C2/c of the monoclinic system with eight formula units in a cell: a = 11.445(2) A, b = 11.495(2) A, c = 21.263(4) A, beta = 97.68(3) degrees, V = 2772(1) A(3), R1/wR2 = 0.0676/0.1652 for 1; a = 11.031(2) A, b = 11.050(4) A, c = 20.808(7) A, beta = 97.71(2) degrees, V = 2513(1) A(3), R1/wR2 = 0.0301/0.0511 for 2; and a = 11.633(1) A, b = 11.587(1) A, c = 21.355(1) A, beta = 98.010(8) degrees, V = 2850.4(4) A(3), R1/wR2 = 0.0471/0.0732 for 3. These isostructural compounds are characterized by a chain-sublayer-chain slab structure. The sublayer, composed of alternative corner-sharing mixed-metal tetrahedra, is sandwiched by parallel corner-sharing tetrahedral chains. Optical absorption spectra of compounds 1, 2, and 3 reveal the presence of a sharp optical gap of 1.68, 1.72, and 1.64 eV, respectively, suggesting that these materials are semiconductors and suitable for efficient absorption of solar radiation in solar cell applications. IR spectra show no obvious absorption in the range 800-4000 cm(-)(1).

Blood flow regulation and oxygen uptake during high-intensity forearm exercise.

PubMed

Nyberg, S K; Berg, O K; Helgerud, J; Wang, E

2017-04-01

The vascular strain is very high during heavy handgrip exercise, but the intensity and kinetics to reach peak blood flow, and peak oxygen uptake, are uncertain. We included 9 young (25 ± 2 yr) healthy males to evaluate blood flow and oxygen uptake responses during continuous dynamic handgrip exercise with increasing intensity. Blood flow was measured using Doppler-ultrasound, and venous blood was drawn from a deep forearm vein to determine arteriovenous oxygen difference (a-vO 2diff ) during 6-min bouts of 60, 80, and 100% of maximal work rate (WR max ), respectively. Blood flow and oxygen uptake increased ( P < 0.05) from 60%WR max [557 ± 177(SD) ml/min; 56.0 ± 21.6 ml/min] to 80%WR max (679 ± 190 ml/min; 70.6 ± 24.8 ml/min), but no change was seen from 80%WR max to 100%WR max Blood velocity (49.5 ± 11.5 to 58.1 ± 11.6 cm/s) and brachial diameter (0.49 ± 0.05 to 0.50 ± 0.06 cm) showed concomitant increases ( P < 0.05) with blood flow from 60% to 80%WR max, whereas no differences were observed in a-vO 2diff Shear rate also increased ( P < 0.05) from 60% (822 ± 196 s -1 ) to 80% (951 ± 234 s -1 ) of WR max The mean response time (MRT) was slower ( P < 0.05) for blood flow (60%WR max 50 ± 22 s; 80%WR max 51 ± 20 s; 100%WR max 51 ± 23 s) than a-vO 2diff (60%WR max 29 ± 9 s; 80%WR max 29 ± 5 s; 100%WR max 20 ± 5 s), but not different from oxygen uptake (60%WR max 44 ± 25 s; 80%WR max 43 ± 14 s; 100%WR max 41 ± 32 s). No differences were observed in MRT for blood flow or oxygen uptake with increased exercise intensity. In conclusion, when approaching maximal intensity, oxygen uptake appeared to reach a critical level at ~80% of WR max and be regulated by blood flow. This implies that high, but not maximal, exercise intensity may be an optimal stimulus for shear stress-induced small muscle mass training adaptations. NEW & NOTEWORTHY This study evaluated blood flow regulation and oxygen uptake during small muscle mass forearm exercise with high to maximal intensity. Despite utilizing only a fraction of cardiac output, blood flow reached a plateau at 80% of maximal work rate and regulated peak oxygen uptake. Furthermore, the results revealed that muscle contractions dictated bulk oxygen delivery and yielded three times higher peak blood flow in the relaxation phase compared with mean values. Copyright © 2017 the American Physiological Society.

Chemical modification of normal tissue damage induced by photodynamic therapy.

PubMed Central

Sigdestad, C. P.; Fingar, V. H.; Wieman, T. J.; Lindberg, R. D.

1996-01-01

One of the limitations of successful use of photodynamic therapy (PDT) employing porphyrins is the acute and long-term cutaneous photosensitivity. This paper describes results of experiments designed to test the effects of two radiation protective agents (WR-2721, 500 mg kg-1 or WR-3689, 700 mg kg-1) on murine skin damage induced by PDT. C3H mice were shaved and depilated three days prior to injection with the photosensitiser, Photofrin (5 or 10 mg kg-1). Twenty-four hours later, the mice were injected intraperitoneally with a protector 30 min prior to Argon dye laser (630 nm) exposure. The skin response was followed for two weeks post irradiation using an arbitrary response scale. A light dose response as well as a drug dose response was obtained. The results indicate that both protectors reduced the skin response to PDT, however WR-2721 was demonstrated to be the most effective. The effect of the protectors on vascular stasis after PDT was determined using a fluorescein dye exclusion assay. In mice treated with Photofrin (5 mg kg-1), and 630 nm light (180 J cm-2) pretreatment with either WR-2721 or WR-3689 resulted in significant protection of the vascular effects of PDT. These studies document the ability of the phosphorothioate class of radiation protective agents to reduce the effects of light on photosensitized skin. They do so in a drug dose-dependent fashion with maximum protection at the highest drug doses. PMID:8763855

Spectrophotometry of Wolf-Rayet stars. I - Continuum energy distributions

NASA Technical Reports Server (NTRS)

Morris, Patrick W.; Brownsberger, Kenneth R.; Conti, Peter S.; Massey, Philip; Vacca, William D.

1993-01-01

All available low-resolution IUE spectra are assembled for Galactic, LMC, and SMC W-R stars and are merged with ground-based optical and NIR spectra in order to collate in a systematic fashion the shapes of these energy distributions over the wavelength range 0.1-1 micron. They can be consistently fitted by a power law of the form F(lambda) is approximately equal to lambda exp -alpha over the range 1500-9000 A to derive color excesses E(B-V) and spectral indices by removing the 2175-A interstellar absorption feature. The WN star color excesses derived are found to be in good agreement with those of Schmutz and Vacca (1991) and Koesterke et al. (1991). Significant heterogeneity in spectral index values was generally seen with any given subtype, but the groups consisting of the combined set of Galactic and LMC W-R stars, the separate WN and WC sequences, and the Galactic and LMC W-R stars all showed a striking and consistent Gaussian-like frequency distribution of values.

Factors responsible for the patchy distribution of natural soil water repellency in Mediterranean semiarid forest

NASA Astrophysics Data System (ADS)

Lozano, E.; Jiménez-Pinilla, P.; Mataix-Solera, J.; González-Pérez, J. A.; García-Orenes, F.; Torres, M. P.; Arcenegui, V.; Mataix-Beneyto, J.

2012-04-01

Soil water repellency (WR) is commonly observed in forest areas showing wettable and water repellent patches with high spatial variability. This has important hydrological implications; in semiarid areas where water supply is limited, even slight WR may play an important role in infiltration patterns and distribution of water into the soil (Mataix-Solera et al., 2007). It has been proposed that the origin of WR is the release of organic compounds from different plants species and sources (due to waxes and other organic substances in their tissues; Doerr et al., 1998). However, the relationship between WR and plants may not always be a direct one: a group of fungi (mainly mycorrhizal fungi) and microorganisms could be also responsible for WR. The aim of this research is to study the relationships between WR in soils under different plant cover with selected soil properties and the quantity of fungi and their exudates. The study area is located in Southeast Spain, "Sierra de la Taja" near Pinoso (Alicante)), with a semiarid Mediterranean climate (Pm=260mm). Samples were taken in September 2011, when WR is normally strongest after summer drought. Soil samples were collected from the first 2.5cm of the mineral A horizon at microsites beneath each of the four most representative species (Pinus halepensis, Rosmarinus officinalis, Quercus. rotundifolia and Cistus albidus; n=15 per specie) and 5 samples from bare soil with no influence of any species. Different soil parameters were analyzed; water content, soil organic mater content (SOM), pH, WR, easily extractable glomalin (EEG), total mycelium and extractable lipids. The occurrence of WR was higher under P. halepensis (87% of samples) and Q. rotundifolia (60% of samples). Positive significant correlations were found between WR and SOM content for all species, with the best correlations for Pinus and Quercus (r=0.855**, r= 0.934** respectively). In addition, negative significant correlations were found between WR and pH and between SOM and pH for all except for Q. rotundifolia. However, the negative correlation found between pH and persistence of WR seems to be related to soil organic matter (SOM) content for all vegetal species. Glomalin exudates from arbuscular mycorrhizal fungi in soil revealed significant differences between species. However, the first results do not point to a direct relationship between EEG content and WR but to soil mineralogy or certain components within SOM pool i.e. litter debris degradation products or specific components within the glomalin extract, as main factors affecting soil WR. Nonetheless, since some samples with the same SOM content (including some under the same vegetation cover) showed different WR persistence, complementary research including a more detailed characterization of most soil functional fractions (SOM and clays) is planned in order to elucidat the main factors influencing the presence and persistence of WR in soils under Mediterranean semiarid forest. Keywords: Water repellency, hydrophobicity, easily extractable glomalin, mycelium, arbuscular mycorrhizal fungi.

Exposure to Leadership WalkRounds in neonatal intensive care units is associated with a better patient safety culture and less caregiver burnout

PubMed Central

Sexton, J Bryan; Sharek, Paul J; Thomas, Eric J; Gould, Jeffrey B; Nisbet, Courtney C; Amspoker, Amber B; Kowalkowski, Mark A; Schwendimann, René; Profit, Jochen

2014-01-01

Background Leadership WalkRounds (WR) are widely used in healthcare organisations to improve patient safety. The relationship between WR and caregiver assessments of patient safety culture, and healthcare worker burnout is unknown. Methods This cross-sectional survey study evaluated the association between receiving feedback about actions taken as a result of WR and healthcare worker assessments of patient safety culture and burnout across 44 neonatal intensive care units (NICUs) actively participating in a structured delivery room management quality improvement initiative. Results Of 3294 administered surveys, 2073 were returned for an overall response rate of 62.9%. More WR feedback was associated with better safety culture results and lower burnout rates in the NICUs. Participation in WR and receiving feedback about WR were less common in NICUs than in a benchmarking comparison of adult clinical areas. Conclusions WR are linked to patient safety and burnout. In NICUs, where they occurred more often, the workplace appears to be a better place to deliver and to receive care. PMID:24825895

Origin of the high velocity gas in NGC 6231

NASA Astrophysics Data System (ADS)

Massa, Derck

2017-08-01

It is well known that clusters of massive stars are influenced by the presence of strong winds, that they are sources of diffuse X-rays from shocked gas, and that this gas can be vented into the surrounding region or the halo, forming a critical element in the process of galactic feedback. However, the details of how these different environments interact and evolve are far from complete. Recently, Massa (2017) showed that the peculiar C IV 1550 Ang absorption seen in several otherwise normal main sequence B stars in NGC 6231 is not intrinsic to the stars. Instead, this absorption, which extends to more than -2000 km/s, is due to intervening carbon rich, high speed gas in the cluster environment. In this proposal, we seek to identify the origin of the high speed gas. The proposed observations will enable us to determine whether it is due to the outer wind of the WC star WR79, or to a collective cluster wind, enriched by carbon from the wind of WR79. If it is due to the wind of WR79, then the new data will furnish a novel, less model dependent estimate of the mass loss rate of a WC star. If it is due to a collective wind from the cluster, then we could be witnessing an important stage of galactic feedback. In either case, the proposed observations will provide a unique and significant insight on how massive, open clusters evolve - insight that can only be obtained through UV spectroscopy.

Adaptive responses of GLUT-4 and citrate synthase in fast-twitch muscle of voluntary running rats

NASA Technical Reports Server (NTRS)

Henriksen, E. J.; Halseth, A. E.

1995-01-01

Glucose transporter (GLUT-4) protein, hexokinase, and citrate synthase (proteins involved in oxidative energy production from blood glucose catabolism) increase in response to chronically elevated neuromuscular activity. It is currently unclear whether these proteins increase in a coordinated manner in response to this stimulus. Therefore, voluntary wheel running (WR) was used to chronically overload the fast-twitch rat plantaris muscle and the myocardium, and the early time courses of adaptative responses of GLUT-4 protein and the activities of hexokinase and citrate synthase were characterized and compared. Plantaris hexokinase activity increased 51% after just 1 wk of WR, whereas GLUT-4 and citrate synthase were increased by 51 and 40%, respectively, only after 2 wk of WR. All three variables remained comparably elevated (+50-64%) through 4 wk of WR. Despite the overload of the myocardium with this protocol, no substantial elevations in these variables were observed. These findings are consistent with a coordinated upregulation of GLUT-4 and citrate synthase in the fast-twitch plantaris, but not in the myocardium, in response to this increased neuromuscular activity. Regulation of hexokinase in fast-twitch muscle appears to be uncoupled from regulation of GLUT-4 and citrate synthase, as increases in the former are detectable well before increases in the latter.

Discovery of a new Wolf-Rayet star and a candidate star cluster in the Large Magellanic Cloud with Spitzer

NASA Astrophysics Data System (ADS)

Gvaramadze, V. V.; Chené, A.-N.; Kniazev, A. Y.; Schnurr, O.; Shenar, T.; Sander, A.; Hainich, R.; Langer, N.; Hamann, W.-R.; Chu, Y.-H.; Gruendl, R. A.

2014-08-01

We report the first-ever discovery of a Wolf-Rayet (WR) star in the Large Magellanic Cloud via detection of a circular shell with the Spitzer Space Telescope. Follow-up observations with Gemini-South resolved the central star of the shell into two components separated from each other by ≈2 arcsec (or ≈0.5 pc in projection). One of these components turns out to be a WN3 star with H and He lines both in emission and absorption (we named it BAT99 3a using the numbering system based on extending the Breysacher et al. catalogue). Spectroscopy of the second component showed that it is a B0 V star. Subsequent spectroscopic observations of BAT99 3a with the du Pont 2.5-m telescope and the Southern African Large Telescope revealed that it is a close, eccentric binary system, and that the absorption lines are associated with an O companion star. We analysed the spectrum of the binary system using the non-LTE Potsdam WR (POWR) code, confirming that the WR component is a very hot (≈90 kK) WN star. For this star, we derived a luminosity of log L/ L⊙ = 5.45 and a mass-loss rate of 10- 5.8 M⊙ yr- 1, and found that the stellar wind composition is dominated by helium with 20 per cent of hydrogen. Spectroscopy of the shell revealed an He III region centred on BAT99 3a and having the same angular radius (≈15 arcsec) as the shell. We thereby add a new example to a rare class of high-excitation nebulae photoionized by WR stars. Analysis of the nebular spectrum showed that the shell is composed of unprocessed material, implying that the shell was swept-up from the local interstellar medium. We discuss the physical relationship between the newly identified massive stars and their possible membership of a previously unrecognized star cluster.

Brown rice and retrograded brown rice alleviate inflammatory response in dextran sulfate sodium (DSS)-induced colitis mice.

PubMed

Praengam, Kemika; Sahasakul, Yuraporn; Kupradinun, Piengchai; Sakarin, Siriwan; Sanitchua, Wanwisa; Rungsipipat, Anudep; Rattanapinyopituk, Kasem; Angkasekwinai, Pornpimon; Changsri, Khaimuk; Mhuantong, Wuttichai; Tangphatsornruang, Sithichoke; Tuntipopipat, Siriporn

2017-12-13

The present study was aimed to investigate the impacts of brown rice (BR) and retrograded brown rice (R-BR) consumption on colonic health and gut microbiota in dextran sulfate sodium (DSS) induced colitis mice. Thirty two female C57Bl/6Mlac mice were fed with modified AIN 93G diets by replacing cornstarch in the original composition with white rice (WR), BR and R-BR powder. The mice were divided into 4 groups and fed with the following experimental diets for 4 weeks: (1) negative control (WR: diet with WR), (2) positive control (DSS_WR: DSS and diet with WR), (3) DSS_BR: DSS and diet with BR, and (4) DSS_R-BR: DSS and diet with R-BR. BR and R-BR had a greater content of fat, dietary fiber, GABA, γ-oryzanol, γ-tocotrienol, ferulic acid and p-coumaric acid than WR (p < 0.05). No significant difference in the level of these bioactive compounds was noted between BR and R-BR. Nevertheless, R-BR had a 1.8 fold resistant starch (RS) content of BR (p < 0.05). The DSS_BR and DSS_R-BR groups showed a lower ratio of colonic weight to length, and a lower content of iNOS, COX-2, MPO, IL-6 and INF-γ in colonic homogenates than the DSS_WR group. However, the DSS treated mice fed with the R-BR diet had significantly milder histopathological inflammatory injury and lower colonic iNOS expression than the DSS_BR and DSS_WR groups. The percentage of mesenteric regulatory T cells significantly increased in the DSS_R-BR group compared to that in the DSS_WR group. The DSS treated mice fed with the R-BR diet showed a significant increase in cecal bacterial diversity and abundance of genera Prevotella, Ruminococcus, Dorea, Coprococcus and Dehalobacterium but a significant decrease in pathogenic bacteria including Bacteroides and Enterococcus compared to the DSS_WR group. Thus, the present data indicate that BR and R-BR ameliorate colonic inflammation in experimental colitis induced by DSS in mice by suppressing inflammatory mediators and modulating regulatory T cell responses as well as bacterial diversity in the cecum.

X-ray Modeling of η Carinae & WR140 from SPH Simulations

NASA Astrophysics Data System (ADS)

Russell, Christopher M. P.; Corcoran, Michael F.; Okazaki, Atsuo T.; Madura, Thomas I.; Owocki, Stanley P.

2011-01-01

The colliding wind binary (CWB) systems η Carinae and WR140 provide unique laboratories for X-ray astrophysics. Their wind-wind collisions produce hard X-rays that have been monitored extensively by several X-ray telescopes, including RXTE. To interpret these RXTE X-ray light curves, we model the wind-wind collision using 3D smoothed particle hydrodynamics (SPH) simulations. Adiabatic simulations that account for the emission and absorption of X-rays from an assumed point source at the apex of the wind-collision shock cone by the distorted winds can closely match the observed 2-10keV RXTE light curves of both η Car and WR140. This point-source model can also explain the early recovery of η Car's X-ray light curve from the 2009.0 minimum by a factor of 2-4 reduction in the mass loss rate of η Car. Our more recent models relax the point-source approximation and account for the spatially extended emission along the wind-wind interaction shock front. For WR140, the computed X-ray light curve again matches the RXTE observations quite well. But for η Car, a hot, post-periastron bubble leads to an emission level that does not match the extended X-ray minimum observed by RXTE. Initial results from incorporating radiative cooling and radiatively-driven wind acceleration via a new anti-gravity approach into the SPH code are also discussed.

[Biomechanical characteristics of the wiping reflex cycle].

PubMed

Berkinblit, M B; Zharkova, I S; Fel'dman, A G; Fukson, O I

1984-01-01

Multijoint goal-directed hindlimb movements in response to chemical stimulation delivered to different skin sites on the medial back surface (wiping reflex-WR) were filmed and analysed in spinal or intact frogs Rana temporaria. Each WR cycle was divisible into five phases (flexion, lifting, aiming, wiping and extension) usually separated from each other by postural interruptions. One or several of the phases might spontaneously be reduced or deleted at all (e. g. the extension phase), although the WR was still effective. Such a reduction was, as a rule, observed in intact frogs while spinal ones usually exhibited the maximum phase sequence. It is suggested that the central spinal generator of the WR is formed of separate functional blocks each of which specifies a certain interjoint coordination and brings the joints to the central-conditioned equilibrium positions.

Assessment of antiradiation drug effectiveness to fission neutron irradiation. Annual report September 1981-August 1982

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sigdestad, C.P.

1982-09-01

This report describes the assays of various compounds for their toxicity and anti-radiation efficacy following exposure to either Co-60 or fission neutron irradiation. The chemicals covered in this report are: WR 347, WR 1065, WR 2529, WR 2721, WR 3689, WR 44923, WR 109342, WR 151327 and WR 168643. The drugs and their respective dose modification factors (DMF) for fission neutron gastrointestinal lethality (LD50-6) following intraperitoneal administration are, in decreasing order of effectiveness: WR 44923 (1.77), WR 2529 (1.47), WR 1065 (1.42), WR 2721 (1.39), WR 16843 (1.23). Following per os (P. O.) administration of the drug, the DMF's formore » the LD50-6 are: WR 109342 (1.47), WR 3689 (1.36), and WR 168643 (1.31). For hematopoietic neutron radiation lethality (LD50-30) the DMF's are: following i.p. administration, WR 2529 (1.04); WR 151327 (1.34), WR 168643 (1.25), WR 44923 (1.22), WR 2721 (1.20), WR 1065 (1.04); following P. O. administration, WR 168643 (1.38), WR 109342 (1.21), WR 3689 (1.04). Using an intestinal microcolony assay system the following drugs provided the listed DMF's against neutron radiation after i.p. injection: WR 3689 (1.24), WR 2721 (1.15), WR 44923 (1.14), and WR 347 (1.05). The protective effects against neutron radiation using an endogenous spleen colony assay and i.p. administration were: WR 3689 (1.18), WR 2529 (1.15), WR 2721 (1.10), WR 44923 (1.02) and WR 347 (0.94).« less

Analysis of Investigational Drugs in Biological Fluids. Method Development and Routine Assay. Appendix A.

DTIC Science & Technology

1997-02-13

AMINOPROPIOPHENONE IN DOG PLASMA 0 OCH 3 CH2 CH3 OCH2CHOHCH 2 OH H2 N& p-Aminopropiophenone Guaifenesin (WR 000,302) Internal Standard APPROVALS: This Analytical...40 - 80 il VOLUME: RUN TIME: 14 min (PAPP: 10.7 min; Guaifenesin (Internal Standard): 8.5 min) DETECTOR Wavelength: 316 nm SETTINGS: Absorption Range

Insoluble fiber is a major constituent responsible for lowering the post-prandial blood glucose concentration in the pre-germinated brown rice.

PubMed

Seki, Taiichiro; Nagase, Ryohei; Torimitsu, Mariko; Yanagi, Megumi; Ito, Yukihiko; Kise, Mitsuo; Mizukuchi, Aya; Fujimura, Naoko; Hayamizu, Kohusuke; Ariga, Toyohiko

2005-08-01

The intake of pre-germinated brown rice (PR) instead of white rice (WR) ameliorates the hyperglycemia. To clarify the mechanism(s) to decrease the post-prandial blood glucose concentration, the effect of water-soluble/oil-soluble fraction-depleted PR bran (termed as "DB"; which is destarched and defatted PR bran) on post-prandial blood glucose was compared with that of full-fat PR bran (PB) or WR. The test diets, WR diet, PB diet and DB diet which are containing identical amount of available carbohydrate (1.5 g) were fed to Wistar strain rats. Post-prandial blood glucose concentration and incremental area under the curve (IAUC) for DB diet were lower than those for WR diet, and there was no difference between the DB diet and PB diet. Changes in plasma insulin concentration and the IAUC obtained also revealed the same tendency as those observed in blood glucose concentration. These results indicate that the blood glucose-lowering effect of PB diet may be derived from the properties of PB involving substantially higher content of dietary fiber than WR, and that the potential benefit of intake of PR instead of WR in the prevention of diabetic vascular complications.

X-Ray Emission from Massive Stars in Cyg OB2

NASA Astrophysics Data System (ADS)

Rauw, G.; Nazé, Y.; Wright, N. J.; Drake, J. J.; Guarcello, M. G.; Prinja, R. K.; Peck, L. W.; Albacete Colombo, J. F.; Herrero, A.; Kobulnicky, H. A.; Sciortino, S.; Vink, J. S.

2015-11-01

We report on the analysis of the Chandra-ACIS data of O, B, and WR stars in the young association Cyg OB2. X-ray spectra of 49 O-stars, 54 B-stars, and 3 WR-stars are analyzed and for the brighter sources, the epoch dependence of the X-ray fluxes is investigated. The O-stars in Cyg OB2 follow a well-defined scaling relation between their X-ray and bolometric luminosities: {log}\\\\frac{{L}{{X}}}{{L}{bol}}=-7.2+/- 0.2. This relation is in excellent agreement with the one previously derived for the Carina OB1 association. Except for the brightest O-star binaries, there is no general X-ray overluminosity due to colliding winds in O-star binaries. Roughly half of the known B-stars in the surveyed field are detected, but they fail to display a clear relationship between LX and Lbol. Out of the three WR stars in Cyg OB2, probably only WR 144 is itself responsible for the observed level of X-ray emission, at a very low {log}\\\\frac{{L}{{X}}}{{L}{bol}}=-8.8+/- 0.2. The X-ray emission of the other two WR-stars (WR 145 and 146) is most probably due to their O-type companion along with a moderate contribution from a wind-wind interaction zone.

Assessment of antiradiation drug effectiveness to fission neutron irradiation. Annual report No. 1, April-August 1981

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sigdestad, C.P.

1981-09-01

This report deals with the assays of various compounds for their toxicity of anti-radiation efficacy following exposure to either Co-60 or fission neutron irradiation. The compounds reported herein include WR 347, WR 2721, WR 3689, WR 44923, WR 109342, WR 151327, WR 16843, and WR 176542. The end-points measured in the radiation studies were LD50(6) and LD50(30). The compounds and their dose modification factors (DMF) for the neutron LD50(6) following i.p. administration, were, in descending order of effectiveness: WR 151327 (1.42), WR 347 (1.37), WR 3689 (1.34) WR 44923 (1.34), WR 2721 (1.26), WR 168643 (1.24), and WR 176542 (1.23).more » The corresponding LD50(30)'s for fission neutron irradiation following i.p. administration, were: WR 168643 (1.67), WR 3689 (1.52), WR 151327 (1.45), WR 44923 (1.39), WR 347 (1.22), WR 2721 (1.21), and WR 176542 (1.18). For low LET Co-60 gamma irradiation the LD50(6) and LD50(30) were determined for WR 347 following i.p. administration. The DMF's obtained were: LD50(6) (1.4), LD50(30) (1.5).« less

Influence of cycling history on the ventilatory response to cycle-ergometry in humans: a role for respiratory memory?

PubMed

Cathcart, Andrew J; Whipp, Brian J; Turner, Anthony P; Wilson, John; Ward, Susan A

2010-01-01

The ventilatory (V' E) mechanisms subserving stability of alveolar and arterial PCO2 (PACO2, PaCO2) during moderate exercise (< lactate threshold, thetaL) remain controversial. As long-term modulation has been argued to be an important contributor to this control process, we proposed that subjects with no experience of cycling (NEx) might provide insight into this issue. With no exercise familiarization, 9 sedentary NEx subjects and 9 age-, sex-, and activity-matched controls (C) who had cycled regularly for recreational purposes since childhood completed a square-wave (6-min stage) cycle-ergometry test: 10 W-WR1-WR2-WR1-10 W; WR1 range 25-45 W, WR2 range 50-90 W. WRs were subsequently confirmed to

Comparative study of some robust statistical methods: weighted, parametric, and nonparametric linear regression of HPLC convoluted peak responses using internal standard method in drug bioavailability studies.

PubMed

Korany, Mohamed A; Maher, Hadir M; Galal, Shereen M; Ragab, Marwa A A

2013-05-01

This manuscript discusses the application and the comparison between three statistical regression methods for handling data: parametric, nonparametric, and weighted regression (WR). These data were obtained from different chemometric methods applied to the high-performance liquid chromatography response data using the internal standard method. This was performed on a model drug Acyclovir which was analyzed in human plasma with the use of ganciclovir as internal standard. In vivo study was also performed. Derivative treatment of chromatographic response ratio data was followed by convolution of the resulting derivative curves using 8-points sin x i polynomials (discrete Fourier functions). This work studies and also compares the application of WR method and Theil's method, a nonparametric regression (NPR) method with the least squares parametric regression (LSPR) method, which is considered the de facto standard method used for regression. When the assumption of homoscedasticity is not met for analytical data, a simple and effective way to counteract the great influence of the high concentrations on the fitted regression line is to use WR method. WR was found to be superior to the method of LSPR as the former assumes that the y-direction error in the calibration curve will increase as x increases. Theil's NPR method was also found to be superior to the method of LSPR as the former assumes that errors could occur in both x- and y-directions and that might not be normally distributed. Most of the results showed a significant improvement in the precision and accuracy on applying WR and NPR methods relative to LSPR.

Drug Evaluation in the Plasmodium Falciparum-Aotus Model

DTIC Science & Technology

1996-03-01

infections. Although erythromycin is inactive against chloroquine -resistant falciparum infections, an analogue , azithromycin, is effective in vitro...s, infection parameters characterized, confirm their response to chloroquine , and then expand the evaluation of WR 238605, a primaquine analogue ... chloroquine resistance was confirmed, as was the activity of WR 238605 (a primaquine analogue ), 1.0 mglkg (x 3 days) cleared parasitemias but with

Efficient delivery of cell impermeable phosphopeptides by a cyclic peptide amphiphile containing tryptophan and arginine.

PubMed

Nasrolahi Shirazi, Amir; Tiwari, Rakesh Kumar; Oh, Donghoon; Banerjee, Antara; Yadav, Arpita; Parang, Keykavous

2013-05-06

Phosphopeptides are valuable reagent probes for studying protein-protein and protein-ligand interactions. The cellular delivery of phosphopeptides is challenging because of the presence of the negatively charged phosphate group. The cellular uptake of a number of fluorescent-labeled phosphopeptides, including F'-GpYLPQTV, F'-NEpYTARQ, F'-AEEEIYGEFEAKKKK, F'-PEpYLGLD, F'-pYVNVQN-NH2, and F'-GpYEEI (F' = fluorescein), was evaluated in the presence or absence of a [WR]4, a cyclic peptide containing alternative arginine (R) and tryptophan (W) residues, in human leukemia cells (CCRF-CEM) after 2 h incubation using flow cytometry. [WR]4 improved significantly the cellular uptake of all phosphopeptides. PEpYLGLD is a sequence that mimics the pTyr1246 of ErbB2 that is responsible for binding to the Chk SH2 domain. The cellular uptake of F'-PEpYLGLD was enhanced dramatically by 27-fold in the presence of [WR]4 and was found to be time-dependent. Confocal microscopy of a mixture of F'-PEpYLGLD and [WR]4 in live cells exhibited intracellular localization and significantly higher cellular uptake compared to that of F'-PEpYLGLD alone. Transmission electron microscopy (TEM) and isothermal calorimetry (ITC) were used to study the interaction of PEpYLGLD and [WR]4. TEM results showed that the mixture of PEpYLGLD and [WR]4 formed noncircular nanosized structures with width and height of 125 and 60 nm, respectively. ITC binding studies confirmed the interaction between [WR]4 and PEpYLGLD. The binding isotherm curves, derived from sequential binding models, showed an exothermic interaction driven by entropy. These studies suggest that amphiphilic peptide [WR]4 can be used as a cellular delivery tool of cell-impermeable negatively charged phosphopeptides.

The extent to which the public health 'war on obesity' reflects the ethical values and principles of critical health promotion: a multimedia critical discourse analysis.

PubMed

O'Hara, Lily; Taylor, Jane; Barnes, Margaret

2015-12-01

The discipline of health promotion is responsible for implementing strategies within weight-related public health initiatives (WR-PHI). It is imperative that such initiatives be subjected to critical analysis through a health promotion ethics lens to help ensure ethical health promotion practice. Multimedia critical discourse analysis was used to examine the claims, values, assumptions, power relationships and ideologies within Australian WR-PHI. The Health Promotion Values and Principles Continuum was used as a heuristic to evaluate the extent to which the WR-PHI reflected the ethical values of critical health promotion: active participation of people in the initiative; respect for personal autonomy; beneficence; non-maleficence; and strong evidential and theoretical basis for practice. Ten initiatives were analysed. There was some discourse about the need for participation of people in the WR-PHI, but people were routinely labelled as 'target groups' requiring 'intervention'. Strong evidence of a coercive and paternalistic discourse about choice was identified, with minimal attention to respect for personal autonomy. There was significant emphasis on the beneficiaries of the WR-PHI but minimal attention to the health benefits, and nothing about the potential for harm. Discourse about the evidence of need was objectivist, and there was no discussion about the theoretical foundations of the WR-PHI. The WR-PHI were not reflective of the ethical values and principles of critical health promotion. So what? Health promotion researchers and practitioners engaged in WR-PHI should critically reflect on the extent to which they are consistent with the ethical aspects of critical health promotion practice.

Antipsychotic profile of cannabidiol and rimonabant in an animal model of emotional context processing in schizophrenia.

PubMed

Levin, Raquel; Almeida, Valeria; Peres, Fernanda Fiel; Calzavara, Mariana Bendlin; da Silva, Neide Derci; Suiama, Mayra Akimi; Niigaki, Suzy Tamie; Zuardi, Antonio Waldo; Hallak, Jaime Eduardo Cecilio; Crippa, Jose Alexandre; Abílio, Vanessa Costhek

2012-01-01

Clinical and neurobiological findings suggest that cannabinoids and their receptors are implicated in schizophrenia. Cannabidiol (CBD), a non-psychotomimetic compound of the Cannabis sativa plant, has been reported to have central therapeutic actions, such as antipsychotic and anxiolytic effects. We have recently reported that spontaneously hypertensive rats (SHR) present a deficit in contextual fear conditioning (CFC) that is specifically ameliorated by antipsychotics and aggravated by proschizophrenia manipulations. These results led us to suggest that the CFC deficit presented by SHR could be used as a model to study emotional processing impairment in schizophrenia. The aim of this study is to evaluate the effects of CBD and rimonabant (CB1 receptor antagonist) on the contextual fear conditioning in SHR and Wistar rats (WR). Rats were submitted to CFC task after treatment with different doses of CBD (experiment 1) and rimonabant (experiment 2). In experiment 1, SHR showed a decreased freezing response when compared to WR that was attenuated by 1 mg/kg CBD. Moreover, all CBD-treated WR presented a decreased freezing response when compared to control rats. In experiment 2, SHR showed a decreased freezing response when compared to WR that was attenuated by 3 mg/kg rimonabant. Our results suggest a potential therapeutical effect of CBD and rimonabant to treat the emotional processing impairment presented in schizophrenia. In addition, our results reinforce the anxiolytic profile of CBD.

Do the Threshold Limit Values for Work in Hot Conditions Adequately Protect Workers?

PubMed

Meade, Robert D; Poirier, Martin P; Flouris, Andreas D; Hardcastle, Stephen G; Kenny, Glen P

2016-06-01

We evaluated core temperature responses and the change in body heat content (ΔHb) during work performed according to the ACGIH threshold limit values (TLV) for heat stress, which are designed to ensure a stable core temperature that does not exceed 38.0°C. Nine young males performed a 120-min work protocol consisting of cycling at a fixed rate of heat production (360 W). On the basis of the TLV, each protocol consisted of a different work-rest (WR) allocation performed in different wet-bulb globe temperatures (WBGT). The first was 120 min of continuous (CON) cycling at 28.0°C WBGT (CON[28.0°C]). The remaining three protocols were intermittent work bouts (15-min duration) performed at various WR and WBGT: (i) WR of 3:1 at 29.0°C (WR3:1[29.0°C]), (ii) WR of 1:1 at 30.0°C (WR1:1[30.0°C]), and (iii) WR of 1:3 at 31.5°C (WR1:3[31.5°C]) (total exercise time: 90, 60, and 30 min, respectively). The change in rectal (ΔTre) and mean body temperature (ΔTb) was evaluated with thermometry. ΔHb was determined via direct calorimetry and also used to calculate ΔTb. Although average rectal temperature did not exceed 38.0°C, heat balance was not achieved during exercise in any work protocol (i.e., rate of ΔTre > 0°C·min; all P values ≤ 0.02). Consequently, it was projected that if work was extended to 4 h, the distribution of participant core temperatures higher and lower than 38.0°C would be statistically similar (all P values ≥ 0.10). Furthermore, ΔHb was similar between protocols (P = 0.70). However, a greater ΔTb was observed with calorimetry relative to thermometry in WR3:1[29.0°C] (P = 0.03), WR1:1[30.0°C] (P = 0.02), and WR1:3[31.5°C] (P < 0.01) but not CON[28.0°C] (P = 0.32). The current study demonstrated that heat balance was not achieved and ΔTb and ΔHb were inconsistent, suggesting that the TLV may not adequately protect workers during work in hot conditions.

Antihyperlipidemic activity of Ichnocarpus frutescens in triton WR-1339-induced and high-fat diet animals.

PubMed

Saravanan, M; Pandikumar, P; Prakash Babu, N; Ignacimuthu, S

2011-10-01

Ichnocarpus frutescens (L.) R.Br. (Apocynaceae) is used to treat diabetes and hyperlipidemia in folk medicine. The crude methanol extract and fractions of I. frutescens were investigated for antihyperlipidemic effect. Fresh leaves of I. frutescens were extracted with methanol and fractionated with hexane, benzene, ethyl acetate, acetone, and methanol. The active acetone fraction was subfractionated, which resulted in active fraction 3. The antihyperlipidemic effects of the methanol extract and fractions of I. frutescens were studied in triton WR-1339-induced and high-fat diet (HFD) obese animals. Further, lipid absorption and excretion were studied. The methanol extract significantly reduced total cholesterol (TC) by 29.63% and triglyceride (Tg) by 51.10% at 400 mg/kg in triton WR-1339-induced animals and significantly reduced TC (27.81%) and Tg (37.03%) at 400 mg/kg in HFD animals. Fraction 3 showed significant reduction in TC (25.03%) and Tg (58.05%) at 200 mg/kg. Feeding of HFD consisting 3% of fraction 3 increased feces weight and Tg level in mice. Fraction 3, showed significant decrease in plasma Tg level at the second hour, after oral administration of the lipid emulsion to rats. The observed properties apparently validate the folk medicinal use of this plant in amelioration of hyperlipidemia.

Decoding of the light changes in eclipsing Wolf-Rayet binaries. I. A non-classical approach to the solution of light curves

NASA Astrophysics Data System (ADS)

Perrier, C.; Breysacher, J.; Rauw, G.

2009-09-01

Aims: We present a technique to determine the orbital and physical parameters of eclipsing eccentric Wolf-Rayet + O-star binaries, where one eclipse is produced by the absorption of the O-star light by the stellar wind of the W-R star. Methods: Our method is based on the use of the empirical moments of the light curve that are integral transforms evaluated from the observed light curves. The optical depth along the line of sight and the limb darkening of the W-R star are modelled by simple mathematical functions, and we derive analytical expressions for the moments of the light curve as a function of the orbital parameters and the key parameters of the transparency and limb-darkening functions. These analytical expressions are then inverted in order to derive the values of the orbital inclination, the stellar radii, the fractional luminosities, and the parameters of the wind transparency and limb-darkening laws. Results: The method is applied to the SMC W-R eclipsing binary HD 5980, a remarkable object that underwent an LBV-like event in August 1994. The analysis refers to the pre-outburst observational data. A synthetic light curve based on the elements derived for the system allows a quality assessment of the results obtained.

ORACLE (Oversight of Resources and Capability for Logistics Effectiveness) and Requirements Forecasting. Volume 3. Predicting the Peacetime Spares Requirements.

DTIC Science & Technology

1988-05-01

Shearing Machines WR/MMI DG 3446 Forging Machinery and Hammers WR/MMI DG 3447 Wire and Metal Ribbon Forming Machines WR/MMI DG 3448 Riveting Machines ...R/MN1I DG 3449 Miscellaneous Secondary Metal Forming & Cutting WR/MMI DG Machinery 3450 Machine Tools, Portable WR/MMI DG 3455 Cutting Tools for...Secondary Metalworking Machinery WR/MMI DG WR 3465 Production Jigs, Fixtures and Templates WR/MMI DG WR 3470 Machine Shop Sets, Kits, and Outfits WR/MMI DG

Effects of chronic weight perturbation on energy homeostasis and brain structure in mice

PubMed Central

Ravussin, Y.; Gutman, R.; Diano, S.; Shanabrough, M.; Borok, E.; Sarman, B.; Lehmann, A.; LeDuc, C. A.; Rosenbaum, M.; Horvath, T. L.

2011-01-01

Maintenance of reduced body weight in lean and obese human subjects results in the persistent decrease in energy expenditure below what can be accounted for by changes in body mass and composition. Genetic and developmental factors may determine a central nervous system (CNS)-mediated minimum threshold of somatic energy stores below which behavioral and metabolic compensations for weight loss are invoked. A critical question is whether this threshold can be altered by environmental influences and by what mechanisms such alterations might be achieved. We examined the bioenergetic, behavioral, and CNS structural responses to weight reduction of diet-induced obese (DIO) and never-obese (CON) C57BL/6J male mice. We found that weight-reduced (WR) DIO-WR and CON-WR animals showed reductions in energy expenditure, adjusted for body mass and composition, comparable (−10–15%) to those seen in human subjects. The proportion of excitatory synapses on arcuate nucleus proopiomelanocortin neurons was decreased by ∼50% in both DIO-WR and CON-WR mice. These data suggest that prolonged maintenance of an elevated body weight (fat) alters energy homeostatic systems to defend a higher level of body fat. The synaptic changes could provide a neural substrate for the disproportionate decline in energy expenditure in weight-reduced individuals. This response to chronic weight elevation may also occur in humans. The mouse model described here could help to identify the molecular/cellular mechanisms underlying both the defense mechanisms against sustained weight loss and the upward resetting of those mechanisms following sustained weight gain. PMID:21411766

EMG and oxygen uptake responses during slow and fast ramp exercise in humans.

PubMed

Scheuermann, Barry W; Tripse McConnell, Joyce H; Barstow, Thomas J

2002-01-01

This study examined the relationship between muscle recruitment patterns using surface electromyography (EMG) and the excess O(2) uptake (Ex.V(O(2))) that accompanies slow (SR, 8 W min(-1)) but not fast (FR, 64 W min(-1)) ramp increases in work rate (WR) during exercise on a cycle ergometer. Nine subjects (2 females) participated in this study (25 +/- 2 years, +/- S.E.M.). EMG was obtained from the vastus lateralis and medialis and analysed in the time (root mean square, RMS) and frequency (median power frequency, MDPF) domain. Results for each muscle were averaged to provide an overall response and expressed relative to a maximal voluntary contraction (%MVC). Delta.V(O(2))/DeltaWR was calculated for exercise below (S(1)) and above (S(2)) the lactate threshold (LT) using linear regression. The increase in RMS relative to the increase in WR for exercise below the LT (DeltaRMS/DeltaWR-S(1)) was determined using linear regression. Due to non-linearities in RMS above the LT, DeltaRMS/DeltaWR-S(2) is reported as the difference in RMS (DeltaRMS) and the difference in WR (DeltaWR) at end-exercise and the LT. SR was associated with a higher (P < 0.05) Delta.V(O(2))/DeltaWR (S(1), 9.3 +/- 0.3 ml min(-1) W(-1); S(2), 12.5 +/- 0.6 ml min(-1) W(-1)) than FR (S(1), 8.5 +/- 0.4 ml min(-1) W(-1); S(2), 7.9 +/- 0.4 ml min(-1) W(-1)) but a similar DeltaRMS/DeltaWR-S(1) (SR, 0.11 +/- 0.01% W(-1); FR, 0.10 +/- 0.01 % W(-1)). Ex.V(O(2)) was greater (P < 0.05) in SR (3.6 +/- 0.7 l) than FR (-0.7 +/- 0.4 l) but was not associated with a difference in either DeltaRMS/DeltaWR-S(2) (SR, 0.14 +/- 0.01% W(-1); FR, 15 +/- 0.02 % W(-1)) or MDPF (SR, 2.6 +/- 5.9 %; FR, -15.4 +/- 4.5 %). The close matching between power output and RMS during SR and FR suggests that the Ex.V(O(2)) of heavy exercise is not associated with the recruitment of additional motor units since Ex.V(O(2)) was observed during SR only. Compared to the progressive decrease in MDPF observed during FR, the MDPF remained relatively constant during SR suggesting that either (i) there was no appreciable recruitment of the less efficient type II muscle fibres, at least in addition to those recruited initially at the onset of exercise, or (ii) the decrease in MDPF associated with fatigue was offset by the addition of a higher frequency of type II fibres recruited to replace the fatigued motor units.

Cardiorespiratory demand of acute voluntary cycling with functional electrical stimulation in individuals with multiple sclerosis with severe mobility impairment.

PubMed

Edwards, Thomas; Motl, Robert W; Pilutti, Lara A

2018-01-01

Exercise training is one strategy for improving cardiorespiratory fitness (CRF) in multiple sclerosis (MS); however, few modalities are accessible for those with severe mobility impairment. Functional electrical stimulation (FES) cycling is an adapted exercise modality with the potential for improving CRF in people with severe MS. The objective of this study was to characterize the cardiorespiratory response of acute voluntary cycling with FES in people with MS with severe mobility impairment, and to compare this response to passive leg cycling. Eleven participants with MS that required assistance for ambulation completed a single bout of voluntary cycling with FES or passive leg cycling. Oxygen consumption, heart rate (HR), work rate (WR), and ratings of perceived exertion (RPE) were recorded throughout the session. For the FES group, mean exercising oxygen consumption was 8.7 ± 1.8 mL/(kg·min) -1 , or 63.5% of peak oxygen consumption. Mean HR was 102 ± 9.7 bpm, approximately 76.4% of peak HR. Mean WR was 27.0 ± 9.2 W, or 57.3% of peak WR, and median RPE was 13.5 (interquartile range = 5.5). Active cycling with FES was significantly (p < 0.05) more intense than passive leg cycling based on oxygen consumption, HR, WR, and RPE during exercise. In conclusion, voluntary cycling with FES elicited an acute response that corresponded with moderate-to vigorous-intensity activity, suggesting that active cycling with FES can elicit a sufficient stimulus for improving CRF.

O2 uptake kinetics during exercise at peak O2 uptake.

PubMed

Scheuermann, Barry W; Barstow, Thomas J

2003-11-01

Compared with moderate- and heavy-intensity exercise, the adjustment of O2 uptake (VO2) to exercise intensities that elicit peak VO2 has received relatively little attention. This study examined the VO2 response of 21 young, healthy subjects (25 +/- 6 yr; mean +/- SD) during cycle ergometer exercise to step transitions in work rate (WR) corresponding to 90, 100, and 110% of the peak WR achieved during a preliminary ramp protocol (15-30 W/min). Gas exchange was measured breath by breath and interpolated to 1-s values. VO2 kinetics were determined by use of a two- or three-component exponential model to isolate the time constant (tau2) as representative of VO2 kinetics and the amplitude (Amp) of the primary fast component independent of the appearance of any VO2 slow component. No difference in VO2 kinetics was observed between WRs (tau90 = 24.7 +/- 9.0; tau100 = 22.8 +/- 6.7; tau110 = 21.5 +/- 9.2 s, where subscripts denote percent of peak WR; P > 0.05); nor in a subgroup of eight subjects was tau2 different from the value for moderate-intensity ( 0.05). As expected, the Amp increased with increasing WRs (Amp90 = 2,089 +/- 548; Amp100 = 2,165 +/- 517; Amp110 = 2,225 +/- 559 ml/min; Amp90 vs. Amp110, P < 0.05). However, the gain (G) of the VO2 response (deltaVO2/deltaWR) decreased with increasing WRs (G90 = 8.5 +/- 0.6; G100 = 7.9 +/- 0.6; G110 = 7.3 +/- 0.6 ml.min-1.W-1; P < 0.05). The Amp of the primary component approximated 85, 88, and 89% of peak Vo2 during 90, 100, and 110% WR transitions, respectively. The results of the present study demonstrate that, compared with moderate- and heavy-intensity exercise, the gain of the Vo2 response (as deltaVO2/DeltaWR) is reduced for exercise transitions in the severe-intensity domain, but the approach to this gain is well described by a common time constant that is invariant across work intensities. The lower deltaVO2/deltaWR may be due to an insufficient adjustment of the cardiovascular and/or pulmonary systems that determine O2 delivery to the exercising muscles or due to recruitment of motor units with lower oxidative capacity, after the onset of exercise in the severe-intensity domain.

Exploring functional relationships between post-fire soil water repellency, soil structure and physico-chemical properties

NASA Astrophysics Data System (ADS)

Quarfeld, Jamie; Brook, Anna; Keestra, Saskia; Wittenberg, Lea

2016-04-01

Soil water repellency (WR) and aggregate stability (AS) are two soil properties that are typically modified after burning and impose significant influence on subsequent hydrological and geomorphological dynamics. The response of AS and soil WR to fire depends upon how fire has influenced other key soil properties (e.g. soil OM, mineralogy). Meanwhile, routine thinning of trees and woody vegetation may alter soil properties (e.g. structure and porosity, wettability) by use of heavy machinery and species selection. The study area is situated along a north-facing slope of Mount Carmel national park (Israel). The selected sites are presented as a continuum of management intensity and fire histories. To date, the natural baseline of soil WR has yet to be thoroughly assessed and must be investigated alongside associated soil aggregating parameters in order to understand its overall impact. This study examines (i) the natural baseline of soil WR and physical properties compared to those of disturbed sites in the immediate (controlled burn) and long-term (10-years), and (ii) the interactions of soil properties with different control factors (management, surface cover, seasonal-temporal, burn temperature, soil organic carbon (OC) and mineralogy) in Mediterranean calcareous soils. Analysis of surface soil samples before and after destruction of WR by heating (200-600°C) was implemented using a combination of traditional methods and infrared (IR) spectroscopy. Management and surface cover type conditioned the wettability, soil structure and porosity of soils in the field, although this largely did not affect the heat-induced changes observed in the lab. A positive correlation was observed along an increasing temperature gradient, with relative maxima of MWD and BD reached by most soils at the threshold of 400-500°C. Preliminary analyses of soil OC (MIR) and mineralogical composition (VIS-NIR) support existing research regarding: (i) the importance of soil OC quality and composition in determining wettability rather than quantity, as evidenced both by the high variation observed in the field and the strong presence of aliphatic functional groups in the absence of WR; and (ii) commonly proposed mechanisms affecting soil aggregate properties - albeit with differing temperature thresholds and longer exposure times employed in this study. Namely, these mechanisms tend to involve: (i) soil OM and WR reduction at low to moderate temperatures, and (ii) thermal fusion of particles within moderate to high temperatures. Overall, results suggest a positive influence of management on soil properties as well as high soil resilience to moderate severity fire disturbance in the studied areas. However, the specific changes in soil OM and mineral composition that are responsible for destruction of WR and subsequent changes in AS remain poorly understood. Based on these results, a key next step within this study will entail a closer examination of OC ratios and their potential links with certain mineral species known to influence soil aggregation and soil WR. Noting the importance of soil OM-mineralogical interactions on run-off and erosion processes, results may contribute to better prediction of post-fire responses in the future and improve the ability to fine-tune site specific management approaches accordingly.

Medium-term evolution of water repellency and aggregate stability in Mediterranean calcareous soils after wildfire

NASA Astrophysics Data System (ADS)

Gordillo-Rivero, Ángel; García-Moreno, Jorge; Zavala, Lorena M.; Jordán, Antonio; Granged, Arturo JP; Gil, Juan

2013-04-01

Wildfires are a common feature of Mediterranean ecosystems due to environmental factors and anthropic influence, especially in those areas where land use change and the development of touristic infrastructures are more intense. Wildfires induce a series of soil changes affecting their physical and chemical properties and the hydrological and erosive response. Two of the properties that are commonly affected by burning are soil water repellency (WR) and aggregate stability (AS). Both properties play an important role in the hydrological response of soils and other processes, and may be used as indices for assessing burn severity (Gordillo-Rivero et al., 2013). OBJECTIVES The field study was carried out between August 2006 (date of burning) and August 2011 with the following objectives: [i] to study the changes in SWR and AS immediately after fire and in the medium-term (6 years after burning) and its distribution within aggregate size fractions (<2, 1-2, 0.5-1 and 0.25-0.5 mm), [ii] to assess the relationships between postfire AS and WR, and [iii] to investigate interactions between AS and WR and different factors (site, time since burning, lithology and vegetation type) in calcareous Mediterranean soils. METHODS Five areas affected by wildfires during summer 2006 were selected for this research. Vegetation was characterized by grassland and Mediterranean shrubland. Soils were calcareous, with loam to clayey texture. As shown from adjacent areas, soils were wettable or slightly water-repellent immediately before burning. Soil WR and AS were measured in soil samples (0-15 mm deep) in fine earth (<2 mm) and aggregate sieve fractions (1-2, 0.5-1 and 0.25-0.5 mm). WR was assessed using the WDPT test, and AS was determined as the percentage of stable aggregates after laboratory rainfall simulation. RESULTS Both properties showed different tendencies in different aggregate size fractions. Results showed that soil WR was induced in wettable soils or enhanced in slightly or moderately water-repellent soils after moderate severity burning. WR increased after fire especially in the finer fractions (0.25-0.5 mm) immediately after fire, and WR from finer aggregates (0.5-1 and 0.25-0.5 mm) varied or remained stable during the studied period, but did not contribute to general soil WR assessed in the fine earth fraction. AS increased significantly after the fire and was progressively reduced during the experimental period. Both properties returned progressively to pre-fire conditions during the study period. Soil resilience to low-moderate severity burning in the study area was very high. REFERENCES Gordillo-Rivero, A.J., García-Moreno, J., Jordán, A., Zavala, L.M. 2013. Monitoring fire impacts in soil water repellency and structure stability during 6 years. FLAMMA, 4(2):71-75.

Work reintegration after long-term sick leave: domains of influence on co-workers' ability to be supportive.

PubMed

Petersen, Kirsten Schultz; Labriola, Merete; Nielsen, Claus Vinther; Larsen, Eva Ladekjær

2016-09-01

The purpose of the study is to identify domains of influence on co-workers' ability to be supportive of returning worker during the work reintegration (WR) process. An ethnographic study design was chosen involving fieldwork at four different workplaces, at an emergency care service, a waste disposal company and at two nursing homes. Qualitative methods for inquiry were used including participant observation, individual- and group interviews of 30 participants. Data were coded and analysed according to a grounded theory approach. Four themes were identified related to domains of influence on co-workers' ability to be supportive of returning worker during the WR process: (1) organisation of work and level of interaction; (2) disruption of work routines, (3) relationship with returning worker and (4) attitudes towards sick leave. The WR process after long-term sick leave is not only influenced by the WR's arrangements made, but also by the co-workers' responses to the process. Work arrangements not only affect the returning worker's ability to return-to-work (RTW) successfully, but also the co-workers' ability to be supportive and their ability to take active part in the process. Implications for Rehabilitation The process of WR after long-term sick leave involves interaction with co-workers. Domains of influence is in the co-workers' perspective influencing their ability to be supportive during reintegration of a returning worker. Future WR management could benefit from integrating the conditions for co-worker support. We encourage co-workers to be involved in the RTW planning, monitoring and evaluation with particular focus on how the WR arrangements are influencing their work and their ability to be supportive.

Habitual exercise training in older adults offsets the age-related prolongation in leg vasodilator kinetics during single limb lower body exercise.

PubMed

Hughes, William E; Kruse, Nicholas T; Ueda, Kenichi; Casey, Darren P

2018-06-01

We tested the hypothesis that aging is associated with prolonged leg vasodilator kinetics and habitual exercise training in older adults improves these responses relative to untrained older adults. Additionally, we examined the relationship between contraction-induced rapid onset vasodilation (ROV) and vasodilator kinetics. Young (n=10), older untrained (n=13) and older trained (n=14) adults performed single and rhythmic knee-extension contractions at 20% and 40% work-rate maximum (WR max ). Femoral artery diameter and mean blood velocity were measured by Doppler ultrasound. Vascular conductance (VC; ml·min -1 ·mmHg-1) was calculated using blood flow (ml·min -1 ) and mean arterial pressure (mmHg). The primary outcome was the kinetic response (mean response time; MRT), modeled using an exponential model, expressed as the number of duty cycles to change 63% of the steady-state amplitude. There was no age or training related differences in VC MRT between the groups at 20% WR max . Older untrained adults exhibited prolonged VC MRT at 40% WR max relative to young (37{plus minus}16 vs. 24{plus minus}10 duty-cycles; P<0.05) and older trained adults (37{plus minus}16 vs. 23{plus minus}14 duty-cycles; P<0.05). There were no differences in VC MRT between young and older trained adults at 40% WR max (P=0.96). There were no associations between peak ROV and VC MRT at 20% or 40% WR max (r=-0.08 and 0.22; P=0.67 and 0.20, respectively) in the group as a whole. Our data suggest 1) advancing age prolongs leg vasodilator kinetics; 2) habitual exercise training in older adults offsets this age-related prolongation; and 3) contraction-induced ROV is not related to vasodilator kinetics within a group of young and older adults.

The recommended Threshold Limit Values for heat exposure fail to maintain body core temperature within safe limits in older working adults.

PubMed

Lamarche, Dallon T; Meade, Robert D; D'Souza, Andrew W; Flouris, Andreas D; Hardcastle, Stephen G; Sigal, Ronald J; Boulay, Pierre; Kenny, Glen P

2017-09-01

The American Conference of Governmental and Industrial Hygienists (ACGIH®) Threshold Limit Values (TLV® guidelines) for work in the heat consist of work-rest (WR) allocations designed to ensure a stable core temperature that does not exceed 38°C. However, the TLV® guidelines have not been validated in older workers. This is an important shortcoming given that adults as young as 40 years demonstrate impairments in their ability to dissipate heat. We therefore evaluated body temperature responses in older adults during work performed in accordance to the TLV® recommended guidelines. On three occasions, 9 healthy older (58 ± 5 years) males performed a 120-min work-simulated protocol in accordance with the TLV® guidelines for moderate-to-heavy intensity work (360 W fixed rate of heat production) in different wet-bulb globe temperatures (WBGT). The first was 120 min of continuous (CON) cycling at 28.0°C WBGT (CON[28°C]). The other two protocols were 15-min intermittent work bouts performed with different WR cycles and WBGT: (i) WR of 3:1 at 29.0°C (WR3:1[29°C]) and (ii) WR of 1:1 at 30.0°C (WR1:1[30°C]). Rectal temperature was measured continuously. The rate of change in mean body temperature was determined via thermometry (weighting coefficients: rectal, 0.9; mean skin temperature, 0.1) and direct calorimetry. Rectal temperature exceeded 38°C in all participants in CON[28°C] and WR3:1[29°C] whereas a statistically similar proportion of workers exceeded 38°C in WR1:1[30°C] (χ 2 ; P = 0.32). The average time for rectal temperature to reach 38°C was: CON[28°C], 53 ± 7; WR3:1[29°C], 79 ± 11; and WR1:1[30°C], 100 ± 29 min. Finally, while a stable mean body temperature was not achieved in any work condition as measured by thermometry (i.e., >0°C·min -1 ; all P<0.01), heat balance as determined by direct calorimetry was achieved in WR3:1[29°C] and WR1:1[30°C] (both P ≥ 0.08). Our findings indicate that the TLV® guidelines do not prevent body core temperature from exceeding 38°C in older workers. Furthermore, a stable core temperature was not achieved within safe limits (i.e., ≤38°C) indicating that the TLV® guidelines may not adequately protect all individuals during work in hot conditions.

Early alterations in soleus GLUT-4, glucose transport, and glycogen in voluntary running rats

NASA Technical Reports Server (NTRS)

Henriksen, Erik J.; Halseth, Amy E.

1994-01-01

Voluntary wheel running (WR) by juvenile female rats was used as a noninterventional model of soleus muscle functional overload to study the regulation of insulin-stimulated glucose transport activity by the glucose transporter (GLUT-4 isoform) protein level and glycogen concentration. Soleus total protein content was significantly greater (+18%;P greater than 0.05) than in age-matched controls after 1 wk of WR, and this hypertrophic response continued in weeks 2-4 (+24-32%). GLUT-4 protein was 39% greater than in controls in 1-wk WR soleus, and this adaptation was accompanied by a similar increase in in vitro insulin-stimulated glucose transport activity(+29%). After 2 and 4 wk of WR, however, insulin-stimulated glucose transport activity had returned to control levels, despite a continued elevation (+25-28%) of GLUT-4 protein. At these two time points, glycogen concentration was significantly enhanced in WR soleus (+21-42%), which coincided with significant reductions in glycogen synthase activity ratios (-23 to-41%). These results indicate that, in this model of soleus muscle functional overload, the GLUT-4 protein level may initially regulate insulin-stimulated glucose transport activity in the absence of changes in other modifying factors. However,this regulation of glucose transport activity by GLUT-4 protein may be subsequently overridden by elevated glycogen concentration.

Determination of the cytoprotective agent WR-2721 (Amifostine, Ethyol) and its metabolites in human blood using monobromobimane fluorescent labeling and high-performance liquid chromatography.

PubMed

Souid, A K; Newton, G L; Dubowy, R L; Fahey, R C; Bernstein, M L

1998-01-01

WR-2721 [S-2-(3-aminopropylamino)ethylphosphorothioic acid] is a chemoprotective agent that is currently in pediatric clinical trials. It is a prodrug that is dephosphorylated by alkaline phosphatase to the active free thiol form, WR-1065 [S-2-(3-aminopropylamino)ethanethiol]. It is likely that adequate and sustained cellular levels of the drug are necessary for optimum cytoprotection. To date, a method to measure both plasma and cellular levels of WR-2721 and its metabolites in clinical samples has not been available. In the study reported here the monobromobimane (mBBr) fluorescent labeling method was used to measure these levels when drug was added in vitro to blood samples from normal volunteers. In addition, we present pharmacokinetic data from a pediatric patient receiving WR-2721 (825 mg/m2 x 2). The results can be summarized as follows: (1) WR-2721 was detected in the patient's plasma with a half-life of about 10 min; (2) the WR-1065 concentration in the blood cellular fraction was similar to that of plasma; (3) both WR-1065 and WR-SS-low molecular weight (WR-SS-LMW) metabolites disappeared from plasma and the cellular fraction by 3.6 h after WR-2721 infusion; (4) a large proportion of WR-1065 was oxidized in plasma to WR-SS protein and WR-SS-LMW; (5) a large proportion of WR-1065 in the cellular fraction was oxidized to WR-SS-protein; (6) the WR-SS-LMW concentration in the cellular fraction was low; and (7) saturation of plasma and cellular protein binding sites was possible. The pharmacokinetic data that were generated with this technique could guide clinical trials using WR-2721.

Estrellas Wolf-Rayet y el medio interestelar: huellas de una fuerte interacción

NASA Astrophysics Data System (ADS)

Cichowolski, S.; Arnal, E. M.

Se presentan resultados observacionales de un estudio de la distribución de hidrógeno neutro en los alrededores de estrellas Wolf-Rayet (WR) galácticas. Los datos de la línea de 21 cm provienen de observaciones de resolución angular intermedia (9') tomadas con el radiotelescopio de Effelsberg. La muestra está compuesta por cuatro WR de la serie del nitrógeno (WN): WR130, WR131, WR155, WR156 y tres WR de la serie del carbono (WC): WR154, WR117 y WR126. Este análisis ha permitido detectar cavidades y envolturas de HI en expansión presumiblemente vinculadas a dichas estrellas.

Wheel running reduces ethanol seeking by increasing neuronal activation and reducing oligodendroglial/neuroinflammatory factors in the medial prefrontal cortex

PubMed Central

Somkuwar, Sucharita S.; Fannon, McKenzie J.; Ghofranian, Atoosa; Quigley, Jacqueline A.; Dutta, Rahul R.; Galinato, Melissa H.; Mandyam, Chitra D.

2016-01-01

The therapeutic effects of wheel running (WR) during abstinence on reinstatement of ethanol seeking behaviors in rats that self-administered ethanol only (ethanol drinking, ED) or ED with concurrent chronic intermittent ethanol vapor experience (CIE-ED) were investigated. Neuronal activation as well as oligodendroglial and neuroinflammatory factors were measured in the medial prefrontal cortex (mPFC) tissue to determine cellular correlates associated with enhanced ethanol seeking. CIE-ED rats demonstrated escalated and unregulated intake of ethanol and maintained higher drinking than ED rats during abstinence. CIE-ED rats were more resistant to extinction from ethanol self-administration, however, demonstrated similar ethanol seeking triggered by ethanol contextual cues compared to ED rats. Enhanced seeking was associated with reduced neuronal activation, and increased number of myelinating oligodendrocyte progenitors and PECAM-1 expression in the mPFC, indicating enhanced oligodendroglial and neuroinflammatory response during abstinence. WR during abstinence enhanced self-administration in ED rats, indicating a deprivation effect. WR reduced reinstatement of ethanol seeking in CIE-ED and ED rats, indicating protection against relapse. The reduced ethanol seeking was associated with enhanced neuronal activation, reduced number of myelinating oligodendrocyte progenitors, and reduced PECAM-1 expression. The current findings demonstrate a protective role of WR during abstinence in reducing ethanol seeking triggered by ethanol contextual cues and establish a role for oligodendroglia-neuroinflammatory response in ethanol seeking. Taken together, enhanced oligodendroglia-neuroinflammatory response during abstinence may contribute to brain trauma in chronic alcohol drinking subjects and be a risk factor for enhanced propensity for alcohol relapse. PMID:27542327

Mg II Absorption at 2 < Z < 7 with Magellan/Fire. III. Full Statistics of Absorption toward 100 High-redshift QSOs

NASA Astrophysics Data System (ADS)

Chen, Shi-Fan S.; Simcoe, Robert A.; Torrey, Paul; Bañados, Eduardo; Cooksey, Kathy; Cooper, Tom; Furesz, Gabor; Matejek, Michael; Miller, Daniel; Turner, Monica; Venemans, Bram; Decarli, Roberto; Farina, Emanuele P.; Mazzucchelli, Chiara; Walter, Fabian

2017-12-01

We present statistics from a survey of intervening Mg II absorption toward 100 quasars with emission redshifts between z = 3.55 and z = 7.09. Using infrared spectra from Magellan/FIRE, we detect 280 cosmological Mg II absorbers, and confirm that the comoving line density of {W}r> 0.3 \\mathringA Mg II absorbers does not evolve measurably between z = 0.25 and z = 7. This is consistent with our detection of seven Mg II systems at z> 6, redshifts not covered in prior searches. Restricting to systems with {W}r> 1 Å, there is significant evidence for redshift evolution. These systems roughly double in density between z = 0 and z = 2-3, but decline by an order of magnitude from this peak by z˜ 6. This evolution mirrors that of the global star formation rate density, potentially reflecting a connection between star formation feedback and the strong Mg II absorbers. We compared our results to the Illustris cosmological simulation at z = 2-4 by assigning absorption to cataloged dark matter halos and by direct extraction of spectra from the simulation volume. Reproducing our results using the former requires circumgalactic Mg II envelopes within halos of progressively smaller mass at earlier times. This occurs naturally if we define the lower integration cutoff using SFR rather than mass. Spectra calculated directly from Illustris yield too few strong Mg II absorbers. This may arise from unresolved phase space structure of circumgalactic gas, particularly from spatially unresolved turbulent or bulk motions. The presence of circumgalactic magnesium at z> 6 suggests that enrichment of intra-halo gas may have begun before the presumed host galaxies’ stellar populations were mature and dynamically relaxed. This paper includes data gathered with the 6.5 m Magellan Telescopes located at Las Campanas Observatory, Chile.

Exercise Thresholds on Trial: Are They Really Equivalent?

PubMed

Caen, Kevin; Vermeire, Kobe; Bourgois, Jan G; Boone, Jan

2018-06-01

The interchangeable use of whole-body exercise thresholds and breakpoints (BP) in the local oxygenation response, as measured via near-infrared spectroscopy, has recently been questioned in scientific literature. Therefore, the present study aimed to longitudinally investigate the interrelationship of four commonly used exercise thresholds: critical power (CP), the respiratory compensation point (RCP), and BP in muscle (m[HHb]BP) and brain (c[O2Hb]BP) oxygenation. Nine male participants (21.8 ± 1.2 yr) completed 6 wk of cycling interval training. Before and after this intervention period, subjects performed a ramp incremental exercise protocol to determine RCP, m[HHb]BP, and c[O2Hb]BP and four constant work rate (WR) tests to calculate CP. WR associated with CP, RCP, m[HHB]BP, and c[O2Hb]BP increased by 7.7% ± 4.2%, 13.6% ± 9.0%, 9.8% ± 5.7%, and 11.3% ± 11.1%, respectively. CP was lower (pre: 260 ± 32 W, post: 280 ± 41 W; P < 0.05) than the WR associated with RCP (pre: 281 ± 28 W, post: 318 ± 36 W) and c[O2Hb]BP (pre: 283 ± 36 W, post: 313 ± 32 W) which occurred concomitantly (P = 0.683). M[HHb]BP occurred at the highest WR and differed from all others (pre: 313 ± 23 W, post: 344 ± 32 W; P < 0.05). Training-induced WR differences (ΔWR) did not contrast between thresholds, and initial parameter differences were not affected by the intervention (P = 0.253). Thresholds were partly correlated before (R = 0.67-0.85, P < 0.05) and after (R = 0.83-0.96, P < 0.05) training, but ΔWR values were not associated (P > 0.05). Results of the present study strongly question true equivalence of CP, RCP, m[HHb]BP, and c[O2Hb]BP during ramp incremental exercise. Therefore, these exercise thresholds should not be used interchangeably.

Long-slit optical spectroscopy of powerful far-infrared galaxies - The nature of the nuclear energy source

NASA Technical Reports Server (NTRS)

Armus, Lee; Heckman, Timothy M.; Miley, George K.

1989-01-01

Optical spectroscopic data are presented for a sample of 47 powerful far-IR galaxies chosen for IR spectral shape, and for six other IR-bright galaxies. The stellar absorption lines expected from a population of old stars are generally very weak in the nuclei of the galaxies. Very weak Mg I absorption is found in regions well off the nucleus, implying that the visible spectrum is dominated by young stars and not by an AGN. At least one, and probably five, of the galaxies have detectable WR emission features, providing additional evidence for a young stellar population. About 20 percent of the galaxies have strong Balmer absorption lines, indicating the presence of a substantial intermediate-age stellar population. The equivalent width of the H-alpha emission line can be modeled as arising from a mixture of a large young population and an intermediate-age population of stars.

The CHARA Array resolves the long-period Wolf-Rayet binaries WR 137 and WR 138

NASA Astrophysics Data System (ADS)

Richardson, Noel D.; Shenar, Tomer; Roy-Loubier, Olivier; Schaefer, Gail; Moffat, Anthony F. J.; St-Louis, Nicole; Gies, Douglas R.; Farrington, Chris; Hill, Grant M.; Williams, Peredur M.; Gordon, Kathryn; Pablo, Herbert; Ramiaramanantsoa, Tahina

2016-10-01

We report on interferometric observations with the CHARA Array of two classical Wolf-Rayet (WR) stars in suspected binary systems, namely WR 137 and WR 138. In both cases, we resolve the component stars to be separated by a few milliarcseconds. The data were collected in the H band, and provide a measure of the fractional flux for both stars in each system. We find that the WR star is the dominant H-band light source in both systems (fWR,137 = 0.59 ± 0.04; fWR,138 = 0.67 ± 0.01), which is confirmed through both comparisons with estimated fundamental parameters for WR stars and O dwarfs, as well as through spectral modelling of each system. Our spectral modelling also provides fundamental parameters for the stars and winds in these systems. The results on WR 138 provide evidence that it is a binary system which may have gone through a previous mass-transfer episode to create the WR star. The separation and position of the stars in the WR 137 system together with previous results from the IOTA interferometer provides evidence that the binary is seen nearly edge-on. The possible edge-on orbit of WR 137 aligns well with the dust production site imaged by the Hubble Space Telescope during a previous periastron passage, showing that the dust production may be concentrated in the orbital plane.

Wolf-Rayet stars

NASA Technical Reports Server (NTRS)

Abbott, David C.; Conti, Peter S.

1987-01-01

The properties and evolutionary status of WR stars are examined, reviewing the results of recent observational and theoretical investigations. Topics discussed include spectral types and line strengths, magnitudes and colors, intrinsic variability, IR and radio observations, X-ray observations, the Galactic distribution of WR stars, WR stars in other galaxies, and WR binaries. Consideration is given to the inferred masses, composition, and stellar winds of WR stars; model atmospheres; WR stars and the Galactic environment; and WR stars as a phase of stellar evolution. Diagrams, graphs, and tables of numerical data are provided.

The spectra of WC9 stars: evolution and dust formation

NASA Astrophysics Data System (ADS)

Williams, P. M.; Crowther, P. A.; van der Hucht, K. A.

2015-05-01

We present analyses of new optical spectra of three WC9 stars, WR 88, WR 92 and WR 103 to test the suggestion that they exemplify an evolutionary sequence amongst the WC9 stars. The spectrum of WR 88 shows conspicuous lines of N III and N IV, leading to classification as a transitional WN8o/WC9 star. The three stars show a sequence of increasing O II and O III line strengths, confirming and extending earlier studies. The spectra were analysed using CMFGEN models, finding greater abundances of oxygen and carbon in WR 103 than in WR 92 and, especially, in WR 88. Of the three stars, only WR 103 makes circumstellar dust. We suggest that oxygen itself does not enhance this process but that it is its higher carbon abundance that allows WR 103 to make dust.

THE PREVALENCE AND IMPACT OF WOLF–RAYET STARS IN EMERGING MASSIVE STAR CLUSTERS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sokal, Kimberly R.; Johnson, Kelsey E.; Indebetouw, Rémy

We investigate Wolf–Rayet (WR) stars as a source of feedback contributing to the removal of natal material in the early evolution of massive star clusters. Despite previous work suggesting that massive star clusters clear out their natal material before the massive stars evolve into the WR phase, WR stars have been detected in several emerging massive star clusters. These detections suggest that the timescale for clusters to emerge can be at least as long as the time required to produce WR stars (a few million years), and could also indicate that WR stars may be providing the tipping point inmore » the combined feedback processes that drive a massive star cluster to emerge. We explore the potential overlap between the emerging phase and the WR phase with an observational survey to search for WR stars in emerging massive star clusters hosting WR stars. We select candidate emerging massive star clusters from known radio continuum sources with thermal emission and obtain optical spectra with the 4 m Mayall Telescope at Kitt Peak National Observatory and the 6.5 m MMT.{sup 4} We identify 21 sources with significantly detected WR signatures, which we term “emerging WR clusters.” WR features are detected in ∼50% of the radio-selected sample, and thus we find that WR stars are commonly present in currently emerging massive star clusters. The observed extinctions and ages suggest that clusters without WR detections remain embedded for longer periods of time, and may indicate that WR stars can aid, and therefore accelerate, the emergence process.« less

The East Atlantic - West Russia Teleconnection in the North Atlantic: Climate Impact and Relation to Rossby Wave Propagation

NASA Technical Reports Server (NTRS)

Lim, Young-Kwon

2014-01-01

Large-scale winter teleconnection of the East Atlantic - West Russia (EA-WR) over the Atlantic and surrounding regions is examined in order to quantify its impacts on temperature and precipitation and identify the physical mechanisms responsible for its existence. A rotated empirical orthogonal function (REOF) analysis of the upper-tropospheric monthly height field captures successfully the EA-WR pattern and its interannual variation, with the North Atlantic Oscillation as the first mode. EA-WRs climate impact extends from eastern North America to Eurasia. The positive (negative) EA-WR produces positive (negative) temperature anomalies over the eastern US, western Europe and Russia east of Caspian Sea, with negative (positive) anomalies over eastern Canada, eastern Europe including Ural Mountains and the Middle East. These anomalies are largely explained by lower-tropospheric temperature advections. Positive (negative) precipitation anomalies are found over the mid-latitude Atlantic and central Russia around 60E, where lower-level cyclonic (anticyclonic) circulation anomaly is dominant. The eastern Canada and the western Europe are characterized by negative (positive) precipitation anomalies.The EA-WR is found to be closely associated with Rossby wave propagation. Wave activity fluxes show that it is strongly tied to large-scale stationary waves. Furthermore, a stationary wave model (SWM) forced with vorticity transients in the mid-latitude Atlantic (approximately 40N) or diabatic heat source over the subtropical Atlantic near the Caribbean Sea produces well-organized EA-WR-like wave patterns, respectively. Sensitivity tests with the SWM indicate improvement in the simulation of the EA-WR when the mean state is modified to have a positive NAO component that enhances upper-level westerlies between 40-60N.

WR279,396, a Third Generation Aminoglycoside Ointment for the Treatment of Leishmania major Cutaneous Leishmaniasis: A Phase 2, Randomized, Double Blind, Placebo Controlled Study

PubMed Central

Morizot, Gloria; Ben Massoud, Nathalie; Zâatour, Amor; Ben Alaya, Nissaf; Haj Hamida, Nabil Bel; Ahmadi, Zaher El; Downs, Matthew T.; Smith, Philip L.; Dellagi, Koussay; Grögl, Max

2009-01-01

Background Cutaneous leishmaniasis (CL) is a disfiguring disease that confronts clinicians with a quandary: leave patients untreated or engage in a complex or toxic treatment. Topical treatment of CL offers a practical and safe option. Accordingly, the treatment of CL with WR279,396, a formulation of paromomycin and gentamicin in a hydrophilic base, was investigated in a phase 2 clinical study in Tunisia and France. Methods A phase 2, randomized, double blind, vehicle-controlled study was conducted to assess the safety and efficacy of topical WR279,396 when applied twice a day for 20 days as treatment for parasitologically confirmed CL. The study protocol established the primary efficacy end point as complete clinical response (CCR) defined as 50% or greater reduction in the ulceration size of an index lesion by day 50 (D50) followed by complete re-epithelialization by D100, and no relapse through D180. Results Ninety-two subjects were randomized. Leishmania major was identified in 66 of 68 isolates typed (97%). In the intent-to-treat population, 47 of 50 WR279,396 treated participants (94%) met the definition of CCR, compared with 30 of 42 vehicle-placebo participants (71%) [p = 0.0045]. Erythema occurred in 30% and 24% of participants receiving WR279,396 and placebo, respectively [p = 0.64]. There was no clinical or laboratory evidence of systemic toxicity. Conclusion Application of WR279,396 for 20 days was found to be safe and effective in treating L. major CL, and offers great potential as a new, simple, easily applicable, and inexpensive topical therapy for this neglected disease. Trial Registration ClinicalTrials.gov NCT00703924 PMID:19415122

Successful Application of Low Loss, Over-Moded WR-187 Waveguide to the ASDE-3 Radar

DOT National Transportation Integrated Search

1982-04-01

Overmoded WR-187 waveguide has been incorporated into the short-range ASDE-3 system to provide a low-loss interconnection between the antenna and the transmitter/receiver. WR-62 to WR-187 transitions and WR-187 mode suppressors were developed specifi...

Protection of mice against fission-neutron irradiation by WR-2721 or WR-151327

DOE Office of Scientific and Technical Information (OSTI.GOV)

Steel, L.K.; Jacobs, A.J.; Giambarresi, L.I.

1987-01-01

Two phosphorothioate compounds, WR-2721 and WR-151327, were examined for their radioprotective efficacies against the effects of fission-neutron irradiation in male and female mice. Within sex groups no significant difference in lethality at 30 or 100 days postirradiation was found between WR-2721 or WR-151327 pretreatment. The dose-modification factors (DMFs) for male mice treated with either compound were 1.29 (LD50/30) and 1.24 (LD50/100), and those for drug-treated female mice were 1.21 (LD50/30) and 1.19 (LD50/100). Both WR-2721 and WR-151327 were found to be equally radioprotective when compared using DMFs as the end point. WR-151327 were found to be equally radioprotective when comparedmore » using DMFs as the end point. WR-151327 (500 mg/kg, ip) was found to be significantly more toxic to both male and female B6D2F1 mice than equimolar amounts of WR-2721. Small but significant sex differences in radioprotection were found: the DMFs for female mice pretreated with either compound were lower than those for similarly treated male mice; the incidence of mortality 31-100 days postexposure in male mice pretreated with WR-151327 was greater than for female mice. In addition, sex differences were noted in drug toxicity. Toxic death in female mice given WR-151327 (500 mg/kg, ip) is 2.6 times more probable than in males.« less

Abnormal relationships between the neural response to high- and low-calorie foods and endogenous acylated ghrelin in women with active and weight-recovered anorexia nervosa

PubMed Central

Holsen, Laura M.; Lawson, Elizabeth A.; Christensen, Kara; Klibanski, Anne; Goldstein, Jill M.

2014-01-01

Evidence contributing to the understanding of neurobiological mechanisms underlying appetite dysregulation in anorexia nervosa draws heavily on separate lines of research into neuroendocrine and neural circuitry functioning. In particular, studies consistently cite elevated ghrelin and abnormal activation patterns in homeostatic (hypothalamus) and hedonic (striatum, amygdala, insula) regions governing appetite. The current preliminary study examined the interaction of these systems, based on research demonstrating associations between circulating ghrelin levels and activity in these regions in healthy individuals. In a cross-sectional design, we studied 13 women with active anorexia nervosa (AN), 9 women weight-recovered from AN (AN-WR), and 12 healthy-weight control women using a food cue functional magnetic resonance imaging paradigm, with assessment of fasting levels of acylated ghrelin. Healthy-weight control women exhibited significant positive associations between fasting acylated ghrelin and activity in the right amygdala, hippocampus, insula, and orbitofrontal cortex in response to high-calorie foods, associations which were absent in the AN and AN-WR groups. Women with AN-WR demonstrated a negative relationship between ghrelin and activity in the left hippocampus in response to high-calorie foods, while women with AN showed a positive association between ghrelin and activity in the right orbitofrontal cortex in response to low-calorie foods. Findings suggest a breakdown in the interaction between ghrelin signaling and neural activity in relation to reward responsivity in AN, a phenomenon that may be further characterized using pharmacogenetic studies. PMID:24862390

Protection of mice against fission neutron irradiation by WR-2721 or WR-151327

DOE Office of Scientific and Technical Information (OSTI.GOV)

Steel, L.K.; Jacobs, A.J.; Giambarresi, L.I.

1987-03-01

Two phosphorothioate compounds, WR-2721 and WR-151327, were examined for their radioprotective efficacies against the effects of fission neutron irradiation in male and female mice. Within sex groups no significant difference in lethality at 30 or 100 days postirradiation was found between WR-2721 or WR-151327 pretreatment. The dose modification factors (DMFs) for male mice treated with either compound were 1.29 (LD50/30) and 1.24 (LD50/100), and those for drug-treated female mice were 1.21 (LD50/30) and 1.19 (LD50/100). Both WR-2721 and WR-151327 were found to be equally radioprotective when compared using DMFs as the end point. WR-151327 (500 mg/kg, ip) was found tomore » be significantly more toxic to both male and female B6D2F1 mice than equimolar amounts of WR-2721. Small but significant sex differences in radioprotection were found: the DMFs for female mice pretreated with either compound were lower than those for similarly treated male mice; the incidence of mortality 31-100 days postexposure in male mice pretreated with WR-151327 was greater than for female mice. In addition, sex differences were noted in drug toxicity. Toxic death in female mice given WR-151327 (500 mg/kg, ip) is 2.6 times more probable than in males.« less

Survey of selected pathogens and blood parameters of northern yellowstone elk: Wolf sanitation effect implications

USGS Publications Warehouse

Barber-Meyer, S. M.; White, P.J.; Mech, L.D.

2007-01-01

The restoration or conservation of predators could reduce seroprevalences of certain diseases in prey if predation selectively removes animals exhibiting clinical signs. We assessed disease seroprevalences and blood parameters of 115 adult female elk (Cervus elaphus) wintering on the northern range of Yellowstone National Park [YNP] during 2000-2005 and compared them to data collected prior to wolf (Canis lupus) restoration (WR) in 1995 and to two other herds in Montana to assess this prediction. Blood parameters were generally within two standard deviations of the means observed in other Montana herds (Gravelly-Snowcrest [GS] and Garnet Mountain [GM]), but Yellowstone elk had higher seroprevalences of parainfluenza-3 virus (95% CI YNP = 61.1-78.6, GS = 30.3-46.5) and bovine-virus-diarrhea virus type 1 (95% CI YNP = 15.9-31.9, GM = 0). In comparisons between pre-wolf restoration [pre-WR] (i.e., prior to 1995) seroprevalences with those post-wolf restoration [post-WR] in Yellowstone, we found lower seroprevalences for some disease-causing agents post-wolf restoration (e.g., bovine-virus-diarrhea virus type-1 [95% CI pre-WR = 73.1-86.3, post-WR = 15.9-31.9] and bovine-respiratory syncytial virus [95% CI pre-WR = 70.0-83.8, post-WR = 0]), but similar (e.g., Brucella abortus [95% CI pre-WR = 0-4.45, post-WR = 0-4.74] and epizootic hemorrhagic disease virus [95% CI pre-WR = 0, post-WR = 0]) or higher for others (e.g., Anaplasma marginale [95% CI pre-WR = 0, post-WR = 18.5-38.7] and Leptospira spp. [95% CI pre-WR = 0.5-6.5, post-WR = 9.5-23.5]). Though we did not detect an overall strong predation effect through reduced disease seroprevalence using retrospective comparisons with sparse data, our reference values will facilitate future assessments of this issue.

AFRRI (Armed Forces Radiobiology Research Institute) reports, October, January-March 1989. Technical report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1989-01-01

Contents include: effects of ethiofos (WR-2721) and radiation on monkey visual discrimination performance; gamma radiolysis of RNA: an ESR and spin-trapping study; phospholipid storage in the secretory granule of the mast cell; physiological localization of an agonist-sensitive pool of Ca{sup 2+} in parotid acinar cells; changes in canine neutrophil function(s) following cellular isolation by percoll gradient centrifugation or isotoniclysis; impaired repair of uvc-induced DNA damage in l5178Y-R cells: sedimentation studies with the use of 5'-bromodeoxyuridine photolysis; comparative behavioral toxicity of four sulfhydryl radioprotective compounds in mice: WR-2721, cysteamine, diethyldithiocarbamate, and n-acetylcysteine; measurement of the radiosensitivity of rat marrow by flowmore » cytometry; radioprotection by biological response modifiers alone and in combination with WR-2721; postirradiation glucan administration enhances the radioprotective effects of WR-2721; attenuation and cross-attenuation in taste aversion learning in the rat: studies with ionizing radiation, lithium chloride, and ethanol; a low-energy x-ray irradiator for electrophysiological studies; thermospray liquid chromatography mass spectrometry of thiol radioprotective agents: characteristic spectra; radioprotection by leukotrienes: is there a receptor mechanism and a low-energy x-ray irradiator for electrophysiological studies.« less

The relative importance of hydrophobicity in determining runoff-infiltration processes in burned forest soils

NASA Astrophysics Data System (ADS)

Wittenberg, Lea; Malkinson, Dan; Voogt, Annelies; Leska, Danny; Argaman, Eli; Keesstra, Saskia

2010-05-01

Wildfires induce fundamental changes to vegetation and soil structure/texture which conseqeuntly have major impacts on infiltration capacity, overland flow generation, runoff and sediment yields. The relative importance, however, of fire-induced soil water repellency (WR) on hydrological and erosional processes is somewhat controversial, partially, as the direct effects of soil WR in-situ field conditions have been difficult to isolate. It is generally accepted that hydrophobicity is caused by the formation of organic substances in forest soils, while burning is considered to enhance this process. Given the complex response of the soil-vegetation system to burning, soil WR is only one of several affecting soil hydrology. Other factors include the physical sealing of soils triggered by rain drops energy, the increase in soil erodibility due to changes in soil aggregates, and the role of the ash in sealing the burned surface. The degree and spatial distribution of WR burned varies considerably with fire severity, soil and vegetation type, soil moisture content and time since burning. Nevertheless, given the inverse relationship between soil moisture and hydrophobicity, the role of the latter in determining overland flow during wet winters when the soil is mostly inundated, is marginal. Following a 60 ha wildfire, which took place at the Pe'eram catchment during July 2009, we assessed the spatio-temporal distribution of WR in a burned Pinus halepensis forest. The site, located in the Upper Galille, Israel, was severely burned; the combustion removed all understory vegetation and burned down some of the trunks, leaving a thick layer of ash. The soils composed of reddish-brown clay loam forest soil and terra rossa on limestone bedrock, greyish light rendzina characterises the marl and chalk exposures. To consider the effect of distance from trees, in-situ hydrophobicity was assessed within a week, month and five months after the fire, using the WDPT test. Measurements were taken in concentric circles around the burned trees at two soil depths. We complemented this investigation by conducting a series of laboratory simulations. Non-burned soil was taken for laboratory analysis and rainfall simulations. Four treatment types were conducted: non-burned soil, non-burned soil + pine needles, burned soil without ash (300°C/15 min. after adding pine needles) and burned soil with the residue ash (300°C/15 min. after adding pine needles). Hydrophobicity was measured in all trays. Constant rainfall intensity of 30 mm/hr was simulated until terminal infiltration rates were reached. The experimental trays were oven dried and simulated again to imitate the effect of second rainstorm. Preliminary results indicate strong surface WR (60% >180s) at a distance of 1m and at the subsurface (50% >180s) directly by the trunk. In the control non-burned site stronger WR was found in proximity to the trunks. While in the burned sites extreme values (>300s) were apparent (15-35%) and correlated with distance from the trunk, no corresponding patterns were noticed in the control trees. The attempt to create homogeneous layer of WR under controlled laboratory conditions yielded a scattered pattern of repellency, similar to the field conditions. In contrast to expected, the bare soil and bare soil covered by needles exhibited the highest and lowest infiltration rates, respectively, while the burned hydrophobic soils demonstrated intermediate rates. It is thus suggested that in some soils, WR might enhance infiltration capacity by creating a complex mosaic of runoff-generating and runoff-absorbing micro-patches. In the experimental non-burned soil a rapid crusting of the surface provided lateral connectivity whilst the accumulation of litter and organic matter blanket the surface and enhance the vertical conductivity. To better understand the role of WR in generating hydrological response, it is required to consider the 3D 'sponge like' properties of the WR soils.

The highly ionized, high-velocity gas in NGC 6231

NASA Astrophysics Data System (ADS)

Massa, Derck

2017-02-01

It is well known that clusters of massive stars are influenced by the presence of strong winds, that they are sources of diffuse X-rays from shocked gas, and that this gas can be vented into the surrounding region or the halo through the champagne effect. However, the details of how these different environments interact and evolve are far from complete. This paper attributes the broad C IVλλ1500 absorption features (extending to -1900 km s-1) that are seen in the spectra of main sequence B stars in NGC 6231 to gas in the cluster environment and not the B stars themselves. It is shown that the presence of a WC star, WR 79, in the cluster makes this gas detectable because its wind enriches the cluster gas with carbon. Given the available data, it is not clear whether the absorbing gas is simply the far wind of WR 79 or a collective cluster wind enriched by carbon from the wind of WR 79. If it is simply due to the wind, then this wind must flow, unimpeded for more than 2 pc, suggesting that the inner region of the cluster is nearly devoid of obstructing material. If it is actually a collective wind from the cluster, then we could be witnessing an important stage of galactic feedback. In either case, the observations provide a unique and significant piece to the puzzle of how massive, open clusters evolve.

WR 148 and the not so compact companion

NASA Astrophysics Data System (ADS)

Munoz, Melissa; Moffat, Anthony J.; Hill, Grant M.; Shenar, Tomer; Richardson, Noel D.; Pablo, Herbert; St-Louis, Nicole; Ramiaramanantsoa, Tahina

2017-11-01

The objective is to determine the nature of the unseen companion of the single-lined spectroscopic binary, WR 148 (= WN7h+?). The absence of companion lines supports a compact companion (cc) scenario. The lack of hard X-rays favours a non-compact companion scenario. Is WR 148 a commonplace WR+OB binary or a rare WR+cc binary?

WR 120bb and WR 120bc: a pair of WN9h stars with possibly interacting circumstellar shells

NASA Astrophysics Data System (ADS)

Burgemeister, S.; Gvaramadze, V. V.; Stringfellow, G. S.; Kniazev, A. Y.; Todt, H.; Hamann, W.-R.

2013-03-01

Two optically obscured Wolf-Rayet (WR) stars have been recently discovered by means of their infrared (IR) circumstellar shells, which show signatures of interaction with each other. Following the systematics of the WR star catalogues, these stars obtain the names WR 120bb and WR 120bc. In this paper, we present and analyse new near-IR, J-, H- and K-band spectra using the Potsdam Wolf-Rayet model atmosphere code. For that purpose, the atomic data base of the code has been extended in order to include all significant lines in the near-IR bands. The spectra of both stars are classified as WN9h. As their spectra are very similar the parameters that we obtained by the spectral analyses hardly differ. Despite their late spectral subtype, we found relatively high stellar temperatures of 63 kK. The wind composition is dominated by helium, while hydrogen is depleted to 25 per cent by mass. Because of their location in the Scutum-Centaurus Arm, WR 120bb and WR 120bc appear highly reddened, A_{K_s} ≈ 2 mag. We adopt a common distance of 5.8 kpc to both stars, which complies with the typical absolute K-band magnitude for the WN9h subtype of -6.5 mag, is consistent with their observed extinction based on comparison with other massive stars in the region, and allows for the possibility that their shells are interacting with each other. This leads to luminosities of log ({textit {L}/L}_{odot }) = 5.66 and 5.54 for WR 120bb and WR 120bc, with large uncertainties due to the adopted distance. The values of the luminosities of WR 120bb and WR 120bc imply that the immediate precursors of both stars were red supergiants (RSG). This implies in turn that the circumstellar shells associated with WR 120bb and WR 120bc were formed by interaction between the WR wind and the dense material shed during the preceding RSG phase.

How do Swedish day center attendees with psychiatric disabilities view their worker role? A structural equation modeling study.

PubMed

Eklund, Mona; Bäckström, Martin; Bejerholm, Ulrika

2018-05-01

To investigate how day center attendees with psychiatric disabilities perceived their worker role and the importance of current work situation and personal factors in that respect. Two-hundred attendees completed the Worker Role Self-assessment and questionnaires addressing possible predictors of the worker role: current employment situation, satisfaction with that situation, and a personal factor (encompassing self-esteem, self-mastery and engagement). Structural equation modeling was used. A model indicated two worker role factors; belief in a future worker role (WR1) and current capacities and routines (WR2). WR1 was positively influenced by having a job, younger age and the personal factor. Satisfaction with current work situation (usually unemployment) was negatively associated with WR1. The personal factor was single predictor of WR2. The attendees rated WR2 more positively than WR1. The personal factor was crucial for both WR1 and WR2. Work-related factors were only important for WR1. The more negative rating of belief in a future worker role may be interpreted as mistrust in the services. The attendees' positive ratings of capacities indicate, however, that they had a rehabilitation potential to develop. Enhancing self-esteem, mastery and engagement may be an avenue for staff in efforts to support the attendee's worker role.

Abnormal relationships between the neural response to high- and low-calorie foods and endogenous acylated ghrelin in women with active and weight-recovered anorexia nervosa.

PubMed

Holsen, Laura M; Lawson, Elizabeth A; Christensen, Kara; Klibanski, Anne; Goldstein, Jill M

2014-08-30

Evidence contributing to the understanding of neurobiological mechanisms underlying appetite dysregulation in anorexia nervosa draws heavily on separate lines of research into neuroendocrine and neural circuitry functioning. In particular, studies consistently cite elevated ghrelin and abnormal activation patterns in homeostatic (hypothalamus) and hedonic (striatum, amygdala, insula) regions governing appetite. The current preliminary study examined the interaction of these systems, based on research demonstrating associations between circulating ghrelin levels and activity in these regions in healthy individuals. In a cross-sectional design, we studied 13 women with active anorexia nervosa (AN), 9 women weight-recovered from AN (AN-WR), and 12 healthy-weight control women using a food cue functional magnetic resonance imaging paradigm, with assessment of fasting levels of acylated ghrelin. Healthy-weight control women exhibited significant positive associations between fasting acylated ghrelin and activity in the right amygdala, hippocampus, insula, and orbitofrontal cortex in response to high-calorie foods, associations which were absent in the AN and AN-WR groups. Women with AN-WR demonstrated a negative relationship between ghrelin and activity in the left hippocampus in response to high-calorie foods, while women with AN showed a positive association between ghrelin and activity in the right orbitofrontal cortex in response to low-calorie foods. Findings suggest a breakdown in the interaction between ghrelin signaling and neural activity in relation to reward responsivity in AN, a phenomenon that may be further characterized using pharmacogenetic studies. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

Spatial distribution of Galactic Wolf-Rayet stars and implications for the global population

NASA Astrophysics Data System (ADS)

Rosslowe, C. K.; Crowther, P. A.

2015-03-01

We construct revised near-infrared absolute magnitude calibrations for 126 Galactic Wolf-Rayet (WR) stars at known distances, based in part upon recent large-scale spectroscopic surveys. Application to 246 WR stars located in the field permits us to map their Galactic distribution. As anticipated, WR stars generally lie in the thin disc (˜40 pc half-width at half-maximum) between Galactocentric radii 3.5-10 kpc, in accordance with other star formation tracers. We highlight 12 WR stars located at vertical distances of ≥300 pc from the mid-plane. Analysis of the radial variation in WR subtypes exposes a ubiquitously higher NWC/NWN ratio than predicted by stellar evolutionary models accounting for stellar rotation. Models for non-rotating stars or accounting for close binary evolution are more consistent with observations. We consolidate information acquired about the known WR content of the Milky Way to build a simple model of the complete population. We derive observable quantities over a range of wavelengths, allowing us to estimate a total number of 1900 ± 250 Galactic WR stars, implying an average duration of ˜ 0.4 Myr for the WR phase at the current Milky Way star formation rate. Of relevance to future spectroscopic surveys, we use this model WR population to predict follow-up spectroscopy to KS ≃ 17.5 mag will be necessary to identify 95 per cent of Galactic WR stars. We anticipate that ESA's Gaia mission will make few additional WR star discoveries via low-resolution spectroscopy, though will significantly refine existing distance determinations. Appendix A provides a complete inventory of 322 Galactic WR stars discovered since the VIIth catalogue (313 including Annex), including a revised nomenclature scheme.

Uncovering multiple Wolf-Rayet star clusters and the ionized ISM in Mrk 178: the closest metal-poor Wolf-Rayet H II galaxy

NASA Astrophysics Data System (ADS)

Kehrig, C.; Pérez-Montero, E.; Vílchez, J. M.; Brinchmann, J.; Kunth, D.; García-Benito, R.; Crowther, P. A.; Hernández-Fernández, J.; Durret, F.; Contini, T.; Fernández-Martín, A.; James, B. L.

2013-07-01

New integral field spectroscopy (IFS) has been obtained for the nearby metal-poor Wolf-Rayet (WR) galaxy Mrk 178 to examine the spatial correlation between its WR stars and the neighbouring ionized interstellar medium (ISM). The strength of the broad WR features and its low metallicity make Mrk 178 an intriguing object. We have detected the blue and red WR bumps in different locations across the field of view (˜300 pc × 230 pc) in Mrk 178. The study of the WR content has been extended, for the first time, beyond its brightest star-forming knot uncovering new WR star clusters. Using Large/Small Magellanic Cloud-template WR stars, we empirically estimate a minimum of ˜20 WR stars within the region sampled. Maps of the spatial distribution of the emission lines and of the physical-chemical properties of the ionized ISM have been created and analysed. Here, we refine the statistical methodology by Pérez-Montero et al. (2011) to probe the presence of variations in the ISM properties. An error-weighted mean of 12+log(O/H) = 7.72 ± 0.01 is taken as the representative oxygen abundance for Mrk 178. A localized N and He enrichment, spatially correlated with WR stars, is suggested by this analysis. Nebular He II λ4686 emission is shown to be spatially extended reaching well beyond the location of the WR stars. This spatial offset between WRs and He II emission can be explained based on the mechanical energy input into the ISM by the WR star winds, and does not rule out WR stars as the He II ionization source. We study systematic aperture effects on the detection and measurement of the WR features, using Sloan Digital Sky Survey spectra combined with the power of IFS. In this regard, the importance of targeting low metallicity nearby systems is discussed.

Radioprotective Thiolamines WR-1065 and WR-33278 Selectively Denature Nonhistone Nuclear Proteins

NASA Technical Reports Server (NTRS)

Booth, Valerie K.; Roberts, Jeanette C.; Warters, Raymond L.; Wilmore, Britta H.; Lepock, James R.

2000-01-01

Differential scanning calorimetry was used to study the interactions of nuclei isolated from Chinese hamster V79 cells with the radioprotector WR-1065, other thiol compounds, and polyamines. Differential scanning calorimetry monitors denaturation of macromolecules and resolves the major nuclear components (e.g. constrained and relaxed DNA, nucleosome core, and nuclear matrix) of intact nuclei on the basis of thermal stability. WR-1065 treatment (0.5-10 mM) of isolated nuclei led to the irreversible denaturation of nuclear proteins, a fraction of which are nuclear matrix proteins. Denaturation of 50% of the total nonhistone nuclear protein content of isolated nuclei occurred after exposure to 4.7 mM WR-1065 for 20 min at 23 C. In addition, a 22% increase in the insoluble protein content of nuclei isolated from V79 cells that had been treated with 4 mM WR-1065 for 30 min at 37 C was observed, indicating that WR-1065-induced protein denaturation occurs not only in isolated nuclei but also in the nuclei of intact cells. From the extent of the increase in insoluble protein in the nucleus, protein denaturation by WR-1065 is expected to contribute to drug toxicity at concentrations greater than approximately 4 mM. WR-33278, the disulfide form of WR1065, was approximately twice as effective as the free thiol at denaturing nuclear proteins. The proposed mechanism for nucleoprotein denaturation is through direct interactions with protein cysteine groups with the formation of destabilizing protein-WR-1065 disulfides. In comparison to its effect on nuclear proteins in isolated nuclei, WR-1065 had only a very small effect on non-nuclear proteins of whole cells, isolated nuclear matrix, or the thiol-rich Ca (2+) ATPase of sarcoplasmic reticulum, indicating that WR-1065 can effectively denature protein only inside an intact nucleus, probably due to the increased concentration of the positively charged drug in the vicinity of DNA.

A new survey of nebulae around Galactic Wolf-Rayet stars in the northern sky

NASA Technical Reports Server (NTRS)

Miller, Grant J.; Chu, You-Hua

1993-01-01

Interference filter CCD images have been obtained in H-alpha and forbidden O III 5007 A for 62 Wolf-Rayet (W-R) stars, representing a complete survey of nebulae around Galactic W-R stars in the northern sky. We find probable new ring nebulae around W-R stars number 113, 116 and 132, and possible new ring nebulae around W-R stars number 133 and 153. All survey images showing nebulosities around W-R stars are presented in this paper. New physical information is derived from the improved images of known ring nebulae. The absence of ring nebulae around most W-R stars is discussed.

The X-ray monitoring of the long-period colliding wind binaries

NASA Astrophysics Data System (ADS)

Sugawara, Y.; Maeda, Y.; Tsuboi, Y.

2017-10-01

We present the first results from XMM-Newton and Swift observations of two long-period colliding wind binaries WR19 and WR125 around periastron passages. Mass-loss is one of the most important and uncertain parameters in the evolution of a massive star. The X-ray spectrum off the colliding wind binary is the best measure of conditions in the hot postshock gas. By monitoring the changing of the X-ray luminosity and column density along with the orbital phases, we derive the mass-loss rates of these stars. It is known that WR19 (WC5+O9; P=10.1 yr) and WR125 (WC7+O9; P> 24.3 yr) are the dust-making binaries. Each periastron is expected to come in 2016-2017. Since 2016, we carry out on-going monitoring campaigns of WR19 and WR125 with XMM-Newton and Swift. On these observations, the X-rays from WR19 and WR125 were detected for the first time. In the case of WR19, as periastron approached, the column density increased, which indicates that the emission from the wind-wind collision plasma was absorbed by the dense Wolf-Rayet wind.

2009: A Colliding-Wind Odyssey

NASA Astrophysics Data System (ADS)

Fahed, R.; Moffat, A. F. J.; Zorec, J.; Eversberg, T.; Chené, A. N.; Alves, F.; Arnold, W.; Bergmann, T.; Corcoran, M. F.; Correia Viegas, N. G.; Dougherty, S. M.; Fernando, A.; Frémat, Y.; Gouveia Carreira, L. F.; Hunger, T.; Knapen, J. H.; Leadbeater, R.; Marques Dias, F.; Martayan, C.; Morel, T.; Pittard, J. M.; Pollock, A. M. T.; Rauw, G.; Reinecke, N.; Ribeiro, J.; Romeo, N.; Sánchez-Gallego, J. R.; dos Santos, E. M.; Schanne, L.; Stahl, O.; Stober, Ba.; Stober, Be.; Vollmann, K.; Williams, P. M.

2012-12-01

We present the results from two optical spectroscopic campaigns on colliding-wind binaries (CWB) which both occurred in 2009. The first one was on WR 140 (WC7pd + O5.5fc), the archetype of CWB, which experienced periastron passage of its highly elliptical 8-year orbit in January. The WR 140 campaign consisted of a unique and constructive collaboration between amateur and professional astronomers and took place at half a dozen locations, including Teide Observatory, Observatoire de Haute Provence, Dominion Astrophysical Observatory, Observatoire du Mont-Mégantic and at several small private observatories. The second campaign was on a selection of 5 short-period WR + O binaries not yet studied for colliding-wind effects: WR 12 (WN8h), WR 21 (WN5o + O7 V), WR 30 (WC6 + O7.5 V), WR 31 (WN4o + O8), and WR 47 (WN6o + O5). The campaign took place at Leoncito Observatory, Argentina, during 1 month. We provide updated values of most of these systems for the orbital parameters, new estimates for the WR and O star masses and new constraints on the mass-loss rates and colliding wind geometry.

Analysis of heart rate and oxygen uptake kinetics studied by two different pseudo-random binary sequence work rate amplitudes.

PubMed

Drescher, U; Koschate, J; Schiffer, T; Schneider, S; Hoffmann, U

2017-06-01

The aim of the study was to compare the kinetics responses of heart rate (HR), pulmonary (V˙O 2 pulm) and predicted muscular (V˙O 2 musc) oxygen uptake between two different pseudo-random binary sequence (PRBS) work rate (WR) amplitudes both below anaerobic threshold. Eight healthy individuals performed two PRBS WR protocols implying changes between 30W and 80W and between 30W and 110W. HR and V˙O 2 pulm were measured beat-to-beat and breath-by-breath, respectively. V˙O 2 musc was estimated applying the approach of Hoffmann et al. (Eur J Appl Physiol 113: 1745-1754, 2013) considering a circulatory model for venous return and cross-correlation functions (CCF) for the kinetics analysis. HR and V˙O 2 musc kinetics seem to be independent of WR intensity (p>0.05). V˙O 2 pulm kinetics show prominent differences in the lag of the CCF maximum (39±9s; 31±4s; p<0.05). A mean difference of 14W between the PRBS WR amplitudes impacts venous return significantly, while HR and V˙O 2 musc kinetics remain unchanged. Copyright © 2017 Elsevier B.V. All rights reserved.

Complexation of tocotrienol with gamma-cyclodextrin enhances intestinal absorption of tocotrienol in rats.

PubMed

Ikeda, Saiko; Uchida, Tomono; Ichikawa, Tomio; Watanabe, Takashi; Uekaji, Yukiko; Nakata, Daisuke; Terao, Keiji; Yano, Tomohiro

2010-01-01

To determine the bioavailability of tocotrienol complex with gamma-cyclodextrin, the effects of tocotrienol/gamma-cyclodextrin complex on tocotrienol concentration in rat plasma and tissues were studied. Rats were administered by oral gavage an emulsion containing tocotrienol, tocotrienol with gamma-cyclodextrin, or tocotrienol/gamma-cyclodextrin complex. At 3 h after administration, the plasma gamma-tocotrienol concentration of the rats administered tocotrienol/gamma-cyclodextrin complex was higher than that of the rats administered tocotrienol and gamma-cyclodextrin. In order to determine the effect of complexation on tocotrienol absorption, rats were injected with Triton WR1339, which prevents the catabolism of triacylglycerol-rich lipoprotein by lipoprotein lipase, and then administered by oral gavage an emulsion containing tocotrienol, tocotrienol with gamma-cyclodextrin, or tocotrienol/gamma-cyclodextrin complex. The plasma gamma-tocotrienol concentration of the Triton-treated rats administered tocotrienol/gamma-cyclodextrin complex was higher than that of the other Triton-treated rats. These results suggest that complexation of tocotrienol with gamma-cyclodextrin elevates plasma and tissue tocotrienol concentrations by enhancing intestinal absorption.

Business Planning Model Programmer’s Guide

DTIC Science & Technology

1993-12-01

BPMREPI.PRG 847 temnpupgrade BPMOPEN.PRG 163 te - da -org BPMWHA2.PRG 1949 te tot BPMWHA2.PRG 1912 tgzzoggle BPMWHA2.PRG 349 tlbr UTILITY.PRG 921 toggle...closewindowIdispcapital get-totals disp capital. openwindow disp capital pad disp capital showeditinsg disp__capital tlbr disp capital wr-arr disp capital wr-dulsUdisp_...showeditnisg disp__contract tlbr disp contract wr -arrIdisp_ contract wr -duls disp contract wr uls disp__contract wrjyears disp expense closewindow

Massive stars: Their lives in the interstellar medium; Proceedings of the Symposium, ASP Annual Meeting, 104th, Univ. of Wisconsin, Madison, June 23-25, 1992

NASA Astrophysics Data System (ADS)

Cassinelli, Joseph P.; Churchwell, Edward B.

1993-01-01

Various papers on massive stars and their relationship to the interstellar medium are presented. Individual topics addressed include: observations of newly formed massive stars, star formation with nonthermal motions, embedded stellar clusters in H II regions, a Milky Way concordance, NH3 and H2O masers, PIGs in the Trapezium, star formation in photoevaporating molecular clouds, massive star evolution, mass loss from cool supergiant stars, massive runaway stars, CNO abundances in three A-supergiants, mass loss from late-type supergiants, OBN stars and blue supergiant supernovae, the most evolved W-R stars, X-ray variability in V444 Cygni, highly polarized stars in Cassiopeia, H I bubbles around O stars, interstellar H I LY-alpha absorption, shocked ionized gas in 30 Doradus, wind mass and energy deposition. Also discussed are: stellar wind bow shocks, O stars giant bubbles in M33, Eridanus soft X-ray enhancement, wind-blown bubbles in ejecta medium, nebulae around W-R stars, highly ionized gas in the LMC, cold ionized gas around hot H II regions, initial mass function in the outer Galaxy, late stages in SNR evolution, possible LBV in NGC 1313, old SN-pulsar association, cold bright matter near SN1987A, starbursts in the nearby universe, giant H II regions, powering the superwind in NGC 253, obscuration effects in starburst Galactic nuclei, starburst propagation in dwarf galaxies, 30 Doradus, W-R content of NGC 595 and NGC 604, Cubic Cosmic X-ray Background Experiment.

Extreme isolation of WN3/O3 stars and implications for their evolutionary origin as the elusive stripped binaries

NASA Astrophysics Data System (ADS)

Smith, Nathan; Götberg, Ylva; de Mink, Selma E.

2018-03-01

Recent surveys of the Magellanic Clouds have revealed a subtype of Wolf-Rayet (WR) star with peculiar properties. WN3/O3 spectra exhibit both WR-like emission and O3 V-like absorption - but at lower luminosity than O3 V or WN stars. We examine the projected spatial distribution of WN3/O3 stars in the Large Magellanic Cloud as compared to O-type stars. Surprisingly, WN3/O3 stars are among the most isolated of all classes of massive stars; they have a distribution similar to red supergiants dominated by initial masses of 10-15 M⊙, and are far more dispersed than classical WR stars or luminous blue variables. Their lack of association with clusters of O-type stars suggests strongly that WN3/O3 stars are not the descendants of single massive stars (30 M⊙ or above). Instead, they are likely products of interacting binaries at lower initial mass (10-18 M⊙). Comparison with binary models suggests a probable origin with primaries in this mass range that were stripped of their H envelopes through non-conservative mass transfer by a low-mass secondary. We show that model spectra and positions on the Hertzsprung-Russell diagram for binary-stripped stars are consistent with WN3/O3 stars. Monitoring radial velocities with high-resolution spectra can test for low-mass companions or runaway velocities. With lower initial mass and environments that avoid very massive stars, the WN3/O3 stars fit expectations for progenitors of Type Ib and possibly Type Ibn supernovae.

On Surface Losses in Direct Metal Laser Sintering Printed Millimeter and Submillimeter Waveguides

NASA Astrophysics Data System (ADS)

Holmberg, Max; Dancila, Dragos; Rydberg, Anders; Hjörvarsson, Björgvin; Jansson, Ulf; Marattukalam, Jithin James; Johansson, Niklas; Andersson, Joakim

2018-02-01

Different lengths of WR3 (220-330 GHz) and WR10 (75-110 GHz) waveguides are fabricated through direct metal laser sintering (DMLS). The losses in these waveguides are measured and modelled using the Huray surface roughness model. The losses in WR3 are around 0.3 dB/mm and in WR10 0.05 dB/mm. The Huray equation model is accounting relatively good for the attenuation in the WR10 waveguide but deviates more in the WR3 waveguide. The model is compared to finite element simulations of the losses assuming an approximate surface structure similar to the resulting one from the DMLS process.

On Surface Losses in Direct Metal Laser Sintering Printed Millimeter and Submillimeter Waveguides

NASA Astrophysics Data System (ADS)

Holmberg, Max; Dancila, Dragos; Rydberg, Anders; Hjörvarsson, Björgvin; Jansson, Ulf; Marattukalam, Jithin James; Johansson, Niklas; Andersson, Joakim

2018-06-01

Different lengths of WR3 (220-330 GHz) and WR10 (75-110 GHz) waveguides are fabricated through direct metal laser sintering (DMLS). The losses in these waveguides are measured and modelled using the Huray surface roughness model. The losses in WR3 are around 0.3 dB/mm and in WR10 0.05 dB/mm. The Huray equation model is accounting relatively good for the attenuation in the WR10 waveguide but deviates more in the WR3 waveguide. The model is compared to finite element simulations of the losses assuming an approximate surface structure similar to the resulting one from the DMLS process.

Importance of compensatory heart rate increase during myocardial ischemia to preserve appropriate oxygen kinetics.

PubMed

Yoshida, Sadamitsu; Adachi, Hitoshi; Murata, Makoto; Tomono, Junichi; Oshima, Shigeru; Kurabayashi, Masahiko

2017-09-01

Myocardial ischemia induces cardiac dysfunction, resulting in insufficient oxygen supply to peripheral tissues and mismatched energy production during exercise. To relieve the insufficient oxygen supply, heart rate (HR) response is augmented; however, beta-adrenergic receptor blockers (BB) restrict HR response. Although BB are essential drugs for angina pectoris, the effect of BB on exercise tolerance in patients with angina has not been studied. The aim of this study was to clarify the importance of HR augmentation to preserve exercise tolerance in patients with angina pectoris. Forty-two subjects who underwent cardiopulmonary exercise testing (CPX) to detect myocardial ischemia were enrolled. CPX was performed until exhaustion or onset of significant myocardial ischemia using a ramp protocol. Subjects were assigned to three groups (Group A: with ST depression during CPX with significant coronary stenosis and taking BB; Group B: with ST depression and not taking BB; Group C: without ST depression and not taking BB). HR response to exercise was evaluated during the following two periods: below and above ischemic threshold (IT). In Group C, it was evaluated during the first 2min and the last 2min of a ramp exercise. No significant differences were observed among the three groups with regard to patients' basic characteristics. Below IT, there were no differences in oxygen pulse/watt (O 2 pulse increasing rate), HR/watt (ΔHR/ΔWR), and ΔV˙O 2 /ΔWR. Above IT, O 2 pulse increasing rate was greater in Group A than in Group B. ΔHR/ΔWR was smaller in Group A than in Group B. ΔV˙O 2 /ΔWR became smaller in Group A than in Group B. There was no difference in anaerobic threshold, and peak V˙O 2 was smaller in Group A than in Group B. Restriction of HR response by a BB is shown to be one of the important factors in diminished exercise tolerance. Copyright © 2016 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.

Differential antimutagenicity of WR-1065 added after irradiation in L5178Y cell lines

NASA Technical Reports Server (NTRS)

Evans, H. H.; Horng, M. F.; Ricanati, M.; McCoy, E. C.

1999-01-01

The purpose of this study was to determine the antimutagenicity of WR-1065 added after irradiation of cells of cell lines differing in their ability to rejoin radiation-induced DNA double-strand breaks (DSBs). The postirradiation antimutagenicity of WR-1065 at the thymidine kinase locus was demonstrated for L5178Y (LY)-S1 cells that are deficient in repair of DNA DSBs. Less postirradiation antimutagenicity of WR-1065 was observed in LY-R16 and LY-SR1 cells, which are relatively efficient in DSB repair. Postirradiation treatment with WR-1065 had only a small stimulatory effect on DSB rejoining. A 3-h incubation of irradiated LY cells with WR-1065 caused slight changes in the distribution of cells in the phases of the cell cycle that differed between LY-S1 and LY-SR1 cells. Both LY-S1 and LY-SR1 cells were protected against the cytotoxic and mutagenic effects of radiation when WR-1065 was present 30 min before and during the irradiation. We conclude that the differential postirradiation effects of WR-1065 in the LY-S1 and LY-SR1 cells are not caused by differences in cellular uptake of the radioprotector or in its radical scavenging activity. Possible mechanisms for the postirradiation antimutagenicity of WR-1065 are discussed.

A search for ejecta nebulae around Wolf-Rayet stars using the SHS Hα survey

NASA Astrophysics Data System (ADS)

Stock, D. J.; Barlow, M. J.

2010-12-01

Recent large-scale Galactic plane Hα surveys allow a re-examination of the environs of Wolf-Rayet (WR) stars for the presence of a circumstellar nebula. Using the morphologies of WR nebulae known to be composed of stellar ejecta as a guide, we constructed ejecta nebula criteria similar to those of Chu and searched for likely WR ejecta nebulae in the Southern Hα Survey (SHS). A new WR ejecta nebula around WR 8 is found and its morphology is discussed. The fraction of WR stars with ejecta-type nebulae is roughly consistent between the Milky Way (MW) and Large Magellanic Cloud (LMC) at around 5-6 per cent, with the MW sample dominated by nitrogen-rich WR central stars (WN type) and the LMC stars having a higher proportion of carbon-rich WR central stars (WC type). We compare our results with those of previous surveys, including those of Marston and Miller & Chu, and find broad consistency. We investigate several trends in the sample: most of the clear examples of ejecta nebulae have WNh central stars, and very few ejecta nebulae have binary central stars. Finally, the possibly unique evolutionary status of the nebula around the binary star WR 71 is explored.

Infrared Photometric Study of Wolf–Rayet Galaxies

NASA Astrophysics Data System (ADS)

Chen, P. S.; Yang, X. H.; Liu, J. Y.; Shan, H. G.

2018-01-01

We collected observational data on 781 Wolf–Rayet (WR) galaxies from the literature to photometrically study their infrared properties measured by the 2MASS, WISE, IRAS, AKARI, and Herschel missions. It is found that in the 1–5 μm range the radiations of WR galaxies are dominated by the free–free emissions from the stellar winds and the circumstellar dust from the late-type stars in the host galaxy. In the 5–22 μm range, the radiation of WR galaxies is dominated by the free–free emissions and the synchrotron radiation from the central active galactic nucleus (AGN; but not always present). In the 22–140 μm range, the radiations of WR galaxies are dominated by the free–free emissions and the star formation/starburst activities. In the 250–500 μm range, the radiation of WR galaxies is dominated by the free–free emissions. In addition, the comparison with the non-WR galaxies is made. It is shown that some star formation WR galaxies have redder near-infrared colors than non-WR star-forming galaxies probably due to the gas emission in the near-infrared. In the 2–5 μm region WR galaxies have redder colors due to the thermal emission from circumstellar dust of late-type stars and the enhanced gas emission. In the 5–22 μm region, both WR galaxies and non-WR galaxies have similar behavior, indicative of having similar free–free emission as the dominant radiation. In the 25–140 μm region, both types of galaxies also have similar behavior, indicative of having free–free emission from the stellar winds or the thermal radiation from the starburst/star formation as the dominant radiation.

Wolf-Rayet stars in the Small Magellanic Cloud as testbed for massive star evolution

NASA Astrophysics Data System (ADS)

Schootemeijer, A.; Langer, N.

2018-03-01

Context. The majority of the Wolf-Rayet (WR) stars represent the stripped cores of evolved massive stars who lost most of their hydrogen envelope. Wind stripping in single stars is expected to be inefficient in producing WR stars in metal-poor environments such as the Small Magellanic Cloud (SMC). While binary interaction can also produce WR stars at low metallicity, it is puzzling that the fraction of WR binaries appears to be about 40%, independent of the metallicity. Aim. We aim to use the recently determined physical properties of the twelve known SMC WR stars to explore their possible formation channels through comparisons with stellar models. Methods: We used the MESA stellar evolution code to construct two grids of stellar models with SMC metallicity. One of these consists of models of rapidly rotating single stars, which evolve in part or completely chemically homogeneously. In a second grid, we analyzed core helium burning stellar models assuming constant hydrogen and helium gradients in their envelopes. Results: We find that chemically homogeneous evolution is not able to account for the majority of the WR stars in the SMC. However, in particular the apparently single WR star SMC AB12, and the double WR system SMC AB5 (HD 5980) appear consistent with this channel. We further find a dichotomy in the envelope hydrogen gradients required to explain the observed temperatures of the SMC WR stars. Shallow gradients are found for the WR stars with O star companions, while much steeper hydrogen gradients are required to understand the group of hot apparently single WR stars. Conclusions: The derived shallow hydrogen gradients in the WR component of the WR+O star binaries are consistent with predictions from binary models where mass transfer occurs early, in agreement with their binary properties. Since the hydrogen profiles in evolutionary models of massive stars become steeper with time after the main sequence, we conclude that most of the hot (Teff > 60 kK ) apparently single WR stars lost their envelope after a phase of strong expansion, e.g., as the result of common envelope evolution with a lower mass companion. The so far undetected companions, either main sequence stars or compact objects, are then expected to still be present. A corresponding search might identify the first immediate double black hole binary progenitor with masses as high as those detected in GW150914.

Photodynamic injury of isolated crayfish neuron and surrounding glial cells: the role of p53

NASA Astrophysics Data System (ADS)

Sharifulina, S. A.; Uzdensky, A. B.

2015-03-01

The pro-apoptotic transcription factor p53 is involved in cell responses to injurious impacts. Using its inhibitor pifithrin- α and activators tenovin-1, RITA and WR-1065, we studied its potential participation in inactivation and death of isolated crayfish mechanoreceptor neuron and satellite glial cells induced by photodynamic treatment, a strong inducer of oxidative stress. In dark, p53 activation by tenovin-1 or WR-1065 shortened activity of isolated neurons. Tenovin-1 and WR-1065 induced apoptosis of glial cells, whereas pifithrin-α was anti-apoptotic. Therefore, p53 mediated glial apoptosis and suppression of neuronal activity after axotomy. Tenovin-1 but not other p53 modulators induced necrosis of axotomized neurons and surrounding glia, possibly, through p53-independent pathway. Under photodynamic treatment, p53 activators tenovin-1 and RITA enhanced glial apoptosis indicating the pro-apoptotic activity of p53. Photoinduced necrosis of neurons and glia was suppressed by tenovin-1 and, paradoxically, by pifithrin-α. Modulation of photoinduced changes in the neuronal activity and necrosis of neurons and glia was possibly p53-independent. The different effects of p53 modulators on neuronal and glial responses to axotomy and photodynamic impact were apparently associated with different signaling pathways in neurons and glial cells.

Walk-Rally Support System Using Two-Dimensional Codes and Mobile Phones

ERIC Educational Resources Information Center

Miyagawa, Tetsuya; Yamagishi, Yoshio; Mizuno, Shun

2013-01-01

"Walk Rally" (WR), an orienteering-like recreation game, is common, especially in Japan. Numerous trials to combine WR with educational activities are being carried out by some educators. However, participants are always at the risk of straying and subjected to various accidents during the WR. We developed a WR support system based on…

Colliding winds in five WR+O systems of the Southern hemisphere

NASA Astrophysics Data System (ADS)

Fahed, R.; Moffat, A. F. J.

2012-08-01

We present the results of an optical spectroscopic follow-up of five WR+O systems of the Southern hemisphere that have not been studied so far for wind-wind collisions: WR 12 (WN8h), WR 21 (WN5o+O7V), WR 30 (WC6+O7.5V), WR 31 (WN4o+O8) and WR 47 (WN6o+O5). Observations were made over an entire contiguous month using the Garrison spectrograph attached to the 0.6-m Helen Sawyer Hogg telescope at Complejo Astronomico El Leoncito. We obtain improved orbital elements for these five systems and provide an estimation of the orbital inclination and shock-cone opening angle for four of them by analysing excess emission profiles with the geometrical model of Lührs. We argue that line variability in one of the stars (WR 12) might be dominated by some dynamic instabilities in the shocked plasma, making the model inappropriate in this case. A sixth star, WR 69 (WC9d+OB), was observed in the programme based on its published photometric period of 2.293 ± 0.005 d. While we found a probable spectroscopic period of 2.15 ± 0.04 d compatible with that of Marchenko et al. (1998), the period is unlikely related to orbital effects, rather to (relatively fast) rotation of the WC9d component of a much longer binary system.

Stabilization of glucocorticoid receptors in isolated rat hepatocytes by radioprotectants

DOE Office of Scientific and Technical Information (OSTI.GOV)

Karle, J.M.; Ridder, W.E.; Wright, N.

1986-05-01

Previous work has shown that glucocorticoid receptors in rat liver homogenate can be stabilized by the addition of MoO/sub 4/ plus the sulfhydryl-containing compounds dithiothreitol and WR 1065. The latter is the dephosphorylated, principal metabolite of the radioprotectant WR 2721 (or S-2-(3-aminopropylamino)ethanesphosphorothioic acid). The current work results from applying this knowledge to intact rat hepatocytes. Cells were isolated by collagenase perfusion and incubated in supplemented minimum essential medium at 37/sup 0/C with various concentrations of WR 2721, WR 1065, or vehicle. Samples of these cell suspensions were analyzed at various times for steroid binding capacity by incubating homogenates (27,000 xmore » g supernates) with 50 nM /sup 3/H-triamcinolone acetonide in the presence or absence of excess unlabelled dexamethasone. Concentrations of 10 mM WR 2721 provided marked preservation of the binding capacity (>85% of the initial value at 5 hours) compared to control at <20% by 2 hours. WR 2721 at 1 mM preserved >60% of the binding capacity. WR 1065 at 10 mM provided no such protection. This is consistent with the observation that WR 1065 does not pass cell membranes. The authors propose that supplying reducing equivalents to intracellular components such as the glucocorticoid receptor may be one mechanism of the radioprotection afforded by WR 2721.« less

8-Aminoquinolines from Walter Reed Army Institute for Research for treatment and prophylaxis of Pneumocystis pneumonia in rat models.

PubMed Central

Bartlett, M S; Queener, S F; Tidwell, R R; Milhous, W K; Berman, J D; Ellis, W Y; Smith, J W

1991-01-01

Three 8-aminoquinolines from the Walter Reed Army Institute for Research (WRAIR), WR6026, WR238605, and WR242511, strongly inhibited Pneumocystis carinii growth in vitro at 1 microgram/ml. This activity was similar to that of primaquine. In rat therapy models, the WRAIR compounds affected Pneumocystis pneumonia at doses as low as 0.25 mg/kg (WR242511) or 0.5 mg/kg (WR6026 and WR238605). At these doses, primaquine alone was ineffective as therapy. In a rat prophylaxis model, all three WRAIR 8-aminoquinolines were extremely effective at daily doses of 0.57 mg/kg, showing activity greater than that of primaquine at this dosage and comparable to that of trimethoprim-sulfamethoxazole at 50/250 mg/kg. PMID:2024961

LEW.1WR1 RATS DEVELOP AUTOIMMUNE DIABETES SPONTANEOUSLY AND IN RESPONSE TO ENVIRONMENTAL PERTURBATION

PubMed Central

Mordes, John P.; Leif, Jean H.; Woda, Bruce A.; Flanagan, Joan F.; Greiner, Dale L.; Kislauskis, Edward H.; Tirabassi, Rebecca S.

2005-01-01

We describe a new rat model of autoimmune diabetes that arose in a major histocompatibility complex (MHC) congenic LEW rat. Spontaneous diabetes in LEW.1WR1 rats (RT1u/u/a) occurs with a cumulative frequency of ∼2% at a median age of 59 days. The disease is characterized by hyperglycemia, glycosuria, ketonuria and polyuria. Both sexes are affected, and islets of acutely diabetic rats are devoid of beta cells whereas alpha and delta cell populations are spared. The peripheral lymphoid phenotype is normal, including the fraction of ART2+ regulatory T cells (Tregs). We tested the hypothesis that the expression of diabetes would be increased by immunological perturbation of innate or adaptive immunity. Treatment of young rats with depleting anti-ART2.1 mAb increased the frequency of diabetes to 50%. Treatment with the toll-like receptor 3 (TLR3) ligand polyinosinic:polycytidylic acid increased the frequency of diabetes to 100%. All diabetic rats exhibited end-stage islets. The LEW.1WR1 rat is also susceptible to collagen-induced arthritis but is free of spontaneous thyroiditis. The LEW.1WR1 rat provides a new model for studying autoimmune diabetes and arthritis in an animal with a genetic predisposition to both disorders that can be amplified by environmental perturbation. PMID:16123363

Long-range monostatic remote sensing of geomaterial structure weak vibrations

NASA Astrophysics Data System (ADS)

Heifetz, Alexander; Bakhtiari, Sasan; Gopalsami, Nachappa; Elmer, Thomas W.; Mukherjee, Souvik

2018-04-01

We study analytically and numerically signal sensitivity in remote sensing measurements of weak mechanical vibration of structures made of typical construction geomaterials, such as concrete. The analysis includes considerations of electromagnetic beam atmospheric absorption, reflection, scattering, diffraction and losses. Comparison is made between electromagnetic frequencies of 35GHz (Ka-band), 94GHz (W-band) and 260GHz (WR-3 waveguide band), corresponding to atmospheric transparency windows of the electromagnetic spectrum. Numerical simulations indicate that 94GHz frequency is optimal in terms of signal sensitivity and specificity for long-distance (>1.5km) sensing of weak multi-mode vibrations.

First survey of Wolf-Rayet star populations over the full extension of nearby galaxies observed with CALIFA

NASA Astrophysics Data System (ADS)

Miralles-Caballero, D.; Díaz, A. I.; López-Sánchez, Á. R.; Rosales-Ortega, F. F.; Monreal-Ibero, A.; Pérez-Montero, E.; Kehrig, C.; García-Benito, R.; Sánchez, S. F.; Walcher, C. J.; Galbany, L.; Iglesias-Páramo, J.; Vílchez, J. M.; González Delgado, R. M.; van de Ven, G.; Barrera-Ballesteros, J.; Lyubenova, M.; Meidt, S.; Falcon-Barroso, J.; Mast, D.; Mendoza, M. A.; Califa Collaboration

2016-08-01

The search of extragalactic regions with conspicuous presence of Wolf-Rayet (WR) stars outside the Local Group is challenging task owing to the difficulty in detecting their faint spectral features. In this exploratory work, we develop a methodology to perform an automated search of WR signatures through a pixel-by-pixel analysis of integral field spectroscopy (IFS) data belonging to the Calar Alto Legacy Integral Field Area survey, CALIFA. This procedure has been applied to a sample of nearby galaxies spanning a wide range of physical, morphological, and environmental properties. This technique allowed us to build the first catalogue of regions rich in WR stars with spatially resolved information, and enabled us to study the properties of these complexes in a two-dimensional (2D) context. The detection technique is based on the identification of the blue WR bump (around He IIλ4686 Å, mainly associated with nitrogen-rich WR stars; WN) and the red WR bump (around C ivλ5808 Å, mainly associated with carbon-rich WR stars; WC) using a pixel-by-pixel analysis that maximizes the number of independent regions within a given galaxy. We identified 44 WR-rich regions with blue bumps distributed in 25 out of a total of 558 galaxies. The red WR bump was identified only in 5 of those regions. Most of the WR regions are located within one effective radius from the galaxy centre, and around one-third are located within ~1 kpc or less from the centre. We found that the majority of the galaxies hosting WR populations in our sample are involved in some kind of interaction process. Half of the host galaxies share some properties with gamma-ray burst (GRB) hosts where WR stars, such as potential candidates to the progenitors of GRBs, are found. We also compared the WR properties derived from the CALIFA data with stellar population synthesis models, and confirm that simple star models are generally not able to reproduce the observations. We conclude that other effects, such as binary star channel (which could extend theWR phase up to 10 Myr), fast rotation, or other physical processes that cause the loss of observed Lyman continuum photons, very likely affect the derived WR properties, and hence should be considered when modelling the evolution of massive stars. Based on observations collected at the Centro Astronómico Hispano-Alemán (CAHA) at Calar Alto, operated jointly by the Max-Planck Institut für Astronomie and the Instituto de Astrofísica de Andalucía (CSIC).

Seafloor Tectonic Fault Fabric and the Evolution of the Walvis Ridge-Rio Grande Rise Hot Spot Twins in the South Atlantic

NASA Astrophysics Data System (ADS)

Sager, W. W.; Engfer, D.; Thoram, S.; Koppers, A. A. P.; Class, C.

2015-12-01

Walvis Ridge (WR) and Rio Grande Rise (RGR) are Cretaceous-Cenozoic large igneous provinces (LIPs) formed by the Tristan-Gough hot spot interacting with the Mid-Atlantic Ridge (MAR). Although hot spot-ridge interaction has long been considered a primary factor controlling WR-RGR morphology, details are fuzzy owing to sparse geophysical data. We examined tectonic fabric revealed in satellite altimetry-derived gravity data to infer details about RGR-WR evolution. Plate tectonic reconstructions indicate that the main RGR plateau and large N-S plateau in the eastern WR erupted at the same point at ~90 Ma. Over the next ~8 Myr, these conjunct LIPs formed a "V" shape with a basin in between. Curved fracture zones within the basin imply the two LIPs formed around a microplate. The prominent rift in the middle of RGR formed nearly perpendicular to the RGR-WR intersection, suggesting an extensional microplate boundary. Hot spot eruptions continued at the MAR, emplacing the eastern WR and two main RGR plateaus until ~60 Ma. During this period, the N-S trending Eastern Rio Grande Rise (ERGR) was erupted along the MAR. Both the ERGR and WR formed bathymetric lineaments parallel to seafloor fault fabric and were likely connected. This resulted in WR seamounts with a "tadpole" shape, the head being small to medium seamounts on the WR track and the tails being low, spreading-fabric-parallel ridges extending up to ~150 km northward. Similar, small seamounts are found in the contemporaneous ERGR. Another critical observation is that the WR-RGR formed at a large crustal discontinuity (~700 km at anomaly C33, ~84 Ma) at one or more fracture zone offsets. By late Cenozoic time (anomaly C5, ~10 Ma), the offset was reduced by half while several new fracture zones formed at the junction between RGR and WR. This implies a connection between ridge reorganization and RGR-WR volcanism that may have resulted from the fracture zones becoming oblique to the spreading direction as Euler poles for South America - Africa shifted. Finally, after ~60 Ma, volcanism emplaced seamounts mainly on the African plate and hot spot volcanism at the MAR was greatly reduced. Results from the present study augment recently published findings of a strong link between the formation of the RGR-WR LIP and spreading ridge tectonics.

A SYSTEMATIC SEARCH FOR COROTATING INTERACTION REGIONS IN APPARENTLY SINGLE GALACTIC WOLF-RAYET STARS. II. A GLOBAL VIEW OF THE WIND VARIABILITY

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chene, A.-N.; St-Louis, N., E-mail: achene@astro-udec.cl, E-mail: stlouis@astro.umontreal.ca

This study is the second part of a survey searching for large-scale spectroscopic variability in apparently single Wolf-Rayet (WR) stars. In a previous paper (Paper I), we described and characterized the spectroscopic variability level of 25 WR stars observable from the northern hemisphere and found 3 new candidates presenting large-scale wind variability, potentially originating from large-scale structures named corotating interaction regions (CIRs). In this second paper, we discuss an additional 39 stars observable from the southern hemisphere. For each star in our sample, we obtained 4-5 high-resolution spectra with a signal-to-noise ratio of {approx}100 and determined its variability level usingmore » the approach described in Paper I. In total, 10 new stars are found to show large-scale spectral variability of which 7 present CIR-type changes (WR 8, WR 44, WR55, WR 58, WR 61, WR 63, WR 100). Of the remaining stars, 20 were found to show small-amplitude changes and 9 were found to show no spectral variability as far as can be concluded from the data on hand. Also, we discuss the spectroscopic variability level of all single galactic WR stars that are brighter than v {approx} 12.5, and some WR stars with 12.5 < v {<=} 13.5, i.e., all the stars presented in our two papers and four more stars for which spectra have already been published in the literature. We find that 23/68 stars (33.8%) present large-scale variability, but only 12/54 stars ({approx}22.1%) are potentially of CIR type. Also, we find that 31/68 stars (45.6%) only show small-scale variability, most likely due to clumping in the wind. Finally, no spectral variability is detected based on the data on hand for 14/68 (20.6%) stars. Interestingly, the variability with the highest amplitude also has the widest mean velocity dispersion.« less

Wrist Circumference and Frame Size Percentiles in 6-17-Year-Old Turkish Children and Adolescents in Kayseri.

PubMed

Öztürk, Ahmet; Çiçek, Betül; Mazıcıoğlu, M Mümtaz; Zararsız, Gökmen; Kurtoğlu, Selim

2017-12-15

The aim of the current study was to provide wrist circumference (WrC) and body frame size (height/WrC) percentile values in Turkish children and adolescents aged 6-17 years. In this cross-sectional study, the data of "Determination of Anthropometric Measures of Turkish Children and Adolescents" (DAMTCA II) study in Kayseri/Turkey were used. A total of 4330 observations were recorded (1931 boys, 2399 girls). The WrC and frame size reference values were produced with generalized additive models for location, scale and shape. The WrC percentiles (3rd-97th) were calculated. The frame size (height/WrC) was estimated as small, medium, and large (<15 th , 15-85 th , and ≥85 th percentiles, respectively). For both genders, WrC linearly increased with age (13.0-16.8 cm for boys and 12.5-15.5 cm for girls). In boys and girls, the mean ± standard deviation of WrC is 13.00±0.89 cm and 12.48±0.93 cm (6 years) and increases to 16.83±1.16 and 15.58±0.86 cm (17 years), respectively. The WrC values in all age groups were higher in boys compared with girls. The increment in frame size from 6 to 17 years were 1.25 cm in boys and 0.85 cm in girls. WrC is a simple, easy-to-detect anthropometric index which is not subject to measurement errors. Additionally, WrC can be used both to decide about frame size and to determine metabolic risks related to obesity. We consider that this easy-to-get anthropometric index can be used both in screening procedures and clinical assessment procedure for obesity-related metabolic consequences.

Chronic wheel running reduces maladaptive patterns of methamphetamine intake: regulation by attenuation of methamphetamine-induced neuronal nitric oxide synthase.

PubMed

Engelmann, Alexander J; Aparicio, Mark B; Kim, Airee; Sobieraj, Jeffery C; Yuan, Clara J; Grant, Yanabel; Mandyam, Chitra D

2014-03-01

We investigated whether prior exposure to chronic wheel running (WR) alters maladaptive patterns of excessive and escalating methamphetamine intake under extended access conditions, and intravenous methamphetamine self-administration-induced neurotoxicity. Adult rats were given access to WR or no wheel (sedentary) in their home cage for 6 weeks. A set of WR rats were injected with 5-bromo-2'-deoxyuridine (BrdU) to determine WR-induced changes in proliferation (2-h old) and survival (28-day old) of hippocampal progenitors. Another set of WR rats were withdrawn (WRw) or continued (WRc) to have access to running wheels in their home cages during self-administration days. Following self-administration [6 h/day], rats were tested on the progressive ratio (PR) schedule. Following PR, BrdU was injected to determine levels of proliferating progenitors (2-h old). WRc rats self-administered significantly less methamphetamine than sedentary rats during acquisition and escalation sessions, and demonstrated reduced motivation for methamphetamine seeking. Methamphetamine reduced daily running activity of WRc rats compared with that of pre-methamphetamine days. WRw rats self-administered significantly more methamphetamine than sedentary rats during acquisition, an effect that was not observed during escalation and PR sessions. WR-induced beneficial effects on methamphetamine self-administration were not attributable to neuroplasticity effects in the hippocampus and medial prefrontal cortex, but were attributable to WR-induced inhibition of methamphetamine-induced increases in the number of neuronal nitric oxide synthase expressing neurons and apoptosis in the nucleus accumbens shell. Our results demonstrate that WR prevents methamphetamine-induced damage to forebrain neurons to provide a beneficial effect on drug-taking behavior. Importantly, WR-induced neuroprotective effects are transient and continued WR activity is necessary to prevent compulsive methamphetamine intake.

Chronic wheel running reduces maladaptive patterns of methamphetamine intake: regulation by attenuation of methamphetamine-induced neuronal nitric oxide synthase

PubMed Central

Engelmann, Alexander J.; Aparicio, Mark B.; Kim, Airee; Sobieraj, Jeffery C.; Yuan, Clara J.; Grant, Yanabel

2013-01-01

We investigated whether prior exposure to chronic wheel running (WR) alters maladaptive patterns of excessive and escalating methamphetamine intake under extended access conditions, and intravenous methamphetamine self-administration-induced neurotoxicity. Adult rats were given access to WR or no wheel (sedentary) in their home cage for 6 weeks. A set of WR rats were injected with 5-bromo-2′-deoxyuridine (BrdU) to determine WR-induced changes in proliferation (2-h old) and survival (28-day old) of hippocampal progenitors. Another set of WR rats were withdrawn (WRw) or continued (WRc) to have access to running wheels in their home cages during self-administration days. Following self-administration [6 h/day], rats were tested on the progressive ratio (PR) schedule. Following PR, BrdU was injected to determine levels of proliferating progenitors (2-h old). WRc rats self-administered significantly less methamphetamine than sedentary rats during acquisition and escalation sessions, and demonstrated reduced motivation for methamphetamine seeking. Methamphetamine reduced daily running activity of WRc rats compared with that of pre-methamphetamine days. WRw rats self-administered significantly more methamphetamine than sedentary rats during acquisition, an effect that was not observed during escalation and PR sessions. WR-induced beneficial effects on methamphetamine self-administration were not attributable to neuroplasticity effects in the hippocampus and medial prefrontal cortex, but were attributable to WR-induced inhibition of methamphetamine-induced increases in the number of neuronal nitric oxide synthase expressing neurons and apoptosis in the nucleus accumbens shell. Our results demonstrate that WR prevents methamphetamine-induced damage to forebrain neurons to provide a beneficial effect on drug-taking behavior. Importantly, WR-induced neuroprotective effects are transient and continued WR activity is necessary to prevent compulsive methamphetamine intake. PMID:23443965

Creating an enabling environment for WR&R implementation.

PubMed

Stathatou, P-M; Kampragou, E; Grigoropoulou, H; Assimacopoulos, D; Karavitis, C; Gironás, J

2017-09-01

Reclaimed water is receiving growing attention worldwide as an effective solution for alleviating the growing water scarcity in many areas. Despite the various benefits associated with reclaimed water, water recycling and reuse (WR&R) practices are not widely applied around the world. This is mostly due to complex and inadequate local legal and institutional frameworks and socio-economic structures, which pose barriers to wider WR&R implementation. An integrated approach is therefore needed while planning the implementation of WR&R schemes, considering all the potential barriers, and aiming to develop favourable conditions for enhancing reclaimed water use. This paper proposes a comprehensive methodology supporting the development of an enabling environment for WR&R implementation. The political, economic, social, technical, legal and institutional factors that may influence positively (drivers) or negatively (barriers) WR&R implementation in the regional water systems are identified, through the mapping of local stakeholder perceptions. The identified barriers are further analysed, following a Cross-Impact/System analysis, to recognize the most significant barriers inhibiting system transition, and to prioritize the enabling instruments and arrangements that are needed to boost WR&R implementation. The proposed methodology was applied in the Copiapó River Basin in Chile, which faces severe water scarcity. Through the analysis, it was observed that barriers outweigh drivers for the implementation of WR&R schemes in the Copiapó River Basin, while the key barriers which could be useful for policy formulation towards an enabling environment in the area concern the unclear legal framework regarding the ownership of treated wastewater, the lack of environmental policies focusing on pollution control, the limited integration of reclaimed water use in current land use and development policies, the limited public awareness on WR&R, and the limited availability of governmental funding sources for WR&R.

Location of WR stars in NGC 6744

NASA Astrophysics Data System (ADS)

Bibby, Joanne; Crowther, Paul; Sandford, Emily

2013-06-01

Following our recent survey of Wolf-Rayet (WR) stars in NGC 6744 we present a preliminary investigation into the location of these stars. Using high spatial resolution Hα images we find that the majority of WR stars are associated with nebular emission, albeit faint in many cases. We can use this HII association to constrain the lifetime and mass of the WR star since HII regions are such short-lived.

Chemotherapy of Rodent Malaria.

DTIC Science & Technology

1981-09-01

floxacrine analogue WR* (BK 02771) which remained fully effective against P.y.nigeriensis challenge seven days after treatment and was still partially...In particular we note that the Mannich base WR 194965 is highly active sc against the N strain and the moderately chloroquine resistant RC strain. The...this line. Floxacrine and the two floxacrine analogues WR* (BK02771) and WR* (BK 02780) have been compared and, whilst both analogues are markedj

Work-related mild-moderate traumatic brain injury and the construction industry.

PubMed

Liu, Margaret; Wei, Wenli; Fergenbaum, Jennifer; Comper, Paul; Colantonio, Angela

2011-01-01

Consequences of traumatic brain injury underscore the need to study high-risk groups. Few studies have investigated work-related traumatic brain injuries (WrTBIs) in the construction industry. To examine WrTBIs in Ontario for the construction industry compared to other industries. A retrospective study of individuals who sustained a WrTBI and had a clinical assessment as an outpatient at a hospital-based referral centre. Data were collected for a number of factors including demographic, injury and occupation and were analyzed according to the Person-Environment-Occupation (PEO) model. 435 individuals who sustained a WrTBI. There were 19.1% in the construction industry, 80.9% in other industries. Compared to other industries, individuals in the construction industry were more likely to be male, to not have attained post-secondary education, and experience multiple traumas. WrTBIs in the construction industry were commonly due to elevated work. The construction occupations involved included skilled workers and general labourers, and compared to other industries, WrTBIs occurred most often for those employed for a short duration in the construction industry. Construction industry workers experience serious WrTBIs that are amenable to prevention. Use of the PEO model increased our understanding of WrTBIs in the construction industry.

Soil recovery across a chronosequence of restored wetlands in the Florida Everglades

NASA Astrophysics Data System (ADS)

Wang, Qibing; Li, Yuncong; Zhang, Min

2015-12-01

The restoration project in the Hole-in-the-Donut of Everglades National Park in Florida, USA is to reestablish native wetlands by complete removal of the invasive plants and the associated soil. However, there is little information available about changes in properties of the newly formed Marl soils in restored wetlands. In this study, we measured soil physicochemical properties, soil enzymatic activities, and stable isotopes of carbon (δ13C) in plants and soil organic carbon (SOC) in an undisturbed natural wetland (UNW) and three wetlands restored respectively in 1989, 1996 and 1999 (WR89, WR96 and WR99). The older restored wetlands (WR89 and WR96) are characterized by greater SOC and mineral nitrogen. The values of soil dehydrogenase and phosphatase activities in the four wetlands follow the order: UNW > WR89 > WR96 > WR99, and are consistent with changes in vegetation coverage. The principal component analysis shows that dehydrogenase and phosphatase activities are the vital variables contributing to the soil of UNW. The similar δ13C values of SOC and plants in the restored wetlands suggest the formation of SOC during restoration is mainly derived from the associated plants. These results indicate that the newly restored soils develop toward the soil in the UNW with time since restoration.

Soil recovery across a chronosequence of restored wetlands in the Florida Everglades.

PubMed

Wang, Qibing; Li, Yuncong; Zhang, Min

2015-12-01

The restoration project in the Hole-in-the-Donut of Everglades National Park in Florida, USA is to reestablish native wetlands by complete removal of the invasive plants and the associated soil. However, there is little information available about changes in properties of the newly formed Marl soils in restored wetlands. In this study, we measured soil physicochemical properties, soil enzymatic activities, and stable isotopes of carbon (δ(13)C) in plants and soil organic carbon (SOC) in an undisturbed natural wetland (UNW) and three wetlands restored respectively in 1989, 1996 and 1999 (WR89, WR96 and WR99). The older restored wetlands (WR89 and WR96) are characterized by greater SOC and mineral nitrogen. The values of soil dehydrogenase and phosphatase activities in the four wetlands follow the order: UNW > WR89 > WR96 > WR99, and are consistent with changes in vegetation coverage. The principal component analysis shows that dehydrogenase and phosphatase activities are the vital variables contributing to the soil of UNW. The similar δ(13)C values of SOC and plants in the restored wetlands suggest the formation of SOC during restoration is mainly derived from the associated plants. These results indicate that the newly restored soils develop toward the soil in the UNW with time since restoration.

Oxygen uptake response to cycle ergometry in post-acute stroke patients with different severity of hemiparesis.

PubMed

Chen, Chun-Kai; Weng, Ming-Cheng; Chen, Tien-Wen; Huang, Mao-Hsiung

2013-11-01

This study evaluated the impact of severity of hemiparesis on oxygen uptake (VO2) response in post-acute stroke patients. Sixty-four patients with a mean poststroke interval of 8.6 ± 3.8 days underwent a ramp cardiopulmonary exercise test on a cycling ergometer to volitional termination. Mean peak VO2 (VO2peak) and work efficiency (ΔVO2/ΔWR) were measured by open-circuit spirometry during standard upright ergometer cycling. Severity of the hemiparetic lower limb was assessed by Brunnstrom's motor recovery stages lower extremity (BMRSL). VO2peak was 10% lower in hemiparetic leg with BMRSL V than in that with BMRSL VI, 20% lower in BMRSL IV, and 50% lower in BMRSL III. ΔVO2/ΔWR was higher for the group with increased BMRSL. The relations were consistent after adjustment for age, sex, body mass index, stroke type, hemiparetic side, modified Ashworth Scale, time poststroke, comorbidities, and medications. Our findings revealed that O2peak is dependent on the severity of hemiparesis in leg, and along with ΔO2/ΔWR closely related to the severity of hemiparesis in post-acute stroke patients, regardless of the types and locations of lesion after stroke, as well as the differences in comorbidities and medications. Copyright © 2013. Published by Elsevier B.V.

The first optical spectra of Wolf-Rayet stars in M101 revealed with Gemini/GMOS

NASA Astrophysics Data System (ADS)

Pledger, J. L.; Shara, M. M.; Wilde, M.; Crowther, P. A.; Long, K. S.; Zurek, D.; Moffat, A. F. J.

2018-01-01

Deep narrow-band Hubble Space Telescope (HST) imaging of the iconic spiral galaxy M101 has revealed over a thousand new Wolf-Rayet (WR) candidates. We report spectrographic confirmation of 10 He II-emission line sources hosting 15 WR stars. We find WR stars present at both sub- and super-solar metallicities with WC stars favouring more metal-rich regions compared to WN stars. We investigate the association of WR stars with H II regions using archival HST imaging and conclude that the majority of WR stars are in or associated with H II regions. Of the 10 emission lines sources, only one appears to be unassociated with a star-forming region. Our spectroscopic survey provides confidence that our narrow-band photometric candidates are in fact bona fide WR stars, which will allow us to characterize the progenitors of any core-collapse supernovae that erupt in the future in M101.

Searches for light sterile neutrinos with multitrack displaced vertices

NASA Astrophysics Data System (ADS)

Cottin, Giovanna; Helo, Juan Carlos; Hirsch, Martin

2018-03-01

We study discovery prospects for long-lived sterile neutrinos at the LHC with multitrack displaced vertices, with masses below the electroweak scale. We reinterpret current displaced vertex searches making use of publicly available, parametrized selection efficiencies for modeling the detector response to displaced vertices. We focus on the production of right-handed WR bosons and neutrinos N in a left-right symmetric model, and find poor sensitivity. After proposing a different trigger strategy (considering the prompt lepton accompanying the neutrino displaced vertex) and optimized cuts in the invariant mass and track multiplicity of the vertex, we find that the LHC with √{s }=13 TeV and 300 fb-1 is able to probe sterile neutrino masses between 10 GeV

WNL Stars - the Most Massive Stars in the Universe?

NASA Astrophysics Data System (ADS)

Schnurr, Olivier; Moffat, Anthony F. J.; St-Louis, Nicole; Skalkowski, Gwenael; Niemela, Virpi; Shara, Michael M.

2001-08-01

We propose to carry out an intensive and complete time-dependent spectroscopic study of all 47 known WNL stars in the LMC, an ideal laboratory to study the effect of lower ambient metallicity, Z, on stellar evolution. WNL stars are luminous, cooler WR stars of the nitrogen sequence. This will allow us to: 1) determine the binary frequency. The Roche-lobe overflow (RLOF) mechanism in close binaries is predicted to be responsible for the formation of a significant fraction of WR stars in low Z environments such as the LMC. 2) determine the masses. Since some of these stars (denoted WNL(h) or WNLh) are supposed to be hydrogen-burning and thus main-sequence stellar objects of the highest luminosity, they may be the most massive stars known. 3) study wind-wind collision (WWC) effects in WR+O binaries involving very luminous WNL stars with strong winds. Interesting in itself as a high-energy phenomenon, WWC is in competition with conservative RLOF (i.e. mass transfer to the secondary star), and therefore has to be taken into account in this context.

WNLh Stars - The Most Massive Stars in the Universe?

NASA Astrophysics Data System (ADS)

Schnurr, Olivier; St-Louis, Nicole; Moffat, Anthony F. J.; Foellmi, Cedric

2002-08-01

We propose to conclude our intensive and complete time-dependent spectroscopic study of all 47 known WNL stars in the LMC, an ideal laboratory to study the effect of lower ambient metallicity, Z, on stellar evolution. WNL stars are luminous, cooler WR stars of the nitrogen sequence. This will allow us to: 1) determine the binary frequency. The Roche-lobe overflow (RLOF) mechanism in close binaries is predicted to be responsible for the formation of a significant fraction of WR stars in low Z environments such as the LMC. 2) determine the masses. Since some of these stars (denoted WNL(h) or WNLh) are supposed to be hydrogen-burning and thus main-sequence stellar objects of the highest luminosity, they may be the most massive stars known. 3) study wind-wind collision (WWC) effects in WR+O binaries involving very luminous WNL stars with strong winds. Interesting in itself as a high-energy phenomenon, WWC is in competition with conservative RLOF (i.e. mass transfer to the secondary star), and therefore has to be taken into account in this context.

Large-scale Star-formation-driven Outflows at 1 < z < 2 in the 3D-HST Survey

NASA Astrophysics Data System (ADS)

Lundgren, Britt F.; Brammer, Gabriel; van Dokkum, Pieter; Bezanson, Rachel; Franx, Marijn; Fumagalli, Mattia; Momcheva, Ivelina; Nelson, Erica; Skelton, Rosalind E.; Wake, David; Whitaker, Katherine; da Cunha, Elizabete; Erb, Dawn K.; Fan, Xiaohui; Kriek, Mariska; Labbé, Ivo; Marchesini, Danilo; Patel, Shannon; Rix, Hans Walter; Schmidt, Kasper; van der Wel, Arjen

2012-11-01

We present evidence of large-scale outflows from three low-mass (log(M */M ⊙) ~ 9.75) star-forming (SFR > 4 M ⊙ yr-1) galaxies observed at z = 1.24, z = 1.35, and z = 1.75 in the 3D-HST Survey. Each of these galaxies is located within a projected physical distance of 60 kpc around the sight line to the quasar SDSS J123622.93+621526.6, which exhibits well-separated strong (W λ2796 r >~ 0.8 Å) Mg II absorption systems matching precisely to the redshifts of the three galaxies. We derive the star formation surface densities from the Hα emission in the WFC3 G141 grism observations for the galaxies and find that in each case the star formation surface density well exceeds 0.1 M ⊙ yr-1 kpc-2, the typical threshold for starburst galaxies in the local universe. From a small but complete parallel census of the 0.65 < z < 2.6 galaxies with H 140 <~ 24 proximate to the quasar sight line, we detect Mg II absorption associated with galaxies extending to physical distances of 130 kpc. We determine that the Wr > 0.8 Å Mg II covering fraction of star-forming galaxies at 1 < z < 2 may be as large as unity on scales extending to at least 60 kpc, providing early constraints on the typical extent of starburst-driven winds around galaxies at this redshift. Our observations additionally suggest that the azimuthal distribution of Wr > 0.4 Å Mg II absorbing gas around star-forming galaxies may evolve from z ~ 2 to the present, consistent with recent observations of an increasing collimation of star-formation-driven outflows with time from z ~ 3.

Blood values of adult captive cheetahs (Acinonyx jubatus) fed either supplemented beef or whole rabbit carcasses.

PubMed

Depauw, Sarah; Hesta, M; Whitehouse-Tedd, K; Stagegaard, J; Buyse, J; Janssens, G P J

2012-01-01

This study evaluated nutrient intake and relevant blood parameters of 14 captive cheetahs, randomly assigned to a meat-only diet (supplemented beef, SB) or a whole prey diet (whole rabbit, WR) for 4 weeks each. Despite a higher food intake, daily metabolizable energy intake was lower when fed WR (308 kJ BW(-1) ) compared with SB (347 kJ BW(-1) ) (P = 0.002). The ratio of protein to fat was markedly lower for WR (2.3:1) compared with SB (8.8:1), which was reflected in higher serum urea levels when fed SB (P = 0.033), and a tendency for elevated cholesterol levels when fed WR (P = 0.055). Taurine intake of cheetahs fed WR was low (0.06% on DM basis); however, analytical error during taurine analysis cannot be ruled out. Feeding WR resulted in a well-balanced mineral intake, in contrast to SB. The latter provided a low calcium:phosphorus ratio (1:2.3), thereby increasing the risk of metabolic bone disease. The high zinc content of SB (200 mg/kg DM), compared with WR (94 mg/kg DM), was reflected in higher serum zinc concentrations (P = 0.011). Feeding WR resulted in an increase in serum vitamin A (P = 0.011). Therefore, the risk of hypervitaminosis A in captive cheetahs when fed WR exclusively on a long-term basis should be evaluated. Our findings suggest that neither diet is likely to provide appropriate nutrition to captive cheetahs when fed exclusively. © 2011 Wiley Periodicals, Inc.

Plasmid partition system of the P1par family from the pWR100 virulence plasmid of Shigella flexneri.

PubMed

Sergueev, Kirill; Dabrazhynetskaya, Alena; Austin, Stuart

2005-05-01

P1par family members promote the active segregation of a variety of plasmids and plasmid prophages in gram-negative bacteria. Each has genes for ParA and ParB proteins, followed by a parS partition site. The large virulence plasmid pWR100 of Shigella flexneri contains a new P1par family member: pWR100par. Although typical parA and parB genes are present, the putative pWR100parS site is atypical in sequence and organization. However, pWR100parS promoted accurate plasmid partition in Escherichia coli when the pWR100 Par proteins were supplied. Unique BoxB hexamer motifs within parS define species specificities among previously described family members. Although substantially different from P1parS from the P1 plasmid prophage of E. coli, pWR100parS has the same BoxB sequence. As predicted, the species specificity of the two types proved identical. They also shared partition-mediated incompatibility, consistent with the proposed mechanistic link between incompatibility and species specificity. Among several informative sequence differences between pWR100parS and P1parS is the presence of a 21-bp insert at the center of the pWR100parS site. Deletion of this insert left much of the parS activity intact. Tolerance of central inserts with integral numbers of helical DNA turns reflects the critical topology of these sites, which are bent by binding the host IHF protein.

Properties of selected S-nitrosothiols compared to nitrosylated WR-1065.

PubMed

Whiteside, William Michael; Sears, Devin N; Young, Paul R; Rubin, David B

2002-05-01

WR-1065 ([N-mercaptoethyl]-1-3-diaminopropane), the active form of the aminothiol drug Ethyol/Amifostine, protects against toxicity caused by radiation, chemotherapy and endotoxin. Because WR-1065 and other thiols readily bind nitric oxide (NO), injurious conditions or therapies that induce the production or mobilization of NO could alter the effects of WR-1065. S-Nitrosothiols were prepared from various thiols by a standard method to compare properties and stability. Heteromolecular quantum correlation 2D nuclear magnetic resonance was used to characterize nitrosylated glutathione (GSH) and WR-1065; both S- and N-nitrosothiols were observed, depending on the experimental conditions. Three categories of S-nitrosothiol stability were observed: (1) highly stable, with t(1/2) > 8 h, N-acetyl-L-cysteine nitrosothiol (t(1/2) 15 h) > GSH nitrosothiol (t(1/2) 8 h); (2) intermediate stability, t(1/2) approximately 2 h, cysteamine nitrosothiol and WR-1065 nitrosothiol; and (3) low stability, t(1/2) < 1 h, cysteine nitrosothiol and Captopril nitrosothiol. Similar relative rates were observed for Hg(+2)-induced denitrosylation: WR-1065 reacted faster than GSH nitrosothiol, while GSH nitrosothiol reacted faster than N-acetyl-L-cysteine nitrosothiol. Mostly mediated by mixed-NPSH disulfide formation, the activity of the redox-sensitive cysteine protease, cathepsin H, was inhibited by the S-nitrosothiols, with WR-1065 nitrosothiol > cysteine nitrosothiol > N-acetyl-L-cysteine nitrosothiol and GSH nitrosothiol. These observations indicate that, relative to other nitrosylated non-protein thiols, the S-nitrosothiol of WR-1065 is an unstable non-protein S-nitrosothiols with a high reactive potential in the modification of protein thiols.

Large-scale Periodic Variability of the Wind of the Wolf-Rayet Star WR 1 (HD 4004)

NASA Astrophysics Data System (ADS)

Chené, A.-N.; St-Louis, N.

2010-06-01

We present the results of an intensive photometric and spectroscopic monitoring campaign of the WN4 Wolf-Rayet (WR) star WR 1 = HD 4004. Our broadband V photometry covering a timespan of 91 days shows variability with a period of P = 16.9+0.6 -0.3 days. The same period is also found in our spectral data. The light curve is non-sinusoidal with hints of a gradual change in its shape as a function of time. The photometric variations nevertheless remain coherent over several cycles and we estimate that the coherence timescale of the light curve is of the order of 60 days. The spectroscopy shows large-scale line-profile variability which can be interpreted as excess emission peaks moving from one side of the profile to the other on a timescale of several days. Although we cannot unequivocally exclude the unlikely possibility that WR 1 is a binary, we propose that the nature of the variability we have found strongly suggests that it is due to the presence in the wind of the WR star of large-scale structures, most likely corotating interaction regions (CIRs), which are predicted to arise in inherently unstable radiatively driven winds when they are perturbed at their base. We also suggest that variability observed in WR 6, WR 134, and WR 137 is of the same nature. Finally, assuming that the period of CIRs is related to the rotational period, we estimate the rotation rate of the four stars for which sufficient monitoring has been carried out, i.e., v rot = 6.5, 40, 70, and 275 km s-1 for WR 1, WR 6, WR 134, and WR 137, respectively. Based on observations obtained at the Canada-France-Hawaii Telescope (CFHT) which is operated by the National Research Council of Canada, the Institut National des Sciences de l'Univers of the Centre National de Recherche Scientifique of France, and the University of Hawaii. Also based on observations obtained at the Observatoire du Mont Mégantic with is operated by the Centre de Recherche en Astrophysique du Québec and the Observatoire de Haute-Provence which is operated by the Institut National des Sciences de l'Univers of the Centre National de la Recherche Scientifique of France.

A deep survey for Galactic Wolf-Rayet stars. I - Motivation, search technique, and first results

NASA Technical Reports Server (NTRS)

Shara, Michael M.; Smith, Lindsey F.; Potter, Michael; Moffat, Anthony F. J.

1991-01-01

Results are presented from a survey of large areas of the southern Milky Way for Wolf-Rayet (WR) stars to 17-18th magnitude, carried out using direct narrowband and broadband Schmidt plates. Thirteen new WR stars were detected in an about 40-deg-sq region in Carina, where 24 WR stars were already known; the new stars were found to be significantly redder, fainter, and farther away than the known stars. Of the new WR stars, 11 are of subtype WN, and two are WC, compared to the 17 WN and seven WC stars among the previously known WR stars in the same area.

A comparison of data sources for the surveillance of work-related carpal tunnel syndrome in Massachusetts.

PubMed

Davis, Letitia; Wellman, Helen; Hart, James; Cleary, Robert; Gardstein, Betsey M; Sciuchetti, Paul

2004-09-01

This study examined whether a state surveillance system for work-related carpal tunnel syndrome (WR-CTS) based on workers' compensation claims (Sentinel Event Notification System for Occupational Risks, SENSOR) and the Annual Survey of Occupational Injuries and Illnesses (SOII) identified the same industries, occupations, sources of injury, and populations for intervention. Trends in counts, rates, and female/male ratios of WR-CTS during 1994-1997, and age distributions were compared across three data sources: SENSOR, Massachusetts SOII, and National SOII. SENSOR and National SOII data on WR-CTS were compared by industry, occupation, and injury source. Due to small sample size and subsequent gaps in available information, state SOII data on WR-CTS were of little use in identifying specific industries and occupations for intervention. SENSOR and National SOII data on the frequency of WR-CTS cases identified many similar occupations and industries, and both surveillance systems pointed to computer use as a risk factor for WR-CTS. Some high rate industries identified by SENSOR were not identified using National SOII rates even when national findings were restricted to take into account the distribution of the Massachusetts workforce. Use of national SOII data on rates of WR-CTS for identifying state industry priorities for WR-CTS prevention should be undertaken with caution. Options for improving state SOII data and use of other state data systems should be pursued.

Wolf-Rayet spin at low metallicity and its implication for black hole formation channels

NASA Astrophysics Data System (ADS)

Vink, Jorick S.; Harries, Tim J.

2017-07-01

Context. The spin of Wolf-Rayet (WR) stars at low metallicity (Z) is most relevant for our understanding of gravitational wave sources, such as GW 150914, and of the incidence of long-duration gamma-ray bursts (GRBs). Two scenarios have been suggested for both phenomena: one of them involves rapid rotation and quasi-chemical homogeneous evolution (CHE) and the other invokes classical evolution through mass loss in single and binary systems. Aims: The stellar spin of WR stars might enable us to test these two scenarios. In order to obtain empirical constraints on black hole progenitor spin we infer wind asymmetries in all 12 known WR stars in the Small Magellanic Cloud (SMC) at Z = 1 / 5 Z⊙ and within a significantly enlarged sample of single and binary WR stars in the Large Magellanic Cloud (LMC at Z = 1 / 2 Z⊙), thereby tripling the sample of Vink from 2007. This brings the total LMC sample to 39, making it appropriate for comparison to the Galactic sample. Methods: We measured WR wind asymmetries with VLT-FORS linear spectropolarimetry, a tool that is uniquely poised to perform such tasks in extragalactic environments. Results: We report the detection of new line effects in the LMC WN star BAT99-43 and the WC star BAT99-70, along with the well-known WR LBV HD 5980 in the SMC, which might be undergoing a chemically homogeneous evolution. With the previous reported line effects in the late-type WNL (Ofpe/WN9) objects BAT99-22 and BAT99-33, this brings the total LMC WR sample to four, I.e. a frequency of 10%. Perhaps surprisingly, the incidence of line effects amongst low Z WR stars is not found to be any higher than amongst the Galactic WR sample, challenging the rotationally induced CHE model. Conclusions: As WR mass loss is likely Z-dependent, our Magellanic Cloud line-effect WR stars may maintain their surface rotation and fulfill the basic conditions for producing long GRBs, both via the classical post-red supergiant or luminous blue variable channel, or resulting from CHE due to physics specific to very massive stars.

Association of Commercial Rice Varieties with Weedy Rice Accessions (Oryza sativa complex) in Pulau Pinang's Rice Granary Area.

PubMed

Hussain, Zainudin; Man, Azmi; Othman, Ahmad Sofiman

2011-12-01

Weedy rice (WR) is the most significant weed in direct-seeded fields. It has morphological characteristics similar to those of cultivated rice varieties. WR is more difficult to control than other weeds. We collected WR accessions from four sites within the Pulau Pinang rice growing areas. Thirty six different accessions were collected from each site: B, the northern site; P, the central site; A, the southern site; and N, the southwestern site. Wild rice (Oryza rufipogon), which grows in the sampled areas, was also collected together with four varieties (MR84, MR185, MR211 and MR219) that have been widely planted in these areas for a long period of time. The objective of this study was to compare the morphological characteristics of the WR accessions and cultivated rice. Twenty characteristics were observed for the comparison of WR accessions and rice cultivars. Morpho-matrix analyses allowed the specimens to be grouped to two main groups (A and B), based on a 95% dissimilarity matrix. Group A was subdivided into 7 subgroups consisting of a few WR accessions, wild rice and MR211 (control), and group B was subdivided to 10 subgroups consisting of other WR accessions and the 3 other control varieties. Dendrogram analysis indicated that the morphological traits used in this study were able to differentiate among the WR accessions and the cultivars, except for rice cultivar MR211 and WRA8, which grouped together in subgroup A2. STRUCTURE program analysis indicated that all individuals were distinguishable and were divided into 18 clusters. These results suggest that some genes of the WR accessions have been influenced by commercial varieties. The information gained from this study will be useful to develop rice weed management protocols and good agricultural practices to control WR in the future.

Determination/Validation of Technologies for Treatment/Recycle of Contaminated Sludges: Phase 1 - Site/Sludge Characterization and Laboratory Testing

DTIC Science & Technology

1998-08-01

b. WR-ALC IWTP Plant #2 ........................... 35 2. Analysis of WR-ALC IWTP Streams and Sludges ................. 36 a. RCRA Metal Removal at WR...ECONOMIC ANALYSIS OF MOS-LLX AND USE OF A STOICHIO- METRIC AMOUNT OF FERROUS SULFATE FOR CrvI REDUCTION AT IWTP PLANT #2 AT WR-ALC...per day ICP or ICAP Inductively coupled Argon Plasma Elemental Analysis Technique IWTP Industrial Waste Water Treatment Plant LIX Liquid Ion Exchange

POPULATION I WOLF-RAYET RUNAWAY STARS: THE CASE OF WR124 AND ITS EXPANDING NEBULA M1-67

DOE Office of Scientific and Technical Information (OSTI.GOV)

Marchenko, S. V.; Moffat, A. F. J.; Crowther, P. A., E-mail: sergey.marchenko@ssaihq.co, E-mail: moffat@astro.umontreal.c, E-mail: Paul.Crowther@sheffield.ac.u

2010-11-20

In 1997 and 2008 we used the WFPC2 camera on board the Hubble Space Telescope to obtain two sets of narrow-band H{alpha} images of the runaway Wolf-Rayet (WR) star WR 124 surrounded by its nebula M1-67. This two-epoch imaging provides an expansion parallax and thus a practically assumption-free geometric distance to the nebula, d = 3.35 {+-} 0.67 kpc. Combined with the global velocity distribution in the ejected nebula, this confirms the extreme runaway status of WR 124. WR stars embedded within such ejection nebulae at the point of core collapse would produce different supernova characteristics from those expected formore » stars surrounded by wind-filled cavities. In galaxies with extremely low ambient metallicity, Z {<=} 10{sup -3} Z {sub sun}, {gamma}-ray bursts originating from fast-moving runaway WR stars may produce afterglows which appear to be coming from regions with a relatively homogeneous circumburst medium.« less

A Hubble Space Telescope planetary camera view of giant H II regions - The Wolf-Rayet content of NGC 595 and NGC 604 in M33

NASA Technical Reports Server (NTRS)

Drissen, Laurent; Moffat, Anthony F. J.; Shara, Michael M.

1993-01-01

We present images of NGC 595 and NGC 604, the most massive giant H II regions in M33, obtained with the Planetary Camera aboard the HST in order to study their WR population. Fourteen WR and/or Of candidates are detected in NGC 604, and eleven in NGC 595. All previously claimed 'superluminous' WR stars are found to be tight (diameter less than 3 pc) stellar aggregates containing one (or sometimes more) normal WR star. As suspected from ground-based data, the WR/O number ratio is significantly higher in NGC 595 (about 0.3) than in NGC 604 (about 0.1). The WR stars may be major contributors to the output of mechanical power and energy into the interstellar medium in both clusters. Over the observable initial mass range, the initial mass functions (IMFs) have similar slopes. These IMFs are somewhat flatter than those generally derived for massive stars in the Galaxy or the Magellanic Clouds.

Simultaneous Introduction of a Novel High Fat Diet and Wheel Running Induces Anorexia

PubMed Central

Scarpace, E. T.; Matheny, M.; Strehler, K. Y. E.; Shapiro, A.; Cheng, K. Y.; Tümer, N.; Scarpace, P. J.

2011-01-01

Voluntary wheel running (WR) is a form of physical activity in rodents that influences ingestive behavior. The present report describes an anorexic behavior triggered by the simultaneous introduction of a novel diet and WR. This study examined the sequential, compared with the simultaneous, introduction of a novel high-fat (HF) diet and voluntary WR in rats of three different ages and revealed a surprising finding; the simultaneous introduction of HF food and voluntary WR induced a behavior in which the animals chose not to eat although food was available at all times. This phenomenon was apparently not due to an aversion to the novel HF diet because introduction of the running wheels plus the HF diet, while continuing the availability of the normal chow diet did not prevent the anorexia. Moreover, the anorexia was prevented with prior exposure to the HF diet. In addition, the anorexia was not related to extent of WR but dependent on the act of WR. The introduction a HF diet and locked running wheels did not induce the anorexia. This voluntary anorexia was accompanied by substantial weight loss, and the anorexia was rapidly reversed by removal of the running wheels. Moreover, the HF/WR-induced anorexia is preserved across the age span despite the intrinsic decrease in WR activity and increased consumption of HF food with advancing age. The described phenomenon provides a new model to investigate anorexia behavior in rodents. PMID:22115947

Bearing the brunt: co-workers' experiences of work reintegration processes.

PubMed

Dunstan, Debra A; MacEachen, Ellen

2013-03-01

Work disability research has found co-worker support to be a significant but under-recognised aspect of work reintegration (WR) processes. Although co-workers work alongside returning workers, their practical contribution to WR success or failure is often invisible to others. This study aimed to gain further insight into the role and contribution of co-workers in WR interventions. An exploratory qualitative pilot study was conducted in Toronto, Canada in 2011. Three focus groups were conducted with 13 co-workers, recruited for their direct experience of 'working alongside' a returning worker. An iterative data gathering and analysis process occurred. Themes were generated from categories in open-ended interview questions and new issues arising from the data. The findings detail co-workers' practical experiences of WR processes and their reflections on social and work conditions that impacted their participation. Co-workers' capacity to support returning workers was related to the quality of the WR arrangements, the relationship with the returning worker, work culture, and the duration of the required support. Workplace privacy and confidentiality requirements were identified as a key challenge for co-worker participation. The effects on co-workers of WR processes ranged from the opportunity to learn new skills to disillusionment and withdrawal from the workplace. In worst case scenarios, 'ripple effects' including emotional distress, physical injury and termination of co-workers' employment had occurred. Co-workers are not a neutral party in WR procedures. Formalizing the co-worker role to include communication, consideration and recognition might improve co-workers' WR experiences.

The act of voluntary wheel running reverses dietary hyperphagia and increases leptin signaling in ventral tegmental area of aged obese rats.

PubMed

Shapiro, Alexandra; Cheng, Kit-Yan; Gao, Yongxin; Seo, Dong-Oh; Anton, Steve; Carter, Christy S; Zhang, Yi; Tumer, Nihal; Scarpace, Philip J

2011-01-01

To test the hypothesis that exercise increases central leptin signaling, and thus reduces dietary weight gain in an aged obese model, we assessed the effects of voluntary wheel running (WR) in 23-month-old F344×BN rats fed a 60% high-fat (HF) diet for 3 months. After 2 months on the HF diet, half of the rats were provided access to running wheels for 2 weeks while the other half remained sedentary. Following the removal of the wheels, physical performance was evaluated, and 4 weeks later leptin signaling was assessed in hypothalamus and VTA after an acute bout of WR. Introduction of a HF diet led to prolonged hyperphagia (63.9 ± 7.8 kcal/day on chow diet vs. 88.1 ± 8.2 kcal/day on high-fat diet (when food intake stabilized), p < 0.001). As little as 9 (ranging to 135) wheel revolutions per day significantly reduced caloric consumption of HF food (46.8 ± 11.2 kcal/day) to a level below that on chow diet (63.9 ± 7.8 kcal/day, p < 0.001). After 2 weeks of WR, body weight was significantly reduced (7.9 ± 2.1% compared with prerunning weight, p < 0.001), and physical performance (latency to fall from an incline plane) was significantly improved (p = 0.04). WR significantly increased both basal (p = 0.04) and leptin-stimulated (p = 0.001) STAT3 phosphorylation in the ventral tegmental area (VTA), but not in the hypothalamus. Thus, in aged dietary obese rats, the act but not the extent of voluntary WR is highly effective in reversing HF consumption, decreasing body weight, and improving physical performance. It appears to trigger a response that substitutes for the reward of highly palatable food that may be mediated by increased leptin signaling in the VTA. Copyright © 2010 S. Karger AG, Basel.

Cardiac function is preserved following 4 weeks of voluntary wheel running in a rodent model of chronic kidney disease.

PubMed

Kuczmarski, James M; Martens, Christopher R; Kim, Jahyun; Lennon-Edwards, Shannon L; Edwards, David G

2014-09-01

The purpose of this investigation was to determine the effect of 4 wk of voluntary wheel running on cardiac performance in the 5/6 ablation-infarction (AI) rat model of chronic kidney disease (CKD). We hypothesized that voluntary wheel running would be effective in preserving cardiac function in AI. Male Sprague-Dawley rats were divided into three study groups: 1) sham, sedentary nondiseased control; 2) AI-SED, sedentary AI; and 3) AI-WR, wheel-running AI. Animals were maintained over a total period of 8 wk following AI and sham surgery. The 8-wk period included 4 wk of disease development followed by a 4-wk voluntary wheel-running intervention/sedentary control period. Cardiac performance was assessed using an isolated working heart preparation. Left ventricular (LV) tissue was used for biochemical tissue analysis. In addition, soleus muscle citrate synthase activity was measured. AI-WR rats performed a low volume of exercise, running an average of 13 ± 2 km, which resulted in citrate synthase activity not different from that in sham animals. Isolated AI-SED hearts demonstrated impaired cardiac performance at baseline and in response to preload/afterload manipulations. Conversely, cardiac function was preserved in AI-WR vs. sham hearts. LV nitrite + nitrate and expression of LV nitric oxide (NO) synthase isoforms 2 and 3 in AI-WR were not different from those of sham rats. In addition, LV H2O2 in AI-WR was similar to that of sham and associated with increased expression of LV superoxide-dismutase-2 and glutathione peroxidase-1/2. The findings of the current study suggest that a low-volume exercise intervention is sufficient to maintain cardiac performance in rats with CKD, potentially through a mechanism related to improved redox homeostasis and increased NO. Copyright © 2014 the American Physiological Society.

The Wolf-Rayet star population in the dwarf galaxy NGC 625

NASA Astrophysics Data System (ADS)

Monreal-Ibero, A.; Walsh, J. R.; Iglesias-Páramo, J.; Sandin, C.; Relaño, M.; Pérez-Montero, E.; Vílchez, J.

2017-07-01

Context. Quantifying the number, type, and distribution of Wolf-Rayet (W-R) stars is a key component in the context of galaxy evolution, since they put constraints on the age of the star formation bursts. Nearby galaxies (distances ≲5 Mpc) are particularly relevant in this context since they fill the gap between studies in the Local Group, where individual stars can be resolved, and galaxies in the Local Volume and beyond. Aims: We intend to characterise the W-R star population in one of these systems, NGC 625, which is a low-metallicity dwarf galaxy suffering a currently declining burst of star formation. Methods: Optical integral field spectroscopy (IFS) data have been obtained with the VIMOS-IFU and the HR_Orange and HR_Blue gratings at the Very Large Telescope covering the starburst region of NGC 625. Ancillary Hubble Space Telescope (HST) images in the F555W and F814W bands are also used for comparison. We estimate the number of W-R stars using a linear combination of three W-R templates: one early-type nitrogen (WN) star, one late-type WN star, and one carbon-type (WC) star (or oxygen-type (WO) star). Fits using several ensembles of templates were tested. Results were confronted with I) high spatial resolution HST photometry; II) numbers of W-R stars in nearby galaxies; and III) model predictions. Results: The W-R star population is spread over the main body of the galaxy and is not necessarily coincident with the overall stellar distribution. Our best estimation for the number of W-R stars yields a total of 28 W-R stars in the galaxy, out of which 17 are early-type WN, six are late-type WN, and five are WC stars. The width of the stellar features nicely correlates with the dominant W-R type found in each aperture. The distribution of the different types of WR in the galaxy is roughly compatible with the way star formation has propagated in the galaxy, according to previous findings using high spatial resolution with the HST. Fits using templates at the metallicity of the Large Magellanic Cloud yield more reasonable number of W-R than those using templates at the metallicity of the Small Magellanic Cloud. Given the metallicity of NGC 625, this suggests a non-linear relation between the metallicity and luminosity of the W-R spectral features.

Evolutionary pattern of improved 1-mile running performance.

PubMed

Foster, Carl; de Koning, Jos J; Thiel, Christian

2014-07-01

The official world records (WR) for the 1-mile run for men (3:43.13) and for women (4:12.58) have improved 12.2% and 32.3%, respectively, since the first WR recognized by the International Association of Athletics Federations. Previous observations have suggested that the pacing pattern for successive laps is characteristically faster-slower-slowest-faster. However, modeling studies have suggested that uneven energy-output distribution, particularly a high velocity at the end of the race, is essentially wasted kinetic energy that could have been used to finish sooner. Here the authors report that further analysis of the pacing pattern in 32 men's WR races is characterized by a progressive reduction in the within-lap variation of pace, suggesting that improving the WR in the 1-mile run is as much about how energetic resources are managed as about the capacity of the athletes performing the race. In the women's WR races, the pattern of lap times has changed little, probably secondary to a lack of depth in the women's fields. Contemporary WR performances have been achieved a coefficient of variation of lap times on the order of 1.5-3.0%. Reasonable projection suggests that the WR is overdue for improving and may require lap times with a coefficient of variation of ~1%.

Return-to-work challenges following a work-related mild TBI: The injured worker perspective.

PubMed

Mansfield, Elizabeth; Stergiou-Kita, Mary; Cassidy, John David; Bayley, Mark; Mantis, Steve; Kristman, Vicki; Kirsh, Bonnie; Gomez, Manuel; Jeschke, Mark G; Vartanian, Oshin; Moody, Joel; Colantonio, Angela

2015-01-01

To explore how individuals with work-related mild traumatic brain injury (wrMTBI) experience return-to-work (RTW) processes when returning to the workplace where the injury occurred. RTW experiences were explored using in-depth interviews and an inductive analytic approach. Qualitative analysis guided by the research question moved through phases of line-by-line and thematic coding through which categories and the interaction between categories emerged. Twelve workers diagnosed with a wrMTBI reported on their RTW experiences following wrMTBIs that occurred 3-5 years prior to the time of the interview. Participants perceived employer and workers' compensation factors as profoundly influencing their RTW experiences. Participants consistently reported that employers and workers' compensation representatives had an inadequate understanding of wrMTBI sequelae. Six of 12 participants were re-injured following their wrMTBI, with three of these injuries occurring at work. Employers, co-workers and workers' compensation representatives should be aware of wrMTBI sequelae so injured workers can receive appropriate supports and both stigmatization and re-injury can be mitigated. Greater attention to the structural and social elements of workplace and compensation environments could inform strategies to break down barriers to successful return-to-work following a wrMTBI.

Return-to-work challenges following a work-related mild TBI: The injured worker perspective.

PubMed

Mansfield, Elizabeth; Stergiou-Kita, Mary; Cassidy, John David; Bayley, Mark; Mantis, Steve; Kristman, Vicki; Kirsh, Bonnie; Gomez, Manuel; Jeschke, Mark G; Vartanian, Oshin; Moody, Joel; Colantonio, Angela

2015-08-07

To explore how individuals with work-related mild traumatic brain injury (wrMTBI) experience return-to-work (RTW) processes when returning to the workplace where the injury occurred. RTW experiences were explored using in-depth interviews and an inductive analytic approach. Qualitative analysis guided by the research question moved through phases of line-by-line and thematic coding through which categories and the interaction between categories emerged. Twelve workers diagnosed with a wrMTBI reported on their RTW experiences following wrMTBIs that occurred 3-5 years prior to the time of the interview. Participants perceived employer and workers' compensation factors as profoundly influencing their RTW experiences. Participants consistently reported that employers and workers' compensation representatives had an inadequate understanding of wrMTBI sequelae. Six of 12 participants were re-injured following their wrMTBI, with three of these injuries occurring at work. Employers, co-workers and workers' compensation representatives should be aware of wrMTBI sequelae so injured workers can receive appropriate supports and both stigmatization and re-injury can be mitigated. Greater attention to the structural and social elements of workplace and compensation environments could inform strategies to break down barriers to successful return-to-work following a wrMTBI.

Discovery of a new Wolf-Rayet star and its ring nebula in Cygnus

NASA Astrophysics Data System (ADS)

Gvaramadze, V. V.; Fabrika, S.; Hamann, W.-R.; Sholukhova, O.; Valeev, A. F.; Goranskij, V. P.; Cherepashchuk, A. M.; Bomans, D. J.; Oskinova, L. M.

2009-11-01

We report the serendipitous discovery of a ring nebula around a candidate Wolf-Rayet (WR) star, HBHA4202-22, in Cygnus using the Spitzer Space Telescope archival data. Our spectroscopic follow-up observations confirmed the WR nature of this star (we named it WR138a) and showed that it belongs to the WN8-9h subtype. We thereby add a new example to the known sample of late WN stars with circumstellar nebulae. We analysed the spectrum of WR138a by using the Potsdam Wolf-Rayet (PoWR) model atmospheres, obtaining a stellar temperature of 40kK. The stellar wind composition is dominated by helium with 20 per cent of hydrogen. The stellar spectrum is highly reddened and absorbed (EB- V = 2.4mag, AV = 7.4mag). Adopting a stellar luminosity of logL/Lsolar = 5.3, the star has a mass-loss rate of 10-4.7Msolaryr-1, and resides in a distance of 4.2 kpc. We measured the proper motion for WR138a and found that it is a runaway star with a peculiar velocity of ~=50kms-1. Implications of the runaway nature of WR138a for constraining the mass of its progenitor star and understanding the origin of its ring nebula are discussed.

Different types of exercise induce differential effects on neuronal adaptations and memory performance.

PubMed

Lin, Tzu-Wei; Chen, Shean-Jen; Huang, Tung-Yi; Chang, Chia-Yuan; Chuang, Jih-Ing; Wu, Fong-Sen; Kuo, Yu-Min; Jen, Chauying J

2012-01-01

Different exercise paradigms show differential effects on various forms of memory. We hypothesize that the differential effects of exercises on memory performance are caused by different neuroplasticity changes in relevant brain regions in response to different exercise trainings. We examined the effects of treadmill running (TR) and wheel running (WR) on the Pavlovian fear conditioning task that assesses learning and memory performance associated with the amygdala (cued conditioning) and both the amygdala and hippocampus (contextual conditioning). The skeletal muscle citrate synthase activity, an indicator of aerobic capacity, was elevated in rats received 4 w of TR, but not WR. While both TR and WR elevated the contextual conditional response, only TR facilitated the cued conditional response. Using a single-neuron labeling technique, we found that while both TR and MR enlarged the dendritic field and increased the spine density in hippocampal CA3 neurons, only TR showed these effects in basolateral amygdalar neurons. Moreover, both types of exercise upregulated synaptic proteins (i.e., TrkB and SNAP-25) in the hippocampus; however only TR showed similar effects in the amygdala. Injection of K252a, a TrkB kinase inhibitor, in the dorsal hippocampus or basolateral amygdala abolished the exercise-facilitated contextual or cued fear learning and memory performance, respectively, regardless of the types of exercise. In summary, our results supported that different types of exercise affect the performance of learning and memory via BDNF-TrkB signaling and neuroplasticity in specific brain regions. The brain region-specific neuronal adaptations are possibly induced by various levels of intensity/stress elicited by different types of exercise. Copyright © 2011 Elsevier Inc. All rights reserved.

In pursuit of gamma-ray burst progenitors: the identification of a sub-population of rotating Wolf-Rayet stars

NASA Astrophysics Data System (ADS)

Vink, J. S.; Gräfener, G.; Harries, T. J.

2011-12-01

Long-duration gamma-ray bursts (GRBs) involve the most powerful cosmic explosions since the Big Bang. Whilst it has been established that GRBs are related to the death throes of massive stars, the identification of their elusive progenitors has proved challenging. Theoretical modelling suggests that rotating Wolf-Rayet (WR) stars are the best candidates. Wolf-Rayet stars are thought to be in advanced core burning stages, just prior to explosion, but their strong stellar winds shroud their surfaces, preventing a direct measurement of their rotation. Fortunately, linear spectropolarimetry may be used to probe the flattening of their winds because of stellar spin. Spectropolarimetry surveys have shown that the vast majority of WR stars (80%) have spherically symmetric winds and are therefore rotating slowly, yet a small minority (of 20%) display a spectropolarimetric signature indicative of rotation. Here we find a highly significant correlation between WR objects that carry the signature of stellar rotation and the small subset of WR stars with ejecta nebulae that have only recently transitioned from a previous red sugergiant or luminous blue variable phase. As these youthful WR stars have yet to spin-down because of mass loss, they are the best candidate GRB progenitors identified to date. When we take recently published WR ejecta nebula numbers (of Stock & Barlow 2010, MNRAS, 409, 1429), we find that five out of the six line-effect WR stars are surrounded by ejecta nebulae. The statistics imply that the null hypothesis of no correlation between line-effect WR stars and ejecta nebulae can be rejected at the 0.0004% level. Given that four line-effect and WR ejecta nebula have spectroscopically been confirmed to contain nucleo-synthetic products, we argue that the correlation is both statistically significant and physically convincing. The implication is that we have identified a sub-population of WR stars that fulfils the necessary criteria for making GRBs. Finally, we discuss the potential of identifying GRB progenitors via linear spectropolarimetry with extremely large telescopes.

Towards a better understanding of the evolution of Wolf-Rayet stars and Type Ib/Ic supernova progenitors

NASA Astrophysics Data System (ADS)

Yoon, Sung-Chul

2017-10-01

Hydrogen-deficient Wolf-Rayet (WR) stars are potential candidates of Type Ib/Ic supernova (SN Ib/Ic) progenitors and their evolution is governed by mass-loss. Stellar evolution models with the most popular prescription for WR mass-loss rates given by Nugis & Lamers have difficulties in explaining the luminosity distribution of WR stars of WC and WO types and the SN Ic progenitor properties. Here, we suggest some improvements in the WR mass-loss rate prescription and discuss its implications for the evolution of WR stars and SN Ib/Ic progenitors. Recent studies on Galactic WR stars clearly indicate that the mass-loss rates of WC stars are systematically higher than those of WNE stars for a given luminosity. The luminosity and initial metallicity dependences of WNE mass-loss rates are also significantly different from those of WC stars. These factors have not been adequately considered together in previous stellar evolution models. We also find that an overall increase of WR mass-loss rates by about 60 per cent compared to the empirical values obtained with a clumping factor of 10 is needed to explain the most faint WC/WO stars. This moderate increase with our new WR mass-loss rate prescription results in SN Ib/Ic progenitor models more consistent with observations than those given by the Nugis & Lamers prescription. In particular, our new models predict that the properties of SN Ib and SN Ic progenitors are distinctively different, rather than they form a continuous sequence.

Color excesses, intrinsic colors, and absolute magnitudes of Galactic and Large Magellanic Cloud Wolf-Rayet stars

NASA Technical Reports Server (NTRS)

Vacca, William D.; Torres-Dodgen, Ana V.

1990-01-01

A new method of determining the color excesses of WR stars in the Galaxy and the LMC has been developed and is used to determine the excesses for 44 Galactic and 32 LMC WR stars. The excesses are combined with line-free, narrow-band spectrophotometry to derive intrinsic colors of the WR stars of nearly all spectral subtypes. No correlation of UV spectral index or intrinsic colors with spectral subtype is found for the samples of single WN or WC stars. There is evidence that early WN stars in the LMC have flatter UV continua and redder intrinsic colors than early WN stars in the Galaxy. No separation is found between the values derived for Galactic WC stars and those obtained for LMC WC stars. The intrinsic colors are compared with those calculated from model atmospheres of WR stars and generally good agreement is found. Absolute magnitudes are derived for WR stars in the LMC and for those Galactic WR stars located in clusters and associations for which there are reliable distance estimates.

The massive star O+WR binary γ Velorum

NASA Astrophysics Data System (ADS)

De Marco, O.; Willis, A. J.; Colley, S. R.

2001-12-01

The γ Vel O+WR binary system is known to have colliding winds from its X-ray properties. Here we use the stellar parameters of the two stars in the system, derived from the non-LTE models of De Marco & Schmutz (2000) and De Marco et al. (2000), to aid in the interpretation of the optical line variability in terms of the geometry and distribution of the gas around the two stars. We find that the rich dataset (high signal-to-noise ratio, high resolution optical spectra finely sampling the orbital period) allows a very accurate determination of the opening angle of the wake formed as the WR wind impacts the O star. This can lead to understanding whether radiative breaking (of the WR wind gas by the O star radiation field) is efficient in this system. From the location of the emission line forming regions within the WR wind (from the non-LTE models), and the variability patterns of those lines, it is possible to construct a detailed map of the WR wind. Work financed by the Asimov Fellowship program of the Americam Museum of Natural History.

Voluntary resistance running with short distance enhances spatial memory related to hippocampal BDNF signaling.

PubMed

Lee, Min Chul; Okamoto, Masahiro; Liu, Yu Fan; Inoue, Koshiro; Matsui, Takashi; Nogami, Haruo; Soya, Hideaki

2012-10-15

Although voluntary running has beneficial effects on hippocampal cognitive functions if done abundantly, it is still uncertain whether resistance running would be the same. For this purpose, voluntary resistance wheel running (RWR) with a load is a suitable model, since it allows increased work levels and resultant muscular adaptation in fast-twitch muscle. Here, we examined whether RWR would have potential effects on hippocampal cognitive functions with enhanced hippocampal brain-derived neurotrophic factor (BDNF), as does wheel running without a load (WR). Ten-week-old male Wistar rats were assigned randomly to sedentary (Sed), WR, and RWR (to a maximum load of 30% of body weight) groups for 4 wk. We found that in RWR, work levels increased with load, but running distance decreased by about half, which elicited muscular adaptation for fast-twitch plantaris muscle without causing any negative stress effects. Both RWR and WR led to improved spatial learning and memory as well as gene expressions of hippocampal BDNF signaling-related molecules. RWR increased hippocampal BDNF, tyrosine-related kinase B (TrkB), and cAMP response element-binding (CREB) protein levels, whereas WR increased only BDNF. With both exercise groups, there were correlations between spatial memory and BDNF protein (r = 0.41), p-CREB protein (r = 0.44), and work levels (r = 0.77). These results suggest that RWR plays a beneficial role in hippocampus-related cognitive functions associated with hippocampal BDNF signaling, even with short distances, and that work levels rather than running distance are more determinant of exercise-induced beneficial effects in wheel running with and without a load.

Wolf-Rayet content of the Milky Way

NASA Astrophysics Data System (ADS)

Crowther, P. A.

An overview of the known Wolf-Rayet (WR) population of the Milky Way is presented, including a brief overview of historical catalogues and recent advances based on infrared photometric and spectroscopic observations resulting in the current census of 642 (vl.13 online catalogue). The observed distribution of WR stars is considered with respect to known star clusters, given that ≤20% of WR stars in the disk are located in clusters. WN stars outnumber WC stars at all galactocentric radii, while early-type WC stars are strongly biased against the inner Milky Way. Finally, recent estimates of the global WR population in the Milky Way are reassessed, with 1,200±100 estimated, such that the current census may be 50% complete. A characteristic WR lifetime of 0.25 Myr is inferred for an initial mass threshold of 25 M⊙.

X-ray Observations of Binary and Single Wolf-Rayet Stars with XMM-Newton and Chandra

NASA Technical Reports Server (NTRS)

Skinner, Stephen; Gudel, Manuel; Schmutz, Werner; Zhekov, Svetozar

2006-01-01

We present an overview of recent X-ray observations of Wolf-Rayet (WR) stars with XMM-Newton and Chandra. These observations are aimed at determining the differences in X-ray properties between massive WR + OB binary systems and putatively single WR stars. A new XMM spectrum of the nearby WN8 + OB binary WR 147 shows hard absorbed X-ray emission (including the Fe Ka line complex), characteristic of colliding wind shock sources. In contrast, sensitive observations of four of the closest known single WC (carbon-rich) WR stars have yielded only nondetections. These results tentatively suggest that single WC stars are X-ray quiet. The presence of a companion may thus be an essential factor in elevating the X-ray emission of WC + OB stars to detectable levels.

Newly discovered Wolf-Rayet and weak emission-line central stars of planetary nebulae

NASA Astrophysics Data System (ADS)

DePew, K.; Parker, Q. A.; Miszalski, B.; De Marco, O.; Frew, D. J.; Acker, A.; Kovacevic, A. V.; Sharp, R. G.

2011-07-01

We present the spectra of 32 previously unpublished confirmed and candidate Wolf-Rayet ([WR]) and weak emission-line (WELS) central stars of planetary nebulae (CSPNe). 18 stars have been discovered in the Macquarie/AAO/Strasbourg Hα (MASH) PN survey sample, and we have also uncovered 14 confirmed and candidate [WR]s and WELS among the CSPNe of previously known PNe. Spectral classifications have been undertaken using both Acker & Neiner and Crowther, De Marco & Barlow schemes. 22 members in this sample are identified as probable [WR]s; the remaining 10 appear to be WELS. Observations undertaken as part of the MASH spectroscopic survey have now increased the number of known [WR]s by ˜30 per cent. This will permit a better analysis of [WR] subclass distribution, metallicity effects and evolutionary sequences in these uncommon objects.

77 FR 23278 - Notice of Lodging of Settlement Agreement Pursuant to the Comprehensive Environmental Response...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-18

... Delaware in In re W.R. Grace & Co., Case No. 01-01139 (JFK). The proposed Settlement Agreement would...-01139 (JFK), and D.J. Ref. No. 90-11-2-07106/5. During the public comment period, the settlement...

Effect of early thermal experience on pituitary-gonadal axis in female rats.

PubMed

Kurowicka, Beata; Gajewska, Alina; Franczak, Anita

2006-03-01

The reproductive system fully develops during postnatal stages of life, and as such it may be susceptible to environmental cues such as high temperature. Thus, the purpose of the study was to compare how exposure to 34 degrees Celsius ambient temperature affects pituitary-gonadal axis of immature and adult female rats. Three groups of females at proestrous or metaestrous (n=38) were used in the study. The females were housed in ambient temperature of 34 degrees Celsius (WR group, n=10) or room temperature (CR group, n=16) from birth to adulthood. The females from the third group were acclimated to 34 degrees Celsius as adults (WA group, n=12). In the WR group the onset of puberty was delayed in comparison to the CR group. The plasma PRL level was lower during proestrous and higher during metaestrous in the WR group compared to the CR group. During metaestrous, lower FSH and higher progesterone (P(4)) plasma concentrations were found in the WR females. No changes in LH and oestradiol (E(2)) plasma concentrations were demonstrated. Higher in vitro E(2) and lower P(4) secretions under FSH stimulation were observed in the WR follicles compared to those of the CR group. The WR group also demonstrated higher basal and LH-stimulated luteal in vitro secretion of P(4) than controls. Plasma LH and FSH concentrations during metaestrous were higher in WA females than in the WR group, but PRL level was lower. Follicles of the WA group were unresponsive to FSH with respect to steroid secretion. In addition, LH stimulated luteal E(2) secretion in this group. P(4) release by luteal cells was lower in the WA than in the WR group. We concluded that WR females differ from WA in reproductive system adjustments to rearing temperature and that early thermal experience is more effective in antagonizing the effect of high temperature than acclimation of adult females.

Providing feedback following Leadership WalkRounds is associated with better patient safety culture, higher employee engagement and lower burnout

PubMed Central

Sexton, J Bryan; Adair, Kathryn C; Leonard, Michael W; Frankel, Terri Christensen; Proulx, Joshua; Watson, Sam R; Magnus, Brooke; Bogan, Brittany; Jamal, Maleek; Schwendimann, Rene; Frankel, Allan S

2018-01-01

Background There is a poorly understood relationship between Leadership WalkRounds (WR) and domains such as safety culture, employee engagement, burnout and work-life balance. Methods This cross-sectional survey study evaluated associations between receiving feedback about actions taken as a result of WR and healthcare worker assessments of patient safety culture, employee engagement, burnout and work-life balance, across 829 work settings. Results 16 797 of 23 853 administered surveys were returned (70.4%). 5497 (32.7% of total) reported that they had participated in WR, and 4074 (24.3%) reported that they participated in WR with feedback. Work settings reporting more WR with feedback had substantially higher safety culture domain scores (first vs fourth quartile Cohen’s d range: 0.34–0.84; % increase range: 15–27) and significantly higher engagement scores for four of its six domains (first vs fourth quartile Cohen’s d range: 0.02–0.76; % increase range: 0.48–0.70). Conclusion This WR study of patient safety and organisational outcomes tested relationships with a comprehensive set of safety culture and engagement metrics in the largest sample of hospitals and respondents to date. Beyond measuring simply whether WRs occur, we examine WR with feedback, as WR being done well. We suggest that when WRs are conducted, acted on, and the results are fed back to those involved, the work setting is a better place to deliver and receive care as assessed across a broad range of metrics, including teamwork, safety, leadership, growth opportunities, participation in decision-making and the emotional exhaustion component of burnout. Whether WR with feedback is a manifestation of better norms, or a cause of these norms, is unknown, but the link is demonstrably potent. PMID:28993441

Providing feedback following Leadership WalkRounds is associated with better patient safety culture, higher employee engagement and lower burnout.

PubMed

Sexton, J Bryan; Adair, Kathryn C; Leonard, Michael W; Frankel, Terri Christensen; Proulx, Joshua; Watson, Sam R; Magnus, Brooke; Bogan, Brittany; Jamal, Maleek; Schwendimann, Rene; Frankel, Allan S

2018-04-01

There is a poorly understood relationship between Leadership WalkRounds (WR) and domains such as safety culture, employee engagement, burnout and work-life balance. This cross-sectional survey study evaluated associations between receiving feedback about actions taken as a result of WR and healthcare worker assessments of patient safety culture, employee engagement, burnout and work-life balance, across 829 work settings. 16 797 of 23 853 administered surveys were returned (70.4%). 5497 (32.7% of total) reported that they had participated in WR, and 4074 (24.3%) reported that they participated in WR with feedback. Work settings reporting more WR with feedback had substantially higher safety culture domain scores (first vs fourth quartile Cohen's d range: 0.34-0.84; % increase range: 15-27) and significantly higher engagement scores for four of its six domains (first vs fourth quartile Cohen's d range: 0.02-0.76; % increase range: 0.48-0.70). This WR study of patient safety and organisational outcomes tested relationships with a comprehensive set of safety culture and engagement metrics in the largest sample of hospitals and respondents to date. Beyond measuring simply whether WRs occur, we examine WR with feedback, as WR being done well . We suggest that when WRs are conducted, acted on, and the results are fed back to those involved, the work setting is a better place to deliver and receive care as assessed across a broad range of metrics, including teamwork, safety, leadership, growth opportunities, participation in decision-making and the emotional exhaustion component of burnout. Whether WR with feedback is a manifestation of better norms, or a cause of these norms, is unknown, but the link is demonstrably potent. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Family ties of WR to LBV nebulae yielding clues for stellar evolution

NASA Astrophysics Data System (ADS)

Weis, K.

Luminous Blue Variables (LBVs) are stars is a transitional phase massive stars may enter while evolving from main-sequence to Wolf-Rayet stars. The to LBVs intrinsic photometric variability is based on the modulation of the stellar spectrum. Within a few years the spectrum shifts from OB to AF type and back. During their cool phase LBVs are close to the Humphreys-Davidson (equivalent to Eddington/Omega-Gamma) limit. LBVs have a rather high mass loss rate, with stellar winds that are fast in the hot and slower in the cool phase of an LBV. These alternating wind velocities lead to the formation of LBV nebulae by wind-wind interactions. A nebula can also be formed in a spontaneous giant eruption in which larger amounts of mass are ejected. LBV nebulae are generally small (< 5 pc) mainly gaseous circumstellar nebulae, with a rather large fraction of LBV nebulae being bipolar. After the LBV phase the star will turn into a Wolf-Rayet star, but note that not all WR stars need to have passed the LBV phase. Some follow from the RSG and the most massive directly from the MS phase. In general WRs have a large mass loss and really fast stellar winds. The WR wind may interact with winds of earlier phases (MS, RSG) to form WR nebulae. As for WR with LBV progenitors the scenario might be different, here no older wind is present but an LBV nebula! The nature of WR nebulae are therefore manifold and in particular the connection (or family ties) of WR to LBV nebulae is important to understand the transition between these two phases, the evolution of massive stars, their winds, wind-wind and wind-nebula interactions. Looking at the similarities and differences of LBV and WR nebula, figuring what is a genuine LBV and WR nebula are the basic question addressed in the analysis presented here.

An IRAS-Based Search for New Dusty Late-Type WC Wolf-Rayet Stars

NASA Technical Reports Server (NTRS)

Cohen, Martin

1995-01-01

I have examined all Infrared Astronomical Satellite (IRAS) data relevant to the 173 Galactic Wolf-Rayet (W-R) stars in an updated catalog, including the 13 stars newly discovered by Shara and coworkers. Using the W-R coordinates in these lists, I have examined the IRAS Point Source Catalog (PSC), the Faint Source Catalog, and the Faint Source Reject Catalog, and have generated one-dimensional spatial profiles, 'ADDSCANs', and two-dimensional full-resolution images, 'FRESCOS'. The goal was to assemble the best set of observed IRAS color indices for different W-R types, in particular for known dusty late-type WC Wolf-Rayet (WCL) objects. I have also unsuccessfully sought differences in IRAS colors and absolute magnitudes between single and binary W-R stars. The color indices for the entire ensemble of W-R stars define zones in the IRAS color-color ([12] - [25], [25] - [60])-plane. By searching the PSC for otherwise unassociated sources that satisfy these colors, I have identified potential new W-R candidates, perhaps too faint to have been recognized in previous optical searches. I have extracted these candidates' IRAS low-resolution spectrometer (LRS) data and compared the spectra with the highly characteristic LRS shape for known dusty WCL stars. The 13 surviving candidates must now be ex amined by optical spectroscopy. This work represents a much more rigorous and exhaustive version of the LRS study that identified IRAS 17380 - 3031 (WR98a) as the first new W-R (WC9) star discovered by IPAS. This search should have detected dusty WCL stars to a distance of 7.0 kpc from the Sun, for l is greater than 30 degrees, and to 2.9 kpc even in the innermost galaxy. For free-free-dominated W-R stars the corresponding distances are 2.5 and 1.0 kpc, respectively.

An IRAS-based search for new Dusty Late-Type WC Wolf-Rayet stars

NASA Technical Reports Server (NTRS)

Cohen, Martin

1995-01-01

I have examined all Infrared Astronomical Satellite (IRAS) data relevant to the 173 Galactic Wolf-Rayet (W-R) stars in an updated catalog, including the 13 stars newly discovered by Shara and coworkers. Using the W-R coordinates in these lists, I have examined the IRAS Point Source Catalog (PSC), the Faint Source Catalog, and the Faint Source Reject Catalog, and have generated one-dimensional spatial profiles ('ADDSCANs') and two-dimensional full-resolution images ('FRESCOs'). The goal was to assemble the best set of observed IRAS color indices for different W-R types, in particular for known dusty late-type WC Wolf-Rayet (WCL) objects. I have also unsuccessfully sought differences in IRAS colors and absolute magnitudes between single and binary W-R stars. The color indices for the entire ensemble of W-R stars define zones in the IRAS color-color plane. By searching the PSC for otherwise unassociated sources that satisfy these colors, I have identified potential new W-R candidates, perhaps too faint to have been recognized in previous optical searches. I have extracted these candidates' IRAS low-resolution spectrometer (LRS) data and compared the spectra with the highly characteristic LRS shape for known dusty WCL stars. The 13 surviving candidates must now be examined by optical spectroscopy. This work represents a much more rigorous and exhaustive version of the LRS study that identified IRAS 17380 - 3031 (WR98a) as the first new W-R (WC9) star discovered by IRAS. This search should have detected dusty WCL stars to a distance of 7.0 kpc from the Sun, for the absolute value of l greater than 30 deg, and to 2.9 kpc even in the innermost Galaxy. For free-free-dominated W-R stars the corresponding distances are 2.5 and 1.0 kpc, respectively.

Effects of S-2-(3-Methylaminopropylamino)ethyl Phosphorothioic Acid (WR- 3689), Alone or Combined with Caffeine, on Catecholamine Content of Mouse Hypothalamus

DTIC Science & Technology

1993-01-01

INSTITUTE I cIEINTIFIC•IEPOET SR93-16 Effects of S-2-(3-Methylaminopropylamino)ethyl Phosphorothioic Acid (WR-3689), Alone or Combined with Caffeine...and 220 pg/mg and 69 and 94 pg/mg of hypothalamic tissue, respectively. WR- 3689 had no effect on the content of NE and DA. In contrast, NE increased...increased to 142 ± 13 pg/mg (P < 0.05) 4 hr after injection of 40 mg/kg of caffeine. The combination of WR-3689 and caffeine had no effect on NE and DA

A NEAR-INFRARED SURVEY OF THE INNER GALACTIC PLANE FOR WOLF-RAYET STARS. II. GOING FAINTER: 71 MORE NEW W-R STARS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shara, Michael M.; Faherty, Jacqueline K.; Zurek, David

We are continuing a J, K and narrowband imaging survey of 300 deg{sup 2} of the plane of the Galaxy, searching for new Wolf-Rayet (W-R) stars. Our survey spans 150 Degree-Sign in Galactic longitude and reaches 1 Degree-Sign above and below the Galactic plane. The survey has a useful limiting magnitude of K = 15 over most of the observed Galactic plane, and K = 14 (due to severe crowding) within a few degrees of the Galactic center. Thousands of emission-line candidates have been detected. In spectrographic follow-ups of 146 relatively bright W-R star candidates, we have re-examined 11 previouslymore » known WC and WN stars and discovered 71 new W-R stars, 17 of type WN and 54 of type WC. Our latest image analysis pipeline now picks out W-R stars with a 57% success rate. Star subtype assignments have been confirmed with the K-band spectra and distances approximated using the method of spectroscopic parallax. Some of the new W-R stars are among the most distant known in our Galaxy. The distribution of these new W-R stars is beginning to trace the locations of massive stars along the distant spiral arms of the Milky Way.« less

Fermi-LAT upper limits on gamma-ray emission from colliding wind binaries

DOE PAGES

Werner, Michael; Reimer, O.; Reimer, A.; ...

2013-07-09

Here, colliding wind binaries (CWBs) are thought to give rise to a plethora of physical processes including acceleration and interaction of relativistic particles. Observation of synchrotron radiation in the radio band confirms there is a relativistic electron population in CWBs. Accordingly, CWBs have been suspected sources of high-energy γ-ray emission since the COS-B era. Theoretical models exist that characterize the underlying physical processes leading to particle acceleration and quantitatively predict the non-thermal energy emission observable at Earth. Furthermore, we strive to find evidence of γ-ray emission from a sample of seven CWB systems: WR 11, WR 70, WR 125, WRmore » 137, WR 140, WR 146, and WR 147. Theoretical modelling identified these systems as the most favourable candidates for emitting γ-rays. We make a comparison with existing γ-ray flux predictions and investigate possible constraints. We used 24 months of data from the Large Area Telescope (LAT) on-board the Fermi Gamma Ray Space Telescope to perform a dedicated likelihood analysis of CWBs in the LAT energy range. As a result, we find no evidence of γ-ray emission from any of the studied CWB systems and determine corresponding flux upper limits. For some CWBs the interplay of orbital and stellar parameters renders the Fermi-LAT data not sensitive enough to constrain the parameter space of the emission models. In the cases of WR140 and WR147, the Fermi -LAT upper limits appear to rule out some model predictions entirely and constrain theoretical models over a significant parameter space. A comparison of our findings to the CWB η Car is made.« less

Seal Technology Development for Advanced Component for Airbreathing Engines

NASA Technical Reports Server (NTRS)

Snyder, Philip H.

2008-01-01

Key aspects of the design of sealing systems for On Rotor Combustion/Wave Rotor (ORC/WR) systems were addressed. ORC/WR systems generally fit within a broad class of pressure gain Constant Volume Combustors (CVCs) or Pulse Detonation Combustors (PDCs) which are currently being considered for use in many classes of turbine engines for dramatic efficiency improvement. Technology readiness level of this ORC/WR approaches are presently at 2.0. The results of detailed modeling of an ORC/WR system as applied to a regional jet engine application were shown to capture a high degree of pressure gain capabilities. The results of engine cycle analysis indicated the level of specific fuel consumption (SFC) benefits to be 17 percent. The potential losses in pressure gain due to leakage were found to be closely coupled to the wave processes at the rotor endpoints of the ORC/WR system. Extensive investigation into the sealing approaches is reported. Sensitivity studies show that SFC gains of 10 percent remain available even when pressure gain levels are highly penalized. This indicates ORC/WR systems to have a high degree of tolerance to rotor leakage effects but also emphasizes their importance. An engine demonstration of an ORC/WR system is seen as key to progressing the TRL of this technology. An industrial engine was judged to be a highly advantageous platform for demonstration of a first generation ORC/WR system. Prior to such a demonstration, the existing NASA pressure exchanger wave rotor rig was identified as an opportunity to apply both expanded analytical modeling capabilities developed within this program and to identify and fix identified leakage issues existing within this rig. Extensive leakage analysis of the rig was performed and a detailed design of additional sealing strategies for this rig was generated.

Potential Application of Shallow Bed Wetland Roof systems for green urban cities

NASA Astrophysics Data System (ADS)

Bui, X. T.

2016-12-01

This study aims to investigate the growth, nutrient uptake, domestic wastewater treatment, green (leaf) area and heat reduction of four shallow subsurface flow wetland roof (WR) systems with four different new local plants. Selected species included Cyperus Javanicus Hot (WR1), Eleusine Indica (L.) Gaertn (WR2), Struchium Sparganophorum (L.) Kuntze (WR3) and Kyllinga Brevifolia Rottb (WR4). These systems were operated during 61 days at hydraulic loading rates of 353 - 403 m3/ha.day. The biomass growth of 4.9-73.7g fresh weight/day, and 0.8-11.4 g dry weight/day were observed. The nutrient accumulation according to dry biomass achieved 0.25-2.14% of total nitrogen (TN) and 0.13-1.07% of total phosphorus (TP). The average COD, TN and TP removal was 61-79%; 54-81% and 62-83%, which corresponding to 27-33 kg COD/ha.day, 10-14 kg TN/ha.day and 0.4-0.5 kg TP/ha.day, respectively. The WR4 system achieved the highest COD and TN removal among the WRs. The TP removal efficiency showed an insignificant difference for the systems. Consequently, the treated water quality complied with the Vietnam standard limits (QCVN 14:2008, level B). The green area of the four plants varied between 63-92 m2 green leaf/m2 WR. The WR4 was the highest green area. Moreover, the results also showed the temperature under the flat roof was 1-3°C lower than that of the ambient air. In summary, wetland roof is a promising technology, which not only owns the effective domestic wastewater treatment capacity, but also contributes to green urban with several above benefits.

Comparison of the Impact of the Arctic Oscillation and East Atlantic - West Russia Teleconnection on Interannual Variation in East Asian Winter Temperatures and Monsoon

NASA Technical Reports Server (NTRS)

Lim, Young-Kwon; Kim, Hae-Dong

2014-01-01

The large-scale impacts of the Arctic Oscillation (AO) and the East Atlantic/West Russia (EA/WR) teleconnection on the East Asian winter climate anomalies are compared for the past 34 winters focusing on 1) interannual monthly to seasonal temperature variability, 2) East Asian winter monsoon (EAWM), and 3) the Siberian high (SH) and cold surge. Regression analysis reveals warming by AO and EA/WR over mid-latitude East Asia during their positive phase and vice versa. The EA/WR impact is found to be comparable to the AO impact in affecting the East Asian temperature and monsoon. For example, warm (cold) months over mid-latitude East Asia during the positive (negative) AO are clearly seen when the AO and EA/WR are in the same phase. Near zero correlation is found between temperature and the AO phase when both teleconnections are in an opposite phase. The well-known negative relationship between SH and the AO phase is observed significantly more often when the AO is in the same phase with the EA/WR. Also, the indices of EAWM, cold surge, and SH are found to be more highly negative-correlated with the EA/WR rather than with the AO. The advective temperature change and associated circulation demonstrate that the anomalous large-scale field including the SH over the mid-latitude Asian inland is better represented by the EA/WR, influencing the East Asian winter climates. These results suggest that the impact of EA/WR should be considered more important than previously thought for a better understanding of East Asian winter temperature and monsoon variability.

An Extreme Case of a Misaligned Highly Flattened Wind in the Wolf-Rayet Binary CX Cephei

NASA Astrophysics Data System (ADS)

Villar-Sbaffi, A.; St-Louis, N.; Moffat, Anthony F. J.; Piirola, Vilppu

2006-04-01

CX Cep (WR 151) is the WR+O binary (WN5+O5 V) with the second shortest period known in our Galaxy. To examine the circumstellar matter distribution and to better constraint the orbital parameters and mass-loss rate of the W-R star, we obtained broadband and multiband (i.e., UBVRI) linear polarization observations of the system. Our analysis of the phase-locked polarimetric modulation confirms the high orbital inclination of the system (i.e., i=65deg). Using the orbital solution of Lewis et al. (1993), we obtain masses of 33.9 and 23.9 Msolar for the O and W-R stars, respectively, which agree with their spectral types. A simple polarimetric model accounting for finite stellar size effects allowed us to derive a mass-loss rate for the W-R star of (0.3-0.5)×10-5 Msolar yr-1. This result was remarkably independent of the model's input parameters and favors an earlier spectral type for the W-R component (i.e., WN4). Finally, using our multiband observations, we fitted and subtracted from our data the interstellar polarization. The resulting constant intrinsic polarization of 3%-4% is misaligned in relation to the orbital plane (i.e., θCIP=26deg vs. Ω=75deg) and is the highest intrinsic polarization ever observed for a W-R star. This misalignment points toward a rotational (or magnetic) origin for the asymmetry and contradicts the most recent evolutionary models for massive stars (Meynet & Maeder 2003) that predict spherically symmetric winds during the W-R phase (i.e., CIP=0%).

Are the O stars in WR+O binaries exceptionally rapid rotators?

NASA Astrophysics Data System (ADS)

Reeve, Dominic; Howarth, Ian D.

2018-05-01

We examine claims of strong gravity-darkening effects in the O-star components of WR+O binaries. We generate synthetic spectra for a wide range of parameters, and show that the line-width results are consistent with extensive measurements of O stars that are either single or are members of `normal' binaries. By contrast, the WR+O results are at the extremes of, or outside, the distributions of both models and other observations. Remeasurement of the WR+O spectra shows that they can be reconciled with other results by judicious choice of pseudo-continuum normalization. With this interpretation, the supersynchronous rotation previously noted for the O-star components in the WR+O binaries with the longest orbital periods appears to be unexceptional. Our investigation is therefore consistent with the aphorism that if the title of a paper ends with a question mark, the answer is probably `no'.

Flexitime in an Army Medical Center.

DTIC Science & Technology

1981-04-01

and Costigan (1973) conducted a longitudinal study of employee responses to the four day week in a medium-sized pharmaceutical company. The patterns...New York, New York, 1979. Nord, W.R. and Costigan, R. Worker adjustment to the four - day week : a longitudinal study. Journal of Applied Psychology, 58

The metallicity dependence of WR winds

NASA Astrophysics Data System (ADS)

Hainich, R.; Shenar, T.; Sander, A.; Hamann, W.-R.; Todt, H.

2017-11-01

Wolf-Rayet (WR) stars are the most advanced stage in the evolution of the most massive stars. The strong feedback provided by these objects and their subsequent supernova (SN) explosions are decisive for a variety of astrophysical topics such as the cosmic matter cycle. Consequently, understanding the properties of WR stars and their evolution is indispensable. A crucial but still not well known quantity determining the evolution of WR stars is their mass-loss rate. Since the mass loss is predicted to increase with metallicity, the feedback provided by these objects and their spectral appearance are expected to be a function of the metal content of their host galaxy. This has severe implications for the role of massive stars in general and the exploration of low metallicity environments in particular. Hitherto, the metallicity dependence of WR star winds was not well studied. In this contribution, we review the results from our comprehensive spectral analyses of WR stars in environments of different metallicities, ranging from slightly super-solar to SMC-like metallicities. Based on these studies, we derived empirical relations for the dependence of the WN mass-loss rates on the metallicity and iron abundance, respectively.

Antimutagenicity of WR-1065 in L5178Y cells exposed to accelerated (56)Fe ions

NASA Technical Reports Server (NTRS)

Evans, H. H.; Evans, T. E.; Horng, M. F.

2002-01-01

The ability of the aminothiol WR-1065 [N-(2-mercaptoethyl)-1,3-diaminopropane] to protect L5178Y (LY) cells against the cytotoxic and mutagenic effects of exposure to accelerated (56)Fe ions (1.08 GeV/nucleon) was determined. It was found that while WR-1065 reduced the mutagenicity in both cell lines when it was present during the irradiation, the addition of WR-1065 after the exposure had no effect on the mutagenicity of the radiation in either cell line. No marked protection against the cytotoxic effects of exposure to (56)Fe ions was provided by WR-1065 when added either during or after irradiation in either cell line. We reported previously that WR-1065 protected the LY-S1 and LY-SR1 cell lines against both the cytotoxicity and mutagenicity of X radiation when present during exposure, but that its protection when administered after exposure was limited to the mutagenic effects in the radiation-hypersensitive cell line, LY-S1. The results indicate that the mechanisms involved differ in the protection against cytotoxic compared to mutagenic effects and in the protection against damage caused by accelerated (56)Fe ions compared to X radiation.

Relationships among the serum omega fatty acid levels, serum C-reactive protein levels and arterial stiffness/wave reflection in Japanese men.

PubMed

Tomiyama, Hirofumi; Matsumoto, Chisa; Odaira, Mari; Yamada, Jiko; Yoshida, Masanobu; Shiina, Kazuki; Nagata, Mikio; Yamashina, Akira

2011-08-01

We examined the relationship among the serum omega-3 and omega-6 fatty acid (O3FA and O6FA) levels, serum C-reactive protein (CRP) levels, and arterial stiffness/wave reflection (AS/WR) in healthy Japanese men. In 2206 Japanese healthy men, parameters related to the AS/WR (i.e., brachial-ankle pulse wave velocity and radial arterial pulse wave analysis) were measured. No significant inverse relationships were observed between the serum O3FA levels and the AS/WR-related parameters. Adjusted values of the AS/WR-related parameters and serum CRP levels were higher in the subjects with serum O6FA levels in the highest tertile than in those with serum O6FA levels in the lowest tertile. In healthy Japanese men with known high dietary intakes of O3FAs, the serum O3FA levels may not reflect the pathophysiological abnormalities related to AS/WR. Increased serum O6FA levels appeared to be independently associated with the unfavorable conditions related to AS/WR and inflammation. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

Effects of repetitive shoulder activity on the subacromial space in manual wheelchair users.

PubMed

Lin, Yen-Sheng; Boninger, Michael; Worobey, Lynn; Farrokhi, Shawn; Koontz, Alicia

2014-01-01

This study investigated (1) the effect of repetitive weight-relief raises (WR) and shoulder external rotation (ER) on the acromiohumeral distance (AHD) among manual wheelchair users (MWUs) and (2) the relationship between shoulder pain, subject characteristics, and AHD changes. Twenty-three MWUs underwent ultrasound imaging of the nondominant shoulder in an unloaded baseline position and while holding a WR position before and after the WR/ER tasks. Paired t-tests and Spearman correlational analysis were used to assess differences in the AHD before and after each task and the relationships between pain, subject characteristics, and the AHD measures. A significant reduction in the subacromial space (P<0.01) occurred when subjects performed a WR position compared to baseline. Individuals with increased years of disability had greater AHD percentage narrowing after WR (P=0.008). Increased shoulder pain was associated with AHD percentage narrowing after ER (P≤0.007). The results support clinical practice guidelines that recommend MWUs limit WR to preserve shoulder function. The isolated repetitive shoulder activity did not contribute to the changes of subacromial space in MWUs. The ultrasonographic measurement of the AHD may be a target for identifying future interventions that prevent pain.

Effects of Repetitive Shoulder Activity on the Subacromial Space in Manual Wheelchair Users

PubMed Central

Lin, Yen-Sheng; Boninger, Michael; Worobey, Lynn; Farrokhi, Shawn; Koontz, Alicia

2014-01-01

This study investigated (1) the effect of repetitive weight-relief raises (WR) and shoulder external rotation (ER) on the acromiohumeral distance (AHD) among manual wheelchair users (MWUs) and (2) the relationship between shoulder pain, subject characteristics, and AHD changes. Twenty-three MWUs underwent ultrasound imaging of the nondominant shoulder in an unloaded baseline position and while holding a WR position before and after the WR/ER tasks. Paired t-tests and Spearman correlational analysis were used to assess differences in the AHD before and after each task and the relationships between pain, subject characteristics, and the AHD measures. A significant reduction in the subacromial space (P < 0.01) occurred when subjects performed a WR position compared to baseline. Individuals with increased years of disability had greater AHD percentage narrowing after WR (P = 0.008). Increased shoulder pain was associated with AHD percentage narrowing after ER (P ≤ 0.007). The results support clinical practice guidelines that recommend MWUs limit WR to preserve shoulder function. The isolated repetitive shoulder activity did not contribute to the changes of subacromial space in MWUs. The ultrasonographic measurement of the AHD may be a target for identifying future interventions that prevent pain. PMID:25215283

The Citius End: World Records Progression Announces the Completion of a Brief Ultra-Physiological Quest

PubMed Central

Berthelot, Geoffroy; Thibault, Valérie; Tafflet, Muriel; Escolano, Sylvie; El Helou, Nour; Jouven, Xavier; Hermine, Olivier; Toussaint, Jean-François

2008-01-01

World records (WR) in sports illustrate the ultimate expression of human integrated muscle biology, through speed or strength performances. Analysis and prediction of man's physiological boundaries in sports and impact of external (historical or environmental) conditions on WR occurrence are subject to scientific controversy. Based on the analysis of 3263 WR established for all quantifiable official contests since the first Olympic Games, we show here that WR progression rate follows a piecewise exponential decaying pattern with very high accuracy (mean adjusted r2 values = 0.91±0.08 (s.d.)). Starting at 75% of their estimated asymptotic values in 1896, WR have now reached 99%, and, present conditions prevailing, half of all WR will not be improved by more than 0,05% in 2027. Our model, which may be used to compare future athletic performances or assess the impact of international antidoping policies, forecasts that human species' physiological frontiers will be reached in one generation. This will have an impact on the future conditions of athlete training and on the organization of competitions. It may also alter the Olympic motto and spirit. PMID:18253499

XMM-Newton X-ray Observatory Guest Observer program (AO-1) at CASA

NASA Technical Reports Server (NTRS)

Skinner, Stephen L.

2003-01-01

In this research program, we obtained and analyzed X-ray observations of the Wolf-Rayet (WR) star WR 110 (HD 165688) using the XMM-Newton space-based observatory. Radio observations were also obtained using the Very Large Array (VLA) radio telescope located in New Mexico and operated by the Natl. Radio Astronomy Observatory (NRAO). This star was targeted for observations primarily because it is believed to be a single WR star without a companion. Single WR stars are thought to emit X-rays from cool plasma in shocks distributed throughout their powerful stellar winds. However, there has been little observational work done to test this idea since single WR stars are relatively weak X-ray sources and have been difficult to detect with previous generation telescopes. The launch of XMM-Newton provides a new telescope that is much more sensitive than its predecessors, allowing single WR stars to be studied in detail for the first time. X-ray emission was clearly detected from WR 110. Analysis of its spectrum yields a surprising result. Its X-ray emitting plasma is distributed over a range of temperatures and is dominated by relatively cool plasma with a characteristic temperature T is approximately 6 million K. Such plasma can be explained by existing theoretical wind shock models. However, the spectrum also shows hotter plasma whose temperature is uncertain but is thought to be in excess of T approximately 30 million K. The origin of this hotter plasma is yet unknown, but possible mechanisms are identified

Effects of dietary carbohydrate replaced with wild rice (Zizania latifolia (Griseb) Turcz) on insulin resistance in rats fed with a high-fat/cholesterol diet.

PubMed

Han, Shufen; Zhang, Hong; Qin, Liqiang; Zhai, Chengkai

2013-02-15

Wild rice (WR) is a very nutritious grain that has been used to treat diabetes in Chinese medicinal practice. City diet (CD) is based on the diet consumed by Asian area residents in modern society, which is rich in saturated fats, cholesterol and carbohydrates. The present study was aimed at evaluating the effects of replacing white rice and processed wheat starch of CD with WR as the chief source of dietary carbohydrates on insulin resistance in rats fed with a high-fat/cholesterol diet. Except the rats of the low-fat (LF) diet group, the rats of the other three groups, including to high-fat/cholesterol (HFC) diet, CD and WR diet, were fed with high-fat/cholesterol diets for eight weeks. The rats fed with CD exhibited higher weight gain and lower insulin sensitivity compared to the rats consuming a HFC diet. However, WR suppressed high-fat/cholesterol diet-induced insulin resistance. WR decreased liver homogenate triglyceride and free fatty acids levels, raised serum adiponectin concentration and reduced serum lipocalin-2 and visfatin concentrations. In addition, the WR diet potently augmented the relative expressions of adiponectin receptor 2, peroxisome proliferator-activated receptors, alpha and gamma, and abated relative expressions of leptin and lipocalin-2 in the tissues of interest. These findings indicate that WR is effective in ameliorating abnormal glucose metabolism and insulin resistance in rats, even when the diet consumed is high in fat and cholesterol.

Design and Rationale of a Comparative Effectiveness Study to Evaluate Two Acupuncture Methods for the Treatment of Headaches Associated with Traumatic Brain Injury

PubMed Central

Lee, Courtney; Wallerstedt, Dawn; Duncan, Alaine; York, Alexandra; Hollifield, Michael; Niemtzow, Richard C.; Burns, Stephen M.

2011-01-01

Abstract Background Exposure to deployment and battle can induce a constellation of physical, cognitive, psychological, and behavioral symptoms, also referred to as war-related Trauma Spectrum Response (wrTSR). One prevalent cause of this response is traumatic brain injury (TBI) and its ensuing sequelae, such as pain and suffering caused by post-traumatic headache. Current pharmacologic treatment of these headaches is often inadequate and complicated by the multi-component nature of wrTSR. Acupuncture has been found to reduce pain, improve health-related quality of life, prevent migraine headaches, and reduce tension-type and chronic daily headaches. Objective An ongoing study is endeavoring to advance understanding of the speed and depth of healing induced by two acupuncture approaches, compared to current standard practice and with the aim of providing insights to guide future implementation of acupuncture treatment in the military. Design A comparative effectiveness study protocol will be used to determine if auricular acupuncture (AA) or semi-standardized traditional Chinese acupuncture (TCA) alleviates headaches and reduces associated comorbidities more effectively than usual care alone in a cohort of active duty military personnel with mild-to-moderate TBI. Summary Given that the study is currently underway, no results or conclusions can be reported at present. While current evidence from acupuncture research demonstrates its promising healing impact across the wrTSR, a number of unanswered questions and information gaps remain. It is hoped that the proposed study will address some of these questions and gaps.

A Military Vignette for a Heterogeneous Data Proximity Tool (HDPT) Study

DTIC Science & Technology

2013-06-01

religion) member of HDPT binary Mild theology = Mld; radical theology = Rad Skill HDPT nominal Photography = PH; writing = WR; electrical = EL...photography (PH), writing (WR), driving (DR), computer (CO), electrical (EL), and financial (FI). There are no embedded trends within skill values...Still Serving Skill: WR ( Writing ) Address: HAV (Hanover Village) Education Level: High Ridha Mahdi El-Mofty (S7) Tribal Affiliation is Pastu Criminal

Drug Evaluation in the Plasmodium Falciparum - Aotus Model

DTIC Science & Technology

1986-10-01

blood schizonticidal/curative activity of experimental antimalarial drugs. WR 245082, an acridineainine, at similar doses cured infections of chloroquine ...Guinea - Chesson strain). The curative activity of WR 245082, an acridineamine, for chloroquine - sensitive and chloroquine -resistant strains of P...antimalarial activity of two analogues of the amino acid histidine was assessed against infections of the Uganda Palo Alto strain. WR 251853, 2-fluoro-l

Extreme Wolf-Rayet Galaxies with HST/COS: Understanding CIII] Emission in the Reionization Era

NASA Astrophysics Data System (ADS)

Stark, Daniel

2017-08-01

The first deep spectra of reionization-era galaxies have revealed strong UV nebular emission in high-ionization lines. This is in striking contrast to massive galaxies at lower redshifts, where emission from CIII], OIII], HeII, and CIV is rarely seen. These lines will likely be the only probe available for the most distant galaxies JWST will detect; but we are still unprepared to interpret them. Modeling predicts that intense UV nebular emission can only be produced below a tenth solar metallicity. However, recent HST/COS observations of local galaxies suggest that extreme populations of Wolf-Rayet (WR) stars, the hot exposed cores of massive O stars, may be capable of powering CIII] at metallicities as high as a half-solar. If these moderately metal-poor extreme WR galaxies are indeed a viable source of strong CIII] emission, our interpretation of CIII] detections in the reionization era will be dramatically altered; but we presently have sufficient UV coverage for only three examples. Here, we propose HST/COS G160M and G185M observations of an additional seven extreme WR galaxies spanning 0.5 dex in metallicity around half-solar. These observations will constrain the maximum CIII] equivalent width these galaxies can power as a function of metallicity. The moderate resolution gratings will robustly characterize the massive O and WR star populations, allowing us to link the nebular emission directly to the massive stars responsible. These data will provide a stringent test for the population synthesis codes which will be applied to JWST observations. Without this empirical baseline, our understanding of the most distant galaxies JWST finds will be severely limited.

Rendering potential wearable robot designs with the LOPES gait trainer.

PubMed

Koopman, B; van Asseldonk, E H F; van der Kooij, H; van Dijk, W; Ronsse, R

2011-01-01

In recent years, wearable robots (WRs) for rehabilitation, personal assistance, or human augmentation are gaining increasing interest. To make these devices more energy efficient, radical changes to the mechanical structure of the device are being considered. However, it remains very difficult to predict how people will respond to, and interact with, WRs that differ in terms of mechanical design. Users may adjust their gait pattern in response to the mechanical restrictions or properties of the device. The goal of this pilot study is to show the feasibility of rendering the mechanical properties of different potential WR designs using the robotic gait training device LOPES. This paper describes a new method that selectively cancels the dynamics of LOPES itself and adds the dynamics of the rendered WR using two parallel inverse models. Adaptive frequency oscillators were used to get estimates of the joint position, velocity, and acceleration. Using the inverse models, different WR designs can be evaluated, eliminating the need to build several prototypes. As a proof of principle, we simulated the effect of a very simple WR that consisted of a mass attached to the ankles. Preliminary results show that we are partially able to cancel the dynamics of LOPES. Additionally, the simulation of the mass showed an increase in muscle activity but not in the same level as during the control, where subjects actually carried the mass. In conclusion, the results in this paper suggest that LOPES can be used to render different WRs. In addition, it is very likely that the results can be further optimized when more effort is put in retrieving proper estimations for the velocity and acceleration, which are required for the inverse models. © 2011 IEEE

Thermal destruction of organic waste hydrophobicity for agricultural soils application.

PubMed

Comino, Francisco; Aranda, Víctor; Domínguez-Vidal, Ana; Ayora-Cañada, María José

2017-11-01

Use of organic amendments is a good strategy for combating the growing problem of soil degradation due to deterioration of organic matter content, particularly severe in semi-arid European Mediterranean regions, while at the same time providing an opportunity for recycling organic wastes. Olive mill pomace (OMP), the main by-product of the olive oil industry, is being used increasingly in olive grove soils for this purpose. Although the positive effects of OMP amendments have been widely studied, they also have some negative effects on soil. One of the most critical is that they increase water repellency (WR) due to the presence of poorly evolved, strongly aliphatic compounds. This detrimental effect has received very little attention, although it may impair plant water availability and infiltration rates, increase erosion and lower long-term soil quality. This study proposed, for the first time, thermal treatment as an effective way of reducing WR in organic amendments (i.e. mixtures of OMP, olive tree pruning, chicken manure and spent coffee grounds) prior to their application to soil. Thermal treatment at 275 °C proved effective in removing WR, while lower temperatures (175 or 225 °C) can even increase it. Changes by thermal treatment in the characteristics of the organic amendments studied with FTIR and UV-Vis spectroscopy and thermogravimetric analysis showed that it strongly reduced the aliphatic compounds mainly responsible for their hydrophobicity, concentrated aromatic compounds and increased thermostability. Heating also reduced phytotoxicity, making all of the organic amendments usable in the field (germination index over 100%). Therefore, heating at 275 °C could be an acceptable option for removing WR from organic amendments, enhancing their quality with more stable evolved characteristics. Copyright © 2017 Elsevier Ltd. All rights reserved.

Protection of mice against mixed fission neutron-gamma (n: gamma = 1:1) irradiation by WR-2721, 16,16-dimethyl PGE2, and the combination of both agents

DOE Office of Scientific and Technical Information (OSTI.GOV)

Steel, L.K.; Walden, T.L. Jr.; Hughes, H.N.

1988-09-01

The survival of mice after whole-body exposure to a modified fission neutron-gamma field (n: gamma = 1:1) was used to examine radiation protection by WR-2721, 16,16-dimethyl PGE2(DiPGE2), and the combination of both agents. Administration of WR-2721 (453 mg/kg) increased the LD50/30 from 5.24 to 7.17 Gy (DMF = 1.37), whereas pretreatment with DiPGE2 (1.6 mg/kg) increased the LD50/30 to 5.77 Gy (dose modification factor (DMF) = 1.10). The combination of 453 mg/kg WR-2721 and 0.4 mg/kg DiPGE2 resulted in an LD50/30 of 7.33 Gy, yielding a DMF of 1.39. However, no significant difference in protection was obtained with the combinationmore » of the two agents compared to that seen with WR-2721 alone.« less

Statistical properties of relative weight distributions of four salmonid species and their sampling implications

USGS Publications Warehouse

Hyatt, M.W.; Hubert, W.A.

2001-01-01

We assessed relative weight (Wr) distributions among 291 samples of stock-to-quality-length brook trout Salvelinus fontinalis, brown trout Salmo trutta, rainbow trout Oncorhynchus mykiss, and cutthroat trout O. clarki from lentic and lotic habitats. Statistics describing Wr sample distributions varied slightly among species and habitat types. The average sample was leptokurtotic and slightly skewed to the right with a standard deviation of about 10, but the shapes of Wr distributions varied widely among samples. Twenty-two percent of the samples had nonnormal distributions, suggesting the need to evaluate sample distributions before applying statistical tests to determine whether assumptions are met. In general, our findings indicate that samples of about 100 stock-to-quality-length fish are needed to obtain confidence interval widths of four Wr units around the mean. Power analysis revealed that samples of about 50 stock-to-quality-length fish are needed to detect a 2% change in mean Wr at a relatively high level of power (beta = 0.01, alpha = 0.05).

Randomized, Double-Blinded, Phase 2 Trial of WR 279,396 (Paromomycin and Gentamicin) for Cutaneous Leishmaniasis in Panama

PubMed Central

Sosa, Néstor; Capitán, Zeuz; Nieto, Javier; Nieto, Melissa; Calzada, José; Paz, Hector; Spadafora, Carmenza; Kreishman-Deitrick, Mara; Kopydlowski, Karen; Ullman, Diane; McCarthy, William F.; Ransom, Janet; Berman, Jonathan; Scott, Charles; Grogl, Max

2013-01-01

In this randomized, double-blinded Phase 2 trial, 30 patients with Leishmania panamensis cutaneous leishmaniasis were randomly allocated (1:1) to receive once daily topical treatment with WR 279,396 (15% paromomycin + 0.5% gentamicin) or Paromomycin Alone (15% paromomycin) for 20 days. The index lesion cure rate after 6 months follow-up was 13 of 15 (87%) for WR 279,396 and 9 of 15 (60%) for Paromomycin Alone (P = 0.099). When all treated lesions were included, the final cure rate for WR 279,398-treated patients was again 87%, but the final cure rate for Paromomycin Alone-treated patients was 8 of 15 (53.3%; P = 0.046). Both creams were well tolerated with mild application site reactions being the most frequent adverse event. The increased final cure rate in the WR 279,396 group in this small Phase 2 study suggests that the combination product may provide greater clinical benefit than paromomycin monotherapy against L. panamensis cutaneous leishmaniasis. PMID:23857024

Time-resolved comparative metabolomes for Koji fermentation with brown-, white-, and giant embryo-rice.

PubMed

Lee, Da Eun; Lee, Sunmin; Singh, Digar; Jang, Eun Seok; Shin, Hye Won; Moon, Byoung Seok; Lee, Choong Hwan

2017-09-15

A time-resolved non-targeted metabolomic study towards evaluating the effects of three rice substrate types viz., white rice (WR), giant embryo rice (GER), and brown rice (BR), on Koji fermentation was performed. Notwithstanding the relatively higher proportions of metabolites in unfermented BR (BR 0>WR 0, GER 0), the relative levels of metabolic repertoire in BR Koji were marginally enhanced during 36h fermentation except those for phenolic acids, fatty acids, and vitamins. The WR Koji showed higher levels of lysophospholipids (LysoPC's) and protease-released amino acids (WR 36>GER 36>BR 36). The higher β-glucosidase activity in GER Koji effected the increased levels of sugars and flavonoid aglycons complementing its higher antioxidant activity (GER Koji>BR Koji∼WR Koji). The present study holistically underpins the dynamic metabolomes and enzymatic states during rice Koji fermentation with varying substrate types. The present study finds applications in optimization of commercial Koji production. Copyright © 2017 Elsevier Ltd. All rights reserved.

A Rare Encounter with Very Massive Stars in NGC 3125-A1

NASA Astrophysics Data System (ADS)

Wofford, Aida; Leitherer, Claus; Chandar, Rupali; Bouret, Jean-Claude

2014-02-01

Super star cluster A1 in the nearby starburst galaxy NGC 3125 is characterized by broad He II λ1640 emission (FWHM ~ 1200 km s-1) of unprecedented strength (equivalent width, EW = 7.1 ± 0.4 Å). Previous attempts to characterize the massive star content in NGC 3125-A1 were hampered by the low resolution of the UV spectrum and the lack of co-spatial panchromatic data. We obtained far-UV to near-IR spectroscopy of the two principal emitting regions in the galaxy with the Space Telescope Imaging Spectrograph and the Cosmic Origins Spectrograph on board the Hubble Space Telescope. We use these data to study three clusters in the galaxy, A1, B1, and B2. We derive cluster ages of 3-4 Myr, intrinsic reddenings of E(B - V) = 0.13, 0.15, and 0.13, and cluster masses of 1.7 × 105, 1.4 × 105, and 1.1 × 105 M ⊙, respectively. A1 and B2 show O V λ1371 absorption from massive stars, which is rarely seen in star-forming galaxies, and have Wolf-Rayet (WR) to O star ratios of N(WN5-6)/N(O) = 0.23 and 0.10, respectively. The high N(WN5-6)/N(O) ratio of A1 cannot be reproduced by models that use a normal initial mass function (IMF) and generic WR star line luminosities. We rule out that the extraordinary He II λ1640 emission and O V λ1371 absorption of A1 are due to an extremely flat upper IMF exponent, and suggest that they originate in the winds of very massive (>120 M ⊙) stars. In order to reproduce the properties of peculiar clusters such as A1, the present grid of stellar evolution tracks implemented in Starburst99 needs to be extended to masses >120 M ⊙.

N-(2-Mercaptoethyl)-1,3-Propanediamine (WR-1065) Protects Thymocytes from Programed Cell Death

DTIC Science & Technology

1992-03-15

and most characteristic biohemical marker for apoptosts is calcium lontophores stimulate a suicide process in nuclear DNA fragmentation Into...1065 the dephosphory- exposed to -7-radiation. dexamethazone. or calcium lated form of WR-2721 and generally considered to be Ionophore A23187. WR...33258 fluorochrome was purchased from Calbiochem-Rehring. La Jolla, CA: Dexameth- azone and calcium lonophore A23 187 were purchased from Sigmatos

Hypolipidemic action of chrysin on Triton WR-1339-induced hyperlipidemia in female C57BL/6 mice.

PubMed

Zarzecki, Micheli Stéfani; Araujo, Stífani M; Bortolotto, Vandreza C; de Paula, Mariane Trindade; Jesse, Cristiano Ricardo; Prigol, Marina

2014-01-01

Chrysin (5,7-dihydroxyflavone) is a flavonoid, natural component of traditional medicinal herbs, present in honey, propolis and many plant extracts. The objective of this study was to investigate the hypolipidemic properties of chrysin on Triton WR-1339-induced hyperlipidemia in female C57BL/6 mice. Triton WR-1339 was administered intraperitoneally (400 mg/kg) to overnight-fasted mice to develop acute hyperlipidemia. Chrysin was administered orally (10 mg/kg) 30 min before Triton WR-1339. At 24 h after Triton WR-1339 injection, blood samples were collected to measure plasma lipid levels. The hepatic thiobarbituric acid reactive substances (TBARS), carbonyl content, non-protein sulfhydryl (NPSH) and ascorbic acid (AA) levels, as well as catalase (CAT) and superoxide dismutase (SOD) activity were recorded. Chrysin administration significantly decreased total cholesterol levels. In addition, it partially decreased non-high density lipoprotein-cholesterol and triglycerides levels in plasma of hyperlipidaemic mice. In addition chrysin administration prevented the increase on TBARS levels and prevented the decrease in SOD activity induced by Triton WR-1339. These findings indicated that chrysin was able to decrease plasma lipids concentration and that its antioxidant properties was, at least in part, involved in the hypolipidaemic action of chrysin.

A deep near-infrared spectroscopic survey of the Scutum-Crux arm for Wolf-Rayet stars

NASA Astrophysics Data System (ADS)

Rosslowe, C. K.; Crowther, Paul A.

2018-01-01

We present a New Technology Telescope/Son-of-Isaac spectroscopic survey of infrared selected Wolf-Rayet (WR) candidates in the Scutum-Crux spiral arm (298° ≤ l ≤ 340°, |b| ≤ 0.5°. We obtained near-IR spectra of 127 candidates, revealing 17 WR stars - a ∼13 per cent success rate - of which 16 are newly identified here. The majority of the new WR stars are classified as narrow-lined WN5-7 stars, with two broad-lined WN4-6 stars and three WC6-8 stars. The new stars, with distances estimated from previous absolute magnitude calibrations, have no obvious association with the Scutum-Crux arm. Refined near-infrared (YHJK) classification criteria based on over a hundred Galactic and Magellanic Cloud WR stars, providing diagnostics for hydrogen in WN stars, plus the identification of WO stars and intermediate WN/C stars. Finally, we find that only a quarter of WR stars in the survey region are associated with star clusters and/or H II regions, with similar statistics found for luminous blue variables (LBVs) in the Milky Way. The relative isolation of evolved massive stars is discussed, together with the significance of the co-location of LBVs and WR stars in young star clusters.

The Orbit and Distance of WR140

NASA Astrophysics Data System (ADS)

Dougherty, S. M.; Trenton, V.; Beasley, A. J.

2011-01-01

A campaign of 35 epochs of milli-arcsecond resolution VLBA observations of the archetype colliding-wind WR+O star binary system WR 140 show the wind-collision region (WCR) as a bow-shaped arc of emission that rotates as the highly eccentric orbit progresses. The observations comprise 21 epochs from the 1993-2001 orbit, discussed by Dougherty et al. (2005), and 14 epochs from the 2001-2009 orbit, and span orbital phase 0.43 to 0.95. Assuming the WCR is symmetric about the line-of-centres of the two stars and ``points'' at the WR star, this rotation shows the O star moving from SE to E of the WR star between these orbital phases. Using IR interferometry observations from IOTA that resolve both stellar components at phase 0.297 in conjunction with orbital parameters derived from radial velocity variations, the VLBA observations constrain the inclination of the orbit plane as 120°±4°, the longitude of the ascending node as 352°±2°, and the orbit semi-major axis as 9.0±0.1 mas. This leads to a distance estimate to WR 140 of 1.81±0.08 kpc. Further refinements of the orbit and distance await more IR interferometric observations of the stellar components directly.

Genetic Bases of Fungal White Rot Wood Decay Predicted by Phylogenomic Analysis of Correlated Gene-Phenotype Evolution.

PubMed

Nagy, László G; Riley, Robert; Bergmann, Philip J; Krizsán, Krisztina; Martin, Francis M; Grigoriev, Igor V; Cullen, Dan; Hibbett, David S

2017-01-01

Fungal decomposition of plant cell walls (PCW) is a complex process that has diverse industrial applications and huge impacts on the carbon cycle. White rot (WR) is a powerful mode of PCW decay in which lignin and carbohydrates are both degraded. Mechanistic studies of decay coupled with comparative genomic analyses have provided clues to the enzymatic components of WR systems and their evolutionary origins, but the complete suite of genes necessary for WR remains undetermined. Here, we use phylogenomic comparative methods, which we validate through simulations, to identify shifts in gene family diversification rates that are correlated with evolution of WR, using data from 62 fungal genomes. We detected 409 gene families that appear to be evolutionarily correlated with WR. The identified gene families encode well-characterized decay enzymes, e.g., fungal class II peroxidases and cellobiohydrolases, and enzymes involved in import and detoxification pathways, as well as 73 gene families that have no functional annotation. About 310 of the 409 identified gene families are present in the genome of the model WR fungus Phanerochaete chrysosporium and 192 of these (62%) have been shown to be upregulated under ligninolytic culture conditions, which corroborates the phylogeny-based functional inferences. These results illuminate the complexity of WR and suggest that its evolution has involved a general elaboration of the decay apparatus, including numerous gene families with as-yet unknown exact functions. © The Author 2016. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Suboptimal Weight Loss and Weight Regain after Gastric Bypass Surgery-Postoperative Status of Energy Intake, Eating Behavior, Physical Activity, and Psychometrics.

PubMed

Amundsen, Tina; Strømmen, Magnus; Martins, Catia

2017-05-01

Suboptimal weight loss (SWL) and weight regain (WR) after gastric bypass surgery (GB) remains poorly understood. This study aims to compare GB patients experiencing SWL or significant WR (SigWR) with successful controls, regarding postoperative food intake, eating behavior, physical activity (PA), and psychometrics. Forty-nine patients with >1 year post-surgery were classified as either experiencing SWL (excess body weight loss, EWL, <50%, n = 22) or SigWR (total weight regain ≥15%, n = 38), with respective control groups. Energy intake (EI) was measured with a Food Frequency Questionnaire, eating behavior using the Dutch Eating Behavior Questionnaire and the Three-Factor Eating Questionnaire, and PA using both SenseWear Armbands and the International Physical Activity Questionnaire. Eating disorders, depression, and quality of life (QoL) were measured using the Eating Disorder Examination Questionnaire, Beck Depression Inventory II, and Impact of Weight on Quality of Life, respectively. EI, macronutrient distribution, and meal frequency were similar among groups. However, disinhibited eating behavior score was higher, while most subcategories from IWQOL were significantly lower in both SWL and SigWR groups compared with their respective controls. PA was significantly lower in the SWL and SigWR groups compared with the respective controls. There were no differences between groups regarding depression. Lower PA levels, disordered eating behavior and lower QoL are associated with unsuccessful weigh loss outcome after GB surgery. Longitudinal studies are needed to clarify the potential causal relationship between the previously described variables and SWL/SigWR after GB.

Success in Developing Regions: World Records Evolution through a Geopolitical Prism

PubMed Central

Guillaume, Marion; Helou, Nour El; Nassif, Hala; Berthelot, Geoffroy; Len, Stéphane; Thibault, Valérie; Tafflet, Muriel; Quinquis, Laurent; Desgorces, François; Hermine, Olivier; Toussaint, Jean-François

2009-01-01

A previous analysis of World Records (WR) has revealed the potential limits of human physiology through athletes' personal commitment. The impact of political factors on sports has only been studied through Olympic medals and results. Here we studied 2876 WR from 63 nations in four summer disciplines. We propose three new indicators and show the impact of historical, geographical and economical factors on the regional WR evolution. The south-eastward path of weighted annual barycenter (i.e. the average of country coordinates weighting by the WR number) shows the emergence of East Africa and China in WR archives. Home WR ratio decreased from 79.9% before the second World War to 23.3% in 2008, underlining sports globalization. Annual Cumulative Proportions (ACP, i.e. the cumulative sum of the WR annual rate) highlight the regional rates of progression. For all regions, the mean slope of ACP during the Olympic era is 0.0101, with a maximum between 1950 and 1989 (0.0156). For European countries, this indicator reflects major historical events (slowdown for western countries after 1945, slowdown for eastern countries after 1990). Mean North-American ACP slope is 0.0029 over the century with an acceleration between 1950 and 1989 at 0.0046. Russia takes off in 1935 and slows down in 1988 (0.0038). For Eastern Europe, maximal progression is seen between 1970 and 1989 (0.0045). China starts in 1979 with a maximum between 1990 and 2008 (0.0021), while other regions have largely declined (mean ACP slope for all other countries  = 0.0011). A similar trend is observed for the evolution of the 10 best performers. The national analysis of WR reveals a precise and quantifiable link between the sport performances of a country, its historical or geopolitical context, and its steps of development. PMID:19862324

A phase I study of WR-2721 in combination with total body irradiation (TBI) in patients with refractory lymphoid malignancies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Coia, L.; Krigel, R.; Hanks, G.

This Phase I study was designed to establish the maximum tolerated dose (MTD) of WR-2721 when given twice weekly with total body irradiation (TBI) in the treatment of patients with advanced refractory lymphoid malignancies and to define the toxicities of this combination and schedule. Patients eligible for this study had advanced recurrent indolent non-Hodgkin's lymphoma (NHL) or chronic lymphocytic leukemia (CLL). Patients had symptomatic or progressive disease, a performance status of 0, 1, or 2, and adequate bone marrow, hepatic, and renal function. Only patients failing one or two regimens of prior chemotherapy were eligible. Patients who had received priormore » extended field irradiation were ineligible. Patients received TBI twice weekly (Tuesday and Friday) to a total of 10 doses at 15 cGy/fx. WR-2721 was given intravenously over 15 min beginning 30 min before irradiation. The escalation of WR-2721 was Level 1: 740 mg/m2 and Level 2: 910 mg/m2. The MTD of WR-2721 was that dose which produced predictable and reversible toxicity and would not interfere with patient well-being. Seven patients were entered onto the study, three at 740 mg/m2 and four at 910 mg/m2. Five patients had CLL and two patients small lymphocytic NHL. No patient had hypotension or nausea requiring reduction in dose level or even interruption of infusion of WR-2721. At 740 mg/m2 no grade 3 or 4 toxicities related to WR-2721 were observed, but two patients could not complete treatment because of TBI-induced prolonged thrombocytopenia following treatments 5 and 8. One patient completed all 10 treatments. At 910 mg/m2 of WR-2721, two patients requested removal from study because of malaise, one after 5 cycles and one after 7 cycles. One patient completed all 10 treatments.« less

Overexpression of transcription factor OsWR2 1 regulates wax/cutin biosynthesis and enhances drought tolerance in rice

USDA-ARS?s Scientific Manuscript database

Drought is the major abiotic stress limiting crop production. Plant cuticle represents the outer-most layer of the epidermis and previous studies demonstrate its association with plant response to climatological drought. We report here the functional characterization of the rice ((Oryza sativa L.) W...

Spectroscopy of the archetype colliding-wind binary WR 140 during the 2009 January periastron passage

NASA Astrophysics Data System (ADS)

Fahed, R.; Moffat, A. F. J.; Zorec, J.; Eversberg, T.; Chené, A. N.; Alves, F.; Arnold, W.; Bergmann, T.; Corcoran, M. F.; Correia Viegas, N. G.; Dougherty, S. M.; Fernando, A.; Frémat, Y.; Gouveia Carreira, L. F.; Hunger, T.; Knapen, J. H.; Leadbeater, R.; Marques Dias, F.; Martayan, C.; Morel, T.; Pittard, J. M.; Pollock, A. M. T.; Rauw, G.; Reinecke, N.; Ribeiro, J.; Romeo, N.; Sánchez-Gallego, J. R.; Dos Santos, E. M.; Schanne, L.; Stahl, O.; Stober, Ba.; Stober, Be.; Vollmann, K.; Williams, P. M.

2011-11-01

We present the results from the spectroscopic monitoring of WR 140 (WC7pd + O5.5fc) during its latest periastron passage in 2009 January. The observational campaign consisted of a constructive collaboration between amateur and professional astronomers. It took place at six locations, including Teide Observatory, Observatoire de Haute Provence, Dominion Astrophysical Observatory and Observatoire du Mont Mégantic. WR 140 is known as the archetype of colliding-wind binaries and it has a relatively long period (?8 yr) and high eccentricity (?0.9). We provide updated values for the orbital parameters, new estimates for the WR and O star masses and new constraints on the mass-loss rates and colliding-wind geometry.

Application of the Speed-Duration Relationship to Normalize the Intensity of High-Intensity Interval Training

PubMed Central

Ferguson, Carrie; Wilson, John; Birch, Karen M.; Kemi, Ole J.

2013-01-01

The tolerable duration of continuous high-intensity exercise is determined by the hyperbolic Speed-tolerable duration (S-tLIM) relationship. However, application of the S-tLIM relationship to normalize the intensity of High-Intensity Interval Training (HIIT) has yet to be considered, with this the aim of present study. Subjects completed a ramp-incremental test, and series of 4 constant-speed tests to determine the S-tLIM relationship. A sub-group of subjects (n = 8) then repeated 4 min bouts of exercise at the speeds predicted to induce intolerance at 4 min (WR4), 6 min (WR6) and 8 min (WR8), interspersed with bouts of 4 min recovery, to the point of exercise intolerance (fixed WR HIIT) on different days, with the aim of establishing the work rate that could be sustained for 960 s (i.e. 4×4 min). A sub-group of subjects (n = 6) also completed 4 bouts of exercise interspersed with 4 min recovery, with each bout continued to the point of exercise intolerance (maximal HIIT) to determine the appropriate protocol for maximizing the amount of high-intensity work that can be completed during 4×4 min HIIT. For fixed WR HIIT tLIM of HIIT sessions was 399±81 s for WR4, 892±181 s for WR6 and 1517±346 s for WR8, with total exercise durations all significantly different from each other (P<0.050). For maximal HIIT, there was no difference in tLIM of each of the 4 bouts (Bout 1: 229±27 s; Bout 2: 262±37 s; Bout 3: 235±49 s; Bout 4: 235±53 s; P>0.050). However, there was significantly less high-intensity work completed during bouts 2 (153.5±40. 9 m), 3 (136.9±38.9 m), and 4 (136.7±39.3 m), compared with bout 1 (264.9±58.7 m; P>0.050). These data establish that WR6 provides the appropriate work rate to normalize the intensity of HIIT between subjects. Maximal HIIT provides a protocol which allows the relative contribution of the work rate profile to physiological adaptations to be considered during alternative intensity-matched HIIT protocols. PMID:24244266

The global structure of hot star winds: Constraints from spectropolarimetry

NASA Astrophysics Data System (ADS)

Eversberg, Thomas

2000-11-01

Chapter 1. We present time-series of ultra-high S/N, high resolution spectra of the He II λ 4686 Å emission line in the O4I(n)f supergiant ζ Puppis, the brightest early-type O-star in the sky. These reveal stochastic, variable substructures in the line, which tend to move away from the line-center with time. Similar scaled-up features are well established in the strong winds of Wolf-Rayet stars (the presumed descendants of O stars), where they are explained by outward moving inhomogeneities (e.g., blobs, clumps, shocks) in the winds. If all hot-star winds are clumped like that of ζ Pup, as is plausible, then mass-low rates based on recombination-line intensities will have to be revised downwards. Using a standard `β' velocity law we deduce a value of β = 1.0-1.2 to account for the kinematics of these structures in the wind of ζ Pup. In addition to the small-scale stochastic variations we also find a slow systematic variation of the mean central absorption reversal. Chapter 2. We introduce a new polarimeter unit which, mounted at the Cassegrain focus of any telescope and fiber-connected to a fixed CCD spectrograph, is able to measure all Stokes parameters I, Q, U and V across spectral lines of bright stellar targets and other point sources in a quasi-simultaneous manner. Applying standard reduction techniques for linearly and circularly polarized light we are able to obtain photon-noise limited line polarization. We briefly outline the technical design of the polarimeter unit and the linear algebraic Mueller calculus for obtaining polarization parameters of any point source. In addition, practical limitations of the optical elements are outlined. We present first results obtained with our spectropolarimeter for four bright, hot-star targets: We confirm previous results for Hα in the bright Be star γ Cas and find linear depolarization features across the emission line complex C III/C IV (λ 5696/λ 5808 Å) of the WR+O binary γ2 Vel. We also find circular line polarization in the strongly magnetic Ap star 53 Cam across its Hα absorption line. No obvious line polarization features are seen across Hα in the variable O star θ1 Ori C above the σ ~ 0.2% instrumental level. Chapter 3. We present low resolution (~6 Å), high signal-to noise spectropolarimetric observations obtained with the new William-Wehlau spectropolarimeter for the apparently brightest Wolf-Rayet star in the sky, the 78.5d WR+O binary γ2 Velorum. Quasi- simultaneous monitoring of all four Stokes parameters I(λ), q(λ), u(λ) and v(λ) was carried out over an interval of 31 nights centered on periastron. All emission lines in our observed wavelength interval (5200-6000 Å) show highly stochastic variations over the whole run. The phase-dependent behavior of the excess emission in the C III λ 5696 line can be related to the wind-wind collision phenomenon. Varying features of Stokes q and u are seen across the strong lines, probably as a result of variable electron scattering of mainly continuum light. The spherical symmetry of the WR wind is thus broken by the presence of the O companion and clumping in the WR wind. Similar features in the extended red wing of the C III λ 5696 emission line remain unexplained. No obvious circular line polarization features are seen across any emission line above the 3σ ~ 0.03% instrumental level.

Predictors of post-partum weight retention in a prospective longitudinal study.

PubMed

Martin, Julia Elizabeth; Hure, Alexis Jayne; Macdonald-Wicks, Lesley; Smith, Roger; Collins, Clare Elizabeth

2014-10-01

Post-partum weight retention (WR) occurs in 60-80% of women with some retaining ≥10 kg with contributing factors reported as pre-pregnancy body mass index (BMI), gestational weight gain (GWG) and breastfeeding. A longitudinal study of pregnancy, with 12-month post-partum follow-up was conducted to determine factors associated with WR. Pregnant women (n = 152) were recruited from the John Hunter Hospital antenatal clinic in New South Wales, Australia. Pre-pregnancy weight was self-reported; weight was measured four times during pregnancy (for GWG) and in the first 12 months post-partum. Infant feeding data were obtained via questionnaires. Breastfeeding was categorised as exclusive, predominant, complementary or not breastfeeding. Linear mixed models tested the predictors of WR, with and without adjustment for potential confounders. Compared with pre-pregnancy weight, 68% of women retained weight at 12 months, median (interquartile range) [4.5 kg (2.1-8.9)]. After adjustment, GWG was positively associated with WR (P < 0.01), but pre-pregnancy weight did not predict WR. For each additional week of any breastfeeding, 0.04 kg less weight was retained. Compared with women who retained weight, those women who did retain had higher rates of exclusive breastfeeding at three months (P < 0.05), but the number of weeks of exclusive breastfeeding failed to predict WR for all women. WR following childbirth is common and associated with GWG, while the number of weeks of 'any' breastfeeding contributed to post-partum weight loss. Whether these factors are modifiable strategies to optimise the weight status of women at this life stage requires further research. © 2012 John Wiley & Sons Ltd.

REVEALING THE ASYMMETRY OF THE WIND OF THE VARIABLE WOLF-RAYET STAR WR1 (HD 4004) THROUGH SPECTROPOLARIZATION

DOE Office of Scientific and Technical Information (OSTI.GOV)

St-Louis, N., E-mail: stlouis@astro.umontreal.ca

In this paper, high quality spectropolarimetric observations of the Wolf-Rayet (WR) star WR1 (HD 4004) obtained with ESPaDOnS at the Canada-France-Hawaii Telescope are presented. All major emission lines present in the spectrum show depolarization in the relative Stokes parameters Q/I and U/I. From the behavior of the amount of line depolarization as a function of line strength, the intrinsic continuum light polarization of WR1 is estimated to be P/I = 0.443% ± 0.028% with an angle of θ = –26.°2. Although such a level of polarization could in principle be caused by a wind flattened by fast rotation, the scenariomore » in which it is a consequence of the presence of corotating interaction regions (CIRs) in the wind is preferred. This is supported by previous photometric and spectroscopic observations showing periodic variations with a period of 16.9 days. This is now the third WR star thought to exhibit CIRs in its wind that is found to have line depolarization. Previous authors have found a strong correlation between line depolarization and the presence of an ejected nebula, which they interpret as a sign that the star has relatively recently reached the WR phase since the nebula are thought to dissipate very fast. In cases where the presence of CIRs in the wind is favored to explain the depolarization across spectral lines, the above-mentioned correlation may indicate that those massive stars have only very recently transited from the previous evolutionary phase to the WR phase.« less

Synthesis of iron composites on nano-pore substrates: identification and its application to removal of cyanide.

PubMed

Do, Si-Hyun; Jo, Young-Hoon; Park, Ho-Dong; Kong, Sung-Ho

2012-11-01

Two types of nano-pore substrates, waste-reclaimed (WR) and soil mineral (SM) with the relatively low density, were modified by the reaction with irons (i.e. Fe(II):Fe(III)=1:2) and the applicability of the modified substrates (i.e. Fe-WR and Fe-SM) on cyanide removal was investigated. Modification (i.e. Fe immobilization on substrate) decreased the BET surface area and PZC of the original substrates while it increased the pore diameter and the cation exchange capacity (CEC) of them. XRD analysis identified that maghemite (γ-Fe(2)O(3)) and iron silicate composite ((Mg, Fe)SiO(3)) existed on Fe-WR, while clinoferrosilite (FeSiO(3)) was identified on Fe-SM. Cyanide adsorption showed that WR adsorbed cyanide more favorably than SM. The adsorption ability of both original substrates was enhanced by the modification, which increased the negative charges of the surfaces. Without the pH adjustment, cyanide was removed as much as 97% by the only application of Fe-WR, but the undesirable transfer to hydrogen cyanide was possible because the pH was dropped to around 7.5. With a constant pH of 12, only 54% of cyanide was adsorbed on Fe-WR. On the other hand, the pH was kept as 12 without adjustment in Fe-WR/H(2)O(2) system and cyanide was effectively removed by not only adsorption but also the catalytic oxidation. The observed first-order rate constant (k(obs)) for cyanide removal were 0.49 (± 0.081) h(-1). Moreover, the more cyanate production with the modified substrates indicated the iron composites, especially maghemite, on substrates had the catalytic property to increase the reactivity of H(2)O(2). Copyright © 2012 Elsevier Ltd. All rights reserved.

[Protective effects of WR2721 on early bone marrow hematopoietic function in mice exposed to 6.5 Gy of (60)Co γ-rays].

PubMed

Deng, Zi-Liang; Zhang, Liu-Zhen; Cong, Yue; Liu, Xiao-Lan; Yu, Zu-Ying; Shan, Ya-Jun; Cui, Yu; Wang, Li-Mei; Xing, Shuang; Cong, Yu-Wen; Luo, Qing-Liang

2014-06-01

The aim of this study was to investigate the effect of WR2721(amifostine) against bone marrow hematopoietic damage of mice exposed to 6.5 Gy of (60)Co-γ ray. A total of 60 C57/BL6J mice was divided into 3 groups:normal group (mice were injected with physiological salt solution), irradiation group (mice were injected with physiologic salt solution before irradiation) and WR2721 group (mice were injected with WR2721 before irradiation). The WBC, neutrophil (Neut), Plt and RBC levels in peripheral blood of 3 group mice were counted within 60 days after irradiation; the bone marrow nuclear cells (BMNC) were counted at 2 and 24 hours after irradiation; the hematopoietic stem/progenitor cell (LK/LSK) level and colony formation capability were detected by flow cytometry at 2 and 24 hours after irradiation. The results indicated that the counts of WBC and neut at 4 and 18 days, Plt at 7-18 days and RBC at 10-30 day after irradiation in WR2721 group were higher than those in irradiation group (P < 0.05); the BMNC, LSK and LK levels obviously increased at 24 hours after irradiation (P < 0.05), the CFU-GEMM, CFU-GM, CFU-MK BFU-E and CFU-E all significantly increased at 2 and 24 hours after irradiation (P < 0.01), as compared with irradiation group. It is concluded that WR2721 can effectively alleviate early hematopoietic damage and promote the fast recovery of peripheral blood cells in mice exposed to γ-ray, suggesting that the WR2721 has significant radioprotective effect on hematopoietic system.

Investigations Concerning Hydrolysis and Stabilization of Antiradiation Compounds

DTIC Science & Technology

1982-01-01

Stability of Unencapsulated WR 2721 31 V. DISCUSSION 35 A. Microencapsulation 35 1. Microspheres 35 2. Microcapsules 35 B. Hydrolytic Stability of...in 1.5 hours at 370C in buffered solutions of pH 1.0 or 3.0. 3^ The more promising microspheres and microcapsules released the WR 2721 within two...hours at pH 7.5 in buffered solutions. 4) Analytical procedures were developed for: "♦ WR 2721 (directly) in microcapsules using an HPLC

The effect of 2-[(aminopropyl)amino] ethanethiol on fission-neutron-induced DNA damage and repair.

PubMed Central

Grdina, D. J.; Sigdestad, C. P.; Dale, P. J.; Perrin, J. M.

1989-01-01

The effect(s) of the radioprotector 2-[(aminopropyl)amino] ethanethiol (WR 1065) on fission-neutron-induced DNA damage and repair in V79 Chinese hamster cells was determined by using a neutral filter elution procedure (pH 7.2). When required, WR1065, at a final working concentration of 4 mM, was added to the culture medium, either 30 min before and during irradiation with fission spectrum neutrons (beam energy of 0.85 MeV) from the JANUS research reactor, or for selected intervals of time following exposure. The frequency of neutron-induced DNA strand breaks as measured by neutral elution as a function of dose equalled that observed for 60Co gamma-ray-induced damage (relative biological effectiveness of one). In contrast to the protective effect exhibited by WR1065 in reducing 60Co-induced DNA damage, WR1065 was ineffective in reducing or protecting against induction of DNA strand breaks by JANUS neutrons. The kinetics of DNA double-strand rejoining were measured following neutron irradiation. In the absence of WR1065, considerable DNA degradation by cellular enzymes was observed. This process was inhibited when WR1065 was present. These results indicate that, under the conditions used, the quality (i.e. nature), rather than quantity, of DNA lesions (measured by neutral elution) formed by neutrons was significantly different from that formed by gamma-rays. PMID:2667608

Highly reliable wind-rolling triboelectric nanogenerator operating in a wide wind speed range

PubMed Central

Yong, Hyungseok; Chung, Jihoon; Choi, Dukhyun; Jung, Daewoong; Cho, Minhaeng; Lee, Sangmin

2016-01-01

Triboelectric nanogenerators are aspiring energy harvesting methods that generate electricity from the triboelectric effect and electrostatic induction. This study demonstrates the harvesting of wind energy by a wind-rolling triboelectric nanogenerator (WR-TENG). The WR-TENG generates electricity from wind as a lightweight dielectric sphere rotates along the vortex whistle substrate. Increasing the kinetic energy of a dielectric converted from the wind energy is a key factor in fabricating an efficient WR-TENG. Computation fluid dynamics (CFD) analysis is introduced to estimate the precise movements of wind flow and to create a vortex flow by adjusting the parameters of the vortex whistle shape to optimize the design parameters to increase the kinetic energy conversion rate. WR-TENG can be utilized as both a self-powered wind velocity sensor and a wind energy harvester. A single unit of WR-TENG produces open-circuit voltage of 11.2 V and closed-circuit current of 1.86 μA. Additionally, findings reveal that the electrical power is enhanced through multiple electrode patterns in a single device and by increasing the number of dielectric spheres inside WR-TENG. The wind-rolling TENG is a novel approach for a sustainable wind-driven TENG that is sensitive and reliable to wind flows to harvest wasted wind energy in the near future. PMID:27653976

A model for the global Wolf-Rayet population of the Milky Way

NASA Astrophysics Data System (ADS)

Rosslowe, Christopher K.; Crowther, Paul A.

2013-06-01

Prompted by the rapidly increasing discovery rate of Galactic Wolf-Rayet stars, we have produced a new near-IR absolute magnitude-spectral subtype calibration from Wolf-Rayet stars at known distances (mostly via cluster membership). We combine this with the relative distribution of WR subtypes for the inner disk, solar circle, and outer disk to model the global WR population in the Milky Way. We adopt the observed vertical scale height of known WR stars plus the measured spatial distribution of dust to produce an expected variation in apparent near-IR magnitudes, of relevance to future spectroscopic surveys. Finally, we use our model apparent magnitude distribution to quantify the total Galactic WR population, and compare this total to expectations from various star formation rate indicators.

Behavioral toxicity of selected radioprotectors

NASA Astrophysics Data System (ADS)

Landauer, M. R.; Davis, H. D.; Kumar, K. S.; Weiss, J. F.

1992-10-01

Effective radioprotection with minimal behavioral disruption is essential for the selection of protective agents to be used in manned spaceflight. This overview summarizes the studies on the behavioral toxicity of selected radioprotectors classified as phosphorothioates (WR-2721, WR-3689), bioactive lipids (16, 16 dimethylprostaglandin E2(DiPGE2), platelet activating factor (PAF), leukotriene C4), and immunomodulators (glucan, synthetic trehalose dicorynomycolate, and interleukin-1). Behavioral toxicity was examined in laboratory mice using a locomotor activity test. For all compounds tested, there was a dose-dependent decrease in locomotor behavior that paralleled the dose-dependent increase in radioprotection. While combinations of radioprotective compounds (DiPGE2 plus WR-2721) increased radioprotection, they also decreased locomotor activity. The central nervous system stimulant, caffeine, was able to mitigate the locomotor decrement produced by WR-3689 or PAF.

The Results of the 2013 Pro-Am Wolf-Rayet Campaign

NASA Astrophysics Data System (ADS)

Aldoretta, E. J.; St-Louis, N.; Richardson, N. D.; Moffat, A. F. J.; Eversberg, T.; Hill, G. M.; World-Wide WR Pro-Am Campaign Team

Professional and amateur astronomers around the world contributed to a 4-month long campaign in 2013, mainly in spectroscopy but also in photometry, interferometry and polarimetry, to observe the first 3 Wolf-Rayet stars discovered: WR 134 (WN6b), WR 135 (WC8) and WR 137 (WC7pd+O9). Each of these stars are interesting in their own way, showing a variety of stellar wind structures. The spectroscopic data from this campaign were reduced and analyzed for WR 134 in order to better understand its behavior and long-term periodicity in the context of CIRs in the wind. We will be presenting the results of these spectroscopic data, which include the confirmation of the CIR variability and a time-coherency of ˜ 40 days (half-life of ˜ 20 days).

What is the role played by organic matter fractions from different sieve-size particles in the development of soil water repellency? A case study using analytical pyrolysis.

NASA Astrophysics Data System (ADS)

Jiménez-Morillo, Nicasio T.; González-Pérez, José A.; González-Vila, Francisco J.; Zavala, Lorena M.; Jordán, Antonio; Jiménez-González, Marco A.

2014-05-01

1. INTRODUCTION It is known that soil water repellency (WR) is induced by organic substances covering the surface of minerals particles and aggregates or present as interstitial substances in the soil matrix. It has also been suggested that the persistence of WR is largely conditioned by specific chemical characteristics of soil organic matter (SOM). Most of these substances are abundant in ecosystems and are released into soils as exudates of roots, organic residues in decomposition, or secretions by fungi and other microorganisms. Soil free lipids correspond to a diverse collection of hydrophobic substances including complex substances as sterols, terpenes, polynuclear hydrocarbons, chlorophylls, fatty acids, waxes, and resins. Some of these organic substances, responsible of soil water repellency may be studied using analytical pyrolisis (de la Rosa et al., 2011; González-Pérez et al., 2011). This research aims to study the relation between soil WR and SOM quantity and quality, assessing the impact of organic fractions and its distribution in soil particles of different size on soil WR from sandy soils. 2. METHODS Soil samples were collected under selected species growing in sandy soils from the Doñana National Park (SW Spain), cork oak (Quercus suber, QS), eagle fern (Pteridium aquilinum, PA), pine (Pinus pinea, PP) and rockrose (Halimium halimifolium, HH). Soil WR and physical chemical characteristics including SOM content were assessed in fine earth soil samples (< 2mm) and in soil sieve fractions (1-2, 0.25-1, 0.05-0.25 and <0.05 mm). The composition of common hydrophobic substances present in SOM (n-alkane/alkene pairs and n-alkanoic acids) was assessed by analytical pyrolysis. Analytical pyrolysis techniques do not need a pre-treatment, is fast and easily reproducible 3. RESULTS The severity of soil WR (determined using the WDPT test) may be ordered according to the sequence QS>PA>PP>HH. A positive correlation was observed between WR from each sieve size fraction and SOM content. The most severe WR was detected in QS for all sieve size fractions, followed by the finer fractions form PA, PP and HH samples, which that also shows the highest SOM content, ranging between 20.9% (PP) and 46.9% (QS). Coarser soil fractions (1-2 mm) under PA, PP and HH showed the highest long-chain-even C numbered fatty acids (LCE-FA) in the order PP>PA>HH. No fatty acids were detected neither in sieve fractions 0.25-1, 0.05-0.25 and <0.05 mm from HH samples nor in PA and PP (0.25-1 mm samples). A significant relation was observed between SOM content and severity of soil WR in QS samples and finer fractions of other samples, which is in agreement with previous findings (GOrdillo-Rivero et al., 2013; Jordán et al., 2011). In contrast, 1-2 mm sieve fractions from PP, PA and HH soils showed high severity of soil WR and relatively low SOM contents. This could be explained by a low degree of evolution of organic residues with higher alkane/alkene CPI values and to the presence of a higher diversity of fatty acid structures. These results suggest that soil WR appears as a consequence of lipid compounds in soil. Some similarities were found in the organic molecular assemblages in PA and PP samples, suggesting a fingerprint of pine residues in PA samples, resulting from ancient pine forests. This finding may be also explained by the existence of exogenous organic inputs associated to fine soil particles from border areas of pine forests. REFERENCES de la Rosa, J.M., González-Pérez, J.A., González-Vila, F.J., Knicker, H., Araújo, M.F. 2011. Characterization of wildfire effects on soil organic matter using analytical pyrolysis. Geoderma 191, 24-30. González-Pérez, J.A., González-Vila, F.J., Arias, M.E., Rodríguez, J., de la Rosa, J.M., Marañón, T., Clemente, L. 2011. Geochemical and ecological significance of soil lipids under Rhododendron ponticum stands. Environmental Chemistry Letters 9, 453-464. Gordillo-Rivero, A.J., García-Moreno, J., Jordán, A., Zavala, L.M. 2013. Monitoring fire impacts in soil water repellency and structure stability during 6 years. Flamma 4, 71-75. Jordán, A., Zavala, L.M., Mataix-Solera, J., Nava, A.L., Alanís, N. 2011. Effect of fire severity on water repellency and aggregate stability on Mexican volcanic soils. Catena 84, 136-147.

The Distribution of Massive Stars in M101

NASA Astrophysics Data System (ADS)

Bibby, J.; Shara, M.; Zurek, D.; Crowther, P. A.; Moffat, A. F. J.; Drissen, L.; Wilde, M.

75 WR stars and 164 RSGs are identified in a single WFC3 pointing of our M101 survey. We find that within it's large star-forming complex NGC 5462 WR stars are preferentially located in the core whilst RSGs are found in the halo, suggesting two bursts of star-formation. A review of our WR candidates reveals that only ˜30% are detected in the archival broad-band ACS imaging whilst only ˜50% are associated with HII regions.

Ring nebulae around Wolf-Rayet stars in M33

NASA Technical Reports Server (NTRS)

Drissen, Laurent; Shara, Michael M.; Moffat, Anthony F. J.

1991-01-01

Results of a systematic search for H II ring nebulae surrounding Wolf-Rayet (WR) stars in M33 are presented. Eleven objects are found to be good candidates, while eight others are classified as possible WR ring nebulae. The WR rings in M33 are larger on average than their Galactic counterparts, but the H-alpha luminosity of most of them is comparable to the bright Galactic wind-blown bubbles. The rings are associated with WC as well as with WN stars.

AFRRI (Armed Forces Radiobiology Research Institute) Reports, October-December 1985.

DTIC Science & Technology

1985-01-01

ability of WR-2721 to mitigate the early performance decrement ( PD ) produced by ionizing radiation. In the first study, rats trained on the accelerod motor...occur, (3) WR-2721 does not protect ś- for radiation-induced PD , and (4) WR-2721 combined with radiation disrupts performance more severely than either...interest is the decrement in performance ( PD ) that occurs 0033-7387/85 $3.00 2 Copyfht 0 1ř by Academic Pmrt Inc. AN fthts a" monaduction may form mvnud

Prophylaxis of Plasmodium falciparum Infection in a Human Challenge Model with WR 238605, a New 8-Aminoquinoline Antimalarial

PubMed Central

Brueckner, Ralf P.; Coster, Trinka; Wesche, David L.; Shmuklarsky, Moshe; Schuster, Brian G.

1998-01-01

The prophylactic efficacy of WR 238605, a primaquine analog, was studied with a human Plasmodium falciparum challenge model. A single oral dose of 600 mg, administered 1 day prior to challenge, successfully protected three of four subjects. The fourth subject developed mild, oligosymptomatic malaria on day 31, with drug concentrations one-half of those in the protected individuals. WR 238605 appears to be a promising prophylactic drug for P. falciparum malaria. PMID:9593172

76 FR 50254 - Notice of Lodging of Consent Decree Under the Comprehensive Environmental Response, Compensation...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-12

..., 2011, a proposed Consent Decree in United States and Commonwealth of Massachusetts v. BIM Investment... Healthcare Group LP, W.R. Grace & Co.-Conn., BIM Investment Corporation, and Shaffer Realty Nominee Trust.... BIM Investment Corp. et al., D.J. Ref. No. 90-11-3-09667/1. During the public comment period, the...

HST FGS1R Results On the Association Between Binary Wolf-Rayet Stars and Non-Thermal Radio Emission

NASA Astrophysics Data System (ADS)

Wallace, D. J.; Gies, D. R.; Nelan, E.; Leitherer, C.

2000-12-01

Two separate models have been proposed to explain the non-thermal emission detected in some Wolf-Rayet (WR) stars. In models based on single WR stars, this emission is proposed to arise via synchrotron radiative processes in the outer (intrinsically unstable) WR wind (e.g. White & Chen 1995). In models based on WR + O systems, this non-thermal radio emission is suggested to arise from the WR wind colliding with the wind of a companion (e.g. Williams et al. 1990). In order to be observed, the colliding winds region is believed to occur in wide binaries where the interaction zone is outside the WR radio photosphere (≈30 AU based on spherically symmetric uniform wind models). HST FGS1R observations of 9 non-thermal and 9, as a control group, purely thermal radio emitting stars attempted to verify the theory that this non-thermal emission is always a result of binary interactions. If the binary model is correct, then most or all of our non-thermal targets should have companions with projected separations of 0.01″

Free Radicals Generated by Ionizing Radiation Signal Nuclear Translocation of p53

NASA Technical Reports Server (NTRS)

Martinez, J. D.; Pennington, M. E.; Craven, M. T.; Warters, R. L.

1997-01-01

The p53 tumor suppressor is a transcription factor that regulates several pathways, which function collectively to maintain the integrity of the genome. Nuclear localization is critical for wild-type function. However, the signals that regulate subcellular localization of p53 have not been identified. Here, we examine the effect of ionizing radiation on the subcellular localization of p53 in two cell lines in which p63 is normally sequestered in the cytoplasm and found that ionizing radiation caused a biphasic translocation response. p53 entered the nucleus 1-2 hours postirradiation (early response), subsequently emerged from the nucleus, and then again entered the nucleus 12-24 hours after the cells had been irradiated (delayed response). These changes in subcellular localization could be completely blocked by the free radical scavenger, WR1065. By comparison, two DNA-damaging agents that do not generate free radicals, mitomycin C and doxorubicin, caused translocation only after 12-24 h of exposure to the drugs, and this effect could not be inhibited by WR1065. Hence, although all three DNA-damaging agents induced relocalization of p53 to the nucleus, only the translocation caused by radiation was sensitive to free radical scavenging. We suggest that the free radicals generated by ionizing radiation can signal p53 translocation to the nucleus.

Pathoproteomics of testicular tissue deficient in the GARP component VPS54: the wobbler mouse model of globozoospermia.

PubMed

Jockusch, Harald; Holland, Ashling; Staunton, Lisa; Schmitt-John, Thomas; Heimann, Peter; Dowling, Paul; Ohlendieck, Kay

2014-04-01

In human globozoospermia, round-headed spermatozoa lack an acrosome and therefore cannot properly interact with oocytes. In the wobbler (WR) mouse, an L967Q missense mutation in the vesicular protein-sorting factor VPS54 causes motor neuron degeneration and globozoospermia. Although electron microscopy of WR testis shows all major components of spermatogenesis, they appear in a deranged morphology that prevents the formation of the acrosome. In order to determine proteome-wide changes, affected testes were analysed by 2D-DIGE and MS. The concentration of 8 proteins was increased and that of 35 proteins decreased as compared to wild type. Mass spectrometric analysis identified proteins with an altered concentration to be associated with metabolite transport, fatty acid metabolism, cellular interactions, microtubule assembly and stress response (chaperones Hsp70-2 and Hsp90α). Minor changes were observed for proteins involved in cell redox homeostasis, cytoskeleton formation, PTMs, detoxification and metabolism. The most dramatically decreased protein in WR testis was identified as fatty acid binding protein FABP3, as confirmed by immunoblot analysis. We conclude that a missense mutation in VPS54, an essential component of the Golgi-associated retrograde protein complex, not only prevents the formation of an acrosome but also initiates a cascade of metabolic abnormalities and a stress reaction. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

The Vast Population of Wolf-Rayet and Red Supergiant Stars in M101. I. Motivation and First Results

NASA Astrophysics Data System (ADS)

Shara, Michael M.; Bibby, Joanne L.; Zurek, David; Crowther, Paul A.; Moffat, Anthony F. J.; Drissen, Laurent

2013-12-01

Assembling a catalog of at least 10,000 Wolf-Rayet (W-R) stars is an essential step in proving (or disproving) that these stars are the progenitors of Type Ib and Type Ic supernovae. To this end, we have used the Hubble Space Telescope (HST) to carry out a deep, He II optical narrowband imaging survey of the ScI spiral galaxy M101. Almost the entire galaxy was imaged with the unprecedented depth and resolution that only the HST affords. Differenced with archival broadband images, the narrowband images allow us to detect much of the W-R star population of M101. We describe the extent of the survey and our images, as well as our data reduction procedures. A detailed broadband-narrowband imaging study of a field east of the center of M101, containing the giant star-forming region NGC 5462, demonstrates our completeness limits, how we find W-R candidates, their properties and spatial distribution, and how we rule out most contaminants. We use the broadband images to locate luminous red supergiant (RSG) candidates. The spatial distributions of the W-R and RSG stars near NGC 5462 are strikingly different. W-R stars dominate the complex core, while RSGs dominate the complex halo. Future papers in this series will describe and catalog more than a thousand W-R and RSG candidates that are detectable in our images, as well as spectra of many of those candidates.

Thermochronometrically constrained anatomy and evolution of a Miocene extensional accommodation zone and tilt domain boundary: The southern Wassuk Range, Nevada

NASA Astrophysics Data System (ADS)

Gorynski, Kyle E.; Stockli, Daniel F.; Douglas Walker, J.

2013-06-01

(AHe) and Zircon (ZHe) (U-Th)/He thermochronometric data from the southern Wassuk Range (WR) coupled with 40Ar/39Ar age data from the overlying tilted Tertiary section are used to constrain the thermal evolution of an extensional accommodation zone and tilt-domain boundary. AHe and ZHe data record two episodes of rapid cooling related to the tectonic exhumation of the WR fault block beginning at ~15 and ~4 Ma. Extension was accommodated through fault-block rotation and variably tilted the southern WR to the west from ~60°-70° in the central WR to ~15°-35° in the southernmost WR and Pine Grove Hills, and minimal tilting in the Anchorite Hills and along the Mina Deflection to the south. Middle Miocene geothermal gradient estimates record heating immediately prior to large-magnitude extension that was likely coeval with the extrusion of the Lincoln Flat andesite at ~14.8 Ma. Geothermal gradients increase from ~19° ± 4°C/km to ≥ 65° ± 20°C/km toward the Mina Deflection, suggesting that it was the focus of Middle Miocene arc magmatism in the upper crust. The decreasing thickness of tilt blocks toward the south resulted from a shallowing brittle/ductile transition zone. Postmagmatic Middle Miocene extension and fault-block advection were focused in the northern and central WR and coincidentally moderated the large lateral thermal gradient within the uppermost crust.

The vast population of Wolf-Rayet and red supergiant stars in M101. I. Motivation and first results

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shara, Michael M.; Bibby, Joanne L.; Zurek, David

Assembling a catalog of at least 10,000 Wolf-Rayet (W-R) stars is an essential step in proving (or disproving) that these stars are the progenitors of Type Ib and Type Ic supernovae. To this end, we have used the Hubble Space Telescope (HST) to carry out a deep, He II optical narrowband imaging survey of the ScI spiral galaxy M101. Almost the entire galaxy was imaged with the unprecedented depth and resolution that only the HST affords. Differenced with archival broadband images, the narrowband images allow us to detect much of the W-R star population of M101. We describe the extentmore » of the survey and our images, as well as our data reduction procedures. A detailed broadband-narrowband imaging study of a field east of the center of M101, containing the giant star-forming region NGC 5462, demonstrates our completeness limits, how we find W-R candidates, their properties and spatial distribution, and how we rule out most contaminants. We use the broadband images to locate luminous red supergiant (RSG) candidates. The spatial distributions of the W-R and RSG stars near NGC 5462 are strikingly different. W-R stars dominate the complex core, while RSGs dominate the complex halo. Future papers in this series will describe and catalog more than a thousand W-R and RSG candidates that are detectable in our images, as well as spectra of many of those candidates.« less

Effects of 8-aminoquinolines on the ultrastructural morphology of Pneumocystis carinii.

PubMed Central

Goheen, M. P.; Bartlett, M. S.; Shaw, M. M.; Queener, S. F.; Smith, J. W.

1993-01-01

Primaquine and other 8-aminoquinolines are effective against Pneumocystis carinii in culture and animal models but the way(s) in which they affect P. carinii are not known. This study used transmission electron microscopy to observe early effects of 8-aminoquinolines on P. carinii grown with human embryonic lung fibroblasts in microcarrier suspension culture. The 8-aminoquinolines evaluated were primaquine and Walter Reed Army Institute for Research (WR) compounds WR6026, WR238605 and WR242511. Samples of P. carinii were taken at 0, 3, 6, 12, 24 and 48 hours from culture flasks containing selected concentrations of the drugs. Time matched samples from a parallel culture without drug served as controls. All the 8-aminoquinolines produced similar morphologic alterations of the internal structure of P. carinii. Initially, dilatation of the nuclear envelopes and membranous arrays arising from the reticular system were observed. Later, more organisms displayed large arrays of smooth membranous material often presenting a concentric membranous pattern. Subsequently, cellular organization was lost resulting in necrosis. At concentrations tested WR242511 appeared to be the most effective, producing alterations in many trophozoites after 6 hours of exposure; WR6026 appeared to be the least effective with some organisms unaffected after 48 hours. The changes observed are consistent with damage to the reticular system of P. carinii, which might be caused by oxidation by the 8-aminoquinolines or their metabolites. Images Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 Figure 7 Figure 8 PMID:8398811

Effects of WR1065 on 6-hydroxydopamine-induced motor imbalance: Possible involvement of oxidative stress and inflammatory cytokines.

PubMed

Kheradmand, Afshin; Nayebi, Alireza M; Jorjani, Masoumeh; Khalifeh, Solmaz; Haddadi, Rasool

2016-08-03

Over production of reactive oxygen species (ROS) is postulated to be the main contributor in degeneration of nigrostriatal dopaminergic neurons. In this study we investigated the effects of WR1065, a free radical scavenger, on motor imbalance, oxidative stress parameters and inflammatory cytokines in CSF and brain of hemi-parkinsonian rats. Lesion of dopaminergic neurons was done by unilateral infusion of 6-hydroxydopamine into the central region of the substentia nigra pars compacta (SNc) to induce hemi-parkinsonism and motor imbalance in rats. WR1065 (20, 40 and 80μg/2μl/rat) was administered three days before 6-OHDA administration. After three weeks behavioral study was performed and then brain and CSF samples were collected to assess tumor necrosis factor (TNFα), interlukin (IL-1β), reduced glutathione (GSH), and malondialdehyde (MDA). WR1065 pre-treatment in rats before receiving 6-OHDA, improved significantly motor impairment and caused reduction of MDA and inflammatory cytokines TNFα and IL-1β levels, while GSH level significantly increased when compared with lesioned rats. Our study indicated that WR1065 could improve 6-OHDA-induced motor imbalance. Furthermore, it decreased lipid peroxidation and inflammatory cytokines and restored the level of GSH up to normal range. We suggest that WR1065 can be proposed as a potential neuroprotective agent in motor impairments of PD. However to prove this hypothesis more clinical trial studies should be done. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Acute kinematic and kinetic adaptations to wearable resistance during vertical jumping.

PubMed

Macadam, Paul; Simperingham, Kim D; Cronin, John B; Couture, Grace; Evison, Chloe

2017-06-01

One variation of vertical jump (VJ) training is resisted or weighted jump training, where wearable resistance (WR) enables jumping to be overloaded in a movement specific manner. A two-way analysis of variance with Bonferroni post hoc contrasts was used to determine the acute changes in VJ performance with differing load magnitudes and load placements. Kinematic and kinetic data were quantified using a force plate and contact mat. Twenty sport active subjects (age: 27.8 ± 3.8 years; body mass (BM): 70.2 ± 12.2 kg; height: 1.74 ± 0.78 m) volunteered to participate in the study. Subjects performed the counter movement jump (CMJ), drop jump (DJ) and pogo jump (PJ) wearing no resistance, 3% or 6% BM affixed to the upper or lower body. The main finding in terms of the landing phase was that the effect of WR was non-significant (P > .05) on peak ground reaction force. With regard to the propulsive phase the main findings were that for both the CMJ and DJ, WR resulted in a significant (P < .05) decrease in jump height (CMJ: -12% to -17%, DJ: -10% to -14%); relative peak power (CMJ: -8% to -17%, DJ: -7% to -10%); and peak velocity (CMJ: -4% to -7%, DJ: -3% to -8%); while PJ reactive strength index was significantly reduced (-15% to -21%) with all WR conditions. Consideration should be given to the inclusion of WR in sports where VJ's are important components as it may provide a novel movement specific training stimulus. Highlights WR of 3 or 6 % BM provided a means to overload the subjects in this study resulting in decreased propulsive power and velocity that lead to a reduced jump height and landing force. Specific strength exercises that closely mimic sporting performance are more likely to optimise transference, therefore WR with light loads of 3-6% body mass (BM)appear a suitable tool for movement specific overload training and maximising transference to sporting performance. Practitioners can safely load their athletes with upper or lower body WR of 3-6% BM without fear of overloading the athletesover and above the landing forces they are typically accustomed too. As a training stimulus it would seem the WR loading provides adequate overload and athletes should focus on velocity of movement to improve power output and jump height i.e. take-off velocity.

The Wolf-Rayet star population in the most massive giant H II regions of M33

NASA Technical Reports Server (NTRS)

Drissen, Laurent; Moffat, Anthony F. J.; Shara, Michael M.

1990-01-01

Narrow-band images of NGC 604, NGC 595, and NGC 592, the most massive giant H II regions (GHRs) in M33 have been obtained, in order to study their Wolf-Rayet content. These images reveal the presence of nine candidates in NGC 604 (seven WN, two WC), 10 in NGC 595 (nine WN, one WC), and two in NGC 592 (two WN). Precise positions and estimated magnitudes are given for the candidates, half of which have so far been confirmed spectroscopically as genuine W-R stars. The flux in the emission lines of all candidates is comparable to that of normal Galactic W-R stars of similar subtype. A few of the putative superluminous W-R stars are shown to be close visual double or multiple stars; their newly estimated luminosities are now more compatible with those of normal W-R stars. NGC 595 seems to be overabundant in W-R stars for its mass compared to other GHRs, while NGC 604 is normal. Factors influencing the W-R/O number ratio in GHRs are discussed: metallicity and age appear to be the most important.

US/UK Loan Account Project Status PMOD477

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stevens, Patrice A.

2012-07-12

The viewgraphs describe the status of PMOD477 for LANL. The meeting will occur at DOE-HQ with NA-11 and Military Applications personnel in attendance. Serves to repatriate material with a balance to zero by December 2012. Phase 1 -- Establish formality of operations for War Reserve (WR): Complete surrogate taskings to A90 through a Materials Channel and perform US/UK lessons learned; Complete the US/UK agreed Quality Acceptance Plan, Materials Plan, Shipping procedure, and establish the formal UK/US point of contacts. Phase 2 -- Metal Manufacture (WR): Process material and store material as electrorefined metal (ER) rings, with initial assay and isotopicmore » analysis, prior to manufacturing. Material is cast into accepted configuration and appropriate acceptance document for each aliquot will be generated. Phase 3 -- Intermediate Material Manufacture, Packaging and Shipping (WR): Continue processing of the material in accepted configuration with appropriate acceptance documentation for each aliquot. Provide an initial tasking of the material owed to UK including appropriate quality acceptance documentation. Phase 4 -- Complete Tasking (WR). Phase 5 -- Residue Processing (Non-WR): Complete processing of residue material and waste into accepted configuration with appropriate acceptance document for disposal.« less

Wolf-Rayet phenomena

NASA Technical Reports Server (NTRS)

Conti, P. S.

1982-01-01

The properties of stars showing Wolf-Rayet phenomena are outlined along with the direction of future work. Emphasis is placed on the characteristics of W-R spectra. Specifically the following topics are covered: the absolute visual magnitudes; the heterogeneity of WN spectra; the existence of transition type spectra and compositions the mass loss rates; and the existence of very luminous and possibly very massive W-R stars. Also, a brief overview of current understanding of the theoretical aspects of stellar evolution and stellar winds and the various scenarios that have been proposed to understand W-R spectra are included.

The Definition of Epstein Barr Virus (EBV)’s Role in HTLV-III Infected USAF Personnel as Related to Disease Progression

DTIC Science & Technology

1988-12-27

were considerably greater than those noted in patients with acute EBV induced infectious mononucleosis (IM), while the antibody levels to early... infectious (WR 1 - 6) (WR 1 only) (WR 1) Controls mononucleosis Oropharyngeat EBV 14/20 (70 ) 6/10 (60 ) 19/30 (63 ) 5/23 (21.7) 17/19 (89.5) Spontaneous... EBV infection in patients with ARC and AIDS. B cell lymphomas containing EBV - DNA are being reported in increased frequency in homosexuals and AIDS

THE ORIGIN AND OPTICAL DEPTH OF IONIZING RADIATION IN THE 'GREEN PEA' GALAXIES

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jaskot, A. E.; Oey, M. S.

2013-04-01

Although Lyman-continuum (LyC) radiation from star-forming galaxies likely drove the reionization of the universe, observations of star-forming galaxies at low redshift generally indicate low LyC escape fractions. However, the extreme [O III]/[O II] ratios of the z = 0.1-0.3 Green Pea galaxies may be due to high escape fractions of ionizing radiation. To analyze the LyC optical depths and ionizing sources of these rare, compact starbursts, we compare nebular photoionization and stellar population models with observed emission lines in the Peas' Sloan Digital Sky Survey (SDSS) spectra. We focus on the six most extreme Green Peas, the galaxies with themore » highest [O III]/[O II] ratios and the best candidates for escaping ionizing radiation. The Balmer line equivalent widths and He I {lambda}3819 emission in the extreme Peas support young ages of 3-5 Myr, and He II {lambda}4686 emission in five extreme Peas signals the presence of hard ionizing sources. Ionization by active galactic nuclei or high-mass X-ray binaries is inconsistent with the Peas' line ratios and ages. Although stacked spectra reveal no Wolf-Rayet (WR) features, we tentatively detect WR features in the SDSS spectra of three extreme Peas. Based on the Peas' ages and line ratios, we find that WR stars, chemically homogeneous O stars, or shocks could produce the observed He II emission. If hot stars are responsible, then the Peas' optical depths are ambiguous. However, accounting for emission from shocks lowers the inferred optical depth and suggests that the Peas may be optically thin. The Peas' ages likely optimize the escape of LyC radiation; they are old enough for supernovae and stellar winds to reshape the interstellar medium, but young enough to possess large numbers of UV-luminous O or WR stars.« less

Vectorization in an oncolytic vaccinia virus of an antibody, a Fab and a scFv against programmed cell death -1 (PD-1) allows their intratumoral delivery and an improved tumor-growth inhibition.

PubMed

Kleinpeter, Patricia; Fend, Laetitia; Thioudellet, Christine; Geist, Michel; Sfrontato, Nathalie; Koerper, Véronique; Fahrner, Catherine; Schmitt, Doris; Gantzer, Murielle; Remy-Ziller, Christelle; Brandely, Renée; Villeval, Dominique; Rittner, Karola; Silvestre, Nathalie; Erbs, Philippe; Zitvogel, Laurence; Quéméneur, Eric; Préville, Xavier; Marchand, Jean-Baptiste

2016-01-01

We report here the successful vectorization of a hamster monoclonal IgG (namely J43) recognizing the murine Programmed cell death-1 (mPD-1) in Western Reserve (WR) oncolytic vaccinia virus. Three forms of mPD-1 binders have been inserted into the virus: whole antibody (mAb), Fragment antigen-binding (Fab) or single-chain variable fragment (scFv). MAb, Fab and scFv were produced and assembled with the expected patterns in supernatants of cells infected by the recombinant viruses. The three purified mPD-1 binders were able to block the binding of mPD-1 ligand to mPD-1 in vitro . Moreover, mAb was detected in tumor and in serum of C57BL/6 mice when the recombinant WR-mAb was injected intratumorally (IT) in B16F10 and MCA 205 tumors. The concentration of circulating mAb detected after IT injection was up to 1,900-fold higher than the level obtained after a subcutaneous (SC) injection (i.e., without tumor) confirming the virus tropism for tumoral cells and/or microenvironment. Moreover, the overall tumoral accumulation of the mAb was higher and lasted longer after IT injection of WR-mAb1, than after IT administration of 10 µg of J43. The IT injection of viruses induced a massive infiltration of immune cells including activated lymphocytes (CD8 + and CD4 + ). Interestingly, in the MCA 205 tumor model, WR-mAb1 and WR-scFv induced a therapeutic control of tumor growth similar to unarmed WR combined to systemically administered J43 and superior to that obtained with an unarmed WR. These results pave the way for next generation of oncolytic vaccinia armed with immunomodulatory therapeutic proteins such as mAbs.

Vectorization in an oncolytic vaccinia virus of an antibody, a Fab and a scFv against programmed cell death -1 (PD-1) allows their intratumoral delivery and an improved tumor-growth inhibition

PubMed Central

Kleinpeter, Patricia; Fend, Laetitia; Thioudellet, Christine; Geist, Michel; Sfrontato, Nathalie; Koerper, Véronique; Fahrner, Catherine; Schmitt, Doris; Gantzer, Murielle; Remy-Ziller, Christelle; Brandely, Renée; Villeval, Dominique; Rittner, Karola; Silvestre, Nathalie; Erbs, Philippe; Zitvogel, Laurence; Quéméneur, Eric; Préville, Xavier; Marchand, Jean-Baptiste

2016-01-01

ABSTRACT We report here the successful vectorization of a hamster monoclonal IgG (namely J43) recognizing the murine Programmed cell death-1 (mPD-1) in Western Reserve (WR) oncolytic vaccinia virus. Three forms of mPD-1 binders have been inserted into the virus: whole antibody (mAb), Fragment antigen-binding (Fab) or single-chain variable fragment (scFv). MAb, Fab and scFv were produced and assembled with the expected patterns in supernatants of cells infected by the recombinant viruses. The three purified mPD-1 binders were able to block the binding of mPD-1 ligand to mPD-1 in vitro. Moreover, mAb was detected in tumor and in serum of C57BL/6 mice when the recombinant WR-mAb was injected intratumorally (IT) in B16F10 and MCA 205 tumors. The concentration of circulating mAb detected after IT injection was up to 1,900-fold higher than the level obtained after a subcutaneous (SC) injection (i.e., without tumor) confirming the virus tropism for tumoral cells and/or microenvironment. Moreover, the overall tumoral accumulation of the mAb was higher and lasted longer after IT injection of WR-mAb1, than after IT administration of 10 µg of J43. The IT injection of viruses induced a massive infiltration of immune cells including activated lymphocytes (CD8+ and CD4+). Interestingly, in the MCA 205 tumor model, WR-mAb1 and WR-scFv induced a therapeutic control of tumor growth similar to unarmed WR combined to systemically administered J43 and superior to that obtained with an unarmed WR. These results pave the way for next generation of oncolytic vaccinia armed with immunomodulatory therapeutic proteins such as mAbs. PMID:27853644

Mild water restriction with or without urea for the longterm treatment of syndrome of inappropriate antidiuretic hormone secretion (SIADH): Can urine osmolality help the choice?

PubMed

Decaux, G; Gankam Kengne, F; Couturier, B; Musch, W; Soupart, A; Vandergheynst, F

2018-02-01

Treatment options for chronic SIADH include water restriction (WR) and urea. The usefulness of urine osmolality to guide the choice of the treatment option is not clearly defined. We hypothesized that urine osmolality can indicate whether treatment with mild water restriction alone could be successful. Retrospective Review of clinical and biochemical (blood and urine) data of patients with chronic SIADH treated for at least one year with mild WR (1.5-2l/day) either with or without urea. Twenty nine patients were included. Nine patients were treated by mild WR. Mean serum sodium (SNa) and mean Uosm were 129±2mEq/l and 274±78mOsm/kgH2O respectively before WR, and increased to 138.5±3mEq/l and 505±87mOsm/kgH 2 O (P<0.001). Eight patients were treated with mild WR and 15g urea daily, the SNa and Uosm before treatment were 127.5±3mEq/l and 340±100mOsm/kgH 2 O respectively and increased to 136.5±1mEq/l and 490±151mOsm/kgH 2 O (P<0.001). Four of the eight patients had a permanent low solute intake which contributed to hyponatremia. Twelve patients needed 30g urea daily combined with mild WR. The SNa and Uosm were respectively 126±2mEq/l and 595±176mOsm/kgH 2 O and increased to 136.5±2mEq/l and 698±157mOsm/kgH 2 O (P<0.05). Uosm increased in most of the treated patients. About 30% of patients could be treated by moderate WR alone. All these patients presented an initial urine osmolality lower than 400mOsm/kgH 2 O. Copyright © 2017. Published by Elsevier B.V.

Biodegradation of aromatic compounds by white rot and ectomycorrhizal fungal species and the accumulation of chlorinated benzoic acid in ectomycorrhizal pine seedlings.

PubMed

Dittmann, Jens; Heyser, Wolfgang; Bücking, Heike

2002-10-01

The capability of different white rot (WR, Heterobasidion annosum, Phanerochaete chrysosporium, Trametes versicolor) and ectomycorrhizal (ECM, Paxillus involutus, Suillus bovinus) fungal species to degrade different aromatic compounds and the absorption of 3-chlorobenzoic acid (3-CBA) by ECM pine seedlings was examined. The effect of aromatic compounds on the fungal biomass development varied considerably and depended on (a) the compound, (b) the external concentration, and (c) the fungal species. The highest effect on the fungal biomass development was observed for 3-CBA. Generally the tolerance of WR fungi against aromatic compounds was higher than that of the biotrophic fungal species. The capability of different fungi to degrade aromatic substances varied between the species but not generally between biotrophic and saprotrophic fungi. The highest degradation capability for aromatic compounds was detected for T. versicolor and H. annosum, whereas for Phanerochaete chrysosporium and the ECM fungi lower degradation rates were found. However, Paxillus involutus and S. bovinus showed comparable degradation rates at low concentrations of benzoic acid and 4-hydroxybenzoic acid. In contrast to liquid cultures, where no biodegradation of 3-CBA by S. bovinus was observed, mycorrhizal pines inoculated with S. bovinus showed a low capability to remove 3-CBA from soil substrates. Additional X-ray microanalytical investigations showed, that 3-CBA supplied to mycorrhizal plants was accumulated in the root cell cytoplasm and is translocated across the endodermis to the shoot of mycorrhizal pine seedlings.

Preclinical and clinical aspects on the use of amifostine as chemoprotector in neuroblastoma patients.

PubMed

Fulda, S; Fichtner, I; Hero, B; Berthold, F

2001-01-01

In several studies in adults, amifostine (WR-2721) and its active metabolite WR-1065 have shown protection against myelo- and nephrotoxicity of chemotherapeutic agents without compromising cytotoxic efficacy to the tumor. In the present study, the effect of amifostine and WR-1065 on neuroblastoma tumor growth and its protective potential for hematotoxicity were investigated. Neither amifostine nor WR-1065 reduced the cytotoxic effect of six drugs commonly used for this tumor when tested on neuroblastoma cells in vitro. In mice carrying human xeno-transplanted neuroblastoma, tumor growth and antitumor activity of chemotherapy were unaffected by amifostine. In addition, hematotoxicity of alkylators was relieved in some cases. In patients with neuroblastoma, amifostine only slightly reduced bone marrow toxicity and was highly emetogenic. Therefore, amifostine warrants further investigation before its widespread clinical use in the treatment of children with neuroblastoma.

VLTI and KI Interferometric Observations of Massive Evolved Stars and Their Dusty Circumstellar Environments

NASA Astrophysics Data System (ADS)

Wallace, Debra J.; Danchi, W. C.; Rajagopal, J.; Chesneau, O.; Lopez, B.; Menut, J.; Monnier, J.; Tuthill, P.; Ireland, M.; Barry, R.; Richardson, L. J.

2007-12-01

Recent aperture-masking and interferometric observations of late-type WC Wolf-Rayet stars strongly support the theory that dust formation in these objects is a result of colliding winds in binary systems. To explore and quantify this possible explanation, we have conducted a high-resolution interferometric survey of late-type massive stars utilizing the VLTI, KI, IOTA, and FGS1r interferometers. We present here the motivation for this study. We also present the first results from the MIDI instrument on the VLTI, and the KI and IOTA observations. Our VLTI study is aimed primarily at resolving and characterizing the dust around the WC9 star WR 85a and the LBV WR 122, both dust-producing but at different phases of massive star evolution. Our IOTA and KI interferometric observations resolve the WR star WR 137 into a dust-producing binary system.

Drug Evaluation in the Plasmodium Falciparum - Aotus Model

DTIC Science & Technology

1994-03-15

falciparum infections. Althogh erythromycin is inactive against chloroquine -resistant falciparum infections, an analogue , azithromycin, is effective in vitro...response to chloroquine , and then expand the evaluation of WR 238605, a primaquine analogue against infections. Each cyopreserved sample was thawed rapidly...confirmedo.4 chloroquine -sensitive p. via -strai-n[as not Infective for unaltered Panamanian Aotus. 14. SUBJECT TERMS 15. NUMBER OF PAGES Malaria

Personalized Learning Instructional Staff Survey Results (Spring 2014). Working Paper WR-1062-BMGF

ERIC Educational Resources Information Center

Siler-Evans, Kyle; Steiner, Elizabeth D.; Hamilton, Laura S.; Pane, John F.

2014-01-01

The purpose of this document is to descriptively summarize instructional staff responses to a survey administered by RAND in 23 personalized learning (PL) schools in Spring 2014. This work was performed at the request of the Bill & Melinda Gates Foundation (BMGF), as part of a multi-year evaluation contract. The 23 schools were selected from a…

Coverage and timing of children's vaccination: an evaluation of the expanded programme on immunisation in The Gambia.

PubMed

Scott, Susana; Odutola, Aderonke; Mackenzie, Grant; Fulford, Tony; Afolabi, Muhammed O; Lowe Jallow, Yamundow; Jasseh, Momodou; Jeffries, David; Dondeh, Bai Lamin; Howie, Stephen R C; D'Alessandro, Umberto

2014-01-01

To evaluate the coverage and timeliness of the Expanded Programme on Immunisation (EPI) in The Gambia. Vaccination data were obtained between January 2005 and December 2012 from the Farafenni Health and Demographic Surveillance System (FHDSS), the Basse Health and Demographic Surveillance System (BHDSS), the Kiang West Demographic surveillance system (KWDSS), a cluster survey in the more urban Western Health Region (WR) and a cross sectional study in four clinics in the semi-urban Greater Banjul area of WR. Kaplan-Meier survival function was used to estimate the proportion vaccinated by age and to assess timeliness to vaccination. BCG vaccine uptake was over 95% in all regions. Coverage of DPT1 ranged from 93.2% in BHDSS to 99.8% in the WR. Coverage decreased with increasing number of DPT doses; DPT3 coverage ranged from 81.7% in BHDSS to 99.0% in WR. Measles vaccination coverage ranged from 83.3% in BHDSS to 97.0% in WR. DPT4 booster coverage was low and ranged from 43.9% in the WR to 82.8% in KWDSS. Across all regions, delaying on previous vaccinations increased the likelihood of being delayed for the subsequent vaccination. The Gambia health system achieves high vaccine coverage in the first year of life. However, there continues to be a delay to vaccination which may impact on the introduction of new vaccines. Examples of effectively functioning EPI programmes such as The Gambia one may well be important models for other low income countries struggling to achieve high routine vaccination coverage.

Germinated Brown Rice Attenuates Atherosclerosis and Vascular Inflammation in Low-Density Lipoprotein Receptor-Knockout Mice.

PubMed

Zhao, Ruozhi; Ghazzawi, Nora; Wu, Jiansu; Le, Khuong; Li, Chunyang; Moghadasian, Mohammed H; Siow, Yaw L; Apea-Bah, Franklin B; Beta, Trust; Yin, Zhengfeng; Shen, Garry X

2018-05-02

The present study investigates the impact of germinated brown rice (GBR) on atherosclerosis and the underlying mechanism in low-density lipoprotein receptor-knockout (LDLr-KO) mice. The intensity of atherosclerosis in aortas of LDLr-KO mice receiving diet supplemented with 60% GBR (weight/weight) was significantly less than that in mice fed with 60% white rice (WR) or control diet ( p < 0.05); all diets contained 0.06% cholesterol. WR or GBR diet did not significantly alter plasma total or LDL-cholesterol, fecal sterols, or glucose, or the activities of antioxidant enzymes, compared to the control diet. The adhesion of monocytes to aortas from LDLr-KO mice fed with WR diet was significantly more than that from mice receiving the control diet ( p < 0.01). GBR diet decreased monocyte adhesion to aortas compared to WR diet ( p < 0.01). GBR diet also reduced the levels of plasminogen activator inhibitor-1 (PAI-1), monocyte chemotactic protein-1 (MCP-1), and tumor necrosis factor-α (TNF-α) in plasma, and the abundances of MCP-1, PAI-1, TNF-α, intracellular cell adhesion molecule-1, toll-like receptor-4, PAI-1, LDLr-like protein, and urokinase plasminogen activator and its receptor in aortas or hearts from LDLr-KO mice in comparison to the WR diet ( p < 0.05, 0.01, respectively). The findings suggest that GBR administration attenuated atherosclerosis and vascular inflammation in LDLr-KO mice compared to WR. The anti-atherosclerotic effect of GBR in LDLr-KO mice at least in part results from its anti-inflammatory activity.

[A study on the effects of a Mg-deficient diet on blood pressure and various hormonal systems in Wistar rats and spontaneously hypertensive rats].

PubMed

Honda, M; Izumi, Y; Hatano, M

1988-08-20

The influence of a Mg-deficient diet on blood pressure and various hormonal systems was examined in Wistar rats (WR) and spontaneously hypertensive rats (SHR). The WR and SHR were individually divided into 2 groups. The Mg-deficient diet was given to one group, and a Mg-containing diet was given to the other group for 3 weeks. During this experimental period, the body weight, blood pressure, urine volume, blood and urinary electrolytes, plasma steroid hormones, plasma renin activity (PRA), and urinary hormones [kinin, prostaglandin E2 (PGE2), 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha), and noradrenaline] were examined. Although no significant difference in body weight was observed between the Mg-deficient and Mg-containing diet groups in either the WR or SHR (because the experiments were performed in a pair-fed fashion in both kinds of rat), the blood pressure was increased in the Mg-containing diet group but was unchanged in the Mg-deficient diet group. As regards changes in electrolytes, a decreased urinary excretion of Mg and significantly increased urinary excretion of P were observed in the Mg-deficient diet group in both the WR and SHR. Furthermore, decreased levels of serum Mg and P and increased levels of serum Ca were also noted. In the WR group, the urinary excretion of noradrenaline was significantly increased in the Mg-deficient diet group as compared to the Mg-containing diet group. However, the change was reversed in the SHR group. The plasma steroid hormones and PRA were both significantly low in the Mg-deficient diet group in both the WR and SHR. The urinary excretions of PGE2, 6-keto-PGF1 alpha, and kinin showed no significant differences between the two diet groups. The above results indicate that blood pressure is not affected by the Mg-deficient diet in either the WR or SHR, and the possible participation of the sympathetic nervous system in the mechanism of control of blood pressure may differ somewhat between the WR and SHR. In addition, Mg ion was found to play an important role in the biosynthesis of renin and steroid hormones but to have no such significant role in the urinary excretions of kinin, PGE2, and 6-keto-PGF1 alpha.

RED EYES ON WOLF-RAYET STARS: 60 NEW DISCOVERIES VIA INFRARED COLOR SELECTION

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mauerhan, Jon C.; Van Dyk, Schuyler D.; Morris, Patrick W., E-mail: mauerhan@ipac.caltech.edu

We have spectroscopically identified 60 Galactic Wolf-Rayet (WR) stars, including 38 nitrogen types (WN) and 22 carbon types (WC). Using photometry from the Spitzer/GLIMPSE and Two Micron All Sky Survey databases, the new WRs were selected via a method we have established that exploits their unique infrared colors, which is mainly the result of excess radiation generated by free-free scattering within their dense ionized winds. The selection criterion has been refined since the last report, resulting in a WR detection rate of {approx}20% in spectroscopic follow-up of candidates that comprise a broad color space defined by the color distribution ofmore » all known WRs having B > 14 mag. However, there are smaller regions within this color space that yield WRs at a rate of >50% in spectroscopic follow-up. Candidates that are not WRs are mainly Be stars, which is possibly attributable to the physical similarities between the free-free emission parameters of Be disks and WR winds. As an additional selection experiment, the list of WR candidates was cross-correlated with archival X-ray point-source catalogs, which increases the WR detection rate of the broad color space to {approx}40%; 10 new WR X-ray sources have been found in addition to a previously unrecognized X-ray counterpart to a known WR. The extinction values, distances, and Galactocentric radii of all new WRs are calculated using the method of spectroscopic parallax. Although the majority of the new WRs have no obvious association with stellar clusters, two WC8 stars reside in a previously unknown massive-star cluster, in which five OB supergiants were also identified. The new system lies at an estimated distance of {approx}6.1 kpc, near the intersection of the Scutum-Centaurus Arm with the Galaxy's bar. In addition, two WC and four WN stars, all but one of which are X-ray sources, were identified in association with the stellar clusters Danks 1 and 2. A WN9 star has also been associated with the cluster [DBS2003] 179. This work brings the total number of known Galactic WRs to 476, or {approx}7%-8% of the total empirically estimated population. An examination of their Galactic distribution reveals an approximate tracing of the spiral arms and an enhanced WR surface density toward several massive-star formation sites.« less

Red Eyes on Wolf-Rayet Stars: 60 New Discoveries via Infrared Color Selection

NASA Astrophysics Data System (ADS)

Mauerhan, Jon C.; Van Dyk, Schuyler D.; Morris, Patrick W.

2011-08-01

We have spectroscopically identified 60 Galactic Wolf-Rayet (WR) stars, including 38 nitrogen types (WN) and 22 carbon types (WC). Using photometry from the Spitzer/GLIMPSE and Two Micron All Sky Survey databases, the new WRs were selected via a method we have established that exploits their unique infrared colors, which is mainly the result of excess radiation generated by free-free scattering within their dense ionized winds. The selection criterion has been refined since the last report, resulting in a WR detection rate of ≈20% in spectroscopic follow-up of candidates that comprise a broad color space defined by the color distribution of all known WRs having B > 14 mag. However, there are smaller regions within this color space that yield WRs at a rate of >50% in spectroscopic follow-up. Candidates that are not WRs are mainly Be stars, which is possibly attributable to the physical similarities between the free-free emission parameters of Be disks and WR winds. As an additional selection experiment, the list of WR candidates was cross-correlated with archival X-ray point-source catalogs, which increases the WR detection rate of the broad color space to ≈40% 10 new WR X-ray sources have been found in addition to a previously unrecognized X-ray counterpart to a known WR. The extinction values, distances, and Galactocentric radii of all new WRs are calculated using the method of spectroscopic parallax. Although the majority of the new WRs have no obvious association with stellar clusters, two WC8 stars reside in a previously unknown massive-star cluster, in which five OB supergiants were also identified. The new system lies at an estimated distance of ≈6.1 kpc, near the intersection of the Scutum-Centaurus Arm with the Galaxy's bar. In addition, two WC and four WN stars, all but one of which are X-ray sources, were identified in association with the stellar clusters Danks 1 and 2. A WN9 star has also been associated with the cluster [DBS2003] 179. This work brings the total number of known Galactic WRs to 476, or ≈7%-8% of the total empirically estimated population. An examination of their Galactic distribution reveals an approximate tracing of the spiral arms and an enhanced WR surface density toward several massive-star formation sites.

Spatial distribution of soil moisture and hydrophobicity in the immediate period after a grassland fire in Lithuania

NASA Astrophysics Data System (ADS)

Pereira, P.; Pundyte, N.; Vaitkute, D.; Cepanko, V.; Pranskevicius, M.; Ubeda, X.; Mataix-Solera, J.; Cerda, A.

2012-04-01

Fire can affect significantly soil moisture (SM) and water repellency (WR) in the immediate period after the fire due the effect of the temperatures into soil profile and ash. This impact can be very heterogeneous, even in small distances, due to different conditions of combustion (e.g. fuel and soil moisture, fuel amount and type, distribution and connection, and geomorphological variables as aspect and slope) that influences fire temperature and severity. The aim of this work it is study the spatial distribution of SM and WR in a small plot (400 m2 with a sampling distance of 5 m) immediately after the a low severity grassland fire.. This was made in a burned but also in a control (unburned) plot as reference to can compare. In each plot we analyzed a total of 25 samples. SM was measured gravimetrically and WR with the water drop penetration time test (WDPT). Several interpolation methods were tested in order to identify the best predictor of SM and WR, as the Inverse Distance to a Weight (IDW) (with the power of 1,2,3,4 and 5), Local Polynomial with the first and second polynomial order, Polynomial Regression (PR), Radial Basis Functions (RBF) as Multilog (MTG), Natural Cubic Spline (NCS), Multiquadratic (MTQ), Inverse Multiquadratic (IMTQ) and Thin Plate Spline (TPS) and Ordinary Kriging. Interpolation accuracy was observed with the cross-validation method that is achieved by taking each observation in turn out of the sample and estimating from the remaining ones. The errors produced in each interpolation allowed us to calculate the Root Mean Square Error (RMSE). The best method is the one that showed the lower RMSE. The results showed that on average the SM in the control plot was 13.59 % (±2.83) and WR 2.9 (±1.3) seconds (s). The majority of the soils (88%) were hydrophilic (WDPT <5s). SM in the control plot showed a weak negative relationship with WR (r=-0.33, p<0.10). The coefficient of variation (CV%) of SM was 20.77% and SW of 44.62%. In the burned plot, SM was 14.17% (±2.83) and WR of 151 (±99) seconds (s). All the samples analysed were considered hydrophobic (WDPT >5s). We did not identify significant relationships among the variables (r=0.06, p>0.05) and the CV% was higher in WR (65.85%) than SM (19.96%). Overall we identified no significant changes in SM between plots, which means that fire did not had important implications on soil water content, contrary to observed in WR. The same dynamic was observed in the CV%. Among all tested methods the most accurate to interpolate SM, in the control plot IDW 1 and in the burned plot IDW 2, and this means that fire did not induce important inferences on the spatial distribution of SM. In WR, in the control plot, the best predictor was NCS and in the burned plot was IDW 1 and this means that spatial distribution WR was substantially affected by fire. In this case we observed an increase of the small scale variability in the burned area. Currently we are monitoring this burned area and observing the evaluation of the spatial variability of these two soil properties. It is important to observe their dynamic in the space and time and observe if fire will have medium and long term implications on SM and WR. Discussions about the results will be carried out during the poster session.

Detached dust shell around Wolf-Rayet star WR60-6 in the young stellar cluster VVV CL036

DOE Office of Scientific and Technical Information (OSTI.GOV)

Borissova, J.; Amigo, P.; Kurtev, R.

The discovery of a detached dust shell around the Wolf-Rayet (WR) star WR60-6 in the young stellar cluster VVV CL036 is reported. This shell is uncovered through the Spitzer-MIPS 24 μm image, where it appears brightest, and it is invisible at shorter wavelengths. Using new APEX observations and other data available from the literature, we have estimated some of the shell parameters: the inner and outer radii of 0.15 and 0.90 pc, respectively; the overall systemic velocity of the molecular {sup 12}CO(3 → 2) emission of –45.7 ± 2.3 km s{sup –1}; an expansion velocity of the gas of 16.3more » ± 1 km s{sup –1}; the dust temperature and opacity of 122 ± 12 K and 1.04, respectively; and an age of 2.8 × 10{sup 4} yr. The WR star displays some cyclic variability. The mass computed for the WR60-6 nebula indicates that the material was probably ejected during its previous stages of evolution. In addition, we have identified a bright spot very close to the shell, which can be associated with the Midcourse Space Experiment source G312.13+00.20.« less

Pinwheel Nebula around WR 98a.

PubMed

Monnier; Tuthill; Danchi

1999-11-10

We present the first near-infrared images of the dusty Wolf-Rayet star WR 98a. Aperture-masking interferometry has been utilized to recover images at the diffraction limit of the Keck I telescope, less, similar50 mas at 2.2 µm. Multiepoch observations spanning about 1 yr have resolved the dust shell into a "pinwheel" nebula, the second example of a new class of dust shell first discovered around WR 104 by Tuthill, Monnier, & Danchi. Interpreting the collimated dust outflow in terms of an interacting winds model, the binary orbital parameters and apparent wind speed are derived: a period of 565+/-50 days, a viewing angle of 35&j0;+/-6 degrees from the pole, and a wind speed of 99+/-23 mas yr-1. This period is consistent with a possible approximately 588 day periodicity in the infrared light curve, linking the photometric variation to the binary orbit. Important implications for binary stellar evolution are discussed by identifying WR 104 and WR 98a as members of a class of massive, short-period binaries whose orbits were circularized during a previous red supergiant phase. The current component separation in each system is similar to the diameter of a red supergiant, which indicates that the supergiant phase was likely terminated by Roche lobe overflow, leading to the present Wolf-Rayet stage.

Modelling the colliding-wind spectra of the WC8d+O8-9IV binary CV Ser (WR 113)

NASA Astrophysics Data System (ADS)

Hill, G. M.; Moffat, A. F. J.; St-Louis, N.

2018-03-01

Striking profile variations of the C III λ5696 emission line are visible amongst the high signal-to-noise ratio, moderate resolution spectra of the 29.7 d WC8d+O8-9IV binary CV Ser (WR 113) presented here. Using a significantly revised code, we have modelled these variations assuming the emission originates from the undisturbed WR star wind and a colliding wind shock region that partially wraps around the O star. Changes to the modelling code are chiefly in the form of additional parameters, intended to refine the modelling and facilitate comparison with recent predictions arising from theoretical and hydrodynamical work. This modelling provides measurements of crucial parameters such as the orbital inclination (63.5° ± 2.5°) and thus, together with the RV orbits, the stellar masses (11.7 ± 0.9 M⊙ for the WR star and 33.3 ± 2.0 M⊙ for the O star). We find good agreement with expectations based on theoretical studies and hydrodynamical modelling of colliding wind systems. Moreover, it raises the exciting prospect of providing a reliable method to learn more about WR stellar masses and winds, and for studying the physics of colliding winds in massive stars.

WR 20a Is an Eclipsing Binary: Accurate Determination of Parameters for an Extremely Massive Wolf-Rayet System

NASA Astrophysics Data System (ADS)

Bonanos, A. Z.; Stanek, K. Z.; Udalski, A.; Wyrzykowski, L.; Żebruń, K.; Kubiak, M.; Szymański, M. K.; Szewczyk, O.; Pietrzyński, G.; Soszyński, I.

2004-08-01

We present a high-precision I-band light curve for the Wolf-Rayet binary WR 20a, obtained as a subproject of the Optical Gravitational Lensing Experiment. Rauw et al. have recently presented spectroscopy for this system, strongly suggesting extremely large minimum masses of 70.7+/-4.0 and 68.8+/-3.8 Msolar for the component stars of the system, with the exact values depending strongly on the period of the system. We detect deep eclipses of about 0.4 mag in the light curve of WR 20a, confirming and refining the suspected period of P=3.686 days and deriving an inclination angle of i=74.5d+/-2.0d. Using these photometric data and the radial velocity data of Rauw et al., we derive the masses for the two components of WR 20a to be 83.0+/-5.0 and 82.0+/-5.0 Msolar. Therefore, WR 20a is confirmed to consist of two extremely massive stars and to be the most massive binary known with an accurate mass determination. Based on observations obtained with the 1.3 m Warsaw telescope at Las Campanas Observatory, which is operated by the Carnegie Institute of Washington.

Characterisation and bioactivity of protein-bound polysaccharides from submerged-culture fermentation of Coriolus versicolor Wr-74 and ATCC-20545 strains.

PubMed

Cui, Jian; Goh, Kelvin Kim Tha; Archer, Richard; Singh, Harjinder

2007-05-01

The protein-bound polysaccharides of Coriolus versicolor (CPS) have been reported to stimulate overall immune functions against cancers and various infectious diseases by activating specific cell functions. A New Zealand isolate (Wr-74) and a patented strain (ATCC-20545) of C. versicolor were compared in this study. The fruit bodies of both strains were grown for visual verification. Both strains were grown in submerged-culture using an airlift fermentor with milk permeate as the base medium supplemented with glucose, yeast extract and salt. Metabolic profiles of both strains obtained over 7-day fermentation showed very similar trends in terms of biomass production (8.9-10.6 mg/ml), amounts of extracellular polysaccharide (EPS) from the culture medium (1150-1132 microg/ml), and intracellular polysaccharide (IPS) from the mycelium (80-100 microg/ml). Glucose was the dominant sugar in both EPS and IPS, and the polymers each consisted of three molecular weight fractions ranging from 2 x 10(6) to 3 x 10(3 )Da. Both the EPS and IPS were able to significantly induce cytokine production (interleukin 12 and gamma interferon) in murine splenocytes in vitro. Highest levels of interleukin 12 (291 pg/ml) and gamma interferon (6,159 pg/ml) were obtained from samples containing Wr-74 IPS (0.06 microg/ml) and ATCC 20545 IPS (0.1 microg/ml), respectively. The results indicated that lower levels of EPS and IPS generally resulted in higher immune responses than did higher polymer concentrations.

Polarized light curves illuminate wind geometries in Wolf-Rayet binary stars

NASA Astrophysics Data System (ADS)

Hoffman, Jennifer L.; Fullard, Andrew G.; Nordsieck, Kenneth H.

2018-01-01

Although the majority of massive stars are affected by a companion during the course of their evolution, the role of binary systems in creating supernova and GRB progenitors is not well understood. Binaries containing Wolf-Rayet stars are particularly interesting because they may provide a mechanism for producing the rapid rotation necessary for GRB formation. However, constraining the evolutionary fate of a Wolf-Rayet binary system requires characterizing its mass loss and mass transfer, a difficult prospect in systems whose colliding winds obscure the stars and produce complicated spectral signatures.The technique of spectropolarimetry is ideally suited to studying WR binary systems because it can disentangle spectral components that take different scattering paths through a complex distribution of circumstellar material. In particular, comparing the polarization behavior as a function of orbital phase of the continuum (which arises from the stars) with that of the emission lines (which arise from the interaction region) can provide a detailed view of the wind structures in a WR+O binary and constrain the system’s mass loss and mass transfer properties.We present new continuum and line polarization curves for three WR+O binaries (WR 30, WR 47, and WR 113) obtained with the RSS spectropolarimeter at the Southern African Large Telescope. We use radiative transfer simulations to analyze the polarization curves, and discuss our interpretations in light of current models for V444 Cygni, a well-studied related binary system. Accurately characterizing the structures of the wind collision regions in these massive binaries is key to understanding their evolution and properly accounting for their contribution to the supernova (and possible GRB) progenitor population.

Searching for magnetic fields in 11 Wolf-Rayet stars: Analysis of circular polarization measurements from ESPaDOnS

DOE Office of Scientific and Technical Information (OSTI.GOV)

De la Chevrotière, A.; St-Louis, N.; Moffat, A. F. J.

With recent detections of magnetic fields in some of their progenitor O stars, combined with known strong fields in their possible descendant neutron stars, it is natural to search for magnetic fields in Wolf-Rayet (WR) stars, despite the problems associated with the presence of winds enhanced by an order of magnitude over those of O stars. We continue our search among a sample of 11 bright WR stars following our introductory study in a previous paper of WR6 = EZ CMa using the spectropolarimeter ESPaDOnS at Canada-France-Hawaii Telescope, most of them in all four Stokes parameters. This sample includes sixmore » WN stars and five WC stars encompassing a range of spectral subclasses. Six are medium/long-period binaries and three show corotating interaction regions. We report no definite detections of a magnetic field in the winds in which the lines form (which is about the same distance from the center of the star as it is from the surface of the progenitor O star) for any of the eleven stars. Possible reasons and their implications are discussed. Nonetheless, the data show evidence supporting marginal detections for WR134, WR137, and WR138. According to the Bayesian analysis, the most probable field intensities are B {sub wind} ∼ 200, 130, and 80 G, respectively, with a 95.4% probability that the magnetic fields present in the observable parts of their stellar wind, if stronger, does not exceed B{sub wind}{sup max}∼1900 G, ∼1500 G, and ∼1500 G, respectively. In the case of non-detections, we report an average field strength upper limit of B{sub wind}{sup max}∼500 G.« less

The effect of water restriction on physiological and blood parameters on lactating dairy cows reared under Mediterranean climate.

PubMed

Benatallah, Amel; Ghozlane, Faissal; Marie, Michel

2018-05-31

This study was conducted to evaluate the effect of water restriction (WR) on physiological and blood parameters on lactating dairy cows reared under Mediterranean climate. The trial lasted 16 days preceded by two weeks of adaptation to the experimental condition in spring 2014 on 6 dairy cows in mid-lactation. These cows were watered at will for 4 days (W100) (hydration period), then split into 2 groups, one group has received 25% and the other 50% of water compared to their mean water consumption during the hydration period; then rehydrated for 4 days. Feed intake and physiological parameters: respiratory rate (RR), heart rate (HR) and rectal temperature (RT) were recorded twice a day. Par cons, the blood was collected once a day and analyzed for serum concentration of glucose (Glc), triglycerides (TG), cholesterol (Chol), urea (Ur), creatinine (Crea) and total protein (TP) by enzymatic colorimetric method and cortisol (Cort) by radioimmunoassay (RIA). Total dry matter intake (TDMI) was affected by WR. In fact, a decrease in TDMI was observed in WR groups compared to W100 group (effect, group, period, day, group x day, period x day: p<0.001). Also, WR resulted in a significant increase in RR, HR, RT in WR groups than in W100 group (effect, group: p<0.001). In addition, an increase in the serum concentration of Glc, TG, Chol, Ur, Crea, TP and Cort was noted in WR groups (effect, group, period, day: p<0.001) . This study has shown the ability of cows raised in a Mediterranean climate to cope with different levels of water restriction and thus reach a new equilibrium. As result, the important role of water as a limiting factor for livestock in environments with low water availability.

X-Ray Emission from the Wolf-Rayet Bubble S 308

NASA Technical Reports Server (NTRS)

Toala, J. A.; Guerrero, M. A.; Chu, Y.-H.; Gruendl, R. A.; Arthur, S. J.; Smith, R. C.; Snowden, S. L.

2012-01-01

The Wolf-Rayet (WR) bubble S 308 around the WR star HD 50896 is one of the only two WR bubbles known to possess X-ray emission. We present XMM-Newton observations of three fields of this WR bubble that, in conjunction with an existing observation of its Northwest quadrant (Chu et al. 2003), map most of the nebula. The X-ray emission from S 308 displays a limb-brightened morphology, with a 22' in size central cavity and a shell thickness of approx. 8'. This X-ray shell is confined by the optical shell of ionized material. The spectrum is dominated by the He-like triplets of N VI at approx.0.43 keV and O VII at approx.0.5 keV, and declines towards high energies, with a faint tail up to 1 keV. This spectrum can be described by a two-temperature optically thin plasma emission model (T1 approx.1.1 x 10(exp 6) K, T2 approx.13 x 10(exp 6) K), with a total X-ray luminosity approx.3 x 10(exp 33) erg/s at the assumed distance of 1.8 kpc. Qualitative comparison of the X-ray morphology of S 308 with the results of numerical simulations of wind-blown WR bubbles suggests a progenitor mass of 40 Stellar mass and an age in the WR phase approx.20,000 yrs. The X-ray luminosity predicted by simulatioms including the effects of heat conduction is in agreement with the observations, however, the simulated X-ray spectrum indicates generally hotter gas than is derived from the observations. We suggest that non-equilibrium ionization (NEI) may provide an explanation for this discrepancy.

Formation of methemoglobin and metmyoglobin using 8-aminoquinoline derivatives or sodium nitrite and subsequent reaction with cyanide.

PubMed

Steinhaus, R K; Baskin, S I; Clark, J H; Kirby, S D

1990-10-01

The kinetics of the oxidation of hemoglobin (Hb) and myoglobin (Mb) by sodium nitrite, 8-[(4-amino-1-methylbutyl)amino]-6-methoxy-quinoline diphosphate (primaquine), 6-methoxy-8-(6-diethylaminohexylamino)-4-methyl-quinoline dihydrochloride (WR6026) and 8-[(4-amino-1-methylbutyl)amino]-2,6-dimethoxy-4-methyl- 5-[(3-trifluoromethyl)phenoxy]quinoline succinate (WR238,605) were studied at pH values ranging from 7.4 to 7.6 and at 37 +/- 1 degrees C. The reaction between Hb and primaquine, WR6026 and WR238,605 resulted in precipitation, as did the reaction between Mb and WR238,605. The reaction between nitrite ion (NO2-) and Hb showed a lag period followed by an autocatalytic phase. The data in this study are consistent with and substantiate the proposed mechanism for the Hb-NO2- oxidation reaction. The reaction between Mb and NO2- at higher NO2- concentrations also showed a lag period followed by an autocatalytic period, while at lower NO2- concentrations no lag period was seen. The data suggest a shift in rate constant at these lower NO2- concentrations. The reaction between Mb and both WR6026 and primaquine followed a two-term rate law with oxidant-dependent and -independent terms. Concentration-effect curve data, along with these results, suggest the presence of a catalytic pathway. The rates of formation of cyanomethemoglobin and cyanometmyoglobin complexes from cyanide ion and methemoglobin (MHb) and metmyoglobin (MMb), respectively, were followed in the presence of the heme oxidants. The rate constants were all within a narrow range and suggest that complexation of cyanide by MHb and MMb is not affected by the presence of oxidants.

Effects of White Rice, Brown Rice and Germinated Brown Rice on Antioxidant Status of Type 2 Diabetic Rats

PubMed Central

Imam, Mustapha Umar; Musa, Siti Nor Asma; Azmi, Nur Hanisah; Ismail, Maznah

2012-01-01

Oxidative stress is implicated in the pathogenesis of diabetic complications, and can be increased by diet like white rice (WR). Though brown rice (BR) and germinated brown rice (GBR) have high antioxidant potentials as a result of their bioactive compounds, reports of their effects on oxidative stress-related conditions such as type 2 diabetes are lacking. We hypothesized therefore that if BR and GBR were to improve antioxidant status, they would be better for rice consuming populations instead of the commonly consumed WR that is known to promote oxidative stress. This will then provide further reasons why less consumption of WR should be encouraged. We studied the effects of GBR on antioxidant status in type 2 diabetic rats, induced using a high-fat diet and streptozotocin injection, and also evaluated the effects of WR, BR and GBR on catalase and superoxide dismutase genes. As dietary components, BR and GBR improved glycemia and kidney hydroxyl radical scavenging activities, and prevented the deterioration of total antioxidant status in type 2 diabetic rats. Similarly, GBR preserved liver enzymes, as well as serum creatinine. There seem to be evidence that upregulation of superoxide dismutase gene may likely be an underlying mechanism for antioxidant effects of BR and GBR. Our results provide insight into the effects of different rice types on antioxidant status in type 2 diabetes. The results also suggest that WR consumption, contrary to BR and GBR, may worsen antioxidant status that may lead to more damage by free radicals. From the data so far, the antioxidant effects of BR and GBR are worth studying further especially on a long term to determine their effects on development of oxidative stress-related problems, which WR consumption predisposes to. PMID:23202932

WR 148: identifying the companion of an extreme runaway massive binary*

NASA Astrophysics Data System (ADS)

Munoz, Melissa; Moffat, Anthony F. J.; Hill, Grant M.; Shenar, Tomer; Richardson, Noel D.; Pablo, Herbert; St-Louis, Nicole; Ramiaramanantsoa, Tahina

2017-05-01

WR 148 (HD 197406) is an extreme runaway system considered to be a potential candidate for a short-period (4.3173 d) rare WR + compact object binary. Provided with new high-resolution, high signal-to-noise spectra from the Keck observatory, we determine the orbital parameters for both the primary WR and the secondary, yielding respective projected orbital velocity amplitudes of 88.1 ± 3.8 km s-1 and 79.2 ± 3.1 km s-1 and implying a mass ratio of 1.1 ± 0.1. We then apply the shift-and-add technique to disentangle the spectra and obtain spectra compatible with a WN7ha and an O4-6 star. Considering an orbital inclination of ˜67°, derived from previous polarimetry observations, the system's total mass would be a mere 2-3M_{⊙}, an unprecedented result for a putative massive binary system. However, a system comprising a 37 M_{⊙} secondary (typical mass of an O5V star) and a 33 M_{⊙} primary (given the mass ratio) would infer an inclination of ˜18°. We therefore reconsider the previous methods of deriving the orbital inclination based on time-dependent polarimetry and photometry. While the polarimetric results are inconclusive requiring better data, the photometric results favour low inclinations. Finally, we compute WR 148's space velocity and retrace the runaway's trajectory back to the Galactic plane (GP). With an ejection velocity of 198 ± 27 km s-1 and a travel time of 4.7 ± 0.8 Myr to reach its current location, WR 148 was most likely ejected via dynamical interactions in a young cluster.

Conversion of Sleeve Gastrectomy to Roux-en-Y Gastric Bypass is Effective for Gastro-Oesophageal Reflux Disease but not for Further Weight Loss.

PubMed

Parmar, Chetan D; Mahawar, Kamal K; Boyle, Maureen; Schroeder, Norbert; Balupuri, Shlok; Small, Peter K

2017-07-01

Inadequate weight loss (IWL)/weight regain (WR) and gastro-esophageal reflux disease (GERD), unresponsive to medical management, are two most common indications for conversion of sleeve gastrectomy (SG) to Roux-en-Y gastric bypass (RYGB). This study reports detailed outcomes of conversion of SG to RYGB for these two indications separately. We interrogated our prospectively maintained database to identify patients who underwent a conversion of their SG to RYGB in our unit. Outcomes in patients converted for IWL/WR and those converted for GERD were evaluated separately. We carried out 22 SG to RYGB in our unit between Aug 2012 and April 2015 with a mean follow-up of 16 months. Indication for conversion was GERD in 10/22 (45.5%) patients and IWL/WR in 11/22 (50.0%) patients. Patients undergoing conversion for GERD were significantly lighter (BMI 30.5) than those converted for IWL/WR (BMI 43.3) at the time of conversion. The conversion was very effective for GERD with 100% patients reporting improvement in symptoms, and 80% patients were able to stop their antacid medications. IWL/WR group achieved a further BMI drop of 2.5 points 2 years after surgery (final BMI 40.8) in comparison with 2.0 points BMI drop achieved by the GERD group (final BMI 28.5). This study demonstrates that conversion of SG to RYGB is effective for GERD symptoms but not for further weight loss, which was modest in both groups. Future studies need to examine the best revisional procedure for IWL/WR after SG.

The Distribution of Wolf-Rayet Stars in NGC 6744

NASA Astrophysics Data System (ADS)

Sandford, Emily; Bibby, J. L.; Zurek, D.; Crowther, P.

2013-01-01

We undertake a survey of the Wolf-Rayet population of NGC 6744, a spiral galaxy located at an estimated distance of 11.6 Mpc, in order to determine whether the distribution of this population is consistent with the distributions of various ccSNe subtypes. 242 Wolf-Rayet candidate sources are identified, 40% of which are only detected in narrow-band helium II imaging, not in broad-band imaging. The spatial distribution of WR candidates is compared to the distributions of ccSNe subtype populations in the broad-band B filter and the narrow-band Hα filter. WR stars appear to follow the Type Ic distribution in the faintest 30% of the galaxy in the B image, but follow the Ib or II distribution in the brightest regions, possibly due to the difficulty of detecting WR stars in the brightest regions. WR candidates are found to be closely associated with HII regions; however, the treatment of the residual background strongly affects the distribution, and this result must be investigated further.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Grdina, D.J.; Carnes, B.A.

WR-2721 [S-2-(3-aminopropylamino)ethylphosphorothioic acid] is an effective chemopreventive agent. C57BL {times} BALB/c F{sub 1} female mice, were exposed to a single whole-body dose of 206 cGy from a {sup 60}Co photon source. Those groups treated with VATR-2721 (400 mg/kg) were administered the agent i.p. 30 min prior to irradiation. Over 90% of deaths were determined to be due to tumor involvement. WR-2721 afforded significant protection against life shortening due to radiation-induced tumors of connective tissue and epithelial tissue origins. Subsequent survival time in WR-2721-treated and irradiated animals as compared to matched irradiated-only controls was extended up to 59 days. A singlemore » exposure of animals to VVR-2721 did not affect the cumulative survival curves for unirradiated mice. WR-2721 possesses chemopreventive properties which can be clinically exploited to reduce the risk to therapy-induced secondary cancers in patients who otherwise would have an excellent prognosis for cure and long-term survival.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Grdina, D.J.; Carnes, B.A.

WR-2721 [S-2-(3-aminopropylamino)ethylphosphorothioic acid] is an effective chemopreventive agent. C57BL [times] BALB/c F[sub 1] female mice, were exposed to a single whole-body dose of 206 cGy from a [sup 60]Co photon source. Those groups treated with VATR-2721 (400 mg/kg) were administered the agent i.p. 30 min prior to irradiation. Over 90% of deaths were determined to be due to tumor involvement. WR-2721 afforded significant protection against life shortening due to radiation-induced tumors of connective tissue and epithelial tissue origins. Subsequent survival time in WR-2721-treated and irradiated animals as compared to matched irradiated-only controls was extended up to 59 days. A singlemore » exposure of animals to VVR-2721 did not affect the cumulative survival curves for unirradiated mice. WR-2721 possesses chemopreventive properties which can be clinically exploited to reduce the risk to therapy-induced secondary cancers in patients who otherwise would have an excellent prognosis for cure and long-term survival.« less

Comparative behavioral toxicity of four sulfhydryl radioprotective compounds in mice: Wr2721, cysteamine, diethyldithiocarbamate, and n-acetylcysteine

DOE Office of Scientific and Technical Information (OSTI.GOV)

Landauer, M.R.; Davis, H.D.; Dominitz, J.A.

1988-01-01

A number of sulfhydryl compounds have been shown to protect against ionizing radiation. One of the most effective radioprotectors is S-2(3-aminopropylamino)ethylphosphorothioic acid, also known aas ethiofos, gammaphos, or WR-2721 (Davidson, 1980; Giambarresi and Jacobs, 1987). This drug is currently under clinical investigation for its potential in protecting normal tissue during radiation treatment and chemotherapy (Blumberg et al., 1982; Glover et al., 1988; Yuhas et al., 1980). B-Mercaptoethylamine (MEA, cysteamine) was for years the standard against which the effectiveness of other radioprotectors was judged, but is more toxic than WR-2721 (Giambarresi and Jacobs, 1987). Diethyldithiocarbamate (DDC) and N-acetylcysteine (NAC) are othermore » compounds shown to have radioprotective properties (Milas et al., 1988; Weiss et al., 1984). Studies in a variety of animal species have shown significant behavioral toxicity after administration of WR-2721 (Bogo et al., 1985; Bogo, 1988; Landauer et al., 1987b, 1988).« less

X-ray observations of the colliding wind binary WR 25

NASA Astrophysics Data System (ADS)

Arora, Bharti; Pandey, Jeewan Chandra

2018-04-01

Using the archival data obtained from Chandra and Suzaku spanning over '8 years, we present an analysis of a WN6h+O4f Wolf-Rayet binary, WR 25. The X-ray light curves folded over a period of '208 d in the 0.3 - 10.0 keV energy band showed phase-locked variability where the count rates were found to be maximum near the periastron passage. The X-ray spectra of WR 25 were well explained by a two-temperature plasma model with temperatures of 0.64 ± 0.01 and 2.96 ± 0.05 keV and are consistent with previous results. The orbital phase dependent local hydrogen column density was found to be maximum just after the periastron passage, when the WN type star is in front of the O star. The hard (2.0 - 10.0 keV) X-ray luminosity was linearly dependent on the inverse of binary separation which confirms that WR 25 is a colliding wind binary.

Wolf-Rayet stars as starting points or as endpoints of the evolution of massive stars?

NASA Technical Reports Server (NTRS)

Lamers, H. J. G. L. M.; Maeder, A.; Schmutz, W.; Cassinelli, J. P.

1991-01-01

The paper investigates the evidence for the two interpretations of Wolf-Rayet stars suggested in the literature: (1) massive premain-sequence stars with disks and (2) massive stars which have lost most of their H-rich layers in a stellar wind is investigated. The abundance determinations which are done in two different ways and which lead to different conclusions are discussed. The composition is solar, which would suggest interpretation (1), or the CNO abundances are strongly anomalous, which would suggest interpretation (2). Results from evolutionary calculations, stellar statistics, the existence of Ofpe/WN9 transition stars and W-R stars with evolved companions show overwhelming evidence that W-R stars are not premain-sequence stars but that they are in a late stage of evolution. Moreover, the fact that W-R stars are usually in clear regions of space, whereas massive premain-sequence stars are embedded in ultracompact H II regions also shows that W-R stars are not young premain-sequence stars.

Randomized dose-ranging study of the safety and efficacy of WR 238605 (Tafenoquine) in the prevention of relapse of Plasmodium vivax malaria in Thailand.

PubMed

Walsh, D S; Looareesuwan, S; Wilairatana, P; Heppner, D G; Tang, D B; Brewer, T G; Chokejindachai, W; Viriyavejakul, P; Kyle, D E; Milhous, W K; Schuster, B G; Horton, J; Braitman, D J; Brueckner, R P

1999-10-01

WR 238605 is an 8-aminoquinoline developed for the radical cure of Plasmodium vivax. Forty-four P. vivax-infected patients were randomly assigned to 1 of 4 treatment regimens: 3 groups received a blood schizonticidal dose of chloroquine followed by WR 238605: group A (n=15) received 300 mg daily for 7 days; group B (n=11), 500 mg daily for 3 days, repeated 1 week after the initial dose; group C (n=9), 1 dose of 500 mg. A fourth group (D; n=9) received chloroquine only. Among patients who completed 2-6 months of follow-up (n=23), there was 1 relapse in group B (day 120) and 1 in group C (day 112). Among patients treated with chloroquine only, there were 4 relapses (days 40, 43, 49, and 84). WR 238605 was safe, well tolerated, and effective in preventing P. vivax relapse.

Urease activity as an index for assessing the maturity of cow manure and wheat residue vermicomposts.

PubMed

Sudkolai, Saber Tayebi; Nourbakhsh, Farshid

2017-06-01

The establishment of a reliable index is an essential need to assess the degree of stability and maturity of solid wastes vermicomposts. The objective of this study was to investigate the effects of vermicomposting process on some chemical (pH, EC, OC, TN, lignin and C:N ratio) and biochemical properties of the cow manure (CM) and wheat residue (WR). Results demonstrated that during vermicomposting process of CM and WR urease activity was highly correlated with the time of vermicomposting (r=-0.97 ∗∗ for CM and r=-0.99 ∗∗ for WR), and well able to show the stability of organic waste. The urease activity showed significant correlations with the C:N ratio during the vermicomposting of CM and WR (r=0.89 ∗ and r=0.93 ∗∗ respectively) therefore it can be considered as a reliable indicator for determining the maturity and stability of organic wastes during vermicomposting process. Copyright © 2017. Published by Elsevier Ltd.

Rising Water Storage in the Niger River basin: Clues and Cause

NASA Astrophysics Data System (ADS)

Werth, S.

2016-12-01

Heavily populated west African regions along the Niger River are affected by climate and land cover changes, altering the distribution of water resources. To maintain a reliable water supply in the region, water management authorities require knowledge of hydrological changes at various spatial and temporal scales. Local and regional studies reported rising water tables over the last decades as a consequence of complex responses on land use change in the Sahel zone. The spatial extend of this responses is not well understood, as of yet. Thus, this study provides an in-depth investigation of long-term changes in the water storages of Niger River basin and its sub-regions by analyzing more than a decade of satellite based gravity data from the Gravity Recovery And Climate Change (GRACE) satellites. Soil moisture data from four global hydrological models serve to separate freshwater resources (WR) from GRACE-based terrestrial water storage variations. Surface water variations from a global water storage model and trends from altimetry data were applied to separate the groundwater component from WR trends. Errors of all datasets are taken into account. Trends in WR are positive, except for the tropical Upper Niger with negative trends. For the Niger basin, a rise in GW stocks was detected. On the subbasin scale, GW changes are positive for the Sahelian Middle Niger and the Benue. The findings confirm previous observations of water tables in the Sahel and tropical zones, indicating that reported effects of land use change are relevant on large, i.e. basin and subbasin, scales. Our results have implications for Niger water management strategies. While areas with rising water storage are stocking a comfortable backup to mitigate possible future droughts and to deliver water to remote areas with no access to rivers or reservoirs. Increasing groundwater recharges may be accompanied by a reduction in water quality. This study helps to inform authority's decision to address risks for affected communities.

Using the orbiting companion to trace WR wind structures in the 29d WC8d + O8-9IV binary CV Ser

NASA Astrophysics Data System (ADS)

David-Uraz, Alexandre; Moffat, Anthony F. J.

2011-07-01

We have used continuous, high-precision, broadband visible photometry from the MOST satellite to trace wind structures in the WR component of CV Ser over more than a full orbit. Most of the small-scale light-curve variations are likely due to extinction by clumps along the line of sight to the O companion as it orbits and shines through varying columns of the WR wind. Parallel optical spectroscopy from the Mont Megantic Observatory is used to refine the orbital and wind-collision parameters, as well as to reveal line emission from clumps.

Searching for X-ray variability/periodicity in HD 4004.

NASA Astrophysics Data System (ADS)

Wessolowski, U.; Niedzielski, A.

1996-02-01

The authors present preliminary results of a combined X-ray and optical search for variability/periodicity in HD 4004 (WR 1, WN5-s), an apparently single Wolf-Rayet star known to show radial velocity variations (Lamontagne 1983) and some variability both in photometry (Moffat and Shara 1986) and in optical line profiles (Niedzielski 1995). The two ROSAT PSPC pointed observations of HD 4004 (total effective exposure time of 35 ks) do not provide significant evidence for variability in X-rays. Line profile variations present in newly obtained optical spectra are similar to those of EZ CMa (WR 6, WN5-s+c?), the banner WR+compact companion candidate.

76 FR 68459 - Designation of a Class of Employees for Addition to the Special Exposure Cohort

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-04

... designate a class of employees from W.R. Grace and Company in Curtis Bay, Maryland, as an addition to the... by W.R. Grace and Company in Curtis Bay, Maryland, for the operational period from May 1, 1956...

Wetting properties of fungi mycelium alter soil infiltration and soil water repellency in a γ-sterilized wettable and repellent soil.

PubMed

Chau, Henry Wai; Goh, Yit Kheng; Vujanovic, Vladimir; Si, Bing Cheng

2012-12-01

Soil water repellency (SWR) has a drastic impact on soil quality resulting in reduced infiltration, increased runoff, increased leaching, reduced plant growth, and increased soil erosion. One of the causes of SWR is hydrophobic fungal structures and exudates that change the soil-water relationship. The objective of this study was to determine whether SWR and infiltration could be manipulated through inoculation with fungi. The effect of fungi on SWR was investigated through inoculation of three fungal strains (hydrophilic -Fusarium proliferatum, chrono-amphiphilic -Trichoderma harzianum, and hydrophobic -Alternaria sp.) on a water repellent soil (WR-soil) and a wettable soil (W-soil). The change in SWR and infiltration was assessed by the water repellency index and cumulative infiltration respectively. F. proliferatum decreased the SWR on WR-soil and slightly increased SWR in W-soil, while Alternaria sp. increased SWR in both the W-soil and the WR-soil. Conversely T. harzianum increased the SWR in the W-soil and decreased the SWR in the WR-soil. All strains showed a decrease in infiltration in W-soil, while only the F. proliferatum and T. harzianum strain showed improvement in infiltration in the WR-soil. The ability of fungi to alter the SWR and enmesh soil particles results in changes to the infiltration dynamics in soil. Copyright © 2012 The British Mycological Society. Published by Elsevier Ltd. All rights reserved.

Understanding the Unusual X-Ray Emission Properties of the Massive, Close Binary WR 20a: A High Energy Window into the Stellar Wind Initiation Region

NASA Astrophysics Data System (ADS)

Montes, Gabriela; Ramirez-Ruiz, Enrico; De Colle, Fabio; Strickler, Rachel

2013-11-01

The problem of explaining the X-ray emission properties of the massive, close binary WR 20a is discussed. Located near the cluster core of Westerlund 2, WR 20a is composed of two nearly identical Wolf-Rayet stars of 82 and 83 solar masses orbiting with a period of only 3.7 days. Although Chandra observations were taken during the secondary optical eclipse, the X-ray light curve shows no signs of a flux decrement. In fact, WR 20a appears slightly more X-ray luminous and softer during the optical eclipse, opposite to what has been observed in other binary systems. To aid in our interpretation of the data, we compare with the results of hydrodynamical simulations using the adaptive mesh refinement code Mezcal which includes radiative cooling and a radiative acceleration force term. It is shown that the X-ray emission can be successfully explained in models where the wind-wind collision interface in this system occurs while the outflowing material is still being accelerated. Consequently, WR 20a serves as a critical test-case for how radiatively driven stellar winds are initiated and how they interact. Our models not only procure a robust description of current Chandra data, which cover the orbital phases between 0.3 and 0.6, but also provide detailed predictions over the entire orbit.

The first transition Wolf-Rayet WN/C star in M31

NASA Astrophysics Data System (ADS)

Shara, Michael M.; Mikołajewska, Joanna; Caldwell, Nelson; Iłkiewicz, Krystian; Drozd, Katarzyna; Zurek, David

2016-02-01

Three decades of searches have revealed 154 Wolf-Rayet (WR) stars in M31, with 62 of WC type, 92 of WN type and zero of transition-type WN/C or WC/N. In apparent contrast, about two per cent of the WR stars in the Galaxy, the LMC and M33 simultaneously display strong lines of carbon and nitrogen, I.e. they are transition-type WN/C or WC/N stars. We report here the serendipitous discovery of M31 WR 84-1, the first transition star in M31, located at RA = 00h43m43{^s.}61 Dec. = +41°45'27{^''.}95 (J2000). We present its spectrum, classify it as WN5/WC6, and compare it with other known transition stars. The star is unresolved in Hubble Space Telescope narrow-band and broad-band images, while its spectrum displays strong, narrow emission lines of hydrogen, [N II], [S II] and [O III]; this indicates a nebula surrounding the star. The radial velocity of the nebular lines is consistent with that of gas at the same position in the disc of M31. The metallicity at the 11.8 kpc galactocentric distance of M31 WR 84-1 is approximately solar, consistent with other known transition stars. We suggest that modest numbers of reddened WR stars remain to be found in M31.

Long Working Hours and Work-related Cerebro-cardiovascular Disease in Korea

PubMed Central

CHUNG, Yun Kyung; KWON, Young-jun

2013-01-01

The aim of the present study was to determine a good discriminatory cutoff for long working hours as a surrogate of chronic overload at work, which is associated with the approval of workers’ compensation claims for work-related cerebro-cardiovascular disease (WR-CVD) in Korea. We evaluated weekly working hours for four weeks prior to the onset of disease for all manufacturing industry claimants (N=319) of WR-CVD in 2010. The discrimination of long working hours in predicting approval of worker’s compensation pertaining to WR-CVD was compared across cases. The cutoff was calculated with sensitivity, specificity, and the area under the curve with 95% CI using the receiver operating curve (ROC) method. The cutoff point was thus calculated to be 60.75 h (AUC=0.89, 95% CI [0.84–0.93]), showing a sensitivity value of 65% and specificity of 94%. This is the first study to report that long working hours could be a predictor with good discrimination and high specificity of approval of WR-CVD cases. In Korea, long working hours and widespread chronic overload at work are recognized as a social problem. Our study results suggest an appropriate cutoff for working hours as an indicator of chronic overload for the purpose of approving claims of WR-CVD. Furthermore, these results could contribute to improving the consistency of evaluation. PMID:23892901

Long working hours and work-related cerebro-cardiovascular disease in Korea.

PubMed

Chung, Yun Kyung; Kwon, Young-jun

2013-01-01

The aim of the present study was to determine a good discriminatory cutoff for long working hours as a surrogate of chronic overload at work, which is associated with the approval of workers' compensation claims for work-related cerebro-cardiovascular disease (WR-CVD) in Korea. We evaluated weekly working hours for four weeks prior to the onset of disease for all manufacturing industry claimants (N=319) of WR-CVD in 2010. The discrimination of long working hours in predicting approval of worker's compensation pertaining to WR-CVD was compared across cases. The cutoff was calculated with sensitivity, specificity, and the area under the curve with 95% CI using the receiver operating curve (ROC) method. The cutoff point was thus calculated to be 60.75 h (AUC=0.89, 95% CI [0.84-0.93]), showing a sensitivity value of 65% and specificity of 94%. This is the first study to report that long working hours could be a predictor with good discrimination and high specificity of approval of WR-CVD cases. In Korea, long working hours and widespread chronic overload at work are recognized as a social problem. Our study results suggest an appropriate cutoff for working hours as an indicator of chronic overload for the purpose of approving claims of WR-CVD. Furthermore, these results could contribute to improving the consistency of evaluation.

Effects of atrial fibrillation on myocardial washout rate of thallium-201 on myocardial perfusion single-photon emission computed tomography.

PubMed

Kurisu, Satoshi; Nitta, Kazuhiro; Sumimoto, Yoji; Ikenaga, Hiroki; Ishibashi, Ken; Fukuda, Yukihiro; Kihara, Yasuki

2018-04-20

Myocardial perfusion single-photon emission computed tomography (SPECT) with thallium (Tl)-201 is an established modality for evaluating myocardial ischemia. We assessed the effects of atrial fibrillation (AF) on the myocardial washout rate (WR) of Tl-201 on myocardial perfusion SPECT. A total of 231 patients with no evidence of myocardial ischemia were enrolled retrospectively in this study. Patients were divided into two groups on the basis of the ECG at the time of myocardial perfusion SPECT. The mean myocardial WR of Tl-201 was calculated from the stress and the redistribution Bull's eye maps. There were 34 patients with AF and 197 patients with sinus rhythm. There were no significant differences in clinical variables, except for older age and higher heart rate in patients with AF. Myocardial WR of Tl-201 was significantly lower in patients with AF than those with sinus rhythm (46±12 vs. 51±8%, P=0.03). Multivariate analysis including these factors showed that female sex (β=0.18, P=0.02), AF (β=-0.14 P=0.03), hemoglobin (β=-0.18, P<0.01), and serum creatinine (β=0.24, P<0.01) were determinants of myocardial WR of Tl-201. Our data suggest that AF is associated with reduced myocardial WR of Tl-201 on myocardial perfuison SPECT.

"World Religions" in Introductory Sociology Textbooks

ERIC Educational Resources Information Center

Carroll, Michael P.

2017-01-01

A section on "world religions" (WRs) is now routinely included in the religion chapters of introductory sociology textbooks. Looking carefully at these WR sections, however, two things seem puzzling. The first is that the criteria for defining a WR varies considerably from textbook to textbook; the second is that these WRs sections…

Estimating Nitrogen Loads, BMPs, and Target Loads Exceedance Risks

EPA Science Inventory

The Wabash River (WR) watershed, IN, drains two-thirds of the state’s 92 counties and has primarily agricultural land use. The nutrient and sediment loads of the WR significantly increase loads of the Ohio River ultimately polluting the Gulf of Mexico. The objective of this study...

The Evolution and Physical Parameters of WN3/O3s: A New Type of Wolf–Rayet Star

DOE Office of Scientific and Technical Information (OSTI.GOV)

Neugent, Kathryn F.; Massey, Philip; Hillier, D. John

As part of a search for Wolf–Rayet (WR) stars in the Magellanic Clouds, we have discovered a new type of WR star in the Large Magellanic Cloud (LMC). These stars have both strong emission lines, as well as He ii and Balmer absorption lines and spectroscopically resemble a WN3 and O3V binary pair. However, they are visually too faint to be WN3+O3V binary systems. We have found nine of these WN3/O3s, making up ∼6% of the population of LMC WRs. Using cmfgen, we have successfully modeled their spectra as single stars and have compared the physical parameters with those ofmore » more typical LMC WNs. Their temperatures are around 100,000 K, a bit hotter than the majority of WN stars (by around 10,000 K), though a few hotter WNs are known. The abundances are what you would expect for CNO equilibrium. However, most anomalous are their mass-loss rates, which are more like that of an O-type star than a WN star. While their evolutionary status is uncertain, their low mass-loss rates and wind velocities suggest that they are not products of homogeneous evolution. It is possible instead that these stars represent an intermediate stage between O stars and WNs. Since WN3/O3 stars are unknown in the Milky Way, we suspect that their formation depends upon metallicity, and we are investigating this further by a deep survey in M33, which possesses a metallicity gradient.« less

Mutagencity Testing of WR238605 Succinate

DTIC Science & Technology

1996-05-03

control article have not been determined by the testing facility. The stability of the test or control article under the test conditions has not been...determined by the testing facility and is not included in the final report. Analyses to determine the uniformity, concentration, or stability of the...fraction. Aliquots of the dosing solutions have been retained by MA. The Sponsor has assumed responsibility for the determination of the stability

Stress pre-conditioning with temperature, UV and gamma radiation induces tolerance against phosphine toxicity.

PubMed

Alzahrani, Saad M; Ebert, Paul R

2018-01-01

Phosphine is the only general use fumigant for the protection of stored grain, though its long-term utility is threatened by the emergence of highly phosphine-resistant pests. Given this precarious situation, it is essential to identify factors, such as stress preconditioning, that interfere with the efficacy of phosphine fumigation. We used Caenorhabditis elegans as a model organism to test the effect of pre-exposure to heat and cold shock, UV and gamma irradiation on phosphine potency. Heat shock significantly increased tolerance to phosphine by 3-fold in wild-type nematodes, a process that was dependent on the master regulator of the heat shock response, HSF-1. Heat shock did not, however, increase the resistance of a strain carrying the phosphine resistance mutation, dld-1(wr4), and cold shock did not alter the response to phosphine of either strain. Pretreatment with the LD50 of UV (18 J cm-2) did not alter phosphine tolerance in wild-type nematodes, but the LD50 (33 J cm-2) of the phosphine resistant strain (dld-1(wr4)) doubled the level of resistance. In addition, exposure to a mild dose of gamma radiation (200 Gy) elevated the phosphine tolerance by ~2-fold in both strains.

Searching for Wolf-Rayet Stars Beyond the Local Group

NASA Astrophysics Data System (ADS)

Bibby, J. L.; Shara, M. M.; Crowther, P. A.; Moffat, A. F. J.

2012-12-01

We present preliminary results from our HST/WFC3 F469N narrow-band imaging of the nearby star-forming galaxy M101 in which we search for Wolf-Rayet (WR) stars, possible progenitors of Type Ibc core-collapse supernovae (ccSNe). From analysis of the central pointing of M101 we identify ˜1000 WR candidates from photometric analysis and estimate ˜ 450 using the “blinking” method. From analysis of a sample region we find that 35% of our WR candidates would not be detected in ground-based surveys and 40% of sources are not detected in the HST F435W images, highlighting the importance of high spatial resolution narrow-band imaging.

Timing module for MTCA MCH

NASA Astrophysics Data System (ADS)

Gumiński, M.; Kasprowicz, G.

2016-09-01

White Rabbit is an extension of Precise Time Protocol for synchronous Ethernet networks. Network created with dedicated WR switches enable synchronisation of WR capable devices with 1 ns precision. MicroTCA on the other hand is open standard defining cost efficient shelves capable of housing AMC modules used for data processing. Presented article give further introduction to WR and MTCA standard. The most important aspects of MTCA system are described, with focus on shelf controller and its functionality. Following part describes timing difficulties in MTCA systems and possible solutions. Main section describes extension module for MCH, capable of implementing White Rabbit node and distributing acquired timing to all modules connected to MTCA. Conclusions are given at the end of the article.

Development of Eczema Vaccinatum in Atopic Mouse Models and Efficacy of MVA Vaccination against Lethal Poxviral Infection

PubMed Central

Knitlova, Jarmila; Hajkova, Vera; Voska, Ludek; Elsterova, Jana; Obrova, Barbora; Melkova, Zora

2014-01-01

Smallpox vaccine based on live, replicating vaccinia virus (VACV) is associated with several potentially serious and deadly complications. Consequently, a new generation of vaccine based on non-replicating Modified vaccinia virus Ankara (MVA) has been under clinical development. MVA seems to induce good immune responses in blood tests, but it is impossible to test its efficacy in vivo in human. One of the serious complications of the replicating vaccine is eczema vaccinatum (EV) occurring in individuals with atopic dermatitis (AD), thus excluding them from all preventive vaccination schemes. In this study, we first characterized and compared development of eczema vaccinatum in different mouse strains. Nc/Nga, Balb/c and C57Bl/6J mice were epicutaneously sensitized with ovalbumin (OVA) or saline control to induce signs of atopic dermatitis and subsequently trans-dermally (t.d.) immunized with VACV strain Western Reserve (WR). Large primary lesions occurred in both mock- and OVA-sensitized Nc/Nga mice, while they remained small in Balb/c and C57Bl/6J mice. Satellite lesions developed in both mock- and OVA-sensitized Nc/Nga and in OVA-sensitized Balb/c mice with the rate 40–50%. Presence of mastocytes and eosinophils was the highest in Nc/Nga mice. Consequently, we have chosen Nc/Nga mice as a model of AD/EV and tested efficacy of MVA and Dryvax vaccinations against a lethal intra-nasal (i.n.) challenge with WR, the surrogate of smallpox. Inoculation of MVA intra-muscularly (i.m.) or t.d. resulted in no lesions, while inoculation of Dryvax t.d. yielded large primary and many satellite lesions similar to WR. Eighty three and 92% of mice vaccinated with a single dose of MVA i.m. or t.d., respectively, survived a lethal i.n. challenge with WR without any serious illness, while all Dryvax-vaccinated animals survived. This is the first formal prove of protective immunity against a lethal poxvirus challenge induced by vaccination with MVA in an atopic organism. PMID:25486419

Le Phénomène Wolf-Rayet au Sein des Etoiles chaudes de Populations I et II: Histoire des Vents stellaires et Impact sur la Structure nébulaire circumstellaire

NASA Astrophysics Data System (ADS)

Grosdidier, Yves

2000-12-01

Les spectres des étoiles Wolf-Rayet pop. I (WR) présentent de larges raies en émission dues à des vents stellaires chauds en expansion rapide (vitesse terminale de l'ordre de 1000 km/s). Le modèle standard des étoiles WR reproduit qualitativement le profil général et l'intensité des raies observées. Mais la spectroscopie intensive à moyenne résolution de ces étoiles révèle l'existence de variations stochastiques dans les raies (sous-pics mobiles en accélération échelles de temps: environ 10-100 min.). Ces variations ne sont pas comprises dans le cadre du modèle standard et suggèrent une fragmentation intrinsèque des vents. Cette thèse de doctorat présente une étude de la variabilité des raies spectrales en émission des étoiles WR pop. II; la question de l'impact d'un vent WR fragmenté sur le milieu circumstellaire est aussi étudiée: 1) à partir du suivi spectroscopique intensif des raies CIIIl5696 et CIVl5801/12, nous analysons quantitativement (via le calcul des Spectres de Variance Temporelle) les vents issus de 5 étoiles centrales de nébuleuses planétaires (NP) galactiques présentant le phénomène WR; 2) nous étudions l'impact de la fragmentation des vents issus de deux étoiles WR pop. I sur le milieu circumstellaire via: i) l'imagerie IR (NICMOS2/HST) de WR 137, et ii) l'imagerie H-alpha (WFPC2/HST) et l'interférométrie Fabry-Perot H-alpha (SIS-CFHT) de la nébuleuse M 1-67 (étoile centrale: WR 124). Les principaux résultats sont les suivants: VENTS WR POP. II: (1) Nous démontrons la variabilité spectroscopique intrinsèque des vents issus des noyaux de NP HD 826 ([WC 8]), BD +30 3639 ([WC 9]) et LSS 3169 ([WC 9]), observés durant respectivement 22, 15 et 1 nuits, et rapportons des indications de variabilité pour les noyaux [WC 9] HD 167362 et He 2-142. Les variabilités de HD 826 et BD +30 3639 apparaissent parfois plus soutenues (``bursts'' qui se maintiennent durant plusieurs nuits); (2) La cinématique des sous-pics de BD +30 3639 suggère une anisotropie transitoire de la distribution des fragments dans le vent; (3) Le phénomène WR apparaît purement atmosphérique: la cinématique des sous-pics, les amplitudes et les échelles de temps caractéristiques des variations, ainsi que les accélérations observées sont similaires pour les deux populations. Mais, pour HD 826, une accélération maximale d'environ 70 m/s2 est détectée, valeur significativement plus importante que celles rapportées pour les autres étoiles WR pop. I & II (environ 15 m/s2). La petitesse du rayon de HD 826 en serait la cause; (4) Comme pour les WR pop. I, de grands paramètres (β supérieur ou égal à 3-10) sont requis pour ajuster les accélérations observées avec une loi de vitesse de type beta. La loi beta sous-estime systématiquement les gradients de vitesse au sein de la région de formation de la raie CIIIl5696; (5) Les vents WR pop. II étant fragmentés, l'estimation des taux de perte de masse actuels à partir de méthodes supposant les atmosphères homogènes conduit à une surestimation i) des taux de perte de masse eux-mêmes, et ii) des masses initiales des étoiles avant qu'elles n'entrent dans la phase WR. IMPACT DES VENTS: (1) Au périastre, de la poussière est détectée dans l'environnement de la binaire WC+OB WR 137. La formation de poussières est soit facilitée, soit provoquée par la collision des deux vents chauds; le rôle capital de la fragmentation des vents (fournissant une compression localisée supplémentaire du plasma) est suggéré (2) La nébuleuse M 1-67 affiche une interaction avec le milieu interstellaire (MIS) non-négligeable (``bow-shock''). Les champs de densité et de vitesse sont très perturbés. Ces perturbations sont reliées, d'une part, à l'histoire des vents issus de WR 124 durant sa propre évolution, d'autre part, à l'interaction avec le MIS. Les fonctions de structure des champs de densitéet de vitesse de M 1-67 ne révèlent aucun indice en faveur d'une turbulence au sein de la nébuleuse (3) Des simulations hydrodynamiques 2D réalisées avec le code ZEUS-3D montrent qu'un fragment dense formé près du coeur hydrostatique stellaire ne peut probablement pas, sans adjoindre les effets de bouclier et de confinement radiatifs, atteindre des distances nébulaires.

Ankyrin-B metabolic syndrome combines age-dependent adiposity with pancreatic β cell insufficiency.

PubMed

Lorenzo, Damaris N; Healy, Jane A; Hostettler, Janell; Davis, Jonathan; Yang, Jiayu; Wang, Chao; Hohmeier, Hans Ewald; Zhang, Mingjie; Bennett, Vann

2015-08-03

Rare functional variants of ankyrin-B have been implicated in human disease, including hereditary cardiac arrhythmia and type 2 diabetes (T2D). Here, we developed murine models to evaluate the metabolic consequences of these alterations in vivo. Specifically, we generated knockin mice that express either the human ankyrin-B variant R1788W, which is present in 0.3% of North Americans of mixed European descent and is associated with T2D, or L1622I, which is present in 7.5% of African Americans. Young AnkbR1788W/R1788W mice displayed primary pancreatic β cell insufficiency that was characterized by reduced insulin secretion in response to muscarinic agonists, combined with increased peripheral glucose uptake and concomitantly increased plasma membrane localization of glucose transporter 4 (GLUT4) in skeletal muscle and adipocytes. In contrast, older AnkbR1788W/R1788W and AnkbL1622I/L1622I mice developed increased adiposity, a phenotype that was reproduced in cultured adipocytes, and insulin resistance. GLUT4 trafficking was altered in animals expressing mutant forms of ankyrin-B, and we propose that increased cell surface expression of GLUT4 in skeletal muscle and fatty tissue of AnkbR1788W/R1788W mice leads to the observed age-dependent adiposity. Together, our data suggest that ankyrin-B deficiency results in a metabolic syndrome that combines primary pancreatic β cell insufficiency with peripheral insulin resistance and is directly relevant to the nearly one million North Americans bearing the R1788W ankyrin-B variant.

Evaluation of fly ash in water reduced paving mixtures.

DOT National Transportation Integrated Search

1985-06-01

Fly ash was used to replace 15% of the cement in C3WR and C6WR concrete : paving mixes containing ASTM C494 Type A water reducin9 admixtures. Two Class : C ashes and one Class F ash from Iowa approved sources were examined in each : mix. When Class C...

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lee, H.B.; Wexler, J.P.; Scharf, S.C.

The effect of two antihypertensive agents (captopril and prazosin) and of digoxin on the efficiency of Tc-99m binding to RBCs was evaluated in the rat. RBCs were labeled with Tc-99m in vivo in six groups of rats: I-normotensive controls Wistar rat (WR), II-prazosin treated WR, III-spontaneously hypertensive rat (SHR), IV-prazosin-treated SHR, V-digoxin-treated WR, and VI-captopril-treated WR. The percentage of intravascular Tc-99m bound to RBC (%T) and the percentage of injected dose remaining intravascular 5 min after injection (%i.v.) were determined. Mean %T was 94.2, 83.8, 94.9, 86.1, 79.7, and 93.3 for groups I-VI respectively. Mean %I.V. was 96.4, 74.6, 94.9,more » 79.0, 74.4, and 87.4 for groups I-VI respectively. The findings demonstrate a significant reduction of RBC tagging with Tc-99m in rats treated with prazosin and digoxin but not with captopril. The data suggest a potential interference by patient medication with the performance of blood-pool studies.« less

The evolution of massive stars including mass loss - Presupernova models and explosion

NASA Technical Reports Server (NTRS)

Woosley, S. E.; Langer, Norbert; Weaver, Thomas A.

1993-01-01

The evolution of massive stars of 35, 40, 60, and 85 solar masses is followed through all stages of nuclear burning to the point of Fe core collapse. Critical nuclear reaction and mass-loss rates are varied. Efficient mass loss during the Wolf-Rayet (WR) stage is likely to lead to final masses as small as 4 solar masses. For a reasonable parameterization of the mass loss, there may be convergence of all WR stars, both single and in binaries, to a narrow band of small final masses. Our representative model, a 4.25 solar-mass WR presupernova derived from a 60 solar mass star, is followed through a simulated explosion, and its explosive nucleosynthesis and light curve are determined. Its properties are similar to those observed in Type Ib supernovae. The effects of the initial mass and mass loss on the presupernova structure of small mass WR models is also explored. Important properties of the presupernova star and its explosion can only be obtained by following the complete evolution starting on the main sequence.

Radioprotection by polysaccharides alone and in combination with aminothiols

NASA Astrophysics Data System (ADS)

Patchen, Myra L.; Macvittie, Thomas J.; Solberg, Brian D.; D'Alesandro, Michele M.; Brook, Itzhak

We demonstrated that glucan, a beta-1,3 polysaccharide immunomodulator, enhances survival of mice when administered before radiation exposure. Glucan's prophylactic survival-enhancing effects are mediated by several mechanisms including (1) increasing macrophage-mediated resistance to potentially lethal postirradiation opportunistic infections, (2) increasing the Do of hematopoietic progenitor cells, and (3) accelerating hematopoietic reconstitution. In addition, even when administered shortly after some otherwise lethal doses of radiation, glucan increases survival. Glucan's therapeutic survival-enhancing effects are also mediated through its ability to enhance macrophage function and to accelerate hematopoietic reconstitution; glucan's therapeutic potential, however, is ultimately dependent on the survival of a critical number of hematopoietic stem cells capable of responding to glucan's stimulatory effects. Preirradiation administration of the traditional aminothiol radioprotectants WR-2721 and WR-3689 has been previously demonstrated to be an extremely effective means to increase hematopoietic stem cell survival. Therapeutic glucan treatment administered in combination with preirradiation WR-2721 or WR-3689 treatment synergistically increases both hematopoietic reconstitution and survival. Such combined modality treatments offer new promise in treating acute radiation injury.

Transmission-blocking activity of tafenoquine (WR-238605) and artelinic acid against naturally circulating strains of Plasmodium vivax in Thailand.

PubMed

Ponsa, Narong; Sattabongkot, Jetsumon; Kittayapong, Pattamaporn; Eikarat, Nantana; Coleman, Russell E

2003-11-01

The sporontocidal activity of tafenoquine (WR-238605) and artelinic acid was determined against naturally circulating isolates of Plasmodium vivax in western Thailand. Primaquine was used as a negative control and a dihydroacridine-dione (WR-250547) was used as a positive control. Laboratory-reared Anopheles dirus mosquitoes were infected with P. vivax by allowing mosquitoes to feed on blood (placed in an artificial-membrane feeding apparatus) collected from gametocytemic volunteers reporting to local malaria clinics in Tak province, Thailand. Four days post-infection, mosquitoes were refed on uninfected mice treated 90 minutes earlier with a given drug. Drug activity was determined by assessing oocyst and sporozoite development. Neither primaquine nor artelinic acid affected oocyst or sporozoite development at a dose of 100 mg of base drug/kg of mouse body weight. In contrast, tafenoquine and WR-250547 affected sporogonic development at doses as low as 25.0 and 0.39 mg/kg, respectively. The potential role of these compounds in the prevention of malaria transmission is discussed, as are alternative strategies for the use of transmission-blocking antimalarial drugs.

Search for tb resonances in proton-proton collisions at √s=7 TeV with the ATLAS detector.

PubMed

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Will, J Z; Williams, E; Williams, H H; Willis, W; Willocq, S; Wilson, J A; Wilson, M G; Wilson, A; Wingerter-Seez, I; Winkelmann, S; Winklmeier, F; Wittgen, M; Wolter, M W; Wolters, H; Wong, W C; Wooden, G; Wosiek, B K; Wotschack, J; Woudstra, M J; Wozniak, K W; Wraight, K; Wright, C; Wright, M; Wrona, B; Wu, S L; Wu, X; Wu, Y; Wulf, E; Wunstorf, R; Wynne, B M; Xella, S; Xiao, M; Xie, S; Xie, Y; Xu, C; Xu, D; Xu, G; Yabsley, B; Yacoob, S; Yamada, M; Yamaguchi, H; Yamamoto, A; Yamamoto, K; Yamamoto, S; Yamamura, T; Yamanaka, T; Yamaoka, J; Yamazaki, T; Yamazaki, Y; Yan, Z; Yang, H; Yang, U K; Yang, Y; Yang, Y; Yang, Z; Yanush, S; Yao, Y; Yasu, Y; Ybeles Smit, G V; Ye, J; Ye, S; Yilmaz, M; Yoosoofmiya, R; Yorita, K; Yoshida, R; Young, C; Young, C J; Youssef, S; Yu, D; Yu, J; Yu, J; Yuan, L; Yurkewicz, A; Zabinski, B; Zaets, V G; Zaidan, R; Zaitsev, A M; Zajacova, Z; Zanello, L; Zaytsev, A; Zeitnitz, C; Zeller, M; Zeman, M; Zemla, A; Zendler, C; Zenin, O; Zeniš, T; Zinonos, Z; Zenz, S; Zerwas, D; Zevi Della Porta, G; Zhan, Z; Zhang, D; Zhang, H; Zhang, J; Zhang, X; Zhang, Z; Zhao, L; Zhao, T; Zhao, Z; Zhemchugov, A; Zheng, S; Zhong, J; Zhou, B; Zhou, N; Zhou, Y; Zhu, C G; Zhu, H; Zhu, J; Zhu, Y; Zhuang, X; Zhuravlov, V; Zieminska, D; Zimmermann, R; Zimmermann, S; Zimmermann, S; Ziolkowski, M; Zitoun, R; Zivković, L; Zmouchko, V V; Zobernig, G; Zoccoli, A; Zur Nedden, M; Zutshi, V; Zwalinski, L

2012-08-24

This Letter presents a search for tb resonances in 1.04 fb(-1) of LHC proton-proton collision data collected by the ATLAS detector at a center-of-mass energy of 7 TeV. Events with a lepton, missing transverse momentum, and two jets are selected and the invariant mass of the corresponding final state is reconstructed. The search exploits the shape of the tb invariant mass distribution compared to the expected standard model backgrounds. The model of a right-handed W(R)' with standard model-like couplings is chosen as the benchmark model for this search. No statistically significant excess of events is observed in the data, and upper limits on the cross section times the branching ratio of W(R)' resonances at 95% C.L. lie in the range of 6.1-1.0 pb for W(R)' masses ranging from 0.5 to 2.0 TeV. These limits are translated into a lower bound on the allowed right-handed W(R)' mass, giving m(W(R)'))>1.13 TeV at 95% C.L.

Hot Gas in the Wolf-Rayet Nebula NGC 3199

NASA Astrophysics Data System (ADS)

Toalá, J. A.; Marston, A. P.; Guerrero, M. A.; Chu, Y.-H.; Gruendl, R. A.

2017-09-01

The Wolf-Rayet (WR) nebula NGC 3199 has been suggested to be a bow shock around its central star, WR 18, which is presumably a runaway star, because optical images of the nebula show a dominating arc of emission southwest of the star. We present the XMM-Newton detection of extended X-ray emission from NGC 3199, unveiling the powerful effect of the fast wind from WR 18. The X-ray emission is brighter in the region southeast of the star and an analysis of the spectral properties of the X-ray emission reveals abundance variations: (I) regions close to the optical arc present nitrogen-rich gas enhanced by the stellar wind from WR 18 and (II) gas at the eastern region exhibits abundances close to those reported for the nebular abundances derived from optical studies, which is a signature of an efficient mixing of the nebular material with the stellar wind. The dominant plasma temperature and electron density are estimated to be T ≈ 1.2 × 106 K and n e = 0.3 cm-3 with an X-ray luminosity in the 0.3-3.0 keV energy range of L X = 2.6 × 1034 erg s-1. Combined with information derived from Herschel and the recent Gaia first data release, we conclude that WR 18 is not a runaway star and that the formation, chemical variations, and the shape of NGC 3199 depend on the initial configuration of the interstellar medium.

123I-BMIPP delayed scintigraphic imaging in patients with chronic heart failure.

PubMed

Kida, Keisuke; Akashi, Yoshihiro J; Yoneyama, Kihei; Shimokawa, Mitsuhiro; Musha, Haruki

2008-11-01

The objective of the present study was to clarify the ability of 123I-beta-methyl-iodophenylpentadecanoic acid (123I-BMIPP) to evaluate the heart-to-mediastinum (H/M) ratio and myocardial global washout rate (WR) in patients with chronic heart failure (CHF). The severity of CHF was evaluated on the basis of the New York Heart Association (NYHA) classification. Twenty patients with CHF (13 with idiopathic dilated cardiomyopathy and 7 with ischemic cardiomyopathy) and 11 age-matched controls underwent myocardial radionuclide imaging. Scintigraphic images were obtained from each participant at the early (30 min following radio-isotope injection) and late (4 h) phases using 123I-BMIPP. The H/M ratio and WR were calculated from planar images. Concentrations of plasma brain natriuretic peptide (BNP) were measured prior to the scintigraphic study. The 123I-BMIPP uptake of early H/M and global WR did not significantly differ among groups, but uptake of delayed H/M was significantly lower in patients with NYHA class III than in controls (control 2.47 +/- 0.39; class III 1.78 +/- 0.28, P < 0.05). The uptake of delayed H/M and global WR correlated with plasma log BNP in all participants (r = -0.38, P < 0.05; 0.43, P < 0.05, respectively). These data suggest that 123I-BMIPP uptake of delayed H/M enhances the image of CHF severity. The myocardial WR of 123I-BMIPP also effectively depicted the severity of CHF.

Prognostic value of cardiac sympathetic nerve activity evaluated by [123I]m-iodobenzylguanidine imaging in patients with ST-segment elevation myocardial infarction.

PubMed

Kasama, Shu; Toyama, Takuji; Sumino, Hiroyuki; Kumakura, Hisao; Takayama, Yoshiaki; Minami, Kazutomo; Ichikawa, Shuichi; Matsumoto, Naoya; Sato, Yuichi; Kurabayashi, Masahiko

2011-01-01

Many studies have shown that cardiac sympathetic nerve activity evaluated by [(123)I]m-iodobenzylguanidine ([(123)I]MIBG) scintigraphic study during a stable period is useful for determining the prognosis of patients with chronic heart failure. To examine whether results of this imaging method performed 3 weeks after the onset of ST-segment elevation myocardial infarction (STEMI) are a reliable prognostic marker for patients with STEMI. The study analysed findings for 213 consecutive patients with STEMI undergoing [(123)I]MIBG scintigraphy. The left ventricular (LV) end-diastolic and end-systolic volume and LV ejection fraction (EF) were determined by left ventriculography or echocardiography 3 weeks after the onset of STEMI. The delayed total defect score, heart-to-mediastinum ratio and washout rate (WR) were also determined from [(123)I]MIBG scintigraphy at the same time. Of the 213 patients, 46 experienced major adverse cardiac events (MACE) during the study. The median follow-up period was 982 days. Patients were divided into an event-free group (n = 167; 78.4%) and a MACE group (n = 46; 21.6%). The LV and [(123)I]MIBG scintigraphic parameters in the event-free group were better than those in the MACE group. Multivariate Cox regression analyses revealed that WR was a significant predictor of MACE along with oral nicorandil (ATP-sensitive potassium channel opener) treatment and undergoing percutaneous coronary intervention. On Kaplan-Meier analysis, the event-free rate of patients with a WR<40% was significantly higher than that in patients with a WR ≥ 40% (p<0.001). Even when confined to patients with LVEF>45%, WR was a predictor of MACE, pump failure death, cardiac death and progression of heart failure in patients with STEMI. WR evaluated by [(123)I]MIBG scintigraphy 3 weeks after the onset of STEMI is a significant predictor of MACE in patients with STEMI, independent of LVEF.

Radiation protection of murine intestine by WR-2721, 16,16-dimethyl prostaglandin E2, and the combination of both agents

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hanson, W.R.

1987-08-01

The survival of murine intestinal clonogenic cells (ICC) and the survival of mice after whole-body exposure to /sup 137/Cs irradiation were used to measure radiation protection by ethiophos (WR-2721), 16,16-dimethyl prostaglandin E2, and the combination of the two. Doses from 2 to 12.5 mg/mouse of WR-2721 increased cell survival linearly from 3.2 +/- 0.3 in controls given 15.0 Gy to 93.1 +/- 5.2 per jejunal circumference. In contrast, 16,16-dm PGE2 increased ICC survival at 15.0 Gy rapidly from 1 to 10 micrograms/mouse, followed by a plateau up to 100 micrograms/mouse. Animal survival at 6 days (LD50/6) increased from 16.3 +/-more » 0.4 Gy (95% confidence limits) in controls to 20.3 +/- 0.6 Gy in the PG-treated animals. WR-2721 increased the LD50/6 to 26.1 +/- 1.4 Gy. The dose modification factors were 1.25 and 1.60, respectively. The combination of agents increased ICC survival above that seen with each agent alone up to 8 mg WR-2721, above which no additional protection was seen. Animals given 10 micrograms PG plus 10 mg WR-2721 survived longer than with either agent given alone. The LD50/6 was 36.3 +/- 1.8 Gy for a dose modification factor (DMF) of 2.23. In addition, the slope of the probit curve was reduced from those of each agent alone. PG-induced changes in villus epithelial cell morphology and survival may account, in part, for these observations. The results suggest that either the mechanisms for these two types of radiation protectors are different or they act on separate subcellular targets which are critical to survival from radiation injury.« less

Dynamic contrast-enhanced MRI for differentiation of major salivary glands neoplasms, a 3-T MRI study

PubMed Central

Aghaghazvini, L; Salahshour, F; Yazdani, N; Kooraki, S; Pakravan, M; Shakiba, M

2015-01-01

Objectives: Pre-operative differentiation of salivary gland neoplasms is of great importance. This study was designed to evaluate the use of dynamic contrast-enhanced MRI (DCE-MRI) for differentiation between malignant, Warthin and benign non-Warthin (BNW) neoplasms of major salivary glands. Methods: 46 major salivary gland tumours (SGTs) underwent pre-operative DCE-MRI. Post-surgical histopathological evaluation showed 30 BNW, 6 Warthin and 10 malignant tumours. Time–signal intensity curves (TICs) were categorized as (a) Tpeak >43 s and washout ratio at 180 s (WR180) <4.6%; (b) Tpeak <43 s and WR >22%; (c) Tpeak >43 s and WR180 = 4.6–22.0% Results: Accuracy of Tpeak was 98.9% for differentiation between BNW and Warthin tumours, 83.7% between BNW and malignant and 80% between malignant and Warthin tumours. All Warthin tumours showed Tpeak ≤43 s, while one BNW had Tpeak <43 s. A Tpeak <63.5 s differentiated 8/10 (80%) malignant tumours from BNW tumours, whereas 4/30 of BNW tumours had a Tpeak <63.5 s. Two malignant tumours had Tpeak <43 s. WR180 had an accuracy of 100% for differentiation between Warthin and BNW tumours, 87.3% between BNW and malignant, and 93.3% between Warthin and malignant tumours. 29 (96.7%) BNW tumours had a washout <4.60%, while 8 (80%) malignant tumours had a washout >4.60%. All Warthin tumours had a WR180 >22%, while two malignant tumours had a WR180 >22%. 29/30 of BNW tumours demonstrated TIC curve Type A and 1 tumour demonstrated Type C. 6/10 of malignant tumours had TIC Type C, 2 had TIC Type A and 2 Type B. All Warthin tumours were categorized as Type B. Conclusions: This study showed that DCE-MRI could be helpful in pre-operative differentiation of SGTs; especially for discrimination between Warthin and BNW tumours. PMID:25299931

Diet choice patterns in rodents depend on novelty of the diet, exercise, species, and sex.

PubMed

Yang, Tiffany; Xu, Wei-Jie; York, Haley; Liang, Nu-Chu

2017-07-01

Prolonged consumption of a palatable, high fat (HF) diet paired with a lack of physical activity can exacerbate the development of obesity. Exercise can facilitate the maintenance of a healthy body weight, possibly though mediating changes in diet preference. Using a two-diet choice and wheel running (WR) paradigm, our laboratory previously demonstrated that WR induces HF diet avoidance with different persistency in male and female rats when HF diet and WR are introduced simultaneously. The aims of this study were to examine whether this behavior is species dependent and to what extent the novelty of the diet affects WR induced HF diet avoidance. Experiment 1 utilized male C57BL6 mice in a two-diet choice and WR paradigm. Results show that all mice preferred HF to chow diet regardless of exercise and the order in which exercise and HF diet were presented. Experiment 2A (diet novelty) utilized Sprague-Dawley rats that were first habituated to a 45% HF diet prior to the simultaneous introduction of WR and a novel high-carbohydrate, low-fat (DK) diet. All rats avoided the novel high-carbohydrate diet and neither male nor female wheel running rats exhibited reduction in HF diet intake or HF diet avoidance. After all rats were returned to a sedentary condition, female rats consumed significantly more of the DK diet than the male rats. In Experiment 2B (diet familiarity), rats remained sedentary and were re-habituated to the DK diet until intake stabilized. Subsequently, a 60% HF diet was introduced for all rats and for running rats, access to the running wheels were provided simultaneously. Consistent with our previous findings, HF diet intake and preference was significantly reduced in all wheel running rats. These data suggest that exercise induced HF diet avoidance is affected by species and the novelty of the diet. Copyright © 2017 Elsevier Inc. All rights reserved.

Massive open star clusters using the VVV survey. II. Discovery of six clusters with Wolf-Rayet stars

NASA Astrophysics Data System (ADS)

Chené, A.-N.; Borissova, J.; Bonatto, C.; Majaess, D. J.; Baume, G.; Clarke, J. R. A.; Kurtev, R.; Schnurr, O.; Bouret, J.-C.; Catelan, M.; Emerson, J. P.; Feinstein, C.; Geisler, D.; de Grijs, R.; Hervé, A.; Ivanov, V. D.; Kumar, M. S. N.; Lucas, P.; Mahy, L.; Martins, F.; Mauro, F.; Minniti, D.; Moni Bidin, C.

2013-01-01

Context. The ESO Public Survey "VISTA Variables in the Vía Láctea" (VVV) provides deep multi-epoch infrared observations for an unprecedented 562 sq. degrees of the Galactic bulge, and adjacent regions of the disk. Nearly 150 new open clusters and cluster candidates have been discovered in this survey. Aims: This is the second in a series of papers about young, massive open clusters observed using the VVV survey. We present the first study of six recently discovered clusters. These clusters contain at least one newly discovered Wolf-Rayet (WR) star. Methods: Following the methodology presented in the first paper of the series, wide-field, deep JHKs VVV observations, combined with new infrared spectroscopy, are employed to constrain fundamental parameters for a subset of clusters. Results: We find that the six studied stellar groups are real young (2-7 Myr) and massive (between 0.8 and 2.2 × 103 M⊙) clusters. They are highly obscured (AV ~ 5-24 mag) and compact (1-2 pc). In addition to WR stars, two of the six clusters also contain at least one red supergiant star, and one of these two clusters also contains a blue supergiant. We claim the discovery of 8 new WR stars, and 3 stars showing WR-like emission lines which could be classified WR or OIf. Preliminary analysis provides initial masses of ~30-50 M⊙ for the WR stars. Finally, we discuss the spiral structure of the Galaxy using the six new clusters as tracers, together with the previously studied VVV clusters. Based on observations with ISAAC, VLT, ESO (programme 087.D-0341A), New Technology Telescope at ESO's La Silla Observatory (programme 087.D-0490A) and with the Clay telescope at the Las Campanas Observatory (programme CN2011A-086). Also based on data from the VVV survey (programme 172.B-2002).

Dose Accuracy and Injection Force of Different Insulin Glargine Pens

PubMed Central

Friedrichs, Arnd; Bohnet, Janine; Korger, Volker; Adler, Steffen; Schubert-Zsilavecz, Manfred; Abdel-Tawab, Mona

2013-01-01

Background Dose accuracy and injection force, representing key parameters of insulin pens, were determined for three pens delivering insulin glargine-based copies, Pen Royale (WR) and DispoPen (WD) for Glaritus® (Wockhardt) and GanLee Pen (GL) for Basalin® (Gan & Lee), compared with pens of the originator, ClikSTAR® (CS) and S o l o S TA R® (SS) for Lantus® (Sanofi) . Methods Using the weighing procedure recommended by DIN EN ISO 11608–1:2000, dose accuracy was evaluated based on nonrandomized delivery of low (5 U), mid (30 U), and high (60 U) dosage levels. Injection force was measured by dispensing the maximum dose of insulin (60 U for the GL, WR, and WD; 80 U for the SS and CS) at dose speeds of 6 and 10 U/s. Results All tested pens delivered comparable average doses within the DIN EN ISO 11608–1:2000 limits at all dosage levels. The GL revealed a higher coefficient of variation (CV) at 5 U, and the WR and WD had higher CVs at all dosage levels compared with the CS and SS. Injection force was higher for the WR, WD, and GL compared with the CS and SS at both dose speeds. In contrast to the CS and SS with an end-of-content feature, doses exceeding the remaining insulin could be dialed with the WR, GL, and WD and, apparently, dispensed with the WD. Conclusions All pens fulfilled the dose accuracy requirements defined by DIN EN ISO 11608–1:2000 standards at all three dosage levels, with the WR, WD, and GL showing higher dosage variability and injection force compared with the SS and CS. Thus, the devices that deliver insulin glargine copies show different performance characteristics compared with the originator. J Diabetes Sci Technol 2013;7(5):1346–1353 PMID:24124963

On the optically thick winds of Wolf-Rayet stars

NASA Astrophysics Data System (ADS)

Gräfener, G.; Owocki, S. P.; Grassitelli, L.; Langer, N.

2017-12-01

Context. The classical Wolf-Rayet (WR) phase is believed to mark the end stage of the evolution of massive stars with initial masses higher than 25M⊙. Stars in this phase expose their stripped cores with the products of H- or He-burning at their surface. They develop strong, optically thick stellar winds that are important for the mechanical and chemical feedback of massive stars, and that determine whether the most massive stars end their lives as neutron stars or black holes. The winds of WR stars are currently not well understood, and their inclusion in stellar evolution models relies on uncertain empirical mass-loss relations. Aims: We investigate theoretically the mass-loss properties of H-free WR stars of the nitrogen sequence (WN stars). Methods: We connected stellar structure models for He stars with wind models for optically thick winds and assessed the degree to which these two types of models can simultaneously fulfil their respective sonic-point conditions. Results: Fixing the outer wind law and terminal wind velocity ν∞, we obtain unique solutions for the mass-loss rates of optically thick, radiation-driven winds of WR stars in the phase of core He-burning. The resulting mass-loss relations as a function of stellar parameters agree well with previous empirical relations. Furthermore, we encounter stellar mass limits below which no continuous solutions exist. While these mass limits agree with observations of WR stars in the Galaxy, they contradict observations in the LMC. Conclusions: While our results in particular confirm the slope of often-used empirical mass-loss relations, they imply that only part of the observed WN population can be understood in the framework of the standard assumptions of a smooth transonic flow and compact stellar core. This means that alternative approaches such as a clumped and inflated wind structure or deviations from the diffusion limit at the sonic point may have to be invoked. Qualitatively, the existence of mass limits for the formation of WR-type winds may be relevant for the non-detection of low-mass WR stars in binary systems, which are believed to be progenitors of Type Ib/c supernovae. The sonic-point conditions derived in this work may provide a possibility to include optically thick winds in stellar evolution models in a more physically motivated form than in current models.

Voluntary wheel running increases satellite cell abundance and improves recovery from disuse in gastrocnemius muscles from mice.

PubMed

Brooks, Matthew J; Hajira, Ameena; Mohamed, Junaith S; Alway, Stephen E

2018-06-01

Reloading of atrophied muscles after hindlimb suspension unloading (HSU) can induce injury and prolong recovery. Low-impact exercise, such as voluntary wheel running, has been identified as a nondamaging rehabilitation therapy in rodents, but its effects on muscle function, morphology, and satellite cell activity after HSU are unclear. This study tested the hypothesis that low-impact wheel running would increase satellite cell proliferation and improve recovery of muscle structure and function after HSU in mice. Young adult male and female C57BL/6 mice ( n = 6/group) were randomly placed into five groups. These included HSU without recovery (HSU), normal ambulatory recovery for 14 days after HSU (HSU+NoWR), and voluntary wheel running recovery for 14 days after HSU (HSU+WR). Two control groups were used: nonsuspended mouse cage controls (Control) and voluntary wheel running controls (ControlWR). Satellite cell activation was evaluated by providing mice 5-bromo-2'-deoxyuridine (BrdU) in their drinking water. As expected, HSU significantly reduced in vivo maximal force, decreased in vivo fatigability, and decreased type I and IIa myosin heavy chain (MHC) abundance in plantarflexor muscles. HSU+WR mice significantly improved plantarflexor fatigue resistance, increased type I and IIa MHC abundance, increased fiber cross-sectional area, and increased the percentage of type I and IIA muscle fibers in the gastrocnemius muscle. HSU+WR mice also had a significantly greater percentage of BrdU-positive and Pax 7-positive nuclei inside muscle fibers and a greater MyoD-to-Pax 7 protein ratio compared with HSU+NoWR mice. The mechanotransduction protein Yes-associated protein (YAP) was elevated with reloading after HSU, but HSU+WR mice had lower levels of the inactive phosphorylated YAP serine127 , which may have contributed to increased satellite cell activation with reloading after HSU. These results indicate that voluntary wheel running increased YAP signaling and satellite cell activity after HSU and this was associated with improved recovery. NEW & NOTEWORTHY Although satellite cell involvement in muscle remodeling has been challenged, the data in this study suggest that voluntary wheel running increased satellite cell activity and suppressed Yes-associated protein (YAP) protein relative to no wheel running and this was associated with improved muscle recovery of force, fatigue resistance, expression of type I myosin heavy chain, and greater fiber cross-sectional area after disuse.

A Petrogenetic Evaluation of Clinopyroxene-hosted Melt Inclusions from an Enriched Submarine Lava of the Samoan Hotspot Track: A Phase Equilibria and Diffusion Modeling Study

NASA Astrophysics Data System (ADS)

Adams, J.; Spera, F. J.; Jackson, M. G.; Schmidt, J.

2017-12-01

The Samoan hotspot track hosts lavas that are representative of the Enriched Mantle II (EMII) geochemical signature, long thought to result from incorporation of recycled upper continental crust. Silicic (66-69 wt% SiO2) clinopyroxene (cpx)-hosted melt inclusions (MI) from isotopically enriched lavas from Samoa provide a window into their petrogenetic evolution. Enriched Samoan submarine lava, ALIA-115-18, from Savai'i Island, Samoa contains clinopyroxene (cpx) antecrysts that host uniformly trachydacitic MI's. The cpx's are more radiogenic (87Sr/86Sr=0.720232-0.720830) than the host whole rock (WR) (87Sr/86Sr=0.718592) providing evidence of cpx antecryst-WR disequilibrium (Jackson et al., 2007, 2009). Phase equilibria calculations using the Magma Chamber Simulator (Bohrson et al., 2014) have corroborated a lack of relationship by fractional crystallization (FC) between the antecrysts and WR composition as well as the cpx's and MI's. Cpx thermobarometry reveals cpx antecryst-WR disequilibrium is not a pressure effect but rather reflects cpx crystallization from a more magnesian parental melt (similar to the most mafic WR of the Samoan submarine lavas; SiO2=49 wt%, MgO=9 wt%), different than the ALIA-115-18 WR. The cpx antecrysts (Mg#72-86), and the rest of the antecryst population show a crystallization range of 1-5 kbar. Cpx groundmass phenocrysts (Mg#70-75) are consistent with ALIA-115-18 WR (SiO2=55 wt%, MgO=5 wt%) composition by FC in the 1-5 kbar range. The more mafic parent may represent the magma that mixed with evolved magmas, giving rise to radiogenic ALIA-115-18, and possibly the silicic MI's. Thus, studying the petrogenesis of the MI's is essential to understanding the evolution of EMII. Many cpx antecrysts with MI's are characterized by compositional halos; transects across the halos exhibit major and trace element gradients. Modeling of diffusive exchange (Cottrell et al., 2002) between the MI's and their host lavas, mediated by diffusion through cpx, allows one to constrain post-entrapment timescales. Preliminary results show distinct gradients in Al, Ti, Si, Cr, Sr, Zr, and the REEs. These elements cover a wide range of diffusivities and partition coefficients enabling a detailed timescale study of post-entrapment MI evolution and the petrogenesis of the Samoan lava suite.

Amount of leachant and water absorption levels of wood treated with borates and water repellents.

PubMed

Baysal, Ergun; Sonmez, Abdullah; Colak, Mehmet; Toker, Hilmi

2006-12-01

Wood protection efficacy of borates against biological agents, flame retardancy, and suitability to the environment is well known. Since borates can be applied to timber as water based solutions, they are preferred economically as well. Even though they are highly mobile in wood, boron compounds are widely used in timber preservation. Borates migrate in liquid and increase the hygroscopicity of wood in damp conditions. This study deals with the physical restriction of water access in wood by impregnating water repellent agents into wood to limit amount of leachant and water absorption levels of wood after boron treatment. Borates were incorporated with polyethylene glycol-400 (PEG-400) their bulking effect in wood was considered. Results indicated that the amount of leachates from wood treated with borates in PEG-400 was remarkably higher compared to those of wood treated with the aqueous solutions of borates. Water absorption (WA) levels of wood treated with aqueous solutions of borates were higher than those of their treated samples with the solutions in PEG-400. Secondary treatments of wood with the water repellent (WR) chemicals following borate impregnation reduced the leaching of chemicals from wood in water and also WA of the specimens were less than those of the wood treated with only borates from aqueous and PEG solutions. Styrene (St) was the most effective monomer among the other agents used in terms of immobility effect on borates and WA.

Photosynthetic Responses to the Environment. Proceedings Symposium held August 24 - 27, 1992. Volume 8

DTIC Science & Technology

1992-08-27

seedlings were grown in Wagner pots that were filled with 5 continuously aerated hydroponic solutions of various nitrate concentrations according to Hewitt...seeded Simpson, were grown by hydroponics inside Conviron growth chambers (model E15). The description of the hydroponic system, the growth solutions , and...control. In Briggs WR ed, Photosynthesis, Alan R Liss, New York, pp 183-205 8. Evans JR, Terashlma I (1988) Photosynthetic characteristics of spinach

Situation Awareness: Papers and Annotated Bibliography

DTIC Science & Technology

1994-06-01

identification 133. McKinley, R.L., Erikson , M.A., and D’Angelo, W.R. (1994). 3-Dimensional auditory displays: Development , applications, and...constructed. The second paper, by Dr. Michael Vidulich, was originally written during the early stages of the SAINT team’s response to SA concerns raised...refers to how SA is developed and maintained during flight, while the product is the resultant, elusive thing we call SA itself (Tenney, Adams, Pew

Radiant Heat Testing of the H1224A Shipping/Storage Container

DTIC Science & Technology

1994-05-01

re - entry vehicles caused by credible accidents during air and ground transportation. Radiant heat testing of the H1224A storage/shipping container is...inner container, and re - entry vehicle (RV) temperatures during radiant heat testing. Computer modelling can be used to predict weapon response throughout...Nomenclature RV Re - entry Vehicle midsection mass mock-up WR War Reserve STS Stockpile-to-Target Sequence NAWC Simulated H1224A container by Naval Air

Compact microwave lamp having a tuning block and a dielectric located in a lamp cavity

DOEpatents

Simpson, James E.

2000-01-01

A microwave lamp having a compact structure utilizing a coupling slot which has a dielectric member extending therethrough and a tuning block adjoining the coupling slot. A non-conventional waveguide is used which has about the width of a WR-284 waveguide and about the length of a WR-340 waveguide.

The Influence of Exercise Intensity on Postexercise Baroreflex Sensitivity

ERIC Educational Resources Information Center

Reynolds, Linda J.; De Ste Croix, Mark B. A.; James, David V. B.

2017-01-01

Purpose: The purpose of this study was to investigate the influence of exercise intensity on postexercise supine and tilt baroreflex sensitivity (BRS). Method: Nine healthy, active men performed 2 conditions of interval cycling of 40% maximal work rate (WR[subscript max]) and 75% WR[subscript max] of matched work done and a control condition of no…

Prophylactic activity of mefloquine hydrochloride (WR 142 490) in drug-resistant malaria*

PubMed Central

Rieckmann, K. H.; Trenholme, G. M.; Williams, R. L.; Carson, P. E.; Frischer, H.; Desjardins, R. E.

1974-01-01

In preliminary studies with mefloquine (WR 142 490) a single dose exerted prolonged suppressive activity against a drug-resistant strain of Plasmodium falciparum. Development of patent parasitaemia was prevented when nonimmune persons were exposed to infected mosquitos 2 weeks after medication, and it was delayed when exposure occurred 3 weeks after drug administration. PMID:4619059

PopIII-star siblings in IZw18 and metal-poor WR galaxies unveiled from integral field spectroscopy

NASA Astrophysics Data System (ADS)

Kehrig, C.; Vílchez, J. M.; Pérez-Montero, E.; Iglesias-Páramo, J.; Brinchmann, J.; Crowther, P. A.; Durret, F.; Kunth, D.

Here, we highlight our recent results from the IFS study of Mrk178, the closest metal-poor WR galaxy, and of IZw18, the most metal-poor star-forming galaxy known in the local Universe. The IFS data of Mrk178 show the importance of aperture effects on the search for WR features, and the extent to which physical variations in the ISM properties can be detected. Our IFS data of IZw18 reveal its entire nebular HeIIλ4686-emitting region, and indicate for the very first time that peculiar, hot (nearly) metal-free ionizing stars (called here PopIII-star siblings) might hold the key to the HeII-ionization in IZw18.

Discovery of a New Wolf-Rayet Star Using SAGE-LMC

NASA Astrophysics Data System (ADS)

Gvaramadze, V. V.; Chené, A.-N.; Kniazev, A. Y.; Schnurr, O.

2012-12-01

We report the first-ever discovery of an extragalactic Wolf-Rayet (WR) star with Spitzer. A new WR star in the Large Magellanic Cloud (LMC) was revealed via detection of its circumstellar shell using 24 μm images obtained in the framework of the Spitzer Survey of the Large Magellanic Cloud (SAGE-LMC). Subsequent spectroscopic observations with the Gemini South resolved the central star in two components, one of which is a WN3b+abs star, while the second one is a B0 V star. We consider the lopsided brightness distribution over the circumstellar shell as an indication that the WR star is a runaway and use this interpretation to identify a possible parent cluster of the star.

K-Band Latching Switches

NASA Technical Reports Server (NTRS)

Piotrowski, W. S.; Raue, J. E.

1984-01-01

Design, development, and tests are described for two single-pole-double-throw latching waveguide ferrite switches: a K-band switch in WR-42 waveguide and a Ka-band switch in WR-28 waveguide. Both switches have structurally simple junctions, mechanically interlocked without the use of bonding materials; they are impervious to the effects of thermal, shock, and vibration stresses. Ferrite material for the Ka-band switch with a proper combination of magnetic and dielectric properties was available and resulted in excellent low loss, wideband performance. The high power handling requirement of the K-band switch limited the choice of ferrite to nickel-zinc compositions with adequate magnetic properties, but with too low relative dielectric constant. The relative dielectric constant determines the junction dimensions for given frequency responses. In this case the too low value unavoidably leads to a larger than optimum junction volume, increasing the insertion loss and restricting the operating bandwidth. Efforts to overcome the materials-related difficulties through the design of a composite junction with increased effective dielectric properties efforts to modify the relative dielectric constant of nickel-zinc ferrite are examined.

Weak central coherence in weight-restored adolescent anorexia nervosa: Characteristics and remediation.

PubMed

Weinbach, Noam; Perry, Amit; Sher, Helene; Lock, James D; Henik, Avishai

2017-08-01

Weak central coherence (WCC) refers to a bias towards processing details (local processing) at the expense of paying attention to the bigger picture (global processing). Multiple studies reported WCC in adults with anorexia nervosa (AN). Evidence for WCC in adolescents with AN has been inconsistent. The current study characterizes WCC in weight-restored adolescents with AN (WR-AN) using a direct measure of WCC, and examines whether WCC can be remediated by increasing alertness level-a manipulation that was found useful in enhancing global processing in healthy individuals and clinical populations. 40 adolescents (18 WR-AN and 22 healthy adolescents) performed a global/local processing task (Navon task). Auditory alerting cues that elevate alertness level were integrated into the task. Both groups processed global information faster than local information. However, compared with controls, adolescents with WR-AN were better at ignoring an irrelevant bigger picture while attending to details (smaller global interference) and had greater difficulty ignoring irrelevant details while attending to the bigger picture (larger local interference). These differences were attenuated when adolescents with WR-AN were under a state of high alertness. Additionally, the local interference effect was positively correlated with three independent self-report questionnaires assessing eating disorders symptomatology. This study suggests that abnormal interference by irrelevant global and local information is a central characteristic of WCC in adolescents with WR-AN that cannot be accounted for by enduring illness or malnourishment. Additionally, this study demonstrates that WCC can be temporarily remediated by encouraging a state of high alertness. © 2017 Wiley Periodicals, Inc.

A survey of nebulae around galactic wolf-rayet stars in the southern sky, 2.

NASA Technical Reports Server (NTRS)

Marston, A. P.; Yocum, D. R.; Garcia-Segura, G.; Chu, Y.-H.

1994-01-01

We present the second half of a charge coupled device (CCD) narrow-band imaging survey of galactic Wolf-Rayet stars located in the southern hemisphere as listed by van der Hucht et al. (1981). Images of 50 Wolf-Rayet stars were taken using a wide-field CCD and narrowband interference filters centered on H alpha and (O III) 5007 A wavelengths. The first half of the survey (Marston, Chu, & Garcia-Segura 1993, hereafter Paper I) revealed six new ring nebulae residing around Wolf-Rayet stars. Here we reveal a possible 11 new rings and the existence of multiple rings associated with two previously known nebula, RCW 118 and G2.4+1.4 and around the stars WR 16 and WR 43. Combining our results with those of Miller & Chu (1993) and Paper I, 92% of the van der Hucht catalog of Wolf-Rayet stars have now been surveyed. Of the 38 possible ring nebulae found in our surveys to date, 22 reside around WN subtype Wolf-Rayet stars, 13 around WC stars, one around a triplet of Wolf-Rayet stars and one around a WO star (WR 102). One ring exists around a WN/WC star (WR 98). A bias toward rings being observed around W-R + OB binaries is noted. Such pairings are generally bright, and the detection of a ring around them may merely be a function of their combined luminosity. Several Wolf-Rayet stars are shown to be surrounded by multiple rings (two or three) which suggests that a number of ejections of stellar material have taken place during their evolution.

Modulation of Radiation-Induced Apoptosis by Thiolamines

NASA Technical Reports Server (NTRS)

Warters, R. L.; Roberts, J. C.; Wilmore, B. H.; Kelley, L. L.

1997-01-01

Exposure to the thiolamine radioprotector N-(2-mercaptoethyl)-1,3-propanediamine (WR-1065) induced apoptosis in the mouse TB8-3 hybridoma after 60-minute (LD(sub50) = 4.5mM) or during a 20-hour (LD(sub50) = 0.15 mM) exposure. In contrast, a 20-hour exposure to 17 mM L-cysteine or 10 mM cysteamine was required to induce 50 percent apoptosis within 20 hours. Apoptosis was not induced by either a 60-minute or 20-hour exposure to 10 mM of the thiazolidime prodrugs ribose-cysteine (RibCys) or ribose-cysteamine (RibCyst). Thiolamine-induced apoptosis appeared to be a p53-independent process since it was induced by WR-1065 exposure in human HL60 cells. Exposure to WR-1065 (4mM for 15 minutes) or cysteine (10mM for 60 minutes) before and during irradiation protected cells against the induction of both DNA double-strand breaks and apoptosis, while exposure to RibCys (10 mM for 3 hours) did not. Treatment with either WR-1065, cysteine, RibCys or RibCyst for 60 minutes beginning 60 minutes after irradiation did not affect the level of radiation-induced apoptosis. In contrast, treatment with either cysteine, cysteamine or RibCys for 20 hours beginning 60 minutes after irradiation enhanced radiation-induced apoptosis. Similar experiments could not be conducted with WR-1065 because of its extreme toxicity. Our results indicate that thiolamine enhancement of radiation-induced apoptosis is not involved in their previously reported capacity to reduce radiation-induced mutations.

Interindividual uniformity and variety of the "Writing center": a functional MRI study.

PubMed

Sugihara, Genichi; Kaminaga, Tatsuro; Sugishita, Morihiro

2006-10-01

Our aim is to investigate the neural substrates for writing using fMRI (twenty right-handed subjects). We assumed that common areas involved in both writing with right and left hands are crucial to the central process of writing. We employed Japanese phonograms (Kana), in which phoneme-grapheme conversion would be extremely simple. Brain activation was examined under three conditions: (1) written naming with the right hand (WR), (2) written naming with the left hand (WL), and (3) naming silently (NA). While the comparison of WR to NA (WR>NA) exhibited activation only in the left frontoparietal area, the WL>NA comparison exhibited broader activation than the WR>NA comparison, i.e., the left frontoparietal area except the motor and sensory areas and the right frontoparietal area. A conjunction analysis in SPM2 revealed common areas of activation across the WR>NA and WL>NA comparisons, which are assumed to be crucial to writing. In the group analysis, three areas were found to be activated: the posterior end of the left superior frontal gyrus, which is superior and posterior to Exner's center; the anterior part of the left superior parietal lobule; and the lower part of the anterior limb of the left supramarginal gyrus. In the single-subject analysis, whereas the first two of the above three areas were found to be crucial for writing in all individuals, an interindividual inconsistency of involvement with writing was observed in three areas: the lower part of the anterior limb of the left supramarginal gyrus (60% involved); the right frontal region (47%); and the right intraparietal sulcus (47%).

Hot Gas in the Wolf–Rayet Nebula NGC 3199

DOE Office of Scientific and Technical Information (OSTI.GOV)

Toalá, J. A.; Chu, Y.-H.; Marston, A. P.

The Wolf–Rayet (WR) nebula NGC 3199 has been suggested to be a bow shock around its central star, WR 18, which is presumably a runaway star, because optical images of the nebula show a dominating arc of emission southwest of the star. We present the XMM-Newton detection of extended X-ray emission from NGC 3199, unveiling the powerful effect of the fast wind from WR 18. The X-ray emission is brighter in the region southeast of the star and an analysis of the spectral properties of the X-ray emission reveals abundance variations: (i) regions close to the optical arc present nitrogen-richmore » gas enhanced by the stellar wind from WR 18 and (ii) gas at the eastern region exhibits abundances close to those reported for the nebular abundances derived from optical studies, which is a signature of an efficient mixing of the nebular material with the stellar wind. The dominant plasma temperature and electron density are estimated to be T ≈ 1.2 × 10{sup 6} K and n {sub e} = 0.3 cm{sup −3} with an X-ray luminosity in the 0.3–3.0 keV energy range of L {sub X} = 2.6 × 10{sup 34} erg s{sup −1}. Combined with information derived from Herschel and the recent Gaia first data release, we conclude that WR 18 is not a runaway star and that the formation, chemical variations, and the shape of NGC 3199 depend on the initial configuration of the interstellar medium.« less

Molecular Cytogenetic Identification of a New Wheat-Rye 6R Chromosome Disomic Addition Line with Powdery Mildew Resistance

PubMed Central

An, Diaoguo; Zheng, Qi; Luo, Qiaoling; Ma, Pengtao; Zhang, Hongxia; Li, Lihui; Han, Fangpu; Xu, Hongxing; Xu, Yunfeng; Zhang, Xiaotian; Zhou, Yilin

2015-01-01

Rye (Secale cereale L.) possesses many valuable genes that can be used for improving disease resistance, yield and environment adaptation of wheat (Triticum aestivum L.). However, the documented resistance stocks derived from rye is faced severe challenge due to the variation of virulent isolates in the pathogen populations. Therefore, it is necessary to develop desirable germplasm and search for novel resistance gene sources against constantly accumulated variation of the virulent isolates. In the present study, a new wheat-rye line designated as WR49-1 was produced through distant hybridization and chromosome engineering protocols between common wheat cultivar Xiaoyan 6 and rye cultivar German White. Using sequential GISH (genomic in situ hybridization), mc-FISH (multicolor fluorescence in situ hybridization), mc-GISH (multicolor GISH) and EST (expressed sequence tag)-based marker analysis, WR49-1 was proved to be a new wheat-rye 6R disomic addition line. As expected, WR49-1 showed high levels of resistance to wheat powdery mildew (Blumeria graminis f. sp. tritici, Bgt) pathogens prevalent in China at the adult growth stage and 19 of 23 Bgt isolates tested at the seedling stage. According to its reaction pattern to different Bgt isolates, WR49-1 may possess new resistance gene(s) for powdery mildew, which differed from the documented powdery mildew gene, including Pm20 on chromosome arm 6RL of rye. Additionally, WR49-1 was cytologically stable, had improved agronomic characteristics and therefore could serve as an important bridge for wheat breeding and chromosome engineering. PMID:26237413

A survey of nebulae around galactic wolf-rayet stars in the southern sky, 2.

NASA Astrophysics Data System (ADS)

Marston, A. P.; Yocum, D. R.; Garcia-Segura, G.; Chu, Y.-H.

1994-11-01

We present the second half of a charge coupled device (CCD) narrow-band imaging survey of galactic Wolf-Rayet stars located in the southern hemisphere as listed by van der Hucht et al. (1981). Images of 50 Wolf-Rayet stars were taken using a wide-field CCD and narrowband interference filters centered on H alpha and (O III) 5007 A wavelengths. The first half of the survey (Marston, Chu, & Garcia-Segura 1993, hereafter Paper I) revealed six new ring nebulae residing around Wolf-Rayet stars. Here we reveal a possible 11 new rings and the existence of multiple rings associated with two previously known nebula, RCW 118 and G2.4+1.4 and around the stars WR 16 and WR 43. Combining our results with those of Miller & Chu (1993) and Paper I, 92% of the van der Hucht catalog of Wolf-Rayet stars have now been surveyed. Of the 38 possible ring nebulae found in our surveys to date, 22 reside around WN subtype Wolf-Rayet stars, 13 around WC stars, one around a triplet of Wolf-Rayet stars and one around a WO star (WR 102). One ring exists around a WN/WC star (WR 98). A bias toward rings being observed around W-R + OB binaries is noted. Such pairings are generally bright, and the detection of a ring around them may merely be a function of their combined luminosity. Several Wolf-Rayet stars are shown to be surrounded by multiple rings (two or three) which suggests that a number of ejections of stellar material have taken place during their evolution.

Hidden Milky Way star clusters hosting Wolf-Rayet stars

NASA Astrophysics Data System (ADS)

Kurtev, R.; Borissova, J.; Ivanov, V. D.; Georgiev, L.

2009-05-01

A noticeable fraction of the hidden young star clusters contain WR and O stars providing us with unique laboratories to study the evolution of these rare objects and their maternity places. We are reporting the reddening, the distance and age of two new members of the family of massive young Galactic clusters, hosting WR stars - Glimpse 23 and Glimpse 30.

Search for a heavy right-handed W boson and a heavy neutrino in events with two same-flavor leptons and two jets at √{s}=13 TeV

NASA Astrophysics Data System (ADS)

Sirunyan, A. M.; Tumasyan, A.; Adam, W.; Ambrogi, F.; Asilar, E.; Bergauer, T.; Brandstetter, J.; Brondolin, E.; Dragicevic, M.; Erö, J.; Escalante Del Valle, A.; Flechl, M.; Friedl, M.; Frühwirth, R.; Ghete, V. M.; Grossmann, J.; Hrubec, J.; Jeitler, M.; König, A.; Krammer, N.; Krätschmer, I.; Liko, D.; Madlener, T.; Mikulec, I.; Pree, E.; Rad, N.; Rohringer, H.; Schieck, J.; Schöfbeck, R.; Spanring, M.; Spitzbart, D.; Taurok, A.; Waltenberger, W.; Wittmann, J.; Wulz, C.-E.; Zarucki, M.; Chekhovsky, V.; Mossolov, V.; Suarez Gonzalez, J.; De Wolf, E. A.; Di Croce, D.; Janssen, X.; Lauwers, J.; Pieters, M.; Van De Klundert, M.; Van Haevermaet, H.; Van Mechelen, P.; Van Remortel, N.; Abu Zeid, S.; Blekman, F.; D'Hondt, J.; De Bruyn, I.; De Clercq, J.; Deroover, K.; Flouris, G.; Lontkovskyi, D.; Lowette, S.; Marchesini, I.; Moortgat, S.; Moreels, L.; Python, Q.; Skovpen, K.; Tavernier, S.; Van Doninck, W.; Van Mulders, P.; Van Parijs, I.; Beghin, D.; Bilin, B.; Brun, H.; Clerbaux, B.; De Lentdecker, G.; Delannoy, H.; Dorney, B.; Fasanella, G.; Favart, L.; Goldouzian, R.; Grebenyuk, A.; Kalsi, A. 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M.; Khakzad, M.; Mohammadi Najafabadi, M.; Naseri, M.; Paktinat Mehdiabadi, S.; Rezaei Hosseinabadi, F.; Safarzadeh, B.; Zeinali, M.; Felcini, M.; Grunewald, M.; Abbrescia, M.; Calabria, C.; Colaleo, A.; Creanza, D.; Cristella, L.; De Filippis, N.; De Palma, M.; Di Florio, A.; Errico, F.; Fiore, L.; Gelmi, A.; Iaselli, G.; Lezki, S.; Maggi, G.; Maggi, M.; Marangelli, B.; Miniello, G.; My, S.; Nuzzo, S.; Pompili, A.; Pugliese, G.; Radogna, R.; Ranieri, A.; Selvaggi, G.; Sharma, A.; Silvestris, L.; Venditti, R.; Verwilligen, P.; Zito, G.; Abbiendi, G.; Battilana, C.; Bonacorsi, D.; Borgonovi, L.; Braibant-Giacomelli, S.; Brigliadori, L.; Campanini, R.; Capiluppi, P.; Castro, A.; Cavallo, F. R.; Chhibra, S. S.; Codispoti, G.; Cuffiani, M.; Dallavalle, G. M.; Fabbri, F.; Fanfani, A.; Fasanella, D.; Giacomelli, P.; Grandi, C.; Guiducci, L.; Marcellini, S.; Masetti, G.; Montanari, A.; Navarria, F. L.; Perrotta, A.; Rossi, A. M.; Rovelli, T.; Siroli, G. 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S.; Oh, Y. D.; Sekmen, S.; Son, D. C.; Yang, Y. C.; Kim, H.; Moon, D. H.; Oh, G.; Brochero Cifuentes, J. A.; Goh, J.; Kim, T. J.; Cho, S.; Choi, S.; Go, Y.; Gyun, D.; Ha, S.; Hong, B.; Jo, Y.; Kim, Y.; Lee, K.; Lee, K. S.; Lee, S.; Lim, J.; Park, S. K.; Roh, Y.; Almond, J.; Kim, J.; Kim, J. S.; Lee, H.; Lee, K.; Nam, K.; Oh, S. B.; Radburn-Smith, B. C.; Seo, S. h.; Yang, U. K.; Yoo, H. D.; Yu, G. B.; Kim, H.; Kim, J. H.; Lee, J. S. H.; Park, I. C.; Choi, Y.; Hwang, C.; Lee, J.; Yu, I.; Dudenas, V.; Juodagalvis, A.; Vaitkus, J.; Ahmed, I.; Ibrahim, Z. A.; Md Ali, M. A. B.; Mohamad Idris, F.; Wan Abdullah, W. A. T.; Yusli, M. N.; Zolkapli, Z.; Reyes-Almanza, R.; Ramirez-Sanchez, G.; Duran-Osuna, M. C.; Castilla-Valdez, H.; De La Cruz-Burelo, E.; Heredia-De La Cruz, I.; Rabadan-Trejo, R. I.; Lopez-Fernandez, R.; Mejia Guisao, J.; Sanchez-Hernandez, A.; Carrillo Moreno, S.; Oropeza Barrera, C.; Vazquez Valencia, F.; Eysermans, J.; Pedraza, I.; Salazar Ibarguen, H. A.; Uribe Estrada, C.; Morelos Pineda, A.; Krofcheck, D.; Bheesette, S.; Butler, P. H.; Ahmad, A.; Ahmad, M.; Hassan, Q.; Hoorani, H. R.; Saddique, A.; Shah, M. A.; Shoaib, M.; Waqas, M.; Bialkowska, H.; Bluj, M.; Boimska, B.; Frueboes, T.; Górski, M.; Kazana, M.; Nawrocki, K.; Szleper, M.; Traczyk, P.; Zalewski, P.; Bunkowski, K.; Byszuk, A.; Doroba, K.; Kalinowski, A.; Konecki, M.; Krolikowski, J.; Misiura, M.; Olszewski, M.; Pyskir, A.; Walczak, M.; Bargassa, P.; Beirão Da Cruz E Silva, C.; Di Francesco, A.; Faccioli, P.; Galinhas, B.; Gallinaro, M.; Hollar, J.; Leonardo, N.; Lloret Iglesias, L.; Nemallapudi, M. V.; Seixas, J.; Strong, G.; Toldaiev, O.; Vadruccio, D.; Varela, J.; Afanasiev, S.; Bunin, P.; Gavrilenko, M.; Golutvin, I.; Gorbunov, I.; Kamenev, A.; Karjavin, V.; Lanev, A.; Malakhov, A.; Matveev, V.; Moisenz, P.; Palichik, V.; Perelygin, V.; Shmatov, S.; Shulha, S.; Skatchkov, N.; Smirnov, V.; Voytishin, N.; Zarubin, A.; Ivanov, Y.; Kim, V.; Kuznetsova, E.; Levchenko, P.; Murzin, V.; Oreshkin, V.; Smirnov, I.; Sosnov, D.; Sulimov, V.; Uvarov, L.; Vavilov, S.; Vorobyev, A.; Andreev, Yu.; Dermenev, A.; Gninenko, S.; Golubev, N.; Karneyeu, A.; Kirsanov, M.; Krasnikov, N.; Pashenkov, A.; Tlisov, D.; Toropin, A.; Epshteyn, V.; Gavrilov, V.; Lychkovskaya, N.; Popov, V.; Pozdnyakov, I.; Safronov, G.; Spiridonov, A.; Stepennov, A.; Stolin, V.; Toms, M.; Vlasov, E.; Zhokin, A.; Aushev, T.; Bylinkin, A.; Chadeeva, M.; Parygin, P.; Philippov, D.; Polikarpov, S.; Popova, E.; Rusinov, V.; Andreev, V.; Azarkin, M.; Dremin, I.; Kirakosyan, M.; Rusakov, S. V.; Terkulov, A.; Baskakov, A.; Belyaev, A.; Boos, E.; Bunichev, V.; Dubinin, M.; Dudko, L.; Ershov, A.; Gribushin, A.; Klyukhin, V.; Kodolova, O.; Lokhtin, I.; Miagkov, I.; Obraztsov, S.; Perfilov, M.; Savrin, V.; Blinov, V.; Shtol, D.; Skovpen, Y.; Azhgirey, I.; Bayshev, I.; Bitioukov, S.; Elumakhov, D.; Godizov, A.; Kachanov, V.; Kalinin, A.; Konstantinov, D.; Mandrik, P.; Petrov, V.; Ryutin, R.; Sobol, A.; Troshin, S.; Tyurin, N.; Uzunian, A.; Volkov, A.; Babaev, A.; Adzic, P.; Cirkovic, P.; Devetak, D.; Dordevic, M.; Milosevic, J.; Alcaraz Maestre, J.; Bachiller, I.; Barrio Luna, M.; Cerrada, M.; Colino, N.; De La Cruz, B.; Delgado Peris, A.; Fernandez Bedoya, C.; Fernández Ramos, J. P.; Flix, J.; Fouz, M. C.; Gonzalez Lopez, O.; Goy Lopez, S.; Hernandez, J. M.; Josa, M. I.; Moran, D.; Pérez-Calero Yzquierdo, A.; Puerta Pelayo, J.; Redondo, I.; Romero, L.; Soares, M. S.; Triossi, A.; Álvarez Fernández, A.; Albajar, C.; de Trocóniz, J. F.; Cuevas, J.; Erice, C.; Fernandez Menendez, J.; Folgueras, S.; Gonzalez Caballero, I.; González Fernández, J. R.; Palencia Cortezon, E.; Sanchez Cruz, S.; Vischia, P.; Vizan Garcia, J. M.; Cabrillo, I. J.; Calderon, A.; Chazin Quero, B.; Duarte Campderros, J.; Fernandez, M.; Fernández Manteca, P. J.; Garcia-Ferrero, J.; García Alonso, A.; Gomez, G.; Lopez Virto, A.; Marco, J.; Martinez Rivero, C.; Martinez Ruiz del Arbol, P.; Matorras, F.; Piedra Gomez, J.; Prieels, C.; Rodrigo, T.; Ruiz-Jimeno, A.; Scodellaro, L.; Trevisani, N.; Vila, I.; Vilar Cortabitarte, R.; Abbaneo, D.; Akgun, B.; Auffray, E.; Baillon, P.; Ball, A. H.; Barney, D.; Bendavid, J.; Bianco, M.; Bocci, A.; Botta, C.; Camporesi, T.; Cepeda, M.; Cerminara, G.; Chapon, E.; Chen, Y.; d'Enterria, D.; Dabrowski, A.; Daponte, V.; David, A.; De Gruttola, M.; De Roeck, A.; Deelen, N.; Dobson, M.; du Pree, T.; Dünser, M.; Dupont, N.; Elliott-Peisert, A.; Everaerts, P.; Fallavollita, F.; Franzoni, G.; Fulcher, J.; Funk, W.; Gigi, D.; Gilbert, A.; Gill, K.; Glege, F.; Gulhan, D.; Hegeman, J.; Innocente, V.; Jafari, A.; Janot, P.; Karacheban, O.; Kieseler, J.; Knünz, V.; Kornmayer, A.; Krammer, M.; Lange, C.; Lecoq, P.; Lourenço, C.; Lucchini, M. T.; Malgeri, L.; Mannelli, M.; Martelli, A.; Meijers, F.; Merlin, J. A.; Mersi, S.; Meschi, E.; Milenovic, P.; Moortgat, F.; Mulders, M.; Neugebauer, H.; Ngadiuba, J.; Orfanelli, S.; Orsini, L.; Pantaleo, F.; Pape, L.; Perez, E.; Peruzzi, M.; Petrilli, A.; Petrucciani, G.; Pfeiffer, A.; Pierini, M.; Pitters, F. M.; Rabady, D.; Racz, A.; Reis, T.; Rolandi, G.; Rovere, M.; Sakulin, H.; Schäfer, C.; Schwick, C.; Seidel, M.; Selvaggi, M.; Sharma, A.; Silva, P.; Sphicas, P.; Stakia, A.; Steggemann, J.; Stoye, M.; Tosi, M.; Treille, D.; Tsirou, A.; Veckalns, V.; Verweij, M.; Zeuner, W. D.; Bertl, W.; Caminada, L.; Deiters, K.; Erdmann, W.; Horisberger, R.; Ingram, Q.; Kaestli, H. C.; Kotlinski, D.; Langenegger, U.; Rohe, T.; Wiederkehr, S. A.; Backhaus, M.; Bäni, L.; Berger, P.; Casal, B.; Chernyavskaya, N.; Dissertori, G.; Dittmar, M.; Donegà, M.; Dorfer, C.; Grab, C.; Heidegger, C.; Hits, D.; Hoss, J.; Klijnsma, T.; Lustermann, W.; Marionneau, M.; Meinhard, M. T.; Meister, D.; Micheli, F.; Musella, P.; NessiTedaldi, F.; Pata, J.; Pauss, F.; Perrin, G.; Perrozzi, L.; Quittnat, M.; Reichmann, M.; Ruini, D.; Sanz Becerra, D. A.; Schönenberger, M.; Shchutska, L.; Tavolaro, V. R.; Theofilatos, K.; Vesterbacka Olsson, M. L.; Wallny, R.; Zhu, D. H.; Aarrestad, T. K.; Amsler, C.; Brzhechko, D.; Canelli, M. F.; De Cosa, A.; Del Burgo, R.; Donato, S.; Galloni, C.; Hreus, T.; Kilminster, B.; Neutelings, I.; Pinna, D.; Rauco, G.; Robmann, P.; Salerno, D.; Schweiger, K.; Seitz, C.; Takahashi, Y.; Zucchetta, A.; Candelise, V.; Chang, Y. H.; Cheng, K. y.; Doan, T. H.; Jain, Sh.; Khurana, R.; Kuo, C. M.; Lin, W.; Pozdnyakov, A.; Yu, S. S.; Kumar, Arun; Chang, P.; Chao, Y.; Chen, K. F.; Chen, P. H.; Fiori, F.; Hou, W.-S.; Hsiung, Y.; Liu, Y. F.; Lu, R.-S.; Paganis, E.; Psallidas, A.; Steen, A.; Tsai, J. f.; Asavapibhop, B.; Kovitanggoon, K.; Singh, G.; Srimanobhas, N.; Bakirci, M. N.; Bat, A.; Boran, F.; Damarseckin, S.; Demiroglu, Z. S.; Dozen, C.; Eskut, E.; Girgis, S.; Gokbulut, G.; Guler, Y.; Hos, I.; Kangal, E. E.; Kara, O.; Kiminsu, U.; Oglakci, M.; Onengut, G.; Ozdemir, K.; Ozturk, S.; Polatoz, A.; Sunar Cerci, D.; Tok, U. G.; Turkcapar, S.; Zorbakir, I. S.; Zorbilmez, C.; Karapinar, G.; Ocalan, K.; Yalvac, M.; Zeyrek, M.; Atakisi, I. O.; Gülmez, E.; Kaya, M.; Kaya, O.; Tekten, S.; Yetkin, E. A.; Agaras, M. N.; Atay, S.; Cakir, A.; Cankocak, K.; Komurcu, Y.; Grynyov, B.; Levchuk, L.; Ball, F.; Beck, L.; Brooke, J. J.; Burns, D.; Clement, E.; Cussans, D.; Davignon, O.; Flacher, H.; Goldstein, J.; Heath, G. P.; Heath, H. F.; Kreczko, L.; Newbold, D. M.; Paramesvaran, S.; Sakuma, T.; Seif El Nasr-storey, S.; Smith, D.; Smith, V. J.; Bell, K. W.; Belyaev, A.; Brew, C.; Brown, R. M.; Cieri, D.; Cockerill, D. J. A.; Coughlan, J. A.; Harder, K.; Harper, S.; Linacre, J.; Olaiya, E.; Petyt, D.; Shepherd-Themistocleous, C. H.; Thea, A.; Tomalin, I. R.; Williams, T.; Womersley, W. J.; Auzinger, G.; Bainbridge, R.; Bloch, P.; Borg, J.; Breeze, S.; Buchmuller, O.; Bundock, A.; Casasso, S.; Colling, D.; Corpe, L.; Dauncey, P.; Davies, G.; Della Negra, M.; Di Maria, R.; Haddad, Y.; Hall, G.; Iles, G.; James, T.; Komm, M.; Lane, R.; Laner, C.; Lyons, L.; Magnan, A.-M.; Malik, S.; Mastrolorenzo, L.; Matsushita, T.; Nash, J.; Nikitenko, A.; Palladino, V.; Pesaresi, M.; Richards, A.; Rose, A.; Scott, E.; Seez, C.; Shtipliyski, A.; Strebler, T.; Summers, S.; Tapper, A.; Uchida, K.; Vazquez Acosta, M.; Virdee, T.; Wardle, N.; Winterbottom, D.; Wright, J.; Zenz, S. C.; Cole, J. E.; Hobson, P. R.; Khan, A.; Kyberd, P.; Morton, A.; Reid, I. D.; Teodorescu, L.; Zahid, S.; Borzou, A.; Call, K.; Dittmann, J.; Hatakeyama, K.; Liu, H.; Pastika, N.; Smith, C.; Bartek, R.; Dominguez, A.; Buccilli, A.; Cooper, S. I.; Henderson, C.; Rumerio, P.; West, C.; Arcaro, D.; Avetisyan, A.; Bose, T.; Gastler, D.; Rankin, D.; Richardson, C.; Rohlf, J.; Sulak, L.; Zou, D.; Benelli, G.; Cutts, D.; Hadley, M.; Hakala, J.; Heintz, U.; Hogan, J. M.; Kwok, K. H. M.; Laird, E.; Landsberg, G.; Lee, J.; Mao, Z.; Narain, M.; Pazzini, J.; Piperov, S.; Sagir, S.; Syarif, R.; Yu, D.; Band, R.; Brainerd, C.; Breedon, R.; Burns, D.; Calderon De La Barca Sanchez, M.; Chertok, M.; Conway, J.; Conway, R.; Cox, P. T.; Erbacher, R.; Flores, C.; Funk, G.; Ko, W.; Lander, R.; Mclean, C.; Mulhearn, M.; Pellett, D.; Pilot, J.; Shalhout, S.; Shi, M.; Smith, J.; Stolp, D.; Taylor, D.; Tos, K.; Tripathi, M.; Wang, Z.; Zhang, F.; Bachtis, M.; Bravo, C.; Cousins, R.; Dasgupta, A.; Florent, A.; Hauser, J.; Ignatenko, M.; Mccoll, N.; Regnard, S.; Saltzberg, D.; Schnaible, C.; Valuev, V.; Bouvier, E.; Burt, K.; Clare, R.; Ellison, J.; Gary, J. W.; Ghiasi Shirazi, S. M. A.; Hanson, G.; Karapostoli, G.; Kennedy, E.; Lacroix, F.; Long, O. R.; Olmedo Negrete, M.; Paneva, M. I.; Si, W.; Wang, L.; Wei, H.; Wimpenny, S.; Yates, B. R.; Branson, J. G.; Cittolin, S.; Derdzinski, M.; Gerosa, R.; Gilbert, D.; Hashemi, B.; Holzner, A.; Klein, D.; Kole, G.; Krutelyov, V.; Letts, J.; Masciovecchio, M.; Olivito, D.; Padhi, S.; Pieri, M.; Sani, M.; Sharma, V.; Simon, S.; Tadel, M.; Vartak, A.; Wasserbaech, S.; Wood, J.; Würthwein, F.; Yagil, A.; Zevi Della Porta, G.; Amin, N.; Bhandari, R.; Bradmiller-Feld, J.; Campagnari, C.; Citron, M.; Dishaw, A.; Dutta, V.; Franco Sevilla, M.; Gouskos, L.; Heller, R.; Incandela, J.; Ovcharova, A.; Qu, H.; Richman, J.; Stuart, D.; Suarez, I.; Yoo, J.; Anderson, D.; Bornheim, A.; Bunn, J.; Lawhorn, J. M.; Newman, H. B.; Nguyen, T. Q.; Pena, C.; Spiropulu, M.; Vlimant, J. R.; Wilkinson, R.; Xie, S.; Zhang, Z.; Zhu, R. Y.; Andrews, M. B.; Ferguson, T.; Mudholkar, T.; Paulini, M.; Russ, J.; Sun, M.; Vogel, H.; Vorobiev, I.; Weinberg, M.; Cumalat, J. P.; Ford, W. T.; Jensen, F.; Johnson, A.; Krohn, M.; Leontsinis, S.; MacDonald, E.; Mulholland, T.; Stenson, K.; Ulmer, K. A.; Wagner, S. R.; Alexander, J.; Chaves, J.; Cheng, Y.; Chu, J.; Datta, A.; Mcdermott, K.; Mirman, N.; Patterson, J. R.; Quach, D.; Rinkevicius, A.; Ryd, A.; Skinnari, L.; Soffi, L.; Tan, S. M.; Tao, Z.; Thom, J.; Tucker, J.; Wittich, P.; Zientek, M.; Abdullin, S.; Albrow, M.; Alyari, M.; Apollinari, G.; Apresyan, A.; Apyan, A.; Banerjee, S.; Bauerdick, L. A. T.; Beretvas, A.; Berryhill, J.; Bhat, P. C.; Bolla, G.; Burkett, K.; Butler, J. N.; Canepa, A.; Cerati, G. B.; Cheung, H. W. K.; Chlebana, F.; Cremonesi, M.; Duarte, J.; Elvira, V. D.; Freeman, J.; Gecse, Z.; Gottschalk, E.; Gray, L.; Green, D.; Grünendahl, S.; Gutsche, O.; Hanlon, J.; Harris, R. M.; Hasegawa, S.; Hirschauer, J.; Hu, Z.; Jayatilaka, B.; Jindariani, S.; Johnson, M.; Joshi, U.; Klima, B.; Kortelainen, M. J.; Kreis, B.; Lammel, S.; Lincoln, D.; Lipton, R.; Liu, M.; Liu, T.; Lopes De Sá, R.; Lykken, J.; Maeshima, K.; Magini, N.; Marraffino, J. M.; Mason, D.; McBride, P.; Merkel, P.; Mrenna, S.; Nahn, S.; O'Dell, V.; Pedro, K.; Prokofyev, O.; Rakness, G.; Ristori, L.; Savoy-Navarro, A.; Schneider, B.; Sexton-Kennedy, E.; Soha, A.; Spalding, W. J.; Spiegel, L.; Stoynev, S.; Strait, J.; Strobbe, N.; Taylor, L.; Tkaczyk, S.; Tran, N. V.; Uplegger, L.; Vaandering, E. W.; Vernieri, C.; Verzocchi, M.; Vidal, R.; Wang, M.; Weber, H. A.; Whitbeck, A.; Wu, W.; Acosta, D.; Avery, P.; Bortignon, P.; Bourilkov, D.; Brinkerhoff, A.; Carnes, A.; Carver, M.; Curry, D.; Field, R. D.; Furic, I. K.; Gleyzer, S. V.; Joshi, B. M.; Konigsberg, J.; Korytov, A.; Kotov, K.; Ma, P.; Matchev, K.; Mei, H.; Mitselmakher, G.; Shi, K.; Sperka, D.; Terentyev, N.; Thomas, L.; Wang, J.; Wang, S.; Yelton, J.; Joshi, Y. R.; Linn, S.; Markowitz, P.; Rodriguez, J. L.; Ackert, A.; Adams, T.; Askew, A.; Hagopian, S.; Hagopian, V.; Johnson, K. F.; Kolberg, T.; Martinez, G.; Perry, T.; Prosper, H.; Saha, A.; Santra, A.; Sharma, V.; Yohay, R.; Baarmand, M. M.; Bhopatkar, V.; Colafranceschi, S.; Hohlmann, M.; Noonan, D.; Roy, T.; Yumiceva, F.; Adams, M. R.; Apanasevich, L.; Berry, D.; Betts, R. R.; Cavanaugh, R.; Chen, X.; Dittmer, S.; Evdokimov, O.; Gerber, C. E.; Hangal, D. A.; Hofman, D. J.; Jung, K.; Kamin, J.; Sandoval Gonzalez, I. D.; Tonjes, M. B.; Varelas, N.; Wang, H.; Wu, Z.; Zhang, J.; Bilki, B.; Clarida, W.; Dilsiz, K.; Durgut, S.; Gandrajula, R. P.; Haytmyradov, M.; Khristenko, V.; Merlo, J.-P.; Mermerkaya, H.; Mestvirishvili, A.; Moeller, A.; Nachtman, J.; Ogul, H.; Onel, Y.; Ozok, F.; Penzo, A.; Snyder, C.; Tiras, E.; Wetzel, J.; Yi, K.; Blumenfeld, B.; Cocoros, A.; Eminizer, N.; Fehling, D.; Feng, L.; Gritsan, A. V.; Hung, W. T.; Maksimovic, P.; Roskes, J.; Sarica, U.; Swartz, M.; Xiao, M.; You, C.; Al-bataineh, A.; Baringer, P.; Bean, A.; Boren, S.; Bowen, J.; Castle, J.; Khalil, S.; Kropivnitskaya, A.; Majumder, D.; Mcbrayer, W.; Murray, M.; Rogan, C.; Royon, C.; Sanders, S.; Schmitz, E.; Tapia Takaki, J. D.; Wang, Q.; Ivanov, A.; Kaadze, K.; Maravin, Y.; Modak, A.; Mohammadi, A.; Saini, L. K.; Skhirtladze, N.; Rebassoo, F.; Wright, D.; Baden, A.; Baron, O.; Belloni, A.; Eno, S. C.; Feng, Y.; Ferraioli, C.; Hadley, N. J.; Jabeen, S.; Jeng, G. Y.; Kellogg, R. G.; Kunkle, J.; Mignerey, A. C.; Ricci-Tam, F.; Shin, Y. H.; Skuja, A.; Tonwar, S. C.; Abercrombie, D.; Allen, B.; Azzolini, V.; Barbieri, R.; Baty, A.; Bauer, G.; Bi, R.; Brandt, S.; Busza, W.; Cali, I. A.; D'Alfonso, M.; Demiragli, Z.; Gomez Ceballos, G.; Goncharov, M.; Harris, P.; Hsu, D.; Hu, M.; Iiyama, Y.; Innocenti, G. M.; Klute, M.; Kovalskyi, D.; Lee, Y.-J.; Levin, A.; Luckey, P. D.; Maier, B.; Marini, A. C.; Mcginn, C.; Mironov, C.; Narayanan, S.; Niu, X.; Paus, C.; Roland, C.; Roland, G.; Stephans, G. S. F.; Sumorok, K.; Tatar, K.; Velicanu, D.; Wang, J.; Wang, T. W.; Wyslouch, B.; Zhaozhong, S.; Benvenuti, A. C.; Chatterjee, R. M.; Evans, A.; Hansen, P.; Kalafut, S.; Kubota, Y.; Lesko, Z.; Mans, J.; Nourbakhsh, S.; Ruckstuhl, N.; Rusack, R.; Turkewitz, J.; Wadud, M. A.; Acosta, J. G.; Oliveros, S.; Avdeeva, E.; Bloom, K.; Claes, D. R.; Fangmeier, C.; Golf, F.; Gonzalez Suarez, R.; Kamalieddin, R.; Kravchenko, I.; Monroy, J.; Siado, J. E.; Snow, G. R.; Stieger, B.; Godshalk, A.; Harrington, C.; Iashvili, I.; Nguyen, D.; Parker, A.; Rappoccio, S.; Roozbahani, B.; Alverson, G.; Barberis, E.; Freer, C.; Hortiangtham, A.; Massironi, A.; Morse, D. M.; Orimoto, T.; Teixeira De Lima, R.; Wamorkar, T.; Wang, B.; Wisecarver, A.; Wood, D.; Bhattacharya, S.; Charaf, O.; Hahn, K. A.; Mucia, N.; Odell, N.; Schmitt, M. H.; Sung, K.; Trovato, M.; Velasco, M.; Bucci, R.; Dev, N.; Hildreth, M.; Hurtado Anampa, K.; Jessop, C.; Karmgard, D. J.; Kellams, N.; Lannon, K.; Li, W.; Loukas, N.; Marinelli, N.; Meng, F.; Mueller, C.; Musienko, Y.; Planer, M.; Reinsvold, A.; Ruchti, R.; Siddireddy, P.; Smith, G.; Taroni, S.; Wayne, M.; Wightman, A.; Wolf, M.; Woodard, A.; Alimena, J.; Antonelli, L.; Bylsma, B.; Durkin, L. S.; Flowers, S.; Francis, B.; Hart, A.; Hill, C.; Ji, W.; Ling, T. Y.; Luo, W.; Winer, B. L.; Wulsin, H. W.; Cooperstein, S.; Driga, O.; Elmer, P.; Hardenbrook, J.; Hebda, P.; Higginbotham, S.; Kalogeropoulos, A.; Lange, D.; Luo, J.; Marlow, D.; Mei, K.; Ojalvo, I.; Olsen, J.; Palmer, C.; Piroué, P.; Salfeld-Nebgen, J.; Stickland, D.; Tully, C.; Malik, S.; Norberg, S.; Barker, A.; Barnes, V. E.; Das, S.; Gutay, L.; Jones, M.; Jung, A. W.; Khatiwada, A.; Miller, D. H.; Neumeister, N.; Peng, C. C.; Qiu, H.; Schulte, J. F.; Sun, J.; Wang, F.; Xiao, R.; Xie, W.; Cheng, T.; Dolen, J.; Parashar, N.; Chen, Z.; Ecklund, K. M.; Freed, S.; Geurts, F. J. M.; Guilbaud, M.; Kilpatrick, M.; Li, W.; Michlin, B.; Padley, B. P.; Roberts, J.; Rorie, J.; Shi, W.; Tu, Z.; Zabel, J.; Zhang, A.; Bodek, A.; de Barbaro, P.; Demina, R.; Duh, Y. t.; Ferbel, T.; Galanti, M.; Garcia-Bellido, A.; Han, J.; Hindrichs, O.; Khukhunaishvili, A.; Lo, K. H.; Tan, P.; Verzetti, M.; Ciesielski, R.; Goulianos, K.; Mesropian, C.; Agapitos, A.; Chou, J. P.; Gershtein, Y.; Gómez Espinosa, T. A.; Halkiadakis, E.; Heindl, M.; Hughes, E.; Kaplan, S.; Kunnawalkam Elayavalli, R.; Kyriacou, S.; Lath, A.; Montalvo, R.; Nash, K.; Osherson, M.; Saka, H.; Salur, S.; Schnetzer, S.; Sheffield, D.; Somalwar, S.; Stone, R.; Thomas, S.; Thomassen, P.; Walker, M.; Delannoy, A. G.; Heideman, J.; Riley, G.; Rose, K.; Spanier, S.; Thapa, K.; Bouhali, O.; Castaneda Hernandez, A.; Celik, A.; Dalchenko, M.; De Mattia, M.; Delgado, A.; Dildick, S.; Eusebi, R.; Gilmore, J.; Huang, T.; Kamon, T.; Mueller, R.; Pakhotin, Y.; Patel, R.; Perloff, A.; Perniè, L.; Rathjens, D.; Safonov, A.; Tatarinov, A.; Akchurin, N.; Damgov, J.; De Guio, F.; Dudero, P. R.; Faulkner, J.; Gurpinar, E.; Kunori, S.; Lamichhane, K.; Lee, S. W.; Mengke, T.; Muthumuni, S.; Peltola, T.; Undleeb, S.; Volobouev, I.; Wang, Z.; Greene, S.; Gurrola, A.; Janjam, R.; Johns, W.; Maguire, C.; Melo, A.; Ni, H.; Padeken, K.; Ruiz Alvarez, J. D.; Sheldon, P.; Tuo, S.; Velkovska, J.; Xu, Q.; Arenton, M. W.; Barria, P.; Cox, B.; Hirosky, R.; Joyce, M.; Ledovskoy, A.; Li, H.; Neu, C.; Sinthuprasith, T.; Wang, Y.; Wolfe, E.; Xia, F.; Harr, R.; Karchin, P. E.; Poudyal, N.; Sturdy, J.; Thapa, P.; Zaleski, S.; Brodski, M.; Buchanan, J.; Caillol, C.; Carlsmith, D.; Dasu, S.; Dodd, L.; Duric, S.; Gomber, B.; Grothe, M.; Herndon, M.; Hervé, A.; Hussain, U.; Klabbers, P.; Lanaro, A.; Levine, A.; Long, K.; Loveless, R.; Rekovic, V.; Ruggles, T.; Savin, A.; Smith, N.; Smith, W. H.; Woods, N.

2018-05-01

A search for a heavy right-handed W boson (WR) decaying to a heavy right-handed neutrino and a charged lepton in events with two same-flavor leptons (e or μ) and two jets, is presented. The analysis is based on proton-proton collision data, collected by the CMS Collaboration at the LHC in 2016 and corresponding to an integrated luminosity of 35.9 fb-1. No significant excess above the standard model expectation is seen in the invariant mass distribution of the dilepton plus dijet system. Assuming that couplings are identical to those of the standard model, and that only one heavy neutrino flavor NR contributes significantly to the WR decay width, the region in the two-dimensional ({m}_{{W}R},{m}_{{N}R}) mass plane excluded at 95% confidence level extends to approximately {m}_{{W}R}=4.4 TeV and covers a large range of right-handed neutrino masses below the WR boson mass. This analysis provides the most stringent limits on the WR mass to date. [Figure not available: see fulltext.

X-RAY EMISSION FROM THE WOLF-RAYET BUBBLE S 308

DOE Office of Scientific and Technical Information (OSTI.GOV)

Toala, J. A.; Guerrero, M. A.; Chu, Y.-H.

The Wolf-Rayet (WR) bubble S 308 around the WR star HD 50896 is one of the only two WR bubbles known to possess X-ray emission. We present XMM-Newton observations of three fields of this WR bubble that, in conjunction with an existing observation of its northwest quadrant, map most of the nebula. The X-ray emission from S 308 displays a limb-brightened morphology, with a central cavity {approx}22' in size and a shell thickness of {approx}8'. This X-ray shell is confined by the optical shell of ionized material. The spectrum is dominated by the He-like triplets of N VI at 0.43more » keV and O VII at 0.57 keV, and declines toward high energies, with a faint tail up to 1 keV. This spectrum can be described by a two-temperature optically thin plasma emission model (T{sub 1} {approx} 1.1 Multiplication-Sign 10{sup 6} K, T{sub 2} {approx} 13 Multiplication-Sign 10{sup 6} K), with a total X-ray luminosity {approx}2 Multiplication-Sign 10{sup 33} erg s{sup -1} at the assumed distance of 1.5 kpc.« less

A case of "order insensitivity"? Natural and artificial language processing in a man with primary progressive aphasia.

PubMed

Zimmerer, Vitor C; Varley, Rosemary A

2015-08-01

Processing of linear word order (linear configuration) is important for virtually all languages and essential to languages such as English which have little functional morphology. Damage to systems underpinning configurational processing may specifically affect word-order reliant sentence structures. We explore order processing in WR, a man with primary progressive aphasia (PPA). In a previous report, we showed how WR showed impaired processing of actives, which rely strongly on word order, but not passives where functional morphology signals thematic roles. Using the artificial grammar learning (AGL) paradigm, we examined WR's ability to process order in non-verbal, visual sequences and compared his profile to that of healthy controls, and aphasic participants with and without severe syntactic disorder. Results suggested that WR, like some other patients with severe syntactic impairment, was unable to detect linear configurational structure. The data are consistent with the notion that disruption of possibly domain-general linearization systems differentially affects processing of active and passive sentence structures. Further research is needed to test this account, and we suggest hypotheses for future studies. Copyright © 2015 Elsevier Ltd. All rights reserved.

The Multiplicity of Wolf-Rayet Stars

NASA Technical Reports Server (NTRS)

Wallace, Debra J.

2004-01-01

The most massive stars drastically reconfigure their surroundings via their strong stellar winds and powerful ionizing radiation. With this mass fueling their large luminosities, these stars are frequently used as standard candles in distance determination, and as tracers of stellar evolution in different regions and epochs. In their dieing burst, some of the once massive stars will enter a Wolf-Rayet (WR) phase lasting approx.10% of the stellar lifetime. This phase is particularly useful for study because these stars have strong spectroscopic signatures that allow them to be easily identified at great distances. But how accurate are these identifications? Increasingly, the relatively nearby stars we once assumed to be single are revealing themselves to be binary or multiple. New techniques, such as high-resolution imaging and interferometry, are changing our knowledge of these objects. I will discuss recent results in the literature and how this affects the binary distribution of WR stars. I will also discuss the implications of binary vs. single star evolution on evolution through the WR phase. Finally, I will discuss the implications of these revised numbers on both massive stellar evolution itself, and the impact that this has on the role of WR stars as calibrators.

Role of sulfatide in vaccinia virus infection.

PubMed

Perino, Julien; Foo, Chwan Hong; Spehner, Daniele; Cohen, Gary H; Eisenberg, Roselyn J; Crance, Jean-Marc; Favier, Anne-Laure

2011-07-01

Vaccinia virus (VACV) was used as a surrogate of variola virus (genus Orthopoxvirus), the causative agent of smallpox, to study orthopoxvirus infection. VACV infects cells via attachment and fusion of the viral membrane with the host cell membrane. Glycosphingolipids, expressed in multiple organs, are major components of lipid rafts and have been associated with the infectious route of several pathogens. We demonstrate that the VACV-WR (VACV Western-Reserve strain) displays no binding to Cer (ceramide) or to Gal-Cer (galactosylceramide), but binds to a natural sulfated derivative of these molecules: the Sulf (sulfatide) 3' sulfogalactosylceramide. The interaction between Sulf and VACV-WR resulted in a time-dependent inhibition of virus infection. Virus cell attachment was the crucial step inhibited by Sulf. Electron microscopy showed that SUVs (small unilamellar vesicles) enriched in Sulf bound to VACV particles. Both the A27 and L5 viral membrane proteins were shown to interact with Sulf, indicating that they could be the major viral ligands for Sulf. Soluble Sulf was successful in preventing mortality, but not morbidity, in a lethal mouse model infection with VACV-WR. Together the results suggest that Sulf could play a role as an alternate receptor for VACV-WR and probably other Orthopoxviruses.

Applications of machine-learning algorithms for infrared colour selection of Galactic Wolf-Rayet stars

NASA Astrophysics Data System (ADS)

Morello, Giuseppe; Morris, P. W.; Van Dyk, S. D.; Marston, A. P.; Mauerhan, J. C.

2018-01-01

We have investigated and applied machine-learning algorithms for infrared colour selection of Galactic Wolf-Rayet (WR) candidates. Objects taken from the Spitzer Galactic Legacy Infrared Midplane Survey Extraordinaire (GLIMPSE) catalogue of the infrared objects in the Galactic plane can be classified into different stellar populations based on the colours inferred from their broad-band photometric magnitudes [J, H and Ks from 2 Micron All Sky Survey (2MASS), and the four Spitzer/IRAC bands]. The algorithms tested in this pilot study are variants of the k-nearest neighbours approach, which is ideal for exploratory studies of classification problems where interrelations between variables and classes are complicated. The aims of this study are (1) to provide an automated tool to select reliable WR candidates and potentially other classes of objects, (2) to measure the efficiency of infrared colour selection at performing these tasks and (3) to lay the groundwork for statistically inferring the total number of WR stars in our Galaxy. We report the performance results obtained over a set of known objects and selected candidates for which we have carried out follow-up spectroscopic observations, and confirm the discovery of four new WR stars.

COS-Weak: probing the CGM using analogues of weak Mg II absorbers at z < 0.3

NASA Astrophysics Data System (ADS)

Muzahid, S.; Fonseca, G.; Roberts, A.; Rosenwasser, B.; Richter, P.; Narayanan, A.; Churchill, C.; Charlton, J.

2018-06-01

We present a sample of 34 weak metal line absorbers at z < 0.3 selected by the simultaneous >3σ detections of the Si IIλ1260 and C IIλ1334 absorption lines, with Wr(Si II)<0.2 Å and Wr(C II)<0.3 Å, in archival HST/COS spectra. Our sample increases the number of known low-z `weak absorbers' by a factor of >5. The column densities of H I and low-ionization metal lines obtained from Voigt profile fitting are used to build simple photoionization models. The inferred densities and line-of-sight thicknesses of the absorbers are in the ranges of -3.3 < log nH/cm-3 < -2.4 and ˜1 pc-50 kpc (median ≈500 pc), respectively. Most importantly, 85 per cent (50 per cent) of these absorbers show a metallicity of [Si/H] > -1.0 (0.0). The fraction of systems showing near-/supersolar metallicity in our sample is significantly higher than in the H I-selected sample of Wotta et al., and the galaxy-selected sample of Prochaska et al., of absorbers probing the circum-galactic medium at similar redshift. A search for galaxies has revealed a significant galaxy-overdensity around these weak absorbers compared to random positions with a median impact parameter of 166 kpc from the nearest galaxy. Moreover, we find the presence of multiple galaxies in ≈80 per cent of the cases, suggesting group environments. The observed dN/dz of 0.8 ± 0.2 indicates that such metal-enriched, compact, dense structures are ubiquitous in the haloes of low-z group galaxies. We suggest that these are transient structures that are related to galactic outflows and/or stripping of metal-rich gas from galaxies.

Physical properties of the WR stars in Westerlund 1

NASA Astrophysics Data System (ADS)

Rosslowe, C. K.; Crowther, P. A.; Clark, J. S.; Negueruela, I.

The Westerlund 1 (Wd1) cluster hosts a rich and varied collection of massive stars. Its dynamical youth and the absence of ongoing star formation indicate a coeval population. As such, the simultaneous presence of both late-type supergiants and Wolf-Rayet stars has defied explanation in the context of single-star evolution. Observational evidence points to a high binary fraction, hence this stellar population offers a robust test for stellar models accounting for both single-star and binary evolution. We present an optical to near-IR (VLT & NTT) spectroscopic analysis of 22 WR stars in Wd 1, delivering physical properties for the WR stars. We discuss how these differ from the Galactic field population, and how they may be reconciled with the predictions of single and binary evolutionary models.

Machine-learning approaches to select Wolf-Rayet candidates

NASA Astrophysics Data System (ADS)

Marston, A. P.; Morello, G.; Morris, P.; van Dyk, S.; Mauerhan, J.

2017-11-01

The WR stellar population can be distinguished, at least partially, from other stellar populations by broad-band IR colour selection. We present the use of a machine learning classifier to quantitatively improve the selection of Galactic Wolf-Rayet (WR) candidates. These methods are used to separate the other stellar populations which have similar IR colours. We show the results of the classifications obtained by using the 2MASS J, H and K photometric bands, and the Spitzer/IRAC bands at 3.6, 4.5, 5.8 and 8.0μm. The k-Nearest Neighbour method has been used to select Galactic WR candidates for observational follow-up. A few candidates have been spectroscopically observed. Preliminary observations suggest that a detection rate of 50% can easily be achieved.

Determination of the radioprotective effects of topical applications of MEA, WR-2721, and N-acetylcysteine on murine skin

DOE Office of Scientific and Technical Information (OSTI.GOV)

Verhey, L.J.; Sedlacek, R.

1983-01-01

Topical applications of MEA (beta-mercaptoethylamine or cysteamine), WR-2721 (S-2-(3-aminopropylamino)-ethylphosphorothioic acid), and N-acetylcysteine (NAC) were tested for their ability to protect the normal skin of the hind legs of mice against acute and late damage from single doses of /sup 137/Cs radiation. No significant protection was observed with either WR-2721 or NAC. MEA was shown to offer significant protection against acute skin damage in both buffered and unbuffered forms, but no significant protection against late contraction. The use of topical MEA on unanesthetized animals breathing carbogen (95% O2, 5% CO2) appears to give an enhanced level of radioprotection over that shownmore » for anesthetized, air-breathing animals.« less

Acyclic High-Energy Variability in Eta Carinae and WR 140

NASA Technical Reports Server (NTRS)

Corcoran, Michael F.

2012-01-01

Eta Carinae and WR 140 are similar long-period colliding wind binaries in which X-ray emission is produced by a strong shock due to the collision of the powerful stellar winds. The change in the orientation and density of this shock as the stars revolve in their orbits influences the X-ray flux and spectrum in a phase dependent way. Monitoring observations with RXTE and other X-ray satellite observatories since the 1990s have detailed this variability but have also shown significant deviations from strict phase dependence (short-term brightness changes or "flares", and cyc1e-to-cyc1e average flux differences). We examine these acylic variations in Eta Car and WR 140 and discuss what they tell us about the stability of the wind-wind collision shock.

Natto and viscous vegetables in a Japanese-style breakfast improved insulin sensitivity, lipid metabolism and oxidative stress in overweight subjects with impaired glucose tolerance.

PubMed

Taniguchi-Fukatsu, Akiko; Yamanaka-Okumura, Hisami; Naniwa-Kuroki, Yuko; Nishida, Yuka; Yamamoto, Hironori; Taketani, Yutaka; Takeda, Eiji

2012-04-01

We previously suggested that the consumption of natto and viscous vegetables as part of a Japanese-style meal based on white rice (WR) reduced postprandial glucose and insulin levels in healthy subjects. The aim of the present study was to assess whether a single breakfast of natto and viscous vegetables or the same breakfast consumed for 2 weeks could improve glucose control, insulin sensitivity, lipid metabolism and oxidative stress in overweight subjects with impaired glucose tolerance (IGT). A total of eleven free-living subjects with IGT followed a randomised, crossover breakfast intervention for 2 weeks. The test meal included boiled WR with natto (viscous fermented soyabeans), Japanese yam and okra. The control meal included WR with non-viscous boiled soyabeans, potatoes and broccoli. Both meals contained comparable amounts of carbohydrate, fat, protein and fibre. The test meal reduced acute glucose and insulin responses compared to the control meal in the study participants. Insulin sensitivity was assessed using the composite insulin sensitivity index (CISI) after both the test and control meal periods. The test meal resulted in improvements in CISI compared to the baseline, whereas no significant changes were observed after the control meal period. Serum levels of both total and LDL-cholesterol were assessed before and after the test meal period and found to decrease significantly. There was also a tendency towards reduced serum malondialdehyde-modified LDL and N(ɛ)-carboxymethyllysine. No differences were observed in the measures of chronic glycaemic control. Thus, we conclude that a breakfast of natto and viscous vegetables consumed for 2 weeks improves insulin sensitivity, serum lipid and oxidative stress.

Insights into Gulf of Mexico Gas Hydrate Study Sites GC955 and WR313 from New Multicomponent and High-Resolution 2D Seismic Data

NASA Astrophysics Data System (ADS)

Haines, S. S.; Hart, P. E.; Collett, T. S.; Shedd, W. W.; Frye, M.

2014-12-01

In 2013, the U.S. Geological Survey led a seismic acquisition expedition in the Gulf of Mexico, acquiring multicomponent data and high-resolution 2D multichannel seismic (MCS) data at Green Canyon 955 (GC955) and Walker Ridge 313 (WR313). Based on previously collected logging-while-drilling (LWD) borehole data, these gas hydrate study sites are known to include high concentrations of gas hydrate within sand layers. At GC955 our new 2D data reveal at least three features that appear to be fluid-flow pathways (chimneys) responsible for gas migration and thus account for some aspects of the gas hydrate distribution observed in the LWD data. Our new data also show that the main gas hydrate target, a Pleistocene channel/levee complex, has an areal extent of approximately 5.5 square kilometers and that a volume of approximately 3 x 107 cubic meters of this body lies within the gas hydrate stability zone. Based on LWD-inferred values and reasonable assumptions for net sand, sand porosity, and gas hydrate saturation, we estimate a total equivalent gas-in-place volume of approximately 8 x 108 cubic meters for the inferred gas hydrate within the channel/levee deposits. At WR313 we are able to map the thin hydrate-bearing sand layers in considerably greater detail than that provided by previous data. We also can map the evolving and migrating channel feature that persists in this area. Together these data and the emerging results provide valuable new insights into the gas hydrate systems at these two sites.

Radiographic abnormalities and exposure to asbestos-contaminated vermiculite in the community of Libby, Montana, USA.

PubMed

Peipins, Lucy A; Lewin, Michael; Campolucci, Sharon; Lybarger, Jeffrey A; Miller, Aubrey; Middleton, Dan; Weis, Christopher; Spence, Michael; Black, Brad; Kapil, Vikas

2003-11-01

Mining, handling, processing, and personal or commercial use of asbestos-contaminated vermiculite have led to widespread contamination of the Libby, Montana, area. We initiated a medical testing program in response to reports of respiratory illness in the community. The purpose of this analysis was to identify and quantify asbestos-related radiographic abnormalities among persons exposed to vermiculite in Libby and to examine associations between these outcomes and participants' self-reported exposures. A cross-sectional interview and medical testing were conducted in Libby from July through November 2000 and from July through September 2001. A total of 7,307 persons who had lived, worked, or played in Libby for at least 6 months before 31 December 1990 completed the interview. Of those, 6,668 participants > or = 18 years of age received chest radiographs to assess the prevalence of pleural and interstitial abnormalities. We observed pleural abnormalities in 17.8% of participants and interstitial abnormalities in < 1% of participants undergoing chest radiography. We examined 29 occupational, recreational, household, and other exposure pathways in the analysis. The prevalence of pleural abnormalities increased with increasing number of exposure pathways, ranging from 6.7% for those who reported no apparent exposures to 34.6% for those who reported > or = 12 pathways. The factors most strongly associated with pleural abnormalities were being a former W.R. Grace worker, being older, having been a household contact of a W.R. Grace worker, and being a male. In addition to being a former W.R. Grace worker, environmental exposures and other nonoccupational risk factors were also important predictors of asbestos-related radiographic abnormalities.

Mouse genetics and proteomic analyses demonstrate a critical role for complement in a model of DHRD/ML, an inherited macular degeneration

PubMed Central

Garland, Donita L.; Fernandez-Godino, Rosario; Kaur, Inderjeet; Speicher, Kaye D.; Harnly, James M.; Lambris, John D.; Speicher, David W.; Pierce, Eric A.

2014-01-01

Macular degenerations, inherited and age related, are important causes of vision loss. Human genetic studies have suggested perturbation of the complement system is important in the pathogenesis of age-related macular degeneration. The mechanisms underlying the involvement of the complement system are not understood, although complement and inflammation have been implicated in drusen formation. Drusen are an early clinical hallmark of inherited and age-related forms of macular degeneration. We studied one of the earliest stages of macular degeneration which precedes and leads to the formation of drusen, i.e. the formation of basal deposits. The studies were done using a mouse model of the inherited macular dystrophy Doyne Honeycomb Retinal Dystrophy/Malattia Leventinese (DHRD/ML) which is caused by a p.Arg345Trp mutation in EFEMP1. The hallmark of DHRD/ML is the formation of drusen at an early age, and gene targeted Efemp1R345W/R345W mice develop extensive basal deposits. Proteomic analyses of Bruch's membrane/choroid and Bruch's membrane in the Efemp1R345W/R345W mice indicate that the basal deposits comprise normal extracellular matrix (ECM) components present in abnormal amounts. The proteomic analyses also identified significant changes in proteins with immune-related function, including complement components, in the diseased tissue samples. Genetic ablation of the complement response via generation of Efemp1R345W/R345W:C3−/− double-mutant mice inhibited the formation of basal deposits. The results demonstrate a critical role for the complement system in basal deposit formation, and suggest that complement-mediated recognition of abnormal ECM may participate in basal deposit formation in DHRD/ML and perhaps other macular degenerations. PMID:23943789

Individual Members of the Cab Gene Family Differ Widely in Fluence Response.

PubMed Central

White, M. J.; Kaufman, L. S.; Horwitz, B. A.; Briggs, W. R.; Thompson, W. F.

1995-01-01

Chlorophyll a/b-binding protein genes (Cab genes) can be extremely sensitive to light. Transcript accumulation following a red light pulse increases with fluence over 8 orders of magnitude (L.S. Kaufman, W.F. Thompson, W.R. Briggs [1984] Science 226: 1447-1449). We have constructed fluence-response curves for individual Cab genes. At least two Cab genes (Cab-8 and AB96) show a very low fluence response to a single red light pulse. In contrast, two other Cab genes (AB80 and AB66) fail to produce detectable transcript following a single pulse of either red or blue light but are expressed in continuous red light. Thus, very low fluence responses and high irradiance responses occur in the same gene family. PMID:12228352

Oxygen uptake kinetics and exercise capacity in children with cystic fibrosis.

PubMed

Fielding, Jeremy; Brantley, Lucy; Seigler, Nichole; McKie, Katie T; Davison, Gareth W; Harris, Ryan A

2015-07-01

Exercise capacity, an objective measure of exercise intolerance, is known to predict quality of life and mortality in cystic fibrosis (CF). The mechanisms for exercise intolerance in patients with cystic fibrosis (CF), however, have yet to be fully elucidated. Accordingly, this study sought to investigate oxygen uptake kinetics and the impact of fat-free mass (FFM) on exercise capacity in young patients with CF. 16 young patients with CF (age 13 ± 4 years; 10 female) and 15 matched controls (age 14 ± 3 years; nine female) participated. Pulmonary function and a maximal exercise test on a cycle ergometer using the Godfrey protocol were performed. Exercise capacity (VO2 peak), VO2 response time (VO2 RT), and functional VO2 gain (ΔVO2 /ΔWR) were all determined. Lung function was the only demographic parameter significantly lower (P < 0.05) in CF compared to controls. Exercise capacity was lower in CF (P < 0.014) only when VO2 peak was normalized for FFM (43.5 ± 7.7 vs. 50.6 ± 7.4 ml/kg-FFM/min) or expressed as % predicted (70.1 ± 14.3 vs. 85.4 ± 16.0%). The VO2 RT was slower (36.1 ± 15.1 vs. 25.0 ± 12.4 sec; P = 0.03) and the ΔVO2 /ΔWR slope was lower (8.4 ± 3 ml/min/watt vs. 10.1 ± 1.4 ml/min/watt; P = 0.02) in patients compared to controls, respectively. In conclusion, a delayed VO2 response time coupled with the lower functional VO2 gain (ΔVO2 /ΔWR) suggest that young patients with CF have impairment in oxygen transport and oxygen utilization by the muscles. These data in addition to differences in VO2 peak normalized for FFM provide some insight that muscle mass and muscle metabolism contribute to exercise intolerance in CF. © 2015 Wiley Periodicals, Inc.

27 CFR 9.89 - Umpqua Valley.

Code of Federal Regulations, 2012 CFR

2012-04-01

... approximately .33 miles, rejoining the 1,000-foot contour line; thence in a northerly and eventually a southerly.../R7W; thence south along the R6W/R7W range line approximately .5 miles back to the 1,000-foot contour... north along range line R3W/R4W approximately 2.25 miles, back to the 1,000-foot contour line; (9) Thence...

27 CFR 9.89 - Umpqua Valley.

Code of Federal Regulations, 2014 CFR

2014-04-01

... approximately .33 miles, rejoining the 1,000-foot contour line; thence in a northerly and eventually a southerly.../R7W; thence south along the R6W/R7W range line approximately .5 miles back to the 1,000-foot contour... north along range line R3W/R4W approximately 2.25 miles, back to the 1,000-foot contour line; (9) Thence...

27 CFR 9.89 - Umpqua Valley.

Code of Federal Regulations, 2013 CFR

2013-04-01

... approximately .33 miles, rejoining the 1,000-foot contour line; thence in a northerly and eventually a southerly.../R7W; thence south along the R6W/R7W range line approximately .5 miles back to the 1,000-foot contour... north along range line R3W/R4W approximately 2.25 miles, back to the 1,000-foot contour line; (9) Thence...

Effects of sprint interval training and body weight reduction on power to weight ratio in experienced cyclists.

PubMed

Lunn, William R; Finn, Joan A; Axtell, Robert S

2009-07-01

The purpose of this study was to determine the effect of supramaximal sprint interval training (SIT), body weight reduction, and a combination of both treatments on peak and average anaerobic power to weight ratio (PPOan:Wt, APOan:Wt) by manipulating peak and average anaerobic power output (PPOan, APOan) and body weight (BW) in experienced cyclists. Participants (N = 34, age = 38.0 +/- 7.1 years) were assigned to 4 groups for a 10-week study. One group performed twice-weekly SIT sessions on a cycle ergometer while maintaining body weight (SIT). A second group did not perform SIT but intentionally reduced body weight (WR). A third group simultaneously performed SIT sessions and reduced body weight (SIT+WR). A control group cycled in their normal routine and maintained body weight (CON). The 30-second Wingate Test assessed pretest and posttest POan:Wt scores. There was a significant mean increase (p < 0.05) from pretest to posttest in PPOan:Wt and APOan:Wt (W x kg(-1)) scores in both SIT (10.82 +/- 1.71 to 11.92 +/- 1.77 and 8.05 +/- 0.64 to 8.77 +/- 0.64, respectively) and WR (10.33 +/- 2.91 to 11.29 +/- 2.80 and 7.04 +/- 1.45 to 7.62 +/- 1.24, respectively). PPOan and APOan (W) increased significantly only in SIT (753.7 +/- 121.0 to 834.3 +/- 150.1 and 561.3 +/- 62.5 to 612.7 +/- 69.0, respectively). Body weight (kg) decreased significantly in WR and SIT + WR (80.3 +/- 13.7 to 75.3 +/- 11.9 and 78.9 +/- 10.8 to 73.4 +/- 10.8, respectively). The results demonstrate that cyclists can use SIT sessions and body weight reduction as singular training interventions to effect significant increases in anaerobic power to weight ratio, which has been correlated to enhanced aerobic cycling performance. However, the treatments were not effective as combined interventions, as there was no significant change in either PPOan:Wt or APOan:Wt in SIT + WR.

Effect of feeding different levels of wheat roti on nutrient utilization and blood metabolite profile in semi-captive Asian elephants (Elephas maximus).

PubMed

Das, A; Saini, M; Katole, S; Kullu, S S; Swarup, D; Sharma, A K

2015-04-01

This experiment was conducted to study the effect of different levels of wheat roti (WR) on nutrient utilization and blood metabolites in Asian elephants fed roughages ad libitum. Nine (3 M, 6 F) Asian elephants (14-52 years of age, 1909-3968 kg BW) were used in an experiment based on replicated Latin square design. Animals in each group (n = 3) were assigned to one of the three dietary treatments in a manner that animals in all the three groups were exposed to all the three treatments in three different periods. Each feeding trial comprised 30 days (25 days of adaptation and 5 days collection period). The amount of WR fed to the elephants was 0.18, 0.12 and 0.06% of BW in groups I, II and III, respectively. They were allowed to forage in the nearby forests for 6 h/day and to bathe for 2 h/day. The animals had ad libitum access to cut Rohini (Mallotus philippensis) trees in their night shelter. Intake and apparent digestibility of dry matter (DM), crude protein (CP), gross energy (GE), Ca, P, Fe, Cu and Zn were measured. Feed consumption was not significantly different among the groups. Significant (p < 0.01) decrease in digestibility of DM and GE and blood glucose concentration was observed with decreased level of WR in the diet. Feeding of WR at 0.06% of BW supplied adequate amount of DE, CP, Ca, P, Fe, Cu and Zn to meet requirement for adult maintenance. Feeding of WR in excess of 0.06% of BW supplied DE in excess of requirement, increased blood glucose concentration which may cause obesity and other associated health problems. It was concluded that the amount of WR should be restricted to 0.06% of BW in the diet of captive Asian elephants. Journal of Animal Physiology and Animal Nutrition © 2014 Blackwell Verlag GmbH.

Biomarkers of PAH exposure and hematologic effects in subjects exposed to combustion emission during residential (and professional) cooking practices in Pakistan.

PubMed

Kamal, Atif; Cincinelli, Alessandra; Martellini, Tania; Malik, Riffat Naseem

2016-01-01

The aim of this study was to evaluate and compare the exposure of household women and professional male workers to combustion emission in the indoor and semi-outdoor environments, respectively, by using biochemical parameters and the biomarkers of exposure to polycyclic aromatic hydrocarbon (PAH). Female (WR n = 60) and male "cooks" (WC n = 60) exposed to the combustion emission of fuel wood and coal in rural/suburban areas of Pakistan were recruited in this study and compared to non-exposed female (CF) and male (CM) groups (n = 32 and 34, respectively). Urinary biomarkers of PAH exposure including 1-hyroxypyrene (1-OHPyr), α-naphthol, and β-naphthol were analyzed together with the biomarkers of effect, including the serum c-reactive proteins (CRP), white blood cells (WBCs), hemoglobin (Hb), red blood cells (RBC), and platelet (PLT) count. In addition, blood superoxide dismutase (SOD) and urinary level of 8-hydroxydeoxyguanosine (8-OHdG) were evaluated to determine the oxidative stress and DNA damage, respectively. A questionnaire was used to document demographic-, health-, and exposure-related information. The results showed that urinary β-naphthol was almost 44% higher in WR subjects than WC (median 7.69 vs. 3.39 μmol/mol-Cr, respectively; p = 0.01) and respective controls (CF). Higher urinary 8-OHdG were observed in WR (71.1 ng/mg-Cr) than WC (56.37 ng/mg-Cr) (p < 0.001), and lower life status and higher degree of headache were observed in WR than WC. In WCs, however, a low Hb and high WBC (8.29 × 10(3) μL(-1), ranging between 6.1 and 10.6 × 10(3) μL(-1)) were observed in comparison with CM. The study shows that WC subjects used larger amount of fuel and were subjected to prolonged exposure. It was concluded that the role of ventilation is fundamental and WR were more exposed to PAHs despite the fact that WC spent more time in cooking (due to occupational requirement) than WR.

Hyperbolic-cosine waveguide tapers and oversize rectangular waveguide for reduced broadband insertion loss in W-band electron paramagnetic resonance spectroscopy. II. Broadband characterization

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sidabras, Jason W.; Anderson, James R.; Mainali, Laxman

Experimental results have been reported on an oversize rectangular waveguide assembly operating nominally at 94 GHz. It was formed using commercially available WR28 waveguide as well as a pair of specially designed tapers with a hyperbolic-cosine shape from WR28 to WR10 waveguide [R. R. Mett et al., Rev. Sci. Instrum. 82, 074704 (2011)]. The oversize section reduces broadband insertion loss for an Electron Paramagnetic Resonance (EPR) probe placed in a 3.36 T magnet. Hyperbolic-cosine tapers minimize reflection of the main mode and the excitation of unwanted propagating waveguide modes. Oversize waveguide is distinguished from corrugated waveguide, overmoded waveguide, or quasi-opticmore » techniques by minimal coupling to higher-order modes. Only the TE{sub 10} mode of the parent WR10 waveguide is propagated. In the present work, a new oversize assembly with a gradual 90° twist was implemented. Microwave power measurements show that the twisted oversize waveguide assembly reduces the power loss in the observe and pump arms of a W-band bridge by an average of 2.35 dB and 2.41 dB, respectively, over a measured 1.25 GHz bandwidth relative to a straight length of WR10 waveguide. Network analyzer measurements confirm a decrease in insertion loss of 2.37 dB over a 4 GHz bandwidth and show minimal amplitude distortion of approximately 0.15 dB. Continuous wave EPR experiments confirm these results. The measured phase variations of the twisted oversize waveguide assembly, relative to an ideal distortionless transmission line, are reduced by a factor of two compared to a straight length of WR10 waveguide. Oversize waveguide with proper transitions is demonstrated as an effective way to increase incident power and the return signal for broadband EPR experiments. Detailed performance characteristics, including continuous wave experiment using 1 μM 2,2,6,6-tetramethylpiperidine-1-oxyl in aqueous solution, provided here serve as a benchmark for other broadband low-loss probes in millimeter-wave EPR bridges.« less

Profiles of musculoskeletal development in limbs of college Olympic weightlifters and wrestlers.

PubMed

Kanehisa, H; Fukunaga, T

1999-04-01

To investigate the event-related profiles of musculoskeletal development in weight-categorized athletes, we measured the cross-sectional areas (CSA) of bone and muscle in the forearm, upper arm, lower leg and thigh, using a B-mode ultrasound apparatus, in college Olympic weightlifters (OWL, n = 19) and wrestlers (WR, n = 17) and untrained men (UM, n = 24), whose body masses were within the range from 55 kg to 78 kg. Both bone and muscle CSA at all sites were significantly correlated to the two-thirds power of fat-free mass (FFM(2/3)) with correlation coefficients of 0.430-40.741 (P < 0.05) and 0.608-0.718 (P < 0.05), respectively. Moreover, there were significant correlations between bone and muscle CSA at all sites (r = 0.664-0.829, P < 0.05). Even when bone and muscle CSA were expressed relative value to FFM(2/3), both OWL and WR showed significantly greater values than UM at all sites except for the lower leg. Furthermore, the comparison of the lean (bone + muscle) CSA ratio from site to site indicated a higher distribution of lean tissues in the upper extremities in OWL and WR compared to UM. While there was no significant difference between the two athlete groups in FFM(2/3), OWL showed significantly larger values than WR in the bone CSA of the upper arm and thigh and in the muscle CSA of the lower leg and thigh. However, lean CSA ratios of the upper extremities to the lower ones were significantly higher in WR than in OWL. Thus, the present results indicated that, compared to UM, OWL and WR had a greater lean tissue CSA in limbs, especially in the upper extremities, even when the difference in FFM was normalized. Moreover, the relative distribution of lean tissues in limbs differed between the two weight-categorized athletes in spite of there being no difference in FFM, which may be attributable to their own training regimens and/or competition style.

How Wolf-Rayet winds are driven by starlight and spectral lines

NASA Astrophysics Data System (ADS)

Onifer, Andrew Joseph, III

Finding the cause of the enormous increase in the mass- loss rate of a Wolf-Rayet (W-R) star, as compared to its O star progenitor, has remained a challenge for many years. This thesis explores the hypothesis that line driving causes the large observed W-R mass-loss rates. Frequency redistribution can cause the photons to filter into gaps in the line spectrum, reducing the efficiency of line driving. Therefore, the role that frequency redistribution plays in lowering the predicted mass-loss rate is explored, both via simple two-domain idealizations of the line list and via a real W-R line list. A simple analytic theory, called the Statistical Sobolev Rosseland (SSR) theory, is developed that calculates the local efficiency of line driving in a completely redistributing wind. In the process a conceptual language is developed to explain the key issues in W-R wind line driving. The results are that with no redistribution, the reduction in radius, and corresponding increase in temperature, of an O star as it evolves into a W-R star causes roughly a six-fold increase in the mass-loss rate. However, with large amounts of redistribution, the efficiency of the wind drops greatly in the presence of spectral gaps. In the most extreme case of SSR, the mass- loss rate drops by a factor of up to an order of magnitude relative to the gray value. To avoid this it is necessary to fill the gaps in the spectrum, and the effect that ionization stratification has in filling the gaps globally over the wind is explored. It is found that with the current line list ionization changes can only fill the gaps sufficiently to cause about a factor of two increase over the SSR value. The conclusion is that in order for line driving to explain the mass-loss rates of W-R winds, more opacity needs to be discovered to fill the gaps, either locally, or globally over a realistic range of ionization strata.

Betwixt and between: workplace perspectives on work reintegration in the eldercare sector in Denmark.

PubMed

Ladekjær Larsen, Eva; Labriola, Merete; Vinther Nielsen, Claus; Schultz Petersen, Kirsten

2015-01-01

Contemporary return-to-work (RTW) policies in Denmark and other welfare nations recommend employees on long-term sick leave, due to physical or mental health problems, to RTW gradually. Factors that influence the process of work reintegration (WR) is well documented, however, co-workers experiences of this process are a rather new research topic. Moreover, in the context of the present research, no studies have so far explored the workplace as an arena for social interaction. The aim of this study was to explore co-workers' experiences of the reintegration process and how these experiences are related to social positions at the workplace. Ethnographic fieldwork was conducted at two nursing homes that were in a process WR after long-term sick leave. The data consist of field notes, policy documents, individual interviews, and focus group interviews. Data were organized by use of NVivo. A theoretical framework was adopted which enabled us to approach and interpret the reintegration process as one that changed the social position of the returning employee. The dataset demonstrates how the returnee is in a state of being betwixt and between the social positions of a co-worker and a non-co-worker. This is illustrated in three cases which show that this state prevents the returnee from taking on the role as a co-worker, excludes the returnee from the workplace, and creates uncertainty for all workplace actors. The study highlighted that WR creates a social position for the returnee that complicates the working routine and causes uncertainty in social interactions. Implications for Rehabilitation Work reintegration (WR) after long-term sick leave is commonly characterized by reduced working hours and modified working tasks. The WR process influences the whole work place including co-workers' everyday working life and complicates work situations where work tasks and roles are negotiated between the returning worker and co-workers. Future WR policies and guidelines could benefit from integrating co-workers' perspective to ensure that the returning worker is not socially excluded as well as ensuring that co-workers are not overburdened in the process.

Neutrino jets from high-mass WR gauge bosons in TeV-scale left-right symmetric models

NASA Astrophysics Data System (ADS)

Mitra, Manimala; Ruiz, Richard; Scott, Darren J.; Spannowsky, Michael

2016-11-01

We reexamine the discovery potential at hadron colliders of high-mass right-handed (RH) gauge bosons WR—an inherent ingredient of left-right symmetric models (LRSM). We focus on the regime where the WR is very heavy compared to the heavy Majorana neutrino N , and we investigate an alternative signature for WR→N decays. The produced neutrinos are highly boosted in this mass regime. Subsequently, their decays via off-shell WR bosons to jets, i.e., N →ℓ±jj, are highly collimated, forming a single neutrino jet (jN). The final-state collider signature is then ℓ±jN, instead of the widely studied ℓ±ℓ±j j . Present search strategies are not sensitive to this hierarchical mass regime due to the breakdown of the collider signature definition. We take into account QCD corrections beyond next-to-leading order (NLO) that are important for high-mass Drell-Yan processes at the 13 TeV Large Hadron Collider (LHC). For the first time, we evaluate WR production at NLO with threshold resummation at next-to-next-to-leading logarithm (NNLL) matched to the threshold-improved parton distributions. With these improvements, we find that a WR of mass MWR=3 (4 )[5 ] TeV and mass ratio of (mN/MWR)<0.1 can be discovered with a 5 - 6 σ statistical significance at 13 TeV after 10 (100 )[2000 ] fb-1 of data. Extending the analysis to the hypothetical 100 TeV Very Large Hadron Collider (VLHC), 5 σ can be obtained for WR masses up to MW R=15 (30 ) with approximately 100 fb-1 (10 ab-1 ). Conversely, with 0.9 (10 )[150 ] fb-1 of 13 TeV data, MWR<3 (4 )[5 ] TeV and (mN/MWR)<0.1 can be excluded at 95% C.L.; with 100 fb-1 (2.5 ab-1 ) of 100 TeV data, MW R<22 (33 ) TeV can be excluded.

Multiwavelength observations of NaSt1 (WR 122): equatorial mass loss and X-rays from an interacting Wolf-Rayet binary

NASA Astrophysics Data System (ADS)

Mauerhan, Jon; Smith, Nathan; Van Dyk, Schuyler D.; Morzinski, Katie M.; Close, Laird M.; Hinz, Philip M.; Males, Jared R.; Rodigas, Timothy J.

2015-07-01

NaSt1 (aka Wolf-Rayet 122) is a peculiar emission-line star embedded in an extended nebula of [N II] emission with a compact dusty core. The object was previously characterized as a Wolf-Rayet (WR) star cloaked in an opaque nebula of CNO-processed material, perhaps analogous to η Car and its Homunculus nebula, albeit with a hotter central source. To discern the morphology of the [N II] nebula we performed narrow-band imaging using the Hubble Space Telescope and Wide-field Camera 3. The images reveal that the nebula has a disc-like geometry tilted ≈12° from edge-on, composed of a bright central ellipsoid surrounded by a larger clumpy ring. Ground-based spectroscopy reveals radial velocity structure (±10 km s-1) near the outer portions of the nebula's major axis, which is likely to be the imprint of outflowing gas. Near-infrared adaptive-optics imaging with Magellan AO has resolved a compact ellipsoid of Ks-band emission aligned with the larger [N II] nebula, which we suspect is the result of scattered He I line emission (λ2.06 μm). Observations with the Chandra X-ray Observatory have revealed an X-ray point source at the core of the nebula that is heavily absorbed at energies <1 keV and has properties consistent with WR stars and colliding-wind binaries. We suggest that NaSt1 is a WR binary embedded in an equatorial outflow that formed as the result of non-conservative mass transfer. NaSt1 thus appears to be a rare and important example of a stripped-envelope WR forming through binary interaction, caught in the brief Roche lobe overflow phase.

Accessory cells in physiological lymphoid tissue from the intestine: an immunohistochemical study.

PubMed

Sarsfield, P; Rinne, A; Jones, D B; Johnson, P; Wright, D H

1996-03-01

We report a study of the organization of accessory cell populations, in normal mucosal lymphoid tissue from small intestine (8 cases), large intestine (6) and appendix (9) using a panel of monoclonal antibodies and polyclonal antisera in paraffin-embedded tissue. Two populations were identified in dome areas, one positive for acid cysteine proteinase inhibitor and HLA class II (WR18) only and the second positive for S-100 protein, CD68, and WR18 and negative for acid cysteine proteinase inhibitor and factor XIIIa. Superficial colonic mucosal and small intestinal villous tip macrophages stained positively with CD68 and WR18 only, while deeper cryptal and submucosal populations exhibited additional positivity for factor XIIIa, but both populations were negative for acid cysteine proteinase inhibitor and S-100 protein. Germinal centre macrophages were positive for CD68, WR18 and acid cysteine proteinase inhibitor and negative for factor XIIIa, and S-100 protein. T zone dendritic cells included a population which stained positively for S-100 protien, WR18 and were negative for factor XIIIa, CD68 and acid cysteine proteinase inhibitor, an immunophenotype typical of interdigitating dendritic reticulum cells. This distribution of phenotypically identifiable accessory cell subpopulations was apparent at all three sites examined. We suggest that the specialized subpopulations of dendritic cells staining for S-100 protein and for acid cysteine proteinase inhibitor which are restricted to the dome areas, may have a potential role in the transfer of antigen across the epithelium to the germinal centres, while factor XIIIa appears to identify a tissue macrophage population with a potential role in stromal modulation distant from direct antigen challenge.

Combined effect of coffee ingestion and repeated bouts of low-intensity exercise on fat oxidation.

PubMed

Kurobe, Kazumichi; Nakao, Saori; Nishiwaki, Masato; Matsumoto, Naoyuki

2017-03-01

We investigated the effect of the combination of coffee ingestion and repeated bouts of low-intensity exercise on fat oxidation. Subjects were seven young, healthy male adults. They performed four trials: a single 30-min bout of exercise following ingestion of plain hot water (WS) or coffee (CS); a trial with three 10-min bouts of exercise separated by 10-min periods of rest following ingestion of plain hot water (WR) or coffee (CR). The coffee contained 5 mg kg -1 of caffeine. All trials were performed on a cycle ergometer at 40% maximal oxygen uptake for each subject an hour after beverage ingestion. Oxygen uptake in the CS and CR trials was higher compared with the WS and WR trials at 90 min after exercise (P<0·05). Respiratory exchange ratio (RER) in the CS and CR trials was decreased during the whole recovery period compared with baseline (P<0·05), whereas no significant decreases were observed in either the WS or WR trials. Moreover, RER was significantly lower at 30 min after exercise in the CR trial than in either the WS or WR trials (P<0·05 each). Similarly, it is notable that fat oxidation rate in the CR trial was significantly higher at 30 min after exercise compared to that in the WS and WR trials (P<0·05). These results suggest that the combination of coffee intake and repeated bouts of low-intensity exercise enhances fat oxidation in the period after exercise. © 2015 Scandinavian Society of Clinical Physiology and Nuclear Medicine. Published by John Wiley & Sons Ltd.

Characterizing Wolf-Rayet stars in the near- and mid-infrared

DOE Office of Scientific and Technical Information (OSTI.GOV)

Faherty, Jacqueline K.; Shara, Michael M.; Zurek, David

We present refined color-color selection criteria for identifying Wolf-Rayet (WR) stars using available mid-infrared (MIR) photometry from WISE in combination with near-infrared (NIR) photometry from the Two Micron All Sky Survey. Using a sample of spectrally classified objects, we find that WR stars are well distinguished from the field stellar population in the (W1 – W2) versus (J – K{sub s} ) color-color diagram, and further distinguished from other emission line objects such as planetary nebulae, Be, and cataclysmic variable stars using a combination of NIR and MIR color constraints. As proof of concept we applied the color constraints tomore » a photometric sample in the Galactic plane, located WR star candidates, and present five new spectrally confirmed and classified WC (1) and WN (4) stars. Analysis of the 0.8-5.0 μm spectral data for a subset of known, bright WC and WN stars shows that emission lines (primarily He I) extend into the 3.0-5.0 μm spectral region, although their strength is greatly diminished compared to the 0.8-2.5 μm region. The WR population stands out relative to background field stars at NIR and MIR colors due to an excess continuum contribution, likely caused by free-free scattering in dense winds. Mean photometric properties of known WRs are presented and imply that reddened late-type WN and WC sources are easier to detect than earlier-type sources at larger Galactic radii. WISE W3 and W4 images of 10 WR stars show evidence of circumstellar shells linked to mass ejections from strong stellar winds.« less

Electrical anisotropy of gas hydrate-bearing sand reservoirs in the Gulf of Mexico

USGS Publications Warehouse

Cook, Anne E.; Anderson, Barbara I.; Rasmus, John; Sun, Keli; Li, Qiming; Collett, Timothy S.; Goldberg, David S.

2012-01-01

We present new results and interpretations of the electricalanisotropy and reservoir architecture in gashydrate-bearingsands using logging data collected during the Gulf of MexicoGasHydrate Joint Industry Project Leg II. We focus specifically on sandreservoirs in Hole Alaminos Canyon 21 A (AC21-A), Hole Green Canyon 955 H (GC955-H) and Hole Walker Ridge 313 H (WR313-H). Using a new logging-while-drilling directional resistivity tool and a one-dimensional inversion developed by Schlumberger, we resolve the resistivity of the current flowing parallel to the bedding, R| and the resistivity of the current flowing perpendicular to the bedding, R|. We find the sandreservoir in Hole AC21-A to be relatively isotropic, with R| and R| values close to 2 Ω m. In contrast, the gashydrate-bearingsandreservoirs in Holes GC955-H and WR313-H are highly anisotropic. In these reservoirs, R| is between 2 and 30 Ω m, and R| is generally an order of magnitude higher. Using Schlumberger's WebMI models, we were able to replicate multiple resistivity measurements and determine the formation resistivity the gashydrate-bearingsandreservoir in Hole WR313-H. The results showed that gashydrate saturations within a single reservoir unit are highly variable. For example, the sand units in Hole WR313-H contain thin layers (on the order of 10-100 cm) with varying gashydrate saturations between 15 and 95%. Our combined modeling results clearly indicate that the gashydrate-bearingsandreservoirs in Holes GC955-H and WR313-H are highly anisotropic due to varying saturations of gashydrate forming in thin layers within larger sand units.

Light absorbing material (soot) in rainwater and in aerosol particles in the Maldives

NASA Astrophysics Data System (ADS)

Granat, L.; EngströM, J. E.; Praveen, S.; Rodhe, H.

2010-08-01

Simultaneous measurements of soot (absorbing material at 528 nm) and inorganic ions in aerosol and precipitation at the Maldives Climate Observatory Hanimaadhoo during the period May 2005 to February 2007 have made it possible to calculate the washout ratio (WR) of these components as a measure of how efficiently they are scavenged by precipitation. On the basis of air trajectories the data have been separated into days with polluted air arriving from the Indian subcontinent in a northeasterly sector during winter and clean monsoon days with southerly flow from the Indian Ocean. The average soot concentration was a factor of 10 higher in the former situations. Despite considerable scatter for individual days, a systematic pattern emerged when the WR for the different components were compared with each other. During the monsoon season the WR for soot was similar to that of sulfate and other fine mode aerosol components, indicating that soot containing particles in these situations were efficient as cloud condensation nuclei. The origin of the light absorbing material during the monsoon season is unclear. During the polluted winter days, on the other hand, the WR for soot was three times smaller than that of sulfate. This indicates that, even after a travel time of several days, the soot containing particles from India have retained much of their hydrophobic property. The low WR and the infrequent rain during this season probably contribute to extending the atmospheric lifetime of soot well beyond several days. Surprisingly high concentrations of non-sea-salt calcium were measured during the monsoon season, substantially higher than during the winter season. The origin of these high values could be long-range transport from the Australian or African continents. Another possibility might be exopolymer gels derived from the ocean surface microlayer.

Quantitative Estimation of the Impact of European Teleconnections on Interannual Variation of East Asian Winter Temperature and Monsoon

NASA Technical Reports Server (NTRS)

Lim, Young-Kwon; Kim, Hae-Dong

2014-01-01

The impact of European teleconnections including the East AtlanticWest Russia (EA-WR), the Scandinavia (SCA), and the East Atlantic (EA) on East Asian winter temperature variability was quantified and compared with the combined effect of the Arctic Oscillation (AO), the Western Pacific (WP), and the El-Nino Southern Oscillation (ENSO), which are originated in the Northern Hemispheric high-latitudes or the Pacific. Three European teleconnections explained 22-25 percent of the total monthly upper-tropospheric height variance over Eurasia. Regression analysis revealed warming by EA-WR and EA and cooling by SCA over mid-latitude East Asia during their positive phase and vice versa. Temperature anomalies were largely explained by the advective temperature change process at the lower troposphere. The average spatial correlation over East Asia (90-180E, 10-80N) for the last 34 winters between observed and reconstructed temperature comprised of AO, WP and ENSO effect (AWE) was approximately 0.55, and adding the European teleconnection components (ESE) to the reconstructed temperature improved the correlation up to approximately 0.64. Lower level atmospheric structure demonstrated that approximately five of the last 34 winters were significantly better explained by ESE than AWE to determine East Asian seasonal winter temperatures. We also compared the impact between EA-WR and AO on the 1) East Asian winter monsoon, 2) cold surge, and 3) the Siberian high. These three were strongly coupled, and their spatial features and interannual variation were somewhat better explained by EA-WR than AO. Results suggest that the EA-WR impact must be treated more importantly than previously thought for a better understanding of East Asian winter temperature and monsoon variability.

Reply to Comment by Roques et al. on "Base Flow Recession from Unsaturated-Saturated Porous Media considering Lateral Unsaturated Discharge and Aquifer Compressibility"

NASA Astrophysics Data System (ADS)

Liang, Xiuyu; Zhan, Hongbin; Zhang, You-Kuan; Schilling, Keith

2018-04-01

Roques et al. (https://doi.org/10.1002/2017WR022085) claims that they have proposed an exponential time step (ETS) method to improve the computing method of Liang et al. (https://doi.org/10.1002/2017WR020938) which used a constant time step (CTS) method on the derivative for dQ/dt in field data, where Q is the base flow discharge and t is the time since the start of base flow recession. This reply emphasizes that the main objective of Liang et al. (https://doi.org/10.1002/2017WR020938) was to develop an analytical model to investigate the effects of the unsaturated flow on base flow recession, not on the data interpretation methods. The analytical model indicates that the base flow recession hydrograph behaves as dQ/dt ˜aQb with the exponent b close to 1 at late times, which is consistent with previous theoretical models. The model of Liang et al. (https://doi.org/10.1002/2017WR020938) was applied to field data where the derivative of dQ/dt was computed using the CTS method, a method that has been widely adopted in previous studies. The ETS method proposed by Roques et al. (https://doi.org/10.1016/j.advwatres.2017.07.013) appears to be a good alternative but its accuracy needs further validation. Using slopes to fit field data as proposed by Roques et al. (https://doi.org/10.1002/2017WR022085) appears to match data satisfactorily at early times whereas it performs less satisfactorily at late times and leads to the exponent b being obviously larger than 1.

The significance of 123I-BMIPP delayed scintigraphic imaging in cardiac patients.

PubMed

Akashi, Yoshihiro J; Kida, Keisuke; Suzuki, Kae; Inoue, Koji; Kawasaki, Kensuke; Yamauchi, Masahiro; Musha, Haruki; Anker, Stefan D

2007-04-25

Earlier studies have not fully investigated the significance of radionuclide planar imaging in cardiac patients using the fatty acid analogue 123I-beta-methyl-iodophenylpentadecanoic acid (123I-BMIPP). This study was to clarify the effectiveness of 123I-BMIPP in assessing the heart-to-mediastinum ratio (H/M) and myocardial washout rate (WR) in patients with heart disease. Myocardial 123I-BMIPP imaging was performed in 33 patients (20 with chronic heart failure [CHF] and 13 with stable angina pectoris [AP]) and 11 control subjects. Myocardial 123I-BMIPP planner images were obtained 30 min (early image) and 4 h (delayed image) after tracer injection. The left ventricular ejection fraction (LVEF) was measured by quantitative gated single photon emission computed tomography. The concentration of plasma brain natriuretic peptide (BNP) was measured before the scintigraphic study. (1) Delayed H/M was much lower in CHF than in AP (1.93 +/- 0.37 vs. 2.21 +/- 0.38, p < 0.05) and controls (vs. 2.47 +/- 0.38, p < 0.001). (2) The WR in CHF and AP were higher than the WR in controls (39.8 +/- 12.7% and 38.7 +/- 11.1 vs. 27.9 +/- 10.2%, p < 0.01 and p < 0.05, respectively). (3) In all subjects, LVEF was correlated with delayed H/M (r = 0.39, p < 0.01). And, the BNP was correlated with both the WR (r = 0.36, p < 0.05) and delayed H/M (r = - 0.29, p = 0.05). These data strongly suggest that the delayed H/M and myocardial WR of 123I-BMIPP enhances the assessment of the myocardial fatty acid metabolism disorders in patients with heart disease in both masked and unmasked conditions.

Propierties of dust in circumstellar gas around Wolf-Rayet stars

NASA Astrophysics Data System (ADS)

Jiménez-Hernández, P.; Arthur, S. J.; Toalá, J. A.

2017-11-01

Using archive photometric observations from Herschel (70μm, 100μm, 160μm and 250μm), Spitzer (24μm) and WISE (22μm and 12μm) we obtained infrared SED's of nebulae around the Wolf-Rayet stars WR 124, WR 16 and WR 7. We used the photoionization code Cloudy to construct models of the nebulae, taking into account the spectrum of the central star and varying the density and distance of the photoionized shell as well as the size distribution and chemical composition of the dust grains mixed with the gas, and we compared the resulting SEDs with the observations in order to study the properties of the dust in these objects. We discuss whether the dust properties depend on the spectral type of the central star and the age of the nebulae.

[Radiation Anticarcinogenesis by Thiazolidine Pro-drug

NASA Technical Reports Server (NTRS)

Warters, Raymond L.; Roberts, Jeanette C.; Fain, Heidi

1999-01-01

The original goal of this work was to determine the capacity of selected aminothiols to modulate radiation induced cytotoxicity, mutagenesis and carcinogenesis in a human mammary epithelial cell line. The conclusions from this work are that WR-1065 is the "gold standard" for protection against radiation induced cytotoxicity, mutagenesis and carcinogenesis. While a potent radiation protector, WR-1065 is cytotoxic in vitro and in vivo. Our rationale for a study of the thiazolidine pro-drugs was that these compounds are neither toxic in vitro or in vivo. The results obtained during this funding period indicate that the thiazolidine pro-drugs are as potent as WR-1065 as protectors against radiation induced mutation induction, and thus presumably against radiation induced carcinogenesis. Our results indicate that the thiazolidine prodrugs are excellent candidates to test as non-toxic anticarcinogens for protecting astronauts from cancer induction during space travel.

Blood schizontocidal activity of WR 238605 (Tafenoquine) against Plasmodium cynomolgi and Plasmodium fragile infections in rhesus monkeys.

PubMed

Puri, S K; Dutta, G P

2003-04-01

A new 8-aminoquinoline antimalarial WR 238605 (Tafenoquine), developed initially as a primaquine alternative for prevention of Plasmodium vivax relapses was evaluated for blood schizontocidal activity against two simian malaria infections namely Plasmodium cynomolgi B and Plasmodium fragile in rhesus monkeys. Treatment with WR 238605 at a dose of 3.16 mg(base)/kg/day x 7 days cured established trophozoite induced infections in monkeys with both these parasites. The lower dose of 1.00 mg/kg/day cured 9 out of 12 monkeys infected with P. cynomolgi B and 10 out of 11 monkeys infected with P. fragile. Primaquine was only partially curative at 10.0 mg(base)/kg/day x 7 dose regimen against both these infections. The potent blood schizontocidal activity of tafenoquine adds to the armoury of antimalarial drugs.

Etude de la variabilite des etoiles massives a l'aide de la photometrie et la spectroscopie

NASA Astrophysics Data System (ADS)

Lefevre, Laure

Les étoiles Wolf-Rayet (WR) de population I sont les descendants évolués des étoiles massives de type O. Elles présentent de larges raies en émission produites par des atomes ionisés qui forment le vent stellaire chaud, den se et rapide. Il y a deux classes principales d'étoiles WR: les WN, ou les raies de l'azote dominent, et les WC (WO) ou les raies du carbone (de l'oxygène) dominent. Des observations récentes ont révelé que les vents sont "fragmentés" à petite et grande échelle, ce qui pourrait être relié en partie à des petites surdensités situées dans le vent en expansion. Cette thèse de doctorat présente la détection, l'analyse et l'interprétation, avec des outils statistiques avancés, de la variabilité dans les courbes de lumière, les vitesses radiales, et les spectres de deux étoiles WR caractéristiques (WR137 et WR123) et dans les étoiles OB observées par le satellite HIPPARCOS. Une campagne de spectroscopie intensive a été réalisée en 1999-2000 pour améliorer notre connaissance des composantes orbitales de WR137 (WC7pd+O9) et étudier les vents des WR et les conditions de formation des poussières dans de tels milieux. Le premier volet de cette thèse a permis de déduire de ces observations une orbite spectroscopique d'environ 13 ans qui confirme et précise les précédents résultats. Grace à l'analyse des spectres de cette campagne, ce travail a mis à jour une deuxième période d'oscillation de très faible amplitude de 0.83 j dans les spectres de WR137. Celle-ci pourrait être reliée aux pulsations ou à de grandes structures qui tourneraient dans le vent comme dans l'étoile EZ CMa (WR6). Une analyse en ondelettes a également permis d'isoler et de suivre pendant plusieurs heures des structures en haut des raies de CIII et CIV dans le spectre de WR137. De plus, la corrélation croisée a permis de voir que les raies formées à différentes distances de l'étoile sont probablement reliées entre elles. Enfin l'analyse des surdentsités a permis de déduire un [beta] ~ 5 nettement supérieur à la valeur de [beta] [Asymptotically to] 1 que l'on trouve dans le vent des étoiles O ( loi -[beta] de vitesse dans le vent) . Le second volet de cette thèse concerne les étoiles WN, et plus particulièrement une WN8 du nom de WR123. Les WN8 se distinguent de leur congénères WR par plusieurs caractéristiques, dont le niveau de variabilité le plus élevé de leur classe. Du fait de ces particularités, les étoiles WN8, WR123 parmi elles, ont fait l'objet de nombreuses études photométriques et spectroscopiques. Cependant l'extrême complexité des variations, combinée avec une couverture temporelle souvent inadaptée a conduit à une longue série de résultats ambigus. Avec les données exceptionnelles collectées par le premier satellite astronomique canadien MOST, ce mémoire de thèse est maintenant en mesure de répondre a une grande partie des interrogations posées. L'étoile WR123 a été observée avec MOST en mode direct toutes les 30s pendant 38 jours en juin-juillet 2004. L'analyse de Fourier montre qu'aucun signal n'est stable pour plus de quelques jours dans le domaine des basses fréquences et qu'a ucune variabilité significative n'est présente dans le domaine des hautes fréquences jusqu'à un niveau de 0.2 mmag, un ordre de magnitude plus bas que les prédictions pour les pulsations à modes étranges. Par contre, i1 semble y avoir une période de 9.8 heures présente pendant toute la durée des observations. Cette période, probablement reliée à des pulsations, pourrait permettre de mieux comprendre ce qui se passe dans les étoiles WR et leurs vents. Le troisième volet de cette thèse consiste en une analyse des différents types de variabilité des étoiles OB du catalogue HIPPARCOS. Un échantillon non biaisé de 2497 étoiles a donc été sélectionné et analysé. Il apparait que le seuil de variabilité à 99.9% établi par le consortium HIPPARCOS n'est pas représentatif de cet échantillon. Il a donc été recalculé et les étoiles (classées dans 4 catégories principales de variabilité intrinsèque ou extrinsèque) "variables" ont été réanalysées lors de cette thèse. Ce travail a permis de confirmer des résultats obtenus à partir d'échantillons trop restreints sur les super-géantes OB, de confirmer que les étoiles OBe sont très variables ([approximate] 80%) et de soulever plusieurs questions intéressantes sur les étoiles OB de la séquence principale qui sont moins variables en moyenne. On note également plus de systèmes en contact que détachés parmi les OBMS et OBe et un nombre ~ identique parmi les OBSC.

27 CFR 9.179 - Southern Oregon.

Code of Federal Regulations, 2011 CFR

2011-04-01

... township line T22S-T23S; then (4) Proceed southeast approximately 8.5 miles along a straight line to the intersection of township line T23S-T24S with range line R7W-R8W; then south along the R7W-R8W range line... a straight line approximately 3.5 miles toward the intersection of township line T25S-T26S with...

27 CFR 9.179 - Southern Oregon.

Code of Federal Regulations, 2010 CFR

2010-04-01

... township line T22S-T23S; then (4) Proceed southeast approximately 8.5 miles along a straight line to the intersection of township line T23S-T24S with range line R7W-R8W; then south along the R7W-R8W range line... a straight line approximately 3.5 miles toward the intersection of township line T25S-T26S with...

Genetic bases of fungal white rot wood decay predicted by phylogenomic analysis of correlated gene-phenotype evolution

Treesearch

László G. Nagy; Robert Riley; Philip J. Bergmann; Krisztina Krizsán; Francis M. Martin; Igor V. Grigoriev; Dan Cullen; David S. Hibbett

2016-01-01

Fungal decomposition of plant cell walls (PCW) is a complex process that has diverse industrial applications and huge impacts on the carbon cycle. White rot (WR) is a powerful mode of PCW decay in which lignin and carbohydrates are both degraded. Mechanistic studies of decay coupled with comparative genomic analyses have provided clues to the enzymatic components of WR...

Fabrication of WS2/GaN p-n Junction by Wafer-Scale WS2 Thin Film Transfer

PubMed Central

Yu, Yang; Fong, Patrick W. K.; Wang, Shifeng; Surya, Charles

2016-01-01

High quality wafer-scale free-standing WS2 grown by van der Waals rheotaxy (vdWR) using Ni as a texture promoting layer is reported. The microstructure of vdWR grown WS2 was significantly modified from mixture of crystallites with their c-axes both parallel to (type I) and perpendicular to (type II) the substrate to large type II crystallites. Wafer-scale transfer of vdWR grown WS2 onto different substrates by an etching-free technique was demonstrated for the first time that utilized the hydrophobic property of WS2 and hydrophilic property of sapphire. Our results show that vdWR is a reliable technique to obtain type-II textured crystallites in WS2, which is the key factor for the wafer-scale etching-free transfer. The transferred films were found to be free of observable wrinkles, cracks, or polymer residues. High quality p-n junctions fabricated by room-temperature transfer of the p-type WS2 onto an n-type GaN was demonstrated with a small leakage current density of 29.6 μA/cm2 at −1 V which shows superior performances compared to the directly grown WS2/GaN heterojunctions. PMID:27897210

Accurate Region-of-Interest Recovery Improves the Measurement of the Cell Migration Rate in the In Vitro Wound Healing Assay.

PubMed

Bedoya, Cesar; Cardona, Andrés; Galeano, July; Cortés-Mancera, Fabián; Sandoz, Patrick; Zarzycki, Artur

2017-12-01

The wound healing assay is widely used for the quantitative analysis of highly regulated cellular events. In this essay, a wound is voluntarily produced on a confluent cell monolayer, and then the rate of wound reduction (WR) is characterized by processing images of the same regions of interest (ROIs) recorded at different time intervals. In this method, sharp-image ROI recovery is indispensable to compensate for displacements of the cell cultures due either to the exploration of multiple sites of the same culture or to transfers from the microscope stage to a cell incubator. ROI recovery is usually done manually and, despite a low-magnification microscope objective is generally used (10x), repositioning imperfections constitute a major source of errors detrimental to the WR measurement accuracy. We address this ROI recovery issue by using pseudoperiodic patterns fixed onto the cell culture dishes, allowing the easy localization of ROIs and the accurate quantification of positioning errors. The method is applied to a tumor-derived cell line, and the WR rates are measured by means of two different image processing software. Sharp ROI recovery based on the proposed method is found to improve significantly the accuracy of the WR measurement and the positioning under the microscope.

Voluntary resistance running induces increased hippocampal neurogenesis in rats comparable to load-free running.

PubMed

Lee, Min Chul; Inoue, Koshiro; Okamoto, Masahiro; Liu, Yu Fan; Matsui, Takashi; Yook, Jang Soo; Soya, Hideaki

2013-03-14

Recently, we reported that voluntary resistance wheel running with a resistance of 30% of body weight (RWR), which produces shorter distances but higher work levels, enhances spatial memory associated with hippocampal brain-derived neurotrophic factor (BDNF) signaling compared to wheel running without a load (WR) [17]. We thus hypothesized that RWR promotes adult hippocampal neurogenesis (AHN) as a neuronal substrate underlying this memory improvement. Here we used 10-week-old male Wistar rats divided randomly into sedentary (Sed), WR, and RWR groups. All rats were injected intraperitoneally with the thymidine analogue 5-Bromo-2'-deoxuridine (BrdU) for 3 consecutive days before wheel running. We found that even when the average running distance decreased by about half, the average work levels significantly increased in the RWR group, which caused muscular adaptation (oxidative capacity) for fast-twitch plantaris muscle without causing any negative stress effects. Additionally, immunohistochemistry revealed that the total BrdU-positive cells and newborn mature cells (BrdU/NeuN double-positive) in the dentate gyrus increased in both the WR and RWR groups. These results provide new evidence that RWR has beneficial effects on AHN comparable to WR, even with short running distances. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

Weighting factors for radiation quality: how to unite the two current concepts.

PubMed

Kellerer, Albrecht M

2004-01-01

The quality factor, Q(L), used to be the universal weighting factor to account for radiation quality, until--in its 1991 Recommendations--the ICRP established a dichotomy between 'computable' and 'measurable' quantities. The new concept of the radiation weighting factor, w(R), was introduced for use with the 'computable' quantities, such as the effective dose, E. At the same time, the application of Q(L) was restricted to 'measurable' quantities, such as the operational quantities ambient dose equivalent or personal dose equivalent. The result has been a dual system of incoherent dosimetric quantities. The most conspicuous inconsistency resulted for neutrons, for which the new concept of wR had been primarily designed. While its definition requires an accounting for the gamma rays produced by neutron capture in the human body, this effect is not adequately reflected in the numerical values of wR, which are now suitable for mice, but are--at energies of the incident neutrons below 1 MeV--conspicuously too large for man. A recent Report 92 to ICRP has developed a proposal to correct the current imbalance and to define a linkage between the concepts Q(L) and wR. The proposal is here considered within a broader assessment of the rationale that led to the current dual system of dosimetric quantities.

Attention networks in adolescent anorexia nervosa.

PubMed

Weinbach, Noam; Sher, Helene; Lock, James D; Henik, Avishai

2018-03-01

Anorexia nervosa (AN) usually develops during adolescence when considerable structural and functional brain changes are taking place. Neurocognitive inefficiencies have been consistently found in adults with enduring AN and were suggested to play a role in maintaining the disorder. However, such findings are inconsistent in children and adolescents with AN. The current study conducted a comprehensive assessment of attention networks in adolescents with AN who were not severely underweight during the study using an approach that permits disentangling independent components of attention. Twenty partially weight-restored adolescents with AN (AN-WR) and 24 healthy adolescents performed the Attention Network Test which assesses the efficiency of three main attention networks-executive control, orienting, and alerting. The results revealed abnormal function in the executive control network among adolescents with AN-WR. Specifically, adolescents with AN-WR demonstrated superior ability to suppress attention to task-irrelevant information while focusing on a central task. Moreover, the alerting network modulated this ability. No difference was found between the groups in the speed of orienting attention, but reorienting attention to a target resulted in higher error rates in the AN-WR group. The findings suggest that adolescents with AN have attentional abnormalities that cannot be explained by a state of starvation. These attentional dysregulations may underlie clinical phenotypes of the disorder such as increased attention of details.

Fabrication of WS2/GaN p-n Junction by Wafer-Scale WS2 Thin Film Transfer.

PubMed

Yu, Yang; Fong, Patrick W K; Wang, Shifeng; Surya, Charles

2016-11-29

High quality wafer-scale free-standing WS 2 grown by van der Waals rheotaxy (vdWR) using Ni as a texture promoting layer is reported. The microstructure of vdWR grown WS 2 was significantly modified from mixture of crystallites with their c-axes both parallel to (type I) and perpendicular to (type II) the substrate to large type II crystallites. Wafer-scale transfer of vdWR grown WS 2 onto different substrates by an etching-free technique was demonstrated for the first time that utilized the hydrophobic property of WS 2 and hydrophilic property of sapphire. Our results show that vdWR is a reliable technique to obtain type-II textured crystallites in WS 2 , which is the key factor for the wafer-scale etching-free transfer. The transferred films were found to be free of observable wrinkles, cracks, or polymer residues. High quality p-n junctions fabricated by room-temperature transfer of the p-type WS 2 onto an n-type GaN was demonstrated with a small leakage current density of 29.6 μA/cm 2 at -1 V which shows superior performances compared to the directly grown WS 2 /GaN heterojunctions.

Study of T-wave morphology parameters based on Principal Components Analysis during acute myocardial ischemia

NASA Astrophysics Data System (ADS)

Baglivo, Fabricio Hugo; Arini, Pedro David

2011-12-01

Electrocardiographic repolarization abnormalities can be detected by Principal Components Analysis of the T-wave. In this work we studied the efect of signal averaging on the mean value and reproducibility of the ratio of the 2nd to the 1st eigenvalue of T-wave (T21W) and the absolute and relative T-wave residuum (TrelWR and TabsWR) in the ECG during ischemia induced by Percutaneous Coronary Intervention. Also, the intra-subject and inter-subject variability of T-wave parameters have been analyzed. Results showed that TrelWR and TabsWR evaluated from the average of 10 complexes had lower values and higher reproducibility than those obtained from 1 complex. On the other hand T21W calculated from 10 complexes did not show statistical diferences versus the T21W calculated on single beats. The results of this study corroborate that, with a signal averaging technique, the 2nd and the 1st eigenvalue are not afected by noise while the 4th to 8th eigenvalues are so much afected by this, suggesting the use of the signal averaged technique before calculation of absolute and relative T-wave residuum. Finally, we have shown that T-wave morphology parameters present high intra-subject stability.

Novel Formulation Strategy to Improve the Feasibility of Amifostine Administration.

PubMed

Ranganathan, Kavitha; Simon, Eric; Lynn, Jeremy; Snider, Alicia; Zhang, Yu; Nelson, Noah; Donneys, Alexis; Rodriguez, Jose; Buchman, Lauren; Reyna, Dawn; Lipka, Elke; Buchman, Steven R

2018-03-19

Amifostine (AMF), a radioprotectant, is FDA-approved for intravenous administration in cancer patients receiving radiation therapy (XRT). Unfortunately, it remains clinically underutilized due to adverse side effects. The purpose of this study is to define the pharmacokinetic profile of an oral AMF formulation potentially capable of reducing side effects and increasing clinical feasibility. Calvarial osteoblasts were radiated under three conditions: no drug, AMF, and WR-1065 (active metabolite). Osteogenic potential of cells was measured using alkaline phosphatase staining. Next, rats were given AMF intravenously or directly into the jejunum, and pharmacokinetic profiles were evaluated. Finally, rats were given AMF orally or subcutaneously, and blood samples were analyzed for pharmacokinetics. WR-1065 preserved osteogenic potential of calvarial osteoblasts after XRT to a greater degree than AMF. Direct jejunal AMF administration incurred a systemic bioavailability of 61.5%. Subcutaneously administrated AMF yielded higher systemic levels, a more rapid peak exposure (0.438 vs. 0.875 h), and greater total systemic exposure of WR-1065 (116,756 vs. 16,874 ng*hr/ml) compared to orally administered AMF. Orally administered AMF achieves a similar systemic bioavailability and decreased peak plasma level of WR-1065 compared to intravenously administered AMF, suggesting oral AMF formulations maintain radioprotective efficacy without causing onerous side effects, and are clinically feasible.

Organic carbon, water repellency and soil stability to slaking at aggregate and intra-aggregate scales

NASA Astrophysics Data System (ADS)

Jordán López, Antonio; García-Moreno, Jorge; Gordillo-Rivero, Ángel J.; Zavala, Lorena M.; Cerdà, Artemi; Alanís, Nancy; Jiménez-Compán, Elizabeth

2015-04-01

Water repellency (WR) is a property of some soils that inhibits or delays water infiltration between a few seconds and days or weeks. Inhibited or delayed infiltration contributes to ponding and increases runoff flow generation, often increasing soil erosion risk. In water-repellent soils, water infiltrates preferentially through cracks or macropores, causing irregular soil wetting patterns, the development of preferential flow paths and accelerated leaching of nutrients. Although low inputs of hydrophobic organic substances and high mineralization rates lead to low degrees of WR in cropped soils, it has been reported that conservative agricultural practices may induce soil WR. Although there are many studies at catchment, slope or plot scales very few studies have been carried out at particle or aggregate scale. Intra-aggregate heterogeneity of physical, biological and chemical properties conditions the transport of substances, microbial activity and biochemical processes, including changes in the amount, distribution and chemical properties of organic matter. Some authors have reported positive relationships between soil WR and aggregate stability, since it may delay the entry of water into aggregates, increase structural stability and contribute to reduce soil erosion risk. Organic C (OC) content, aggregate stability and WR are therefore strongly related parameters. In the case of agricultural soils, where both the type of management as crops can influence all these parameters, it is important to evaluate the interactions among them and their consequences. Studies focused on the intra-aggregate distribution of OC and WR are necessary to shed light on the soil processes at a detailed scale. It is extremely important to understand how the spatial distribution of OC in soil aggregates can protect against rapid water entry and help stabilize larger structural units or lead to preferential flow. The objectives of this research are to study [i] the OC content and the intensity of WR in aggregates of different sizes. [ii] the intra-aggregate distribution of OC and the intensity of WR and [iii] the structural stability of soil aggregates relative to the OC content and the intensity of WR in soils under different crops (apricot, citrus and wheat) and different treatments (conventional tilling and mulching). Soil samples were collected from an experimental area (Luvic Calcisols and Calcic Luvisols) in the province of Sevilla (Southern Spain) under different crops (apricot, citrus and wheat) and different management types (conventional tillage with moldboard plow) and mulching (no-tilling and addition of wheat residues at rates varying between 5 and 8 Mg/ha/year). At each sampling site, soil blocks (50 cm long × 50 cm wide × 10 cm deep) were carefully collected to avoid disturbance of aggregates as much as possible and transported to the laboratory. At field moist condition, undisturbed soil aggregates were separated by hand. In order to avoid possible interferences due to disturbance by handling, aggregates broken during this process were discarded. Individual aggregates were arranged in paper trays and air-dried during 7 days under laboratory standard conditions. After air-drying, part of each sample was carefully divided for different analyses: [i] part of the original samples was sieved (2 mm) to eliminate coarse soil particles and homogenized for characterization of OC and N contents, C/N ratio and texture; [ii] part of the aggregates were dry-sieved (0.25-0.5, 0.5-1 and 1-2 mm) or measured with a caliper (2-5, 5-10 and 10-15 mm) and separated in different sieve-size classes for determination of WR and OC content; [iii] aggregates 10-15 mm in size were selected for obtaining aggregate layers using a soil aggregate erosion (SAE) apparatus and WR and OC content were determined at each layer; finally, [iv] in order to study the relation between stability to slaking, WR and OC, these properties were determined in 90 air-dried aggregates (about 10 mm in size) selected per treatment (mulched or conventional tillage) and crop (apricot, citrus and wheat). In this case, every set of aggregates was randomly divided in three groups (n = 30) for assessing stability to slaking, WR and OC, respectively. OC content in the fine earth fraction of soils under different crops did not show important variations, although it increased significantly from conventionally tilled to mulched soils. The distribution of OC content in aggregates with different size varied among soils under different crops, generally increasing with decreasing size. At the intra-aggregate level, OC concentrated preferably in the exterior layer of differently sized aggregates and of aggregate coatings and interior from conventionally tilled soils, probably because of recent organic inputs or leachates. In the case of mulched soils, higher concentrations were observed, but no significant differences among aggregate regions were found. The intensity of water repellency, determined by the ethanol method, did not show great variations among differently sized aggregates under different crops in the 0-10 cm layer, but increased significantly from conventionally tilled to mulched soils. Coarser aggregates were generally wettable, while finer aggregates showed slight water repellency. Regardless of variations in the distribution of OC in different layers of aggregate from conventionally tilled soils, great or significant differences in the distribution of water repellency at the intra-aggregate level were not found. In case of mulched soils such differences were not significant. Finally, the intensity of water repellency was much more important than the concentration of OC in the stability to slaking of aggregates.

Space dosimetry with the application of a 3D silicon detector telescope: response function and inverse algorithm.

PubMed

Pázmándi, Tamás; Deme, Sándor; Láng, Edit

2006-01-01

One of the many risks of long-duration space flights is the excessive exposure to cosmic radiation, which has great importance particularly during solar flares and higher sun activity. Monitoring of the cosmic radiation on board space vehicles is carried out on the basis of wide international co-operation. Since space radiation consists mainly of charged heavy particles (protons, alpha and heavier particles), the equivalent dose differs significantly from the absorbed dose. A radiation weighting factor (w(R)) is used to convert absorbed dose (Gy) to equivalent dose (Sv). w(R) is a function of the linear energy transfer of the radiation. Recently used equipment is suitable for measuring certain radiation field parameters changing in space and over time, so a combination of different measurements and calculations is required to characterise the radiation field in terms of dose equivalent. The objectives of this project are to develop and manufacture a three-axis silicon detector telescope, called Tritel, and to develop software for data evaluation of the measured energy deposition spectra. The device will be able to determine absorbed dose and dose equivalent of the space radiation.

Depletion of intracellular GSH and NPSH by buthionine sulfoximine and diethyl maleate: factors that influence enhancement of aerobic radiation response

DOE Office of Scientific and Technical Information (OSTI.GOV)

Varnes, M.E.; Biaglow, J.E.; Roizin-Towle, L.

1984-08-01

Many investigators have observed aerobic sensitization of V79, CHO and A549 (human lung carcinoma) cells upon depletion of GSH using buthionine sulfoximine (BSO). Recently the authors discovered that this aerobic sensitization can be reversed if WR-2721 or N-acetylcysteine is added to the cells just prior to irradiation. Reversal requires that the exogenous thiols be present during the time of irradiation. One possible explanation was that these thiols entered the cells and either increased the pool of cellular nonprotein thiols or reversed the thiol-depleted state by stimulation of GSH synthesis. Cells treated with BSO do not readily regenerate intracellular GSH becausemore » this agent irreversibly inhibits ..gamma..-glutamyl synthetase. They found that addition of WR-2721 or N-acetylcysteine to BSO-treated cells did not affect the rate of regeneration of intracellular GSH. Thus, reversal of the aerobic sensitization of A549 cells by BSO cannot be explained on the basis of intracellular thiol levels alone, or by rapid reversal of BSO inhibition. In addition, diethylmaleate (DEM)-treated cells are considerably different from BSO-treated cells with respect to the ability to regenerate GSH.« less

Detectability of Wolf-Rayet stars in M33 and Beyond the Local Group

NASA Astrophysics Data System (ADS)

Brocklebank, Aaron J.; Pledger, J. L.; Sansom, A. E.

2017-11-01

To understand how complete our surveys of Wolf-Rayet (WR) stars can be with the current generation of telescopes, we study images of M33, a galaxy with a nearly complete WR catalogue, and degrade them to investigate the detectability of WRs out to 30Mpc. We lose almost half of our sample at 4.2Mpc, and at 30Mpc we detect only those WRs in bright regions.

Final Environmental Assessment: C-17 Program Changes Altus Air Force Base, Oklahoma

DTIC Science & Technology

2004-07-01

speed aircraft on MTRs showed that there is little probability of structural damage from such operations ( Sutherland 1989). One finding in that...October. Plotkin, K.J., 1996. PCBoom3 Sonic Boom Prediction Model: Version 1.0c. Wyle Research Report WR 95-22C. May. Plotkin, K.J., Sutherland ...Rate on Aircraft Noise Annoyance. Volume 3: Hybrid Own-Home Experiment. Wyle Laboratories Research Report WR 93-22. December. Sutherland , L

Understanding the Institutional Dimension of Inter-Agency Collaboration: The Basic Model

DTIC Science & Technology

2012-10-01

period (2009- 2012]. Dacin, M.T., Goodstein, J. and W. R. Scott, “ Institutional Theory and Institutional Change” Introduction to the Special...Zucher, “The Institutionalization of Institutional Theory ”, in S. Clegg, C. Hardy and W.R. Nord (eds) Handbook of Organizational Studies, (1996...and open systems (5th ed.) Upper Saddle River, NJ: Prentice-Hall, p. 270. Scott, W.R., “Approaching adulthood: the maturing of institutional

PROBING WOLF–RAYET WINDS: CHANDRA/HETG X-RAY SPECTRA OF WR 6

DOE Office of Scientific and Technical Information (OSTI.GOV)

Huenemoerder, David P.; Schulz, N. S.; Gayley, K. G.

With a deep Chandra/HETGS exposure of WR 6, we have resolved emission lines whose profiles show that the X-rays originate from a uniformly expanding spherical wind of high X-ray-continuum optical depth. The presence of strong helium-like forbidden lines places the source of X-ray emission at tens to hundreds of stellar radii from the photosphere. Variability was present in X-rays and simultaneous optical photometry, but neither were correlated with the known period of the system or with each other. An enhanced abundance of sodium revealed nuclear-processed material, a quantity related to the evolutionary state of the star. The characterization of themore » extent and nature of the hot plasma in WR 6 will help to pave the way to a more fundamental theoretical understanding of the winds and evolution of massive stars.« less

Discovery of a Wolf-Rayet Star through Detection of Its Photometric Variability

NASA Astrophysics Data System (ADS)

Littlefield, Colin; Garnavich, Peter; Marion, G. H. Howie; Vinkó, József; McClelland, Colin; Rettig, Terrence; Wheeler, J. Craig

2012-06-01

We report the serendipitous discovery of a heavily reddened Wolf-Rayet star that we name WR 142b. While photometrically monitoring a cataclysmic variable, we detected weak variability in a nearby field star. Low-resolution spectroscopy revealed a strong emission line at 7100 Å, suggesting an unusual object and prompting further study. A spectrum taken with the Hobby-Eberly Telescope confirms strong He II emission and an N IV 7112 Å line consistent with a nitrogen-rich Wolf-Rayet star of spectral class WN6. Analysis of the He II line strengths reveals no detectable hydrogen in WR 142b. A blue-sensitive spectrum obtained with the Large Binocular Telescope shows no evidence for a hot companion star. The continuum shape and emission line ratios imply a reddening of E(B - V) = 2.2-2.6 mag. We estimate that the distance to WR 142b is 1.4 ± 0.3 kpc.

A closer look at associations between hospital leadership walkrounds and patient safety climate and risk reduction: a cross-sectional study.

PubMed

Schwendimann, René; Milne, Judy; Frush, Karen; Ausserhofer, Dietmar; Frankel, Allan; Sexton, J Bryan

2013-01-01

Leadership walkrounds (WRs) are widely used in health care organizations to improve patient safety. This retrospective, cross-sectional study evaluated the association between WRs and caregiver assessments of patient safety climate and patient safety risk reduction across 49 hospitals in a nonprofit health care system. Linear regression analyses using units' participation in WRs were conducted. Survey results from 706 hospital units revealed that units with ≥ 60% of caregivers reporting exposure to at least 1 WR had a significantly higher safety climate, greater patient safety risk reduction, and a higher proportion of feedback on actions taken as a result of WRs compared with those units with <60% of caregivers reporting exposure to WRs. WR participation at the unit level reflects a frequency effect as a function of units with none/low, medium, and high leadership WR exposure.

Relationships among condition indices, feeding and growth of walleye in Lake Erie

USGS Publications Warehouse

Hartman, K.J.; Margraf, F.J.

2006-01-01

Condition indices are often used as surrogates of fish health, growth, and feeding and to compare ecological well-being among fish populations. In an effort to identify easily measured indices, growth and food consumption were compared with gonadal-somatic index, liver-somatic index (LSI), fat-somatic index and relative weight (Wr) for ages 1-3 walleye, Sander vitreus (Mitchill), in Lake Erie from 1986 to 1988. The LSI and Wr were significantly correlated with growth rate or food consumption, but correlations were too small to be considered biologically meaningful. Furthermore, no consistent relationships between condition indices and growth or consumption were found among combinations of fish age and season. None of the indices are considered reliable surrogates for more laborious estimates of growth and food consumption for Lake Erie walleye. Significant relationships between Wr and relative abundance of key prey species warrant further investigation. ?? 2006 Blackwell Publishing Ltd.

The first orbital solution for the massive colliding-wind binary HD 93162 (≡WR 25)

NASA Astrophysics Data System (ADS)

Gamen, R.; Gosset, E.; Morrell, N.; Niemela, V.; Sana, H.; Nazé, Y.; Rauw, G.; Barbá, R.; Solivella, G.

2006-12-01

Context: Since the discovery, with the EINSTEIN satellite, of strong X-ray emission associated with HD 93162 (≡WR 25), this object has been predicted to be a colliding-wind binary system. However, radial-velocity variations that would prove the suspected binary nature have yet to be found. Aims: We spectroscopically monitored this object to investigate its possible variability to address this discordance. Methods: We compiled the largest available radial-velocity data set for this star to look for variations that might be due to binary motion. We derived radial velocities from spectroscopic data acquired mainly between 1994 and 2006, and searched these radial velocities for periodicities using different numerical methods. Results: For the first time, periodic radial-velocity variations are detected. Our analysis definitively shows that the Wolf-Rayet star WR 25 is an eccentric binary system with a probable period of about 208 days.

Spectral Identification of New Galactic cLBV and WR Stars

NASA Astrophysics Data System (ADS)

Stringfellow, G. S.; Gvaramadze, V. V.; Beletsky, Y.; Kniazev, A. Y.

2012-12-01

We have undertaken a near-IR spectral survey of stars associated with compact nebulae recently revealed by the Spitzer and WISE imaging surveys. These circumstellar nebulae, produced by massive evolved stars, display a variety of symmetries and shapes and are often only evident at mid-IR wavelengths. Stars associated with ˜50 of these nebulae have been observed. We also obtained recent spectra of previously confirmed (known) luminous blue variables (LBVs) and candidate LBVs (cLBVs). The spectral similarity of the stars observed when compared directly to known LBVs and Wolf-Rayet (WR) stars indicate many are newly identified cLBVs, with a few being newly discovered WR stars, mostly of WN8-9h spectral type. These results suggest that a large population of previously unidentified cLBVs and related transitional stars reside in the Galaxy and confirm that circumstellar nebulae are inherent to most (c)LBVs.

Research on wire rope stress distribution of WR-CVT

NASA Astrophysics Data System (ADS)

Zhang, Wu; Guo, Wei; Zhang, Chuanwei; Lu, Zhengxiong; Xu, Xiaobin

2017-10-01

A wire rope continuously variable transmissions (WR-CVT) has been introduced in the paper, in view of its less research, this paper mainly studied the stress distribution of 6×7+IWS bending wire rope. The results shown that the wire stress is layered distribution in each section, the stress at the outer strand center wire and outer strand side wire was the greatest, the stress value of the outer strand side wire and metal block circular notch is second. As the transmission ratio decreases, the wire stress decreases, which is related to the pulley working radius increases. Compared with the section A1, the stress value on the section A2 is smaller, mainly because the section A2 is not in contact with the metal block or the contact pressure is small. This study provides a basis for the study of fatigue and wears failure of WR-CVT components.

A spectroscopic survey of the WNL stars in the Large Magellanic Cloud: General properties and binary status

NASA Astrophysics Data System (ADS)

Schnurr, Olivier

2008-09-01

This thesis presents the results of an intense, spectroscopic survey of 41 of the 47 known, late-type, nitrogen-rich Wolf-Rayet (WR) stars in the Large Magellanic Cloud (LMC) which could be observed with ground-based, optical telescopes. For the study of the remaining 6 WNL located in the extremely dense central object of 30 Dor, R136, adaptive-optics assisted, near-infrared spectroscopy was required. The results of this study will be published elsewhere. Our survey concludes the decade-long effort of the Montreal Massive-Star Group to monitor all known WR stars in the Magellanic Clouds for radial-velocity (RV) variations due to binarity, a point which has been debated since the true, evolved nature of WR stars has been recognized in the late 1960s. From model calculations, it was expected that with decreasing metallicity, the binary frequency among WR stars increases, or otherwise the progenitor stars could not have turned into a WR star. Our survey set out to observationally test this assumption. After summarizing the general importance of massive stars, we describe the spectroscopic observations of our program stars. We then detail the data analysis process, which encompasses careful calibration and proper choice of RV standards. We also include publicly available, visible and X-ray photometric data in our analysis. We are able to identify four previously unknown binaries in our sample, bringing the total number of known WNL binaries in the LMC to only nine. As a direct result, we question the assumption that binarity is required to form WR stars at lower metallicity. At least some of the hydrogen-containing WNL stars in our sample seem not to be genuine, evolved, helium-burning WR stars, but rather unevolved, hydrogen- burning objects. There is ample evidence that some of these stars are the most massive stars known. As a second and most remarkable result, all but one of our nine binaries harbor such extreme objects; this greatly enlarges the sample of such known binaries, and paves the way for an independent mass determination via Keplerian orbits in further studies, some of which we have already initiated. The results of those studies will be crucial for calibrating stellar models. One of these binaries, R145, is then studied in greater detail, combining previously published and unpublished data with ours, to present, for the first time, a full set of orbital parameters for both components of the binary system. Since we also determine the orbital inclination angle, we are able to derive the absolute masses of this extreme object. It is found that R145 very likely harbors the most massive star known and properly "weighed" so far.

[Effect of straw-returning on the storage and distribution of different active fractions of soil organic carbon].

PubMed

Wang, Hul; Wang, Xu-dong; Tian, Xiao-hong

2014-12-01

The impacts of straw mulching and returning on the storage of soil dissolved organic carbon (DOC), particulate organic carbon (POC) and mineral associated organic carbon (MOC), and their proportions to the total organic carbon (TOC) were studied based on a field experiment. The results showed that compared to the treatment of wheat straw soil-returning (WR), the storage of TOC and MOC decreased by 4.1% and 9.7% respectively in 0-20 cm soil in the treatment with wheat straw mulching (WM), but the storage of DOC and POC increased by 207.7% and 11.9%, and TOC and POC increased significantly in 20-40 cm soil. Compared to the treatment with maize straw soil-returning (MR), the storage of TOC and MOC in the plough pan soil of the treatment with maize straw mulching (MM) increased by 13.6% and 14.6% , respectively. Compared to the WR-MR treatment, the storage of TOC and MOC in top soil (0-20 icm) significantly decreased by 8.5% and 10.3% respectively in WM-MM treatment. The storage of TOC, and POC in top soil was significantly higher in the treatments with maize straw soil-returning or mulching than that with wheat straw. Compared to the treatment without straw (CK), the storage of TOC in top soil increased by 5.2% to 18.0% in the treatments with straw returning or mulching in the six modes (WM, WR, MM, MR, WM-MM,WR-MR) (P<0.05), but the storage of TOC in the plough pan soil decreased by 8.0% to 11.5% (P<0.05) except for the treatments of WM and MM. The storage of DOC and DOC/TOC ratio decreased significantly in top soil in the treatments with straw mulching or returning in six modes. The storage of POC and POC/TOC ratio in WM and WM-MM treatments, MOC and MOC/TOC ratio in WR treatment, increased significantly in top soil. In the other three treatments with straw mulching and returning (MM, MR, WR-MR), the storage of POC and MOC increased significantly in top soil. These results suggested that straw mulching had the potential to accumulate active organic carbon fraction in soil, straw soil-returning had the potential to accumulate stable organic carbon fraction. Considering organic carbon sequestration in cropland in the region of Guanzhong plain, maize straw mulching or soil-returning was better than wheat straw, and wheat straw and maize straw soil-returning (WR-MR) were better than wheat and maize straw mulching (WM-MM).

Soil suppressiveness to fusarium disease: shifts in root microbiome associated with reduction of pathogen root colonization.

PubMed

Klein, Eyal; Ofek, Maya; Katan, Jaacov; Minz, Dror; Gamliel, Abraham

2013-01-01

Soil suppressiveness to Fusarium disease was induced by incubating sandy soil with debris of wild rocket (WR; Diplotaxis tenuifolia) under field conditions. We studied microbial dynamics in the roots of cucumber seedlings following transplantation into WR-amended or nonamended soil, as influenced by inoculation with Fusarium oxysporum f. sp. radicis-cucumerinum. Disease symptoms initiated in nonamended soil 6 days after inoculation, compared with 14 days in WR-amended soil. Root infection by F. oxysporum f. sp. radicis-cucumerinum was quantified using real-time polymerase chain reaction (PCR). Target numbers were similar 3 days after inoculation for both WR-amended and nonamended soils, and were significantly lower (66%) 6 days after inoculation and transplanting into the suppressive (WR-amended) soil. This decrease in root colonization was correlated with a reduction in disease (60%) 21 days after inoculation and transplanting into the suppressive soil. Fungal community composition on cucumber roots was assessed using mass sequencing of fungal internal transcribed spacer gene fragments. Sequences related to F. oxysporum, Fusarium sp. 14005, Chaetomium sp. 15003, and an unclassified Ascomycota composed 96% of the total fungal sequences in all samples. The relative abundances of these major groups were highly affected by root inoculation with F. oxysporum f. sp. radicis-cucumerinum, with a 10-fold increase in F. oxysporum sequences, but were not affected by the WR amendment. Quantitative analysis and mass-sequencing methods indicated a qualitative shift in the root's bacterial community composition in suppressive soil, rather than a change in bacterial numbers. A sharp reduction in the size and root dominance of the Massilia population in suppressive soil was accompanied by a significant increase in the relative abundance of specific populations; namely, Rhizobium, Bacillus, Paenibacillus, and Streptomyces spp. Composition of the Streptomyces community shifted significantly, as determined by PCR denaturing gradient gel electrophoresis, resulting in an increase in the dominance of a specific population in suppressive soils after only 3 days. This shift was related mainly to the increase in Streptomyces humidus, a group previously described as antagonistic to phytopathogenic fungi. Thus, suitable soil amendment resulted in a shift in the root's bacterial communities, and infection by a virulent pathogen was contained by the root microbiome, leading to a reduced disease rate.

Temporal dissociation between muscle and pulmonary oxygen uptake kinetics: influences of perfusion dynamics and arteriovenous oxygen concentration differences in muscles and lungs.

PubMed

Drescher, U; Koschate, J; Thieschäfer, L; Schneider, S; Hoffmann, U

2018-06-22

The aim of the study was to test whether or not the arteriovenous oxygen concentration difference (avDO 2 ) kinetics at the pulmonary (avDO 2 pulm) and muscle (avDO 2 musc) levels is significantly different during dynamic exercise. A re-analysis involving six publications dealing with kinetic analysis was utilized with an overall sample size of 69 participants. All studies comprised an identical pseudorandom binary sequence work rate (WR) protocol-WR changes between 30 and 80 W-to analyze the kinetic responses of pulmonary ([Formula: see text]) and muscle ([Formula: see text]) oxygen uptake kinetics as well as those of avDO 2 pulm and avDO 2 musc. A significant difference between [Formula: see text] (0.395 ± 0.079) and [Formula: see text] kinetics (0.330 ± 0.078) was observed (p < 0.001), where the variables showed a significant relationship (r SP  = 0.744, p < 0.001). There were no significant differences between avDO 2 musc (0.446 ± 0.077) and avDO 2 pulm kinetics (0.451 ± 0.075), which are highly correlated (r = 0.929, p < 0.001). It is suggested that neither avDO 2 pulm nor avDO 2 musc kinetic responses seem to be responsible for the differences between estimated [Formula: see text] and measured [Formula: see text] kinetics. Obviously, the conflation of avDO 2 and perfusion ([Formula: see text] ) at different points in time and at different physiological levels drive potential differences in [Formula: see text] and [Formula: see text] kinetics. Therefore, [Formula: see text] should, in general, be considered whenever oxygen uptake kinetics are analyzed or discussed.

A Literature Review on the Mechanism of Action of Sulphur and Nitrogen Mustard

DTIC Science & Technology

1989-07-01

for years is also poeqible (Aasted et al, 1987; Colardyn et al, 1986). Severely poisoned individuals exhibit bone marrow depression and may die from...MMS does not produce the enhanced depression of DNA synthesis in sensitive cells, compared to resistant cells, produced by sulphur mustard and...Compound MATD 1 Protection (mg/mouse) index 2 WR-3689 15 159 WR-2721 15 44 Aminoethylcysteine 80 27 N- acetylcysteine 8 26 Glutathione 60 22 Cysteine 8

Spatial and temporal variation in proportional stock density and relative weight of smallmouth bass in a reservoir

USGS Publications Warehouse

Mesa, Matthew G.; Duke, S.D.; Ward, David L.

1990-01-01

Population data for smallmouth bass Micropterus dolomieui in 20,235 ha John Day Reservoir on the Columbia River were used to (1) determine whether Proportional Stock Density (PSD) and Relative Weight (Wr) varied spatially and temporally in two areas of the reservoir with established smallmouth bass fisheries; (2) explore possible causes of any observed variation; and (3) discuss some management implications and recommendations. Both PSD and Wr varied spatially and monthly in all years examined. On an annual basis, PSD varied at one area but not at the other, whereas Wr showed little variation. Possible explanations for the variation in PSD and Wr are differences in growth, mortality, recruitment, and exploitation. Our data suggested that regulations established or changed on a reservoir-wide basis may have different effects on the fishery, depending on location in the reservoir. Also, pooling data from various areas within a reservoir to yield point estimates of structural indices may not represent the variation present in the population as a whole. The significant temporal variability reflects the importance of determining the proper time to sample fish to yield representative estimates of the variable of interest. In areas with valuable fisheries or markedly different population structures, we suggest that an area-specific approach be made to reservoir fishery management, and that efforts be made toward effecting consistent harvest regulations in interstate waters.

Revealing the nebular properties and Wolf-Rayet population of IC10 with Gemini/GMOS

NASA Astrophysics Data System (ADS)

Tehrani, Katie; Crowther, Paul A.; Archer, I.

2017-12-01

We present a deep imaging and spectroscopic survey of the Local Group irregular galaxy IC10 using Gemini North and GMOS to unveil its global Wolf-Rayet (WR) population. We obtain a star formation rate (SFR) of 0.045 ± 0.023 M⊙ yr-1, for IC10 from the nebular H α luminosity, which is comparable to the Small Magellanic Cloud. We also present a revised nebular oxygen abundance of log(O/H) + 12 = 8.40 ± 0.04, comparable to the LMC. It has previously been suggested that for IC10 to follow the WR subtype-metallicity dependance seen in other Local Group galaxies, a large WN population awaits discovery. Our search revealed three new WN stars, and six candidates awaiting confirmation, providing little evidence to support this claim. The new global WR star total of 29 stars is consistent with the Large Magellanic Cloud population when scaled to the reduced SFR of IC10. For spectroscopically confirmed WR stars, the WC/WN ratio is lowered to 1.0; however, including all potential candidates, and assuming those unconfirmed to be WN stars, would reduce the ratio to ∼0.7. We attribute the high WC/WN ratio to the high star formation surface density of IC10 relative to the Magellanic Clouds, which enhances the frequency of high-mass stars capable of producing WC stars.

A new molecular targeted therapeutic approach for renal cell carcinoma with a p16 functional peptide using a novel transporter system.

PubMed

Zennami, Kenji; Yoshikawa, Kazuhiro; Kondo, Eisaku; Nakamura, Kogenta; Upsilonamada, Yoshiaki; De Velasco, Marco A; Tanaka, Motoyoshi; Uemura, Hirotsugu; Shimazui, Toru; Akaza, Hideyuki; Saga, Shinsuke; Ueda, Ryuzo; Honda, Nobuaki

2011-08-01

Molecular targeting agents have become formidable anticancer weapons showing much promise against refractory tumors and functional peptides and are among the more desirable of these nanobio-tools. Intracellular delivery of multiple functional peptides forms the basis for a potent, non-invasive mode of delivery, providing distinctive therapeutic advantages. We examine the growth suppression efficiency of human renal cell carcinoma (RCC) by single-peptide targeting. We simultaneously introduced p16INK4a tumor suppressor peptides by Wr-T-mediated peptide delivery. Wr-T-mediated transport of p16INK4a functional peptide into 10 RCC lines, lacking expression of the p16INK4a molecule, reversed the specific loss of p16 function, thereby drastically inhibiting tumor growth in all but 3 lines by >95% within the first 96 h. In vivo analysis using SK-RC-7 RCC xenografts in nude mice demonstrated tumor growth inhibition by the p16INK4a peptide alone, however, inoculation of Wr-T and the p16INK4a functional peptide mixture, via the heart resulted in complete tumor regression. Thus, restoration of tumor suppressor function with Wr-T peptide delivery represents a powerful approach, with mechanistic implications for the development of efficacious molecular targeting therapeutics against intractable RCC.

On the Origin and Evolution of Wolf-Rayet Central Stars of Planetary Nebulae

NASA Astrophysics Data System (ADS)

DePew, K. D.

2011-03-01

The origin of hydrogen-deficiency in the central stars of planetary nebulae (CSPNe) is currently a topic of heated debate. This class of objects is comprised of Wolf-Rayet ([WR]) stars, weak emission-line stars (WELS), and PG 1159 stars, each differentiated by a set of unique spectral characteristics. For some time, there have been questions surrounding the evolutionary status of these rare stars: what environmental conditions, such as chemical abundances, are necessary for their emergence, whether any of them represent different stages of development in the same class of stars, and what the characteristics of their progenitors may be. However, such investigations have been hampered by a lack of a sufficient number of these stars and their various sub-classes until recently. This thesis presents the significant discovery of 22 new [WR] stars and 10 new WELS, many uncovered specifically during this thesis in the course of the MASH survey and through serendipitous fibre placement during follow-up of MASH objects. All examples have been carefully classified as accurately as possible using the best current available data though for many this remains a preliminary assignment pending deeper spectra. This work expands the known sample of H-deficient stars by 30%, allowing a more detailed study of their properties than previously possible and moving us closer to a more complete census of local H-deficient CSPNe. In the course of our classifications, Abell 48 was found to be a particularly interesting object. Further analysis of nebular chemical abundances, modeled temperature, and ionization state as indicated by the chemical species present suggests that the CSPN of Abell 48 is very similar to the CSPN of PB 8, which has recently been re-designated as the founding member of a new and rare [WN/WC] class (Todt et al. 2010). Its similarity to and differences with other oxygen-rich [WO] and carbon-rich [WC] stars as well as previously identified [WN] stars are examined. All these stars have also been studied in the context of a new subclass-dynamical age relationship that we have also discovered. This major finding is the first to show evidence of an evolutionary trend amongst the [WR] population and was made possible by use of the powerful new surface brightness-radius (SB-r) relation of Frew (2008) that can, at last, provide accurate distances to PN (and hence also their central stars). Key data acquired here as well as modeled effective temperatures and excitation classes of other [WR]s, WELS and PG 1159 central stars found in the literature were also utilized in generating this relationship. Finally, continuing with the SB-r relation, the scale heights of the most complete available sample of [WR], WELS and PG 1159 CS populations are determined and compared. These data show that both WELS and PG 1159 stars are found to possess significantly higher Galactic heights than the members of the [WR] class, implying that PG 1159s do not all descend from [WR]s, and that WELS are not evolutionarily related to [WR]s. This is another major finding of this work. It is possible, however, that the WELS class, and perhaps the PG 1159 class as well, are heterogeneous groups.

Forming short-period Wolf-Rayet X-ray binaries and double black holes through stable mass transfer

NASA Astrophysics Data System (ADS)

van den Heuvel, E. P. J.; Portegies Zwart, S. F.; de Mink, S. E.

2017-11-01

We show that black hole high-mass X-ray binaries (HMXBs) with O- or B-type donor stars and relatively short orbital periods, of order one week to several months may survive spiral-in, to then form Wolf-Rayet (WR) X-ray binaries with orbital periods of order a day to a few days; while in systems where the compact star is a neutron star, HMXBs with these orbital periods never survive spiral-in. We therefore predict that WR X-ray binaries can only harbour black holes. The reason why black hole HMXBs with these orbital periods may survive spiral-in is: the combination of a radiative envelope of the donor star and a high mass of the compact star. In this case, when the donor begins to overflow its Roche lobe, the systems are able to spiral in slowly with stable Roche lobe overflow, as is shown by the system SS433. In this case, the transferred mass is ejected from the vicinity of the compact star (so-called isotropic re-emission mass-loss mode, or SS433-like mass-loss), leading to gradual spiral-in. If the mass ratio of donor and black hole is ≳3.5, these systems will go into common-envelope evolution and are less likely to survive. If they survive, they produce WR X-ray binaries with orbital periods of a few hours to one day. Several of the well-known WR+O binaries in our Galaxy and the Magellanic Clouds, with orbital periods in the range between a week and several months, are expected to evolve into close WR-black hole binaries, which may later produce close double black holes. The galactic formation rate of double black holes resulting from such systems is still uncertain, as it depends on several poorly known factors in this evolutionary picture. It might possibly be as high as ˜10-5 yr-1.

A Comparison of Wind Speed Data from Mechanical and Ultrasonic Anemometers

NASA Technical Reports Server (NTRS)

Short, D.; Wells, L.; Merceret, F.; Roeder, W. P.

2006-01-01

This study compared the performance of mechanical and ultrasonic anemometers at the Eastern Range (ER; Kennedy Space Center and Cape Canaveral Air Force Station on Florida's Atlantic coast) and the Western Range (WR; Vandenberg Air Force Base on California's Pacific coast). Launch Weather Officers, forecasters, and Range Safety analysts need to understand the performance of wind sensors at the ER and WR for weather warnings, watches, advisories, special ground processing operations, launch pad exposure forecasts, user Launch Commit Criteria (LCC) forecasts and evaluations, and toxic dispersion support. The current ER and WR weather tower wind instruments are being changed from the current propeller-and-vane (ER) and cup-and-vane (WR) sensors to ultrasonic sensors through the Range Standardization and Automation (RSA) program. The differences between mechanical and ultrasonic techniques have been found to cause differences in the statistics of peak wind speed in previous studies. The 45th Weather Squadron (45 WS) and the 30th Weather Squadron (30 WS) requested the Applied Meteorology Unit (AMU) to compare data between RSA and current sensors to determine if there are significant differences. Approximately 3 weeks of Legacy and RSA wind data from each range were used in the study, archived during May and June 2005. The ER data spanned the full diurnal cycle, while the WR data was confined to 1000-1600 local time. The sample of 1-minute data from numerous levels on 5 different towers on each range totaled more than 500,000 minutes of data (482,979 minutes of data after quality control). The 10 towers were instrumented at several levels, ranging from 12 ft to 492 ft above ground level. The RSA sensors were collocated at the same vertical levels as the present sensors and typically within 15 ft horizontally of each another. Data from a total of 53 RSA ultrasonic sensors, collocated with present sensors were compared. The 1-minute average wind speed/direction and the 1-second peak wind speed/direction were compared.

Non-fatal work-related motor vehicle traffic crash injuries in New Zealand: analysis of a national claims database.

PubMed

Sultana, Shaheen; Robb, Gillian; Ameratunga, Shanthi; Jackson, Rod T

2007-12-14

This study describes event rates and associated costs from non-fatal work-related motor vehicle traffic crash (WR MVTC) injuries on public roads in New Zealand based on an analysis of the Accident Compensation Corporation (ACC) entitlement claims database. WR MVTC injury claims between July 2004 and June 2006 were identified from the ACC Motor Vehicle Account. Cross-sectional analyses were performed to describe the characteristics of the claims. Injury rates were estimated where appropriate. The overall age-standardised rate of non-fatal WR MVTC injury claims during the study period was 109 per 100,000 workers per year. The majority of claimants were male (75%) and New Zealand (NZ) European (67%), and one in three of these injuries occurred among plant and machine operators and assemblers. In contrast to rates of road traffic injury resulting in deaths and hospital admissions in NZ, younger and older workers had similar proportionate representation in the claims data. The total cost associated with the 1968 claims made during the 12 months from July 2004 to June 2005 was approximately NZ$6 million, with an average cost per claim of NZ$2884. To our knowledge this is the first published analysis of non-fatal WR MVTC injury claims in New Zealand. These analyses identify industry and demographic groups that appear to be at increased risk of WR MVTC injuries that could be targeted for preventive interventions. However, a number of limitations in the database, including uncertainties regarding the definition and coding of crashes deemed as "work-related", under-reporting of claims, and lack of a reliable indicator of injury severity significantly compromised our ability to interpret the results. Considerable improvement in the quality and reporting of claims data is required to facilitate the utility of this information to inform injury prevention strategies.

Role of right ventricle and dynamic pulmonary hypertension on determining ΔVO2/ΔWork Rate flattening: insights from cardiopulmonary exercise test combined with exercise echocardiography.

PubMed

Bandera, Francesco; Generati, Greta; Pellegrino, Marta; Donghi, Valeria; Alfonzetti, Eleonora; Gaeta, Maddalena; Villani, Simona; Guazzi, Marco

2014-09-01

Several cardiovascular diseases are characterized by an impaired O2 kinetic during exercise. The lack of a linear increase of Δoxygen consumption (VO2)/ΔWork Rate (WR) relationship, as assessed by expired gas analysis, is considered an indicator of abnormal cardiovascular efficiency. We aimed at describing the frequency of ΔVO2/ΔWR flattening in a symptomatic population of cardiac patients, characterizing its functional profile, and testing the hypothesis that dynamic pulmonary hypertension and right ventricular contractile reserve play a major role as cardiac determinants. We studied 136 patients, with different cardiovascular diseases, referred for exertional dyspnoea. Cardiopulmonary exercise test combined with simultaneous exercise echocardiography was performed using a symptom-limited protocol. ΔVO2/ΔWR flattening was observed in 36 patients (group A, 26.5% of population) and was associated with a globally worse functional profile (reduced peak VO2, anaerobic threshold, O2 pulse, impaired VE/VCO2). At univariate analysis, exercise ejection fraction, exercise mitral regurgitation, rest and exercise tricuspid annular plane systolic excursion, exercise systolic pulmonary artery pressure, and exercise cardiac output were all significantly (P<0.05) impaired in group A. The multivariate analysis identified exercise systolic pulmonary artery pressure (odds ratio, 1.06; confidence interval, 1.01-1.11; P=0.01) and exercise tricuspid annular plane systolic excursion (odds ratio, 0.88; confidence interval, 0.80-0.97; P=0.01) as main cardiac determinants of ΔVO2/ΔWR flattening; female sex was strongly associated (odds ratio, 6.10; confidence interval, 2.11-17.7; P<0.01). In patients symptomatic for dyspnea, the occurrence of ΔVO2/ΔWR flattening reflects a significantly impaired functional phenotype whose main cardiac determinants are the excessive systolic pulmonary artery pressure increase and the reduced peak right ventricular longitudinal systolic function. © 2014 American Heart Association, Inc.

Abnormal end-tidal PO(2) and PCO(2) at the anaerobic threshold correlate well with impaired exercise gas exchange in patients with left ventricular dysfunction.

PubMed

Kano, Hiroto; Koike, Akira; Hoshimoto-Iwamoto, Masayo; Nagayama, Osamu; Sakurada, Koji; Suzuki, Takeya; Tsuneoka, Hidekazu; Sawada, Hitoshi; Aizawa, Tadanori; Wasserman, Karlman

2012-01-01

The aim of the present study was to compare the end-tidal O(2) pressure (PETO(2)) to end-tidal CO(2) pressure (PETCO(2)) in cardiac patients during rest and during 2 states of exercise: at anaerobic threshold (AT) and at peak. The purpose was to see which metabolic state, PETO(2) or PETCO(2), best correlated with exercise limitation. Thirty-eight patients with left ventricular (LV) ejection fraction <40% underwent cardiopulmonary exercise testing (CPX). PETO(2) and PETCO(2) were measured during CPX, along with peak O(2) uptake (VO(2)), AT, slope of the increase in ventilation (VE) relative to the increase in CO(2) output (VCO(2)) (VE vs. VCO(2) slope), and the ratio of the increase in VO(2) to the increase in work rate (ΔVO(2)/ΔWR). Both PETO(2) and PETCO(2) measured at AT were best correlated with peakVO(2), AT, ΔVO(2)/ΔWR and VE vs. VCO(2) slope. PETO(2) at AT correlated with reduced peak VO(2) (r=-0.60), reduced AT (r=-0.52), reduced ΔVO(2)/ΔWR (r=-0.55) and increased VE vs. VCO(2) slope (r=0.74). PETCO(2) at AT correlated with reduced peak VO(2) (r=0.67), reduced AT (r=0.61), reduced ΔVO(2)/ΔWR (r=0.58) and increased VE vs. VCO(2) slope (r=-0.80). PETCO(2) and PETO(2) at AT correlated with peak VO(2), AT and ΔVO(2)/ΔWR, but best correlated with increased VE vs. VCO(2) slope. PETO(2) and PETCO(2) at AT can be used as a prime index of impaired cardiopulmonary function during exercise in patients with LV failure.

A new Wolf-Rayet star and its circumstellar nebula in Aquila

NASA Astrophysics Data System (ADS)

Gvaramadze, V. V.; Kniazev, A. Y.; Hamann, W.-R.; Berdnikov, L. N.; Fabrika, S.; Valeev, A. F.

2010-04-01

We report the discovery of a new Wolf-Rayet star in Aquila via detection of its circumstellar nebula (reminiscent of ring nebulae associated with late WN stars) using the Spitzer Space Telescope archival data. Our spectroscopic follow-up of the central point source associated with the nebula showed that it is a WN7h star (we named it WR121b). We analysed the spectrum of WR121b by using the Potsdam Wolf-Rayet model atmospheres, obtaining a stellar temperature of ~=50kK. The stellar wind composition is dominated by helium with ~20 per cent of hydrogen. The stellar spectrum is highly reddened [E(B - V) = 2.85mag]. Adopting an absolute magnitude of Mv = -5.7, the star has a luminosity of logL/Lsolar = 5.75 and a mass-loss rate of 10-4.7Msolaryr-1, and resides at a distance of 6.3kpc. We searched for a possible parent cluster of WR121b and found that this star is located at ~=1° from the young star cluster embedded in the giant HII region W43 (containing a WN7+a/OB? star - WR121a). We also discovered a bow shock around the O9.5III star ALS9956, located at from the cluster. We discuss the possibility that WR121b and ALS9956 are runaway stars ejected from the cluster in W43. Based on observations collected at the German-Spanish Astronomical Center, Calar Alto, jointly operated by the Max-Planck-Institut für Astronomie Heidelberg and the Instituto de Astrofísica de Andalucía (CSIC). E-mail: vgvaram@mx.iki.rssi.ru (VVG); akniazev@saao.ac.za (AYK); wrh@astro.physik.uni-potsdam.de (WRH); berdnik@sai.msu.ru (LNB); fabrika@sao.ru (SF); azamat@sao.ru (AFV)

The washout rate of (123)I-BMIPP and the evolution of left ventricular function in patients with successfully reperfused ST-segment elevation myocardial infarction: comparisons with the echocardiography.

PubMed

Biswas, Shankar K; Sarai, Masayoshi; Yamada, Akira; Toyama, Hiroshi; Motoyama, Sadako; Harigaya, Hiroto; Hara, Tomonori; Naruse, Hiroyuki; Hishida, Hitoshi; Ozaki, Yukio

2010-02-01

The evolution of the oxidative metabolism of (11)C acetate parallels the recovery of left ventricular(LV) contraction following acute myocardial infarction(AMI). This study was designed to unravel, for the first time, the impact of the global washout rate(WR) of (123)I-beta-methyl-p-iodophenylpentadecanoic acid (BMIPP) on the recovery of LV function followingAMI, as evidenced from conventional echocardiography.Twenty consecutive patients (age: 58 +/- 13 years; 16 males and 4 females) with ST-segment elevation myocardial infarction (STEMI) were enrolled and all of them underwent successful percutaneous coronary intervention (PCI). (123)I-BMIPP cardiac scintigraphy was performed at 7 +/- 3 days after admission. The WR was calculated from the polar map and the regional BMIPP defect score was calculated using a 17 segment model. Echocardiography was performed within 24 h of admission and at 3 months to record the ejection fraction (EF), the wall motion score index (WMSI), the ratio of the mitralinflow velocity to the early diastolic velocity (E/E0)and the myocardial performance index (MPI). The mean global WR of the BMIPP was 22.12 +/- 7.22%, and it was significantly correlated with the improvement of the WMSI (r = 0.61, P\\0.004). However,the relative changes of the EF, E/E0 and MPI were not correlated with the WR. The BMIPP defect score (18 +/- 10) was significantly correlated with the WMSI on admission (r = 0.74, P = 0.0002), but the defect score was not correlated with the relative changes of any of the echocardiographic parameters. We proved that the WR of the BMIPP is a promising indicator of improvement of the LV wall motion (WMSI) following ST-segment elevation myocardial infarction and successful reperfusion.

Soil carbon and nitrogen pools in mid- to late-successional forest stands of the northwestern United States: Potential impact of fire

Treesearch

Deborah S. Page-Dumroese; Martin F. Jurgensen

2006-01-01

When sampling woody residue (WR) and organic matter (OM) present in forest floor, soil wood, and surface mineral soil (0­30 cm) in 14 mid- to late-successional stands across a wide variety of soil types and climatic regimes in the northwestern USA, we found that 44%-84% of carbon (C) was in WR and surface OM, whereas >80% of nitrogen (N) was in the mineral soil. In...

Waveguide Power-Amplifier Module for 80 to 150 GHz

NASA Technical Reports Server (NTRS)

Samoska, Lorene; Weinreb, Sander; Peralta, Alejandro

2006-01-01

A waveguide power-amplifier module capable of operating over the frequency range from 80 to 150 GHz has been constructed. The module comprises a previously reported power amplifier packaged in a waveguide housing that is compatible with WR-8 waveguides. (WR- 8 is a standard waveguide size for the nominal frequency range from 90 to 140 GHz.) The waveguide power-amplifier module is robust and can be bolted to test equipment and to other electronic circuits with which the amplifier must be connected for normal operation.

Observations of Nonthermal Radio Emission from Early-type Stars

NASA Technical Reports Server (NTRS)

Abbott, D. C.; Bieging, J. H.; Churchwell, E.

1985-01-01

As a part of a wider survey of radio emission from O, B, and Wolf-Rayet (WR) stars, five new stars whose radio emission is dominated by a nonthermal mechanism of unknown origin were discovered. From statistics of distance-limited samples of stars, it is estimated that the minimum fraction of stars which are nonthermal emitters is 25% for the OB stars and 10% for the WR stars. The characteristics of this new class of nonthermal radio emitter are investigated.

Preparation of Radiochemical-Labeled Compounds for the U.S. Army Drug Development Program

DTIC Science & Technology

1992-04-20

hydrochloric acid , b) extraction with ether, c) basification with potassium carbonate, d extraction with ether. 2. The crude product was isolated by...Chloride Fisher A-575 880667 Nethylene Chloride Fisher D-37 913251 Alumina, basic Act.I Woelm B 1385 Ethylene Natheson 08227 Hydrochloric Acid Fisher A...4-14C]WR-242511) and [!6- 14C]ertelinic acid were coupleted. A total of 31 m~i of (414 ]WR-238605 was prepared with specific activity of 21 mCi

Six Month Oral Toxicity Study of WR238605 Succinate in Rats. Volume 1

DTIC Science & Technology

1996-02-02

expressed on the basis of mg base/kg/day. Statistical analyses was performed on an IBM • compatible computer using the commercially available LabCat... iTP (F) tA/G *BUN tTBA(M/F?) Hematology1 NE *RBC(F) iHCT(F) *HGB(F) tMETHGB *PLT(M) i RBC...1 A-2 Part 1: Identity, Purity and Stability of Neat WR238605 Succinate 0bjttaTO IBM ! The objective of this study was to confirm the identity and

The long period Wolf-Rayet star HD193077

NASA Astrophysics Data System (ADS)

Annuk, Kalju

Radial velocities of HD193077 have been measured on 76 spectra obtained during 1980-1987. It has been found that the period of this WR binary star is about 1538 days. A new derived orbital solution yields an eccentric orbit, e = 0.3, and the mass function, f(m) = 4.54 solar masses, is typical of WR+O binaries. By analysis of radial velocity residuals, no short periodic variations were found, as it was suggested by Lamontagne et al. (1982).

Synthesis of gold nanoparticles on multi-walled carbon nanotubes (Au-MWCNTs) via deposition precipitation method

NASA Astrophysics Data System (ADS)

Zulikifli, Farah Wahida Ahmad; Yazid, Hanani; Halim, Muhammad Zikri Budiman Abdul; Jani, Abdul Mutalib Md

2017-09-01

Carbon nanotubes (CNTs) have received impressive consideration as support materials of noble metal catalysts in heterogeneous catalysis due to their good mechanical strength, large surface area and good durability under harsh conditions. The interaction between CNTs and noble metal nanoparticles (NPs) gives an unusual unique microstructure properties and or modification of the electron density of the noble metal clusters, and enhances the catalytic activity. In this study, the MWCNTs were first treated with a mixture of concentrated sulfuric and nitric acid by sonication to improve its dispersibility and to introduce the carboxylic (-COOH) groups on CNTs surfaces. Gold nanoparticles (Au NPs) on multiwalled carbon nanotubes (MWCNTs) were synthesized by the deposition precipitation (DP) method as this method is simpler, low cost, and excellent method. Then, the effect of reducing agent (NaBH4) on gold distribution on the support of MWCNTs was also studied. Dispersion test, Fourier Transform Infrared spectroscopy (FTIR) and Field Emission Scanning Electron Microscope (FESEM) are all used to characterize the functionalized MWCNTs (fCNTs) and the Au NPs-fCNTs catalyst. There are three important peaks in functionalized MWCNTs which correspond to C=O, O-H, and C-O absorption peaks, as a result of the oxidation of COOH groups on the surface of CNTs. The absorption band at 1717 cm-1 is corresponded to C=O stretching of COOH, while the absorption bands at 3384 cm-1 and 1011cm-1 are associated with O-H bending and C-O stretching, respectively. Surface morphology of Au NPs-fCNTs R4 and Au NPs- fCNTs WR catalyst by FESEM showed that the Au NPs of 19.22 ± 2.33 nm and 23.05 ± 2.57 nm size were successfully deposited on CNTs, respectively.

Time-resolved interaction of seawater with gabbro: An experimental study of rare-earth element behavior up to 475 °C, 100 MPa

NASA Astrophysics Data System (ADS)

Beermann, Oliver; Garbe-Schönberg, Dieter; Bach, Wolfgang; Holzheid, Astrid

2017-01-01

High metal and rare-earth element (REE) concentrations with unusual ('atypical') normalized REE patterns are documented in fluids from active hydrothermal vent fields on the Mid-Atlantic Ridge, 5°S and the East Scotia Ridge. Those fluids show relative enrichment of middle heavy REEs and almost no Eu anomalies in chondrite-normalized patterns. To understand the processes that produce such atypical REE patterns we ran a series of experiments, in which natural bottom seawater or aqueous solutions (NaCl, NaCl-MgCl2, or NaCl-CaCl2) were reacted with gabbro and gabbro mineral assemblages from 300 to 475 °C and 40 and 100 MPa. These P-T conditions are representative for water-rock interactions in hydrothermal root and discharge zones. Fluid flux variability and kinetics were addressed in the experiments by varying the water-to-rock mass ratio (w/r) from 0.5-10 and using different run durations from 3-720 h. Only seawater and synthetic MgCl2-bearing fluid mobilized significant amounts of REEs, Si, Ca, Fe, and Mn from gabbro, from clinopyroxene, and from plagioclase. At 425 °C and 40 MPa, fluids were initially acidic with pH (25 °C) of ∼2 increasing to values between ∼4 and 7 upon progressing reactions. Rare earth element and Fe contents peaked within 3-6 h after interaction with gabbroic mineral grains (125-500 μm) at w/r of 5 (REEs) and 2-5 (Fe) but decreased with continuing reaction without strong REE fractionation. Most of the REEs that were leached from primary minerals and dissolved in the fluids early became redeposited into solid reaction products after 720 h. Contents of dissolved SiO2 were pressure-dependent, being about twofold higher at 100 MPa than at 40 MPa (425 °C) and were below quartz saturation with gabbro and clinopyroxene as solid starting material and close to quartz saturation with plagioclase reactant. However, Si in fluids from the rock-dominated experiments at 100 MPa with gabbro (w/r 0.5-1) dropped to very low contents. A concomitant decrease in chlorinity suggests that these changes may be due to the breakdown of olivine and the formation of serpentine and Fe-hydroxy chlorides. Regardless of the starting solid reactants, fluid REE patterns were dominantly controlled by w/r. Atypical fluid REE patterns and high fluid REE contents were obtained at high w/r (⩾5). Whereas typical REE patterns known from many mid-ocean ridge vent fluids, showing relative enrichments of light REEs and a positive Eu anomaly, were obtained at low w/r of 0.5-1. Our results hence clearly show that REE contents and patterns of vent fluids are sensitive to variations in the w/r.

Active vaccination with vaccinia virus A33 protects mice against lethal vaccinia and ectromelia viruses but not against cowpoxvirus; elucidation of the specific adaptive immune response.

PubMed

Paran, Nir; Lustig, Shlomo; Zvi, Anat; Erez, Noam; Israely, Tomer; Melamed, Sharon; Politi, Boaz; Ben-Nathan, David; Schneider, Paula; Lachmi, Batel; Israeli, Ofir; Stein, Dana; Levin, Reuven; Olshevsky, Udy

2013-07-10

Vaccinia virus protein A33 (A33VACV) plays an important role in protection against orthopoxviruses, and hence is included in experimental multi-subunit smallpox vaccines. In this study we show that single-dose vaccination with recombinant Sindbis virus expressing A33VACV, is sufficient to protect mice against lethal challenge with vaccinia virus WR (VACV-WR) and ectromelia virus (ECTV) but not against cowpox virus (CPXV), a closely related orthopoxvirus. Moreover, a subunit vaccine based on the cowpox virus A33 ortholog (A33CPXV) failed to protect against cowpox and only partially protected mice against VACV-WR challenge. We mapped regions of sequence variation between A33VACV and A33CPXVand analyzed the role of such variations in protection. We identified a single protective region located between residues 104-120 that harbors a putative H-2Kd T cell epitope as well as a B cell epitope - a target for the neutralizing antibody MAb-1G10 that blocks spreading of extracellular virions. Both epitopes in A33CPXV are mutated and predicted to be non-functional. Whereas vaccination with A33VACV did not induce in-vivo CTL activity to the predicted epitope, inhibition of virus spread in-vitro, and protection from lethal VACV challenge pointed to the B cell epitope highlighting the critical role of residue L118 and of adjacent compensatory residues in protection. This epitope's critical role in protection, as well as its modifications within the orthopoxvirus genus should be taken in context with the failure of A33 to protect against CPXV as demonstrated here. These findings should be considered when developing new subunit vaccines and monoclonal antibody based therapeutics against orthopoxviruses, especially variola virus, the etiologic agent of smallpox.

The importance of protected areas for the forest and endemic avifauna of Sulawesi (Indonesia).

PubMed

Lee, Tien Ming; Sodhi, Navjot S; Prawiradilaga, Dewi M

2007-09-01

Protected areas are critical for the conservation of residual tropical forest biodiversity, yet many of these are being deforested by humans both within and outside of their administrative boundaries. Therefore, it is critical to document the significance of protected areas for conserving tropical biodiversity, particularly in mega-diverse Southeast Asia. We evaluated the importance of protected areas (national parks [NP], nature reserves [NR], and wildlife reserves [WR]) in preserving avifaunal diversity, particularly the endemic and forest species, on the island of Sulawesi. This island has one of the highest numbers of endemic avifauna genera (12) globally and is also experiencing heavy deforestation. Rarefaction analyses and species estimators showed that parks and reserves consistently recorded higher number of forest, endemic, and endemic forest bird species, in addition to larger population densities, than in their surrounding human-modified areas across eight protected areas (Gunung Manembo-nembo WR, Tangkoko-Batu Angus and Dua Saudara NR, Gunung Ambang NR, Bogani Nani Wartabone NP, Gunung Tinombala NR, Gunung Sojol NR, Lore Lindu NP, and Rawa Aopa Watumohai NP). This implies that protecting natural forests must remain as one of the fundamental conservation strategies in Sulawesi. Two small reserves (Gunung Manembo-nembo WR and Tangkoko-Batu Angus and Dua Saudara NR), however, had high number of forest and endemic bird species both within and outside their boundaries, suggesting the importance of buffer areas for augmenting small reserves so as to improve their conservation value. Ordination analyses revealed the differential response of bird species to different environmental factors (e.g., native tree cover), highlighting the significance of forested habitats with dense native vegetation cover for effective conservation of forest dependent and endemic avifauna. In addition, the distinctiveness in bird species composition among protected areas highlights the importance of establishing a reserve network across major altitudinal zones so as to achieve maximum complementarity for the conservation of Sulawesi's unique avifauna.

Attenuated and Replication-Competent Vaccinia Virus Strains M65 and M101 with Distinct Biology and Immunogenicity as Potential Vaccine Candidates against Pathogens

PubMed Central

Sánchez-Sampedro, Lucas; Gómez, Carmen Elena; Mejías-Pérez, Ernesto; Pérez-Jiménez, Eva; Oliveros, Juan Carlos

2013-01-01

Replication-competent poxvirus vectors with an attenuation phenotype and with a high immunogenic capacity of the foreign expressed antigen are being pursued as novel vaccine vectors against different pathogens. In this investigation, we have examined the replication and immunogenic characteristics of two vaccinia virus (VACV) mutants, M65 and M101. These mutants were generated after 65 and 101 serial passages of persistently infected Friend erythroleukemia (FEL) cells. In cultured cells of different origins, the mutants are replication competent and have growth kinetics similar to or slightly reduced in comparison with those of the parental Western Reserve (WR) virus strain. In normal and immune-suppressed infected mice, the mutants showed different levels of attenuation and pathogenicity in comparison with WR and modified vaccinia Ankara (MVA) strains. Wide genome analysis after deep sequencing revealed selected genomic deletions and mutations in a number of viral open reading frames (ORFs). Mice immunized in a DNA prime/mutant boost regimen with viral vectors expressing the LACK (Leishmania homologue for receptors of activated C kinase) antigen of Leishmania infantum showed protection or a delay in the onset of cutaneous leishmaniasis. Protection was similar to that triggered by MVA-LACK. In immunized mice, both polyfunctional CD4+ and CD8+ T cells with an effector memory phenotype were activated by the two mutants, but the DNA-LACK/M65-LACK protocol preferentially induced CD4+ whereas DNA-LACK/M101-LACK preferentially induced CD8+ T cell responses. Altogether, our findings showed the adaptive changes of the WR genome during long-term virus-host cell interaction and how the replication competency of M65 and M101 mutants confers distinct biological properties and immunogenicity in mice compared to those of the MVA strain. These mutants could have applicability for understanding VACV biology and as potential vaccine vectors against pathogens and tumors. PMID:23596295

Active vaccination with vaccinia virus A33 protects mice against lethal vaccinia and ectromelia viruses but not against cowpoxvirus; elucidation of the specific adaptive immune response

PubMed Central

2013-01-01

Vaccinia virus protein A33 (A33VACV) plays an important role in protection against orthopoxviruses, and hence is included in experimental multi-subunit smallpox vaccines. In this study we show that single-dose vaccination with recombinant Sindbis virus expressing A33VACV, is sufficient to protect mice against lethal challenge with vaccinia virus WR (VACV-WR) and ectromelia virus (ECTV) but not against cowpox virus (CPXV), a closely related orthopoxvirus. Moreover, a subunit vaccine based on the cowpox virus A33 ortholog (A33CPXV) failed to protect against cowpox and only partially protected mice against VACV-WR challenge. We mapped regions of sequence variation between A33VACV and A33CPXVand analyzed the role of such variations in protection. We identified a single protective region located between residues 104–120 that harbors a putative H-2Kd T cell epitope as well as a B cell epitope - a target for the neutralizing antibody MAb-1G10 that blocks spreading of extracellular virions. Both epitopes in A33CPXV are mutated and predicted to be non-functional. Whereas vaccination with A33VACV did not induce in-vivo CTL activity to the predicted epitope, inhibition of virus spread in-vitro, and protection from lethal VACV challenge pointed to the B cell epitope highlighting the critical role of residue L118 and of adjacent compensatory residues in protection. This epitope’s critical role in protection, as well as its modifications within the orthopoxvirus genus should be taken in context with the failure of A33 to protect against CPXV as demonstrated here. These findings should be considered when developing new subunit vaccines and monoclonal antibody based therapeutics against orthopoxviruses, especially variola virus, the etiologic agent of smallpox. PMID:23842430

Luminous blue variables and the fates of very massive stars

NASA Astrophysics Data System (ADS)

Smith, Nathan

2017-09-01

Luminous blue variables (LBVs) had long been considered massive stars in transition to the Wolf-Rayet (WR) phase, so their identification as progenitors of some peculiar supernovae (SNe) was surprising. More recently, environment statistics of LBVs show that most of them cannot be in transition to the WR phase after all, because LBVs are more isolated than allowed in this scenario. Additionally, the high-mass H shells around luminous SNe IIn require that some very massive stars above 40 M⊙ die without shedding their H envelopes, and the precursor outbursts are a challenge for understanding the final burning sequences leading to core collapse. Recent evidence suggests a clear continuum in pre-SN mass loss from super-luminous SNe IIn, to regular SNe IIn, to SNe II-L and II-P, whereas most stripped-envelope SNe seem to arise from a separate channel of lower-mass binary stars rather than massive WR stars. This article is part of the themed issue 'Bridging the gap: from massive stars to supernovae'.

DISCOVERY OF A WOLF-RAYET STAR THROUGH DETECTION OF ITS PHOTOMETRIC VARIABILITY

DOE Office of Scientific and Technical Information (OSTI.GOV)

Littlefield, Colin; Garnavich, Peter; McClelland, Colin

We report the serendipitous discovery of a heavily reddened Wolf-Rayet star that we name WR 142b. While photometrically monitoring a cataclysmic variable, we detected weak variability in a nearby field star. Low-resolution spectroscopy revealed a strong emission line at 7100 A, suggesting an unusual object and prompting further study. A spectrum taken with the Hobby-Eberly Telescope confirms strong He II emission and an N IV 7112 A line consistent with a nitrogen-rich Wolf-Rayet star of spectral class WN6. Analysis of the He II line strengths reveals no detectable hydrogen in WR 142b. A blue-sensitive spectrum obtained with the Large Binocularmore » Telescope shows no evidence for a hot companion star. The continuum shape and emission line ratios imply a reddening of E(B - V) = 2.2-2.6 mag. We estimate that the distance to WR 142b is 1.4 {+-} 0.3 kpc.« less

Anomalous cosmic ray fluxes in diffusive shock acceleration processes in the heliosphere and in planetary and WR-nebulae

NASA Astrophysics Data System (ADS)

Yeghikyan, Ararat

2018-04-01

Based on the analogy between interacting stellar winds of planetary nebulae and WR-nebulae, on the one hand, and the heliosphere and the expanding envelopes of supernovae, on the other, an attempt is made to calculate the differential intensity of the energetic protons accelerated to energies of 100 MeV by the shock wave. The proposed one-parameter formula for estimating the intensity at 1-100 MeV, when applied to the heliosphere, shows good agreement with the Voyager-1 data, to within a factor of less than 2. The same estimate for planetary (and WR-) nebulae yields a value 7-8 (3-4) orders of magnitude higher than the mean galactic intensity value. The obtained estimate of the intensity of energetic protons in mentioned kinds of nebulae was used to estimate the doses of irradiation of certain substances, in order to show that such accelerated particles play an important role in radiation-chemical transformations in such nebulae.

On the rarity of X-ray binaries with Wolf-Rayet donors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Linden, T.; Valsecchi, F.; Kalogera, V.

The paucity of High mass X-Ray binaries (HMXB) consisting of a neutron star (NS) accretor and Wolf-Rayet (WR) donor has long been at odds with expectations from population synthesis studies indicating that these systems should survive as the evolved offspring of the observed HMXB population. This tension is particularly troubling in light of recent observations uncovering a preponderance of HMXBs containing loosely bound Be donors which would be expected to naturally evolve into WR-HMXBs. Reconciling the unexpectedly large population of Be-HMXBs with the lack of observed WR-HMXB sources thus serves to isolate the dynamics of CE physics from other binarymore » evolution parameters. We find that binary mergers during CE events must be common in order to resolve tension between these observed populations. Furthermore, future observations which better constrain the background population of loosely bound O/B-NS binaries are likely to place significant constraints on the efficiency of CE removal.« less

Research on wire rope deformation distribution of WR-CVT

NASA Astrophysics Data System (ADS)

Zhang, Wu; Guo, Wei; Zhang, Chuanwei; Lu, Zhengxiong; Xu, Xiaobin

2017-07-01

A wire rope continuously variable transmissions (WR-CVT) has been introduced in the paper, in view of its less research, this paper mainly studied the deformation distribution of 6×7+IWS bending wire rope. The results shown that in the same section, half of the side strands are in a stretched state and half are in a compressed state. When the transmission ratio i=2.35, the maximum deformation and the minimum deformation are decrease when section U1 to U2, U3 transition. Wire deformation distribution when the transmission ratio i=0.42 is similar to that of i=0.2.35. Wire deformation amount and the deformation difference decrease as the transmission ratio decreases, this shows that the increase in the bending radius of the wire will make the wire deformation more uniform, and the reduction of the deformation difference will also reduce the wear. This study provides a basis for the study of fatigue and wears failure of WR-CVT components.

Comparative investigation of anticlastogenic effects in cell cultures of healthy donors and patients with nettle-rash.

PubMed

Arutyunyan, R M; Sarkisyan, T F; Oganesyan, G G; Durnev, A D

1994-03-01

In cultures of lymphocytes from 12 healthy donors and 12 patients with nettle-rash (NR) the anticlastogenic effect of the antimutagens WR-2721 (WR), bemitil (BM), tomerzol (TM) and interferon (IF) on the induction of chromosomal aberrations by photrin (PT) and dioxidine (DX) was investigated. There were no statistically significant differences between healthy donors and patients with NR in the levels of chromosomal aberrations that were spontaneous or induced by PT or DX. Statistically significant protective effects of BM, WR, TM and IF were demonstrated in cells of healthy donors after treatment with PT or DX, and after modification of the clastogenic action of PT in lymphocytes of NR patients. There was no protective effect of any of the anticlastogens after treatment of the lymphocyte cultures from NR patients with DX. That observation allows us to suggest the test of anticlastogenic action as a measure of sensitivity of the chromosomal apparatus in groups with different genetic risks.

Influence of Waveform Characteristics on LiDAR Ranging Accuracy and Precision

PubMed Central

Yang, Bingwei; Xie, Xinhao; Li, Duan

2018-01-01

Time of flight (TOF) based light detection and ranging (LiDAR) is a technology for calculating distance between start/stop signals of time of flight. In lab-built LiDAR, two ranging systems for measuring flying time between start/stop signals include time-to-digital converter (TDC) that counts time between trigger signals and analog-to-digital converter (ADC) that processes the sampled start/stop pulses waveform for time estimation. We study the influence of waveform characteristics on range accuracy and precision of two kinds of ranging system. Comparing waveform based ranging (WR) with analog discrete return system based ranging (AR), a peak detection method (WR-PK) shows the best ranging performance because of less execution time, high ranging accuracy, and stable precision. Based on a novel statistic mathematical method maximal information coefficient (MIC), WR-PK precision has a high linear relationship with the received pulse width standard deviation. Thus keeping the received pulse width of measuring a constant distance as stable as possible can improve ranging precision. PMID:29642639

ON THE LAUNCHING AND STRUCTURE OF RADIATIVELY DRIVEN WINDS IN WOLF–RAYET STARS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ro, Stephen; Matzner, Christopher D., E-mail: ro@astro.utoronto.ca

Hydrostatic models of Wolf–Rayet (WR) stars typically contain low-density outer envelopes that inflate the stellar radii by a factor of several and are capped by a denser shell of gas. Inflated envelopes and density inversions are hallmarks of envelopes that become super-Eddington as they cross the iron-group opacity peak, but these features disappear when mass loss is sufficiently rapid. We re-examine the structures of steady, spherically symmetric wind solutions that cross a sonic point at high optical depth, identifying the physical mechanism through which the outflow affects the stellar structure, and provide an improved analytical estimate for the critical mass-lossmore » rate above which extended structures are erased. Weak-flow solutions below this limit resemble hydrostatic stars even in supersonic zones; however, we infer that these fail to successfully launch optically thick winds. WR envelopes will therefore likely correspond to the strong, compact solutions. We also find that wind solutions with negligible gas pressure are stably stratified at and below the sonic point. This implies that convection is not the source of variability in WR stars, as has been suggested; however, acoustic instabilities provide an alternative explanation. Our solutions are limited to high optical depths by our neglect of Doppler enhancements to the opacity, and do not account for acoustic instabilities at high Eddington factors; yet, they do provide useful insights into WR stellar structures.« less

Side-chain hydroxylation in the metabolism of 8-aminoquinoline antiparasitic agents.

PubMed

Idowu, O R; Peggins, J O; Brewer, T G

1995-01-01

Primaquine, 8-(4-amino-1-methylbutylamino)-6-methoxyquinoline, is an antimalarial 8-aminoquinoline derivative. Although it has been in use since 1952, its metabolism has not been clearly defined. This is due to the instability of the expected aminophenol metabolites and their amphoteric nature, which makes their isolation difficult. Recent studies on the metabolism of WR 238605, a new primaquine analog, has shown that these problems may be solved by extracting the metabolites in the presence of ethyl chloroformate. Subsequent identification of the ethoxycarbonyl derivatives of the metabolites has made it possible to define the in vitro metabolism of primaquine. The primary metabolic pathways of primaquine involved hydroxylation of the phenyl ring of the quinoline nucleus and C-hydroxylation of the 3'-position of the 8-aminoalkylamino side chain. Ring-hydroxylation of primaquine gives rise to 5-hydroxyprimaquine, which on demethylation produces 5-hydroxy-6-demethylprimaquine. Side-chain hydroxylation of primaquine gives rise to 3'-hydroxyprimaquine, which also undergoes O-demethylation to 3'-hydroxy-6-demethylprimaquine. 6-Demethylprimaquine, a putative metabolite of primaquine, also underwent metabolism involving 3'-hydroxylation of the side chain. WR 6026, 8-(6-diethylaminohexylamino)-6-methoxy-4-methylquinoline, is an antileishmanial 8-aminoquinoline derivative. The in vitro metabolism of WR 6026 also results in the formation of side chain-oxygenated metabolites. The present results, together with previous observations on the metabolism of WR 238605 and closely related primaquine analog, suggest that side-chain oxygenation is an important metabolic pathway of antiparasitic 8-aminoquinoline compounds in general.

Reentrant Information Flow in Electrophysiological Rat Default Mode Network.

PubMed

Jing, Wei; Guo, Daqing; Zhang, Yunxiang; Guo, Fengru; Valdés-Sosa, Pedro A; Xia, Yang; Yao, Dezhong

2017-01-01

Functional MRI (fMRI) studies have demonstrated that the rodent brain shows a default mode network (DMN) activity similar to that in humans, offering a potential preclinical model both for physiological and pathophysiological studies. However, the neuronal mechanism underlying rodent DMN remains poorly understood. Here, we used electrophysiological data to analyze the power spectrum and estimate the directed phase transfer entropy (dPTE) within rat DMN across three vigilance states: wakeful rest (WR), slow-wave sleep (SWS), and rapid-eye-movement sleep (REMS). We observed decreased gamma powers during SWS compared with WR in most of the DMN regions. Increased gamma powers were found in prelimbic cortex, cingulate cortex, and hippocampus during REMS compared with WR, whereas retrosplenial cortex showed a reverse trend. These changed gamma powers are in line with the local metabolic variation of homologous brain regions in humans. In the analysis of directional interactions, we observed well-organized anterior-to-posterior patterns of information flow in the delta band, while opposite patterns of posterior-to-anterior flow were found in the theta band. These frequency-specific opposite patterns were only observed in WR and REMS. Additionally, most of the information senders in the delta band were also the receivers in the theta band, and vice versa. Our results provide electrophysiological evidence that rat DMN is similar to its human counterpart, and there is a frequency-dependent reentry loop of anterior-posterior information flow within rat DMN, which may offer a mechanism for functional integration, supporting conscious awareness.

Using MOST to reveal the secrets of the mischievous Wolf-Rayet binary CV Ser

NASA Astrophysics Data System (ADS)

David-Uraz, Alexandre; Moffat, Anthony F. J.; Chené, André-Nicolas; Rowe, Jason F.; Lange, Nicholas; Guenther, David B.; Kuschnig, Rainer; Matthews, Jaymie M.; Rucinski, Slavek M.; Sasselov, Dimitar; Weiss, Werner W.

2012-11-01

The Wolf-Rayet (WR) binary CV Serpentis (= WR113, WC8d + O8-9IV) has been a source of mystery since it was shown that its atmospheric eclipses change with time over decades, in addition to its sporadic dust production. The first high-precision time-dependent photometric observations obtained with the Microvariability and Oscillations of STars (MOST) space telescope in 2009 show two consecutive eclipses over the 29-d orbit, with varying depths. A subsequent MOST run in 2010 showed a seemingly asymmetric eclipse profile. In order to help make sense of these observations, parallel optical spectroscopy was obtained from the Mont Megantic Observatory (2009, 2010) and from the Dominion Astrophysical Observatory (2009). Assuming these depth variations are entirely due to electron scattering in a β-law wind, an unprecedented 62 per cent increase in M⊙ is observed over one orbital period. Alternatively, no change in mass-loss rate would be required if a relatively small fraction of the carbon ions in the wind globally recombined and coaggulated to form carbon dust grains. However, it remains a mystery as to how this could occur. There also seems to be evidence for the presence of corotating interaction regions (CIR) in the WR wind: a CIR-like signature is found in the light curves, implying a potential rotation period for the WR star of 1.6 d. Finally, a new circular orbit is derived, along with constraints for the wind collision.

Remarkable long-term changes in the small Magellanic Cloud Wolf-Rayet system HD 5980

NASA Technical Reports Server (NTRS)

Koenigsberger, G.; Moffat, A. F. J.; St-Louis, N.; Auer, L. H.; Drissen, L.; Seggewiss, W.

1994-01-01

In this paper we report the remarkable changes which occured in the Small Magellanic Cloud W-R system HD5980 = AB5 between 1978 and 1991. Within this timescale, there has been a systematic enhancement (by factors of 2-10 depending on the line) in the equivalent widths of all emission lines, and a change in the relative strengths of N III, N IV, and N V lines. Currently, the W-R spectrum is more typical of a WN6 star than a WN3 or WN4, as it was originally classified. The terminal speed of the wind has diminished by approximately 600 km/s, while the system has brightened in the visual by 0.45 mag. The UV (1850 A) continuum changed by less than 0.13 mag. The change from WN3 or WN4 to WN6 is unprecedented. The system appears to be composed at least three stars: two WNs in mutual 19.266 day orbit and an O-type supergiant. We propose that the changes observed in HD 5980 are related to an increase in wind density of one (or both?) of the W-R components, where the brighter WN6 component will dominate the W-R spectrum after the change, and we speculate that this modification of the wind structure is driven by tidal interaction induced by a possible current periastron passage of the third component in the system.

Dosimetric and Clinical Outcomes With Intensity Modulated Radiation Therapy After Chemotherapy for Patients With Early-Stage Diffuse Large B-cell Lymphoma of Waldeyer Ring

DOE Office of Scientific and Technical Information (OSTI.GOV)

Xu, Yong-Gang; Qi, Shu-Nan; Wang, Shu-Lian

Purpose: To assess the dosimetric benefit, prognosis, and toxicity of intensity modulated radiation therapy (IMRT) for early-stage, diffuse large B-cell lymphoma of Waldeyer ring (WR-DLBCL). Methods and Materials: Sixty-one patients with early-stage WR-DLBCL who received chemotherapy followed by IMRT were retrospectively reviewed. Dosimetric parameters for the target volume and critical normal structures were evaluated, and survival was calculated. Linear regression analysis was used to assess the effect of the mean dose (D{sub mean}) to the parotid glands on xerostomia. Results: The median conformity index and homogeneity index of the planning target volume (PTV) were 0.83 and 0.90, respectively, demonstrating verymore » good coverage of the target volume. The mean dose to the parotid glands was 24.9 Gy. The 5-year overall survival (OS), progression-free survival (PFS), and locoregional control (LRC) were 94.7%, 93.1%, and 98.3%, respectively. Early and late toxicities were mild, and no patient experienced late grade ≥3 toxicities. The D{sub mean} to the parotid glands had a linear correlation with late grade ≥2 xerostomia. Conclusions: IMRT after chemotherapy can provide excellent dose conformity and achieve favorable survival and LRC with mild toxicities in patients with early-stage WR-DLBCL. Dose constraints for the parotid glands should be limited to <24 Gy for early-stage WR-DLBCL.« less

N-(3-Benzoylphenyl)-1H-Indole-2-Carboxamide decreases triglyceride levels by downregulation of Apoc3 gene expression in acute hyperlipidemic rat model.

PubMed

Hamadneh, Lama; Al-Essa, Luay; Hikmat, Suhair; Al-Qirim, Tariq; Abu Sheikha, Ghassan; Al-Hiari, Yusuf; Azmy, Nisrin; Shattat, Ghassan

2017-07-01

Hyperlipidemia is a known cause of coronary vascular diseases, which is a major cause of death in many parts of the world. Targeting several pathways that lead to increase in lipid profiles is of great potential to control diseases. 1H-indole-2-carboxamide derivatives were tested for their hypolipidemic activity at the molecular level in comparison with bezafibrate. The gene expression profiles of lipoprotein signaling and cholesterol metabolism and fatty acid metabolism PCR arrays were determined in rats with acute hyperlipidemia induced by Triton WR1339. Lipid profiles of serum from treated rats showed significant hypolipidemic effect by the compounds. Several genes of potential interest were reported to be overexpressed by Triton WR1339 including Apoc3, Apob, Hmgcs2, Apoa1, Apoe, Apof, acsl1, and Decr1. Most of the overexpressed genes were downregulated by N-(3-Benzoylphenyl)-1H-Indole-2-Carboxamide with significant decreases in Apoc3, Apob, Acaa2, Acsl1, and Slc247a5 gene expression levels. N-(4-Benzoylphenyl)-1H-Indole-2-Carboxamide and bezafibrate did not significantly affect the gene expression levels which were increased with acute hyperlipidemia induced by Triton WR1339. In conclusion, gene expression profiling identified the possible mechanism in which Triton WR1339 induces its acute hyperlipidemic effect which was reversed by the use of N-(3-Benzoylphenyl)-1H-Indole-2-Carboxamide.

Apatite (U-Th)/He thermochronometry as an innovative geothermal exploration tool: A case study from the southern Wassuk Range, Nevada

NASA Astrophysics Data System (ADS)

Gorynski, Kyle E.; Walker, J. Douglas; Stockli, Daniel F.; Sabin, Andrew

2014-01-01

Extensional-type geothermal systems are complicated by the interrelation between footwall advection during exhumation, and the subsequent redistribution of heat by migrating hydrothermal fluids in the hanging wall. The southern Wassuk Range (WR) hanging wall hosts a moderate-temperature, extensional-type geothermal system and is ideal for studying this duality by analyzing a suite of apatite (AHe) and zircon (ZHe) helium samples from the footwall and hanging wall of the southern WR. Young (~ 3-4 Ma) AHe ages along the WR front are concentrated along the SE corners of segmented footwall blocks, marking the location of focused Mio-Pliocene transtension, fracture dilation, and advection. Hydrothermally reset AHe ages along the footwall range front suggest that the Hawthorne geothermal system (85°-135° C) is long lived and has resided at a prominent structural boundary in the WR footwall marked by localized advection and range-front deformation. In contrast, the presence of both hydrothermally reset and non-reset AHe ages from a ~ 1.4 km deep borehole in the hanging-wall basin probably indicate that the geothermal plumbing system and current manifestation as a thermal anomaly (~ 113 °C) are juvenile and are controlled by the generation of newly formed faults in the hanging wall. AHe ages have been shown here to greatly enhance the focusing of regional-scale geothermal exploration efforts, and for the first time have been used to identify and estimate the temperature of unseen hydrothermal fluids.

The slow component of O(2) uptake is not accompanied by changes in muscle EMG during repeated bouts of heavy exercise in humans.

PubMed

Scheuermann, B W; Hoelting, B D; Noble, M L; Barstow, T J

2001-02-15

1. We hypothesized that either the recruitment of additional muscle motor units and/or the progressive recruitment of less efficient fast-twitch muscle fibres was the predominant contributor to the additional oxygen uptake (VO2) observed during heavy exercise. Using surface electromyographic (EMG) techniques, we compared the VO2 response with the integrated EMG (iEMG) and mean power frequency (MPF) response of the vastus lateralis with the VO2 response during repeated bouts of moderate (below the lactate threshold, < LT) and heavy (above the lactate threshold, > LT) intensity cycle ergometer exercise. 2. Seven male subjects (age 29 +/- 7 years, mean +/- S.D.) performed three transitions to a work rate (WR) corresponding to 90 % LT and two transitions to a work rate that would elicit a VO2 corresponding to 50 % of the difference between peak VO2 and the LT (i.e. Delta50 %, > LT1 and > LT2). 3. The VO2 slow component was significantly reduced by prior heavy intensity exercise (> LT1, 410 +/- 196 ml min(-1); > LT2, 230 +/- 191 ml min-1). The time constant (tau), amplitude (A) and gain (DeltaVO2/DeltaWR) of the primary VO2 response (phase II) were not affected by prior heavy exercise when a three-component, exponential model was used to describe the V2 response. 4. Integrated EMG and MPF remained relatively constant and at the same level throughout both > LT1 and > LT2 exercise and therefore were not associated with the VO2 slow component. 5. These data are consistent with the view that the increased O2 cost (i.e. VO2 slow component) associated with performing heavy exercise is coupled with a progressive increase in ATP requirements of the already recruited motor units rather than to changes in the recruitment pattern of slow versus fast-twitch motor units. Further, the lack of speeding of the kinetics of the primary VO2 component with prior heavy exercise, thought to represent the initial muscle VO2 response, are inconsistent with O2 delivery being the limiting factor in V > O2 kinetics during heavy exercise.

A Metronidazole-Resistant Isolate of Blastocystis spp. Is Susceptible to Nitric Oxide and Downregulates Intestinal Epithelial Inducible Nitric Oxide Synthase by a Novel Parasite Survival Mechanism ▿

PubMed Central

Mirza, Haris; Wu, Zhaona; Kidwai, Fahad; Tan, Kevin S. W.

2011-01-01

Blastocystis, one of the most common parasites colonizing the human intestine, is an extracellular, noninvasive, luminal protozoan with controversial pathogenesis. Blastocystis infections can be asymptomatic or cause intestinal symptoms of vomiting, diarrhea, and abdominal pain. Although chronic infections are frequently reported, Blastocystis infections have also been reported to be self-limiting in immunocompetent patients. Characterizing the host innate response to Blastocystis would lead to a better understanding of the parasite's pathogenesis. Intestinal epithelial cells produce nitric oxide (NO), primarily on the apical side, in order to target luminal pathogens. In this study, we show that NO production by intestinal cells may be a host defense mechanism against Blastocystis. Two clinically relevant isolates of Blastocystis, ST-7 (B) and ST-4 (WR-1), were found to be susceptible to a range of NO donors. ST-7 (B), a metronidazole-resistant isolate, was found to be more sensitive to nitrosative stress. Using the Caco-2 model of human intestinal epithelium, Blastocystis ST-7 (B) but not ST-4 (WR-1) exhibited dose-dependent inhibition of Caco-2 NO production, and this was associated with downregulation of inducible nitric oxide synthase (iNOS). Despite its higher susceptibility to NO, Blastocystis ST-7 (B) may have evolved unique strategies to evade this potential host defense by depressing host NO production. This is the first study to highlight a strain-to-strain variation in the ability of Blastocystis to evade the host antiparasitic NO response. PMID:21930763

The Evolution and Physical Parameters of WN3/O3s: A New Type of Wolf-Rayet Star

NASA Astrophysics Data System (ADS)

Neugent, Kathryn F.; Massey, Philip; Hillier, D. John; Morrell, Nidia

2017-05-01

As part of a search for Wolf-Rayet (WR) stars in the Magellanic Clouds, we have discovered a new type of WR star in the Large Magellanic Cloud (LMC). These stars have both strong emission lines, as well as He II and Balmer absorption lines and spectroscopically resemble a WN3 and O3V binary pair. However, they are visually too faint to be WN3+O3V binary systems. We have found nine of these WN3/O3s, making up ˜6% of the population of LMC WRs. Using cmfgen, we have successfully modeled their spectra as single stars and have compared the physical parameters with those of more typical LMC WNs. Their temperatures are around 100,000 K, a bit hotter than the majority of WN stars (by around 10,000 K), though a few hotter WNs are known. The abundances are what you would expect for CNO equilibrium. However, most anomalous are their mass-loss rates, which are more like that of an O-type star than a WN star. While their evolutionary status is uncertain, their low mass-loss rates and wind velocities suggest that they are not products of homogeneous evolution. It is possible instead that these stars represent an intermediate stage between O stars and WNs. Since WN3/O3 stars are unknown in the Milky Way, we suspect that their formation depends upon metallicity, and we are investigating this further by a deep survey in M33, which possesses a metallicity gradient. This paper includes data gathered with the 6.5 m Magellan Telescopes located at Las Campanas Observatory, Chile. It is additionally based on observations made with the NASA/ESA Hubble Space Telescope, obtained at the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS 5-26555. These observations were associated with program GO-13780.

Luminous clusters of Wolf-Rayet stars in the SBmIII galaxy NGC 4214

NASA Technical Reports Server (NTRS)

Sargent, Wallace L. W.; Filippenko, Alexei V.

1991-01-01

Observations are reported of strong broad emission lines attributed to WR stars in the spectra of several bright knots in the nearby Magellanic irregular galaxy NGC 4214 (classified as type SBmIII), in addition to the emission produced by the more prevalent WN stars). Data are presented on measurements of the line fluxes, the line equivalent widths, and continuum flux densities in the four observed knots, showing that the strongest WR lines generally appear in knots having the most luminous stellar continuum. The significance of this observation is discussed.

MEMS PolyMUMPS-Based Miniature Microphone for Directional Sound Sensing

DTIC Science & Technology

2007-09-01

of the translating mode Phir=-atan((2*wr*er*w)/(wr^2-w^2));% Phase constant rocking Phit =-atan((2*wt*et*w)/(wt^2-w^2));% Phase constant translating...2.5e-6)+1 Yl(count)=8e6*(At*sin(w.*t(count)+ Phit ) + Ar*cos(w.*t(count)+Phir)); %left membrane displacement as a function of time in micrometers...Xl(count)=-(((.5)^2-Yl(count).^2).^.5); Yr(count)=8e6*(At*sin(w.*t(count)+ Phit ) - Ar*cos(w.*t(count)+Phir)); %right membrane displacement

The Automated Aircraft Rework System (AARS): A system integration approach

NASA Technical Reports Server (NTRS)

Benoit, Michael J.

1994-01-01

The Mercer Engineering Research Center (MERC), under contract to the United States Air Force (USAF) since 1989, has been actively involved in providing the Warner Robins Air Logistics Center (WR-ALC) with a robotic workcell designed to perform rework automated defastening and hole location/transfer operations on F-15 wings. This paper describes the activities required to develop and implement this workcell, known as the Automated Aircraft Rework System (AARS). AARS is scheduled to be completely installed and in operation at WR-ALC by September 1994.

High-Power Copper Gratings for a Sheet-Beam Traveling-Wave Amplifier at G-Band

DTIC Science & Technology

2013-01-01

respectively). A. Two-Port CTF The CTF was CNC machined from OFHC copper. The gratings were tightly clamped into place in the fixture. The results of the... CNC machined such that only ten slots were exposed, followed by a short for the rest of the grating. Adaptors to standard WR5 and WR10 waveguides were...of low-voltage grating Cerenkov amplifiers,” Phys. Plasmas , vol. 1, no. 1, pp. 176–188, Jan. 1994. [11] C. D. Joye, J. P. Calame, K. T. Nguyen, and M

Magnetic rotational hysteresis study on spherical 85-160 nm Fe3O4 particles

NASA Astrophysics Data System (ADS)

Schmidbauer, E.

1988-05-01

Rotational hysteresis losses Wr were determined as a function of magnetic field H for dispensed spherical Fe3O4 particles of mean grain sizes 85 nm, 127 nm and 162 nm between 78 K and 294 K. The observed Wr-H curves are compared with theoretical curves for single domain particles. The analysed particles reveal centers of high magnetic anisotropy. Such centers can be of importance during the generation of a thermoremanent magnetization, as they may be the origin of enhanced magnetic stability.

Comparative Study of Antimalarial and Other Drugs on G6PD Deficient Red Cells.

DTIC Science & Technology

33063 (1600 mg x day for 6 days) and WR 30090 (690 mg x day for 3- 6 days) demonstrated that these drugs were not hemolytic for G6PD deficient red cells...The studies concerning the effects of DFD on G6PD deficient red cells of the A- and B- variants were completed during the course of this contract...DFD is especially hemolytic even at low single dosages for G6PD deficient red cells of the B- type. The investigations on the new antimalarials WR

Four Week Oral Toxicity Study of WR242511 in Dogs. Volume 2

DTIC Science & Technology

1994-06-03

10^6/cmm Erythrocytes 0.00 NO 6.00 6.00 8.00 8.00 2. HGB g/dL Hemoglobin 0.0 NO 12.0 12.0 19.0 19.0 3. HCT % Hematocrit 0.0 NO 35.0 35.0...IS/ UU CAJ U INDIVIDUAL ANIMAL HEMATOLOGY REPORT BY GROUP TEST : Erythrocytes STUDY ID: 134 SEX: MALE STUDY NO: 134 • ABBR...FOUR WEEK ORAL TOXICITY STUDY OF WR242511 IN DOGS DRAFT INDIVIDUAL ANIMAL HEMATOLOGY REPORT BY GROUP TEST: Erythrocytes STUDY ID: 134 STUDY NO

Drug inhibition of first-stage radioemesis. Interim report, 5 November 1975--31 December 1976

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gralla, E.J.; Krupp, J.H.; Mattsson, J.L.

1977-06-01

An animal model of irradiation-induced emesis was developed which involved exposing young male beagle dogs to 800 rads in the abdominal area. This caused a 100% incidence of emesis within 8 hr and a second wave of emesis and hemorrhagic diarrhea approximately 48 hr later. Seven drugs and one combination of two drugs were examined for effects against these responses. Chlorpromazine proved to be the most potent antagonist of first-stage emesis while dimenhydrinate and diphenhydramine HC1 showed the same activity but to a lesser degree. Inactive drugs were phenytoin sodium, perphenazine (at a low dose), WR2721, and the combination ofmore » amphetamine plus scopolamine. Acetylsalicylic acid intensified the emetic responses. (Author)« less

Split-Block Waveguide Polarization Twist for 220 to 325 GHz

NASA Technical Reports Server (NTRS)

Ward, John; Chattopadhyay, Goutam

2008-01-01

A split-block waveguide circuit that rotates polarization by 90 has been designed with WR-3 input and output waveguides, which are rectangular waveguides used for a nominal frequency range of 220 to 325 GHz. Heretofore, twisted rectangular waveguides equipped with flanges at the input and output have been the standard means of rotating the polarizations of guided microwave signals. However, the fabrication and assembly of such components become difficult at high frequency due to decreasing wavelength, such that twisted rectangular waveguides become impractical at frequencies above a few hundred gigahertz. Conventional twisted rectangular waveguides are also not amenable to integration into highly miniaturized subassemblies of advanced millimeter- and submillimeter-wave detector arrays now undergoing development. In contrast, the present polarization- rotating waveguide can readily be incorporated into complex integrated waveguide circuits such as miniaturized detector arrays fabricated by either conventional end milling of metal blocks or by deep reactive ion etching of silicon blocks. Moreover, the present split-block design can be scaled up in frequency to at least 5 THz. The main step in fabricating a splitblock polarization-rotating waveguide of the present design is to cut channels having special asymmetrically shaped steps into mating upper and lower blocks (see Figure 1). The dimensions of the steps are chosen to be consistent with the WR-3 waveguide cross section, which is 0.864 by 0.432 mm. The channels are characterized by varying widths with constant depths of 0.432, 0.324, and 0.216 mm and by relatively large corner radii to facilitate fabrication. The steps effect both a geometric transition and the corresponding impedance-matched electromagnetic-polarization transition between (1) a WR-3 rectangular waveguide oriented with the electric field vector normal to the block mating surfaces and (2) a corresponding WR-3 waveguide oriented with its electric field vector parallel to the mating surfaces of the blocks. A prototype has been built and tested. Figure 2 presents test results indicative of good performance over nearly the entire WR-3 waveguide frequency band.

Effect of replacing calcium salts of palm oil distillate with rapeseed oil, milled or whole rapeseeds on milk fatty-acid composition in cows fed maize silage-based diets.

PubMed

Givens, D I; Kliem, K E; Humphries, D J; Shingfield, K J; Morgan, R

2009-07-01

Inclusion of rapeseed feeds in dairy cow diets has the potential to reduce milk fat saturated fatty acid (SFA) and increase cis-monounsaturated fatty acid (cis-MUFA) content, but effectiveness may depend on the form in which the rapeseed is presented. Four mid-lactation Holstein dairy cows were allocated to four maize silage-based dietary treatments according to a 4 × 4 Latin Square design, with 28-day experimental periods. Treatments consisted of a control diet (C) containing 49 g/kg dry matter (DM) of calcium salts of palm oil distillate (CPO), or 49 g/kg DM of oil supplied as whole rapeseeds (WR), rapeseeds milled with wheat (MR) or rapeseed oil (RO). Replacing CPO with rapeseed feeds had no effect (P > 0.05) on milk fat and protein content, while milk yields were higher (P < 0.05) for RO and MR compared with WR (37.1, 38.1 and 34.3 kg/day, respectively). Substituting CPO with RO or MR reduced (P < 0.05) milk fat total SFA content (69.6, 55.6, 71.7 and 61.5 g/100 g fatty acids for C, RO, WR and MR, respectively) and enhanced (P < 0.05) milk cis-9 18:1 MUFA concentrations (corresponding values 18.6, 24.3, 17.0 and 23.0 g/100 g fatty acids) compared with C and WR. Treatments RO and MR also increased (P < 0.05) milk trans-MUFA content (4.4, 6.8, 10.5 g/100 g fatty acids, C, MR and RO, respectively). A lack of significant changes in milk fat composition when replacing CPO with WR suggests limited bioavailability of fatty acids in intact rapeseeds. In conclusion, replacing a commercial palm oil-based fat supplement in the diet with milled rapeseeds or rapeseed oil represented an effective strategy to alter milk fatty acid composition with the potential to improve human health. Inclusion of processed rapeseeds offered a good compromise for reducing milk SFA and increasing cis-MUFA, whilst minimising milk trans-MUFA and negative effects on animal performance.

Nitrous oxide emission from cropland and adjacent riparian buffers in contrasting hydrogeomorphic settings.

PubMed

Fisher, K; Jacinthe, P A; Vidon, P; Liu, X; Baker, M E

2014-01-01

Riparian buffers are important nitrate (NO) sinks in agricultural watersheds, but limited information is available regarding the intensity and control of nitrous oxide (NO) emission from these buffers. This study monitored (December 2009-May 2011) NO fluxes at two agricultural riparian buffers in the White River watershed in Indiana to assess the impact of land use and hydrogeomorphologic (HGM) attributes on emission. The study sites included a riparian forest in a glacial outwash/alluvium setting (White River [WR]) and a grassed riparian buffer in tile-drained till plains (Leary Weber Ditch [LWD]). Adjacent corn ( L.) fields were monitored for land use assessment. Analysis of variance identified season, land use (riparian buffer vs. crop field), and site geomorphology as major drivers of NO fluxes. Strong relationships between N mineralization and NO fluxes were found at both sites, but relationships with other nutrient cycling indicators (C/N ratio, dissolved organic C, microbial biomass C) were detected only at LWD. Nitrous oxide emission showed strong seasonal variability; the largest NO peaks occurred in late spring/early summer as a result of flooding at the WR riparian buffer (up to 27.8 mg NO-N m d) and N fertilizer application to crop fields. Annual NO emission (kg NO-N ha) was higher in the crop fields (WR: 7.82; LWD: 6.37) than in the riparian areas. A significant difference ( < 0.02) in annual NO emission between the riparian buffers was detected (4.32 vs. 1.03 kg NO-N ha at WR and LWD, respectively), and this difference was attributed to site geomorphology and flooding (WR is flood prone; no flooding occurred at tile-drained LWD). The study results demonstrate the significance of landscape geomorphology and land-stream connection (i.e., flood potential) as drivers of NO emission in riparian buffers and therefore argue that an HGM-based approach should be especially suitable for determination of regional NO budget in riparian ecosystems. Copyright © by the American Society of Agronomy, Crop Science Society of America, and Soil Science Society of America, Inc.

Radioprotection by Biological Response Modifiers Alone and in Combination with WR-2721

DTIC Science & Technology

1989-01-01

reasons related to cancer therapy rather 247 CH2 OH CH 2OH CH 2 0H H H H OH H OH H OH H OH FI(; . Chemical structure of glucan . a polgl~can consisting...2. GLUCAN : BACKGROUND AND GENERAL IMMUNOLOGIC AND HEMOPOIETIC EFFECTS Glucan (Fig. 1) is a beta -l,3-polyglucose isolated from the inner cell wall of...Adju’an, Therapy. pp. 183- 194. CH iiGOS. M. A led ) Ra%.en Press. New York Ciop. J. K. and AtSTiN. K. F 11985) A beta - glucan inhibitable receptor on human

Search for heavy neutrinos or third-generation leptoquarks in final states with two hadronically decaying τ leptons and two jets in proton-proton collisions at √{s}=13 TeV

NASA Astrophysics Data System (ADS)

Khachatryan, V.; Sirunyan, A. M.; Tumasyan, A.; Adam, W.; Asilar, E.; Bergauer, T.; Brandstetter, J.; Brondolin, E.; Dragicevic, M.; Erö, J.; Flechl, M.; Friedl, M.; Frühwirth, R.; Ghete, V. M.; Hartl, C.; Hörmann, N.; Hrubec, J.; Jeitler, M.; König, A.; Krätschmer, I.; Liko, D.; Matsushita, T.; Mikulec, I.; Rabady, D.; Rad, N.; Rahbaran, B.; Rohringer, H.; Schieck, J.; Strauss, J.; Waltenberger, W.; Wulz, C.-E.; Dvornikov, O.; Makarenko, V.; Zykunov, V.; Mossolov, V.; Shumeiko, N.; Gonzalez, J. Suarez; Alderweireldt, S.; De Wolf, E. A.; Janssen, X.; Lauwers, J.; Van De Klundert, M.; Van Haevermaet, H.; Van Mechelen, P.; Van Remortel, N.; Van Spilbeeck, A.; Zeid, S. Abu; Blekman, F.; D'Hondt, J.; Daci, N.; De Bruyn, I.; Deroover, K.; Lowette, S.; Moortgat, S.; Moreels, L.; Olbrechts, A.; Python, Q.; Tavernier, S.; Van Doninck, W.; Van Mulders, P.; Van Parijs, I.; Brun, H.; Clerbaux, B.; De Lentdecker, G.; Delannoy, H.; Fasanella, G.; Favart, L.; Goldouzian, R.; Grebenyuk, A.; Karapostoli, G.; Lenzi, T.; Léonard, A.; Luetic, J.; Maerschalk, T.; Marinov, A.; Randle-conde, A.; Seva, T.; Velde, C. Vander; Vanlaer, P.; Vannerom, D.; Yonamine, R.; Zenoni, F.; Zhang, F.; Cimmino, A.; Cornelis, T.; Dobur, D.; Fagot, A.; Garcia, G.; Gul, M.; Khvastunov, I.; Poyraz, D.; Salva, S.; Schöfbeck, R.; Sharma, A.; Tytgat, M.; Van Driessche, W.; Yazgan, E.; Zaganidis, N.; Bakhshiansohi, H.; Beluffi, C.; Bondu, O.; Brochet, S.; Bruno, G.; Caudron, A.; De Visscher, S.; Delaere, C.; Delcourt, M.; Francois, B.; Giammanco, A.; Jafari, A.; Jez, P.; Komm, M.; Krintiras, G.; Lemaitre, V.; Magitteri, A.; Mertens, A.; Musich, M.; Nuttens, C.; Piotrzkowski, K.; Quertenmont, L.; Selvaggi, M.; Marono, M. Vidal; Wertz, S.; Beliy, N.; Aldá Júnior, W. L.; Alves, F. L.; Alves, G. A.; Brito, L.; Hensel, C.; Moraes, A.; Pol, M. E.; Teles, P. Rebello; Belchior Batista Das Chagas, E.; Carvalho, W.; Chinellato, J.; Custódio, A.; Da Costa, E. M.; Da Silveira, G. G.; De Jesus Damiao, D.; De Oliveira Martins, C.; Fonseca De Souza, S.; Huertas Guativa, L. M.; Malbouisson, H.; Figueiredo, D. Matos; Herrera, C. Mora; Mundim, L.; Nogima, H.; Prado Da Silva, W. L.; Santoro, A.; Sznajder, A.; Tonelli Manganote, E. J.; Pereira, A. Vilela; Ahuja, S.; Bernardes, C. A.; Dogra, S.; Fernandez Perez Tomei, T. R.; Gregores, E. M.; Mercadante, P. G.; Moon, C. S.; Novaes, S. F.; Padula, Sandra S.; Abad, D. Romero; Ruiz Vargas, J. C.; Aleksandrov, A.; Hadjiiska, R.; Iaydjiev, P.; Rodozov, M.; Stoykova, S.; Sultanov, G.; Vutova, M.; Dimitrov, A.; Glushkov, I.; Litov, L.; Pavlov, B.; Petkov, P.; Fang, W.; Ahmad, M.; Bian, J. G.; Chen, G. M.; Chen, H. S.; Chen, M.; Chen, Y.; Cheng, T.; Jiang, C. H.; Leggat, D.; Liu, Z.; Romeo, F.; Shaheen, S. M.; Spiezia, A.; Tao, J.; Wang, C.; Wang, Z.; Zhang, H.; Zhao, J.; Ban, Y.; Chen, G.; Li, Q.; Liu, S.; Mao, Y.; Qian, S. J.; Wang, D.; Xu, Z.; Avila, C.; Cabrera, A.; Chaparro Sierra, L. F.; Florez, C.; Gomez, J. P.; González Hernández, C. F.; Ruiz Alvarez, J. D.; Sanabria, J. C.; Godinovic, N.; Lelas, D.; Puljak, I.; Ribeiro Cipriano, P. M.; Sculac, T.; Antunovic, Z.; Kovac, M.; Brigljevic, V.; Ferencek, D.; Kadija, K.; Micanovic, S.; Sudic, L.; Susa, T.; Attikis, A.; Mavromanolakis, G.; Mousa, J.; Nicolaou, C.; Ptochos, F.; Razis, P. A.; Rykaczewski, H.; Tsiakkouri, D.; Finger, M.; Finger, M.; Jarrin, E. Carrera; Assran, Y.; Elkafrawy, T.; Mahrous, A.; Kadastik, M.; Perrini, L.; Raidal, M.; Tiko, A.; Veelken, C.; Eerola, P.; Pekkanen, J.; Voutilainen, M.; Härkönen, J.; Järvinen, T.; Karimäki, V.; Kinnunen, R.; Lampén, T.; Lassila-Perini, K.; Lehti, S.; Lindén, T.; Luukka, P.; Tuominiemi, J.; Tuovinen, E.; Wendland, L.; Talvitie, J.; Tuuva, T.; Besancon, M.; Couderc, F.; Dejardin, M.; Denegri, D.; Fabbro, B.; Faure, J. L.; Favaro, C.; Ferri, F.; Ganjour, S.; Ghosh, S.; Givernaud, A.; Gras, P.; Hamel de Monchenault, G.; Jarry, P.; Kucher, I.; Locci, E.; Machet, M.; Malcles, J.; Rander, J.; Rosowsky, A.; Titov, M.; Zghiche, A.; Abdulsalam, A.; Antropov, I.; Baffioni, S.; Beaudette, F.; Busson, P.; Cadamuro, L.; Chapon, E.; Charlot, C.; Davignon, O.; Granier de Cassagnac, R.; Jo, M.; Lisniak, S.; Miné, P.; Nguyen, M.; Ochando, C.; Ortona, G.; Paganini, P.; Pigard, P.; Regnard, S.; Salerno, R.; Sirois, Y.; Strebler, T.; Yilmaz, Y.; Zabi, A.; Agram, J.-L.; Andrea, J.; Aubin, A.; Bloch, D.; Brom, J.-M.; Buttignol, M.; Chabert, E. C.; Chanon, N.; Collard, C.; Conte, E.; Coubez, X.; Fontaine, J.-C.; Gelé, D.; Goerlach, U.; Le Bihan, A.-C.; Skovpen, K.; Van Hove, P.; Gadrat, S.; Beauceron, S.; Bernet, C.; Boudoul, G.; Bouvier, E.; Carrillo Montoya, C. A.; Chierici, R.; Contardo, D.; Courbon, B.; Depasse, P.; El Mamouni, H.; Fan, J.; Fay, J.; Gascon, S.; Gouzevitch, M.; Grenier, G.; Ille, B.; Lagarde, F.; Laktineh, I. B.; Lethuillier, M.; Mirabito, L.; Pequegnot, A. L.; Perries, S.; Popov, A.; Sabes, D.; Sordini, V.; Donckt, M. Vander; Verdier, P.; Viret, S.; Toriashvili, T.; Bagaturia, I.; Autermann, C.; Beranek, S.; Feld, L.; Heister, A.; Kiesel, M. K.; Klein, K.; Lipinski, M.; Ostapchuk, A.; Preuten, M.; Raupach, F.; Schael, S.; Schomakers, C.; Schulz, J.; Verlage, T.; Weber, H.; Zhukov, V.; Albert, A.; Brodski, M.; Dietz-Laursonn, E.; Duchardt, D.; Endres, M.; Erdmann, M.; Erdweg, S.; Esch, T.; Fischer, R.; Güth, A.; Hamer, M.; Hebbeker, T.; Heidemann, C.; Hoepfner, K.; Knutzen, S.; Merschmeyer, M.; Meyer, A.; Millet, P.; Mukherjee, S.; Olschewski, M.; Padeken, K.; Pook, T.; Radziej, M.; Reithler, H.; Rieger, M.; Scheuch, F.; Sonnenschein, L.; Teyssier, D.; Thüer, S.; Cherepanov, V.; Flügge, G.; Hoehle, F.; Kargoll, B.; Kress, T.; Künsken, A.; Lingemann, J.; Müller, T.; Nehrkorn, A.; Nowack, A.; Nugent, I. M.; Pistone, C.; Pooth, O.; Stahl, A.; Martin, M. Aldaya; Arndt, T.; Asawatangtrakuldee, C.; Beernaert, K.; Behnke, O.; Behrens, U.; Bin Anuar, A. A.; Borras, K.; Campbell, A.; Connor, P.; Contreras-Campana, C.; Costanza, F.; Pardos, C. Diez; Dolinska, G.; Eckerlin, G.; Eckstein, D.; Eichhorn, T.; Eren, E.; Gallo, E.; Garcia, J. Garay; Geiser, A.; Gizhko, A.; Grados Luyando, J. M.; Gunnellini, P.; Harb, A.; Hauk, J.; Hempel, M.; Jung, H.; Kalogeropoulos, A.; Karacheban, O.; Kasemann, M.; Keaveney, J.; Kleinwort, C.; Korol, I.; Krücker, D.; Lange, W.; Lelek, A.; Leonard, J.; Lipka, K.; Lobanov, A.; Lohmann, W.; Mankel, R.; Melzer-Pellmann, I.-A.; Meyer, A. B.; Mittag, G.; Mnich, J.; Mussgiller, A.; Ntomari, E.; Pitzl, D.; Placakyte, R.; Raspereza, A.; Roland, B.; Sahin, M. Ö.; Saxena, P.; Schoerner-Sadenius, T.; Seitz, C.; Spannagel, S.; Stefaniuk, N.; Van Onsem, G. P.; Walsh, R.; Wissing, C.; Blobel, V.; Vignali, M. Centis; Draeger, A. R.; Dreyer, T.; Garutti, E.; Gonzalez, D.; Haller, J.; Hoffmann, M.; Junkes, A.; Klanner, R.; Kogler, R.; Kovalchuk, N.; Lapsien, T.; Lenz, T.; Marchesini, I.; Marconi, D.; Meyer, M.; Niedziela, M.; Nowatschin, D.; Pantaleo, F.; Peiffer, T.; Perieanu, A.; Poehlsen, J.; Sander, C.; Scharf, C.; Schleper, P.; Schmidt, A.; Schumann, S.; Schwandt, J.; Stadie, H.; Steinbrück, G.; Stober, F. M.; Stöver, M.; Tholen, H.; Troendle, D.; Usai, E.; Vanelderen, L.; Vanhoefer, A.; Vormwald, B.; Akbiyik, M.; Barth, C.; Baur, S.; Baus, C.; Berger, J.; Butz, E.; Caspart, R.; Chwalek, T.; Colombo, F.; De Boer, W.; Dierlamm, A.; Fink, S.; Freund, B.; Friese, R.; Giffels, M.; Gilbert, A.; Goldenzweig, P.; Haitz, D.; Hartmann, F.; Heindl, S. M.; Husemann, U.; Katkov, I.; Kudella, S.; Pardo, P. Lobelle; Mildner, H.; Mozer, M. U.; Müller, Th.; Plagge, M.; Quast, G.; Rabbertz, K.; Röcker, S.; Roscher, F.; Schröder, M.; Shvetsov, I.; Sieber, G.; Simonis, H. J.; Ulrich, R.; Wagner-Kuhr, J.; Wayand, S.; Weber, M.; Weiler, T.; Williamson, S.; Wöhrmann, C.; Wolf, R.; Anagnostou, G.; Daskalakis, G.; Geralis, T.; Giakoumopoulou, V. A.; Kyriakis, A.; Loukas, D.; Topsis-Giotis, I.; Kesisoglou, S.; Panagiotou, A.; Saoulidou, N.; Tziaferi, E.; Evangelou, I.; Flouris, G.; Foudas, C.; Kokkas, P.; Loukas, N.; Manthos, N.; Papadopoulos, I.; Paradas, E.; Filipovic, N.; Bencze, G.; Hajdu, C.; Horvath, D.; Sikler, F.; Veszpremi, V.; Vesztergombi, G.; Zsigmond, A. J.; Beni, N.; Czellar, S.; Karancsi, J.; Makovec, A.; Molnar, J.; Szillasi, Z.; Bartók, M.; Raics, P.; Trocsanyi, Z. L.; Ujvari, B.; Bahinipati, S.; Choudhury, S.; Mal, P.; Mandal, K.; Nayak, A.; Sahoo, D. K.; Sahoo, N.; Swain, S. K.; Bansal, S.; Beri, S. B.; Bhatnagar, V.; Chawla, R.; Bhawandeep, U.; Kalsi, A. K.; Kaur, A.; Kaur, M.; Kumar, R.; Kumari, P.; Mehta, A.; Mittal, M.; Singh, J. B.; Walia, G.; Kumar, Ashok; Bhardwaj, A.; Choudhary, B. C.; Garg, R. B.; Keshri, S.; Malhotra, S.; Naimuddin, M.; Nishu, N.; Ranjan, K.; Sharma, R.; Sharma, V.; Bhattacharya, R.; Bhattacharya, S.; Chatterjee, K.; Dey, S.; Dutt, S.; Dutta, S.; Ghosh, S.; Majumdar, N.; Modak, A.; Mondal, K.; Mukhopadhyay, S.; Nandan, S.; Purohit, A.; Roy, A.; Roy, D.; Chowdhury, S. Roy; Sarkar, S.; Sharan, M.; Thakur, S.; Behera, P. K.; Chudasama, R.; Dutta, D.; Jha, V.; Kumar, V.; Mohanty, A. K.; Netrakanti, P. K.; Pant, L. M.; Shukla, P.; Topkar, A.; Aziz, T.; Dugad, S.; Kole, G.; Mahakud, B.; Mitra, S.; Mohanty, G. B.; Parida, B.; Sur, N.; Sutar, B.; Banerjee, S.; Bhowmik, S.; Dewanjee, R. K.; Ganguly, S.; Guchait, M.; Jain, Sa.; Kumar, S.; Maity, M.; Majumder, G.; Mazumdar, K.; Sarkar, T.; Wickramage, N.; Chauhan, S.; Dube, S.; Hegde, V.; Kapoor, A.; Kothekar, K.; Pandey, S.; Rane, A.; Sharma, S.; Behnamian, H.; Chenarani, S.; Tadavani, E. Eskandari; Etesami, S. M.; Fahim, A.; Khakzad, M.; Najafabadi, M. Mohammadi; Naseri, M.; Mehdiabadi, S. Paktinat; Hosseinabadi, F. Rezaei; Safarzadeh, B.; Zeinali, M.; Felcini, M.; Grunewald, M.; Abbrescia, M.; Calabria, C.; Caputo, C.; Colaleo, A.; Creanza, D.; Cristella, L.; De Filippis, N.; De Palma, M.; Fiore, L.; Iaselli, G.; Maggi, G.; Maggi, M.; Miniello, G.; My, S.; Nuzzo, S.; Pompili, A.; Pugliese, G.; Radogna, R.; Ranieri, A.; Selvaggi, G.; Silvestris, L.; Venditti, R.; Verwilligen, P.; Abbiendi, G.; Battilana, C.; Bonacorsi, D.; Braibant-Giacomelli, S.; Brigliadori, L.; Campanini, R.; Capiluppi, P.; Castro, A.; Cavallo, F. R.; Chhibra, S. S.; Codispoti, G.; Cuffiani, M.; Dallavalle, G. M.; Fabbri, F.; Fanfani, A.; Fasanella, D.; Giacomelli, P.; Grandi, C.; Guiducci, L.; Marcellini, S.; Masetti, G.; Montanari, A.; Navarria, F. L.; Perrotta, A.; Rossi, A. M.; Rovelli, T.; Siroli, G. P.; Tosi, N.; Albergo, S.; Costa, S.; Di Mattia, A.; Giordano, F.; Potenza, R.; Tricomi, A.; Tuve, C.; Barbagli, G.; Ciulli, V.; Civinini, C.; D'Alessandro, R.; Focardi, E.; Lenzi, P.; Meschini, M.; Paoletti, S.; Sguazzoni, G.; Viliani, L.; Benussi, L.; Bianco, S.; Fabbri, F.; Piccolo, D.; Primavera, F.; Calvelli, V.; Ferro, F.; Vetere, M. Lo; Monge, M. R.; Robutti, E.; Tosi, S.; Brianza, L.; Dinardo, M. E.; Fiorendi, S.; Gennai, S.; Ghezzi, A.; Govoni, P.; Malberti, M.; Malvezzi, S.; Manzoni, R. A.; Menasce, D.; Moroni, L.; Paganoni, M.; Pedrini, D.; Pigazzini, S.; Ragazzi, S.; Tabarelli de Fatis, T.; Buontempo, S.; Cavallo, N.; De Nardo, G.; Di Guida, S.; Esposito, M.; Fabozzi, F.; Fienga, F.; Iorio, A. O. M.; Lanza, G.; Lista, L.; Meola, S.; Paolucci, P.; Sciacca, C.; Thyssen, F.; Azzi, P.; Bacchetta, N.; Benato, L.; Bisello, D.; Boletti, A.; Carlin, R.; Carvalho Antunes De Oliveira, A.; Checchia, P.; Dall'Osso, M.; De Castro Manzano, P.; Dorigo, T.; Dosselli, U.; Gasparini, F.; Gasparini, U.; Gozzelino, A.; Lacaprara, S.; Margoni, M.; Meneguzzo, A. T.; Pazzini, J.; Pozzobon, N.; Ronchese, P.; Simonetto, F.; Torassa, E.; Zanetti, M.; Zotto, P.; Zumerle, G.; Braghieri, A.; Magnani, A.; Montagna, P.; Ratti, S. P.; Re, V.; Riccardi, C.; Salvini, P.; Vai, I.; Vitulo, P.; Solestizi, L. Alunni; Bilei, G. M.; Ciangottini, D.; Fanò, L.; Lariccia, P.; Leonardi, R.; Mantovani, G.; Menichelli, M.; Saha, A.; Santocchia, A.; Androsov, K.; Azzurri, P.; Bagliesi, G.; Bernardini, J.; Boccali, T.; Castaldi, R.; Ciocci, M. A.; Dell'Orso, R.; Donato, S.; Fedi, G.; Giassi, A.; Grippo, M. T.; Ligabue, F.; Lomtadze, T.; Martini, L.; Messineo, A.; Palla, F.; Rizzi, A.; SavoyNavarro, A.; Spagnolo, P.; Tenchini, R.; Tonelli, G.; Venturi, A.; Verdini, P. G.; Barone, L.; Cavallari, F.; Cipriani, M.; Del Re, D.; Diemoz, M.; Gelli, S.; Longo, E.; Margaroli, F.; Marzocchi, B.; Meridiani, P.; Organtini, G.; Paramatti, R.; Preiato, F.; Rahatlou, S.; Rovelli, C.; Santanastasio, F.; Amapane, N.; Arcidiacono, R.; Argiro, S.; Arneodo, M.; Bartosik, N.; Bellan, R.; Biino, C.; Cartiglia, N.; Cenna, F.; Costa, M.; Covarelli, R.; Degano, A.; Demaria, N.; Finco, L.; Kiani, B.; Mariotti, C.; Maselli, S.; Migliore, E.; Monaco, V.; Monteil, E.; Monteno, M.; Obertino, M. M.; Pacher, L.; Pastrone, N.; Pelliccioni, M.; Pinna Angioni, G. L.; Ravera, F.; Romero, A.; Ruspa, M.; Sacchi, R.; Shchelina, K.; Sola, V.; Solano, A.; Staiano, A.; Traczyk, P.; Belforte, S.; Casarsa, M.; Cossutti, F.; Ricca, G. Della; Zanetti, A.; Kim, D. H.; Kim, G. N.; Kim, M. S.; Lee, S.; Lee, S. W.; Oh, Y. D.; Sekmen, S.; Son, D. C.; Yang, Y. C.; Lee, A.; Kim, H.; Brochero Cifuentes, J. A.; Kim, T. J.; Cho, S.; Choi, S.; Go, Y.; Gyun, D.; Ha, S.; Hong, B.; Jo, Y.; Kim, Y.; Lee, B.; Lee, K.; Lee, K. S.; Lee, S.; Lim, J.; Park, S. K.; Roh, Y.; Almond, J.; Kim, J.; Lee, H.; Oh, S. B.; Radburn-Smith, B. C.; Seo, S. h.; Yang, U. K.; Yoo, H. D.; Yu, G. B.; Choi, M.; Kim, H.; Kim, J. H.; Lee, J. S. H.; Park, I. C.; Ryu, G.; Ryu, M. S.; Choi, Y.; Goh, J.; Hwang, C.; Lee, J.; Yu, I.; Dudenas, V.; Juodagalvis, A.; Vaitkus, J.; Ahmed, I.; Ibrahim, Z. A.; Komaragiri, J. R.; Md Ali, M. A. B.; Idris, F. Mohamad; Wan Abdullah, W. A. T.; Yusli, M. N.; Zolkapli, Z.; Castilla-Valdez, H.; De La Cruz-Burelo, E.; Heredia-De La Cruz, I.; Hernandez-Almada, A.; Lopez-Fernandez, R.; Villalba, R. Magaña; Guisao, J. Mejia; Sanchez-Hernandez, A.; Moreno, S. Carrillo; Barrera, C. Oropeza; Valencia, F. Vazquez; Carpinteyro, S.; Pedraza, I.; Salazar Ibarguen, H. A.; Estrada, C. Uribe; Pineda, A. Morelos; Krofcheck, D.; Butler, P. H.; Ahmad, A.; Ahmad, M.; Hassan, Q.; Hoorani, H. R.; Khan, W. A.; Saddique, A.; Shah, M. A.; Shoaib, M.; Waqas, M.; Bialkowska, H.; Bluj, M.; Boimska, B.; Frueboes, T.; Górski, M.; Kazana, M.; Nawrocki, K.; Romanowska-Rybinska, K.; Szleper, M.; Zalewski, P.; Bunkowski, K.; Byszuk, A.; Doroba, K.; Kalinowski, A.; Konecki, M.; Krolikowski, J.; Misiura, M.; Olszewski, M.; Walczak, M.; Bargassa, P.; Beirão Da Cruz E Silva, C.; Calpas, B.; Di Francesco, A.; Faccioli, P.; Ferreira Parracho, P. G.; Gallinaro, M.; Hollar, J.; Leonardo, N.; Iglesias, L. Lloret; Nemallapudi, M. V.; Antunes, J. Rodrigues; Seixas, J.; Toldaiev, O.; Vadruccio, D.; Varela, J.; Vischia, P.; Afanasiev, S.; Alexakhin, V.; Gavrilenko, M.; Golutvin, I.; Gorbunov, I.; Kamenev, A.; Karjavin, V.; Lanev, A.; Malakhov, A.; Matveev, V.; Palichik, V.; Perelygin, V.; Savina, M.; Shmatov, S.; Shulha, S.; Skatchkov, N.; Smirnov, V.; Zarubin, A.; Chtchipounov, L.; Golovtsov, V.; Ivanov, Y.; Kim, V.; Kuznetsova, E.; Murzin, V.; Oreshkin, V.; Sulimov, V.; Vorobyev, A.; Andreev, Yu.; Dermenev, A.; Gninenko, S.; Golubev, N.; Karneyeu, A.; Kirsanov, M.; Krasnikov, N.; Pashenkov, A.; Tlisov, D.; Toropin, A.; Epshteyn, V.; Gavrilov, V.; Lychkovskaya, N.; Popov, V.; Pozdnyakov, I.; Safronov, G.; Spiridonov, A.; Toms, M.; Vlasov, E.; Zhokin, A.; Bylinkin, A.; Chadeeva, M.; Markin, O.; Tarkovskii, E.; Andreev, V.; Azarkin, M.; Dremin, I.; Kirakosyan, M.; Leonidov, A.; Terkulov, A.; Baskakov, A.; Belyaev, A.; Boos, E.; Dubinin, M.; Dudko, L.; Ershov, A.; Gribushin, A.; Klyukhin, V.; Kodolova, O.; Lokhtin, I.; Miagkov, I.; Obraztsov, S.; Perfilov, M.; Petrushanko, S.; Savrin, V.; Blinov, V.; Skovpen, Y.; Shtol, D.; Azhgirey, I.; Bayshev, I.; Bitioukov, S.; Elumakhov, D.; Kachanov, V.; Kalinin, A.; Konstantinov, D.; Krychkine, V.; Petrov, V.; Ryutin, R.; Sobol, A.; Troshin, S.; Tyurin, N.; Uzunian, A.; Volkov, A.; Adzic, P.; Cirkovic, P.; Devetak, D.; Dordevic, M.; Milosevic, J.; Rekovic, V.; Maestre, J. Alcaraz; Luna, M. Barrio; Calvo, E.; Cerrada, M.; Llatas, M. Chamizo; Colino, N.; De La Cruz, B.; Peris, A. Delgado; Escalante Del Valle, A.; Bedoya, C. Fernandez; Fernández Ramos, J. P.; Flix, J.; Fouz, M. C.; Garcia-Abia, P.; Lopez, O. Gonzalez; Lopez, S. Goy; Hernandez, J. M.; Josa, M. I.; Navarro De Martino, E.; Yzquierdo, A. Pérez-Calero; Pelayo, J. Puerta; Olmeda, A. Quintario; Redondo, I.; Romero, L.; Soares, M. S.; de Trocóniz, J. F.; Missiroli, M.; Moran, D.; Cuevas, J.; Menendez, J. Fernandez; Caballero, I. Gonzalez; González Fernández, J. R.; Cortezon, E. Palencia; Cruz, S. Sanchez; Andrés, I. Suárez; Vizan Garcia, J. M.; Cabrillo, I. J.; Calderon, A.; Castiñeiras De Saa, J. R.; Curras, E.; Fernandez, M.; Garcia-Ferrero, J.; Gomez, G.; Virto, A. Lopez; Marco, J.; Rivero, C. Martinez; Matorras, F.; Gomez, J. Piedra; Rodrigo, T.; Ruiz-Jimeno, A.; Scodellaro, L.; Trevisani, N.; Vila, I.; Cortabitarte, R. Vilar; Abbaneo, D.; Auffray, E.; Auzinger, G.; Bachtis, M.; Baillon, P.; Ball, A. H.; Barney, D.; Bloch, P.; Bocci, A.; Bonato, A.; Botta, C.; Camporesi, T.; Castello, R.; Cepeda, M.; Cerminara, G.; D'Alfonso, M.; d'Enterria, D.; Dabrowski, A.; Daponte, V.; David, A.; De Gruttola, M.; De Roeck, A.; Di Marco, E.; Dobson, M.; Dorney, B.; du Pree, T.; Duggan, D.; Dünser, M.; Dupont, N.; Elliott-Peisert, A.; Fartoukh, S.; Franzoni, G.; Fulcher, J.; Funk, W.; Gigi, D.; Gill, K.; Girone, M.; Glege, F.; Gulhan, D.; Gundacker, S.; Guthoff, M.; Hammer, J.; Harris, P.; Hegeman, J.; Innocente, V.; Janot, P.; Kieseler, J.; Kirschenmann, H.; Knünz, V.; Kornmayer, A.; Kortelainen, M. J.; Kousouris, K.; Krammer, M.; Lange, C.; Lecoq, P.; Lourenço, C.; Lucchini, M. T.; Malgeri, L.; Mannelli, M.; Martelli, A.; Meijers, F.; Merlin, J. A.; Mersi, S.; Meschi, E.; Milenovic, P.; Moortgat, F.; Morovic, S.; Mulders, M.; Neugebauer, H.; Orfanelli, S.; Orsini, L.; Pape, L.; Perez, E.; Peruzzi, M.; Petrilli, A.; Petrucciani, G.; Pfeiffer, A.; Pierini, M.; Racz, A.; Reis, T.; Rolandi, G.; Rovere, M.; Ruan, M.; Sakulin, H.; Sauvan, J. B.; Schäfer, C.; Schwick, C.; Seidel, M.; Sharma, A.; Silva, P.; Sphicas, P.; Steggemann, J.; Stoye, M.; Takahashi, Y.; Tosi, M.; Treille, D.; Triossi, A.; Tsirou, A.; Veckalns, V.; Veres, G. I.; Verweij, M.; Wardle, N.; Wöhri, H. K.; Zagozdzinska, A.; Zeuner, W. D.; Bertl, W.; Deiters, K.; Erdmann, W.; Horisberger, R.; Ingram, Q.; Kaestli, H. C.; Kotlinski, D.; Langenegger, U.; Rohe, T.; Bachmair, F.; Bäni, L.; Bianchini, L.; Casal, B.; Dissertori, G.; Dittmar, M.; Donegà, M.; Grab, C.; Heidegger, C.; Hits, D.; Hoss, J.; Kasieczka, G.; Lecomte, P.; Lustermann, W.; Mangano, B.; Marionneau, M.; Martinez Ruiz del Arbol, P.; Masciovecchio, M.; Meinhard, M. T.; Meister, D.; Micheli, F.; Musella, P.; Nessi-Tedaldi, F.; Pandolfi, F.; Pata, J.; Pauss, F.; Perrin, G.; Perrozzi, L.; Quittnat, M.; Rossini, M.; Schönenberger, M.; Starodumov, A.; Tavolaro, V. R.; Theofilatos, K.; Wallny, R.; Aarrestad, T. K.; Amsler, C.; Caminada, L.; Canelli, M. F.; De Cosa, A.; Galloni, C.; Hinzmann, A.; Hreus, T.; Kilminster, B.; Ngadiuba, J.; Pinna, D.; Rauco, G.; Robmann, P.; Salerno, D.; Yang, Y.; Zucchetta, A.; Candelise, V.; Doan, T. H.; Jain, Sh.; Khurana, R.; Konyushikhin, M.; Kuo, C. M.; Lin, W.; Lu, Y. J.; Pozdnyakov, A.; Yu, S. S.; Kumar, Arun; Chang, P.; Chang, Y. H.; Chang, Y. W.; Chao, Y.; Chen, K. F.; Chen, P. H.; Dietz, C.; Fiori, F.; Hou, W.-S.; Hsiung, Y.; Liu, Y. F.; Lu, R.-S.; Moya, M. Miñano; Paganis, E.; Psallidas, A.; Tsai, J. f.; Tzeng, Y. M.; Asavapibhop, B.; Singh, G.; Srimanobhas, N.; Suwonjandee, N.; Adiguzel, A.; Cerci, S.; Damarseckin, S.; Demiroglu, Z. S.; Dozen, C.; Dumanoglu, I.; Girgis, S.; Gokbulut, G.; Guler, Y.; Hos, I.; Kangal, E. E.; Kara, O.; Topaksu, A. Kayis; Kiminsu, U.; Oglakci, M.; Onengut, G.; Ozdemir, K.; Cerci, D. Sunar; Topakli, H.; Turkcapar, S.; Zorbakir, I. S.; Zorbilmez, C.; Bilin, B.; Bilmis, S.; Isildak, B.; Karapinar, G.; Yalvac, M.; Zeyrek, M.; Gülmez, E.; Kaya, M.; Kaya, O.; Yetkin, E. A.; Yetkin, T.; Cakir, A.; Cankocak, K.; Sen, S.; Grynyov, B.; Levchuk, L.; Sorokin, P.; Aggleton, R.; Ball, F.; Beck, L.; Brooke, J. J.; Burns, D.; Clement, E.; Cussans, D.; Flacher, H.; Goldstein, J.; Grimes, M.; Heath, G. P.; Heath, H. F.; Jacob, J.; Kreczko, L.; Lucas, C.; Newbold, D. M.; Paramesvaran, S.; Poll, A.; Sakuma, T.; Seif El Nasr-storey, S.; Smith, D.; Smith, V. J.; Bell, K. W.; Belyaev, A.; Brew, C.; Brown, R. M.; Calligaris, L.; Cieri, D.; Cockerill, D. J. A.; Coughlan, J. A.; Harder, K.; Harper, S.; Olaiya, E.; Petyt, D.; Shepherd-Themistocleous, C. H.; Thea, A.; Tomalin, I. R.; Williams, T.; Baber, M.; Bainbridge, R.; Buchmuller, O.; Bundock, A.; Burton, D.; Casasso, S.; Citron, M.; Colling, D.; Corpe, L.; Dauncey, P.; Davies, G.; De Wit, A.; Negra, M. Della; Di Maria, R.; Dunne, P.; Elwood, A.; Futyan, D.; Haddad, Y.; Hall, G.; Iles, G.; James, T.; Lane, R.; Laner, C.; Lucas, R.; Lyons, L.; Magnan, A.-M.; Malik, S.; Mastrolorenzo, L.; Nash, J.; Nikitenko, A.; Pela, J.; Penning, B.; Pesaresi, M.; Raymond, D. M.; Richards, A.; Rose, A.; Seez, C.; Summers, S.; Tapper, A.; Uchida, K.; Acosta, M. Vazquez; Virdee, T.; Wright, J.; Zenz, S. C.; Cole, J. E.; Hobson, P. R.; Khan, A.; Kyberd, P.; Leslie, D.; Reid, I. D.; Symonds, P.; Teodorescu, L.; Turner, M.; Borzou, A.; Call, K.; Dittmann, J.; Hatakeyama, K.; Liu, H.; Pastika, N.; Cooper, S. I.; Henderson, C.; Rumerio, P.; West, C.; Arcaro, D.; Avetisyan, A.; Bose, T.; Gastler, D.; Rankin, D.; Richardson, C.; Rohlf, J.; Sulak, L.; Zou, D.; Benelli, G.; Berry, E.; Cutts, D.; Garabedian, A.; Hakala, J.; Heintz, U.; Hogan, J. M.; Jesus, O.; Kwok, K. H. M.; Laird, E.; Landsberg, G.; Mao, Z.; Narain, M.; Piperov, S.; Sagir, S.; Spencer, E.; Syarif, R.; Breedon, R.; Breto, G.; Burns, D.; Calderon De La Barca Sanchez, M.; Chauhan, S.; Chertok, M.; Conway, J.; Conway, R.; Cox, P. T.; Erbacher, R.; Flores, C.; Funk, G.; Gardner, M.; Ko, W.; Lander, R.; Mclean, C.; Mulhearn, M.; Pellett, D.; Pilot, J.; Shalhout, S.; Smith, J.; Squires, M.; Stolp, D.; Tripathi, M.; Bravo, C.; Cousins, R.; Dasgupta, A.; Everaerts, P.; Florent, A.; Hauser, J.; Ignatenko, M.; Mccoll, N.; Saltzberg, D.; Schnaible, C.; Takasugi, E.; Valuev, V.; Weber, M.; Burt, K.; Clare, R.; Ellison, J.; Gary, J. W.; Ghiasi Shirazi, S. M. A.; Hanson, G.; Heilman, J.; Jandir, P.; Kennedy, E.; Lacroix, F.; Long, O. R.; Negrete, M. Olmedo; Paneva, M. I.; Shrinivas, A.; Si, W.; Wei, H.; Wimpenny, S.; Yates, B. R.; Branson, J. G.; Cerati, G. B.; Cittolin, S.; Derdzinski, M.; Gerosa, R.; Holzner, A.; Klein, D.; Krutelyov, V.; Letts, J.; Macneill, I.; Olivito, D.; Padhi, S.; Pieri, M.; Sani, M.; Sharma, V.; Simon, S.; Tadel, M.; Vartak, A.; Wasserbaech, S.; Welke, C.; Wood, J.; Würthwein, F.; Yagil, A.; Zevi Della Porta, G.; Amin, N.; Bhandari, R.; Bradmiller-Feld, J.; Campagnari, C.; Dishaw, A.; Dutta, V.; Sevilla, M. Franco; George, C.; Golf, F.; Gouskos, L.; Gran, J.; Heller, R.; Incandela, J.; Mullin, S. D.; Ovcharova, A.; Qu, H.; Richman, J.; Stuart, D.; Suarez, I.; Yoo, J.; Anderson, D.; Apresyan, A.; Bendavid, J.; Bornheim, A.; Bunn, J.; Chen, Y.; Duarte, J.; Lawhorn, J. M.; Mott, A.; Newman, H. B.; Pena, C.; Spiropulu, M.; Vlimant, J. R.; Xie, S.; Zhu, R. Y.; Andrews, M. B.; Azzolini, V.; Ferguson, T.; Paulini, M.; Russ, J.; Sun, M.; Vogel, H.; Vorobiev, I.; Weinberg, M.; Cumalat, J. P.; Ford, W. T.; Jensen, F.; Johnson, A.; Krohn, M.; Mulholland, T.; Stenson, K.; Wagner, S. R.; Alexander, J.; Chaves, J.; Chu, J.; Dittmer, S.; Mcdermott, K.; Mirman, N.; Kaufman, G. Nicolas; Patterson, J. R.; Rinkevicius, A.; Ryd, A.; Skinnari, L.; Soffi, L.; Tan, S. M.; Tao, Z.; Thom, J.; Tucker, J.; Wittich, P.; Zientek, M.; Winn, D.; Abdullin, S.; Albrow, M.; Apollinari, G.; Banerjee, S.; Bauerdick, L. A. T.; Beretvas, A.; Berryhill, J.; Bhat, P. C.; Bolla, G.; Burkett, K.; Butler, J. N.; Cheung, H. W. K.; Chlebana, F.; Cihangir, S.; Cremonesi, M.; Elvira, V. D.; Fisk, I.; Freeman, J.; Gottschalk, E.; Gray, L.; Green, D.; Grünendahl, S.; Gutsche, O.; Hare, D.; Harris, R. M.; Hasegawa, S.; Hirschauer, J.; Hu, Z.; Jayatilaka, B.; Jindariani, S.; Johnson, M.; Joshi, U.; Klima, B.; Kreis, B.; Lammel, S.; Linacre, J.; Lincoln, D.; Lipton, R.; Liu, M.; Liu, T.; Lopes De Sá, R.; Lykken, J.; Maeshima, K.; Magini, N.; Marraffino, J. M.; Maruyama, S.; Mason, D.; McBride, P.; Merkel, P.; Mrenna, S.; Nahn, S.; Newman-Holmes, C.; O'Dell, V.; Pedro, K.; Prokofyev, O.; Rakness, G.; Ristori, L.; Sexton-Kennedy, E.; Soha, A.; Spalding, W. J.; Spiegel, L.; Stoynev, S.; Strait, J.; Strobbe, N.; Taylor, L.; Tkaczyk, S.; Tran, N. V.; Uplegger, L.; Vaandering, E. W.; Vernieri, C.; Verzocchi, M.; Vidal, R.; Wang, M.; Weber, H. A.; Whitbeck, A.; Wu, Y.; Acosta, D.; Avery, P.; Bortignon, P.; Bourilkov, D.; Brinkerhoff, A.; Carnes, A.; Carver, M.; Curry, D.; Das, S.; Field, R. D.; Furic, I. K.; Konigsberg, J.; Korytov, A.; Low, J. F.; Ma, P.; Matchev, K.; Mei, H.; Mitselmakher, G.; Rank, D.; Shchutska, L.; Sperka, D.; Thomas, L.; Wang, J.; Wang, S.; Yelton, J.; Linn, S.; Markowitz, P.; Martinez, G.; Rodriguez, J. L.; Ackert, A.; Adams, J. R.; Adams, T.; Askew, A.; Bein, S.; Diamond, B.; Hagopian, S.; Hagopian, V.; Johnson, K. F.; Khatiwada, A.; Prosper, H.; Santra, A.; Yohay, R.; Baarmand, M. M.; Bhopatkar, V.; Colafranceschi, S.; Hohlmann, M.; Noonan, D.; Roy, T.; Yumiceva, F.; Adams, M. R.; Apanasevich, L.; Berry, D.; Betts, R. R.; Bucinskaite, I.; Cavanaugh, R.; Evdokimov, O.; Gauthier, L.; Gerber, C. E.; Hofman, D. J.; Jung, K.; Kurt, P.; O'Brien, C.; Sandoval Gonzalez, I. D.; Turner, P.; Varelas, N.; Wang, H.; Wu, Z.; Zakaria, M.; Zhang, J.; Bilki, B.; Clarida, W.; Dilsiz, K.; Durgut, S.; Gandrajula, R. P.; Haytmyradov, M.; Khristenko, V.; Merlo, J.-P.; Mermerkaya, H.; Mestvirishvili, A.; Moeller, A.; Nachtman, J.; Ogul, H.; Onel, Y.; Ozok, F.; Penzo, A.; Snyder, C.; Tiras, E.; Wetzel, J.; Yi, K.; Anderson, I.; Blumenfeld, B.; Cocoros, A.; Eminizer, N.; Fehling, D.; Feng, L.; Gritsan, A. V.; Maksimovic, P.; Martin, C.; Osherson, M.; Roskes, J.; Sarica, U.; Swartz, M.; Xiao, M.; Xin, Y.; You, C.; Al-bataineh, A.; Baringer, P.; Bean, A.; Boren, S.; Bowen, J.; Bruner, C.; Castle, J.; Forthomme, L.; Kenny, R. P.; Khalil, S.; Kropivnitskaya, A.; Majumder, D.; Mcbrayer, W.; Murray, M.; Sanders, S.; Stringer, R.; Tapia Takaki, J. D.; Wang, Q.; Ivanov, A.; Kaadze, K.; Maravin, Y.; Mohammadi, A.; Saini, L. K.; Skhirtladze, N.; Toda, S.; Rebassoo, F.; Wright, D.; Anelli, C.; Baden, A.; Baron, O.; Belloni, A.; Calvert, B.; Eno, S. C.; Ferraioli, C.; Gomez, J. A.; Hadley, N. J.; Jabeen, S.; Kellogg, R. G.; Kolberg, T.; Kunkle, J.; Lu, Y.; Mignerey, A. C.; Ricci-Tam, F.; Shin, Y. H.; Skuja, A.; Tonjes, M. B.; Tonwar, S. C.; Abercrombie, D.; Allen, B.; Apyan, A.; Barbieri, R.; Baty, A.; Bi, R.; Bierwagen, K.; Brandt, S.; Busza, W.; Cali, I. A.; Demiragli, Z.; Di Matteo, L.; Ceballos, G. Gomez; Goncharov, M.; Hsu, D.; Iiyama, Y.; Innocenti, G. M.; Klute, M.; Kovalskyi, D.; Krajczar, K.; Lai, Y. S.; Lee, Y.-J.; Levin, A.; Luckey, P. D.; Maier, B.; Marini, A. C.; Mcginn, C.; Mironov, C.; Narayanan, S.; Niu, X.; Paus, C.; Roland, C.; Roland, G.; Salfeld-Nebgen, J.; Stephans, G. S. F.; Sumorok, K.; Tatar, K.; Varma, M.; Velicanu, D.; Veverka, J.; Wang, J.; Wang, T. W.; Wyslouch, B.; Yang, M.; Zhukova, V.; Benvenuti, A. C.; Chatterjee, R. M.; Evans, A.; Finkel, A.; Gude, A.; Hansen, P.; Kalafut, S.; Kao, S. C.; Kubota, Y.; Lesko, Z.; Mans, J.; Nourbakhsh, S.; Ruckstuhl, N.; Rusack, R.; Tambe, N.; Turkewitz, J.; Acosta, J. G.; Oliveros, S.; Avdeeva, E.; Bartek, R.; Bloom, K.; Claes, D. R.; Dominguez, A.; Fangmeier, C.; Suarez, R. Gonzalez; Kamalieddin, R.; Kravchenko, I.; Rodrigues, A. Malta; Meier, F.; Monroy, J.; Siado, J. E.; Snow, G. R.; Stieger, B.; Alyari, M.; Dolen, J.; George, J.; Godshalk, A.; Harrington, C.; Iashvili, I.; Kaisen, J.; Kharchilava, A.; Kumar, A.; Parker, A.; Rappoccio, S.; Roozbahani, B.; Alverson, G.; Barberis, E.; Hortiangtham, A.; Massironi, A.; Morse, D. M.; Nash, D.; Orimoto, T.; Teixeira De Lima, R.; Trocino, D.; Wang, R.-J.; Wood, D.; Bhattacharya, S.; Charaf, O.; Hahn, K. A.; Kubik, A.; Kumar, A.; Mucia, N.; Odell, N.; Pollack, B.; Schmitt, M. H.; Sung, K.; Trovato, M.; Velasco, M.; Dev, N.; Hildreth, M.; Anampa, K. Hurtado; Jessop, C.; Karmgard, D. J.; Kellams, N.; Lannon, K.; Marinelli, N.; Meng, F.; Mueller, C.; Musienko, Y.; Planer, M.; Reinsvold, A.; Ruchti, R.; Smith, G.; Taroni, S.; Wayne, M.; Wolf, M.; Woodard, A.; Alimena, J.; Antonelli, L.; Brinson, J.; Bylsma, B.; Durkin, L. S.; Flowers, S.; Francis, B.; Hart, A.; Hill, C.; Hughes, R.; Ji, W.; Liu, B.; Luo, W.; Puigh, D.; Winer, B. L.; Wulsin, H. W.; Cooperstein, S.; Driga, O.; Elmer, P.; Hardenbrook, J.; Hebda, P.; Lange, D.; Luo, J.; Marlow, D.; Mc Donald, J.; Medvedeva, T.; Mei, K.; Mooney, M.; Olsen, J.; Palmer, C.; Piroué, P.; Stickland, D.; Svyatkovskiy, A.; Tully, C.; Zuranski, A.; Malik, S.; Barker, A.; Barnes, V. E.; Folgueras, S.; Gutay, L.; Jha, M. K.; Jones, M.; Jung, A. W.; Miller, D. H.; Neumeister, N.; Schulte, J. F.; Shi, X.; Sun, J.; Wang, F.; Xie, W.; Parashar, N.; Stupak, J.; Adair, A.; Akgun, B.; Chen, Z.; Ecklund, K. M.; Geurts, F. J. M.; Guilbaud, M.; Li, W.; Michlin, B.; Northup, M.; Padley, B. P.; Redjimi, R.; Roberts, J.; Rorie, J.; Tu, Z.; Zabel, J.; Betchart, B.; Bodek, A.; de Barbaro, P.; Demina, R.; Duh, Y. t.; Ferbel, T.; Galanti, M.; Garcia-Bellido, A.; Han, J.; Hindrichs, O.; Khukhunaishvili, A.; Lo, K. H.; Tan, P.; Verzetti, M.; Agapitos, A.; Chou, J. P.; Contreras-Campana, E.; Gershtein, Y.; Gómez Espinosa, T. A.; Halkiadakis, E.; Heindl, M.; Hidas, D.; Hughes, E.; Kaplan, S.; Elayavalli, R. Kunnawalkam; Kyriacou, S.; Lath, A.; Nash, K.; Saka, H.; Salur, S.; Schnetzer, S.; Sheffield, D.; Somalwar, S.; Stone, R.; Thomas, S.; Thomassen, P.; Walker, M.; Delannoy, A. G.; Foerster, M.; Heideman, J.; Riley, G.; Rose, K.; Spanier, S.; Thapa, K.; Bouhali, O.; Celik, A.; Dalchenko, M.; De Mattia, M.; Delgado, A.; Dildick, S.; Eusebi, R.; Gilmore, J.; Huang, T.; Juska, E.; Kamon, T.; Mueller, R.; Pakhotin, Y.; Patel, R.; Perloff, A.; Perniè, L.; Rathjens, D.; Rose, A.; Safonov, A.; Tatarinov, A.; Ulmer, K. A.; Akchurin, N.; Cowden, C.; Damgov, J.; De Guio, F.; Dragoiu, C.; Dudero, P. R.; Faulkner, J.; Gurpinar, E.; Kunori, S.; Lamichhane, K.; Lee, S. W.; Libeiro, T.; Peltola, T.; Undleeb, S.; Volobouev, I.; Wang, Z.; Greene, S.; Gurrola, A.; Janjam, R.; Johns, W.; Maguire, C.; Melo, A.; Ni, H.; Sheldon, P.; Tuo, S.; Velkovska, J.; Xu, Q.; Arenton, M. W.; Barria, P.; Cox, B.; Goodell, J.; Hirosky, R.; Ledovskoy, A.; Li, H.; Neu, C.; Sinthuprasith, T.; Sun, X.; Wang, Y.; Wolfe, E.; Xia, F.; Clarke, C.; Harr, R.; Karchin, P. E.; Sturdy, J.; Belknap, D. A.; Buchanan, J.; Caillol, C.; Dasu, S.; Dodd, L.; Duric, S.; Gomber, B.; Grothe, M.; Herndon, M.; Hervé, A.; Klabbers, P.; Lanaro, A.; Levine, A.; Long, K.; Loveless, R.; Ojalvo, I.; Perry, T.; Pierro, G. A.; Polese, G.; Ruggles, T.; Savin, A.; Smith, N.; Smith, W. H.; Taylor, D.; Woods, N.

2017-03-01

A search for new particles has been conducted using events with two high transverse momentum ( p T) τ leptons that decay hadronically, at least two high- p T jets, and missing transverse energy from the τ lepton decays. The analysis is performed using data from proton-proton collisions, collected by the CMS experiment in 2015 at √{s}=13 TeV, corresponding to an integrated luminosity of 2.1 fb-1. The results are interpreted in two physics models. The first model involves heavy right-handed neutrinos, Nℓ ( ℓ = e , μ, τ), and right-handed charged bosons, WR, arising in a left-right symmetric extension of the standard model. Masses of the WR boson below 2.35 (1.63) TeV are excluded at 95% confidence level, assuming the N τ mass is 0.8 (0.2) times the mass of the WR boson and that only the N τ flavor contributes to the WR decay width. In the second model, pair production of third-generation scalar leptoquarks that decay into ττbb is considered. Third-generation scalar leptoquarks with masses below 740 GeV are excluded, assuming a 100% branching fraction for the leptoquark decay to a τ lepton and a bottom quark. This is the first search at hadron colliders for the third-generation Majorana neutrino, as well as the first search for third-generation leptoquarks in the final state with a pair of hadronically decaying τ leptons and jets. [Figure not available: see fulltext.

"Chase CRP", "Review patient": Improving the Quality of Weekend Medical Handover at a London Teaching Hospital.

PubMed

Saifuddin, Aamir; Magee, Lucia; Barrett, Rachael

2015-01-01

Clinical handover has been identified as a "major preventable cause of harm" by the Royal College of Physicians (RCP). Whilst working at a London teaching hospital from August 2013, we noted substandard weekend handover of medical patients. The existing pro forma was filled incompletely by day doctors so it was difficult for weekend colleagues to identify unwell patients, with inherent safety implications. Furthermore, on-call medical staff noted that poor accessibility of vital information in patients' files was affecting acute clinical management. We audited the pro formas over a six week period (n=83) and the Friday ward round (WR) entries for medical inpatients over two weekends (n=84) against the RCP's handover guidance. The results showed poor documentation of several important details on the pro formas, for example, ceiling of care (4%) and past medical history (PMH) (23%). Problem lists were specified on 62% of the WR entries. We designed new handover pro formas and 'Friday WR sheets' to provide prompts for this information and used Medical Meetings and emails to explain the project's aims. Re-audit demonstrated significant improvement in all parameters; for instance, PMH increased to 52% on the pro formas. Only 10% of Friday WR entries used our sheet. However, when used, outcomes were much better, for example, problem list documentation increased to 100%. In conclusion, our interventions improved the provision of crucial information needed to prioritise and manage patients over the weekend. Future work should further highlight the importance of safe handover to all doctors to induce a shift in culture and optimise patient care.

Search for heavy neutrinos or third-generation leptoquarks in final states with two hadronically decaying τ leptons and two jets in proton-proton collisions at $$ \\sqrt{s}=13$$ TeV

DOE PAGES

Khachatryan, V.; Sirunyan, A. M.; Tumasyan, A.; ...

2017-03-14

A search for new particles has been conducted using events with two high transverse momentum (p T) τ leptons that decay hadronically, at least two high-p T jets, and missing transverse energy from the τ lepton decays. The analysis is performed using data from proton-proton collisions, collected by the CMS experiment in 2015 at √s = 13 TeV, corresponding to an integrated luminosity of 2.1 fb –1. The results are interpreted in two physics models. The first model involves heavy right-handed neutrinos, N ℓ (ℓ = e, μ, τ), and right-handed charged bosons, WR, arising in a left-right symmetric extensionmore » of the standard model. Masses of the WR boson below 2.35 (1.63) TeV are excluded at 95% confidence level, assuming the Nτ mass is 0.8 (0.2) times the mass of the WR boson and that only the Nτ flavor contributes to the WR decay width. In the second model, pair production of third-generation scalar leptoquarks that decay into ττbb is considered. Third-generation scalar leptoquarks with masses below 740 GeV are excluded, assuming a 100% branching fraction for the leptoquark decay to a τ lepton and a bottom quark. Finally, this is the first search at hadron colliders for the third-generation Majorana neutrino, as well as the first search for third-generation leptoquarks in the final state with a pair of hadronically decaying τ leptons and jets.« less

The hypolipidemic action of a diet supplemented with p,p'-methoxyl-diphenyl diselenide is not directly related to its antioxidant property.

PubMed

Sartori Oliveira, Carla Elena; Pinton, Simone; da Rocha, Juliana Trevisan; Gai, Bibiana Mozzaquatro; Nogueira, Cristina Wayne

2016-06-01

The present study investigated whether a p,p'-methoxyl-diphenyl diselenide (MeOPhSe)2-supplemented diet causes toxicity in rats. A second aim of this study was to determine whether a 10 ppm (MeOPhSe)2-supplemented diet has hypolipidemic effect on Triton WR-1339-induced hyperlipidemia in rats. To rule out the antioxidant property of (MeOPhSe)2 in its hypolipidemic action, parameters of oxidative stress were carried out. Wistar rats were fed with 3, 10, or 30 ppm of (MeOPhSe)2-supplemented diet for 30 days. None of (MeOPhSe)2-supplemented diets caused alteration in general parameters of toxicity and lipid profile of rats. The hypolipidemic effect of 10 ppm of (MeOPhSe)2-supplemented diet on rats treated with Triton WR-1339 (400 mg/kg, intraperitoneal) was investigated. The (MeOPhSe)2-supplemented diet partially protected against the levels of total cholesterol (TC) and non-HDL-C and reduced the atherogenic index (AI) increased by Triton WR-1339 in rats. A positive correlation between TC and triglyceride levels (r = 0.679) and non-HDL-C levels (r = 0.929) and AI (r = 0.889) was demonstrated. Triton WR-1339 altered parameters of oxidative stress in livers of rats but (MeOPhSe)2-supplemented diet did not protect against these alterations. The results demonstrated that the hypolipidemic action of (MeOPhSe)2-supplemented diet is not directly related to its antioxidant property and devoid of systemic toxicity in rats at the parameters analyzed.

WR and LBV stars

NASA Astrophysics Data System (ADS)

Kochiashvili, Nino; Beradze, Sophie; Kochiashvili, Ia; Natsvlishvili, Rezo; Vardosanidze, Manana

Evolutionary scenarios of massive stars were revised in recent decades, after finding "unusual", blue progenitor of SN 1987A and after detecting the more massive stars than the accepted 120 M ⊙ maximum limit of stellar masses. A very important relation exists between WR and LBV stars. They represent the earlier, pre-SN evolutionary states of massive stars. WR and LBV stars and "classic" evolutionary scheme of the relation between the different type massive stars are discussed in this article. There also exist the newest evolutionary scenarios for low metallicity massive stars, which give us a different picture of their post main-sequence evolution. There is a rather good tradition of observations and investigations of massive stars at Abastumani Astrophysical Observatory. The authors discuss the new findings on the fate of P Cygni, the LBV star. These results on the reddening of the star and about its next possible outburst in the near future were obtained on the basis of UBV long-term electrophotometric observations of P Cygni by Eugene Kharadze and Nino Magalashvili. The observations were held in 1951-1983 at Abastumani Observatory using 33-cm and 48-cm reflectors.

First Spectra of O Stars in R136A

NASA Astrophysics Data System (ADS)

Heap, Sara

1994-01-01

Hubble images of the cluster, R136a, in the LMC indicate that the cluster contains 3 Wolf-Rayet stars, R136a1,-a2, and a3 (Campbell et al. 1992) and numerous O and B-type stars. Although models for WR stars are not well enough developed to infer the basic parameters of the 3 WR stars in R136a, models for O stars are well well established, and they suggest that the O stars in R136a are relatively normal, having initial masses no higher than 60 Msun (Heap et al. 1992, Malumuth & Heap 1992, di Marchi et al. 1993); there are no unusual "super-massive" stars in R136a. With HST/GHRS/CoSTAR, it will be possible to obtain spectra of an O star in R136a without contam- ination by WR stars. These spectra will be able to confirm or invalidate the photometric results. Thus, these spectra will have implications both for the population of R136a and for the validity of stellar population studies of giant extragalactic HII regions and starbursts that are based entirely on photometry.

Mass-losing M supergiants in the solar neighborhood

NASA Technical Reports Server (NTRS)

Jura, M.; Kleinmann, S. G.

1990-01-01

A list of the 21 mass-losing red supergiants (20 M type, one G type; L greater than 100,000 solar luminosities) within 2.5 kpc of the sun is compiled. These supergiants are highly evolved descendants of main-sequence stars with initial masses larger than 20 solar masses. The surface density is between about 1 and 2/sq kpc. As found previously, these stars are much less concentrated toward the Galactic center than W-R stars, which are also highly evolved massive stars. Although with considerable uncertainty, it is estimated that the mass return by the M supergiants is somewhere between 0.00001 and 0.00003 solar mass/sq kpc yr. In the hemisphere facing the Galactic center there is much less mass loss from M supergiants than from W-R stars, but, in the anticenter direction, the M supergiants return more mass than do the W-R stars. The duration of the M supergiant phase appears to be between 200,000 and 400,000 yr. During this phase, a star of initially at least 20 solar masses returns perhaps 3-10 solar masses into the interstellar medium.

Radiation protection issues in galactic cosmic ray risk assessment

NASA Technical Reports Server (NTRS)

Sinclair, W. K.

1994-01-01

Radiation protection involves the limitation of exposure to below threshold doses for direct (or deterministic) effects and a knowledge of the risk of stochastic effects after low doses. The principal stochastic risk associated with low dose rate galactic cosmic rays is the increased risk of cancer. Estimates of this risk depend on two factors (a) estimates of cancer risk for low-LET radiation and (b) values of the appropriate radiation weighting factors, WR, for the high-LET radiations of galactic cosmic rays. Both factors are subject to considerable uncertainty. The low-LET cancer risk derived from the late effects of the atomic bombs is vulnerable to a number of uncertainties including especially that from projection in time, and from extrapolation from high to low dose rate. Nevertheless, recent low dose studies of workers and others tend to confirm these estimates. WR, relies on biological effects studied mainly in non-human systems. Additional laboratory studies could reduce the uncertainties in WR and thus produce a more confident estimate of the overall risk of galactic cosmic rays.

Luminous blue variables and the fates of very massive stars.

PubMed

Smith, Nathan

2017-10-28

Luminous blue variables (LBVs) had long been considered massive stars in transition to the Wolf-Rayet (WR) phase, so their identification as progenitors of some peculiar supernovae (SNe) was surprising. More recently, environment statistics of LBVs show that most of them cannot be in transition to the WR phase after all, because LBVs are more isolated than allowed in this scenario. Additionally, the high-mass H shells around luminous SNe IIn require that some very massive stars above 40  M ⊙ die without shedding their H envelopes, and the precursor outbursts are a challenge for understanding the final burning sequences leading to core collapse. Recent evidence suggests a clear continuum in pre-SN mass loss from super-luminous SNe IIn, to regular SNe IIn, to SNe II-L and II-P, whereas most stripped-envelope SNe seem to arise from a separate channel of lower-mass binary stars rather than massive WR stars.This article is part of the themed issue 'Bridging the gap: from massive stars to supernovae'. © 2017 The Author(s).

Energy and emission aspects of co-combustion solid recovered fuel with coal in a stoker boiler

NASA Astrophysics Data System (ADS)

Wasielewski, Ryszard; Głód, Krzysztof; Telenga-Kopyczyńska, Jolanta

2018-01-01

The results of industrial research on co-combustion of solid recovered fuel (SRF) with hard coal in a stoker boiler type WR-25 has been presented. The share of SRF in the fuel mixture was 10%. During the co-combustion of SRF, no technological disturbances or significant reduction in energy efficiency of the boiler were noted. Obtained SO2, NOx and CO emissions were comparable with coal combustion but dust emissions increased. During combustion of the coal mixture with a 10% share of SRF in the test boiler WR-25, the emission standards established for the combustion of the dedicated fuel were met. However, comparison of obtained emission results with the emission standards established for co-incineration of waste, revealed the exceedance of permissible levels of HCl, dust, heavy metals, dioxins and furans. Additionally, the residence time of flue gases in over 850°C conditions for the test boiler WR-25 was too short (1.3 seconds) in refer to the legislative requirements (2 seconds) for the thermal conversion of waste.

Antiviral Activity of Fridericia formosa (Bureau) L. G. Lohmann (Bignoniaceae) Extracts and Constituents

PubMed Central

Brandão, Geraldo Célio; Kroon, Erna G.; Souza Filho, José D.

2017-01-01

A phytochemical study of Fridericia formosa (Bignoniaceae) ethanol extracts of leaves, stems, and fruits was guided by in vitro assays against vaccinia virus Western Reserve (VACV-WR), human herpes virus 1 (HSV-1), murine encephalomyocarditis virus (EMCV), and dengue virus type 2 (DENV-2) by the MTT method. All the ethanol extracts were active against DENV-2, HSV-1, and VACV-WR with best results for the fruits extract against DENV-2 (SI > 38.2). For VACV-WR and HSV-1, EC50 values > 200 μg mL−1 were determined, while no inhibition of the cytopathic effect was observed with EMCV. Five compounds were isolated and identified as the C-glucosylxanthones mangiferin (1), 2′-O-trans-caffeoylmangiferin (2), 2′-O-trans-coumaroylmangiferin (3), 2′-O-trans-cinnamoylmangiferin (5), and the flavonoid chrysin (4). The most active compound was 2′-O-trans-coumaroylmangiferin (3) with SI > 121.9 against DENV-2 and 108.7 for HSV-1. These results indicate that mangiferin cinnamoyl esters might be potential antiviral drugs. PMID:28634494

Evaluation of selected antiprotozoal drugs in the Babesia microti-hamster model.

PubMed Central

Marley, S E; Eberhard, M L; Steurer, F J; Ellis, W L; McGreevy, P B; Ruebush, T K

1997-01-01

The presently used therapy for Babesia microti infections, a combination of quinine and clindamycin, does not always result in parasitologic cures. To identify possible alternative chemotherapeutic agents for such infections, we screened, in the hamster-B. microti system, 12 antiprotozoal drugs that have either recently been released for human use or were in experimental stages of development at the Walter Reed Army Institute of Research for the treatment of malaria and leishmaniasis. Several well-recognized antimalarial drugs, such as mefloquine, halofantrine, artesunate, and artelenic acid, exhibited little or no effect on parasitemia. Two 8-aminoquinolines, WR006026 [8-(6-diethylaminohexylamino)-6-methoxy-4-methylquinoline dihydrochloride] and WR238605 [8-[(4-amino-1-methylbutyl)amino]-2,6-dimethoxy-4-methyl-5 -(3-trifluoromethylphenoxy-7) quinoline succinate], produced clearance of patent parasitemia. Furthermore, blood from infected hamsters treated with WR238605 via an intramuscular injection failed to infect naive hamsters on subpassage, thus producing a parasitologic cure. These two compounds merit further screening in other systems and may prove useful in treating human babesiosis. PMID:8980761

Cisplatin neuropathy. Risk factors, prognosis, and protection by WR-2721

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mollman, J.E.; Glover, D.J.; Hogan, W.M.

1988-06-01

A prospective study of patients receiving cis-diaminedichloroplatin II (DDP) was carried out to determine if risk factors could be identified related to the patient's living habits or past medical history that would predict in which patients DDP neuropathy might develop. Sixty-nine patients receiving six different combinations of chemotherapeutic agents, including DDP were examined. Twenty-eight of these patients received DDP in combination with the radioprotective agent S-2-(3-aminopropylamino)-ethylphosporothioic acid (WR 2721). No risk factors were identified relating to personal habits or past medical history of the patients. However, patients receiving DDP (40 mg/m2) on 5 consecutive days had a significantly higher incidencemore » of neuropathy. Patients receiving DDP in combination with WR 2721 had a significantly lower incidence of neuropathy, and the mean dose at onset was significantly higher than the mean dose at onset of neuropathy for all other groups. In addition, five of six patients who were available for long-term follow-up demonstrated nearly complete reversal of the signs and symptoms of neuropathy.« less

Radiation protection issues in galactic cosmic ray risk assessment.

PubMed

Sinclair, W K

1994-01-01

Radiation protection involves the limitation of exposure to below threshold doses for direct (or deterministic) effects and a knowledge of the risk of stochastic effects after low doses. The principal stochastic risk associated with low dose rate galactic cosmic rays is the increased risk of cancer. Estimates of this risk depend on two factors (a) estimates of cancer risk for low-LET radiation and (b) values of the appropriate radiation weighting factors, WR, for the high-LET radiations of galactic cosmic rays. Both factors are subject to considerable uncertainty. The low-LET cancer risk derived from the late effects of the atomic bombs is vulnerable to a number of uncertainties including especially that from projection in time, and from extrapolation from high to low dose rate. Nevertheless, recent low dose studies of workers and others tend to confirm these estimates. WR, relies on biological effects studied mainly in non-human systems. Additional laboratory studies could reduce the uncertainties in WR and thus produce a more confident estimate of the overall risk of galactic cosmic rays.

Neuropsychological and Cognitive Correlates of Recovery in Anorexia Nervosa.

PubMed

Harper, Jessica A; Brodrick, Brooks; Van Enkevort, Erin; McAdams, Carrie J

2017-11-01

To identify clinical or cognitive measures either predictive of illness trajectory or altered with sustained weight recovery in adult women with anorexia nervosa. Participants were recruited from prior studies of women with anorexia nervosa (AN-C) and in weight-recovery following anorexia nervosa (AN-WR). Participants completed a neuropsychological battery at baseline and clinical assessments at both baseline and follow-up. Groups based on clinical outcome (continued eating disorder, AN-CC; newly in recovery, AN-CR; sustained weight-recovery, AN-WR) were compared by using one-way ANOVAs with Bonferroni-corrected post hoc comparisons. Women with continued eating disorder had poorer neuropsychological function and self-competence at baseline than AN-CR. AN-CR showed changes in depression and externalizing bias, a measure of self-related attributions. AN-WR differed from both AN-CC and AN-CR at baseline in externalizing bias, but only from AN-CC at outcome. Neuropsychological function when recently ill may be a prognostic factor, while externalizing bias may provide a clinical target for recovery. Copyright © 2017 John Wiley & Sons, Ltd and Eating Disorders Association. Copyright © 2017 John Wiley & Sons, Ltd and Eating Disorders Association.

First Visual Orbit for the Prototypical Colliding-wind Binary WR 140

NASA Astrophysics Data System (ADS)

Monnier, John D.; Zhao, M.; Pedretti, E.; Millan-Gabet, R.; Berger, J.; Schloerb, F.; Traub, W.; ten Brummelaar, T.; McAlister, H.; Ridgway, S.; Turner, N.; Sturmann, L.; Sturmann, J.; Baron, F.; Tannirkulam, A.; Kraus, S.; Williams, P.

2012-01-01

Wolf-Rayet stars represent one of the final stages of massive stellar evolution. Relatively little is known about this short-lived phase and we currently lack reliable mass, distance, and binarity determinations for a representative sample. Here we report the first visual orbit for WR 140 (=HD193793), a WC7+O5 binary system known for its periodic dust production episodes triggered by intense colliding winds near periastron passage. The IOTA and CHARA interferometers resolved the pair of stars in each year from 2003--2009, covering most of the highly-eccentric, 7.9 year orbit. Combining our results with the recent improved double-line spectroscopic orbit of Fahed et al. (2011), we can estimate the distance to WR 140 with about 2% error and estimate component masses with about 4% error. Our precision orbit yields key parameters with uncertainties about 6 times smaller than previous work and paves the way for detailed modeling of the system. Our newly measured flux ratios at the near-infrared H and Ks bands allow an SED decomposition and analysis of the component evolutionary states.

Association between wrist ratio and carpal tunnel syndrome: Effect modification by body mass index.

PubMed

Thiese, Matthew S; Merryweather, Andrew; Koric, Alzina; Ott, Ulrike; Wood, Eric M; Kapellusch, Jay; Foster, James; Garg, Arun; Deckow-Schaefer, Gwen; Tomich, Suzanna; Kendall, Richard; Drury, David L; Wertsch, Jacqueline; Hegmann, Kurt T

2017-12-01

Previous studies have reported higher wrist ratios (WR) related to carpal tunnel syndrome (CTS) but have not assessed effect modification by obesity and may have inadequately controlled for confounders. Baseline data of a multicenter prospective cohort study were analyzed. CTS was defined by nerve conduction study (NCS) criteria and symptoms. Among the 1,206 participants, a square-shaped wrist was associated with CTS after controlling for confounders (prevalence ratio = 2.27; 95% confidence interval [95% CI], 1.33-3.86). Body mass index (BMI) was a strong effect modifier on the relationship between WR and both CTS and abnormal NCS results, with normal weight strata of rectangular versus square wrists = 8.18 (95% CI, 1.63-49.96) and 7.12 (95% CI, 2.19-23.16), respectively. A square wrist is significantly associated with CTS after controlling for confounders. Effect modification by high BMI masked the eightfold magnitude adjusted relationship seen between WR and CTS among normal weight participants. Muscle Nerve 56: 1047-1053, 2017. © 2017 Wiley Periodicals, Inc.

Beyond G-band : a 235 GHz InP MMIC amplifier

NASA Technical Reports Server (NTRS)

Dawson, Douglas; Samoska, Lorene; Fung, A. K.; Lee, Karen; Lai, Richard; Grundbacher, Ronald; Liu, Po-Hsin; Raja, Rohit

2005-01-01

We present results on an InP monolithic millimeter- wave integrated circuit (MMIC) amplifier having 10-dB gain at 235 GHz. We designed this circuit and fabricated the chip in Northrop Grumman Space Technology's (NGST) 0.07- m InP high electron mobility transistor (HEMT) process. Using a WR3 (220-325 GHz) waveguide vector network analyzer system interfaced to waveguide wafer probes, we measured this chip on-wafer for -parameters. To our knowledge, this is the first time a WR3 waveguide on-wafer measurement system has been used to measure gain in a MMIC amplifier above 230 GHz.

New Galactic Candidate Luminous Blue Variables and Wolf-Rayet Stars

NASA Astrophysics Data System (ADS)

Stringfellow, Guy S.; Gvaramadze, Vasilii V.; Beletsky, Yuri; Kniazev, Alexei Y.

2012-04-01

We have undertaken a near-infrared spectral survey of stars associated with compact mid-IR shells recently revealed by the MIPSGAL (24 μm) and GLIMPSE (8 μm) Spitzer surveys, whose morphologies are typical of circumstellar shells produced by massive evolved stars. Through spectral similarity with known Luminous Blue Variable (LBV) and Wolf-Rayet (WR) stars, a large population of candidate LBVs (cLBVs) and a smaller number of new WR stars are being discovered. This significantly increases the Galactic cLBV population and confirms that nebulae are inherent to most (if not all) objects of this class.

A high-performance wave guide cryogenic thermal break

NASA Astrophysics Data System (ADS)

Melhuish, S. J.; McCulloch, M. A.; Piccirillo, L.; Stott, C.

2016-10-01

We describe a high-performance wave guide cryogenic thermal break. This has been constructed both for Ka band, using WR28 wave guide, and Q band, using WR22 wave guide. The mechanical structure consists of a hexapod (Stewart platform) made from pultruded carbon fibre tubing. We present a tentative examination of the cryogenic Young's modulus of this material. The thermal conductivity is measured at temperatures above the range explored by Runyan and Jones, resulting in predicted conductive loads through our thermal breaks of 3.7 mW to 3 K and 17 μK to 1 K.

Physiological responses of juvenile rainbow trout to fasting and swimming activity: Effects on body composition and condition indices

USGS Publications Warehouse

Simpkins, D.G.; Hubert, W.A.; Del Rio, C.M.; Rule, D.C.

2003-01-01

The physiological traits that allow fish to survive periods of limited food resources are poorly understood. We assessed changes in proximate body composition, relative organ mass, blood metabolites, and relative weight (Wr) of sedentary and actively swimming (15 cm/s) juvenile rainbow trout (154-182 mm total length) over 147 d of fasting. Fasting caused measurable responses that were augmented when fish were swimming. Lipids and plasma triacylglycerides declined over time. Proteins were catabolized simultaneously with lipid reserves, but ammonia concentrations in plasma did not increase. The liver somatic index (LSI) did not change substantially over 105 d, suggesting that gluconeogenesis maintained blood glucose concentrations and hepatic glycogen reserves for a substantial period of fasting. The gut somatic index (GSI) and Wr declined linearly during fasting, but the LSI did not decline until after 105 d of fasting. Consequently, the use of different body condition indices could lead to different conclusions about the condition of juvenile rainbow trout. Swimming activity caused fish to have lower lipid and protein reserves than those of sedentary fish. No mortalities were observed among sedentary fish, but mortalities occurred among actively swimming fish after 97 d of fasting when 3.2% or less lipid remained in their bodies. Body condition indices did not account for differences in proximate body composition between sedentary and actively swimming fish and were relatively poor predictors of lipid content and risk of mortality. The probability of mortality was most accurately predicted by percent lipid content. Therefore, we suggest that fisheries scientists consider using percent lipid content when evaluating the physiological status and risk of mortality due to starvation among juvenile rainbow trout.

Parent-Flare Emission at 2.8 GHz as a Predictor of the Peak Absorption of Polar-Cap Events.

DTIC Science & Technology

1976-12-01

Technical Report 20 15 ( TR 20 15) ____________________________ i n ~~~~~~~~~~~ o ~~~~ - - S TAPE OF 9EPçJ~~~ & Pf RIOO C O V E R E O ~~‘ J~ARENT...i11 ( , is iehl i , WR lt , t u 1 , . 11 , tr id I \\ .ii ~~~~~ I 07 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ l ’ABLF I - RF\\ ’l I :W 01: Ml...1 1 ,0 C) 10 > ~t tas I” 1154$ 313 N2S .W32 ,55~ 5 0 ISO 4 N 0$ N1 I ’. (17 USSr ’ 213 St S .W02 ‘1047 I 000 0.’) N~ I I 0’) Lii i (~S t) S54 313

Prediction of physical and chemical body compositions of purebred and crossbred Nellore cattle using the composition of a rib section.

PubMed

Marcondes, M I; Tedeschi, L O; Valadares Filho, S C; Chizzotti, M L

2012-04-01

The goal of this research was to develop empirical equations to predict chemical and physical compositions of the carcass and the body using the composition of the 9th- to 11th-rib section (rib(9-11)) and other measurements. A database (n = 246) from 6 studies was developed and comprised 37 bulls (BU), 115 steers (STR), and 94 heifers (HF), of which 132 were Nellore (NEL), 76 were NEL × Angus crossbreds (NA), and 38 were NEL × Simmental crossbreds (NS). The right half carcass and the rib(9-11) from the left half carcass were analyzed for ether extract (EE), CP, and water. The remaining components were chemically analyzed to determine the composition of the body. A stepwise procedure was used to determine the variable inclusion in the regression models. The variables included were EE in the rib(9-11) (EER; %), CP in the rib(9-11) (CPR; %), water in the rib(9-11) (WR; %), visceral fat (VF; %; KPH and mesenteric fats), organs plus viscera (OV; %), carcass dressing percentage (CD; %), cold carcass weight (kg), and empty BW (EBW; kg). No sex or breed effects were found on EE and CP compositions of the carcass (C(EE) and C(CP), respectively; %); the equations were as follows: C(EE) = 4.31 + 0.31 × EER + 1.37 × VF [n = 241; R(2) = 0.83; mean square error (MSE) = 4.53] and C(CP) = 17.92 + 0.60 × CPR - 0.17 × CD (n = 238; R(2) = 0.50; MSE = 1.58). Breed affected water content in the carcass (C(W), %); the equations were as follows: C(W) = 48.74 + 0.28 × WR - 0.017 × EBW for NEL; C(W) = 46.69 + 0.32 × WR - 0.017 × EBW for NA; and C(W) = 38.06 + 0.48 × WR - 0.017 × EBW for NS (n = 243; R(2) = 0.67; MSE = 5.17). A sex effect was found on body chemical EE composition (BW(EE)); the equations were as follows: BW(EE) = 2.75 + 0.33 × EER + 1.80 × VF for BU; BW(EE) = 1.84 + 0.33 × EER + 1.91 × VF for STR; and BW(EE) = 4.77 + 0.33 × EER + 1.28 × VF for HF (n = 243; R(2) = 0.89; MSE = 3.88). No sex or breed effects were found on CP composition in the body (BW(CP)); the equation was as follows: BW(CP) = 14.38 + 0.24 × CPR (n = 240; R(2) = 0.59; MSE = 1.06). A sex effect was found for body water content (BW(W)); the equations were as follows: BW(W) = 38.31 + 0.33 × WR - 1.09 × VF + 0.50 × OV for BU; BW(W) = 45.67 + 0.25 × WR - 1.89 × VF + 0.50 × OV for STR; and BW(W) = 31.61 + 0.47 × WR - 1.06 × VF + 0.50 × OV for HF (n = 241; R(2) = 0.81; MSE = 3.84). The physical carcass composition indicated a breed effect on all components and a sex effect for fat in the carcass. We conclude that body and carcass compositions can be estimated with rib(9-11) for purebred and crossbred NEL animals, but specific equations have to be developed for different groups of animals.

Brilliant Star in a Colourful Neighbourhood

NASA Astrophysics Data System (ADS)

2010-07-01

A spectacular new image from ESO's Wide Field Imager at the La Silla Observatory in Chile shows the brilliant and unusual star WR 22 and its colourful surroundings. WR 22 is a very hot and bright star that is shedding its atmosphere into space at a rate many millions of times faster than the Sun. It lies in the outer part of the dramatic Carina Nebula from which it formed. Very massive stars live fast and die young. Some of these stellar beacons have such intense radiation passing through their thick atmospheres late in their lives that they shed material into space many millions of times more quickly than relatively sedate stars such as the Sun. These rare, very hot and massive objects are known as Wolf-Rayet stars [1], after the two French astronomers who first identified them in the mid-nineteenth century, and one of the most massive ones yet measured is known as WR 22. It appears at the centre of this picture, which was created from images taken through red, green and blue filters with the Wide Field Imager on the MPG/ESO 2.2-metre telescope at ESO's La Silla Observatory in Chile. WR 22 is a member of a double star system and has been measured to have a mass at least 70 times that of the Sun. WR 22 lies in the southern constellation of Carina, the keel of Jason's ship Argo in Greek mythology. Although the star lies over 5000 light-years from the Earth it is so bright that it can just be faintly seen with the unaided eye under good conditions. WR 22 is one of many exceptionally brilliant stars associated with the beautiful Carina Nebula (also known as NGC 3372) and the outer part of this huge region of star formation in the southern Milky Way forms the colourful backdrop to this image. The subtle colours of the rich background tapestry are a result of the interactions between the intense ultraviolet radiation coming from hot massive stars, including WR 22, and the vast gas clouds, mostly hydrogen, from which they formed. The central part of this enormous complex of gas and dust lies off the left side of this picture as can be seen in image eso1031b. This area includes the remarkable star Eta Carinae and was featured in an earlier press release (eso0905). Notes [1] More information about Wolf-Rayet stars More information ESO, the European Southern Observatory, is the foremost intergovernmental astronomy organisation in Europe and the world's most productive astronomical observatory. It is supported by 14 countries: Austria, Belgium, the Czech Republic, Denmark, France, Finland, Germany, Italy, the Netherlands, Portugal, Spain, Sweden, Switzerland and the United Kingdom. ESO carries out an ambitious programme focused on the design, construction and operation of powerful ground-based observing facilities enabling astronomers to make important scientific discoveries. ESO also plays a leading role in promoting and organising cooperation in astronomical research. ESO operates three unique world-class observing sites in Chile: La Silla, Paranal and Chajnantor. At Paranal, ESO operates the Very Large Telescope, the world's most advanced visible-light astronomical observatory and VISTA, the world's largest survey telescope. ESO is the European partner of a revolutionary astronomical telescope ALMA, the largest astronomical project in existence. ESO is currently planning a 42-metre European Extremely Large optical/near-infrared Telescope, the E-ELT, which will become "the world's biggest eye on the sky".

Fluorine in the solar neighborhood: Chemical evolution models

NASA Astrophysics Data System (ADS)

Spitoni, E.; Matteucci, F.; Jönsson, H.; Ryde, N.; Romano, D.

2018-04-01

Context. In light of new observational data related to fluorine abundances in solar neighborhood stars, we present chemical evolution models testing various fluorine nucleosynthesis prescriptions with the aim to best fit those new data. Aim. We consider chemical evolution models in the solar neighborhood testing various nucleosynthesis prescriptions for fluorine production with the aim of reproducing the observed abundance ratios [F/O] versus [O/H] and [F/Fe] versus [Fe/H]. We study in detail the effects of various stellar yields on fluorine production. Methods: We adopted two chemical evolution models: the classical two-infall model, which follows the chemical evolution of halo-thick disk and thin disk phases; and the one-infall model, which is designed only for thin disk evolution. We tested the effects on the predicted fluorine abundance ratios of various nucleosynthesis yield sources, that is, asymptotic giant branch (AGB) stars, Wolf-Rayet (W-R) stars, Type II and Type Ia supernovae, and novae. Results: The fluorine production is dominated by AGB stars but the W-R stars are required to reproduce the trend of the observed data in the solar neighborhood with our chemical evolution models. In particular, the best model both for the two-infall and one-infall cases requires an increase by a factor of 2 of the W-R yields. We also show that the novae, even if their yields are still uncertain, could help to better reproduce the secondary behavior of F in the [F/O] versus [O/H] relation. Conclusions: The inclusion of the fluorine production by W-R stars seems to be essential to reproduce the new observed ratio [F/O] versus [O/H] in the solar neighborhood. Moreover, the inclusion of novae helps to reproduce the observed fluorine secondary behavior substantially.

LM1-64: a Newly Reported Lmc-Pn with WR Nucleus

NASA Astrophysics Data System (ADS)

Pena, M.; Olguin, L.; Ruiz, M. T.; Torres-Peimbert, S.

1993-05-01

The object LM1-64 was reported by Lindsay & Mullan (1963, Irish Astron. J., 5, 51) as a probable PN in the LMC. Optical and UV spectra taken by us confirm that suggestion. LM1-64 is a high excitation planetary nebulae which shows evidence of having a WC central star. Broad stellar emission at lambda 4650 is detected in the optical spectrum obtained with the CTIO 4m telescope, in 1989. A UV spectrum in the range from 1200 Angstroms to 2000 Angstroms was obtained with IUE in 1990. We have measured all the emission line fluxes available and determined values for the physical conditions and chemical abundances of the nebular ionized gas. The derived values are T(OIII) = 14000K, log He/H = 11.05, log C/H = 9.48, log O/H = 8.55 and log Ne/H = 7.94. LM1-64 shows a large C enhancement in the envelope as result of the central star activity, while He, O and Ne are comparable to the average values reported for the LMC-PNe (Monk, Barlow & Clegg, 1988, MNRAS, 234, 583). We have estimated the He II Zanstra temperature of the central star to be ~ 80,000 K. This temperature is much higher than the values reported for the known LMC-PNe with WR nucleus that Monk et al. have classified as W4 to W8. The only other high temperature WR nucleus in a LMC-PN is N66 which recently showed evidence of undergoing a WR episode (Torres-Peimbert, Ruiz, Peimbert & Pe\\ na, 1993, IAU Symp. 155, eds. A. Acker & R. Weinberger, in press).

X-ray emission from the Wolf-Rayet bubble NGC 6888. I. Chandra ACIS-S observations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Toalá, J. A.; Guerrero, M. A.; Gruendl, R. A.

We analyze Chandra observations of the Wolf-Rayet (W-R) bubble NGC 6888. This W-R bubble presents similar spectral and morphological X-ray characteristics to those of S 308, the only other W-R bubble also showing X-ray emission. The observed spectrum is soft, peaking at the N VII line emission at 0.5 keV, with additional line emission at 0.7-0.9 keV and a weak tail of harder emission up to ∼1.5 keV. This spectrum can be described by a two-temperature optically thin plasma emission model (T {sub 1} ∼ 1.4 × 10{sup 6} K, T {sub 2} ∼ 7.4 × 10{sup 6} K). Wemore » confirm the results of previous X-ray observations that no noticeable temperature variations are detected in the nebula. The X-ray-emitting plasma is distributed in three apparent morphological components: two caps along the tips of the major axis and an extra contribution toward the northwest blowout not reported in previous analyses of the X-ray emission toward this W-R nebula. Using the plasma model fits of the Chandra ACIS spectra for the physical properties of the hot gas and the ROSAT PSPC image to account for the incomplete coverage of Chandra observations, we estimate a luminosity of L {sub X} = (7.7 ± 0.1) ×10{sup 33} erg s{sup –1} for NGC 6888 at a distance of 1.26 kpc. The average rms electron density of the X-ray-emitting gas is ≳ 0.4 cm{sup –3} for a total mass ≳ 1.2 M {sub ☉}.« less

Implications of the Low Binary Black Hole Aligned Spins Observed by LIGO

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hotokezaka, Kenta; Piran, Tsvi

We explore the implications of the low-spin components along the orbital axis observed in an Advanced LIGO O1 run on binary black hole (BBH) merger scenarios in which the merging BBHs have evolved from field binaries. The coalescence time determines the initial orbital separation of BBHs. This, in turn, determines whether the stars are synchronized before collapse, and hence determines their projected spins. Short coalescence times imply synchronization and large spins. Among known stellar objects, Wolf–Rayet (WR) stars seem to be the only progenitors consistent with the low aligned spins observed in LIGO’s O1, provided that the orbital axis maintainsmore » its direction during the collapse. We calculate the spin distribution of BBH mergers in the local universe, and its redshift evolution for WR progenitors. Assuming that the BBH formation rate peaks around a redshift of ∼2–3, we show that BBH mergers in the local universe are dominated by low-spin events. The high-spin population starts to dominate at a redshift of ∼0.5–1.5. WR stars are also progenitors of long gamma-ray bursts that take place at a comparable rate to BBH mergers. We discuss the possible connection between the two phenomena. Additionally, we show that hypothetical Population III star progenitors are also possible. Although WR and Population III progenitors are consistent with the current data, both models predict a non-vanishing fraction of high positive values of the BBHs’ aligned spin. If those are not detected within the coming LIGO/Virgo runs, it will be unlikely that the observed BBHs formed via field binaries.« less

Seated limits-of-stability of athletes with disabilities with regard to competitive levels and sport classification.

PubMed

Santos, P B R; Vigário, P S; Mainenti, M R M; Ferreira, A S; Lemos, T

2017-12-01

In this study, we asked whether wheelchair rugby (WR) classification and competitive level influence trunk function of athletes with disabilities, in terms of seated limits-of-stability (LoS). Twenty-eight athletes were recruited from international- and national-level WR teams, with each group exhibiting marked differences in years of sports practice and training volume. Athletes were also distributed into three groups according their classification: low-point (0.5-1.5-point); mid-point (2.0-2.5-point); and high-point (3.0-3.5-point). Athletes were asked to sit on a force platform and to lean the body as far as possible in eight predefined directions. Center of pressure (COP) coordinates were calculated from the ground reaction forces acquired with the force platform. LoS were computed as the area of ellipse adjusted to maximal COP excursion achieved for the eight directions. ANOVAs reveal that LoS were not different when international- and national-level players were compared (P=.744). Nevertheless, LoS were larger in players from the high-point group than from the low-point group (P=.028), with the mid-point group being not different from both (P>.194). In summary, (i) competitive level does not impact LoS measures and (ii) LoS are remarkably distinct when comparing both extremes of the WR classification range. Our results suggest that, as a training-resistant measure, LoS could be a valid assessment of trunk impairment, potentially contributing to the development of an evidence-based WR classification. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Radioprotective effects of Sipunculus nudus L. polysaccharide combined with WR-2721, rhIL-11 and rhG-CSF on radiation-injured mice

PubMed Central

Jiang, Shuqi; Shen, Xianrong; Liu, Yuming; He, Ying; Jiang, Dingwen; Chen, Wei

2015-01-01

This study investigated the radioprotective effect of Sipunculus nudus L. polysaccharide (SNP) in combination with WR-2721, rhIL-11 and rhG-CSF on irradiated mice. A total of 70 Imprinting Control Region (ICR) mice were divided into seven groups: the control group, the model group and five administration groups. All groups, except the control group, were exposed to a 5 Gy 60Co γ-ray beam. Blood parameters [including white blood cell (WBC), red blood cell (RBC) and platelet counts and hemoglobin level] were assessed three days before irradiation, and the on the 3rd, 7th and 14th days after irradiation. Spleen, thymus and testicular indices, DNA contents of bone marrow cells, bone marrow nucleated cells, sperm counts, superoxide dismutase (SOD), malondialdehyde (MDA), testosterone and estradiol levels in the serum were assessed on the 14th day after irradiation. The combined administration of SNP, WR-2721, rhIL-11 and rhG-CSF exerted synergistic recovery effects on peripheral blood WBC, RBC and platelet counts and hemoglobin levels in irradiated mice, and synergistic promotion effects on spleen, thymus, testicle, bone marrow nucleated cells and sperm counts in irradiated mice. The synergistic administration increased the serum SOD activities and serum testosterone content of irradiated mice, but synergy decreased the content of serum MDA and estradiol in irradiated mice. These results suggest that the combined administration of SNP, WR-2721, rhIL-11 and rhG-CSF should increase the efficacy of these drugs for acute radiation sickness, protect immunity, hematopoiesis and the reproductive organs of irradiated-damaged mice, and improve oxidation resistance in the body. PMID:25852150

Search for third-generation scalar leptoquarks and heavy right-handed neutrinos in final states with two tau leptons and two jets in proton-proton collisions at $$ \\sqrt{s}=13 $$ TeV

DOE PAGES

Sirunyan, A. M.; Tumasyan, A.; Adam, W.; ...

2017-07-26

A search is performed for third-generation scalar leptoquarks and heavy right-handed neutrinos in events containing one electron or muon, one hadronically decaying τ lepton, and at least two jets, using amore » $$ \\sqrt{s}=13 $$ TeV pp collision data sample corresponding to an integrated luminosity of 12.9 fb$$^{-1}$$ collected with the CMS detector at the LHC in 2016. The number of observed events is found to be in agreement with the standard model prediction. A limit is set at 95% confidence level on the product of the leptoquark pair production cross section and β$$^{2}$$, where β is the branching fraction of leptoquark decay to a τ lepton and a bottom quark. Assuming β = 1, third-generation leptoquarks with masses below 850 GeV are excluded at 95% confidence level. An additional search based on the same event topology involves heavy right-handed neutrinos, N$$_{R}$$, and right-handed W bosons, W$$_{R}$$, arising in a left-right symmetric extension of the standard model. In this search, W$$_{R}$$ bosons are assumed to decay to a tau lepton and N$$_{R}$$ followed by the decay of the N$$_{R}$$ to a tau lepton and an off-shell W$$_{R}$$ boson. Assuming the mass of the right-handed neutrino to be half of the mass of the right-handed W boson, W$$_{R}$$ boson masses below 2.9 TeV are excluded at 95% confidence level. Lastly, these results improve on the limits from previous searches for third-generation leptoquarks and heavy right-handed neutrinos with τ leptons in the final state.« less

Search for third-generation scalar leptoquarks and heavy right-handed neutrinos in final states with two tau leptons and two jets in proton-proton collisions at $$ \\sqrt{s}=13 $$ TeV

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sirunyan, A. M.; Tumasyan, A.; Adam, W.

A search is performed for third-generation scalar leptoquarks and heavy right-handed neutrinos in events containing one electron or muon, one hadronically decaying τ lepton, and at least two jets, using amore » $$ \\sqrt{s}=13 $$ TeV pp collision data sample corresponding to an integrated luminosity of 12.9 fb$$^{-1}$$ collected with the CMS detector at the LHC in 2016. The number of observed events is found to be in agreement with the standard model prediction. A limit is set at 95% confidence level on the product of the leptoquark pair production cross section and β$$^{2}$$, where β is the branching fraction of leptoquark decay to a τ lepton and a bottom quark. Assuming β = 1, third-generation leptoquarks with masses below 850 GeV are excluded at 95% confidence level. An additional search based on the same event topology involves heavy right-handed neutrinos, N$$_{R}$$, and right-handed W bosons, W$$_{R}$$, arising in a left-right symmetric extension of the standard model. In this search, W$$_{R}$$ bosons are assumed to decay to a tau lepton and N$$_{R}$$ followed by the decay of the N$$_{R}$$ to a tau lepton and an off-shell W$$_{R}$$ boson. Assuming the mass of the right-handed neutrino to be half of the mass of the right-handed W boson, W$$_{R}$$ boson masses below 2.9 TeV are excluded at 95% confidence level. Lastly, these results improve on the limits from previous searches for third-generation leptoquarks and heavy right-handed neutrinos with τ leptons in the final state.« less

Reduction of extinction and reinstatement of cocaine seeking by wheel running in female rats.

PubMed

Zlebnik, Natalie E; Anker, Justin J; Gliddon, Luke A; Carroll, Marilyn E

2010-03-01

Previous work has shown that wheel running reduced the maintenance of cocaine self-administration in rats. In the present study, the effect of wheel running on extinction and reinstatement of cocaine seeking was examined. Female rats were trained to run in a wheel during 6-h sessions, and they were then catheterized and placed in an operant conditioning chamber where they did not have access to the wheel but were allowed to self-administer iv cocaine. Subsequently, rats were divided into four groups and were tested on the extinction and reinstatement of cocaine seeking while they had varying access to a wheel in an adjoining compartment. The four groups were assigned to the following wheel access conditions: (1) wheel running during extinction and reinstatement (WER), (2) wheel running during extinction and a locked wheel during reinstatement (WE), (3) locked wheel during extinction and wheel running during reinstatement (WR), and (4) locked wheel during extinction and reinstatement (WL). WE and WR were retested later to examine the effect of one session of wheel access on cocaine-primed reinstatement. There were no group differences in wheel revolutions, in rate of acquisition of cocaine self-administration, or in responding during maintenance when there was no wheel access. However, during extinction, WE and WER responded less than WR and WL. WR and WER had lower cocaine-primed reinstatement than WE and WL. One session of wheel exposure in WE also suppressed cocaine-primed reinstatement. Wheel running immediately and effectively reduced cocaine-seeking behavior, but concurrent access to running was necessary. Thus, exercise is a useful and self-sustaining intervention to reduce cocaine-seeking behavior.

Relevance of I-BMIPP delayed scintigraphic imaging for patients with angina pectoris - a pilot study.

PubMed

Koyama, Kohei; Akashi, Yoshihiro J; Kida, Keisuke; Suzuki, Kengo; Ishibashi, Yuki; Musha, Haruki; Banach, Maciej

2011-06-01

The study was designed to clarify the role of (123)I-β-methyl-iodophenylpentadecanoic acid ((123)I-BMIPP) in the evaluation of myocardial fatty acid metabolism in patients with stable angina pectoris (AP) before and after percutaneous coronary intervention (PCI). TEN CONTROLS (MEAN AGE: 70.4 ±10.5 years) and 12 patients with AP (mean age: 67.4 ±11.6 years) and single vessel coronary artery disease participated in the radionuclide cardiac study. Scintigraphic images were acquired at 30 min and at 4 h after (123)I-BMIPP injection to determine early and delayed BMIPP uptake, respectively. The heart-to-mediastinum (H/M) ratio and the washout rate (WR) were calculated from the planar images. All patients underwent scintigraphy one day before PCI and again 1 month after successful PCI. NO SIGNIFICANT DIFFERENCES IN THE EARLY OR DELAYED H/M RATIOS WERE OBSERVED BETWEEN THE PATIENTS AND THE CONTROLS BEFORE PCI (EARLY: 2.70 ±0.36 vs. 2.73 ±0.57; delayed: 2.26 ±0.33 vs. 2.40 ±0.43; p > 0.2 for both). The early and delayed H/M ratios remained unchanged with the comparison with before PCI (early: 2.72 ±0.27, delayed: 2.23 ±0.22; p > 0.2 for both). The global WR before PCI was significantly higher in the patients than in the control group (36.7 ±9.3%, vs. 28.1 ±8.2%, p = 0.02). However, the WR after PCI did not significantly differ between the patients and the controls (34.3 ±7.8% vs. 28.1 ±8.2%, p = 0.1). These data may suggest that the WR of (123)I-BMIPP determined from the planar images enhances the presence of myocardial ischaemia.

Pinwheels in the sky, with dust: 3D modelling of the Wolf-Rayet 98a environment

NASA Astrophysics Data System (ADS)

Hendrix, Tom; Keppens, Rony; van Marle, Allard Jan; Camps, Peter; Baes, Maarten; Meliani, Zakaria

2016-08-01

The Wolf-Rayet 98a (WR 98a) system is a prime target for interferometric surveys, since its identification as a `rotating pinwheel nebulae', where infrared images display a spiral dust lane revolving with a 1.4 yr periodicity. WR 98a hosts a WC9+OB star, and the presence of dust is puzzling given the extreme luminosities of Wolf-Rayet stars. We present 3D hydrodynamic models for WR 98a, where dust creation and redistribution are self-consistently incorporated. Our grid-adaptive simulations resolve details in the wind collision region at scales below one percent of the orbital separation (˜4 au), while simulating up to 1300 au. We cover several orbital periods under conditions where the gas component alone behaves adiabatic, or is subject to effective radiative cooling. In the adiabatic case, mixing between stellar winds is effective in a well-defined spiral pattern, where optimal conditions for dust creation are met. When radiative cooling is incorporated, the interaction gets dominated by thermal instabilities along the wind collision region, and dust concentrates in clumps and filaments in a volume-filling fashion, so WR 98a must obey close to adiabatic evolutions to demonstrate the rotating pinwheel structure. We mimic Keck, ALMA or future E-ELT observations and confront photometric long-term monitoring. We predict an asymmetry in the dust distribution between leading and trailing edge of the spiral, show that ALMA and E-ELT would be able to detect fine-structure in the spiral indicative of Kelvin-Helmholtz development, and confirm the variation in photometry due to the orientation. Historic Keck images are reproduced, but their resolution is insufficient to detect the details we predict.

Advanced designs for non-imaging submillimeter-wave Winston cone concentrators

NASA Astrophysics Data System (ADS)

Nelson, A. O.; Grossman, E. N.

2014-05-01

We describe the design and simulation of several non-imaging concentrators designed to couple submillimeter wavelength radiation from free space into highly overmoded, rectangular, WR-10 waveguide. Previous designs are altered to improve the uniformity of efficiency rather than the efficiency itself. The concentrators are intended for use as adapters between instruments using overmoded WR-10 waveguide as input or output and sources propagating through free space. Previous simulation and measurement have shown that the angular response is primarily determined by the Winston cone and is well predicted by geometric optics theory while the efficiencies are primarily determined by the transition section. Additionally, previous work has shown insensitivity to polarization, orientation and beam size. Several separate concentrator designs are studied, all of which use a Winston cone (also known as a compound parabolic concentrator) with an input diameter ranging from 4 mm to 16 mm, and "throat" diameters of less than 0.5 mm to 4 mm as the initial interface. The use of various length adiabatic circular-to-rectangular transition sections is investigated, along with the effect of an additional, 25 mm waveguide section designed to model the internal waveguide of the power meter. Adapters without a transition section and a rectangular Winston cone throat aperture and double cone configurations are also studied. Adapters are analyzed in simulation for consistent efficiency across the opening aperture.

Tracing WR wind structures by using the orbiting companion in the 29d WC8d + O8-9IV binary CV Ser

NASA Astrophysics Data System (ADS)

David-Uraz, Alexandre; Moffat, Anthony F. J.; Chené, André Nicolas; Lange, Nicholas

2011-01-01

We have obtained continuous, high-precision, broadband visible photometry from the MOST satellite of CV Ser over more than a full orbit in order to link the small-scale light-curve variations to extinction due to wind structures in the WR component, thus permitting us to trace these structures. The light-curve presented unexpected characteristics, in particular eclipses with a varying depth. Parallel optical spectroscopy from the Mont Megantic Observatory and Dominion Astrophysical Observatory was obtained to refine the orbital and wind-collision parameters, as well as to reveal line emission from clumps.

X-ray emission from the Wolf-Rayet bubble NGC 6888 - II. XMM-Newton EPIC observations

NASA Astrophysics Data System (ADS)

Toalá, J. A.; Guerrero, M. A.; Chu, Y.-H.; Arthur, S. J.; Tafoya, D.; Gruendl, R. A.

2016-03-01

We present deep XMM-Newton European Photon Imaging Camera observations of the Wolf-Rayet (WR) bubble NGC 6888 around the star WR 136. The complete X-ray mapping of the nebula confirms the distribution of the hot gas in three maxima spatially associated with the caps and north-west blowout hinted at by previous Chandra observations. The global X-ray emission is well described by a two-temperature optically thin plasma model (T1 = 1.4 × 106 K, T2 = 8.2 × 106 K) with a luminosity of LX = 7.8 × 1033 erg s-1 in the 0.3-1.5 keV energy range. The rms electron density of the X-ray-emitting gas is estimated to be ne = 0.4 cm-3. The high-quality observations presented here reveal spectral variations within different regions in NGC 6888, which allowed us for the first time to detect temperature and/or nitrogen abundance inhomogeneities in the hot gas inside a WR nebula. One possible explanation for such spectral variations is that the mixing of material from the outer nebula into the hot bubble is less efficient around the caps than in other nebular regions.

Blue bubble in Carina

NASA Image and Video Library

2016-02-22

Sparkling at the centre of this beautiful NASA/ESA Hubble Space Telescope image is a Wolf–Rayet star known as WR 31a, located about 30 000 light-years away in the constellation of Carina (The Keel). The distinctive blue bubble appearing to encircle WR 31a, and its uncatalogued stellar sidekick, is a Wolf–Rayet nebula — an interstellar cloud of dust, hydrogen, helium and other gases. Created when speedy stellar winds interact with the outer layers of hydrogen ejected by Wolf–Rayet stars, these nebulae are frequently ring-shaped or spherical. The bubble — estimated to have formed around 20 000 years ago — is expanding at a rate of around 220 000 kilometres per hour! Unfortunately, the lifecycle of a Wolf–Rayet star is only a few hundred thousand years — the blink of an eye in cosmic terms. Despite beginning life with a mass at least 20 times that of the Sun, Wolf–Rayet stars typically lose half their mass in less than 100 000 years. And WR 31a is no exception to this case. It will, therefore, eventually end its life as a spectacular supernova, and the stellar material expelled from its explosion will later nourish a new generation of stars and planets.

Astronomy in Denver: Spectropolarimetric Observations of 5 Wolf-Rayet Binary Stars with SALT/RSS

NASA Astrophysics Data System (ADS)

Fullard, Andrew; Ansary, Zyed; Azancot Luchtan, Daniel; Gallegos, Hunter; Luepker, Martin; Hoffman, Jennifer L.; Nordsieck, Kenneth H.; SALT observation team

2018-06-01

Mass loss from massive stars is an important yet poorly understood factor in shaping their evolution. Wolf-Rayet (WR) stars are of particular interest due to their stellar winds, which create large regions of circumstellar material (CSM). They are also supernova and possible gamma-ray burst (GRB) progenitors. Like other massive stars, WR stars often occur in binaries, where interaction can affect their mass loss rates and provide the rapid rotation thought to be required for GRB production. The diagnostic tool of spectropolarimetry, along with the potentially eclipsing nature of a binary system, helps us to better characterize the CSM created by the stars’ colliding winds. Thus, we can determine mass loss rates and infer rapid rotation. We present spectropolarimetric results for five WR+O eclipsing binary systems, obtained with the Robert Stobie Spectrograph at the South African Large Telescope, between April 2017 and April 2018. The data allow us to map both continuum and emission line polarization variations with phase, which constrains where different CSM components scatter light in the systems. We discuss our initial findings and interpretations of the polarimetric variability in each binary system, and compare the systems.

Hypolipidemic effect of MeOH extract of Bambusae Caulis in Taeniam in hyperlipidemia induced by Triton WR-1339 and high cholesterol diet in rats.

PubMed

Ham, Inhye; Yang, Gabsik; Lee, Jaejun; Lee, Kyung-Jin; Choi, Ho-Young

2009-01-01

Hyperlipidemia has been implicated in atherosclerosis which is the leading cause of death among world population and resulting from lipid metabolic changes is a major cause of atherosclerosis. Bambusae Caulis in Taeniam belongs to Bambusaceae is the stem of Phyllostachys nigra (Lodd.) Munro var. henonis (Bean) Stapf of Phyllostachys bambusoides Siebold et Zuccarini, the perennial evergreen tree. The green middle layer of stem is dried in string-shape I shadow after the bark had been removed. In this study, the effects of middle layer of PN, PB, PP, and BCT on rat with hyperlipidemia, induced by Triton WR-1339 and high cholesterol diet were investigated. We measured plasma levels of triglyceride, total cholesterol, low-density lipoprotein (LDL)-cholesterol, and high-density lipoprotein (HDL)-cholesterol as measure of its hyperlipidemic effects. As a result, all of the Bambusae Caulis in Taeniam was reduced total cholesterol, LDL. Inhibition rate on LDL-oxidation, hACAT-1, and hACAT-2 was increased dose-dependently. Therefore all of the Bambusae Caulis in Taeniam is a good candidate for the treatment on Triton WR-1339 and high cholesterol diet-induced blood circulatory disorders, obesity, and hyperlipidemia.

Measurements by a Vector Network Analyzer at 325 to 508 GHz

NASA Technical Reports Server (NTRS)

Fung, King Man; Samoska, Lorene; Chattopadhyay, Goutam; Gaier, Todd; Kangaslahti, Pekka; Pukala, David; Lau, Yuenie; Oleson, Charles; Denning, Anthony

2008-01-01

Recent experiments were performed in which return loss and insertion loss of waveguide test assemblies in the frequency range from 325 to 508 GHz were measured by use of a swept-frequency two-port vector network analyzer (VNA) test set. The experiments were part of a continuing effort to develop means of characterizing passive and active electronic components and systems operating at ever increasing frequencies. The waveguide test assemblies comprised WR-2.2 end sections collinear with WR-3.3 middle sections. The test set, assembled from commercially available components, included a 50-GHz VNA scattering- parameter test set and external signal synthesizers, augmented with recently developed frequency extenders, and further augmented with attenuators and amplifiers as needed to adjust radiofrequency and intermediate-frequency power levels between the aforementioned components. The tests included line-reflect-line calibration procedures, using WR-2.2 waveguide shims as the "line" standards and waveguide flange short circuits as the "reflect" standards. Calibrated dynamic ranges somewhat greater than about 20 dB for return loss and 35 dB for insertion loss were achieved. The measurement data of the test assemblies were found to substantially agree with results of computational simulations.

High resolution distributed time-to-digital converter (TDC) in a White Rabbit network

NASA Astrophysics Data System (ADS)

Pan, Weibin; Gong, Guanghua; Du, Qiang; Li, Hongming; Li, Jianmin

2014-02-01

The Large High Altitude Air Shower Observatory (LHAASO) project consists of a complex detector array with over 6000 detector nodes spreading over 1.2 km2 areas. The arrival times of shower particles are captured by time-to-digital converters (TDCs) in the detectors' frontend electronics, the arrival direction of the high energy cosmic ray are then to be reconstructed from the space-time information of all detector nodes. To guarantee the angular resolution of 0.5°, a time synchronization of 500 ps (RMS) accuracy and 100 ps precision must be achieved among all TDC nodes. A technology enhancing Gigabit Ethernet, called the White Rabbit (WR), has shown the capability of delivering sub-nanosecond accuracy and picoseconds precision of synchronization over the standard data packet transfer. In this paper we demonstrate a distributed TDC prototype system combining the FPGA based TDC and the WR technology. With the time synchronization and data transfer services from a compact WR node, separate FPGA-TDC nodes can be combined to provide uniform time measurement information for correlated events. The design detail and test performance will be described in the paper.

Low oxytocin levels are related to alexithymia in anorexia nervosa.

PubMed

Schmelkin, Cindy; Plessow, Franziska; Thomas, Jennifer J; Gray, Emily K; Marengi, Dean A; Pulumo, Reitumetse; Silva, Lisseth; Miller, Karen K; Hadjikhani, Nouchine; Franko, Debra L; Eddy, Kamryn T; Lawson, Elizabeth A

2017-11-01

Anorexia nervosa is associated with social-emotional functioning deficits and low levels of the social neurohormone oxytocin, even after weight gain. The relationship between low oxytocin levels and social-emotional functioning impairment has not been studied. We performed a cross-sectional study of 79 women (19 who were less than 85% of ideal body weight [IBW] with anorexia nervosa [AN], 26 who were 90-120% IBW with a history of AN [AN-WR], and 34 who were 90-120% IBW with no eating disorder history [H]). We administered the Eating Disorder Examination-Questionnaire (EDE-Q), Leibowitz Social Anxiety Scale-Self Report (LSAS-SR), Dimensional Assessment of Personality Pathology-Basic Questionnaire (DAPP-BQ; suspiciousness and insecure attachment subscales), and the Toronto Alexithymia Scale (TAS-20). We also analyzed fasting serum oxytocin levels. Most measures of social-emotional functioning showed impairment in women with AN and AN-WR compared to H. Oxytocin levels were low in AN-WR compared to H. Across groups, low oxytocin levels were associated with difficulty identifying feelings (r = -.45, p = .008) and overall alexithymia (r = -.34, p = .0489). We speculate that low oxytocin levels may contribute to alexithymia in women with anorexia nervosa. © 2017 Wiley Periodicals, Inc.

Mid-Infrared Spectrally-Dispersed Visibilities of Massive Stars Observed with the MIDI Instrument on the VLTI

NASA Astrophysics Data System (ADS)

Wallace, D. J.; Rajagopal, J.; Barry, R.; Richardson, L. J.; Lopez, B.; Chesneau, O.; Danchi, W. C.

The mechanism driving dust production in massive stars remains somewhat mysterious. However, recent aperture-masking and interferometric observations of late-type WC Wolf-Rayet (WR) stars strongly support the theory that dust formation in these objects is a result of colliding winds in binaries. Consistent with this theory, there is also evidence that suggests the prototypical Luminous Blue Variable (LBV) star, Eta Carinae, is a binary. To explore and quantify this possible explanation, we have conducted a high resolution interferometric survey of late-type massive stars utilizing the VLTI, Keck, and IOTA interferometers. We present here the motivation for this study as well as the first results from the MIDI instrument on the VLTI. (Details of the Keck Interferometer and IOTA interferometer observations are discussed in this workshop by Rajagopal et al.). Our VLTI study is aimed primarily at resolving and characterizing the dust around the WC9 star WR 85a and the LBV WR 122, both dust-producing but at different phases of massive star evolution. The pectrally-dispersed visibilities obtained with the MIDI observations will provide the first steps towards answering many outstanding issues in our understanding of this critical phase of massive star evolution

Helium Star Models with Optically Thick Winds: Implications for the Internal Structures and Mass-loss Rates of Wolf–Rayet Stars

NASA Astrophysics Data System (ADS)

Nakauchi, Daisuke; Saio, Hideyuki

2018-01-01

We construct helium (He) star models with optically thick winds and compare them with the properties of Galactic Wolf–Rayet (WR) stars. Hydrostatic He-core solutions are connected smoothly to trans-sonic wind solutions that satisfy the regularity conditions at the sonic point. Velocity structures in the supersonic parts are assumed by a simple β-type law. By constructing a center-to-surface structure, a mass-loss rate {\\dot{M}}{{w}} can be obtained as an eigenvalue of the equations. Sonic points appear at temperatures ≈ (1.8{--}2.8)× {10}5 {{K}} below the Fe-group opacity peak, where the radiation force becomes comparable to the local gravity. Photospheres are located at radii 3–10 times larger than sonic points. The obtained mass-loss rates are comparable to those of WR stars. Our {\\dot{M}}{{w}}–luminosity relation agrees well with the relation recently obtained by Gräfener et al. Photospheric temperatures of WR stars tend to be cooler than our predictions. We discuss the effects of stellar evolution, detailed radiation transfer, and wind clumping, which are ignored in this paper.

Cuff inflation-supplemented laryngoscope-guided nasal intubation: a comparison of three endotracheal tubes.

PubMed

Kumar, Rakesh; Gupta, Ekta; Kumar, Sunil; Rani Sharma, Kavita; Rani Gupta, Neera

2013-03-01

Softer endotracheal (ET) tubes are more difficult to navigate in the oropharynx than the stiffer polyvinyl chloride (PVC) tubes during nasotracheal intubation (NTI). Cuff inflation has been used to guide PVC tubes into the laryngeal inlet during blind NTI, but it has not been tested when performing NTI under direct laryngoscopic guidance. We assessed the role of cuff inflation in improving oropharyngeal navigation of 3 ET tubes of varying stiffness during direct laryngoscope-guided NTI. Simultaneously, we also assessed and compared the nasotracheal navigability and incidence of nasal injury with these ET tubes during cuff inflation-supplemented, laryngoscope-guided NTI. One hundred sixty-two adults were randomized to undergo NTI with either a conventional PVC (n = 54), wire reinforced (WR; n = 54) or a silicone-tipped WR (SWR; n = 54) ET tube. Ease of insertion of these tubes was assessed during passage from nose into oropharynx, from oropharynx into laryngeal inlet aided by cuff inflation if needed, and from laryngeal inlet into trachea. Nasal morbidity was assessed by a blinded observer. All ET tubes could be inserted into the trachea. Seventy-one of 162 ET tubes could be inserted from the oropharynx into the laryngeal inlet without cuff inflation. Eighty-six of the remaining 91 tubes that did not enter the laryngeal inlet without cuff inflation could be inserted when using the cuff inflation technique. Thus, a total of 157 ET tubes could be inserted into the laryngeal inlet with cuff inflation (95% confidence interval of difference of proportions between total number of tubes passed [157] and those without cuff inflation [71]: 53% [45%-61%]). The remaining 5 tubes had to be inserted with the help of Magill forceps. The incidence of epistaxis was lowest with the SWR tube (difference of proportions [95% confidence interval] SWR versus PVC 27% [8%-45%]; SWR versus WR 20% [1%-38%]; WR versus PVC 7% [-12% to 26%]). The cuff inflation technique consistently improved the oropharyngeal insertion of the 3 ET tubes of varying stiffness during direct laryngoscope-guided NTI. Supplemented with the cuff inflation technique, the SWR ET tube seems to be better than the PVC and WR ET tubes in terms of complete nasotracheal navigability and less perioperative nasal injury.

Integral field spectroscopy of M1-67. A Wolf-Rayet nebula with luminous blue variable nebula appearance

NASA Astrophysics Data System (ADS)

Fernández-Martín, A.; Vílchez, J. M.; Pérez-Montero, E.; Candian, A.; Sánchez, S. F.; Martín-Gordón, D.; Riera, A.

2013-06-01

Aims: This work aims to disentangle the morphological, kinematic, and chemical components of the nebula M1-67 to shed light on its process of formation around the central Wolf-Rayet (WR) star WR124. Methods: We have carried out integral field spectroscopy observations over two regions of M1-67, covering most of the nebula in the optical range. Maps of electron density, line ratios, and radial velocity were created to perform a detailed analysis of the two-dimensional structure. We studied the physical and chemical properties by means of integrated spectra selected over the whole nebula. Photoionization models were performed to confirm the empirical chemical results theoretically. In addition, we obtained and analysed infrared spectroscopic data and the MIPS 24 μm image of M1-67 from Spitzer. Results: We find that the ionized gas of M1-67 is condensed in knots aligned in a preferred axis along the NE-SW direction, like a bipolar structure. Both electron density and radial velocity decrease in this direction when moving away from the central star. From the derived electron temperature, Te ~ 8200 K, we have estimated chemical abundances, obtaining that nitrogen appears strongly enriched and oxygen depleted. From the last two results, we infer that this bipolarity is the consequence of an ejection of an evolved stage of WR124 with material processed in the CNO cycle. Furthermore, we find two regions placed outside of the bipolar structure with different spectral and chemical properties. The infrared study has revealed that the bipolar axis is composed of ionized gas with a low ionization degree that is well mixed with warm dust and of a spherical bubble surrounding the ejection at 24 μm. Taking the evolution of a 60 M⊙ star and the temporal scale of the bipolar ejection into account, we propose that the observed gas was ejected during an eruption in the luminous blue variable stage. The star has entered the WR phase recently without apparent signs of interaction between WR-winds and interstellar material. Based on observations collected at the Centro Astronómico Hispano Alemán (CAHA) at Calar Alto, operated jointly by the Max-Planck-Institut für Astronomie and the Instituto de Astrofísica de Andalucía (CSIC).

Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place. Part 19. (Tube Manufacturing Co., Inc.-Voith-Turbo GMBH & Co. KG)

DTIC Science & Technology

1989-01-01

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Toward Detecting the 2175 Å Dust Feature Associated with Strong High-redshift Mg II Absorption Lines

NASA Astrophysics Data System (ADS)

Jiang, Peng; Ge, Jian; Zhou, Hongyan; Wang, Junxian; Wang, Tinggui

2011-05-01

We report detections of 39 2175 Å dust extinction bump candidates associated with strong Mg II absorption lines at z~ 1-1.8 on quasar spectra in Sloan Digital Sky Survey (SDSS) DR3. These strong Mg II absorption line systems are detected among 2951 strong Mg II absorbers with a rest equivalent width Wr λ2796> 1.0 Å at 1.0 < z < 1.86, which is part of a full sample of 7421 strong Mg II absorbers compiled by Prochter et al. The redshift range of the absorbers is chosen to allow the 2175 Å extinction features to be completely covered within the SDSS spectrograph operation wavelength range. An upper limit of the background quasar emission redshift at z = 2.1 is set to prevent the Lyα forest lines from contaminating the sensitive spectral region for the 2175 Å bump measurements. The FM90 parameterization is applied to model the optical/UV extinction curve in the rest frame of Mg II absorbers of the 2175 Å bump candidates. The simulation technique developed by Jiang et al. is used to derive the statistical significance of the candidate 2175 Å bumps. A total of 12 absorbers are detected with 2175 Å bumps at a 5σ level of statistical significance, 10 are detected at a 4σ level, and 17 are detected at a 3σ level. Most of the candidate bumps in this work are similar to the relatively weak 2175 Å bumps observed in the Large Magellanic Cloud LMC2 supershell rather than the strong ones observed in the Milky Way. This sample has greatly increased the total number of 2175 Å extinction bumps measured on SDSS quasar spectra. Follow-up observations may rule out some of the possible false detections and reveal the physical and chemical natures of 2175 Å quasar absorbers.

A comprehensive study of the cool gas content of massive dark matter halos

NASA Astrophysics Data System (ADS)

Gauthier, Jean-Rene

2011-09-01

This thesis is based on the results of an on-going investigation of the cool, T ˜ 104 K, gas present in massive dark matter halos traced by luminous red galaxies (LRGs) at z ˜ 0.5. It consists of three parts. The first part (Chapter 2) presents a series of measurements of the large-scale clustering of MgII lambdalambda 2796,2803 absorbers with respect to a population of LRGs. From the cross-correlation measurements between the absorbers and the galaxies, the mean bias of the dark matter halos in which the absorbers reside is derived. One finds a 1-sigma anti-correlation between mean halo bias and absorber strength W r(2796) that translates into a 1-sigma anti-correlation between mean galaxy mass and Wr(2796). The results indicate that a significant fraction of the MgII absorber population of W r(2796) = 1-1.5A are found in group-size dark matter halos of log Mh < 13.4, whereas absorbers of Wr(2796) > 1.5A are primarily seen in halos of log Mh < 12.7. In the second part of this thesis, a series of constraints on the covering fraction of cool gas are derived in Chapter 3. The results of an on-going spectroscopic follow-up of close LRG-Mg II absorber pairs are presented in Chapter 4. This spectroscopic sample consists of 70 photometrically selected LRGs at physical projected separations rho <˜ 400 kpc/h from a QSO sightline. The moderate-resolution spectra confirm a physical association between the cool gas revealed by the presence of MgII absorption features and the LRG halo in 15 cases. From a pair sample with no prior knowledge of the presence/absence of MgII absorbers, a covering fraction kappa = 0.13+0.05-0.06 is found for Wr(2796) > 0.3A and rho < 400 kpc/h. The third part of this thesis addresses the results of a stellar population synthesis analysis done on stacked spectra of MgII absorbing and non-absorbing LRG subsamples. The main finding of this analysis is that LRGs with or without associated MgII absorbers share similar star formation histories and are best described by old stellar population models (>˜ 1 Gyr). Younger stellar populations (<˜1 Gyr) fail to reproduce their spectra. The primarily old stellar populations in the LRGs indicate that recent starburst driven outflows are unlikely to explain the observed MgII absorbers at large distances from the LRGs. Finally, high-resolution spectra of seven MgII absorbers found in the vicinity of LRGs and associated deep, R-band images of the QSO-LRG fields are presented in Appendix A. These new data are crucial to study the kinematics of the gas and constrain its physical origin.