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Sample records for abstinence violation effect

  1. A Test of the Abstinence Violation Effect.

    ERIC Educational Resources Information Center

    Ruderman, Audrey J.

    According to the abstinence violation effect, highly controlled drinkers tend to overindulge following an initial slip. To investigate this relapse model, 47 male college students, ranging in age from 21 to 46, were assigned either to an unrestrained or a restrained drinker group according to their scores on the Restrained Drinking Scale. Subjects…

  2. Abstinence Violation Effect: Validation of an Attributional Construct with Smoking Cessation.

    ERIC Educational Resources Information Center

    Curry, Susan; And Others

    1987-01-01

    The abstinence violation effect (AVE) proposed in Marlatt and Gordon's model of smoking relapse was operationalized as a combination of internal, stable, and global causal attributions for smoking following the attainment of abstinence from smoking. Smoking cessation program participants who relapsed following a slip reported significantly higher…

  3. Abstinence

    MedlinePlus

    ... opportunity for sperm to fertilize an egg. continue Protection Against STDs Abstinence protects people against STDs. Some STDs spread through oral-genital sex, anal sex, or even intimate skin-to-skin ...

  4. Effectiveness of Abstinence-Only Intervention in Middle School Teens

    ERIC Educational Resources Information Center

    Borawski, Elaine A.; Trapl, Erika S.; Lovegreen, Loren D.; Colabianchi, Natalie; Block, Tonya

    2005-01-01

    Objectives: To examine effectiveness of abstinence-until-marriage curriculum on knowledge, beliefs, efficacy, intentions, and behavior. Methods: Nonrandomized control trial involving 2069 middle school students with a 5-month follow-up. Results: Intervention students reported increases in knowledge and abstinence beliefs, but decreases in…

  5. [Evaluation of educational effects on drug dependence abstinence for convicts].

    PubMed

    Sakurai, Tomoko; Nishikawa, Kyoko; Tanaka, Takanori

    2011-06-01

    The object of this study is to evaluate the educational effects of group work sessions on drug dependence abstinence for convicts in Fukui Prison. Questionnaire surveys were conducted among participants on the first and last session. The results of surveys were analyzed quantitatively. The average ages of 50 respondents were 39 years. 95.9% of them used methamphetamine among drugs and the majority has used drugs for the past 5 years. 93.9% of respondents had no medical treatment histories and 95.8% of them have not used any formal consultations. The survey result before the sessions showed that 75.5% of respondents showed positive stances towards participations on educational group work sessions. The survey after the sessions showed 67.4% of respondents were able to talk their drug problems in group meetings and 87.0% responded that group work sessions were helpful for solving drug problems. Also, 80.0% responded that they can stop using drugs and the percentage dropped by 11.0% from the first session. In terms of the participation in self-help groups after releases from the prison, the majority responded negatively, although 78.0% showed positive responses to using consultation services. The outcomes by means of evaluation scale also showed a significant improvement on denial and no relevant change on interpersonal trusts. This study revealed that it was possible to confirm the effectiveness of drug abstinence education through group work. It is important to consider three points in further studies; 1) cooperation between judicial and medical institutions for introducing consultation and medical treatments among convicts; 2) follow-up programs for reinforcing education on drug abstinence; 3) social welfare services in cooperation with educational effects to prevent repeated offences. PMID:21861335

  6. Comprehensive Sexuality Education or Abstinence-Only Education: Which Is More Effective?

    ERIC Educational Resources Information Center

    Pittman, Vicki; Gahungu, Athanase

    2006-01-01

    The purpose of this study was to examine the difference in effectiveness between comprehensive sexuality abstinence-based education and abstinence-only education. A survey was developed and distributed to over 140 individuals via a variety of sources such as: (1) the researcher's e-mail lists; (2) a group of City Core/City Year volunteers; (3) a…

  7. Effects of Initial Abstinence and Programmed Lapses on the Relative Reinforcing Effects of Cigarette Smoking

    ERIC Educational Resources Information Center

    Chivers, Laura L.; Higgins, Stephen T.; Heil, Sarah H.; Proskin, Rebecca W.; Thomas, Colleen S.

    2008-01-01

    Fifty-eight smokers received abstinence-contingent monetary payments for 1 (n = 15) or 14 (n = 43) days. Those who received contingent payments for 14 days also received 0, 1, or 8 experimenter-delivered cigarette puffs on 5 evenings. The relative reinforcing effects of smoking were assessed in a 3-hr session on the final study day, when…

  8. A Multistudy Analysis of the Effects of Early Cocaine Abstinence on Sleep

    PubMed Central

    Matuskey, D; Pittman, B; Forselius, E; Malison, RT; Morgan, PT

    2010-01-01

    Objective To describe the sleep patterns of early cocaine abstinence in chronic users by polysomnographic and subjective measures. Methods 28 cocaine-dependent participants (ages 24-55) underwent polysomnographic sleep (PSG) recording on the 1st, 2nd and 3rd weeks of abstinence on a research dedicated inpatient facility. Objective measures of total sleep time, total REM time, slow wave sleep, sleep efficiency and a subjective measure (sleep quality) along with demographic data were collected from three different long term research studies over a five year period. Data were reanalyzed to allow greater statistical power for comparisons. Results Progressive weeks of abstinence had main effects on all assessed PSG sleep measures showing decreased total sleep time, REM sleep, stage 1 and 2 sleep, and sleep efficiency; increases in sleep onset and REM latencies and a slight increase in slow-wave sleep time were also present. Total sleep time and slow wave sleep were negatively associated with years of cocaine use. Total sleep time was positively associated with the amount of current ethanol use. Sex differences were found with females having more total REM time and an increase at a near significance level in slow wave sleep. Subjective measures were reported as improving with increasing abstinence over the same time period. Conclusions Chronic cocaine users show a general deterioration in objective sleep measures over a three-week period despite an increase in subjective overall sleep quality providing further evidence for “occult insomnia” during early cocaine abstinence. PMID:21144676

  9. Effects of naltrexone on post-abstinence alcohol drinking in C57BL/6NCRL and DBA/2J mice.

    PubMed

    Tomie, Arthur; Azogu, Idu; Yu, Lei

    2013-07-01

    The present experiment evaluated the effects of naltrexone, a non-selective opioid receptor antagonist, on post-abstinence alcohol drinking in C57BL/6NCRL and DBA/2J male mice. Home cage 2-bottle (alcohol vs. water) free-choice procedures were employed. During the pre-abstinence period, alcohol intake was much lower for the DBA/2J mice relative to the C57BL/6NCRL mice, and this strain difference was observed for groups receiving either 3% or 10% alcohol concentrations. The four-day abstinence period effectively reduced alcohol intakes (i.e., a negative alcohol deprivation effect, negative ADE) in both groups of DBA/2J mice, but had no effect on alcohol intakes in either group of C57BL/6NCRL mice. Both groups trained with 3% alcohol received the second four-day abstinence period, where the effects of acute administration of either naltrexone or saline on post-abstinence alcohol drinking were assessed. Naltrexone was more effective in reducing post-abstinence drinking of 3% alcohol in the DBA/2J mice than in the C57BL/6NCRL mice. In the DBA/2J mice, naltrexone further reduced, relative to saline-injected controls, the low levels of post-abstinence alcohol intake. Thus, the low baseline levels of alcohol drinking in DBA/2J mice were further diminished by the four-day abstinence period (negative ADE), and this suppressed post-abstinence level of alcohol drinking was still further reduced by acute administration of naltrexone. The results indicate that naltrexone is effective in reducing further the low levels of alcohol drinking induced by the negative ADE. PMID:23499782

  10. Effect of Abstinence on Depression, Anxiety, and Quality of Life in Chronic Methamphetamine Users in a Therapeutic Community

    PubMed Central

    Bagheri, Maryam; Mokri, Azarakhsh; Khosravi, Aliakbar; Kabir, Kourosh

    2015-01-01

    Background: During withdrawal, patients experience different symptoms. These symptoms are associated with relapse. Understanding different outcomes of methamphetamine abstinence is useful for finding better treatments for dependence. Objectives: This study aimed to show the effects of abstinence on depression, anxiety, and quality of life in methamphetamine users. Patients and Methods: A prospective quasi-experimental (before and after study) method was used to show the effect of 3 weeks abstinence on depression, anxiety, and quality of life. A convenient sample of addicted people entered into the study and 34 people completed the study. Beck Depression Scale, Cattell Anxiety Inventory and Short Form Health Survey (SF-36) (for assessing quality of life), were used for outcome assessments. Results: The mean depression score after abstinence decreased significantly (P < 0.001). Both hidden and obvious anxiety and total anxiety had a high level at admission and after 3 weeks of abstinence, the mean level of anxiety did not change significantly (P < 0.096). However, the quality of life increased after 3 weeks of abstinence (P < 0.001). Conclusions: Depression and anxiety are prevalent in methamphetamine users. Short-term abstinence improves depression and quality of life but does not improve anxiety in methamphetamine abusers. During follow up of these patients, addressing depression and anxiety is important to achieve better results. PMID:26495258

  11. Effects of DA-Phen, a dopamine-aminoacidic conjugate, on alcohol intake and forced abstinence.

    PubMed

    Sutera, Flavia Maria; De Caro, Viviana; Cannizzaro, Carla; Giannola, Libero Italo; Lavanco, Gianluca; Plescia, Fulvio

    2016-09-01

    The mesolimbic dopamine (DA) system plays a key role in drug reinforcement and is involved in the development of alcohol addiction. Manipulation of the DAergic system represents a promising strategy to control drug-seeking behavior. Previous studies on 2-amino-N-[2-(3,4-dihydroxy-phenyl)-ethyl]-3-phenyl-propionamide (DA-Phen) showed in vivo effects as a DA-ergic modulator. This study was aimed at investigate DA-Phen effects on operant behavior for alcohol seeking behavior, during reinstatement following subsequent periods of alcohol deprivation. For this purpose, male Wistar rats were tested in an operant paradigm of self-administration; behavioral reactivity and anxiety like-behavior during acute abstinence were evaluated. A characterization of DA-Phen CNS targeting by its quantification in the brain was also carried out. Our findings showed that DA-Phen administration was able to reduce relapse in alcohol drinking by 50% and reversed the alterations in behavioral reactivity and emotionality observed during acute abstinence. In conclusion, DA-Phen can reduce reinstatement of alcohol drinking in an operant-drinking paradigm following deprivation periods and reverse abstinence-induced behavioral phenotype. DA-Phen activity seems to be mediated by the modulation of the DAergic transmission. However further studies are needed to characterize DA-Phen pharmacodynamic and pharmacokinetic properties, and its potential therapeutic profile in alcohol addiction. PMID:27155501

  12. Nigerian secondary school adolescents' perspective on abstinence-only sexual education as an effective tool for promotion of sexual health.

    PubMed

    Inyang, Mfrekemfon P; Inyang, Obonganyie P

    2013-01-01

    The success of any type of sexual education programme depends on the knowledge and preparedness for practice by adolescents. A recent study has found that an 'abstinence-only' sexual education programme is effective in reducing sexual activity among adolescents. Knowledge of abstinence-only sexual education and preparedness for practice as an effective tool for promotion of sexual health among Nigerian secondary school adolescents was studied. An analytic descriptive survey design was used for the study. The research population comprised of all public secondary schools in three southern geopolitical zones of the Niger Delta Region of Nigeria. A multistage sampling technique was used to select 2020 senior secondary school (SS1-SS3) students as sample for the study. A partially self-designed and partially adapted questionnaire from an 'abstinence-only versus comprehensive sex education' debate, from debatepedia (http://wiki.idebate.org/), entitled 'Questionnaire on Nigerian Secondary School Adolescents' Perspective on Abstinence-Only Sexual Education (QNSSAPAOSE)' was used in eliciting information from respondents. Hypotheses were formulated and tested. Frequency counts, percentage and Pearson Product Moment Correlation were used in analysing data. A greater proportion of secondary school adolescents in this study lacked knowledge of sexual education. About 80% of the respondents could not define sexual education. The general perspective on abstinence-only sexual education was negative, as revealed by the larger number of respondents who demonstrated unwillingness to practice abstinence-only sexual education. Specifically, of those who responded in favour of abstinence-only sexual education, the youngest group of adolescents (11-13 years) and the male respondents were more likely to accept this type of education than the other groups. Poor knowledge of sexual education could be responsible for unwillingness to practice abstinence-only sexual education. Sexual

  13. Nicotine content and abstinence state have different effects on subjective ratings of positive versus negative reinforcement from smoking

    PubMed Central

    Lindsey, Kimberly P.; Bracken, Bethany K.; MacLean, Robert R.; Ryan, Elizabeth T.; Lukas, Scott E.; Frederick, Blaise deB.

    2012-01-01

    Despite the well-known adverse health consequences of smoking, approximately 20% of US adults smoke tobacco cigarettes. Much of the research on smoking reinforcement and the maintenance of tobacco smoking behavior has focused on nicotine; however, a number of other non-nicotine factors are likely to influence the reinforcing effects of smoked tobacco. A growing number of studies suggest that non-nicotine factors, through many pairings with nicotine, are partially responsible for the reinforcing effect of smoking. Additionally, both clinical studies and preclinical advances in our understanding of nicotinic receptor regulation suggest that abstinence from smoking may influence smoking reinforcement. These experiments were conducted for 2 reasons: to validate a MRI-compatible cigarette smoking device; and to simultaneously investigate the impact of nicotine, smoking-associated conditioned reinforcers, and smoking abstinence state on subjective ratings of smoking reinforcement. Participants smoked nicotine and placebo cigarettes through an fMRI compatible device in an overnight-abstinent state or in a nonabstinent state, after having smoked a cigarette 25 minutes prior. Outcome measures were within-subject changes in physiology and subjective ratings of craving and drug effect during the smoking of nicotine or placebo cigarettes on different days in both abstinence states. Cigarette type (nicotine vs. placebo) had a significant effect on positive subjective ratings of smoking reinforcement (“High”, “Like Drug”, “Feel Drug”; nicotine>placebo). In contrast, abstinence state was found to have significant effects on both positive and negative ratings of smoking reinforcement (“Crave”, “Anxiety”, “Irritability”; abstinence > nonabstinence). Interaction effects between abstinence and nicotine provide clues about the importance of neuroadaptive mechanisms operating in dependence, as well as the impact of conditioned reinforcement on subjective ratings

  14. PROOF-OF-CONCEPT HUMAN LABORATORY STUDY FOR PROTRACTED ABSTINENCE IN ALCOHOL DEPENDENCE: EFFECTS OF GABAPENTIN

    PubMed Central

    Mason, Barbara J.; Light, John M.; Williams, Lauren D.; Drobes, David J.

    2009-01-01

    There is a need for safe medications that can effectively support recovery by treating symptoms of protracted abstinence in alcoholics that may precipitate relapse e.g., craving and disturbances in sleep and mood. This proof-of-concept study reports on the effectiveness of gabapentin 1200 mg for attenuating these symptoms in a non treatment-seeking sample of cue-reactive, alcohol-dependent individuals. Subjects were 33 paid volunteers with current DSM-IV alcohol dependence and a strength of craving rating 1σ or greater for alcohol than water cues. Subjects were randomly assigned to gabapentin or placebo for 1-week and then participated in a within-subjects trial where each was exposed to standardized sets of pleasant, neutral, and unpleasant visual stimuli followed by alcohol or water cues. We found a significant attenuating effect of gabapentin (vs. placebo) on several measures of subjective craving for alcohol as well as for affectively-evoked craving. Gabapentin was also found to significantly improve several measures of sleep quality. Side effects were minimal, and gabapentin effects were not found to resemble any major classes of abused drugs. Results suggest that gabapentin may be effective for treating the protracted abstinence phase in alcohol dependence and, hence, that a randomized clinical trial would be an appropriate next step. The study also suggests the value of cue reactivity studies as proof-of-concept screens for potential anti relapse drugs. PMID:18855801

  15. Effects of abstinence from chronic cocaine self-administration on nonhuman primate dorsal and ventral noradrenergic bundle terminal field structures.

    PubMed

    Smith, Hilary R; Beveridge, Thomas J R; Nader, Michael A; Porrino, Linda J

    2016-06-01

    Repeated exposure to cocaine is known to dysregulate the norepinephrine system, and norepinephrine has also been implicated as having a role in abstinence and withdrawal. The goal of this study was to determine the effects of exposure to cocaine self-administration and subsequent abstinence on regulatory elements of the norepinephrine system in the nonhuman primate brain. Rhesus monkeys self-administered cocaine (0.3 mg/kg/injection, 30 reinforcers/session) under a fixed-interval 3-min schedule of reinforcement for 100 sessions. Animals in the abstinence group then underwent a 30-day period during which no operant responding was conducted, followed by a final session of operant responding. Control animals underwent identical schedules of food reinforcement and abstinence. This duration of cocaine self-administration has been shown previously to increase levels of norepinephrine transporters (NET) in the ventral noradrenergic bundle terminal fields. In contrast, in the current study, abstinence from chronic cocaine self-administration resulted in elevated levels of [(3)H]nisoxetine binding to the NET primarily in dorsal noradrenergic bundle terminal field structures. As compared to food reinforcement, chronic cocaine self-administration resulted in decreased binding of [(3)H]RX821002 to α2-adrenoceptors primarily in limbic-related structures innervated by both dorsal and ventral bundles, as well as elevated binding in the striatum. However, following abstinence from responding for cocaine binding to α2-adrenoceptors was not different than in control animals. These data demonstrate the dynamic nature of the regulation of norepinephrine during cocaine use and abstinence, and provide further evidence that the norepinephrine system should not be overlooked in the search for effective pharmacotherapies for cocaine dependence. PMID:26013302

  16. Effects of fluvoxamine and citalopram in maintaining abstinence in a sample of Italian detoxified alcoholics.

    PubMed

    Angelone, S M; Bellini, L; Di Bella, D; Catalano, M

    1998-01-01

    A 16-week, randomized study was performed to test the efficacy of two selective serotonin reuptake inhibitors (SSRIs) fluvoxamine and citalopram, in decreasing relapse and craving in alcoholics, and to investigate possible differences in their clinical profile. After detoxification, each of the 81 patients (55 males and 26 females) was randomly assigned to one of three groups: 23 subjects did not receive any pharmacological treatment, 25 were treated with fluvoxamine, 150mg/day, and 33 with citalopram, 20 mg/day. All patients received standard cognitive-behavioural therapy. Craving was assessed twice a month using a 10-step scale. Every intake of alcohol was considered a relapse and the subject was taken out of the study. At the end of the study, both the fluvoxamine and citalopram groups showed a statistically higher rate of continuous abstinence (63.6 and 60.7%, respectively) compared to the group without pharmacological treatment (30.4%). Relapse severity did not differ among the three groups. Only citalopram showed a significant effect on craving throughout the study period. This study confirmed the efficacy of SSRIs as an adjunct to psychotherapy to prevent relapse in alcoholics. The relationship between the effects of these SSRIs on abstinence and craving, as well as the differences between their profiles, are discussed. PMID:9566477

  17. Abstinence education*

    PubMed Central

    Zeiler, Alean

    2014-01-01

    The American College of Pediatricians strongly endorses abstinence-until-marriage sex education and recommends adoption by all school systems in lieu of “comprehensive sex education.” This position is based on “the public health principle of primary prevention—risk avoidance in lieu of risk reduction,” upholding the “human right to the highest attainable standard of health” (Freedman 1995). PMID:25473134

  18. Effects of an Internet-Based Voucher Reinforcement Program for Smoking Abstinence: A Feasibility Study

    ERIC Educational Resources Information Center

    Dallery, Jesse; Glenn, Irene M.

    2005-01-01

    The present study tested the feasibility of an Internet-based method to obtain objective evidence of smoking abstinence and to deliver vouchers for evidence of abstinence. Four heavy smokers participated in this 4-week study. Twice daily, participants made video recordings of themselves providing a breath carbon monoxide (CO) sample with a Web…

  19. Brain Activity in Cigarette Smokers Performing a Working Memory Task: Effect of Smoking Abstinence

    PubMed Central

    Xu, Jiansong; Mendrek, Adrianna; Cohen, Mark S.; Monterosso, John; Rodriguez, Paul; Simon, Sara L.; Brody, Arthur; Jarvik, Murray; Domier, Catherine P.; Olmstead, Richard; Ernst, Monique; London, Edythe D.

    2009-01-01

    Background When nicotine-dependent human subjects abstain from cigarette smoking, they exhibit deficits in working memory. An understanding of the neural substrates of such impairments may help to understand how nicotine affects cognition. Our aim, therefore, was to identify abnormalities in the circuitry that mediates working memory in nicotine-dependent subjects after they initiate abstinence from smoking. Methods We used blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI) to study eight smokers while they performed a letter version of the N-Back working memory task under satiety (≤1.5 hours abstinence) and abstinence (≥14 hours abstinence) conditions. Results Task-related activity in the left dorsal lateral prefrontal cortex (DLPFC) showed a significant interaction between test session (satiety, abstinence) and task load (1-back, 2-back, and 3-back). This interaction reflected the fact that task-related activity in the satiety condition was relatively low during performance of the 1-back task but greater at the more difficult task levels, whereas task-related activity in the abstinence condition was relatively high at the 1-back level and did not increase at the more difficult task levels. Conclusions We conclude that neural processing related to working memory in the left DLPFC is less efficient during acute abstinence from smoking than at smoking satiety. PMID:16038685

  20. 22 CFR 513.620 - Effect of violation.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 2 2011-04-01 2009-04-01 true Effect of violation. 513.620 Section 513.620 Foreign Relations BROADCASTING BOARD OF GOVERNORS GOVERNMENT DEBARMENT AND SUSPENSION (NONPROCUREMENT) AND... Effect of violation. (a) In the event of a violation of this subpart as provided in § 513.615, and...

  1. 22 CFR 513.620 - Effect of violation.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 2 2014-04-01 2014-04-01 false Effect of violation. 513.620 Section 513.620 Foreign Relations BROADCASTING BOARD OF GOVERNORS GOVERNMENT DEBARMENT AND SUSPENSION (NONPROCUREMENT) AND... Effect of violation. (a) In the event of a violation of this subpart as provided in § 513.615, and...

  2. 22 CFR 513.620 - Effect of violation.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 2 2013-04-01 2009-04-01 true Effect of violation. 513.620 Section 513.620 Foreign Relations BROADCASTING BOARD OF GOVERNORS GOVERNMENT DEBARMENT AND SUSPENSION (NONPROCUREMENT) AND... Effect of violation. (a) In the event of a violation of this subpart as provided in § 513.615, and...

  3. Large-Scale Brain Network Coupling Predicts Acute Nicotine Abstinence Effects on Craving and Cognitive Function

    PubMed Central

    Lerman, Caryn; Gu, Hong; Loughead, James; Ruparel, Kosha; Yang, Yihong; Stein, Elliot A.

    2014-01-01

    IMPORTANCE Interactions of large-scale brain networks may underlie cognitive dysfunctions in psychiatric and addictive disorders. OBJECTIVES To test the hypothesis that the strength of coupling among 3 large-scale brain networks–salience, executive control, and default mode–will reflect the state of nicotine withdrawal (vs smoking satiety) and will predict abstinence-induced craving and cognitive deficits and to develop a resource allocation index (RAI) that reflects the combined strength of interactions among the 3 large-scale networks. DESIGN, SETTING, AND PARTICIPANTS A within-subject functional magnetic resonance imaging study in an academic medical center compared resting-state functional connectivity coherence strength after 24 hours of abstinence and after smoking satiety. We examined the relationship of abstinence-induced changes in the RAI with alterations in subjective, behavioral, and neural functions. We included 37 healthy smoking volunteers, aged 19 to 61 years, for analyses. INTERVENTIONS Twenty-four hours of abstinence vs smoking satiety. MAIN OUTCOMES AND MEASURES Inter-network connectivity strength (primary) and the relationship with subjective, behavioral, and neural measures of nicotine withdrawal during abstinence vs smoking satiety states (secondary). RESULTS The RAI was significantly lower in the abstinent compared with the smoking satiety states (left RAI, P = .002; right RAI, P = .04), suggesting weaker inhibition between the default mode and salience networks. Weaker inter-network connectivity (reduced RAI) predicted abstinence-induced cravings to smoke (r = −0.59; P = .007) and less suppression of default mode activity during performance of a subsequent working memory task (ventromedial prefrontal cortex, r = −0.66, P = .003; posterior cingulate cortex, r = −0.65, P = .001). CONCLUSIONS AND RELEVANCE Alterations in coupling of the salience and default mode networks and the inability to disengage from the default mode network may

  4. Cerenkov effect in Lorentz-violating vacua

    SciTech Connect

    Lehnert, Ralf; Potting, Robertus

    2004-12-15

    The emission of electromagnetic radiation by charges moving uniformly in a Lorentz-violating vacuum is studied. The analysis is performed within the classical Maxwell-Chern-Simons limit of the Standard-Model Extension and confirms the possibility of a Cerenkov-type effect. In this context, various properties of Cerenkov radiation including the rate, polarization, and propagation features, are discussed, and the backreaction on the charge is investigated. An interpretation of this effect supplementing the conventional one is given. The emerging physical picture leads to a universal methodology for studying the Cerenkov effect in more general situations.

  5. The Controversy between Abstinence-Only and Abstinence- Plus Approaches to Sexuality Education.

    ERIC Educational Resources Information Center

    Fisher, Jamie L.

    2002-01-01

    Asserts that the debate over abstinence-only versus abstinence-plus sexuality education has shifted from what best serves students to what best suits adults' beliefs. Though research suggests comprehensive approaches to sexuality education are the most effective in reducing risk, government funding supports abstinence-only programs, which have…

  6. Surviving Drug Addiction: The Effect of Treatment and Abstinence on Mortality

    PubMed Central

    Dennis, Michael L.; Laudet, Alexandre; Funk, Rodney R.; Simeone, Ronald S.

    2011-01-01

    Objectives. We examined the relationships between substance abuse treatment, abstinence, and mortality in a sample of individuals entering treatment. We also estimated overall mortality rates and the extent to which they varied according to demographic, clinical severity, and treatment variables. Methods. We used data from a 9-year longitudinal study of 1326 adults entering substance abuse treatment on the west side of Chicago, of whom 131 died (11.0 per 1000 person-years). Baseline predictors, initial and long-term treatment response, and substance use patterns were used to predict mortality rates and time to mortality. Results. Older age, health problems, and substance use were associated with an increased risk of mortality, and higher percentages of time abstinent and longer durations of continuous abstinence were associated with a reduced risk of mortality. Treatment readmission in the first 6 months after baseline was related to an increased likelihood of abstinence, whereas readmission after 6 months was related to a decreased likelihood of abstinence, suggesting that treatment timing is significant. Conclusions. Our findings suggest the need to shift the addiction treatment field from an acute care model to a chronic disease management paradigm and the need for more aggressive screening, intervention, and addiction management over time. PMID:21330586

  7. Effectiveness of abstinence-based incentives: interaction with intake stimulant test results.

    PubMed

    Stitzer, Maxine L; Petry, Nancy; Peirce, Jessica; Kirby, Kimberly; Killeen, Therese; Roll, John; Hamilton, John; Stabile, Patricia Q; Sterling, Robert; Brown, Chanda; Kolodner, Ken; Li, Rui

    2007-10-01

    Intake urinalysis test result (drug positive vs. negative) has been previously identified as a strong predictor of drug abuse treatment outcome, but there is little information about how this prognostic factor may interact with the type of treatment delivered. The authors used data from a multisite study of abstinence incentives for stimulant abusers enrolled in outpatient counseling treatment (N. M. Petry, J. M. Peirce, et al., 2005) to examine this question. The first study urine was used to stratify participants into stimulant negative (n = 306) versus positive (n = 108) subgroups. Abstinence incentives significantly improved retention in those testing negative but not in those testing positive. Findings suggest that stimulant abusers presenting to treatment with a stimulant-negative urine benefit from abstinence incentives, but alternative treatment approaches are needed for those who test stimulant positive at intake. PMID:17907862

  8. The Effects of E-Cigarette Visual Appearance on Craving and Withdrawal Symptoms in Abstinent Smokers

    PubMed Central

    Dawkins, Lynne; Munafò, Marcus; Christoforou, Gina; Olumegbon, Naomi; Soar, Kirstie

    2016-01-01

    Introduction Electronic cigarette (e-cigarette) use is becoming increasing popular among smokers and there is a plethora of devices available. Nicotine delivery is clearly important for reducing tobacco craving and withdrawal symptoms, but other sensor-motor aspects of e-cigarettes (such as visual appearance) may contribute to this effect. This study explored whether it is important for an e-cigarette to visually resemble a tobacco cigarette in order to reduce craving and withdrawal symptoms. Methods Sixty-three abstinent smokers (40% female, aged 18-65 years) who were not current e-cigarette users were randomly allocated to take ten 3-second puffs from either a white or a red first generation e-cigarette. Current craving (urge to smoke) and nicotine withdrawal symptoms (using the Mood and Physical Symptoms Scale; MPSS) were measured before and ten minutes after use. Results Linear regression revealed higher craving and withdrawal symptoms in the red versus the white condition but only among those who were e-cigarette naive (craving: B = .76, p = .009; withdrawal symptoms: B = 2.18, p = 0.009), not among those with e-cigarette experience (craving: B = −.08, p = 0.89; withdrawal symptoms: B = .24, p = .81), and these effects differed between groups (p = 0.04 and 0.01 for craving and withdrawal symptoms respectively). Conclusion Cigarette-like appearance was associated with a greater reduction in craving and withdrawal symptoms but only for those with no prior e-cigarette experience. This effect, putatively mediated via classical conditioning or expectancies, may aid understanding of smokers’ initial preferences for ‘cigalike’ e-cigarette devices. PMID:26415054

  9. Effectiveness of Abstinence-Based Incentives: Interaction with Intake Stimulant Test Results

    ERIC Educational Resources Information Center

    Stitzer, Maxine L.; Petry, Nancy; Peirce, Jessica; Kirby, Kimberly; Killeen, Therese; Roll, John; Hamilton, John; Stabile, Patricia Q.; Sterling, Robert; Brown, Chanda; Kolodner, Ken; Li, Rui

    2007-01-01

    Intake urinalysis test result (drug positive vs. negative) has been previously identified as a strong predictor of drug abuse treatment outcome, but there is little information about how this prognostic factor may interact with the type of treatment delivered. The authors used data from a multisite study of abstinence incentives for stimulant…

  10. Attacking the Personal Fable: Role-Play and Its Effect on Teen Attitudes toward Sexual Abstinence.

    ERIC Educational Resources Information Center

    Saltz, Eli; And Others

    1994-01-01

    Examines role playing as a tool for changing teenagers' attitudes about sex behavior and the consequences of teen pregnancy. A sample of 267 ninth-grade students attending a high-risk urban school participated. Role playing and watching videos of friends' role playing significantly increased favorable attitudes toward abstinence in girls but not…

  11. Evidence on the Effectiveness of Abstinence Education: An Update. No. 2372

    ERIC Educational Resources Information Center

    Kim, Christine C.; Rector, Robert

    2010-01-01

    Teen sexual activity is costly, not just for teens, but also for society. Teens who engage in sexual activity risk a host of negative outcomes including STD infection, emotional and psychological harm, and out-of-wedlock childbearing. Genuine abstinence education is therefore crucial to the physical and psycho-emotional well-being of the nation's…

  12. Weighing the Evidence: A Systematic Review on Long-Term Neurocognitive Effects of Cannabis Use in Abstinent Adolescents and Adults.

    PubMed

    Ganzer, Florian; Bröning, Sonja; Kraft, Stefanie; Sack, Peter-Michael; Thomasius, Rainer

    2016-06-01

    Findings on neurocognitive effects of sustained cannabis use are heterogeneous. Previous work has rarely taken time of abstinence into account. In this review, we focus on understanding sustained effects of cannabis, which begin when clinical symptoms of the drug have worn off after at least 14 days. We conducted a search between 2004 and 2015 and found 38 studies with such a prolonged abstinence phase. Study-design quality in terms of evidence-based medicine is similar among studies. Studies found some attention or concentration deficits in cannabis users (CU). There is evidence that chronic CU might experience sustained deficits in memory function. Findings are mixed regarding impairments in inhibition, impulsivity and decision making for CU, but there is a trend towards worse performance. Three out of four studies found evidence that motor function remains impaired even after a time of abstinence, while no impairments in visual spatial functioning can be concluded. Functional imaging demonstrates clear differences in activation patterns between CU and controls especially in hippocampal, prefrontal and cerebellar areas. Structural differences are found in cortical areas, especially the orbitofrontal region and the hippocampus. Twenty studies (57 %) reported data on outcome effects, leading to an overall effect size of r mean = .378 (CI 95 % = [.342; .453]). Heavy use is found to be more consistently associated with effects in diverse domains than early age of onset. Questions of causality-in view of scarce longitudinal studies, especially those targeting co-occurring psychiatric disorders-are discussed. PMID:27125202

  13. The Effects of Lithium Carbonate Supplemented with Nitrazepam on Sleep Disturbance during Cannabis Abstinence

    PubMed Central

    Allsop, David J.; Bartlett, Delwyn J.; Johnston, Jennifer; Helliwell, David; Winstock, Adam; McGregor, Iain S.; Lintzeris, Nicholas

    2015-01-01

    actigraphy measures of sleep disturbance, warranting further investigation. Discord between objective and subjective sleep indices suggest caution in evaluating treatment interventions with self-report sleep data only. Citation: Allsop DJ, Bartlett DJ, Johnston J, Helliwell D, Winstock A, McGregor IS, Lintzeris N. The effects of lithium carbonate supplemented with nitrazepam on sleep disturbance during cannabis abstinence. J Clin Sleep Med 2015;11(10):1153–1162. PMID:26285109

  14. 29 CFR 452.5 - Effect of violation on outcome.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 2 2010-07-01 2010-07-01 false Effect of violation on outcome. 452.5 Section 452.5 Labor... DISCLOSURE ACT OF 1959 General Considerations § 452.5 Effect of violation on outcome. Since the remedy under... affected the outcome of an election” 5 the Secretary as a matter of policy will not file suit to...

  15. Pushing the rules: effects and aftereffects of deliberate rule violations.

    PubMed

    Wirth, Robert; Pfister, Roland; Foerster, Anna; Huestegge, Lynn; Kunde, Wilfried

    2016-09-01

    Most of our daily life is organized around rules and social norms. But what makes rules so special? And what if one were to break a rule intentionally? Can we simply free us from the present set of rules or do we automatically adhere to them? How do rule violations influence subsequent behavior? To investigate the effects and aftereffects of violating simple S-R rule, we conducted three experiments that investigated continuous finger-tracking responses on an iPad. Our experiments show that rule violations are distinct from rule-based actions in both response times and movement trajectories, they take longer to initiate and execute, and their movement trajectory is heavily contorted. Data not only show differences between the two types of response (rule-based vs. violation), but also yielded a characteristic pattern of aftereffects in case of rule violations: rule violations do not trigger adaptation effects that render further rule violations less difficult, but every rule violation poses repeated effort on the agent. The study represents a first step towards understanding the signature and underlying mechanisms of deliberate rule violations, they cannot be acted out by themselves, but require the activation of the original rule first. Consequently, they are best understood as reformulations of existing rules that are not accessible on their own, but need to be constantly derived from the original rule, with an add-on that might entail an active tendency to steer away from mental representations that reflect (socially) unwanted behavior. PMID:26245822

  16. Expectancies for the Effectiveness of Different Tobacco Interventions Account for Racial and Gender Differences in Motivation to Quit and Abstinence Self-Efficacy

    PubMed Central

    Leventhal, Adam M.; Stevens, Erin N.; Trent, Lindsay R.; Clark, C. Brendan; Lahti, Adrienne C.; Hendricks, Peter S.

    2014-01-01

    Introduction: Racial and gender disparities for smoking cessation might be accounted for by differences in expectancies for tobacco interventions, but few studies have investigated such differences or their relationships with motivation to quit and abstinence self-efficacy. Methods: In this cross-sectional study, 673 smokers (African American: n = 443, 65.8%; women: n = 222, 33.0%) under criminal justice supervision who enrolled in a clinical smoking cessation trial in which all received bupropion and half received counseling. All participants completed pretreatment measures of expectancies for different tobacco interventions, motivation to quit, and abstinence self-efficacy. The indirect effects of race and gender on motivation to quit and abstinence self-efficacy through expectancies for different tobacco interventions were evaluated. Results: African Americans’ stronger expectancies that behavioral interventions would be effective accounted for their greater motivation to quit and abstinence self-efficacy. Women’s stronger expectancies for the effectiveness of pharmacotherapy accounted for their greater motivation to quit, whereas their stronger expectancies for the effectiveness of behavioral treatments accounted for their greater abstinence self-efficacy. Conclusions: Findings point to the mediating role of expectancies for treatment effectiveness and suggest the importance of exploring expectancies among African Americans and women as a way to augment motivation and self-efficacy. PMID:24719492

  17. Cardiac autonomic function during sleep: effects of alcohol dependence and evidence of partial recovery with abstinence

    PubMed Central

    de Zambotti, Massimiliano; Willoughby, Adrian R.; Baker, Fiona C.; Sugarbaker, David S.; Colrain, Ian M.

    2015-01-01

    Chronic alcoholism is associated with the development of cardiac and peripheral autonomic nervous system (ANS) pathology. The aim of the present study was to evaluate the extent to which recovery in ANS function could be demonstrated over the first 4 months of abstinence. Fifteen alcoholics (7 women) were studied on three occasions: within a month of detoxification, at approximately 2 months post-detox, and at 4 months post-detox. Thirteen control subjects (6 women) were also studied on three occasions with inter-study intervals matching those of the alcoholics. Six alcoholics relapsed, 48.7 ± 27.9 days following the initial PSG session. ANS function was assessed in the first part of stable non-rapid eye movement sleep. Frequency-domain power spectral analysis of heart rate variability (HRV) produced variables including: heart rate (HR), total power (TP; an index representing total HR variability), High Frequency power (HFa; an index reflecting cardiac vagal modulation), HF proportion of total power (HFprop sympathovagal balance), and HF peak frequency (HFpf; an index reflecting respiration rate). Overall, high total and high frequency variability and low sympathovagal balance and myocardial contractility are considered as desired conditions to promote cardiovascular health. At initial assessment, alcoholics had a higher HR (p < 0.001) and respiratory rate (p < 0.01), and lower vagal activity (HFa; p < 0.01) than controls. Alcoholics showed evidence of recovery in HR (p = 0.039) and HFa (p = 0.031) with 4 months of abstinence. Alcoholics with higher TP at the initial visit showed a greater improvement in TP from the initial to the 4-month follow-up session (r = 0.75, p < 0.05). Alcoholics showed substantial recovery in HR and vagal modulation of HRV with 4 months of abstinence, with evidence that the extent of recovery in HRV may be partially determined by the extent of alcohol dependence-related insult to the cardiac ANS system. These data support other studies

  18. Cardiac autonomic function during sleep: effects of alcohol dependence and evidence of partial recovery with abstinence.

    PubMed

    de Zambotti, Massimiliano; Willoughby, Adrian R; Baker, Fiona C; Sugarbaker, David S; Colrain, Ian M

    2015-06-01

    Chronic alcoholism is associated with the development of cardiac and peripheral autonomic nervous system (ANS) pathology. The aim of the present study was to evaluate the extent to which recovery in ANS function could be demonstrated over the first 4 months of abstinence. Fifteen alcoholics (7 women) were studied on three occasions: within a month of detoxification, at approximately 2 months post-detox, and at 4 months post-detox. Thirteen control subjects (6 women) were also studied on three occasions with inter-study intervals matching those of the alcoholics. Six alcoholics relapsed, 48.7 ± 27.9 days following the initial PSG session. ANS function was assessed in the first part of stable non-rapid eye movement sleep. Frequency-domain power spectral analysis of heart rate variability (HRV) produced variables including: heart rate (HR), total power (TP; an index representing total HR variability), High Frequency power (HFa; an index reflecting cardiac vagal modulation), HF proportion of total power (HFprop sympathovagal balance), and HF peak frequency (HFpf; an index reflecting respiration rate). Overall, high total and high frequency variability and low sympathovagal balance and myocardial contractility are considered as desired conditions to promote cardiovascular health. At initial assessment, alcoholics had a higher HR (p < 0.001) and respiratory rate (p < 0.01), and lower vagal activity (HFa; p < 0.01) than controls. Alcoholics showed evidence of recovery in HR (p = 0.039) and HFa (p = 0.031) with 4 months of abstinence. Alcoholics with higher TP at the initial visit showed a greater improvement in TP from the initial to the 4 month follow-up session (r = 0.75, p < 0.05). Alcoholics showed substantial recovery in HR and vagal modulation of HRV with 4 months of abstinence, with evidence that the extent of recovery in HRV may be partially determined by the extent of alcohol dependence-related insult to the cardiac ANS system. These data support other studies

  19. Environmental enrichment counters cocaine abstinence-induced stress and brain reactivity to cocaine cues but fails to prevent the incubation effect.

    PubMed

    Thiel, Kenneth J; Painter, Michael R; Pentkowski, Nathan S; Mitroi, Danut; Crawford, Cynthia A; Neisewander, Janet L

    2012-03-01

    Environmental enrichment (EE) during a period of forced abstinence attenuates incentive motivational effects of cocaine-paired stimuli. Here we examined whether EE during forced abstinence from cocaine self-administration would prevent time-dependent increases in cue-elicited cocaine-seeking behavior (i.e. the incubation effect). Rats were trained to self-administer cocaine, which was paired with light/tone cues, for 15 days while living in isolated conditions (IC). Controls received yoked saline infusions. Subsequently, rats were assigned to live in either continued IC or EE for either 1 or 21 days of forced abstinence prior to a test for cocaine-seeking behavior. During testing, responding resulted only in presentation of the light/tone cues. Contrary to our prediction, cocaine-seeking behavior increased over time regardless of living condition during abstinence; however, EE attenuated cocaine-seeking behavior relative to IC regardless of length of abstinence. Brains were harvested and trunk blood was collected immediately after the 60-minute test and later assayed. Results indicated that short-term EE elevated hippocampal brain-derived neurotrophic factor and reduced plasma corticosterone compared with IC. Furthermore, 21 days of EE during forced abstinence prevented increases in the cue-elicited amygdala phosphorylated extracellular signal-regulated kinase expression that was observed in IC rats. These findings suggest that EE attenuates incentive motivational effects of cocaine cues through a mechanism other than preventing the incubation effect, perhaps involving reduction of stress and neural activity in response to cocaine-paired cues during acute withdrawal. PMID:21812872

  20. Environmental enrichment counters cocaine abstinence-induced stress and brain reactivity to cocaine cues but fails to prevent the incubation effect

    PubMed Central

    Thiel, Kenneth J.; Painter, Michael R.; Pentkowski, Nathan S.; Mitroi, Danut; Crawford, Cynthia A.; Neisewander, Janet L.

    2011-01-01

    Environmental enrichment (EE) during a period of forced abstinence attenuates incentive motivational effects of cocaine-paired stimuli. Here we examined whether EE during forced abstinence from cocaine self-administration would prevent time-dependent increases in cue-elicited cocaine-seeking behavior (i.e., the incubation effect). Rats were trained to self-administer cocaine, which was paired with light/tone cues, for 15 days while living in isolated conditions (IC). Controls received yoked saline infusions. Subsequently, rats were assigned to live in either continued IC or EE for either 1 or 21 days of forced abstinence prior to a test for cocaine-seeking behavior. During testing, responding resulted only in presentation of the light/tone cues. Contrary to our prediction, cocaine-seeking behavior increased over time regardless of living condition during abstinence; however, EE attenuated cocaine-seeking behavior relative to IC regardless of length of abstinence. Brains were harvested and trunk blood was collected immediately after the 60-min test and later assayed. Results indicated that short-term EE elevated hippocampal brain-derived neurotrophic factor and reduced plasma corticosterone compared to IC. Furthermore, 21 days of EE during forced abstinence prevented increases in the cue-elicited amygdala phosphorylated extracellular signal-regulated kinase expression that was observed in IC rats. These findings suggest that EE attenuates incentive motivational effects of cocaine cues through a mechanism other than preventing the incubation effect, perhaps involving reduction of stress and neural activity in response to cocaine-paired cues during acute withdrawal. PMID:21812872

  1. Voluntary co-consumption of alcohol and nicotine: Effects of abstinence, intermittency, and withdrawal in mice.

    PubMed

    O'Rourke, Kyu Y; Touchette, Jillienne C; Hartell, Elizabeth C; Bade, Elizabeth J; Lee, Anna M

    2016-10-01

    Alcohol and nicotine are often used together, and there is a high rate of co-occurrence between alcohol and nicotine addiction. Most animal models studying alcohol and nicotine interactions have utilized passive drug administration, which may not be relevant to human co-addiction. In addition, the interactions between alcohol and nicotine in female animals have been understudied, as most studies have used male animals. To address these issues, we developed models of alcohol and nicotine co-consumption in male and female mice that utilized voluntary, oral consumption of unsweetened alcohol, nicotine and water. We first examined drug consumption and preference in single-drug, sequential alcohol and nicotine consumption tests in male and female C57BL/6 and DBA/2J mice. We then tested chronic continuous and intermittent access alcohol and nicotine co-consumption procedures. We found that male and female C57BL/6 mice readily co-consumed unsweetened alcohol and nicotine. In our continuous co-consumption procedures, we found that varying the available nicotine concentration during an alcohol abstinence period affected compensatory nicotine consumption during alcohol abstinence, and affected rebound alcohol consumption when alcohol was re-introduced. Consumption of alcohol and nicotine in an intermittent co-consumption procedure produced higher alcohol consumption levels, but not nicotine consumption levels, compared with the continuous co-consumption procedures. Finally, we found that intermittent alcohol and nicotine co-consumption resulted in physical dependence. Our data show that these voluntary co-consumption procedures can be easily performed in mice and can be used to study behavioral interactions between alcohol and nicotine consumption, which may better model human alcohol and nicotine co-addiction. PMID:27342124

  2. Making Sense of Abstinence

    ERIC Educational Resources Information Center

    Taverner, Bill; Montfort, Sue

    2011-01-01

    Young people need to know that abstinence is a far more complex, difficult concept than it is often portrayed. Abstinence is a decision about sexual behaviors that a person may make throughout his or her life. It is a choice made at a specific time in a specific situation, for a specific period of time, whether one is in a partnered relationship…

  3. rsfMRI effects of KB220Z™ on neural pathways in reward circuitry of abstinent genotyped heroin addicts.

    PubMed

    Blum, Kenneth; Liu, Yijun; Wang, Wei; Wang, Yarong; Zhang, Yi; Oscar-Berman, Marlene; Smolen, Andrew; Febo, Marcelo; Han, David; Simpatico, Thomas; Cronjé, Frans J; Demetrovics, Zsolt; Gold, Mark S

    2015-03-01

    Recently, Willuhn et al. reported that cocaine use and even non-substance-related addictive behavior increases as dopaminergic function is reduced. Chronic cocaine exposure has been associated with decreases in D2/D3 receptors and was also associated with lower activation of cues in occipital cortex and cerebellum, in a recent PET study by Volkow's et al. Therefore, treatment strategies, like dopamine agonist therapy, that might conserve dopamine function may be an interesting approach to relapse prevention in psychoactive drug and behavioral addictions. To this aim, we evaluated the effect of KB220Z™ on reward circuitry of 10 heroin addicts undergoing protracted abstinence (average 16.9 months). In a randomized placebo-controlled crossover study of KB220Z, five subjects completed a triple-blinded experiment in which the subject, the person administering the treatment, and the person evaluating the response to treatment were blinded to the treatment that any particular subject was receiving. In addition, nine subjects were genotyped utilizing the GARSDX™ test. We preliminarily report that KB220Z induced an increase in BOLD activation in caudate-accumbens-dopaminergic pathways compared to placebo following 1-hour acute administration. Furthermore, KB220Z also reduced resting-state activity in the putamen of abstinent heroin addicts. In the second phase of this pilot study of all 10 abstinent heroin-dependent subjects, we observed that three brain regions of interest were significantly activated from resting state by KB220Z compared to placebo (p < 0.05). Increased functional connectivity was observed in a putative network that included the dorsal anterior cingulate, medial frontal gyrus, nucleus accumbens, posterior cingulate, occipital cortical areas, and cerebellum. These results and other quantitative electroencephalogy (qEEG) study results suggest a putative anti-craving/anti-relapse role of KB220Z in addiction by direct or indirect dopaminergic interaction

  4. rsfMRI effects of KB220Z™ on Neural Pathways in Reward Circuitry of Abstinent Genotyped Heroin Addicts

    PubMed Central

    Blum, Kenneth; Liu, Yijun; Wang, Wei; Wang, Yarong; Zhang, Yi; Oscar-Berman, Marlene; Smolen, Andrew; Febo, Marcelo; Han, David; Simpatico, Thomas; Cronjé, Frans J; Demetrovics, Zsolt; Gold, Mark S.

    2016-01-01

    Recently Willuhn et al. reported that cocaine use and even non-substance related addictive behavior, increases, as dopaminergic function is reduced. Chronic cocaine exposure has been associated with decreases in D2/D3 receptors, also associated with lower activation to cues in occipital cortex and cerebellum in a recent PET study from Volkow’s group. Therefore, treatment strategies, like dopamine agonist therapy, that might conserve dopamine function may be an interesting approach to relapse prevention in psychoactive drug and behavioral addictions. To this aim, we evaluated the effect of KB220Z™ on reward circuitry of ten heroin addicts undergoing protracted abstinence, an average 16.9 months. In a randomized placebo-controlled crossover study of KB220Z™ five subjects completed a triple blinded–experiment in which the subject, the person administering the treatment and the person evaluating the response to treatment were blinded as to which treatment any particular subject was receiving. In addition, nine subjects total were genotyped utilizing the GARSRX™ test. We preliminarily report that KB220Z ™ induced an increase in BOLD activation in caudate-accumbens-dopaminergic pathways compared to placebo following one-hour acute administration. Furthermore, KB220Z™ also reduced resting state activity in the putamen of abstinent heroin addicts. In the second phase of this pilot study of all ten abstinent heroin-dependent subjects, three brain regions of interest (ROIs) we observed to be significantly activated from resting state by KB220Z compared to placebo (P < 0.05). Increased functional connectivity was observed in a putative network that included the dorsal anterior cingulate, medial frontal gyrus, nucleus accumbens, posterior cingulate, occipital cortical areas and cerebellum. These results and other qEEG study results suggest a putative anti-craving/anti-relapse role for KB220Z in addiction by direct or indirect dopaminergic interaction. Due to

  5. Observation of an unusually large atomic parity-violation effect

    NASA Astrophysics Data System (ADS)

    Tsigutkin, Konstantin

    2010-03-01

    We report on observation of a large parity-violation effect in the atoms of ytterbium (Yb). This left-right asymmetry appears naturally in the Standard Model, and is associated with the exchange of a virtual heavy ``gauge" boson between subatomic particles. Eventually, parity violation has been observed and precisely measured by a number of groups in several different atoms, culminating in a 0.3% measurement in cesium (Cs) by Carl Wieman and co-workers at Boulder. The parity-violating amplitude of the 6x^2 ^1S0 -> 5d6s ^3D1 408-nm forbidden transition of ytterbium is found to be two orders of magnitude larger than in cesium. This is the largest atomic parity-violating amplitude yet observed. This also opens the way to future measurements of the parity violation effects for different Yb isotopes in order to test the effect of the neutron distributions within the nucleus and detect the so-called ``anapole moment" by comparing parity-violating amplitudes for various hyperfine components of the transition. So far, Cs is the only system where such a moment has been detected. Measurements of anapole moments are important for understanding the electroweak interactions within the nucleus which are hard to probe by other means.

  6. Gene × Abstinence Effects on Drug Cue Reactivity in Addiction: Multimodal Evidence

    PubMed Central

    Moeller, Scott J.; Parvaz, Muhammad A.; Shumay, Elena; Beebe-Wang, Nicasia; Konova, Anna B.; Alia-Klein, Nelly; Volkow, Nora D.

    2013-01-01

    Functional polymorphisms in the dopamine transporter gene (DAT1 or SLC6A3) modulate responsiveness to salient stimuli, such that carriers of one 9R-allele of DAT1 (compared with homozygote carriers of the 10R-allele) show heightened reactivity to drug-related reinforcement in addiction. Here, using multimodal neuroimaging and behavioral dependent variables in 73 human cocaine-addicted individuals and 47 healthy controls, we hypothesized and found that cocaine-addicted carriers of a 9R-allele exhibited higher responses to drug cues, but only among individuals who had used cocaine within 72 h of the study as verified by positive cocaine urine screens (a state characterized by intense craving). Importantly, this responsiveness to drug cues was reliably preserved across multimodal imaging and behavioral probes: psychophysiological event-related potentials, self-report, simulated cocaine choice, and fMRI. Because drug cues contribute to relapse, our results identify the DAT1R 9R-allele as a vulnerability allele for relapse especially during early abstinence (e.g., detoxification). PMID:23761898

  7. Effects of acute smoking on brain activity vary with abstinence in smokers performing the N-Back Task: a preliminary study

    PubMed Central

    Xu, Jiansong; Mendrek, Adrianna; Cohen, Mark S.; Monterosso, John; Simon, Sara; Brody, Arthur L.; Jarvik, Murray; Rodriguez, Paul; Ernst, Monique; London, Edythe D.

    2007-01-01

    We previously reported that compared with a non-deprivation state, overnight abstinence from cigarette smoking was associated with higher brain activity in the left dorsolateral prefrontal cortex (L-DLPFC) during a low demanding working memory challenge, and little increase beyond this activity level during more taxing working memory conditions. In the present study, we aimed to assess how recent smoking (overnight abstinence Vs smoking ad libitum) influenced the effect of smoking a cigarette on brain activity related to a working memory challenge. Six smokers performed the N-Back working memory task during functional magnetic resonance imaging (fMRI) both before and after smoking a cigarette in each of two test sessions: one following overnight abstinence from smoking (>13 h) and the other following ad libitum smoking. Task-related activity in L-DLPFC showed a significant interaction between the effects of acute smoking, test session, and task load. After overnight abstinence, post-smoking brain activity in L-DLPFC was lower than before smoking at low task-load and higher at high task-load; corresponding activity on a day of ad libitum smoking was higher at low load and lower at high task-load after smoking during the session. These data suggest that the effect of acute smoking on working-memory processing depends on recent prior smoking and task-load. In particular, they provide preliminary evidence that functional efficiency of working memory is improved by smoking a cigarette during abstinence, while the effect of a cigarette in a non-deprived state varies with the nature and difficulty of the working memory challenge. This interaction merits further examination in larger studies specifically designed to consider this issue. PMID:17088048

  8. Effect of oral acamprosate on abstinence in patients with alcohol dependence in a double-blind, placebo-controlled trial: the role of patient motivation.

    PubMed

    Mason, Barbara J; Goodman, Anita M; Chabac, Sylvie; Lehert, Philippe

    2006-08-01

    This is the first US study to evaluate the clinical efficacy of acamprosate (Campral), a newly FDA-approved medication for maintaining abstinence in patients with alcohol dependence following alcohol withdrawal. We compared effects of the standard 2 g dose (n=258) and an exploratory 3 g dose of acamprosate (n=83) versus placebo (n=260), and evaluated drug safety in a double-blind, placebo-controlled 6-month trial conducted in 21 outpatient clinics across the US. Participants were 601 volunteers with current alcohol dependence recruited primarily by advertisement. All patients concomitantly received eight sessions of brief manual-guided counseling (www.alcoholfree.info). The main outcome measure was the percentage of alcohol-free days over the 6-month study. Self-report was validated by breath alcohol concentration, gamma-glutamyltransferase (GGT) and collateral informant interviews. The percentage of abstinent days did not differ significantly across groups in a priori analysis (54.3% for placebo, 56.1% for 2 g, 60.7% for 3 g). Post-hoc analysis controlling for baseline variables and treatment exposure found acamprosate was associated with a significantly higher percentage of abstinent days than placebo (52.3% for placebo, 58.2% for 2 g, 62.7% for 3 g; P=0.01), with an even greater effect in the subgroup of 241 patients having a baseline goal of abstinence (58.1% for placebo, 70.0% for 2 g, 72.5% for 3 g; P=0.02). There were no deaths or serious drug-related adverse events. The US study findings suggest that acamprosate is safe and well tolerated in a broadly inclusive sample of alcoholics and appears effective in populations of patients motivated to have a treatment goal of abstinence. PMID:16546214

  9. Stereological study of the effects of morphine consumption and abstinence on the number of the neurons and oligodendrocytes in medial prefrontal cortex of rats

    PubMed Central

    Rafati, Ali; Torabi, Nihad

    2013-01-01

    Quantitative studies to date on the effects of opioid consumption and abstinence on the nervous system using modern stereological methods have not received enough attention. In addition, they have yielded controversial results. The present study was conducted to investigate the effects of morphine, with or without abstinence, on the neurons and oligodendrocytes of the medial prefrontal cortex (MPFC) in rats using quantitative stereological methods. The male rats were divided into four groups: the first (saline [SAL]) and second (morphine [MOR]) groups were treated with saline and an escalating dose of morphine (5-20 mg/kg) for 30 days, respectively; the third (SAL+abstinence [ABS]) and fourth (MOR+ABS) groups were treated in the same manner as the previous groups plus they had a 30-day abstinence period. The results showed that the volume of the MPFC and its subdivisions decreased by approximately 15% in the MOR group compared with that in the SAL group (P<0.05). In addition, the volume decreased by approximately 24% in the MOR+ABS group compared with that in the SAL+ABS group (P<0.05). The number of neurons in the MOR and MOR+ABS groups decreased by approximately 44% and 35%, respectively, compared with that in their corresponding control groups. Moreover, the number of the oligodendrocytes in the MOR and MOR+ABS groups decreased by approximately 41% and 37%, respectively. No significant difference was noted in the number of cells in the MOR and MOR+ABS groups. In conclusion, morphine consumption leads to a permanent reduction in the number of neurons and oligodendrocytes, and no additional neuron and oligodendrocyte loss occurs after abstinence. PMID:24179694

  10. Neonatal abstinence syndrome

    MedlinePlus

    NAS; Neonatal abstinence symptoms ... may contribute to the severity of a baby's NAS symptoms. ... symptoms of withdrawal. Even after medical treatment for NAS is over and babies leave the hospital, they ...

  11. Matter effect to T violation at a neutrino factory

    SciTech Connect

    Miura, Takahiro; Takasugi, Eiichi; Kuno, Yoshitaka; Yoshimura, Masaki

    2001-07-01

    We analyze T violation in neutrino oscillations by using perturbation methods with respect to {Delta}m{sub 21}{sup 2}L/2E and {delta}a(x)L/2E, where {delta}a(x) represents the matter density fluctuation from its average value. We find that the matter contribution to T violation arises from interference between {Delta}m{sub 21}{sup 2}L/2E and {delta}a(x)L/2E. To second order, the symmetric and asymmetric matter density fluctuations give effects to the sin{delta} (intrinsic) and the cos{delta} (fake) parts of T violation. We give their analytic forms and analyze the matter contribution to the sin{delta} and cos{delta} terms. We find that, for L=3000 km, both the symmetric and asymmetric matter density fluctuations give negligible contributions to T violation and that thus the constant (average) matter density gives a good approximation. On the other hand, we argue that, for L=7000 km or longer, T violation turns out to become very small due to the cancellation between the first and second order terms. This shows that the constant (average) matter approximation is not valid.

  12. [Periodic abstinence: its possibilities].

    PubMed

    1981-05-01

    Experience with family planning mehods requiring periodic sexual abstinence has been varied. During the last decade interest has centered on 2 methods, the cervical mucus and the sympto-thermal, which are based on identifying the onset of the fertile period. During the 1970s, the Australian physicians John and Evelyn Billings developed the cervical mucus method, in which changes in the quanitity and characteristics of cervical mucus are used to determine the moment of ovulation. The sympto-thermal method depends on identification of the slight rise in basal body temperature that occurs in the latter part of the menstrual cycle as well as cervical mucus changes and sometimes the calendar to determine the fertile period. The Catholic Church has been the main proponent of periodic abstinence methods, but since 1973 the World Health Organization has invested US$3.3 million on research in such methods. The Billings method requires differentiating between dry, wet, and very wet mucus in the vagina and between different consistencies of mucus. The method ususally requires 1-3 months for instruction and sexual abstinence is usually recommended for the 1st month. The average number of days of required abstinence was 9 in a study of 66 women and 15-18 in a study of 870 women. Many women with short menstrual cycles do not experience postmenstrual dry days, in which case abstinence may be required as many as 13 days out of 23. 18.8% of users of periodic abstinence methods in 1 North American study became pregnant in the 1st year, but most were using the calendar method. Women who desired to terminate childbearing had only about 1/2 as many failures with periodic abstinence methods as did women wishing to postpone a birth. PMID:12311397

  13. Effect of bulk Lorentz violation on anisotropic brane cosmologies

    SciTech Connect

    Heydari-Fard, Malihe

    2012-04-01

    The effect of Lorentz invariance violation in cosmology has attracted a considerable amount of attention. By using a dynamical vector field assumed to point in the bulk direction, with Lorentz invariance holding on the brane, we extend the notation of Lorentz violation in four dimensions Jacobson to a five-dimensional brane-world. We obtain the general solution of the field equations in an exact parametric form for Bianchi type I space-time, with perfect fluid as a matter source. We show that the brane universe evolves from an isotropic/anisotropic state to an isotropic de Sitter inflationary phase at late time. The early time behavior of anisotropic brane universe is largely dependent on the Lorentz violating parameters β{sub i},i = 1,2,3 and the equation of state of the matter, while its late time behavior is independent of these parameters.

  14. Abstinence from cocaine-self-administration activates the nELAV/GAP -43 pathway in the hippocampus: A stress-related effect?

    PubMed

    Pascale, Alessia; Osera, Cecilia; Moro, Federico; Di Clemente, Angelo; Giannotti, Giuseppe; Caffino, Lucia; Govoni, Stefano; Fumagalli, Fabio; Cervo, Luigi

    2016-06-01

    We previously demonstrated that nELAV/GAP-43 pathway is pivotal for learning and its hippocampal expression is up-regulated by acute stress following repeated cocaine administration. We therefore hypothesized that abstinence-induced stress may sustain nELAV/GAP-43 pathway during early abstinence following 2 weeks of cocaine self-administration. We found that contingent, but not non-contingent, cocaine exposure selectively increases hippocampal nELAV, but not GAP-43, expression immediately after the last self-administration session, an effect that wanes after 24 h and that comes back 7 days later when nELAV activation becomes associated with increased expression of GAP-43, an effect again observed only in animals self-administering the psychostimulant. Such effect is specific for nELAV since the ubiquitous ELAV/HuR is unchanged. This nELAV profile suggests that its initial transient alteration is perhaps related to the daily administration of cocaine, while the increase in the nELAV/GAP-43 pathway following a week of abstinence may reflect the activation of this cascade as a target of stressful conditions associated with drug-related memories. © 2016 Wiley Periodicals, Inc. PMID:26850084

  15. Abstinence-Conflict Model: Toward an Optimal Animal Model for Screening Medications Promoting Drug Abstinence.

    PubMed

    Peck, J A

    2016-01-01

    Drug addiction is a significant health and societal problem for which there is no highly effective long-term behavioral or pharmacological treatment. A rising concern are the use of illegal opiate drugs such as heroin and the misuse of legally available pain relievers that have led to serious deleterious health effects or even death. Therefore, treatment strategies that prolong opiate abstinence should be the primary focus of opiate treatment. Further, because the factors that support abstinence in humans and laboratory animals are similar, several animal models of abstinence and relapse have been developed. Here, we review a few animal models of abstinence and relapse and evaluate their validity and utility in addressing human behavior that leads to long-term drug abstinence. Then, a novel abstinence "conflict" model that more closely mimics human drug-seeking episodes by incorporating negative consequences for drug seeking (as are typical in humans, eg, incarceration and job loss) and while the drug remains readily available is discussed. Additionally, recent research investigating both cocaine and heroin seeking in rats using the animal conflict model is presented and the implications for heroin treatments are examined. Finally, it is argued that the use of animal abstinence/relapse models that more closely approximate human drug addiction, such as the abstinence-conflict model, could lead to a better understanding of the neurobiological and environmental factors that support long-term drug abstinence. In turn, this will lead to the development of more effective environmental and pharmacotherapeutic interventions to treat opiate addiction and addiction to other drugs of abuse. PMID:27055619

  16. Predictors of Smokeless Tobacco Abstinence

    ERIC Educational Resources Information Center

    Ebbert, Jon O.; Glover, Elbert D.; Shinozaki, Eri; Schroeder, Darrell R.; Dale, Lowell C.

    2008-01-01

    Objectives: To investigate predictors of tobacco abstinence among smokeless tobacco (ST) users. Methods: Logistic regression analyses assessed characteristics associated with tobacco abstinence among ST users receiving bupropion SR. Results: Older age was associated with increased tobacco abstinence in both placebo and bupropion SR groups at end…

  17. Specificity of verbal learning impairment and recovery in a marijuana-dependent male: the effects of sustained marijuana abstinence

    PubMed Central

    Vadhan, Nehal P.; van Gorp, Wilfred G.; Levin, Frances R.

    2011-01-01

    We present the case of a young adult in treatment for marijuana dependence, with recurrent depression and a history of possible TBI, complaining of concentration, memory and initiation problems. Testing at treatment baseline revealed performance that was generally in the High Average range on measures of reaction time and attention, with a selective impairment in verbal learning (Borderline to Extremely Low range). Following 8 weeks of abstinence from marijuana, his verbal learning recovered to expected levels (High Average range), with signs of improved learning strategy, efficiency, rate, and capacity. However, his reaction time and attention showed minimal evidence of change. This finding is consistent with the literature that demonstrates that marijuana-associated neurocognitive impairments may be specific to verbal learning and may remit with abstinence. The clinical implications of these case findings and recommendations for neuropsychological assessment of marijuana abusers are discussed. PMID:21253958

  18. Effect of naltrexone on alcohol consumption during chronic alcohol drinking and after a period of imposed abstinence in free-choice drinking rhesus monkeys.

    PubMed

    Kornet, M; Goosen, C; Van Ree, J M

    1991-01-01

    Relapse into problematic alcohol drinking is a serious problem in the treatment of alcoholism. Free-choice drinking rhesus monkeys show relapse-like behaviour after imposed abstinence of alcohol, by immediately reinitiating ethanol intake at an increased level. The relapse-like behaviour of the monkeys seems not induced by physical withdrawal, but rather argues for a resistance to extinction of ethanol-reinforced behaviour. It has been suggested that endogenous opioids play a role in the positive reinforcing effect of ethanol. In this study, the effect of the opiate antagonist naltrexone was investigated in eight adult male rhesus monkeys (Macaca mulatta) who had about 1 year experience with alcohol drinking, under two conditions: 1) (expt 1) during continuous and concurrent supply of drinking water and two ethanol/water solutions (16% and 32% (v/v], and 2) (expt 2) after 2 days of alcohol abstinence. In both experiments, each monkey received six doses of naltrexone (0.02, 0.06, 0.17, 0.5, 1.0, 1.5 mg.kg-1); each dose was paired with a placebo injection (im) in a cross-over design. Consumption was measured from 16.00 hours in the afternoon (30 min after injection) to 9.00 hours the next morning. In experiment 1 naltrexone reduced total net ethanol intake in a graded dose-dependent manner. The effect of naltrexone was apparent shortly after injection, and lasted until the following day. Consumption of drinking water was reduced only shortly after injection. In expt 2, reduction of net ethanol intake was largely restricted to the first few hours of reinitiation of alcohol drinking, i.e. the period in which the abstinence-induced increase was manifest. Consumption of drinking water was not affected by naltrexone. Naltrexone hardly influenced consumption of the non-preferred ethanol solution of 32%. It is postulated that the opioid modulation specifically interacted with positively reinforced behaviour. In expt 2 naltrexone reduced ethanol intake at a lower dose (0

  19. The Effect of Combination Oral Contraceptives on Smoking-Related Symptomatology during Short-Term Smoking Abstinence

    PubMed Central

    Hinderaker, Katie; Tosun, Nicole; al'Absi, Mustafa; Hatsukami, Dorothy; Allen, Sharon S.

    2014-01-01

    Although an estimated 25% of premenopausal smokers report using oral contraceptives (OC), little is known about how OC use may influence smoking cessation. The purpose of this study was to examine the difference in smoking-related symptomatology during acute smoking abstinence between women on a standardized combination OC (Tri-Sprintec ™) compared to women not on OCs (no-OC). Participants were women aged 18-40 who smoked ≥5 cigarettes/day and reported regular menstrual cycles. Using a controlled cross-over design, participants completed two six-day testing weeks: Low Progesterone Week (LPW; Follicular (F) phase in no-OC or 1st week of pills in OC) and High Progesterone Week (HPW; Luteal (L) phase in no-OC or 3rd week of pills in OC). Each testing week included daily assessment of symptomatology and biochemical confirmation of smoking status. During smoking abstinence, the OC group (n=14) reported significantly lower levels of positive affect (21.56±7.12 vs. 24.57±6.46; β=3.63, p=0.0323) than the no-OC group (n=28). Further significant interactions between group and testing week were observed as follows: Smoking satisfaction was higher during LPW in the OC group (LPW: 4.29±1.30 vs. HPW: 4.10±1.37) but higher during HPW in the no-OC group (LPW: 3.91 ± 1.30 vs. HPW: 4.23 ± 1.30; β=-0.5499, p<0.0001). Similar interactions were noted in negative affect and psychological reward of smoking. These results suggest that women on OCs may have different patterns of smoking-related symptomatology during short-term smoking abstinence as compared to women not on OCs. Additional work is needed to examine how this may affect smoking cessation efforts. PMID:25452059

  20. The effect of combination oral contraceptives on smoking-related symptomatology during short-term smoking abstinence.

    PubMed

    Hinderaker, Katie; Allen, Alicia M; Tosun, Nicole; al'Absi, Mustafa; Hatsukami, Dorothy; Allen, Sharon S

    2015-02-01

    Although an estimated 25% of premenopausal smokers report using oral contraceptives (OC), little is known about how OC use may influence smoking cessation. The purpose of this study was to examine the difference in smoking-related symptomatology during acute smoking abstinence between women on a standardized combination OC (Tri-Sprintec(™)) compared to women not on OCs (no-OC). Participants were women aged 18-40 who smoked ≥5 cigarettes/day and reported regular menstrual cycles. Using a controlled cross-over design, participants completed two six-day testing weeks: Low Progesterone Week (LPW; Follicular (F) phase in no-OC or 1st week of pills in OC) and High Progesterone Week (HPW; Luteal (L) phase in no-OC or 3rd week of pills in OC). Each testing week included daily assessment of symptomatology and biochemical confirmation of smoking status. During smoking abstinence, the OC group (n=14) reported significantly lower levels of positive affect (21.56±7.12 vs. 24.57±6.46; β=3.63, p=0.0323) than the no-OC group (n=28). Further significant interactions between group and testing week were observed as follows: Smoking satisfaction was higher during LPW in the OC group (LPW: 4.29±1.30 vs. HPW: 4.10±1.37) but higher during HPW in the no-OC group (LPW: 3.91±1.30 vs. HPW: 4.23±1.30; β=-0.5499, p<0.0001). Similar interactions were noted in negative affect and psychological reward of smoking. These results suggest that women on OCs may have different patterns of smoking-related symptomatology during short-term smoking abstinence as compared to women not on OCs. Additional work is needed to examine how this may affect smoking cessation efforts. PMID:25452059

  1. 31 CFR 544.202 - Effect of transfers violating the provisions of this part.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY WEAPONS OF MASS DESTRUCTION PROLIFERATORS SANCTIONS REGULATIONS Prohibitions § 544.202 Effect of transfers violating...

  2. 31 CFR 544.202 - Effect of transfers violating the provisions of this part.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY WEAPONS OF MASS DESTRUCTION PROLIFERATORS SANCTIONS REGULATIONS Prohibitions § 544.202 Effect of transfers violating...

  3. 31 CFR 544.202 - Effect of transfers violating the provisions of this part.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY WEAPONS OF MASS DESTRUCTION PROLIFERATORS SANCTIONS REGULATIONS Prohibitions § 544.202 Effect of transfers violating...

  4. 31 CFR 544.202 - Effect of transfers violating the provisions of this part.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY WEAPONS OF MASS DESTRUCTION PROLIFERATORS SANCTIONS REGULATIONS Prohibitions § 544.202 Effect of transfers violating...

  5. 31 CFR 544.202 - Effect of transfers violating the provisions of this part.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY WEAPONS OF MASS DESTRUCTION PROLIFERATORS SANCTIONS REGULATIONS Prohibitions § 544.202 Effect of transfers violating...

  6. Observation of a Large Atomic Parity Violation Effect in Ytterbium

    SciTech Connect

    Tsigutkin, K.; Dounas-Frazer, D.; Family, A.; Stalnaker, J. E.; Yashchuk, V. V.; Budker, D.

    2009-08-14

    Atomic parity violation has been observed in the 6s{sup 2} {sup 1}S{sub 0}->5d6s {sup 3}D{sub 1} 408-nm forbidden transition of ytterbium. The parity-violating amplitude is found to be 2 orders of magnitude larger than in cesium, where the most precise experiments to date have been performed. This is in accordance with theoretical predictions and constitutes the largest atomic parity-violating amplitude yet observed. This also opens the way to future measurements of neutron distributions and anapole moments by comparing parity-violating amplitudes for various isotopes and hyperfine components of the transition.

  7. Online Activities for Enhancing Sex Education Curricula: Preliminary Evidence on the Effectiveness of the Abstinence and Contraception Education Storehouse

    PubMed Central

    Raghupathy, Shobana; Klein, Charles; Card, Josefina

    2013-01-01

    The purpose of this research was to conduct a preliminary evaluation of the Abstinence and Contraception Education Storehouse (ACES), a digital, classroom-based resource designed to supplement existing sex education curricula with highly interactive materials such as video clips, multimedia polls and quizzes, and audiovisual demonstrations. 335 students ages 14–19 were randomly assigned to an ACES–based (treatment) or a standard (control) sex education curriculum. Data were collected at the onset of the intervention and 3-months after the completion of the intervention. Preliminary results were highly encouraging, with ACES participants who were sexually initiated at baseline reporting at the 3-month follow-up significant reductions in the number of times they had sex in the past four weeks. Both sexually initiated and non-sexually initiated youth who experienced the ACES curriculum also demonstrated greater intent to abstain from the sex during the follow-up period than those in the control group. PMID:24078799

  8. Online Activities for Enhancing Sex Education Curricula: Preliminary Evidence on the Effectiveness of the Abstinence and Contraception Education Storehouse.

    PubMed

    Raghupathy, Shobana; Klein, Charles; Card, Josefina

    2013-01-01

    The purpose of this research was to conduct a preliminary evaluation of the Abstinence and Contraception Education Storehouse (ACES), a digital, classroom-based resource designed to supplement existing sex education curricula with highly interactive materials such as video clips, multimedia polls and quizzes, and audiovisual demonstrations. 335 students ages 14-19 were randomly assigned to an ACES-based (treatment) or a standard (control) sex education curriculum. Data were collected at the onset of the intervention and 3-months after the completion of the intervention. Preliminary results were highly encouraging, with ACES participants who were sexually initiated at baseline reporting at the 3-month follow-up significant reductions in the number of times they had sex in the past four weeks. Both sexually initiated and non-sexually initiated youth who experienced the ACES curriculum also demonstrated greater intent to abstain from the sex during the follow-up period than those in the control group. PMID:24078799

  9. Nuclear Parity-Violation in Effective Field Theory

    SciTech Connect

    Shi-Lin Zhu; C.M. Maekawa; B.R. Holstein; M.J. Ramsey-Musolf; U van Kolck

    2005-02-21

    We reformulate the analysis of nuclear parity-violation (PV) within the framework of effective field theory (EFT). To order Q, the PV nucleon-nucleon (NN) interaction depends on five a priori unknown constants that parameterize the leading-order, short-range four-nucleon operators. When pions are included as explicit degrees of freedom, the potential contains additional medium- and long-range components parameterized by PV piNN couplings. We derive the form of the corresponding one- and two-pion-exchange potentials. We apply these considerations to a set of existing and prospective PV few-body measurements that may be used to determine the five independent low-energy constants relevant to the pionless EFT and the additional constants associated with dynamical pions. We also discuss the relationship between the conventional meson-exchange framework and the EFT formulation, and argue that the latter provides a more general and systematic basis for analyzing nuclear PV.

  10. The effect of follow-up inspections on critical violations identified during restaurant inspections.

    PubMed

    Waters, A Blake; VanDerslice, James; Porucznik, Christina; Kim, Jaewhan; Durrant, Lynne; DeLegge, Royal

    2015-06-01

    Follow-up inspections are recommended by the Food and Drug Administration as a tool to verify corrections to violations cited during restaurant inspections. The effectiveness of follow-up inspections as a tool in reducing critical violations is unknown, however. The purpose of the authors' study was to assess whether a serious violation that leads to a follow-up inspection reduces the probability of specific critical violations occurring during the next routine inspection. Outcome measures included poor personal hygiene, improper holding temperatures, substandard equipment cleanliness, potential cross contamination, and improper sanitizer concentration. The risk of having a violation increased for all targeted critical violations during inspections conducted after a follow-up inspection compared to restaurant inspections without a prior follow-up, when adjusting for restaurant type, inspector experience, and season. PMID:26058216

  11. Chronic escalating cocaine exposure, abstinence/withdrawal, and chronic re-exposure: effects on striatal dopamine and opioid systems in C57BL/6J mice.

    PubMed

    Zhang, Yong; Schlussman, Stefan D; Rabkin, Jacqui; Butelman, Eduardo R; Ho, Ann; Kreek, Mary Jeanne

    2013-04-01

    Cocaine addiction is a chronic relapsing disease with periods of chronic escalating self-exposure, separated by periods of abstinence/withdrawal of varying duration. Few studies compare such cycles in preclinical models. This study models an "addiction-like cycle" in mice to determine neurochemical/molecular alterations that underlie the chronic, relapsing nature of this disease. Groups of male C57BL/6J mice received acute cocaine exposure (14-day saline/14-day withdrawal/13-day saline + 1-day cocaine), chronic cocaine exposure (14 day cocaine) or chronic re-exposure (14-day cocaine/14-day withdrawal/14-day cocaine). Escalating-dose binge cocaine (15-30 mg/kg/injection × 3/day, i.p. at hourly intervals) or saline (14-day saline) was administered, modeling initial exposure. In "re-exposure" groups, after a 14-day injection-free period (modeling abstinence/withdrawal), mice that had received cocaine were re-injected with 14-day escalating-dose binge cocaine, whereas controls received saline. Microdialysis was conducted on the 14th day of exposure or re-exposure to determine striatal dopamine content. Messenger RNA levels of preprodynorphin (Pdyn), dopamine D1 (Drd1) and D2 (Drd2) in the caudate putamen were determined by real-time PCR. Basal striatal dopamine levels were lower in mice after 14-day escalating exposure or re-exposure than in those in the acute cocaine group and controls. Pdyn mRNA levels were higher in the cocaine groups than in controls. Long-term adaptation was observed across the stages of this addiction-like cycle, in that the effects of cocaine on dopamine levels were increased after re-exposure compared to exposure. Changes in striatal dopaminergic responses across chronic escalating cocaine exposure and re-exposure are a central feature of the neurobiology of relapsing addictive states. PMID:23164614

  12. Relativistic gravity and parity-violating nonrelativistic effective field theories

    NASA Astrophysics Data System (ADS)

    Wu, Chaolun; Wu, Shao-Feng

    2015-06-01

    We show that the relativistic gravity theory can offer a framework to formulate the nonrelativistic effective field theory in a general coordinate invariant way. We focus on the parity violating case in 2 +1 dimensions which is particularly appropriate for the study on quantum Hall effects and chiral superfluids. We discuss how the nonrelativistic spacetime structure emerges from relativistic gravity. We present covariant maps and constraints that relate the field contents in the two theories, which also serve as the holographic dictionary in the context of gauge/gravity duality. A low energy effective action for fractional quantum Hall states is constructed, which captures universal geometric properties and generates nonuniversal corrections systematically. We give another holographic example with dyonic black brane background to calculate thermodynamic and transport properties of strongly coupled nonrelativistic fluids in magnetic field. In particular, by identifying the shift function in the gravity as a minus of guiding center velocity, we obtain the Hall viscosity with its relation to Landau orbital angular momentum density proportional to Wen-Zee shift. Our formalism has a good projection to lowest Landau level.

  13. An effective field theory for forward scattering and factorization violation

    NASA Astrophysics Data System (ADS)

    Rothstein, Ira Z.; Stewart, Iain W.

    2016-08-01

    Starting with QCD, we derive an effective field theory description for forward scattering and factorization violation as part of the soft-collinear effective field theory (SCET) for high energy scattering. These phenomena are mediated by long distance Glauber gluon exchanges, which are static in time, localized in the longitudinal distance, and act as a kernel for forward scattering where | t| ≪ s. In hard scattering, Glauber gluons can induce corrections which invalidate factorization. With SCET, Glauber exchange graphs can be calculated explicitly, and are distinct from graphs involving soft, collinear, or ultrasoft gluons. We derive a complete basis of operators which describe the leading power effects of Glauber exchange. Key ingredients include regulating light-cone rapidity singularities and subtractions which prevent double counting. Our results include a novel all orders gauge invariant pure glue soft operator which appears between two collinear rapidity sectors. The 1-gluon Feynman rule for the soft operator coincides with the Lipatov vertex, but it also contributes to emissions with ≥ 2 soft gluons. Our Glauber operator basis is derived using tree level and one-loop matching calculations from full QCD to both SCETII and SCETI. The one-loop amplitude's rapidity renormalization involves mixing of color octet operators and yields gluon Reggeization at the amplitude level. The rapidity renormalization group equation for the leading soft and collinear functions in the forward scattering cross section are each given by the BFKL equation. Various properties of Glauber gluon exchange in the context of both forward scattering and hard scattering factorization are described. For example, we derive an explicit rule for when eikonalization is valid, and provide a direct connection to the picture of multiple Wilson lines crossing a shockwave. In hard scattering operators Glauber subtractions for soft and collinear loop diagrams ensure that we are not sensitive to

  14. Parton Charge Symmetry Violation: Electromagnetic Effects and W Production Asymmetries

    SciTech Connect

    J.T. Londergan; D.P. Murdock; A.W. Thomas

    2006-04-14

    Recent phenomenological work has examined two different ways of including charge symmetry violation in parton distribution functions. First, a global phenomenological fit to high energy data has included charge symmetry breaking terms, leading to limits on the magnitude of parton charge symmetry breaking. In a second approach, two groups have included the coupling of partons to photons in the QCD evolution equations. One possible experiment that could search for isospin violation in parton distributions is a measurement of the asymmetry in W production at a collider. In this work we include both of the postulated sources of parton charge symmetry violation. We show that, given charge symmetry violation of a magnitude consistent with existing high energy data, the expected W production asymmetries would be quite small, generally less than one percent.

  15. Cigarette abstinence impairs memory and metacognition despite administration of 2 mg nicotine gum.

    PubMed

    Kelemen, William L; Fulton, Erika K

    2008-12-01

    The authors assessed the effects of cigarette abstinence (nonabstinent vs. minimum 8 hours abstinent) and nicotine gum (0 mg vs. 2 mg nicotine) on sustained attention, free recall, and metacognition using a within-subjects design. Moderate smokers (10 women and 22 men) received one training session followed by four test sessions on consecutive days. Nicotine gum improved sustained attention in both abstinent and nonabstinent states, but had no significant effect on predicted or actual recall levels. Cigarette abstinence significantly impaired free recall and reduced the magnitude of participants' predictions of their own performance. In addition, participants were significantly more overconfident about their future memory when abstinent. Thus, nicotine gum can improve smokers' performance in basic aspects of cognition (e.g., sustained attention) but may not alleviate the detrimental effects of cigarette abstinence on higher-level processes such memory and metacognition. PMID:19086773

  16. Reinforcing value of smoking relative to physical activity and the effects of physical activity on smoking abstinence symptoms among young adults

    PubMed Central

    Audrain-McGovern, Janet; Strasser, Andrew A.; Ashare, Rebecca; Wileyto, E. Paul

    2015-01-01

    This study sought to evaluate whether individual differences in the reinforcing value of smoking relative to physical activity (RRVS) moderated the effects of physical activity on smoking abstinence symptoms in young adult smokers. The repeated measures within-subjects design included daily smokers (n=79) 18–26 years old. RRVS was measured with a validated behavioral choice task. On two subsequent visits, participants completed self-report measures of craving, withdrawal, mood, and affective valence before and after they engaged in passive sitting or a bout of physical activity. RRVS did not moderate any effects of physical activity (p’s > .05). Physical activity compared to passive sitting predicted decreased withdrawal symptoms (β=−5.23, CI= −6.93, −3.52; p<0.001), negative mood (β=−2.92, CI= −4.13, −1.72; p<0.001), and urge to smoke (β=−7.13, CI= −9.39, −4.86; p<0.001). Also, physical activity compared to passive sitting predicted increased positive affect (β=3.08, CI= 1.87, 4.28; p<0.001) and pleasurable feelings (β=1.07, CI= 0.58, 1.55; p<0.001), and greater time to first cigarette during the ad-libitum smoking period (β=211.76, CI= 32.54, 390.98; p=0.02). RRVS predicted higher levels of pleasurable feelings (β=0.22, CI= 0.01 – 0.43, p=0.045), increased odds of smoking versus remaining abstinent during the ad-libitum smoking period (β=0.04, CI= 0.01, 0.08; p=0.02), and reduced time to first cigarette (β=−163.00, CI = −323.50, −2.49; p=0.047). Regardless of the RRVS, physical activity produces effects that may aid smoking cessation in young adult smokers. However, young adult smokers who have a higher RRVS will be less likely to choose to engage physical activity, especially when smoking is an alternative. PMID:26348158

  17. Civil Protective Order Outcomes: Violations and Perceptions of Effectiveness

    ERIC Educational Resources Information Center

    Logan, T. K.; Walker, Robert

    2009-01-01

    This study examined protective order (PO) outcomes for a period of 12 months for 698 women from multiple jurisdictions. Overall, results indicate that 2 out of 5 women did not experience violence after the PO was issued; however, 3 out of 5 women did experience ongoing violence. Two key risk factors were associated with PO violations and are…

  18. Sex Differences in Time Perception During Smoking Abstinence

    PubMed Central

    Kable, Joseph W.

    2015-01-01

    Introduction: Nicotine withdrawal leads to impulsive decision-making, which reflects a preference for smaller, immediate rewards and often prompts a relapse to smoking. The mechanism by which nicotine withdrawal leads to impulsive decision-making is not well known. An essential dimension of decision-making is time perception. Impulsive decisions reflect intolerance of temporal delays and the perception that time is passing more slowly. Sex may be an important factor in impulsive decision-making and time perception, but no studies have investigated whether sex moderates the effects of nicotine withdrawal on impulsive decision-making and time perception. Methods: Thirty-three (12 female) adult smokers completed 2 laboratory sessions: following 24-hr abstinence and once smoking-as-usual (order counterbalanced, abstinence biochemically verified). Participants completed 2 time perception tasks, a decision-making task, and self-report measures of craving, withdrawal, and mood. Results: During time reproduction, males overestimated time during abstinence compared to smoking, whereas there was no session effect for females. On the time discrimination task, smokers were less accurate during abstinence, and this effect tended to be stronger among females. In general, males had higher discounting rates compared with females, but there was no effect of abstinence. Conclusions: The current data suggest that the effect of abstinence on time perception may be stronger in males and that males generally exhibit steeper delay discounting rates. Time perception may be an important mechanism in smoking abstinence. Our future work will investigate the role of time perception in smoking relapse and whether this is moderated by sex. PMID:25762755

  19. The discovery reach of CP violation in neutrino oscillation with non-standard interaction effects

    NASA Astrophysics Data System (ADS)

    Rahman, Zini; Dasgupta, Arnab; Adhikari, Rathin

    2015-06-01

    We have studied the CP violation discovery reach in a neutrino oscillation experiment with superbeam, neutrino factory and monoenergetic neutrino beam from the electron capture process. For NSI satisfying model-dependent bound for shorter baselines (like CERN-Fréjus set-up) there is insignificant effect of NSI on the the discovery reach of CP violation due to δ. Particularly, for the superbeam and neutrino factory we have also considered relatively longer baselines for which there could be significant NSI effects on CP violation discovery reach for higher allowed values of NSI. For the monoenergetic beam only shorter baselines are considered to study CP violation with different nuclei as neutrino sources. Interestingly for non-standard interactions—{{\\varepsilon }eμ } and {{\\varepsilon }eτ } of neutrinos with matter during propagation in longer baselines in the superbeam, there is the possibility of better discovery reach of CP violation than that with only Standard Model interactions of neutrinos with matter. For complex NSI we have shown the CP violation discovery reach in the plane of Dirac phase δ and NSI phase {{φ }ij}. The CP violation due to some values of δ remain unobservable with present and near future experimental facilities in the superbeam and neutrino factory. However, in the presence of some ranges of off-diagonal NSI phase values there are some possibilities of discovering total CP violation for any {{δ }CP} value even at 5σ confidence level for neutrino factory. Our analysis indicates that for some values of NSI phases total CP violation may not be at all observable for any values of δ. Combination of shorter and longer baselines could indicate in some cases the presence of NSI. However, in general for NSIs ≲ 1 the CP violation discovery reach is better in neutrino factory set-ups. Using a neutrino beam from the electron capture process for nuclei 50110Sn and 152Yb, we have shown the discovery reach of CP violation in a neutrino

  20. Tobacco withdrawal symptoms mediate motivation to reinstate smoking during abstinence.

    PubMed

    Aguirre, Claudia G; Madrid, Jillian; Leventhal, Adam M

    2015-08-01

    Withdrawal-based theories of addiction hypothesize that motivation to reinstate drug use following acute abstinence is mediated by withdrawal symptoms. Experimental tests of this hypothesis in the tobacco literature are scant and may be subject to methodological limitations. This study utilized a robust within-subject laboratory experimental design to investigate the extent to which composite tobacco withdrawal symptomatology level and 3 unique withdrawal components (i.e., low positive affect, negative affect, and urge to smoke) mediated the effect of smoking abstinence on motivation to reinstate smoking. Smokers (≥10 cigarettes per day; N = 286) attended 2 counterbalanced sessions at which abstinence duration was differentially manipulated (1 hr vs. 17 hr). At both sessions, participants reported current withdrawal symptoms and subsequently completed a task in which they were monetarily rewarded proportional to the length of time they delayed initiating smoking, with shorter latency reflecting stronger motivation to reinstate smoking. Abstinence reduced latency to smoking initiation and positive affect and increased composite withdrawal symptom level, urge, and negative affect. Abstinence-induced reductions in latency to initiating smoking were mediated by each withdrawal component, with stronger effects operating through urge. Combined analyses suggested that urge, negative affect, and low positive affect operate through empirically unique mediational pathways. Secondary analyses suggested similar effects on smoking quantity, few differences among specific urge and affect subtypes, and that dependence amplifies some abstinence effects. This study provides the first experimental evidence that within-person variation in abstinence impacts motivation to reinstate drug use through withdrawal. Urge, negative affect, and low positive affect may reflect unique withdrawal-mediated mechanisms underlying tobacco addiction. PMID:25961814

  1. The Ethics of Abstinence-Only and Abstinence-Plus Sexuality Education.

    ERIC Educational Resources Information Center

    Wiley, David C.

    2002-01-01

    Highlights some of the ethical dilemmas present in the debate over abstinence-only and abstinence-plus sexuality education in the schools, discussing issues related to: morality, ethics, and values; limitations to codes of ethics; questions about abstinence-only sexuality education; ethics and abstinence- only sexuality education; and sexuality…

  2. Smoking Abstinence, Eating Style, and Food Intake.

    ERIC Educational Resources Information Center

    Duffy, Joanne; Hall, Sharon M.

    1988-01-01

    Administered the Eating Inventory and the Profile of Mood States (POMS) to smoking subjects assigned to cigarette abstinence or to continued smoking. Found abstinent smokers with high Disinhibition Scale scores overate more than did nonabstinent smokers or abstinent smokers with lower scores when participating in a subsequent ice cream tasting…

  3. Two destructive effects of decoherence on Bell inequality violation

    SciTech Connect

    Levkovich-Maslyuk, F. L.

    2009-05-15

    We consider a system of two spin-(1/2) particles, initially in an entangled Bell state. If one of the particles is interacting with an environment (e.g., a collection of N independent spins), the two-particle system undergoes decoherence. Using a simple model of decoherence, we show that this process has two consequences. First, the maximal amount by which the Clauser-Horne-Shimony-Holt inequality is violated decays to zero. Second, the set of directions of measurement for which the inequality is violated is reduced in the course of decoherence. The volume of that set is bounded above by constx|r|{sup 2}, where r is the decoherence factor. We obtain similar results for the case when each of the two particles is in interaction with a separate environment.

  4. The Effect of Prenatal Alcohol Co-Exposure on Neonatal Abstinence Syndrome in Infants Born to Mothers in Opioid Maintenance Treatment

    PubMed Central

    Kreitinger, Christine; Gutierrez, Hilda; Hamidovic, Ajna; Schmitt, Cheryl; Sarangarm, Preeyaporn; Rayburn, William F.; Leeman, Lawrence; Bakhireva, Ludmila N.

    2015-01-01

    Objective This study examined the effects of prenatal alcohol exposure (PAE) on the incidence and severity of neonatal abstinence syndrome (NAS). Study design For this pilot study, 70 pregnant women on opioid maintenance therapy (OMT) were recruited from a perinatal substance abuse clinic. Subjects were categorized into three study groups based on the timing of alcohol use during pregnancy as assessed by repeated self-reported measures and a comprehensive panel of ethanol biomarkers. NAS outcomes included: duration of hospital stay, the need for pharmacological treatment of NAS, newborn age at the initiation of NAS treatment, duration of treatment, and cumulative methadone dose administered. Results The study included a large proportion of ethnic minorities (81.4% Hispanic, 5.7% American Indian), women with less than a high school education (52.2%) and unplanned pregnancy (82.9%). In multivariate analysis, PAE was not associated with NAS outcomes; however, one newborn diagnosed with Fetal Alcohol Syndrome demonstrated much more severe NAS compared to other PAE infants. Interestingly, 3rd trimester PAE was associated with a higher prevalence of microcephaly (62.5%) compared to the PAE abstaining group (36.8%; p=0.08). Conclusion In this study, PAE was not associated with NAS severity; however, further examination in a larger study is needed. PMID:25758627

  5. Maintenance Sessions Prolong Cigarette Abstinence.

    ERIC Educational Resources Information Center

    Brandon, Thomas H.; And Others

    Recent smoking treatment programs have shifted emphasis from initial cessation rates to long-term abstinence, with aversion therapy and coping response training having had the most success. A smoking cessation treatment consisting of rapid smoking and behavioral counseling was supplemented with two maintenance treatments. After completing the…

  6. [Maintaining abstinence after alcohol detoxification].

    PubMed

    Batel, Philippe; Balester-Mouret, Sylvain

    2006-05-31

    "To quit drinking" is not the panacea of alcohol dependence treatment; it is only its first step. Abstinence should be considered more as a mean than a purpose of the after-withdrawal cares. The frequent resistance of the alcoholic patient to undertake in a long term abstinence can be by-passed by suggesting to fix himself renewable terms for periods during which he feels rather confident to raise the bet of a "most accomplished possible" abstinence. To facilitate the realization and the preservation of this abstinence in the best conditions (potentiation of the profits and minimization of the difficulties), a "therapeutic menu" will be proposed to the patient besides a "minimum plan" containing a medical follow-up over one year, with variable frequency of visits according to the evolution and the prescription of one or two anti-craving drugs registered. Psychotherapies using different techniques as Cognitive Behavioural Therapy, group therapy or psychoanalysis could be proposed after a necessary clarification to the patients of the mechanism of action of each and the waited profits. In the final, two thirds of the patients with alcohol dependence fire in one year a profit of their treatments; the practitioner takes, actually, no risk and should propose systematically a project to the only 20% of them who come to consult him. PMID:16836206

  7. Impact of Lorentz violation on the Klein tunneling effect

    NASA Astrophysics Data System (ADS)

    Xiao, Zhi

    2016-06-01

    In this paper, we discuss the impact of a tiny Lorentz violating bμ term on the one-dimensional motion of a Dirac particle scattering on a rectangular barrier. We assume the experiment is done in a particular inertial frame, where the components of bμ are assumed constants. The results show that Lorentz violation modification to the transmission rate depends on the nature of bμ. For a purely time-like bμ=(b ,0 → ) , the transmission rate and resonant tunneling frequency are essentially unaltered compared with the Lorentz invariant counterparts, though the dispersion relation is slightly modified. For a space-like or light-like bμ , the incoming electron is polarized, and the Lorentz violation induced resonant frequency shift depends on the polarization. In fact, for certain special cases, like bμ=b (0 ,e→ Z) or bμ=b (1 ,e→ Z) , the absolute frequency difference between different helicity eigenstates with the same resonant number n is 2 b . In addition to being of theoretical interest in the high energy region, its quantum analogue may be experimentally realizable in other areas of physics, like graphene or optical lattices, and may generate some cross interests in both fields.

  8. Associations between Sexual Abstinence Ideals, Religiosity, and Alcohol Abstinence: A Longitudinal Study of Finnish Twins

    PubMed Central

    Winter, Torsten; Karvonen, Sakari; Rose, Richard J.

    2016-01-01

    We analyzed prevalence and stability of attitudes endorsing sexual abstinence ideals from late adolescence into early adulthood and studied associations of these attitudes with religiosity and alcohol abstinence in a sexually liberal Nordic society. Our population-based sample of Finnish twins permitted comparisons of co-twins concordant for religiosity but discordant for drinking to evaluate the association of sexual abstinence ideals with alcohol abstinence, controlling for household environment. From age 17 to 24, endorsement of sexual abstinence as a romantic ideal declined from 25% to 15%. Religiosity and alcohol abstinence correlated, both separately and together, with endorsing sexual abstinence. Abstinence ideals were associated with literal belief in fundamental tenets of the Bible. The association of sexual abstinence ideals with alcohol abstinence was confirmed in within-family comparisons of co-twins discordant for drinking but concordant for religiosity. Alcohol-abstinent twins were significantly more likely than their non-alcohol-abstinent twin siblings to endorse sexual abstinence ideals; that result suggests the association of sexual abstinence ideals with abstaining from alcohol is not explained by unmeasured confounds in familial background and structure. Our longitudinal results and analyses of discordant twins suggest that attitudes toward sexual abstinence ideals are embedded within other conservative attitudes and behaviors. PMID:23301620

  9. Effect of violating the traffic light rule in the Biham-Middleton-Levine traffic flow model

    NASA Astrophysics Data System (ADS)

    Ding, Zhong-Jun; Jiang, Rui; Li, Ming; Li, Qi-Lang; Wang, Bing-Hong

    2012-09-01

    This paper studies the effect of violating the traffic light rule in the Biham-Middleton-Levine (BML) traffic flow model. It is assumed that there are two kinds of drivers: normal drivers obey the traffic light rule and violators disobey it. Simulation results show that although the existence of violators increases the average velocity in the free-flowing phase, it decreases the threshold from free-flowing phase to jam. With the presence of violators, a new kind of configuration with stripe slopes -2 and -1/2 has been found in the free-flowing phase. We have developed an analytical investigation which successfully predicts the average velocity in the free-flowing phase. A phase separation phenomenon, where jams and freely flowing traffic coexist, has been found in the intermediate car density range. The mechanism of the phase separation has been illustrated.

  10. Exercise during early, but not late abstinence, attenuates subsequent relapse vulnerability in a rat model.

    PubMed

    Beiter, R M; Peterson, A B; Abel, J; Lynch, W J

    2016-01-01

    Exercise has shown promise as a nonpharmacological intervention for addiction, with evidence suggesting a potential utility for relapse prevention. In humans, exercise as an intervention is typically introduced well after the initiation of abstinence, yet neurobiological data from preclinical studies suggest that it may be more effective if initiated during early abstinence. Here, using rat models, we determined whether the beneficial effects of exercise on relapse vulnerability depends on when exercise is first initiated, during early versus late abstinence. Once rats (n=47) acquired cocaine self-administration, they were given 24-h access to cocaine (1.5 mg/kg per infusion) under a discrete trial procedure (four infusions per hour) for 10 days. The rats then began a 14-day abstinence period in which they had access (2 h per day) to a locked wheel throughout abstinence (sedentary) or an unlocked wheel during early (days 1-7), late (days 8-14) or throughout (days 1-14) abstinence (n=10-14 per group). Cocaine seeking, as assessed under an extinction/cued-induced reinstatement procedure, was examined on day 15 of abstinence. Exercise beginning during early abstinence robustly attenuated subsequent cocaine seeking, and this effect persisted even when exercise ended on the seventh day of abstinence. In contrast, exercise during late abstinence was not effective and these animals displayed high levels of cocaine seeking similar to those observed in sedentary animals. These results indicate that the timing of exercise availability differentially impacts cocaine seeking with results suggesting that exercise during early, but not late, abstinence may provide long-term protection against cocaine relapse. PMID:27115123

  11. Exercise during early, but not late abstinence, attenuates subsequent relapse vulnerability in a rat model

    PubMed Central

    Beiter, R M; Peterson, A B; Abel, J; Lynch, W J

    2016-01-01

    Exercise has shown promise as a nonpharmacological intervention for addiction, with evidence suggesting a potential utility for relapse prevention. In humans, exercise as an intervention is typically introduced well after the initiation of abstinence, yet neurobiological data from preclinical studies suggest that it may be more effective if initiated during early abstinence. Here, using rat models, we determined whether the beneficial effects of exercise on relapse vulnerability depends on when exercise is first initiated, during early versus late abstinence. Once rats (n=47) acquired cocaine self-administration, they were given 24-h access to cocaine (1.5 mg/kg per infusion) under a discrete trial procedure (four infusions per hour) for 10 days. The rats then began a 14-day abstinence period in which they had access (2 h per day) to a locked wheel throughout abstinence (sedentary) or an unlocked wheel during early (days 1–7), late (days 8–14) or throughout (days 1–14) abstinence (n=10–14 per group). Cocaine seeking, as assessed under an extinction/cued-induced reinstatement procedure, was examined on day 15 of abstinence. Exercise beginning during early abstinence robustly attenuated subsequent cocaine seeking, and this effect persisted even when exercise ended on the seventh day of abstinence. In contrast, exercise during late abstinence was not effective and these animals displayed high levels of cocaine seeking similar to those observed in sedentary animals. These results indicate that the timing of exercise availability differentially impacts cocaine seeking with results suggesting that exercise during early, but not late, abstinence may provide long-term protection against cocaine relapse. PMID:27115123

  12. Clinical Trial of Abstinence-Based Vouchers and Cognitive-Behavioral Therapy for Cannabis Dependence

    ERIC Educational Resources Information Center

    Budney, Alan J.; Moore, Brent A.; Rocha, Heath L.; Higgins, Stephen T.

    2006-01-01

    Ninety cannabis-dependent adults seeking treatment were randomly assigned to receive cognitive-behavioral therapy, abstinence-based voucher incentives, or their combination. Treatment duration was 14 weeks, and outcomes were assessed for 12 months post treatment. Findings suggest that (a) abstinence-based vouchers were effective for engendering…

  13. A Qualitative Evaluation of the Students of Service (SOS) Program for Sexual Abstinence in Louisiana

    ERIC Educational Resources Information Center

    Yoo, Seunghyun; Johnson, Carolyn C.; Rice, Janet; Manuel, Powlin

    2004-01-01

    Abstinence-only programs for preventing teen pregnancy are the only options in some states but are the programs of choice in others. Effectiveness data, however, are lacking. The SOS Adolescent Family Life Program (SOS), an abstinence-only teen pregnancy prevention program, was implemented in south central Louisiana. Peer mentoring with an…

  14. Randomized Trial of Prize-Based Reinforcement Density for Simultaneous Abstinence from Cocaine and Heroin

    ERIC Educational Resources Information Center

    Ghitza, Udi E.; Epstein, David H.; Schmittner, John; Vahabzadeh, Massoud; Lin, Jia-Ling; Preston, Kenzie L.

    2007-01-01

    To examine the effect of reinforcer density in prize-based abstinence reinforcement, heroin/cocaine users (N = 116) in methadone maintenance (100 mg/day) were randomly assigned to a noncontingent control group (NonC) or to 1 of 3 groups that earned prize draws for abstinence: manual drawing with standard prize density (MS) or computerized drawing…

  15. Computing the temperature dependence of effective CP violation in the standard model

    NASA Astrophysics Data System (ADS)

    Brauner, Tomáš; Taanila, Olli; Tranberg, Anders; Vuorinen, Aleksi

    2012-11-01

    CP violation in the standard model originates from the Cabibbo-Kobayashi-Maskawa mixing matrix. Upon integrating all fermions out of the theory, its effects are captured by a series of effective nonrenormalizable operators for the bosonic gauge and Higgs fields. We compute the CP-violating part of the effective action to the leading nontrivial, sixth order in the covariant gradient expansion as a function of temperature. In the limit of zero temperature, our result addresses the discrepancy between two independent calculations existing in the literature [1, 2]. We find that CP violation in the standard model is strongly suppressed at high temperature, but that at T ≲ 1GeV it may be relevant for certain scenarios of baryogenesis. We also identify a selected class of operators at the next, eighth order and discuss the convergence of the covariant gradient expansion.

  16. Subjective Social Status Predicts Smoking Abstinence Among Light Smokers

    PubMed Central

    Whembolua, Guy-Lucien; Davis, Julia T.; Reitzel, Lorraine R.; Guo, Hongfei; Thomas, Janet L.; Goldade, Kate R.; Okuyemi, Kola S.; Ahluwalia, Jasjit S.

    2015-01-01

    Objectives To determine if community subjective social status (SSS) predicted smoking abstinence through 26 weeks postrandomization among 755 African American light smokers of low SES (socioeconomic status). Methods Participants were enrolled in a double-blind, placebo-controlled, randomized clinical trial, which examined the efficacy of nicotine gum and counseling for smoking cessation. Results Results indicated that SSS predicted smoking abstinence over time [P=.046; odds ratio (OR) =1.075 (1.001–1.155)] after adjusting for covariates. Conclusions Further research is needed to understand the effects of community SSS on smoking cessation among heavy smokers and other ethnic groups. PMID:22584091

  17. Effect of Reinforcement Probability and Prize Size on Cocaine and Heroin Abstinence in Prize-Based Contingency Management

    ERIC Educational Resources Information Center

    Ghitza, Udi E.; Epstein, David H.; Schmittner, John; Vahabzadeh, Massoud; Lin, Jia-Ling; Preston, Kenzie L.

    2008-01-01

    Although treatment outcome in prize-based contingency management has been shown to depend on reinforcement schedule, the optimal schedule is still unknown. Therefore, we conducted a retrospective analysis of data from a randomized clinical trial (Ghitza et al., 2007) to determine the effects of the probability of winning a prize (low vs. high) and…

  18. When do fair procedures not matter? A test of the identity violation effect.

    PubMed

    Mayer, David M; Greenbaum, Rebecca L; Kuenzi, Maribeth; Shteynberg, Garriy

    2009-01-01

    Considerable research has demonstrated that fair procedures help improve reactions to decisions, a phenomenon known as the fair process effect. However, in the present research, the authors identify when and why objectively fair procedures (i.e., receiving voice) may not always improve justice perceptions. Findings from 2 studies (Ns = 108 and 277) yield support for the proposed identity violation effect, which posits that when an outcome violates a central aspect of one's self (i.e., personal and/or social identity), objectively fair procedures do not improve procedural and distributive justice perceptions. Further, consistent with the motivated reasoning hypothesis, the Voice x Identity Violation interaction on justice perceptions was mediated by participants' tendency to find a procedural flaw--namely, to doubt that opinions were considered before making the decision. (PsycINFO Database Record (c) 2009 APA, all rights reserved). PMID:19186901

  19. Time reversal invariance violating and parity conserving effects in neutron-deuteron scattering

    SciTech Connect

    Song, Young-Ho; Gudkov, Vladimir; Lazauskas, Rimantas

    2011-08-15

    Time reversal invariance violating and parity conserving effects for low-energy elastic neutron-deuteron scattering are calculated for meson exchange and effective field theory type potentials in a distorted wave-born approximation using realistic hadronic wave functions, obtained by solving three-body Faddeev equations in configuration space.

  20. Breastfeeding and abstinence among the Yoruba.

    PubMed

    Dow, T E

    1977-08-01

    Contemporary patterns of breastfeeding and postpartum abstinence among the Yoruba of Nigera are examined. Quite extensive periods of postpartum abstinence are still observed by most rural and poorer urban women to prolong breastfeeding and increase child survivorship. Differentials in duration of breastfeeding and abstinence relate to both socioeconomic factors and age, suggesting the likelihood of large future reductions. Implications for family planning prospects and policies are noted. PMID:888163

  1. The effect of chewing gum flavor on the negative affect associated with tobacco abstinence among dependent cigarette smokers.

    PubMed

    Cohen, Lee M; Collins, Frank L; Vanderveen, Joseph W; Weaver, Cameron C

    2010-11-01

    Many smokers relapse during cessation attempts due to increases in negative affect. Previous research has shown that chewing confectionary chewing gum appears to lessen the severity of acute nicotine withdrawal symptoms and help individuals who are trying to reduce smoking in part due to the flavor of the gum chewed. The current study compared the effects of three flavored gums to a No Gum Control during 48-hour cessation periods for young dependent smokers. Forty-nine smokers participated in three experimental conditions (peppermint, vanilla, and baked apple cardamom flavored gum) as well as a No Gum Control across four weeks while abstaining from smoking for 48-hours each week. Compared to the No Gum Control, participants in the Gum conditions reported lower levels of anxiety, dysphoria, and tension. Vanilla and baked apple cardamom flavored gum resulted in lower levels of negative affect while peppermint flavored gum was not different from the No Gum Control. These findings indicate that some flavors of gum are effective in reducing the negative affect associated with nicotine withdrawal and may serve as a valuable tool in helping smokers quit. PMID:20598808

  2. Strongly enhanced effects of Lorentz symmetry violation in highly charged ions

    NASA Astrophysics Data System (ADS)

    Safronova, Marianna; Dzuba, V. A.; Flambaum, V. V.; Porsev, S. G.; Pruttivarasin, T.; Hohensee, M. A.; Häffner, H.

    2016-05-01

    It has been suggested that Lorentz symmetry may be violated in theories aiming at unifying gravity with other fundamental interactions. While the energy scale of such strongly Lorentz symmetry-violating physics is much higher than that currently attainable by particle accelerators, the observable, but extremely small, Lorentz-violating effects may appear in low-energy experiments carried out with very high precision. In the atomic experiments testing local Lorentz invariance (LLI) of the electron motion in Coulomb potential of a nucleus, one searches for variations of the atomic energy levels when the orientation of the electronic wave function is rotated with respect to the standard reference frame. We carried out a systematic theoretical investigation of the sensitivity of a wide range of atomic systems to LLI violation. We find large sensitivities to LLI violating physics in Yb+ and a number of highly charged ions that should allow improvements of LLI tests in the electron-photon sector by several orders of magnitude.

  3. Texas Abstinence Educators' Self-Efficacy to Motivate Youth Sexual Abstinence

    ERIC Educational Resources Information Center

    Rasberry, Catherine N.; Goodson, Patricia; Buhi, Eric R.; Pruitt, B. E.; Wilson, Kelly; Suther, Sandra

    2007-01-01

    Authors examined self-efficacy to motivate abstinent behavior (among youth) in a sample of instructors teaching abstinence-only-until-marriage education in Texas (N = 104). Sixty-one percent of the sample had been trained/certified to teach abstinence education. Instructors (mostly female and White) were more confident motivating students to…

  4. Human rights violations against sex workers: burden and effect on HIV.

    PubMed

    Decker, Michele R; Crago, Anna-Louise; Chu, Sandra K H; Sherman, Susan G; Seshu, Meena S; Buthelezi, Kholi; Dhaliwal, Mandeep; Beyrer, Chris

    2015-01-10

    We reviewed evidence from more than 800 studies and reports on the burden and HIV implications of human rights violations against sex workers. Published research documents widespread abuses of human rights perpetrated by both state and non-state actors. Such violations directly and indirectly increase HIV susceptibility, and undermine effective HIV-prevention and intervention efforts. Violations include homicide; physical and sexual violence, from law enforcement, clients, and intimate partners; unlawful arrest and detention; discrimination in accessing health services; and forced HIV testing. Abuses occur across all policy regimes, although most profoundly where sex work is criminalised through punitive law. Protection of sex workers is essential to respect, protect, and meet their human rights, and to improve their health and wellbeing. Research findings affirm the value of rights-based HIV responses for sex workers, and underscore the obligation of states to uphold the rights of this marginalised population. PMID:25059943

  5. Exploration of possible quantum gravity effects with neutrinos II: Lorentz violation in neutrino propagation

    NASA Astrophysics Data System (ADS)

    Sakharov, Alexander; Ellis, John; Harries, Nicholas; Meregaglia, Anselmo; Rubbia, André

    2009-06-01

    It has been suggested that the interactions of energetic particles with the foamy structure of space-time thought to be generated by quantum-gravitational (QG) effects might violate Lorentz invariance, so that they do not propagate at a universal speed of light. We consider the limits that may be set on a linear or quadratic violation of Lorentz invariance in the propagation of energetic neutrinos, v/c = [1 ± (E/MvQG1)] or [1 ± (E/MvQG2)2], using data from supernova explosions and the OPERA long-baseline neutrino experiment.

  6. 31 CFR 589.202 - Effect of transfers violating the provisions of this part.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false Effect of transfers violating the provisions of this part. 589.202 Section 589.202 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY UKRAINE...

  7. 31 CFR 576.202 - Effect of transfers violating the provisions of this part.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 31 Money and Finance:Treasury 3 2012-07-01 2012-07-01 false Effect of transfers violating the provisions of this part. 576.202 Section 576.202 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY...

  8. 31 CFR 576.202 - Effect of transfers violating the provisions of this part.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false Effect of transfers violating the provisions of this part. 576.202 Section 576.202 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY...

  9. 31 CFR 576.202 - Effect of transfers violating the provisions of this part.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false Effect of transfers violating the provisions of this part. 576.202 Section 576.202 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY...

  10. 31 CFR 576.202 - Effect of transfers violating the provisions of this part.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false Effect of transfers violating the provisions of this part. 576.202 Section 576.202 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY...

  11. 31 CFR 558.202 - Effect of transfers violating the provisions of this part.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false Effect of transfers violating the provisions of this part. 558.202 Section 558.202 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY SOUTH...

  12. 31 CFR 535.203 - Effect of transfers violating the provisions of this part.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Effect of transfers violating the provisions of this part. 535.203 Section 535.203 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY IRANIAN ASSETS CONTROL REGULATIONS Prohibitions §...

  13. Time reversal invariance violating and parity conserving effects in proton-deuteron scattering

    NASA Astrophysics Data System (ADS)

    Song, Young-Ho; Lazauskas, Rimantas; Gudkov, Vladimir

    2016-06-01

    Time reversal invariance violating parity conserving (TVPC) effects are calculated for elastic proton-deuteron scattering with proton energies up to 2 MeV. The distorted-wave Born approximation is employed to estimate TVPC matrix elements, based on hadronic wave functions, obtained by solving three-body Faddeev-Merkuriev equations in configuration space with realistic potentials.

  14. 31 CFR 510.202 - Effect of transfers violating the provisions of this part.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false Effect of transfers violating the provisions of this part. 510.202 Section 510.202 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY NORTH...

  15. 31 CFR 510.202 - Effect of transfers violating the provisions of this part.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false Effect of transfers violating the provisions of this part. 510.202 Section 510.202 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY NORTH...

  16. 31 CFR 510.202 - Effect of transfers violating the provisions of this part.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 31 Money and Finance:Treasury 3 2012-07-01 2012-07-01 false Effect of transfers violating the provisions of this part. 510.202 Section 510.202 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY NORTH KOREA SANCTIONS REGULATIONS Prohibitions §...

  17. 31 CFR 595.202 - Effect of transfers violating the provisions of this part.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Effect of transfers violating the provisions of this part. 595.202 Section 595.202 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY...

  18. 31 CFR 552.202 - Effect of transfers violating the provisions of this part.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false Effect of transfers violating the provisions of this part. 552.202 Section 552.202 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY YEMEN...

  19. 31 CFR 552.202 - Effect of transfers violating the provisions of this part.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false Effect of transfers violating the provisions of this part. 552.202 Section 552.202 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY YEMEN...

  20. 31 CFR 540.202 - Effect of transfers violating the provisions of this part.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... URANIUM (HEU) AGREEMENT ASSETS CONTROL REGULATIONS Prohibitions § 540.202 Effect of transfers violating... with the Office of Foreign Assets Control a report setting forth in full the circumstances relating to... fraudulently obtained. Note to paragraph (d) of § 540.202: The filing of a report in accordance with...

  1. 31 CFR 540.202 - Effect of transfers violating the provisions of this part.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false Effect of transfers violating the provisions of this part. 540.202 Section 540.202 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY HIGHLY ENRICHED URANIUM (HEU) AGREEMENT ASSETS...

  2. 31 CFR 540.202 - Effect of transfers violating the provisions of this part.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... URANIUM (HEU) AGREEMENT ASSETS CONTROL REGULATIONS Prohibitions § 540.202 Effect of transfers violating... with the Office of Foreign Assets Control a report setting forth in full the circumstances relating to... fraudulently obtained. Note to paragraph (d) of § 540.202: The filing of a report in accordance with...

  3. 31 CFR 540.202 - Effect of transfers violating the provisions of this part.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... URANIUM (HEU) AGREEMENT ASSETS CONTROL REGULATIONS Prohibitions § 540.202 Effect of transfers violating... with the Office of Foreign Assets Control a report setting forth in full the circumstances relating to... fraudulently obtained. Note to paragraph (d) of § 540.202: The filing of a report in accordance with...

  4. 31 CFR 540.202 - Effect of transfers violating the provisions of this part.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... URANIUM (HEU) AGREEMENT ASSETS CONTROL REGULATIONS Prohibitions § 540.202 Effect of transfers violating... with the Office of Foreign Assets Control a report setting forth in full the circumstances relating to... fraudulently obtained. Note to paragraph (d) of § 540.202: The filing of a report in accordance with...

  5. 31 CFR 537.207 - Effect of transfers violating the provisions of this part.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false Effect of transfers violating the provisions of this part. 537.207 Section 537.207 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY BURMESE...

  6. 31 CFR 515.203 - Effect of transfers violating the provisions of this part.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 31 Money and Finance:Treasury 3 2012-07-01 2012-07-01 false Effect of transfers violating the provisions of this part. 515.203 Section 515.203 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY CUBAN...

  7. 31 CFR 500.203 - Effect of transfers violating the provisions of this chapter.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Effect of transfers violating the provisions of this chapter. 500.203 Section 500.203 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY FOREIGN...

  8. 31 CFR 515.203 - Effect of transfers violating the provisions of this part.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false Effect of transfers violating the provisions of this part. 515.203 Section 515.203 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY CUBAN...

  9. 31 CFR 515.203 - Effect of transfers violating the provisions of this part.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Effect of transfers violating the provisions of this part. 515.203 Section 515.203 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY CUBAN...

  10. 31 CFR 515.203 - Effect of transfers violating the provisions of this part.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false Effect of transfers violating the provisions of this part. 515.203 Section 515.203 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY CUBAN...

  11. 31 CFR 515.203 - Effect of transfers violating the provisions of this part.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false Effect of transfers violating the provisions of this part. 515.203 Section 515.203 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY CUBAN...

  12. 31 CFR 594.202 - Effect of transfers violating the provisions of this part.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Effect of transfers violating the provisions of this part. 594.202 Section 594.202 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY GLOBAL...

  13. 31 CFR 541.202 - Effect of transfers violating the provisions of this part.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Effect of transfers violating the provisions of this part. 541.202 Section 541.202 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY...

  14. 31 CFR 562.202 - Effect of transfers violating the provisions of this part.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false Effect of transfers violating the provisions of this part. 562.202 Section 562.202 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY IRANIAN HUMAN RIGHTS ABUSES SANCTIONS REGULATIONS...

  15. 31 CFR 562.202 - Effect of transfers violating the provisions of this part.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 31 Money and Finance:Treasury 3 2012-07-01 2012-07-01 false Effect of transfers violating the provisions of this part. 562.202 Section 562.202 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY IRANIAN HUMAN RIGHTS ABUSES SANCTIONS REGULATIONS...

  16. 31 CFR 562.202 - Effect of transfers violating the provisions of this part.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY IRANIAN HUMAN RIGHTS ABUSES SANCTIONS REGULATIONS Prohibitions § 562.202 Effect of transfers violating the provisions... void and shall not be the basis for the assertion or recognition of any interest in or right,...

  17. 31 CFR 562.202 - Effect of transfers violating the provisions of this part.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY IRANIAN HUMAN RIGHTS ABUSES SANCTIONS REGULATIONS Prohibitions § 562.202 Effect of transfers violating the provisions... void and shall not be the basis for the assertion or recognition of any interest in or right,...

  18. 31 CFR 548.202 - Effect of transfers violating the provisions of this part.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Effect of transfers violating the provisions of this part. 548.202 Section 548.202 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY BELARUS...

  19. 31 CFR 588.202 - Effect of transfers violating the provisions of this part.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... provisions of this part. 588.202 Section 588.202 Money and Finance: Treasury Regulations Relating to Money... STABILIZATION REGULATIONS Prohibitions § 588.202 Effect of transfers violating the provisions of this part. (a... any property or interest in property blocked pursuant to § 588.201(a), is null and void and shall...

  20. 31 CFR 549.202 - Effect of transfers violating the provisions of this part.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false Effect of transfers violating the provisions of this part. 549.202 Section 549.202 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY LEBANON...

  1. 31 CFR 549.202 - Effect of transfers violating the provisions of this part.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false Effect of transfers violating the provisions of this part. 549.202 Section 549.202 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY LEBANON...

  2. 31 CFR 549.202 - Effect of transfers violating the provisions of this part.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 31 Money and Finance:Treasury 3 2012-07-01 2012-07-01 false Effect of transfers violating the provisions of this part. 549.202 Section 549.202 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY LEBANON...

  3. 31 CFR 549.202 - Effect of transfers violating the provisions of this part.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false Effect of transfers violating the provisions of this part. 549.202 Section 549.202 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY LEBANON...

  4. 31 CFR 538.202 - Effect of transfers violating the provisions of this part.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false Effect of transfers violating the provisions of this part. 538.202 Section 538.202 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY...

  5. 31 CFR 537.207 - Effect of transfers violating the provisions of this part.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Effect of transfers violating the provisions of this part. 537.207 Section 537.207 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY BURMESE...

  6. 31 CFR 510.202 - Effect of transfers violating the provisions of this part.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false Effect of transfers violating the provisions of this part. 510.202 Section 510.202 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY NORTH...

  7. 31 CFR 541.202 - Effect of transfers violating the provisions of this part.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false Effect of transfers violating the provisions of this part. 541.202 Section 541.202 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY...

  8. 31 CFR 541.202 - Effect of transfers violating the provisions of this part.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false Effect of transfers violating the provisions of this part. 541.202 Section 541.202 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY...

  9. 31 CFR 541.202 - Effect of transfers violating the provisions of this part.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false Effect of transfers violating the provisions of this part. 541.202 Section 541.202 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY...

  10. 31 CFR 541.202 - Effect of transfers violating the provisions of this part.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 31 Money and Finance:Treasury 3 2012-07-01 2012-07-01 false Effect of transfers violating the provisions of this part. 541.202 Section 541.202 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY...

  11. Abstinence-Only Debate Heating Up

    ERIC Educational Resources Information Center

    Bowman, Darcia Harris

    2004-01-01

    President Bush's proposal to almost double the amount of money the federal government spends on abstinence education to $273 million in fiscal 2005 has raised the stakes in the battle over what to teach children and adolescents about sex. Only a small percentage of Americans believe abstinence-only programs are the best form of sex education for…

  12. Smokers’ Expectancies for Abstinence: Preliminary Results from Focus Groups

    PubMed Central

    Hendricks, Peter S.; Wood, Sabrina B.; Hall, Sharon M.

    2010-01-01

    Smokers’ expectancies regarding the effects of cigarette use are powerful predictors of smoking motivation and behavior. However, studies have not investigated the consequences that smokers expect when they attempt to quit smoking: abstinence-related expectancies. The primary goal of this qualitative study was to gain initial insight into smokers’ expectancies for abstinence. Eight focus groups were conducted with 30 smokers diverse with respect to age, gender, and ethnoracial background. Content analyses indicated that smokers anticipate a variety of outcomes from abstinence. The most frequently reported expectancies included pharmacologic withdrawal symptoms, behavioral withdrawal symptoms, decreased monetary expense, and immediate improvement of certain aspects of physical functioning and health. Additional expectancies concerned weight gain, improved attractiveness, enhanced social functioning/self-esteem, long-term health outcomes, and loss of relationships. Finally, a number of relatively unheralded expectancies were revealed. These involved NRT effectiveness, alcohol and other drug use, vigilance to cue reactivity, cessation-related social support, aversion to smoking, and “political process” implications. This study provides a preliminary step in understanding smokers’ expectancies for abstinence from cigarettes. PMID:19586157

  13. Effects of disputes and easement violations on the cost-effectiveness of land conservation

    PubMed Central

    Arcese, Peter

    2015-01-01

    Conservation initiatives to protect and restore valued species communities in human-dominated landscapes face challenges linked to their potential costs. Conservation easements on private land may represent a cost-effective alternative to land purchase, but long-term costs to monitor and enforce easements, or defend legal challenges, remain uncertain. We explored the cost-effectiveness of conservation easements, defined here as the fraction of the high-biodiversity landscape potentially protected via investment in easements versus land purchase. We show that easement violation and dispute rates substantially affect the estimated long-term cost-effectiveness of an easement versus land purchase strategy. Our results suggest that conservation easements can outperform land purchase as a strategy to protect biodiversity as long as the rate of disputes and legal challenges is low, pointing to a critical need for monitoring data to reduce costs and maximize the value of conservation investments. PMID:26413430

  14. Systematic Review of Abstinence-Plus HIV Prevention Programs in High-Income Countries

    PubMed Central

    Underhill, Kristen; Operario, Don; Montgomery, Paul

    2007-01-01

    Background Abstinence-plus (comprehensive) interventions promote sexual abstinence as the best means of preventing HIV, but also encourage condom use and other safer-sex practices. Some critics of abstinence-plus programs have suggested that promoting safer sex along with abstinence may undermine abstinence messages or confuse program participants; conversely, others have suggested that promoting abstinence might undermine safer-sex messages. We conducted a systematic review to investigate the effectiveness of abstinence-plus interventions for HIV prevention among any participants in high-income countries as defined by the World Bank. Methods and Findings Cochrane Collaboration systematic review methods were used. We included randomized and quasi-randomized controlled trials of abstinence-plus programs for HIV prevention among any participants in any high-income country; trials were included if they reported behavioural or biological outcomes. We searched 30 electronic databases without linguistic or geographical restrictions to February 2007, in addition to contacting experts, hand-searching conference abstracts, and cross-referencing papers. After screening 20,070 abstracts and 325 full published and unpublished papers, we included 39 trials that included approximately 37,724 North American youth. Programs were based in schools (10), community facilities (24), both schools and community facilities (2), health care facilities (2), and family homes (1). Control groups varied. All outcomes were self-reported. Quantitative synthesis was not possible because of heterogeneity across trials in programs and evaluation designs. Results suggested that many abstinence-plus programs can reduce HIV risk as indicated by self-reported sexual behaviours. Of 39 trials, 23 found a protective program effect on at least one sexual behaviour, including abstinence, condom use, and unprotected sex (baseline n = 19,819). No trial found adverse program effects on any behavioural outcome

  15. Why emotions matter: expectancy violation and affective response mediate the emotional victim effect.

    PubMed

    Ask, Karl; Landström, Sara

    2010-10-01

    The mechanisms behind the 'emotional victim effect' (i.e., that the emotionality of a rape victim's demeanor affects perceived credibility) are relatively unexplored. In this article, a previously neglected mechanism--observers' affective response to the victim--is proposed as an alternative to the traditional expectancy-violation account. The emotional victim effect was replicated in an experiment with a sample of police trainees (N = 189), and cognitive load was found to increase the magnitude of the effect. Importantly, both compassionate affective response and expectancy violation actively mediated the emotional victim effect when the other mechanism was controlled for. These findings extend previous research on credibility judgments by introducing a 'hot' cognitive component in the judgment process. Theoretical and practical implications are discussed. PMID:20107882

  16. Predictors of Abstinence Self-Efficacy: Examining the role of HIV-risk Sexual Behavior

    PubMed Central

    Majer, John M.; Glantsman, Olya; Palmer, John S.; Jason, Leonard A.

    2016-01-01

    Abstinence self-efficacy, or the confidence in ones’ beliefs in one’s ability to effectively engage in behaviors to maintain substance use abstinence, is a crucial recovery resource. However, little research has been conducted on what predicts increases in this recovery resource. Understanding predictors of abstinence self-efficacy could help social service practitioners in creating effective treatment plans/interventions while extending what is presently known in this small body of research. Predictors of abstinence self-efficacy were analyzed among a sample of ex-offenders (224 men and 46 women) who were completing inpatient treatment for substance use disorders. Hierarchical linear regression was conducted to examine changes in participants’ abstinence self-efficacy in relation to factors directly related (HIV-risk drug use behaviors, substance use, 12-step meeting attendance) and indirectly related (HIV-risk sexual behaviors, incarceration histories) to substance use. HIV-risk sexual behaviors and substance use predicted significant decreases in abstinence self-efficacy whereas 12-step meeting attendance predicted significant increases. However, incarceration histories and HIV-risk drug use behaviors were not significant predictors of abstinence self-efficacy. Findings suggest HIV-risk sexual behavior should be considered when assessing relapse prevention for persons with substance use disorders, and that researchers should examine behaviors that are not directly related to substance use when investigating recovery resources.

  17. Repeated episodes of heroin cause enduring alterations of circadian activity in protracted abstinence.

    PubMed

    Stinus, Luis; Cador, Martine; Caille, Stephanie

    2012-01-01

    Opiate withdrawal is followed by a protracted abstinence syndrome consisting of craving and physiological changes. However, few studies have been dedicated to both the characterization and understanding of these long-term alterations in post-dependent subjects. The aim of the present study was to develop an opiate dependence model, which induces long-lasting behavioral changes in abstinent rats. Here, we first compared the effects of several protocols for the induction of opiate dependence (morphine pellets, repeated morphine or heroin injections) on the subsequent response to heroin challenges (0.25 mg/kg) at different time points during abstinence (3, 6, 9 and 18 weeks). In a second set of experiments, rats were exposed to increasing doses of heroin and subsequently monitored for general circadian activity up to 20 weeks of abstinence. Results show that heroin injections rather than the other methods of opiate administration have long-term consequences on rats' sensitivity to heroin with its psychostimulant effects persisting up to 18 weeks of abstinence. Moreover, intermittent episodes of heroin dependence rather than a single exposure produce enduring alteration of the basal circadian activity both upon heroin cessation and protracted abstinence. Altogether, these findings suggest that the induction of heroin dependence through intermittent increasing heroin injections is the optimal method to model long-term behavioral alterations during protracted abstinence in rats. This animal model would be useful in further characterizing long-lasting changes in post-dependent subjects to help understand the prolonged vulnerability to relapse. PMID:24961201

  18. Repeated Episodes of Heroin Cause Enduring Alterations of Circadian Activity in Protracted Abstinence

    PubMed Central

    Stinus, Luis; Cador, Martine; Caille, Stephanie

    2012-01-01

    Opiate withdrawal is followed by a protracted abstinence syndrome consisting of craving and physiological changes. However, few studies have been dedicated to both the characterization and understanding of these long-term alterations in post-dependent subjects. The aim of the present study was to develop an opiate dependence model, which induces long-lasting behavioral changes in abstinent rats. Here, we first compared the effects of several protocols for the induction of opiate dependence (morphine pellets, repeated morphine or heroin injections) on the subsequent response to heroin challenges (0.25 mg/kg) at different time points during abstinence (3, 6, 9 and 18 weeks). In a second set of experiments, rats were exposed to increasing doses of heroin and subsequently monitored for general circadian activity up to 20 weeks of abstinence. Results show that heroin injections rather than the other methods of opiate administration have long-term consequences on rats’ sensitivity to heroin with its psychostimulant effects persisting up to 18 weeks of abstinence. Moreover, intermittent episodes of heroin dependence rather than a single exposure produce enduring alteration of the basal circadian activity both upon heroin cessation and protracted abstinence. Altogether, these findings suggest that the induction of heroin dependence through intermittent increasing heroin injections is the optimal method to model long-term behavioral alterations during protracted abstinence in rats. This animal model would be useful in further characterizing long-lasting changes in post-dependent subjects to help understand the prolonged vulnerability to relapse. PMID:24961201

  19. Plasma lipoprotein changes during abstinence in chronic alcoholics.

    PubMed

    Weidman, S W; Beard, J D; Sabesin, S M

    1984-08-01

    Plasma lipoprotein changes during a 2-week period of abstinence were followed in 6 male, chronic alcoholics without evidence of severe liver disease and with initial HDL cholesterol (HDL-CH) greater than 60 mg/dl. Fasting blood samples were obtained on days 1, 3, 7 and 14 of the study. Reference data were obtained from healthy non-alcoholic normolipidemic men who had abstained from alcohol for 10 days. At day 1, plasma- and HDL-CH (by the heparin-Mn2+ technique) were 17 and 69% higher, respectively, than those of controls. During abstinence, VLDL-CH increased 52% whereas HDL-CH decreased 30% compared to day 1 values. (IDL + LDL)-CH increased during abstinence to levels 33% higher than that of controls. Plasma, SF greater than 400, VLDL- and d greater than 1.006 g/ml-triglycerides (TG) were not significantly different from those of the control group. Only the d greater than 1.006 g/ml-TG showed a significant effect of abstinence, increasing by 37%. Initial plasma and d greater than 1.006 g/ml-phospholipid (PL) concentrations were 17 and 31% higher, respectively, than those of controls; and the latter was the only fraction to change significantly with abstinence, decreasing by 13%. Density gradient ultracentrifugation was employed to further resolve the d greater than 1.006 g/ml fraction into IDL, LDL, HDL and VHDL subfractions. Initial levels of IDL- and LDL-CH and -PL in the alcoholic group did not differ from those of controls. IDL-CH and -PL were invariant during abstinence, whereas LDL-CH and -PL levels increased 38 and 28%, during this period. Apo A-I, CH and PL contained in the 'lighter' density HDL region of the gradient (d = 1.063-1.125 g/ml) were 70-108% increased over the corresponding parameters for controls; and with abstinence decreased 30-40% between days 1 and 14. CH and PL in the 'heavier' density HDL region (d = 1.125-1.21 g/ml) were 30% increased over those of controls, while apo A-I levels were similar to controls. During abstinence, 'heavy' HDL

  20. The application of Bandura's self-efficacy theory to abstinence-oriented alcoholism treatment.

    PubMed

    Rollnick, S; Heather, N

    1982-01-01

    This paper explores the relevance of self-efficacy theory (Bandura, 1977b) to the process of abstinence treatment and the phenomenon of relapse. By distinguishing between the particular efficacy and outcome expectations created in treatment it is possible to clarify some of the problems encountered between clinicians and alcoholics. Bandura's theory also explains why some treatment methods might be more effective than others. Analysis of relapse suggests that while some of the expectations created in treatment might serve to promote abstinence, others might unwittingly precipitate relapse. The understanding of abstinence treatment could be enhanced by the testing of hypotheses which emerge from this analysis. PMID:7180618

  1. Enhancing the Effect of Lorentz Invariance and Einstein's Equivalence Principle Violation in Nuclei and Atoms

    NASA Astrophysics Data System (ADS)

    Flambaum, V. V.

    2016-08-01

    Local Lorentz invariance violating (LLIV) and Einstein equivalence principle violating (EEPV) effects in atomic experiments are discussed. The EEPV effects are strongly enhanced in the narrow 7.8 eV transition in the Th22990 nucleus. The nuclear LLIV tensors describing the anisotropy in the maximal attainable speed for massive particles (analog of the Michelson-Morley experiment for light) are expressed in terms of the experimental values of the nuclear quadrupole moments. Calculations for nuclei of experimental interest Cs13355 , Rb8537 , Rb8737 , Hg20180 , Xe13154 , and Ne2110 are performed. The results for Ne2110 are used to improve the limits on the proton LLIV interaction constants by 4 orders of magnitude.

  2. Enhancing the Effect of Lorentz Invariance and Einstein's Equivalence Principle Violation in Nuclei and Atoms.

    PubMed

    Flambaum, V V

    2016-08-12

    Local Lorentz invariance violating (LLIV) and Einstein equivalence principle violating (EEPV) effects in atomic experiments are discussed. The EEPV effects are strongly enhanced in the narrow 7.8 eV transition in the _{90}^{229}Th nucleus. The nuclear LLIV tensors describing the anisotropy in the maximal attainable speed for massive particles (analog of the Michelson-Morley experiment for light) are expressed in terms of the experimental values of the nuclear quadrupole moments. Calculations for nuclei of experimental interest _{55}^{133}Cs, _{37}^{85}Rb, _{37}^{87}Rb, _{80}^{201}Hg, _{54}^{131}Xe, and _{10}^{21}Ne are performed. The results for _{10}^{21}Ne are used to improve the limits on the proton LLIV interaction constants by 4 orders of magnitude. PMID:27563955

  3. Understanding Sexual Abstinence in Urban Adolescent Girls

    PubMed Central

    Morrison-Beedy, Dianne; Carey, Michael P.; Côté-Arsenault, Denise; Seibold-Simpson, Susan; Robinson, Kerry Anne

    2008-01-01

    Objectives To gain insight into the context of sexual abstinence and identify potential determinants of abstinence in this population. Design Four focus groups. Participants and Setting Twenty-four, predominantly African American (88%) girls aged 14 to 19 years were recruited from urban health centers and youth development programs in Rochester, New York, between September and December 2006. Data Analysis Content analysis was used to analyze the four verbatim transcripts. Using analytic induction, groups were compared and contrasted at the micro (within-group) and macro (between-group) levels to identify themes. Results Four themes were identified that provided insight into how and why these girls remain abstinent despite being in sexually active social climates. They focused on the following: self-respect (I'm worth it), impact of mothers (Mama says … think before you let it go), influence of boys and other peers (Boys will be boys), and potential negative consequences of sex (Hold on, there's a catch). Conclusions Developing interventions to maintain abstinence, delay onset of sexual activity, and promote protected first and subsequent sexual contact in abstinent girls are key to decreasing future sexual risk. These findings suggest opportunities to develop HIV prevention strategies tailored to the needs of abstinent girls. PMID:18336442

  4. Beyond Abstinence-Only: Relationships between Abstinence Education and Comprehensive Topic Instruction

    ERIC Educational Resources Information Center

    Jeffries, William L., IV; Dodge, Brian; Bandiera, Frank C.; Reece, Michael

    2010-01-01

    In the United States, a debate exists as to whether abstinence-only or comprehensive sexuality education strategies are most beneficial for school-age youth. Despite abstinence being a fundamental component of comprehensive education, the two are often characterized as polar opposites. Few studies have examined overlaps between the approaches. The…

  5. Abstinence-Related Word Associations and Definitions of Abstinence and Virginity among Missouri High School Freshmen

    ERIC Educational Resources Information Center

    Wilson, Kelly L.; Smith, Matthew Lee; Menn, Mindy

    2013-01-01

    Background: The ways in which adolescents define and view sex, abstinence, and virginity impact the efforts of sexuality educators and sexual health professionals. This study examined terminology used by nonsexually active high school students to define abstinence and virginity and identified words students associate with these terms. Purposes…

  6. Abstinence Self-Efficacy and Abstinence 1 Year After Substance Use Disorder Treatment

    ERIC Educational Resources Information Center

    Ilgen, Mark; McKellar, John; Tiet, Quyen

    2005-01-01

    To better understand the relationship between abstinence self-efficacy and treatment outcomes in substance use disorder patients, experts in the field need more information about the levels of abstinence self-efficacy most predictive of treatment outcomes. Participants (N = 2,967) from 15 residential substance use disorder treatment programs were…

  7. Non-Standard v-Interactions at a Neutrino Factory: Correlation and CP violation effects

    SciTech Connect

    Lopez-Pavon, Jacobo

    2011-10-06

    The so-called Non-Standard v-Interactions in propagation is a widely studied topic in the Neutrino Factory literature. However, special attention has not been paid to the possible correlation effects among the whole set of parameters arising in this context (standard and non-standard ones). Here we will focus on these correlation effects analysing the performance of three different Neutrino Factory setups. In addition, we explore the new avenues of CP violation coming from this sort of Non-Standard v-Interactions with the same perspective, in other words, studying the relation among the several CP-phases involved.

  8. Insensitivity of Leptogenesis with Flavor Effects to Low Energy Leptonic CP Violation

    NASA Astrophysics Data System (ADS)

    Davidson, Sacha; Garayoa, Julia; Palorini, Federica; Rius, Nuria

    2007-10-01

    If the baryon asymmetry of the Universe is produced by leptogenesis, CP violation is required in the lepton sector. In the seesaw extension of the standard model with three hierarchical right-handed neutrinos, we show that the baryon asymmetry is insensitive to the Pontecorvo-Maki-Nagakawa-Sakata phases: thermal leptogenesis can work for any value of the observable phases. This result was well known when there were no flavor effects in leptogenesis; we show that it remains true when flavor effects are included.

  9. Insensitivity of Leptogenesis with Flavor Effects to Low Energy Leptonic CP Violation

    SciTech Connect

    Davidson, Sacha; Palorini, Federica; Garayoa, Julia; Rius, Nuria

    2007-10-19

    If the baryon asymmetry of the Universe is produced by leptogenesis, CP violation is required in the lepton sector. In the seesaw extension of the standard model with three hierarchical right-handed neutrinos, we show that the baryon asymmetry is insensitive to the Pontecorvo-Maki-Nagakawa-Sakata phases: thermal leptogenesis can work for any value of the observable phases. This result was well known when there were no flavor effects in leptogenesis; we show that it remains true when flavor effects are included.

  10. “That's Nasty” to Curiosity: Early Adolescent Cognitions about Sexual Abstinence

    PubMed Central

    Ott, Mary A.; Pfeiffer, Elizabeth J.

    2010-01-01

    Purpose Effective sex education for early adolescents should make use of age-appropriate cultural models about sexual abstinence. However, little is known about how early adolescents view this topic. We describe developmental differences in cognitions about sexual abstinence among high risk early adolescents. Methods After IRB approval and informed consent, we interviewed twenty-two 11-14 year-olds, using a qualitative, two-stage interview. Participants were first asked a series of open-ended questions about sexual abstinence, and then asked to explain their answers. Interviews were transcribed, organized by age, and read in their entirety. Codes were developed from the literature, field notes, and transcripts. Key concepts were identified and models were developed with a focus on developmental change. Results We observed three distinct views of sexual abstinence, “That's Nasty,” “Curious,” and Normative. All viewed abstinence as a starting point and sex as a transition to adulthood. “That's Nasty” participants identified sex as distasteful, displayed limited understanding of sex, and viewed abstinence as appropriate for kids like themselves. Curious participants expressed a desire for information about sex, and a sense of missing something important. Normative participants viewed the transition from abstinence to sexual experience as part of a normal, albeit challenging, transition to adulthood. Conclusions Participants demonstrated differences in cognitions about sexual abstinence, related to age and development. The transition from viewing sex as distasteful to curiosity appears to be a time of both vulnerability and openness, and may provide an opportunity for intervention. PMID:19465322

  11. Abstinence from chronic cocaine self-administration alters striatal dopamine systems in rhesus monkeys.

    PubMed

    Beveridge, Thomas J R; Smith, Hilary R; Nader, Michael A; Porrino, Linda J

    2009-04-01

    Although dysregulation within the dopamine (DA) system is a hallmark feature of chronic cocaine exposure, the question of whether these alterations persist into abstinence remains largely unanswered. Nonhuman primates represent an ideal model in which to assess the effects of abstinence on the DA system following chronic cocaine exposure. In this study, male rhesus monkeys self-administered cocaine (0.3 mg/kg per injection, 30 reinforcers per session) under a fixed-interval 3-min schedule for 100 days followed by either 30 or 90 days abstinence. This duration of cocaine self-administration has been previously shown to decrease DA D2-like receptor densities and increase levels of D1-like receptors and DA transporters (DAT). Responding by control monkeys was maintained by food presentation under an identical protocol and the same abstinence periods. [(3)H]SCH 23390 binding to DA D1 receptors following 30 days of abstinence was significantly higher in all portions of the striatum, compared to control animals, whereas [(3)H]raclopride binding to DA D2 receptors was not different between groups. [(3)H]WIN 35 428 binding to DAT was also significantly higher throughout virtually all portions of the dorsal and ventral striatum following 30 days of abstinence. Following 90 days of abstinence, however, levels of DA D1 receptors and DAT were not different from control values. Although these results indicate that there is eventual recovery of the separate elements of the DA system, they also highlight the dynamic nature of these components during the initial phases of abstinence from chronic cocaine self-administration. PMID:18769473

  12. Abstinence from Chronic Cocaine Self-Administration Alters Striatal Dopamine Systems in Rhesus Monkeys

    PubMed Central

    Beveridge, Thomas JR; Smith, Hilary R; Nader, Michael A; Porrino, Linda J

    2013-01-01

    Although dysregulation within the dopamine (DA) system is a hallmark feature of chronic cocaine exposure, the question of whether these alterations persist into abstinence remains largely unanswered. Nonhuman primates represent an ideal model in which to assess the effects of abstinence on the DA system following chronic cocaine exposure. In this study, male rhesus monkeys self-administered cocaine (0.3 mg/kg per injection, 30 reinforcers per session) under a fixed-interval 3-min schedule for 100 days followed by either 30 or 90 days abstinence. This duration of cocaine self-administration has been previously shown to decrease DA D2-like receptor densities and increase levels of D1-like receptors and DA transporters (DAT). Responding by control monkeys was maintained by food presentation under an identical protocol and the same abstinence periods. [3H]SCH 23390 binding to DA D1 receptors following 30 days of abstinence was significantly higher in all portions of the striatum, compared to control animals, whereas [3H]raclopride binding to DA D2 receptors was not different between groups. [3H]WIN 35 428 binding to DAT was also significantly higher throughout virtually all portions of the dorsal and ventral striatum following 30 days of abstinence. Following 90 days of abstinence, however, levels of DA D1 receptors and DAT were not different from control values. Although these results indicate that there is eventual recovery of the separate elements of the DA system, they also highlight the dynamic nature of these components during the initial phases of abstinence from chronic cocaine self-administration. PMID:18769473

  13. Study of the CP-violating effects with gg → Η → τ+τ- process

    NASA Astrophysics Data System (ADS)

    Belyaev, N. L.; Konoplich, R. V.

    2015-12-01

    Study of the gg → Η → τ+τ- process was performed at Monte Carlo level within the framework of searching for CP-violating effects. The sensitivity of chosen observables to CP-parity of the Higgs boson was demonstrated for hadronic 1-prong τ decays (τ± → π±, ρ±). Monte Carlo samples for the gg → Η → τ+τ- process were generated including the parton hadronisation to final state particles. This generation was performed for the Standard Model Higgs boson, the pseudoscalar Higgs boson, the Z → τ+τ- background, and mixed CP-states of the Higgs boson.

  14. Effective Field Theory and Time-Reversal Violation in Light Nuclei

    NASA Astrophysics Data System (ADS)

    Mereghetti, E.; van Kolck, U.

    2015-10-01

    Thanks to the unnaturally small value of the QCD vacuum angle [Formula: see text], time-reversal violation ([Formula: see text]) offers a window into physics beyond the Standard Model (SM) of particle physics. We review the effective field theory framework that establishes a clean connection between (a) [Formula: see text] mechanisms, which can be represented by higher-dimensional operators involving SM fields and symmetries, and (b) hadronic interactions, which allow for controlled calculations of low-energy observables involving strong interactions. The chiral properties of [Formula: see text] mechanisms lead to a pattern that should be identifiable in measurements of the electric dipole moments of the nucleon and light nuclei.

  15. Effects of extrinsic curvature as modified Chaplygin gas and Lorentz violation

    NASA Astrophysics Data System (ADS)

    Ahmadi, F.

    2016-05-01

    The modified Chaplygin gas may be considered as a popular candidate for dark energy. We apply a gravitational explanation for the modified Chaplygin gas within the context of brane-world theory without using any junction condition or Z2 symmetry. Then, we study the behavior of the deceleration parameter and age of the universe in this framework. Also, we investigate the effect of the modified Chaplygin gas on the speed of the propagation of gravitational waves and explore local Lorentz violation in this model.

  16. Subjective Social Status Affects Smoking Abstinence During Acute Withdrawal Through Affective Mediators

    PubMed Central

    Reitzel, Lorraine R.; Mazas, Carlos A.; Cofta-Woerpel, Ludmila; Li, Yisheng; Cao, Yumei; Businelle, Michael S.; Cinciripini, Paul M.; Wetter, David W.

    2010-01-01

    Objectives Direct and mediated associations between subjective social status (SSS), a subjective measure of socioeconomic status, and smoking abstinence were examined during the period of acute withdrawal among a diverse sample of 421 smokers (33% Caucasian, 34% African-American, 33% Latino) undergoing a quit attempt. Methods Logistic regressions examined relations between SSS and abstinence, controlling for sociodemographic variables. Depression, stress, positive affect, and negative affect on the quit day were examined as potential affective mediators of the SSS-abstinence association, with and without adjusting for pre-quit mediator scores. Results SSS predicted abstinence through 2 weeks post-quit. Abstinence rates were approximately 2.5 times higher in the highest versus the lowest SSS quartile. Depression and positive affect mediated the SSS-abstinence relationships, but only depression maintained significance when adjusting for the baseline mediator score. Conclusions Among a diverse sample of quitting smokers, low SSS predicted relapse during acute withdrawal after controlling for numerous covariates, an effect partially accounted for by quit day affective symptomatology. Smokers endorsing lower SSS face significant hurdles in achieving cessation, highlighting the need for targeted interventions encompassing attention to quit day mood reactivity. PMID:20219054

  17. Analysing the Effect on CMB in a Parity and Charge Parity Violating Varying Alpha Theory

    SciTech Connect

    Maity, Debaprasad; Chen, Pisin; /NCTS, Taipei /Taiwan, Natl. Taiwan U. /KIPAC, Menlo Park /SLAC

    2012-09-14

    In this paper we study in detail the effect of our recently proposed model of parity and charge-parity (PCP) violating varying alpha on the Cosmic Microwave Background (CMB) photon passing through the intra galaxy-cluster medium (ICM). The ICM is well known to be composed of magnetized plasma. According to our model, the polarization and intensity of the CMB would be affected when traversing through the ICM due to non-trivial scalar photon interactions. We have calculated the evolution of such polarization and intensity collectively, known as the stokes parameters of the CMB photon during its journey through the ICM and tested our results against the Sunyaev-Zel'dovich (SZ) measurement on Coma galaxy cluster. Our model contains a PCP violating parameter, {beta}, and a scale of alpha variation {omega}. Using the derived constrained on the photon-to-scalar conversion probability, {bar P}{sub {gamma}{yields}{phi}}, for Coma cluster in ref.[34] we found a contour plot in the ({omega},{beta}) parameter plane. The {beta} = 0 line in this parameter space corresponds to well-studied Maxwell-dilaton type models which has lower bound on {omega} {approx}> 6.4 x 10{sup 9} GeV. In general, as the absolute value of {beta} increases, lower bound on {omega} also increases. Our model in general predicts the modification of the CMB polarization with a non-trivial dependence on the parity violating coupling parameter {beta}. However, it is unconstrained in this particular study. We show that this effect can in principle be detected in the future measurements on CMB polarization such that {beta} can also be constrained.

  18. Correlations among new CP violating effects in {delta}F=2 observables

    SciTech Connect

    Buras, Andrzej J.; Guadagnoli, Diego

    2008-08-01

    We point out that the observed CP violation in B{sub d}-B{sub d} mixing, taking into account the measured ratio {delta}M{sub d}/{delta}M{sub s}, the recently decreased lattice value of the nonperturbative parameter B-circumflex{sub K} and an additional effective suppression factor {kappa}{sub {epsilon}}{approx_equal}0.92 in {epsilon}{sub K} neglected so far in most analyses, may be insufficient to describe the measured value of {epsilon}{sub K} within the standard model (SM), thus hinting at new CP violating contributions to the K-K and/or B{sub d}-B{sub d} systems. Furthermore, assuming that {delta}M{sub d}/{delta}M{sub s} is SM-like, the signs and the magnitudes of new-physics effects in {epsilon}{sub K} and in the CP asymmetries S{sub {psi}}{sub K{sub s}} and S{sub {psi}}{sub {phi}} may turn out to be correlated. For example, in a scenario with new CP phases in B{sub d} and B{sub s} mixings being approximately equal and negative, a common new phase {approx_equal}-5 deg. could remove the tension between {epsilon}{sub K} and S{sub {psi}}{sub K{sub s}} present in the SM and simultaneously accommodate, at least partly, the recent claim of S{sub {psi}}{sub {phi}} being much larger than the SM expectation. We emphasize the importance of precise determinations of V{sub cb}, B-circumflex{sub K}, F{sub K}, and {xi}{sub s}, to which the parameter {epsilon}{sub K} and its correlation with the CP violation in the B{sub d}-B{sub d} system are very sensitive.

  19. The effective chiral Lagrangian from dimension-six parity and time-reversal violation

    SciTech Connect

    Vries, J. de; Mereghetti, E.; Timmermans, R.G.E.; Kolck, U. van

    2013-11-15

    We classify the parity- and time-reversal-violating operators involving quark and gluon fields that have effective dimension six: the quark electric dipole moment, the quark and gluon chromo-electric dipole moments, and four four-quark operators. We construct the effective chiral Lagrangian with hadronic and electromagnetic interactions that originate from them, which serves as the basis for calculations of low-energy observables. The form of the effective interactions depends on the chiral properties of these operators. We develop a power-counting scheme and calculate within this scheme, as an example, the parity- and time-reversal-violating pion–nucleon form factor. We also discuss the electric dipole moments of the nucleon and light nuclei. -- Highlights: •Classification of T-odd dimension-six sources based on impact on observables. •Building of the chiral Lagrangian for each dimension-six source. •Calculation of the PT-odd pion–nucleon form factor for each source. •Discussion of hadronic EDMs for each source and comparison with the theta term.

  20. Effects of red light cameras on violations and crashes: a review of the international literature.

    PubMed

    Retting, Richard A; Ferguson, Susan A; Hakkert, A Shalom

    2003-03-01

    Red light running is a frequent cause of motor vehicle crashes and injuries. A primary countermeasure for red light running crashes is police traffic enforcement. In recent years, many police agencies have begun using automated red light cameras as a supplement to conventional enforcement methods. The present study reviewed and evaluated available evidence in the international literature regarding the effectiveness of cameras to reduce both red light violations and crashes. Camera enforcement generally reduces violations by an estimated 40-50%. In terms of crash effects, most studies contain methodological flaws that, to varying degrees, either overestimate (failure to adjust for regression to the mean) or underestimate (comparison with nearby signalized intersections affected by cameras) crash effects. Mindful of these limitations, the research generally indicates that camera enforcement can significantly reduce injury crashes at signalized intersections, in particular right-angle injury crashes. Most studies reported increases in rear-end crashes following camera installation. Taken together the studies indicate that, overall, injury crashes, including rear-end collisions, were reduced by 25-30% as a result of camera enforcement. PMID:14522657

  1. Time Reversal Violation

    SciTech Connect

    Quinn, H; /SLAC

    2009-01-27

    This talk briefly reviews three types of time-asymmetry in physics, which I classify as universal, macroscopic and microscopic. Most of the talk is focused on the latter, namely the violation of T-reversal invariance in particle physics theories. In sum tests of microscopic T-invariance, or observations of its violation, are limited by the fact that, while we can measure many processes, only in very few cases can we construct a matched pair of process and inverse process and observe it with sufficient sensitivity to make a test. In both the cases discussed here we can achieve an observable T violation making use of flavor tagging, and in the second case also using the quantum properties of an antisymmetric coherent state of two B mesons to construct a CP-tag. Both these tagging properties depend only on very general properties of the flavor and/or CP quantum numbers and so provide model independent tests for T-invariance violations. The microscopic laws of physics are very close to T-symmetric. There are small effects that give CP- and T-violating processes in three-generation-probing weak decays. Where a T-violating observable can be constructed we see the relationships between T-violation and CP-violation expected in a CPT conserving theory. These microscopic effects are unrelated to the 'arrow of time' that is defined by increasing entropy, or in the time direction defined by the expansion of our Universe.

  2. Parity violating asymmetry with nuclear medium effects in deep inelastic e → scattering

    NASA Astrophysics Data System (ADS)

    Haider, H.; Sajjad Athar, M.; Singh, S. K.; Ruiz Simo, I.

    2015-08-01

    Recently parity violating asymmetry (APV) in the Deep Inelastic Scattering (DIS) of polarized electrons (e →) from deuterons has been measured at JLab and there exist future plans to measure this asymmetry from nuclear targets. In view of this we study nuclear medium effects in APV in the DIS of e → from some nuclear targets like 12C, 56Fe and 208Pb. The effects of Fermi motion, binding energy and nucleon correlations are taken into account through the nucleon spectral function calculated in a local density approximation for nuclei. The pion and rho cloud contributions have also been taken into account. This model has been earlier used to study nuclear medium effects in the electromagnetic and weak interaction induced processes. The results are presented and discussed in view of the future JLab experiments.

  3. CP violation effects on the neutrino degeneracy parameters in the Early Universe

    NASA Astrophysics Data System (ADS)

    Gava, Jérôme; Volpe, Cristina

    2010-09-01

    We explore possible CP violating effects, coming from the Dirac phase of the Maki-Nakagawa-Sakata-Pontecorvo matrix, on the neutrino degeneracy parameters, at the epoch of Big-Bang nucleosynthesis. We first demonstrate the conditions under which such effects can arise. In particular it requires that the initial muon and tau neutrino degeneracy parameters ξ differ. Then we solve numerically the kinetic equations for the three flavor neutrino density matrix with the goal of quantifying the impact of the Dirac phase on the electron neutrino degeneracy parameter ξν_e. The calculations include the vacuum term, the coupling to matter, the νν interaction and the collisions. Effects on ξν_e up to almost 1% and on Y of about 0.1% are found, depending on the initial conditions.

  4. Abstinence-Only Sex Education: College Students' Evaluations and Responses

    ERIC Educational Resources Information Center

    Gardner, Emily A.

    2015-01-01

    This qualitative study explores the abstinence-only sex education experiences of a small group of young adults in the southeastern USA. Most participants felt that their abstinence-only sex education had mixed value and low overall impact in their lives. Perceptions about abstinence, virginity, and marriage varied significantly from those stressed…

  5. The Impact of Abstinence Education: What Does the Research Say?

    ERIC Educational Resources Information Center

    Young, Michael; Penhollow, Tina

    2006-01-01

    There has long been controversy in this country about the implementation of school-based sexuality education. In recent years, however, the controversy has centered on abstinence education. Critics of abstinence education programs seem to have three major concerns relative to abstinence education programming: (1) promotion of religion; (2)…

  6. Is Trust for Sale? The Effectiveness of Financial Compensation for Repairing Competence- versus Integrity-Based Trust Violations

    PubMed Central

    Haesevoets, Tessa; Reinders Folmer, Chris; Van Hiel, Alain

    2015-01-01

    Despite the popularity of financial compensation as a means for addressing trust violations, the question whether (more) money can indeed buy trust back remains largely unexplored. In the present research, we focus on the role of violation type and compensation size. The results of a scenario study and a laboratory experiment show that financial compensation can effectively promote the restoration of trust for transgressions that indicate a lack of competence. Conversely, for transgressions which signal a lack of integrity, financial compensation is not an effective tool to repair trust. Moreover, our findings indicate that for both violation types, overcompensation has no positive effects on top of the impact of equal compensation. These findings therefore show that when it comes to trust, money cannot buy everything. PMID:26714025

  7. Health Education Curriculum Content--Abstinence

    ERIC Educational Resources Information Center

    North Dakota Department of Public Instruction, 2011

    2011-01-01

    As a result of House Bill 1229, introduced and passed during the 2011 North Dakota legislative session, every school district, both public and nonpublic, must expand health education to include abstinence education, if teaching sexuality education as part of the general health curriculum. This fact sheet provides guidance for districts in meeting…

  8. CP-violating effect of the Th nuclear magnetic quadrupole moment: accurate many-body study of ThO.

    PubMed

    Skripnikov, L V; Petrov, A N; Titov, A V; Flambaum, V V

    2014-12-31

    Investigations of CP violation in the hadron sector may be done using measurements in the ThO molecule. Recent measurements in this molecule improved the limit on the electron electric dipole moment (EDM) by an order of magnitude. Another time-reversal (T) and parity (P)-violating effect in 229ThO is induced by the nuclear magnetic quadrupole moment. We perform nuclear and molecular calculations to express this effect in terms of the strength constants of T, P-odd nuclear forces, neutron EDM, QCD vacuum angle θ, quark EDM, and chromo-EDM. PMID:25615324

  9. CP Violation

    NASA Astrophysics Data System (ADS)

    Bigi, I. I.; Sanda, A. I.

    2009-04-01

    Foreword; Part I. Basics of CP Violation: 1. Prologue; 2. Prelude: C, P and T in classical dynamics; 3. C, P and T in non-relativistic quantum mechanics; 4. C, P and T in relativistic quantum theories; 5. The arrival of strange particles; 6. Quantum mechanics of neutral particles; Part II. Theory and Experiments: 7. The quest for CP violation in K decays - a marathon; 8. The KM implementation of CP violation; 9. The theory of KL → ππ decays; 10. Paradigmatic discoveries in B physics; 11. Let the drama unfold - B CP phenomenology; 12. Rare K and B decays - almost perfect laboratories; 13. CPT violation - could it be in K and B decays?; 14. CP violation in charm decays - the dark horse; 15. The strong CP problem; Part III. Looking Beyond the Standard Model: 16. Quest for CP violation in the neutrino sector; 17. Possible corrections to the KM ansatz: right-handed currents and non-minimal Higgs dynamics; 18. CP violation without nonperturbative dynamics - top quarks and charged leptons; 19. SUSY - providing shelter for Higgs dynamics; 20. Minimal flavour violation and extra dimensions; 21. Baryogenesis in the universe; Part IV. Summary: 11. Summary and Perspectives; References; Index.

  10. The Effect of the Violation of the Assumption of Independence When Combining Correlation Coefficients in a Meta-Analysis.

    ERIC Educational Resources Information Center

    Tracz, Susan M.; Elmore, Patricia B.

    Meta-analysis is a technique for combining the summary statistics from previously conducted research studies to indicate the direction of results and provide an index of the magnitude of effect size. This paper focuses on the effect of the violation of the assumption of independence (that the value of any included statistic is in no way…

  11. Employment-Based Abstinence Reinforcement as a Maintenance Intervention for the Treatment of Cocaine Dependence: A Randomized Controlled Trial

    PubMed Central

    DeFulio, Anthony; Donlin, Wendy D.; Wong, Conrad J.; Silverman, Kenneth

    2009-01-01

    Context: Due to the chronic nature of cocaine dependence, long-term maintenance treatments may be required to sustain abstinence. Abstinence reinforcement is among the most effective means of initiating cocaine abstinence. Practical and effective means of maintaining abstinence reinforcement programs over time are needed. Objective: Determine whether employment-based abstinence reinforcement can be an effective long-term maintenance intervention for cocaine dependence. Design: Participants (N=128) were enrolled in a 6-month job skills training and abstinence initiation program. Participants who initiated abstinence, attended regularly, and developed needed job skills during the first six months were hired as operators in a data entry business and randomly assigned to an employment only (Control, n = 24) or abstinence-contingent employment (n = 27) group. Setting: A nonprofit data entry business. Participants: Unemployed welfare recipients who persistently used cocaine while enrolled in methadone treatment in Baltimore. Intervention: Abstinence-contingent employment participants received one year of employment-based contingency management, in which access to employment was contingent on provision drug-free urine samples under routine and then random drug testing. If a participant provided drug-positive urine or failed to provide a mandatory sample, then that participant received a temporary reduction in pay and could not work until urinalysis confirmed recent abstinence. Main Outcome Measure: Cocaine-negative urine samples at monthly assessments across one year of employment. Results: During the one-year of employment, abstinence-contingent employment participants provided significantly more cocaine-negative urine samples than employment only participants (79.3% and 50.7%, respectively; p = 0.004, OR = 3.73, 95% CI = 1.60 – 8.69). Conclusions: Employment-based abstinence reinforcement that includes random drug testing is effective as a long-term maintenance

  12. Predictors of tobacco smoking abstinence among tuberculosis patients in South Africa.

    PubMed

    Louwagie, Goedele M C; Ayo-Yusuf, Olalekan A

    2015-06-01

    This study examines predictors of smoking cessation in tuberculosis patients with high HIV co-infection rates in a South African primary care setting. Current smokers were randomly allocated to brief motivational interviewing (n = 205) or receipt of a brief message (n = 204). Multi-level logistic regression was performed to identify predictors of sustained 3- and 6-month abstinence and 7-day point prevalence abstinence (PPA) at 1 month, with the facility as a random effect. The intervention was ineffective among smokers with high nicotine-dependence at 1 month, but was effective for all smokers over longer periods. Higher baseline self-efficacy predicted the 1-month 7-day PPA, but not sustained abstinence. HIV-positive participants' odds of sustained abstinence were about three times higher than those of their HIV-negative counterparts. Results support a more intensive motivational intervention and/or coping skills' training to increase self-efficacy and abstinence rates. Tobacco cessation services can be introduced in tuberculosis services where high HIV co-infection rates occur. PMID:25655663

  13. Strongly enhanced effects of Lorentz symmetry violation in entangled Yb+ ions

    NASA Astrophysics Data System (ADS)

    Dzuba, V. A.; Flambaum, V. V.; Safronova, M. S.; Porsev, S. G.; Pruttivarasin, T.; Hohensee, M. A.; Häffner, H.

    2016-05-01

    A number of theories aiming at unifying gravity with other fundamental interactions, including field theory, suggest the violation of Lorentz symmetry. Whereas the energy scale of such strongly Lorentz-symmetry-violating physics is much higher than that attainable at present by particle accelerators, Lorentz violation may nevertheless be detectable via precision measurements at low energies. Here, we carry out a systematic theoretical investigation to identify which atom shows the greatest promise for detecting a Lorentz symmetry violation in the electron-photon sector. We found that the ytterbium ion (Yb+) is an ideal system with high sensitivity, as well as excellent experimental controllability. By applying quantum-information-inspired technology to Yb+, we expect tests of local Lorentz invariance (LLI) violating physics in the electron-photon sector to reach levels of 10-23--five orders of magnitude more sensitive than the current best bounds.

  14. Probing the R-parity violating supersymmetric effects in the exclusive c → d/sℓ+νℓ decays

    NASA Astrophysics Data System (ADS)

    Wang, Ru-Min; Zhu, Jie; Sheng, Jin-Huan; Liu, Mo-Lin; Xu, Yuan-Guo

    2015-12-01

    A lot of branching ratios of the exclusive c → d / sℓ+νℓ (ℓ = e , μ) decays have been quite accurately measured by CLEO-c, BELLE, BABAR, BES(I, II, III), ALEPH and MARKIII Collaborations. We probe the R-parity violating supersymmetric effects in the exclusive c → d / sℓ+νℓ decays. From the latest experimental measurements, we obtain new upper limits on the relevant R-parity violating coupling parameters within the decays, and many upper limits are obtained for the first time. Using the constrained new parameter spaces, we predict the R-parity violating effects on the observables, which have not been measured yet. We find that the R-parity violating effects due to slepton exchange could be large on the branching ratios of Dd/s →e+νe decays and the normalized forward-backward asymmetries of Du/d → π / Kℓ+νℓ as well as Ds → Kℓ+νℓ decays, and the constrained squark exchange couplings have negligible effects in the exclusive c → d / sℓ+νℓ decays. Our results in this work could be used to probe new physics effects in the leptonic decays as well as the semileptonic decays, and will correlate with searches for direct supersymmetric signals at LHC and BESIII.

  15. Amount of earnings during prize contingency management treatment is associated with post-treatment abstinence outcomes

    PubMed Central

    Petry, Nancy M.; Roll, John M.

    2012-01-01

    Contingency management (CM) treatments that provide patients with the opportunity to earn chances of winning prizes of varying magnitudes are becoming increasingly popular. In the CM literature, magnitude of reinforcement is linked with effect sizes, such that CM treatments that provide larger magnitude reinforcement are more efficacious than those that provide lower magnitude reinforcement. With prize CM, even when magnitudes of overall expected prize earnings are constant, some patients win more prizes than others. Thus, patients who win larger overall amounts of prizes during treatment may have better outcomes than those who win fewer prizes. This study evaluated the impact of overall amounts of prizes won on long-term abstinence outcomes. The dollar amount of prizes won during prize CM treatments was determined from 78 cocaine abusing methadone maintenance patients who were randomized to prize CM treatments in three clinical trials. Abstinence three months following the end of the CM intervention was the primary dependent variable. The dollar amount of prizes won during CM treatment was a significant predictor of submission of cocaine-negative urine samples and self reports of cocaine abstinence at the follow-up evaluation, even after controlling for other variables associated with long-term abstinence such as pre-treatment urinalysis results and longest duration of abstinence achieved during treatment. These results suggest that magnitudes of earnings during prize CM may impact outcomes and call for further experimentation of parameters related to the efficacy of prize CM. PMID:21707189

  16. Neonatal Abstinence Syndrome: Presentation and Treatment Considerations.

    PubMed

    Jones, Hendrée E; Kaltenbach, Karol; Johnson, Elisabeth; Seashore, Carl; Freeman, Emily; Malloy, Erin

    2016-01-01

    This clinical case conference discusses the treatment of a pregnant woman with opioid use disorder in a comprehensive care program that includes buprenorphine pharmacotherapy. The presentation summarizes common experiences that pregnant women who receive buprenorphine pharmacotherapy face, and also what their prenatally opioid-exposed children confront in the immediate postpartum period. It describes the elements of a successful comprehensive care model and corollary neonatal abstinence syndrome treatment regimen. Expert commentary is included on issues that arise in the buprenorphine induction and maintenance throughout the prenatal and postpartum periods and in the treatment of co-occurring mental health problems during both the prenatal and postpartum periods, particularly the treatment of depression. There is also expert commentary on the care of opioid-exposed neonates, with attention to the treatment for neonatal abstinence syndrome. PMID:27244045

  17. CP violation

    SciTech Connect

    Gilman, F.J.

    1989-12-01

    Predictions for CP violation in the three generation Standard Model are reviewed based on what is known about the Cabibbo-Kobayashi-Maskawa matrix. Application to the K and B meson systems are emphasized. 43 refs., 13 figs.

  18. Memory for Expectation-Violating Concepts: The Effects of Agents and Cultural Familiarity

    PubMed Central

    Porubanova, Michaela; Shaw, Daniel Joel; McKay, Ryan; Xygalatas, Dimitris

    2014-01-01

    Previous research has shown that ideas which violate our expectations, such as schema-inconsistent concepts, enjoy privileged status in terms of memorability. In our study, memory for concepts that violate cultural (cultural schema-level) expectations (e.g., “illiterate teacher”, “wooden bottle”, or “thorny grass”) versus domain-level (ontological) expectations (e.g., “speaking cat”, “jumping maple”, or “melting teacher”) was examined. Concepts that violate cultural expectations, or counter-schematic, were remembered to a greater extent compared with concepts that violate ontological expectations and with intuitive concepts (e.g., “galloping pony”, “drying orchid”, or “convertible car”), in both immediate recall, and delayed recognition tests. Importantly, concepts related to agents showed a memory advantage over concepts not pertaining to agents, but this was true only for expectation-violating concepts. Our results imply that intuitive, everyday concepts are equally attractive and memorable regardless of the presence or absence of agents. However, concepts that violate our expectations (cultural-schema or domain-level) are more memorable when pertaining to agents (humans and animals) than to non-agents (plants or objects/artifacts). We conclude that due to their evolutionary salience, cultural ideas which combine expectancy violations and the involvement of an agent are especially memorable and thus have an enhanced probability of being successfully propagated. PMID:24714568

  19. Memory for expectation-violating concepts: the effects of agents and cultural familiarity.

    PubMed

    Porubanova, Michaela; Shaw, Daniel Joel; McKay, Ryan; Xygalatas, Dimitris

    2014-01-01

    Previous research has shown that ideas which violate our expectations, such as schema-inconsistent concepts, enjoy privileged status in terms of memorability. In our study, memory for concepts that violate cultural (cultural schema-level) expectations (e.g., "illiterate teacher", "wooden bottle", or "thorny grass") versus domain-level (ontological) expectations (e.g., "speaking cat", "jumping maple", or "melting teacher") was examined. Concepts that violate cultural expectations, or counter-schematic, were remembered to a greater extent compared with concepts that violate ontological expectations and with intuitive concepts (e.g., "galloping pony", "drying orchid", or "convertible car"), in both immediate recall, and delayed recognition tests. Importantly, concepts related to agents showed a memory advantage over concepts not pertaining to agents, but this was true only for expectation-violating concepts. Our results imply that intuitive, everyday concepts are equally attractive and memorable regardless of the presence or absence of agents. However, concepts that violate our expectations (cultural-schema or domain-level) are more memorable when pertaining to agents (humans and animals) than to non-agents (plants or objects/artifacts). We conclude that due to their evolutionary salience, cultural ideas which combine expectancy violations and the involvement of an agent are especially memorable and thus have an enhanced probability of being successfully propagated. PMID:24714568

  20. Decoupling survives inflation: a critical look at effective field theory violations during inflation

    NASA Astrophysics Data System (ADS)

    Avgoustidis, Anastasios; Cremonini, Sera; Davis, Anne-Christine; Ribeiro, Raquel H.; Turzyński, Krzysztof; Watson, Scott

    2012-06-01

    We investigate the validity of effective field theory methods and the decoupling of heavy fields during inflation. Considering models of inflation in which the inflaton is coupled to a heavy (super-Hubble) degree of freedom initially in its vacuum state, we find that violations of decoupling are absent unless there is a breakdown of the slow-roll conditions. Next we allow for a temporary departure from inflation resulting in a period of non-adiabaticity during which effective field theory methods are known to fail. We find that the locality of the event and energy conservation lead to a tight bound on the size of the effects of the heavy field. We discuss the implications for the power spectrum and non-gaussianity, and comment on the connection with recent studies of the dynamics of multi-field inflation models. Our results further motivate the use of effective field theory methods to characterize cosmic inflation, and focus the question of observability of additional degrees of freedom during inflation to near the Hubble scale or below — as anticipated from the Wilsonian notions of decoupling and naturalness.

  1. Manifestations of early brain recovery associated with abstinence from alcoholism.

    PubMed

    Bartsch, Andreas J; Homola, György; Biller, Armin; Smith, Stephen M; Weijers, Heinz-Gerd; Wiesbeck, Gerhard A; Jenkinson, Mark; De Stefano, Nicola; Solymosi, László; Bendszus, Martin

    2007-01-01

    Chronic alcohol abuse results in morphological, metabolic, and functional brain damage which may, to some extent, be reversible with early effects upon abstinence. Although morphometric, spectroscopic, and neuropsychological indicators of cerebral regeneration have been described previously, the overall amount and spatial preference of early brain recovery attained by abstinence and its associations with other indicators of regeneration are not well established. We investigated global and local brain volume changes in a longitudinal two-timepoint study with T1-weighted MRI at admission and after short-term (6-7 weeks) sobriety follow-up in 15 uncomplicated, recently detoxified alcoholics. Volumetric brain gain was related to metabolic and neuropsychological recovery. On admission and after short-term abstinence, structural image evaluation using normalization of atrophy (SIENA), its voxelwise statistical extension to multiple subjects, proton MR spectroscopy (1H-MRS), and neuropsychological tests were applied. Upon short-term sobriety, 1H-MRS levels of cerebellar choline and frontomesial N-acetylaspartate (NAA) were significantly augmented. Automatically detected global brain volume gain amounted to nearly two per cent on average and was spatially significant around the superior vermis, perimesencephalic, periventricular and frontal brain edges. It correlated positively with the percentages of cerebellar and frontomesial choline increase, as detected by 1H-MRS. Moreover, frontomesial NAA gains were associated with improved performance on the d2-test of attention. In 10 age- and gender-matched healthy control subjects, no significant brain volume or metabolite changes were observed. Although cerebral osmotic regulations may occur initially upon sobriety, significant increases of cerebellar choline and frontomesial NAA levels detected at stable brain water integrals and creatine concentrations, serum electrolytes and red blood cell indices in our patient sample

  2. Alcohol liver disease: A review of current therapeutic approaches to achieve long-term abstinence

    PubMed Central

    García, María Luisa Gutiérrez; Blasco-Algora, Sara; Fernández-Rodríguez, Conrado M

    2015-01-01

    Harmful alcohol drinking may lead to significant damage on any organ or system of the body. Alcoholic liver disease (ALD) is the most prevalent cause of advanced liver disease in Europe. In ALD, only alcohol abstinence was associated with a better long-term survival. Therefore, current effective therapeutic strategy should be oriented towards achieving alcohol abstinence or a significant reduction in alcohol consumption. Screening all primary care patients to detect those cases with alcohol abuse has been proposed as population-wide preventive intervention in primary care. It has been suggested that in patients with mild alcohol use disorder the best approach is brief intervention in the primary care setting with the ultimate goal being abstinence, whereas patients with moderate-to-severe alcohol use disorder must be referred to specialized care where detoxification and medical treatment of alcohol dependence must be undertaken. PMID:26229395

  3. A Deposit Contract Method to Deliver Abstinence Reinforcement for Cigarette Smoking

    PubMed Central

    Dallery, Jesse; Meredith, Steven; Glenn, Irene M

    2008-01-01

    Eight smokers were randomly assigned to a deposit contract ($50.00) or to a no-deposit group. Using a reversal design, participants could recoup their deposit (deposit group) or earn vouchers (no-deposit group) for smoking reductions and abstinence (breath carbon monoxide [CO] ≤ 4 parts per million) during treatment phases. Treatment was delivered via a novel Internet-based method to monitor smoking status. Although equivalent decreases in breath CO and abstinence were observed during treatment in both groups, $178.50 in vouchers were distributed to participants in the no-deposit group, whereas a small surplus remained in the deposit group. A deposit contract method may represent a cost-effective model to deliver abstinence reinforcement for cigarette smoking. PMID:19192864

  4. Alcohol liver disease: A review of current therapeutic approaches to achieve long-term abstinence.

    PubMed

    García, María Luisa Gutiérrez; Blasco-Algora, Sara; Fernández-Rodríguez, Conrado M

    2015-07-28

    Harmful alcohol drinking may lead to significant damage on any organ or system of the body. Alcoholic liver disease (ALD) is the most prevalent cause of advanced liver disease in Europe. In ALD, only alcohol abstinence was associated with a better long-term survival. Therefore, current effective therapeutic strategy should be oriented towards achieving alcohol abstinence or a significant reduction in alcohol consumption. Screening all primary care patients to detect those cases with alcohol abuse has been proposed as population-wide preventive intervention in primary care. It has been suggested that in patients with mild alcohol use disorder the best approach is brief intervention in the primary care setting with the ultimate goal being abstinence, whereas patients with moderate-to-severe alcohol use disorder must be referred to specialized care where detoxification and medical treatment of alcohol dependence must be undertaken. PMID:26229395

  5. Methodological aspects in the calculation of parity-violating effects in nuclear magnetic resonance parameters.

    PubMed

    Weijo, Ville; Bast, Radovan; Manninen, Pekka; Saue, Trond; Vaara, Juha

    2007-02-21

    We examine the quantum chemical calculation of parity-violating (PV) electroweak contributions to the spectral parameters of nuclear magnetic resonance (NMR) from a methodological point of view. Nuclear magnetic shielding and indirect spin-spin coupling constants are considered and evaluated for three chiral molecules, H2O2, H2S2, and H2Se2. The effects of the choice of a one-particle basis set and the treatment of electron correlation, as well as the effects of special relativity, are studied. All of them are found to be relevant. The basis-set dependence is very pronounced, especially at the electron correlated ab initio levels of theory. Coupled-cluster and density-functional theory (DFT) results for PV contributions differ significantly from the Hartree-Fock data. DFT overestimates the PV effects, particularly with nonhybrid exchange-correlation functionals. Beginning from third-row elements, special relativity is of importance for the PV NMR properties, shown here by comparing perturbational one-component and various four-component calculations. In contrast to what is found for nuclear magnetic shielding, the choice of the model for nuclear charge distribution--point charge or extended (Gaussian)--has a significant impact on the PV contribution to the spin-spin coupling constants. PMID:17328593

  6. Lorentz-violating gravitoelectromagnetism

    SciTech Connect

    Bailey, Quentin G.

    2010-09-15

    The well-known analogy between a special limit of general relativity and electromagnetism is explored in the context of the Lorentz-violating standard-model extension. An analogy is developed for the minimal standard-model extension that connects a limit of the CPT-even component of the electromagnetic sector to the gravitational sector. We show that components of the post-Newtonian metric can be directly obtained from solutions to the electromagnetic sector. The method is illustrated with specific examples including static and rotating sources. Some unconventional effects that arise for Lorentz-violating electrostatics and magnetostatics have an analog in Lorentz-violating post-Newtonian gravity. In particular, we show that even for static sources, gravitomagnetic fields arise in the presence of Lorentz violation.

  7. Form factor effects in the direct detection of isospin-violating dark matter

    SciTech Connect

    Zheng, Hao; Zhang, Zhen; Chen, Lie-Wen E-mail: malkuth@sjtu.edu.cn

    2014-08-01

    Isospin-violating dark matter (IVDM) provides a possible mechanism to ameliorate the tension among recent direct detection experiments. For IVDM, we demonstrate that the results of direct detection experiments based on neutron-rich target nuclei may depend strongly on the density dependence of the symmetry energy which is presently largely unknown and controls the neutron skin thickness that reflects the relative difference of neutron and proton form factors in the neutron-rich nuclei. In particular, using the neutron and proton form factors obtained from Skyrme-Hartree-Fock calculations by varying the symmetry energy within the uncertainty region set by the latest model-independent measurement of the neutron skin thickness of {sup 208}Pb from PREX experiment at JLab, we find that, for IVDM with neutron-to-proton coupling ratio fixed to f{sub n}/f{sub p}=-0.7, the form factor effect may enhance the sensitivity of Xe-based detectors (e.g., XENON100 and LUX) to the DM-proton cross section by a factor of 3 in the DM mass region constrained by CMDS-II(Si) and even by more than an order of magnitude for heavy DM with mass larger than 80 GeV, compared with the results using the empirical Helm form factor. Our results further indicate that the form factor effect can significantly modify the recoil spectrum of Xe-based detectors for heavy IVDM with f{sub n}/f{sub p}=-0.7.

  8. Effects of therapeutic goal management (TGM) on treatment attendance and drug abstinence among men with co-occurring substance use and axis I mental disorders who are homeless: results of the Birmingham EARTH program

    PubMed Central

    2013-01-01

    Purpose This study describes the implementation and impact of Therapeutic Goal Management (TGM) in a Substance Abuse and Mental Health Services Administration (SAMHSA)-sponsored demonstration project entitled Enhanced Addiction Recovery through Housing (EARTH). Participants The sample included 28 male participants followed at six months who completed some treatment. Forty-three percent were Caucasian, and 57% were African American. The average age of participants was 42 years. Design The relationships between TGM goal achievement, treatment attendance, and drug abstinence outcomes were studied among EARTH program participants who were homeless and met criteria for co-occurring substance use and severe DSM-IV Axis I mental disorders. Results The results revealed an overall drug abstinence rate of 72.4% over six months and significant positive relationships between TGM goal achievement and drug abstinence (r = 0.693) and TGM goal achievement and treatment attendance (r = 0.843). Conclusions This research demonstrated the relationship and potential positive impact of systematically setting, monitoring, and reinforcing personalized goals in multiple life areas on drug abstinence and treatment attendance outcomes among persons who are homeless with co-occurring substance use and other Axis I disorders in a integrated community service delivery program. PMID:24499617

  9. A Randomized Trial of Employment-Based Reinforcement of Cocaine Abstinence in Injection Drug Users

    ERIC Educational Resources Information Center

    Silverman, Kenneth; Wong, Conrad J.; Needham, Mick; Diemer, Karly N.; Knealing, Todd; Crone-Todd, Darlene; Fingerhood, Michael; Nuzzo, Paul; Kolodner, Kenneth

    2007-01-01

    High-magnitude and long-duration abstinence reinforcement can promote drug abstinence but can be difficult to finance. Employment may be a vehicle for arranging high-magnitude and long-duration abstinence reinforcement. This study determined if employment-based abstinence reinforcement could increase cocaine abstinence in adults who inject drugs…

  10. Acceptability of OCT and Abstinence Requirements among Women Participating in Microbicide Safety Trials

    PubMed Central

    Breitkopf, Carmen Radecki; Loza, Melissa; Vincent, Kathleen; Moench, Thomas; Stanberry, Lawrence R.; Rosenthal, Susan L.

    2011-01-01

    Background Developing effective and safe microbicides requires study procedures (e.g. technology used, abstinence requirements, and product use) that are acceptable to participants. Methods Thirty women completed 4 study visits including pelvic examination, colposcopy, optical coherence tomography (OCT), and semi-structured, qualitative interviews. Additional requirements included abstinence (for approximately 16 days) and twice daily vaginal product use (for 5.5 days). Interviews were audio-recorded, transcribed, and analyzed using framework analysis. Themes addressing OCT experiences, acceptability of abstinence, and vaginal product use were examined. Results OCT was viewed favorably as an imaging technology. Some women reported feeling the fiber-optic probe “poking” them and over one-third spontaneously reported feeling pressure or pinching upon rotation of the speculum in connection with the OCT evaluation. Compliance with vaginal gel use was high, but for many women assigned to use a product containing nonoxynol-9 (versus placebo), the post-product use exam was more uncomfortable, relative to the initial exam or one week following product discontinuation. Nearly all women experienced product leakage; acceptability of leakage varied. Two women were not abstinent and several more found abstinence challenging. Some women involved their partner in decision making regarding trial enrollment. Strategies to remain abstinent included participating when the partner was away, avoiding early intimacy, and engaging in alternative sexual activities. Conclusions Qualitative interviews in early-phase studies provide insights and capture information that would be missed by behavioral inference alone. Understanding participant’s experiences is important in order to provide anticipatory guidance and plan future microbicide studies that facilitate adherence with trial requirements. PMID:22183842

  11. A Guided Abstinence Experience to Illustrate Addiction Recovery Principles

    PubMed Central

    2008-01-01

    Objectives To develop and implement an elective pharmacy course that included a guided abstinence experience to illustrate addiction recovery principles. Design A 1-credit elective course to illustrate addiction recovery principles was developed and implemented. The course required students to give up a habit for 6 weeks that was causing them problems, meet weekly to discuss addiction recovery processes, and relate their experiences in a journal. Course grades were determined by class participation, submitted worksheets, and submission of the journal and a paper concerning their role as a pharmacist in dealing with those with addictions and in recovery. Pre- and posttests consisting of addiction case scenarios were used to assess students' application of course material. Assessment Graded course elements, pretesting and posttesting, and student course evaluations indicated that course objectives were met. Over the past 15 years, student enrollment has grown from approximately 10% of pharmacy classes to approximately 50% (average 31 students). Conclusion A guided abstinence experience was an effective tool for teaching pharmacy students the concepts of addiction and recovery. PMID:19002278

  12. Biased Perception of Mean Emotion in Abstinent Heroin Abusers.

    PubMed

    Zhang, Meng; Wang, Xuan; Hu, Chun; Liao, Huayu; Yang, Tong; Shen, Mowei

    2015-01-01

    Although evidence suggests that drug abusers exhibit biases when coding individual emotional facial expressions, little is known about how they process multiple expressions simultaneously. The present study evaluated the mean emotions perceived by abstinent heroin abusers. Male abstinent heroin abusers (AHs) and healthy controls (HCs) were randomly assigned into three emotional conditions (happy, sad, or angry), viewed sets of four faces (Experiment 1) or individual faces (Experiment 2) that varied in emotionality (neutral to happy/sad/angry), and judged whether a test face presented later was more/less emotional than the preceding stimuli. Average points of subjective equality were calculated to reflect participants' biases in perceiving emotions of sets or single faces. Relative to HCs, AHs overestimated mean emotions for sad and angry faces in Experiment 1; however, no such biases were found in Experiment 2. This suggests biased ensemble coding towards negative emotional facial expressions in AHs. Furthermore, when controlling for depression and anxiety, AHs' enhanced perception of mean emotion for angry or sad faces in Experiment 1 decreased, indicating a possible mediating effect of these psychopathological variables in the relationship between drug addiction history and abnormal ensemble processing for sets of emotional expressions. PMID:26595559

  13. Neighborhood Vigilance, Health Locus of Control, and Smoking Abstinence

    PubMed Central

    Reitzel, Lorraine R.; Lahoti, Sejal; Li, Yisheng; Cao, Yumei; Wetter, David W.; Waters, Andrew J.; Vidrine, Jennifer Irvin

    2012-01-01

    Objectives To examine whether health locus of control mediated relations of self-reported neighborhood vigilance and biochemically verified, continuous short-term smoking abstinence among 200 smokers enrolled in a cohort study. Methods A nonparametric bootstrapping procedure was used to assess mediation. Results Health locus of control-chance mediated relations between neighborhood vigilance and smoking abstinence in analyses adjusted for sociodemographics and tobacco dependence (p < .05). Greater vigilance was associated with greater attributions that health was affected by chance, which was associated with a lower likelihood of smoking abstinence. Conclusions Results suggest that neighborhood perceptions influence residents’ attributions for health outcomes, which can affect smoking abstinence. PMID:23985180

  14. The neurobiology of cognitive control in successful cocaine abstinence

    PubMed Central

    Connolly, Colm G.; Foxe, John J.; Nierenberg, Jay; Shpaner, Marina; Garavan, Hugh

    2011-01-01

    Introduction Extensive evidence demonstrates that current cocaine abusers show hypoactivity in anterior cingulate and dorsolateral prefrontal cortex and respond poorly relative to drug-naïve controls on tests of executive function. Relatively little is known about the cognitive sequalae of long-term abstinence in cocaine addicts. Methods Here, we use a GO-NOGO task in which successful performance necessitated withholding a prepotent response to assay cognitive control in short-and long-term abstinent cocaine users (1-5 weeks and 40-102 weeks, respectively). Results We report significantly greater activity in prefrontal, cingulate, cerebellar and inferior frontal gyrii in abstinent cocaine users for both successful response inhibitions and errors of commission. Moreover, this relative hyperactivity was present in both abstinent groups, which, in the presence of comparable behavioral performance, suggests a functional compensation. Conclusions Differences between the short- and long-abstinence groups in the patterns of functional recruitment suggest different cognitive control demands at different stages in abstinence. Short-term abstinence showed increased inhibition-related dorsolateral and inferior frontal activity indicative of the need for increased inhibitory control while long-term abstinence showed increased error-related ACC activity indicative of heightened behavioral monitoring. The results suggest that the integrity of prefrontal systems that underlie cognitive control functions may be an important characteristic of successful long-term abstinence. PMID:21885214

  15. Age-related differences in sequential modulations of problem-size and rule-violation effects during arithmetic problem verification tasks.

    PubMed

    Lemaire, Patrick; Brun, Fleur

    2016-04-01

    Young and older adults were asked to verify true (e.g., 5 × 61 = 305) and false (5 × 61 = 315) arithmetic problems. Half the problems were small (e.g., 5 × 17 = 85) and half were large problems (e.g., 5 × 93 = 465). Half the false problems respected the five rule (i.e., the product of an operand multiplied by five ends with either 5 or 0), and half violated this rule (e.g., 21 × 5 = 115 vs. 21 × 5 = 113). Both young and older adults showed problem-size effects (i.e., they verified small problems more quickly than large problems) and five-rule violation effects (i.e., they verified problem violating five rule more quickly than problems respecting five rule). Moreover, we found sequential modulations of these problem-size and five-rule effects. Problem-size effects were larger on current problems following large problems than after small problems, and five-rule violation effects were larger after problems violating the five rule than after no-rule violation problems. Finally, sequential modulations of problem-size effects were larger in older adults than in young adults, and there were no age-related differences in sequential modulations of five-rule violation effects. These findings speak to the determiners of arithmetic performance, as to how well arithmetic calculation and non-calculation strategies are executed and selected on current problems depends on strategies used with preceding problems. PMID:26515986

  16. The comfort of approach: self-soothing effects of behavioral approach in response to meaning violations

    PubMed Central

    Sleegers, Willem W. A.; Proulx, Travis

    2015-01-01

    People maintain systems of beliefs that provide them with a sense of belongingness, control, identity, and meaning, more generally. Recent research shows that when these beliefs are threatened a syndrome of negatively valenced arousal is evoked that motivates people to seek comfort in their ideologies or other personally valued beliefs. In this paper we will provide an overview of this process and discuss areas for future research. Beginning with the neural foundations of meaning violations, we review findings that show the anterior cingulate cortex is responsible for detecting inconsistencies, and importantly, that this is experienced as aversive. Next, we evaluate the evidential support for a psychophysiological arousal response as measured by cardiography and skin conductance. We discuss how current theorizing proposes that subsequent behavioral approach ameliorates the negative arousal and serves as an effective, well-adapted coping response, but we also aim to further integrate this process in the existing threat-compensation literature. Finally, we speculate on whether approach motivation is likely to result when one feels capable of handling the threat, thereby incorporating the biopsychosocial model that distinguishes between challenge and threat into the motivational threat-response literature. We believe the current literature on threat and meaning has much to offer and we aim to provide new incentives for further development. PMID:25620950

  17. Is Abstinence Education Theory Based? The Underlying Logic of Abstinence Education Programs in Texas

    ERIC Educational Resources Information Center

    Goodson, Patricia; Pruitt, B. E.; Suther, Sandy; Wilson, Kelly; Buhi, Eric

    2006-01-01

    Authors examined the logic (or the implicit theory) underlying 16 abstinence-only-until-marriage programs in Texas (50% of all programs funded under the federal welfare reform legislation during 2001 and 2002). Defined as a set of propositions regarding the relationship between program activities and their intended outcomes, program staff's…

  18. Group-Based Randomized Trial of Contingencies for Health and Abstinence in HIV Patients

    ERIC Educational Resources Information Center

    Petry, Nancy M.; Weinstock, Jeremiah; Alessi, Sheila M.; Lewis, Marilyn W.; Dieckhaus, Kevin

    2010-01-01

    Objective: Contingency management (CM) treatments are usually applied individually for drug abstinence, but CM can also be targeted toward health behaviors and implemented in groups. This study evaluated effects of a group-based CM intervention that focused on reinforcing health behaviors. Method: HIV-positive patients with cocaine or opioid use…

  19. EFFECTS OF TOPIRAMATE ON METHAMPHETAMINE-INDUCED CHANGES IN ATTENTIONAL AND PERCEPTUAL-MOTOR SKILLS OF COGNITION IN RECENTLY ABSTINENT METHAMPHETAMINE-DEPENDENT INDIVIDUALS

    PubMed Central

    Johnson, Bankole A.; Roache, John D.; Ait-Daoud, Nassima; Wells, Lynda T.; Wallace, Christopher L.; Dawes, Michael A.; Liu, Lei; Wang, Xin-Qun

    2007-01-01

    Methamphetamine-dependent individuals often cite the need to maintain enhanced cognitive performance and attention as a reason for continuing or relapsing to drug-taking. Further, methamphetamine addicts might not comply with taking a potentially therapeutic medication if it had a profound effect on these cognitive processes. Topiramate, a sulfamate-substituted fructopyranose derivative, has been suggested as a putative therapeutic medication for treating methamphetamine dependence. Examination of topiramate’s effects on cognitive performance and attention is a clinically and scientifically important component of understanding its potential therapeutic profile. In 10 male and female individuals who met DSM-IV criteria for methamphetamine dependence, we examined the effects of low (50 mg b.i.d.)- and high (100 mg b.i.d.)-dose topiramate — in both the presence and absence of low (15 mg)- and high (30 mg)-dose intravenous methamphetamine — on cognitive performance, attention, and concentration on the rapid visual information processing task and the digit symbol substitution test. Intravenous methamphetamine enhanced cognitive performance, attention, and concentration among recently withdrawn methamphetamine addicts — an effect that hitherto had not been well characterized. Topiramate’s cognitive effects were mixed and rather paradoxical, with a tendency to improve attention and concentration both alone and in the presence of methamphetamine while worsening psychomotor retardation. No deleterious interaction occurred between topiramate and methamphetamine on any of these cognitive processes. While clinical studies with topiramate should prepare participants for possible psychomotor retardation, the cognitive-effects profile observed would not likely present an important obstacle to compliance in motivated patients. Topiramate’s complicated cognitive effects among methamphetamine addicts need more comprehensive examination. PMID:16978753

  20. Feeling Abstinent? Feeling Comprehensive? Touching the Affects of Sexuality Curricula

    ERIC Educational Resources Information Center

    Lesko, Nancy

    2010-01-01

    This interpretive study draws on interdisciplinary scholarship on affect and knowledge to ask: toward what feelings do abstinence-only and comprehensive sexuality education curricula direct us? A methodology that is attuned to double exposures is discussed, and one abstinence-only sexuality education curriculum and one comprehensive sexuality…

  1. Evaluation of an Abstinence Based Intervention for Middle School Students

    ERIC Educational Resources Information Center

    Rue, Lisa; Chandran, Raj; Pannu, Aman; Bruce, David; Singh, Rana; Traxler, Karen

    2012-01-01

    Outcomes associated with an abstinence education intervention were evaluated using a single group design with a 12-month longitudinal follow-up. The intervention group of adolescents ages 12-14 years (N = 427) were enrolled in an 11.5-hour abstinence education intervention offered during the school day. Significant differences were found in the…

  2. Should We Be Teaching Sex Education or Sexual Abstinence?

    ERIC Educational Resources Information Center

    Stover, Del

    2007-01-01

    In this article, the author examines the controversial issue whether to teach sex education or sexual abstinence. Sex education has always been fraught with controversy. The discord in Westbrook, Maine, school district is noteworthy because of the vocal support for an abstinence-only curriculum approach to sex education that has reshaped the…

  3. Implementing the Abstinence Education Provision of the Welfare Reform Legislation.

    ERIC Educational Resources Information Center

    Haskins, Ron; Bevan, Carol Statuto

    As part of its 1996 welfare reform bill, the U.S. Congress enacted a $50 million per year program to fund abstinence education. The welfare reform law addresses the problem of births to single adolescents by enforcing child support payments, giving states financial incentives to reduce nonmarital births, and creating the abstinence education…

  4. Citizenship Lessons in Abstinence-Only Sexuality Education

    ERIC Educational Resources Information Center

    Fields, Jessica; Hirschman, Celeste

    2007-01-01

    We examine abstinence-only-until-marriage education as part of a broad effort to reassert the primacy of conventional (hetero) sexual norms. While all sexuality education offers students lessons in "good sexual citizenship," abstinence-only-until-marriage education reserves the rights and responsibilities of membership and belonging for those who…

  5. Defining Sex and Abstinence: Dialogue Is the Key

    ERIC Educational Resources Information Center

    Hamill, Shelley D.; Chepko, Stevie

    2005-01-01

    When does abstinence end and sexual activity begin? In previous generations, the continuum of sexual activity was well-defined in the old baseball analogy. Teens, parents, and teachers knew what going to first, second, or third base involved. For the current generation of young people, sex and abstinence are not so well-defined. As parents and…

  6. Factors Affecting Long-Term Abstinence from Substances Use

    ERIC Educational Resources Information Center

    Elsheikh, Salah Elgaily

    2008-01-01

    Objective: The purpose of this study is to explore the attitudes of abstainers from drug use that relate to the factors leading to long-term abstinence. Materials and Methods: Cross-sectional study was carried out in Al-Amal Hospital to examine, which attitudes of abstainers related to long-term abstinence. A random survey was conducted on 62…

  7. Spinal cord thyrotropin releasing hormone receptors of morphine tolerant-dependent and abstinent rats

    SciTech Connect

    Rahmani, N.H.; Gulati, A.; Bhargava, H.N. )

    1990-07-01

    The effect of chronic administration of morphine and its withdrawal on the binding of 3H-(3-MeHis2)thyrotropin releasing hormone (3H-MeTRH) to membranes of the spinal cord of the rat was determined. Male Sprague-Dawley rats were implanted with either 6 placebo or 6 morphine pellets (each containing 75-mg morphine base) during a 7-day period. Two sets of animals were used. In one, the pellets were left intact at the time of sacrificing (tolerant-dependent) and in the other, the pellets were removed 16 hours prior to sacrificing (abstinent rats). In placebo-pellet-implanted rats, 3H-MeTRH bound to the spinal cord membranes at a single high affinity binding site with a Bmax of 21.3 +/- 1.6 fmol/mg protein, and an apparent dissociation constant Kd of 4.7 +/- 0.8 nM. In morphine tolerant-dependent or abstinent rats, the binding constants of 3H-MeTRH to spinal cord membranes were unaffected. Previous studies from this laboratory indicate that TRH can inhibit morphine tolerance-dependence and abstinence processes without modifying brain TRH receptors. Together with the present results, it appears that the inhibitory effect of TRH on morphine tolerance-dependence and abstinence is probably not mediated via central TRH receptors but may be due to its interaction with other neurotransmitter systems.

  8. Bound on Lorentz and CPT Violating Boost Effects for the Neutron

    NASA Technical Reports Server (NTRS)

    Walsworth, Ronald

    2003-01-01

    A search for a sidereal annual variation in the frequency difference between co-located Xe-129 and He-3 Zeeman masers sets a limit of approximately 10(exp -27) GeV on the coupling of the neutron to the time component of a possible background Lorentz and CPT violating tensor field.

  9. The Effects of Violations of Data Set Assumptions When Using the Oneway, Fixed-Effects Analysis of Variance and the One Concomitant Analysis of Covariance.

    ERIC Educational Resources Information Center

    Johnson, Colleen Cook; Rakow, Ernest A.

    1994-01-01

    This research is an empirical study, through Monte Carlo simulation, of the effects of violations of the assumptions for the oneway fixed-effects analysis of variance (ANOVA) and analysis of covariance (ANCOVA). Research reaffirms findings of previous studies that suggest that ANOVA and ANCOVA be avoided when group sizes are not equal. (SLD)

  10. Changes in cerebral CB1 receptor availability after acute and chronic alcohol abuse and monitored abstinence.

    PubMed

    Ceccarini, Jenny; Hompes, Titia; Verhaeghen, Anne; Casteels, Cindy; Peuskens, Hendrik; Bormans, Guy; Claes, Stephan; Van Laere, Koen

    2014-02-19

    Involvement of the type 1 cannabinoid receptor (CB1R) in the effects of alcohol on the brain is supported by animal experiments, but how in vivo CB1R levels are altered in alcoholic patients is still unclear. To assess the short-time effects of a binge drinking episode on CB1R availability, 20 healthy social drinkers underwent [(18)F]MK-9470-positron emission tomography (PET) at baseline and after intravenous ethanol administration (ALC ACU). Moreover, 26 alcoholic patients underwent sequential CB1R PET after chronic heavy drinking (ALC CHR) and after 1 month of abstinence (ALC ABST). Seventeen healthy subjects served as controls. Compared with baseline, ALC ACU resulted in a global increase of CB1R availability (+15.8%). In contrast, a global decreased CB1R availability was found in ALC CHR patients (-16.1%) compared with controls, which remained unaltered after abstinence (-17.0%). Voxel-based analysis showed that ALC CHR patients had reduced CB1R availability, especially in the cerebellum and parieto-occipital cortex. After abstinence, reduced CB1R availability extended also to other areas such as the ventral striatum and mesotemporal lobe. In conclusion, whereas the acute alcohol effect is an increase in CB1R availability, chronic heavy drinking leads to reduced CB1R availability that is not reversible after 1 month of abstinence. Longer follow-up is required to differentiate whether this is a compensatory effect of repeated endocannabinoid overstimulation or an enduring trait-like feature. An enhanced CB1R signaling may offer a new therapeutic direction for treatment of the negative affective state produced by alcohol withdrawal and abstinence, which is critical for the maintenance of alcohol addiction. PMID:24553924

  11. Chiral effective field theory analysis of hadronic parity violation in few-nucleon systems

    SciTech Connect

    Viviani, Michele; Baroni, Alessandro; Girlanda, Luca; Kievsky, Alejandro; Marcucci, Laura E.; Schiavilla, Rocco

    2014-06-01

    Background: Weak interactions between quarks induce a parity-violating (PV) component in the nucleonnucleon potential, whose effects are currently being studied in a number of experiments involving few-nucleon systems. In the present work, we reconsider the derivation of this PV component within a chiral effective field theory (chiEFT) framework. Purpose: The objectives of the present work are twofold. The first is to perform a detailed analysis of the PV nucleon-nucleon potential up to next-to-next-to-leading (N2LO) order in the chiral expansion, in particular, by determining the number of independent low-energy constants (LECs) at N2LO. The second objective is to investigate PV effects in a number of few-nucleon observables, including the p-p longitudinal asymmetry, the neutron spin rotation in n-p and n-d scattering, and the longitudinal asymmetry in the {sup 3}He( {vector n},p){sup 3}H chargeexchange reaction. Methods: The chiEFT PV potential includes one-pion-exchange, two-pion-exchange, and contact terms as well as 1/M (M being the nucleon mass) nonstatic corrections. Dimensional regularization is used to renormalize pion loops. The wave functions for the A = 2–-4 nuclei are obtained by using strong two- and three-body potentials also derived, for consistency, from chiEFT. In the case of the A = 3–-4 systems, the wave functions are computed by expanding on a hyperspherical harmonics functions basis. Results: We find that the PV potential at N2LO depends on six LECs: the pion-nucleon PV coupling constant h^1_pi and five parameters multiplying contact interactions. An estimate for the range of values of the various LECs is provided by using available experimental data, and these values are used to obtain predictions for the other PV observables. Conclusions: The chiEFT approach provides a very satisfactory framework to analyze PV effects in few-nucleon systems.

  12. A Cautionary Tale About Conducting Research on Abstinence Education: How Do State Abstinence Coordinators Define "Sexual Activity?"

    ERIC Educational Resources Information Center

    Bailey, William; Young, Michael; Knickerbocker, Cliff; Doan, Tam

    2002-01-01

    Investigated how state coordinators of abstinence education programs defined "sexual activity." Researchers surveyed Title V abstinence education coordinators from the 50 states, the District of Columbia, and three territories. Of the 17 coordinators providing at least partial responses, none reported having a definition of sexual activity. The…

  13. Stress enhances retrieval of drug-related memories in abstinent heroin addicts.

    PubMed

    Zhao, Li-Yan; Shi, Jie; Zhang, Xiao-Li; Epstein, David H; Zhang, Xiang-Yang; Liu, Yu; Kosten, Thomas R; Lu, Lin

    2010-02-01

    Stress is associated with relapse to drugs after abstinence, but the mechanisms for this association are unclear. One mechanism may be that stress enhances abstinent addicts' recall of memories of drugs as stress relievers. This study assessed the effects of stress on free recall and cued recall of 10 heroin-related and 10 neutral words learned 24 h earlier by 102 abstinent heroin addicts. These participants were randomly assigned to three experiments that also assessed attention and working memory. Experiment 1 used a psychosocial stressor (Trier social stress test (TSST)) before testing for recall of heroin-related words. Experiment 2 added administration of the beta-adrenoceptor antagonist propranolol 1 h before the psychosocial stressor. Experiment 3 added administration of either cortisol with propranolol, cortisol alone, or propranolol alone 1 h before word recall to determine whether stress enhancement of heroin-related word recall required noradrenergic-glucocorticoid interactions. We found that free recall of heroin-related words in abstinent addicts was enhanced after stress or cortisol administration when compared with a non-stress condition or placebo, respectively, whereas these interventions had no effect on neutral word recall. beta-adrenergic blockade blocked the enhancing effect of stress or cortisol on free recall of heroin-related words. Neither stress nor cortisol affected cued recall, attention, or working memory. The potential of beta-adrenergic blockade to reduce or block stress-induced enhancement of drug-related memory retrieval may be relevant to preventing stress-induced relapse in abstinent heroin addicts. PMID:19890257

  14. Online Community Use Predicts Abstinence in Combined Internet/Phone Intervention for Smoking Cessation

    PubMed Central

    Papandonatos, George D.; Erar, Bahar; Stanton, Cassandra A.; Graham, Amanda L.

    2016-01-01

    Objective To estimate the causal effects of online community use on 30-day point prevalence abstinence at 3 months among smokers randomized to combined Internet+Phone intervention for smoking cessation. Method Participants were N=399 adult smokers in the Internet+Phone arm of The iQUITT Study, a randomized trial of Internet and proactive telephone counseling for smoking cessation. All participants accessed a web-based smoking-cessation program with an established online community and received telephone counseling. Automated tracking metrics of passive (e.g., reading posts, viewing profiles) and active (e.g., writing posts, sending messages) community use were extracted at 3 months. Self-selected community use defines the groups of interest: None, Passive, and Both (passive+active). Inverse probability of treatment weighting corrected for baseline imbalances on demographic, smoking, and psychosocial variables. Propensity weights estimated via generalized boosted models were used to calculate Average Treatment Effects (ATE) and Average Treatment effects on the Treated (ATT). Results Patterns of community use were: None=145 (36.3%), Passive=82 (20.6%), and Both=172 (43.1%). ATE-weighted abstinence rates were: None=12.2% (95% CI=6.7–17.7); Passive=25.2% (95% CI=15.1–35.2); Both=35.5% (95% CI=28.1–42.9). ATT-weighted abstinence rates indicated even greater benefits of passive community use by non-users. Conclusions More than one third of participants who received telephone counseling and used the community both passively and actively achieved abstinence. Participation in an established online community as part of a combined Internet+phone intervention has the potential to promote short-term abstinence. Results also demonstrated that information and support that originate in the community can serve as a resource for all users. PMID:27100127

  15. Use of an Online Smoking Cessation Community Promotes Abstinence: Results of Propensity Score Weighting

    PubMed Central

    Graham, Amanda L.; Papandonatos, George D.; Erar, Bahar; Stanton, Cassandra A.

    2015-01-01

    Objective To estimate the causal effects of use of an online smoking cessation community on 30-day point prevalence abstinence at 3 months. Methods Participants were N=492 adult current smokers in the enhanced Internet arm of The iQUITT Study, a randomized trial of Internet and telephone treatment for smoking cessation. All participants accessed a web-based smoking-cessation program that included a large, established online community. Automated tracking metrics of passive (e.g., reading forum posts, viewing member profiles) and active (e.g., writing forum posts, sending private messages) community use were extracted from the site at 3 months. Self-selected community use defines the groups of interest: “None”, “Passive”, and “Both” (passive+active). Inverse probability of treatment weighting corrected for baseline imbalances on demographic, smoking, psychosocial, and medical history variables. Propensity weights estimated via generalized boosted models were used to calculate Average Treatment Effects (ATE) and Average Treatment effects on the Treated (ATT). Results Patterns of community use were: None=198 (40.2%), Passive=110 (22.4%), and Both=184 (37.4%). ATE-weighted abstinence rates were: None=4.2% (95% CI=1.5–6.9); Passive=15.1% (95% CI=8.4–21.9); Both=20.4% (95% CI=13.9–26.8). ATT-weighted abstinence rates indicated even greater benefits of community use. Conclusions Community users were more likely to quit smoking at 3 months than nonusers. The estimated benefit from use of online community resources was even larger among subjects with high propensity to use them. No differences in abstinence emerged between passive and passive/active users. Results suggest that lurking in online communities confers specific abstinence benefits. Implications of these findings for online cessation communities are discussed. PMID:26651470

  16. Abstinence-based incentives in methadone maintenance: interaction with intake stimulant test results.

    PubMed

    Stitzer, Maxine L; Peirce, Jessica; Petry, Nancy M; Kirby, Kimberly; Roll, John; Krasnansky, Joseph; Cohen, Allan; Blaine, Jack; Vandrey, Ryan; Kolodner, Ken; Li, Rui

    2007-08-01

    Baseline drug use detected in urine toxicology has been shown to predict drug abuse treatment outcome, including response to contingency management interventions with drug abstinence as their target. This study examined the association between baseline urine test result and treatment outcome in stabilized methadone maintenance patients with ongoing stimulant use to determine whether abstinence incentives were differentially effective in those testing stimulant negative versus positive at study entry. Participants were 386 methadone-maintained patients who took part in a National Drug Abuse Treatment Clinical Trials Network multisite study aimed at reducing stimulant abuse during treatment (J. M. Peirce et al., 2006). At study intake, 24% of participants tested stimulant negative and 76% tested positive. Those testing negative at entry submitted 82% negative urines during the study versus 36% for those testing positive at entry (odds ratio [OR] = 8.67; confidence interval [CI] = 5.81-12.94). Compared with those receiving usual care, the addition of abstinence incentives resulted in a significant increase in stimulant-negative urine samples submitted during the study both for those testing negative at study entry (OR = 2.27; CI = 1.13- 4.75) and for those testing positive (OR = 1.84; CI = 1.25-2.71). These findings suggest that abstinence incentives have significant clinical benefits independent of initial drug use severity among methadone maintenance patients with ongoing stimulant drug use. PMID:17696681

  17. Internet and Telephone Treatment for Smoking Cessation: Mediators and Moderators of Short-Term Abstinence

    PubMed Central

    Papandonatos, George D.; Cobb, Caroline O.; Cobb, Nathan K.; Niaura, Raymond S.; Abrams, David B.; Tinkelman, David G.

    2015-01-01

    Introduction: This study examined mediators and moderators of short-term treatment effectiveness from the iQUITT Study (Quit Using Internet and Telephone Treatment), a 3-arm randomized trial that compared an interactive smoking cessation Web site with an online social network (enhanced Internet) alone and in conjunction with proactive telephone counseling (enhanced Internet plus phone) to a static Internet comparison condition (basic Internet). Methods: The analytic sample was N = 1,236 participants with complete 3-month data on all mediating variables. The primary outcome was 30-day point prevalence abstinence (ppa) at 3 months. Recognizing the importance of temporal precedence in mediation analyses, we also present findings for 6-month outcomes. Purported mediators were treatment utilization and changes in psychosocial constructs. Proposed moderators included baseline demographic, smoking, and psychosocial variables. Mediation analyses examined the extent to which between-arm differences in 30-day ppa could be attributed to differential Web site utilization, telephone counseling, and associated changes in smoking self-efficacy and social support for quitting. Effect modification analyses fitted interactions between treatment and prespecified moderators on abstinence. Results: Significant mediators of 30-day ppa were changes in smoking temptations, quitting confidence, and positive and negative partner support, which were strongly associated with increased Web site utilization. The addition of telephone counseling to an enhanced Web site further improved abstinence rates, partly via an association with increased quitting confidence. Baseline smoking rate was the only significant moderator. Conclusions: Increased treatment utilization and associated changes in several psychosocial measures yielded higher abstinence rates. Findings validate the importance of treatment utilization, smoking self-efficacy, and social support to promote abstinence. PMID:25156528

  18. Neonatal Abstinence Syndrome: Essentials for the Practitioner

    PubMed Central

    Robinson, Christine A.

    2014-01-01

    The incidence of neonatal abstinence syndrome (NAS) has increased dramatically during the past 15 years, likely due to an increase in antepartum maternal opiate use. Optimal care of these patients is still controversial because of the available published literature lacking sufficient sample size, placebo control, and comparative pharmacologic trials. Primary treatment for NAS consists of opioid replacement therapy with either morphine or methadone. Paregoric and tincture of opium have been abandoned because of relative safety concerns. Buprenorphine is emerging as a treatment option with promising initial experience. Adjunctive agents should be considered for infants failing treatment with opioid monotherapy. Traditionally, phenobarbital has been used as adjunctive therapy; however, results of clonidine as adjunctive therapy for NAS appear to be beneficial. Future directions for research in NAS should include validating a simplified scoring tool, conducting comparative studies, exploring home management options, and optimizing management through pharmacogenomics. PMID:25309144

  19. Neonatal abstinence syndrome: essentials for the practitioner.

    PubMed

    Siu, Anita; Robinson, Christine A

    2014-07-01

    The incidence of neonatal abstinence syndrome (NAS) has increased dramatically during the past 15 years, likely due to an increase in antepartum maternal opiate use. Optimal care of these patients is still controversial because of the available published literature lacking sufficient sample size, placebo control, and comparative pharmacologic trials. Primary treatment for NAS consists of opioid replacement therapy with either morphine or methadone. Paregoric and tincture of opium have been abandoned because of relative safety concerns. Buprenorphine is emerging as a treatment option with promising initial experience. Adjunctive agents should be considered for infants failing treatment with opioid monotherapy. Traditionally, phenobarbital has been used as adjunctive therapy; however, results of clonidine as adjunctive therapy for NAS appear to be beneficial. Future directions for research in NAS should include validating a simplified scoring tool, conducting comparative studies, exploring home management options, and optimizing management through pharmacogenomics. PMID:25309144

  20. Energy dependence of the parity-violating asymmetry of circularly polarized photons in dγ-> --> np in pionless effective field theory

    NASA Astrophysics Data System (ADS)

    Vanasse, Jared; Schindler, Matthias

    2015-10-01

    At low energies parity-violating interactions between nucleons are described by five low energy constants. The aim of hadronic parity-violation is to cleanly obtain these from experiment, for which few-body systems and pionless effective field theory are ideally suited. In this talk I will discuss the calculation of the parity violating asymmetry in the cross sections for circularly polarized photons on an unpolarized deuteron target in dγ-> --> np using pionless effective field theory. Using this calculation with estimates for the parity-violating low energy constants I will show the ideal energy at which such an experiment should be performed. This experiment is of particular interest as it is a possible future experiment at an upgraded High Intensity Gamma-Ray Source at the Triangle Universities Nuclear Laboratory.

  1. Methamphetamine Dependence and Neuropsychological Functioning: Evaluating Change During Early Abstinence*

    PubMed Central

    Simon, Sara L.; Dean, Andy C.; Cordova, Xochitl; Monterosso, John R.; London, Edythe D.

    2010-01-01

    Objective: The purpose of this work was to assess neuropsychological functioning of individuals in early abstinence from methamphetamine dependence and to test for cognitive change over the first month of abstinence. Method: Methamphetamine-dependent subjects in very early abstinence from methamphetamine (4–9 days; n = 27) were compared with healthy comparison subjects (n = 28) on a test battery that evaluated five cognitive domains (attention/processing speed, learning/memory, working memory, timed executive functioning, and untimed executive functioning). A subsample of the methamphetamine-dependent subjects (n = 18), who maintained abstinence for 1 month, as well as a subsample of the comparison subjects (n = 21), were retested. Results: At the first assessment, the methamphetamine-dependent subjects showed significantly worse performance than the comparison group on a test of processing speed; they also performed 0.31 SDs worse than the control group on a global battery composite score (p < .05). After a month of abstinence, methamphetamine-dependent subjects demonstrated slightly more cognitive improvement than healthy control subjects on the entire cognitive battery, but this difference did not approach statistical significance (p = .33). Conclusions: Our findings suggest that methamphetamine-dependent subjects do not show considerable cognitive gains in the first month of abstinence. A greater length of abstinence may be needed for cognitive improvement. PMID:20409426

  2. Investigating Group Contingencies to Promote Brief Abstinence from Cigarette Smoking

    PubMed Central

    Meredith, Steven E.; Dallery, Jesse

    2013-01-01

    In contingency management (CM), monetary incentives are contingent on evidence of drug abstinence. Typically, incentives (e.g., “vouchers” exchangeable for goods or services) are contingent on individual performance. We programmed vouchers contingent on group performance to investigate whether these contingencies would promote brief abstinence from cigarette smoking. Thirty-two participants were divided into small teams (n = 3 per team). During three 5-day within-subject experimental conditions, participants submitted video recordings of breath carbon monoxide (CO) measures twice daily via Mōtiv8 Systems™, an Internet-based remote monitoring application. During the interdependent contingency condition, participants earned vouchers each time they and their teammates submitted breath CO samples indicative of abstinence (i.e., negative samples). During the independent contingency condition, participants earned vouchers each time they submitted negative samples, regardless of their teammates' performance. During the no vouchers condition, no monetary incentives were contingent on abstinence. In addition, half of the participants (n = 16) could communicate with their teammates through an online peer support forum. Although forum access did not appear to promote smoking abstinence, monetary incentives did promote brief abstinence. Significantly more negative samples were submitted when vouchers were contingent on individual performance (56%) or team performance (53%) relative to when no vouchers were available (35%; F = 6.9, p = 0.002). The results show that interdependent contingencies can promote brief abstinence from cigarette smoking. Moreover, the results suggest that these contingencies may help lower treatment costs and promote social support. PMID:23421358

  3. ESTIMATES OF PRENATAL ABSTINENCE FROM ALCOHOL: A MATTER OF PERSPECTIVE

    PubMed Central

    Chang, Grace; McNamara, Tay K.; Wilkins-Haug, Louise; Orav, E. John

    2007-01-01

    Abstinence from alcohol has been recommended for both pregnant and pre-conceptional women. The purpose of this study is to compare self and partner reports of abstinence from alcohol in a sample of 253 pregnant women who were T-ACE (Tolerance, Annoy, Cut-down, Eye-opener) alcohol screen positive. Dyads’ reports of the women’s abstinence from alcohol before, during, and after pregnancy were compared. Based on their own self-report, less than 20% of the pregnant women were abstinent in their first trimester and about half were abstinent for the rest of their pregnancy. Partners significantly over-estimated the women’s abstinence from alcohol at all points except in the post-partum period when the dyad had the highest rate of agreement (85.4%). Reasons for the discrepancies in the self and partner reports of prenatal abstinence, and how partners might influence such behavior remain speculative, but identify areas for future research and prevention. PMID:17187936

  4. Smoking Abstinence-related Expectancies among American Indians, African Americans, and Women: Potential Mechanisms of Tobacco-related Disparities

    PubMed Central

    Hendricks, Peter S.; Westmaas, J. Lee; Park, Van M. Ta; Thorne, Christopher B.; Wood, Sabrina B.; Baker, Majel R.; Lawler, R. Marsh; Hooper, Monica Webb; Delucchi, Kevin L.; Hall, Sharon M.

    2014-01-01

    Research has documented tobacco-related health disparities by race and gender. Prior research, however, has not examined expectancies about the smoking cessation process (i.e., abstinence-related expectancies) as potential contributors to tobacco-related disparities in special populations. This cross-sectional study compared abstinence-related expectancies between American Indian (n = 87), African American (n = 151), and White (n = 185) smokers, and between women (n = 231) and men (n = 270) smokers. Abstinence-related expectancies also were examined as mediators of race and gender relationships with motivation to quit and abstinence self-efficacy. Results indicated that American Indians and African Americans were less likely than Whites to expect withdrawal effects, and more likely to expect that quitting would be unproblematic. African Americans also were less likely than Whites to expect smoking cessation interventions to be effective. Compared to men, women were more likely to expect withdrawal effects and weight gain.These expectancy differences mediated race and gender relationships with motivation to quit and abstinence self-efficacy. Findings emphasize potential mechanisms underlying tobacco-related health disparities among American Indians, African Americans, and women, and suggest a number of specific approaches for targeting tobacco dependence interventions to these populations. PMID:23528192

  5. Effects of Type of Agreement Violation and Utterance Position on the Auditory Processing of Subject-Verb Agreement: An ERP Study.

    PubMed

    Dube, Sithembinkosi; Kung, Carmen; Peter, Varghese; Brock, Jon; Demuth, Katherine

    2016-01-01

    Previous ERP studies have often reported two ERP components-LAN and P600-in response to subject-verb (S-V) agreement violations (e.g., the boys (*) runs). However, the latency, amplitude and scalp distribution of these components have been shown to vary depending on various experiment-related factors. One factor that has not received attention is the extent to which the relative perceptual salience related to either the utterance position (verbal inflection in utterance-medial vs. utterance-final contexts) or the type of agreement violation (errors of omission vs. errors of commission) may influence the auditory processing of S-V agreement. The lack of reports on these effects in ERP studies may be due to the fact that most studies have used the visual modality, which does not reveal acoustic information. To address this gap, we used ERPs to measure the brain activity of Australian English-speaking adults while they listened to sentences in which the S-V agreement differed by type of agreement violation and utterance position. We observed early negative and positive clusters (AN/P600 effects) for the overall grammaticality effect. Further analysis revealed that the mean amplitude and distribution of the P600 effect was only significant in contexts where the S-V agreement violation occurred utterance-finally, regardless of type of agreement violation. The mean amplitude and distribution of the negativity did not differ significantly across types of agreement violation and utterance position. These findings suggest that the increased perceptual salience of the violation in utterance final position (due to phrase-final lengthening) influenced how S-V agreement violations were processed during sentence comprehension. Implications for the functional interpretation of language-related ERPs and experimental design are discussed. PMID:27625617

  6. Effects of Type of Agreement Violation and Utterance Position on the Auditory Processing of Subject-Verb Agreement: An ERP Study

    PubMed Central

    Dube, Sithembinkosi; Kung, Carmen; Peter, Varghese; Brock, Jon; Demuth, Katherine

    2016-01-01

    Previous ERP studies have often reported two ERP components—LAN and P600—in response to subject-verb (S-V) agreement violations (e.g., the boys *runs). However, the latency, amplitude and scalp distribution of these components have been shown to vary depending on various experiment-related factors. One factor that has not received attention is the extent to which the relative perceptual salience related to either the utterance position (verbal inflection in utterance-medial vs. utterance-final contexts) or the type of agreement violation (errors of omission vs. errors of commission) may influence the auditory processing of S-V agreement. The lack of reports on these effects in ERP studies may be due to the fact that most studies have used the visual modality, which does not reveal acoustic information. To address this gap, we used ERPs to measure the brain activity of Australian English-speaking adults while they listened to sentences in which the S-V agreement differed by type of agreement violation and utterance position. We observed early negative and positive clusters (AN/P600 effects) for the overall grammaticality effect. Further analysis revealed that the mean amplitude and distribution of the P600 effect was only significant in contexts where the S-V agreement violation occurred utterance-finally, regardless of type of agreement violation. The mean amplitude and distribution of the negativity did not differ significantly across types of agreement violation and utterance position. These findings suggest that the increased perceptual salience of the violation in utterance final position (due to phrase-final lengthening) influenced how S-V agreement violations were processed during sentence comprehension. Implications for the functional interpretation of language-related ERPs and experimental design are discussed. PMID:27625617

  7. Exposure to and Views of Information about Sexual Abstinence among Older Teens

    ERIC Educational Resources Information Center

    Jones, Rachel K.; Biddlecom, Ann E.

    2011-01-01

    There is scant research of adolescents' understanding of abstinence. We conducted interviews with a sample of 58 teens to find out their exposure to abstinence information from a range of sources. Most teens had received abstinence information or messages from school, family members, and friends. For many teens, information about abstinence, or…

  8. Hold the Sex, Please: The Discursive Politics between National and Local Abstinence Education Providers

    ERIC Educational Resources Information Center

    Hess, Amie

    2010-01-01

    There are many assumptions made about the beliefs behind abstinence-only until marriage (AOUM) sex education, yet comparatively little research examining the views of abstinence education providers. Drawing on in-depth interviews with 21 abstinence grantees throughout New York State, I examine how individuals working in abstinence organizations…

  9. Search for Time Reversal Violating Effects: R-Correlation Measurement in Neutron Decay

    PubMed Central

    Bodek, K.; Ban, G.; Beck, M.; Bialek, A.; Bryś, T.; Czarnecki, A.; Fetscher, W.; Gorel, P.; Kirch, K.; Kistryn, St.; Kozela, A.; Kuźniak, M.; Lindroth, A.; Naviliat-Cuncic, O.; Pulut, J.; Serebrov, A.; Severijns, N.; Stephan, E.; Zejma, J.

    2005-01-01

    An experiment aiming at the simultaneous determination of both transversal polarization components of electrons emitted in the decay of free neutrons begins data taking using the polarized cold neutron beam (FUNSPIN) from the Swiss Neutron Spallation Source (SINQ) at the Paul-Scherrer Institute, Villigen. A non-zero value of R due to the e− polarization component, which is perpendicular to the plane spanned by the spin of the decaying neutron and the electron momentum, would signal a violation of time reversal symmetry and thus physics beyond the Standard Model. Present status of the project and the results from analysis of the first data sample will be discussed. PMID:27308168

  10. Small Lorentz violations in quantum gravity: do they lead to unacceptably large effects?

    NASA Astrophysics Data System (ADS)

    Gambini, Rodolfo; Rastgoo, Saeed; Pullin, Jorge

    2011-08-01

    We discuss the applicability of the argument of Collins, Pérez, Sudarsky, Urrutia and Vucetich to loop quantum gravity. This argument suggests that Lorentz violations, even ones that only manifest themselves at energies close to the Planck scale, have significant observational consequences at low energies when one considers perturbative quantum field theory and renormalization. We show that non-perturbative treatments like those of loop quantum gravity may generate deviations of Lorentz invariance of a different type than those considered by Collins et al (2004 Phys. Rev. Lett. 93 191301) that do not necessarily imply observational consequences at low energy.

  11. Controlling decremental and inflationary effects in reliability estimation resulting from violations of assumptions.

    PubMed

    Becker, G

    2001-10-01

    Two assumptions in classical test theory, essential tau-equivalence and independence of measurement errors, when violated may produce attenuated or inflated estimates of reliability, respectively. Inflation stemming from correlated errors can be controlled by a procedure in which systematically created equivalent halves of a given measuring instrument are administered across two occasions. When poor approximations to equivalent halves are constructed for this purpose, however, distortion in the opposite direction may result, being sometimes quite large when measuring instruments are not essentially tau-equivalent (or, at the practical level, unidimensional). The nature of these decrements are discussed and illustrated, and a number of procedures for eliminating them introduced. PMID:11783569

  12. Addiction: From Context-Induced Hedonia to Appetite, Based on Transition of Micro-behaviors in Morphine Abstinent Tree Shrews.

    PubMed

    Duan, Ying; Shen, Fang; Gu, Tingting; Sui, Nan

    2016-01-01

    Drug addiction is viewed as a maladaptive memory induced by contextual cues even in the abstinent state. However, the variations of hedonia and appetite induced by the context during the abstinence have been neglected. To distinguish the representative behaviors between hedonia and appetite, micro-behaviors in abstinent animal such as psycho-activity and drug seeking behaviors were observed in morphine conditioned place preference (CPP). To confirm the different effects of reward between drug and natural reward, a palatable food CPP paradigm was compared in current work. After a 10-day training in CPP with morphine or food, the preference was tested on day 1, 14, 28, and the changes of micro-behaviors were analyzed further. Our data showed that tree shrews treated with morphine performed more jumps on day 1 and more visits to saline paired side on day 28, which indicated a featured behavioral transition from psycho-activity to seeking behavior during drug abstinence. Meanwhile, food-conditioned animals only displayed obvious seeking behaviors in the three tests. The results suggest that the variations of micro-behaviors could imply such a transition from hedonic response to appetitive behaviors during morphine abstinence, which provided a potential behavioral basis for further neural mechanism studies. PMID:27375516

  13. Addiction: From Context-Induced Hedonia to Appetite, Based on Transition of Micro-behaviors in Morphine Abstinent Tree Shrews

    PubMed Central

    Duan, Ying; Shen, Fang; Gu, Tingting; Sui, Nan

    2016-01-01

    Drug addiction is viewed as a maladaptive memory induced by contextual cues even in the abstinent state. However, the variations of hedonia and appetite induced by the context during the abstinence have been neglected. To distinguish the representative behaviors between hedonia and appetite, micro-behaviors in abstinent animal such as psycho-activity and drug seeking behaviors were observed in morphine conditioned place preference (CPP). To confirm the different effects of reward between drug and natural reward, a palatable food CPP paradigm was compared in current work. After a 10-day training in CPP with morphine or food, the preference was tested on day 1, 14, 28, and the changes of micro-behaviors were analyzed further. Our data showed that tree shrews treated with morphine performed more jumps on day 1 and more visits to saline paired side on day 28, which indicated a featured behavioral transition from psycho-activity to seeking behavior during drug abstinence. Meanwhile, food-conditioned animals only displayed obvious seeking behaviors in the three tests. The results suggest that the variations of micro-behaviors could imply such a transition from hedonic response to appetitive behaviors during morphine abstinence, which provided a potential behavioral basis for further neural mechanism studies. PMID:27375516

  14. A Critical Role of Lateral Hypothalamus in Context-Induced Relapse to Alcohol Seeking after Punishment-Imposed Abstinence

    PubMed Central

    Rabei, Rana; Kaganovsky, Konstantin; Caprioli, Daniele; Bossert, Jennifer M.; Bonci, Antonello

    2014-01-01

    In human alcoholics, abstinence is often self-imposed, despite alcohol availability, because of the negative consequences of excessive use. During abstinence, relapse is often triggered by exposure to contexts associated with alcohol use. We recently developed a rat model that captures some features of this human condition: exposure to the alcohol self-administration environment (context A), after punishment-imposed suppression of alcohol self-administration in a different environment (context B), provoked renewal of alcohol seeking in alcohol-preferring P rats. The mechanisms underlying context-induced renewal of alcohol seeking after punishment-imposed abstinence are unknown. Here, we studied the role of the lateral hypothalamus (LH) and its forebrain projections in this effect. We first determined the effect of context-induced renewal of alcohol seeking on Fos (a neuronal activity marker) expression in LH. We next determined the effect of LH reversible inactivation by GABAA + GABAB receptor agonists (muscimol + baclofen) on this effect. Finally, we determined neuronal activation in brain areas projecting to LH during context-induced renewal tests by measuring double labeling of the retrograde tracer cholera toxin subunit B (CTb; injected in LH) with Fos. Context-induced renewal of alcohol seeking after punishment-imposed abstinence was associated with increased Fos expression in LH. Additionally, renewal was blocked by muscimol + baclofen injections into LH. Finally, double-labeling analysis of CTb + Fos showed that context-induced renewal of alcohol seeking after punishment-imposed abstinence was associated with selective activation of accumbens shell neurons projecting to LH. The results demonstrate an important role of LH in renewal of alcohol seeking after punishment-imposed abstinence and suggest a role of accumbens shell projections to LH in this form of relapse. PMID:24872550

  15. A critical role of lateral hypothalamus in context-induced relapse to alcohol seeking after punishment-imposed abstinence.

    PubMed

    Marchant, Nathan J; Rabei, Rana; Kaganovsky, Konstantin; Caprioli, Daniele; Bossert, Jennifer M; Bonci, Antonello; Shaham, Yavin

    2014-05-28

    In human alcoholics, abstinence is often self-imposed, despite alcohol availability, because of the negative consequences of excessive use. During abstinence, relapse is often triggered by exposure to contexts associated with alcohol use. We recently developed a rat model that captures some features of this human condition: exposure to the alcohol self-administration environment (context A), after punishment-imposed suppression of alcohol self-administration in a different environment (context B), provoked renewal of alcohol seeking in alcohol-preferring P rats. The mechanisms underlying context-induced renewal of alcohol seeking after punishment-imposed abstinence are unknown. Here, we studied the role of the lateral hypothalamus (LH) and its forebrain projections in this effect. We first determined the effect of context-induced renewal of alcohol seeking on Fos (a neuronal activity marker) expression in LH. We next determined the effect of LH reversible inactivation by GABAA + GABAB receptor agonists (muscimol + baclofen) on this effect. Finally, we determined neuronal activation in brain areas projecting to LH during context-induced renewal tests by measuring double labeling of the retrograde tracer cholera toxin subunit B (CTb; injected in LH) with Fos. Context-induced renewal of alcohol seeking after punishment-imposed abstinence was associated with increased Fos expression in LH. Additionally, renewal was blocked by muscimol + baclofen injections into LH. Finally, double-labeling analysis of CTb + Fos showed that context-induced renewal of alcohol seeking after punishment-imposed abstinence was associated with selective activation of accumbens shell neurons projecting to LH. The results demonstrate an important role of LH in renewal of alcohol seeking after punishment-imposed abstinence and suggest a role of accumbens shell projections to LH in this form of relapse. PMID:24872550

  16. Characterizing Smoking and Drinking Abstinence from Social Media

    PubMed Central

    Tamersoy, Acar; De Choudhury, Munmun; Chau, Duen Horng

    2015-01-01

    Social media has been established to bear signals relating to health and well-being states. In this paper, we investigate the potential of social media in characterizing and understanding abstinence from tobacco or alcohol use. While the link between behavior and addiction has been explored in psychology literature, the lack of longitudinal self-reported data on long-term abstinence has challenged addiction research. We leverage the activity spanning almost eight years on two prominent communities on Reddit: StopSmoking and StopDrinking. We use the self-reported “badge” information of nearly a thousand users as gold standard information on their abstinence status to characterize long-term abstinence. We build supervised learning based statistical models that use the linguistic features of the content shared by the users as well as the network structure of their social interactions. Our findings indicate that long-term abstinence from smoking or drinking (~one year) can be distinguished from short-term abstinence (~40 days) with 85% accuracy. We further show that language and interaction on social media offer powerful cues towards characterizing these addiction-related health outcomes. We discuss the implications of our findings in social media and health research, and in the role of social media as a platform for positive behavior change and therapy. PMID:26640831

  17. Probing R -parity violating supersymmetric effects in the exclusive b →c ℓ-ν¯ℓ decays

    NASA Astrophysics Data System (ADS)

    Wang, Ru-Min; Zhu, Jie; Gan, Hua-Min; Fan, Ying-Ying; Chang, Qin; Xu, Yuan-Guo

    2016-05-01

    Motivated by recent results from the LHCb, BABAR, and Belle Collaborations on B →D(*)ℓ-ν¯ ℓ decays, which significantly deviate from the Standard Model and hint at the possible new physics beyond the Standard Model, we probe the R -parity violating supersymmetric effects in Bc-→ℓ-ν¯ ℓ and B →D(*)ℓ-ν¯ ℓ decays. We find the following: (i) B (Bc-→e-ν¯ e) and B (Bc-→μ-ν¯ μ) are sensitive to the constrained slepton exchange couplings. (ii) The normalized forward-backward asymmetries of B →D e-ν¯ e decays have been greatly affected by the constrained slepton exchange couplings, and their signs could be changed. (iii) All relevant observables in the exclusive b →c τ-ν¯ τ decays and ratios R (D(*)) are sensitive to the slepton exchange coupling, and R (D*) could be enhanced by the constrained slepton exchange coupling to reach each 95% confidence level experimental ranges from BABAR, Belle, and LHCb but not the lower limit of the 95% confidence level experimental average. Our results in this work could be used to probe R -parity violating effects and will correlate with searches for direct supersymmetric signals at the running LHCb and the forthcoming Belle-II.

  18. A reinforcement-based therapeutic workplace for the treatment of drug abuse: six-month abstinence outcomes.

    PubMed

    Silverman, K; Svikis, D; Robles, E; Stitzer, M L; Bigelow, G E

    2001-02-01

    This study evaluated a novel drug abuse treatment, the Therapeutic Workplace. In this treatment, patients are paid to perform jobs or to participate in job training. Salary is linked to abstinence by requiring patients to provide drug-free urine samples to gain access to the workplace. Pregnant and postpartum drug abuse patients (N = 40) were randomly assigned to a Therapeutic Workplace or usual care control group. Therapeutic Workplace participants were invited to work 3 hr every weekday for 6 months and could earn up to $4,030 in vouchers for abstinence, workplace attendance, and performance. On average, 45% of participants attended the workplace per day. Relative to controls, the Therapeutic Workplace nearly doubled patients' abstinence from opiates and cocaine (33% vs. 59% of thrice-weekly urine samples drug negative, respectively, p < .05). The Therapeutic Workplace can effectively treat heroin and cocaine abuse in pregnant and postpartum women. PMID:11519628

  19. CPT violation implies violation of Lorentz invariance.

    PubMed

    Greenberg, O W

    2002-12-01

    A interacting theory that violates CPT invariance necessarily violates Lorentz invariance. On the other hand, CPT invariance is not sufficient for out-of-cone Lorentz invariance. Theories that violate CPT by having different particle and antiparticle masses must be nonlocal. PMID:12484997

  20. Probing the effects of Lorentz-symmetry violating Chern-Simons and Ricci-Cotton terms in higher derivative gravity

    SciTech Connect

    Pereira-Dias, B.; Hernaski, C. A.; Helayeel-Neto, J. A.

    2011-04-15

    The combined effects of the Lorentz-symmetry violating Chern-Simons and Ricci-Cotton actions are investigated for the Einstein-Hilbert gravity in the second-order formalism modified by higher derivative terms, and their consequences on the spectrum of excitations are analyzed. We follow the lines of previous works and build up an orthonormal basis of projector-like operators for the degrees of freedom, rather than for the spin modes of the fields. With this new basis, the attainment of the propagators is remarkably simplified and the identification of the physical and unphysical modes becomes more immediate. Our conclusion is that the only tachyon- and ghost-free model is the Einstein-Hilbert action added up by the Chern-Simons term with a timelike vector of the type v{sup {mu}=}({mu},0-vector). Spectral consistency imposes that the Ricci-Cotton term must be switched off. We then infer that gravity with Lorentz-symmetry violation imposes a drastically different constraint on the background if compared to ordinary gauge theories whenever conditions for the suppression of tachyons and ghosts are imposed.

  1. A history of chronic morphine exposure during adolescence increases despair-like behaviour and strain-dependently promotes sociability in abstinent adult mice

    PubMed Central

    Lutz, PE; Reiss, D; Ouagazzal, AM; Kieffer, BL

    2013-01-01

    A crucial issue in treating opiate addiction, a chronic relapsing disorder, is to maintain a drug-free abstinent state. Prolonged abstinence associates with mood disorders, strongly contributing to relapse. In particular, substance use disorders occurring during adolescence predispose to depression later in adulthood. Using our established mouse model of opiate abstinence, we characterized emotional consequences into adulthood of morphine exposure during adolescence. Our results indicate that morphine treatment in adolescent mice has no effect on anxiety-like behaviours in adult mice, after abstinence. In contrast, morphine treatment during adolescence increases behavioural despair in adult mice. We also show that morphine exposure strain-dependently enhances sociability in adult mice. Additional research will be required to understand where and how morphine acts during brain maturation to affect emotional and social behaviours into adulthood. PMID:23295400

  2. Intolerance for Smoking Abstinence Questionnaire: Psychometric Properties and Relationship to Tobacco Dependence and Abstinence

    PubMed Central

    Sirota, Alan D.; Rohsenow, Damaris J.; MacKinnon, Selene V.; Martin, Rosemarie A.; Eaton, Cheryl A.; Kaplan, Gary B.; Monti, Peter M.; Tidey, Jennifer W.; Swift, Robert M.

    2013-01-01

    While smokers’ ability to tolerate emotional or physical distress has been associated with length of smoking cessation, there is no measure of ability to tolerate smoking abstinence discomfort specifically, which may be more heuristic than a measure of tolerance of general emotional stress or physical discomfort. Methods Questionnaires completed by 300 smokers assessed inability to tolerate smoking abstinence discomfort (IDQ-S), general physical discomfort (IDQ-P), and general emotional discomfort (IDQ-E), so that shared variance among these measures could be assessed. Results The IDQ-S has three reliable components: Withdrawal Intolerance, Lack of Cognitive Coping, and Pain Intolerance. The 14-item IDQ-P and 9-item IDQ-E each consist of one reliable component. Intercorrelations suggest only modest shared variance. Support for construct and discriminant validity was seen. Two scales of the IDQ-S showed excellent convergent validity, correlating with smoking use, dependence, motivation, and length of past smoking cessation, while IDQ-P and IDQ-E correlated with few indices of use or dependence and not with smoking cessation. Conclusions The final 17-item IDQ-S with two scales is reliable and valid, and more heuristic than measures of general physical or emotional discomfort intolerance as a correlate of motivation and past success with smoking cessation. PMID:20381260

  3. Food addiction: detox and abstinence reinterpreted?

    PubMed

    Shriner, Richard L

    2013-10-01

    The senior patient and/or the geriatrician are confronted with a confusing literature describing how patients interested in combating metabolic syndrome, diabesity (diabetes plus obesity) or simple obesity might best proceed. The present paper gives a brief outline of the basic disease processes that underlie metabolic pro-inflammation, including how one might go about devising the most potent and practical detoxification from such metabolic compromise. The role that dietary restriction plays in pro-inflammatory detoxification (detox), including how a modified fast (selective food abstinence) is incorporated into this process, is developed. The unique aspects of geriatric bariatric medicine are elucidated, including the concepts of sarcopenia and the obesity paradox. Important caveats involving the senior seeking weight loss are offered. By the end of the paper, the reader will have a greater appreciation for the challenges and opportunities that lie ahead for geriatric patients who wish to overcome food addiction and reverse pro-inflammatory states of ill-heath. This includes the toxic metabolic processes that create obesity complicated by type 2 diabetes mellitus (T2DM) which collectively we call diabesity. In that regard, diabesity is often the central pathology that leads to the evolution of the metabolic syndrome. The paper also affords the reader a solid review of the neurometabolic processes that effectuate anorexigenic versus orexigenic inputs to obesity that drive food addiction. We argue that these processes lead to either weight gain or weight loss by a tripartite system involving metabolic, addictive and relational levels of organismal functioning. Recalibrating the way we negotiate these three levels of daily functioning often determines success or failure in terms of overcoming metabolic syndrome and food addiction. PMID:23267844

  4. Abstinence duration modulates striatal functioning during monetary reward processing in cocaine patients.

    PubMed

    Bustamante, Juan-Carlos; Barrós-Loscertales, Alfonso; Costumero, Víctor; Fuentes-Claramonte, Paola; Rosell-Negre, Patricia; Ventura-Campos, Noelia; Llopis, Juan-José; Ávila, César

    2014-09-01

    Pre-clinical and clinical studies in cocaine addiction highlight alterations in the striatal dopaminergic reward system that subserve maintenance of cocaine use. Using an instrumental conditioning paradigm with monetary reinforcement, we studied striatal functional alterations in long-term abstinent cocaine-dependent patients and striatal functioning as a function of abstinence and treatment duration. Eighteen patients and 20 controls underwent functional magnetic resonance imaging during a Monetary Incentive Delay task. Region of interest analyses based on masks of the dorsal and ventral striatum were conducted to test between-group differences and the functional effects in the cocaine group of time (in months) with no more than two lapses from the first time patients visited the clinical service to seek treatment at the scanning time (duration of treatment), and the functional effects of the number of months with no lapses or relapses at the scanning session time (length of abstinence). We applied a voxel-wise and a cluster-wise FWE-corrected level (pFWE) at a threshold of P < 0.05. The patient group showed lower activation in the right caudate during reward anticipation than the control group. The regression analyses in the patients group revealed a positive correlation between duration of treatment and brain activity in the left caudate during reward anticipation. Likewise, length of abstinence negatively correlated with brain activity in the bilateral nucleus accumbens during monetary outcome processing. In conclusion, caudate and nucleus accumbens show a different brain response pattern to non-drug rewards during cocaine addiction, which can be modulated by treatment success. PMID:23445167

  5. Relations among Affect, Abstinence Motivation and Confidence, and Daily Smoking Lapse Risk

    PubMed Central

    Minami, Haruka; Yeh, Vivian M.; Bold, Krysten W.; Chapman, Gretchen B.; McCarthy, Danielle E.

    2016-01-01

    Aims This study tested the hypothesis that changes in momentary affect, abstinence motivation, and confidence would predict lapse risk over the next 12–24 hours using Ecological Momentary Assessment (EMA) data from smokers attempting to quit smoking. Method 103 adult, daily, treatment-seeking smokers recorded their momentary affect, motivation to quit, abstinence confidence, and smoking behaviors in near real time with multiple EMA reports per day using electronic diaries post-quit. Results Multilevel models indicated that initial levels of negative affect were associated with smoking, even after controlling for earlier smoking status, and that short-term increases in negative affect predicted lapses up to 12, but not 24, hours later. Positive affect had significant effects on subsequent abstinence confidence, but not motivation to quit. High levels of motivation appeared to reduce increases in lapse risk that occur over hours while momentary changes in confidence did not predict lapse risk over 12 hours. Conclusion Negative affect had short-lived effects on lapse risk, whereas higher levels of motivation protected against the risk of lapsing that accumulates over hours. An increase in positive affect was associated with greater confidence to quit, but such changes in confidence did not reduce short-term lapse risk, contrary to expectations. Relations observed among affect, cognitions, and lapse seem to depend critically on the timing of assessments. PMID:24955665

  6. Relations among affect, abstinence motivation and confidence, and daily smoking lapse risk.

    PubMed

    Minami, Haruka; Yeh, Vivian M; Bold, Krysten W; Chapman, Gretchen B; McCarthy, Danielle E

    2014-06-01

    This study tested the hypothesis that changes in momentary affect, abstinence motivation, and confidence would predict lapse risk over the next 12-24 hr using Ecological Momentary Assessment (EMA) data from smokers attempting to quit smoking. One hundred and three adult, daily, treatment-seeking smokers recorded their momentary affect, motivation to quit, abstinence confidence, and smoking behaviors in near real time with multiple EMA reports per day using electronic diaries postquit. Multilevel models indicated that initial levels of negative affect were associated with smoking, even after controlling for earlier smoking status, and that short-term increases in negative affect predicted lapses up to 12, but not 24, hr later. Positive affect had significant effects on subsequent abstinence confidence, but not motivation to quit. High levels of motivation appeared to reduce increases in lapse risk that occur over hours although momentary changes in confidence did not predict lapse risk over 12 hr. Negative affect had short-lived effects on lapse risk, whereas higher levels of motivation protected against the risk of lapsing that accumulates over hours. An increase in positive affect was associated with greater confidence to quit, but such changes in confidence did not reduce short-term lapse risk, contrary to expectations. Relations observed among affect, cognitions, and lapse seem to depend critically on the timing of assessments. PMID:24955665

  7. Perceptions about sexual abstinence and knowledge of HIV/AIDS prevention among in-school adolescents in a western Nigerian city

    PubMed Central

    2011-01-01

    who engage in sexual behaviours (P < 0.05). Majority of the FGD discussants suggested the involvement of parents, media, schools, faith-based institutions and non governmental organizations in promoting the adoption of abstinence. Conclusions The sexual abstinence behaviour of young persons is influenced by multiple factors and should be considered in determining the effectiveness of interventions targeting this behaviour. Coherent sexuality education interventions to promote the adoption of abstinence among young people are urgently needed. PMID:21569416

  8. Risky Car Following in Abstinent Users of MDMA

    PubMed Central

    Dastrup, Elizabeth; Lees, Monica; Bechara, Antoine; Dawson, Jeffrey D.; Rizzo, Matthew

    2011-01-01

    Ecstasy (MDMA) use raises concerns because of its association with risky driving. We evaluated driving performance and risk taking in abstinent recreational MDMA users in a simulated car following task that required continuous attention and vigilance. Drivers were asked to follow two car lengths behind a lead vehicle (LV). Three sinusoids generated unpredictable LV velocity changes. Drivers could mitigate risk by following further behind the erratic LV. From vehicle trajectory data we performed a Fourier analysis to derive measures of coherence, gain, and delay. These measures and headway distance were compared between the different groups. All MDMA drivers met coherence criteria indicating cooperation in the car following task. They matched periodic changes in LV velocity similar to controls (abstinent THC users, abstinent alcohol users, and non-drug users), militating against worse vigilance. While all participants traveled approximately 55mph (89kph), the MDMA drivers followed 64m closer to the LV and demonstrated 1.04s shorter delays to LV velocity changes than other driver groups. The simulated car following task safely discriminated between driving behavior in abstinent MDMA users and controls. Abstinent MDMA users do not perform worse than controls, but may assume extra risk. The control theory framework used in this study revealed behaviors that might not otherwise be evident. PMID:20380914

  9. Response inhibition and addiction medicine: from use to abstinence.

    PubMed

    Spechler, Philip A; Chaarani, Bader; Hudson, Kelsey E; Potter, Alexandra; Foxe, John J; Garavan, Hugh

    2016-01-01

    Historically, neuroscientific research into addiction has emphasized affective and reinforcement mechanisms as the essential elements underlying the pursuit of drugs, their abuse, and difficulties associated with abstinence. However, research over the last decade or so has shown that cognitive control systems, associated largely but not exclusively with the frontal lobes, are also important contributors to drug use behaviors. Here, we focus on inhibitory control and its contribution to both current use and abstinence. A body of evidence points to impaired inhibitory abilities across a range of drugs of abuse. Typically, studies suggest that substance-abusing individuals are characterized by relative hypoactivity in brain systems underlying inhibitory control. In contrast, abstinent users tend to show either normal or supernormal levels of activity in the same systems attesting to the importance of inhibitory control in suppressing the drug use urges that plague attempts at abstinence. In this chapter, the brain and behavioral basis of response inhibition will be reviewed, with a focus on neuroimaging studies of response inhibition in current and abstinent drug abusers. PMID:26806775

  10. The ergonomics of dishonesty: the effect of incidental posture on stealing, cheating, and traffic violations.

    PubMed

    Yap, Andy J; Wazlawek, Abbie S; Lucas, Brian J; Cuddy, Amy J C; Carney, Dana R

    2013-11-01

    Research in environmental sciences has found that the ergonomic design of human-made environments influences thought, feeling, and action. In the research reported here, we examined the impact of physical environments on dishonest behavior. In four studies, we tested whether certain bodily configurations-or postures-incidentally imposed by the environment led to increases in dishonest behavior. The first three experiments showed that individuals who assumed expansive postures (either consciously or inadvertently) were more likely to steal money, cheat on a test, and commit traffic violations in a driving simulation. Results suggested that participants' self-reported sense of power mediated the link between postural expansiveness and dishonesty. Study 4 revealed that automobiles with more expansive driver's seats were more likely to be illegally parked on New York City streets. Taken together, the results suggest that, first, environments that expand the body can inadvertently lead people to feel more powerful, and second, these feelings of power can cause dishonest behavior. PMID:24068113

  11. Lorentz Invariance Violation: Modification of the Compton Scattering and the GZK Cutoff and Other Effects

    NASA Astrophysics Data System (ADS)

    Sidharth, B. G.; Das, Abhishek; Roy, Arka Dev

    2016-05-01

    This paper deals with the violation of Lorentz symmetry. The approach is based on Compton scattering which becomes modified due to a modified dispersion relation arising from a minimum spacetime cut off as in modern Quantum Gravity approaches. With this amendment, we find that two high-energy rays of different energies develop a time-lag. This time separation becomes prominent when the energies of the considered photons is ≥ 1 GeV. Extending our approach to gamma rays of cosmic origin we predict that they undergo innumerable such scattering processes before reaching us. Therefore, it accounts for the time-lag phenomena of gamma ray bursts ( GRB)'s which have been claimed to be observed. Also, we find that resorting to the modified Snyder-Sidharth Hamiltonian it is possible to extend the GZK cut off beyond its normal limit, 1020 eV. Some observations of ultra high energy cosmic rays support this. This extends the limits of special theory of relativity.

  12. Effects of neutral Z' boson in Bs→φℓ+ℓ- decay with polarized φ and the unpolarized and polarized CP violation asymmetry

    NASA Astrophysics Data System (ADS)

    Ahmed, Ishtiaq; Aslam, M. Jamil; Paracha, M. Ali

    2014-01-01

    The effects of the new neutral Z' boson in Bs→φℓ+ℓ-, when φ is longitudinal or transverse polarized, are studied. In addition, the implications of the Z' boson on the unpolarized and polarized CP violation asymmetries, with reference to leptons, are also presented. It is observed that the branching ratio with polarized φ is quite sensitive to the Z' contributions which are coming through the modification of the Wilson coefficients C9eff and C10. Moreover, the off-diagonal elements of the chiral Z' couplings contain a new weak phase φsb that provides a new source of CP violation. Keeping in view that in the flavor-changing neutral-current transitions, the CP-violation asymmetries are highly suppressed in the Standard Model, we have studied the unpolarized and polarized CP-violation asymmetries in Bs→φℓ+ℓ- decays. Our results indicate that these CP-violation asymmetries are remarkably significant and can give us hints of any new physics coming through the Z' boson. It is hoped that accurate measurements of these asymmetries will not only help us to establish NP but also give us a chance to determine the precise values of the coupling parameters of the Z' boson.

  13. Study of the CP-violating effects with gg → Η → τ{sup +}τ{sup –} process

    SciTech Connect

    Belyaev, N. L. Konoplich, R. V.

    2015-12-15

    Study of the gg → Η → τ{sup +}τ{sup –} process was performed at Monte Carlo level within the framework of searching for CP-violating effects. The sensitivity of chosen observables to CP-parity of the Higgs boson was demonstrated for hadronic 1-prong τ decays (τ{sup ±} → π{sup ±}, ρ{sup ±}). Monte Carlo samples for the gg → Η → τ{sup +}τ{sup -} process were generated including the parton hadronisation to final state particles. This generation was performed for the Standard Model Higgs boson, the pseudoscalar Higgs boson, the Z → τ{sup +}τ{sup –} background, and mixed CP-states of the Higgs boson.

  14. An endocannabinoid signal associated with desire for alcohol is suppressed in recently abstinent alcoholics

    PubMed Central

    Mangieri, Regina A.; Hong, Kwang-Ik A.

    2009-01-01

    Background Alcoholics report persistent alcohol craving that is heightened by cognitive cues, stressful situations, and abstinence. The role of endogenous cannabinoids in human alcohol craving—though long suspected—remains elusive. Materials and methods We employed laboratory exposure to stress, alcohol cue, and neutral relaxed situations through guided imagery procedures to evoke alcohol desire and craving in healthy social drinkers (n=11) and in treatment-engaged, recently abstinent alcoholic subjects (n=12) and assessed alcohol craving, heart rate, and changes in circulating endocannabinoid levels. Subjective anxiety was also measured as a manipulation check for the procedures. Results In healthy social drinkers, alcohol cue imagery increased circulating levels of the endocannabinoid anandamide, whereas neutral and stress-related imagery had no such effect. Notably, baseline and response anandamide levels in these subjects were negatively and positively correlated with self-reported alcohol craving scores, respectively. Cue-induced increases in heart rate were also correlated with anandamide responses. By contrast, no imagery-induced anandamide mobilization was observed in alcoholics, whose baseline anandamide levels were markedly reduced compared to healthy drinkers and were uncorrelated to either alcohol craving or heart rate. Conclusions The results suggest that plasma anandamide levels provide a marker of the desire for alcohol in social drinkers, which is suppressed in recently abstinent alcoholics. PMID:19343330

  15. The role of BMI change on smoking abstinence in a sample of HIV-infected smokers.

    PubMed

    Buchberg, Meredith K; Gritz, Ellen R; Kypriotakis, George; Arduino, Roberto C; Vidrine, Damon J

    2016-01-01

    The prevalence of cigarette smoking among persons living with HIV/AIDS (PLWHA) is approximately 40%, significantly higher than that of the general population. Identifying predictors of successful smoking cessation for PLWHA is necessary to alleviate the morbidity and mortality associated with smoking in this population. Weight gain has been associated with smoking relapse in the general population, but has not been studied among PLWHA. Data from 474 PLWHA enrolled in a smoking cessation randomized clinical trial were analyzed to examine the effect of BMI change, from baseline to 3-month follow-up, on smoking outcomes using multiple logistic regression. The odds of 7-day smoking abstinence at 3-month follow-up were 4.22 (95% CI = 1.65, 10.82) times higher for participants classified as BMI decrease and 4.22 (95% CI = 1.62, 11.01) times higher for participants classified as BMI increase as compared to participants with a minimal increase or decrease in BMI. In this sample, both weight gain and loss following smoking cessation were significantly associated with abstinence at 3-month follow-up among HIV-infected smokers. Further research and a better understanding of predictors of abstinence will encourage more tailored interventions, with the potential to reduce morbidity and mortality. PMID:26666313

  16. Changing Social Work Students' Attitudes toward Substance Abusers through the Use of an Abstinence Assignment: A Pilot Study

    ERIC Educational Resources Information Center

    Spaid, Wanda M.; Squires, Stuart P.

    2005-01-01

    Per se, increased knowledge about substance abuse has not been effective in altering social workers' negative attitudes towards substance abusers or their failure to recognize or address substance abuse problems among clients. In this paper, we describe an experiential abstinence assignment integrated with the content of an elective substance…

  17. Psychology in School-based Prevention, Early Intervention, Treatment and Abstinence Maintenance: Some Reponses to Marijuana Use in the Schools.

    ERIC Educational Resources Information Center

    Sharp, Robbie N.; McLaughlin, Robert J.; McClanahan, Kimberly K.

    1999-01-01

    Outlines factors to consider when planning prevention, treatment, or abstinence maintenance intervention for drug abuse, particularly marijuana abuse in schools. Discusses literature on effectiveness of anti-drug campaigns on drug use; reviews spectrum of mental health interventions; and provides examples of programming. Examines role that…

  18. CP Violation in B Mesons

    NASA Astrophysics Data System (ADS)

    Roe, Natalie A.

    2001-04-01

    Our world manifestly violates CP, the symmetry between matter and antimatter; there is no observational evidence for any significant amount of antimatter in the Universe. Andrei Sakharov was the first to point out that, in the context of Big Bang theory, a matter-dominated universe requires CP violation at the quantum level. Indeed, CP violation was subsequently observed as a tiny effect in K-meson decays, and it can be naturally accommodated in the Standard Model of fundamental particles with 3 generations of quarks. However, to produce the observed baryon asymmetry, baryogenesis calculations require more CP violation than the Standard Model affords. This is an intriguing puzzle whose solution will require input from both particle physics and cosmology, and it has inspired particle physicists to study CP violation with greater precision in a new generation of experiments. We are now entering this exciting new era in CP violation studies. Several new or upgraded experiments plan a program of detailed measurements of CP violating effects in B mesons. The predicted asymmetries are large, observable in a variety of decay channels, and the theoretical uncertainties are small for the best modes. Some interesting experimental results have recently been announced, and more precise measurements will soon follow. Future experiments are already planned to make even more definitive measurements. In this talk I will review the theoretical predictions and the connection to cosmology, survey the experimental scene, and describe how the study of CP violation in B mesons will allow us to make stringent tests of the Standard Model.

  19. Can intermittent theta burst stimulation as add-on to psychotherapy improve nicotine abstinence? Results from a pilot study.

    PubMed

    Dieler, Alica C; Dresler, Thomas; Joachim, Kathrin; Deckert, Jürgen; Herrmann, Martin J; Fallgatter, Andreas J

    2014-01-01

    Smoking is among the leading causes of mortality worldwide. Discontinuing smoking can increase life expectancy to the presmoking level. Unaided attempts are often ineffective, strengthening the necessity of cognitive-behavioral therapy (CBT), nicotine replacement or pharmacotherapy. Still, relapse rates are high. Recently, a modulation of nicotine craving, which predicts relapse, through transcranial magnetic stimulation to the prefrontal cortex was shown. In a pilot study, we investigated whether 4 sessions of intermittent theta burst stimulation (iTBS) as add-on treatment to CBT reduces nicotine craving and improves long-term abstinence (at 3, 6 and 12 months). Smokers were randomly assigned to a treatment (n = 38) or a sham group (n = 36). Although we did not find reduced craving, we could show higher abstinence rates in the treatment group at 3 months. At 6 and 12 months abstinence rates did not differ significantly. Results at 12 months, however, have to be interpreted cautiously due to significant differences in the dropout rates between the two groups at this time point. We provide first evidence for a beneficial effect of additional iTBS on intermediate nicotine abstinence; however, the low number of iTBS sessions might have prevented longer effects. More lasting effects might be achieved by iTBS maintenance sessions in analogy to the treatment of depression. PMID:24924851

  20. EMPLOYMENT-BASED ABSTINENCE REINFORCEMENT PROMOTES OPIATE AND COCAINE ABSTINENCE IN OUT-OF-TREATMENT INJECTION DRUG USERS

    PubMed Central

    Holtyn, August F.; Koffarnus, Mikhail N.; DeFulio, Anthony; Sigurdsson, Sigurdur O.; Strain, Eric C.; Schwartz, Robert P.; Silverman, Kenneth

    2016-01-01

    We examined the use of employment-based abstinence reinforcement in out-of-treatment injection drug users, in this secondary analysis of a previously reported trial. Participants (N = 33) could work in the therapeutic workplace, a model employment-based program for drug addiction, for 30 weeks and could earn approximately $10 per hr. During a 4-week induction, participants only had to work to earn pay. After induction, access to the workplace was contingent on enrollment in methadone treatment. After participants met the methadone contingency for 3 weeks, they had to provide opiate-negative urine samples to maintain maximum pay. After participants met those contingencies for 3 weeks, they had to provide opiate- and cocaine-negative urine samples to maintain maximum pay. The percentage of drug-negative urine samples remained stable until the abstinence reinforcement contingency for each drug was applied. The percentage of opiate- and cocaine-negative urine samples increased abruptly and significantly after the opiate- and cocaine-abstinence contingencies, respectively, were applied. These results demonstrate that the sequential administration of employment-based abstinence reinforcement can increase opiate and cocaine abstinence among out-of-treatment injection drug users. PMID:25292399

  1. Lorentz violation naturalness revisited

    NASA Astrophysics Data System (ADS)

    Belenchia, Alessio; Gambassi, Andrea; Liberati, Stefano

    2016-06-01

    We revisit here the naturalness problem of Lorentz invariance violations on a simple toy model of a scalar field coupled to a fermion field via a Yukawa interaction. We first review some well-known results concerning the low-energy percolation of Lorentz violation from high energies, presenting some details of the analysis not explicitly discussed in the literature and discussing some previously unnoticed subtleties. We then show how a separation between the scale of validity of the effective field theory and that one of Lorentz invariance violations can hinder this low-energy percolation. While such protection mechanism was previously considered in the literature, we provide here a simple illustration of how it works and of its general features. Finally, we consider a case in which dissipation is present, showing that the dissipative behaviour does not percolate generically to lower mass dimension operators albeit dispersion does. Moreover, we show that a scale separation can protect from unsuppressed low-energy percolation also in this case.

  2. Glutamatergic Neurometabolites during Early Abstinence from Chronic Methamphetamine Abuse

    PubMed Central

    Tobias, Marc C.; Hudkins, Matthew; London, Edythe D.

    2015-01-01

    Background: The acute phase of abstinence from methamphetamine abuse is critical for rehabilitation success. Proton magnetic resonance spectroscopy has detected below-normal levels of glutamate+glutamine in anterior middle cingulate of chronic methamphetamine abusers during early abstinence, attributed to abstinence-induced downregulation of the glutamatergic systems in the brain. This study further explored this phenomenon. Methods: We measured glutamate+glutamine in additional cortical regions (midline posterior cingulate, midline precuneus, and bilateral inferior frontal cortex) putatively affected by methamphetamine. We examined the relationship between glutamate+glutamine in each region with duration of methamphetamine abuse as well as the depressive symptoms of early abstinence. Magnetic resonance spectroscopic imaging was acquired at 1.5 T from a methamphetamine group of 44 adults who had chronically abused methamphetamine and a control group of 23 age-, sex-, and tobacco smoking-matched healthy volunteers. Participants in the methamphetamine group were studied as inpatients during the first week of abstinence from the drug and were not receiving treatment. Results: In the methamphetamine group, small but significant (5–15%, P<.05) decrements (vs control) in glutamate+glutamine were observed in posterior cingulate, precuneus, and right inferior frontal cortex; glutamate+glutamine in posterior cingulate was negatively correlated (P<.05) with years of methamphetamine abuse. The Beck Depression Inventory score was negatively correlated (P<.005) with glutamate+glutamine in right inferior frontal cortex. Conclusions: Our findings support the idea that glutamatergic metabolism is downregulated in early abstinence in multiple cortical regions. The extent of downregulation may vary with length of abuse and may be associated with severity of depressive symptoms emergent in early recovery. PMID:25522400

  3. Trial Protocol: Randomised controlled trial of the effects of very low calorie diet, modest dietary restriction, and sequential behavioural programme on hunger, urges to smoke, abstinence and weight gain in overweight smokers stopping smoking

    PubMed Central

    2010-01-01

    Background Weight gain accompanies smoking cessation, but dieting during quitting is controversial as hunger may increase urges to smoke. This is a feasibility trial for the investigation of a very low calorie diet (VLCD), individual modest energy restriction, and usual advice on hunger, ketosis, urges to smoke, abstinence and weight gain in overweight smokers trying to quit. Methods This is a 3 armed, unblinded, randomized controlled trial in overweight (BMI > 25 kg/m2), daily smokers (CO > 10 ppm); with at least 30 participants in each group. Each group receives identical behavioural support and NRT patches (25 mg(8 weeks),15 mg(2 weeks),10 mg(2 weeks)). The VLCD group receive a 429-559 kcal/day liquid formula beginning 1 week before quitting and continuing for 4 weeks afterwards. The modest energy restricted group (termed individual dietary and activity planning(IDAP)) engage in goal-setting and receive an energy prescription based on individual basal metabolic rate(BMR) aiming for daily reduction of 600 kcal. The control group receive usual dietary advice that accompanies smoking cessation i.e. avoiding feeling hungry but eating healthy snacks. After this, the VLCD participants receive IDAP to provide support for changing eating habits in the longer term; the IDAP group continues receiving this support. The control group receive IDAP 8 weeks after quitting. This allows us to compare IDAP following a successful quit attempt with dieting concurrently during quitting. It also aims to prevent attrition in the unblinded, control group by meeting their need for weight management. Follow-up occurs at 6 and 12 months. Outcome measures include participant acceptability, measured qualitatively by semi-structured interviewing and quantitatively by recruitment and attrition rates. Feasibility of running the trial within primary care is measured by interview and questionnaire of the treatment providers. Adherence to the VLCD is verified by the presence of urinary ketones

  4. Sodium oxybate: a review of its use in alcohol withdrawal syndrome and in the maintenance of abstinence in alcohol dependence.

    PubMed

    Keating, Gillian M

    2014-01-01

    A liquid formulation of sodium oxybate (Alcover(®)), the sodium salt of γ-hydroxybutyric acid (GHB), is approved in Italy and Austria for use in alcohol withdrawal syndrome and for the maintenance of abstinence in alcohol dependence. This article reviews the efficacy and tolerability of sodium oxybate in alcohol withdrawal syndrome and in the maintenance of abstinence in alcohol dependence, as well as summarizing its pharmacological properties. Results of randomized controlled trials indicate that sodium oxybate was at least as effective as diazepam and clomethiazole in patients with alcohol withdrawal syndrome, rapidly alleviating symptoms, and was at least as effective as naltrexone or disulfiram in the maintenance of abstinence in alcohol-dependent patients. Sodium oxybate was generally well tolerated. The risk of sodium oxybate abuse is generally low when it is administered to alcohol-dependent patients at its approved dosage, under the supervision of a designated family member and with continuous strict medical surveillance. However, certain patient groups, such as patients with alcohol dependence and borderline personality disorder or who are in remission from heroin or cocaine addiction, may not be suitable candidates for sodium oxybate therapy because of an increased risk of abuse. In conclusion, sodium oxybate is a useful option for the treatment of alcohol withdrawal syndrome and for the maintenance of abstinence in alcohol dependence. PMID:24307430

  5. An exploratory randomized controlled trial of a novel high-school-based smoking cessation intervention for adolescent smokers using abstinence-contingent incentives and cognitive behavioral therapy

    PubMed Central

    Krishnan-Sarin, Suchitra; Cavallo, Dana A.; Cooney, Judith L.; Schepis, Ty S.; Kong, Grace; Liss, Thomas B.; Liss, Amanda K.; McMahon, Thomas J.; Nich, Charla; Babuscio, Theresa; Rounsaville, Bruce J.; Carroll, Kathleen M.

    2013-01-01

    Background There are few effective smoking cessation interventions for adolescent smokers. We developed a novel intervention to motivate tobacco use behavior change by 1) enhancing desire to quit through the use of abstinence-contingent incentives (CM), 2) increasing cessation skills through the use of cognitive behavioral therapy (CBT), and 3) removing cessation barriers through delivery within high schools. Methods An exploratory four-week, randomized controlled trial was conducted in Connecticut high schools to dismantle the independent and combined effects of CM and CBT; smokers received CM alone, CBT alone, or CM+CBT. Participants included 82 adolescent smokers seeking smoking cessation treatment. The primary outcome was seven-day end-of-treatment (EOT) point prevalence (PP) abstinence, determined using self-reports confirmed using urine cotinine levels. Secondary outcomes included one-day EOT PP abstinence and cigarette use during treatment and follow up. Results Among participants who initiated treatment (n=72), group differences in seven-day EOT-PP abstinence were observed (χ2=10.48, p<0.01) with higher abstinence in the CM+CBT (36.7%) and CM (36.3%) conditions when compared with CBT (0%). One-day EOT-PP abstinence evidenced similar effects (χ2= 10·39, p<0·01; CM+CBT: 43%, CM: 43%, CBT: 4·3%). Survival analyses indicated differences in time to first cigarette during treatment (χ2=8·73, p =·003; CBT: Day 3, CM: Day 9, CM+CBT: Day 20). At one-and three-month follow ups, while no differences were observed, the CM alone group had the slowest increase in cigarette use. Conclusions High-school, incentive-based smoking cessation interventions produce high rates of short-term abstinence among adolescent smokers; adding cognitive behavioral therapy does not appear to further enhance outcomes. PMID:23523130

  6. Abstinence Programs Don't Work, Largest Study to Date Concludes

    ERIC Educational Resources Information Center

    Freking, Kevin

    2007-01-01

    This article reports on a study conducted by Mathematica Policy Research Inc. of students in four abstinence programs, as well as peers from the same communities who did not participate in the abstinence programs. A federally mandated report said that students who participated in sexual-abstinence education programs partially funded by the federal…

  7. Smoking Abstinence-Induced Changes in Resting State Functional Connectivity with Ventral Striatum Predict Lapse During a Quit Attempt.

    PubMed

    Sweitzer, Maggie M; Geier, Charles F; Addicott, Merideth A; Denlinger, Rachel; Raiff, Bethany R; Dallery, Jesse; McClernon, F Joseph; Donny, Eric C

    2016-09-01

    The ventral and dorsal striatum are critical substrates of reward processing and motivation and have been repeatedly linked to addictive disorders, including nicotine dependence. However, little is known about how functional connectivity between these and other brain regions is modulated by smoking withdrawal and may contribute to relapse vulnerability. In the present study, 37 smokers completed resting state fMRI scans during both satiated and 24-h abstinent conditions, prior to engaging in a 3-week quit attempt supported by contingency management. We examined the effects of abstinence condition and smoking outcome (lapse vs non-lapse) on whole-brain connectivity with ventral and dorsal striatum seed regions. Results indicated a significant condition by lapse outcome interaction for both right and left ventral striatum seeds. Robust abstinence-induced increases in connectivity with bilateral ventral striatum were observed across a network of regions implicated in addictive disorders, including insula, superior temporal gyrus, and anterior/mid-cingulate cortex among non-lapsers; the opposite pattern was observed for those who later lapsed. For dorsal striatum seeds, 24-h abstinence decreased connectivity across both groups with several regions, including medial prefrontal cortex, posterior cingulate cortex, hippocampus, and supplemental motor area. These findings suggest that modulation of striatal connectivity with the cingulo-insular network during early withdrawal may be associated with smoking cessation outcomes. PMID:27091382

  8. Alcoholic abstinence in elderly subjects with misuse of alcohol.

    PubMed

    Menecier, Pascal; Verny, Marc; Fernandez, Lydia; Ploton, Louis

    2016-06-01

    Alcohol use disorder does not disappear with aging, neither the associated induced-suffering. While the prevalence of alcohol use disorder still remains around 10% in the subjects over 65 year old age, and daily encountered by hospital or nursing-home caregivers. Alcohol misuse is often overlooked in elderly people, which then obtain lesser care than younger adults although the care prognosis remains as good as or better than before the age of 65, alcoholic abstinence gets always a place among care offers to elders suffering of alcohol use disorders and dependence. However abstinence is a complex notion gathering various representations or meanings, and induces necessary psychological changes. Alcoholic abstinence seems thus to be feared by families or caregivers, because of lack of knowledge about the addictive dimension of the disorder. On behalf of ultimate freedom, and allowing a last pleasure, alcohol use disorders and its associated suffering can be neglected because abstinence is considered as aggressive and harmful. However, modalities of reduction of alcohol consumption as well as access control or regulated supply of alcoholic beverages, keep having a place in graduate care offers. Beyond the choice of decreasing or suppress drinking alcohol beverages, which only are terms or conditions of improvement, the main point remains the improvement of well-fare, quality of life and elders' health. PMID:27277151

  9. Adolescent Heavy Episodic Drinking: Neurocognitive Functioning during Early Abstinence

    PubMed Central

    Winward, Jennifer L.; Hanson, Karen L.; Bekman, Nicole M.; Tapert, Susan F.; Brown, Sandra A.

    2014-01-01

    Introduction The present study investigated the rate and pattern of neuropsychological recovery in heavy episodic drinking teens during the initial days to weeks of abstinence from alcohol. Method Adolescents (ages 16–18) with histories of heavy episodic drinking (HED; N=39) and socio-demographically similar control teens (CON; N=26) were recruited from San Diego area schools. HED and CON were comparable on 5th grade standardized math and language arts test performance to ensure similar functioning prior to onset of substance use. Participants were administered three neuropsychological test batteries with 2-week intervals during a 4-week monitored abstinence period. Results HED teens performed worse overall than CON on tests of prospective memory (p=.005), cognitive switching (p=.039), inhibition task accuracy (p=.001), verbal memory (p's<.045), visuospatial construction (p’s<.043), and language and achievement (p’s<.008). The statistically significant group × time interaction for block design demonstrated normalization within the four weeks of abstinence for the HED (p=.009). Discussion This study identified cognitive performance deficits associated with heavy episodic drinking in adolescence during early abstinence and with sustained 4-week abstention. These findings suggest alcohol-related influences on several underlying brain systems that may predate the onset of alcohol abuse or dependence or take longer than four weeks to recover. PMID:24512674

  10. "Sex Respect": Abstinence Education and Other Deployments for Sexual "Freedom"

    ERIC Educational Resources Information Center

    Jackson, Liz

    2006-01-01

    Those who view the right to a religiously neutral, empirically-based public education as fundamental have been able to do little more than watch in terror as abstinence-only sex education, which excludes information on either safe sex or birth control, has come to prevail in United States (US) schools. Among causes for concern are abstinence…

  11. Sexually Abstinent Adolescents: An 18-Month Follow-Up

    ERIC Educational Resources Information Center

    Blinn-Pike, Lynn; Berger, Thomas J.; Hewett, John; Oleson, Jacob

    2004-01-01

    This study was a longitudinal follow-up of 697 early adolescents from 20 schools in Missouri, investigating students who, in 1997, indicated on a survey of sexual attitudes and behaviors that they had not had sexual intercourse. They completed the Reasons for Abstinence Scale (RAS) by identifying those items that were reasons why they had not had…

  12. Attributions for Abstinence from Illicit Drugs by University Students

    ERIC Educational Resources Information Center

    Rosenberg, Harold; Baylen, Chelsea; Murray, Shanna; Phillips, Kristina; Tisak, Marie S.; Versland, Amelia; Pristas, Erica

    2008-01-01

    Aim: To assess college students' attributions for abstinence from alcohol and illicit drugs. Method: We recruited 125 undergraduates to rate the degree to which each of 41 listed reasons influenced their abstention from six specific substances (alcohol, MDMA/ecstasy, inhalants, cocaine, marijuana, and hallucinogens). Findings: Internal consistency…

  13. Opioid Abstinence Reinforcement Delays Heroin Lapse during Buprenorphine Dose Tapering

    ERIC Educational Resources Information Center

    Greenwald, Mark K.

    2008-01-01

    A positive reinforcement contingency increased opioid abstinence during outpatient dose tapering (4, 2, then 0 mg/day during Weeks 1 through 3) in non-treatment-seeking heroin-dependent volunteers who had been maintained on buprenorphine (8 mg/day) during an inpatient research protocol. The control group (n = 12) received $4.00 for completing…

  14. Internet-based group contingency management to promote smoking abstinence

    PubMed Central

    Dallery, Jesse; Meredith, Steven; Jarvis, Brantley; Nuzzo, Paul A.

    2015-01-01

    Internet-based group contingencies have been shown to promote brief periods of abstinence from cigarette smoking. Under a group contingency, small teams of smokers must collectively meet abstinence goals to receive monetary consequences. The present study investigated two arrangements, one in which all team members had to meet group treatment goals to receive monetary consequences (Full Group), and one in which team members had to meet some group goals and some individual goals to receive these consequences (Mixed Group). Mōtiv8 Systems, an Internet-based remote monitoring platform, was used to collect video-recorded breath carbon monoxide (CO) samples. All team members could communicate with each other via an online discussion forum. During baseline conditions, only 3.3% of CO samples were negative for smoking, which suggests that self-monitoring and access to the online discussion forum were insufficient to initiate abstinence. When the group contingencies were instituted 41.3% of CO samples were negative. There were no statistically significant differences between the two arrangements in the percentage of negative CO samples or point prevalence at the end of treatment or at the 3-month follow-up. Participants posted an average of 25 comments on the discussion forum, most of which were rated as positive by independent observers. The mean cost of vouchers per participant was lower in the Full Group ($33) relative to the Mixed group ($190). The present results replicate and extend previous findings on group contingencies to promote abstinence and social support. PMID:25821915

  15. The Oxytocin Analogue Carbetocin Prevents Emotional Impairment and Stress-Induced Reinstatement of Opioid-Seeking in Morphine-Abstinent Mice

    PubMed Central

    Zanos, Panos; Georgiou, Polymnia; Wright, Sherie R; Hourani, Susanna M; Kitchen, Ian; Winsky-Sommerer, Raphaëlle; Bailey, Alexis

    2014-01-01

    The main challenge in treating opioid addicts is to maintain abstinence due to the affective consequences associated with withdrawal which may trigger relapse. Emerging evidence suggests a role of the neurohypophysial peptide oxytocin (OT) in the modulation of mood disorders as well as drug addiction. However, its involvement in the emotional consequences of drug abstinence remains unclear. We investigated the effect of 7-day opioid abstinence on the oxytocinergic system and assessed the effect of the OT analogue carbetocin (CBT) on the emotional consequences of opioid abstinence, as well as relapse. Male C57BL/6J mice were treated with a chronic escalating-dose morphine regimen (20–100 mg/kg/day, i.p.). Seven days withdrawal from this administration paradigm induced a decrease of hypothalamic OT levels and a concomitant increase of oxytocin receptor (OTR) binding in the lateral septum and amygdala. Although no physical withdrawal symptoms or alterations in the plasma corticosterone levels were observed after 7 days of abstinence, mice exhibited increased anxiety-like and depressive-like behaviors and impaired sociability. CBT (6.4 mg/kg, i.p.) attenuated the observed negative emotional consequences of opioid withdrawal. Furthermore, in the conditioned place preference paradigm with 10 mg/kg morphine conditioning, CBT (6.4 mg/kg, i.p.) was able to prevent the stress-induced reinstatement to morphine-seeking following extinction. Overall, our results suggest that alterations of the oxytocinergic system contribute to the mechanisms underlying anxiety, depression, and social deficits observed during opioid abstinence. This study also highlights the oxytocinergic system as a target for developing pharmacotherapy for the treatment of emotional impairment associated with abstinence and thereby prevention of relapse. PMID:24129263

  16. The oxytocin analogue carbetocin prevents emotional impairment and stress-induced reinstatement of opioid-seeking in morphine-abstinent mice.

    PubMed

    Zanos, Panos; Georgiou, Polymnia; Wright, Sherie R; Hourani, Susanna M; Kitchen, Ian; Winsky-Sommerer, Raphaëlle; Bailey, Alexis

    2014-03-01

    The main challenge in treating opioid addicts is to maintain abstinence due to the affective consequences associated with withdrawal which may trigger relapse. Emerging evidence suggests a role of the neurohypophysial peptide oxytocin (OT) in the modulation of mood disorders as well as drug addiction. However, its involvement in the emotional consequences of drug abstinence remains unclear. We investigated the effect of 7-day opioid abstinence on the oxytocinergic system and assessed the effect of the OT analogue carbetocin (CBT) on the emotional consequences of opioid abstinence, as well as relapse. Male C57BL/6J mice were treated with a chronic escalating-dose morphine regimen (20-100 mg/kg/day, i.p.). Seven days withdrawal from this administration paradigm induced a decrease of hypothalamic OT levels and a concomitant increase of oxytocin receptor (OTR) binding in the lateral septum and amygdala. Although no physical withdrawal symptoms or alterations in the plasma corticosterone levels were observed after 7 days of abstinence, mice exhibited increased anxiety-like and depressive-like behaviors and impaired sociability. CBT (6.4 mg/kg, i.p.) attenuated the observed negative emotional consequences of opioid withdrawal. Furthermore, in the conditioned place preference paradigm with 10 mg/kg morphine conditioning, CBT (6.4 mg/kg, i.p.) was able to prevent the stress-induced reinstatement to morphine-seeking following extinction. Overall, our results suggest that alterations of the oxytocinergic system contribute to the mechanisms underlying anxiety, depression, and social deficits observed during opioid abstinence. This study also highlights the oxytocinergic system as a target for developing pharmacotherapy for the treatment of emotional impairment associated with abstinence and thereby prevention of relapse. PMID:24129263

  17. A critical role of nucleus accumbens dopamine D1-family receptors in renewal of alcohol seeking after punishment-imposed abstinence

    PubMed Central

    Marchant, Nathan J.; Kaganovsky, Konstantin

    2015-01-01

    In humans, places or contexts previously associated with alcohol use often provoke relapse during abstinence. This phenomenon is modeled in laboratory animals using the ABA renewal procedure, where alcohol seeking that is suppressed with extinction training in a context (B) renews when the animal returns to the original training context (A). However, extinction training does not adequately capture the motivation for abstinence in human alcoholics who typically self-initiate abstinence due to the negative consequences of excessive use. We recently developed a procedure to study renewal in laboratory rats after abstinence is imposed by negative consequences (footshock punishment). The mechanisms of renewal of punished alcohol seeking are largely unknown. Here we used the D1-family receptor antagonist SCH 23390 to examine the role of nucleus accumbens (NAc) shell and core dopamine in renewal of alcohol seeking after punishment-imposed abstinence. We trained alcohol preferring ‘P rats’ to self-administer 20% alcohol in context A and subsequently suppressed alcohol taking via response-contingent footshock punishment in context B. We tested the effects of systemic, NAc shell, or NAc core injections of SCH 23390 on renewal of alcohol seeking after punishment-imposed abstinence. We found that both systemic and NAc shell and core injections of SCH 23390 decreased renewal of punished alcohol seeking. Our results demonstrate a critical role of NAc dopamine in renewal of alcohol seeking after punishment-imposed abstinence. We discuss these results in reference to the brain mechanisms of renewal of alcohol seeking after extinction versus punishment. PMID:25914922

  18. Search for parity and time reversal violating effects in HgH: Relativistic coupled-cluster study

    NASA Astrophysics Data System (ADS)

    Sasmal, Sudip; Pathak, Himadri; Nayak, Malaya K.; Vaval, Nayana; Pal, Sourav

    2016-03-01

    The high effective electric field (Eeff) experienced by the unpaired electron in an atom or a molecule is one of the key ingredients in the success of electron electric dipole moment (eEDM) experiment and its precise calculation requires a very accurate theory. We, therefore, employed the Z-vector method in the relativistic coupled-cluster framework and found that HgH has a very large Eeff value (123.2 GV/cm) which makes it a potential candidate for the next generation eEDM experiment. Our study also reveals that it has a large scalar-pseudoscalar (S-PS) P,T -violating interaction constant, Ws = 284.2 kHz. To judge the accuracy of the obtained results, we have calculated parallel and perpendicular magnetic hyperfine structure (HFS) constants and compared with the available experimental values. The results of our calculation are found to be in nice agreement with the experimental values. Therefore, by looking at the HFS results, we can say that both Eeff and Ws values are also very accurate. Further, We have derived the relationship between these quantities and the ratio which will help to get model independent value of eEDM and S-PS interaction constant.

  19. Large loop effects of extra supersymmetric Higgs doublets to CP violation in B{sup 0} mixing

    SciTech Connect

    Kubo, Jisuke; Lenz, Alexander

    2010-10-01

    We consider more than one pair of SU(2){sub L} doublet Higgs supermultiplets in a generic supersymmetric extension of the standard model, and calculate their one-loop contributions to the soft mass insertions {delta}{sub LL} etc. We find that, if large supersymmetry breaking in this sector is realized, the loop effects can give rise to large contributions to the soft mass insertions, meaning that they can generate large flavor-changing neutral currents and CP violations. We apply our result to a recently proposed model based on the discrete Q{sub 6} family group, and calculate the nondiagonal matrix element M{sub 12} of the neutral meson systems. We focus our attention on the extra phases {phi}{sub d,s}{sup {Delta}}in B{sub d,s} mixing and flavor-specific CP asymmetries a{sub sl}{sup d,s} in neutral B decays and obtain values that can be about 1 order of magnitude larger than the standard model predictions. Our final results are comparable with the recent experimental observations at D0 and CDF, but they are still about a factor of 5 smaller than the recently measured dimuon asymmetry from D0.

  20. Search for parity and time reversal violating effects in HgH: Relativistic coupled-cluster study.

    PubMed

    Sasmal, Sudip; Pathak, Himadri; Nayak, Malaya K; Vaval, Nayana; Pal, Sourav

    2016-03-28

    The high effective electric field (Eeff) experienced by the unpaired electron in an atom or a molecule is one of the key ingredients in the success of electron electric dipole moment (eEDM) experiment and its precise calculation requires a very accurate theory. We, therefore, employed the Z-vector method in the relativistic coupled-cluster framework and found that HgH has a very large Eeff value (123.2 GV/cm) which makes it a potential candidate for the next generation eEDM experiment. Our study also reveals that it has a large scalar-pseudoscalar (S-PS) P,T-violating interaction constant, Ws = 284.2 kHz. To judge the accuracy of the obtained results, we have calculated parallel and perpendicular magnetic hyperfine structure (HFS) constants and compared with the available experimental values. The results of our calculation are found to be in nice agreement with the experimental values. Therefore, by looking at the HFS results, we can say that both Eeff and Ws values are also very accurate. Further, We have derived the relationship between these quantities and the ratio which will help to get model independent value of eEDM and S-PS interaction constant. PMID:27036448

  1. Probing violation of the Copernican principle via the integrated Sachs-Wolfe effect

    SciTech Connect

    Tomita, Kenji; Inoue, Kaiki Taro

    2009-05-15

    Recent observational data of supernovae point to {lambda}-dominated flat cosmological models. However, an alternative model in which we happen to live in an underdense region requires no dark energy or modification of gravity. This challenges the Copernican principle. We show that the integrated Sachs-Wolfe (ISW) effect is an excellent discriminator between anti-Copernican inhomogeneous models and the standard Copernican models. As a reference model, we consider an anti-Copernican inhomogeneous model that consists of two inner negatively curved underdense regions and an outer flat Einstein-de Sitter region. We assume that these regions are connected by two thin walls at redshifts z=0.067 and z=0.45. In the inner two regions, the first-order ISW effect is dominant and comparable to that in the concordant flat-{lambda} models. In the outer Einstein-de Sitter region, the first-order ISW effect vanishes but the second-order ISW effect plays a dominant role, while the first-order ISW effect is dominant in the flat-{lambda} models at moderate redshifts. This difference can discriminate the anti-Copernican models from the concordant flat-{lambda} model. At high redshifts, the second-order ISW effect is dominant both in our inhomogeneous model and in the concordant model. In the outer region, moreover, the ISW effect due to large-scale density perturbations with a present matter density contrast {epsilon}{sub m0}<<0.37 is negligible, while the effect due to small-scale density perturbations (such as clusters of galaxies, superclusters, and voids) with {epsilon}{sub m0}>>0.37 would generate anisotropies which are larger than those generated by the ISW effect in the concordant model.

  2. Baclofen promotes alcohol abstinence in alcohol dependent cirrhotic patients with hepatitis C virus (HCV) infection

    PubMed Central

    Leggio, L.; Ferrulli, A.; Zambon, A.; Caputo, F.; Kenna, G.A.; Swift, R.M.; Addolorato, G.

    2016-01-01

    Hepatitis C virus (HCV) and alcoholic liver disease (ALD), either alone or in combination, count for more than two thirds of all liver diseases in the Western world. There is no safe level of drinking in HCV-infected patients and the most effective goal for these patients is total abstinence. Baclofen, a GABAB receptor agonist, represents a promising pharmacotherapy for alcohol dependence (AD). Previously, we performed a randomized clinical trial (RCT), which demonstrated the safety and efficacy of baclofen in patients affected by AD and cirrhosis. The goal of this post-hoc analysis was to explore baclofen's effect in a subgroup of alcohol-dependent HCV-infected cirrhotic patients. Any patient with HCV infection was selected for this analysis. Among the 84 subjects randomized in the main trial, 24 alcohol-dependent cirrhotic patients had a HCV infection; 12 received baclofen 10mg t.i.d. and 12 received placebo for 12-weeks. With respect to the placebo group (3/12, 25.0%), a significantly higher number of patients who achieved and maintained total alcohol abstinence was found in the baclofen group (10/12, 83.3%; p=0.0123). Furthermore, in the baclofen group, compared to placebo, there was a significantly higher increase in albumin values from baseline (p=0.0132) and a trend toward a significant reduction in INR levels from baseline (p=0.0716). In conclusion, baclofen was safe and significantly more effective than placebo in promoting alcohol abstinence, and improving some LFTs (i.e. albumin, INR) in alcohol-dependent HCV-infected cirrhotic patients. Baclofen may represent a clinically relevant alcohol pharmacotherapy for these patients. PMID:22244707

  3. Effects of flavor-symmetry violation from staggered fermion lattice simulations of graphene

    SciTech Connect

    Giedt, Joel; Nayak, Saroj; Skinner, Andrew

    2011-01-15

    We analyze the effects of flavor splitting from staggered fermion lattice simulations of a low-energy effective theory for graphene. Both the unimproved action and the tadpole-improved action with a Naik term show significant flavor-symmetry breaking in the spectrum of the Dirac operator. Note that this is true even in the vicinity of the second-order phase transition point where it has been argued that the flavor-symmetry breaking should be small due to the continuum limit being approached. We show that at weaker couplings the flavor splitting is drastically reduced by stout link smearing, while this mechanism is ineffective at the stronger couplings relevant to suspended graphene. We also measure the average plaquette and describe how it calls for a reinterpretation of previous lattice Monte Carlo simulation results, due to tadpole improvement. After taking into account these effects, we conclude that previous lattice simulations are possibly indicative of an insulating phase, although the effective number of light flavors could be effectively less than two due to the flavor-splitting effects. If that is true, then simulations with truly chiral fermions (such as overlap fermions) are needed in order to settle the question.

  4. Reasons for not drinking and perceived injunctive norms as predictors of alcohol abstinence among college students.

    PubMed

    Rinker, Dipali Venkataraman; Neighbors, Clayton

    2013-07-01

    Few studies have examined the association between reasons for not drinking and social norms among abstinent college students. Research suggests that drinking motives are associated with perceived injunctive norms and drinking. Therefore, it seems likely that reasons for not drinking may also be associated with perceived injunctive norms and abstinence. The aim of this study was to examine the relationship between reasons for not drinking and perceived injunctive norms on alcohol abstinence. Participants were 423 light-drinking and abstinent college students from a public northwestern university who completed online surveys at baseline, 3-, and 6-month follow-up. We examined abstinence as a function of all subscales of the Reasons for Not Drinking scale using logistic regression, as well as conducted two mediational analyses indicating: (1) perceived injunctive norms as a mediator of the relationship between reasons for not drinking and abstinence, and (2) reasons for not drinking as a mediator of the relationship between perceived injunctive norms and abstinence. The Disapproval/Lack of Interest subscale was the only subscale of the Reasons for Not Drinking scale that was significantly associated with 6-month abstinence. Further, Disapproval/Lack of Interest both directly predicted abstinence and indirectly predicted abstinence via perceived injunctive norms. Perceived injunctive norms indirectly predicted abstinence via Disapproval/Lack of Interest, but did not directly predict abstinence. Results suggest that self-defining personal values are an important component of keeping abstaining college students abstinent. These results are discussed with regard to implications for interventions designed specifically for maintaining abstinence throughout college. PMID:23578745

  5. Dopamine D3 and 5-HT1B receptor dysregulation as a result of psychostimulant intake and forced abstinence: Implications for medications development

    PubMed Central

    Neisewander, Janet L.; Cheung, Timothy H. C.; Pentkowski, Nathan S.

    2014-01-01

    Addiction to psychostimulants, including cocaine and amphetamine, is associated with dysregulation of dopamine and serotonin (5-HT) neurotransmitter systems. Neuroadaptations in these systems vary depending on the stage of the drug taking-abstinence-relapse cycle. Consequently, the effects of potential treatments that target these systems may vary depending on whether they are given during abstinence or relapse. In this review, we discuss evidence that dopamine D3 receptors (D3Rs) and 5-HT1B receptors (5-HT1BRs) are dysregulated in response to both chronic psychostimulant use and subsequent abstinence. We then review findings from preclinical self-administration models which support targeting D3Rs and 5-HT1BRs as potential medications for psychostimulant dependence. Potential side effects of the treatments are discussed and attention is given to studies reporting positive treatment outcomes that depend on: 1) whether testing occurs during abstinence versus relapse, 2) whether escalation of drug self-administration has occurred, 3) whether the treatments are given repeatedly, and 4) whether social factors influence treatment outcomes. We conclude that D3/D2 agonists may decrease psychostimulant intake; however, side effects of D3/D2R full agonists may limit their therapeutic potential, whereas D3/D2R partial agonists likely have fewer undesirable side effects. D3-selective antagonists may not reduce psychostimulant intake during relapse, but nonetheless, may decrease motivation for seeking psychostimulants with relatively few side-effects. 5-HT1BR agonists provide a striking example of treatment outcomes that are dependent on the stage of the addiction cycle. Specifically, these agonists initially increase cocaine’s reinforcing effects during maintenance of self-administration, but after a period of abstinence they reduce psychostimulant seeking and the resumption of self-administration. In conclusion, we suggest that factors contributing to dysregulation of

  6. Duration of detection of methamphetamine in hair after abstinence.

    PubMed

    Suwannachom, Natiprada; Thananchai, Thiwaphorn; Junkuy, Anongphan; O'Brien, Timothy E; Sribanditmongkol, Pongruk

    2015-09-01

    Researchers in the field of hair analysis have known for at least two decades that test results for many chemical compounds remain positive for a considerable period of time after subjects have reported cessation of use. These findings were generally based on small sample populations or individual case studies. Within the last decade, hair analyses of larger populations have investigated the phenomenon of residual positives in abstinent individuals in order to determine the period of time required for various compounds to present negative hair test results at internationally accepted cutoff levels. Such data has primarily been used to establish guidelines for retesting former abusers of illicit drugs in order to evaluate claims of abstinence. To date, research has focused on cocaine and opiates. The present study is the first to examine the duration of detection of methamphetamine (MA) and its metabolite amphetamine (AP) in the hair of chronic MA users who recently ceased their consumption of the drug. The study population (n=63) consisted of inpatients at a hospital drug rehabilitation program in Chiang Mai, Thailand. Drug taking behavior was collected by personal interview at the time of enrollment. Subjects provided hair samples at approximately monthly intervals for MA and AP analysis by gas chromatography-mass spectrometry at 0.2ng/mg cutoff levels. The correlation of baseline MA and AP concentrations in hair at the beginning of abstinence with corresponding duration of detection indicated great individual variability for the rate of clearance of MA and AP from hair. In regard to duration of detection, the majority of chronic MA users remained MA positive for up to about 90 days of reported abstinence, but by 120 days, the detection rate had fallen to about 16%. All subjects tested negative for MA after 153 days of abstinence. For AP, the limit of the duration of detection was reached at 106 days. With the adoption of a margin of safety to compensate for

  7. The emotional effects of violations of causality, or How to make a square amusing

    PubMed Central

    Bressanelli, Daniela; Parovel, Giulia

    2012-01-01

    In Michotte's launching paradigm a square moves up to and makes contact with another square, which then moves off more slowly. In the triggering effect, the second square moves much faster than the first, eliciting an amusing impression. We generated 13 experimental displays in which there was always incongruity between cause and effect. We hypothesized that the comic impression would be stronger when objects are perceived as living agents and weaker when objects are perceived as mechanically non-animated. General findings support our hypothesis. PMID:23145274

  8. CPand t violation in neutrino oscillations

    SciTech Connect

    Hisakazu Minakata; Hiroshi Nunokawa; Stephen Parke

    2003-09-18

    In this short lecture, we discuss some basic phenomenological aspects of CP and T violation in neutrino oscillation. Using CP/T trajectory diagrams in the bi-probability space, we try to sketch out some essential features of the interplay between the effect of CP/T violating phase and that of the matter in neutrino oscillation.

  9. Parity violation in low-energy

    SciTech Connect

    Martin Savage

    2001-12-01

    Parity violation in low-energy nuclear observables is included in the pionless effective field theory. The model-independent relation between the parity-violating asymmetry in polarized np -> d gamma and the non-nucleon part of the deuteron anapole moment is discussed. The asymmetry in np -> d gamma computed with KSW power-counting, and recently criticized by Desplanques, is discussed.

  10. 31 CFR 575.202 - Effect of transfers violating the provisions of this part.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... which the Government of Iraq has or has had an interest since such date, is null and void and shall not... property in which the Government of Iraq has an interest, or has had an interest since such date, unless... property in which, on or since the effective date, there existed an interest of the Government of Iraq....

  11. Chirality and gravitational parity violation.

    PubMed

    Bargueño, Pedro

    2015-06-01

    In this review, parity-violating gravitational potentials are presented as possible sources of both true and false chirality. In particular, whereas phenomenological long-range spin-dependent gravitational potentials contain both truly and falsely chiral terms, it is shown that there are models that extend general relativity including also coupling of fermionic degrees of freedom to gravity in the presence of torsion, which give place to short-range truly chiral interactions similar to that usually considered in molecular physics. Physical mechanisms which give place to gravitational parity violation together with the expected size of the effects and their experimental constraints are discussed. Finally, the possible role of parity-violating gravity in the origin of homochirality and a road map for future research works in quantum chemistry is presented. PMID:25919812

  12. Pharmacological Evidence for an Abstinence-Induced Switch in 5-HT1B Receptor Modulation of Cocaine Self-Administration and Cocaine-Seeking Behavior

    PubMed Central

    2013-01-01

    Studies examining serotonin-1B (5-HT1B) receptor manipulations on cocaine self-administration and cocaine-seeking behavior initially seemed discrepant. However, we recently suggested based on viral-mediated 5-HT1B-receptor gene transfer that the discrepancies are likely due to differences in the length of abstinence from cocaine prior to testing. To further validate our findings pharmacologically, we examined the effects of the selective 5-HT1B receptor agonist CP 94,253 (5.6 mg/kg, s.c.) on cocaine self-administration during maintenance and after a period of protracted abstinence with or without daily extinction training. We also examined agonist effects on cocaine-seeking behavior at different time points during abstinence. During maintenance, CP 94,253 shifted the cocaine self-administration dose–effect function on an FR5 schedule of reinforcement to the left, whereas following 21 days of abstinence CP 94,253 downshifted the function and also decreased responding on a progressive ratio schedule of reinforcement regardless of extinction history. CP 94,253 also attenuated cue-elicited and cocaine-primed drug-seeking behavior following 5 days, but not 1 day, of forced abstinence. The attenuating effects of CP 94,253 on the descending limb of the cocaine dose–effect function were blocked by the selective 5-HT1B receptor antagonist SB 224289 (5 mg/kg, i.p.) at both time points, indicating 5-HT1B receptor mediation. The results support a switch in 5-HT1B receptor modulation of cocaine reinforcement from facilitatory during self-administration maintenance to inhibitory during protracted abstinence. These findings suggest that the 5-HT1B receptor may be a novel target for developing medication for treating cocaine dependence. PMID:24369697

  13. Pharmacological evidence for an abstinence-induced switch in 5-HT1B receptor modulation of cocaine self-administration and cocaine-seeking behavior.

    PubMed

    Pentkowski, Nathan S; Harder, Bryan G; Brunwasser, Samuel J; Bastle, Ryan M; Peartree, Natalie A; Yanamandra, Krishna; Adams, Matt D; Der-Ghazarian, Taleen; Neisewander, Janet L

    2014-03-19

    Studies examining serotonin-1B (5-HT1B) receptor manipulations on cocaine self-administration and cocaine-seeking behavior initially seemed discrepant. However, we recently suggested based on viral-mediated 5-HT1B-receptor gene transfer that the discrepancies are likely due to differences in the length of abstinence from cocaine prior to testing. To further validate our findings pharmacologically, we examined the effects of the selective 5-HT1B receptor agonist CP 94,253 (5.6 mg/kg, s.c.) on cocaine self-administration during maintenance and after a period of protracted abstinence with or without daily extinction training. We also examined agonist effects on cocaine-seeking behavior at different time points during abstinence. During maintenance, CP 94,253 shifted the cocaine self-administration dose-effect function on an FR5 schedule of reinforcement to the left, whereas following 21 days of abstinence CP 94,253 downshifted the function and also decreased responding on a progressive ratio schedule of reinforcement regardless of extinction history. CP 94,253 also attenuated cue-elicited and cocaine-primed drug-seeking behavior following 5 days, but not 1 day, of forced abstinence. The attenuating effects of CP 94,253 on the descending limb of the cocaine dose-effect function were blocked by the selective 5-HT1B receptor antagonist SB 224289 (5 mg/kg, i.p.) at both time points, indicating 5-HT1B receptor mediation. The results support a switch in 5-HT1B receptor modulation of cocaine reinforcement from facilitatory during self-administration maintenance to inhibitory during protracted abstinence. These findings suggest that the 5-HT1B receptor may be a novel target for developing medication for treating cocaine dependence. PMID:24369697

  14. Parity-violating effects in an exotic perturbation of the rigid rotator

    NASA Astrophysics Data System (ADS)

    Pallares-Rivera, A.; Kirchbach, M.

    2015-03-01

    The perturbation of the free rigid rotator by the trigonometric Scarf potential is shown to conserve its energy excitation patterns and change only the wave functions towards spherical harmonics rescaled by a function of an unspecified parity, or mixtures of such rescaled harmonics of equal magnetic quantum numbers and different angular momenta. In effect, no parity can be assigned to the states of the rotational bands emerging in this exotic way, and the electric dipole operator is allowed to acquire non-vanishing expectation values.

  15. Calculations of the neutron skin and its effect in atomic parity violation

    SciTech Connect

    Brown, B. A.; Derevianko, A.; Flambaum, V. V.

    2009-03-15

    We perform calculations for the neutron skin of nuclei and its contribution to atomic parity nonconservation (PNC) in many isotopes of Cs, Ba, Sm, Dy, Yb, Tl, Pb, Bi, Fr, and Ra. Three problems are addressed: (i) neutron-skin-induced errors to single-isotope PNC, (ii) the possibility of measuring neutron skin using atomic PNC, and (iii) neutron-skin-induced errors for ratios of PNC effects in different isotopes. In the latter case the correlations in the neutron skin values for different isotopes lead to cancellations of the errors; this makes the isotopic ratio method a competitive tool in a search for new physics beyond the standard model.

  16. Isospin symmetry violating effects and scattering length extraction from kaon decays

    SciTech Connect

    Gevorkyan, S. R.

    2013-08-15

    The isospin symmetry breaking effects in the charged kaons decays to two or three pions are considered. In semileptonic decay K{sup {+-}} {yields} {pi}{sup +}{pi}{sup -}e{sup {+-}}{nu} (called K{sub e4}) these effects turn out to be crucial for correct extraction of {pi}{pi} scattering lengths. Taking in account electromagnetic interaction between the pions in the final state and isospin symmetry breaking due to different masses of charged and neutral pions allows to adjust the values of scattering lengths obtained from experimental data on K{sub e4} decay and predictions of Chiral Perturbation Theory (ChPT). Final state interactions of pions in the decay K{sup {+-}} {yields} {pi}{sup {+-}}{pi}{sup 0}{pi}{sup 0} leading to the anomaly (cusp) in the {pi}{sup 0}{pi}{sup 0} invariant mass distribution in the vicinity of charged pions' threshold are discussed and recent results of accounting of the electromagnetic interaction among charged pions leading to {pi}{sup +}{pi}{sup -} bound states (pioniumatom) just under the charged pions' threshold are presented.

  17. Effects of final-state interactions on mixing-induced CP violation in penguin-dominated B decays

    SciTech Connect

    Cheng, H.-Y.; Chua, C.-K.; Soni, Amarjit

    2005-07-01

    Motivated by the recent indications of the possibility of sizable deviations of the mixing-induced CP violation parameter, S{sub f}, in the penguin-dominated b{yields}sqq transition decays such as B{sup 0}{yields}({phi},{omega},{rho}{sup 0},{eta}{sup '},{eta},{pi}{sup 0},f{sub 0})K{sub S} from sin2{beta} determined from B{yields}J/{psi}K{sub S}, we study final-state rescattering effects on their decay rates and CP violation. Recent observations of large direct CP asymmetry in modes such as B{sup 0}{yields}K{sup +}{pi}{sup -},{rho}{sup -}{pi}{sup +} suggest that final-state phases in two-body B decays may not be small. It is therefore important to examine these long-distance effects on penguin-dominated decays. Such long-distance effects on S{sub f} are found to be generally small [i.e. O(1-2%)] or negligible except for the {omega}K{sub S} and {rho}{sup 0}K{sub S} modes where S{sub f} is lowered by around 15% for the former and increased by the same percentage for the latter. However, final-state rescattering can enhance the {omega}K{sub S}, {phi}K{sub S}, {eta}{sup '}K{sub S}, {rho}{sup 0}K{sub S}, and {pi}{sup 0}K{sub S} rates significantly and flip the signs of direct CP asymmetries of the last two modes. Direct CP asymmetries in {omega}K{sub S} and {rho}{sup 0}K{sub S} channels are predicted to be A{sub {omega}}{sub K{sub S}}{approx_equal}-0.13 and A{sub {rho}{sup 0}}{sub K{sub S}}{approx_equal}0.47, respectively. However, direct CP asymmetry in all the other b{yields}s penguin-dominated modes that we study is found to be rather small ( < or approx. a few percent), rendering these modes a viable place to search for the CP-odd phases beyond the standard model. Since {delta}S{sub f} ({identical_to}-{eta}{sub f}S{sub f}-S{sub J/{psi}}{sub K{sub S}}, with {eta}{sub f} being the CP eigenvalue of the final state f) and A{sub f} are closely related, the theoretical uncertainties in the mixing-induced parameter S{sub f} and the direct CP asymmetry parameter A{sub f} are

  18. Adolescent Heavy Drinkers’ Amplified Brain Responses to Alcohol Cues Decrease Over One Month of Abstinence

    PubMed Central

    Brumback, Ty; Squeglia, Lindsay M.; Jacobus, Joanna; Pulido, Carmen; Tapert, Susan F.; Brown, Sandra A.

    2015-01-01

    Introduction Heavy drinking during adolescence is associated with increased reactivity to alcohol related stimuli and to differential neural development. Alcohol cue reactivity has been widely studied among adults with alcohol use disorders, but little is known about the neural substrates of cue reactivity in adolescent drinkers. The current study aimed to identify changes in blood-oxygen level dependent (BOLD) signal during a cue reactivity task pre- and post-monitored abstinence from alcohol. Method Demographically matched adolescents (16.0–18.9 years, 54% female) with histories of heavy episodic drinking (HD; n=22) and light or non-drinking control teens (CON; n=16) were recruited to participate in a month-long study. All participants completed a functional Magnetic Resonance Imaging (fMRI) scan with an alcohol cue reactivity task and substance use assessments at baseline and after 28 days of monitored abstinence from alcohol and drugs (i.e., urine toxicology testing every 48-72 hours). Repeated-measure analysis of variance (ANOVA) examined main effects of group, time, and group × time interactions on BOLD signal response in regions of interest defined by functional differences at baseline. Results The HD group exhibited greater (p<.01) BOLD activation than CON to alcohol cues relative to neutral cues in all regions of interest (ROIs; bilateral striatum/globus pallidus, left anterior cingulate, bilateral cerebellum, and parahippocampal gyrus extending to the thalamus/substantia nigra) across time points. Group × time effects showed that HD exhibited greater BOLD activation to alcohol cues than CON at baseline in left anterior cingulate cortex and in the right cerebellar region, but these decreased to non-significance after one month of monitored abstinence. Conclusions In all ROIs examined, HD exhibited greater BOLD response than CON to alcohol relative to neutral beverage picture cues at baseline, indicating heightened cue reactivity to alcohol cues in

  19. Emotion-word Processing Difficulties in Abstinent Alcoholics with and without Lifetime Externalizing Disorders

    PubMed Central

    Endres, Michael J.; Fein, George

    2015-01-01

    Background Evidence suggests that abstinent alcoholics have difficulties processing a variety of emotion-laden stimuli, and some of these difficulties may not fully resolve with long-term abstinence. The current study examined whether emotion-word processing difficulties were present in long-term abstinent alcoholics (LTAA; 18+ months of sobriety) with and without a previously diagnosed externalizing (EXT; ASPD and/or ADHD diagnosis) disorder. Method Subjects (N=121) completed an affective go/no-go (AGNG) task with positive, negative, and neutral emotion-word stimuli, and a lexical decision-making (LDM) task with non-emotion word and non-word stimuli. Non-substance abusing controls (NSAC; n=38, 50.0 % Female, mean age=48±7.8), LTAA with EXT (n=32, 41% Female, mean age=47.1±6.6 years), and LTAA without EXT (n=51, 47% Female, mean age=49.7±6.5 years) were compared on signal discriminability (d’) and mean RT for correct responses (mcRT). Results In the LDM task, LTAA had lower (d’) values and slower mcRT than NSAC. In the AGNG task, LTAA and NSAC did not differ in AGNG task mcRT. LTAA had lower (d’) values than NSAC, and this effect was partially associated with group differences in LDM task (d’) values. In LTAA, lower AGNG (d’) values also were associated with an earlier age of first drink, greater lifetime alcohol use, and a history of externalizing disorder. Conclusions Our findings suggest that detecting the emotional content of words is impaired in LTAA, and this impairment is over and above LTAA’s more general lexical processing difficulties. Results also suggest that specific emotion processing impairments in LTAA may be exacerbated by greater lifetime alcohol use burden and other comorbid EXT diagnoses. PMID:23278634

  20. Sublingual Buprenorphine for Treatment of the Neonatal Abstinence Syndrome: A Randomized Trial

    PubMed Central

    Kraft, Walter K.; Gibson, Eric; Dysart, Kevin; Damle, Vidula S.; LaRusso, Jennifer L.; Greenspan, Jay S.; Moody, David E.; Kaltenbach, Karol; Ehrlich, Michelle E.

    2008-01-01

    Objective In utero exposure to drugs of abuse can lead to the Neonatal Abstinence Syndrome (NAS), a condition that is associated with prolonged hospitalization. Buprenorphine is a partial mu opioid agonist used for treatment of adult detoxification and maintenance, but has never been administered to neonates with opioid abstinence. The primary objective of this study was to demonstrate the feasibility and to the extent possible in this sized study, the safety of sublingual buprenorphine in the treatment of NAS. Secondary goals were to evaluate efficacy relative to standard therapy and to characterize buprenorphine pharmacokinetics when sublingually administered. Methods We conducted a randomized, open-label, active control study of sublingual buprenorphine for the treatment of opiate withdrawal. Thirteen term infants were allocated to sublingual buprenorphine 13.2–39 mcg/kg/day administered in three divided doses and thirteen to standard of care oral neonatal opium solution (NOS). Dose decisions were made using a modified Finnegan scoring system. Results Sublingual buprenorphine was largely effective in controlling NAS. Greater than 98% of plasma concentrations ranged from undetectable to approximately 0.60 ng/ml, which is less than needed to control abstinence symptoms in adults. The ratio of buprenorphine to norbuprenorphine was larger than that seen in adults, suggesting a relative impairment of N-dealkylation. Three infants receiving buprenorphine and one infant receiving standard of care reached protocol-specified maximum doses and required adjuvant therapy with phenobarbital. The mean length of treatment for the NOS group was 32 compared to 22 days for the buprenorphine group. The mean length of stay for the NOS group was 38 days compared to 27 days for the buprenorphine group. Treatment with buprenorphine was well tolerated. Conclusions Buprenorphine administered via the sublingual route is feasible and apparently safe, and may represent a novel treatment

  1. Student evaluation of sex education programs advocating abstinence.

    PubMed

    Olsen, J; Weed, S; Nielsen, A; Jensen, L

    1992-01-01

    This research examined the attitudes of students who were enrolled in three different sex education programs that emphasize abstinence. Data were examined to determine whether secondary school students responded positively to the programs. The programs examined were Values and Choices, Teen Aid, and Sex Respect. Results of the study indicated that all three programs were rated positively, with female, younger (junior high school age), and virgin-naive students rating the programs more highly. PMID:1621567

  2. Internet-based group contingency management to promote smoking abstinence.

    PubMed

    Dallery, Jesse; Meredith, Steven; Jarvis, Brantley; Nuzzo, Paul A

    2015-06-01

    Internet-based group contingencies have been shown to promote brief periods of abstinence from cigarette smoking. Under a group contingency, small teams of smokers must collectively meet abstinence goals to receive monetary consequences. The present study investigated 2 arrangements, 1 in which all team members had to meet group treatment goals to receive monetary consequences (full group), and 1 in which team members had to meet some group goals and some individual goals to receive these consequences (mixed group). Mo̅tiv8 Systems, an Internet-based remote monitoring platform, was used to collect video-recorded breath carbon monoxide (CO) samples. All team members could communicate with each other via an online discussion forum. During baseline conditions, only 3.3% of CO samples were negative for smoking, which suggests that self-monitoring and access to the online discussion forum were insufficient to initiate abstinence. When the group contingencies were instituted 41.3% of CO samples were negative. There were no statistically significant differences between the 2 arrangements in the percentage of negative CO samples or point prevalence at the end of treatment or at the 3-month follow-up. Participants posted an average of 25 comments on the discussion forum, most of which were rated as positive by independent observers. The mean cost of vouchers per participant was lower in the full group ($33) relative to the mixed group ($190). The present results replicate and extend previous findings on group contingencies to promote abstinence and social support. PMID:25821915

  3. Second Law violations in the wake of the Electrocaloric Effect in liquid dielectrics

    NASA Astrophysics Data System (ADS)

    Trupp, Andreas

    2002-11-01

    In any textbook on physics, Coulomb's law of the mutual force between two point charges q0 at a distance r is modified by the appearance of the term K if the point charges are embedded in a dielectric: F = 1/4πɛ0 q0/2K r2 = 4πɛ0 K V2 The dimensionless constant K (⩾ 1) denotes the permittivity of the dielectric. According to this formula, the force is either reduced by the factor 1/K -if the charges q0 are kept invariant in amount-, or is increased by the factor K -if the potential V is kept invariant- as a result of the introduction of the dielectric. V is the potential of the location of one point charge as a result of the field generated by the other point charge. Feynman argues that the formula is correct only if the dielectric is a liquid, and that it does not work properly with solids. His criticism does not go far enough. Two simple experiments with a liquid dielectric (backed by theoretical reflections) reveal that the formula is correct only if the two point charges have opposite signs (negative and positive). If the signs are equal, the formula reads (when applied to point charges in liquid dielectrics): F = 1/4πɛ0 q0/2K2 r2 = 4πɛ0 V2 Hence the force is reduced by the factor 1/K2 if the charges (of equal sign) are kept invariant, and is left unaffected by the introduction of the dielectric if the potential V is kept invariant. With a so revised formula, cyclic processes can be performed in which the electrocaloric effect (that heats up the dielectric when the electric field is being built, and cools down the dielectric when the field is disappearing) is no longer symmetrical, leading to the conversion of ambient heat to electric work as a net result of the work cycle.

  4. Initial Abstinence Status and Contingency Management Treatment Outcomes: Does Race Matter?

    PubMed Central

    Montgomery, LaTrice; Carroll, Kathleen M.; Petry, Nancy M.

    2015-01-01

    Objective Limited research has evaluated African American substance users’ response to evidence-based treatments. This study examined the efficacy of contingency management (CM) in African American and White cocaine users. Method A secondary analysis evaluated effects of race, treatment condition, and baseline cocaine urine sample results on treatment outcomes of African American (n = 444) and White (n = 403) cocaine abusers participating in one of six randomized clinical trials comparing CM to standard care. Results African American and White patients who initiated treatment with a cocaine-negative urine sample remained in treatment for similar durations and submitted a comparable proportion of negative samples during treatment regardless of treatment type; CM was efficacious in both races in terms of engendering longer durations of abstinence in patients who began treatment abstinent. Whites who began treatment with a cocaine positive sample remained in treatment longer and submitted a higher proportion of negative samples when assigned to CM than standard care. African Americans who initiated treatment with a cocaine positive sample, however, did not remain in treatment longer with CM compared with standard care, and gains in terms of drug use outcomes were muted in nature relative to Whites. This interaction effect persisted through the 9-month follow-up period. Conclusions CM is not equally effective in reducing drug use among all subgroups, specifically African American patients who are using cocaine upon treatment entry. Future research on improving treatment outcomes in this population is needed. PMID:25798729

  5. Manifestations of CP Violation in the MSSM Higgs Sector

    SciTech Connect

    Lee, Jae Sik

    2008-11-23

    We demonstrate how CP violation manifests itself in the Higgs sector of the minimal supersymmetric extension of the Standard Model (MSSM). Starting with a brief introduction to CP violation in the MSSM and its effects on the Higgs sector, we discuss some phenomenological aspects of the Higgs sector CP violation based on the two scenarios called CPX and Trimixing.

  6. Large-Nc limit reduces the number of independent few-body parity-violating low-energy constants in pionless effective field theory

    NASA Astrophysics Data System (ADS)

    Schindler, Matthias R.; Springer, Roxanne P.; Vanasse, Jared

    2016-02-01

    The symmetries of the standard model dictate that for very low energies, where nucleon dynamics can be described in terms of a pionless effective field theory ( EFT(π / ) ) , the leading-order parity-violating nucleon-nucleon Lagrangian contains five independent unknown low-energy constants (LECs). We find that imposing the approximate symmetry of QCD that appears when the number of colors Nc becomes large reduces the number of independent LECs to two at leading order in the combined EFT(π / ) and large-Nc expansions. We also find a relation between the two isoscalar LECs in the large-Nc limit. This has important implications for the number of experiments and/or lattice calculations necessary to confirm this description of physics. In particular, we find that a future measurement of the parity-violating asymmetry in γ ⃗d →n p together with the existing result for parity-violating p ⃗p scattering would constrain all leading-order (in the combined expansion) LECs. This is a considerable improvement on the previous understanding of the system.

  7. Smoking History, Nicotine Dependence, and Changes in Craving and Mood during Short-Term Smoking Abstinence in Alcohol Dependent vs. Control Smokers

    PubMed Central

    Heffner, Jaimee L.; Mingione, Carolyn; Blom, Thomas J.; Anthenelli, Robert M.

    2010-01-01

    Objective The goal of this study was to compare lifetime cigarette smoking, severity of nicotine dependence, and subjective effects of short-term tobacco abstinence in abstinent alcohol dependent (AD) and control smokers. Method AD (n=119) and control (n=55) ever smokers were compared on tobacco use history and nicotine dependence. Negative affect and craving to smoke were examined in a subsample of currently smoking AD (N=34) and control (N=19) participants during a six-hour period of tobacco abstinence using the Profile of Mood States (POMS) and the Questionnaire on Smoking Urges-Brief (QSU-B). Results Although AD smokers did not differ from controls on heaviness of smoking, they were more likely to meet lifetime criteria for nicotine dependence. AD smokers also reported more withdrawal symptoms and were more likely to endorse withdrawal-related depressed mood during past smoking reduction or abstinence periods. During short-term abstinence, AD smokers were more likely to report high craving to smoke for negative affect relief within the first 150 minutes of tobacco abstinence, but did not differ from controls on overall craving to smoke or withdrawal-related negative affect on the POMS. Conclusions Results support previous findings that AD smokers have a greater prevalence of nicotine dependence and more severe nicotine withdrawal, with a greater propensity toward withdrawal-related depressed mood. These results, along with our novel finding that greater craving to smoke in abstaining smokers with AD is specific to negative affect-related craving, suggest that negative reinforcement may be a particularly salient factor in the maintenance of tobacco use among individuals with AD. PMID:21106299

  8. How Low Should You Go? Determining the Optimal Cutoff for Exhaled Carbon Monoxide to Confirm Smoking Abstinence When Using Cotinine as Reference

    PubMed Central

    Trent, Lindsay R.; Clark, Charles B.; Stevens, Erin N.; Lahti, Adrienne C.; Hendricks, Peter S.

    2014-01-01

    Introduction: Confirming abstinence during smoking cessation clinical trials is critical for determining treatment effectiveness. Several biological methods exist for verifying abstinence (e.g., exhaled carbon monoxide [CO], cotinine), and while cotinine provides a longer window of detection, it is not easily used in trials involving nicotine replacement therapy. The Society for Research on Nicotine and Tobacco’s Subcommittee on Biochemical Verification cite 8–10 parts per million (ppm) for CO as a viable cutoff to determine abstinence; however, recent literature suggests this cutoff is likely too high and may overestimate the efficacy of treatment. Methods: This study examined the relationship between CO and cotinine in a sample of 662 individuals participating in a smoking cessation clinical trial. A receiver operating characteristics curve was calculated to determine the percentage of false positives and false negatives at given CO levels when using cotinine as confirmation of abstinence. Differences were also examined across race and gender. Results: A CO cutoff of 3 ppm (97.1% correct classification) most accurately distinguished smokers from nonsmokers. This same cutoff was accurate for both racial and gender groups. The standard cutoffs of 8 ppm (14.0% misclassification of smokers as abstainers) and 10 ppm (20.6% misclassification of smokers as abstainers) produced very high false-negative rates and inaccurately identified a large part of the sample as being abstinent when their cotinine test identified them as still smoking. Conclusions: It is recommended that researchers and clinicians adopt a more stringent CO cutoff in the range of 3–4 ppm when complete abstinence from smoking is the goal. PMID:24891552

  9. Alterations in mesolimbic dopamine function during the abstinence period following chronic ethanol consumption.

    PubMed

    Bailey, C P; O'Callaghan, M J; Croft, A P; Manley, S J; Little, H J

    2001-12-01

    Previous work demonstrated that the locomotor stimulant actions of amphetamine, cocaine and nicotine were increased when these drugs were given during the abstinence phase after chronic ethanol consumption. These changes were seen at 6 days and at 2 months after cessation of alcohol. The present study examined neuronal alterations which might be related to these changes in behaviour. Markedly reduced spontaneous firing rates of dopaminergic cells in the ventral tegmental area (VTA) in midbrain slices were seen 6 days into the abstinence period after cessation of chronic ethanol consumption, but by 2 months the firing rates had returned to control values. Increased affinity of striatal receptors for the D1-like receptor ligand 3H-SCH23390, but no change in the receptor density, was found both at the 6 day and the 2 month intervals. The binding properties of striatal D2-like receptors, of D1-like and D2-like receptors in the frontal cerebral cortex, and the release of tritiated dopamine from slices of striatum or frontal cerebral cortex, were unchanged at 6 days and 2 months. It is suggested that the decreased neuronal firing leads to a persistent increase in sensitivity of D1-like receptors and that these changes could explain the increased effects of the other drugs of abuse. PMID:11747903

  10. Frontostriatal Circuit Dynamics Correlate with Cocaine Cue-Evoked Behavioral Arousal during Early Abstinence.

    PubMed

    Smith, Wesley C; Rosenberg, Matthew H; Claar, Leslie D; Chang, Victoria; Shah, Sagar N; Walwyn, Wendy M; Evans, Christopher J; Masmanidis, Sotiris C

    2016-01-01

    It is thought that frontostriatal circuits play an important role in mediating conditioned behavioral responses to environmental stimuli that were previously encountered during drug administration. However, the neural correlates of conditioned responses to drug-associated cues are not well understood at the level of large populations of simultaneously recorded neurons, or at the level of local field potential (LFP) synchrony in the frontostriatal network. Here we introduce a behavioral assay of conditioned arousal to cocaine cues involving pupillometry in awake head-restrained mice. After just 24 h of drug abstinence, brief exposures to olfactory stimuli previously paired with cocaine injections led to a transient dilation of the pupil, which was greater than the dilation effect to neutral cues. In contrast, there was no cue-selective change in locomotion, as measured by the rotation of a circular treadmill. The behavioral assay was combined with simultaneous recordings from dozens of electrophysiologically identified units in the medial prefrontal cortex (mPFC) and ventral striatum (VS). We found significant relationships between cocaine cue-evoked pupil dilation and the proportion of inhibited principal cells in the mPFC and VS. Additionally, LFP coherence analysis revealed a significant correlation between pupillary response and synchrony in the 25-45 Hz frequency band. Together, these results show that pupil dilation is sensitive to drug-associated cues during acute stages of abstinence, and that individual animal differences in this behavioral arousal response can be explained by two complementary measures of frontostriatal network activity. PMID:27390774

  11. Guanfacine enhances inhibitory control and attentional shifting in early abstinent cocaine-dependent individuals

    PubMed Central

    Fox, Helen; Sofuoglu, Mehmet; Sinha, Rajita

    2015-01-01

    Objectives Attenuation of adrenergic drive and cognitive enhancement, via stimulation of alpha2 pre- and post-synaptic receptors, may selectively enhance executive performance in early abstinent cocaine-dependent individuals. As these cognitive processes underpin important treatment-related behaviors, the alpha2 agonist, guanfacine HCl, may represent an effective pharmaco-therapeutic intervention. Methods Twenty-five early abstinent cocaine-dependent individuals were administered a battery of neurocognitive tasks on entry into treatment (baseline) and again following 3 weeks of either placebo or guanfacine treatment (up to 3 mg). Tasks included: Stop Signal, Stroop, 3-Dimentional Intra-dimensional/Extra-dimensional (IDED) task, Spatial Working Memory (SWM), Paired Associates Learning (PAL), Verbal Fluency and the Rey Auditory Verbal Learning Test (RAVLT). Results Compared with placebo, the guanfacine group demonstrated attenuated anxiety and negative affect as well as improved performance on selective executive tests. This included fewer directional errors on the stop signal task, fewer errors on the extra-dimensional shift component of the IDED task and better attentional switching during verbal fluency. Guanfacine did not improve strategic working memory or peripheral memory. Conclusion Guanfacine improves selective cognitive processes which may underlie salient treatment-related regulatory behaviors. Alpha2 agonists may therefore represent important agents for cocaine dependence. PMID:25567555

  12. Experiences of food abstinence in patients with type 2 diabetes: a qualitative study

    PubMed Central

    Buchmann, Maike; Wermeling, Matthias; Lucius-Hoene, Gabriele; Himmel, Wolfgang

    2016-01-01

    Objective People with type 2 diabetes often report pressure to abstain from many of life's pleasures. We tried to reconstruct these patients’ sense of pressure to better understand how people with diabetes make sense of, and integrate, these feelings into their life. Design, setting and participants A secondary analysis of narrative interviews with 14 patients with type 2 diabetes who are part of a website project. Main outcome measures Grounded theory-based analysis of narrative interviews, consisting of open, axial and selective coding. Results People with type 2 diabetes felt obliged to give up many pleasures and live a life of abstinence. They perceived a pressure to display a modest culinary lifestyle via improved laboratory test results and weight. Their verbal efforts to reassure and distance themselves from excessiveness indicate a high moral pressure. With regard to the question of how to abstain, food and behaviour were classified into healthy and unhealthy. Personal rules sometimes led to surprising experiences of freedom. Conclusions People with diabetes have internalised that their behaviour is a barrier to successful treatment. They experience an intensive pressure to show abstinence and feel misjudged when their efforts have no visible effect. Taking into account this moral pressure, and listening to patients’ personal efforts and strategies to establish healthy behaviours, might help to build a trusting relationship with healthcare providers. PMID:26739724

  13. Frontostriatal Circuit Dynamics Correlate with Cocaine Cue-Evoked Behavioral Arousal during Early Abstinence123

    PubMed Central

    Shah, Sagar N.; Evans, Christopher J.

    2016-01-01

    It is thought that frontostriatal circuits play an important role in mediating conditioned behavioral responses to environmental stimuli that were previously encountered during drug administration. However, the neural correlates of conditioned responses to drug-associated cues are not well understood at the level of large populations of simultaneously recorded neurons, or at the level of local field potential (LFP) synchrony in the frontostriatal network. Here we introduce a behavioral assay of conditioned arousal to cocaine cues involving pupillometry in awake head-restrained mice. After just 24 h of drug abstinence, brief exposures to olfactory stimuli previously paired with cocaine injections led to a transient dilation of the pupil, which was greater than the dilation effect to neutral cues. In contrast, there was no cue-selective change in locomotion, as measured by the rotation of a circular treadmill. The behavioral assay was combined with simultaneous recordings from dozens of electrophysiologically identified units in the medial prefrontal cortex (mPFC) and ventral striatum (VS). We found significant relationships between cocaine cue-evoked pupil dilation and the proportion of inhibited principal cells in the mPFC and VS. Additionally, LFP coherence analysis revealed a significant correlation between pupillary response and synchrony in the 25–45 Hz frequency band. Together, these results show that pupil dilation is sensitive to drug-associated cues during acute stages of abstinence, and that individual animal differences in this behavioral arousal response can be explained by two complementary measures of frontostriatal network activity. PMID:27390774

  14. Atomic CP-violating polarizability

    SciTech Connect

    Ravaine, Boris; Derevianko, Andrei; Kozlov, M.G.

    2005-07-15

    Searches for CP-violating effects in atoms and molecules provide important constrains on competing extensions to the standard model of elementary particles. In particular, CP violation in an atom leads to the CP-odd (T,P-odd) polarizability {beta}{sup CP}: a magnetic moment {mu}{sup CP} is induced by an electric field E{sub 0} applied to an atom, {mu}{sup CP}={beta}{sup CP}E{sub 0}. We estimate the CP-violating polarizability for rare-gas (diamagnetic) atoms He through Rn. We relate {beta}{sup CP} to the permanent electric dipole moment (EDM) of the electron and to the scalar constant of the CP-odd electron-nucleus interaction. The analysis is carried out using the third-order perturbation theory and the Dirac-Hartree-Fock formalism. We find that, as a function of nuclear charge Z, {beta}{sup CP} scales steeply as Z{sup 5}R(Z), where slowly varying R(Z) is a relativistic enhancement factor. Finally, we evaluate the feasibility of setting a limit on electron EDM by measuring CP-violating magnetization of liquid Xe. We find that such an experiment could provide competitive bounds on electron EDM only if the present level of experimental sensitivity to ultraweak magnetic fields [Kominis et al., Nature 422, 596 (2003)] is improved by several orders of magnitude.

  15. Ketamine and MAG Lipase Inhibitor-Dependent Reversal of Evolving Depressive-Like Behavior During Forced Abstinence From Alcohol Drinking.

    PubMed

    Holleran, Katherine M; Wilson, Hadley H; Fetterly, Tracy L; Bluett, Rebecca J; Centanni, Samuel W; Gilfarb, Rachel A; Rocco, Lauren E R; Patel, Sachin; Winder, Danny G

    2016-07-01

    Although alcoholism and depression are highly comorbid, treatment options that take this into account are lacking, and mouse models of alcohol (ethanol (EtOH)) intake-induced depressive-like behavior have not been well established. Recent studies utilizing contingent EtOH administration through prolonged two-bottle choice access have demonstrated depression-like behavior following EtOH abstinence in singly housed female C57BL/6J mice. In the present study, we found that depression-like behavior in the forced swim test (FST) is revealed only after a protracted (2 weeks), but not acute (24 h), abstinence period. No effect on anxiety-like behavior in the EPM was observed. Further, we found that, once established, the affective disturbance is long-lasting, as we observed significantly enhanced latencies to approach food even 35 days after ethanol withdrawal in the novelty-suppressed feeding test (NSFT). We were able to reverse affective disturbances measured in the NSFT following EtOH abstinence utilizing the N-methyl D-aspartate receptor (NMDAR) antagonist and antidepressant ketamine but not memantine, another NMDAR antagonist. Pretreatment with the monoacylglycerol (MAG) lipase inhibitor JZL-184 also reduced affective disturbances in the NSFT in ethanol withdrawn mice, and this effect was prevented by co-administration of the CB1 inverse agonist rimonabant. Endocannabinoid levels were decreased within the BLA during abstinence compared with during drinking. Finally, we demonstrate that the depressive behaviors observed do not require a sucrose fade and that this drinking paradigm may favor the development of habit-like EtOH consumption. These data could set the stage for developing novel treatment approaches for alcohol-withdrawal-induced mood and anxiety disorders. PMID:26751284

  16. Aspiring to physical health: The role of aspirations for physical health in facilitating long-term tobacco abstinence

    PubMed Central

    Niemiec, Christopher P.; Ryan, Richard M.; Deci, Edward L.; Williams, Geoffrey C.

    2009-01-01

    Objective To assess aspirations for physical health over 18 months. To examine whether maintained importance of aspirations for physical health mediated and/or moderated the effect of an intensive intervention on long-term tobacco abstinence. Methods Participants were randomly assigned to an intervention based on self-determination theory or to community care, and provided data at baseline and at 18 and 30 months post-randomization. Results Aspirations for physical health were better maintained over 18 months among participants in the intervention (mean change = .05), relative to community care (mean change = -.13), t = 2.66, p < .01. Maintained importance of aspirations for physical health partially mediated the treatment condition effects on seven-day point prevalence tobacco abstinence (z′ = 1.68, p < .01) and the longest number of days not smoking (z′ = 2.16, p < .01), and interacted with treatment condition to facilitate the longest number of days not smoking (β = .08, p < .05). Conclusion Maintained importance of aspirations for physical health facilitated tobacco abstinence. Practice implications Smokers may benefit from discussing aspirations for physical health within autonomy-supportive interventions. Patients may benefit from discussing aspirations during counseling about therapeutic lifestyle change and medication use. PMID:18838243

  17. R-parity violating effects in top quark flavor-changing neutral-current production at LHC

    SciTech Connect

    Cao Junjie; Heng Zhaoxia; Yang Jinmin; Wu Lei

    2009-03-01

    In the minimal supersymmetric model the R-parity violating top quark interactions, which are so far weakly constrained, can induce various flavor-changing neutral-current (FCNC) productions for the top quark at the large hadron collider (LHC). In this work we assume the presence of the B-violating couplings and examine their contributions to the FCNC productions proceeding through the parton processes cg{yields}t, gg{yields}tc, cg{yields}t{gamma}, cg{yields}tZ and cg{yields}th. We find that all these processes can be greatly enhanced relative to the R-parity preserving predictions. In the parameter space allowed by current experiments, all the production channels except cg{yields}th can reach the 3{sigma} sensitivity, in contrast to the R-parity preserving case in which only cg{yields}t can reach the 3{sigma} sensitivity.

  18. Violations of Management Principles within Academe.

    ERIC Educational Resources Information Center

    Sikula, Andrew F.; Sikula, John P.

    1980-01-01

    Principles of effective management commonly violated by educational institutions include: (1) unity of command; (2) division or specialization of labor; (3) delegation of authority; and (4) authority equal to responsibility. (JMF)

  19. Gender difference in hippocampal volume reduction among abstinent methamphetamine users

    PubMed Central

    Du, Jiang; Quan, Meina; Zhuang, Wenxu; Zong, Na; Jiang, Haifeng; Kennedy, David N.; Harrington, Amy; Ziedonis, Douglas; Fan, Xiaoduo; Zhao, Min

    2015-01-01

    Background and Aims Growing evidence suggests abnormalities in brain morphology including hippocampal structure in patients with methamphetamine (MA) dependence. Yet little is known about the possible gender difference. This study was performed to examine hippocampal volume in abstinent male and female MA users, and to further explore its relationship with cognitive function. Methods 27 abstinent MA users (19 males and 8 females) with average 5.75 months of duration and 29 healthy controls (19 males and 10 females) age 18 to 45 years old were recruited for clinical assessment and imaging scan. FreeSurfer was used to segment the hippocampus bilaterally, and hippocampal volumes were extracted for group and gender comparisons. Cognitive function was measured using the CogState Battery Chinese language version (CSB-C). Results Analysis of covariance (ANCOVA) controlling for education showed a significant group by gender interaction for right hippocampal relative volume adjusted for total brain size (p=0.002). Female patients showed significantly less volume compared with female healthy controls; there was no significant difference in volume between male patients and male healthy controls. Within female patients, there were significant negative relationships between right hippocampal volume and average dose of MA use (p=0.001), as well as the total error scores on the Continuous Paired Association Learning Task (CPAL) in CSB-C (p=0.013). Conclusions There seems to be a gender difference in how MA affects hippocampal volume and cognitive function in abstinent MA users. Hippocampus might be an important treatment target for cognitive improvement and functional recovery in this patient population, especially in females. PMID:25920682

  20. Dissociated Grey Matter Changes with Prolonged Addiction and Extended Abstinence in Cocaine Users

    PubMed Central

    Connolly, Colm G.; Bell, Ryan P.; Foxe, John J.; Garavan, Hugh

    2013-01-01

    Extensive evidence indicates that current and recently abstinent cocaine abusers compared to drug-naïve controls have decreased grey matter in regions such as the anterior cingulate, lateral prefrontal and insular cortex. Relatively little is known, however, about the persistence of these deficits in long-term abstinence despite the implications this has for recovery and relapse. Optimized voxel based morphometry was used to assess how local grey matter volume varies with years of drug use and length of abstinence in a cross-sectional study of cocaine users with various durations of abstinence (1–102 weeks) and years of use (0.3–24 years). Lower grey matter volume associated with years of use was observed for several regions including anterior cingulate, inferior frontal gyrus and insular cortex. Conversely, higher grey matter volumes associated with abstinence duration were seen in non-overlapping regions that included the anterior and posterior cingulate, insular, right ventral and left dorsal prefrontal cortex. Grey matter volumes in cocaine dependent individuals crossed those of drug-naïve controls after 35 weeks of abstinence, with greater than normal volumes in users with longer abstinence. The brains of abstinent users are characterized by regional grey matter volumes, which on average, exceed drug-naïve volumes in those users who have maintained abstinence for more than 35 weeks. The asymmetry between the regions showing alterations with extended years of use and prolonged abstinence suggest that recovery involves distinct neurobiological processes rather than being a reversal of disease-related changes. Specifically, the results suggest that regions critical to behavioral control may be important to prolonged, successful, abstinence. PMID:23527239

  1. Assessing White Matter Integrity as a Function of Abstinence Duration in Former Cocaine-Dependent Individuals

    PubMed Central

    Bell, Ryan P.; Foxe, John J.; Nierenberg, Jay; Hoptman, Matthew J.; Garavan, Hugh

    2010-01-01

    Current cocaine-dependent users show reductions in white matter (WM) integrity, especially in cortical regions associated with cognitive control that have been associated with inhibitory dysfunction. A key question is whether these white matter differences are present following abstinence from drug use. To address this, WM integrity was examined using diffusion tensor imaging (DTI) obtained on 43 cocaine abstinent patients (abstinence duration ranged between five days and 102 weeks) and 43 non-using controls. Additionally, a cross-sectional comparison separated the patients into three groups (short-term, mid-term and long-term) based upon duration of cocaine abstinence. The 43 cocaine abstinent patients showed lower fractional anisotropy (FA) in the left anterior callosal fibers, left genu of the corpus callosum, right superior longitudinal fasciculus, right callosal fibers and the superior corona radiata bilaterally when compared against non-using controls. Higher FA in the cocaine abstinent patients was observed in the splenium of the corpus callosum and right superior longitudinal fasciculus. Differences between the cocaine abstinent groups were observed bilaterally in the inferior longitudinal fasciculus, right anterior thalamic radiation, right ventral posterolateral nucleus of the thalamus, left superior corona radiata, superior longitudinal fasciculus bilaterally, right cingulum and the WM of the right precentral gyrus. The results identified WM differences between cocaine abstinent patients and controls as well as distinct differences between abstinent subgroups. The findings suggest that specific white matter differences persist throughout abstinence while other, spatially distinct, differences discriminate as a function of abstinence duration. These differences may, therefore, represent brain changes that mark recovery from addiction. PMID:21075564

  2. Relapse prevention and maintaining abstinence in older adults with alcohol-use disorders.

    PubMed

    Barrick, Christopher; Connors, Gerard J

    2002-01-01

    Although older adults are sometimes believed to have the lowest rates of alcohol abuse as an age cohort, the prevalence of alcohol use and abuse in this group is clearly underestimated. The under-diagnosis of alcohol abuse is due, in part, to the facts that the effects of alcohol use among older adults tend to be less clearly visible than among other age groups and that older adults are less likely to seek treatment than younger age groups. An additional challenge to diagnosis may be a lack of previous alcohol abuse by the patient, as approximately one-third of older adults with alcohol-use problems first develop their drinking problem after the age of 60 years. With a demographic shift that is expected to increase the number of older adults with alcohol problems, the awareness and understanding of this problem becomes increasingly important. Under-diagnosis of problem drinking in older adults is particularly unfortunate because the risks associated with alcohol abuse and relapse for the elderly are significant. Relapse, or the return to drinking following abstinence, may follow situations that are of particularly high risk for older adults. These include situations related to anxiety, interpersonal conflict, depression, loneliness, loss or social isolation. By helping patients to monitor these high-risk situations, to identify strategies that have been successful in promoting abstinence in the past, and to become engaged in treatment, relapse may be avoided and abstinence maintained. Treatments such as cognitive-behavioural therapy, group and family therapies and self-help groups are just as effective for older adults as they are for other age groups. In fact, group and family therapies and self-help groups may be of particular benefit to older adults because of the emphasis on social support. Medicinal adjuncts are also equally effective in the elderly, but strict compliance and careful monitoring of adverse effects are especially important in patients who take

  3. Rat nucleus accumbens core astrocytes modulate reward and the motivation to self-administer ethanol after abstinence.

    PubMed

    Bull, Cecilia; Freitas, Kelen C C; Zou, Shiping; Poland, Ryan S; Syed, Wahab A; Urban, Daniel J; Minter, Sabrina C; Shelton, Keith L; Hauser, Kurt F; Negus, S Stevens; Knapp, Pamela E; Bowers, M Scott

    2014-11-01

    Our understanding of the active role that astrocytes play in modulating neuronal function and behavior is rapidly expanding, but little is known about the role that astrocytes may play in drug-seeking behavior for commonly abused substances. Given that the nucleus accumbens is critically involved in substance abuse and motivation, we sought to determine whether nucleus accumbens astrocytes influence the motivation to self-administer ethanol following abstinence. We found that the packing density of astrocytes that were expressing glial fibrillary acidic protein increased in the nucleus accumbens core (NAcore) during abstinence from EtOH self-administration. No change was observed in the nucleus accumbens shell. This increased NAcore astrocyte density positively correlated with the motivation for ethanol. Astrocytes can communicate with one another and influence neuronal activity through gap-junction hemichannels. Because of this, the effect of blocking gap-junction hemichannels on the motivation for ethanol was examined. The motivation to self-administer ethanol after 3 weeks abstinence was increased following microinjection of gap-junction hemichannel blockers into the NAcore at doses that block both neuronal and astrocytic channels. In contrast, no effect was observed following microinjection of doses that are not thought to block astrocytic channels or following microinjection of either dose into the nucleus accumbens shell. Additionally, the motivation for sucrose after 3 weeks abstinence was unaffected by NAcore gap-junction hemichannel blockers. Next, Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) were selectively expressed in NAcore astrocytes to test the effect of astrocyte stimulation. DREADD activation increased cytosolic calcium in primary astrocytes, facilitated responding for rewarding brain stimulation, and reduced the motivation for ethanol after 3 weeks abstinence. This is the first work to modulate drug-seeking behavior with

  4. Rat Nucleus Accumbens Core Astrocytes Modulate Reward and the Motivation to Self-Administer Ethanol after Abstinence

    PubMed Central

    Bull, Cecilia; Freitas, Kelen CC; Zou, Shiping; Poland, Ryan S; Syed, Wahab A; Urban, Daniel J; Minter, Sabrina C; Shelton, Keith L; Hauser, Kurt F; Negus, S Stevens; Knapp, Pamela E; Bowers, M Scott

    2014-01-01

    Our understanding of the active role that astrocytes play in modulating neuronal function and behavior is rapidly expanding, but little is known about the role that astrocytes may play in drug-seeking behavior for commonly abused substances. Given that the nucleus accumbens is critically involved in substance abuse and motivation, we sought to determine whether nucleus accumbens astrocytes influence the motivation to self-administer ethanol following abstinence. We found that the packing density of astrocytes that were expressing glial fibrillary acidic protein increased in the nucleus accumbens core (NAcore) during abstinence from EtOH self-administration. No change was observed in the nucleus accumbens shell. This increased NAcore astrocyte density positively correlated with the motivation for ethanol. Astrocytes can communicate with one another and influence neuronal activity through gap-junction hemichannels. Because of this, the effect of blocking gap-junction hemichannels on the motivation for ethanol was examined. The motivation to self-administer ethanol after 3 weeks abstinence was increased following microinjection of gap-junction hemichannel blockers into the NAcore at doses that block both neuronal and astrocytic channels. In contrast, no effect was observed following microinjection of doses that are not thought to block astrocytic channels or following microinjection of either dose into the nucleus accumbens shell. Additionally, the motivation for sucrose after 3 weeks abstinence was unaffected by NAcore gap-junction hemichannel blockers. Next, Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) were selectively expressed in NAcore astrocytes to test the effect of astrocyte stimulation. DREADD activation increased cytosolic calcium in primary astrocytes, facilitated responding for rewarding brain stimulation, and reduced the motivation for ethanol after 3 weeks abstinence. This is the first work to modulate drug-seeking behavior with

  5. Cue reactivity in active pathological, abstinent pathological, and regular gamblers.

    PubMed

    Sodano, Ruthlyn; Wulfert, Edelgard

    2010-03-01

    Twenty-one treatment-seeking pathological gamblers, 21 pathological gamblers in recovery, and 21 recreational gamblers watched two video-taped exciting gambling scenarios and an exciting roller-coaster control scenario while their arousal (heart rate and subjective excitement) and urge to gamble were being measured. The gamblers did not differ significantly in cue-elicited heart rate elevations or excitement. However, the active pathological gamblers reported significantly greater urges to gamble across all cues compared to the abstinent pathological gamblers and, with marginal significance (p = 0.06), also compared to the social gamblers. Further exploration of these findings revealed that active pathological gamblers experience urges to gamble in response to exciting situations, whether or not they are gambling related, whereas abstinent and social gamblers only report urges to an exciting gambling-related cue. This suggests that for pathological gamblers excitement itself, irrespective of its source, may become a conditioned stimulus capable of triggering gambling behavior. Implications for treatment and future research are discussed. PMID:19662519

  6. Attitudes toward Sexual Abstinence among Black Seventh-Day Adventist College Students

    ERIC Educational Resources Information Center

    Ashley, George; Ramirez, Octavio; Cort, Malcolm

    2013-01-01

    The purpose of this study was to identify Black Seventh-Day Adventist (SDA) college students' attitudes toward the concept of sexual abstinence. Attitude toward abstinence was operationalized as a dichotomy of acceptance or rejection of the concept as a way to order sexual behavior. The study utilized a convenience sample ("N" =…

  7. Abstinence, Sex, and Virginity: Do They Mean What We Think They Mean?

    ERIC Educational Resources Information Center

    Hans, Jason D.; Kimberly, Claire

    2011-01-01

    Ambiguous definitions concerning which behaviors constitute sex, abstinence, and virginity may lead to arbitrary interpretations of meaning or miscommunication, which could be particularly problematic in health care, educational, and research contexts. The purpose of this study was to examine and compare definitions of sex, abstinence, and…

  8. Influence of Materials on Teacher Adoption of Abstinence-Only-Until-Marriage Programs

    ERIC Educational Resources Information Center

    Wilson, Kelly L.; Wiley, David C.

    2009-01-01

    Background: Given the growing scientific evidence against abstinence-only-until-marriage education, health educators are supporting an evidence-based approach to teaching sexuality education. However, there is still an abundance of federal support and funding streams allocated to sustain abstinence-only programs. This study assessed indicators…

  9. 77 FR 42768 - Leadership Meeting on Maternal, Fetal, and Infant Opioid Exposure and Neonatal Abstinence Syndrome

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-20

    ... CONTROL POLICY Leadership Meeting on Maternal, Fetal, and Infant Opioid Exposure and Neonatal Abstinence... Meeting on Maternal, Fetal and Infant Opioid Exposure and Neonatal Abstinence Syndrome (NAS) will bring together leaders in the field of policy, opioid exposed infants, pain treatment during pregnancy,...

  10. A Review of 21 Curricula for Abstinence-Only-until-Marriage Programs.

    ERIC Educational Resources Information Center

    Wilson, Kelly L.; Goodson, Patricia; Pruitt, B.E.; Buhi, Eric; Davis-Gunnels, Emily

    2005-01-01

    The authors reviewed the content, methods, and overall quality of 21 curricula used in abstinence-only-until-marriage programs. Only materials designed for use in middle school grades (fifth to eighth) or with middle school-aged audiences (9-13 years of age), which presented the abstinence message in at least 40% of their content, were included. A…

  11. Emotional reactivity to emotional and smoking cues during smoking abstinence: Potentiated startle and P300 suppression

    PubMed Central

    Engelmann, Jeffrey M.; Gewirtz, Jonathan C.; Cuthbert, Bruce N.

    2012-01-01

    Negative affect is thought to be an important factor in the maintenance of cigarette smoking, and thus it is important to further develop objective measures of smoking-related emotional responses. Nonsmokers, nonabstinent smokers, and abstinent smokers participated in a cue reactivity task where eyeblink startle amplitude and startle probe P300 (P3) suppression were measured during the presentation of emotional pictures. During unpleasant pictures, the amplitude of both measures was smaller in nonabstinent smokers than in nonsmokers or abstinent smokers. P3 suppression, but not startle amplitude, was larger in abstinent smokers than in nonsmokers. Abstinence-induced increases in cigarette craving were associated with P3 suppression during tobacco-related pictures. Results suggest that tobacco abstinence increases emotional reactivity to unpleasant stimuli, which is consistent with negative reinforcement models of tobacco addiction. PMID:24015407

  12. The Relationship of Self-Control and Abstinence Maintenance: An Exploratory Analysis of Self-Regulation

    PubMed Central

    Ferrari, Joseph R.; Stevens, Edward B.; Jason, Leonard A.

    2010-01-01

    Studies of self-regulation suggested that self-control requires finite resources which, in turn, may present a significant challenge for those trying to recover from or control addictive behaviors. The present study examined the relationships between self-regulation and abstinence maintenance among adults in recovery (n = 606: 407 men, 199 women; M age = 38.5 years) residing in self-governed, communal living, abstinent homes across the United States. Self-regulation scores (controlling for sex and age) were positively related to length of abstinence. In addition, a factor analysis of self-regulation scores resulted in some differentiation between general self-discipline and impulsivity in self-control related to addiction. The relationship between impulsivity and length of abstinence was stronger than the relationship derived between general self-regulation and length of abstinence. PMID:20689650

  13. Using incentives to encourage smoking abstinence among pregnant indigenous women? A feasibility study.

    PubMed

    Glover, Marewa; Kira, Anette; Walker, Natalie; Bauld, Linda

    2015-06-01

    Smoking during pregnancy increases the risk of many adverse health outcomes for both the mother and the unborn child (Morton et al. 2010). Indigenous people often have a higher smoking prevalence during pregnancy than non-Indigenous populations. In New Zealand (NZ), the smoking rates among Indigenous Māori women who are pregnant have reduced since 1991 (68 %) but still remains high in 2007 (34 %) (Morton et al. 2010). The success rate of most smoking cessation interventions for pregnant smokers is low at <6 % (Lumley et al. 2009). In other populations of pregnant women, financial incentives have been shown to increase the attractiveness of smoking cessation programs and increase the number of quit attempts. A feasibility study was undertaken to determine the likely effectiveness of an incentives-based cessation trial among pregnant Māori women that smoked. Pregnant smokers, aged 16 years and older, who self-identified as Māori, were 2-30 weeks pregnant, and currently smoked, were recruited through health practitioners, print media, and radio adverts in Auckland, NZ. Participants were randomised to (1) usual cessation support, including information about different cessation products and services, and access to nicotine replacement therapy (control), (2) usual cessation support plus a retail voucher to the value of NZ$25 for each 'abstinent from smoking' week for 8 weeks (voucher), or (3) usual cessation support plus product to the value of NZ$25 for each 'abstinent from smoking' week for 8 weeks (product). Outcomes measures included weekly self-reported and monthly biochemically verified smoking status, and acceptability. Of the 74 referred women, 50 declined involvement in the study and 24 consented and were randomised (eight control, eight voucher and eight to product). The mean age of participants was 25 years old (±2.25). Overall 21 % (n = 5) of the women were abstinent from smoking for at least 6 weeks of the eight, one from the control, six from the

  14. Gravity from spontaneous Lorentz violation

    SciTech Connect

    Kostelecky, V. Alan; Potting, Robertus

    2009-03-15

    We investigate a class of theories involving a symmetric two-tensor field in Minkowski spacetime with a potential triggering spontaneous violation of Lorentz symmetry. The resulting massless Nambu-Goldstone modes are shown to obey the linearized Einstein equations in a fixed gauge. Imposing self-consistent coupling to the energy-momentum tensor constrains the potential for the Lorentz violation. The nonlinear theory generated from the self-consistent bootstrap is an alternative theory of gravity, containing kinetic and potential terms along with a matter coupling. At energies small compared to the Planck scale, the theory contains general relativity, with the Riemann-spacetime metric constructed as a combination of the two-tensor field and the Minkowski metric. At high energies, the structure of the theory is qualitatively different from general relativity. Observable effects can arise in suitable gravitational experiments.

  15. Neutrino constraints on spontaneous Lorentz violation

    SciTech Connect

    Grossman, Yuval; Kilic, Can; Thaler, Jesse; Walker, Devin G.E.

    2005-12-15

    We study the effect of spontaneous Lorentz violation on neutrinos. We consider two kinds of effects: static effects, where the neutrino acquires a Lorentz-violating dispersion relation, and dynamic effects, which arise from the interactions of the neutrino with the Goldstone boson of spontaneous Lorentz violation. Static effects are well detailed in the literature. Here, special emphasis is given to the novel dynamic effect of Goldstone-Cerenkov radiation, where neutrinos moving with respect to a preferred rest frame can spontaneously emit Goldstone bosons. We calculate the observable consequences of this process and use them to derive experimental bounds from SN1987A and the CMBR. The bounds derived from dynamic effects are complementary to - and in many cases much stronger than - those obtained from static effects.

  16. A Randomized Trial of Long-Term Reinforcement of Cocaine Abstinence in Methadone-Maintained Patients Who Inject Drugs

    ERIC Educational Resources Information Center

    Silverman, Kenneth; Robles, Elias; Mudric, Timothy; Bigelow, George E.; Stitzer, Maxine L.

    2004-01-01

    This study determined whether long-term abstinence reinforcement could maintain cocaine abstinence throughout a yearlong period. Patients who injected drugs and used cocaine during methadone treatment (n = 78) were randomly assigned to 1 of 2 abstinence-reinforcement groups or to a usual care control group. Participants in the 2…

  17. Hope and Abstinence Self-Efficacy: Positive Predictors of Negative Affect in Substance Abuse Recovery

    PubMed Central

    May, Emily M.; Hunter, Bronwyn A.; Ferrari, Joseph; Noel, Nicole

    2015-01-01

    Goal-oriented thinking, including hope and self-efficacy, might play a constructive and integral role in the substance abuse recovery process, although such an effect may differ by race. The current study investigated hope and self-efficacy, specifically abstinence self-efficacy, as predictors of negative affect (i.e. depression and anxiety) in a longitudinal sample of men and women in substance abuse recovery who lived in sober living homes. We found hope agency and self-efficacy were related but not identical constructs; hope agency and self-efficacy predicted depressive and anxiety symptoms for individuals in recovery, yet these relationships were moderated by race. Theoretical and clinical implications for promoting positive affect among individuals in substance abuse recovery are discussed. PMID:25990539

  18. When the social discourse on violation behaviours is challenged by the perception of everyday life experiences: Effects of non-accident experiences on offending attitudes and habits.

    PubMed

    Lheureux, Florent; Auzoult, Laurent

    2016-09-01

    The aim of this article is to introduce the concept of the Non-Accident Experience (NAE) with regard to violations of traffic safety regulations. An NAE refers to the fact of not having been involved in an accident following the adoption of a behaviour socially recognised as promoting its occurrence. We hypothesise that this type of experiences has a strong effect on attitudes (valence and strength) and habits with regard to traffic offences such as speeding and drink-drive. An empirical study was conducted to test the relevance of this set of hypotheses. 543 French drivers participated to a survey designed to measure all these theoretical constructs. As expected, the results showed that the more frequently NAEs were experienced the more individuals had a favourable and weak (less certain, less important, more ambivalent) attitude towards violations, as well as strong habits. In addition, the more numerous NAEs experienced by others were perceived to be, the more ambivalent was the attitude. The discussion firstly concerns the methodological limitations of this study (e.g. use of cross-sectional design) as well as the integration of this concept into current research, especially in relation to the attitude strength concept and the theory of planned behaviour. Then, we discuss its practical implications (use of the experience based analysis technique, with consideration of both accident and non-accident experiences). PMID:27269997

  19. Analytical approximations for matter effects on CP violation in the accelerator-based neutrino oscillations with E ≲ 1 GeV

    NASA Astrophysics Data System (ADS)

    Xing, Zhi-zhong; Zhu, Jing-yu

    2016-07-01

    Given an accelerator-based neutrino experiment with the beam energy E ≲ 1 GeV, we expand the probabilities of ν μ → ν e and {overline{ν}}_{μ}to {overline{ν}}_e oscillations in matter in terms of two small quantities Δ21 /Δ31 and A/Δ31, where Δ 21≡ m 2 2 - m 1 2 and Δ 31≡ m 3 2 - m 1 2 are the neutrino mass-squared differences, and A measures the strength of terrestrial matter effects. Our analytical approximations are numerically more accurate than those made by Freund in this energy region, and thus they are particularly applicable for the study of leptonic CP violation in the low-energy MOMENT, ESS νSM and T2K oscillation experiments. As a by-product, the new analytical approximations help us to easily understand why the matter-corrected Jarlskog parameter tilde{J} peaks at the resonance energy E ∗ ≃ 0 .14GeV (or 0 .12 GeV) for the normal (or inverted) neutrino mass hierarchy, and how the three Dirac unitarity triangles are deformed due to the terrestrial matter contamination. We also affirm that a medium-baseline neutrino oscillation experiment with the beam energy E lying in the E ∗ ≲ E ≲ 2 E ∗ range is capable of exploring leptonic CP violation with little matter-induced suppression.

  20. Violation of the Taylor hypothesis at electron scales in the solar wind and its effects on the energy spectra measured onboard spacecraft

    NASA Astrophysics Data System (ADS)

    Huang, S.; Sahraoui, F.

    2014-12-01

    The solar wind is a natural laboratory for the study of turbulent plasma. In-situ observations from different spacecraft such as STEREO, Wind, ACE or Cluster allow us to investigate turbulence from magnetohydrodynamic (MHD) to kinetic scales (sub-ion and electron scales) of solar wind turbulence. With single spacecraft observations the Taylor frozen-in-flow assumption (Vf<violates the Taylor hypothesis. Furthermore, we introduce a toy model to investigate the effects of violating of the Taylor hypothesis on the slopes of the turbulent spectra. From different possible propagation angles and solar wind speeds we show that the slopes vary only slightly in the inertial range, while they vary significantly in the dispersive range. These simulations results can explain the narrow (resp. broader) distribution of the slopes in the inertial (resp. dispersive) range observed in the solar wind.

  1. Emotional intelligence, risk perception in abstinent cocaine dependent individuals.

    PubMed

    Romero-Ayuso, Dulce; Mayoral-Gontán, Yolanda; Triviño-Juárez, José-Matías

    2016-01-01

    Cocaine is now responsible for the second-highest number of cessation intervention requests. In this study we analyze the different skills of emotional intelligence in cocaine- dependent patients maintaining abstinence. The Mayer- Salovey-Caruso Emotional Intelligence Test (MSCEIT) and the Balloon Analogue Risk Task (BART) were administered to 50 subjects (25 individuals with no history of drug use and 25 individuals in treatment at the Addictive Behaviors Unit in a state of withdrawal at the time of evaluation). The results showed differences between these groups in overall emotional intelligence quotient, strategic emotional intelligence, understanding emotions and emotional management. Cocaine-addicted participants showed difficulties in analyzing complex emotions and regulating their emotional response, aspects that can interfere with interactions in daily life. PMID:27099213

  2. Attributes that Differentiate Children Who Sip Alcohol from Abstinent Peers

    PubMed Central

    Jackson, Christine; Ennett, Susan T.; Dickinson, Denise M.; Bowling, J. Michael

    2012-01-01

    Sipping alcohol during childhood may be a marker of differentiation as regards children’s future risk of underage drinking; yet very little is known about alcohol use when it occurs among elementary school-aged children. The purpose of the present study is to examine alcohol sipping behavior in a sample of third-grade school children to learn whether sipping is associated with attributes that could increase children’s likelihood of further underage drinking. We collected telephone interview data from 1050 mothers and their third grade children (mean age 9.2 years; 48.2% male) residing in the Southeastern United States. The majority of mothers were White non-Hispanic (69.02%) or Black non-Hispanic (21.3%); most (85%) lived in households shared with fathers or other adult caretakers. We hypothesized that children who sip alcohol would score lower than abstinent peers on indicators of competence and score higher on indicators of exposure to alcohol-specific socialization by parents and peers. A multivariate model controlling for frequency of parent alcohol use and demographic covariates showed that children who had sipped alcohol were significantly less likely than abstinent peers to affirm indicators of competence and significantly more likely to affirm indicators of exposure to alcohol specific socialization by parents and by same age peers. These preliminary findings suggest that developmental attributes associated with risk of underage drinking begin to differentiate at least as young as middle childhood. Research is needed to test prospectively for continuity between alcohol risk attributes present in middle childhood and future alcohol use. PMID:23224982

  3. A qualitative study of methamphetamine users' perspectives on barriers and facilitators of drug abstinence.

    PubMed

    Herbeck, Diane M; Brecht, Mary-Lynn; Christou, Dayna; Lovinger, Katherine

    2014-01-01

    To better understand methamphetamine (MA) use patterns and the process of recovery, qualitative interviews were conducted with adult MA users (n = 20), comparing a sample that received substance abuse treatment with those who had not received treatment. Respondents provided detailed information on why and how they changed from use to abstinence and factors they considered to be barriers to abstinence. Audio recordings and transcripts were reviewed for common themes. Participants reported a range of mild/moderate to intensely destructive problems, including loss of important relationships and profound changes to who they felt they were at their core; e.g., "I didn't realize how dark and mean I was … I was like a different person." Initial abstinence was often facilitated by multiple external forces (e.g., drug testing, child custody issues, prison, relocation), but sustained abstinence was attributed to shifts in thinking and salient realizations about using. The treatment group reported using more and different resources to maintain their abstinence than the no-treatment group. Findings indicate individualized interventions and multiple, simultaneous approaches and resources were essential in reaching stable abstinence. Understanding long-term users' experiences with MA use, addiction, and abstinence can inform strategies for engaging and sustaining MA users in treatment and recovery. PMID:25052880

  4. 10 CFR 820.25 - Final notice of violation.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... violation, any designated penalty, and further actions necessary by or available to respondent. (b) Effect.... (c) Effect of waiver. If a respondent waives further proceedings, the Final Notice of Violation shall... additional time. (d) Effect of request. If a respondent files a request for an on-the-record...

  5. Motivated Attention to Cocaine and Emotional Cues in Abstinent and Current Cocaine Users: An ERP Study

    PubMed Central

    Dunning, Jonathan P.; Parvaz, Muhammad A.; Hajcak, Greg; Maloney, Thomas; Alia-Klein, Nelly; Woicik, Patricia A.; Telang, Frank; Wang, Gene-Jack; Volkow, Nora D.; Goldstein, Rita Z.

    2011-01-01

    Event-related potentials (ERPs) are a direct measure of neural activity and are ideally suited to study the time-course of attentional engagement with emotional and drug-related stimuli in addiction. In particular, the late positive potential (LPP) appears enhanced following cocaine-related compared to neutral stimuli in individuals with cocaine use disorders (CUD). However, previous studies have not directly compared cocaine-related to emotional stimuli while examining potential differences between abstinent and current cocaine users. The present study examined ERPs in 55 CUD (27 abstinent and 28 current users) and 29 matched healthy controls while they passively viewed pleasant, unpleasant, neutral, and cocaine-related pictures. To examine the time-course of attention to these stimuli, we analyzed both an early and later window in the LPP as well as the early posterior negativity (EPN), established in assessing motivated attention. Cocaine pictures elicited increased electrocortical measures of motivated attention in ways similar to affectively pleasant and unpleasant pictures in all CUD, an effect that was no longer discernible during the late LPP window for the current users. This group also exhibited deficient processing of the other emotional stimuli (early LPP window: pleasant pictures; late LPP window: pleasant and unpleasant pictures). Results were unique to the LPP and not EPN. Taken together, results support a relatively early attention bias to cocaine stimuli in cocaine addicted individuals further suggesting that recent cocaine use decreases such attention bias during later stages of processing but at the expense of deficient processing of other emotional stimuli. PMID:21450043

  6. Environmental living conditions introduced during forced abstinence alter cocaine-seeking behavior and Fos protein expression

    PubMed Central

    Thiel, Kenneth J.; Pentkowski, Nathan S.; Peartree, Natalie A.; Painter, Michael R.; Neisewander, Janet L.

    2010-01-01

    Environmental enrichment (EE) introduced during abstinence from cocaine self-administration is protective in reducing cue-elicited incentive motivation for cocaine in rats. This study examined neural activation associated with this protective effect of EE using Fos protein expression as a marker. Rats were trained to press a lever reinforced by cocaine (0.75 mg/kg/0.1 ml infusion) and light and tone cues across 15 consecutive days during which they were all housed in isolated conditions (IC). Rats were then assigned to either remain in IC, or to live in pair-housed conditions (PC) or EE for 30 days of forced abstinence from cocaine. Subsequently, cocaine-seeking behavior (lever presses without cocaine reinforcement) elicited by response-contingent cue presentations was assessed for 90 min, after which the rats' brains were immediately harvested for Fos protein immunohistochemistry. EE attenuated, whereas IC enhanced, cue-elicited cocaine-seeking behavior relative to PC. Also, within the prelimbic and orbitofrontal cortices and basolateral amygdala, IC enhanced, whereas EE reduced, Fos expression relative to PC. Furthermore, EE attenuated Fos expression in the infralimbic and anterior cingulate cortices, the nucleus accumbens (core and shell), bed nucleus of the stria terminalis, and ventral tegmental area, evident as a reduction relative to both PC and IC. In contrast, IC enhanced Fos expression in the dorsal caudate putamen, substantia nigra, and central amygdala, evident as an increase relative to both PC and EE. These results suggest that EE blunts neural activation throughout the mesocorticolimbic circuitry involved in cue-elicited incentive motivation for cocaine, whereas IC enhances activation primarily within the nigrostriatal dopamine pathway. These findings have important implications for understanding and treating drug-conditioned craving in humans. PMID:20933585

  7. Environmental living conditions introduced during forced abstinence alter cocaine-seeking behavior and Fos protein expression.

    PubMed

    Thiel, K J; Pentkowski, N S; Peartree, N A; Painter, M R; Neisewander, J L

    2010-12-29

    Environmental enrichment (EE) introduced during abstinence from cocaine self-administration is protective in reducing cue-elicited incentive motivation for cocaine in rats. This study examined neural activation associated with this protective effect of EE using Fos protein expression as a marker. Rats were trained to press a lever reinforced by cocaine (0.75 mg/kg/0.1 mL infusion) and light and tone cues across 15 consecutive days during which they were all housed in isolated conditions (IC). Rats were then assigned to either remain in IC, or to live in pair-housed conditions (PC) or EE for 30 days of forced abstinence from cocaine. Subsequently, cocaine-seeking behavior (lever presses without cocaine reinforcement) elicited by response-contingent cue presentations was assessed for 90 min, after which the rats' brains were immediately harvested for Fos protein immunohistochemistry. EE attenuated, whereas IC enhanced, cue-elicited cocaine-seeking behavior relative to PC. Also, within the prelimbic and orbitofrontal cortices and basolateral amygdala, IC enhanced, whereas EE reduced, Fos expression relative to PC. Furthermore, EE attenuated Fos expression in the infralimbic and anterior cingulate cortices, the nucleus accumbens (core and shell), bed nucleus of the stria terminalis, and ventral tegmental area, evident as a reduction relative to both PC and IC. In contrast, IC enhanced Fos expression in the dorsal caudate putamen, substantia nigra, and central amygdala, evident as an increase relative to both PC and EE. These results suggest that EE blunts neural activation throughout the mesocorticolimbic circuitry involved in cue-elicited incentive motivation for cocaine, whereas IC enhances activation primarily within the nigrostriatal dopamine pathway. These findings have important implications for understanding and treating drug-conditioned craving in humans. PMID:20933585

  8. Genetic markers associated with abstinence length in alcohol-dependent subjects treated with acamprosate.

    PubMed

    Karpyak, V M; Biernacka, J M; Geske, J R; Jenkins, G D; Cunningham, J M; Rüegg, J; Kononenko, O; Leontovich, A A; Abulseoud, O A; Hall-Flavin, D K; Loukianova, L L; Schneekloth, T D; Skime, M K; Frank, J; Nöthen, M M; Rietschel, M; Kiefer, F; Mann, K F; Weinshilboum, R M; Frye, M A; Choi, D S

    2014-01-01

    Acamprosate supports abstinence in some alcohol-dependent subjects, yet predictors of response are unknown. To identify response biomarkers, we investigated associations of abstinence length with polymorphisms in candidate genes in glycine and glutamate neurotransmission pathways and genes previously implicated in acamprosate response. Association analyses were conducted in the discovery sample of 225 alcohol-dependent subjects treated with acamprosate for 3 months in community-based treatment programs in the United States. Data from 110 alcohol-dependent males treated with acamprosate in the study PREDICT were used for replication of the top association findings. Statistical models were adjusted for relevant covariates, including recruitment site and baseline clinical variables associated with response. In the discovery sample, shorter abstinence was associated with increased intensity of alcohol craving and lower number of days between the last drink and initiation of acamprosate treatment. After adjustment for covariates, length of abstinence was associated with the GRIN2B rs2058878 (P=4.6 × 10(-5)). In the replication sample, shorter abstinence was associated with increased craving, increased depressive mood score and higher alcohol consumption. Association of abstinence length with GRIN2B rs2058878 was marginally significant (P=0.0675); as in the discovery sample, the minor A allele was associated with longer abstinence. Furthermore, rs2300272, which is in strong linkage disequilibrium with rs2058878, was also associated with abstinence length (P=0.049). This is the first report of a replicated association of genetic markers with the length of abstinence in acamprosate-treated alcoholics. Investigation of the underlying mechanisms of this association and its usefulness for individualized treatment selection should follow. PMID:25290263

  9. Dopamine D3 and 5-HT1B receptor dysregulation as a result of psychostimulant intake and forced abstinence: Implications for medications development.

    PubMed

    Neisewander, Janet L; Cheung, Timothy H C; Pentkowski, Nathan S

    2014-01-01

    Addiction to psychostimulants, including cocaine and amphetamine, is associated with dysregulation of dopamine and serotonin (5-HT) neurotransmitter systems. Neuroadaptations in these systems vary depending on the stage of the drug taking-abstinence-relapse cycle. Consequently, the effects of potential treatments that target these systems may vary depending on whether they are given during abstinence or relapse. In this review, we discuss evidence that dopamine D3 receptors (D3Rs) and 5-HT1B receptors (5-HT1BRs) are dysregulated in response to both chronic psychostimulant use and subsequent abstinence. We then review findings from preclinical self-administration models which support targeting D3Rs and 5-HT1BRs as potential medications for psychostimulant dependence. Potential side effects of the treatments are discussed and attention is given to studies reporting positive treatment outcomes that depend on: 1) whether testing occurs during self-administration versus abstinence, 2) whether escalation of drug self-administration has occurred, 3) whether the treatments are given repeatedly, and 4) whether social factors influence treatment outcomes. We conclude that D3/D2 agonists may decrease psychostimulant intake; however, side effects of D3/D2R full agonists may limit their therapeutic potential, whereas D3/D2R partial agonists have fewer undesirable side effects. D3-selective antagonists may not reduce psychostimulant intake during relapse, but nonetheless, may decrease motivation for seeking psychostimulants with relatively few side-effects. 5-HT1BR agonists provide a striking example of treatment outcomes that are dependent on the stage of the addiction cycle. Specifically, these agonists initially increase cocaine's reinforcing effects during maintenance of self-administration, but after a period of abstinence they reduce psychostimulant seeking and the resumption of self-administration. In conclusion, we suggest that factors contributing to dysregulation of

  10. The Effects of Violation of Data Set Assumptions when Using the Oneway, Fixed Effects Analysis of Variance and the One Concomitant Analysis of Covariance Statistical Procedures.

    ERIC Educational Resources Information Center

    Johnson, Colleen Cook

    The purpose of this study is to help define the precise nature and limits of the tolerable range in which a researcher may be relatively confident about the statistical validity of his or her research findings, focusing specifically on the statistical validity of results when violating the assumptions associated with the one-way, fixed-effects…

  11. CP violation in K decays

    SciTech Connect

    Gilman, F.J.

    1989-05-01

    Recent theoretical and experimental progress on the manifestation of CP violation in K decays, and toward understanding whether CP violation originates in a phase, or phases, in the weak mixing matrix of quarks is reviewed. 23 refs., 10 figs.

  12. Violations of Temporary Flight Restrictions and Air Defense Identification Zones: An Analysis of Airspace Violations and Pilot Report Data

    NASA Technical Reports Server (NTRS)

    Zuschlag, Michael

    2005-01-01

    This document provides the results from a study into the apparent factors and causes of violations of restricted airspace, particularly temporary flight restrictions (TFRs) and air defense identification zones (ADIZs). By illuminating the reasons for these violations, this study aims to take the first step towards reducing them. The study assesses the basic characteristics of restricted airspace violations as well as the probable causes and factors contributing to violations. Results from the study imply most violations occur where the restriction has been in place for a significant amount of time prior to the violation. Additionally, the study results imply most violations are not due to the pilot simply being unaware of the airspace at the time of violation. In most violations, pilots are aware of the presence of the restricted airspace but have incorrect information about it, namely, its exact boundaries or procedures for authorized penetration. These results imply that the best means to reduce violations of restricted airspace is to improve the effectiveness of providing pilots the details required to avoid the airspace.

  13. Resolving Standard and Nonstandard CP Violation Phases in Neutrino Oscillations

    SciTech Connect

    Gago, A. M.; Minakata, H.; Uchinami, S.; Nunokawa, H.; Zukanovich Funchal, R.

    2010-03-30

    Neutrino oscillations can exhibit extra CP violation effects, beyond those expected from the standard Kobayashi-Maskawa phase delta, if non-standard neutrino interactions are at play. We show that it is possible to disentangle the two CP violating effects by measuring muon neutrino appearance using a near-far two detector setting in a neutrino factory experiment.

  14. Temperature dependence of standard model CP violation.

    PubMed

    Brauner, Tomáš; Taanila, Olli; Tranberg, Anders; Vuorinen, Aleksi

    2012-01-27

    We analyze the temperature dependence of CP violation effects in the standard model by determining the effective action of its bosonic fields, obtained after integrating out the fermions from the theory and performing a covariant gradient expansion. We find nonvanishing CP violating terms starting at the sixth order of the expansion, albeit only in the C-odd-P-even sector, with coefficients that depend on quark masses, Cabibbo-Kobayashi-Maskawa matrix elements, temperature and the magnitude of the Higgs field. The CP violating effects are observed to decrease rapidly with temperature, which has important implications for the generation of a matter-antimatter asymmetry in the early Universe. Our results suggest that the cold electroweak baryogenesis scenario may be viable within the standard model, provided the electroweak transition temperature is at most of order 1 GeV. PMID:22400822

  15. Incentive Learning for Morphine-Associated Stimuli During Protracted Abstinence Increases Conditioned Drug Preference

    PubMed Central

    Smith, Rachel J; Aston-Jones, Gary

    2014-01-01

    Previous studies from our laboratory found that rats express increased preference for drug-paired stimuli following 2 or 5 weeks of protracted abstinence from chronic drug exposure as compared with naive animals. Here, we show that this increased morphine place preference depends upon experiencing drug-stimulus pairings specifically in the abstinent state, indicating a critical role for incentive learning. Male Sprague Dawley rats were initially conditioned for morphine place preference (8 mg/kg) and then made dependent on morphine (by subcutaneous morphine pellets) and subjected to forced abstinence. Place preference was tested every 1–2 weeks with no additional drug-cue conditioning. In this paradigm, there was no difference between morphine-pelleted (dependent) and placebo-pelleted (non-dependent) rats in place preference at any time during abstinence (up to 6 weeks). However, these same morphine-pelleted rats expressed significantly increased preference when they were subsequently re-conditioned for morphine place preference during protracted abstinence. Placebo-pelleted rats did not show enhanced preference after re-conditioning. These findings reveal that incentive learning has a key role in increased morphine place preference when drug is experienced during protracted abstinence. This indicates that incentive learning is involved not only in instrumental responding (as previously reported), but also in updating Pavlovian-conditioned responses to morphine-associated stimuli. Therefore, enhanced morphine preference is not a direct consequence of the negative affective state of abstinence, but instead reflects increased acquisition of morphine-stimulus associations during abstinence. These results indicate that, during the development of addiction in humans, drug-associated stimuli acquire increasingly stronger incentive properties each time they are re-experienced. PMID:23942418

  16. What is the role of harm reduction when drug users say they want abstinence?

    PubMed

    Neale, Joanne; Nettleton, Sarah; Pickering, Lucy

    2011-05-01

    Quantitative survey data indicate that most drug users starting treatment want abstinence rather than harm reduction (McKeganey et al., 2004). This finding has been seized upon by those seeking 'evidence' that abstinence is the bedrock of recovery and harm reduction is a negative and oppositional philosophy. However, all research involves questions of meaning, definition and value and an alternative research paradigm and different study design can provide important additional insights into treatment aspirations, including the desire for abstinence. Qualitative interviews conducted with 30 recovering heroin users (15 males and 15 females) in Southern England in 2009 confirm that those starting treatment often report a desire for abstinence. Nonetheless, drug users are frequently uncertain about their ability to achieve this and can have very different and inconsistent understandings of what being abstinent means. We suggest that the work of the critical theorist Habermas (1970, 1991) could improve our understanding of abstinence and is consistent with recent efforts to achieve a working definition of recovery. Importantly, our qualitative data also reveal that drug users have treatment aspirations that extend far beyond their drug consumption. They additionally want to improve relationships, engage in meaningful activities, acquire material possessions, and achieve better mental and physical health. Moreover, these broader life goals are often inextricably linked to their drug taking. From this, we conclude that both abstinence and harm reduction discourses should more routinely prioritise the many diverse 'wellness' goals that so clearly motivate treatment clients. The harm reduction field will then likely find that it has more in common with abstinence-oriented services and the broader recovery agenda than it might otherwise have imagined. PMID:21055914

  17. Characterization of babies discharged from Cabell Huntington Hospital during the calendar year 2005 with the diagnoses of neonatal abstinence syndrome.

    PubMed

    Baxter, F Ross; Nerhood, Robert; Chaffin, David

    2009-01-01

    Recent concern regarding the impact of maternal drug abuse on neonatal well being was the impetus for this retrospective cohort study of newborns diagnosed with neonatal abstinence syndrome that were discharged from Cabell Huntington Hospital during the calendar year 2005. Medical records of the neonates and their mothers were analyzed for a variety of health related outcomes and healthcare cost. Forty-eight neonates were diagnosed with Neonatal Abstinence Syndrome in 2005, forty of which required NICU assistance. The average maternal age at delivery was 26; gravity was 3.1 and most were single, separated or divorced. The majority had poor or inconsistent prenatal care. Twenty-one delivered by cesarean section most often for fetal distress. Most delivered prematurely with an average gestation of 35.9 weeks. Half of the mothers went into preterm labor with half of those having premature ruptured membranes. Opiates were the most common maternal substance found, while neonates most often tested positive for methadone. Nearly 90% of the mothers smoked. Thirty-four of the mothers were found to continue illicit drug abuse while pregnant, while another eight were seen in a methadone clinic for a history of abuse. Most of the neonates required weaning with methadone. The majority of our study cases were funded by Medicaid, mostly by West Virginia with total hospital costs exceeding 1.7 million dollars. Direct cost attributed to detoxification was in excess of $180,000. The number of neonates diagnosed with Neonatal Abstinence Syndrome has nearly tripled from 2003 to 2007. The problem of maternal drug abuse and addiction during pregnancy has dramatic effects on both their unborn children and our local healthcare system. Increased awareness of this growing problem is needed so that earlier interventions can be implemented. It is our opinion that all obstetrical patients at risk should be screened early and often so that those affected individuals can be managed more

  18. Ethyl glucuronide concentration in hair for detecting heavy drinking and/or abstinence: a meta-analysis.

    PubMed

    Boscolo-Berto, Rafael; Viel, Guido; Montisci, Massimo; Terranova, Claudio; Favretto, Donata; Ferrara, Santo Davide

    2013-05-01

    In both clinical and forensic settings, hair analysis for ethyl glucuronide (HEtG) has been increasingly employed for diagnosing chronic excessive drinking and, more recently, for monitoring abstinence. This paper aims at meta-analysing published data on HEtG concentrations in teetotallers, social drinkers and heavy drinkers in order to evaluate the use of this marker in hair for identifying chronic excessive drinking and for monitoring abstinence. In May 2012, a systematic multi-database search retrieved 366 records related to HEtG and further screened for relevant publications in the field. Fifteen (4.1 %) records matched the selection criteria and were included in the meta-analysis. The mean and 95 % confidence intervals (CI) of HEtG concentrations in social drinkers (mean 7.5 pg/mg; 95 % CI 4.7-10.2 pg/mg; p < 0.001), heavy drinkers (mean 142.7 pg/mg; 95 % CI 99.9-185.5 pg/mg; p < 0.001) and deceased subjects with a known history of chronic excessive drinking (mean 586.1 pg/mg; 95 % CI 177.2-995.0 pg/mg; p < 0.01) were calculated. The ranges of mean values and 95 % confidence intervals for single studies involving teetotallers/social or social/heavy drinkers showed a partial overlap with a down-trespassing of both the 7 and 30 pg/mg thresholds for social and heavy drinkers, respectively. Although larger and well-designed population studies are required to draw any definitive conclusion, our data show that the cut-off of 30 pg/mg limits the false-negative effect in differentiating heavy from social drinkers, whereas the recently proposed 7 pg/mg cut-off value might only be used for suspecting an active alcohol use, and not for proving complete abstinence. PMID:23250386

  19. Predictors of motivation for abstinence at the end of outpatient substance abuse treatment.

    PubMed

    Laudet, Alexandre B; Stanick, Virginia

    2010-06-01

    Commitment to abstinence, a motivational construct, is a strong predictor of reductions in drug and alcohol use. Level of commitment to abstinence at treatment end predicts sustained abstinence, a requirement for recovery. This study sought to identify predictors of commitment to abstinence at treatment end to guide clinical practice and to inform the conceptualization of motivational constructs. Polysubstance users (N = 250) recruited at the start of outpatient treatment were reinterviewed at the end of services. Based on the extant literature, potential predictors were during treatment measures of substance use and related cognitions, psychological functioning, recovery supports, stress, quality of life satisfaction, and treatment experiences. In multivariate analyses, perceived harm of future drug use, abstinence self-efficacy, quality of life satisfaction, and number of network members in 12-step recovery contributed 26.6% of the variance explained in the dependent variable, a total of 49.6% when combined with the control variables (demographics and baseline level of the outcome). Gender subgroup analyses yielded largely similar results. Clinical implications of findings for maximizing commitment to abstinence when clients leave treatment are discussed as are future research directions. PMID:20185267

  20. Cortical activation during delay discounting in abstinent methamphetamine dependent individuals

    PubMed Central

    Schwartz, Daniel L.; Huckans, Marilyn S.; McFarland, Bentson H.; Meiri, Gal; Stevens, Alexander A.; Mitchell, Suzanne H.

    2010-01-01

    Background Methamphetamine (MA)-dependent individuals prefer smaller immediate over larger delayed rewards in delay discounting (DD) tasks. Human and animal data implicate ventral (amygdala, ventral striatum, ventrolateral prefrontal cortex insula) and dorsal (dorsolateral prefrontal cortex, dorsal anterior cingulate cortex and posterior parietal cortex) systems in DD decisions. The ventral system is hypothesized to respond to the salience and immediacy of rewards while the dorsal system is implicated in the process of comparison and choice. Methods We used functional Magnetic Resonance Imaging to probe the neural correlates of DD in 19 recently abstinent MA-dependent patients and 17 age- and gender-matched controls. Results Hard DD choices were associated with greatest activation in bilateral middle cingulate, posterior parietal cortex (PPC), and the right rostral insula. Control subjects showed more activation than MA patients bilaterally in the precuneus and in the right caudate nucleus, anterior cingulate cortex (ACC), and dorsolateral prefrontal cortex (DLPFC). Magnitude of discounting was correlated with activity in the amygdala, DLPFC, posterior cingulate cortex and PPC. Conclusions Our findings were consistent with a model wherein dorsal cognitive systems modulate the neural response of ventral regions. Patients addicted to MA, who strongly prefer smaller immediate over larger delayed rewards, activate the dorsal cognitive control system in order to overcome their preference. Activation of the amygdala during choice of delayed rewards was associated with a greater degree of discounting, suggesting that heavily discounting MA-dependent individuals may be more responsive to the negative salience of delayed rewards than controls. PMID:18685833

  1. Moral Violations Reduce Oral Consumption.

    PubMed

    Chan, Cindy; Van Boven, Leaf; Andrade, Eduardo B; Ariely, Dan

    2014-07-01

    Consumers frequently encounter moral violations in everyday life. They watch movies and television shows about crime and deception, hear news reports of corporate fraud and tax evasion, and hear gossip about cheaters and thieves. How does exposure to moral violations influence consumption? Because moral violations arouse disgust and because disgust is an evolutionarily important signal of contamination that should provoke a multi-modal response, we hypothesize that moral violations affect a key behavioral response to disgust: reduced oral consumption. In three experiments, compared with those in control conditions, people drank less water and chocolate milk while (a) watching a film portraying the moral violations of incest, (b) writing about moral violations of cheating or theft, and (c) listening to a report about fraud and manipulation. These findings imply that "moral disgust" influences consumption in ways similar to core disgust, and thus provide evidence for the associations between moral violations, emotions, and consumer behavior. PMID:25125931

  2. Moral Violations Reduce Oral Consumption

    PubMed Central

    Chan, Cindy; Van Boven, Leaf; Andrade, Eduardo B.; Ariely, Dan

    2014-01-01

    Consumers frequently encounter moral violations in everyday life. They watch movies and television shows about crime and deception, hear news reports of corporate fraud and tax evasion, and hear gossip about cheaters and thieves. How does exposure to moral violations influence consumption? Because moral violations arouse disgust and because disgust is an evolutionarily important signal of contamination that should provoke a multi-modal response, we hypothesize that moral violations affect a key behavioral response to disgust: reduced oral consumption. In three experiments, compared with those in control conditions, people drank less water and chocolate milk while (a) watching a film portraying the moral violations of incest, (b) writing about moral violations of cheating or theft, and (c) listening to a report about fraud and manipulation. These findings imply that “moral disgust” influences consumption in ways similar to core disgust, and thus provide evidence for the associations between moral violations, emotions, and consumer behavior. PMID:25125931

  3. Cocaine Self-Administration Experience Induces Pathological Phasic Accumbens Dopamine Signals and Abnormal Incentive Behaviors in Drug-Abstinent Rats

    PubMed Central

    Wang, Xuefei; Sugam, Jonathan A.; Carelli, Regina M.

    2016-01-01

    Chronic exposure to drugs of abuse is linked to long-lasting alterations in the function of limbic system structures, including the nucleus accumbens (NAc). Although cocaine acts via dopaminergic mechanisms within the NAc, less is known about whether phasic dopamine (DA) signaling in the NAc is altered in animals with cocaine self-administration experience or if these animals learn and interact normally with stimuli in their environment. Here, separate groups of rats self-administered either intravenous cocaine or water to a receptacle (controls), followed by 30 d of enforced abstinence. Next, all rats learned an appetitive Pavlovian discrimination and voltammetric recordings of real-time DA release were taken in either the NAc core or shell of cocaine and control subjects. Cocaine experience differentially impaired DA signaling in the core and shell relative to controls. Although phasic DA signals in the shell were essentially abolished for all stimuli, in the core, DA did not distinguish between cues and was abnormally biased toward reward delivery. Further, cocaine rats were unable to learn higher-order associations and even altered simple conditioned approach behaviors, displaying enhanced preoccupation with cue-associated stimuli (sign-tracking; ST) but diminished time at the food cup awaiting reward delivery (goal-tracking). Critically, whereas control DA signaling correlated with ST behaviors, cocaine experience abolished this relationship. These findings show that cocaine has persistent, differential, and pathological effects on both DA signaling and DA-dependent behaviors and suggest that psychostimulant experience may remodel the very circuits that bias organisms toward repeated relapse. SIGNIFICANCE STATEMENT Relapsing to drug abuse despite periods of abstinence and sincere attempts to quit is one of the most pernicious facets of addiction. Unfortunately, little is known about how the dopamine (DA) system functions after periods of drug abstinence

  4. Effective Lagrangian approach to fermion electric dipole moments induced by a CP-violating WW{gamma} vertex

    SciTech Connect

    Novales-Sanchez, H.; Toscano, J. J.

    2008-01-01

    The one-loop contribution of the two CP-violating components of the WW{gamma} vertex, {kappa}-tilde{sub {gamma}}W{sub {mu}}{sup +}W{sub {nu}}{sup -}F-tilde{sup {mu}}{sup {nu}} and ({lambda}-tilde{sub {gamma}}/m{sub W}{sup 2})W{sub {mu}}{sub {nu}}{sup +}W{sub {rho}}{sup -{nu}}F-tilde{sup {rho}}{sup {mu}}, on the electric dipole moment (EDM) of fermions is calculated using dimensional regularization and its impact at low energies reexamined in the light of the decoupling theorem. The Ward identities satisfied by these couplings are derived by adopting a SU{sub L}(2)xU{sub Y}(1)-invariant approach and their implications in radiative corrections discussed. Previous results on {kappa}-tilde{sub {gamma}}, whose bound is updated to |{kappa}-tilde{sub {gamma}}|<5.2x10{sup -5}, are reproduced, but disagreement with those existing for {lambda}-tilde{sub {gamma}} is found. In particular, the upper bound |{lambda}-tilde{sub {gamma}}|<1.9x10{sup -2} is found from the limit on the neutron EDM, which is more than 2 orders of magnitude less stringent than that of previous results. It is argued that this difference between the {kappa}-tilde{sub {gamma}} and {lambda}-tilde{sub {gamma}} bounds is the one that might be expected in accordance with the decoupling theorem. This argument is reinforced by analyzing carefully the low-energy behavior of the loop functions. The upper bounds on the W EDM, |d{sub W}|<6.2x10{sup -21} e{center_dot}cm, and the magnetic quadrupole moment, |Q-tilde{sub W}|<3x10{sup -36} e{center_dot}cm{sup 2}, are derived. The EDM of the second and third families of quarks and charged leptons are estimated. In particular, EDM as large as 10{sup -20} e{center_dot}cm and 10{sup -21} e{center_dot}cm are found for the t and b quarks, respectively.

  5. Models of dynamical R-parity violation

    NASA Astrophysics Data System (ADS)

    Csáki, Csaba; Kuflik, Eric; Slone, Oren; Volansky, Tomer

    2015-06-01

    The presence of R-parity violating interactions may relieve the tension between existing LHC constraints and natural supersymmetry. In this paper we lay down the theoretical framework and explore models of dynamical R-parity violation in which the breaking of R-parity is communicated to the visible sector by heavy messenger fields. We find that R-parity violation is often dominated by non-holomorphic operators that have so far been largely ignored, and might require a modification of the existing searches at the LHC. The dynamical origin implies that the effects of such operators are suppressed by the ratio of either the light fermion masses or the supersymmetry breaking scale to the mediation scale, thereby providing a natural explanation for the smallness of R-parity violation. We consider various scenarios, classified by whether R-parity violation, flavor breaking and/or supersymmetry breaking are mediated by the same messenger fields. The most compact case, corresponding to a deformation of the so called flavor mediation scenario, allows for the mediation of supersymmetry breaking, R-parity breaking, and flavor symmetry breaking in a unified manner.

  6. CP violation in heavy MSSM Higgs scenarios

    DOE PAGESBeta

    Carena, M.; Ellis, J.; Lee, J. S.; Pilaftsis, A.; Wagner, C. E. M.

    2016-02-18

    We introduce and explore new heavy Higgs scenarios in the Minimal Supersymmetric Standard Model (MSSM) with explicit CP violation, which have important phenomenological implications that may be testable at the LHC. For soft supersymmetry-breaking scales MS above a few TeV and a charged Higgs boson mass MH+ above a few hundred GeV, new physics effects including those from explicit CP violation decouple from the light Higgs boson sector. However, such effects can significantly alter the phenomenology of the heavy Higgs bosons while still being consistent with constraints from low-energy observables, for instance electric dipole moments. To consider scenarios with amore » charged Higgs boson much heavier than the Standard Model (SM) particles but much lighter than the supersymmetric particles, we revisit previous calculations of the MSSM Higgs sector. We compute the Higgs boson masses in the presence of CP violating phases, implementing improved matching and renormalization-group (RG) effects, as well as two-loop RG effects from the effective two-Higgs Doublet Model (2HDM) scale MH± to the scale MS. Here, we illustrate the possibility of non-decoupling CP-violating effects in the heavy Higgs sector using new benchmark scenarios named.« less

  7. Time reversal invariance violation in neutron-deuteron scattering

    SciTech Connect

    Song, Young-Ho; Gudkov, Vladimir; Lazauskas, Rimantas

    2011-06-15

    Time reversal invariance-violating (TRIV) effects in low-energy elastic neutron-deuteron scattering are calculated using meson exchange and EFT-type TRIV potentials in a distorted-wave Born approximation with realistic hadronic strong interaction wave functions, obtained by solving the three-body Faddeev equations in configuration space. The relation between TRIV and parity-violating observables is discussed.

  8. Smoking- and menstrual-related symptomatology during short-term smoking abstinence by menstrual phase and depressive symptoms.

    PubMed

    Allen, Sharon S; Allen, Alicia M; Tosun, Nicole; Lunos, Scott; al'Absi, Mustafa; Hatsukami, Dorothy

    2014-05-01

    Menstrual phase and depressive symptoms are known to minimize quit attempts in women. Therefore, the influence of these factors on smoking- and menstrual-related symptomatology during acute smoking cessation was investigated in a controlled cross-over lab-study. Participants (n=147) completed two six-day testing weeks during their menstrual cycle with testing order randomly assigned (follicular vs. luteal). The testing week consisted of two days of ad libitum smoking followed by four days of biochemically verified smoking abstinence. Daily symptomatology measures were collected. Out of the 11 total symptoms investigated, six were significantly associated with menstrual phase and nine were significantly associated with level of depressive symptoms. Two significant interactions were noted indicating that there may be a stronger association between depressive symptoms with negative affect and premenstrual pain during the follicular phase compared to the luteal phase. Overall, these observations suggest that during acute smoking abstinence in premenopausal smokers, there is an association between depressive symptoms and symptomatology whereas menstrual phase appears to have less of an effect. Further study is needed to determine the effect of these observations on smoking cessation outcomes, as well as to define the mechanism of menstrual phase and depressive symptoms on smoking-related symptomatology. PMID:24594903

  9. CPT Violation: What and where to look for

    SciTech Connect

    Mavromatos, Nick E.

    2005-10-26

    In this review I classify the possible ways of CPT violation, and I describe briefly their phenomenology, in both terrestrial and astrophysical experiments, including antimatter factories, neutral mesons and neutrinos, and discuss the various sensitivities. I also pay attention to disentangling genuine quantum-gravity induced CPT violation from 'fake' violation due to ordinary matter effects. A particularly interesting situation arises when the breaking of CPT invariance is through unitarity violations, in the sense of the matter theory being viewed as an effective field theory, entangled with decoherening quantum gravity 'environments'. In such a case the quantum mechanical CPT operator is ill defined due to another mathematical theorem, and one has novel effects associated with CPT Violating modifications of Einstein-Podolsky-Rosen type correlations of entangled meson states in B and {phi} meson factories.

  10. CP violation in hadronic τ decays

    NASA Astrophysics Data System (ADS)

    Datta, Alakabha; Kiers, Ken; London, David; O'Donnell, Patrick J.; Szynkman, Alejandro

    2007-04-01

    We reexamine CP violation in the ΔS=0 decays τ→Nπντ (N=2,3,4). We assume that the new physics (NP) is a charged Higgs boson. We show that there is no NP contribution to τ→ππντ, which means that no CP violation is expected in this decay. On the other hand, NP can contribute to τ→Nπντ (N=3,4). These are dominated by the intermediate resonant decays τ→ωπντ, τ→ρπντ, and τ→a1πντ. We show that the only sizeable CP-violating effects which are possible are in τ→a1πντ→4πντ (polarization-dependent rate asymmetry) and τ→ωπντ (triple-product asymmetry).

  11. Violation of detailed balance accelerates relaxation

    NASA Astrophysics Data System (ADS)

    Ichiki, Akihisa; Ohzeki, Masayuki

    2013-08-01

    Recent studies have experienced the acceleration of convergence in Markov chain Monte Carlo methods implemented by the systems without detailed balance condition (DBC). However, such advantage of the violation of DBC has not been confirmed in general. We investigate the effect of the absence of DBC on the convergence toward equilibrium. Surprisingly, it is shown that the DBC violation always makes the relaxation faster. Our result implies the existence of a kind of thermodynamic inequality that connects the nonequilibrium process relaxing toward steady state with the relaxation process which has the same probability distribution as its equilibrium state.

  12. Relativistic four- and two-component calculations of parity violation effects in chiral tungsten molecules of the form NWXYZ (X, Y, Z = H, F, Cl, Br, or I).

    PubMed

    Figgen, Detlev; Saue, Trond; Schwerdtfeger, Peter

    2010-06-21

    Parity violation (PV) effects to the electronic ground state structure for a series of chiral tungsten molecules of the type NWXYZ (X, Y, Z = H, F, Cl, Br, or I) are compared using four- (Dirac) and two- (X2C) component relativistic Hartree-Fock and density functional theories. The results show the computationally more affordable two-component X2C approach yields accurate results for all molecules investigated. The PV energy differences between the two enantiomers range from as little as 0.4 Hz for NWClBrI to 140 Hz for NWHClI using a generalized gradient approximation including exact exchange (B3LYP). The W-N stretching mode in these molecules lies in the experimentally favorable CO(2) laser frequency range, and we therefore investigated PV effects in vibrational transitions using a single normal mode analysis. Here the PV frequency shift between the two enantiomers ranges from 1.6 mHz for NWFBrI to 710 mHz for NWHClI. Thus these types of molecules could be useful for the future detection of PV effects in chiral molecules. PMID:20572708

  13. Musical Expertise Modulates Early Processing of Syntactic Violations in Language

    PubMed Central

    Fitzroy, Ahren B.; Sanders, Lisa D.

    2013-01-01

    Syntactic violations in speech and music have been shown to elicit an anterior negativity (AN) as early as 100 ms after violation onset and a posterior positivity that peaks at roughly 600 ms (P600/LPC). The language AN is typically reported as left-lateralized (LAN), whereas the music AN is typically reported as right-lateralized (RAN). However, several lines of evidence suggest syntactic processing of language and music rely on overlapping neural systems. The current study tested the hypothesis that syntactic processing of speech and music share neural resources by examining whether musical proficiency modulates ERP indices of linguistic syntactic processing. ERPs were measured in response to syntactic violations in sentences and chord progressions in musicians and non-musicians. Violations in speech were insertion errors in normal and semantically impoverished English sentences. Violations in music were out-of-key chord substitutions from distantly and closely related keys. Phrase-structure violations elicited an AN and P600 in both groups. Harmonic violations elicited an LPC in both groups, blatant harmonic violations also elicited a RAN in musicians only. Cross-domain effects of musical proficiency were similar to previously reported within-domain effects of linguistic proficiency on the distribution of the language AN; syntactic violations in normal English sentences elicited a LAN in musicians and a bilateral AN in non-musicians. The late positivities elicited by violations differed in latency and distribution between domains. These results suggest that initial processing of syntactic violations in language and music relies on shared neural resources in the general population, and that musical expertise results in more specialized cortical organization of syntactic processing in both domains. PMID:23335905

  14. Prenatal Methadone Exposure, Meconium Biomarker Concentrations and Neonatal Abstinence Syndrome

    PubMed Central

    Gray, Teresa R.; Choo, Robin E.; Concheiro, Marta; Williams, Erica; Elko, Andrea; Jansson, Lauren M.; Jones, Hendrée E.; Huestis, Marilyn A.

    2010-01-01

    Aims Methadone is standard pharmacotherapy for opioid-dependent pregnant women, yet the relationship between maternal methadone dose and neonatal abstinence syndrome (NAS) severity is still unclear. This research evaluated whether quantification of fetal methadone and drug exposure via meconium would reflect maternal dose and predict neonatal outcomes. Design Prospective clinical study Setting An urban drug treatment facility treating pregnant and post-partum women and their children Participants Forty-nine opioid-dependent pregnant women received 30–110 mg methadone daily. Measurements Maternal methadone dose, infant birth parameters and NAS assessments were extracted from medical records. Thrice-weekly urine specimens were screened for opioids and cocaine. Newborn meconium specimens were quantified for methadone, opioid, cocaine and tobacco biomarkers. Findings There was no relationship between meconium methadone concentrations, presence of opioids, cocaine and/or tobacco in meconium, maternal methadone dose or NAS severity. Opioid, cocaine and tobacco biomarkers also were found in 36.7, 38.7 and 81.1% of meconium specimens, respectively, and were associated with positive urine specimens in the third trimester. The presence of opioids other than methadone in meconium correlated with increased rates of preterm birth, longer infant hospital stays and decreased maternal time in drug treatment. Conclusions Methadone and its metabolite 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP) concentrations in meconium did not predict infant birth parameters or NAS severity. Prospective urine testing defined meconium drug detection windows for opiates and cocaine as three months, rather than the currently accepted six months. The presence of opioids in meconium could be used as a biomarker for infants at elevated risk in the newborn period. PMID:20854338

  15. Incidence of Neonatal Abstinence Syndrome - 28 States, 1999-2013.

    PubMed

    Ko, Jean Y; Patrick, Stephen W; Tong, Van T; Patel, Roshni; Lind, Jennifer N; Barfield, Wanda D

    2016-01-01

    Neonatal abstinence syndrome (NAS) is a postnatal drug withdrawal syndrome that occurs primarily among opioid-exposed infants shortly after birth, often manifested by central nervous system irritability, autonomic overreactivity, and gastrointestinal tract dysfunction (1). During 2000-2012, the incidence of NAS in the United States significantly increased (2,3). Several recent publications have provided national estimates of NAS (2,3); however, data describing incidence at the state level are limited. CDC examined state trends in NAS incidence using all-payer, hospital inpatient delivery discharges compiled in the State Inpatient Databases of the Healthcare Cost and Utilization Project (HCUP) during 1999-2013. Among 28 states with publicly available data in HCUP during 1999-2013, the overall NAS incidence increased 300%, from 1.5 per 1,000 hospital births in 1999, to 6.0 per 1,000 hospital births in 2013. During the study period, significant increases in NAS incidence occurred in 25 of 27 states with at least 3 years of data, with annual incidence rate changes ranging from 0.05 (Hawaii) to 3.6 (Vermont) per 1,000 births. In 2013, NAS incidence ranged from 0.7 cases per 1,000 hospital births (Hawaii) to 33.4 cases per 1,000 hospital births (West Virginia). The findings underscore the importance of state-based public health programs to prevent unnecessary opioid use and to treat substance use disorders during pregnancy, as well as decrease the incidence of NAS. PMID:27513154

  16. Violation of Bell's inequalities in quantum optics

    NASA Technical Reports Server (NTRS)

    Reid, M. D.; Walls, D. F.

    1984-01-01

    An optical field produced by intracavity four-wave mixing is shown to exhibit the following nonclassical features: photon antibunching, squeezing, and violation of Cauchy-Schwarz and Bell's inequalities. These intrinsic quantum mechanical effects are shown to be associated with the nonexistence of a positive normalizable Glauber-Sudarshan P function.

  17. Lorentz violating Julia-Toulouse mechanism

    NASA Astrophysics Data System (ADS)

    Gaete, Patricio; Wotzasek, Clovis

    2007-03-01

    We study a Lorentz invariance violating extension for the pure photonic sector of the standard model. A phenomenological proposal is made for the condensation of topological defects in the presence of a constant rank-m tensor in the context of the Julia-Toulouse mechanism. Possible physical consequences leading to direct measurable effects over the confining properties of the elementary particles are explored.

  18. On the influence of a Rashba-type coupling induced by Lorentz-violating effects on a Landau system for a neutral particle

    SciTech Connect

    Bakke, K.; Belich, H.

    2015-03-15

    We study a possible scenario of the Lorentz symmetry violation background that allows us to build an analogue of the Landau system for a nonrelativistic Dirac neutral particle interacting with a field configuration of crossed electric and magnetic fields. We also discuss the arising of analogues of the Rashba coupling, the Zeeman term and the Darwin term from the Lorentz symmetry breaking effects, and the influence of these terms on the analogue of the Landau system confined to a two-dimensional quantum ring. Finally, we show that this analogy with the Landau system confined to a two-dimensional quantum ring allows us to establish an upper bound for the Lorentz symmetry breaking parameters. - Highlights: • Landau system from crossed electric and magnetic fields and fixed time-like vector. • Analogues of the Rashba coupling, the Zeeman term and the Darwin term. • Lorentz symmetry breaking effects on a two-dimensional quantum ring. • Upper bound for the Lorentz symmetry breaking parameters.

  19. Relations between in-treatment and follow-up abstinence among cocaine-dependent homeless persons in three clinical trials.

    PubMed

    Vuchinich, Rudy; Wallace, Dennis; Milby, Jesse B; Schumacher, Joseph E; Mennemeyer, Stephen; Kertesz, Stefan

    2009-06-01

    Clinical trials with cocaine-dependent outpatients have found a strong relation between in-treatment and follow-up abstinence, and the strength of this relation is constant across treatment conditions with variable efficacy in generating abstinence. The authors conducted secondary analyses of data from 3 clinical trials to determine whether this relation generalizes to cocaine-dependent homeless persons. The 3 trials (total N = 543) were conducted in a community health care facility for homeless people. The 7 treatment arms across the 3 trials were combinations of day treatment, abstinence-contingent housing, and vocational training. Drug use was measured with urine toxicology testing. Consecutive weeks of abstinence during treatment were strongly related to abstinence at the 12-month follow-up, whether or not missing 12-month data were included in the analysis. The treatment arms differed in their efficacy in generating abstinence, but the relation between in-treatment and follow-up abstinence did not differ across treatment arms. These results replicate earlier reports of these relations and extend them to a population of homeless people. The lack of differences between treatment arms in the in-treatment-follow-up abstinence relation implies that that relation is independent of the treatment-specific intervention components that generate group differences in abstinence. PMID:19586231

  20. Sailing against the tide? Sustaining sexual abstinence among Christian youth in a university setting in South Africa.

    PubMed

    Mbotho, Mbali; Cilliers, Michelle; Akintola, Olagoke

    2013-03-01

    This qualitative study sought to understand the perceptions and experiences of abstinence among young Christians in a University in South Africa. Willingness to adhere to Christian teachings of sexual chastity is the primary motivation for sexual abstinence while spiritual, mental and physical health benefits of abstinence as well as enforcement of Christian teachings by members and peers are secondary motivations that help sustain sexual abstinence. Sexual pressures come from desire to satisfy sexual urge, subtle coercion, peer pressure, momentary loss of self-control. There is need for multi-pronged interventions aimed at empowering Christian youth to deal with sources of sexual pressures. PMID:21253847

  1. CP violation at ATLAS

    NASA Astrophysics Data System (ADS)

    Barton, Adam; Atlas Collaboration

    2013-07-01

    A measurement of several properties of the Bs meson, including the CP-violating weak phase phis and the mixing-induced width difference ΔΓs, is performed using the decay Bs → J/ψ(μ+μ-)phi(K+K-), from a dataset of 4.9 fb-1 of integrated luminosity collected in 2011 by the ATLAS detector at the LHC. The measured parameters are consistent with the world average values and theoretical expectations; in particular phis is within 1 σ of the expected value in the Standard Model.

  2. CP Violation in B Mesons

    SciTech Connect

    Lazzaro, Alfio; /Milan U. /INFN, Milan

    2007-05-11

    Symmetries and their conservation laws play a fundamental role in Physics. Among them, the discrete symmetries corresponding to charge (C), parity (P), and time (T) transformations are extensively used in the theory of the elementary particles and their interactions (so called Standard Model (SM)) to give the basis of the fundamental physical description of nature. Eventual discoveries of violations of these symmetries become a crucial test for our understanding of the nature. It was assumed that the three discrete symmetries were not violated until 1956 when it was found that P is violated in the weak interaction. Soon it was understood that also the C is violated in the weak interaction. At that time these two violated symmetries were replaced by their combination, CP, which was considered a new fundamental symmetry. In 1964 also the CP was found violated in the case of the neutral K meson system. Since that year there were many achievements in theories and experiments in order to explain this symmetry violation. In the last five years the main contribution comes from the discovery of the CP violation in B meson system. In this note we will describe briefly how the CP violation is described in the SM and the main experimental results obtained in the B mesons system.

  3. Provider views of harm reduction versus abstinence policies within homeless services for dually diagnosed adults

    PubMed Central

    Padgett, Deborah K.; Tiderington, Emmy

    2013-01-01

    Harm reduction is considered by many to be a legitimate alternative to abstinence-based services for dually diagnosed individuals, yet there is limited understanding of how varying approaches affect front-line practice within supportive housing services for homeless adults. This paper examines how front-line providers working with individuals who have experienced homelessness, serious mental illness, and addiction view policies of harm reduction versus abstinence within two distinctly different approaches to homeless services: the traditional or ‘treatment first’ (TF) approach that requires abstinence and the more recent Housing First (HF) approach that incorporates harm reduction. As part of a federally-funded qualitative study, 129 in-depth interviews conducted with 41 providers were thematically analyzed to understand how providers view a harm reduction versus abstinence approach. Themes included: (a) harm reduction as a welcomed alternative; (b) working with ambiguity; and (c) accommodating abstinence. Drawing on recovery principles, we consider the broader implications of the findings for behavioral health care with this population. PMID:23404076

  4. Cocaine abstinence following chronic treatment alters cerebral metabolism in dopaminergic reward regions. Bromocriptine enhances recovery

    SciTech Connect

    Clow, D.W.; Hammer, R.P. Jr. )

    1991-01-01

    2-(14C)deoxyglucose autoradiography was used to determine local cerebral glucose utilization (lCGU) in rats following chronic cocaine treatment and subsequent abstinence. lCGU was examined in 43 discrete brain regions in animals which had received daily injections of cocaine for 14 days (10 mg/kg) followed by 3 days of saline or bromocriptine (10 mg/kg) treatment. Cocaine abstinence following chronic treatment significantly reduced lCGU in several regions including mesocorticolimbic structures such as ventral tegmental area, medial prefrontal cortex, and nucleus accumbens (NAc). Within the NAc, however, only the rostral pole showed significant reduction. In contrast, when bromocriptine treatment accompanied abstinence, lCGU was no longer reduced in mesocorticolimbic and most other regions, implying that metabolic recovery was enhanced by bromocriptine treatment during early abstinence following chronic cocaine treatment. These data suggest that cerebral metabolism is decreased during cocaine abstinence following chronic treatment in critical brain regions, and that this alteration can be prevented by treatment with direct-acting dopamine agonists such as bromocriptine.

  5. A model to examine the validity of the 6-month abstinence criterion for liver transplantation.

    PubMed

    Yates, W R; Martin, M; LaBrecque, D; Hillebrand, D; Voigt, M; Pfab, D

    1998-04-01

    Six months of abstinence from alcohol is a commonly used criterion for liver transplantation eligibility for patients with alcoholic cirrhosis. There is limited evidence to document the validity of this criterion with regard to risk of alcoholism relapse. Ninety-one patients with alcoholic cirrhosis were interviewed for relapse risk using the High Risk Alcoholism Relapse (HRAR) Scale. The HRAR model can be used to predict relapse risk independent of duration of sobriety and therefore can be used to examine the validity of the 6 months of abstinence criteria in this clinical population. The two methods demonstrated poor to fair agreement. Agreement was highest with a cutoff allowing a 5% 6-month relapse risk when 79% agreement (c = 0.56) was demonstrated between the two methods. Using the 6-month abstinence criterion alone disallows a significant number of candidates who have a low relapse risk based on their HRAR score. The validity of the 6-month abstinence criterion is supported somewhat by comparison with the HRAR model. However, use of the 6-month abstinence criterion alone forces a significant number of patients with a low relapse risk by HRAR to wait for transplant listing. A relapse risk model based on an estimate of alcoholism severity in addition to duration of sobriety may more accurately select patients who are most likely to benefit from liver transplantation. PMID:9581661

  6. Synapse Density and Dendritic Complexity Are Reduced in the Prefrontal Cortex following Seven Days of Forced Abstinence from Cocaine Self-Administration

    PubMed Central

    Rasakham, Khampaseuth; Schmidt, Heath D.; Kay, Kevin; Huizenga, Megan N.; Calcagno, Narghes; Pierce, R. Christopher

    2014-01-01

    Chronic cocaine exposure in both human addicts and in rodent models of addiction reduces prefrontal cortical activity, which subsequently dysregulates reward processing and higher order executive function. The net effect of this impaired gating of behavior is enhanced vulnerability to relapse. Previously we have shown that cocaine-induced increases in brain-derived neurotrophic factor (BDNF) expression in the medial prefrontal cortex (PFC) is a neuroadaptive mechanism that blunts the reinforcing efficacy of cocaine. As BDNF is known to affect neuronal survival and synaptic plasticity, we tested the hypothesis that abstinence from cocaine self-administration would lead to alterations in neuronal morphology and synaptic density in the PFC. Using a novel technique, array tomography and Golgi staining, morphological changes in the rat PFC were analyzed following 14 days of cocaine self-administration and 7 days of forced abstinence. Our results indicate that overall dendritic branching and total synaptic density are significantly reduced in the rat PFC. In contrast, the density of thin dendritic spines are significantly increased on layer V pyramidal neurons of the PFC. These findings indicate that dynamic structural changes occur during cocaine abstinence that may contribute to the observed hypo-activity of the PFC in cocaine-addicted individuals. PMID:25072653

  7. Models of isospin violating ADM

    SciTech Connect

    Okada, Nobuchika; Seto, Osamu

    2014-06-24

    The isospin violating dark matter (IVDM) scenario offers an interesting possibility to reconcile conflicting results among direct dark matter search experiments for a mass range around 10 GeV. We consider two simple renormalizable IVDM models with a complex scalar dark matter and a Dirac fermion dark matter, respectively, whose stability is ensured by the conservation of “dark matter number.” Although both models successfully work as the IVDM scenario with destructive interference between effective couplings to proton and neutron, the dark matter annihilation cross section is found to exceed the cosmological/astrophysical upper bounds. Then, we propose a simple scenario to reconcile the IVDM scenario with the cosmological/astrophysical bounds, namely, the IVDM being asymmetric. We also discuss collider experimental constraints on the models and an implication to Higgs boson physics.

  8. Ondansetron Pharmacokinetics in Pregnant Women and Neonates: Towards a New Treatment for Neonatal Abstinence Syndrome

    PubMed Central

    Elkomy, Mohammed H.; Sultan, Pervez; Carvalho, Brendan; Peltz, Gary; Wu, Manhong; Clavijo, Claudia; Galinkin, Jeffery L.; Drover, David R.

    2014-01-01

    Ondansetron is the drug of choice to prevent nausea in women undergoing cesarean surgery and can be used to prevent neonatal abstinence syndrome (NAS). Pharmacokinetics of ondansetron has not been characterized in pregnant women or in newborns. A nonlinear mixed-effects modeling approach was used to analyze plasma samples obtained from 20 non-pregnant and 40 pregnant women following single administration of 4 or 8 mg ondansetron, from umbilical cord blood at delivery, and from neonates after birth. The analysis indicates that: ondansetron disposition is not affected by pregnancy (p>0.05), but influenced by dose (p<0.05), and is characterized by rapid transplacental transfer and longer elimination half-life in neonates compared to their mother. A dosing regimen for prevention of NAS was designed based on the model. The regimen involves IV administration of 4 mg to the mothers shortly before cord clamping, or oral administration of 0.07 mg/kg (or equivalently 0.04 mg/kg IV) to neonates. PMID:25670522

  9. Ondansetron pharmacokinetics in pregnant women and neonates: towards a new treatment for neonatal abstinence syndrome.

    PubMed

    Elkomy, M H; Sultan, P; Carvalho, B; Peltz, G; Wu, M; Clavijo, C; Galinkin, J L; Drover, D R

    2015-02-01

    Ondansetron is the drug of choice to prevent nausea in women undergoing cesarean surgery and can be used to prevent neonatal abstinence syndrome (NAS). The pharmacokinetics of ondansetron have not been characterized in pregnant women or in newborns. A nonlinear mixed-effects modeling approach was used to analyze plasma samples obtained from 20 nonpregnant and 40 pregnant women following a single administration of 4 or 8 mg ondansetron, from umbilical cord blood at delivery, and from neonates after birth. The analysis indicates that: ondansetron disposition is not affected by pregnancy (P > 0.05), but influenced by dose (P < 0.05), and is characterized by rapid transplacental transfer and longer elimination half-life in neonates compared to their mother. A dosing regimen for prevention of NAS was designed based on the model. The regimen involves IV administration of 4 mg to the mothers shortly before cord clamping, or oral administration of 0.07 mg/kg (or equivalently 0.04 mg/kg IV) to neonates. PMID:25670522

  10. Convergent evidence from alcohol-dependent humans and rats for a hyperdopaminergic state in protracted abstinence.

    PubMed

    Hirth, Natalie; Meinhardt, Marcus W; Noori, Hamid R; Salgado, Humberto; Torres-Ramirez, Oswaldo; Uhrig, Stefanie; Broccoli, Laura; Vengeliene, Valentina; Roßmanith, Martin; Perreau-Lenz, Stéphanie; Köhr, Georg; Sommer, Wolfgang H; Spanagel, Rainer; Hansson, Anita C

    2016-03-15

    A major hypothesis in addiction research is that alcohol induces neuroadaptations in the mesolimbic dopamine (DA) system and that these neuroadaptations represent a key neurochemical event in compulsive drug use and relapse. Whether these neuroadaptations lead to a hypo- or hyperdopaminergic state during abstinence is a long-standing, unresolved debate among addiction researchers. The answer is of critical importance for understanding the neurobiological mechanism of addictive behavior. Here we set out to study systematically the neuroadaptive changes in the DA system during the addiction cycle in alcohol-dependent patients and rats. In postmortem brain samples from human alcoholics we found a strong down-regulation of the D1 receptor- and DA transporter (DAT)-binding sites, but D2-like receptor binding was unaffected. To gain insight into the time course of these neuroadaptations, we compared the human data with that from alcohol-dependent rats at several time points during abstinence. We found a dynamic regulation of D1 and DAT during 3 wk of abstinence. After the third week the rat data mirrored our human data. This time point was characterized by elevated extracellular DA levels, lack of synaptic response to D1 stimulation, and augmented motor activity. Further functional evidence is given by a genetic rat model for hyperdopaminergia that resembles a phenocopy of alcohol-dependent rats during protracted abstinence. In summary, we provide a new dynamic model of abstinence-related changes in the striatal DA system; in this model a hyperdopaminergic state during protracted abstinence is associated with vulnerability for relapse. PMID:26903621

  11. Psychological symptoms are associated with both abstinence and risky sex among men with HIV.

    PubMed

    Miller, Carol T; Solomon, Sondra E; Bunn, Janice Y; Varni, Susan E; Hodge, James J

    2015-02-01

    Sexual abstinence is often deemed the "safest behavior" in HIV prevention, but is sometimes associated with psychological symptoms (e.g., depression) just as sexually risky behavior is. This study explored whether sexual abstinence and risky sexual behavior among men with HIV were associated with similar constellations of psychological symptoms. Prior research has not addressed this issue because abstinent people often are not included in the sample or, when data are analyzed, researchers combine abstinent people with sexually active people who practice safer sex. Past research also neglects the co-morbidity of psychological symptoms. A latent class analysis of the psychological symptoms (assessed with the Symptom Check List 90-R; Derogatis, 1994) of 140 men with HIV, mostly from rural New England, revealed three latent classes: men who were asymptomatic on all symptom domains (28.8 %), men who were symptomatic on all domains (34.1 %), and men who were symptomatic on internalizing domains (37.1 %), but were asymptomatic on the externalizing symptoms of hostility and paranoid ideation. Logistic regression showed that sexual behavior during the past 90 days of men in the all symptom class and the internalizing symptoms class was similar, with abstinence and risky sex predominating, and safer sex being relatively uncommon for both classes. The sexual behavior of men in the asymptomatic class differed, with safer sex being relatively more likely to occur compared to the symptomatic classes. These findings suggest that the psychological symptom profile of sexually abstinent people places them at risk for inconsistent condom use should they engage in sexual behavior. PMID:25614050

  12. Psychological Symptoms are Associated with Both Abstinence and Risky Sex among Men with HIV

    PubMed Central

    Miller, Carol T.; Solomon, Sondra E.; Bunn, Janice Y.; Varni, Susan E.; Hodge, James J.

    2015-01-01

    Sexual abstinence is often deemed the “safest behavior” in HIV prevention, but is sometimes associated with psychological symptoms (e.g., depression) just as sexually risky behavior is. This study explored whether sexual abstinence and risky sexual behavior among men with HIV are associated with similar constellations of psychological symptoms. Prior research has not addressed this issue because abstinent people often are not included in the sample, or when data are analyzed, researchers combine abstinent people with sexually active people who practice safer sex. Past research also neglects the co-morbidity of psychological symptoms. A latent class analysis of the psychological symptoms (assessed with the Symptom Check List 90-R; Derogatis, 1994) of 140 men with HIV, mostly from rural New England, revealed three latent classes; men who were asymptomatic on all symptom domains (28.8%), men who were symptomatic on all domains (34.1%), and men who were symptomatic on internalizing domains (37.1%), but were asymptomatic on the externalizing symptoms of hostility and paranoid ideation. Logistic regression showed that sexual behavior during the past 90 days of men in the all symptom class and the internalizing symptoms class was similar, with abstinence and risky sex predominating, and safer sex being relatively uncommon for both classes. The sexual behavior of men in the asymptomatic class differed, with safer sex being relatively more likely to occur compared to the symptomatic classes. These findings suggest that the psychological symptom profile of sexually abstinent people places them at risk for inconsistent condom use should they engage in sexual behavior. PMID:25614050

  13. Learning To Speak Out in an Abstinence Based Sex Education Group: Gender and Race Work in an Urban Magnet School.

    ERIC Educational Resources Information Center

    Weis, Lois

    This paper describes an abstinence-based sex education group for diverse girls in grades 7-12 in an urban magnet school. Data were gathered from a within-school program, My Bottom Line, which was designed to prevent or delay the onset of sexual activity, build self-esteem, and increase young women's self-sufficiency through an abstinence based,…

  14. Adult Discrimination against Children: The Case of Abstinence-Only Education in Twenty-First-Century USA

    ERIC Educational Resources Information Center

    Greslé-Favier, Claire

    2013-01-01

    This paper analyses abstinence-only education programmes and discourses within the frame of theories of adult discrimination against children. To begin with, a definition of abstinence-only programmes and of the political context in which they were created will be provided. These programmes will then be analysed through the lens of children's…

  15. Longitudinal Effects of School Drug Policies on Student Marijuana Use in Washington State and Victoria, Australia

    PubMed Central

    Plenty, Stephanie M.; Catalano, Richard F.; Herrenkohl, Todd I.; Toumbourou, John W.

    2015-01-01

    Objectives. We examined the longitudinal effect of schools’ drug policies on student marijuana use. Methods. We used data from the International Youth Development Study, which surveyed state-representative samples of students from Victoria, Australia, and Washington State. In wave 1 (2002), students in grades 7 and 9 (n = 3264) and a school administrator from each participating school (n = 188) reported on school drug policies. In wave 2 (2003), students reported on their marijuana use. We assessed associations between student-reported and administrator-reported policy and student self-reported marijuana use 1 year later. Results. Likelihood of student marijuana use was higher in schools in which administrators reported using out-of-school suspension and students reported low policy enforcement. Student marijuana use was less likely where students reported receiving abstinence messages at school and students violating school policy were counseled about the dangers of marijuana use. Conclusions. Schools may reduce student marijuana use by delivering abstinence messages, enforcing nonuse policies, and adopting a remedial approach to policy violations rather than use of suspensions. PMID:25790384

  16. Seesaw Models with Minimal Flavor Violation

    NASA Astrophysics Data System (ADS)

    He, Xiao-Gang

    In this talk, I discuss implementation of minimal flavor violation (MFV) in seesaw models based on work appeared in arXiv:1401.2615, arXiv:1404.4436 and arXiv:1411.6612. Phenomenological implications on flavor-changing interactions related to leptons are studied by considering some effective dimension-six operators. We also comment on how one of the new effective operators can induce flavor-changing dilepton decays of the Higgs boson.

  17. Lepton flavor violation and cosmological constraints on R-parity violation

    SciTech Connect

    Endo, Motoi; Hamaguchi, Koichi; Iwamoto, Sho E-mail: hama@hep-th.phys.s.u-tokyo.ac.jp

    2010-02-01

    In supersymmetric standard models R-parity violating couplings are severely constrained, since otherwise they would erase the existing baryon asymmetry before the electroweak transition. It is often claimed that this cosmological constraint can be circumvented if the baryon number and one of the lepton flavor numbers are sufficiently conserved in these R-parity violating couplings, because B/3−L{sub i} for each lepton flavor is separately conserved by the sphaleron process. We discuss the effect of lepton flavor violation on the B−L conservation, and show that even tiny slepton mixing angles θ{sub 12}∼>O(10{sup −4}) and θ{sub 23},θ{sub 13}∼>O(10{sup −5}) will spoil the separate B/3−L{sub i} conservation. In particular, if lepton flavor violations are observed in experiments such as MEG and B-factories, it will imply that all the R-parity violating couplings must be suppressed to avoid the B−L erasure. We also discuss the implication for the decay of the lightest MSSM particle at the LHC.

  18. Neutron-antineutron transition as a test-bed for dynamical CPT violations

    NASA Astrophysics Data System (ADS)

    Addazi, Andrea

    2016-05-01

    We show a simple mechanism for a dynamical CPT violation in the neutron sector. In particular, we show a CPT-violating see-saw mechanism, generating a Majorana mass and a CPT-violating mass for the neutron. CPT-violating see-saw involves a sterile partner of the neutron, living in a hidden sector, in which CPT is spontaneously broken. In particular, neutrons (antineutrons) can communicate with the hidden sector through nonperturbative quantum gravity effects called exotic instantons. Exotic instantons dynamically break R-parity, generating one effective vertex between the neutron and its sterile partner. In this way, we show how a small CPT-violating mass term for the neutron is naturally generated. This model can be tested in the next generation of experiments in neutron-antineutron physics. This strongly motivates researches of CPT-violating effects in neutron-antineutron physics as a test-bed for dynamical CPT-violations in SM.

  19. Novel pharmacotherapeutic strategies for treatment of opioid-induced neonatal abstinence syndrome

    PubMed Central

    McLemore, Gabrielle L.; Lewis, Tamorah; Jones, Catherine H.; Gauda, Estelle B.

    2014-01-01

    Summary The non-medical use of prescription drugs, in general, and opioids, in particular, is a national epidemic, resulting in enormous addiction rates, healthcare expenditures, and overdose deaths. Prescription opioids are overly prescribed, illegally trafficked, and frequently abused, all of which have created a new opioid addiction pathway, adding to the number of opioid-dependent newborns requiring treatment for neonatal abstinence syndrome (NAS), and contributing to challenges in effective care in maternal and fetal/neonatal (M-F/N) medicine. The standard of care for illicit or prescription opioid dependence during pregnancy is opioid agonist (methadone or buprenorphine) substitution therapy, which are also frequently abused. The next generation of pharmacotherapies for the treatment of illicit or prescription opioid addiction in the M-F/N interactional dyad must take into consideration the interplay between genetic, epigenetic, and environmental factors. Addiction to illicit drugs during pregnancy presents unique challenges to effectively treat the mother, and the developing fetus and infant after delivery. New pharmacotherapies should be safe to the developing fetus, effective in treating the physical and psychological consequences of addiction in the mother, and reduce the incidence and severity of NAS in the infant after birth. More pharmacotherapeutic options should be available to the physician such that a more individualized rather than a one-drug/strategy-fits-all approach can be used. A myriad of new and exciting pharmacotherapeutic strategies for the treatment of opioid dependence and addiction are on the horizon. This review focuses on such three strategies: (i) pharmacotherapeutic targeting of the serotoninergic system; (ii) mixed opioid immunotherapeutics (vaccines); (iii) pharmacogenomics as a therapeutic strategy to insure personalized care. We review and discuss how these strategies may offer additional treatment modalities for the treatment

  20. Neurotrophic factors in women with crack cocaine dependence during early abstinence: the role of early life stress

    PubMed Central

    Viola, Thiago Wendt; Tractenberg, Saulo Gantes; Levandowski, Mateus Luz; Pezzi, Júlio Carlos; Bauer, Moisés Evandro; Teixeira, Antonio Lúcio; Grassi-Oliveira, Rodrigo

    2014-01-01

    Background Neurotrophic factors have been investigated in the pathophysiology of alcohol and drug dependence and have been related to early life stress driving developmental programming of neuroendocrine systems. Methods We conducted a follow-up study that aimed to assess the plasma levels of glial cell line–derived neurotrophic factor (GDNF), brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), neurotrophin-3 (NT3) and neurotrophin-4/5 (NT4/5) in crack users during 3 weeks of early abstinence in comparison with healthy controls. We performed a comprehensive clinical assessment in female inpatients with crack cocaine dependence (separated into 2 groups: participants with (CSA+) and without (CSA−) a history of childhood sexual abuse) and a group of nonuser control participants. Results Our sample included 104 women with crack cocaine dependence and 22 controls; of the women who used crack cocaine, 22 had a history of childhood sexual abuse and 82 did not. The GDNF plasma levels in the CSA+ group increased dramatically during 3 weeks of detoxification. In contrast, those in the CSA− group showed lower and stable levels of GDNF under the same conditions. Compared with the control group, BDNF plasma levels remained elevated and NGF levels were reduced during early abstinence. We found no differences in NT3 and NT4/5 between the patients and controls. However, within-group analyses showed that the CSA+ group exhibited higher levels of NT4/5 than the CSA− group at the end of detoxification. Limitations Some of the participants were using neuroleptics, mood stabilizers or antidepressants; our sample included only women; memory bias could not be controlled; and we did not investigate the possible confounding effects of other forms of stress during childhood. Conclusion This study supports the association between early life stress and peripheral neurotrophic factor levels in crack cocaine users. During early abstinence, plasmastic GDNF and NT4/5 were

  1. Hadronic parity violation in few-body systems

    SciTech Connect

    L. Girlanda, R. Schiavilla, M. Viviani, A. Kievsky, L.E. Marcucci

    2009-06-01

    Recent interest, both from experimental and theoretical point of view, on hadronic parity violation is reviewed, with particular emphasis on an effective theory description. After discussing the minimal form of the parity-violating NN contact e ective Lagrangian, we concentrate on the calculation of the neutron spin rotation in vec n - d scattering at zero energy. We find that this observable is sensitive to the long-range component of the parity-violating NN pontential due to the pion exchange, and that it is expected to be one order of magnitude larger than in vec n - p scattering.

  2. Anxiety sensitivity: Concurrent associations with negative affect smoking motives and abstinence self-confidence among young adult smokers.

    PubMed

    Zvolensky, Michael J; Bonn-Miller, Marcel O; Feldner, Matthew T; Leen-Feldner, Ellen; McLeish, Alison C; Gregor, Kristin

    2006-03-01

    The present study evaluated the association between the lower-order facets of Anxiety Sensitivity construct (Physical, Mental Incapacitation and Social Concerns) and theoretically relevant cognitive-based smoking processes. Participants were 151 young adult daily smokers (63 females); mean number of cigarettes/day = 12.3 [S.D. = 5.6]). Both AS Physical and Mental Incapacitation Concerns were significantly associated with greater negative affect reduction smoking motives and lower levels of self-confidence in remaining abstinent from smoking when emotionally distressed. The observed effects were over and above the variance accounted for by nicotine dependence, smoking rate, and gender. Results are discussed in relation to better understanding cognitive-based smoking processes among individuals at heightened risk for panic psychopathology. PMID:15964151

  3. A Deposit Contract Method to Deliver Abstinence Reinforcement for Cigarette Smoking

    ERIC Educational Resources Information Center

    Dallery, Jesse; Meredith, Steven; Glenn, Irene M.

    2008-01-01

    Eight smokers were randomly assigned to a deposit contract ($50.00) or to a no-deposit group. Using a reversal design, participants could recoup their deposit (deposit group) or earn vouchers (no-deposit group) for smoking reductions and abstinence (breath carbon monoxide [CO] less than or equal to 4 parts per million) during treatment phases.…

  4. Government Influence and Community Involvement on Abstinence-Only Programs in 1999 and 2003

    ERIC Educational Resources Information Center

    Gusrang, Jamie L.; Cheng, Simon

    2010-01-01

    In this study, we compare federal government influence on abstinence-only programs in 1999 and 2003 to better see how shifts in the federal government's sex education polices impacted other government and community actors. Using data from the Sex Education in America Surveys (SEAS), we find that changes in federal policy, particularly after the…

  5. Hippocampal volume reduction in female but not male recent abstinent methamphetamine users.

    PubMed

    Du, Jiang; Quan, Meina; Zhuang, Wenxu; Zhong, Na; Jiang, Haifeng; Kennedy, David N; Harrington, Amy; Ziedonis, Douglas; Fan, Xiaoduo; Zhao, Min

    2015-08-01

    Growing evidence suggests abnormalities in brain morphology including hippocampal structure in patients with methamphetamine (MA) dependence. This study was performed to examine hippocampal volume in abstinent MA users, and to further explore its relationship with cognitive function. 30 abstinent MA users (20 males and 10 females) with average 5.52 months of duration of abstinence and 29 healthy controls (19 males and 10 females) age 18-45 years old were recruited for clinical assessment and imaging scan. FreeSurfer was used to segment the hippocampus bilaterally, and hippocampal volumes were extracted for group and gender comparisons. Cognitive function was measured using the CogState Battery Chinese language version (CSB-C). Analysis of covariance (ANCOVA) controlling for education showed a significant group by gender interaction for the right hippocampal relative volume adjusted for total brain size (p = 0.020); there was a significant difference between male controls and female controls (p < 0.001), but such a difference did not exist between male patients and female patients (p = 0.203). No significant correlations were found between hippocampal volume and cognitive measures. There seems to be a gender difference in how MA affects hippocampal volume in abstinent MA users. Hippocampus might be an important treatment target for cognitive improvement and functional recovery in this patient population, especially in females. PMID:25920682

  6. Teacher Perspectives on Abstinence and Safe Sex Education in South Africa

    ERIC Educational Resources Information Center

    Francis, Dennis A.; DePalma, Renée

    2014-01-01

    The stakes are high for sex education in South Africa: it has been estimated that 8.7% of young people live with HIV. Within primarily US and UK contexts, there has been much debate over the relative merits of abstinence-only and comprehensive sexual education programmes. These perspectives have largely been presented as irreconcilable, but…

  7. Making sense of abstinence: social representations in young Africans' HIV-related narratives from six countries.

    PubMed

    Winskell, Kate; Beres, Laura K; Hill, Elizabeth; Mbakwem, Benjamin Chigozie; Obyerodhyambo, Oby

    2011-09-01

    Despite the prominence of abstinence promotion in HIV prevention for young Africans, there is little documentation concerning its reception and interpretation. With the purpose of informing programmatic practice, we examined how young Africans from six countries with contrasting HIV prevalence rates make sense of abstinence. 'Scenarios from Africa' scriptwriting contests invite young people to contribute ideas for short films about HIV. Using thematic narrative-based approaches, we analyzed a stratified random sample of these narratives written in 2005 by young women and men aged 10-24 years from Senegal, Burkina Faso, South-East Nigeria, Kenya, Namibia and Swaziland. Abstinence was considerably more prominent as a theme in the samples from SE Nigeria, Kenya and Swaziland. It was articulated in relation to conservative Christian sexual morality and in opposition to condom use with particular intensity in SE Nigeria, with stigmatising implications for non-abstainers. However, cross-national commonalities were more striking than differences. Examples of non-stigmatising pro-abstinence messaging highlighted the appeal of discourses of romantic love and future plans across countries and demographic characteristics. The analysis yielded contextual understanding, youth-driven ideas and recommendations to inform comprehensive HIV-prevention efforts. PMID:21787256

  8. Associations between University Students' Reported Reasons for Abstinence from Illicit Substances and Type of Drug

    ERIC Educational Resources Information Center

    Rosenberg, Harold; Bonar, Erin E.; Pavlick, Michelle; Jones, Lance D.; Hoffmann, Erica; Murray, Shanna; Faigin, Carol Ann; Cabral, Kyle; Baylen, Chelsea

    2012-01-01

    We recruited 211 undergraduates to rate the degree to which each of 34 listed reasons for not taking drugs had influenced their abstinence from MDMA/ecstasy, cocaine, marijuana, and hallucinogens. Participants rated reasons such as personal and family medical histories, religion, and physiological consequences of drug use as having little or no…

  9. Sexual Partners and Contraceptive Use: A 16-Year Prospective Study Predicting Abstinence and Risk Behavior

    ERIC Educational Resources Information Center

    Siebenbruner, Jessica; Zimmer-Gembeck, Melanie J.; Egeland, Byron

    2007-01-01

    Antecedents and correlates of sexual behavior among 167 (46 female) adolescents were examined in this multi-informant longitudinal study. Data were collected at birth through middle adolescence. Data on number of sexual partners and contraception use at age 16 defined sexual abstinence (SAs, n = 73), high-risk sexual behavior (HRTs, n = 45) and…

  10. Resting state synchrony in long-term abstinent alcoholics with versus without comorbid drug dependence☆

    PubMed Central

    Camchong, Jazmin; Stenger, Victor Andrew; Fein, George

    2013-01-01

    Background We previously reported that when long-term abstinent alcoholics (LTAA; with no drug comorbidity) are compared to controls, they show increased resting state synchrony (RSS) in the executive control network and reduced RSS in the appetitive drive network suggestive of compensatory mechanisms that may facilitate abstinence. The aim of the present study was to investigate whether long-term abstinent alcoholics with comorbid stimulants dependence (LTAAS) show similar RSS mechanisms. Methods Resting-state functional MRI data were collected on 36 LTAAS (20 females, age: 47.85 ± 7.30), 23 LTAA (8 females, age: M = 47.91 ± 6.76), and 23 non-substance abusing controls (NSAC; 8 females, age: M = 47.99 ± 6.70). Using seed-based measures, we examined RSS with the nucleus accumbens (NAcc) and the subgenual anterior cingulate cortex (sgACC). Results Results showed commonalities in LTAA and LTAAS RSS (similar enhanced executive control RSS and left insula RSS) as well as differences (no attenuation of appetitive drive RSS in LTAAS and no enhancement of RSS in right insula in LTAA). Conclusions We believe these differences are adaptive mechanisms that support abstinence. These findings suggest common as well as specific targets for treatment in chronic alcoholics with vs without comorbid stimulant dependence. PMID:23639390

  11. Impacts of Four Title V, Section 510 Abstinence Education Programs. Final Report

    ERIC Educational Resources Information Center

    Trenholm, Christopher; Devaney, Barbara; Fortson, Ken; Quay, Ken; Wheeler, Justin; Clark, Melissa

    2007-01-01

    Since fiscal year 1998, the Title V, Section 510 program has allocated $50 million annually in federal funding for programs that teach abstinence form sexual activity outside of marriage as the expected standard for school-age children. A new impact report from Mathematica's congressionally mandated multi-year evaluation of four abstinence…

  12. Implementing and Evaluating a Rural Community-Based Sexual Abstinence Program: Challenges and Solutions

    ERIC Educational Resources Information Center

    Stauss, Kimberly; Boyas, Javier; Murphy-Erby, Yvette

    2012-01-01

    Informing both program evaluation and practice research, this paper describes lessons learned during the planning, implementation, and pilot phases of an abstinence education program based in a rural community in a southern state in the USA. Although a number of challenges can emerge in successfully implementing and evaluating such a program in a…

  13. An Evaluation of an Abstinence-Only Sex Education Curriculum: An 18-Month Follow-Up

    ERIC Educational Resources Information Center

    Denny, George; Young, Michael

    2006-01-01

    The article examines the results from an 18-month follow-up evaluation of an abstinence education curriculum series. Participants were students from 15 school districts recruited to participate in the project. The intervention was the Sex Can Wait curriculum series, consisting of upper elementary, middle school, and high school components. The…

  14. Evaluation of an Abstinence-Only Adolescent Pregnancy Prevention Program: A Replication.

    ERIC Educational Resources Information Center

    Roosa, Mark W.; Christopher, F. Scott

    1990-01-01

    Second evaluation of abstinence-only adolescent pregnancy prevention program included 528 subjects. None of desired changes in attitudes or behavior (premarital sexual attitudes, sexual behaviors, self-esteem, family communication) occurred for total sample or for virgins in sample. Findings question federal policy of relying exclusively on…

  15. Differential Transitions between Cocaine Use and Abstinence for Men and Women

    ERIC Educational Resources Information Center

    Gallop, Robert J.; Crits-Christoph, Paul; Ten Have, Thomas R.; Barber, Jacques P.; Frank, Arlene; Griffin, Margaret L.; Thase, Michael E.

    2007-01-01

    The longitudinal course of cocaine dependence is characterized by alternating periods of abstinence and relapse. Although gender has emerged as an important predictor of relapse, previous studies have examined mean differences in use by gender. Focusing strictly on differences in averages between men and women does not address potential gender…

  16. Motivational interviewing group at inpatient detoxification, its influence in maintaining abstinence and treatment retention after discharge.

    PubMed

    Bachiller, Diana; Grau-López, Lara; Barral, Carmen; Daigre, Constanza; Alberich, Cristina; Rodríguez-Cintas, Laia; Valero, Sergi; Casas, Miquel; Roncero, Carlos

    2015-01-01

    The relapse rate after discharge from inpatient detoxification is high. The objective of this pilot study is to assess the sociodemographic, clinical and therapeutic factors associated with maintaining abstinence in patients who participated in a brief motivational interviewing group during admission for detoxification. A total of 46 patients, diagnosed substance dependent according to DSM -IV, and admitted to the Hospital Detoxification Unit, participated in a brief motivational interviewing group. Sociodemographic, clinical, motivation to change (University of Rhode Island Change Assessment, URICA) and satisfaction with the treatment group (Treatment Perceptions Questionnaire, CPT) data were collected. Abstinence and treatment retention two months after discharge were assessed by weekly telephone calls. A survival analysis was performed. Being male, having more cognitions of the maintenance stage of change at discharge, being satisfied with group therapy and therapist during hospitalization are associated with longer abstinence after discharge. The brief motivational interviewing group approach with patients admitted for detoxification is related to greater likelihood of maintaining abstinence and subsequent treatment retention. PMID:26132300

  17. Sex Can Wait: An Abstinence-Based Sexuality Curriculum for Upper Elementary School.

    ERIC Educational Resources Information Center

    Young, Michael; Young, Tamera

    This curriculum, directed primarily to students in grades five and six, is a 5-week sexuality education program designed to promote sexual abstinence as the best decision young people can make for themselves. The guide is divided into three general areas of emphasis: Knowing Myself, Reltating to Others, and Planning My Future. These sections are…

  18. Sex Can Wait: An Abstinence-Based Sexuality Curriculum for High School.

    ERIC Educational Resources Information Center

    Core-Gebhart, Pennie; And Others

    This curriculum, directed primarily to students in grades nine and ten, is a 5-week sexuality education program designed to promote sexual abstinence as the best decision young people can make for themselves. The guide is divided into four general areas of emphasis. Section one, "Knowing Myself," helps students feel good about who they are as…

  19. The Evaluation of Abstinence Education Programs Funded Under Title V Section 510: Interim Report.

    ERIC Educational Resources Information Center

    Devaney, Barbara; Johnson, Amy; Maynard, Rebecca; Trenholm, Chris

    This report presents interim findings from an independent, federally funded evaluation of the abstinence education programs authorized under the Personal Responsibility and Work Opportunity Reconciliation Act (PRWORA) and defined under Title V, Section 510 (b)(2)(A-H) of the Social Security Act. The report draws heavily on 4 years of…

  20. Adolescents' Thoughts about Abstinence Curb the Return of Marijuana Use during and after Treatment

    ERIC Educational Resources Information Center

    King, Kevin M.; Chung, Tammy; Maisto, Stephen A.

    2009-01-01

    Despite evidence showing that readiness to change substance use predicts reductions in substance use among treated adolescents, there is little research on changes in thoughts about abstinence and marijuana use during and after treatment. The current study tested whether time-varying changes in adolescents' motivation to abstain and perceived…

  1. Six month abstinence rule for liver transplantation in severe alcoholic liver disease patients

    PubMed Central

    Obed, Aiman; Stern, Steffen; Jarrad, Anwar; Lorf, Thomas

    2015-01-01

    Alcoholic liver disease (ALD) is the second most common diagnosis among patients undergoing liver transplantation (LT). The recovery results of patients transplanted for ALD are often at least as good as those of patients transplanted for other diagnoses and better than those suffering from hepatitis C virus, cryptogenic cirrhosis, or hepatocellular carcinoma. In the case of medically non-responding patients with severe acute alcoholic hepatitis or acute-on chronic liver failure, the refusal of LT is often based on the lack of the required alcohol abstinence period of six months. The obligatory abidance of a period of abstinence as a transplant eligibility requirement for medically non-responding patients seems unfair and inhumane, since the majority of these patients will not survive the six-month abstinence period. Data from various studies have challenged the 6-mo rule, while excellent survival results of LT have been observed in selected patients with severe alcoholic hepatitis not responding to medical therapy. Patients with severe advanced ALD should have legal access to LT. The mere lack of pre-LT abstinence should not be an obstacle for being listed. PMID:25892898

  2. Experiences of violence and association with decreased drug abstinence among women in Cape Town, South Africa.

    PubMed

    Reed, Elizabeth; Myers, Bronwyn; Novak, Scott P; Browne, Felicia A; Wechsberg, Wendee M

    2015-01-01

    Drug abuse is a contributing factor in women's HIV risk in low-income communities in Cape Town, South Africa. This study assessed whether experiencing violence is associated with reduced drug abstinence among adult women (n = 603) participating in a randomized field trial for an HIV prevention study in Cape Town. In relation to drug abstinence at 12-month follow-up, multivariable regression models were used to assess (1) baseline partner and non-partner victimization, and (2) victimization at 12-month follow-up among participants reporting baseline victimization. Baseline partner (AOR = 0.6; 95 % CI 0.4-0.9) and non-partner victimization (AOR = 0.6; 95 % CI 0.4-0.9) were associated with a reduced likelihood of drug abstinence at follow-up. Among participants who reported victimization at baseline, those no longer reporting victimization at follow-up did not differ significantly in drug abstinence compared with those who reported victimization at follow-up. The study findings highlight the lasting impact of victimization on women's drug use outcomes, persisting regardless of whether violence was no longer reported at follow-up. Overall, the findings support the need for the primary prevention of violence to address the cycle of violence, drug use, and HIV among women in this setting. PMID:24934652

  3. Sex Can Wait: An Abstinence-Based Sexuality Curriculum for Middle School.

    ERIC Educational Resources Information Center

    Core-Gebhart, Pennie; And Others

    This curriculum, directed primarily to students in grades seven and eight, is a five-week sexuality education program designed to promote sexual abstinence as the best decision young people can make for themselves. The guide is divided into three general areas of emphasis. These sections are divided into six units that focus the content of the…

  4. Remaining Off Alcohol and Drugs: A Self-Management Skills Program for Abstinence.

    ERIC Educational Resources Information Center

    Dunphy, Peter Hughes

    The Remaining Off Alcohol and Drugs Program (ROAD) was developed to teach newly abstinent chemical misusing clients how to remain alcohol and drug free. It provides its participants with a repertoire of knowledge, skills and behaviors that they can use in dealing with the most common problems caused by discontinuing chemical use and which can be…

  5. Experiences of Violence and Association with Decreased Drug Abstinence Among Women in Cape Town, South Africa

    PubMed Central

    Reed, Elizabeth; Myers, Bronwyn; Novak, Scott P.; Browne, Felicia A.; Wechsberg, Wendee M.

    2015-01-01

    Drug abuse is a contributing factor in women’s HIV risk in low-income communities in Cape Town, South Africa. This study assessed whether experiencing violence is associated with reduced drug abstinence among adult women (n = 603) participating in a randomized field trial for an HIV prevention study in Cape Town. In relation to drug abstinence at 12-month follow-up, multivariable regression models were used to assess (1) baseline partner and non-partner victimization, and (2) victimization at 12-month follow-up among participants reporting baseline victimization. Baseline partner (AOR = 0.6; 95 % CI 0.4–0.9) and non-partner victimization (AOR = 0.6; 95 % CI 0.4–0.9) were associated with a reduced likelihood of drug abstinence at follow-up. Among participants who reported victimization at baseline, those no longer reporting victimization at follow-up did not differ significantly in drug abstinence compared with those who reported victimization at follow-up. The study findings highlight the lasting impact of victimization on women’s drug use outcomes, persisting regardless of whether violence was no longer reported at follow-up. Overall, the findings support the need for the primary prevention of violence to address the cycle of violence, drug use, and HIV among women in this setting. PMID:24934652

  6. Voucher-Based Contingent Reinforcement of Smoking Abstinence among Methadone-Maintained Patients: A Pilot Study

    ERIC Educational Resources Information Center

    Dunn, Kelly E.; Sigmon, Stacey C.; Thomas, Colleen S.; Heil, Sarah H.; Higgins, Stephen T.

    2008-01-01

    This study evaluated the efficacy of a contingency management (CM) intervention to promote smoking cessation in methadone-maintained patients. Twenty participants, randomized into contingent (n = 10) or noncontingent (n = 10) experimental conditions, completed the 14-day study. Abstinence was determined using breath carbon monoxide and urine…

  7. Unraveling duality violations in hadronic tau decays

    SciTech Connect

    Cata, Oscar; Cata, Oscar; Golterman, Maarten; Peris, Santiago

    2008-03-03

    There are some indications from recent determinations of the strong coupling constant alpha_s and the gluon condensate that the Operator Product Expansion may not be accurate enough to describe non-perturbative effects in hadronic tau decays. This breakdown of the Operator Product Expansion is usually referred to as being due to"Duality Violations." With the help of a physically motivated model, we investigate these duality violations. Based on this model, we argue how they may introduce a non-negligible systematic error in the current analysis, which employs finite-energy sum rules with pinched weights. In particular, this systematic effect might affect the precision determination of alpha_s from tau decays. With a view to a possible future application to real data, we present an alternative method for determining the OPE coefficients that might help estimating, and possibly even reducing, this systematic error.

  8. Lepton flavor violating decays of vector mesons

    SciTech Connect

    Gutsche, Thomas; Lyubovitskij, Valery E.; Helo, Juan C.; Kovalenko, Sergey

    2010-02-01

    We estimate the rates of lepton flavor violating decays of the vector mesons {rho}, {omega}, and {phi}{yields}e{mu}. The theoretical tools are based on an effective Lagrangian approach without referring to any specific realization of the physics beyond the standard model responsible for lepton flavor violation (Le{sub f}). The effective lepton-vector meson couplings are extracted from the existing experimental bounds on the nuclear {mu}{sup -}-e{sup -} conversion. In particular, we derive an upper limit for the Le{sub f} branching ratio Br({phi}{yields}e{mu}){<=}1.3x10{sup -21} which is much more stringent than the recent experimental result Br({phi}{yields}e{mu})<2x10{sup -6} presented by the SND Collaboration. Very tiny limits on Le{sub f} decays of vector mesons derived in this paper make direct experimental observation of these processes unrealistic.

  9. Methamphetamine abstinence induces changes in μ-opioid receptor, oxytocin and CRF systems: Association with an anxiogenic phenotype.

    PubMed

    Georgiou, Polymnia; Zanos, Panos; Garcia-Carmona, Juan-Antonio; Hourani, Susanna; Kitchen, Ian; Laorden, Maria-Luisa; Bailey, Alexis

    2016-06-01

    The major challenge in treating methamphetamine addicts is the maintenance of a drug free-state since they experience negative emotional symptoms during abstinence, which may trigger relapse. The neuronal mechanisms underlying long-term withdrawal and relapse are currently not well-understood. There is evidence suggesting a role of the oxytocin (OTR), μ-opioid receptor (MOPr), dopamine D2 receptor (D2R), corticotropin-releasing factor (CRF) systems and the hypothalamic-pituitary-adrenal (HPA)-axis in the different stages of methamphetamine addiction. In this study, we aimed to characterize the behavioral effects of methamphetamine withdrawal in mice and to assess the modulation of the OTR, MOPr, D2R, CRF and HPA-axis following chronic methamphetamine administration and withdrawal. Ten-day methamphetamine administration (2 mg/kg) increased OTR binding in the amygdala, whilst 7 days of withdrawal induced an upregulation of this receptor in the lateral septum. Chronic methamphetamine treatment increased plasma OT levels that returned to control levels following withdrawal. In addition, methamphetamine administration and withdrawal increased striatal MOPr binding, as well as c-Fos(+)/CRF(+) neuronal expression in the amygdala, whereas an increase in plasma corticosterone levels was observed following METH administration, but not withdrawal. No differences were observed in the D2R binding following METH administration and withdrawal. The alterations in the OTR, MOPr and CRF systems occurred concomitantly with the emergence of anxiety-related symptoms and the development of psychomotor sensitization during withdrawal. Collectively, our findings indicate that chronic methamphetamine use and abstinence can induce brain-region specific neuroadaptations of the OTR, MOPr and CRF systems, which may, at least, partly explain the withdrawal-related anxiogenic effects. PMID:26896754

  10. Repeated transcranial direct current stimulation prevents abnormal behaviors associated with abstinence from chronic nicotine consumption.

    PubMed

    Pedron, Solène; Monnin, Julie; Haffen, Emmanuel; Sechter, Daniel; Van Waes, Vincent

    2014-03-01

    Successful available treatments to quit smoking remain scarce. Recently, the potential of transcranial direct current stimulation (tDCS) as a tool to reduce craving for nicotine has gained interest. However, there is no documented animal model to assess the neurobiological mechanisms of tDCS on addiction-related behaviors. To address this topic, we have developed a model of repeated tDCS in mice and used it to validate its effectiveness in relieving nicotine addiction. Anodal repeated tDCS was applied over the frontal cortex of Swiss female mice. The stimulation electrode (anode) was fixed directly onto the cranium, and the reference electrode was placed onto the ventral thorax. A 2 × 20 min/day stimulation paradigm for five consecutive days was used (0.2 mA). In the first study, we screened for behaviors altered by the stimulation. Second, we tested whether tDCS could alleviate abnormal behaviors associated with abstinence from nicotine consumption. In naive animals, repeated tDCS had antidepressant-like properties 3 weeks after the last stimulation, improved working memory, and decreased conditioned place preference for nicotine without affecting locomotor activity and anxiety-related behavior. Importantly, abnormal behaviors associated with chronic nicotine exposure (ie, depression-like behavior, increase in nicotine-induced place preference) were normalized by repeated tDCS. Our data show for the first time in an animal model that repeated tDCS is a promising, non-expensive clinical tool that could be used to reduce smoking craving and facilitate smoking cessation. Our animal model will be useful to investigate the mechanisms underlying the effects of tDCS on addiction and other psychiatric disorders. PMID:24154668

  11. Isospin violation in pion-kaon scattering

    NASA Astrophysics Data System (ADS)

    Kubis, Bastian; Meißner, Ulf-G.

    2002-03-01

    We consider strong and electromagnetic isospin violation in near-threshold pion-kaon scattering. At tree level, such effects are small for all physical channels. We work out the complete one-loop corrections to the process π-K +→ π0K 0. They come out rather small. We also show that the corresponding radiative cross section is highly suppressed at threshold.

  12. Dysregulated responses to emotions among abstinent heroin users: correlation with childhood neglect and addiction severity.

    PubMed

    Gerra, G; Somaini, L; Manfredini, M; Raggi, M A; Saracino, M A; Amore, M; Leonardi, C; Cortese, E; Donnini, C

    2014-01-01

    The aim of this paper was to investigate the subjective responses of abstinent heroin users to both neutral and negative stimuli and the related hypothalamus-pituitary-adrenal reactions to emotional experience in relationship to their perception of childhood adverse experiences. Thirty male abstinent heroin dependents were included in the study. Emotional responses and childhood neglect perception were measured utilizing the State-Trait Anxiety Inventory Y-1 and the Child Experience of Care and Abuse Questionnaire. Neutral and unpleasant pictures selected from the International Affective Picture System and the Self-Assessment Manikin procedure have been used to determine ratings of pleasure and arousal. These ratings were compared with normative values obtained from healthy volunteers used as control. Blood samples were collected before and after the experimental sessions to determine both adrenocorticotropic hormone and cortisol plasma levels. Basal anxiety scores, cortisol and adrenocorticotropic hormone levels were higher in abstinent heroin users than in controls. Tests showed that anxiety scores did not change in controls after the vision of neutral slides, whilst they did in abstinent heroin addicts, increasing significantly; and increased less significantly after the unpleasant task, in comparison to controls. Abstinent heroin users showed significantly higher levels of parent antipathy and childhood emotional neglect perception than controls for both the father and the mother. Plasma adrenocorticotropic hormone and cortisol levels did not significantly increase after unpleasant slide set viewing among addicted individuals, because of the significantly higher basal levels characterizing the addicted subjects in comparison with controls. Multiple regression correlation showed a significant relationship between childhood neglect perception, arousal reaction, impaired hypothalamus-pituitary-adrenal axis response and addiction severity. Early adverse experiences

  13. Rapid Recovery of Vesicular Dopamine Levels in Methamphetamine Users in Early Abstinence.

    PubMed

    Boileau, Isabelle; McCluskey, Tina; Tong, Junchao; Furukawa, Yoshiaki; Houle, Sylvain; Kish, Stephen J

    2016-03-01

    We previously reported very low levels of dopamine in post-mortem striatum of chronic methamphetamine users, raising the possibility that restoration of normal dopamine levels could help in this addiction and perhaps prevent early relapse. To establish relevance of this finding to the living brain, we tested whether striatal [(11)C]-(+)-dihydrotetrabenazine binding, a vesicular monoamine transporter probe sensitive to changes in (stored) vesicular dopamine, is elevated in methamphetamine users. Chronic methamphetamine users underwent [(11)C]-(+)-dihydrotetrabenazine positron emission tomography scans during early (mean 2.6 days) and later (~10 days) abstinence. Striatal [(11)C]-(+)-dihydrotetrabenazine binding was elevated (suggesting low stored dopamine) in methamphetamine users (n=28; 2.6 days after last use) relative to controls (n=22) (+28%, p<0.0001) and correlated with severity and recency of drug use and with cognitive impairment and withdrawal symptoms. Mean [(11)C]-(+)-dihydrotetrabenazine binding levels in the subgroup of methamphetamine users who could remain abstinent ~10 days following last use (n=17) were normal at the follow-up scan. Our imaging data support post-mortem findings and suggest that chronic methamphetamine users have low brain levels of stored dopamine during very early abstinence from MA, which could contribute to behavioral and cognitive deficits. Findings also suggest a rapid recovery of stored dopamine in some methamphetamine users who become abstinent and who therefore might not benefit from dopamine replacement medication (eg, levodopa). Further study is necessary to establish whether those users who could not maintain abstinence for the second scan might have a more severe and persistent dopamine deficiency and who could benefit from this medication. PMID:26321315

  14. Gravity from Lorentz Symmetry Violation

    SciTech Connect

    Potting, Robertus

    2006-06-19

    In general relativity, the masslessness of gravitons can be traced to symmetry under diffeomorphisms. In this talk, we consider another possibility, whereby the masslessness arises from spontaneous violation of Lorentz symmetry.

  15. Quark model and CP violation

    NASA Astrophysics Data System (ADS)

    Kobayashi, Makoto

    2014-11-01

    After a short review of the activities of Shoichi Sakata and his group, how the six-quark model explains CP violation is described. Experimental verification of the model at the B-factories is also briefly discussed.

  16. 7 CFR 632.42 - Violation procedures.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... conservationist, that a violation did not occur or that the violation was of such a nature that no penalty of... refused. (2) The notice setting forth the nature of the alleged violation is to give the land user an... decision is to state whether the violation is of such a nature as to warrant termination of the...

  17. CPT violation and B-meson oscillations

    SciTech Connect

    Kostelecky, V. Alan; Van Kooten, Richard J.

    2010-11-15

    Recent evidence for anomalous CP violation in B-meson oscillations can be interpreted as resulting from CPT violation. This yields the first sensitivity to CPT violation in the B{sub s}{sup 0} system, with the relevant coefficient for CPT violation constrained at the level of parts in 10{sup 12}.

  18. Speeded Recognition of Ungrammaticality: Double Violations.

    ERIC Educational Resources Information Center

    Moore, Timothy E.; Biederman, Irving

    1979-01-01

    The speed at which sentences with various kinds of violations could be rejected was studied. Compatible with the sequential model was the finding that noun-verb and adjective-noun double violations did not result in shorter reaction times than noun-verb single violations, although double violations were judged less acceptable. (Author/RD)

  19. Causality violation, gravitational shockwaves and UV completion

    NASA Astrophysics Data System (ADS)

    Hollowood, Timothy J.; Shore, Graham M.

    2016-03-01

    The effective actions describing the low-energy dynamics of QFTs involving gravity generically exhibit causality violations. These may take the form of superluminal propagation or Shapiro time advances and allow the construction of "time machines", i.e. spacetimes admitting closed non-spacelike curves. Here, we discuss critically whether such causality violations may be used as a criterion to identify unphysical effective actions or whether, and how, causality problems may be resolved by embedding the action in a fundamental, UV complete QFT. We study in detail the case of photon scattering in an Aichelburg-Sexl gravitational shockwave background and calculate the phase shifts in QED for all energies, demonstrating their smooth interpolation from the causality-violating effective action values at low-energy to their manifestly causal high-energy limits. At low energies, these phase shifts may be interpreted as backwards-in-time coordinate jumps as the photon encounters the shock wavefront, and we illustrate how the resulting causality problems emerge and are resolved in a two-shockwave time machine scenario. The implications of our results for ultra-high (Planck) energy scattering, in which graviton exchange is modelled by the shockwave background, are highlighted.

  20. Time-reversal violation in beta decay

    SciTech Connect

    Herczeg, P.

    2003-01-01

    At present there is no unambigous direct evidence for time-reversal (T) violation in the fundamental interactions. But T-violation is intimately connected with CP-violation by the CPT theorem. A stringent bound on possible violation of CPT invariance comes from the properties of K{sup 0} - {bar K}{sup 0} mixing [I]. In the following we shall assume that CPT violating interactions, if present, can be neglected, and use the terms 'T-violation' and 'CP-violation' interchangably.

  1. Abstinence from Cocaine and Sucrose Self-Administration Reveals Altered Mesocorticolimbic Circuit Connectivity by Resting State MRI

    PubMed Central

    Lu, Hanbing; Zou, Qihong; Chefer, Svetlana; Ross, Thomas J.; Vaupel, D. Bruce; Guillem, Karine; Rea, William P.; Yang, Yihong; Peoples, Laura L.

    2014-01-01

    Abstract Previous preclinical studies have emphasized that drugs of abuse, through actions within and between mesocorticolimbic (MCL) regions, usurp learning and memory processes normally involved in the pursuit of natural rewards. To distinguish MCL circuit pathobiological neuroadaptations that accompany addiction from general learning processes associated with natural reward, we trained two groups of rats to self-administer either cocaine (IV) or sucrose (orally) followed by an identically enforced 30 day abstinence period. These procedures are known to induce behavioral changes and neuroadaptations. A third group of sedentary animals served as a negative control group for general handling effects. We examined low-frequency spontaneous fluctuations in the functional magnetic resonance imaging (fMRI) signal, known as resting-state functional connectivity (rsFC), as a measure of intrinsic neurobiological interactions between brain regions. Decreased rsFC was seen in the cocaine-SA compared with both sucrose-SA and housing control groups between prelimbic (PrL) cortex and entopeduncular nucleus and between nucleus accumbens core (AcbC) and dorsomedial prefrontal cortex (dmPFC). Moreover, individual differences in cocaine SA escalation predicted connectivity strength only in the Acb-dmPFC circuit. These data provide evidence of fronto-striatal plasticity across the addiction trajectory, which are consistent with Acb-PFC hypoactivity seen in abstinent human drug addicts, indicating potential circuit level biomarkers that may inform therapeutic interventions. They further suggest that available data from cross-sectional human studies may reflect the consequence of rather a predispositional predecessor to their dependence. PMID:24999822

  2. A role for the prefrontal cortex in heroin-seeking after forced abstinence by adult male rats but not adolescents.

    PubMed

    Doherty, James M; Cooke, Bradley M; Frantz, Kyle J

    2013-02-01

    Adolescent drug abuse is hypothesized to increase the risk of drug addiction. Yet male rats that self-administer heroin as adolescents show attenuated drug-seeking after abstinence, compared with adults. Here we explore a role for neural activity in the medial prefrontal cortex (mPFC) in age-dependent heroin-seeking. Adolescent (35-day-old at start; adolescent-onset) and adult (86-day-old at start) male rats acquired lever-pressing maintained by heroin using a fixed ratio one reinforcement schedule (0.05 and 0.025 mg/kg per infusion). Following 12 days of forced abstinence, rats were tested for heroin-seeking over 1 h by measuring the number of lever presses on the active lever. Unbiased stereology was then used to estimate the number of Fos-ir(+) and Fos-ir(-) neurons in prelimbic and infralimbic mPFC. As before, adolescents and adults self-administered similar amounts of heroin, but subsequent heroin-seeking was attenuated in the younger rats. Similarly, the adolescent-onset group failed to show significant neural activation in the prelimbic or infralimbic mPFC during the heroin-seeking test, whereas the adult-onset heroin self-administration group showed two to six times more Fos-ir(+) neurons than their saline counterparts in both mPFC subregions. Finally, the overall number of neurons in the infralimbic cortex was greater in rats from the adolescent-onset groups than adults. The mPFC may thus have a key role in some age-dependent effects of heroin self-administration. PMID:23072838

  3. A Role For The Prefrontal Cortex In Heroin-Seeking After Forced Abstinence By Adult Male Rats But Not Adolescents

    PubMed Central

    Doherty, James M; Cooke, Bradley M; Frantz, Kyle J

    2013-01-01

    Adolescent drug abuse is hypothesized to increase the risk of drug addiction. Yet male rats that self-administer heroin as adolescents show attenuated drug-seeking after abstinence, compared with adults. Here we explore a role for neural activity in the medial prefrontal cortex (mPFC) in age-dependent heroin-seeking. Adolescent (35-day-old at start; adolescent-onset) and adult (86-day-old at start) male rats acquired lever-pressing maintained by heroin using a fixed ratio one reinforcement schedule (0.05 and 0.025 mg/kg per infusion). Following 12 days of forced abstinence, rats were tested for heroin-seeking over 1 h by measuring the number of lever presses on the active lever. Unbiased stereology was then used to estimate the number of Fos-ir+ and Fos-ir− neurons in prelimbic and infralimbic mPFC. As before, adolescents and adults self-administered similar amounts of heroin, but subsequent heroin-seeking was attenuated in the younger rats. Similarly, the adolescent-onset group failed to show significant neural activation in the prelimbic or infralimbic mPFC during the heroin-seeking test, whereas the adult-onset heroin self-administration group showed two to six times more Fos-ir+ neurons than their saline counterparts in both mPFC subregions. Finally, the overall number of neurons in the infralimbic cortex was greater in rats from the adolescent-onset groups than adults. The mPFC may thus have a key role in some age-dependent effects of heroin self-administration. PMID:23072838

  4. Lifetime and Current Mood and Anxiety Disorders in Short-Term and Long-Term Abstinent Alcoholics

    PubMed Central

    Fein, George

    2013-01-01

    BACKGROUND A high prevalence of comorbid mood and anxiety disorders has been demonstrated in alcoholics. We examined lifetime and current mood and anxiety diagnoses and symptoms in long-term (mean 7.6 years; n = 110) and short-term (mean 10.1 weeks; n = 101) abstinent alcoholics (LTAA and STAA) and non substance abusing controls (NSAC; n = 82). All alcoholics met DSM-IV lifetime alcohol dependence criteria. About half of each alcoholic group had lifetime drug dependence. METHODS Alcohol use was assessed using timeline follow-back methodology and drug and alcohol use disorders were diagnosed using the AUDADIS-IV. Lifetime and current mood and anxiety disorder diagnoses and symptom counts were gathered using the c-DIS. RESULTS Over 60% of STAA and LTAA had a lifetime internalizing diagnosis vs. about 15% of NSAC, with no difference between STAA and LTAA. The Group effect on lifetime diagnoses was independent of comorbid drug dependence or gender and was of comparable size for mood and anxiety disorders. Current diagnoses showed a similar pattern, except that STAA had more current mood diagnoses than LTAA. Excluding individuals with lifetime internalizing diagnoses, alcoholics still had more mood and anxiety symptoms than controls. CONCLUSIONS 1) The presence of a lifetime mood or anxiety diagnosis or of a current anxiety diagnosis did not differ between STAA and LTAA, suggesting that such diagnoses do not impact one’s ability to achieve or maintain abstinence. 2) Prevalence of mood and anxiety diagnoses were unaffected by presence of a comorbid substance use disorder, and 3) excluding individuals with a mood or anxiety diagnosis does not eliminate mood and anxiety symptom count differences between groups. PMID:23895247

  5. Polarized electron scattering, new physics and dark parity violation

    SciTech Connect

    Marciano, William J.

    2013-11-07

    'New Physics' sensitivities of polarized electron scattering asymmetries, atomic parity violation, m{sub W} and sin{sup 2} θ{sub W} (Z pole measurements) are compared. The utility of low Q{sup 2} polarized electron scattering for probing parity violating 'dark boson' effects is discussed. A possible determination of the weak charge Q{sub w}({sup 12}C) to about ±0.3% via elastic e-Carbon scattering is advocated.

  6. Seeking CP violating couplings in ZZ production at LEP2

    NASA Astrophysics Data System (ADS)

    Biebel, Jochen

    1998-02-01

    The effects of CP violating anomalous ZZZ and γZZ vertices in ZZ production are determined. We present the differential cross-section for e+e--->ZZ with dependence on the spins of the Z bosons. It is shown that from the different spin combinations those with one longitudinally and one transversally polarized Z in the final state are the most sensitive to CP violating anomalous couplings.

  7. Lorentz- and CPT-violating signals in Penning traps

    NASA Astrophysics Data System (ADS)

    Ding, Yunhua; Kostelecký, Alan

    2016-05-01

    CPT and Lorentz symmetries are fundamental properties of the Standard Model. However, violation of these symmetries is possible in an underlying unified theory such as strings. This talk will focus on possible experimental effects for Lorentz and CPT violations. In particular, observable signals in measurements of anomaly and cyclotron frequencies of particles and antiparticles in a Penning trap will be discussed. New constraints from existing data will be presented and prospective sensitivities in future experiments will be outlined.

  8. Limits on C P T violation from solar neutrinos

    NASA Astrophysics Data System (ADS)

    Díaz, Jorge S.; Schwetz, Thomas

    2016-05-01

    Violations of C P T invariance can induce neutrino-to-antineutrino transitions. We study this effect for solar neutrinos and use the upper bound on the solar neutrino-to-antineutrino transition probability from the KamLAND experiment to constrain C P T -symmetry-violating coefficients of the general Standard-Model Extension. The long propagation distance from the Sun to the Earth allows us to improve existing limits by factors ranging from about a thousand to 1011 .

  9. Increasing Incidence and Geographic Distribution of Neonatal Abstinence Syndrome: United States 2009-2012

    PubMed Central

    Patrick, Stephen W.; Davis, Matthew M.; Lehman, Christoph U.; Cooper, William O.

    2015-01-01

    Objective Neonatal abstinence syndrome (NAS), a postnatal opioid withdrawal syndrome, increased 3-fold from 2000 to 2009. Since 2009, opioid pain reliever prescriptions and complications increased markedly throughout the US. Understanding recent changes in NAS and its geographic variability would inform state and local governments in targeting public health responses. Study Design We utilized diagnostic and demographic data for hospital discharges from 2009 to 2012 from the Kids’ Inpatient Database and the Nationwide Inpatient Sample. NAS-associated diagnoses were identified utilizing ICD-9-CM codes. All analyses were conducted with nationally weighted data. Expenditure data were adjusted to 2012 US dollars. Between-year differences were determined utilizing least squares regression. Results From 2009 to 2012, NAS incidence increased nationally from 3.4 (95%CI: 3.2-3.6) to 5.8 (95%CI 5.5-6.1) per 1,000 hospital births, reaching a total of 21,732 infants with the diagnosis. Aggregate hospital charges for NAS increased from $732M to $1.5B (p<0.001), with 81% attributed to state Medicaid programs in 2012. NAS incidence varied by geographic Census division, with the highest incidence rate (per 1000 hospital births) of 16.2 (95%CI 12.4-18.9) in the East South Central Division (KY, TN, MS, AL) and the lowest in West South Central Division 2.6 (95%CI 2.3-2.9; [OK, TX, AR, LA]). Conclusion NAS incidence and hospital charges grew substantially during our study period. This costly public health problem merits a public health approach to alleviate harm to women and children. States, particularly in areas of the country most affected by the syndrome, must continue to pursue primary prevention strategies to limit the effects of opioid pain reliever misuse. PMID:25927272

  10. Attentional dysfunction in abstinent long-term cannabis users with and without schizophrenia.

    PubMed

    Rentzsch, Johannes; Stadtmann, Ada; Montag, Christiane; Kunte, Hagen; Plöckl, Doris; Hellweg, Rainer; Gallinat, Jürgen; Kronenberg, Golo; Jockers-Scherübl, Maria Christiane

    2016-08-01

    Long-term cannabis use may confer cognitive deficits and increased risk of psychosis. However, the relationship between cannabis use and schizophrenia is complex. In particular, little is known about the effects of chronic cannabis use on the attention-related electric brain response in schizophrenia. We investigated auditory novelty and oddball P300 evoked potentials in a mixed sample of first-episode and chronic schizophrenic patients and healthy controls with (SZCA, n = 20; COCA, n = 20, abstinence ≥28 days) or without (SZ, n = 20; CO, n = 20) chronic cannabis use. Duration of regular cannabis use was 8.3 ± 5.6 (SZCA) and 9.1 ± 7.1 (COCA) years. In general, schizophrenic patients showed reduced P300 amplitudes. Cannabis use was associated with both a reduced early and late left-hemispheric novelty P300. There was a significant 'diagnosis × cannabis' interaction for the left-hemispheric late novelty P300 in that cannabis use was associated with a reduced amplitude in the otherwise healthy but not in the schizophrenic group compared with their relative control groups (corrected p < 0.02; p > 0.9, respectively). The left-hemispheric late novelty P300 in the otherwise healthy cannabis group correlated inversely with amount and duration of cannabis use (r = -0.50, p = 0.024; r = -0.57, p = 0.009, respectively). Our study confirms attentional deficits with chronic cannabis use. However, cannabis use may lead to different cognitive sequelae in patients with schizophrenia and in healthy controls, possibly reflecting preexisting alterations in the endocannabinoid system in schizophrenia. PMID:26182894

  11. Infant and maternal characteristics in neonatal abstinence syndrome--selected hospitals in Florida, 2010-2011.

    PubMed

    Lind, Jennifer N; Petersen, Emily E; Lederer, Philip A; Phillips-Bell, Ghasi S; Perrine, Cria G; Li, Ruowei; Hudak, Mark; Correia, Jane A; Creanga, Andreea A; Sappenfield, William M; Curran, John; Blackmore, Carina; Watkins, Sharon M; Anjohrin, Suzanne

    2015-03-01

    Neonatal abstinence syndrome (NAS) is a constellation of physiologic and neurobehavioral signs exhibited by newborns exposed to addictive prescription or illicit drugs taken by a mother during pregnancy. The number of hospital discharges of newborns diagnosed with NAS has increased more than 10-fold (from 0.4 to 4.4 discharges per 1,000 live births) in Florida since 1995, far exceeding the three-fold increase observed nationally. In February 2014, the Florida Department of Health requested the assistance of CDC to 1) assess the accuracy and validity of using Florida's hospital inpatient discharge data, linked to birth and infant death certificates, as a means of NAS surveillance and 2) describe the characteristics of infants with NAS and their mothers. This report focuses only on objective two, describing maternal and infant characteristics in the 242 confirmed NAS cases identified in three Florida hospitals during a 2-year period (2010-2011). Infants with NAS experienced serious medical complications, with 97.1% being admitted to an intensive care unit, and had prolonged hospital stays, with a mean duration of 26.1 days. The findings of this investigation underscore the important public health problem of NAS and add to current knowledge on the characteristics of these mothers and infants. Effective June 2014, NAS is now a mandatory reportable condition in Florida. Interventions are also needed to 1) increase the number and use of community resources available to drug-abusing and drug-dependent women of reproductive age, 2) improve drug addiction counseling and rehabilitation referral and documentation policies, and 3) link women to these resources before or earlier in pregnancy. PMID:25742381

  12. CP violation at CDF

    SciTech Connect

    Boudreau, J.

    2001-04-16

    A major goal of experimental particle physics over the next decade is to measure the sides and angles of the Unitarity triangle redundantly, and as precisely as possible. Overconstraining the triangle will test the Cabbibo-Kobayashi-Maskawa model of quark mixing. The CDF collaboration, due to begin a second run in March 2001 with major upgrades to both the accelerator and the detector, will study the angle {beta} using B{sup 0} decays, the angle {gamma} using B{sup 0} and B{sub s}{sup 0} decays, and a side of the triangle through the observation of B{sub s}{sup 0}--{bar B}{sub s}{sup 0} mixing. Projected sensitivities are driven mostly by previous measurements using data from the first run. One highlight of the Run I B physics program is a measurement of the CP violating parameter sin 2{beta} = 0.79{sub {minus}0.44}{sup +0.41}, based on a tagged sample of 400 B{sup 0} decays in the mode B{sub 0}/{bar B}{sup 0} {r_arrow} J/{psi}K{sub s}{sup 0}. The technology of flavor tagging, used here as well as in numerous B{sup 0}-{bar B}{sup 0} mixing analyses in run I, is crucial and will be augmented in Run II with better particle identification capabilities. Exclusive all-hadronic final states will enter the data sample in Run II through a new displaced track trigger.

  13. Why men violate.

    PubMed

    Mcfadden, P

    1993-10-01

    Soldiers in Bosnia-Herzegovina freely rape and kill women. In Botswana, a policeman laughed when a mother reported the rape of her daughter; he commented that some men are fortunate and do not have to pay for sex. His behavior condoned rape as men's right to any female they want. Girls are the most vulnerable of all females. In South Africa, white adults claim that black men and women spread HIV, yet white policemen and white soldiers have raped many black women. White bosses often rape their black housekeepers. A rapist is defined an any man who believes he has the right to rape a woman or child to express his patriarchal sexual power. Most rapists in Africa are black men. Yet many adults continue to deny that male Africans rape and molest children, explaining in part why rape of children and married women is still a silent problem. A study in Zimbabwe shows that the numbers of children less than 11 years old who are raped is increasing quickly (in 1993, 56 of 57 children were girls). Men tend to rape women whom they know, who are often female family members. Men in all classes violate women with whom they work. Rarely do women place themselves in danger. Marital rape is no uncommon, but is often ignored. Society tends to blame the victim, even when she is a child. Same-sex rape does occur, but is rare, and often occurs in prisons. Soldiers, especially during war, believe that women have no value. Men from both sides always consider women to be the enemy. Instead of being captured and shot, women are raped and desecrated as human beings. Often soldiers have no identity outside of their military uniform, and that identity is limited to taking orders, so they assume power over unarmed, defenseless women. PMID:12287226

  14. Hyperscaling violation and the shear diffusion constant

    NASA Astrophysics Data System (ADS)

    Kolekar, Kedar S.; Mukherjee, Debangshu; Narayan, K.

    2016-09-01

    We consider holographic theories in bulk (d + 1)-dimensions with Lifshitz and hyperscaling violating exponents z , θ at finite temperature. By studying shear gravitational modes in the near-horizon region given certain self-consistent approximations, we obtain the corresponding shear diffusion constant on an appropriately defined stretched horizon, adapting the analysis of Kovtun, Son and Starinets. For generic exponents with d - z - θ > - 1, we find that the diffusion constant has power law scaling with the temperature, motivating us to guess a universal relation for the viscosity bound. When the exponents satisfy d - z - θ = - 1, we find logarithmic behaviour. This relation is equivalent to z = 2 +deff where deff =di - θ is the effective boundary spatial dimension (and di = d - 1 the actual spatial dimension). It is satisfied by the exponents in hyperscaling violating theories arising from null reductions of highly boosted black branes, and we comment on the corresponding analysis in that context.

  15. Time reversal violation for entangled neutral mesons

    NASA Astrophysics Data System (ADS)

    Bernabéu, J.

    2013-07-01

    A direct evidence for Time Reversal Violation (TRV) means an experiment that, considered by itself, clearly shows TRV independent of, and unconnected to, the results for CP Violation. No existing result before the recent BABAR experiment with entangled neutral B mesons had demonstrated TRV in this sense. There is a unique opportunity for a search of TRV with unstable particles thanks to the Einstein-Podolsky-Rosen (EPR) Entanglement between the two neutral mesons in B, and PHI, Factories. The two quantum effects of the first decay as a filtering measurement and the transfer of information to the still living partner allow performing a genuine TRV asymmetry with the exchange of "in" and "out" states. With four independent TRV asymmetries, BABAR observes a large deviation of T-invariance with a statistical significance of 14 standard deviations, far more than needed to declare the result as a discovery. This is the first direct observation of TRV in the time evolution of any system.

  16. Direct observation of time reversal violation

    NASA Astrophysics Data System (ADS)

    Bernabéu, J.

    2013-06-01

    A direct evidence for Time Reversal Violation (TRV) means an experiment that, considered by itself, clearly shows TRV independent of, and unconnected to, the results for CP Violation. No existing result before the recent BABAR experiment with entangled neutral B mesons had demonstrated TRV in this sense. There is a unique opportunity for a search of TRV with unstable particles thanks to the Einstein-Podolsky-Rosen (EPR) Entanglement between the two neutral mesons in B, and PHI, Factories. The two quantum effects of the first decay as a filtering measurement and the transfer of information to the still living partner allow performing a genuine TRV asymmetry with the exchange of "in" and "out" states. With four independent TRV asymmetries, BABAR observes a large deviation of T-invariance with a statistical significance of 14 standard deviations, far more than needed to declare the result as a discovery. This is the first direct observation of TRV in the time evolution of any system.

  17. CP Violation in Tau to K* Decays

    SciTech Connect

    Hodgkinson, Mark; /Manchester U.

    2006-03-10

    A sample of {tau}{sup {+-}} {yields} K*{sup {+-}} decays with K*{sup {+-}} {yields} K{sub S}{sup 0}{pi}{sup {+-}} and K{sub S}{sup 0} {yields} {pi}{sup +}{pi}{sup -}, using 123.4 fb{sup -1} of data collected by the BaBar detector at the Stanford Linear Accelerator Center, is used to search for a direct CP violation effect in the charged Higgs sector. No evidence of CP violation is found and the imaginary part of the charged Higgs coupling, {l_brace}Im{r_brace}({Lambda}), in the Multi-Higgs-Doublet-Model is found to be at -0.284 < {l_brace}Im{r_brace}({Lambda}) < 0.200 at 90% Confidence Level. In addition the installation of the kk2f Monte Carlo generator into the BaBar software framework is described.

  18. Are the anterior negativities to grammatical violations indexing working memory?

    PubMed

    Martín-Loeches, Manuel; Muñoz, Francisco; Casado, Pilar; Melcón, A; Fernández-Frías, C

    2005-09-01

    Anterior negativities obtained when a grammatical rule is violated may reflect highly automatic first-pass parsing processes, the detection of a morphosyntactic mismatch, and/or the inability to assign the incoming word to the current phrase structure. However, for some theorists these negativities rather reflect some aspect of working memory processes. Event-related brain potentials (ERPs) obtained for word category and morphosyntactic violations were directly compared with effects obtained when working memory is particularly demanded (embedding subject- or object-relative clauses), yielding a significant dissociation in terms of topography. Even though, the anterior negativities for grammatical violations vanished when relative clauses were embedded, suggesting that the processes reflected by anterior negativities related to grammatical violations and those related to working memory manipulations, even if different, are placing demands on a common pool of limited resources. PMID:16176373

  19. Differences between nicotine-abstinent smokers and non-smokers in terms of visuospatial attention and inhibition before and after single-blind nicotine administration.

    PubMed

    Logemann, H N A; Böcker, K B E; Deschamps, P K H; Kemner, C; Kenemans, J L

    2014-09-26

    The cholinergic system is implicated in visuospatial attention and inhibition, however the exact role is still unclear. Two key mechanisms in visuospatial attention are bias and disengagement. Bias refers to neuronal signals that enhance the sensitivity of the sensory cortex, disengagement is the decoupling of attention. Previous studies suggest that nicotine affects disengagement and (related) inhibition. However the exact relation is still unknown. Furthermore, nicotine-abstinence in 'healthy' smokers may resemble some anomalies of visuospatial attention and inhibition as seen in Attention Deficit/Hyperactivity Disorder (ADHD). Smokers and non-smokers (32 male students) performed in a visuospatial cueing (VSC) task, to assess bias and disengagement, and in a stop-signal task (SST) to assess inhibition. It was expected that nicotine abstinent smokers compared to non-smokers, would show poor disengagement (indicated by an enhanced validity effect) and poor inhibitory control (indicated by an enhanced stop-signal reaction time (SSRT)). It was expected that nicotine would positively affect disengagement and inhibition: hypothesis 1 stated that this effect would be larger in smokers as opposed to non-smokers, in terms of smoking-related deficient inhibitory control. Hypothesis 2 stated the exact opposite, in terms of drug-tolerance. Results indicated no baseline differences. Nicotine enhanced inhibition more in non-smokers relative to smokers. Integrating the results, nicotine-abstinent smokers do not seem to resemble ADHD patients, and do not seem to smoke in order to self-medicate a pre-existing deficit pertaining to mechanisms of visuospatial attention and inhibition. Nicotine may affect inhibition more in non-smokers relative to smokers, consistent with a drug-tolerance account. PMID:25050819

  20. The Knowledge Gap Versus the Belief Gap and Abstinence-Only Sex Education.

    PubMed

    Hindman, Douglas Blanks; Yan, Changmin

    2015-08-01

    The knowledge gap hypothesis predicts widening disparities in knowledge of heavily publicized public affairs issues among socioeconomic status groups. The belief gap hypothesis extends the knowledge gap hypothesis to account for knowledge and beliefs about politically contested issues based on empirically verifiable information. This analysis of 3 national surveys shows belief gaps developed between liberals and conservatives regarding abstinence-only sex education; socioeconomic status-based knowledge gaps did not widen. The findings partially support both belief gap and knowledge gap hypotheses. In addition, the unique contributions of exposure to Fox News, CNN, and MSNBC in this process were investigated. Only exposure to Fox News was linked to beliefs about abstinence-only sex education directly and indirectly through the cultivation of conservative ideology. PMID:25950234

  1. Factors Associated with Sexual Abstinence among Adolescents in Four Sub-Saharan African Countries

    PubMed Central

    Kabiru, Caroline W.; Ezeh, Alex

    2008-01-01

    Drawing on nationally representative data collected from Burkinabé, Ghanaian, Malawian, and Ugandan adolescents, this study examines differences among four groups of never married, 15–19 year olds: primary abstainers (sexually inexperienced), secondary abstainers (last sex more than 12 months prior to the survey), recent abstainers (sexually active in last year but not in the last 3 months), and sexually active (had sexual intercourse in the last 3 months). The percentage of primary abstinent adolescents ranged from 42% (Malawian males) to 85% (Ghanaian males). In general, a greater proportion of females than males were primary abstainers. Primary abstainers were younger than sexually experienced adolescents. Current involvement in a romantic relationship was a significant predictor of sexual status with primary abstainers being the least likely to be romantically involved. Overall, findings suggest that adolescents’ gender, prior sexual experiences and contextual circumstances, such as romantic partnerships, should be considered when designing abstinence promotion programs. PMID:19122794

  2. I want to hold your hand: abstinence curricula, bioethics, and the silencing of desire.

    PubMed

    Wilkerson, Abby

    2013-06-01

    The abstinence approach to sex education remains influential despite its demonstrated ineffectiveness. One bill forbids the "promotion" of "gateway sexual activity," while requiring outright condemnation of "non-abstinence," defined so loosely as to plausibly include handholding. Bioethics seldom (if ever) contributes to sex-ed debates, yet exploring the pivotal role of medical discourse reveals the need for bioethical intervention. Sex-ed debates revolve around a theory of human flourishing based on heteronormative temporality, a developmental teleology ensuring the transmission of various supposed social goods through heterosexual marriage (Halberstam, 2005). Heteronormative temporality also constitutes a moralized discourse in which the values of health and presumed certainties of medicine serve to justify conservative religious dictates that otherwise would appear controversial as the basis for public policy. Overall, this analysis explores how moralized medical discourses compound existing injustices, while suggesting bioethics' potential contributions to moral and political analysis of sex-ed policies. PMID:23468394

  3. CP VIOLATION HIGHLIGHTS: CIRCA 2005

    SciTech Connect

    SONI A.

    2005-02-27

    Recent highlights in CP violation phenomena, are reviewed. B-factory results imply that, CP-violation phase in the CKM matrix is the dominant contributor to the observed CP violation in K and B-physics. Deviations from the predictions of the CKM-paradigm due to beyond the Standard Model CP-odd phase are likely to be a small perturbation. Therefore, large data sample of clean B's will be needed. Precise determination of the unitarity triangle, along with time dependent CP in penguin dominated hadronic and radiative modes are discussed. Null tests in B, K and top-physics and separate determination of the K-unitarity triangle are also emphasized.

  4. From Abstinence to Relapse: A Preliminary Qualitative Study of Drug Users in a Compulsory Drug Rehabilitation Center in Changsha, China

    PubMed Central

    Yang, Mei; Mamy, Jules; Gao, Pengcheng; Xiao, Shuiyuan

    2015-01-01

    Background Relapse among abstinent drug users is normal. Several factors are related to relapse, but it remains unclear what individuals’ actual life circumstances are during periods of abstinence, and how these circumstances facilitate or prevent relapse. Objective To illuminate drug users’ experiences during abstinence periods and explore the real-life catalysts and inhibitors contributing to drug use relapse. Method Qualitative in-depth interviews were conducted with 20 drug users recruited from a compulsory isolated drug rehabilitation center in Changsha. The interviews were guided by open-ended questions on individuals’ experiences in drug use initiation, getting addicted, treatment history, social environment, abstinence, and relapse. Participants were also encouraged to share their own stories. Interviews were digitally recorded and fully transcribed. The data of 18 participants who reported abstinence experiences before admission were included in the analyses. The data were analyzed using a thematic analysis with inductive hand coding to derive themes. Results Most drug users were able to successfully abstain from drugs. During abstinence, their lives were congested with challenges, such as adverse socioeconomic conditions, poor family/social support, interpersonal conflicts, and stigma and discrimination, all of which kept them excluded from mainstream society. Furthermore, the police’s system of ID card registration, which identifies individuals as drug users, worsened already grave situations. Relapse triggers reported by the participants focused mainly on negative feelings, interpersonal conflicts, and stressful events. Craving was experienced but not perceived as a relapse trigger by most participants. Conclusions This study of in-depth interview with drug users found evidence of situations and environments they live during abstinence appear rather disadvantaged, making it extremely difficult for them to remain abstinent. Comprehensive programs

  5. Forced Abstinence from Cocaine Self-Administration is Associated with DNA Methylation Changes in Myelin Genes in the Corpus Callosum: a Preliminary Study

    PubMed Central

    Nielsen, David A.; Huang, Wen; Hamon, Sara C.; Maili, Lorena; Witkin, Brian M.; Fox, Robert G.; Cunningham, Kathryn A.; Moeller, F. Gerard

    2012-01-01

    Background: Human cocaine abuse is associated with alterations in white matter integrity revealed upon brain imaging, an observation that is recapitulated in an animal model of continuous cocaine exposure. The mechanism through which cocaine may affect white matter is unknown and the present study tested the hypothesis that cocaine self-administration results in changes in DNA methylation that could result in altered expression of several myelin genes that could contribute to the effects of cocaine on white matter integrity. Methods: In the present study, we examined the impact of forced abstinence from cocaine self-administration on chromatin associated changes in white matter. To this end, rats were trained to self-administer cocaine (0.75 mg/kg/0.1 mL infusion) for 14 days followed by forced abstinence for 1 day (n = 6) or 30 days (n = 6) before sacrifice. Drug-free, sham surgery controls (n = 7) were paired with the experimental groups. Global DNA methylation and DNA methylation at specific CpG sites in the promoter regions ofmyelin basic protein (Mbp), proteolipid protein-1 (Plp1), and SRY-related HMG-box-10 (Sox10) genes were analyzed in DNA extracted from corpus callosum. Results: Significant differences in the overall methylation patterns of the Sox10 promoter region were observed in the corpus callosum of rats at 30 days of forced abstinence from cocaine self-administration relative to sham controls; the −189, −142, −93, and −62 CpG sites were significantly hypomethylated point-wise at this time point. After correction for multiple comparisons, no differences in global methylation or the methylation patterns of Mbp or Plp1 were found. Conclusion: Forced abstinence from cocaine self-administration was associated with differences in DNA methylation at specific CpG sites in the promoter region of the Sox10 gene in corpus callosum. These changes may be related to reductions in normal age related changes in DNA methylation and

  6. Motives for khat use and abstinence in Yemen - a gender perspective

    PubMed Central

    2010-01-01

    Background Khat consumption is widespread in Yemeni society and causes problems both in economic development and public health. Preventive measures have been largely unsuccessful and the cultivation continues to proliferate. The gender-specific motives for khat use and abstinence were studied to create a toe-hold for more specific interventions. Methods In a quota sample with equal numbers of males, females, abstainers and consumers, 320 subjects were interviewed on their specific opinions about khat and its impact on subjective and public health, and on social and community functioning. Strata were compared in their acceptance and denial of opinions. Notions that could predict abstinence status or gender were identified with multivariate logistic regression analysis. Results Male khat users had a strong identification with khat use, while females were more ambivalent. The notion that khat consumption is a bad habit (odds ratio (OR) 3.4; p < 0.001) and consumers are malnuorished (OR 2.2; p = 0.046) were associated with female gender among khat users. Among the females worries about health impact (OR 3.2; p = 0.040) and loss of esteem in the family (OR 3.1; p = 0.048) when using khat predicted abstinence. Male abstainers opposed khat users in the belief that khat is the cause of social problems (OR 5.1, p < 0.001). Logistic regression reached an accuracy of 75 and 73% for the prediction of abstinence and 71% for gender among consumers. (All models p < 0.001.) Conclusions Distinct beliefs allow a differentiation between males, females, khat users and abstainers when targeting preventive measures. In accordance to their specific values female khat users are most ambivalent towards their habit. Positive opinions scored lower than expected in the consumers. This finding creates a strong toe-hold for gender-specific public health interventions. PMID:21110889

  7. Drug Metabolizing Enzyme and Transporter Gene Variation, Nicotine Metabolism, Prospective Abstinence, and Cigarette Consumption.

    PubMed

    Bergen, Andrew W; Michel, Martha; Nishita, Denise; Krasnow, Ruth; Javitz, Harold S; Conneely, Karen N; Lessov-Schlaggar, Christina N; Hops, Hyman; Zhu, Andy Z X; Baurley, James W; McClure, Jennifer B; Hall, Sharon M; Baker, Timothy B; Conti, David V; Benowitz, Neal L; Lerman, Caryn; Tyndale, Rachel F; Swan, Gary E

    2015-01-01

    The Nicotine Metabolite Ratio (NMR, ratio of trans-3'-hydroxycotinine and cotinine), has previously been associated with CYP2A6 activity, response to smoking cessation treatments, and cigarette consumption. We searched for drug metabolizing enzyme and transporter (DMET) gene variation associated with the NMR and prospective abstinence in 2,946 participants of laboratory studies of nicotine metabolism and of clinical trials of smoking cessation therapies. Stage I was a meta-analysis of the association of 507 common single nucleotide polymorphisms (SNPs) at 173 DMET genes with the NMR in 449 participants of two laboratory studies. Nominally significant associations were identified in ten genes after adjustment for intragenic SNPs; CYP2A6 and two CYP2A6 SNPs attained experiment-wide significance adjusted for correlated SNPs (CYP2A6 PACT=4.1E-7, rs4803381 PACT=4.5E-5, rs1137115, PACT=1.2E-3). Stage II was mega-regression analyses of 10 DMET SNPs with pretreatment NMR and prospective abstinence in up to 2,497 participants from eight trials. rs4803381 and rs1137115 SNPs were associated with pretreatment NMR at genome-wide significance. In post-hoc analyses of CYP2A6 SNPs, we observed nominally significant association with: abstinence in one pharmacotherapy arm; cigarette consumption among all trial participants; and lung cancer in four case:control studies. CYP2A6 minor alleles were associated with reduced NMR, CPD, and lung cancer risk. We confirmed the major role that CYP2A6 plays in nicotine metabolism, and made novel findings with respect to genome-wide significance and associations with CPD, abstinence and lung cancer risk. Additional multivariate analyses with patient variables and genetic modeling will improve prediction of nicotine metabolism, disease risk and smoking cessation treatment prognosis. PMID:26132489

  8. Drug Metabolizing Enzyme and Transporter Gene Variation, Nicotine Metabolism, Prospective Abstinence, and Cigarette Consumption

    PubMed Central

    Bergen, Andrew W.; Michel, Martha; Nishita, Denise; Krasnow, Ruth; Javitz, Harold S.; Conneely, Karen N.; Lessov-Schlaggar, Christina N.; Hops, Hyman; Zhu, Andy Z. X.; Baurley, James W.; McClure, Jennifer B.; Hall, Sharon M.; Baker, Timothy B.; Conti, David V.; Benowitz, Neal L.; Lerman, Caryn; Tyndale, Rachel F.; Swan, Gary E.

    2015-01-01

    The Nicotine Metabolite Ratio (NMR, ratio of trans-3’-hydroxycotinine and cotinine), has previously been associated with CYP2A6 activity, response to smoking cessation treatments, and cigarette consumption. We searched for drug metabolizing enzyme and transporter (DMET) gene variation associated with the NMR and prospective abstinence in 2,946 participants of laboratory studies of nicotine metabolism and of clinical trials of smoking cessation therapies. Stage I was a meta-analysis of the association of 507 common single nucleotide polymorphisms (SNPs) at 173 DMET genes with the NMR in 449 participants of two laboratory studies. Nominally significant associations were identified in ten genes after adjustment for intragenic SNPs; CYP2A6 and two CYP2A6 SNPs attained experiment-wide significance adjusted for correlated SNPs (CYP2A6 PACT=4.1E-7, rs4803381 PACT=4.5E-5, rs1137115, PACT=1.2E-3). Stage II was mega-regression analyses of 10 DMET SNPs with pretreatment NMR and prospective abstinence in up to 2,497 participants from eight trials. rs4803381 and rs1137115 SNPs were associated with pretreatment NMR at genome-wide significance. In post-hoc analyses of CYP2A6 SNPs, we observed nominally significant association with: abstinence in one pharmacotherapy arm; cigarette consumption among all trial participants; and lung cancer in four case:control studies. CYP2A6 minor alleles were associated with reduced NMR, CPD, and lung cancer risk. We confirmed the major role that CYP2A6 plays in nicotine metabolism, and made novel findings with respect to genome-wide significance and associations with CPD, abstinence and lung cancer risk. Additional multivariate analyses with patient variables and genetic modeling will improve prediction of nicotine metabolism, disease risk and smoking cessation treatment prognosis. PMID:26132489

  9. Investigation of the neuroanatomical substrates of reward seeking following protracted abstinence in mice

    PubMed Central

    Madsen, Heather B; Brown, Robyn M; Short, Jennifer L; Lawrence, Andrew J

    2012-01-01

    Persistent vulnerability to relapse represents a major challenge in the treatment of drug addiction. The brain circuitry that underlies relapse-like behaviour can be investigated using animal models of drug seeking. As yet there have been no comprehensive brain mapping studies that have specifically examined the neuroanatomical substrates of cue-induced opiate seeking following abstinence in a mouse operant paradigm. The aim of this study was to compare the brain regions involved in sucrose vs. morphine seeking following protracted abstinence in mice. Male CD1 mice were trained to respond for either sucrose (10% w/v) or intravenous morphine (0.1 mg kg−1 per infusion) in an operant paradigm in the presence of a discrete cue. Once stable responding was established, mice were subjected to abstinence in their home cages for 3 weeks and then perfused for tissue collection, or returned to the operant chambers to assess cue-induced reward seeking before being perfused for tissue collection. Brain tissue was processed for Fos immunohistochemistry and Fos expression was quantified in a range of brain nuclei. We identified unique patterns of neuronal activation for sucrose and morphine seeking mice as well as some overlap. Structures activated in both ‘relapse’ groups included the anterior cingulate and orbitofrontal cortex, nucleus accumbens shell, bed nucleus of the stria terminalis, substantia nigra pars compacta, ventral tegmental area, hippocampus, periaqueductal grey, locus coeruleus and lateral habenula. Structures that were more activated in morphine seeking mice included the nucleus accumbens core, basolateral amygdala, substantia nigra pars reticulata, and the central nucleus of the amygdala. The dorsal raphe was the only structure examined that was specifically activated in sucrose seeking mice. Overall our findings support a cortico-striatal limbic circuit driving opiate seeking, and we have identified some additional circuitry potentially relevant to

  10. Relativistic geometric quantum phases from the Lorentz symmetry violation effects in the CPT-even gauge sector of Standard Model Extension

    NASA Astrophysics Data System (ADS)

    Bakke, K.; Belich, H.

    2015-11-01

    We discuss the appearance of geometric quantum phases for a Dirac neutral particle in the context of relativistic quantum mechanics based on possible scenarios of the Lorentz symmetry violation tensor background in the CPT-even gauge sector of Standard Model Extension. We assume that the Lorentz symmetry breaking is determined by a tensor background given by (KF)μναβ, then, relativistic analogues of the Anandan quantum phase [J. Anandan, Phys. Lett. A 138, 347 (1989)] are obtained based on the parity-even and parity-odd sectors of the tensor (KF)μναβ.

  11. CP violation results from CDF

    SciTech Connect

    Napier, Austin; /Tufts U.

    2012-01-01

    We present world-leading results on CP-violating asymmetries and branching fractions of several decay modes of B{sup 0}, B{sub s}{sup 0}, and {Lambda}{sub b} hadrons into charmless two-body, and of B{sup {+-}} into charm, final states collected by the CDF detector. We also report a new measurement of CP-violating asymmetries in D*{sup {+-}}-tagged D{sup 0} {yields} h{sup +}h{sup -} (h = K or {pi}) decays, where any enhancement from the Standard Model prediction would be unambiguous evidence for New Physics.

  12. Baryon number violation via Majorana neutrinos

    NASA Astrophysics Data System (ADS)

    Zhang, Yue

    2016-06-01

    We propose and investigate a novel, minimal, and experimentally testable framework for baryo- genesis, dubbed dexiogenesis, using baryon number violating effective interactions of right-handed Majorana neutrinos responsible for the seesaw mechanism. The distinct LHC signature of our framework is same-sign top quark final states, possibly originating from displaced vertices. The region of parameters relevant for LHC phenomenology can also yield concomitant signals in nucleon decay experiments. We provide a simple ultraviolet origin for our effective operators, by adding a color-triplet scalar, which could ultimately arise from a grand unified theory.

  13. Animal models of drug relapse and craving: From drug priming-induced reinstatement to incubation of craving after voluntary abstinence.

    PubMed

    Venniro, Marco; Caprioli, Daniele; Shaham, Yavin

    2016-01-01

    High rates of relapse to drug use during abstinence is a defining feature of drug addiction. In abstinent drug users, drug relapse is often precipitated by acute exposure to the self-administered drug, drug-associated cues, stress, as well as by short-term and protracted withdrawal symptoms. In this review, we discuss different animal models that have been used to study behavioral and neuropharmacological mechanisms of these relapse-related phenomena. In the first part, we discuss relapse models in which abstinence is achieved through extinction training, including the established reinstatement model, as well as the reacquisition and resurgence models. In the second part, we discuss recent animal models in which drug relapse is assessed after either forced abstinence (e.g., the incubation of drug craving model) or voluntary (self-imposed) abstinence achieved either by introducing adverse consequences to ongoing drug self-administration (e.g., punishment) or by an alternative nondrug reward using a discrete choice (drug vs. palatable food) procedure. We conclude by briefly discussing the potential implications of the recent developments of animal models of drug relapse after voluntary abstinence to the development of medications for relapse prevention. PMID:26822352

  14. Prolonged sexual abstinence after childbirth: gendered norms and perceived family health risks. Focus group discussions in a Tanzanian suburb

    PubMed Central

    2013-01-01

    Background Prolonged sexual abstinence after childbirth is a socio-cultural practice with health implications, and is described in several African countries, including Tanzania. This study explored discourses on prolonged postpartum sexual abstinence in relation to family health after childbirth in low-income suburbs of Dar es Salaam, Tanzania. Methods Data for the discourse analysis were collected through focus group discussions with first-time mothers and fathers and their support people in Ilala, Dar es Salaam, Tanzania. Results In this setting, prolonged sexual abstinence intended at promoting child health was the dominant discourse in the period after childbirth. Sexual relations after childbirth involved the control of sexuality for ensuring family health and avoiding the social implications of non-adherence to sexual abstinence norms. Both abstinence and control were emphasised more with regard to women than to men. Although the traditional discourse on prolonged sexual abstinence for protecting child health was reproduced in Ilala, some modern aspects such as the use of condoms and other contraceptives prevailed in the discussion. Conclusion Discourses on sexuality after childbirth are instrumental in reproducing gender-power inequalities, with women being subjected to more restrictions and control than men are. Thus, interventions that create openness in discussing sexual relations and health-related matters after childbirth and mitigate gendered norms suppressing women and perpetuating harmful behaviours are needed. The involvement of males in the interventions would benefit men, women, and children through improving the gender relations that promote family health. PMID:23316932

  15. Longitudinal Mapping of Gyral and Sulcal Patterns of Cortical Thickness and Brain Volume Regain during Early Alcohol Abstinence.

    PubMed

    Wang, Guo-Ying; Demirakca, Traute; van Eijk, Julia; Frischknecht, Ulrich; Ruf, Matthias; Ucar, Serhat; Hermann, Derik; Mann, Karl; Kiefer, Falk; Ende, Gabriele

    2016-01-01

    We explored brain volume recovery in terms of cortical thickness (CTh; gyral, sulcal pattern) and surface area (SA), as well as subcortical volume recovery in the first 2 weeks of abstinence in 49 alcohol-dependent patients (ADPs). A widespread reduction of CTh in ADPs at day 1 of abstinence compared to healthy controls, with more pronounced differences in sulci relative to gyri was found. After 2 weeks of abstinence, partial recovery to varying degrees of CTh loss in ADPs was observed for several regions. The longitudinal CTh changes were greater in sulci than in gyri of affected regions. No longitudinal change in SAs and subcortical volumes was found. Alterations of CTh contribute to brain volume loss in alcoholism and recovery during early abstinence. Sulci seem to be more vulnerable to excessive alcohol consumption and to drive abstinence-induced volume recovery. During the initial 2 weeks of abstinence no subcortical volume regain was observed. Either the time span was too short or the lower subcortical volume could represent a predisposing trait marker. PMID:26343988

  16. Persistent Microstructural Deficits of Internal Capsule in One-Year Abstinent Male Methamphetamine Users: a Longitudinal Diffusion Tensor Imaging Study.

    PubMed

    Zhuang, Wenxu; Tang, Yingying; Zhong, Na; Jiang, Haifeng; Du, Jiang; Wang, Jijun; Zhao, Min

    2016-09-01

    White matter (WM) alterations have been reported in methamphetamine (MA) users. However, knowledge about longitudinal changes in WM during abstinence from MA remains unknown. The present study aimed to examine how WM changes in long-term MA abstinent, in particular, whether the WM deficits would recover as the duration of abstinence extended. Twenty male MA dependent individuals and 19 healthy controls (HCs) were recruited and participated in both clinical assessments and diffusion tensor imaging (DTI) scans. The MA group underwent two DTI scans, a baseline scan with a duration of abstinence of 6.4 months and and a follow-up scan with a duration of abstinence of 13.0 months. Tract-Based Spatial Statistics was utilized to conduct baseline DTI analysis of MA group compared with HCs. The clusters with significant group differences of factional anisotropy (FA) were extracted as region of interests (ROIs). Mean values of DTI measurements (FA, mean diffusivity, axial diffusivity and radial diffusivity) were calculated within the ROIs in each subject's native space at baseline and follow-up. The MA group showed significant lower FA in the right internal capsule and superior corona radiate than HCs. The deficits did not recover when the duration of abstinence from MA reached 13 months. No significant correlations were found between FA and clinical measurements. Our results suggested persistent microstructure deficits of WM tracts surrounding the basal ganglia in MA dependent individuals. PMID:27115910

  17. Abnormal resting-state functional connectivity of the nucleus accumbens in multi-year abstinent heroin addicts.

    PubMed

    Zou, Feng; Wu, Xinhuai; Zhai, Tianye; Lei, Yu; Shao, Yongcong; Jin, Xiao; Tan, Shuwen; Wu, Bing; Wang, Lubin; Yang, Zheng

    2015-11-01

    Functional neuroimaging studies suggest that abnormal brain functional connectivity may be the neural underpinning of addiction to illicit drugs and of relapse after successful cessation therapy. Aberrant brain networks have been demonstrated in addicted patients and in newly abstinent addicts. However, it is not known whether abnormal brain connectivity patterns persist after prolonged abstinence. In this cross-sectional study, whole-brain resting-state functional magnetic resonance images (8 min) were collected from 30 heroin-addicted individuals after a long period of abstinence (more than 3 years) and from 30 healthy controls. We first examined the group differences in the resting-state functional connectivity of the nucleus accumbens (NAc), a brain region implicated in relapse-related processes, including craving and reactivity to stress following acute and protracted withdrawal from heroin. We then examined the relation between the duration of abstinence and the altered NAc functional connectivity in the heroin group. We found that, compared with controls, heroin-dependent participants exhibited significantly greater functional connectivity between the right ventromedial prefrontal cortex and the NAc and weaker functional connectivity between the NAc and the left putamen, left precuneus, and supplementary motor area. However, with longer abstinence time, the strength of NAc functional connectivity with the left putamen increased. These results indicate that dysfunction of the NAc functional network is still present in long-term-abstinent heroin-dependent individuals. PMID:26280556

  18. Comparison of expired carbon monoxide and plasma cotinine as markers of cigarette abstinence.

    PubMed

    Jatlow, Peter; Toll, Benjamin A; Leary, Vanessa; Krishnan-Sarin, Suchitra; O'Malley, Stephanie S

    2008-12-01

    The clinical pharmacology of biochemical measures of nicotine exposure has been thoroughly reviewed with regard to usefulness and limitations in detecting abstinence from cigarette smoking. While plasma nicotine concentration measures only acute nicotine exposure, plasma, salivary, and urine cotinine concentrations reflect exposure over an extended period of time. Although, expired carbon monoxide (CO) is frequently used to confirm self reports, it has a relatively short half life, calling into question whether this measure might provide misleading information by exaggerating smoking cessation success rates. To examine this question, we analyzed expired CO, plasma cotinine and self report data collected in a clinical trial in which subjects (N=207) were randomly assigned to gain- or loss-framed messages for smoking cessation in combination with open label sustained-release bupropion (300 mg/day). In examining measurements collected at 6 weeks, 3 and 6 months, results showed that CO significantly overestimated abstinence rates as compared with cotinine, although the discrepancy was less at the later time points. These data suggest that while expired CO is a useful and well-established marker in certain contexts, when testing extended abstinence from smoking with non-nicotine medications, cotinine measurements should be preferred. PMID:18650033

  19. Impact of a brief telephone referral on quitline use, quit attempts and abstinence

    PubMed Central

    Mathew, Amanda R.; Burris, Jessica L.; Alberg, Anthony J.; Cummings, K. Michael; Carpenter, Matthew J.

    2015-01-01

    Quitline use can prompt quit attempts and promote abstinence among smokers, but rates of use are low and outcomes of brief quitline referrals unclear. In this study, a brief intervention was delivered to smokers who expressed motivation to quit in the next 30 days (N = 221) to encourage use of their state quitline. Correlates of quitline use were examined, and quitline callers versus non-callers were compared on the following outcomes at 2-month follow-up: cessation medication use, quit attempts and abstinence. Of the 221 smokers given a quitline referral, 34% called the quitline. Baseline motivation alone distinguished quitline callers from non-callers. Quitline use was positively associated with use of cessation medication, an association that remained robust even after adjusting for baseline motivation to quit. A trend was observed in which callers were marginally more likely than non-callers to report both a 24-h quit attempt and 7-day point prevalence abstinence. Relative to non-callers, callers also endorsed greater confidence to quit and increased self-efficacy to resist smoking temptations at follow-up. This study demonstrates a minimal intervention can promote acceptance of quitlines and favorable cessation outcomes among smokers motivated to quit. PMID:25092882

  20. Alcohol abstinence or harm-reduction? Parental messages for college-bound light drinkers.

    PubMed

    LaBrie, Joseph W; Boyle, Sarah C; Napper, Lucy E

    2015-07-01

    Parental communications about alcohol can have a significant impact on college students' alcohol use; however, it is unclear what types of communication may be most beneficial for reducing alcohol risk, particularly among students who have already initiated alcohol use. The present research examines differences in alcohol use and employment of drinking protective behavioral strategies between pre-college matriculation high school seniors receiving predominantly abstinence parent messaging and students primarily receiving harm-reduction parent messaging. Students who identified as light drinkers were recruited during their last month in high school and completed an online assessment of alcohol use and parent alcohol communication. Analyses revealed that, in comparison to light drinkers who primarily received harm-reduction messaging from parents, light drinkers who received more abstinence messaging reported less frequent alcohol use, lower peak alcohol consumption, and greater use of protective drinking strategies aimed at changing the way they drank and avoiding serious hazards associated with drinking. Findings from this study underscore the utility of messages related to abstinence even for parents who are aware that their children have had previous experiences with alcohol and highlight the need for longitudinal research assessing additional mechanisms associated with message efficacy among light, moderate and heavy drinking students transitioning to college. PMID:25753930