Development of a Novel Tissue Specific Aromatase Activity Regulation Therapeutic Method

DTIC Science & Technology

2009-09-01

Distribution Unlimited 13. SUPPLEMENTARY NOTES 14. ABSTRACT Estrogen is essential for normal growth and development of the female ...the ovaries and other tissues of the body using an enzyme called aromatase. Once women have reached menopause, the ovaries no longer produce estrogen...Introduction Estrogen is essential for normal growth and development of the female reproductive system, including breast tissue, and lifetime

Assessment of the Tensile Properties for Single Fibers

DTIC Science & Technology

2018-02-01

Approved for public release; distribution is unlimited. 14. ABSTRACT A novel experimental test method is presented to assess the tensile properties...distribution is unlimited. iii Contents List of Figures iv List of Tables v Acknowledgments vi 1. Introduction 1 2. Experimental Procedure 2 2.1 Test...fiber diameter measurements .............................. 7 Fig. 5 The coordinate system defining the experimental setup with the x- direction along

SPECSweb Post-Tracking Classification Method

DTIC Science & Technology

2011-07-01

The Specular-Cued Surveillance Web (SPECSweb) multistatic tracker effectively reduces false track rate through the use of two amplitude thresholds...Cueing – Clutter 1 Introduction A concept referred to as the “Specular-Cued Surveillance Web (SPECSweb)” is being pursued to mitigate the data...on 5-8 July 2011. Sponsored in part by Office of Naval Research and U.S. Army Research Laboratory. 14. ABSTRACT The Specular-Cued Surveillance Web

Functional Characterization and Expression of Molluscan Detoxification Enzymes and Transporters Involved in Dietary Allelochemical Resistance

DTIC Science & Technology

2008-06-01

gastropod Cvphoma gibbosum feeding on a variety of chemically defended gorgonian corals, and to identify those dietary natural products that act as...detoxification and transport-mediated resistance to dietary allelochemicals. The ovulid gastropod Cyphoma gibbosum is considered a trophic generalist, feeding...enzymatic activity of glutathione S-transferases from the generalist marine gastropod , Cyphoma gibbosum Abstract 74 Introduction 75 Methods 78 Results 86

Computer Simulation of a Multiaxis Air-to-Air Tracking Task Using the Optimal Pilot Control Model.

DTIC Science & Technology

1982-12-01

v ABSTRACT ........ ............................. .. vi CHAPTER 1 - INTRODUCTION ....... ..................... 1 1.1 Motivation... Introduction ......... . 4 2.2 Optimal Pilot Control Model and Control Synthesis 4 2.3 Pitch Tracking Task ...... ................... 6 2.4 Multiaxis...CHAPTER 3 - SIMULATION SYSTEM ...... .................. 33 3.1 Introduction ........ ....................... 33 3.2 System Hardware

Research Related to Native Peoples at the University of Saskatchewan, 1912-1983.

ERIC Educational Resources Information Center

Barnett, Don C.; Dyer, Aldrich J.

The volume on University of Saskatchewan graduate theses related to Canadian native peoples (Indian, Inuit, Metis) contains a brief introduction, followed by abstracts of 62 thesis projects (1912-1982), and a final section of statistics, charts, summaries, and discussions related to the abstracted research. Each research abstract consists of three…

Angular Superresolution for a Scanning Antenna with Simulated Complex Scatterer-Type Targets

DTIC Science & Technology

2002-05-01

Approved for public release; distribution unlimited. The Scan- MUSIC (MUltiple SIgnal Classification), or SMUSIC, algorithm was developed by the Millimeter...with the use of a single rotatable sensor scanning in an angular region of interest. This algorithm has been adapted and extended from the MUSIC ...simulation. Abstract ii iii Contents 1. Introduction 1 2. Extension of the MUSIC Algorithm for Scanning Antenna 2 2.1 Subvector Averaging Method

Multi-Entity Bayesian Networks Learning in Predictive Situation Awareness

DTIC Science & Technology

2013-06-01

evaluated on a case study from PROGNOS. 15. SUBJECT TERMS 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT Same as Report (SAR) 18...algorithm for MEBN. The methods are evaluated on a case study from PROGNOS. 1 INTRODUCTION Over the past two decades, machine learning has...the MFrag of the child node. Lastly, in the third For-Loop, for all resident nodes in the MTheory, LPDs are generated by MLE. 5 CASE STUDY

A New Interface Specification Methodology and its Application to Transducer Synthesis

DTIC Science & Technology

1988-05-01

structural, and physical. Within each domain descriptive methods are distinguished by the level of abstraction they emphasize. The Gajski -Kuhn Y...4.2. The Gajski -Kuhn Y-chart’s three axes correspond to three different domains for describing designs: behavioral, structural, and physical. The...Gajski83] D. Gajski , R. Kuhn, Guest Editors’ Introduction: New VLSI Tools, IEEE Computer, Vol. 16, No. 12, December 1983. [Girczyc85] E. Girczyc, R

TQM: A bibliography with abstracts. [total quality management

NASA Technical Reports Server (NTRS)

Gottlich, Gretchen L. (Editor)

1992-01-01

This document is designed to function as a special resource for NASA Langley scientists, engineers, and managers during the introduction and development of total quality management (TQM) practices at the Center. It lists approximately 300 bibliographic citations for articles and reports dealing with various aspects of TQM. Abstracts are also available for the majority of the citations. Citations are organized by broad subject areas, including case studies, customer service, senior management, leadership, communication tools, TQM basics, applications, and implementation. An introduction and indexes provide additional information on arrangement and availability of these materials.

MODELING COMPLEX ECOLOGICAL SYSTEMS: AN INTRODUCTION. (R827676)

EPA Science Inventory

The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Concl...

Philosophy and Sociology of Science Evolution and History

NASA Astrophysics Data System (ADS)

Rosen, Joe

The following sections are included: * Concrete Versus Abstract Theoretical Models * Introduction: concrete and abstract in kepler's contribution * Einstein's theory of gravitation and mach's principle * Unitary symmetry and the structure of hadrons * Conclusion * Dedication * Symmetry, Entropy and Complexity * Introduction * Symmetry Implies Abstraction and Loss of Information * Broken Symmetries - Imposed or Spontaneous * Symmetry, Order and Information * References * Cosmological Surrealism: More Than "Eternal Reality" Is Needed * Pythagoreanism in atomic, nuclear and particle physics * Introduction: Pythagoreanism as part of the Greek scientific world view — and the three questions I will tackle * Point 1: the impact of Gersonides and Crescas, two scientific anti-Aristotelian rebels * Point 2: Kepler's spheres to Bohr's orbits — Pythagoreanisms at last! * Point 3: Aristotle to Maupertuis, Emmy Noether, Schwinger * References * Paradigm Completion For Generalized Evolutionary Theory With Application To Epistemology * Evolution Fully Generalized * Entropy: Gravity as Model * Evolution and Entropy: Measures of Complexity * Extinctions and a Balanced Evolutionary Paradigm * The Evolution of Human Society - the Age of Information as example * High-Energy Physics and the World Wide Web * Twentieth Century Epistemology has Strong (de facto) Evolutionary Elements * The discoveries towards the beginning of the XXth Century * Summary and Conclusions * References * Evolutionary Epistemology and Invalidation * Introduction * Extinctions and A New Evolutionary Paradigm * Evolutionary Epistemology - Active Mutations * Evolutionary Epistemology: Invalidation as An Extinction * References

OZONE MODULATION OF VOLATILE HYDROCARBONS USING MEMBRANE INTRODUCTION MASS SPECTROMETRY. (R828179)

EPA Science Inventory

The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Concl...

The Independence and Interdependence of Coacting Observers in Regard to Performance Efficiency, Workload, and Stress in a Vigilance Task

DTIC Science & Technology

2016-09-01

independence/ dependence , evaluation apprehension, workload, stress 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT: SAR 18. NUMBER...indepen- dence/ dependence , evaluation apprehension, workload, stress IntroductIon Vigilance or sustained attention tasks require observers to maintain

Introduction: Occam’s Razor (SOT - Fit for Purpose workshop introduction)

EPA Science Inventory

Mathematical models provide important, reproducible, and transparent information for risk-based decision making. However, these models must be constructed to fit the needs of the problem to be solved. A “fit for purpose” model is an abstraction of a complicated problem that allow...

Complementarity of statistical treatments to reconstruct worldwide routes of invasion: The case of the Asian ladybird Harmonia axyridis

USDA-ARS?s Scientific Manuscript database

Technical Abstract. Molecular markers can provide clear insight into the introduction history of invasive species. However, inferences about recent introduction histories remain challenging, because of the stochastic demographic processes often involved. Approximate Bayesian computation (ABC) can he...

Quality of reporting of trial abstracts needs to be improved: using the CONSORT for abstracts to assess the four leading Chinese medical journals of traditional Chinese medicine

PubMed Central

2010-01-01

Background Due to language limitations, the abstract of journal article may be the only way for people of non-Chinese speaking countries to know about trials in traditional Chinese medicine (TCM). However, little is known about the reporting quality of these trial abstracts. Our study is to assess the reporting quality of abstracts of randomized controlled trials (RCT) published in four leading Chinese medical journals of TCM, and to identify any differences in reporting between the Chinese and English version of the same abstract publication. Method Two reviewers hand-searched the Chinese Journal of Integrated Traditional and Western Medicine, the Chinese Journal of Integrative Medicine, the China Journal of Chinese Materia Medica and the Chinese Acupuncture & Moxibustion for all abstracts of RCTs published between 2006 and 2007. Two reviewers independently assessed the reporting quality of the Chinese and English version of all eligible abstracts based on a modified version of the CONSORT for reporting randomised trials in journal and conference abstracts (CONSORT for abstracts). Results We identified a total of 345 RCTs of TCM with both a Chinese and English abstract. More than half of Chinese abstracts reported details of the trial participants (68%; 234/345), control group intervention (52%; 179/345), the number of participants randomized (73%; 253/345) and benefits when interpreting the trial results (55%; 190/345). Reporting of methodological quality or key features of trial design and trial results were poor; only 2% (7/345) included details of the trial design, 3% (11/345) defined the primary outcome, 5% (17/345) described the methods of random sequence generation, and only 4% (13/345) reported the number of participants analyzed. No abstracts provided details on allocation concealment and trial registration. The percentage agreement in reporting (between the Chinese and English version of the same abstract) ranged from 84% to 100% across individual checklist item. Conclusion The reporting quality of abstracts of RCTs published in these four TCM journals needs to be improved. Since none of the four journals adopted CONSORT for Abstracts, we hope that the introduction and adoption of CONSORT for Abstracts by TCM journals will lead to an improvement in reporting quality. PMID:20615225

Nanotechnology Aerospace Applications (Applications aerospatiales de la nanotechnologie) (CD-ROM)

DTIC Science & Technology

ABSTRACT: The Educational Notes contain the abstracts and the lecture material of ten presentations, which provide a general introduction into... commercialisation . The lectures were held in October and November 2006 in four cities, namely Seattle, USA, Montreal, CAN, Ljubljana, SVN, and Bordeaux, FRA. The

Automatically classifying sentences in full-text biomedical articles into Introduction, Methods, Results and Discussion.

PubMed

Agarwal, Shashank; Yu, Hong

2009-12-01

Biomedical texts can be typically represented by four rhetorical categories: Introduction, Methods, Results and Discussion (IMRAD). Classifying sentences into these categories can benefit many other text-mining tasks. Although many studies have applied different approaches for automatically classifying sentences in MEDLINE abstracts into the IMRAD categories, few have explored the classification of sentences that appear in full-text biomedical articles. We first evaluated whether sentences in full-text biomedical articles could be reliably annotated into the IMRAD format and then explored different approaches for automatically classifying these sentences into the IMRAD categories. Our results show an overall annotation agreement of 82.14% with a Kappa score of 0.756. The best classification system is a multinomial naïve Bayes classifier trained on manually annotated data that achieved 91.95% accuracy and an average F-score of 91.55%, which is significantly higher than baseline systems. A web version of this system is available online at-http://wood.ims.uwm.edu/full_text_classifier/.

Introduction into Sparks of the Learning Analytics Future

ERIC Educational Resources Information Center

Pechenizkiy, Mykola; Gaševic, Dragan

2014-01-01

This section offers a compilation of 16 extended abstracts summarizing research of the doctoral students who participated in the Second Learning Analytics Summer Institute (LASI 2014) held at Harvard University in July 2014. The abstracts highlight the motivation, main goals and expected contributions to the field from the ongoing learning…

Algebraic Functions, Computer Programming, and the Challenge of Transfer

ERIC Educational Resources Information Center

Schanzer, Emmanuel Tanenbaum

2015-01-01

Students' struggles with algebra are well documented. Prior to the introduction of functions, mathematics is typically focused on applying a set of arithmetic operations to compute an answer. The introduction of functions, however, marks the point at which mathematics begins to focus on building up abstractions as a way to solve complex problems.…

Introduction to Stochastic Simulations for Chemical and Physical Processes: Principles and Applications

ERIC Educational Resources Information Center

Weiss, Charles J.

2017-01-01

An introduction to digital stochastic simulations for modeling a variety of physical and chemical processes is presented. Despite the importance of stochastic simulations in chemistry, the prevalence of turn-key software solutions can impose a layer of abstraction between the user and the underlying approach obscuring the methodology being…

Resistance and resilience of alpine lake fauna to fish introductions

Treesearch

R.A. Knapp; K.R. Matthews; O. Sarnelle

2001-01-01

Abstract. This paper reports on the response by amphibians, benthic macroinvertebrates, and zooplankton in naturally fishless alpine lakes to fish introductions and subsequent fish disappearance. We assessed resistance (the degree to which a system is altered when the environment changes) by comparing faunal distribution and abundance in lakes that have never been...

How do Medical Societies Select Science for Conference Presentation? How Should They?

PubMed Central

Kuczmarski, Thomas M.; Raja, Ali S.; Pallin, Daniel J.

2015-01-01

Introduction Nothing has been published to describe the practices of medical societies in choosing abstracts for presentations at their annual meetings. We surveyed medical societies to determine their practices, and also present a theoretical analysis of the topic. Methods We contacted a convenience sample of large U.S. medical conferences, and determined their approach to choosing abstracts. We obtained information from web sites, telephone, and email. Our theoretical analysis compares values-based and empirical approaches for scoring system development. Results We contacted 32 societies and obtained data on 28 (response rate 88%). We excluded one upon learning that research was not presented at its annual meeting, leaving 27 for analysis. Only 2 (7%) made their abstract scoring process available to submitters. Reviews were blinded in most societies (21;78%), and all but one asked reviewers to recuse themselves for conflict of interest (96%). All required ≥3 reviewers. Of the 24 providing information on how scores were generated, 21 (88%) reported using a single gestalt score, and three used a combined score created from pooled domain-specific sub-scores. We present a framework for societies to use in choosing abstracts, and demonstrate its application in the development of a new scoring system. Conclusions Most medical societies use subjective, gestalt methods to select research for presentation at their annual meetings and do not disclose to submitters the details of how abstracts are chosen. We present a new scoring system that is transparent to submitters and reviewers alike with an accompanying statement of values and ground rules. We discuss the challenges faced in selecting abstracts for a large scientific meeting and share the values and practical considerations that undergird the new system. PMID:26265966

Secretarial Science. Curriculum Guides for Two-Year Postsecondary Programs. Volume II.

ERIC Educational Resources Information Center

North Carolina State Dept. of Community Colleges, Raleigh.

The second of three volumes in a postsecondary secretarial science curriculum, this manual contains course syllabi and abstracts of twenty-three courses included in the curriculum. Business and related courses abstracted include Introduction to Business, Business Mathematics, Business Law 1, Economics 1, and Survey of Data Processing Systems.…

Removal of infused water predominantly during insertion (water exchange) is consistently associated with a greater reduction of pain score - review of randomized controlled trials (RCTs) of water method colonoscopy

PubMed Central

Harker, JO; Leung, JW; Siao-Salera, RM; Mann, SK; Ramirez, FC; Friedland, S; Amato, A; Radaelli, F; Paggi, S; Terruzzi, V; Hsieh, YH

2011-01-01

Introduction Variation in the outcomes in RcTs comparing water-related methods and air insufflation during the insertion phase of colonoscopy raises challenging questions regarding the approach. This report reviews the impact of water exchange on the variation in attenuation of pain during colonoscopy by water-related methods. Methods Medline (2008 to 2011) searches, abstracts of the 2011 Digestive Disease Week (DDW) and personal communications were considered to identify RcTs that compared water-related methods and air insufflation to aid insertion of the colonoscope. Results: Since 2008 nine published and one submitted RcTs and five abstracts of RcTs presented at the 2011 DDW have been identified. Thirteen RcTs (nine published, one submitted and one abstract, n=1850) described reduction of pain score during or after colonoscopy (eleven reported statistical significance); the remaining reports described lower doses of medication used, or lower proportion of patients experiencing severe pain in colonoscopy performed with water-related methods compared with air insufflation (Tables 1 and 2). The water-related methods notably differ in the timing of removal of the infused water - predominantly during insertion (water exchange) versus predominantly during withdrawal (water immersion). Use of water exchange was consistently associated with a greater attenuation of pain score in patients who did not receive full sedation (Table 3). Conclusion The comparative data reveal that a greater attenuation of pain was associated with water exchange than water immersion during insertion. The intriguing results should be subjected to further evaluation by additional RcTs to elucidate the mechanism of the pain-alleviating impact of the water method. PMID:22163081

Development of in vivo Biomarkers for Progressive Tau Pathology after Traumatic Brain Injury

DTIC Science & Technology

2014-02-01

release; distribution unlimited 13. SUPPLEMENTARY NOTES 14. ABSTRACT Athletes in contact sports who have sustained multiple concussive traumatic...who have sustained multiple concussive traumatic brain injuries 15-17 may also be at risk for this condition. Currently, there are no methods to...11 Appendices……………………………………………………………………………... 12 4 INTRODUCTION: Athletes in contact sports who have sustained multiple concussive

Establishing Lower Developmental Thresholds for a Common BlowFly: For Use in Estimating Elapsed Time since Death Using Entomologyical Methods

DTIC Science & Technology

2011-10-01

Abstract …….. Forensic entomology is a science used to estimate a post-mortem interval (PMI). Larvae develop at predictable rates and the time interval...Warren,Jodie; DRDC CSS CR 2011-23; Defence R&D Canada – CSS; October 2011. Introduction or background: Forensic entomology is the study of insects...in Europe since the 1850’s. Forensic entomology is now an integral part of a death investigation when estimating a time since death beyond 72 hours

Overview of the biomedical and environmental programs at the Oak Ridge National Laboratory. [Lead abstract

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pfuderer, H.A.; Moody, J.B.

Separate abstracts were prepared for each of the 6 chapters presented by the six divisions involved in the Biomedical and Environmental Sciences Program at Oak Ridge National Laboratory. The introduction is not covered by an abstract and deals with the environmental, health and safety considerations of energy technology decisions, the major initiatives now being taken by these 6 divisions, and recent major accomplishments in the biomedical and environmental science program. (KRM)

Current Projects in Vocational Education-FY 1976. Abstracts of Projects Supported in Fiscal Year 1976 and the Transition Quarter under the Vocational Education Amendments of 1968 (Parts C, D, I and J).

ERIC Educational Resources Information Center

Budke, Wesley E., Comp.; Gordon, Ruth, Comp.

This compilation presents abstracts of 221 new and continuing projects funded by the Division of Research and Demonstration (USOE/BOAE) in fiscal year 1976 and the transition quarter (July 1 - September 30, 1976). Following a narrative introduction and list of project titles, the abstracts are arranged alphabetically by State within each of the…

Enhanced Patient Expectation and Antiemetic Drug Efficacy

DTIC Science & Technology

1999-07-01

NUMBER OF PAGES 15 Breast Cancer Expectancy Antiemetic Nausea and Vomiting Patient Information Side Effect 16. PRICE CODE 17. SECURITY CLASSIFICATION 18... SECURITY CLASSIFICATION OF THIS 19. SECURITY CLASSIFICATION 20. LIMITATION OF ABSTRACT OF REPORT PAGE OF ABSTRACT Unclassified Unclassified...by the introduction of the 5-HT 3 receptor antagonist class of antiemetics (ondansetron, granisetron , tropisitron) have greatly reduced chemotherapy

Coalition for Education in the Outdoors Research Symposium Proceedings (3rd, Bradford Woods, Indiana, January 12-14, 1996).

ERIC Educational Resources Information Center

McAvoy, Leo H., Ed.; Stringer, L. Allison, Ed.; Bialeschki, M. Deborah, Ed.; Young, Anderson B., Ed.

This proceedings includes 18 papers and abstracts of papers presented at the third biennial research symposium of the Coalition for Education in the Outdoors. Following an introduction, "Strengthening the Foundations of Outdoor Education" (Anderson B. Young, Leo H. McAvoy), the papers and abstracts are: "Research in Outdoor…

Moving beyond regression techniques in cardiovascular risk prediction: applying machine learning to address analytic challenges

PubMed Central

Goldstein, Benjamin A.; Navar, Ann Marie; Carter, Rickey E.

2017-01-01

Abstract Risk prediction plays an important role in clinical cardiology research. Traditionally, most risk models have been based on regression models. While useful and robust, these statistical methods are limited to using a small number of predictors which operate in the same way on everyone, and uniformly throughout their range. The purpose of this review is to illustrate the use of machine-learning methods for development of risk prediction models. Typically presented as black box approaches, most machine-learning methods are aimed at solving particular challenges that arise in data analysis that are not well addressed by typical regression approaches. To illustrate these challenges, as well as how different methods can address them, we consider trying to predicting mortality after diagnosis of acute myocardial infarction. We use data derived from our institution's electronic health record and abstract data on 13 regularly measured laboratory markers. We walk through different challenges that arise in modelling these data and then introduce different machine-learning approaches. Finally, we discuss general issues in the application of machine-learning methods including tuning parameters, loss functions, variable importance, and missing data. Overall, this review serves as an introduction for those working on risk modelling to approach the diffuse field of machine learning. PMID:27436868

Writing a qualitative research report.

PubMed

Burnard, Philip

2004-04-01

A research project in nursing or nursing education is probably only complete once the findings have been published. This paper offers a format for writing a qualitative research report for publication. It suggests, at least, the following sections: introduction, aims of the study, review of the literature, sample, data collection methods, data analysis methods, findings, discussion, conclusion, abstract. Each of these sections is addressed along with many written-out examples. In some sections, alternative approaches are suggested. The aim of the paper is to help the neophyte researcher to structure his or her report and for the experienced researcher to reflect on his or her current practice. References to other source material on qualitative research are given.

Writing a qualitative research report.

PubMed

Burnard, Philip

2004-07-01

A research project in nursing or nursing education is probably only complete once the findings have been published. This paper offers a format for writing a qualitative research report for publication. It suggests, at least, the following sections: introduction, aims of the study, review of the literature, sample, data collection methods, data analysis methods, findings, discussion, conclusion, abstract. Each of these sections is addressed along with many written-out examples. In some sections, alternative approaches are suggested. The aim of the paper is to help the neophyte researcher to structure his or her report and for the experienced researcher to reflect on his or her current practice. References to other source material on qualitative research are given.

Non-native fish introductions and the decline of the mountain yellow-legged frog from within protected areas

Treesearch

R.A. Knapp; K.R. Matthews

2000-01-01

Abstract: One of the most puzzling aspects of the worldwide decline of amphibians is their disappearance from within protected areas. Because these areas are ostensibly undisturbed, habitat alterations are generally perceived as unlikely causes. The introduction of non-native fishes into protected areas, however, is a common practice throughout the world and may exert...

Air Cushion Craft Development. First Revision.

DTIC Science & Technology

1980-01-01

xix NOTATION ............ ............................... .... xxi ABSTRACT ............ ............................... .i... 1 ...ADMINISTRATIVE INFORMATION ........... ...................... 1 ACKNOWLEDGMENTS ............. ........................... 2 CHAPTER I - INTRODUCTION...481 REFERENCES ............ .............................. ... 491 vi LIST OF FIGURES Page 1 - Air Cushion Graft

Garter snakes distributions in high elevation aquatic ecosystems: Is there a link with declining amphibian populations and nonnative trout introductions?

Treesearch

K.R. Matthews; R.A. Knapp; K.L. Pope

2002-01-01

ABSTRACT.—The dramatic amphibian population declines reported worldwide likely have important effects on their predators. In the Sierra Nevada, where amphibian declines are well documented and some are closely tied to the introduction of nonnative trout, the mountain garter snake, Thamnophis elegans elegans, preys predominately on amphibians. We surveyed 2103 high-...

Maternal breastfeeding, early introduction of non-breast milk, and excess weight in preschoolers

PubMed Central

Nascimento, Viviane Gabriela; da Silva, Janaína Paula Costa; Ferreira, Patrícia Calesco; Bertoli, Ciro João; Leone, Claudio

2016-01-01

Abstract Objective: Investigate associations between excess weight in preschool children, breastfeeding duration and age of non-breast milk introduction. Methods: Cross-sectional study of a representative sample of 817 preschool children, aged 2-4 years, attending municipal day care centers in the city of Taubaté. The weight and height of children were measured in the day care centers in 2009, 2010 and 2011. The body mass index z-score (BMIz) was calculated and children were classified as risk of overweight (BMIz≥1 to<2) or excess weight (BMIz≥2). Data analysis was carried out by comparison of proportions, coefficient of correlation and multivariate linear regression. Results: The prevalence of risk of overweight was 18.9% and of excess weight (overweight or obesity) was 9.3%. The median duration of breastfeeding and age of introduction of non-breast milk was 6 months. The child's BMIz showed direct correlation with birth weight (r=0.154; p<0.001) and maternal body mass index (BMI) (r=0.113; p=0.002). The correlation was inverse with the total duration of breastfeeding (r=−0.099; p=0.006) and age at non-breast milk introduction (r=−0.112; p=0.002). There was no correlation between the child's BMIz with birth length, duration of exclusive breastfeeding and mother's age. Conclusions: The earlier the introduction of non-breast milk, the higher the correlation with excess weight at preschool age. PMID:27452430

Use of miniplates as a method for orthodontic anchorage: a case report

PubMed Central

Peres, Fernando Gianzanti; Padovan, Luis Eduardo Marques; Kluppel, Leandro Eduardo; Albuquerque, Gustavo Calvalcanti; de Souza, Paulo Cesar Ulson; Claudino, Marcela

2016-01-01

ABSTRACT Introduction: Temporary anchorage devices (TADs) have been developed to be used as direct adjuncts in orthodontic treatment and have facilitated treatment of more complex orthodontic cases, including patients with dental impaction. Objectives: This clinical case reports the applicability of TADs in the orthodontic treatment of a patient with impacted mandibular second molars. Surgical and orthodontic procedures related to the use of miniplates were also discussed in this study. Conclusions: The use of temporary anchorage devices, such as miniplates, can be suggested as an alternative to treat patients with impacted mandibular second molars. PMID:27901235

Essential Elements of Geologic Reports.

ERIC Educational Resources Information Center

Webb, Elmer James

1988-01-01

Described is a report outline for geologic reports. Essential elements include title; abstract; introduction; stratigraphy; petrography; geochemistry; petrology; geophysics; structural geology; geologic history; modeling; economics; conclusions; and recommendations. (Author/CW)

Cauldrons: An Abstraction for Concurrent Problems Solving. Revision.

DTIC Science & Technology

1986-09-01

iaCtio1ns are the cauldron, a mechanism for organizing inference into distinct reasoning contexts: the flmse. a way of mnodularly describing the components...reasoning systems. 1 . Main Points This paper develops three mechanisms for organizing large distributed reasoning systems: Cauldrons -- A chunk of...introduction.s ’Thc goal-node/frame mechanism supports a useful abstraction over the hare cauldrons implementation, providing a protocol for organizing

Proceedings of the First NASA Formal Methods Symposium

NASA Technical Reports Server (NTRS)

Denney, Ewen (Editor); Giannakopoulou, Dimitra (Editor); Pasareanu, Corina S. (Editor)

2009-01-01

Topics covered include: Model Checking - My 27-Year Quest to Overcome the State Explosion Problem; Applying Formal Methods to NASA Projects: Transition from Research to Practice; TLA+: Whence, Wherefore, and Whither; Formal Methods Applications in Air Transportation; Theorem Proving in Intel Hardware Design; Building a Formal Model of a Human-Interactive System: Insights into the Integration of Formal Methods and Human Factors Engineering; Model Checking for Autonomic Systems Specified with ASSL; A Game-Theoretic Approach to Branching Time Abstract-Check-Refine Process; Software Model Checking Without Source Code; Generalized Abstract Symbolic Summaries; A Comparative Study of Randomized Constraint Solvers for Random-Symbolic Testing; Component-Oriented Behavior Extraction for Autonomic System Design; Automated Verification of Design Patterns with LePUS3; A Module Language for Typing by Contracts; From Goal-Oriented Requirements to Event-B Specifications; Introduction of Virtualization Technology to Multi-Process Model Checking; Comparing Techniques for Certified Static Analysis; Towards a Framework for Generating Tests to Satisfy Complex Code Coverage in Java Pathfinder; jFuzz: A Concolic Whitebox Fuzzer for Java; Machine-Checkable Timed CSP; Stochastic Formal Correctness of Numerical Algorithms; Deductive Verification of Cryptographic Software; Coloured Petri Net Refinement Specification and Correctness Proof with Coq; Modeling Guidelines for Code Generation in the Railway Signaling Context; Tactical Synthesis Of Efficient Global Search Algorithms; Towards Co-Engineering Communicating Autonomous Cyber-Physical Systems; and Formal Methods for Automated Diagnosis of Autosub 6000.

Stunden-abstract. Einfuhrung un die Unterrichtseinheit "U.S.A." (A Class-hour Abstract. Introduction to the Teaching Unit "U.S.A.")

ERIC Educational Resources Information Center

Keiner, Helmut

1978-01-01

Describes a class hour in a 10th grade class in English, using the teaching unit "USA." Historical and geographical aspects are considered. The aim is to acquire sociological knowledge and to articulate it in English. For each phase of the hour, introductory questions, goals, and materials used are provided. (Text is in German.) (IFS/WGA)

Double Sampling with Multiple Imputation to Answer Large Sample Meta-Research Questions: Introduction and Illustration by Evaluating Adherence to Two Simple CONSORT Guidelines

PubMed Central

Capers, Patrice L.; Brown, Andrew W.; Dawson, John A.; Allison, David B.

2015-01-01

Background: Meta-research can involve manual retrieval and evaluation of research, which is resource intensive. Creation of high throughput methods (e.g., search heuristics, crowdsourcing) has improved feasibility of large meta-research questions, but possibly at the cost of accuracy. Objective: To evaluate the use of double sampling combined with multiple imputation (DS + MI) to address meta-research questions, using as an example adherence of PubMed entries to two simple consolidated standards of reporting trials guidelines for titles and abstracts. Methods: For the DS large sample, we retrieved all PubMed entries satisfying the filters: RCT, human, abstract available, and English language (n = 322, 107). For the DS subsample, we randomly sampled 500 entries from the large sample. The large sample was evaluated with a lower rigor, higher throughput (RLOTHI) method using search heuristics, while the subsample was evaluated using a higher rigor, lower throughput (RHITLO) human rating method. Multiple imputation of the missing-completely at-random RHITLO data for the large sample was informed by: RHITLO data from the subsample; RLOTHI data from the large sample; whether a study was an RCT; and country and year of publication. Results: The RHITLO and RLOTHI methods in the subsample largely agreed (phi coefficients: title = 1.00, abstract = 0.92). Compliance with abstract and title criteria has increased over time, with non-US countries improving more rapidly. DS + MI logistic regression estimates were more precise than subsample estimates (e.g., 95% CI for change in title and abstract compliance by year: subsample RHITLO 1.050–1.174 vs. DS + MI 1.082–1.151). As evidence of improved accuracy, DS + MI coefficient estimates were closer to RHITLO than the large sample RLOTHI. Conclusion: Our results support our hypothesis that DS + MI would result in improved precision and accuracy. This method is flexible and may provide a practical way to examine large corpora of literature. PMID:25988135

Quality of reporting of trial abstracts needs to be improved: using the CONSORT for abstracts to assess the four leading Chinese medical journals of traditional Chinese medicine.

PubMed

Wang, Ling; Li, Yulin; Li, Jing; Zhang, Mingming; Xu, Lin; Yuan, Wenming; Wang, Gang; Hopewell, Sally

2010-07-08

Due to language limitations, the abstract of journal article may be the only way for people of non-Chinese speaking countries to know about trials in traditional Chinese medicine (TCM). However, little is known about the reporting quality of these trial abstracts. Our study is to assess the reporting quality of abstracts of randomized controlled trials (RCT) published in four leading Chinese medical journals of TCM, and to identify any differences in reporting between the Chinese and English version of the same abstract publication. Two reviewers hand-searched the Chinese Journal of Integrated Traditional and Western Medicine, the Chinese Journal of Integrative Medicine, the China Journal of Chinese Materia Medica and the Chinese Acupuncture & Moxibustion for all abstracts of RCTs published between 2006 and 2007. Two reviewers independently assessed the reporting quality of the Chinese and English version of all eligible abstracts based on a modified version of the CONSORT for reporting randomised trials in journal and conference abstracts (CONSORT for abstracts). We identified a total of 345 RCTs of TCM with both a Chinese and English abstract. More than half of Chinese abstracts reported details of the trial participants (68%; 234/345), control group intervention (52%; 179/345), the number of participants randomized (73%; 253/345) and benefits when interpreting the trial results (55%; 190/345). Reporting of methodological quality or key features of trial design and trial results were poor; only 2% (7/345) included details of the trial design, 3% (11/345) defined the primary outcome, 5% (17/345) described the methods of random sequence generation, and only 4% (13/345) reported the number of participants analyzed. No abstracts provided details on allocation concealment and trial registration. The percentage agreement in reporting (between the Chinese and English version of the same abstract) ranged from 84% to 100% across individual checklist item. The reporting quality of abstracts of RCTs published in these four TCM journals needs to be improved. Since none of the four journals adopted CONSORT for Abstracts, we hope that the introduction and adoption of CONSORT for Abstracts by TCM journals will lead to an improvement in reporting quality.

Technical Review Board Chairperson Guidelines for Conducting Technical Review Boards for Rocket Testing

DTIC Science & Technology

2011-08-17

to create a guide for technical review board chairperson conducting technical review boards for rocket testing performed by the Air Force Research ...BOARDS FOR ROCKET TESTING   TABLE OF CONTENTS List of Acronyms 1 Abstract 2 Chapter 1. Introduction 3 Introduction and Research Question 3...boards for rocket testing performed by the Air Force Research Laboratory’s Space Missile Propulsion Division located at Edwards Air Force Base in

Space-Time, Phenomenology, and the Picture Theory of Language

NASA Astrophysics Data System (ADS)

Grelland, Hans Herlof

To estimate Minkowski's introduction of space-time in relativity, the case is made for the view that abstract language and mathematics carries meaning not only by its connections with observation but as pictures of facts. This view is contrasted to the more traditional intuitionism of Hume, Mach, and Husserl. Einstein's attempt at a conceptual reconstruction of space and time as well as Husserl's analysis of the loss of meaning in science through increasing abstraction is analysed. Wittgenstein's picture theory of language is used to explain how meaning is conveyed by abstract expressions, with the Minkowski space as a case.

Climate change impacts on human exposures to air pollution

EPA Science Inventory

This is an abstract for a presentations at the Annual Conference of the International Society on Exposure Science and Environmental Epidemiology. This presentation will serve as an introduction to the symposium.

Functional Interactions Between c-Src and HER1 Potentiate Neoplastic Transformation: Implications for the Etiology of Human Breast Cancer

DTIC Science & Technology

2000-07-01

receptor 120 16. PRICE CODE 17. SECURITY CLASSIFICATION 18 . SECURITY CLASSIFICATION 19. SECURITY CLASSIFICATION 20. LIMITATION OF ABSTRACT OF REPORT OF...THIS PAGE OF ABSTRACT Unclassified Unclassified Unclassified Unlimited NSN 7540-01-280-5500 Standard Form 298 (Rev. 2-89) Prescribed by ANSI Std. Z39- 18 ... 18 -26 Appended Manuscripts 3 INTRODUCTION Recent work in our laboratory has established the importance of a

Performance Loss of Lithium Ion Polymer Batteries Subjected to Overcharge and Overdischarge Abuse

DTIC Science & Technology

2012-11-16

hexafluorophosphate EC: ethylene carbonate DEC: diethyl carbonate DMC: dimethyl carbonate PC: propylene carbonate     2    2. Introduction  Lithium -ion...Naval Research Laboratory Washington, DC 20375-5320 NRL/MR/6110--12-9455 Performance Loss of Lithium Ion Polymer Batteries Subjected to Overcharge...ABSTRACT c. THIS PAGE 18. NUMBER OF PAGES 17. LIMITATION OF ABSTRACT Performance Loss of Lithium Ion Polymer Batteries Subjected to Overcharge and

N-Terminal Tau Fragments as Biomarkers for Alzheimer’s Disease and Neurotrauma

DTIC Science & Technology

2014-10-01

construed as an official Department of the Army position, policy or decision unless so designated by other documentation. REPORT DOCUMENTATION PAGE Form...SUBJECT TERMS- nothing listed 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT 18. NUMBER OF PAGES 19a. NAME OF RESPONSIBLE PERSON USAMRMC a...REPORT U b. ABSTRACT U c. THIS PAGE U UU 19b. TELEPHONE NUMBER (include area code) 45 Table of Contents Page 1. Introduction

Comparison of tiered formularies and reference pricing policies: a systematic review

PubMed Central

Morgan, Steve; Hanley, Gillian; Greyson, Devon

2009-01-01

Objectives To synthesize methodologically comparable evidence from the published literature regarding the outcomes of tiered formularies and therapeutic reference pricing of prescription drugs. Methods We searched the following electronic databases: ABI/Inform, CINAHL, Clinical Evidence, Digital Dissertations & Theses, Evidence-Based Medicine Reviews (which incorporates ACP Journal Club, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, Cochrane Methodology Register, Database of Abstracts of Reviews of Effectiveness, Health Technology Assessments and NHS Economic Evaluation Database), EconLit, EMBASE, International Pharmaceutical Abstracts, MEDLINE, PAIS International and PAIS Archive, and the Web of Science. We also searched the reference lists of relevant articles and several grey literature sources. We sought English-language studies published from 1986 to 2007 that examined the effects of either therapeutic reference pricing or tiered formularies, reported on outcomes relevant to patient care and cost-effectiveness, and employed quantitative study designs that included concurrent or historical comparison groups. We abstracted and assessed potentially appropriate articles using a modified version of the data abstraction form developed by the Cochrane Effective Practice and Organisation of Care Group. Results From an initial list of 2964 citations, 12 citations (representing 11 studies) were deemed eligible for inclusion in our review: 3 studies (reported in 4 articles) of reference pricing and 8 studies of tiered formularies. The introduction of reference pricing was associated with reduced plan spending, switching to preferred medicines, reduced overall drug utilization and short-term increases in the use of physician services. Reference pricing was not associated with adverse health impacts. The introduction of tiered formularies was associated with reduced plan expenditures, greater patient costs and increased rates of non-compliance with prescribed drug therapy. From the data available, we were unable to examine the hypothesis that tiered formulary policies result in greater use of physician services and potentially worse health outcomes. Conclusion The available evidence does not clearly differentiate between reference pricing and tiered formularies in terms of policy outcomes. Reference pricing appears to have a slight evidentiary advantage, given that patients’ health outcomes under tiered formularies have not been well studied and that tiered formularies are associated with increased rates of medicine discontinuation. PMID:21603047

The critical appraisal of the papers published in the "iranian journal of psychiatry and behavioral sciences", 2007-2010.

PubMed

Kosaryan, Mehrnoosh; Rabiei, Khadijeh

2013-01-01

This study has been done in order to evaluate the papers published in the "Iranian Journal of Psychiatry and Behavioral Sciences" from 2007 to 2010. A questionnaire was developed according to the design, evidence level, and recommendations to write scientific papers. Validity was achieved by consulting experts. Reliability was tested by re-evaluation of 7 randomly selected papers, one month after the first evaluation by Pearson correlation coefficient (r = 0.8). Different parts of the paper, including title, abstract, introduction, materials and methods, results, discussion, and references, were evaluated by a total of 47 questions. Each required item was judged as: appropriate, partially appropriate, not appropriate, and not applicable. SPSS software was used for descriptive analysis. From spring 2007 to summer 2010, 7 issues with 72 papers were published. The most frequent problem in the title was that one could not understand the design of the research by reading it. In the abstract part, in 90% of papers, time and setting of research were not mentioned. Statistical test was not mentioned in 70%, and reliability of the questionnaires was not mentioned in 70% of papers. The discussion part was the hardest part to judge and had few inappropriate issues, such as unnecessary repetition of introduction and/or results; in 20% of papers the conclusion was not appropriate based on the research design. The evaluated papers had strong points, yet more effort is needed for them to approach excellence. None.

The Two-Tier Concept for Economic Impact Analysis: Introduction and User Instructions

DTIC Science & Technology

1982-08-01

ANALYSIS: INTRODUCTION AND USER INSTRUCTIONS 4: by R. D. Webster J. W. Hamilton Dennis Robinson /F. 5u0 M N b ~ 01 Oil Approved for public release...WHICH DO NOT REPRODUCE LEGIBLY. The contents of this report are not to be used for advertising, publication , of promotional purposes. Citation of trade...for public release; distribution unlimited. I7. DISTRIBUTION STATEMENT (of the abstract entered In Block 20. It different from Report) 1

Physiological determinants of human acute hypoxia tolerance.

DOT National Transportation Integrated Search

2013-11-01

AbstractIntroduction. We investigated possible physiological determinants of variability in hypoxia tolerance in subjects given a 5-minute normobaric exposure to 25,000 ft equivalent. Physiological tolerance to hypoxia was defined as the magnitude of...

Introduction of a Current Waveform, Waveshaping Technique to Limit Conduction Loss in High-Frequency DC-DC Converters Suitable for Space Power

DTIC Science & Technology

1990-06-01

resonant Buck converter 19 ABSTRACT (Continue on reverse if necessary and identify by block number) Space power supply manufacturers have tried to...increase power density and construct smaller, highly efficient power supplies by increasing switching frequency. Incorporation of a power MOSFET as a...Michael, Second Reader \\’-. ohn P. Powers , Chairman Department of Electrical Engineering iii ABSTRACT Space power supply manufacturers have tried to

Systematization of the Introduction of IPV and Switch from tOPV to bOPV in the Americas

PubMed Central

Thrush, Elizabeth; Jauregui, Barbara

2017-01-01

Abstract The synchronized introduction of the inactivated polio vaccine (IPV) and the switch from trivalent oral polio vaccine (tOPV) to bivalent oral polio vaccine (bOPV) has constituted an effort without precedents, and with astonishing results. Within the established time frame, all countries in our region managed to carry out the decision, planning, and introduction of this vaccine and subsequent switch to their national immunization schedules. The purpose of this article is to systematize the process of IPV introduction and switch in Latin America and the Caribbean, which constitutes an important piece in the documentation of the polio legacy in the Americas. Regional level as well as country perspectives and viewpoints are described. Analyzing and summarizing the lessons learned from the introduction of IPV and the switch from tOPV to bOPV can be useful for the introduction of new vaccines in the Pan American Health Organization (PAHO) region and in other regions of the world, and to help our own region successfully carry out another synchronized vaccine introduction in the future, if necessary. PMID:28838161

Report-reading patterns of technical managers and nonmanagers

NASA Technical Reports Server (NTRS)

Pinelli, T. E.; Cordle, V. M.; Glassman, M.; Vondran, R. F., Jr.

1984-01-01

A survey to determine the review and reading processes used by technical managers and nonmanagers indicates that the summary, abstract, conclusion, title page, and introduction are the components used most frequently by both groups to decide whether to read a NASA technical report. In the review process, significantly more managers than nonmanagers use the summary and conclusion, whereas significantly more nonmanagers use the abstract and title page. The most common sequence of review consists of the title page, abstract, and summary, in that order, for both groups. In the reading process, the conclusion, results and discussion, and summary are the components read by the highest percentage of both groups.

Innovation in Astronomy Education

NASA Astrophysics Data System (ADS)

Pasachoff, Jay M.; Ros, Rosa M.; Pasachoff, Naomi

2013-01-01

Preface; Part I. General Strategies for Effective Teaching: Introduction; 1. Main objectives of SpS2; 2. Learning astronomy by doing astronomy; 3. Hands-on Universe-Europe; 4. Life on Earth in the atmosphere of the Sun; 5. A model of teaching astronomy to pre-service teachers; 6. How to teach, learn about, and enjoy astronomy; 7. Clickers: a new teaching tool of exceptional promise; 8. Educational opportunities in pro-am collaboration; 9. Teaching history of astronomy to second-year engineering students; 10. Teaching the evolution of stellar and Milky Way concepts through the ages; 11. Educational efforts of the International Astronomical Union; 12. Astronomy in culture; 13. Light pollution: a tool for astronomy education; 14. Astronomy by distance learning; 15. Edible astronomy demonstrations; 16. Amateur astronomers as public outreach partners; 17. Does the Sun rotate around Earth or Earth rotate around the Sun?; 18. Using sounds and sonifications for astronomy outreach; 19. Teaching astronomy and the crisis in science education; 20. Astronomy for all as part of a general education; Poster abstracts; Part II. Connecting Astronomy with the Public: Introduction; 21. A status report from the Division XII working group; 22. Outreach using media; 23. Astronomy podcasting; 24. IAU's communication strategy, hands-on science communication, and the communication of the planet definition discussion; 25. Getting a word in edgeways: the survival of discourse in audiovisual astronomy; 26. Critical evaluation of the new Hall of Astronomy; 27. Revitalizing astronomy teaching through research on student understanding; Poster abstracts; Part III. Effective Use of Instruction and Information Technology: Introduction; 28. ESO's astronomy education program; 29. U.S. student astronomy research and remote observing projects; 30. Global network of autonomous observatories dedicated to student research; 31. Remote telescopes in education: report of an Australian study; 32. Visualizing large astronomical data holdings; Poster abstracts; Part IV. Practical Issues Connected with the Implementation of the 2003 IAU Resolution: Introduction; 33. Stellar evolution for students of Moscow University; 34. Astronomy for everybody: An approach from the CASAO/NAUH view; 35. Toward a new program in astronomy education in secondary schools in Turkey; 36. Universe awareness for young children; 37. Education in Egypt and Egyptian responses to eclipses; 38. Astronomy in the cultural heritage of African societies; 39. Education at the Pierre Auger Observatory: the cinema as a tool in science education; 40. Freshman seminars: interdisciplinary engagements in astronomy; 41. Astronomy for teachers; Poster abstracts; Conclusion.

Innovation in Astronomy Education

NASA Astrophysics Data System (ADS)

Pasachoff, Jay M.; Ros, Rosa M.; Pasachoff, Naomi

2008-07-01

Preface; Part I. General Strategies for Effective Teaching: Introduction; 1. Main objectives of SpS2; 2. Learning astronomy by doing astronomy; 3. Hands-on Universe-Europe; 4. Life on Earth in the atmosphere of the Sun; 5. A model of teaching astronomy to pre-service teachers; 6. How to teach, learn about, and enjoy astronomy; 7. Clickers: a new teaching tool of exceptional promise; 8. Educational opportunities in pro-am collaboration; 9. Teaching history of astronomy to second-year engineering students; 10. Teaching the evolution of stellar and Milky Way concepts through the ages; 11. Educational efforts of the International Astronomical Union; 12. Astronomy in culture; 13. Light pollution: a tool for astronomy education; 14. Astronomy by distance learning; 15. Edible astronomy demonstrations; 16. Amateur astronomers as public outreach partners; 17. Does the Sun rotate around Earth or Earth rotate around the Sun?; 18. Using sounds and sonifications for astronomy outreach; 19. Teaching astronomy and the crisis in science education; 20. Astronomy for all as part of a general education; Poster abstracts; Part II. Connecting Astronomy with the Public: Introduction; 21. A status report from the Division XII working group; 22. Outreach using media; 23. Astronomy podcasting; 24. IAU's communication strategy, hands-on science communication, and the communication of the planet definition discussion; 25. Getting a word in edgeways: the survival of discourse in audiovisual astronomy; 26. Critical evaluation of the new Hall of Astronomy; 27. Revitalizing astronomy teaching through research on student understanding; Poster abstracts; Part III. Effective Use of Instruction and Information Technology: Introduction; 28. ESO's astronomy education program; 29. U.S. student astronomy research and remote observing projects; 30. Global network of autonomous observatories dedicated to student research; 31. Remote telescopes in education: report of an Australian study; 32. Visualizing large astronomical data holdings; Poster abstracts; Part IV. Practical Issues Connected with the Implementation of the 2003 IAU Resolution: Introduction; 33. Stellar evolution for students of Moscow University; 34. Astronomy for everybody: An approach from the CASAO/NAUH view; 35. Toward a new program in astronomy education in secondary schools in Turkey; 36. Universe awareness for young children; 37. Education in Egypt and Egyptian responses to eclipses; 38. Astronomy in the cultural heritage of African societies; 39. Education at the Pierre Auger Observatory: the cinema as a tool in science education; 40. Freshman seminars: interdisciplinary engagements in astronomy; 41. Astronomy for teachers; Poster abstracts; Conclusion.

An Indium Gallium Arsenide Visible/SWIR Focal Plane Array for Low Light Level Imaging

DTIC Science & Technology

1999-08-01

Abstract unclassified Limitation of Abstract unlimited Number of Pages 13 1.0 INTRODUCTION Military uses for the long-wave infrared ( LWIR ) and mid...applications.1,2 There are many military imaging applications becoming apparent in the SWIR band that are not possible in the MWIR or LWIR . Some of the...image is of the raw, uncorrected video output. The dark current has not been subtracted not has any gain nonuniformity been corrected. In the image of

A Comparison of Manual Scaled and Predicted foE and foF1 Critical Frequencies

DTIC Science & Technology

1990-07-01

Statistics for the lonograms Studied 17 xi 1.0 INTRODUCTION The ARTIST autoscaling routines use a predicted foE to determine a range to search for the...recommendations are made to help improve autoscaling . 20. DISTRIBUTIONIAVAILABILITY OF ABSTRACT 21. ABSTRACT SECURITY CLASSIFICATION UUNCLASSIFIEDUNLIMITED 0...to estimate foE. In the ARTIST , the predicted foE is the CCIR model described in the CCIR Supplement Report 252-2.1 We have also tested a foE

Intent Specifications

NASA Technical Reports Server (NTRS)

Leveson, Nancy G.

1995-01-01

We have been investigating the implications of using abstractions based on intent rather than the aggregation and information-hiding abstractions commonly used in software en- gineering: Cognitive psychologists have shown that intent abstraction is consistent with human problem-solving processes. We believe that new types of specifications and designs based on this concept can assist in understanding and specifying requirements, capturing the most important design rationale information in an efficient and economical way, and supporting the process of identifying and analyzing required changes to minimize the introduction of errors. The goal of hierarchical abstraction is to allow both top-down and bottom-up reasoning about a complex system. In computer science, we have made much use of (1) part-whole abstractions where each level of a hierarchy represents an aggregation of the components at a lower level and of (2) information-hiding abstractions where each level contains the same conceptual information but hides some details about the concepts, that is, each level is a refinement of the information at a higher level.

Abstract volume for the 2016 biennial meeting of the Yellowstone Volcano Observatory

USGS Publications Warehouse

Lowenstern, Jacob B.

2016-10-20

IntroductionEvery two years, scientists, natural resource managers, outreach specialists, and a variety of other interested parties get together for the biennial meeting of the Yellowstone Volcano Observatory (YVO). Each time, the theme varies. In past years, we have focused the meeting around topics including monitoring plans, emergency response, geodesy, and outreach. This year, we spent the first half-day devoted to recent research results, plans for upcoming studies, and geothermal monitoring. On the second day, our focus switched to eruption precursors, particularly as they apply to large caldera systems.Very few large explosive eruptions from caldera systems have taken place in recorded history. Therefore, there are few empirical data with which to characterize the nature of volcanic unrest that might precede eruptions with volcano explosivity index (VEI) of six or greater. For this reason, we set up a series of talks that explore what we know and don’t know about large eruptions. We performed an informal expert elicitation (a frequently used method to characterize expert opinion) with a small number of our colleagues, which served as the basis for a productive discussion session.This short volume of abstracts and extended abstracts provides a summary of the presentations made at the YVO meeting held in Mammoth Hot Springs, Wyoming, on May 10–11, 2016.

ROBOTIC SURGERY: BIOETHICAL ASPECTS

PubMed Central

SIQUEIRA-BATISTA, Rodrigo; SOUZA, Camila Ribeiro; MAIA, Polyana Mendes; SIQUEIRA, Sávio Lana

2016-01-01

ABSTRACT Introduction: The use of robots in surgery has been increasingly common today, allowing the emergence of numerous bioethical issues in this area. Objective: To present review of the ethical aspects of robot use in surgery. Method: Search in Pubmed, SciELO and Lilacs crossing the headings "bioethics", "surgery", "ethics", "laparoscopy" and "robotic". Results: Of the citations obtained, were selected 17 articles, which were used for the preparation of the article. It contains brief presentation on robotics, its inclusion in health and bioethical aspects, and the use of robots in surgery. Conclusion: Robotic surgery is a reality today in many hospitals, which makes essential bioethical reflection on the relationship between health professionals, automata and patients. PMID:28076489

Cloud and Traditional Videoconferencing Technology for Telemedicine and Distance Learning

PubMed Central

Zhang, Kai; Locatis, Craig; Ackerman, Michael

2015-01-01

Abstract Introduction: Cloud-based videoconferencing versus traditional systems are described for possible use in telemedicine and distance learning. Materials and Methods: Differences between traditional and cloud-based videoconferencing systems are examined, and the methods for identifying and testing systems are explained. Findings are presented characterizing the cloud conferencing genre and its attributes versus traditional H.323 conferencing. Results: Because the technology is rapidly evolving and needs to be evaluated in reference to local needs, it is strongly recommended that this or other reviews not be considered substitutes for personal hands-on experience. Conclusions: This review identifies key attributes of the technology that can be used to appraise the relevance of cloud conferencing technology and to determine whether migration from traditional technology to a cloud environment is warranted. An evaluation template is provided for assessing systems appropriateness. PMID:25785761

SPYING FOR THE RIGHT REASONS: CONTESTED NORMS IN CYBERSPACE

DTIC Science & Technology

2017-04-06

the organizational built up of the German Cyber Command. iii Abstract When former National Security Agency contractor Edward Snowden...Introduction In June 2013, former National Security Agency (NSA) contractor Edward Snowden revealed that the United States was spying on 122

Linkage to HIV care before and after the introduction of provider-initiated testing and counselling in six Rwandan health facilities.

PubMed

Franse, Carmen B; Kayigamba, Felix R; Bakker, Mirjam I; Mugisha, Veronicah; Bagiruwigize, Emmanuel; Mitchell, Kirstin R; Asiimwe, Anita; Schim van der Loeff, Maarten F

2017-03-01

HIV testing and counselling forms the gateway to the HIV care and treatment continuum. Therefore, the World Health Organization recommends provider-initiated testing and counselling (PITC) in countries with a generalized HIV epidemic. Few studies have investigated linkage-to-HIV-care among out-patients after PITC. Our objective was to study timely linkage-to-HIV-care in six Rwandan health facilities (HFs) before and after the introduction of PITC in the out-patient departments (OPDs). Information from patients diagnosed with HIV was abstracted from voluntary counselling and testing, OPD and laboratory registers of six Rwandan HFs during three-month periods before (March-May 2009) and after (December 2009-February 2010) the introduction of PITC in the OPDs of these facilities. Information on patients' subsequent linkage-to-pre-antiretroviral therapy (ART) care and ART was abstracted from ART clinic registers of each HF. To triangulate the findings from HF routine, a survey was held among patients to assess reasons for non-enrolment. Of 635 patients with an HIV diagnosis, 232 (36.5%) enrolled at the ART clinic within 90 days of diagnosis. Enrolment among out-patients decreased after the introduction of PITC (adjusted odds ratio, 2.0; 95% confidence interval, 1.0-4.2; p = .051). Survey findings showed that retesting for HIV among patients already diagnosed and enrolled into care was not uncommon. Patients reported non-acceptance of disease status, stigma and problems with healthcare services as main barriers for enrolment. Timely linkage-to-HIV-care was suboptimal in this Rwandan study before and after the introduction of PITC; the introduction of PITC in the OPD may have had a negative impact on linkage-to-HIV-care. Healthier patients tested through PITC might be less ready to engage in HIV care. Fear of HIV stigma and mistrust of test results appear to be at the root of these problems.

Abstract Sculptures: Wire and Plaster Cloth Creations.

ERIC Educational Resources Information Center

Hiller, Peter

2001-01-01

Presents a three-dimensional art project for middle-school students in which they create sculptures of plaster cloth and wire. The introduction explains that they learn about Alexander Calder, a master of using wire in art. Discusses how to make the sculptures. (CMK)

Artificial Intelligence Technical Paper Abstracts 1991

DTIC Science & Technology

1992-07-08

f se118urca,. gathering and inaitaing the data nee ded. and completin ene reuewmng the collection f informtio sn continnt rey dsng thi bude estimate...89) Pr’fS o b’ ANS I Sid 139-1 19 0 Table of Contents Introduction

Fugitive methane assessment with mobile and fence line sensors

EPA Science Inventory

There is no published abstract for this short panel talk. The panel presentation titled “Fugitive methane assessment with mobile and fence line sensors” provides a basic introduction to the topic of next generation sensor technologies for identifying and fixing emiss...

Estimating Anesthesia Time Using the Medicare Claim: A Validation Study

PubMed Central

Silber, Jeffrey H.; Rosenbaum, Paul R.; Even-Shoshan, Orit; Mi, Lanyu; Kyle, Fabienne; Teng, Yun; Bratzler, Dale W.; Fleisher, Lee A.

2012-01-01

Introduction Procedure length is a fundamental variable associated with quality of care, though seldom studied on a large scale. We sought to estimate procedure length through information obtained in the anesthesia claim submitted to Medicare to validate this method for future studies. Methods The Obesity and Surgical Outcomes Study enlisted 47 hospitals located across New York, Texas and Illinois to study patients undergoing hip, knee, colon and thoracotomy procedures. 15,914 charts were abstracted to determine body mass index and initial patient physiology. Included in this abstraction were induction, cut, close and recovery room times. This chart information was merged to Medicare claims which included anesthesia Part B billing information. Correlations between chart times and claim times were analyzed, models developed, and median absolute differences in minutes calculated. Results Of the 15,914 eligible patients, there were 14,369 where both chart and claim times were available for analysis. In these 14,369, the Spearman correlation between chart and claim time was 0.94 (95% CI 0.94, 0.95) and the median absolute difference between chart and claim time was only 5 minutes (95% CI: 5.0, 5.5). The anesthesia claim can also be used to estimate surgical procedure length, with only a modest increase in error. Conclusion The anesthesia bill found in Medicare claims provides an excellent source of information for studying operative time on a vast scale throughout the United States. However, errors in both chart abstraction and anesthesia claims can occur. Care must be taken in the handling of outliers in this data. PMID:21720242

Revisiting Caroline Furness's An Introduction to the Study of Variable Stars on its Centenary (Poster abstract)

NASA Astrophysics Data System (ADS)

Larsen, K.

2016-06-01

(Abstract only) A century and one month ago (October 1915) Dr. Caroline Ellen Furness (1869-1936), Director of the Vassar College Observatory, published An Introduction to the Study of Variable Stars. Issued in honor of the fiftieth anniversary of the founding of Vassar College, the work was meant to fill a void in the literature, namely as both an introduction to the topic of variable stars and as a manual explaining how they should be observed and the resulting data analyzed. It was judged to be one of the hundred best books written by an American woman in the last hundred years at the 1933 World's Fair in Chicago. The book covers the relevant history of and background on types of variable stars, star charts, catalogs, and the magnitude scale, then describes observing techniques, including visual, photographic, and photoelectric photometry. The work finishes with a discussion of light curves and patterns of variability, with a special emphasis on eclipsing binaries and long period variables. Furness's work is a valuable snapshot of the state of astronomical knowledge, technology, and observing techniques from a century ago. This presentation will analyze both Furness's book and its reception in the scientific community, and draw parallels to current advice given to beginning variable star observers.

Evaluation, in three provinces, of the introduction and impact of China’s National Essential Medicines Scheme

PubMed Central

Li, Yang; Sufang, Guo; Brant, Philippa; Bin, Li; Hipgrave, David

2013-01-01

Abstract Objective To evaluate implementation of the National Essential Medicines Scheme (NEMS) in rural China. Methods Two rural counties/districts in each of three provinces where NEMS had been implemented were surveyed. Information was collected from NEMS staff at the province, county/district, township and village levels; patients with chronic disease were also interviewed. Service provision, finances, prescriptions, inpatient records and the expenditures of patients with certain diagnoses were investigated in township hospitals and village clinics. The results were compared with the corresponding data recorded before NEMS was introduced. Findings Following the introduction of NEMS, drug procurement in each study location was systematized. Total drug costs declined. This, and improved prescribing, reduced the costs of outpatient and inpatient care and led, apparently, to increased uptake of health services. However, the prices of some drugs had increased and the availability of others had declined. The compensation of health-care providers for NEMS-related reductions in their incomes had been largely ineffective. As a result of the introduction of NEMS, health facilities relied more on public financing. Many health-care providers complained about higher workloads and lower incomes. Conclusion Although it was well conceived, the introduction of NEMS into China’s decentralized, fee-for-service system of health care has not been straightforward. It has highlighted the problems associated with attempts to modernize health care and health financing for patients’ benefit. Sustainable mechanisms to compensate health-care providers for lost income are needed to ensure that NEMS is a success. PMID:23476091

Athlete's foot: oral antifungals

PubMed Central

2015-01-01

Introduction Around 15% to 30% of people are likely to have athlete's foot at any one time. The infection can spread to other parts of the body and to other people. Methods and outcomes We conducted a systematic overview, aiming to answer the following clinical question: What are the effects of oral treatments for athlete's foot? We searched: Medline, Embase, The Cochrane Library, and other important databases up to September 2014 (BMJ Clinical Evidence overviews are updated periodically; please check our website for the most up-to-date version of this overview). Results At this update, searching of electronic databases retrieved 335 studies. After deduplication and removal of conference abstracts, 210 records were screened for inclusion in the overview. Appraisal of titles and abstracts led to the exclusion of 162 studies and the further review of 48 full publications. Of the 48 full articles evaluated, one systematic review was included. We performed a GRADE evaluation for six PICO combinations. Conclusions In this systematic overview, we categorised the efficacy for one intervention based on information relating to the effectiveness and safety of oral antifungals versus placebo and different oral antifungals versus each other.

Burning mouth syndrome

PubMed Central

2016-01-01

Introduction Burning mouth syndrome mainly affects women, particularly after the menopause, when its prevalence may be 18% to 33%. Methods and outcomes We conducted a systematic overview, aiming to answer the following clinical question: What are the effects of selected treatments for burning mouth syndrome? We searched: Medline, Embase, The Cochrane Library, and other important databases up to January 2015 (BMJ Clinical Evidence overviews are updated periodically; please check our website for the most up-to-date version of this overview). Results At this update, searching of electronic databases retrieved 70 studies. After deduplication and removal of conference abstracts, 45 records were screened for inclusion in the overview. Appraisal of titles and abstracts led to the exclusion of 25 studies and the further review of 20 full publications. Of the 20 full articles evaluated, one systematic review and nine RCTs were added at this update. We performed a GRADE evaluation for five PICO combinations. Conclusions In this systematic overview, we categorised the efficacy for six interventions based on information about the effectiveness and safety of alphalipoic acid, benzodiazepines, benzydamine hydrochloride, cognitive behavioural therapy (CBT), selective serotonin re-uptake inhibitors (SSRIs), and tricyclic antidepressants. PMID:26745781

Removal of infused water predominantly during insertion (water exchange) is consistently associated with an increase in adenoma detection rate - review of data in randomized controlled trials (RCTs) of water-related methods

PubMed Central

Harker, JO; Leung, JW; Siao-Salera, RM; Mann, SK; Ramirez, FC; Friedland, S; Amato, A; Radaelli, F; Paggi, S; Terruzzi, V; Hsieh, YH

2011-01-01

Introduction Variation in outcomes in RcTs comparing water-related methods and air insufflation raises challenging questions regarding the new approach. This report reviews impact of water exchange - simultaneous infusion and removal of infused water during insertion on adenoma detection rate (ADR) defined as proportion of patients with a least one adenoma of any size. Methods Medline (2008–2011) searches, abstract of 2011 Digestive Disease Week (DDW) meeting and personal communications were considered to identify RcTs that compared water-related methods and air insufflation to aid insertion of colonoscope. Results Since 2008, eleven reports of RcTs (6 published, 1 submitted and 4 abstracts, n=1728) described ADR in patients randomized to be examined by air and water-related methods. The water-related methods differed in timing of removal of the infused water -predominantly during insertion (water exchange) (n=825) or predominantly during withdrawal (water immersion) (n=903). Water immersion was associated with both increases and decreases in ADR compared to respective air method patients and the net overall change (-7%) was significant. On the other hand water exchange was associated with increases in ADR consistently and the net changes (overall, 8%; proximal overall, 11%; and proximal <10 mm, 12%) were all significant. Conclusion Comparative data generated the hypothesis that significantly larger increases in overall and proximal colon ADRs were associated with water exchange than water immersion or air insufflation during insertion. The hypothesis should be evaluated by RCTs to elucidate the mechanism of water exchange on adenoma detection. PMID:22163082

Stunden-abstract (Class-Hour Plan)

ERIC Educational Resources Information Center

Hohmann, Heinz-Otto

1977-01-01

Offers a class-hour plan for Grade 11 on the theme of "James Thurber, 'The Peacelike Mongoose' - Discussion of Text," dividing the treatment into stages: Introduction and Reading, Text Elucidation, Comprehension Check, Summarizing Content, Reflection, Written Homework. Possible alternative approaches are discussed. (Text is in German.)…

PUBLIC SOURCES OF MUTAGENICITY AND CARCINOGENICITY DATA: USE IN STRUCTURE-ACTIVITY RELATIONSHIP MODELS

EPA Science Inventory

No Abstract - first paragraph of INTRODUCTION

Publicly supported compilations of mutagenicity and carcinogenicity data are available
for a significant number and variety of environmental and industrial chemicals and, to a lesser
extent, pharmaceutical chemicals. T...

Polyamine Analogues as Novel Anti-HER Family Agents in Human Breast Cancer

DTIC Science & Technology

2009-10-01

NOTES 14. ABSTRACT Elevated levels of all three naturally occurring polyamines, spermine, spermidine and putrescine, have been found in breast...Introduction The polyamines, spermine, spermidine and putrescine, are naturally occurring aliphatic cations that are essential for normal cell growth and

Analysis of chemical warfare agents by gas chromatography-mass spectrometry: methods for their direct detection and derivatization approaches for the analysis of their degradation products

DOE Office of Scientific and Technical Information (OSTI.GOV)

Valdez, Carlos A.; Leif, Roald N.; Hok, Saphon

Abstract Chemical warfare agents (CWAs) are unarguably one of the most feared toxic substances produced by mankind. Their inception in conventional warfare can be traced as far back as the Middle Ages but their full breakthrough as central players in bellic conflicts was not realized until World War I. Since then, more modern CWAs along with efficient methods for their manufacture have emerged and violently shaped the way modern warfare and diplomatic relations are conducted. Owing to their mass destruction ability, counter methods to mitigate their impact appeared almost immediately on par with their development. These efforts have focused onmore » their efficient destruction, development of medical countermeasures and their detection by modern analytical chemistry methods. The following review seeks to provide the reader with a broad introduction on their direct detection by gas chromatography-mass spectrometry (GC-MS) and the various sample derivatization methods available for the analysis of their degradation products. The review concentrates on three of the main CWA classes and includes the nerve agents, the blistering agents and lastly, the incapacitating agents. Each section begins with a brief introduction of the CWA along with discussions of reports dealing with their detection in the intact form by GC-MS. Furthermore, as products arising from their degradation carry as much importance as the agents themselves in the field of forensic analysis, the available derivatization methods of these species are presented for each CWA highlighting some examples from our lab in the Forensic Science Center at the Lawrence Livermore National Laboratory.« less

Analysis of chemical warfare agents by gas chromatography-mass spectrometry: methods for their direct detection and derivatization approaches for the analysis of their degradation products

DOE PAGES

Valdez, Carlos A.; Leif, Roald N.; Hok, Saphon; ...

2017-07-25

Abstract Chemical warfare agents (CWAs) are unarguably one of the most feared toxic substances produced by mankind. Their inception in conventional warfare can be traced as far back as the Middle Ages but their full breakthrough as central players in bellic conflicts was not realized until World War I. Since then, more modern CWAs along with efficient methods for their manufacture have emerged and violently shaped the way modern warfare and diplomatic relations are conducted. Owing to their mass destruction ability, counter methods to mitigate their impact appeared almost immediately on par with their development. These efforts have focused onmore » their efficient destruction, development of medical countermeasures and their detection by modern analytical chemistry methods. The following review seeks to provide the reader with a broad introduction on their direct detection by gas chromatography-mass spectrometry (GC-MS) and the various sample derivatization methods available for the analysis of their degradation products. The review concentrates on three of the main CWA classes and includes the nerve agents, the blistering agents and lastly, the incapacitating agents. Each section begins with a brief introduction of the CWA along with discussions of reports dealing with their detection in the intact form by GC-MS. Furthermore, as products arising from their degradation carry as much importance as the agents themselves in the field of forensic analysis, the available derivatization methods of these species are presented for each CWA highlighting some examples from our lab in the Forensic Science Center at the Lawrence Livermore National Laboratory.« less

How to make an effective poster.

PubMed

Shelledy, David C

2004-10-01

Poster presentations given at scientific meetings are widely used in medicine, nursing, and allied health professions to communicate research findings. A good poster presentation can be an effective way to share the results of your research with your peers, in a collegial and non-threatening atmosphere. Feedback received during a poster session can be invaluable in refining your research and preparing for publication in a peer reviewed journal. A typical poster presentation follows the same format as a scientific paper. Poster sections include a title banner, the abstract, introduction, method, results, discussion, conclusions, and tables and figures. Technical details of poster production include decisions on what materials and methods to use to print and display your poster, font size, whether to use a professional graphics department for production, and cost. Presentation of your research at a professional meeting can be a rewarding experience, and is a useful step toward publishing your research in a respected science journal.

MANAGEMENT OF PANCREATICOPLEURAL FISTULAS SECONDARY TO CHRONIC PANCREATITIS

PubMed Central

CAZZO, Everton; APODACA-RUEDA, Márcio; GESTIC, Martinho Antonio; CHAIM, Fábio Henrique Mendonça; de SAITO, Helena Paes de Almeida; UTRINI, Murillo Pimentel; CALLEJAS-NETO, Francisco; CHAIM, Elinton Adami

2017-01-01

ABSTRACT Introduction: Pancreaticopleural fistula is a rare complication of chronic pancreatitis. Objective: To describe pancreaticopleural fistula due to chronic pancreatitis and perform an extensive review of literature on this topic. Methods: Comprehensive narrative review through online research on the databases Medline and Lilacs for articles published over the last 20 years. There were 22 case reports and four case series selected. Results: The main indication for surgical treatment is the failure of clinical and/or endoscopic treatments. Surgery is based on internal pancreatic drainage, especially by means of pancreaticojejunostomy, and/or pancreatic resections. Conclusion: Pancreaticopleural fistula is a rare complication of chronic pancreatitis and the Frey procedure may be an appropriate therapeutic option in selected cases when clinical and endoscopic treatments are unsuccessful. PMID:29019567

The Tower of Hanoi and Inductive Logic

ERIC Educational Resources Information Center

Merrotsy, Peter

2015-01-01

In the "Australian Curriculum," the concept of mathematical induction is first met in the senior secondary subject Specialist Mathematics. This article details an example, the Tower of Hanoi problem, which provides an enactive introduction to the inductive process before moving to more abstract and cognitively demanding representations.…

A Software Laboratory Environment for Computer-Based Problem Solving.

ERIC Educational Resources Information Center

Kurtz, Barry L.; O'Neal, Micheal B.

This paper describes a National Science Foundation-sponsored project at Louisiana Technological University to develop computer-based laboratories for "hands-on" introductions to major topics of computer science. The underlying strategy is to develop structured laboratory environments that present abstract concepts through the use of…

Low Budget Biology: Genetics Unit.

ERIC Educational Resources Information Center

Wartski, Bert; Wartski, Lynn Marie

Some concepts in genetics are difficult for many students to understand. This document provides hands-on, cost efficient, fun activities for students to help them better understand abstract concepts in genetics. Each activity includes: purpose, introduction, materials, procedures, results and conclusion. Some of the topics explored are: (1)…

Detection of methylenecyclopropylglycine (MCPG) and hypoglycin A in litchi fruit (abstract)

USDA-ARS?s Scientific Manuscript database

Introduction Methylenecyclopropylalanine (hypoglycin A), an unusual amino acid, is known to occur in the fruit of Blighia sapida Koenig. Known as ackee fruit, this member of the family Sapindaceae (soapberry family) is associated with a hypoglycemic malady, and Jamaican vomiting sickness. Another f...

Interrogating the variation of element masses and distribution patterns in single cells using ICP-MS with a high efficiency cell introduction system.

PubMed

Wang, Hailong; Wang, Meng; Wang, Bing; Zheng, Lingna; Chen, Hanqing; Chai, Zhifang; Feng, Weiyue

2017-02-01

Cellular heterogeneity is an inherent condition of cell populations, which results from stochastic expression of genes, proteins, and metabolites. The heterogeneity of individual cells can dramatically influence cellular decision-making and cell fate. So far, our knowledge about how the variation of endogenous metals and non-metals in individual eukaryotic cells is limited. In this study, ICP-MS equipped with a high efficiency cell introduction system (HECIS) was developed as a method of single-cell ICP-MS (SC-ICP-MS). The method was applied to the single-cell analysis of Mn, Fe, Co, Cu, Zn, P, and S in human cancer cell lines (HeLa and A549) and normal human bronchial epithelial cell line (16HBE). The analysis showed obvious variation of the masses of Cu, Fe, Zn, and P in individual HeLa cells, and variation of Fe, Zn, and P in individual A549 cells. On the basis of the single-cell data, a multimodal distribution of the elements in the cell population was fitted, which showed marked differences among the various cell lines. Importantly, subpopulations of the elements were found in the cell populations, especially in the HeLa cancer cells. This study demonstrates that SC-ICP-MS is able to unravel the extent of variation of endogenous elements in individual cells, which will help to improve our fundamental understanding of cellular biology and reveal novel insights into human biology and medicine. Graphical abstract The variations of masses and distribution patterns of elements Mn, Fe, Co, Cu, Zn, P, and S in single cells were successfully detected by ICP-MS coupled with a high efficiency cell introduction system (HECIS).

Succeeding in New Vaccine Introduction: Lessons Learned From the Introduction of Inactivated Poliovirus Vaccine in Cameroon, Kenya, and Nigeria

PubMed Central

Snidal, Sarah; Saidu, Yauba; Ojumu, Abiola; Ngatia, Antony; Bagana, Murtala; Mutuku, Faith; Sobngwi, Joelle; Efe-Aluta, Oniovo; Roper, Julia; LeTallec, Yann; Kang’ethe, Alice

2017-01-01

Abstract Introducing a new vaccine is a large-scale endeavor that can face many challenges, resulting in introduction delays and inefficiencies. The development of national task teams and tools, such as prelaunch trackers, for the introduction of new vaccines (hereafter, “new vaccine introductions” [NVIs]) can help countries implement robust project management systems, front-load critical preparatory activities, and ensure continuous communication around vaccine supply and financing. In addition, implementing postlaunch assessments to take rapid corrective action accelerates the uptake of the new vaccines. NVIs can provide an opportunity to strengthen routine immunization, through strengthening program management systems or by reinforcing local immunization managers’ abilities, among others. This article highlights key lessons learned during the introduction of inactivated poliovirus vaccine in 3 countries that would make future NVIs more successful. The article concludes by considering how the Immunization Systems Management Group of the Global Polio Eradication Initiative has been useful to the NVI process and how such global structures could be further enhanced. PMID:28838156

78 FR 22894 - Collection of Information Under Review by Office of Management and Budget

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-17

... Review by Office of Management and Budget AGENCY: Coast Guard, DHS. ACTION: Thirty-day notice requesting... forwarding an Information Collection Request (ICR), abstracted below, to the Office of Management and Budget... collection of information: 1625-NEW, United States Coast Guard Academy Introduction Mission Program...

Operationalising United Nations Security Council Resolution 1325 within the Australian Defence Force

DTIC Science & Technology

2016-01-01

Hutchinson Joint & Operations Analysis Division Defence Science and Technology Group DST- Group -GD-0909 ABSTRACT This literature...LIMITATION UNCLASSIFIED UNCLASSIFIED Published by Joint & Operations Analysis Division Defence Science and Technology Group 506 Lorimer St...This page intentionally blank UNCLASSIFIED DST- Group -GD-0909 UNCLASSIFIED Contents 1. INTRODUCTION

A Graphical Introduction to the Derivative

ERIC Educational Resources Information Center

Samuels, Jason

2017-01-01

Calculus has frequently been called one the greatest intellectual achievements of humankind. As a key transitional course to college mathematics, it combines such elementary ideas as rate with new abstract ideas--such as infinity, instantaneous change, and limit--to formulate the derivative and the integral. Most calculus texts begin with the…

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

Information is presented under the following section headings: introduction; user guide; information sources; recent releases; and, literature review. The literature reviewed includes abstracts when available on the following subjects: general; geology; environmental quality; hydrology; vegetation; oceanography; regional planning and land use; data manipulation; and instrumentation and technology. An author index and document order form are included. (JGB)

COMPARISON OF PBDES IN CAT SERUM TO LEVELS IN CAT FOOD: EVIDENCE OF DECA DEBROMINATION?

EPA Science Inventory

Abstract Since the introduction of brominated flame retardants (such as the PBDEs), increases in feline hyperthyroidism have been observed. We hypothesized that PBDE exposure was linked to the increased occurrence of hyperthyroidism in cats. Herein, PBDEs in serum of pet ...

Goddard Laboratory for Atmospheric Science, collected reprints 1978-1979, volume 1

NASA Technical Reports Server (NTRS)

Skillman, W. C. (Editor); Kreins, E. R. (Editor)

1981-01-01

A ready reference is presented to 61 papers by members of the Laboratory published between January 1, 1978 and December 31, 1979. To avoid unnecessary duplication, only abstracts or introductions of NASA reports and conference proceedings are included with reprints of articles from various journals.

OUR EVOLVING UNDERSTANDING OF THE ANAEROBIC BIODEGRADATION OF BTEX COMPOUNDS IN GROUND WATER (ABSTRACT ONLY)

EPA Science Inventory

In the early 1980s the ground water community became aware of widespread contamination of groundwater by benzene, toluene, ethylbenzene and xylenes (BTEX compounds) from gasoline spills from underground storage tanks. This new awareness was made possible by the introduction of t...

‘Never heard of it’– Understanding the public’s lack of awareness of a new electronic patient record

PubMed Central

Bratan, Tanja; Stramer, Katja; Greenhalgh, Trisha

2010-01-01

Abstract Background  The introduction of electronic patient records that are accessible by multiple providers raises security issues and requires informed consent – or at the very least, an opportunity to opt out. Introduction of the Summary Care Record (SCR) (a centrally stored electronic summary of a patient’s medical record) in pilot sites in the UK was associated with low awareness, despite an intensive public information programme that included letters, posters, leaflets, and road shows. Aim  To understand why the public information programme had limited impact and to learn lessons for future programmes. Methods  Linguistic and communications analysis of components of the programme, contextualized within a wider mixed‐method case study of the introduction of the SCR in pilot sites. Theoretical insights from linguistics and communication studies were applied. Results  The context of the SCR pilots and the linked information programme created inherent challenges which were partially but not fully overcome by the efforts of campaigners. Much effort was put into designing the content of a mail merge letter, but less attention was given to its novelty, linguistic style, and rhetorical appeal. Many recipients viewed this letter as junk mail or propaganda and discarded it unread. Other components of the information programme were characterized by low visibility, partly because only restricted areas were participating in the pilot. Relatively little use was made of interpersonal communication channels. Conclusion  Despite ethical and legal imperatives, informed consent for the introduction of shared electronic records may be difficult to achieve through public information campaigns. Success may be more likely if established principles of effective mass and interpersonal communication are applied. PMID:20579117

Mathematical biology modules based on modern molecular biology and modern discrete mathematics.

PubMed

Robeva, Raina; Davies, Robin; Hodge, Terrell; Enyedi, Alexander

2010-01-01

We describe an ongoing collaborative curriculum materials development project between Sweet Briar College and Western Michigan University, with support from the National Science Foundation. We present a collection of modules under development that can be used in existing mathematics and biology courses, and we address a critical national need to introduce students to mathematical methods beyond the interface of biology with calculus. Based on ongoing research, and designed to use the project-based-learning approach, the modules highlight applications of modern discrete mathematics and algebraic statistics to pressing problems in molecular biology. For the majority of projects, calculus is not a required prerequisite and, due to the modest amount of mathematical background needed for some of the modules, the materials can be used for an early introduction to mathematical modeling. At the same time, most modules are connected with topics in linear and abstract algebra, algebraic geometry, and probability, and they can be used as meaningful applied introductions into the relevant advanced-level mathematics courses. Open-source software is used to facilitate the relevant computations. As a detailed example, we outline a module that focuses on Boolean models of the lac operon network.

Mathematical Biology Modules Based on Modern Molecular Biology and Modern Discrete Mathematics

PubMed Central

Davies, Robin; Hodge, Terrell; Enyedi, Alexander

2010-01-01

We describe an ongoing collaborative curriculum materials development project between Sweet Briar College and Western Michigan University, with support from the National Science Foundation. We present a collection of modules under development that can be used in existing mathematics and biology courses, and we address a critical national need to introduce students to mathematical methods beyond the interface of biology with calculus. Based on ongoing research, and designed to use the project-based-learning approach, the modules highlight applications of modern discrete mathematics and algebraic statistics to pressing problems in molecular biology. For the majority of projects, calculus is not a required prerequisite and, due to the modest amount of mathematical background needed for some of the modules, the materials can be used for an early introduction to mathematical modeling. At the same time, most modules are connected with topics in linear and abstract algebra, algebraic geometry, and probability, and they can be used as meaningful applied introductions into the relevant advanced-level mathematics courses. Open-source software is used to facilitate the relevant computations. As a detailed example, we outline a module that focuses on Boolean models of the lac operon network. PMID:20810955

Extending Automatic Parallelization to Optimize High-Level Abstractions for Multicore

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liao, C; Quinlan, D J; Willcock, J J

2008-12-12

Automatic introduction of OpenMP for sequential applications has attracted significant attention recently because of the proliferation of multicore processors and the simplicity of using OpenMP to express parallelism for shared-memory systems. However, most previous research has only focused on C and Fortran applications operating on primitive data types. C++ applications using high-level abstractions, such as STL containers and complex user-defined types, are largely ignored due to the lack of research compilers that are readily able to recognize high-level object-oriented abstractions and leverage their associated semantics. In this paper, we automatically parallelize C++ applications using ROSE, a multiple-language source-to-source compiler infrastructuremore » which preserves the high-level abstractions and gives us access to their semantics. Several representative parallelization candidate kernels are used to explore semantic-aware parallelization strategies for high-level abstractions, combined with extended compiler analyses. Those kernels include an array-base computation loop, a loop with task-level parallelism, and a domain-specific tree traversal. Our work extends the applicability of automatic parallelization to modern applications using high-level abstractions and exposes more opportunities to take advantage of multicore processors.« less

Editors' Introduction: Abstract Concepts: Structure, Processing, and Modeling.

PubMed

Bolognesi, Marianna; Steen, Gerard

2018-06-22

Our ability to deal with abstract concepts is one of the most intriguing faculties of human cognition. Still, we know little about how such concepts are formed, processed, and represented in mind. For example, because abstract concepts do not designate referents that can be experienced through our body, the role of perceptual experiences in shaping their content remains controversial. Current theories suggest a variety of alternative explanations to the question of "how abstract concepts are represented in the human mind." These views pinpoint specific streams of semantic information that would play a prominent role in shaping the content of abstract concepts, such as situation-based information (e.g., Barsalou & Wiemer-Hastings, ), affective information (Kousta, Vigliocco, Vinson, Andrews, & Del Campo, ), and linguistic information (Louwerse, ). Rarely, these theoretical views are directly compared. In this special issue, current views are presented in their most recent and advanced form, and directly compared and discussed in a debate, which is reported at the end of each article. As a result, new exciting questions and challenges arise. These questions and challenges, reported in this introductory article, can arguably pave the way to new empirical studies and theoretical developments on the nature of abstract concepts. © 2018 Cognitive Science Society, Inc.

A forecast of typhoid conjugate vaccine introduction and demand in typhoid endemic low- and middle-income countries to support vaccine introduction policy and decisions

PubMed Central

Ramani, Enusa; Park, Il Yeon; Lee, Jung Seok

2017-01-01

ABSTRACT A Typhoid Conjugate Vaccine (TCV) is expected to acquire WHO prequalification soon, which will pave the way for its use in many low- and middle-income countries where typhoid fever is endemic. Thus it is critical to forecast future vaccine demand to ensure supply meets demand, and to facilitate vaccine policy and introduction planning. We forecasted introduction dates for countries based on specific criteria and estimated vaccine demand by year for defined vaccination strategies in 2 scenarios: rapid vaccine introduction and slow vaccine introduction. In the rapid introduction scenario, we forecasted 17 countries and India introducing TCV in the first 5 y of the vaccine's availability while in the slow introduction scenario we forecasted 4 countries and India introducing TCV in the same time period. If the vaccine is targeting infants in high-risk populations as a routine single dose, the vaccine demand peaks around 40 million doses per year under the rapid introduction scenario. Similarly, if the vaccine is targeting infants in the general population as a routine single dose, the vaccine demand increases to 160 million doses per year under the rapid introduction scenario. The demand forecast projected here is an upper bound estimate of vaccine demand, where actual demand depends on various factors such as country priorities, actual vaccine introduction, vaccination strategies, Gavi financing, costs, and overall product profile. Considering the potential role of TCV in typhoid control globally; manufacturers, policymakers, donors and financing bodies should work together to ensure vaccine access through sufficient production capacity, early WHO prequalification of the vaccine, continued Gavi financing and supportive policy. PMID:28604164

Students' Attitudes toward ABI/INFORM on CD-ROM: A Factor Analysis.

ERIC Educational Resources Information Center

Wang, Vicky; Lau, Shuk-fong

Two years after the introduction of CD-ROM bibliographic database searching in the Memphis State University libraries (Tennessee), a survey was conducted to examine students' attitudes toward the business database, ABI/INFORM. ABI/INFORM contains indexes and abstracts of articles from over 800 journals on management, accounting, banking, human…

Look--It's a Comet!

ERIC Educational Resources Information Center

Berglund, Kay

1997-01-01

Describes a classroom lesson on comets that uses modeling and guided imagery to spark students' curiosity. Comet models are built using chunks of rock salt, polystyrene balls, and tinsel. Abstract ideas are made more concrete with a guided imagery story called Comet Ride! Includes an introduction to the use of parallax to measure the distance of…

Abstract of Capstone

ERIC Educational Resources Information Center

Pack, Della F.

2013-01-01

At the end of the Fall 2011 semester at Big Sandy Community and Technical College (BSCTC) a comparison of grade patterns in multiple CIS 100-Introduction to Computers courses was analyzed. This analysis found online courses returned a higher failure rate than those taught in a classroom setting. Why was there a difference? Is the platform of…

The efficacy of potassium ferrate as a chemical disinfectant on E. coli, Vibrio cholera, human adenovirus, and Giardia lamblia - Abstract

EPA Science Inventory

Introduction: Drinking water and wastewater effluents go through numerous treatments to remove microorganisms and other contaminants in the United States. One of many processes along the treatment train is disinfection, and to date the most common disinfectants still remain chemi...

Action-Based Digital Tools: Mathematics Learning in 6-Year-Old Children

ERIC Educational Resources Information Center

Dejonckheere, Peter J. N.; Desoete, Annemie; Fonck, Nathalie; Roderiguez, Dave; Six, Leen; Vermeersch, Tine; Vermeulen, Lies

2014-01-01

Introduction: In the present study we used a metaphorical representation in order to stimulate the numerical competences of six-year-olds. It was expected that when properties of physical action are used for mathematical thinking or when abstract mathematical thinking is grounded in sensorimotor processes, learning gains should be more pronounced…

IN SILICO APPROACHES TO MECHANISTIC AND PREDICTIVE TOXICOLOGY: AN INTRODUCTION TO BIOINFORMATICS FOR TOXICOLOGISTS. (R827402)

EPA Science Inventory

Abstract

Bioinformatics, or in silico biology, is a rapidly growing field that encompasses the theory and application of computational approaches to model, predict, and explain biological function at the molecular level. This information rich field requires new ...

THE DISTRIBUTION OF ALUMINUM INTO AND OUT OF THE BRAIN. (R825357)

EPA Science Inventory

Abstract

The extent, rate and possible mechanism(s) by which aluminum enters and is removed from the brain are presented. Introduction of Al into systemic circulation as Al·transferrin, the predominant Al species in plasma, resulted in about 7...

BNL National Synchrotron Light Source activity report 1997

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

During FY 1997 Brookhaven National Laboratory celebrated its 50th Anniversary and 50 years of outstanding achievement under the management of Associated Universities, Inc. This progress report is divided into the following sections: (1) introduction; (2) science highlights; (3) meetings and workshops; (4) operations; (5) projects; (6) organization; and (7) abstracts and publications.

Relatorio: Reforma universitaria (Report: University Reform).

ERIC Educational Resources Information Center

Ministerio da Educacao e Cultura, Rio de Janeiro (Brazil).

This document is an English-language abstract (approximately 1,500 words) of a report by 11 experts invited by the Ministry of Education and Culture to give their views on Brazilian university reforms. The introduction to the report states the principles underlying the proposals for reform adapted to the current social transformation in Brazil.…

AdaMeasure: An Implementation of the Halstead and Henry Metrics.

DTIC Science & Technology

1987-06-01

of Departne t o Computer Science Kneale T..Nar4 ___. Dean of Information and Policy bScic:-n-- 2 Allr ABSTRACT I A software metric is a tool that...CONTENTS INTRODUCTION AND BACKGROUND ......................... 6 A. DEFINITIONS ..................................................... 6 B. SALLIE HENRY’S...METRIC.................................... 6 C. INFORMATION FLOW .......................................... 7 D. RELATIONS

On the Axiomatization of Mathematical Understanding: Continuous Functions in the Transition to Topology

ERIC Educational Resources Information Center

Cheshire, Daniel C.

2017-01-01

The introduction to general topology represents a challenging transition for students of advanced mathematics. It requires the generalization of their previous understanding of ideas from fields like geometry, linear algebra, and real or complex analysis to fit within a more abstract conceptual system. Students must adopt a new lexicon of…

Constructing the Components of a Lab Report Using Peer Review

ERIC Educational Resources Information Center

Berry, David E.; Fawkes, Kelli L.

2010-01-01

A protocol that emphasizes lab report writing using a piecemeal approach coupled with peer review is described. As the lab course progresses, the focus of the report writing changes sequentially through the abstract and introduction, the discussion, and the procedure. Two styles of lab programs are presented. One style rotates the students through…

Impact of Ten-Valent Pneumococcal Conjugate Vaccine Introduction on Serotype Distribution Trends in Colombia: An Interrupted Time-Series Analysis

PubMed Central

Leal, Aura Lucia; Montañez, Anita Maria; Buitrago, Giancarlo; Patiño, Jaime; Camacho, German; Moreno, Vivian Marcela; Colombia, Red Neumo

2017-01-01

Abstract Background Trends in distribution of S. pneumoniae capsular serotypes are associated with the introduction of pneumococcal conjugate vaccines (PCV) among population. In Colombia, 10-valent PCV (PCV10) has been included in the national vaccination program since 2011. As a part of the pneumococcal surveillance network (SIREVA), Colombia has gathered data of serotype distribution since 1993. The aim of this work is to determine the effect of PCV10 introduction on non-coverage serotypes by PCV10 in Colombia, specifically, the effect on 6A, 19A and 3 serotypes. Methods Information was obtained from the national surveillance program since 1993 to 2016 in children under 5 years. The isolates came from sterile sites (blood, cerebrospinal fluid, pleural fluid, articular and peritoneal fluids). All the isolates were serotyping by National Institute of Health. An interrupted time series analysis was performed to determine the effect of the PCV10 introduction on the 6A, 19A and 3 serotypes (ARIMA model). Results Serotyping was performed in 4683 isolates. The annual proportion trend of the 6A, 19A and 3 serotypes remained constant until 2012. An increase of double in the serotype proportion trends was observed after 2012 (Figure). The interrupted time-series analysis showed a positive effect of the PCV10 introduction on trends of 19A and 3 serotypes, with coefficients 20.92 (P = 0.00, ARIMA(2,0,1)) and 6.32 (P = 0.00, ARIMA(2,1,1), respectively. There was no significant effect on 6A serotype trend. Conclusion The introduction of PCV10 in the national vaccination program in Colombia, affected the distribution of PVC 13 capsular types non included in the PCV 7 and PCV 10 in children under 5 years. This information emphasizes the importance to surveillance the changes in serotype distributions to guide prevention strategies in children under 5 years in Colombia. Figure. 1 Trends in distribution of serotypes 19A, 3 and 6A in children under 5 years. Colombia. Disclosures All authors: No reported disclosures.

The effectiveness and safety of amisulpride in Chinese patients with schizophrenia: An 8‐week, prospective, open‐label, multicenter, single‐arm study

PubMed Central

Liang, Ying; Cao, Changan; Zhu, Cheng; Wang, Chuanyue; Zhang, Congpei; Dong, Fang; Yang, Fude; Deng, Hong; Yu, Jingjie; Tang, Jisheng; Su, Lei; Xin, Limin; Hong, Ling; Gao, Minglong; Tang, Muni; Xie, Shiping; Lu, Shuiping; Liu, Tiebang; Xu, Xiaojin; Wang, Xijin; Li, Xuanzi; Wang, Xueyi; Li, Yi; Zhang, Yong; Chen, Zhiyu

2016-01-01

Abstract Introduction This study evaluated the effectiveness and safety of amisulpride in Chinese schizophrenia patients. Methods A multicenter, single‐arm Phase IV study (NCT01795183). Chinese patients with schizophrenia received amisulpride for 8 weeks. The primary endpoint was ≥50% decrease in Positive and Negative Syndrome Scale total score from Baseline to Week 8. Results A total of 316 patients were enrolled; 295 were included in the effectiveness analysis; 66.8% (197/295) achieved ≥50% decrease in Positive and Negative Syndrome Scale total score from Baseline to Week 8. Nine patients discontinued treatment because of adverse events. Discussion Amisulpride had clinical effectiveness and was relatively well tolerated in Chinese patients with schizophrenia. PMID:27020720

Introduction of an all-electronic administrative process for a major international pediatric surgical meeting.

PubMed

Applebaum, Harry; Boles, Kay; Atkinson, James B

2003-12-01

The administrative process for annual meetings is time consuming and increasingly costly when accomplished by traditional postal, fax, and telephone methods. The Pacific Association of Pediatric Surgeons introduced an all-electronic communication format for its 2002 annual meeting. Attendee acceptance and administrative and financial impact were evaluated. Interested physicians were directed to a Website containing detailed information and electronic forms. E-mail was used for the abstract selection and manuscript submission processes. Attendees were surveyed to evaluate the new format. Administrative costs for the new format were compared with estimated costs for a comparable traditionally managed meeting. Attendance was similar to that at previous US meetings. Eighty-two percent of respondents approved of the all-electronic format, although 48% believed a choice should remain. None suggested a complete return to the traditional format. Abstract and manuscript processing time was reduced substantially as were administrative costs (79.43 dollars savings per physician registrant). Adoption of an all-electronic annual meeting administrative process was associated with substantial cost reduction, increased efficiency, and excellent attendee satisfaction. This technology can help avoid increased registration fees while easing the burden on physician volunteers.

Correlates of Attempted Suicide from the Emergency Room of 2 General Hospitals in Montreal, Canada

PubMed Central

Low, Nancy C. P.; Lamarre, Suzanne; Daneau, Diane; Habel, Youssef; Turecki, Gustavo; Bonin, Jean-Pierre; Morin, Suzanne; Szkrumelak, Nadia; Singh, Santokh; Lesage, Alain

2016-01-01

Introduction: The epidemiology of attempted suicide has not been well characterized because of lack of national data or an International Classification of Diseases (ICD) code for suicide attempts. We conducted a retrospective chart review in 2 adult general hospitals (tertiary and community) in Montreal, Canada, in 2009-2010 to 1) describe the characteristics of men and women who presented to the emergency department (ED) and/or were hospitalized following a suicide attempt, 2) identify factors associated with attempts requiring hospitalizations, and 3) validate the use of International Classification of Diseases, 10th Revision (ICD-10) codes for “intentional self-harm” as a method to detect suicide attempts from hospital abstract summary records. Method: All potential suicide attempts were identified from hospital abstract summary records and ED nursing triage file using ICD-10 codes and keywords suggestive of suicide attempts. All identified charts were examined, and those with confirmed suicide attempts were fully reviewed. Results: Of the 5746 identified charts, 369 were fully reviewed. Of these, 176 were for suicide attempters treated in the ED and 193 for hospitalized attempters, of whom 46% had an ICD-10 code for intentional self-harm. Poisoning (46%) was the most frequent method of suicide used. Half of attempters were younger than 34 years, 53% were female, and 75% had a history of mental disorders. Conclusion: About half of individuals who seek medical care for attempted suicide are admitted to hospital. About half of attempters use poisoning as a method of suicide, and a quarter do not have a history of mental disorders. Intentional self-harm codes capture only about half of hospitalized attempters.

A Literature Exercise Using Scifinder Scholar for the Sophomore-Level Organic Chemistry Course

ERIC Educational Resources Information Center

Rosenstein, Ian J.

2005-01-01

An exercise developed for use in the sophomore organic course that introduces students to the process of searching "Chemical Abstracts" with SciFinder Scholar using chiral auxiliaries as example compounds is described. The exercise provides a direct introduction to the chemical literature for students at an early stage of their undergraduate…

Promoting Great Teaching. 1982 Institute on Staff Development Proceedings (Austin, Texas, May 25-28, 1982).

ERIC Educational Resources Information Center

Baker, George A.; And Others

Full texts and abstracts of conference presentations are provided in the proceedings of the 1982 National Institute for Staff and Organizational Development conference held to celebrate and promote teaching excellence in the community college. After an introduction to the conference and its theme by George A. Baker, K. Patricia Cross, in a…

77 FR 73612 - Notice of Request for Extension of Approval of an Information Collection; Introduction of...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-11

... DEPARTMENT OF AGRICULTURE Animal and Plant Health Inspection Service [Docket No. APHIS-2012-0093.... Abstract: Under the Plant Protection Act (PPA, 7 U.S.C. 7701 et seq.), the Secretary of Agriculture is... dissemination of a plant pest into the United States. Under that authority, the U.S. Department of Agriculture's...

Multiscale Modeling of Graphite/CNT/Epoxy Hybrid Composites

DTIC Science & Technology

2016-03-09

A - Approved for Public Release 13. SUPPLEMENTARY NOTES 14. ABSTRACT Incorporation of carbon nanotubes (CNTs) into epoxy-based composites for...materials with higher moduli and strength characteristics. 15. SUBJECT TERMS Molecular Dynamics, Carbon Nanotubes , Multi-scale Modeling, Micromechanics...Gregory M. Odegard Michigan Technological University Introduction This project was inspired from the AFOSR-sponsored workshop “ Nanotube

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ward, R.C.

In this report, our research is described through abstracts of journal articles, technical reports, and presentations organized into sections following the five major operating units in the division: Mathematical Sciences, Intelligent Systems, Nuclear Data and Measurement Analysis, Nuclear Analysis and Shielding, and the Engineering Physics Information Centers. Each section begins with an introduction highlighting honors, awards, and significant research accomplishments in that unit during the reporting period.

An Exploration of a Genre Set: Research Article Abstracts and Introductions in Two Disciplines

ERIC Educational Resources Information Center

Samraj, Betty

2005-01-01

Disciplinary variation in academic writing has been explored for the most part by comparing a particular genre, such as the research article, across different disciplines. However, genre theorists have not systematically studied relationships among related genres. It is argued in this article that a study of relationships among related genres from…

A Research and Development Approach to the Delivery of Comprehensive Functional Education and Literacy in the Philippines.

ERIC Educational Resources Information Center

Doronila, Maria Luisa C.

In the Philippines, introduction of a formal education system, new written language, and the knowledge encoded in it have been part of a colonization process and not the result of direct evolution from informal education. The discontinuities between formal and informal education--abstraction, systematization, and specialization--are greater and…

Antimicrobial synergy of apple skin polyphenol and thyme essential oil in Açaí edible films and their effects on film properties (abstract)

USDA-ARS?s Scientific Manuscript database

Introduction: Diseases caused by food borne pathogens are of great concern to the food industry. The consumption of foods with chemical preservatives has led to increased consumer concern and demand for natural and minimally processed foods. In addition, environmental concerns are generated from cur...

Introduction to Classical Density Functional Theory by a Computational Experiment

ERIC Educational Resources Information Center

Jeanmairet, Guillaume; Levy, Nicolas; Levesque, Maximilien; Borgis, Daniel

2014-01-01

We propose an in silico experiment to introduce the classical density functional theory (cDFT). Density functional theories, whether quantum or classical, rely on abstract concepts that are nonintuitive; however, they are at the heart of powerful tools and active fields of research in both physics and chemistry. They led to the 1998 Nobel Prize in…

Evaluation of Biological and Male Reproductive Function Responses to Potential Lead Exposures in 155 mm Howitzer Crewmen

DTIC Science & Technology

1992-01-01

GROUP j SUB-GROUP Lead, Weapons Systems, Microwave Radiation, Male 16; 19 03 1 Reproductive Effects 17 10 19. ABSTRACT (Continue on reverse if... 1 INTRODUCTION ............ ................... 2 BACKGROUND ............................................... 4 EXPOSURE CHARACTERIZATION...APPENDIX C ............................................... 132 LIST OF FIGURES Figure 1 . Graphic representation for trend with respect to statistically

Nigeria: One Step Forward, Two Steps Back

DTIC Science & Technology

2012-11-02

the root causes of societal conflict. An analysis of the cultural and political identities of ethnicity, religion and regional affiliation provide a...governance. 15. SUBJECT TERMS Nigerian Culture and Society 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT 18. NUMBER OF PAGES...ii Contents Introduction 1 Section 1 Geographic impacts on Nigerian culture 1 Nigerian pre-independence history 3

Unit: Systems, Inspection Pack, National Trial Print.

ERIC Educational Resources Information Center

Australian Science Education Project, Toorak, Victoria.

This unit in the series prepared by the Australian Science Education Project is intended for students capable of abstract reasoning and as an introduction to other high level units in the series. The core activities suggest a number of activities that should lead students to recognize that a system is something that transforms an input into an…

PLAN COLOMBIA: Some Differing Perspectives

DTIC Science & Technology

2001-06-01

PLAN COLOMBIA Some Differing Perspectives Gabriel Marcella Charles E. Wilhelm Alvaro Valencia Tovar Ricardo Arias Calderón Chris Marquis June 2001...COLOMBIA: Some Differing Perspectives Contract or Grant Number Program Element Number Authors Gabriel Marcella ,Charles E. Wilhelm Alvaro Valencia...release, distribution unlimited Supplementary Notes ISBN 1-58487-057-5 Abstract This monograph, with an introduction by Dr. Gabriel Marcella

Expert Approaches to Analysis

DTIC Science & Technology

1999-03-01

of epistemic forms and games , which can form the basis for building a tool to support expert analyses. 15. SUBJECT TERMS Expert analysis Epistemic...forms Epistemic games SECURITY CLASSIFICATION OF 16. REPORT Unclassified 17. ABSTRACT Unclassified 18. THIS PAGE Unclassified 19. LIMITATION OF...1998 Principal Investigators: Allan Collins & William Ferguson BBN Technologies Introduction 1 Prior Work 2 Structural-Analysis Games 2 Functional

Board Games and Board Game Design as Learning Tools for Complex Scientific Concepts: Some Experiences

ERIC Educational Resources Information Center

Chiarello, Fabio; Castellano, Maria Gabriella

2016-01-01

In this paper the authors report different experiences in the use of board games as learning tools for complex and abstract scientific concepts such as Quantum Mechanics, Relativity or nano-biotechnologies. In particular we describe "Quantum Race," designed for the introduction of Quantum Mechanical principles, "Lab on a chip,"…

Microbial population analysis of broilers in different flock and embryonic ages from GI, yolk and egg wash via Illumina MiSeq and QIIME pipeline (abstract)

USDA-ARS?s Scientific Manuscript database

There are several food-safety issues related to broiler egg production, including the introduction/proliferation of zoonotic pathogens during embryonic gastrointestinal (GI) tract development. Little is known about the overall GI bacterial communities, how they change over time, or how their composi...

Superpowers Influence in the Horn of Africa

DTIC Science & Technology

1989-05-19

Greenfield: In its extent, its government and its problems, present day Ethiopia is largely the creaLion of the Emperor Menelik II . The process dating...conflict or cooperation between those involved during the next ten to fifteen years or so. 4 U / .- ii TABLE OF CONTENTS Page ABSTRACT... ii CHAPTER I. INTRODUCTION ..... ................. . . Survey of the Literature ..... ........... 3 Objective of the

Digital pathology imaging as a novel platform for standardization and globalization of quantitative nephropathology

PubMed Central

Gimpel, Charlotte; Kain, Renate; Laurinavicius, Arvydas; Bueno, Gloria; Zeng, Caihong; Liu, Zhihong; Schaefer, Franz; Kretzler, Matthias; Holzman, Lawrence B.; Hewitt, Stephen M.

2017-01-01

Abstract The introduction of digital pathology to nephrology provides a platform for the development of new methodologies and protocols for visual, morphometric and computer-aided assessment of renal biopsies. Application of digital imaging to pathology made substantial progress over the past decade; it is now in use for education, clinical trials and translational research. Digital pathology evolved as a valuable tool to generate comprehensive structural information in digital form, a key prerequisite for achieving precision pathology for computational biology. The application of this new technology on an international scale is driving novel methods for collaborations, providing unique opportunities but also challenges. Standardization of methods needs to be rigorously evaluated and applied at each step, from specimen processing to scanning, uploading into digital repositories, morphologic, morphometric and computer-aided assessment, data collection and analysis. In this review, we discuss the status and opportunities created by the application of digital imaging to precision nephropathology, and present a vision for the near future. PMID:28584625

Study on the Application of TOPSIS Method to the Introduction of Foreign Players in CBA Games

NASA Astrophysics Data System (ADS)

Zhongyou, Xing

The TOPSIS method is a multiple attribute decision-making method. This paper introduces the current situation of the introduction of foreign players in CBA games, presents the principles and calculation steps of TOPSIS method in detail, and applies it to the quantitative evaluation of the comprehensively competitive ability during the introduction of foreign players. Through the analysis of practical application, we found that the TOPSIS method has relatively high rationality and applicability when it is used to evaluate the comprehensively competitive ability during the introduction of foreign players.

The potential of using quantum theory to build models of cognition.

PubMed

Wang, Zheng; Busemeyer, Jerome R; Atmanspacher, Harald; Pothos, Emmanuel M

2013-10-01

Quantum cognition research applies abstract, mathematical principles of quantum theory to inquiries in cognitive science. It differs fundamentally from alternative speculations about quantum brain processes. This topic presents new developments within this research program. In the introduction to this topic, we try to answer three questions: Why apply quantum concepts to human cognition? How is quantum cognitive modeling different from traditional cognitive modeling? What cognitive processes have been modeled using a quantum account? In addition, a brief introduction to quantum probability theory and a concrete example is provided to illustrate how a quantum cognitive model can be developed to explain paradoxical empirical findings in psychological literature. © 2013 Cognitive Science Society, Inc.

Cancer and its Treatment in Main Ancient Books of Islamic Iranian Traditional Medicine (7th to 14th Century AD)

PubMed Central

Emami, Seyed Ahmad; Sahebkar, Amirhossein; Tayarani-Najaran, Nilufar; Tayarani-Najaran, Zahra

2012-01-01

Abstract Islamic medicine is regarded as a comprehensive medical school with a long, glorious and worldwide reputation. Some of the physicians of this school are famous worldwide and have contributed valuable services to the scientific world. Given the dramatically increasing prevalence of cancer and the relative inefficacy of current medications, there is a great demand for the introduction of effective therapeutic approaches. To this end, integration of traditional medicine with modern medical treatments represents a promising option. In this essay, methods of diagnosis and treatment of cancer have been mentioned from the viewpoint of five famous physicians before the Mongolian attack who used Islamic medicine, namely Rhazes, Akhaveyni, Ahwazi, Avicenna and Jorjani. The ideas discussed dates back to a period between the eighth and fourteenth centuries. PMID:23482830

African Primary Care Research: Writing a research report

PubMed Central

Mash, Bob

2014-01-01

Abstract Presenting a research report is an important way of demonstrating one's ability to conduct research and is a requirement of most research-based degrees. Although known by various names across academic institutions, the structure required is mostly very similar, being based on the Introduction, Methods, Results, Discussion format of scientific articles. This article offers some guidance on the process of writing, aimed at helping readers to start and to continue their writing; and to assist them in presenting a report that is received positively by their readers, including examiners. It also details the typical components of the research report, providing some guidelines for each, as well as the pitfalls to avoid. This article is part of a series on African Primary Care Research that aims to build capacity for research particularly at a Master's level. PMID:26245441

Temporal abstraction for the analysis of intensive care information

NASA Astrophysics Data System (ADS)

Hadad, Alejandro J.; Evin, Diego A.; Drozdowicz, Bartolomé; Chiotti, Omar

2007-11-01

This paper proposes a scheme for the analysis of time-stamped series data from multiple monitoring devices of intensive care units, using Temporal Abstraction concepts. This scheme is oriented to obtain a description of the patient state evolution in an unsupervised way. The case of study is based on a dataset clinically classified with Pulmonary Edema. For this dataset a trends based Temporal Abstraction mechanism is proposed, by means of a Behaviours Base of time-stamped series and then used in a classification step. Combining this approach with the introduction of expert knowledge, using Fuzzy Logic, and multivariate analysis by means of Self-Organizing Maps, a states characterization model is obtained. This model is feasible of being extended to different patients groups and states. The proposed scheme allows to obtain intermediate states descriptions through which it is passing the patient and that could be used to anticipate alert situations.

Determination of As, Se, and Hg in fuel samples by in-chamber chemical vapor generation ICP OES using a Flow Blurring® multinebulizer.

PubMed

García, Miriam; Aguirre, Miguel Ángel; Canals, Antonio

2017-09-01

In this work, a new and simple analytical methodology based on in-chamber chemical vapor generation has been developed for the spectrochemical analysis of commercial fuel samples. A multiple nebulizer with three nebulization units has been employed for this purpose: One unit was used for sample introduction, while the other two were used for the necessary reagent introduction. In this way, the aerosols were mixed inside the spray chamber. Through this method, analyte transport and, therefore, sensitivity are improved in inductively coupled plasma-optical emission spectrometry. The factors (i.e., variables), influencing chemical vapor generation, have been optimized using a multivariate approach. Under optimum chemical vapor generation conditions ([NaBH 4 ] = 1.39%, [HCl] = 2.97 M, total liquid flow = 936 μL min -1 ), the proposed sample introduction system allowed the determination of arsenic, selenium, and mercury up to 5 μg g -1 with a limit of detection of 25, 140, and 13 μg kg -1 , respectively. Analyzing spiked commercial fuel samples, recovery values obtained were between 96 and 113%, and expanded uncertainty values ranged from 4 to 16%. The most striking practical conclusion of this investigation is that no carbon deposit appears on the plasma torch after extended periods of working. Graphical abstract A new and simple analytical methodology based on in-chamber chemical vapor generation has been developed for the spectrochemical analysis of commercial fuel samples in ICP OES.

Advances in Flexible Hybrid Electronics Reliability

DTIC Science & Technology

2017-03-01

Advances in Flexible Hybrid Electronics Reliability Douglas R. Hackler, Richard L. Chaney, Brian N. Meek, Darrell E. Leber, Seth D. Leija, Kelly J...www.americansemi.com Abstract: Flexible Hybrid Electronics combine the best characteristics of printed electronics and silicon ICs to create high performance...presented for flexible hybrid electronics systems. Keywords: FleX; flexible; flexible hybrid electronics ; FHE; Silicon-on-Polymer Introduction

Cloud Fingerprinting: Using Clock Skews To Determine Co Location Of Virtual Machines

DTIC Science & Technology

2016-09-01

DISTRIBUTION CODE 13. ABSTRACT (maximum 200 words) Cloud computing has quickly revolutionized computing practices of organizations, to include the Department of... Cloud computing has quickly revolutionized computing practices of organizations, to in- clude the Department of Defense. However, security concerns...vi Table of Contents 1 Introduction 1 1.1 Proliferation of Cloud Computing . . . . . . . . . . . . . . . . . . 1 1.2 Problem Statement

Dextromethorphan Analogs: Receptor Binding and Pharmacological Profile of Novel Anticonvulsant/Neuroprotectant Drugs

DTIC Science & Technology

1993-05-13

AD-POO8 801 Dextromethorphan Analogs: Receptor Binding and Pharmacological Profile of Novel Anticonvulsant/Neuroprotective Drugs F.C. Tortella, L...Baltimore, MD 21224 CD ABSTRACT A series of 3-substituted 17-methylmorphinan analogs of dextromethorphan (DM) have open developed which are...nTTrTTn) INTRODUCTION The antitussives dextromethorphan (DM), caramiphen and carbetapentane have distinguished themselves as anticonvulsant drugs (1

Vertical Root Fracture Detection Using Limited-FOV Cone-Beam Computed Tomography

DTIC Science & Technology

2012-06-01

A thesis submitted to the Faculty of the Endodontics Graduate Program Naval Postgraduate Dental School Uniformed Services...Dental Program Navy Medicine Professional Development Center Terry D. Webb, DDS, MS CAPT, DC, USN Chairman, Endodontics Dept. Glen M. Imamura, S...Computed Tomography Geoffrey McMurray, DDS, MS ABSTRACT Introduction: Vertical root fractures (VRF) often occur in endodontically treated teeth

Augmentation of the Differentiation Response to Antitumor Antimalarials

DTIC Science & Technology

2004-07-01

Release; Distribution Unlimited 13. ABSTRACT (Maximum 200 Words) We have shown that the quinoline antimalarials chloroquine (CQ) and hydroxychloroquine (HCQ...Introduction: Preliminary studies showed that two of the quinoline antimalarials, chloroquine (CQ) and hydroxychloroquine (HCQ), displayed selective... hydroxychloroquine upon pretreatment with ATRA or Aza on tumor cell survival (Figures 1 and 2, respectively). Clonogenic survival of MDA-MB-231 cells exposed to

Writing Cancer Grant Applications | Center for Cancer Research

Cancer.gov

This course focuses on how to write clear and persuasive grant applications. The purpose is to increase the quality of your grant application by successfully communicating scientific data and ideas. Emphasis is placed on how to use the title abstract and introduction sections to draw in reviewers and how to write an organized and focused proposal using specific scientific aims.

Alcohol and Other Drug Use: The Connection to Youth Suicide. Abstracts of Selected Research.

ERIC Educational Resources Information Center

Laws, Kathy; Turner, Amy

This publication provides the reader with an overview of the research done on the connection between the use of alcohol and other drugs and the ideation and/or completion of suicide among adolescents. It also provides information and resources on how to develop a youth suicide prevention program. The introduction gives a brief overview of the…

Seismic Data Preparation Procedures

DTIC Science & Technology

1977-10-20

H. Swindell, and D. Sun. I’ I,,. - - _ _ _ _ - - I I j TABLE OF CONTENTS I SECTION TITLE PAGE ABSTRACT iii ACKNOWLEDGMENTS iv F I. INTRODUCTION I...followed by 4 bits of zero padding Bit 0 = 1 if i n s t rument 1 is bad Bit 1 = 1 if i n s t rumen t 2 is bad Bit ?. 1 if i n s t rument 3 is

Microbial Methane Fermentation Kinetics for Toxicant Exposure.

DTIC Science & Technology

1981-08-31

percent of digester contents daily. Bauchcp (1967) used chloroform as a specific inhibitor for methane formation in suspensions of rumen fluid. Other...washout. -wt 113 ,YO. it i L ,. . , . . . - _ TABLE OF CONTENTS I temn Page ABSTRACT................ . . ...... . ... .. .. .. .. .. .. .. INTRODUCTION...several environmental factors (McCarty, 1964; Dague, 1968; Metcalf and Eddy, 1979). The reactor contents should be free of dis- solved oxygen and other

GROUNDWARS 4.2 Reference Guide

DTIC Science & Technology

1991-12-01

land duel , homogeneous forces, TANKWARS, target acquisition, combat survivability 19. ABSTRACT (Continue on reverse if necessary and identify by block...number) GROUNDWARS is a stochastic, two-sided, event-sequenced weapon systems effectiveness model which provides the results of a land duel between two...GROUNDWARS 4.2 REFERENCE GUIDE I. INTRODUCTION Groundwars is a weapon systems effectiveness model which provides the results of a land duel between

The Linguistic Representation of Rhetorical Function: A Study of How Economists Present Their Knowledge Claims

ERIC Educational Resources Information Center

Dahl, Trine

2009-01-01

This article deals with how economists present their new knowledge claim in the genre of the research article. In the discipline of economics today, the claim is typically included not only in the obvious results/discussion section(s) but also in three other locations of the article: the abstract, the introduction, and the conclusion. The present…

JaK/STAT Inhibition to Prevent Post-Traumatic Epileptogenesis

DTIC Science & Technology

2014-09-01

Distribution Unlimited 13. SUPPLEMENTARY NOTES 14. ABSTRACT Traumatic Brain Injury (TBI) is a well-established inducer of temporal lobe epilepsy (TLE...INTRODUCTION: This research addresses the FY10 PRMRP topic area of Epilepsy . Traumatic Brain Injury (TBI) is a well- established etiology of temporal ... lobe epilepsy (TLE), a frequently medically intractable and often progressive epilepsy syndrome. Much evidence indicates that abnormalities in

Service Without Servers

DTIC Science & Technology

1993-08-01

Abstract We propose a new style of operating system architecture appropriate for microkernel -based operating sys- tems: services are implemented as a...retaining all the modularity advantages of microkernel technology. Since services reside in libraries, an application is free to use the library that...U.S. Government. 93-23976,. . I~lUI5E NIIA Keywords: Operating Systems, Microkernel , Network communication, File organization 1. Introduction In the

Polyamine Analogues as Novel Anti-HER Family Agents in Human Breast Cancer

DTIC Science & Technology

2008-09-01

Distribution Unlimited 13. SUPPLEMENTARY NOTES 14. ABSTRACT Elevated levels of all three naturally occurring polyamines, spermine, spermidine ...11 Appendices����������������������������� N/A 4 INTRODUCTION The polyamines, spermine, spermidine and

Integrative Cardiac Health Project, Windber Research Institute

DTIC Science & Technology

2015-07-01

ABSTRACT There is an increasing prevalence of obesity and cardiovascular disease (CVD) risk factors in the military population, which is negatively...and integrate information on dietary , behavioral, and lifestyle factors to provide important information on CVD risk reduction and (2) discover new...Outcomes 30 9. Other Achievements 30 10. References 30 11. Appendices 30 1. INTRODUCTION: There is an increasing prevalence of obesity and

Practice‐based Research Network Research Good Practices (PRGPs): Summary of Recommendations

PubMed Central

Campbell‐Voytal, Kimberly; Daly, Jeanette; Nagykaldi, Zsolt J.; O'Beirne, Maeve; Sterling, Pamela; Fagnan, Lyle J.; Levy, Barcey; Michaels, LeAnn; Louks, Hannah A.; Smith, Paul; Aspy, Cheryl B.; Patterson, V. Beth; Kano, Miria; Sussman, Andrew L.; Williams, Robert; Neale, Anne Victoria

2015-01-01

Abstract Introduction Practice‐based research networks (PBRNs) conduct research in community settings, which poses quality control challenges to the integrity of research, such as study implementation and data collection. A foundation for improving research processes within PBRNs is needed to ensure research integrity. Methods Network directors and coordinators from seven U.S.‐based PBRNs worked with a professional team facilitator during semiannual in‐person meetings and monthly conference calls to produce content for a compendium of recommended research practices specific to the context of PBRNs. Participants were assigned to contribute content congruent with their expertise. Feedback on the draft document was obtained from attendees at the preconference workshop at the annual PBRN meeting in 2013. A revised document was circulated to additional PBRN peers prior to finalization. Results The PBRN Research Good Practices (PRGPs) document is organized into four chapters: (1) Building PBRN Infrastructure; (2) Study Development and Implementation; (3) Data Management, and (4) Dissemination Policies. Each chapter contains an introduction, detailed procedures for each section, and example resources with information links. Conclusion The PRGPs is a PBRN‐specific resource to facilitate PBRN management and staff training, to promote adherence to study protocols, and to increase validity and generalizability of study findings. PMID:26296309

Environmentally conscious alternative energy production

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kutz, M.

This fourth volume of the series describes and compares the environmental and economic impacts of renewable and conventional power generation technologies. Chapter heading are: Economic comparisons of power generation technologies (Todd Nemec); Solar energy applications (Jan F. Kreider); Fuel cells (Matthew W. Mench); Geothermal resources and technology: an introduction (Peter D. Blair); Wind power generation (Todd Nemec); Cogeneration (Jerald Caton); Hydrogen energy (Elias K. Stefanakos, Yogi Goswami, S.S. Srinivasan, and J.T. Wolan); Clean power generation from coal (Prabir Basu and James Butler); and Using waste heat from power plants (Herbert A. Ingley). The chapter on clean coal power generation frommore » coal has been abstracted separately on the Coal Abstracts database. 2 apps.« less

Concrete Model Checking with Abstract Matching and Refinement

NASA Technical Reports Server (NTRS)

Pasareanu Corina S.; Peianek Radek; Visser, Willem

2005-01-01

We propose an abstraction-based model checking method which relies on refinement of an under-approximation of the feasible behaviors of the system under analysis. The method preserves errors to safety properties, since all analyzed behaviors are feasible by definition. The method does not require an abstract transition relation to he generated, but instead executes the concrete transitions while storing abstract versions of the concrete states, as specified by a set of abstraction predicates. For each explored transition. the method checks, with the help of a theorem prover, whether there is any loss of precision introduced by abstraction. The results of these checks are used to decide termination or to refine the abstraction, by generating new abstraction predicates. If the (possibly infinite) concrete system under analysis has a finite bisimulation quotient, then the method is guaranteed to eventually explore an equivalent finite bisimilar structure. We illustrate the application of the approach for checking concurrent programs. We also show how a lightweight variant can be used for efficient software testing.

Multiple Introductions of Dengue 2 Virus Strains into Saudi Arabia from 1992 to 2014

PubMed Central

El-Kafrawy, Sherif A.; Sohrab, Sayed S.; Ela, Said Abol; Abd-Alla, Adly M.M.; Alhabbab, Rowa; Farraj, Suha A.; Othman, Norah A.; Hassan, Ahmed M.; Bergoin, Max; Klitting, Raphaelle; Charrel, Remi N.; Hashem, Anwar M.; Madani, Tariq A.

2016-01-01

Abstract Introduction: Dengue is a significant arboviral infection that represents a major public health concern worldwide. The infection is endemic in most parts of South East Asia, sub-Saharan Africa, and Latin America. Among the four dengue virus (DENV) serotypes, DENV-2 has been reported to be the predominant serotype in Saudi Arabia since 1992. However, virological and epidemiological data of DENV-2 from Saudi Arabia are severely deficient and require further investigations. Methods: Full genome sequencing of a recent DENV-2 isolate and phylogenetic analysis of all available DENV-2 sequences from Saudi Arabia. Results: Based on full genome and envelope (E) gene sequence, we show that a recent isolate (DENV-2-Jeddah-2014) belongs to the Indian subcontinent lineage of the Cosmopolitan genotype with close similarity to recent strains from Pakistan. Interestingly, the E gene sequence of DENV-2-Jeddah-2014 isolate was slightly divergent from those previously identified in Saudi Arabia between 1992 and 2004 with three to nine amino acid (aa) substitutions. While our data show that the Cosmopolitan genotype is still circulating in Saudi Arabia, they highlight four distinct genetic groups suggesting at least four independent introductions into the Kingdom. Conclusions: The close clustering of DENV-2 isolates reported from Saudi Arabia between 1992 and 2014 with strains from countries providing the highest numbers of pilgrims attending either Hajj or Umrah pilgrimages (Indonesia, Pakistan, India) clearly suggests a role for pilgrims or expatriates coming from DENV endemic countries in DENV-2 importation into Saudi Arabia. Accordingly, continuous monitoring of the circulation of DENVs in Saudi Arabia must be implemented to undertake effective control and management strategies in the Kingdom. Screening of the pilgrims coming to perform Hajj and Umrah might help prevent the introduction of new DENV strains, which is expected to increase the burden of the disease not only in Saudi Arabia but also in other countries. PMID:27135750

A Guide to Writing a Scientific Paper: A Focus on High School Through Graduate Level Student Research

PubMed Central

Petering, David H.; Berg, Craig A.; Tomasiewicz, Henry; Weber, Daniel

2012-01-01

Abstract This article presents a detailed guide for high school through graduate level instructors that leads students to write effective and well-organized scientific papers. Interesting research emerges from the ability to ask questions, define problems, design experiments, analyze and interpret data, and make critical connections. This process is incomplete, unless new results are communicated to others because science fundamentally requires peer review and criticism to validate or discard proposed new knowledge. Thus, a concise and clearly written research paper is a critical step in the scientific process and is important for young researchers as they are mastering how to express scientific concepts and understanding. Moreover, learning to write a research paper provides a tool to improve science literacy as indicated in the National Research Council's National Science Education Standards (1996), and A Framework for K–12 Science Education (2011), the underlying foundation for the Next Generation Science Standards currently being developed. Background information explains the importance of peer review and communicating results, along with details of each critical component, the Abstract, Introduction, Methods, Results, and Discussion. Specific steps essential to helping students write clear and coherent research papers that follow a logical format, use effective communication, and develop scientific inquiry are described. PMID:23094692

Introduction to Design and Analysis of High Speed Pumps

DTIC Science & Technology

2006-11-01

for public release, distribution unlimited 13 . SUPPLEMENTARY NOTES See also ADM002051., The original document contains color images. 14. ABSTRACT 15...fluctuations in the pump and the installation, vibration and noise). Figure ( 13 ) presents schematically, for a meridional section in a radial flow pump...impeller. Figure (14) illustrates what can be observed in different types of pumps when recirculation is present. Figure 13 : Schematic Illustration

High Temperature Hot Corrosion Control by Fuel Additives (Contaminated Fuels).

DTIC Science & Technology

1987-06-01

ABSTRACT The potential of fuel additives to minimize corrosion of blade material in gas turbine engines has been analyzed by the following series of steps...INTRODUCTION High chrome steels and superalloys, which are used extensively for high temperature boilers and gas turbine (GT) engines and related...combustion gases onto turbine blades and other hot components. Among the factors expected to affect the corrosion resis

Effects of introduced small wood in a degraded stream on fish community and functional diversity

Treesearch

Ken A. Sterling; Melvin L.  Warren Jr.

2018-01-01

Abstract - Though the effects of introduced wood on fishes is widely studied for salmonids in upland coldwater streams, there are few studies on this topic conducted in the Coastal Plain of the southeastern US. This research gap is problematic because the introduction of wood is a critical component of efforts aimed at conserving the threatened fish diversity of the...

Collaborative Model for Acceleration of Individualized Therapy of Colon Cancer

DTIC Science & Technology

2015-12-01

Approved for Public Release; Distribution Unlimited 13. SUPPLEMENTARY NOTES 14. ABSTRACT Colorectal cancer (CRC) represents a major health burden...15. SUBJECT TERMS Colorectal cancer, novel anti-cancer agents, bioinformatics, next-generation sequencing, predictive biomarkers, individualized...INTRODUCTION:   Colorectal   cancer   (CRC)   represents   a  major   health  burden,   and   is   the   third   leading

Summary of Selected State Licensing Requirements: Day Care Centers, Family Day Care Homes. Day Care Survey--1970. Preliminary Edition.

ERIC Educational Resources Information Center

Office of Economic Opportunity, Washington, DC. Evaluation Div.

This volume of abstracts of child day care facility licensing requirements is intended to serve as an introduction to selected aspects of the licensing process within the several states by reviewing (1) the various definitions of day care facilities in the jurisdictions covered, and (2) the prescribed regulations established by the states to…

Testing Brain Overgrowth and Synaptic Models of Autism Using NPC’s and Neurons from Patient-Derived IPS Cells

DTIC Science & Technology

2014-10-01

Release; Distribution Unlimited 13. SUPPLEMENTARY NOTES 14. ABSTRACT Autism and autism spectrum disorders (ASD) are complex neurodevelopmental ...1. INTRODUCTION: Autism and autism spectrum disorders (ASD) are complex neurodevelopmental diseases that affect about 1% of children in the...and neurons. 2. KEYWORDS: Autism spectrum disorder, ASD, neurodevelopmental disease, disease modeling, induced pluripotent stem cell, iPS

Variable Discretisation for Anomaly Detection using Bayesian Networks

DTIC Science & Technology

2017-01-01

UNCLASSIFIED DST- Group –TR–3328 1 Introduction Bayesian network implementations usually require each variable to take on a finite number of mutually...UNCLASSIFIED Variable Discretisation for Anomaly Detection using Bayesian Networks Jonathan Legg National Security and ISR Division Defence Science...and Technology Group DST- Group –TR–3328 ABSTRACT Anomaly detection is the process by which low probability events are automatically found against a

A Comprehensive Web-Based Patient Information Environment

DTIC Science & Technology

2001-10-25

hospitals. Keywords - I. INTRODUCTION This paper describes a comprehensive, web-enabled, patient - centric medical information system called PiRiLiS...clinically focused. The system was found to reduce time for medical administration. The ability to view the entire patient record at anytime, anywhere in...Abstract- The paper describes a new type of medical information environment which is fully web-enabled. The system can handle any type medical

Cloning and Characterization of a Cell Senescence Gene for Breast Cancer Cells

DTIC Science & Technology

2004-07-01

have already established the inducible expression system in a retroviral vector for these studies. F. References 1. Hayflick , L. (1965). The limited ...CLASSIFICATION 18. SECURITY CLASSIFICATION 19. SECURITY CLASSIFICATION 20. LIMITATION OF ABSTRACT OF REPORT OF THIS PAGE OFABSTRACT Unclassified...13-14 Annual report A. Introduction Normal diploid mammalian cells display a limited proliferative life span in culture (1-3

30MM GAU-8/A Plastic Frangible Projectile

DTIC Science & Technology

1977-03-01

20. ABSTRACT fContlnuo on rmvert» tld» 11 nacaaaary and Idontlly by block numbmr) ■feA 30mm target practice (TP) projectile, designed to break...contract to solve these problems. As a result, the Air Force has decided to delay further development of this projectile design concept...Section Title I INTRODUCTION II TECHNICAL DISCUSSION Design Parameters Final Projectile Design Design Evolution Acceptance Testing III

SEPG Europe 2012 Conference Proceedings

DTIC Science & Technology

2012-09-01

Process Management http://www.sei.cmu.edu SEI markings v3.2/ DM-0000022 / 30 August 2011 Copyright 2012 Carnegie Mellon University This material...Change Management Decisions in Large Enterprise Transformation Programs 18 3.1 Abstract 18 3.2 Introduction 18 3.3 Barriers for Transformation 18...Case Study #3: Enterprise Transformation Through Enterprise Data Management (Investment and Asset Management ) 25 3.7 Conclusions and Recommendations 27

Nonlinear Real-Time Optical Signal Processing.

DTIC Science & Technology

1981-06-30

bandwidth and space-bandwidth products. Real-time homonorphic and loga- rithmic filtering by halftone nonlinear processing has been achieved. A...Page ABSTRACT 1 1. RESEARCH OBJECTIVES AND PROGRESS 3 I-- 1.1 Introduction and Project overview 3 1.2 Halftone Processing 9 1.3 Direct Nonlinear...time homomorphic and logarithmic filtering by halftone nonlinear processing has been achieved. A detailed analysis of degradation due to the finite gamma

Analysis of Time Dependent Electric Field Degradation in AlGaN/GaN HEMTs (POSTPRINT)

DTIC Science & Technology

2014-10-01

identifying and understanding the failure mechanisms that limit the safe operating area of GaN HEMTs. 15. SUBJECT TERMS aluminum gallium nitride... gallium nitride, HEMTs, semiconductor device reliability, transistors 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT SAR 18. NUMBER...area of GaN HEMTs. Index Terms— Aluminum gallium nitride, gallium nitride, HEMTs, semiconductor device reliability, transistors. I. INTRODUCTION A

Antingens for a Vaccine that Prevents Severe Malaria

DTIC Science & Technology

2009-03-01

SUPPLEMENTARY NOTES 14. ABSTRACT Malaria is the primary infectious disease threat facing the U.S. soldier, and is the leading cause of all...causalities during tropical deployments. The long-term objective of this project is to identify and prepare the malaria parasite forms causing severe...17-50 INTRODUCTION: Malaria is the primary infectious disease threat facing the U.S. solider, and is the leading cause of all

Global Behavior in Large Scale Systems

DTIC Science & Technology

2013-12-05

release. AIR FORCE RESEARCH LABORATORY AF OFFICE OF SCIENTIFIC RESEARCH (AFOSR)/RSL ARLINGTON, VIRGINIA 22203 AIR FORCE MATERIEL COMMAND AFRL-OSR-VA...and Research 875 Randolph Street, Suite 325 Room 3112, Arlington, VA 22203 December 3, 2013 1 Abstract This research attained two main achievements: 1...microscopic random interactions among the agents. 2 1 Introduction In this research we considered two main problems: 1) large deviation error performance in

The Influence on Microstructure and Microtexture on Fatigue Crack Initiation and Growth in Alpha + Beta Titanium

DTIC Science & Technology

2011-10-01

crack growth, microstructure, EBSD, fractography 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT: SAR NUMBER OF PAGES 6 19a...differences in thermomechanical processing routes have been correlated with variations in fatigue life through the use of quantitative fractography ...Keywords: fatigue, crack initiation, crack growth, microstructure, EBSD, fractography 1. Introduction Two-phase titanium alloys have the unique

Performance of the Tin-Free Antifouling Coating International Ecoloflex in DSTO/RAN Trials

DTIC Science & Technology

2008-10-01

Science and Technology Organisation DSTO-TR-2203 ABSTRACT A national and global ban on the application of antifouling paints containing tributyltin (TBT...Ecoloflex in DSTO/RAN Trials Executive Summary The antifouling biocide tributyltin (TBT) has provided the most effective means of preventing fouling...24 DSTO-TR-2203 1. Introduction Antifouling paints containing tributyltin (TBT) as the primary biocide were

Studies of Collisional and Nonlinear Radiative Processes for Development of Coherent UV and XUV Sources

DTIC Science & Technology

1991-06-04

Rhodes CO-INVESTIGATORS: Ting Shan Luk Armon McPherson Keith Boyer PROGRAM MANAGER: Dr. Howard Schlossberg Air Force Office of Scientific Research /NP...Scientific Research Boiling Air Force Base Washington, D. C. 20332-6448 e92-19919 Pr ,’ted on O % ,ecyc~ed pe TABLE OF CONTENTS ABSTRACT...1 1. INTRODUCTION .......... ........................... 2 II. GENERAL DISCUSSION OF RESEARCH ....... ................ 2 A

Reliability: A Comparison of Absence Measures.

DTIC Science & Technology

1985-09-01

28 8. Sick Leave Frequency Index ... . .. . . . . . . . 29 J.v -. ~~~~i j.- .i...- - AFIT/GSM/LSB/85S-19 Abstract Absenteeism is an important and...RELIABILITY: A COMPARISON OF ABSENCE MEASURES I. Literature Review Introduction Absenteeism may be defined as undesired work absence. This withdrawal...behavior is an important organizational problem because of probable reduced labor productivity and increased training costs. * Absenteeism is almost

Effectiveness and Predictability of Particle Damping

DTIC Science & Technology

2000-01-01

Design Methodology for Extreme Environments,” Contract No. F33615-98-C-3005. The authors gratefully acknowledge the support and guidance of Mr. Robert...Mountain View, CA 94043 b University of Dayton Research Institute, 300 College Park, Dayton, OH 45469 ABSTRACT In this paper, recent results of...has been developed in support of this work. Keywords: Nonlinear, Particle, Granular, Impact, Damping 1. INTRODUCTION Particle damping is a derivative

FES-Rowing versus Zoledronic Acid to Improve Bone Health in SCI

DTIC Science & Technology

2015-10-01

although the risk is high in this population of osteoporosis -related bone fracture. This study aims to learn if the severe osteoporosis in lower... Osteoporosis , FES-rowing, zoledronic acid, exercise, bone health 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT 18. NUMBER OF PAGES 19a...9 Introduction Serious spinal cord injury (SCI) causes osteoporosis in the lower extremities, significantly increasing

Development of a Specific Impulse Balance for a Pulsed Capillary Discharge (Preprint)

DTIC Science & Technology

2008-06-13

thrust stand [rad/s] I. Introduction A capillary discharge based coaxial , electrothermal pulsed plasma thruster (PPT) is currently under...20-23 July 2008. 14. ABSTRACT A capillary discharge based pulsed plasma thruster is currently under development at the Air Force Research...Edwards AFB, CA 93524 A capillary discharge based pulsed plasma thruster is currently under development at the Air Force Research Laboratory. A

Reactions Between Contaminants and Functionalized Organic Self-Assembled Monolayers in Aqueous Solutions

DTIC Science & Technology

2006-05-16

Documentation Page Form ApprovedOMB No. 0704-0188 Public reporting burden for the collection of information is estimated to average 1 hour per response, including...DISTRIBUTION/AVAILABILITY STATEMENT Approved for public release; distribution unlimited 13. SUPPLEMENTARY NOTES 14. ABSTRACT The interaction of...Introduction The subject of microbiological contamination in water has long been a major public concern, where microorganisms such as coliform bacteria

Generic and Automated Runtime Program Repair

DTIC Science & Technology

2012-09-01

other person or corporation; or convey any rights or permission to manufacture, use, or sell any patented invention that may relate to them... PERSON PATRICK M. HURLEY a. REPORT U b. ABSTRACT U c. THIS PAGE U 19b. TELEPONE NUMBER (Include area code) N/A Standard Form 298...Public Release; Distribution Unlimited. 2. Introduction Software bugs are ubiquitous, and fixing them remains a difficult, time- consuming , and manual

Chemistry Teachers' Journey through Modeling Instruction: From Workshop to Classroom

NASA Astrophysics Data System (ADS)

Frick, Tasha

This presentation will feature case study research that describes the difficulties that four high school chemistry teachers faced while implementing Modeling Instruction into their classrooms. Modeling Instruction is characterized by the development of understanding through cooperative inquiry and collective discourse on a path from concrete to abstract. The complications in transforming a classroom from traditional teacher centered methods to one which focuses on the use of student-centered Modeling Instruction will be thoroughly investigated through the stories of each of the participants. The study begins with observations of the teachers prior to the introduction of Modeling Instruction and follows them into the professional development in the summer, the initial use in the fall term, a follow-up workshop, and finally back into the classrooms. The enlightening findings highlight the difficulties teachers had in aligning the standards, and developing a scope and sequence, as well as reconciling their beliefs about student ability.

Orthodontic camouflage of skeletal Class III malocclusion with miniplate: a case report

PubMed Central

Farret, Marcel Marchiori; Farret, Milton M. Benitez; Farret, Alessandro Marchiori

2016-01-01

ABSTRACT Introduction: Skeletal Class III malocclusion is often referred for orthodontic treatment combined with orthognathic surgery. However, with the aid of miniplates, some moderate discrepancies become feasible to be treated without surgery. Objective: To report the case of a 24-year-old man with severe skeletal Angle Class III malocclusion with anterior crossbite and a consequent concave facial profile. Methods: The patient refused to undergo orthognathic surgery; therefore, orthodontic camouflage treatment with the aid of miniplates placed on the mandibular arch was proposed. Results: After 18 months of treatment, a Class I molar and canine relationship was achieved, while anterior crossbite was corrected by retraction of mandibular teeth. The consequent decrease in lower lip fullness and increased exposure of maxillary incisors at smiling resulted in a remarkable improvement of patient's facial profile, in addition to an esthetically pleasing smile, respectively. One year later, follow-up revealed good stability of results. PMID:27653269

TOMOGRAPHIC MORPHOLOGICAL STUDY OF THE CRANIUM AND ITS CORRELATION WITH CRANIAL HALO USE IN ADULTS

PubMed Central

ALMEIDA, TIAGO FERREIRA DE; CHARAFEDDINE, HOMAR TOLEDO; ARAÚJO, FERNANDO FLORES DE; CRISTANTE, ALEXANDRE FOGAÇA; MARCON, RAPHAEL MARTUS; LETAIF, OLAVO BIRAGHI

2017-01-01

ABSTRACT Objective: To evaluate using tomographic study the thickness of the cranial board at the insertions points of the cranial halo pins in adults Methods: This is a retrospective, cross-sectional, descriptive analysis of Computed Tomography (CT) scans of adult patients' crania. The study included adults between 20 and 50 years without cranial abnormalities. We excluded any exam with cranial abnormalities Results: We analyzed 50 CT scans, including 27 men and 23 women, at the original insertion points and alternative points (1 and 2 cm above the frontal and parietal bones). The average values were 7.4333 mm in the frontal bone and 6.0290 mm in the parietal bone Conclusion: There was no statistically significant difference between the classical and alternative points, making room for alternative fixings and safer introduction of the pins, if necessary.Level of Evidence II, Retrospective Study. PMID:28642643

A systematic review of health economic evaluations of vaccines in Brazil

PubMed Central

2017-01-01

ABSTRACT Background: In Brazil, since 2005, the Ministry of Health requires Health Economic Evaluation (HEE) of vaccines for introduction into the National Immunization Program. Objectives: To describe and analyze the full HEE on vaccines conducted in Brazil from 1980 to 2013. Methods: Systematic review of the literature. We searched multiple databases. Two researchers independently selected the studies and extracted the data. The methodological quality of individual studies was evaluated using CHEERS items. Results: Twenty studies were reviewed. The most evaluated vaccines were pneumococcal (25%) and HPV (15%). The most used types of HEE were cost-effectiveness analysis (45%) and cost-utility analysis (20%). The research question and compared strategies were stated in all 20 studies and the target population was clear in 95%. Nevertheless, many studies did not inform the perspective of analysis or data sources. Conclusions: HEE of vaccines in Brazil has increased since 2008. However, the studies still have methodological deficiencies. PMID:28129026

Single-cell RNA-sequencing: The future of genome biology is now

PubMed Central

Picelli, Simone

2017-01-01

ABSTRACT Genome-wide single-cell analysis represents the ultimate frontier of genomics research. In particular, single-cell RNA-sequencing (scRNA-seq) studies have been boosted in the last few years by an explosion of new technologies enabling the study of the transcriptomic landscape of thousands of single cells in complex multicellular organisms. More sensitive and automated methods are being continuously developed and promise to deliver better data quality and higher throughput with less hands-on time. The outstanding amount of knowledge that is going to be gained from present and future studies will have a profound impact in many aspects of our society, from the introduction of truly tailored cancer treatments, to a better understanding of antibiotic resistance and host-pathogen interactions; from the discovery of the mechanisms regulating stem cell differentiation to the characterization of the early event of human embryogenesis. PMID:27442339

UAS Conflict-Avoidance Using Multiagent RL with Abstract Strategy Type Communication

NASA Technical Reports Server (NTRS)

Rebhuhn, Carrie; Knudson, Matt; Tumer, Kagan

2014-01-01

The use of unmanned aerial systems (UAS) in the national airspace is of growing interest to the research community. Safety and scalability of control algorithms are key to the successful integration of autonomous system into a human-populated airspace. In order to ensure safety while still maintaining efficient paths of travel, these algorithms must also accommodate heterogeneity of path strategies of its neighbors. We show that, using multiagent RL, we can improve the speed with which conflicts are resolved in cases with up to 80 aircraft within a section of the airspace. In addition, we show that the introduction of abstract agent strategy types to partition the state space is helpful in resolving conflicts, particularly in high congestion.

Botulinum toxin A in the treatment of Raynaud's phenomenon: a systematic review

PubMed Central

Puszczewicz, Mariusz J.

2015-01-01

Introduction The management of Raynaud's phenomenon in its most severe form is challenging, and current medical and surgical treatment methods frequently do not lead to optimal symptom control and prevention of ischemic complications. The aim of the study was to critically evaluate all existing evidence on the use of botulinum toxin A in the management of Raynaud's phenomenon. Material and methods We adopted the PRISMA methodology and searched Cochrane Library, MEDLINE, SCOPUS, EULAR and ACR congresses abstract archives for Raynaud* AND botulinum toxin OR onabotulinum. All studies that contained reports of botulinum toxin A use and its outcome in Raynaud's phenomenon were included in the review. Results Eleven studies met our inclusion criteria and involved a total of 125 patients. Two reviewers extracted data from the studies under review and achieved a consensus in their selection. The main outcomes measured were pain reduction and healing of digital ulcers. The level of evidence across studies was very low to moderate. Conclusions There is insufficient evidence to assess the efficacy of botulinum toxin A in Raynaud's phenomenon. Despite many promising reports, further research in the form of randomized controlled trials is warranted in order to investigate this new treatment method for Raynaud's phenomenon. PMID:27478469

Quality of care for patients with diabetes mellitus type 2 in ‘model practices’ in Slovenia – first results

PubMed Central

Mlakar, Mitja

2016-01-01

Abstract Background A new organisation at the primary level, called model practices, introduces a 0.5 full-time equivalent nurse practitioner as a regular member of the team. Nurse practitioners are in charge of registers of chronic patients, and implement an active approach into medical care. Selected quality indicators define the quality of management. The majority of studies confirm the effectiveness of the extended team in the quality of care, which is similar or improved when compared to care performed by the physician alone. The aim of the study is to compare the quality of management of patients with diabetes mellitus type 2 before and after the introduction of model practices. Methods A cohort retrospective study was based on medical records from three practices. Process quality indicators, such as regularity of HbA1c measurement, blood pressure measurement, foot exam, referral to eye exam, performance of yearly laboratory tests and HbA1c level before and after the introduction of model practices were compared. Results The final sample consisted of 132 patients, whose diabetes care was exclusively performed at the primary care level. The process of care has significantly improved after the delivery of model practices. The most outstanding is the increase of foot exam and HbA1c testing. We could not prove better glycaemic control (p>0.1). Nevertheless, the proposed benchmark for the suggested quality process and outcome indicators were mostly exceeded in this cohort. Conclusion The introduction of a nurse into the team improves the process quality of care. Benchmarks for quality indicators are obtainable. Better outcomes of care need further confirmation. PMID:27703537

Branch Detonation of a Pulse Detonation Engine With Flash Vaporized JP-8

DTIC Science & Technology

2006-12-01

Mark F. Reeder (Member) date iii Abstract Pulse Detonation Engines ( PDE ) operating on liquid hydrocarbon fuels are... Detonation Transition FF – Fill Fraction FN – Flow Number NPT – National Pipe Thread OH – Hydroxyl PDE – Pulse Detonation Engine PF – Purge...Introduction Motivation Research on Pulsed Detonation Engines ( PDE ) has increased over the past ten years due to the potential for increased

Room Temperature Erbium-Doped Yttrium Vanadate (Er:YVO4) Laser and Amplifier

DTIC Science & Technology

2016-09-01

perpendicular to the laser cavity axis, was pumped in σ-polarization and lased in π-polarization. The laser operated in a quasi -continuous wave regime...laser, amplifier, quasi -continuous wave 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT UU 18. NUMBER OF...distribution unlimited. iii Contents List of Figures iv 1. Introduction 1 2. Laser Experimental Setup and Results 2 3. Laser Amplifier Setup 6 4

Excessive Cap-dependent Translation as a Molecular Mechanism Underlying ASD

DTIC Science & Technology

2012-08-01

SUPPLEMENTARY NOTES 14. ABSTRACT We hypothesize that excessive cap-dependent translation is a causative factor in autism spectrum disorder...compounds to therapeutically target eIF4E-eIF4G interactions and eIF4A for treating patients with ASD. 15. SUBJECT TERMS autism spectrum...Introduction We hypothesize that excessive cap-dependent translation is a causative factor in autism spectrum disorder (ASD). To test this

Research Article Abstracts and Introductions: A Comparative Genre-Based Study of Arabic and English in the Fields of Educational Psychology and Sociology

ERIC Educational Resources Information Center

Alotaibi, Hmoud

2013-01-01

The genre of the research article has attracted the attention of researchers, particularly after the research conducted by Swales (1981). In 1990, Swales introduced the Create a Research Space (CARS) model which consists of three rhetorical moves (i.e. units): Move 1: creating a research territory, Move 2: establishing a niche, and Move 3:…

Identification of Novel Genes and Candidate Targets in CML Stem Cells

DTIC Science & Technology

2008-07-01

myeloblastosis viral oncogene homolog (avian) 6q22–q23 12 GATCCTGTGTTTGCAAC 1 FLI1 NM_002017 Friend leukemia virus integration 1 11q24.1–q24.3 3...AVAILABILITY STATEMENT Approved for public release; distribution unlimited 13. SUPPLEMENTARY NOTES 14. ABSTRACT Chronic myeloid leukemia (CML) is...Conclusion 6 References 6 Supporting Data 8 Appendices 16 4 INTRODUCTION: Chronic myeloid leukemia (CML) is a blood

Force Projection, Strategic Agility and the Big Meltdown

DTIC Science & Technology

2001-05-18

UNLIMITED Number of Pages 29 ii Abstract of FORCE PROJECTION, STRATEGIC AGILITY AND THE BIG MELTDOWN Due to global warming , the polar icepack which...INTRODUCTION The polar icecap which covers the Arctic Ocean is melting. It is a well-known, scientific fact. Global warming is the generally...operational factors and functions, as applicable. 3 CHAPTER II BACKGROUND Global Warming and the Arctic During this and the last century, researchers have

Mobile, Multi-modal, Label-Free Imaging Probe Analysis of Choroidal Oximetry and Retinal Hypoxia

DTIC Science & Technology

2016-10-01

Unlimited 13. SUPPLEMENTARY NOTES 14. ABSTRACT Coherent anti-stokes Raman spectroscopy ( CARS ) can be used to detect differences in the oxygen content...oxygen, eye, retina, photoreceptor, neuron, TRPM7, neurodegeneration, neurotoxicity, coherent anti-Stokes Raman spectroscopy, CARS , mouse 16...ANSI Std. Z39.18 Section 1: Introduction The study is based on the premise that Coherent Anti-Stokes Raman scattering ( CARS ) imaging provides a

Library Research in Criminal Justice. An Introduction for Students at John Jay College of Criminal Justice, City University of New York. Second Edition.

ERIC Educational Resources Information Center

Lutzker, Marilyn

This introductory guide to basic library research tools in the field of criminal justice was compiled for use by students at the John Jay College of Criminal Justice as part of the Library Instruction Program. Included are chapters on devising a search strategy; the use of the card catalog; encyclopedia and dictionaries; indexes and abstracts;…

A Retrospective Analysis of Initial Posterior Root Canal Therapy on United States Air Force Personnel

DTIC Science & Technology

2016-06-01

and John Yaccino, DDS Abstract Introduction: The Air Force Dental Service (AFDS) has established evidence-based treatment standards for endodontics...and cuspal coverage restorations (4-6). With this research, the Air Force Dental Service (AFDS) established evidence-based treatment standards for...endodontics to ensure Airmen receive high-quality, safe dental care (7). These standards are taught at the two Air Force (AF) Postgraduate Endodontic

Robust Computer-Assisted Laser Treatment Using Real-Time Retinal Tracking

DTIC Science & Technology

2001-10-25

Abstract- We propose a new computerized system to accurately guide laser shots to the diseased areas within the retina based on predetermined...image registration I. INTRODUCTION Diabetic retinopathy resulting from long term diabetes mellitus is one of the common diseases that lead to choroidal...have a strong impact on the effectiveness of such procedures. In this work, we propose a new computerized treatment planning system for laser treatment

Mechanical Testing of Silicon Carbide on MISSE-7

DTIC Science & Technology

2012-07-15

JS) ii Abstract Silicon carbide ( SiC ) mechanical test specimens were included on the second Optical and Reflector Materials Experiment (ORMatE II...2. Vendor 2 EFS Weibull Results (normalized to Extra Disks Weibull parameters) 12 1. Introduction Silicon carbide ( SiC ) mechanical test...AEROSPACE REPORT NO ATR-2012(8921)-5 Mechanical Testing of Silicon Carbide on MISSE-7 Jul> 15. 2012 David B. Witkin Space Materials Laboratory

Burn Enhances Toll-Like Receptor Induced Responses by Circulating Leukocytes

DTIC Science & Technology

2012-04-30

Introduction Major burn is associated with a local and sys- temic activation of the innate immune system resulting in a profound inflammatory...plications. Previous studies have shown that responses after burn differ between fixed-tissue immune cells and circulating immune cells [15]. In the current...Abstract: Burn and toll-like receptors (TLR) are associated with innate immune system activation, but the impact of burn on TLR-induced inflammation

Models of Cerebral-Body Perfusion and Cerebral Chemical Transport.

DTIC Science & Technology

1988-03-01

Pressure Waves 22 Conchusion 23 References 36 A Compartmental Brain Model for Chemical Transport and CO2 Controlled Blood Flow Abstract 37 Introduction 38...surrounding the body, e.g., atmospheric pressure , pressure al high and low altitudes, high underwater pressure , vacuum and excessive gravity acceleration...Resistance of the AreriolarNenous capillary, accounting for the pressure drop observed between them. RCB Resistance of the Blood -Brain barrier (between

Effects of Front-Loading and Stagger Angle on Endwall Losses of High Lift Low Pressure Turbine Vanes

DTIC Science & Technology

2012-09-01

TURBINE VANES DISSERTATION Presented to the Faculty Department of Aeronautical and Astronautical... Engineering and Management iv AFIT/DS/ENY/12-05 Abstract Past efforts to reduce the airfoil count in low pressure turbines have produced high lift...LOSSES OF HIGH LIFT LOW PRESSURE TURBINE VANES 1. Introduction The low pressure turbine (LPT) in modern high bypass ratio aero- engines is

Object Toolkit Version 4.3 User’s Manual

DTIC Science & Technology

2016-12-31

unlimited. (OPS-17-12855 dtd 19 Jan 2017) 13. SUPPLEMENTARY NOTES 14. ABSTRACT Object Toolkit is a finite - element model builder specifically designed for...INTRODUCTION 1 What Is Object Toolkit? Object Toolkit is a finite - element model builder specifically designed for creating representations of spacecraft...Nascap-2k and EPIC, the user is not required to purchase or learn expensive finite element generators to create system models. Second, Object Toolkit

Interaction of Lamb Waves with Fatigue Cracks in Aluminum

DTIC Science & Technology

2011-09-01

Interaction of Lamb Waves with Fatigue Cracks in Aluminum E. D. SWENSON, C. T. OWENS and C. ALLEN ABSTRACT Elastic waves can travel across...the interaction of Lamb waves with both open and closed low-cycle fatigue cracks in aluminum plates using a three-dimensional laser Doppler vibrometer...and antisymmetric Lamb wave modes differ upon encountering fatigue cracks. INTRODUCTION The use of guided elastic waves (Lamb waves) has shown

Stunden abstract. Der Einsatz von Nachrichten im Leistungskurs "Social Problems" (Class-Hour Plan. The Introduction of News in the Honors Course "Social Problems")

ERIC Educational Resources Information Center

Pegler, Klaus

1977-01-01

Gives a detailed ESL (English as a second language) class-hour plan for using a BBC radio news program on vandalism as a social problem. Teaching goals, teaching materials and methodology are discussed. The working texts are appended; the news tests are available free from the author. (Text is in German.) (IFS/WGA)

An Introduction to Groups. Abstract Algebra. Modules and Monographs in Undergraduate Mathematics and Its Applications Project. UMAP Unit 461.

ERIC Educational Resources Information Center

Rosenberg, Nancy S.

A group is viewed to be one of the simplest and most interesting algebraic structures. The theory of groups has been applied to many branches of mathematics as well as to crystallography, coding theory, quantum mechanics, and the physics of elementary particles. This material is designed to help the user: 1) understand what groups are and why they…

Establishment of Vespa bicolor in Taiwan (Hymenoptera: Vespidae)

PubMed Central

Sung, I-Hsin; Lu, Sheng-Shan; Chao, Jung-Tai; Yeh, Wen-Chi; Lee, Wei-Jie

2014-01-01

Abstract The establishment of a hornet, Vespa bicolor F., in Taiwan was confirmed based on successful field collection of adults of both sexes and two subterranean colonies. Information on nesting habitat, nest measurement, and colony composition of this species are provided in this article. V. bicolor is the ninth hornet species ever recorded from Taiwan. Possible pathway for the introduction of this alien species is also discussed. PMID:25434034

Analysis of Helical Waveguide.

DTIC Science & Technology

1985-12-23

tube Efficiency Helix structure Backward wave oscillation Gain 19. ABSTRACT (Continue on reverse if necessary and identofy by block number) The...4,vailabilitY CCdes -vai aidIorDist spec a ." iii "- -. .5- S.. . ANALYSIS OF HELICAL WAVEGUIDE I. INTRODUCTION High power (- 10 kW) and broadband ...sys- tems. The frequency range of interest is 60-100 GHz. In this frequency range, the conventional slow wave circuits such as klystrons and TWTs have

Pediatric Susceptibility to Nerve Agent-Induced Seizures and Effectiveness of Anticonvulsant Treatments

DTIC Science & Technology

2013-10-01

SUPPLEMENTARY NOTES 14. ABSTRACT Organophosphate (OP) poisoning can result in status epilepticus (SE), a medical emergency which can become...Introduction Organophosphate (OP) poisoning can result in status epilepticus (SE), a medical emergency which can become pharmacoresistant if...P28 rat pups. Figure 1. DFP-induced status epilepticus in a P28 rat. Animals were treated with 0.026 mg/kg pyridostigmine bromide (i.p.) 30 min

Modeling the Distribution of Fingerprint Characteristics. Revision 1.

DTIC Science & Technology

1980-09-19

the details of the print. The ridge-line details are termed Galton characteristics since Sir Francis Galton was among the first to study them...U.S.A. CONTENTS Abstract 1. Introduction 2. Background Information on Fingerprints 2.1. Types 2.2. Ridge counts 2.3. The Galton details 3. Data...The Multinomial Markov Model 7. The Poisson Markov Model 8. The Infinitely Divisible Model Acknowledgements References Appendices A The Galton

Development and Operation of the Astrophysics Data System

NASA Technical Reports Server (NTRS)

Murray, Stephen S.

1997-01-01

The Astrophysics Data System (ADS) provides access to astronomical bibliographic information, including references, abstracts, and full journal articles, as well as links to other on-line information sources like on-line electronic journals and on-line data. This section will first provide a brief history of the ADS, a general introduction of the current system, and a more detailed description of some of the parts of the ADS.

Molecular Characterization of Indolent Prostate Cancer

DTIC Science & Technology

2013-10-01

SUPPLEMENTARY NOTES 14. ABSTRACT Indolent prostate cancers that pose very low risk to aged men occur frequently and may be detected at biopsy, leading...Introduction Indolent prostate cancers that pose very low risk to aged men occur frequently and may be detected at biopsy, leading to the...cancer at the time of biopsy detection and thus meeting the entry criteria for active surveillance. The scope of the proposed research is: 1) to

Characterization of Mechanical Damage Mechanisms in Ceramic and Polymeric Matrix Composite Materials

DTIC Science & Technology

1991-11-01

microplasticity is a vital factor in the compressive failure of even these very hard materials under essentially all conditions (temperature, strain rate...OF CONTENTS Pag= The Compressive Strength of Strong Ceramics: Microplasticity Versus 1 Microfracture Abstract 1 1. Introduction 2 2. Hardness 3 3...Acknowledgements 51 References 51 COATVANOORD1 24-91CDXC 11. LIST OF FIGURES Figure Page The Compressive Strength of Strong Ceramics: Microplasticity Versus

Increasing Treatment Seeking Among at-Risk Service Members Returning from Warzones

DTIC Science & Technology

2016-03-01

SUPPLEMENTARY NOTES 14. ABSTRACT We propose a randomized controlled clinical trial of 1,200 military service members who are at increased risk for suicide but...n/a INTRODUCTION TO SPECIFIC AIMS Reducing suicide is a national priority and an urgent concern within the Department...of Defense and the Department of Veterans Affairs. The passage of the Joshua Omvig Veterans Suicide Prevention Act highlights the importance that

Two-Way Satellite Time and Frequency Transfer (TWSTFT) Calibration Constancy From Closure Sums

DTIC Science & Technology

2008-12-01

40th Annual Precise Time and Time Interval (PTTI) Meeting 587 TWO-WAY SATELLITE TIME AND FREQUENCY TRANSFER ( TWSTFT ) CALIBRATION...Paris, France Abstract Two-way Satellite Time and Frequency Transfer ( TWSTFT ) is considered to be the most accurate means of long-distance...explanations for small, but non-zero, biases observed in the closure sums of uncalibrated data are presented. I. INTRODUCTION TWSTFT [1] has

Spontaneous Speech Collection for the CSR Corpus

DTIC Science & Technology

1992-01-01

Menlo Park, California 94025 1. ABSTRACT As part of a pilot data collection for DARPA’s Continuous Speech Recognition ( CSR ) speech corpus, SRI...International experi- mented with the collection of spontaneous speeoh material. The bulk of the CSR pilot data was read versions of news articles from...variable. 2. INTRODUCTION The CSR (Continuous Speech Recognition) Corpus collec- tion can be considered the successor to the Resource Man- agemen t

Molecularly imprinted polymers for the detection of illegal drugs and additives: a review.

PubMed

Xiao, Deli; Jiang, Yue; Bi, Yanping

2018-04-04

This review (with 154 refs.) describes the current status of using molecularly imprinted polymers in the extraction and quantitation of illicit drugs and additives. The review starts with an introduction into some synthesis methods (lump MIPs, spherical MIPs, surface imprinting) of MIPs using illicit drugs and additives as templates. The next section covers applications, with subsections on the detection of illegal additives in food, of doping in sports, and of illicit addictive drugs. A particular focus is directed towards current limitations and challenges, on the optimization of methods for preparation of MIPs, their applicability to aqueous samples, the leakage of template molecules, and the identification of the best balance between adsorption capacity and selectivity factor. At last, the need for convincing characterization methods, the lack of uniform parameters for defining selectivity, and the merits and demerits of MIPs prepared using nanomaterials are addressed. Strategies are suggested to solve existing problems, and future developments are discussed with respect to a more widespread use in relevant fields. Graphical abstract This review gives a comprehensive overview of the advances made in molecularly imprinting of polymers for use in the extraction and quantitation of illicit drugs and additives. Methods for syntheses, highlighted applications, limitations and current challenges are specifically addressed.

Rethinking Thought Disorder

PubMed Central

Hart, Mara

2017-01-01

Abstract It has been 30 years since Holzman introduced a special issue of the Schizophrenia Bulletin entitled “Thought Disorder in Schizophrenia.” He pointed out in his Editor’s Introduction that in contrast to the explosion of interest at that time in the biological aspects of schizophrenia, there were important areas of study that represented “... relatively neglected aspects of the psychopathology of schizophrenia, namely the varieties of thinking disorders (emphasis added) characteristic of schizophrenic patients and their possible underlying mechanisms.” Perhaps presciently, he ended his introduction by expressing hope that the articles included in that issue would lead to further intensive study of the cognitive (emphasis added) dysfunctions in schizophrenia. There has, indeed, been extensive research conducted in further understanding cognitive dysfunctions in schizophrenia, but considerably less so in understanding thought disorder. PMID:28204762

Logical errors on proving theorem

NASA Astrophysics Data System (ADS)

Sari, C. K.; Waluyo, M.; Ainur, C. M.; Darmaningsih, E. N.

2018-01-01

In tertiary level, students of mathematics education department attend some abstract courses, such as Introduction to Real Analysis which needs an ability to prove mathematical statements almost all the time. In fact, many students have not mastered this ability appropriately. In their Introduction to Real Analysis tests, even though they completed their proof of theorems, they achieved an unsatisfactory score. They thought that they succeeded, but their proof was not valid. In this study, a qualitative research was conducted to describe logical errors that students made in proving the theorem of cluster point. The theorem was given to 54 students. Misconceptions on understanding the definitions seem to occur within cluster point, limit of function, and limit of sequences. The habit of using routine symbol might cause these misconceptions. Suggestions to deal with this condition are described as well.

Naming a Lego world. The role of language in the acquisition of abstract concepts.

PubMed

Granito, Carmen; Scorolli, Claudia; Borghi, Anna Maria

2015-01-01

While embodied approaches of cognition have proved to be successful in explaining concrete concepts and words, they have more difficulties in accounting for abstract concepts and words, and several proposals have been put forward. This work aims to test the Words As Tools proposal, according to which both abstract and concrete concepts are grounded in perception, action and emotional systems, but linguistic information is more important for abstract than for concrete concept representation, due to the different ways they are acquired: while for the acquisition of the latter linguistic information might play a role, for the acquisition of the former it is instead crucial. We investigated the acquisition of concrete and abstract concepts and words, and verified its impact on conceptual representation. In Experiment 1, participants explored and categorized novel concrete and abstract entities, and were taught a novel label for each category. Later they performed a categorical recognition task and an image-word matching task to verify a) whether and how the introduction of language changed the previously formed categories, b) whether language had a major weight for abstract than for concrete words representation, and c) whether this difference had consequences on bodily responses. The results confirm that, even though both concrete and abstract concepts are grounded, language facilitates the acquisition of the latter and plays a major role in their representation, resulting in faster responses with the mouth, typically associated with language production. Experiment 2 was a rating test aiming to verify whether the findings of Experiment 1 were simply due to heterogeneity, i.e. to the fact that the members of abstract categories were more heterogeneous than those of concrete categories. The results confirmed the effectiveness of our operationalization, showing that abstract concepts are more associated with the mouth and concrete ones with the hand, independently from heterogeneity.

Naming a Lego World. The Role of Language in the Acquisition of Abstract Concepts

PubMed Central

Granito, Carmen; Scorolli, Claudia; Borghi, Anna Maria

2015-01-01

While embodied approaches of cognition have proved to be successful in explaining concrete concepts and words, they have more difficulties in accounting for abstract concepts and words, and several proposals have been put forward. This work aims to test the Words As Tools proposal, according to which both abstract and concrete concepts are grounded in perception, action and emotional systems, but linguistic information is more important for abstract than for concrete concept representation, due to the different ways they are acquired: while for the acquisition of the latter linguistic information might play a role, for the acquisition of the former it is instead crucial. We investigated the acquisition of concrete and abstract concepts and words, and verified its impact on conceptual representation. In Experiment 1, participants explored and categorized novel concrete and abstract entities, and were taught a novel label for each category. Later they performed a categorical recognition task and an image-word matching task to verify a) whether and how the introduction of language changed the previously formed categories, b) whether language had a major weight for abstract than for concrete words representation, and c) whether this difference had consequences on bodily responses. The results confirm that, even though both concrete and abstract concepts are grounded, language facilitates the acquisition of the latter and plays a major role in their representation, resulting in faster responses with the mouth, typically associated with language production. Experiment 2 was a rating test aiming to verify whether the findings of Experiment 1 were simply due to heterogeneity, i.e. to the fact that the members of abstract categories were more heterogeneous than those of concrete categories. The results confirmed the effectiveness of our operationalization, showing that abstract concepts are more associated with the mouth and concrete ones with the hand, independently from heterogeneity. PMID:25629816

Trends in Rate of Seizure-Associated Hospitalizations Among Children <5 Years Old Before and After Rotavirus Vaccine Introduction in the United Sates, 2000-2013.

PubMed

Pringle, Kimberly D; Burke, Rachel M; Steiner, Claudia A; Parashar, Umesh D; Tate, Jacqueline E

2018-01-30

Rotavirus is a common cause of acute gastroenteritis and has also been associated with generalized tonic-clonic afebrile seizures. Since rotavirus vaccine introduction, hospitalizations for treatment of acute gastroenteritis have decreased. We assess whether there has been an associated decrease in seizure-associated hospitalizations. We used discharge codes to abstract data on seizure hospitalizations among children <5 years old from the State Inpatient Databases of the Healthcare Cost and Utilization Project. We compared seizure hospitalization rates before and after vaccine introduction, using Poisson regression, stratifying by age and by month and year of admission. We performed a time-series analysis with negative binomial models, constructed using prevaccine data from 2000 to 2006 and controlling for admission month and year. We examined 962899 seizure hospitalizations among children <5 years old during 2000-2013. Seizure rates after vaccine introduction were lower than those before vaccine introduction by 1%-8%, and rate ratios decreased over time. Time-series analyses demonstrated a decrease in the number of seizure-coded hospitalizations in 2012 and 2013, with notable decreases in children 12-17 months and 18-23 months. Our analysis provides evidence for a decrease in seizure hospitalizations following rotavirus vaccine introduction in the United States, with the greatest impact in age groups with a high rotavirus-associated disease burden and during rotavirus infection season. Published by Oxford University Press for the Infectious Diseases Society of America 2018. This work is written by (a) US Government employee(s) and is in the public domain in the US.

The China Patient-centered Evaluative Assessment of Cardiac Events (China PEACE) retrospective heart failure study design

PubMed Central

Yu, Yuan; Zhang, Hongzhao; Li, Xi; Lu, Yuan; Masoudi, Frederick A; Li, Jing

2018-01-01

Introduction Heart failure (HF) is a leading cause of hospitalisation in China, which is experiencing a rapid increase in cardiovascular disease prevalence. Yet, little is known about current burden of disease, quality of care and treatment outcomes of HF in China. The objective of this paper is to describe the study methodology, data collection and abstraction, and progress to date of the China Patient-centered Evaluative Assessment of Cardiac Events 5 Retrospective Heart Failure Study (China PEACE 5r-HF). Methods and analysis The China PEACE 5r-HF Study will examine a nationally representative sample of more than 10 000 patient records hospitalised for HF in 2015 in China. The study is a retrospective cohort study. Patients have been selected using a two-stage sampling design stratified by economic–geographical regions. We will collect patient characteristics, diagnostic testing, treatments and in-hospital outcomes, including death and complications, and charges of hospitalisation. Data quality will be monitored by a central coordinating centre and will address case ascertainment, data abstraction and data management. As of October 2017, we have sampled 15 538 medical records from 189 hospitals, and have received 15 057 (96.9%) of these for data collection, and completed data abstraction and quality control on 7971. Ethics and dissemination The Central Ethics Committee at the Chinese National Center for Cardiovascular Diseases approved the study. All collaborating hospitals accepted central ethics committee approval with the exception of 15 hospitals, which obtained local approval by internal ethics committees. Findings will be disseminated in future peer-reviewed papers and will serve as a foundation for improving the care for HF in China. Trial registration number NCT02877914. PMID:29748344

Hot Idea or Hot Air: A Systematic Review of Evidence for Two Widely Marketed Youth Suicide Prevention Programs and Recommendations for Implementation

PubMed Central

Wei, Yifeng; Kutcher, Stan; LeBlanc, John C.

2015-01-01

Introduction: Youth suicide is highly related to mental disorders. While communities and schools are marketed to with a plethora of suicide prevention programs, they often lack the capacity to choose evidence-based programs. Methods: We conducted a systematic review of two youth suicide prevention programs to help determine if the quality of evidence available justifies their wide spread dissemination. We searched Medline, PsycINFO, EMBASE, CINAHL, the Cochrane Library, Campbell Collaboration SPECTR database, SocIndex, Sociological Abstracts, Social Services Abstracts, ERIC, Social Work Abstracts, Research Library, and Web of Science, for relevant studies. We included studies/systematic reviews/meta-analysis that evaluated the effectiveness, cost-effectiveness, and/or safety of Signs of Suicide (SOS) and Yellow Ribbon (YR) suicide prevention programs that target adolescents. We applied the Office of Justice Program What Works Repository (OJP-R) to evaluate the quality of the included studies as effective, effective with reservation, promising, inconclusive evidence, insufficient evidence, and ineffective. Two SOS studies were ranked as “inconclusive evidence” based on the OJP-R. One SOS study was ranked as having “insufficient evidence” on OJP-R. The YR study was ranked as “ineffective” using OJP-R. We only included studies in peer-reviewed journals in English and therefore may have missed reports in grey literature or non-English publications. Results: We cannot recommend that schools and communities implement either the SOS or YR suicide prevention programs. Purchasers of these programs should be aware that there is no evidence that their use prevents suicide. Conclusions: Academics and organizations should not overstate the positive impacts of suicide prevention interventions when the evidence is lacking. PMID:26336375

Clinical Effectiveness of Aloe Vera in the Management of Oral Mucosal Diseases- A Systematic Review

PubMed Central

Nair, Gopakumar Ramachandran; Naidu, Giridhar Seetharam; Jain, Supreet; Makkad, Ramanpal Singh; Jha, Abhishek

2016-01-01

Introduction Aloe vera is well known for its medicinal properties which lead to its application in treating various diseases. Its use in treating oral lesions has not been much documented in literature. Aim Although, systematic reviews on aloe vera and its extracts have been done earlier, but in relation to oral diseases this is the first systematic review. The aim of the present systematic review was to compile evidence based studies on the effectiveness of Aloe vera in treatment of various oral diseases. Materials and Methods Computerized literature searches were performed to identify all published articles in the subject. The following databases were used: PUBMED [MEDLINE], SCOPUS, COCHRANE DATABASE, EMBASE and SCIENCE DIRECT using specific keywords. The search was limited to articles published in English or with an English Abstract. All articles (or abstracts if available as abstracts) were read in full. Data were extracted in a predefined fashion. Assessment was done using Jadad score. Results Fifteen studies satisfied the inclusion criteria. Population of sample study ranged from 20 patients to 110 patients with clinically diagnosed oral mucosal lesions. Out of 15 studies, five were on patients with oral lichen planus, two on patients with oral submucous fibrosis, other studies were carried on patients with burning mouth syndrome, radiation induced mucositis, candida associated denture stomatitis, xerostomic patients and four were on minor recurrent apthous stomatitis. Most studies showed statistically significant result demonstrating the effectiveness of Aloe vera in treatment of oral diseases. Conclusion Although there are promising results but in future, more controlled clinical trials are required to prove the effectiveness of Aloe vera for management of oral diseases. PMID:27656587

English-as-a-Second-Language Programs in Basic Skills Education Program 1

DTIC Science & Technology

1984-01-01

languages and English as a second language . These theories and findings have led, in turn, to the development of new methods for teaching languages ...INTRODUCTION TO TEACHING TECHNIQUES FOR ENGLISH AS A SECOND LANGUAGE . . . . . . . . . . . . 9 Introduction ............................. 9 Traditional Methods ...instruments. q8 . _. ,’,..8 4% .’ II. A BRIEF INTRODUCTION TO TEACHING TECHNIQUES FOR ENGLISH

Abstraction Techniques for Parameterized Verification

DTIC Science & Technology

2006-11-01

approach for applying model checking to unbounded systems is to extract finite state models from them using conservative abstraction techniques. Prop...36 2.5.1 Multiple Reference Processes . . . . . . . . . . . . . . . . . . . 36 2.5.2 Adding Monitor Processes...model checking to complex pieces of code like device drivers depends on the use of abstraction methods. An abstraction method extracts a small finite

Methods for solving reasoning problems in abstract argumentation – A survey

PubMed Central

Charwat, Günther; Dvořák, Wolfgang; Gaggl, Sarah A.; Wallner, Johannes P.; Woltran, Stefan

2015-01-01

Within the last decade, abstract argumentation has emerged as a central field in Artificial Intelligence. Besides providing a core formalism for many advanced argumentation systems, abstract argumentation has also served to capture several non-monotonic logics and other AI related principles. Although the idea of abstract argumentation is appealingly simple, several reasoning problems in this formalism exhibit high computational complexity. This calls for advanced techniques when it comes to implementation issues, a challenge which has been recently faced from different angles. In this survey, we give an overview on different methods for solving reasoning problems in abstract argumentation and compare their particular features. Moreover, we highlight available state-of-the-art systems for abstract argumentation, which put these methods to practice. PMID:25737590

Automating Disk Forensic Processing with SleuthKit, XML and Python

DTIC Science & Technology

2009-05-01

1 Automating Disk Forensic Processing with SleuthKit, XML and Python Simson L. Garfinkel Abstract We have developed a program called fiwalk which...files themselves. We show how it is relatively simple to create automated disk forensic applications using a Python module we have written that reads...software that the portable device may contain. Keywords: Computer Forensics; XML; Sleuth Kit; Python I. INTRODUCTION In recent years we have found many

GaN on Diamond with Ultra-Low Thermal Barrier Resistance

DTIC Science & Technology

2016-03-31

GaN-on-Diamond with Ultra-Low Thermal Barrier Resistance Xing Gu1, Cathy Lee1, Jinqiao Xie1, Edward Beam1, Michael Becker2, Timothy A. Grotjohn2...Bristol BS8 1TL, UK Abstract: We investigated the effective thermal boundary resistance (TBReff) of GaN-on-Diamond interfaces for diamond growth... thermal boundary resistance; TBReff , interfacial layers; high density dielectric Introduction While GaN-based RF transistors, typically on SiC

The Single Period Inventory Model: Origins, Solutions, Variations, and Applications.

DTIC Science & Technology

1977-09-01

IN OPERATIONS RESEARCH from the NAVAL POSTGRADUATE SCHOOL September 1977 Author Approved by: :c^L*S /y^td^US^C. f. :t.’.".S,. Chairman...Department of Operations Research Dean of Information/and Policy Sciences "•>.’• • . ABSTRACT The classic newspaper boy or single period inventory... Research , expended while assisting me in my thesis effort. I. INTRODUCTION This thesis is devoted to the origins and development of a single

Spice: A New Legal Herbal Mixture Abused by Young Active Duty Military Personnel

DTIC Science & Technology

2012-01-01

ABSTRACT. Spice is an herbal mixture smoked for euphoria and mixed with synthetic cannabinoids that are undetected on urine drug screens. Spice use has...more paranoia and hallucinations, and may differ for each brand. KEYWORDS. Cannabinoid, military, spice, substance abuse INTRODUCTION Use of synthetic ...regu- lations in an attempt to decrease the use of such synthetic psychoactive substances (1). There are few reports of Spice use and its potential

Center of Gravity in the Asymmetric Environment: Applicable or Not

DTIC Science & Technology

2006-06-01

public release; distribution unlimited 12b. DISTRIBUTION CODE 13. ABSTRACT (maximum 200 words) The military concept of a Center of Gravity ( COG ) in...changed a great deal since the introduction of COG . And in today’s asymmetric environment, in which non-state actors use unconventional tactics, it is...becoming extremely difficult to apply the COG concept. The primary reason for this difficulty is that non-state actors do not operate as a unitary

Swedish Defence Research Abstracts 80/81-2 (Froe Forsvars Forsknings Referat 80/81-2).

DTIC Science & Technology

1981-06-01

Introduction of critical path analysis in calculations of the effects on aerial targets E CONDUCT OF WAR - INFORMATION AND COMMAND TECHNIQUE (63) Optical...including signal interception and technical intelligence (72) The mechanism of a Baltic earthquake source obtained by analysis of recordings of surface...work - a concluding discussion H7 Testing and job analysis (91) Cardiopulmonary responses to arm exercise performed in various ways (in English) (92

The Millennial Generation in High Reliability Organizations (HRO)

DTIC Science & Technology

2014-02-13

protect, treat, and sustain the health of our service members. iv Abstract The Millennials (also known as Generation Y ) were born between...Introduction The Millennials (also known as Generation Y ) were born in the U.S. between 1981 and 1997, and comprise 30% of the U.S. population and 80...Soviet relations regardless of their religion or ethnic background is similar to other Baby boomers than it would be to a Millennial . The Baby boomers

ISO-LWS Spectroscopy of Centaurus A: Extended Star Formation

DTIC Science & Technology

2000-01-01

Astron. Astrophys. 355, 885–890 (2000) ASTRONOMY AND ASTROPHYSICS ISO-LWS spectroscopy of Centaurus A: extended star formation S.J. Unger1, P.E...University of Maryland, College Park, MD, USA Received 31 August 1999 / Accepted 18 January 2000 Abstract. We present the first full FIR spectrum of Centaurus ...individual: Centaurus A = NGC 5128 – infrared: galaxies – galaxies: ISM – galaxies: starburst – galax- ies: active 1. Introduction Centaurus A (NGC 5128

Local Inhibition of HSP90 to Prevent Intimal Hyperplasia after Balloon Injury

DTIC Science & Technology

2017-10-01

Unlimited 13. SUPPLEMENTARY NOTES 14. ABSTRACT Peripheral arterial disease (PAD) remains a major threat to life and limb and represents a disabling and...Organizations…………… 5 1 1. INTRODUCTION: Peripheral arterial disease (PAD) is a significant health problem that affects the aging military and veteran...population, ranging from lifestyle limiting claudication to major amputation and death. Further, there is growing rate of disorders in Cardiovascular Health

Creation of a United States Emergency Medical Services Administration Within the Department of Homeland Security

DTIC Science & Technology

2012-03-01

Little Philip and Ting-Ting, all my love. Thank you and God Bless ! 1 I. INTRODUCTION Emergency medical services personnel are critical resources ...equipment in times of duress. Resources must be available to distribute and utilize in times of need. FICEMS and the Office of Emergency Medical...DISTRIBUTION / AVAILABILITY STATEMENT Approved for public release; distribution is unlimited 12b. DISTRIBUTION CODE A 13. ABSTRACT (maximum 200 words

Three-Dimensional Sensor Common Operating Picture (3-D Sensor COP)

DTIC Science & Technology

2017-01-01

created. Additionally, a 3-D model of the sensor itself can be created. Using these 3-D models, along with emerging virtual and augmented reality tools...augmented reality 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT UU 18. NUMBER OF PAGES 20 19a...iii Contents List of Figures iv 1. Introduction 1 2. The 3-D Sensor COP 2 3. Virtual Sensor Placement 7 4. Conclusions 10 5. References 11

Optimization of a Solid-State Electron Spin Qubit Using Gate Set Tomography (Open Access, Publisher’s Version)

DTIC Science & Technology

2016-10-13

enielse@sandia.gov and a.morello@unsw.edu.au Keywords: quantum computing , silicon, tomography Supplementarymaterial for this article is available online...Abstract State of the art qubit systems are reaching the gatefidelities required for scalable quantum computation architectures. Further improvements in...and addressedwhen the qubit is usedwithin a fault-tolerant quantum computation scheme. 1. Introduction One of themain challenges in the physical

An introduction to using the FORTRAN programs provided with Computational Nuclear Physics 1 Nuclear Structure

NASA Technical Reports Server (NTRS)

Boytos, Matthew A.; Norbury, John W.

1992-01-01

The authors of this paper have provided a set of ready-to-run FORTRAN programs that should be useful in the field of theoretical nuclear physics. The purpose of this document is to provide a simple synopsis of the programs and their use. A separate section is devoted to each program set and includes: abstract; files; compiling, linking, and running; obtaining results; and a tutorial.

Taming a Tiger in the City: Comparison of Motorized Backpack Applications and Source Reduction Against the Asian Tiger Mosquito, Aedes albopictus

DTIC Science & Technology

2014-06-01

TAMING A TIGER IN THE CITY: COMPARISON OF MOTORIZED BACKPACK APPLICATIONS AND SOURCE REDUCTION AGAINST THE ASIAN TIGER MOSQUITO, AEDES ALBOPICTUS...FONSECA2 AND ARY FARAJOLLAHI2,3,7 ABSTRACT. We evaluated 2 strategies to manage Aedes albopictus: 1) motorized backpack applications and 2) source...the community level. KEY WORDS Bacillus thuringiensis israelensis, Bti, methoprene, hand applications, backpack applications INTRODUCTION Aedes

USSR and Eastern Europe Scientific Abstracts, Cybernetics, Computers, and Automation Technology, Number 26

DTIC Science & Technology

1977-01-26

Sisteme Matematicheskogo Obespecheniya YeS EVM [ Applied Programs in the Software System for the Unified System of Computers], by A. Ye. Fateyev, A. I...computerized systems are most effective in large production complexes , in which the level of utilization of computers can be as high as 500,000...performance of these tasks could be furthered by the complex introduction of electronic computers in automated control systems. The creation of ASU

Measurement of Venous Blood Flow in the Lower Limbs: Prevention of Deep Vein Thrombosis during Prolonged Sitting

DTIC Science & Technology

2004-06-01

Abstract. The venous blood flow during stretching and deep breathing in the sitting posture was examined in the present study. First, an...increase in the venous return. Therefore, we suggest that stretching and deep breathing can be used sometimes as preventive measures for deep vein...thrombosis during prolonged sitting. Keywords. Venous blood flow, Near infrared spectroscopy, Deep vein thrombosis. 1. Introduction It has been

Application of Two-Sided Matching to Internal Labor of the Hellenic Navy

DTIC Science & Technology

2012-03-01

were developed, leading to the introduction of various choice programs that allow parents to pick schools for their children within or outside...any nature (i.e., military) plays a crucial role towards the direction of efficiency and effectiveness. A well-designed assignment process is a handy...v ABSTRACT The assignment process in an organization of any nature (i.e., military) plays a crucial role towards the direction of efficiency and

Therapeutic Targeting of Lipid Droplets as Disease Markers in Ovarian Cancer

DTIC Science & Technology

2016-03-01

COVERED (From - To) 4. TITLE AND SUBTITLE 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 5d. PROJECT NUMBER 5e. TASK NUMBER 5f...CONTENTS Page # INTRODUCTION 2 KEYWORDS 2 PROJECT SUMMARY 2-9 KEY RESEARCH ACCOMPLISHMENTS 10 CONCLUSION AND FUTIRE PLANS 10 PUBLICATION/ABSTRACTS...Time to Recurrence, PFS- Progression Free Survival, OS-Overall Survival 3. OVERALL PROJECT SUMMARY: Milestone 1: Animal Use Approval-Prepare IACUC

A Novel Field-Deployable Point-of-Care Diagnostic Test for Cutaneous Leishmaniasis

DTIC Science & Technology

2016-10-01

14. ABSTRACT Leishmaniasis is caused by the protozoan Leishmania and is generally transmitted by the bite of sand flies of the genus Lutzomyia or...INTRODUCTION: Leishmaniasis is caused by the protozoan Leishmania and is generally transmitted by the bite of sand flies of the genus Lutzomyia or...and requires minimal training, will improve the quality of life of populations living in endemic areas. The availability of RPA-LF in economically

Pavlovian Fear Conditioning Activates a Common Pattern of Neurons in the Lateral Amygdala of Individual Brains

DTIC Science & Technology

2011-01-12

Abstract Understanding the physical encoding of a memory (the engram ) is a fundamental question in neuroscience. Although it has been established...assembly constitutes a spatial dimension of the engram . Citation: Bergstrom HC, McDonald CG, Johnson LR (2011) Pavlovian Fear Conditioning Activates a Common...competing interests exist. * E-mail: LukeJohnsonPhD@gmail.com Introduction Understanding the physical encoding of a memory (the engram ) in neuronal

Malignant melanoma (non-metastatic): sentinel lymph node biopsy

PubMed Central

2016-01-01

Introduction The incidence of malignant melanoma has increased over the past 25 years in the UK, but death rates have remained fairly constant. The 5-year survival rate ranges from 20% to 95%, depending on disease stage. Risks are greater in white populations and in people with higher numbers of skin naevi. Methods and outcomes We conducted a systematic overview, aiming to answer the following clinical question: What is the evidence for performing a sentinel lymph node biopsy in people with malignant melanoma with clinically uninvolved lymph nodes? We searched: Medline, Embase, The Cochrane Library and other important databases up to October 2014 (BMJ Clinical Evidence overviews are updated periodically; please check our website for the most up-to-date version of this overview). Results At this update, searching of electronic databases retrieved 221 studies. After deduplication and removal of conference abstracts, 99 records were screened for inclusion in the overview. Appraisal of titles and abstracts led to the exclusion of 58 studies and the further review of 41 full publications. Of the 41 full articles evaluated, one systematic review and three RCTs were added at this update. We performed a GRADE evaluation for two PICO combinations. Conclusions In this systematic overview, we evaluated the evidence for performing sentinel lymph node biopsy in people with malignant melanoma with clinically uninvolved lymph nodes. PMID:26788739

Late introduction of fish and eggs is associated with increased risk of allergy development – results from the FARMFLORA birth cohort

PubMed Central

Jonsson, K.; Barman, M.; Brekke, H. K.; Hesselmar, B.; Johansen, S.; Sandberg, A.-S.; Wold, A. E.

2017-01-01

ABSTRACT The prevalence of allergy is markedly low in children growing up on farms. An increasing number of studies indicate that the timing of food introduction may affect allergy development. We aimed to investigate if protection against allergy in farm environments may be mediated through differences in food-introduction practices between farm and non-farm families, using an explorative approach. Twenty-eight farm and 37 non-farm children were included in the FARMFLORA birth cohort. Practices of breastfeeding and introduction of formulas and complementary foods were collected by questionnaires at 6, 12, and 18 months of age. Allergy was diagnosed by pediatricians at 3 years of age. The only difference in food-introduction practices observed between farm and non-farm children was an earlier introduction of nuts in farmers (median month: 11 [IQR: 8–6] in farmers, 15 [12–19] in non-farmers). One farm child (4%) and 10 non-farm children (27%) were allergic at 3 years of age. Lower risk of allergy development was associated with early exclusive breastfeeding (continuous variable; OR = 0.59, 95% CI: 0.39–0.89), but also having received eggs (OR = 0.08, 95% CI: 0.13–0.54) and fish (logistic regression not applicable, P = 0.01 in likelihood ratio testing [χ2]) at 10 months of age or earlier compared to later. Our results were not affected by reverse causation, as judged by a questionnaire sent to the families in retrospect. Timing of introduction of complementary foods is unlikely to contribute to the lower risk of allergy among farm children. Although early exclusive breastfeeding was associated with a lower rate of allergy development, postponed introduction of complementary foods might increase the risk of developing allergy. Owing to the limited sample size, our results are only indicative, but support prior findings. PMID:29151834

Moving beyond regression techniques in cardiovascular risk prediction: applying machine learning to address analytic challenges.

PubMed

Goldstein, Benjamin A; Navar, Ann Marie; Carter, Rickey E

2017-06-14

Risk prediction plays an important role in clinical cardiology research. Traditionally, most risk models have been based on regression models. While useful and robust, these statistical methods are limited to using a small number of predictors which operate in the same way on everyone, and uniformly throughout their range. The purpose of this review is to illustrate the use of machine-learning methods for development of risk prediction models. Typically presented as black box approaches, most machine-learning methods are aimed at solving particular challenges that arise in data analysis that are not well addressed by typical regression approaches. To illustrate these challenges, as well as how different methods can address them, we consider trying to predicting mortality after diagnosis of acute myocardial infarction. We use data derived from our institution's electronic health record and abstract data on 13 regularly measured laboratory markers. We walk through different challenges that arise in modelling these data and then introduce different machine-learning approaches. Finally, we discuss general issues in the application of machine-learning methods including tuning parameters, loss functions, variable importance, and missing data. Overall, this review serves as an introduction for those working on risk modelling to approach the diffuse field of machine learning. © The Author 2016. Published by Oxford University Press on behalf of the European Society of Cardiology.

Extragalactic Fields Optimized for Adaptive Optics

DTIC Science & Technology

2011-03-01

DAVID MONETIO Received 2010 luly 19; accepted 2010 December 30; published 2011 March 1 ABSTRACT. In this article we present the coordinates of 67 55’ x...Window, contains most of the patches we have identified. Our optimal field, centered at R.A.: 7h24m3s, decl.: - 1 °27󈧓", has an additional advantage of...equivalent observations undertaken in existing deep fields. Online material: color figures 1 . INTRODUCTION Our understanding of the high-redshift

Department of Defense Atlas/Data Abstract for the United States and Selected Areas. Fiscal Year 1992

DTIC Science & Technology

1993-01-01

PUBLICATION IS DIOR/L-03-92, TABLE OF CONTENTS Page INTRODUCTION ........................................................... 2 MAPS AND STATISTICAL...Mexico (NH) 32 80 New York (NY) 33 82 North Carolina (NC) 34 84 North Dakota (ND) 35 86 Ohio (OH) 36 88 TABLE OF CONTENTS (Continued) State/Area Map...ZIMMERMIANN BASIL CORP JV 34,679 Operation/Ammunition Facilities 34,679 3. MORRISON KNUDSEN CORP 30,923 Facilities Operations Support Services 30,923 4

Flexural Fatigue Response of Repaired S2-Glass/Vinyl Ester Composites

DTIC Science & Technology

2009-08-01

of Mechanical Engineering & Applied Mechanics, North Dakota State University, Fargo, ND 58105 14. ABSTRACT Vacuum-assisted resin transfer molding ...Introduction 1  2.  Vacuum-Assisted Resin Transfer Molding 2  3.  Repair Strategies 2  4.  Processing and Repairing Laminates 4  5.  Experimental 4  5.1  Set 1...vacuum-assisted resin transfer molding (VARTM) (2), performance evaluations have assumed increasing importance due to the lack of historical databases on

A Versatile Glass Processor for High-Performance Photonic Platforms

DTIC Science & Technology

2015-12-08

St . Louis, MO 63130 -4862 ABSTRACT Number of Papers published in peer...Skinner Professor, Electrical and Systems Engineering Department, Washington University, St . Louis, MO 63130 1. Introduction With...al iz ed re so na nc e w av el en gt h sh ift (W G M re so na nc e) a nd no rm al iz ed e la st ic m od ul us c ha ng e (rh eo lo gy ) 0

Development of Convergence Nanoparticles (Phase II): Detection and Therapeutics of Pathogen Targets by Using Multi-Mode Hybrid Nanoparticle Probe

DTIC Science & Technology

2010-04-05

Chloride (Aldrich 45011, 5g) 1 -Ethyl- 3 -[ 3 - dimethylaminopropyl ]carbodiimide hydrochloride (Pierce 25952-53-8, 25g) Oleylamine (Aldrich O7805, 500g...email: jcheon@yonsei.ac.kr Table of Content 1 . Abstract 2. Introduction 3 . Approach 4. Results and discussions 5. Pay-off 6. Summary 7...highly accurate detection and therapeutics of biological pathogens. 3 . Approaches 1 ) Approach Our research was focused on the development of

As Simple as Possible, But No Simpler: A Gentle Introduction to Simulation Modeling

DTIC Science & Technology

2006-12-01

cultures, people waiting for a bus mimic the concept by standing in a row. However, there are some cultures where no line forms but it is considered...mathematical equations such as the equations of motion Report Documentation Page Form ApprovedOMB No. 0704-0188 Public reporting burden for the...PERSON a. REPORT unclassified b. ABSTRACT unclassified c. THIS PAGE unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18

Secret Lanthanides

PubMed Central

Sturza, CM

2014-01-01

Abstract Lanthanides are a group of 15 chemical elements which, together with their salts, have come to be used in the last decade as homoeopathic remedies. The effective introduction of lanthanides and their salts into the clinical use, as homoeopathic remedies was based on the idea of Jan Scholten, MD to relate their physicochemical properties shown in the periodic table of elements to their homoeopathic potential. The lanthanides and their salts were prepared as homoeopathic remedies by Pharmacist Robert Münz. PMID:25408760

Research in Outdoor Education, Volume 6. A Peer-Reviewed Publication of Scholarship First Presented at the Biennial Research Symposium of the Coalition for Education in the Outdoors (6th, Bradford Woods, Indiana, January 11-13, 2002).

ERIC Educational Resources Information Center

Bialeschki, M. Deborah, Ed.; Henderson, Karla A., Ed.; Young, Anderson B., Ed.; Andrejewski, Robert G., Ed.

This volume contains peer-reviewed research articles and abstracts based on papers presented at the sixth biennial research symposium of the Coalition for Education in the Outdoors. Introductory materials include the editors' introduction, "Milestones in Outdoor Education" (Anderson B. Young), and a tribute to the founder of the Indiana University…

Four Frames Suffice. A Provisionary Model of Vision and Space,

DTIC Science & Technology

1982-09-01

0 * / Justifi ati AvailabilitY Codes 1. Introduction This paper is an attempt to specify’ a computationally and scientifically plausible model of how...abstract neural compuiting unit and a variety of construtions built of these units and their properties. All of this is part of the connectionist...chosen are inlerided to elucidate the nia’or scientific problems in intermediate level vision and would not be the best choice or a practical computer

Clarifying the abstracts of systematic literature reviews*

PubMed Central

Hartley, James

2000-01-01

Background: There is a small body of research on improving the clarity of abstracts in general that is relevant to improving the clarity of abstracts of systematic reviews. Objectives: To summarize this earlier research and indicate its implications for writing the abstracts of systematic reviews. Method: Literature review with commentary on three main features affecting the clarity of abstracts: their language, structure, and typographical presentation. Conclusions: The abstracts of systematic reviews should be easier to read than the abstracts of medical research articles, as they are targeted at a wider audience. The aims, methods, results, and conclusions of systematic reviews need to be presented in a consistent way to help search and retrieval. The typographic detailing of the abstracts (type-sizes, spacing, and weights) should be planned to help, rather than confuse, the reader. PMID:11055300

Odors and Air Pollution: A Bibliography with Abstracts.

ERIC Educational Resources Information Center

Environmental Protection Agency, Research Triangle Park, NC. Office of Air Programs.

The annotated bibliography presents a compilation of abstracts which deal with odors as they relate to air pollution. The abstracts are arranged within the following categories: Emission sources; Control methods; Measurement methods; Air quality measurements; Atmospheric interaction; Basic science and technology; Effects-human health;…

Introduction to Geostatistics

NASA Astrophysics Data System (ADS)

Kitanidis, P. K.

1997-05-01

Introduction to Geostatistics presents practical techniques for engineers and earth scientists who routinely encounter interpolation and estimation problems when analyzing data from field observations. Requiring no background in statistics, and with a unique approach that synthesizes classic and geostatistical methods, this book offers linear estimation methods for practitioners and advanced students. Well illustrated with exercises and worked examples, Introduction to Geostatistics is designed for graduate-level courses in earth sciences and environmental engineering.

The (lack of) effect of dynamic visual noise on the concreteness effect in short-term memory.

PubMed

Castellà, Judit; Campoy, Guillermo

2018-05-17

It has been suggested that the concreteness effect in short-term memory (STM) is a consequence of concrete words having more distinctive and richer semantic representations. The generation and storage of visual codes in STM could also play a crucial role on the effect because concrete words are more imaginable than abstract words. If this were the case, the introduction of a visual interference task would be expected to disrupt recall of concrete words. A Dynamic Visual Noise (DVN) display, which has been proven to eliminate the concreteness effect on long-term memory (LTM), was presented along encoding of concrete and abstract words in a STM serial recall task. Results showed a main effect of word type, with more item errors in abstract words, a main effect of DVN, which impaired global performance due to more order errors, but no interaction, suggesting that DVN did not have any impact on the concreteness effect. These findings are discussed in terms of LTM participation through redintegration processes and in terms of the language-based models of verbal STM.

Three countries' experience with Norplant introduction.

PubMed

Hardee, K; Balogh, S; Villinski, M T

1997-09-01

Despite international efforts to plan for Norplant introduction, the method has drawn the attention of critics of family planning programmes, and has raised several issues for debate since it was introduced into family planning programmes. The experiences of three countries with the introduction of Norplant highlight some of the unique features of the method that have affected its introduction. Indonesia, Bangladesh and the United States represent diverse cultural settings and systems of family planning provision. Experience in each country has highlighted the need to focus on quality of care for clients, most notably the need for good counselling and attention to removal as well as insertion. The cost of Norplant also has influenced its introduction in each country. Another issue includes the need to work with women's health advocacy groups, which is illustrated particularly in Bangladesh. Finally, the role of litigation in the United States, and its potential role in influencing Norplant introduction in other countries, is discussed. These three countries' experience illustrate the importance of understanding the programmatic context of contraceptive introduction.

Space safety and rescue 1979-1981: Worldwide disaster response, rescue and safety employing space-borne systems

NASA Technical Reports Server (NTRS)

Brown, J. W. (Editor)

1983-01-01

Selected papers from the 1979, 1980, and 1981 IAA symposia on space safety and rescue and on worldwide disaster response, safety, and rescue employing spaceborne systems are presented. Available papers published elsewhere and those presented at the 1976, 1977, and 1978 symposia are presented in abstract form. Subjects discussed include man-made space debris, nuclear-waste disposal in space, space-station safety design, psychological training, the introduction of female crewmembers, analysis of the November 23, 1980 earthquake as a design basis for satellite emergency communication, disaster warning using the GOES satellite, and satellite communications for disaster relief operations. Three reviews of the application of space technology to emergency and disaster relief and prevention, given at other symposia in 1981, are presented in an appendix. No individual items are abstracted in this volume

The method of abstraction in the design of databases and the interoperability

NASA Astrophysics Data System (ADS)

Yakovlev, Nikolay

2018-03-01

When designing the database structure oriented to the contents of indicators presented in the documents and communications subject area. First, the method of abstraction is applied by expansion of the indices of new, artificially constructed abstract concepts. The use of abstract concepts allows to avoid registration of relations many-to-many. For this reason, when built using abstract concepts, demonstrate greater stability in the processes. The example abstract concepts to address structure - a unique house number. Second, the method of abstraction can be used in the transformation of concepts by omitting some attributes that are unnecessary for solving certain classes of problems. Data processing associated with the amended concepts is more simple without losing the possibility of solving the considered classes of problems. For example, the concept "street" loses the binding to the land. The content of the modified concept of "street" are only the relations of the houses to the declared name. For most accounting tasks and ensure communication is enough.

A practical introduction to tensor networks: Matrix product states and projected entangled pair states

DOE Office of Scientific and Technical Information (OSTI.GOV)

Orús, Román, E-mail: roman.orus@uni-mainz.de

This is a partly non-technical introduction to selected topics on tensor network methods, based on several lectures and introductory seminars given on the subject. It should be a good place for newcomers to get familiarized with some of the key ideas in the field, specially regarding the numerics. After a very general introduction we motivate the concept of tensor network and provide several examples. We then move on to explain some basics about Matrix Product States (MPS) and Projected Entangled Pair States (PEPS). Selected details on some of the associated numerical methods for 1d and 2d quantum lattice systems aremore » also discussed. - Highlights: • A practical introduction to selected aspects of tensor network methods is presented. • We provide analytical examples of MPS and 2d PEPS. • We provide basic aspects on several numerical methods for MPS and 2d PEPS. • We discuss a number of applications of tensor network methods from a broad perspective.« less

Strategies for carbohydrate model building, refinement and validation

PubMed Central

2017-01-01

Sugars are the most stereochemically intricate family of biomolecules and present substantial challenges to anyone trying to understand their nomenclature, reactions or branched structures. Current crystallographic programs provide an abstraction layer allowing inexpert structural biologists to build complete protein or nucleic acid model components automatically either from scratch or with little manual intervention. This is, however, still not generally true for sugars. The need for carbohydrate-specific building and validation tools has been highlighted a number of times in the past, concomitantly with the introduction of a new generation of experimental methods that have been ramping up the production of protein–sugar complexes and glycoproteins for the past decade. While some incipient advances have been made to address these demands, correctly modelling and refining carbohydrates remains a challenge. This article will address many of the typical difficulties that a structural biologist may face when dealing with carbohydrates, with an emphasis on problem solving in the resolution range where X-ray crystallography and cryo-electron microscopy are expected to overlap in the next decade. PMID:28177313

Understanding the basis of space closure in Orthodontics for a more efficient orthodontic treatment

PubMed Central

Ribeiro, Gerson Luiz Ulema; Jacob, Helder B.

2016-01-01

ABSTRACT Introduction: Space closure is one of the most challenging processes in Orthodontics and requires a solid comprehension of biomechanics in order to avoid undesirable side effects. Understanding the biomechanical basis of space closure better enables clinicians to determine anchorage and treatment options. In spite of the variety of appliance designs, space closure can be performed by means of friction or frictionless mechanics, and each technique has its advantages and disadvantages. Friction mechanics or sliding mechanics is attractive because of its simplicity; the space site is closed by means of elastics or coil springs to provide force, and the brackets slide on the orthodontic archwire. On the other hand, frictionless mechanics uses loop bends to generate force to close the space site, allowing differential moments in the active and reactive units, leading to a less or more anchorage control, depending on the situation. Objective: This article will discuss various theoretical aspects and methods of space closure based on biomechanical concepts. PMID:27275623

PATHOPHYSIOLOGY, DIAGNOSIS AND TREATMENTOF DUMPING SYNDROME AND ITS RELATION TO BARIATRIC SURGERY

PubMed Central

CHAVES, Yasmin da Silva; DESTEFANI, Afrânio Côgo

2016-01-01

ABSTRACT Introduction The dumping syndrome is frequent in bariatric surgery. It is probably the most common syndrome following partial or complete gastrectomy. Its prevalence in partial gastrectomy can reach up to 50%, thus it can be a significant complication arising from some types of bariatric surgeries. Objective: Critical analysis on dumping syndrome, its pathophysiology, diagnosis and treatment. Methods: A literature review was performed using the key words: 'dumping syndrome', 'bariatric surgery' and 'rapid dumping syndrome'. Inclusion criteria were: books, original works, case reports and meta-analyzes, and the exclusion criterion was literature review. Concerning the publication time, articles were screened between 1960 and May 2015. Results: The dumping syndrome is complication arising from obesity surgeries, but also can be a result of vagus nerve damage. Diagnosis is done primarily through the use of questionnaires based on scores. Conclusion: The Sigstad score and Arts survey are valid means for assessing the dumping syndrome. Initial therapy consists in the adoption of dietary measures, short acting drugs administration. PMID:27683791

High-intensity laser application in Orthodontics

PubMed Central

Sant’Anna, Eduardo Franzotti; Araújo, Mônica Tirre de Souza; Nojima, Lincoln Issamu; da Cunha, Amanda Carneiro; da Silveira, Bruno Lopes; Marquezan, Mariana

2017-01-01

ABSTRACT Introduction: In dental practice, low-level laser therapy (LLLT) and high-intensity laser therapy (HILT) are mainly used for dental surgery and biostimulation therapy. Within the Orthodontic specialty, while LLLT has been widely used to treat pain associated with orthodontic movement, accelerate bone regeneration after rapid maxillary expansion, and enhance orthodontic tooth movement, HILT, in turn, has been seen as an alternative for addressing soft tissue complications associated to orthodontic treatment. Objective: The aim of this study is to discuss HILT applications in orthodontic treatment. Methods: This study describes the use of HILT in surgical treatments such as gingivectomy, ulotomy, ulectomy, fiberotomy, labial and lingual frenectomies, as well as hard tissue and other dental restorative materials applications. Conclusion: Despite the many applications for lasers in Orthodontics, they are still underused by Brazilian practitioners. However, it is quite likely that this demand will increase over the next years - following the trend in the USA, where laser therapies are more widely used. PMID:29364385

Sex therapy for female sexual dysfunction

PubMed Central

2013-01-01

Introduction About 45% of women suffer from some form of sexual dysfunction. Despite its high prevalence, there are few studies that have systematically evaluated sex therapy in comparison with other interventions. Objective Review randomized clinical trials that present psychotherapeutic interventions for female sexual dysfunctions. Method Through a search in three databases (Medline, Web of Science and PsycInfo), 1419 references were found. After an analysis of the abstracts, twenty-seven articles met the inclusion criteria and composed this review. Results Sex therapy, as proposed by Masters and Johnson and Heiman and LoPiccolo, is still the most commonly used form of therapy for sexual dysfunctions; although it has shown results, the results do not consistently support that this is the best alternative in the treatment of sexual dysfunctions. Conclusion There is a lack of systematic study of many female sexual dysfunctions. Orgasmic disorder and sexual pain (vaginismus and dyspaurenia) are the most extensively studied disorders and those in which sex therapy seems to have better outcomes. PMID:24066697

Bone health in cerebral palsy and introduction of a novel therapy

PubMed Central

Scheinberg, Morton Aaron; Golmia, Ricardo Prado; Sallum, Adriana Maluf Elias; Pippa, Maria Guadalupe Barbosa; Cortada, Aline Pinheiros dos Santos; da Silva, Telma Gomes

2015-01-01

ABSTRACT Objective To assess the bone health status of children with cerebral palsy and the therapeutic effect of denosumab in a subgroup of children with cerebral palsy and decreased bone mass. Methods Children with cerebral palsy were evaluated according to their motor disability score (classification system gross motor functions III to V), bone density and bone turnover markers. Dual X-ray energy absorption was used to measure the lumbar spine, and total body, except the head. Thereafter a group of children with cerebral palsy and osteoporosis was treated with denosumab, a fully human monoclonal antibody. Bone turnover markers were measured before and three months after treatment. Results Reduction in bone mineral density was observed, particularly in children with greater impairment evaluated by the motor score. Decreased bone turnover markers were found in a selected group of children three months after exposure to denosumab. Conclusion Bone loss was present in children with significant impairment of motor function, as well as decreased serum levels of bone resorption markers with new forms. PMID:26761553

Highly Oriented Growth of Catalytically Active Zeolite ZSM‐5 Films with a Broad Range of Si/Al Ratios

PubMed Central

Fu, Donglong; Schmidt, Joel E.; Ristanović, Zoran; Chowdhury, Abhishek Dutta; Meirer, Florian

2017-01-01

Abstract Highly b‐oriented zeolite ZSM‐5 films are critical for applications in catalysis and separations and may serve as models to study diffusion and catalytic properties in single zeolite channels. However, the introduction of catalytically active Al3+ usually disrupts the orientation of zeolite films. Herein, using structure‐directing agents with hydroxy groups, we demonstrate a new method to prepare highly b‐oriented zeolite ZSM‐5 films with a broad range of Si/Al ratios (Si/Al=45 to ∞). Fluorescence micro‐(spectro)scopy was used to monitor misoriented microstructures, which are invisible to X‐ray diffraction, and show Al3+ framework incorporation and illustrate the differences between misoriented and b‐oriented films. The methanol‐to‐hydrocarbons process was studied by operando UV/Vis diffuse reflectance micro‐spectroscopy with on‐line mass spectrometry, showing that the b‐oriented zeolite ZSM‐5 films are active and stable under realistic process conditions. PMID:28675590

Mobile Videoconferencing Apps for Telemedicine

PubMed Central

Liu, Wei-Li; Locatis, Craig; Ackerman, Michael

2016-01-01

Abstract Introduction: The quality and performance of several videoconferencing applications (apps) tested on iOS (Apple, Cupertino, CA) and Android™ (Google, Mountain View, CA) mobile platforms using Wi-Fi (802.11), third-generation (3G), and fourth-generation (4G) cellular networks are described. Materials and Methods: The tests were done to determine how well apps perform compared with videoconferencing software installed on computers or with more traditional videoconferencing using dedicated hardware. The rationale for app assessment and the testing methodology are described. Results: Findings are discussed in relation to operating system platform (iOS or Android) for which the apps were designed and the type of network (Wi-Fi, 3G, or 4G) used. The platform, network, and apps interact, and it is impossible to discuss videoconferencing experienced on mobile devices in relation to one of these factors without referencing the others. Conclusions: Apps for mobile devices can vary significantly from other videoconferencing software or hardware. App performance increased over the testing period due to improvements in network infrastructure and how apps manage bandwidth. PMID:26204322

Reconsidering the International Association for the Study of Pain definition of pain

PubMed Central

Cohen, Milton; Quintner, John; van Rysewyk, Simon

2018-01-01

Abstract Introduction: The definition of pain promulgated by the International Association for the Study of Pain (IASP) is widely accepted as a pragmatic characterisation of that human experience. Although the Notes that accompany it characterise pain as “always subjective,” the IASP definition itself fails to sufficiently integrate phenomenological aspects of pain. Methods: This essay reviews the historical development of the IASP definition, and the commentaries and suggested modifications to it over almost 40 years. Common factors of pain experience identified in phenomenological studies are described, together with theoretical insights from philosophy and biology. Results: A fuller understanding of the pain experience and of the clinical care of those experiencing pain is achievable through greater attention to the phenomenology of pain, the social “intersubjective space” in which pain occurs, and the limitations of language. Conclusion: Based on these results, a revised definition of pain is offered: Pain is a mutually recognizable somatic experience that reflects a person's apprehension of threat to their bodily or existential integrity. PMID:29756084

Strategies for carbohydrate model building, refinement and validation.

PubMed

Agirre, Jon

2017-02-01

Sugars are the most stereochemically intricate family of biomolecules and present substantial challenges to anyone trying to understand their nomenclature, reactions or branched structures. Current crystallographic programs provide an abstraction layer allowing inexpert structural biologists to build complete protein or nucleic acid model components automatically either from scratch or with little manual intervention. This is, however, still not generally true for sugars. The need for carbohydrate-specific building and validation tools has been highlighted a number of times in the past, concomitantly with the introduction of a new generation of experimental methods that have been ramping up the production of protein-sugar complexes and glycoproteins for the past decade. While some incipient advances have been made to address these demands, correctly modelling and refining carbohydrates remains a challenge. This article will address many of the typical difficulties that a structural biologist may face when dealing with carbohydrates, with an emphasis on problem solving in the resolution range where X-ray crystallography and cryo-electron microscopy are expected to overlap in the next decade.

Youth self-report of child maltreatment in representative surveys: a systematic review

PubMed Central

Jessica, Laurin*; Caroline, Wallace*; Jasminka, Draca; Sarah, Aterman; Lil, Tonmyr

2018-01-01

Abstract Introduction: This systematic review identified population-representative youth surveys containing questions on self-reported child maltreatment. Data quality and ethical issues pertinent to maltreatment data collection were also examined. Methods: A search was conducted of relevant online databases for articles published from January 2000 through March 2016 reporting on population-representative data measuring child maltreatment. Inclusion criteria were established a priori; two reviewers independently assessed articles to ensure that the criteria were met and to verify the accuracy of extracted information. Results: A total of 73 articles reporting on 71 surveys met the inclusion criteria. A variety of strategies to ensure accurate information and to mitigate survey participants’ distress were reported. Conclusion: The extent to which efforts have been undertaken to measure the prevalence of child maltreatment reflects its perceived importance across the world. Data on child maltreatment can be effectively collected from youth, although our knowledge of best practices related to ethics and data quality is incomplete. PMID:29443484

The Empirical Foundations of Teleradiology and Related Applications: A Review of the Evidence

PubMed Central

Krupinski, Elizabeth A.; Thrall, James H.; Bashshur, Noura

2016-01-01

Abstract Introduction: Radiology was founded on a technological discovery by Wilhelm Roentgen in 1895. Teleradiology also had its roots in technology dating back to 1947 with the successful transmission of radiographic images through telephone lines. Diagnostic radiology has become the eye of medicine in terms of diagnosing and treating injury and disease. This article documents the empirical foundations of teleradiology. Methods: A selective review of the credible literature during the past decade (2005–2015) was conducted, using robust research design and adequate sample size as criteria for inclusion. Findings: The evidence regarding feasibility of teleradiology and related information technology applications has been well documented for several decades. The majority of studies focused on intermediate outcomes, as indicated by comparability between teleradiology and conventional radiology. A consistent trend of concordance between the two modalities was observed in terms of diagnostic accuracy and reliability. Additional benefits include reductions in patient transfer, rehospitalization, and length of stay. PMID:27585301

The impact of new vaccine introduction on immunization and health systems: A review of the published literature

PubMed Central

Hyde, Terri B.; Dentz, Holly; Wang, Susan A.; Burchett, Helen E.; Mounier-Jack, Sandra; Mantel, Carsten F.

2015-01-01

We conducted a systematic review of the published literature to examine the impact of new vaccine introduction on countries’ immunization and broader health systems. Six publication databases were searched using 104 vaccine and health system-related search terms. The search yielded 15,795 unique articles dating from December 31, 1911 to September 29, 2010. Based on review of the title and abstract, 654 (4%) of these articles were found to be potentially relevant and were referred for full review. After full review, 130 articles were found to be relevant and included in the analysis. These articles represented vaccines introduced to protect against 10 different diseases (hepatitis A, hepatitis B, Haemophilus influenzae type b disease, human papilloma virus infection, influenza, Japanese encephalitis, meningococcal meningitis, Streptococcus pneumoniae disease, rotavirus diarrhea and typhoid), in various formulations and combinations. Most reviewed articles (97 [75%]) reported experiences in high-income countries. New vaccine introduction was most efficient when the vaccine was introduced into an existing delivery platform and when introduced in combination with a vaccine already in the routine childhood immunization schedule (i.e., as a combination vaccine). New vaccine introduction did not impact coverage of vaccines already included in the routine childhood immunization schedule. The need for increased cold chain capacity was frequently reported. New vaccines facilitated the introduction and widespread use of auto-disable syringes into the immunization and the broader health systems. The importance of training and education for health care workers and social mobilization was frequently noted. There was evidence in high-income countries that new vaccine introduction was associated with reduced health-care costs. Future evaluations of new vaccine introductions should include the systematic and objective assessment of the impacts on a country’s immunization system and broader health system, especially in lower-income countries. PMID:22940378

Using movies in family medicine teaching: A reference to EURACT Educational Agenda

PubMed Central

Švab, Igor

2017-01-01

Abstract Introduction Cinemeducation is a teaching method where popular movies or movie clips are used. We aimed to determine whether family physicians’ competencies as listed in the Educational Agenda produced by the European Academy of Teachers in General Practice/Family Medicine (EURACT) can be found in movies, and to propose a template for teaching by these movies. Methods A group of family medicine teachers provided a list of movies that they would use in cinemeducation. The movies were categorised according to the key family medicine competencies, thus creating a framework of competences, covered by different movies. These key competencies are Primary care management, Personcentred care, Specific problem-solving skills, Comprehensive approach, Community orientation, and Holistic approach. Results The list consisted of 17 movies. Nine covered primary care management. Person-centred care was covered in 13 movies. Eight movies covered specific problem-solving skills. Comprehensive approach was covered in five movies. Five movies covered community orientation. Holistic approach was covered in five movies. Conclusions All key family medicine competencies listed in the Educational Agenda can be taught using movies. Our results can serve as a template for teachers on how to use any appropriate movies in family medicine education. PMID:28289469

An Enzymatic Clinical Chemistry Laboratory Experiment Incorporating an Introduction to Mathematical Method Comparison Techniques

ERIC Educational Resources Information Center

Duxbury, Mark

2004-01-01

An enzymatic laboratory experiment based on the analysis of serum is described that is suitable for students of clinical chemistry. The experiment incorporates an introduction to mathematical method-comparison techniques in which three different clinical glucose analysis methods are compared using linear regression and Bland-Altman difference…

Granular Activated Carbon Performance Capability and Availability.

DTIC Science & Technology

1983-06-01

services were surveyed to determine availability of data and to develop a strategy for later computerized searches: * Chemical Abstracts; * Engineering ...Chemical Abstracts; * Engineering Abstracts; * Environmental Abstracts; * Selected Water Resources Abstracts; * Pollution Abstracts; and * the U.S...chemicals addressed, and scientific and engineering methods used. Publications were also reviewed for quality and consistency with the bulk of available data

StreaMorph: A Case for Synthesizing Energy-Efficient Adaptive Programs Using High-Level Abstractions

DTIC Science & Technology

2013-08-12

technique when switching from using eight cores to one core. 1. Introduction Real - time streaming of media data is growing in popularity. This includes...both capture and processing of real - time video and audio, and delivery of video and audio from servers; recent usage number shows over 800 million...source of data, when that source is a real - time source, and it is generally not necessary to get ahead of the sink. Even with real - time sources and sinks

Manual on the Flight of Flexible Aircraft in Turbulence (Manuel sur le Vol des Avions Non-rigides en Milieu Turbulent)

DTIC Science & Technology

1991-05-01

Static Non-Linearity 106 0 y = f(dx/dt) = -f(-dx/dt) = = > Static Non-Linearity • y = f(x,sign(dx/dt)) = = > Hysteresis-Type Non-Linearity = -f(-x,sign... Havilland Division Garratt Blvd., Downsview Ontario M3K I Y5 Canada CONTENTS ABSTRACT NOTATION 1. INTRODUCTION 2. THE SDG GUST MODEL 3. ESTABLISHING CRITICAL...VENT ETRE ADRESSEES DIRECTEMENT N AU SERVICE NATIONAL TECHNIQUE, Dh INFORMATION (NTIS) DONT LADRESSE SUIT AGENCES DE VENTE National Technical

Atlas/Data Abstract for the United States and Selected Areas, Fiscal Year 1993

DTIC Science & Technology

1993-01-01

and Reports TAN ng N F T P I DTIC AND NTIS IDENTIFICATION NUMBER FOR THIS PUBLICATION IS DIOR/L-03-93. TABLE OF CONTENTS Page INTRODUCTION...Dakota (ND) 35 86 Ohio (OH) 36 88 TABLE OF CONTENTS (Continued) State/Area Map No. Page Oklahoma (OK) 37 90 Oregon (OR) 38 92 Pennsylvania (PA) 39 94...or Service Code Description Amount 1. LORAL CORP $49,319 Operation/Electronic & Communication Facil $48,741 2. DAY & ZIMMERMANN/ BASIL CORP JV 33,368

Domain Processes in Ferroelectric Ceramics

DTIC Science & Technology

1994-04-14

elastic strain tensor and eikl is the Levi - Civita density. Eqs (11) and (12) has three nontrivial solutions: Xr3 = 0 (13) Xr"= -1 { [ 2sj2Q 12 -Sl I...ABSTRACT (aA~iMUM 200 wardt) This report Outlines the progres achieved during a two year effort sponsored by the AFOSR on the theoretical study of domain...INTRODUCTION This is the final progress report for this two year program sponsored by the Air Force Office of Scientific Research on "Domain Processes in

Expanding worldview: Australian nursing students' experience of cultural immersion in India.

PubMed

Charles, Loretta; Maltby, Hendrika; Abrams, Sarah; Shea, Jeanne; Brand, Gabrielle; Nicol, Pamela

2014-01-01

Abstract Increasing cultural diversity and a sense of global community has necessitated the introduction of cultural competence in the education of health care providers. Some institutions have utilised cultural immersion programmes to address this need of cultural competence. Studies have not yet described what this experience is for Australian nursing students. The purpose of this study is to describe the immersion experience of a group of senior Australian nursing students who participated in a 5-week cultural immersion programme in India.

Computer Code for Interpreting 13C NMR Relaxation Measurements with Specific Models of Molecular Motion: The Rigid Isotropic and Symmetric Top Rotor Models and the Flexible Symmetric Top Rotor Model

DTIC Science & Technology

2017-01-01

unlimited. 13. SUPPLEMENTARY NOTES 14. ABSTRACT: Carbon-13 nuclear magnetic resonance (13C NMR) spectroscopy is a powerful technique for...FLEXIBLE SYMMETRIC TOP ROTOR MODEL 1. INTRODUCTION Nuclear magnetic resonance (NMR) spectroscopy is a tremendously powerful technique for...application of NMR spectroscopy concerns the property of molecular motion, which is related to many physical, and even biological, functions of molecules in

Group A rotavirus gastroenteritis: post-vaccine era, genotypes and zoonotic transmission

PubMed Central

Luchs, Adriana; Timenetsky, Maria do Carmo Sampaio Tavares

2016-01-01

ABSTRACT This article provides a review of immunity, diagnosis, and clinical aspects of rotavirus disease. It also informs about the changes in epidemiology of diarrheal disease and genetic diversity of circulating group A rotavirus strains following the introduction of vaccines. Group A rotavirus is the major pathogen causing gastroenteritis in animals. Its segmented RNA genome can lead to the emergence of new or unusual strains in human populations via interspecies transmission and/or reassortment events. PMID:27462899

Extraordinary TCR in Carbon Nanotube-Polymer Composites and Device Implications in Bolometric Infrared Detection

DTIC Science & Technology

2015-03-24

were made via filtration of 1 mL of 1 mg/L SWCNT solution (Nanointegris Inc.) through a 20 nm pore anodized aluminum oxide ( AAO ) membrane filter to...prepared by attaching a rectangular piece cut from the AAO membrane filter onto a glass substrate. Contacts were made with silver paste to the extremities...NUMBER(S) 14. ABSTRACT _ The development of high TCR materials, such as vanadium oxide (VOx), has enabled the introduction of bolometric infrared

Two-Dimensional Electrophoretic Analysis of Subcellular Liver Fractions and Isolated Hepatocytes from Normal and PFDA Treated Rats

DTIC Science & Technology

1990-05-28

Continue on reverse if necessary and identify by block number) FIELD GROUP SUB-GROUP perfluoro.n-decanoic acid ; two-dimensional electrophoresis...hepatotoxicity; cell fractions; liver 1 t ABSTRACT (Continue on reverse if necessary and identify by block number) Perfluoro-n-decanoic acid (PFDA) effects...Unu::’-. ’. I AFOSR Ju .T , Building 410 Bolling AFB, DC 20332-6448 By Dist V’ lml mm mm i INTRODUCTION Perfluorocarboxylic acids and other

ONR Tropical Cyclone Motion Research Initiative; First-Year Review, Discussion and Tentative Hypotheses.

DTIC Science & Technology

1988-02-01

Pacific Network should have 3 to 4 levels of flight level observations and dropwindsonde from research aircraft. An outer box roughly 500 km2 should also...Motion Research Initiative: First. Year Review, Discussion and Tentative Hypotheses : ’ so A.t’oR’,S) Russell L. Elsberry *3j 0V R.OQ 2 ’ 3 .) T’E...Abstract 2 1. Introduction 3 2. Discussion Sessions 5 3 . Tentative Hypotheses 18 4. Preliminary field experiment design considerations 27 5

Vegetation Versus Man-Made Object Detection from Imagery for Unmanned Vehicles in Off-Road Environments

DTIC Science & Technology

2013-05-01

saliency, natural scene statistics 1. INTRODUCTION Research into the area of autonomous navigation for unmanned ground vehicles (UGV) has accelerated in...recent years. This is partly due to the success of programs such as the DARPA Grand Challenge1 and the dream of driverless cars ,2 but is also due to the...NOTES 14. ABSTRACT There have been several major advances in autonomous navigation for unmanned ground vehicles in controlled urban environments in

Expanding Worldview: Australian Nursing Students' Experience of Cultural Immersion in India.

PubMed

Charles, Loretta; Maltby, Hendrika; Abrams, Sarah; Shea, Jeanne; Brand, Gabrielle; Nicol, Pamela

2014-06-27

Abstract Increasing cultural diversity and a sense of global community has necessitated the introduction of cultural competence in the education of health care providers. Some institutions have utilized cultural immersion programs to address this need of cultural competence. Studies have not yet described what this experience is for Australian nursing students. The purpose of this study is to describe the immersion experience of a group of senior Australian nursing students who participated in a five week cultural immersion program in India.

In-Situ Groundwater Treatment Technology Using Biodegradation

DTIC Science & Technology

1987-05-01

ice,� Park Drive, P.O. Box 12297, Research Trianglc Pgrk: NC 1 ?770Q 17. . COSAI COOES IL. SUBJEC TERMS (Coas on MuWMz d1 naicnay &W MO uf by I I, a...OF TABLES v 1 . ABSTRACT 1 2. INTRODUCTION 2 3. SUBSURFACE MICROBIOLOGY 5 3.1 Subsurface Biological Activity 5 3.2 Environmental Factors 5 3.2.1...Sulfate during the First Five Months 30 5.2 Column 1 Effluent Versus Time Data for Carbon Tetrachloride, Bromodichloromethane, and Bromoform during the

Analysis of Zolpidem in Postmortem Fluids and Tissues Using Ultra-Performance Liquid Chromatography-Mass Spectrometry

DTIC Science & Technology

2014-02-01

16. Abstract Zolpidem is a nonbenzodiazepine sedative hypnotic drug used for the short-term treatment of insomnia. Its use is common and wide-spread...Classif. (of this page) 21. No. of Pages 22. Price Unclassified Unclassified 15 Form DOT F 1700.7 (8-72) Reproduction of completed page authorized iii...INTRODUCTION Zolpidem is a nonbenzodiazepine sedative hypnotic drug used to treat insomnia by slowing the activity in the brain. It is prescribed as a short

Electromagnetic Fields of a Uniform Sphere in a Uniform Conducting Medium with Application to Dipole Sources

DTIC Science & Technology

1991-09-01

12b. DISTRIBUTION CODE Approved for public release; distribution is unlimited. 13. ABSTRACT (Maximum 200 words) Vector spherical harmonic expansions are...electric and magnetic field vectors from E rand B - r alone. Genural expressions are given relating the scattered field expansion coefficients to the source...Prescnbed by ANSI Std. Z39-18 29W-102 NCSC TR 426-90 CONTENTS Pag o INTRODUCTION 1 BACKGROUND 1 ANGULAR MOMENTUM OPERATOR AND VECTOR SPHERICAL

An Appraisal of a Number of Power Assessment Procedures being Proposed for Use in Chinook-Lycoming T55 Engine

DTIC Science & Technology

1989-02-01

WHICH WILL NOT BE ADDED TO THE DISTIS DATA UNLESS SPECIFICA.LLY REQUESTED. 16. ABSTRACT (CONT.) control ( FADEC ) to the T55-Lll engine. This latter...the Power Assurance Test (PAT) proposed in conjunction with the retrofitting of a full authority digital engine control ( FADEC ) to the T55-Lll engine...Research Laboratory, P.Q. Bcx 4331, felbourne, Victoria, 3001, A..sLralia CONTENTS Page NOMENCLATURE 1.0 INTRODUCTION ........................ 1 2.0 FADEC

Iron-Isotopic Fractionation Studies Using Multiple Collector Inductively Coupled Plasma Mass Spectrometry

NASA Technical Reports Server (NTRS)

Anbar, A. D.; Zhang, C.; Barling, J.; Roe, J. E.; Nealson, K. H.

1999-01-01

The importance of Fe biogeochemistry has stimulated interest in Fe isotope fractionation. Recent studies using thermal ionization mass spectrometry (TIMS) and a "double spike" demonstrate the existence of biogenic Fe isotope effects. Here, we assess the utility of multiple-collector inductively-coupled plasma mass spectrometry(MC-ICP-MS) with a desolvating sample introduction system for Fe isotope studies, and present data on Fe biominerals produced by a thermophilic bacterium. Additional information is contained in the original extended abstract.

Ocean Current Effects on Marine Seismic Systems and Deployments.

DTIC Science & Technology

1982-01-01

UNCLASSIFIED NOROA-TN 132 N 44, i . 4- iv L~~~ Kr~4~ !jj A r qt4 : ~’~A71 I0 AII ABSTRACT Upper level and near bottom current measurements were made...indicated a variable yet generally slow 1 " current regime which posed minimal threat of cable entanglement. Current [ measurements made 5 m off bottom during...diameters a iv -ALI-- - 1. 1. Introduction Two types of physical oceanographic measurements were supplied by NORDA Code 331 In support of the March-April

An Asteroid and its Moon Observed with LGS at the SOR

DTIC Science & Technology

2015-10-18

An Asteroid and its Moon Observed with LGS at the SOR1 Jack Drummond, Odell Reynolds, and Miles Buckman Air Force Research Laboratory, Directed...Energy Directorate, RDSS 3550 Aberdeen Ave SE, Kirtland AFB, NM 87117-5776 ABSTRACT The faint moon , Romulus, around the main belt asteroid (87) Sylvia was...approaching a larger one, and make our 3.5 m telescope the smallest ground-based telescope to ever image any asteroids moon . 1. Introduction For the past few

Preliminary Hydrodynamic Model Tests of Several LVA Planing Hull Concepts

DTIC Science & Technology

1975-10-01

OF CONTENTS Page ABSTRACT ii INTRODUCTION 1 MODELS AND APPARATUS 2 TEST PROCEDURE 4 TEST RESULTS 6 Smooth Water Results 6 Rough Water...07’«6, Project NR 062-510. Technical monitoring was provided by the LVA office at NSRDC. R-18A0 - 2 - MODELS AND APPARATUS The test models were 1 /12...which have not been considered in this study. Tables 1 , 2 and 3 and Figures *», 5 and 6 represent results for the inverted vee-bottom (model P-l

21ST International Symposium on Rarefied Gas Dynamics, Marseille (France) 26-31 July 1998. Book of Abstracts, Volume I: Oral Sessions.

DTIC Science & Technology

1998-07-30

properties of gases, there are some major ite Gases, Academic Press, New York (1969). defects common to gas kinetic treatments. In hy- (1988). drodynamic...the incondensable gas are Recently, serious defects in classical gasdynamics comparable. in describing the behavior of a gas in the contin- We use the...Transition of Hypersonic, Chemically Reacting Boundary Layers J. Perraud, D. Arnal, F. Thivet ONERA CERT, DMAE , Toulouse, France 1 Introduction of

47 CFR 2.1501 - Introduction.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 47 Telecommunication 1 2010-10-01 2010-10-01 false Introduction. 2.1501 Section 2.1501 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL FREQUENCY ALLOCATIONS AND RADIO TREATY MATTERS; GENERAL... Radiobeacons (EPIRBs) General § 2.1501 Introduction. The procedure described herein sets forth uniform methods...

Evaluation of introduction of the Haemophilus influenzae vaccine in Côte d’Ivoire

PubMed

Yohou, Kévin Sylvestre; Aka, Nicaise Lepri; Noufe, Soualihou; Douba, Alfred; Assi Assi, Bernard; Dagnan, Simplice N Cho

2016-11-25

Introduction: Côte d’Ivoire introduced the Haemophilus influenzae type b vaccine into the EPI in March 2009. Following this introduction, an evaluation was conducted in 2012 in order to evaluate the vaccine introduction process. Methods: Data collection methods consisted of document review, structured interviews and direct observation. This study collected information from six health region officials, 12 health districts and 36 healthcare institutions. Seventy-two mothers or child carers were also interviewed. Collected data were processed and analysed by Excel, Epi Info and SPSS. Results: A vaccine introduction plan was developed, but was not communicated at the operational level. The planned training for district health care providers was conducted eighteen months after introduction of the vaccine. None of the vaccinating centres had communication support about the new vaccine. Temperature recording was regularly performed in 92% of district deposits and 68% of vaccinating centres. Deteriorated vaccines were observed in 6% of vaccinating centres. Only 3.5% of parents had been informed about introduction of the vaccine. Increased immunization coverage for the third dose of pentavalent vaccine was observed in one half of health districts. Conclusion: Evaluation of the introduction of Haemophilus influenzae type b vaccine highlightsthe strengths and weaknesses of the health system and provides lessons for the introduction of other vaccines into the expanded programme on immunization.

Abstract Interpreters for Free

NASA Astrophysics Data System (ADS)

Might, Matthew

In small-step abstract interpretations, the concrete and abstract semantics bear an uncanny resemblance. In this work, we present an analysis-design methodology that both explains and exploits that resemblance. Specifically, we present a two-step method to convert a small-step concrete semantics into a family of sound, computable abstract interpretations. The first step re-factors the concrete state-space to eliminate recursive structure; this refactoring of the state-space simultaneously determines a store-passing-style transformation on the underlying concrete semantics. The second step uses inference rules to generate an abstract state-space and a Galois connection simultaneously. The Galois connection allows the calculation of the "optimal" abstract interpretation. The two-step process is unambiguous, but nondeterministic: at each step, analysis designers face choices. Some of these choices ultimately influence properties such as flow-, field- and context-sensitivity. Thus, under the method, we can give the emergence of these properties a graph-theoretic characterization. To illustrate the method, we systematically abstract the continuation-passing style lambda calculus to arrive at two distinct families of analyses. The first is the well-known k-CFA family of analyses. The second consists of novel "environment-centric" abstract interpretations, none of which appear in the literature on static analysis of higher-order programs.

Sickle cell disease

PubMed Central

2016-01-01

Introduction Sickle cell disease causes chronic haemolytic anaemia, dactylitis, and painful acute crises. It also increases the risk of stroke, organ damage, bacterial infections, and complications of blood transfusion. In sub-Saharan Africa, up to one third of adults are carriers of the defective sickle cell gene, and 1% to 2% of babies are born with the disease. Methods and outcomes We conducted a systematic overview, aiming to answer the following clinical question: What are the effects of pharmaceutical interventions to prevent sickle cell crisis and other acute complications in people with sickle cell disease? We searched: Medline, Embase, The Cochrane Library, and other important databases up to January 2015 (BMJ Clinical Evidence overviews are updated periodically; please check our website for the most up-to-date version of this overview). Results At this update, searching of electronic databases retrieved 369 studies. After deduplication and removal of conference abstracts, 136 records were screened for inclusion in the overview. Appraisal of titles and abstracts led to the exclusion of 99 studies and the further review of 37 full publications. Of the 37 full articles evaluated, three already included systematic reviews were updated, two systematic reviews, two RCTs, and one subsequent RCT were added at this update. We performed a GRADE evaluation for 12 PICO combinations. Conclusions In this systematic overview, we categorised the efficacy for five interventions based on information about the effectiveness and safety of antibiotic prophylaxis in children aged under 5 years, antibiotic prophylaxis in children aged 5 years or older, hydroxyurea, malaria chemoprophylaxis, and pneumococcal vaccines. PMID:26808098

Contraceptive introduction and the management of choice: the role of Cyclofem in Indonesia.

PubMed

Simmons, R; Fajans, P; Lubis, F

1994-05-01

This paper presents a programmatic perspective on the relationship between the introduction of new contraceptive technology and expanding contraceptive options, using the example of Cyclofem in Indonesia. Past approaches to contraceptive introduction have considered only the characteristics of the new method in the decision-making process. In assessing whether the introduction of a new method actually expands contraceptive choice for women and whether the program has the managerial capabilities to assure quality of care in this process, the authors argue that consideration must be given to all methods within a delivery system and how new technology relates to the management of contraceptive choice. Using this perspective, the authors suggest that choice would not necessarily be expanded with scaled-up service delivery of a new once-a month injectable in the Indonesian public sector context.

[Trends of research articles in the Korean Journal of Medical Education by social network analysis].

PubMed

Yoo, Hyo Hyun; Shin, Sein

2015-12-01

This aim of this study is to examine trends in medical education research in the Korean Journal of Medical Education(KJME) and suggest improvements for medical education research. The main variables were keywords from research papers that were published in KJME. Abstracts of papers (n=499) that were published from 1991 through 2015 were analyzed by social network analysis (NetMiner 4.0) a common research methodfor trends in academic subjects. The most central keywords were "medical education," "clinical competence," "medical student," and "curriculum." After introduction into graduate medical school, newly appearing keywords were "professional behavior," "medical humanities," "communication,"and "physician-patient relation." Based on these results, we generated a schematic of the network, in which the five groups before introduction to graduate medical school expanded to nine groups after introduction. Medical education research has been improving qualitatively and quantitatively, and research subjects have been expanded, subdivided, and specific. While KJME has encompassed medical education studies comprehensively, studies on medical students have risen in number. Thus, the studies that are published in KJME were consistent with the direction of journal and a new study on the changes in medical education is being conducted.

Editors' Introduction to the Thematic Issue: Mad about Methods? Teaching Research Methods in Political Science

ERIC Educational Resources Information Center

Adriaensen, Johan; Kerremans, Bart; Slootmaeckers, Koen

2015-01-01

The contributors to this special issue all seek to address the challenge of teaching research methods to political science students. This introduction aims to provide a concise framework for the various innovations presented throughout this issue, situating them in the wider literature. Particular emphasis is placed on the factors that distinguish…

GOClonto: an ontological clustering approach for conceptualizing PubMed abstracts.

PubMed

Zheng, Hai-Tao; Borchert, Charles; Kim, Hong-Gee

2010-02-01

Concurrent with progress in biomedical sciences, an overwhelming of textual knowledge is accumulating in the biomedical literature. PubMed is the most comprehensive database collecting and managing biomedical literature. To help researchers easily understand collections of PubMed abstracts, numerous clustering methods have been proposed to group similar abstracts based on their shared features. However, most of these methods do not explore the semantic relationships among groupings of documents, which could help better illuminate the groupings of PubMed abstracts. To address this issue, we proposed an ontological clustering method called GOClonto for conceptualizing PubMed abstracts. GOClonto uses latent semantic analysis (LSA) and gene ontology (GO) to identify key gene-related concepts and their relationships as well as allocate PubMed abstracts based on these key gene-related concepts. Based on two PubMed abstract collections, the experimental results show that GOClonto is able to identify key gene-related concepts and outperforms the STC (suffix tree clustering) algorithm, the Lingo algorithm, the Fuzzy Ants algorithm, and the clustering based TRS (tolerance rough set) algorithm. Moreover, the two ontologies generated by GOClonto show significant informative conceptual structures.

The Economic Burden Attributable to a Child’s Inpatient Admission for Diarrheal Disease in Rwanda

PubMed Central

Ngabo, Fidele; Mvundura, Mercy; Gazley, Lauren; Gatera, Maurice; Rugambwa, Celse; Kayonga, Eugene; Tuyishime, Yvette; Niyibaho, Jeanne; Mwenda, Jason M.; Donnen, Philippe; Lepage, Philippe; Binagwaho, Agnes; Atherly, Deborah

2016-01-01

Background Diarrhea is one of the leading causes of childhood morbidity and mortality. Hospitalization for diarrhea can pose a significant burden to health systems and households. The objective of this study was to estimate the economic burden attributable to hospitalization for diarrhea among children less than five years old in Rwanda. These data can be used by decision-makers to assess the impact of interventions that reduce diarrhea morbidity, including rotavirus vaccine introduction. Methods This was a prospective costing study where medical records and hospital bills for children admitted with diarrhea at three hospitals were collected to estimate resource use and costs. Hospital length of stay was calculated from medical records. Costs incurred during the hospitalization were abstracted from the hospital bills. Interviews with the child’s caregivers provided data to estimate household costs which included transport costs and lost income. The portion of medical costs borne by insurance and household were reported separately. Annual economic burden before and after rotavirus vaccine introduction was estimated by multiplying the reported number of diarrhea hospitalizations in public health centers and district hospitals by the estimated economic burden per hospitalization. All costs are presented in 2014 US$. Results Costs for 203 children were analyzed. Approximately 93% of the children had health insurance coverage. Average hospital length of stay was 5.3 ± 3.9 days. Average medical costs for each child for the illness resulting in a hospitalization were $44.22 ± $23.74 and the total economic burden was $101, of which 65% was borne by the household. For households in the lowest income quintile, the household costs were 110% of their monthly income. The annual economic burden to Rwanda attributable to diarrhea hospitalizations ranged from $1.3 million to $1.7 million before rotavirus vaccine introduction. Conclusion Households often bear the largest share of the economic burden attributable to diarrhea hospitalization and the burden can be substantial, especially for households in the lowest income quintile. PMID:26901113

Avoiding dangerous climate change

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hans Joachim Schellnhuber; Wolfgang Cramer; Nebojsa Nakicenovic

2006-02-15

In 2005 the UK Government hosted the Avoiding Dangerous Climate Change conference to take an in-depth look at the scientific issues associated with climate change. This volume presents the most recent findings from the leading international scientists that attended the conference. The topics addressed include critical thresholds and key vulnerabilities of the climate system, impacts on human and natural systems, socioeconomic costs and benefits of emissions pathways, and technological options for meeting different stabilisation levels of greenhouse gases in the atmosphere. Contents are: Foreword from Prime Minister Tony Blair; Introduction from Rajendra Pachauri, Chairman of the IPCC; followed by 41more » papers arranged in seven sections entitled: Key Vulnerabilities of the Climate System and Critical Thresholds; General Perspectives on Dangerous Impacts; Key Vulnerabilities for Ecosystems and Biodiversity; Socio-Economic Effects; Regional Perspectives; Emission Pathways; and Technological Options. Four papers have been abstracted separately for the Coal Abstracts database.« less

Deciphering the Epigenetic Code: An Overview of DNA Methylation Analysis Methods

PubMed Central

Umer, Muhammad

2013-01-01

Abstract Significance: Methylation of cytosine in DNA is linked with gene regulation, and this has profound implications in development, normal biology, and disease conditions in many eukaryotic organisms. A wide range of methods and approaches exist for its identification, quantification, and mapping within the genome. While the earliest approaches were nonspecific and were at best useful for quantification of total methylated cytosines in the chunk of DNA, this field has seen considerable progress and development over the past decades. Recent Advances: Methods for DNA methylation analysis differ in their coverage and sensitivity, and the method of choice depends on the intended application and desired level of information. Potential results include global methyl cytosine content, degree of methylation at specific loci, or genome-wide methylation maps. Introduction of more advanced approaches to DNA methylation analysis, such as microarray platforms and massively parallel sequencing, has brought us closer to unveiling the whole methylome. Critical Issues: Sensitive quantification of DNA methylation from degraded and minute quantities of DNA and high-throughput DNA methylation mapping of single cells still remain a challenge. Future Directions: Developments in DNA sequencing technologies as well as the methods for identification and mapping of 5-hydroxymethylcytosine are expected to augment our current understanding of epigenomics. Here we present an overview of methodologies available for DNA methylation analysis with special focus on recent developments in genome-wide and high-throughput methods. While the application focus relates to cancer research, the methods are equally relevant to broader issues of epigenetics and redox science in this special forum. Antioxid. Redox Signal. 18, 1972–1986. PMID:23121567

Abstracting Concepts and Methods.

ERIC Educational Resources Information Center

Borko, Harold; Bernier, Charles L.

This text provides a complete discussion of abstracts--their history, production, organization, publication--and of indexing. Instructions for abstracting are outlined, and standards and criteria for abstracting are stated. Management, automation, and personnel are discussed in terms of possible economies that can be derived from the introduction…

Catalytic, Enantioselective Sulfenofunctionalisation of Alkenes: Mechanistic, Crystallographic, and Computational Studies

PubMed Central

Denmark, Scott E.; Hartmann, Eduard; Kornfilt, David J. P.; Wang, Hao

2015-01-01

The stereocontrolled introduction of vicinal heteroatomic substituents into organic molecules is one of the most powerful ways of adding value and function. Whereas many methods exist for the introduction of oxygen- and nitrogen-containing substituents, the number stereocontrolled methods for the introduction of sulfur-containing substituents pales by comparison. Previous reports from these laboratories have described the sulfenofunctionalization of alkenes that construct vicinal carbon-sulfur and carbon-oxygen, carbon-nitrogen as well as carbon-carbon bonds with high levels of diastereospecificity and enantioselectivity. This process is enabled by the concept of Lewis base activation of Lewis acids that provides activation of Group 16 electrophiles. To provide a foundation for expansion of substrate scope and improved selectivities, we have undertaken a comprehensive study of the catalytically active species. Insights gleaned from kinetic, crystallographic and computational methods have led to the introduction of a new family of sulfenylating agents that provide significantly enhanced selectivities. PMID:25411883

Quantitative real-time monitoring of multi-elements in airborne particulates by direct introduction into an inductively coupled plasma mass spectrometer

NASA Astrophysics Data System (ADS)

Suzuki, Yoshinari; Sato, Hikaru; Hiyoshi, Katsuhiro; Furuta, Naoki

2012-10-01

A new calibration system for real-time determination of trace elements in airborne particulates was developed. Airborne particulates were directly introduced into an inductively coupled plasma mass spectrometer, and the concentrations of 15 trace elements were determined by means of an external calibration method. External standard solutions were nebulized by an ultrasonic nebulizer (USN) coupled with a desolvation system, and the resulting aerosol was introduced into the plasma. The efficiency of sample introduction via the USN was calculated by two methods: (1) the introduction of a Cr standard solution via the USN was compared with introduction of a Cr(CO)6 standard gas via a standard gas generator and (2) the aerosol generated by the USN was trapped on filters and then analyzed. The Cr introduction efficiencies obtained by the two methods were the same, and the introduction efficiencies of the other elements were equal to the introduction efficiency of Cr. Our results indicated that our calibration method for introduction efficiency worked well for the 15 elements (Ti, V, Cr, Mn, Co, Ni, Cu, Zn, As, Mo, Sn, Sb, Ba, Tl and Pb). The real-time data and the filter-collection data agreed well for elements with low-melting oxides (V, Co, As, Mo, Sb, Tl, and Pb). In contrast, the real-time data were smaller than the filter-collection data for elements with high-melting oxides (Ti, Cr, Mn, Ni, Cu, Zn, Sn, and Ba). This result implies that the oxides of these 8 elements were not completely fused, vaporized, atomized, and ionized in the initial radiation zone of the inductively coupled plasma. However, quantitative real-time monitoring can be realized after correction for the element recoveries which can be calculated from the ratio of real-time data/filter-collection data.

Creating Simulations for An "Introduction to Research Methods" Course

ERIC Educational Resources Information Center

Adamson, Bob

2010-01-01

This paper describes the production of a software program for Master of Education students studying the "Introduction to Research Methods" course at a tertiary institution in Hong Kong. The course was originally delivered in a lecture mode, which proved unsatisfactory in providing sufficient learning support for the students. The paper…

An introduction to Lie group integrators – basics, new developments and applications

DOE Office of Scientific and Technical Information (OSTI.GOV)

Celledoni, Elena, E-mail: elenac@math.ntnu.no; Marthinsen, Håkon, E-mail: hakonm@math.ntnu.no; Owren, Brynjulf, E-mail: bryn@math.ntnu.no

2014-01-15

We give a short and elementary introduction to Lie group methods. A selection of applications of Lie group integrators are discussed. Finally, a family of symplectic integrators on cotangent bundles of Lie groups is presented and the notion of discrete gradient methods is generalised to Lie groups.

Assessing the impacts of water abstractions on river ecosystem services: an eco-hydraulic modelling approach

DOE Office of Scientific and Technical Information (OSTI.GOV)

Carolli, Mauro, E-mail: mauro.carolli@unitn.it; Geneletti, Davide, E-mail: davide.geneletti@unitn.it; Zolezzi, Guido, E-mail: guido.zolezzi@unitn.it

The provision of important river ecosystem services (ES) is dependent on the flow regime. This requires methods to assess the impacts on ES caused by interventions on rivers that affect flow regime, such as water abstractions. This study proposes a method to i) quantify the provision of a set of river ES, ii) simulate the effects of water abstraction alternatives that differ in location and abstracted flow, and iii) assess the impact of water abstraction alternatives on the selected ES. The method is based on river modelling science, and integrates spatially distributed hydrological, hydraulic and habitat models at different spatialmore » and temporal scales. The method is applied to the hydropeaked upper Noce River (Northern Italy), which is regulated by hydropower operations. We selected locally relevant river ES: habitat suitability for the adult marble trout, white-water rafting suitability, hydroelectricity production from run-of-river (RoR) plants. Our results quantify the seasonality of river ES response variables and their intrinsic non-linearity, which explains why the same abstracted flow can produce different effects on trout habitat and rafting suitability depending on the morphology of the abstracted reach. An economic valuation of the examined river ES suggests that incomes from RoR hydropower plants are of comparable magnitude to touristic revenue losses related to the decrease in rafting suitability.« less

A Supply and Demand Management Perspective on the Accelerated Global Introductions of Inactivated Poliovirus Vaccine in a Constrained Supply Market

PubMed Central

Ottosen, Ann; Rubin, Jennifer; Blanc, Diana Chang; Zipursky, Simona; Wootton, Emily

2017-01-01

Abstract A total of 105 countries have introduced IPV as of September 2016 of which 85 have procured the vaccine through UNICEF. The Global Eradication and Endgame Strategic Plan 2013-2018 called for the rapid introduction of at least one dose of IPV into routine immunization schedules in 126 all OPV-using countries by the end of 2015. At the time of initiating the procurement process, demand was estimated based on global modeling rather than individual country indications. In its capacity as procurement agency for the Global Polio Eradication Initiative and Gavi, the Vaccine Alliance, UNICEF set out to secure access to IPV supply for around 100 countries. Based on offers received, sufficient supply was awarded to two manufacturers to meet projected routine requirements. However, due to technical issues scaling up vaccine production and an unforecasted demand for IPV use in campaigns to interrupt wild polio virus and to control type 2 vaccine derived polio virus outbreaks, IPV supplies are severely constrained. Activities to stretch supplies and to suppress demand have been ongoing since 2014, including delaying IPV introduction in countries where risks of type 2 reintroduction are lower, implementing the multi-dose vial policy, and encouraging the use of fractional dose delivered intradermally. Despite these efforts, there is still insufficient IPV supply to meet demand. The impact of the supply situation on IPV introduction timelines in countries are the focus of this article, and based on lessons learned with the IPV introductions, it is recommended for future health programs with accelerated scale up of programs, to take a cautious approach on supply commitments, putting in place clear allocation criteria in case of shortages or delays and establishing a communication strategy vis a vis beneficiaries. PMID:28838159

Simultaneous Breast Expression in Breastfeeding Women Is More Efficacious Than Sequential Breast Expression

PubMed Central

Garbin, Catherine P.; Hartmann, Peter E.; Kent, Jacqueline C.

2012-01-01

Abstract Introduction Simultaneous (SIM) breast expression saves mothers time compared with sequential (SEQ) expression, but it remains unclear whether the two methods differ in milk output efficiency and efficacy. Subjects and Methods The Showmilk device (Medela AG, Baar, Switzerland) was used to measure milk output and milk ejection during breast expression (electric pump) in 31 Australian breastfeeding mothers of term infants (median age, 19 weeks [interquartile range, 10–33 weeks]). The order of expression type (SIM/SEQ) and breast (left/right) was randomized. Results SIM expression yielded more milk ejections (p≤0.001) and greater amounts of milk at 2, 5, and 10 minutes (p≤0.01) and removed a greater total amount of milk (p≤0.01) and percentage of available milk (p<0.05) than SEQ expression. After SIM expression the cream content of both the overall (8.3% [p≤0.05]) and postexpression (12.6% [p≤0.001]) milk were greater. During SEQ expression, the breast expressed first had a shorter time to 50% and 80% of the total amount of milk than the breast expressed second (p≤0.05), but, overall, a similar percentage of available milk was removed from both breasts. Conclusions SIM expression stimulated more milk ejections and was a more efficient and efficacious method of expression, yielding milk with a higher energy content. PMID:23039397

[Spiral CT angiography in practice].

PubMed

Pavcec, Zlatko; Zokalj, Ivan; Rumboldt, Zoran; Pal, Andrej; Saghir, Hussein; Ozretić, David; Latin, Branko; Perhoć, Zeljka; Marotti, Miljenko

2005-01-01

Incidence of vascular diseases and development of new radiologic techniques in the last three decades has given strong impuls for introduction of non-invasive vascular diagnostic methods. Thanks to the introduction of Doppler ultrasound, new types of computed tomography (CT) and magnetic resonance (MR) scanners, non-invasive vascular diagnostic methods are replacing conventional invasive (catheter) angiographic methods. Computed tomographic angiography (CTA) is a noninvasive vascular diagnostic method based on continuous scanning with CT scanner during intravenous application of contrast material. Performing of CTA is possible after introduction of spiral CT technique whose characteristics are short imaging time and volumetric data acquisition. The main goal of this article, based on our experiences, is to review the role of CTA, performed on single-slice CT scanner, in managment of patients with vascular pathology.

Entity Profiling for Intelligence Using the Graphical Overview of Social and Semantic Interactions of People (GOSSIP) Software Tool

DTIC Science & Technology

2010-11-01

TR 2010-188; R & D pour la défense Canada – Toronto; Novembre 2010. Introduction ou contexte : En règle générale, l’analyste du renseignement ou...model humans Series3 DRDC Toronto TR 2010-188 13 Figure 4. continued. Profiles for famous names generated by subjects and the model...document is classified) 13 . ABSTRACT (A brief and factual summary of the document. It may also appear elsewhere in the body of the document itself. It is

Collaborative Research and Development (CR&D). Delivery Order 0031: Basic Research and Development of Ti-B Alloys

DTIC Science & Technology

2006-09-01

September 2005 Abstract The grain size of as-cast Ti- 6Al - 4V is reduced by about an order of magnitude from 1700 to 200 /lm with an addition of 0.1 wt...and enhances subsequent mechanical working response [l J. The grain sizes of conventional cast titanium alloys (e.g, Ti-6AI- 4V ) are rather coarse...microstructure; Serial sectioning 1. Introduction The addition of boron to titanium alloys such as Ti­ 6AI- 4V can significantly enhance their strength

DNA nanotechnology and fluorescence applications.

PubMed

Schlichthaerle, Thomas; Strauss, Maximilian T; Schueder, Florian; Woehrstein, Johannes B; Jungmann, Ralf

2016-06-01

Structural DNA nanotechnology allow researchers to use the unique molecular recognition properties of DNA strands to construct nanoscale objects with almost arbitrary complexity in two and three dimensions. Abstracted as molecular breadboards, DNA nanostructures enable nanometer-precise placement of guest molecules such as proteins, fluorophores, or nanoparticles. These assemblies can be used to study biological phenomena with unprecedented control over number, spacing, and molecular identity. Here, we give a general introduction to structural DNA nanotechnology and more specifically discuss applications of DNA nanostructures in the field of fluorescence and plasmonics. Copyright © 2016 Elsevier Ltd. All rights reserved.

You are a Stranger! Examining the Process of Swift Trust Formation in Global Virtual Teams Using Team Model and Cross-Cultural Theoretical Framework

DTIC Science & Technology

2017-01-18

cu.ac.jp Period of Performance: September/30/2014– September/30/2016 Abstract: Traditionally, a team has been defined as a group of people that...INTRODUCTION Traditionally, a team has been defined as a group of people that meet face-to-face to achieve a common goal. Yet the past two decades have...are conducive to developing trust quickly in the absence of a strong “in- group .” GVTs working for MNCs are also assembled differently from

Reuseable Objects Software Environment (ROSE): Introduction to Air Force Software Reuse Workshop

NASA Technical Reports Server (NTRS)

Cottrell, William L.

1994-01-01

The Reusable Objects Software Environment (ROSE) is a common, consistent, consolidated implementation of software functionality using modern object oriented software engineering including designed-in reuse and adaptable requirements. ROSE is designed to minimize abstraction and reduce complexity. A planning model for the reverse engineering of selected objects through object oriented analysis is depicted. Dynamic and functional modeling are used to develop a system design, the object design, the language, and a database management system. The return on investment for a ROSE pilot program and timelines are charted.

Abstract of talk for Silicon Valley Linux Users Group

NASA Technical Reports Server (NTRS)

Clanton, Sam

2003-01-01

The use of Linux for research at NASA Ames is discussed.Topics include:work with the Atmospheric Physics branch on software for a spectrometer to be used in the CRYSTAL-FACE mission this summer; work on in the Neuroengineering Lab with code IC including an introduction to the extension of the human senses project,advantages with using linux for real-time biological data processing,algorithms utilized on a linux system, goals of the project,slides of people with Neuroscan caps on, and progress that has been made and how linux has helped.

A Genome-Wide Identified Risk Variant for PTSD is a Methylation Quantitative Trait Locus and Confers Decreased Cortical Activation to Fearful Faces

DTIC Science & Technology

2015-05-18

Department of Defense; Grant numbers: W81XWH-09-2-0044, W911NF-09-1-0298; Grant sponsor: Emory and Grady Memorial Hospital General Clinical Research...TERMS GWAS; PTSD; fMRI ; meQTL; epigenetic 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT Same as Report (SAR) 18. NUMBER OF PAGES 10...that contribute to this disorder. 2015 Wiley Periodicals, Inc. Key words: GWAS; PTSD; fMRI ; meQTL; epigenetic INTRODUCTION Although post-traumatic

Investment Criteria for Airport Surveillance Radar, Air Traffic Control Radar Beacon System, and Automated Radar Terminal System (ASR/ATCRBS/ARTS)

DTIC Science & Technology

1983-05-01

15 FIQGX 4 Tine Saved By ASR: 3 Mile vs. 7.5 Mile Separation 40 3 4 S10" 6 ;9 q4, ItI I ILI 10! i~o 2 _ _P𔃻_ _ P_ _ IFR HUM 16 :,.4eS _OE_ AT_...8217 16 . Abstract ""This report develops revised investment criteria for Airport Survoiillance Radar, Air Traffic Control Radar Beacon System, and...12 A. Introduction. .................... 1. 32 B. IFR Delay Reduction Benefits ...... ............. 13 C. Safety Benefits

Non-Tactical Vehicle Replacement for the Department of the Navy’s Medium- and Heavy-Duty Vehicle Fleet

DTIC Science & Technology

2016-12-01

Form Approved OMB No. 0704–0188 Public reporting burden for this collection of information is estimated to average 1 hour per response, including the...ABSTRACT UU NSN 7540–01-280-5500 Standard Form 298 (Rev. 2–89) Prescribed by ANSI Std. 239–18 ii THIS PAGE INTENTIONALLY LEFT BLANK iii...BLANK 1 I. INTRODUCTION The sooner we get started with alternative energy sources and recognize that fossil fuels makes us less secure as a nation

Heterocycles Based on Group III, IV, and V Elements, Precursors for Novel Glasses and Ceramics

DTIC Science & Technology

1990-08-01

OF TABLES v LIST OF FIGURES vi 1. ABSTRACT 1 2. INTRODUCTION 3 3. RESULTS AND DISCUSSION 5 3.1 Synthesis and Thermolysis of Aluminum...Chloride.Hexamethyldisilazane Adduct 5 3.2 Synthesis and Reactions of Bis(trimethylsilyl)- aminoaluminum Compounds 11 3.3 Reactions of Tris[bis(trimethylsilyl)amino...Et3N.C12AIN(SiMe3 )B(NH2 )NHSiMe3 , a processible precursor to AlN.BN ceramic. Attempts at synthesis of other AlN.BN precursors and AINP systems were

Introduction to special issue on burnout and health.

PubMed

Schaufeli, W B; Greenglass, E R

2001-09-01

Abstract In recent years, the issue of occupational stress and burnout have received increasing research attention. Given the amount of time people spend on work-related activities and the central importance of work to one's sense of identity and self-worth, it is not surprising that occupational stress is regarded as a central area of study. Although burnout is linked to the extensive literature on occupational health, burnout goes beyond occupational health by focusing on specific stressors in the workplace to emphasize total life and environmental pressures affecting health.

High Tc superconducting bolometric and nonbolometric infrared (IR) detectors

NASA Technical Reports Server (NTRS)

Lakeou, Samuel

1994-01-01

The original workplan for the first year of the project includes the following: establishment of a pilot superconductivity application laboratory at UDC to support the research component of the project; research on the source of electrical noise in High Tc superconducting films in order to optimize the film microstructure and lower the NEP; and lay the foundation of an academic support for exposing UDC students to the theory and application of High Tc superconductivity. Attached to this status report are abstracts and the course description for Introduction to Applications of Superconductivity.

Continuous system modeling

NASA Technical Reports Server (NTRS)

Cellier, Francois E.

1991-01-01

A comprehensive and systematic introduction is presented for the concepts associated with 'modeling', involving the transition from a physical system down to an abstract description of that system in the form of a set of differential and/or difference equations, and basing its treatment of modeling on the mathematics of dynamical systems. Attention is given to the principles of passive electrical circuit modeling, planar mechanical systems modeling, hierarchical modular modeling of continuous systems, and bond-graph modeling. Also discussed are modeling in equilibrium thermodynamics, population dynamics, and system dynamics, inductive reasoning, artificial neural networks, and automated model synthesis.

The Introduction of Non-Verbal Communication in Greek Education: A Literature Review

ERIC Educational Resources Information Center

Stamatis, Panagiotis J.

2012-01-01

Introduction: The introductory part of this paper underlines the research interest of the educational community in the issue of non-verbal communication in education. The question for the introduction of this scientific field in Greek education enter within the context of this research which include many aspects. Method: The paper essentially…

Implementation of Markerless Augmented Reality Technology Based on Android to Introduction Lontara in Marine Society

NASA Astrophysics Data System (ADS)

Jumarlis, Mila; Mirfan, Mirfan

2018-05-01

Local language learning had been leaving by people especially young people had affected technology advances so that involved lack of interest to learn culture especially local language. So required interactive and interest learning media for introduction Lontara. This research aims to design and implement augmented reality on introduction Lontara on mobile device especially android. Application of introduction Lontara based on Android was designed by Vuforia and Unity. Data collection method were observation, interview, and literature review. That data was analysed for being information. The system was designed by Unified Modeling Language (UML). The method used is a marker. The test result found that application of Augmented Reality on introduction Lontara based on Android could improve public interest for introducing local language particularly young people in learning about Lontara because of using technology. Application of introduction of Lontara based on Android used augmented reality occurred sound and how to write Lontara with animation. This application could be running without an internet connection, so that its used more efficient and could maximize from user.

Introduction to the Management Process (NS 222): Competency-Based Course Syllabus.

ERIC Educational Resources Information Center

Brady, Marilyn H.

"Introduction to the Management Process" (NS 222) is an associate degree nursing course offered at Chattanooga State Technical Community College to introduce students to basic management concepts, methods of nursing care delivery, patient classification systems, and methods of enacting change and working as a change agent. Upon completion of the…

A Gentle Introduction to Bayesian Analysis: Applications to Developmental Research

ERIC Educational Resources Information Center

van de Schoot, Rens; Kaplan, David; Denissen, Jaap; Asendorpf, Jens B.; Neyer, Franz J.; van Aken, Marcel A. G.

2014-01-01

Bayesian statistical methods are becoming ever more popular in applied and fundamental research. In this study a gentle introduction to Bayesian analysis is provided. It is shown under what circumstances it is attractive to use Bayesian estimation, and how to interpret properly the results. First, the ingredients underlying Bayesian methods are…

Reference values of amino acids, acylcarnitines and succinylacetone by tandem mass spectrometry for use in newborn screening in southwest Colombia

PubMed Central

Céspedes, Nora; Valencia, Angela; Echeverry, Carlos Alberto; Arce-Plata, Maria Isabel; Colón, Cristóbal; Castiñeiras, Daisy E; Hurtado, Paula Margarita; Cocho, Jose Angel; Herrera, Sócrates

2017-01-01

Abstract Introduction: Inborn errors of metabolism (IEM) represent an important public health problem due to current diagnosis and treatment limitations, poor life quality of affected patients, and consequent untimely child death. In contrast to classical methods, tandem mass spectrometry (MS/MS) has allowed simultaneous evaluation of multiple metabolites associated with IEM offering higher sensitivity, low false positive rates and high throughput. Aims: Determine concentration levels for amino acids and acylcarnitines in blood of newborns from Colombia, to establish reference values for further use in diagnosis of IEM. Methods: Implementation of a method to determine amino acids, acylcarnitines and succinylacetone in newborn dried blood spots using MS/MS, and its application in a cross-sectional study conducted in 891 healthy neonates from Cali and Quibdo cities is described. Results: fifty-seven analytes that allow the diagnosis of more than 40 different pathologies were tested. The method showed to be linear, precise and accurate. Healthy neonates 1-18 days of age were included, 523 from Cali and 368 from Quibdo; 52% male and 48% female. Age-related differences on the concentration levels of amino acids and acylcarnitines were observed whereas no significant differences by gender were found. Conclusion: The study has contributed to reveal the usual concentration levels of amino acids, acylcarnitines and succinylacetone that could be used as reference for the establishment of a newborn metabolic screening program in Colombia. PMID:29213153

Puffed cereals with added chamomile - quantitative analysis of polyphenols and optimization of their extraction method.

PubMed

Blicharski, Tomasz; Oniszczuk, Anna; Olech, Marta; Oniszczuk, Tomasz; Wójtowicz, Agnieszka; Krawczyk, Wojciech; Nowak, Renata

2017-05-11

[b]Abstract Introduction[/b]. Functional food plays an important role in the prevention, management and treatment of chronic diseases. One of the most interesting techniques of functional food production is extrusion-cooking. Functional foods may include such items as puffed cereals, breads and beverages that are fortified with vitamins, some nutraceuticals and herbs. Due to its pharmacological activity, chamomile flowers are the most popular components added to functional food. Quantitative analysis of polyphenolic antioxidants, as well as comparison of various methods for the extraction of phenolic compounds from corn puffed cereals, puffed cereals with an addition of chamomile (3, 5, 10 and 20%) and from [i]Chamomillae anthodium. [/i] [b]Materials and Methods[/b]. Two modern extraction methods - ultrasound assisted extraction (UAE) at 40 °C and 60 °C, as well as accelerated solvent extraction (ASE) at 100 °C and 120 °C were used for the isolation of polyphenols from functional food. Analysis of flavonoids and phenolic acids was carried out using reversed-phase high-performance liquid chromatography and electrospray ionization mass spectrometry (LC-ESI-MS/MS). [b]Results and Conclusions[/b]. For most of the analyzed compounds, the highest yields were obtained by ultrasound assisted extraction. The highest temperature during the ultrasonification process (60 °C) increased the efficiency of extraction, without degradation of polyphenols. UAE easily arrives at extraction equilibrium and therefore permits shorter periods of time, reducing the energy input. Furthermore, UAE meets the requirements of 'Green Chemistry'.

Does charging different user fees for primary and secondary care affect first-contacts with primary healthcare? A systematic review

PubMed Central

Hone, Thomas; Lee, John Tayu; Majeed, Azeem; Conteh, Lesong; Millett, Christopher

2017-01-01

Abstract Policy-makers are increasingly considering charging users different fees between primary and secondary care (differential user charges) to encourage utilisation of primary health care in health systems with limited gate keeping. A systematic review was conducted to evaluate the impact of introducing differential user charges on service utilisation. We reviewed studies published in MEDLINE, EMBASE, the Cochrane library, EconLIT, HMIC, and WHO library databases from January 1990 until June 2015. We extracted data from the studies meeting defined eligibility criteria and assessed study quality using an established checklist. We synthesized evidence narratively. Eight studies from six countries met our eligibility criteria. The overall study quality was low, with diversity in populations, interventions, settings, and methods. Five studies examined the introduction of or increase in user charges for secondary care, with four showing decreased secondary care utilisation, and three showing increased primary care utilisation. One study identified an increase in primary care utilisation after primary care user charges were reduced. The introduction of a non-referral charge in secondary care was associated with lower primary care utilisation in one study. One study compared user charges across insurance plans, associating higher charges in secondary care with higher utilisation in both primary and secondary care. Overall, the impact of introducing differential user-charges on primary care utilisation remains uncertain. Further research is required to understand their impact as a demand side intervention, including implications for health system costs and on utilisation among low-income patients. PMID:28453713

Lessons learnt from human papillomavirus (HPV) vaccination in 45 low- and middle-income countries

PubMed Central

Howard, Natasha; Kabakama, Severin; Mounier-Jack, Sandra; Griffiths, Ulla K.; Feletto, Marta; Burchett, Helen E. D.; LaMontagne, D. Scott; Watson-Jones, Deborah

2017-01-01

Objective To synthesise lessons learnt and determinants of success from human papillomavirus (HPV) vaccine demonstration projects and national programmes in low- and middle-income countries (LAMICs). Methods Interviews were conducted with 56 key informants. A systematic literature review identified 2936 abstracts from five databases; after screening 61 full texts were included. Unpublished literature, including evaluation reports, was solicited from country representatives; 188 documents were received. A data extraction tool and interview topic guide outlining key areas of inquiry were informed by World Health Organization guidelines for new vaccine introduction. Results were synthesised thematically. Results Data were analysed from 12 national programmes and 66 demonstration projects in 46 countries. Among demonstration projects, 30 were supported by the GARDASIL® Access Program, 20 by Gavi, four by PATH and 12 by other means. School-based vaccine delivery supplemented with health facility-based delivery for out-of-school girls attained high coverage. There were limited data on facility-only strategies and little evaluation of strategies to reach out-of-school girls. Early engagement of teachers as partners in social mobilisation, consent, vaccination day coordination, follow-up of non-completers and adverse events was considered invaluable. Micro-planning using school/ facility registers most effectively enumerated target populations; other estimates proved inaccurate, leading to vaccine under- or over-estimation. Refresher training on adverse events and safe injection procedures was usually necessary. Conclusion Considerable experience in HPV vaccine delivery in LAMICs is available. Lessons are generally consistent across countries and dissemination of these could improve HPV vaccine introduction. PMID:28575074

Socioeconomic, hygienic, and sanitation factors in reducing diarrhea in the Amazon

PubMed Central

Imada, Katiuscia Shirota; de Araújo, Thiago Santos; Muniz, Pascoal Torres; de Pádua, Valter Lúcio

2016-01-01

ABSTRACT OBJECTIVE To analyze the contributions of the socioeconomic, hygienic, and sanitation improvements in reducing the prevalence of diarrhea in a city of the Amazon. METHODS In this population-based cross-sectional study, we analyzed data from surveys conducted in the city of Jordão, Acre. In 2005 and 2012, these surveys evaluated, respectively, 466 and 826 children under five years old. Questionnaires were applied on the socioeconomic conditions, construction of houses, food and hygienic habits, and environmental sanitation. We applied Pearson’s Chi-squared test and Poisson regression to verify the relationship between origin of water, construction of homes, age of introduction of cow’s milk in the diet, place of birth and the prevalence of diarrhea. RESULTS The prevalence of diarrhea was reduced from 45.1% to 35.4%. We identified higher probability of diarrhea in children who did not use water from the public network, in those receiving cow’s milk in the first month after birth, and in those living in houses made of paxiúba. Children born at home presented lower risk of diarrhea when compared to those who were born in hospital, with this difference reversing for the 2012 survey. CONCLUSIONS Sanitation conditions improved with the increase of bathrooms with toilets, implementation of the Programa de Saúde da Família (PSF – Family Health Program), and water treatment in the city. The multivariate regression model identified a statistically significant association between use of water from the public network, construction of houses, late introduction of cow’s milk, and access to health service with occurrence of diarrhea. PMID:28099660

A New Method for Post-introduction Risk Assessment of Biological Invasions Among Introduced Shrubs in Developing Countries.

PubMed

Seburanga, J L; Bizuru, E; Mwavu, E N; Kampungu, K G; Gatesire, T; Kaplin, B A

2016-03-01

Risk-assessment methods are useful in collecting data that can help decision making to prevent the introduction of new species that have the potential of invading as well as in management of established taxa. Not only the complexity and unaffordability of available pre-introduction risk-assessment models make them rarely or inconsistently applied in the least-developed countries, but also there is lack of tools to assess the status of already introduced plant species. In this study, an affordable and rapid method of assessment of invasiveness among introduced plant species was developed and tested in Rwanda. This method defines three invasion stages (potential, effective, and suppressive invaders) and four levels of risk assessment: post-introduction assessment of species inherent invasive potential (Level 1), post-establishment assessment of species capacity of regeneration (Level 2), post-naturalization assessment of species range of occurrence and ability for long-distance dispersal (Level 3), and post-naturalization assessment of species ability to outcompete other plants in the community and transform the landscape (Level 4). A review of invasive species in Rwanda was developed through desk review, examination of herbarium records, and vegetation surveys. This method should be applicable in other countries that lack the means for a more conventional scientific investigation or under any circumstance where a quick and inexpensive assessment is needed. The method could be useful to environmental managers for timely intervention with strategies specific to different stages of invasion (post-introduction, post-establishment, or post-naturalization) and allocate resources accordingly.

A New Method for Post-introduction Risk Assessment of Biological Invasions Among Introduced Shrubs in Developing Countries

NASA Astrophysics Data System (ADS)

Seburanga, J. L.; Bizuru, E.; Mwavu, E. N.; Kampungu, K. G.; Gatesire, T.; Kaplin, B. A.

2016-03-01

Risk-assessment methods are useful in collecting data that can help decision making to prevent the introduction of new species that have the potential of invading as well as in management of established taxa. Not only the complexity and unaffordability of available pre-introduction risk-assessment models make them rarely or inconsistently applied in the least-developed countries, but also there is lack of tools to assess the status of already introduced plant species. In this study, an affordable and rapid method of assessment of invasiveness among introduced plant species was developed and tested in Rwanda. This method defines three invasion stages (potential, effective, and suppressive invaders) and four levels of risk assessment: post-introduction assessment of species inherent invasive potential ( Level 1), post-establishment assessment of species capacity of regeneration ( Level 2), post-naturalization assessment of species range of occurrence and ability for long-distance dispersal ( Level 3), and post-naturalization assessment of species ability to outcompete other plants in the community and transform the landscape ( Level 4). A review of invasive species in Rwanda was developed through desk review, examination of herbarium records, and vegetation surveys. This method should be applicable in other countries that lack the means for a more conventional scientific investigation or under any circumstance where a quick and inexpensive assessment is needed. The method could be useful to environmental managers for timely intervention with strategies specific to different stages of invasion (post-introduction, post-establishment, or post-naturalization) and allocate resources accordingly.

Benefits and Limitations of DNA Barcoding and Metabarcoding in Herbal Product Authentication

PubMed Central

Raclariu, Ancuta Cristina; Heinrich, Michael; Ichim, Mihael Cristin

2017-01-01

Abstract Introduction Herbal medicines play an important role globally in the health care sector and in industrialised countries they are often considered as an alternative to mono‐substance medicines. Current quality and authentication assessment methods rely mainly on morphology and analytical phytochemistry‐based methods detailed in pharmacopoeias. Herbal products however are often highly processed with numerous ingredients, and even if these analytical methods are accurate for quality control of specific lead or marker compounds, they are of limited suitability for the authentication of biological ingredients. Objective To review the benefits and limitations of DNA barcoding and metabarcoding in complementing current herbal product authentication. Method Recent literature relating to DNA based authentication of medicinal plants, herbal medicines and products are summarised to provide a basic understanding of how DNA barcoding and metabarcoding can be applied to this field. Results Different methods of quality control and authentication have varying resolution and usefulness along the value chain of these products. DNA barcoding can be used for authenticating products based on single herbal ingredients and DNA metabarcoding for assessment of species diversity in processed products, and both methods should be used in combination with appropriate hyphenated chemical methods for quality control. Conclusions DNA barcoding and metabarcoding have potential in the context of quality control of both well and poorly regulated supply systems. Standardisation of protocols for DNA barcoding and DNA sequence‐based identification are necessary before DNA‐based biological methods can be implemented as routine analytical approaches and approved by the competent authorities for use in regulated procedures. © 2017 The Authors. Phytochemical Analysis Published by John Wiley & Sons Ltd. PMID:28906059

Knowledge acquisition for temporal abstraction.

PubMed

Stein, A; Musen, M A; Shahar, Y

1996-01-01

Temporal abstraction is the task of detecting relevant patterns in data over time. The knowledge-based temporal-abstraction method uses knowledge about a clinical domain's contexts, external events, and parameters to create meaningful interval-based abstractions from raw time-stamped clinical data. In this paper, we describe the acquisition and maintenance of domain-specific temporal-abstraction knowledge. Using the PROTEGE-II framework, we have designed a graphical tool for acquiring temporal knowledge directly from expert physicians, maintaining the knowledge in a sharable form, and converting the knowledge into a suitable format for use by an appropriate problem-solving method. In initial tests, the tool offered significant gains in our ability to rapidly acquire temporal knowledge and to use that knowledge to perform automated temporal reasoning.

What do reviewers look for in an original research article?

PubMed

Shankar, P R

2012-01-01

In this article common errors committed by authors especially those, whose first language is not English, while writing an original research articleis described. Avoiding common errors and improving chances of publication has also been covered. This article may resemble instruction to the author. However, tips from reviewer's eyes has been given. The abstract is the section of the paper most commonly read and care should be taken while writing this section. Keywordsare usedto retrieve articles following searches and use of words from the MeSH database is recommended.The introduction describes work already conducted in the particular area and briefly mentions how the manuscript will add to the existing knowledge.The methods section describes how the study was conducted, is written in the past tense and is often the first part of the paper to be written. The results describe what was found in the study and is usually written after the methods section.The discussion compares the study with the literature and helps to put the study findings in context. The conclusions should be based on the results of the study. The references should be written strictly according to the journal format. Language should be simple, active voice should be used and jargon avoided. Avoid directly quoting from reference articles and paraphrase these in your own words to avoid plagiarism.

Telemetric Detection of Chronic Obstructive Pulmonary Disease and Investigation of Quality of Life for People Working in Shipbuilding Industry

PubMed Central

Koulouri, Agoritsa; Gourgoulianis, Konstantinos; Hatzoglou, Chryssi; Roupa, Zoe

2014-01-01

ABSTRACT Introduction: Chronic Obstructive Pulmonary Disease (COPD) has a significant impact on quality of life-related health. Aim: It was the detection of Chronic Obstructive Pulmonary Disease by using telemetric methods and the investigation of the quality of life for people working in Shipbuilding Industry compared with a control group. Methods: A group of one hundred men working in the shipbuilding industry aged 51.8 ± 8.2 years old and a control group of one hundred men of the general population aged 51.1 ± 6.4 years were studied. All participants completed the General Health Questionnaire – 28, the Fagerstrom test and a form with demographic characteristics. Pulmonary function test results were electronically sent to a specialist for evaluation. Results: People working in the shipbuilding zone had significantly lower values (p<0.001) in FVC, FEV1 and FEV1/FVC compared with the general population participants. Worse social functionality was exhibited by workers in the shipbuilding zone, people with elementary education, unemployed and by those suffering from comorbidities (p <0.001). Conclusions: Health level and its individual dimensions are both associated with health self-assessment and occupational and economic status. The coexistence of chronic diseases and smoking dependence affects emotion and social functioning of individuals. PMID:25568580

Evaluation and optimization of microbial DNA extraction from fecal samples of wild Antarctic bird species

PubMed Central

Eriksson, Per; Mourkas, Evangelos; González-Acuna, Daniel; Olsen, Björn; Ellström, Patrik

2017-01-01

ABSTRACT Introduction: Advances in the development of nucleic acid-based methods have dramatically facilitated studies of host–microbial interactions. Fecal DNA analysis can provide information about the host’s microbiota and gastrointestinal pathogen burden. Numerous studies have been conducted in mammals, yet birds are less well studied. Avian fecal DNA extraction has proved challenging, partly due to the mixture of fecal and urinary excretions and the deficiency of optimized protocols. This study presents an evaluation of the performance in avian fecal DNA extraction of six commercial kits from different bird species, focusing on penguins. Material and methods: Six DNA extraction kits were first tested according to the manufacturers’ instructions using mallard feces. The kit giving the highest DNA yield was selected for further optimization and evaluation using Antarctic bird feces. Results: Penguin feces constitute a challenging sample type: most of the DNA extraction kits failed to yield acceptable amounts of DNA. The QIAamp cador Pathogen kit (Qiagen) performed the best in the initial investigation. Further optimization of the protocol resulted in good yields of high-quality DNA from seven bird species of different avian orders. Conclusion: This study presents an optimized approach to DNA extraction from challenging avian fecal samples. PMID:29152162

Impact of HIV-related stigma on treatment adherence: systematic review and meta-synthesis

PubMed Central

Katz, Ingrid T; Ryu, Annemarie E; Onuegbu, Afiachukwu G; Psaros, Christina; Weiser, Sheri D; Bangsberg, David R; Tsai, Alexander C

2013-01-01

Introduction Adherence to HIV antiretroviral therapy (ART) is a critical determinant of HIV-1 RNA viral suppression and health outcomes. It is generally accepted that HIV-related stigma is correlated with factors that may undermine ART adherence, but its relationship with ART adherence itself is not well established. We therefore undertook this review to systematically assess the relationship between HIV-related stigma and ART adherence. Methods We searched nine electronic databases for published and unpublished literature, with no language restrictions. First we screened the titles and abstracts for studies that potentially contained data on ART adherence. Then we reviewed the full text of these studies to identify articles that reported data on the relationship between ART adherence and either HIV-related stigma or serostatus disclosure. We used the method of meta-synthesis to summarize the findings from the qualitative studies. Results Our search protocol yielded 14,854 initial records. After eliminating duplicates and screening the titles and abstracts, we retrieved the full text of 960 journal articles, dissertations and unpublished conference abstracts for review. We included 75 studies conducted among 26,715 HIV-positive persons living in 32 countries worldwide, with less representation of work from Eastern Europe and Central Asia. Among the 34 qualitative studies, our meta-synthesis identified five distinct third-order labels through an inductive process that we categorized as themes and organized in a conceptual model spanning intrapersonal, interpersonal and structural levels. HIV-related stigma undermined ART adherence by compromising general psychological processes, such as adaptive coping and social support. We also identified psychological processes specific to HIV-positive persons driven by predominant stigmatizing attitudes and which undermined adherence, such as internalized stigma and concealment. Adaptive coping and social support were critical determinants of participants’ ability to overcome the structural and economic barriers associated with poverty in order to successfully adhere to ART. Among the 41 quantitative studies, 24 of 33 cross-sectional studies (71%) reported a positive finding between HIV stigma and ART non-adherence, while 6 of 7 longitudinal studies (86%) reported a null finding (Pearson's χ 2=7.7; p=0.005). Conclusions We found that HIV-related stigma compromised participants’ abilities to successfully adhere to ART. Interventions to reduce stigma should target multiple levels of influence (intrapersonal, interpersonal and structural) in order to have maximum effectiveness on improving ART adherence. PMID:24242258

Emerging Patterns of Abstraction in Environmental Education: A Review of Materials, Methods and Professional Development Perspectives

ERIC Educational Resources Information Center

O'Donoghue, Rob; Russo, Vladimir

2004-01-01

This paper examines how emerging materials and associated methods became inscribed within and have shaped developing patterns of practice in environmental education. In so doing, it gives attention to how materials and methods have informed methodological narratives and shaped abstracted propositions used in professional development activities.…

Promoting Students' Self-Directed Learning Ability through Teaching Mathematics for Social Justice

ERIC Educational Resources Information Center

Voss, Richard; Rickards, Tony

2016-01-01

Mathematics is a subject which is often taught using abstract methods and processes. These methods by their very nature may for students alienate the relationship between Mathematics and real life situations. Further, these abstract methods and processes may disenfranchise students from becoming self-directed learners of Mathematics. A solution to…

An Introduction of Finite Element Method in the Engineering Teaching at the University of Camaguey.

ERIC Educational Resources Information Center

Napoles, Elsa; Blanco, Ramon; Jimenez, Rafael; Mc.Pherson, Yoanka

This paper illuminates experiences related to introducing finite element methods (FEM) in mechanical and civil engineering courses at the University of Camaguey in Cuba and provides discussion on using FEM in postgraduate courses for industry engineers. Background information on the introduction of FEM in engineering teaching is focused on…

A SYSTEMATIC REVIEW OF THE LITERATURE CONCERNING THE RELATIONSHIP BETWEEN OBESITY AND MORTALITY IN THE ELDERLY

PubMed Central

DONINI, L. M.; SAVINA, C.; GENNARO, E.; DE FELICE, M. R.; ROSANO, A.; PANDOLFO, M. M.; BALZO, V. DEL; CANNELLA, C.; RITZ, P.; CHUMLEA, WM. C.

2014-01-01

Introduction Obesity is a risk factor for chronic diseases and premature mortality, but the extent of these associations among the elderly is under debate. The aim of this systematic literature review (SR) is to collate and critically assess the available information of the impact of obesity on mortality in the elderly. Methods In PubMed, there are three-hundred twelve papers on the relationship between obesity and mortality among older adults. These papers were analysed on the basis of their abstracts, and sixteen studies were considered suitable for the purpose of the study. It was possible to perform a pooled estimate for aggregated data in three different studies. Conclusion The results of this SR document that an increased mortality in obese older adults. The limitation of BMI to index obesity and the noted protective action of a moderate increase in BMI on mortality are highlighted. Waist circumference is an indicator of central adiposity and potentially as good a risk factor for mortality as BMI in obese elderly adults. PMID:22238007

A systematic review of the factors that influence the quality and effectiveness of telesupervision for health professionals.

PubMed

Martin, Priya; Lizarondo, Lucylynn; Kumar, Saravana

2018-05-01

Introduction Whilst telesupervision (clinical supervision undertaken using communication technology) is being used more frequently, there is limited information on what factors influence its effectiveness and quality. We undertook this systematic review to address this gap. Methods Eligible telesupervision studies were identified following targeted search of electronic databases and the grey literature. Data were synthesised thematically, resulting in development of core themes. Results We identified 286 papers for initial relevancy screening by title and abstract. The full text of 36 papers were then retrieved and assessed for further relevance. A total of 11 papers were included in the final analysis. We identified eight themes that contribute to effective and high-quality telesupervision: supervisee characteristics, supervisor characteristics, supervision characteristics, supervisory relationship, communication strategies, prior face-to-face contact, environmental factors and technological considerations. Conclusion From the available evidence, telesupervision can be a feasible and acceptable form of clinical supervision if set up well. Further studies with robust designs are required to strengthen the existing evidence on what makes telesupervision effective, as well as to examine its cost-effectiveness.

Design and Implementation of a Set-Top Box–Based Homecare System Using Hybrid Cloud

PubMed Central

Lin, Bor-Shing; Hsiao, Pei-Chi; Cheng, Po-Hsun; Jan, Gene Eu

2015-01-01

Abstract Introduction: Telemedicine has become a prevalent topic in recent years, and several telemedicine systems have been proposed; however, such systems are an unsuitable fit for the daily requirements of users. Materials and Methods: The system proposed in this study was developed as a set-top box integrated with the Android™ (Google, Mountain View, CA) operating system to provide a convenient and user-friendly interface. The proposed system can assist with family healthcare management, telemedicine service delivery, and information exchange among hospitals. To manage the system, a novel type of hybrid cloud architecture was also developed. Results: Updated information is stored on a public cloud, enabling medical staff members to rapidly access information when diagnosing patients. In the long term, the stored data can be reduced to improve the efficiency of the database. Conclusions: The proposed design offers a robust architecture for storing data in a homecare system and can thus resolve network overload and congestion resulting from accumulating data, which are inherent problems in centralized architectures, thereby improving system efficiency. PMID:26075333

One Year Outcomes of Tension-Free Vaginal Tape (TVT) Mid-Urethral Slings in Overweight and Obese Women

PubMed Central

Killingsworth, Lindsay B.; Wheeler, Thomas L.; Burgio, Kathryn L.; Martirosian, Tovia E.; Redden, David T.; Richter, Holly E.

2011-01-01

Introduction The purpose of this study was to assess the impact of body mass index (BMI) on tension-free vaginal tape (TVT) success rates, patient satisfaction, and complications one year following surgery. Methods Baseline and one-year post-surgery outcomes were abstracted, including Urogenital Distress Inventory (UDI-6) scores, Incontinence Impact Questionnaire (IIQ-7) scores, and patient satisfaction ratings. Multivariable logistic and linear regression analyses were performed to examine relationships between outcomes and BMI. Results 195 subjects with a mean age of 59.3 ±12.6 were included. There was significant improvement within each group (all p-values <0.01) in total UDI-6 and IIQ-7 scores from baseline to one year post-surgery; all groups had high patient satisfaction. No differences in improvement or complications rates were observed among the BMI cohorts (all p-values >0.05) Conclusion Differential counseling of overweight or obese women regarding outcomes of the TVT procedure is not supported by these results; longer follow-up is warranted. PMID:19448965

Effect of Cell Phone Radiations on Orofacial Structures: A Systematic Review

PubMed Central

Chowdhary, Ramesh; Kumari, Shail; Rao, Srinivasa B

2017-01-01

Introduction: The widespread use of cell phone in recent years has raised many questions whether their use is safe to operator who is exposed to Electromagnetic Waves (EMV). Aim To find out the effect of cell phone emitted radiations on the orofacial structures. Materials and Methods To identify suitable literature, an electronic search was performed using Medline, Pubmed and EBSCO host database in December 2016. The search was focused on effect of cell phone on orofacial structures. Among the literature available in English, the screening of the related titles and abstracts was done, and only those articles were selected for full text reading that fulfilled the inclusion criteria. Results The initial literature search resulted in 360 articles out of which only 24 articles fulfilled the inclusion criteria and were included in this systematic review. Conclusion Cell phone emitted radiations had their adverse effect on salivary glands and facial nerves. Studies showed that cell phone emitted radiations had effects on oral mucosal cells and causes changes in salivary flow rate. It was still unclear that cell phone radiations cause tumours of the salivary glands. PMID:28658925

Chronic pain has a strong impact on quality of life in facioscapulohumeral muscular dystrophy

PubMed Central

Wood, Libby; FernáNdez‐Torrón, Roberto; González Coraspe, José Andrés; Turner, Chris; Hilton‐Jones, David; Norwood, Fiona; Willis, Tracey; Parton, Matt; Rogers, Mark; Hammans, Simon; Roberts, Mark; Househam, Elizabeth; Williams, Maggie; Lochmüller, Hanns; Evangelista, Teresinha

2017-01-01

ABSTRACT Introduction Earlier small case series and clinical observations reported on chronic pain playing an important role in facioscapulohumeral dystrophy (FSHD). The aim of this study was to determine the characteristics and impact of pain on quality of life (QoL) in patients with FSHD. Methods We analyzed patient reported outcome measures collected through the U.K. FSHD Patient Registry. Results Of 398 patients, 88.6% reported pain at the time of study. The most frequent locations were shoulders and lower back. A total of 203 participants reported chronic pain, 30.4% of them as severe. The overall disease impact on QoL was significantly higher in patients with early onset and long disease duration. Chronic pain had a negative impact on all Individualised Neuromuscular Quality of Life Questionnaire domains and overall disease score. Discussion Our study shows that pain in FSHD type 1 (FSHD1) is frequent and strongly impacts on QoL, similar to other chronic, painful disorders. Management of pain should be considered when treating FSHD1 patients. Muscle Nerve 57: 380–387, 2018 PMID:29053898

Class II malocclusion with accentuated occlusal plane inclination corrected with miniplate: a case report

PubMed Central

Farret, Marcel Marchiori; Farret, Milton M. Benitez

2016-01-01

ABSTRACT Introduction: A canted occlusal plane presents an unesthetic element of the smile. The correction of this asymmetry has been typically considered difficult by orthodontists, as it requires complex mechanics and may sometimes even require orthognathic surgery. Objective: This paper outlines the case of a 29-year-old woman with Class II malocclusion, pronounced midline deviation and accentuated occlusal plane inclination caused by mandibular deciduous molar ankylosis. Methods: The patient was treated with a miniplate used to provide anchorage in order to intrude maxillary teeth and extrude mandibular teeth on one side, thus eliminating asymmetry. Class II was corrected on the left side by means of distalization, anchored in the miniplate as well. On the right side, maxillary first premolar was extracted and molar relationship was kept in Class II, while canines were moved to Class I relationship. The patient received implant-prosthetic rehabilitation for maxillary left lateral incisor and mandibular left second premolar. Results: At the end of treatment, Class II was corrected, midlines were matched and the canted occlusal plane was totally corrected, thereby improving smile function and esthetics. PMID:27409658

Process Improvement for Interinstitutional Research Contracting

PubMed Central

Logan, Jennifer; Bjorklund, Todd; Whitfield, Jesse; Reed, Peggy; Lesher, Laurie; Sikalis, Amy; Brown, Brent; Drollinger, Sandy; Larrabee, Kristine; Thompson, Kristie; Clark, Erin; Workman, Michael; Boi, Luca

2015-01-01

Abstract Introduction Sponsored research increasingly requires multiinstitutional collaboration. However, research contracting procedures have become more complicated and time consuming. The perinatal research units of two colocated healthcare systems sought to improve their research contracting processes. Methods The Lean Process, a management practice that iteratively involves team members in root cause analyses and process improvement, was applied to the research contracting process, initially using Process Mapping and then developing Problem Solving Reports. Results Root cause analyses revealed that the longest delays were the individual contract legal negotiations. In addition, the “business entity” was the research support personnel of both healthcare systems whose “customers” were investigators attempting to conduct interinstitutional research. Development of mutually acceptable research contract templates and language, chain of custody templates, and process development and refinement formats decreased the Notice of Grant Award to Purchase Order time from a mean of 103.5 days in the year prior to Lean Process implementation to 45.8 days in the year after implementation (p = 0.004). Conclusions The Lean Process can be applied to interinstitutional research contracting with significant improvement in contract implementation. PMID:26083433

Diagnostic confounders of chronic widespread pain: not always fibromyalgia

PubMed Central

Häuser, Winfried; Perrot, Serge; Sommer, Claudia; Shir, Yoram; Fitzcharles, Mary-Ann

2017-01-01

Abstract Introduction: Chronic widespread pain (CWP) is the defining feature of fibromyalgia (FM), a worldwide prevalent condition. Chronic widespread pain is, however, not pathognomonic of FM, and other conditions may present similarly with CWP, requiring consideration of a differential diagnosis. Objectives: To conduct a literature search to identify medical conditions that may mimic FM and have highlighted features that may differentiate these various conditions from FM. Methods: A comprehensive literature search from 1990 through September 2016 was conducted to identify conditions characterized by CWP. Results: Conditions that may mimic FM may be categorized as musculoskeletal, neurological, endocrine/metabolic, psychiatric/psychological, and medication related. Characteristics pertaining to the most commonly identified confounding diagnoses within each category are discussed; clues to enable clinical differentiation from FM are presented; and steps towards a diagnostic algorithm for mimicking conditions are presented. Conclusion: Although the most likely reason for a complaint of CWP is FM, this pain complaint can be a harbinger of illness other than FM, prompting consideration of a differential diagnosis. This review should sensitize physicians to a broad spectrum of conditions that can mimic FM. PMID:29392213

Clinical relevance of cytogenetics to pediatric practice. Postnatal findings of Patau syndrome – Review of 5 cases

PubMed Central

PLAIASU, Vasilica; OCHIANA, Diana; MOTEI, Gabriela; ANCA, Ioana; GEORGESCU, Adrian

2010-01-01

ABSTRACT Introduction: Patau syndrome (trisomy 13) is one of the most common chromosomal anomalies clinically characterized by the presence of numerous malformations with a limited survival rate for most cases. Babies are usually identified at birth and the diagnosis is confirmed with genetic testing. Materials and methods: In this review we outline the clinical and cytogenetic aspects of trisomy 13 and associated phenotypes for 5 cases analyzed in the last 3 years, referred to our Clinical Genetics Department. For each child cytogenetic analysis was performed to determine the genetic variant; also, the patients were investigated for other associated malformations (cardiac, cerebral, renal, ocular anomalies). Discussion: All 5 cases presented multiple malformations, including some but not all signs of the classical clinical triad suggestive of Patau syndrome. The cytogenetic investigation confirmed for each case the suspected diagnosis and also indicated the specific genetic variant, this being a valuable information for the genetic counselling of the families. Conclusion: The application of genetic analysis can increase diagnosis and prognosis accuracy and have an impact on clinical management. PMID:21977150

Assessment of intensive care unit‐acquired weakness in young and old mice: An E. coli septic peritonitis model

PubMed Central

Hoogland, Inge C.M.; Wieske, Luuk; Weber, Nina C.; Verhamme, Camiel; Schultz, Marcus J.; van Schaik, Ivo N.; Horn, Janneke

2015-01-01

ABSTRACT Introduction: There are few reports of in vivo muscle strength measurements in animal models of ICU‐acquired weakness (ICU‐AW). In this study we investigated whether the Escherichia coli (E. coli) septic peritonitis mouse model may serve as an ICU‐AW model using in vivo strength measurements and myosin/actin assays, and whether development of ICU‐AW is age‐dependent in this model. Methods: Young and old mice were injected intraperitoneally with E. coli and treated with ceftriaxone. Forelimb grip strength was measured at multiple time points, and the myosin/actin ratio in muscle was determined. Results: E. coli administration was not associated with grip strength decrease, neither in young nor in old mice. In old mice, the myosin/actin ratio was lower in E. coli mice at t = 48 h and higher at t = 72 h compared with controls. Conclusions: This E. coli septic peritonitis mouse model did not induce decreased grip strength. In its current form, it seems unsuitable as a model for ICU‐AW. Muscle Nerve 53: 127–133, 2016 PMID:26015329

Considerations for the Use of Human Participants in Vector Biology Research: A Tool for Investigators and Regulators

PubMed Central

Youngblood, Laura; Bangs, Michael J.; Lavery, James V.; James, Stephanie

2015-01-01

Abstract A thorough search of the existing literature has revealed that there are currently no published recommendations or guidelines for the interpretation of US regulations on the use of human participants in vector biology research (VBR). An informal survey of vector biologists has indicated that issues related to human participation in vector research have been largely debated by academic, national, and local Institutional Review Boards (IRBs) in the countries where the research is being conducted, and that interpretations and subsequent requirements made by these IRBs have varied widely. This document is intended to provide investigators and corresponding scientific and ethical review committee members an introduction to VBR methods involving human participation and the legal and ethical framework in which such studies are conducted with a focus on US Federal Regulations. It is also intended to provide a common perspective for guiding researchers, IRB members, and other interested parties (i.e., public health officials conducting routine entomological surveillance) in the interpretation of human subjects regulations pertaining to VBR. PMID:25700039

Incorporating Behavioral Techniques into a Serious Videogame for Children

PubMed Central

2017-01-01

Abstract Introduction: Little is known about how to design serious videogames for children. The purpose of this article is to describe how behavior change techniques promoting self-regulation were incorporated into a serious videogame to help children consume more fruits and vegetables (FVs) and the extent to which these techniques were used by players. A secondary goal is to contribute to the body of scientific knowledge regarding how to design effective serious videogames for children. Materials and Methods: This research examines the gameplay data from an effective 10-episode online serious videogame promoting FV consumption to preadolescent children in the United States (roughly 9–11-year-olds). Results: Children participated in the self-regulation components. Modifications to reduce potential cognitive overload and inform future game design were identified. Conclusion: This research provided suggestive evidence that behavior change techniques promoting self-regulation can be successfully integrated into a serious videogame for children without detracting from game appeal. It also emphasizes the importance of formative research to the design of an appealing game where children understand and can successfully perform the behavior change procedures. PMID:28231024

Cryptococcal cerebellitis in no-VIH patient

PubMed Central

Zamora Bastidas, Tomas Omar; Potosí García, Jorge Andrés; Díaz Idrobo, Bairon

2017-01-01

Abstract Introduction: Cryptococcosis is an opportunistic fungal infection whose etiology is Cryptococcus neofromans / C. gattii, complex which affects immunocompromised patients mainly. Meningeal infection is one of the most common presentations, but cerebellar affection is rare. Case Description: Male patient with 65 old years, from an area of subtropical climate with chronic exposure to poultry, without pathological antecedents, who presented clinical picture consistent with headache, fever, seizures and altered mental status. Clinical findings and diagnostic methods: Initially without menigeal signs or intracranial hypertension and normal neurological examination. Later, the patient developed ataxia, dysdiadochokinesia and limb loss. By lumbar punction and image of nuclear magnetic resonance (NMR) cerebellitis cryptococcal was diagnosticated. Treatment: Antifungal therapy with amphotericin B and fluconazole was performed, however the patient died. Clinical Relevance: The cryptococcosis has different presentations, it´s a disease whose incidence has been increasing since the advent of the HIV / AIDS pandemy, however the commitment of the encephalic parenchyma and in particular the cerebellum is considered rare. In this way we are facing the first case of cryptococcal cerebellitis in our midst. PMID:29021643

Weak signal detection: A discrete window of opportunity for achieving ‘Vision 90:90:90’?

PubMed Central

Burman, Christopher J.; Aphane, Marota; Delobelle, Peter

2016-01-01

Abstract Introduction: UNAIDS’ Vision 90:90:90 is a call to ‘end AIDS’. Developing predictive foresight of the unpredictable changes that this journey will entail could contribute to the ambition of ‘ending AIDS’. There are few opportunities for managing unpredictable changes. We introduce ‘weak signal detection’ as a potential opportunity to fill this void. Method: Combining futures and complexity theory, we reflect on two pilot case studies that involved the Archetype Extraction technique and the SenseMaker® Collector™ tool. Results: Both the piloted techniques have the potentials to surface weak signals – but there is room for improvement. Discussion: A management response to a complex weak signal requires pattern management, rather than an exclusive focus on behaviour management. Conclusion: Weak signal detection is a window of opportunity to improve resilience to unpredictable changes in the HIV/AIDS landscape that can both reduce the risk that emerges from the changes and increase the visibility of opportunities to exploit the unpredictable changes that could contribute to ‘ending AIDS’. PMID:26821952

Influence of protein fold stability on immunogenicity and its implications for vaccine design

PubMed Central

Scheiblhofer, Sandra; Laimer, Josef; Machado, Yoan; Weiss, Richard; Thalhamer, Josef

2017-01-01

ABSTRACT Introduction: In modern vaccinology and immunotherapy, recombinant proteins more and more replace whole organisms to induce protective or curative immune responses. Structural stability of proteins is of crucial importance for efficient presentation of antigenic peptides on MHC, which plays a decisive role for triggering strong immune reactions. Areas covered: In this review, we discuss structural stability as a key factor for modulating the potency of recombinant vaccines and its importance for antigen proteolysis, presentation, and stimulation of B and T cells. Moreover, the impact of fold stability on downstream events determining the differentiation of T cells into effector cells is reviewed. We summarize studies investigating the impact of protein fold stability on the outcome of the immune response and provide an overview on computational methods to estimate the effects of point mutations on protein stability. Expert commentary: Based on this information, the rational design of up-to-date vaccines is discussed. A model for predicting immunogenicity of proteins based on their conformational stability at different pH values is proposed. PMID:28290225

THE IMPACT OF THE MELD SCORE ON LIVER TRANSPLANT ALLOCATION AND RESULTS: AN INTEGRATIVE REVIEW

PubMed Central

de MORAES, Ana Claudia Oliveira; de OLIVEIRA, Priscilla Caroliny; da FONSECA-NETO, Olival Cirilo Lucena

2017-01-01

ABSTRACT Introduction: Liver transplantation is intended to increase the survival of patients with chronic liver disease in terminal phase, as well as improved quality of life. Since the first transplant until today many changes have occurred in the organ allocation system. Objective: To review the literature on the Model for End-stage Liver Disease (MELD) and analyze its correlation with survival after liver transplantation. Method: An integrative literature review in Lilacs, SciELO, and Pubmed in October 2015, was realized. Were included eight studies related to the MELD score and its impact on liver transplant. Results: There was predominance of transplants in male between 45-55 y. The main indications were hepatitis C, hepatocellular carcinoma and alcoholic cirrhosis. The most important factors post-surgery were related to the MELD score, the recipient age, expanded donor criteria and hemotransfusion. Conclusion: The MELD system reduced the death rate in patients waiting for a liver transplant. However, this score by itself is not a good predictor of survival after liver transplantation. PMID:28489174

The Effectiveness of Telemental Health: A 2013 Review

PubMed Central

Ferrer, Daphne C.; Parish, Michelle Burke; Johnston, Barb; Callahan, Edward J.; Yellowlees, Peter M.

2013-01-01

Abstract Introduction: The effectiveness of any new technology is typically measured in order to determine whether it successfully achieves equal or superior objectives over what is currently offered. Research in telemental health—in this article mainly referring to telepsychiatry and psychological services—has advanced rapidly since 2003, and a new effectiveness review is needed. Materials and Methods: The authors reviewed the published literature to synthesize information on what is and what is not effective related to telemental health. Terms for the search included, but were not limited to, telepsychiatry, effectiveness, mental health, e-health, videoconferencing, telemedicine, cost, access, and international. Results: Telemental health is effective for diagnosis and assessment across many populations (adult, child, geriatric, and ethnic) and for disorders in many settings (emergency, home health) and appears to be comparable to in-person care. In addition, this review has identified new models of care (i.e., collaborative care, asynchronous, mobile) with equally positive outcomes. Conclusions: Telemental health is effective and increases access to care. Future directions suggest the need for more research on service models, specific disorders, the issues relevant to culture and language, and cost. PMID:23697504

A survey of cavity-nesting bees and wasps in loblolly pine stands of the Savannah River Site, Aiken County, South Carolina.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Horn, S.; Hanula, J., L.

2004-03-10

Horn, Scott, and James L. Hanula. 2004. A survey of cavity-nesting bees and wasps in loblolly pine stands of the Savannah River Site, Aiken County, South Carolina. 39(3): 464-469. Abstract: In recent years concern over widespread losses in biodiversity has grown to include a possible decline of many native pollinators, primarily bees. Factors such as habitat fragmentation, agricultural practices, use of pesticides, the introduction of invasive species, or changes in land use may negatively impact these vital organisims. Most reported studies show that human impacts on pollinators are overwhelmingly negative. Reductions in pollinator populations may profoundly impact plant population dynamicsmore » and ecosystem function. Little baseline data exists on the diversity and relative abundance of bees and wasps in southern forests. The objective of this study was to develop a simple, effective method of surveying cavity-nesting bees and wasps and to determine species diversity in mature forests of loblolly pine, the most widely planted tree species in the southern United States.« less

Sleep and executive functions in older adults: A systematic review

PubMed Central

Holanda, Francisco Wilson Nogueira; de Almondes, Katie Moraes

2016-01-01

ABSTRACT Introduction: A recent increase in studies suggests a role of age-related sleep changes in executive functions (EF). However, this relationship remains unclear and mixed results have emerged. Objective: To investigate how age-related sleep changes may play an important role in the extent to which healthy older adults exhibit decline in EF. Methods: A systematic strategy was employed to identify the available literature on age-related sleep changes and EF. Results: Of the 465 studies identified, 26 were included. Results suggest that multiple sleep parameters differ in the way they benefit or impair EF. Parameters such as greater wake after sleep onset and lower sleep efficiency, in addition to circadian fragmentation of sleep, showed more consistent results and are potentially correlated with worsening in EF measures. However, other results seem inconclusive. Conclusion: These findings were discussed based on the prefrontal circuitry vulnerability model, in which sleep has been identified as a beneficial factor for prefrontal cortex functioning and hence for EF, which relies mostly on this brain area and its related networks. PMID:29213454

Mobile health solutions for the aging population: A systematic narrative analysis.

PubMed

Kruse, Clemens Scott; Mileski, Michael; Moreno, Joshua

2017-05-01

Introduction The ubiquitous nature of mobile technology coupled with the acceptance of mobile health (mHealth) among the elderly offers an opportunity to augment the existing medical workforce in long-term care. The objective of this review and narrative analysis is to identify and analyse facilitators and barriers to adoption of mHealth for the elderly. Methods Studies over the last year were identified in multiple database indices, and three reviewers examined abstracts ( k = 0.82) and analysed articles for themes which were tallied in affinity diagrams to identify frequency of occurrence in the literature (n = 36). Results The three facilitators mentioned most often were independence (18%), understanding (13%), and visibility (13%). The three barriers mentioned most often were complexity (21%), limited by users (12%) and ineffective (12%). Discussion and conclusions The reviewers concluded that the work done so far illustrates that mHealth enables a perception of independence. Future research should focus on the barriers of complexity of technology and improving existing medical literacy in order to facilitate further adoption.

A structured approach to recording AIDS-defining illnesses in Kenya: A SNOMED CT based solution

PubMed Central

Oluoch, Tom; de Keizer, Nicolette; Langat, Patrick; Alaska, Irene; Ochieng, Kenneth; Okeyo, Nicky; Kwaro, Daniel; Cornet, Ronald

2016-01-01

Introduction Several studies conducted in sub-Saharan Africa (SSA) have shown that routine clinical data in HIV clinics often have errors. Lack of structured and coded documentation of diagnosis of AIDS defining illnesses (ADIs) can compromise data quality and decisions made on clinical care. Methods We used a structured framework to derive a reference set of concepts and terms used to describe ADIs. The four sources used were: (i) CDC/Accenture list of opportunistic infections, (ii) SNOMED Clinical Terms (SNOMED CT), (iii) Focus Group Discussion (FGD) among clinicians and nurses attending to patients at a referral provincial hospital in western Kenya, and (iv) chart abstraction from the Maternal Child Health (MCH) and HIV clinics at the same hospital. Using the January 2014 release of SNOMED CT, concepts were retrieved that matched terms abstracted from approach iii & iv, and the content coverage assessed. Post-coordination matching was applied when needed. Results The final reference set had 1054 unique ADI concepts which were described by 1860 unique terms. Content coverage of SNOMED CT was high (99.9% with pre-coordinated concepts; 100% with post-coordination). The resulting reference set for ADIs was implemented as the interface terminology on OpenMRS data entry forms. Conclusion Different sources demonstrate complementarity in the collection of concepts and terms for an interface terminology. SNOMED CT provides a high coverage in the domain of ADIs. Further work is needed to evaluate the effect of the interface terminology on data quality and quality of care. PMID:26184057

The Empirical Foundations of Teledermatology: A Review of the Research Evidence

PubMed Central

Shannon, Gary W.; Tejasvi, Trilokraj; Kvedar, Joseph C.; Gates, Michael

2015-01-01

Abstract Introduction: This article presents the scientific evidence for the merit of telemedicine interventions in the diagnosis and management of skin disorders (teledermatology) in the published literature. The impetus for this work derives from the high prevalence of skin disorders, the high cost, the limited availability of dermatologists in certain areas, and the promise of teledermatology to address unmet needs in this area. Materials and Methods: The findings are based on a targeted review of scientific studies published from January 2005 through April 2015. The initial search yielded some 5,020 articles in Google Scholar and 428 in PubMed. A review of the abstracts yielded 71 publications that met the inclusion criteria for this analysis. Evidence is organized according to the following: feasibility and acceptance; intermediate outcomes (use of service, compliance, and diagnostic and treatment concordance and accuracy); outcomes (health improvement and problem resolution); and cost savings. A special section is devoted to studies conducted at the Veterans Health Administration. Results: Definitions of teledermatology varied across a wide spectrum of skin disorders, technologies, diagnostic tools, provider types, settings, and patient populations. Outcome measures included diagnostic concordance, treatment plans, and health. Conclusions: Despite these complexities, sufficient evidence was observed consistently supporting the effectiveness of teledermatology in improving accessibility to specialty care, diagnostic and treatment concordance, and skin care provided by primary care physicians, while also reducing cost. One study reported suboptimal clinical results from teledermatology for patients with pigmented skin lesions. On the other hand, confocal microscopy and advanced dermoscopy improved diagnostic accuracy, especially when rendered by experienced teledermatologists. PMID:26394022

TECHNOLOGICAL INFORMATION REGARDING PREBIOTICS AND PROBIOTICS NUTRITION VERSUS THE PATENT REGISTERS: WHAT IS NEW?

PubMed Central

dos REIS, José Maciel Caldas; PINHEIRO, Maurício Fortuna; OTI, André Takashi; FEITOSA-JUNIOR, Denilson José Silva; PANTOJA, Mauro de Souza; BARROS, Rui Sérgio Monteiro

2016-01-01

ABSTRACT Introduction: Food is a key factor both in prevention and in promoting human health. Among the functional food are highlighted probiotics and prebiotics. Patent databases are the main source of technological information about innovation worldwide, providing extensive library for research sector. Objective: Perform mapping in the main patent databases about pre and probiotics, seeking relevant information regarding the use of biotechnology, nanotechnology and genetic engineering in the production of these foods. Method: Electronic consultation was conducted (online) in the main public databases of patents in Brazil (INPI), United States (USPTO) and the European Patent Bank (EPO). The research involved the period from January 2014 to July 2015, being used in the title fields and summary of patents, the following descriptors in INPI "prebiotic", "prebiotic" "probiotics", "probiotic" and the USPTO and EPO: "prebiotic", "prebiotics", "probiotic", "probiotics". Results: This search haven't found any deposit at the brazilian patents website (INPI) in this period; US Patent &Trademark Office had registered 60 titles in patents and the European Patent Office (EPO) showed 10 documents on the issue. Conclusion: Information technology offered by genetic engineering, biotechnology and nanotechnology deposited in the form of titles and abstracts of patents in relation to early nutritional intervention as functional foods, has increasingly required to decrease the risks and control the progression of health problems. But, the existing summaries, although attractive and promising in this sense, are still incipient to recommend them safely as a therapeutic tool. Therefore, they should be seen more as diet elements and healthy lifestyles. PMID:28076487

MRSA: treating people with infection

PubMed Central

2016-01-01

Introduction Methicillin-resistant Staphylococcus aureus (MRSA) has a gene that makes it resistant to methicillin, as well as to other beta-lactam antibiotics, including flucloxacillin, beta-lactam/beta-lactamase inhibitor combinations, cephalosporins, and carbapenems. MRSA can be part of the normal body flora (colonisation), especially in the nose, but it can cause infection, particularly in people with prolonged hospital admissions, with underlying disease, or after antibiotic use. About 8% of S aureus in blood cultures in England, Wales, and Northern Ireland is resistant to methicillin. Methods and outcomes We conducted a systematic overview, aiming to answer the following clinical question: What are the effects of selected treatments for MRSA infections at any body site? We searched: Medline, Embase, The Cochrane Library, and other important databases up to June 2014 (BMJ Clinical Evidence overviews are updated periodically; please check our website for the most up-to-date version of this overview). Results At this update, searching of electronic databases retrieved 312 studies. After deduplication and removal of conference abstracts, 133 records were screened for inclusion in the overview. Appraisal of titles and abstracts led to the exclusion of 55 studies and the further review of 78 full publications. Of the 78 full articles evaluated, 15 systematic reviews and one subsequent RCT were added at this update. In addition, six studies were added to the Comment sections. We performed a GRADE evaluation for 12 PICO combinations. Conclusions In this systematic overview we categorised the efficacy for five interventions, based on information about the effectiveness and safety of cephalosporins (ceftobiprole, ceftaroline), daptomycin, linezolid, quinupristin-dalfopristin, pristinamycin (streptogramins), and tigecycline. PMID:26881888

Fundus Photography in the 21st Century—A Review of Recent Technological Advances and Their Implications for Worldwide Healthcare

PubMed Central

Panwar, Nishtha; Huang, Philemon; Lee, Jiaying; Keane, Pearse A.; Chuan, Tjin Swee; Richhariya, Ashutosh; Teoh, Stephen; Lim, Tock Han

2016-01-01

Abstract Background: The introduction of fundus photography has impacted retinal imaging and retinal screening programs significantly. Literature Review: Fundus cameras play a vital role in addressing the cause of preventive blindness. More attention is being turned to developing countries, where infrastructure and access to healthcare are limited. One of the major limitations for tele-ophthalmology is restricted access to the office-based fundus camera. Results: Recent advances in access to telecommunications coupled with introduction of portable cameras and smartphone-based fundus imaging systems have resulted in an exponential surge in available technologies for portable fundus photography. Retinal cameras in the near future would have to cater to these needs by featuring a low-cost, portable design with automated controls and digitalized images with Web-based transfer. Conclusions: In this review, we aim to highlight the advances of fundus photography for retinal screening as well as discuss the advantages, disadvantages, and implications of the various technologies that are currently available. PMID:26308281

Annual Quality Assurance Conference Files by Tom Mancuso

EPA Pesticide Factsheets

25th Annual Quality Assurance Conference. Abstract: Learn about the NEW EPA Method 325b for Refinery Fence Line Monitoring and TO-17 Extended for Soil Gas by Tom Mancuso and Abstract: Success Using Alternate Carrier Gases for Volatile Methods

Apparatuses and Methods for Producing Runtime Architectures of Computer Program Modules

NASA Technical Reports Server (NTRS)

Abi-Antoun, Marwan Elia (Inventor); Aldrich, Jonathan Erik (Inventor)

2013-01-01

Apparatuses and methods for producing run-time architectures of computer program modules. One embodiment includes creating an abstract graph from the computer program module and from containment information corresponding to the computer program module, wherein the abstract graph has nodes including types and objects, and wherein the abstract graph relates an object to a type, and wherein for a specific object the abstract graph relates the specific object to a type containing the specific object; and creating a runtime graph from the abstract graph, wherein the runtime graph is a representation of the true runtime object graph, wherein the runtime graph represents containment information such that, for a specific object, the runtime graph relates the specific object to another object that contains the specific object.

Information processing systems, reasoning modules, and reasoning system design methods

DOEpatents

Hohimer, Ryan E.; Greitzer, Frank L.; Hampton, Shawn D.

2016-08-23

Information processing systems, reasoning modules, and reasoning system design methods are described. According to one aspect, an information processing system includes working memory comprising a semantic graph which comprises a plurality of abstractions, wherein the abstractions individually include an individual which is defined according to an ontology and a reasoning system comprising a plurality of reasoning modules which are configured to process different abstractions of the semantic graph, wherein a first of the reasoning modules is configured to process a plurality of abstractions which include individuals of a first classification type of the ontology and a second of the reasoning modules is configured to process a plurality of abstractions which include individuals of a second classification type of the ontology, wherein the first and second classification types are different.

Information processing systems, reasoning modules, and reasoning system design methods

DOEpatents

Hohimer, Ryan E.; Greitzer, Frank L.; Hampton, Shawn D.

2015-08-18

Information processing systems, reasoning modules, and reasoning system design methods are described. According to one aspect, an information processing system includes working memory comprising a semantic graph which comprises a plurality of abstractions, wherein the abstractions individually include an individual which is defined according to an ontology and a reasoning system comprising a plurality of reasoning modules which are configured to process different abstractions of the semantic graph, wherein a first of the reasoning modules is configured to process a plurality of abstractions which include individuals of a first classification type of the ontology and a second of the reasoning modules is configured to process a plurality of abstractions which include individuals of a second classification type of the ontology, wherein the first and second classification types are different.

Information processing systems, reasoning modules, and reasoning system design methods

DOEpatents

Hohimer, Ryan E; Greitzer, Frank L; Hampton, Shawn D

2014-03-04

Information processing systems, reasoning modules, and reasoning system design methods are described. According to one aspect, an information processing system includes working memory comprising a semantic graph which comprises a plurality of abstractions, wherein the abstractions individually include an individual which is defined according to an ontology and a reasoning system comprising a plurality of reasoning modules which are configured to process different abstractions of the semantic graph, wherein a first of the reasoning modules is configured to process a plurality of abstractions which include individuals of a first classification type of the ontology and a second of the reasoning modules is configured to process a plurality of abstractions which include individuals of a second classification type of the ontology, wherein the first and second classification types are different.

Gating the holes in the Swiss cheese (part I): Expanding professor Reason's model for patient safety

PubMed Central

Bryan Young, G.; Makhinson, Michael; Smith, Preston A.; Stobart, Kent; Croskerry, Pat

2017-01-01

Abstract Introduction Although patient safety has improved steadily, harm remains a substantial global challenge. Additionally, safety needs to be ensured not only in hospitals but also across the continuum of care. Better understanding of the complex cognitive factors influencing health care–related decisions and organizational cultures could lead to more rational approaches, and thereby to further improvement. Hypothesis A model integrating the concepts underlying Reason's Swiss cheese theory and the cognitive‐affective biases plus cascade could advance the understanding of cognitive‐affective processes that underlie decisions and organizational cultures across the continuum of care. Methods Thematic analysis, qualitative information from several sources being used to support argumentation. Discussion Complex covert cognitive phenomena underlie decisions influencing health care. In the integrated model, the Swiss cheese slices represent dynamic cognitive‐affective (mental) gates: Reason's successive layers of defence. Like firewalls and antivirus programs, cognitive‐affective gates normally allow the passage of rational decisions but block or counter unsounds ones. Gates can be breached (ie, holes created) at one or more levels of organizations, teams, and individuals, by (1) any element of cognitive‐affective biases plus (conflicts of interest and cognitive biases being the best studied) and (2) other potential error‐provoking factors. Conversely, flawed decisions can be blocked and consequences minimized; for example, by addressing cognitive biases plus and error‐provoking factors, and being constantly mindful. Informed shared decision making is a neglected but critical layer of defence (cognitive‐affective gate). The integrated model can be custom tailored to specific situations, and the underlying principles applied to all methods for improving safety. The model may also provide a framework for developing and evaluating strategies to optimize organizational cultures and decisions. Limitations The concept is abstract, the model is virtual, and the best supportive evidence is qualitative and indirect. Conclusions The proposed model may help enhance rational decision making across the continuum of care, thereby improving patient safety globally. PMID:29168290

Abstracts of Research Papers 1970.

ERIC Educational Resources Information Center

Drowatzky, John N., Ed.

This publication includes the abstracts of 199 research papers presented at the 1970 American Association for Health, Physical Education, and Recreation convention in Seattle, Washington. Abstracts from symposia on environmental quality education, obesity, motor development, research methods, and laboratory equipment are also included. Each…

Generic robot architecture

DOEpatents

Bruemmer, David J [Idaho Falls, ID; Few, Douglas A [Idaho Falls, ID

2010-09-21

The present invention provides methods, computer readable media, and apparatuses for a generic robot architecture providing a framework that is easily portable to a variety of robot platforms and is configured to provide hardware abstractions, abstractions for generic robot attributes, environment abstractions, and robot behaviors. The generic robot architecture includes a hardware abstraction level and a robot abstraction level. The hardware abstraction level is configured for developing hardware abstractions that define, monitor, and control hardware modules available on a robot platform. The robot abstraction level is configured for defining robot attributes and provides a software framework for building robot behaviors from the robot attributes. Each of the robot attributes includes hardware information from at least one hardware abstraction. In addition, each robot attribute is configured to substantially isolate the robot behaviors from the at least one hardware abstraction.

Automatic Processing of Metallurgical Abstracts for the Purpose of Information Retrieval. Final Report.

ERIC Educational Resources Information Center

Melton, Jessica S.

Objectives of this project were to develop and test a method for automatically processing the text of abstracts for a document retrieval system. The test corpus consisted of 768 abstracts from the metallurgical section of Chemical Abstracts (CA). The system, based on a subject indexing rational, had two components: (1) a stored dictionary of words…

Synthesis, characterization, and application of two Al(OR(F))3 Lewis superacids.

PubMed

Kraft, Anne; Trapp, Nils; Himmel, Daniel; Böhrer, Hannes; Schlüter, Peter; Scherer, Harald; Krossing, Ingo

2012-07-23

We report herein the synthesis and full characterization of the donor-free Lewis superacids Al(OR(F))(3) with OR(F) = OC(CF(3))(3) (1) and OC(C(5)F(10))C(6)F(5) (2), the stabilization of 1 as adducts with the very weak Lewis bases PhF, 1,2-F(2)C(6)H(4), and SO(2), as well as the internal C-F activation pathway of 1 leading to Al(2)(F)(OR(F))(5) (4) and trimeric [FAl(OR(F))(2)](3) (5, OR(F) = OC(CF(3))(3)). Insights have been gained from NMR studies, single-crystal structure determinations, and DFT calculations. The usefulness of these Lewis acids for halide abstractions has been demonstrated by reactions with trityl chloride (NMR; crystal structures). The trityl salts allow the introduction of new, heteroleptic weakly coordinating [Cl-Al(OR(F))(3)](-) anions, for example, by hydride or alkyl abstraction reactions. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Geophysical abstracts 167, October-December 1956

USGS Publications Warehouse

Rabbitt, Mary C.; Vitaliano, Dorothy B.; Vesselowsky, S.T.; ,

1956-01-01

Geophysical Abstracts includes abstracts of technical papers and books on the physics of the solid earth, the application of physical methods and techniques to geologic problems, and geophysical exploration. The table of contents, which is alphabetically arranged, shows the material covered.Abstracts are prepared only of material that is believed to be generally available. Ordinarily abstracts are not published of material with limited circulation (such as dissertations, open-file reports, or memoranda) or of other papers presented orally at meetings unless summaries of substantial length are published. Abstracts of papers in Japanese and Chinese are based on abstracts or summaries in a western language accompanying the paper.

Geophysical abstracts 164, January-March 1956

USGS Publications Warehouse

Rabbitt, Mary C.; Vitaliano, Dorothy B.; Vesselowsky, S.T.; ,

1956-01-01

Geophysical Abstracts includes abstracts of technical papers and books on the physics of the solid earth, the application of physical methods and techniques to geologic problems, and geophysical exploration. A new table of contents, alphabetically arranged, has been adapted to show more clearly the material covered.Abstracts are prepared only of material that is believed to be generally available. Ordinarily abstracts are not published of material with limited circulation (such as dissertations, open-file reports, or memoranda) or of papers presented orally at meetings unless summaries of substantial length are published. Abstracts of papers in Japanese and Chinese are based on abstracts or summaries in a western language accompanying the paper.

Geophysical abstracts 166, July-September 1956

USGS Publications Warehouse

Rabbitt, Mary C.; Vitaliano, Dorothy B.; Vesselowsky, S.T.; ,

1956-01-01

Geophysical Abstracts includes abstracts of technical papers and books on the physics of the solid earth, the application of physical methods and techniques to geologic problems, and geophysical exploration. The table of contents, which is alphabetically arranged, shows the material covered.Abstracts are prepared only of material that is believed to be generally available. Ordinarily abstracts are not published of material with limited circulation (such as dissertations, open-file reports, or memoranda) or of other papers presented orally at meetings unless summaries of substantial length are published. Abstracts of papers in Japanese and Chinese are based on abstracts or summaries in a western language accompanying the paper.

Geophysical abstracts 165, April-June 1956

USGS Publications Warehouse

Rabbitt, Mary C.; Vitaliano, Dorothy B.; Vesselowsky, S.T.; ,

1956-01-01

Geophysical Abstracts includes abstracts of technical papers and books on the physics of the solid earth, the application of physical methods and techniques to geologic problems, and geophysical exploration. The table of contents, which is alphabetically arranged, shows the material covered.Abstracts are prepared only of material that is believed to be generally available. Ordinarily abstracts are not published of material with limited circulation (such as dissertations, open-file reports, or memoranda) or of other papers presented orally at meetings unless summaries of substantial length are published. Abstracts of papers in Japanese and Chinese are based on abstracts or summaries in a western language accompanying the paper.

Modified Multiple Model Adaptive Estimation (M3AE) for Simultaneous Parameter and State Estimation

DTIC Science & Technology

1998-03-01

Contents Page Dedication : iv Acknowledgments v Table Of Contents vi List of Figures . . ; x List of Tables xv Abstract xvii Chapter 1 ...INTRODUCTION 1 1.1 Overview 1 1.2 Background 7 1.2.1 The Chi-Square Test 9 1.2.2 Generalized Likelihood Ratio (GLR) Testing 10 1.2.3 Multiple...M3AE Covariance Analysis 115 4.1.3 Simulations and Performance Analysis 121 4.1.3.1 Test Case 1 : aT = 32.0 124 4.1.3.2 Test Case 2: aT = 37.89, and

Exploration in the Complexity of Possible Life: Abstracting and Synthesizing the Principles of Living Systems - Proceedings of the German Workshop on Artificial Life (7th) Held in Jena, Germany on 26-28 Jul 2006

DTIC Science & Technology

2006-01-01

artificial chemistry. 1 Introduction Chemical evolution (i.e., prebiotic evolution) is concerned with the period of life’s history that precedes the...arrival of the first living organism [17]. Since Miller’s pioneering work [19, 20], prebiotic chemistry has been studied in various laboratory...Bada. The 1953 Stanley L. Miller experiment: fifty years of prebiotic organic chemistry. Orig Life Evol Biosph, 33(3):235–42, 2003. 145 [17] J. Maynard

Testing Current and Developing Novel Therapies for NF1-Mutant Sarcomas in a Genetically Engineered Mouse Model

DTIC Science & Technology

2015-04-01

Patients with Neurofibromatosis type 1 (NF1) are at increased risk for developing malignant tumors of the connective tissue called soft-tissue sarcomas...mouse model, MPNST, Neurofibromatosis , NF1 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT 18. NUMBER OF PAGES 19a. NAME OF RESPONSIBLE...9 9. Appendices……………………………………………………………9 4   1. INTRODUCTION: Patients with Neurofibromatosis type 1 (NF1) are at increased risk for

Interventions for Sustainable Weight Loss in Military Families

DTIC Science & Technology

2016-05-01

recruiting, military bases, obesity 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT 18. NUMBER OF PAGES 19a. NAME OF RESPONSIBLE PERSON...10 8. Special Reporting Requirements……………………………………10 9. Appendices……………………………………………………………10 4 1. INTRODUCTION: Obesity and overweight are at epidemic...test an innovative behavioral intervention in a clinical trial of overweight and obese adult dependents of active duty military personnel (ADMP) and

Case Management of Dengue: Lessons Learned

PubMed Central

Kalayanarooj, Siripen; Srikiatkhachorn, Anon

2017-01-01

Abstract The global burden of dengue and its geographic distribution have increased over the past several decades. The introduction of dengue in new areas has often been accompanied by high case-fatality rates. Drawing on the experience in managing dengue cases at the Queen Sirikit National Institute of Child Health in Bangkok, Thailand, this article provides the authors’ perspectives on key clinical lessons to improve dengue-related outcomes. Parallels between this clinical experience and outcomes reported in randomized controlled trials, results of efforts to disseminate practice recommendations, and suggestions for areas for further research are also discussed. PMID:28403440

A Regularized Neural Net Approach for Retrieval of Atmospheric and Surface Temperatures with the IASI Instrument

NASA Technical Reports Server (NTRS)

Aires, F.; Chedin, A.; Scott, N. A.; Rossow, W. B.; Hansen, James E. (Technical Monitor)

2001-01-01

Abstract In this paper, a fast atmospheric and surface temperature retrieval algorithm is developed for the high resolution Infrared Atmospheric Sounding Interferometer (IASI) space-borne instrument. This algorithm is constructed on the basis of a neural network technique that has been regularized by introduction of a priori information. The performance of the resulting fast and accurate inverse radiative transfer model is presented for a large divE:rsified dataset of radiosonde atmospheres including rare events. Two configurations are considered: a tropical-airmass specialized scheme and an all-air-masses scheme.

The NASA ADS Abstract Service and the Distributed Astronomy Digital Library [and] Project Soup: Comparing Evaluations of Digital Collection Efforts [and] Cross-Organizational Access Management: A Digital Library Authentication and Authorization Architecture [and] BibRelEx: Exploring Bibliographic Databases by Visualization of Annotated Content-based Relations [and] Semantics-Sensitive Retrieval for Digital Picture Libraries [and] Encoded Archival Description: An Introduction and Overview.

ERIC Educational Resources Information Center

Kurtz, Michael J.; Eichorn, Guenther; Accomazzi, Alberto; Grant, Carolyn S.; Demleitner, Markus; Murray, Stephen S.; Jones, Michael L. W.; Gay, Geri K.; Rieger, Robert H.; Millman, David; Bruggemann-Klein, Anne; Klein, Rolf; Landgraf, Britta; Wang, James Ze; Li, Jia; Chan, Desmond; Wiederhold, Gio; Pitti, Daniel V.

1999-01-01

Includes six articles that discuss a digital library for astronomy; comparing evaluations of digital collection efforts; cross-organizational access management of Web-based resources; searching scientific bibliographic databases based on content-based relations between documents; semantics-sensitive retrieval for digital picture libraries; and…

Joint Peru/United States report on Peru/United States cooperative energy assessment. Volume 2. Annex 1

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1979-08-01

An examination of the energy sources of Peru was undertaken by the USA in collaboration with Peru. First, an introduction establishes the purpose and summarizes results, after which the status of energy supply is presented. The ensuing sections contain the contributions of the participating technical specialists, namely: Peru's hydrocarbon potential, estimated reserves, and projected production rates; coal deposits in Peru; geothermal energy; uranium; miscellaneous energy sources; energy-related minerals; water resources in Peru; and geologic hazards in Peru. A separate abstract was prepared for each of the sections. (MCW)

A Novel Approach for Effectively Treating SCI Pain, Improving Opioid Efficacy, and Preventing Opioid-Induced Constipation: Key Role of Toll-Like Receptor 4 (TLR4)

DTIC Science & Technology

2016-12-01

Approved for Public Release; Distribution Unlimited 13. SUPPLEMENTARY NOTES 14. ABSTRACT Spinal cord injury (SCI) is a disabling and costly condition...23 11. Appendices…………………………………………………………. 24 INTRODUCTION   Spinal cord injury (SCI) is a disabling and costly condition... learned everything taught in the renowned Spinal Cord Injury Training Program. Since Gaudet already has training in SCI research, further training

Introduction: Untold Legacies of the First World War in Britain

PubMed Central

Fell, Alison S.; Meyer, Jessica

2015-01-01

Abstract The current centenary of the First World War provides an unrivalled opportunity to uncover some of the social legacies of the war. The four articles which make up this special issue each examine a different facet of the war’s impact on British society to explore an as yet untold story. The subjects investigated include logistics, the history of science, the social history of medicine and resistance to war. This article introduces the four which follow, locating them in the wider historiographic debates around the interface between warfare and societies engaged in war. PMID:27453628

Policy and programmatic considerations for introducing a longer-acting injectable contraceptive: perspectives of stakeholders from Kenya and Rwanda

PubMed Central

McKenna, Kevin; Arcara, Jennet; Rademacher, Kate H; Mackenzie, Caroline; Ngabo, Fidele; Munyambanza, Emmanuel; Wesson, Jennifer; Tolley, Elizabeth E

2014-01-01

ABSTRACT Background: More than 40 million women use injectable contraceptives to prevent pregnancy, and most current or previous injectable users report being satisfied with the method. However, while women may find injectables acceptable, they may not always find them accessible due to stock-outs and difficulties with returning to the clinic for reinjections. FHI 360 is spearheading efforts to develop a longer-acting injectable (LAI) contraceptive that could provide at least 6 months of protection against pregnancy. This article addresses systems-level considerations for the introduction of a new LAI. Methods: We conducted qualitative case studies in Kenya and Rwanda—two countries that have high levels of injectable use but with different service delivery contexts. Between June and September 2012, we conducted in-depth interviews with 27 service providers and 19 policy makers and program implementers focusing on 4 themes: systems-level barriers and facilitators to delivering LAI services; process for introducing an LAI; LAI distribution approaches; and potential LAI characteristics. We also obtained electronic feedback from 28 international family planning opinion leaders. Results: Respondents indicated strong interest in an LAI and thought it would appeal to existing injectable users as well as new family planning clients, both for spacing and for limiting births. Providers appreciated the potential for a lighter workload due to fewer follow-up visits, but they were concerned that fewer visits would also decrease their ability to help women manage side effects. The providers also appreciated the 1-month grace period for follow-up LAI injections; some seemed unaware of the latest international guidance that had increased the grace period from 2 weeks to 4 weeks for the currently available 3-month injectable. The majority of policy makers and program implementers were supportive of letting community health workers provide the method, but many nurses and midwives in Kenya had reservations about the approach. At the policy level, respondents indicated that obtaining regulatory approvals before introducing the new method could be costly and time-consuming. Manufacturing and procurement decisions could also affect cost and availability. Conclusions: Successful introduction of a potential longer-acting injectable may be enhanced by considering broader systemic issues, including managing cost to the health system and users, expanding access through community-based distribution, and training providers on the latest service delivery guidelines. PMID:25611479

Localization Versus Abstraction: A Comparison of Two Search Reduction Techniques

NASA Technical Reports Server (NTRS)

Lansky, Amy L.

1992-01-01

There has been much recent work on the use of abstraction to improve planning behavior and cost. Another technique for dealing with the inherently explosive cost of planning is localization. This paper compares the relative strengths of localization and abstraction in reducing planning search cost. In particular, localization is shown to subsume abstraction. Localization techniques can model the various methods of abstraction that have been used, but also provide a much more flexible framework, with a broader range of benefits.

Air Pollution Translations: A Bibliography with Abstracts - Volume 4.

ERIC Educational Resources Information Center

Environmental Protection Agency, Research Triangle Park, NC. Air Pollution Technical Information Center.

This volume is the fourth in a series of compilations presenting abstracts and indexes of translations of technical air pollution literature. The entries are grouped into 12 subject categories: Emission Sources, Control Methods, Measurement Methods, Air Quality Measurements, Atmospheric Interaction, Basic Science and Technology, Effects--Human…

Introduction and Effectiveness of New Methods of Instruction Using Literature in a Japanese High School Setting

ERIC Educational Resources Information Center

Richings, Vicky Ann; Nishimuro, Masateru

2017-01-01

This paper reports on findings from a classroom study on the introduction and effectiveness of new methods of instruction using English literature in a Japanese high school setting. It is based on data compiled during a two-year research project. In this paper, we will detail the investigation and findings from an analysis of student questionnaire…

Evolutionary computation in zoology and ecology

PubMed Central

2017-01-01

Abstract Evolutionary computational methods have adopted attributes of natural selection and evolution to solve problems in computer science, engineering, and other fields. The method is growing in use in zoology and ecology. Evolutionary principles may be merged with an agent-based modeling perspective to have individual animals or other agents compete. Four main categories are discussed: genetic algorithms, evolutionary programming, genetic programming, and evolutionary strategies. In evolutionary computation, a population is represented in a way that allows for an objective function to be assessed that is relevant to the problem of interest. The poorest performing members are removed from the population, and remaining members reproduce and may be mutated. The fitness of the members is again assessed, and the cycle continues until a stopping condition is met. Case studies include optimizing: egg shape given different clutch sizes, mate selection, migration of wildebeest, birds, and elk, vulture foraging behavior, algal bloom prediction, and species richness given energy constraints. Other case studies simulate the evolution of species and a means to project shifts in species ranges in response to a changing climate that includes competition and phenotypic plasticity. This introduction concludes by citing other uses of evolutionary computation and a review of the flexibility of the methods. For example, representing species’ niche spaces subject to selective pressure allows studies on cladistics, the taxon cycle, neutral versus niche paradigms, fundamental versus realized niches, community structure and order of colonization, invasiveness, and responses to a changing climate. PMID:29492029

The Effect of Photodynamic Therapy in the Treatment of Chronic Periodontitis: A Review of Literature.

PubMed

Meimandi, Mansour; Talebi Ardakani, Mohammad Reza; Esmaeil Nejad, Azadeh; Yousefnejad, Parisa; Saebi, Khosro; Tayeed, Mohammad Hossein

2017-01-01

Introduction: Chronic periodontitis is the most common periodontal disease which is related to the chronic accumulation of bacterial plaque. Since mechanical methods are not sufficient in the treatment of this disease, administration of local/systemic antibiotic is recommended following mechanical debridement. However, side effects of antibiotics such as microbial resistance and patient allergy led to development of alternative methods. One of these suggested methods is the antimicrobial photodynamic therapy (aPDT). PDT is a local noninvasive treatment modality without the side effects caused by antibiotics. The aim of this study was to review the articles related to the application of PDT with laser in the treatment of chronic periodontitis. Review of literature: In the present review of literature, the authors used key words such as chronic periodontitis, laser and photodynamic therapy, and conducted a literature search via Google Scholar and PubMed for the period of 1990 to 2015. A total of 47 articles in English were found. The articles that were not associated with the topic of research and review articles were deleted and only clinical trials were evaluated. After reviewing 23 articles' abstracts, the full texts of 16 articles were analyzed. Conclusion: Considering the safety, the lack of side effects and general advantages like more patient compliance, the PDT treatment with scaling and root planing (SRP) is recommended as an efficient adjunctive modality for the treatment of localized chronic periodontitis especially during the maintenance phase in non-surgical treatment.

Development of a Teen-Focused Exergame

PubMed Central

Thompson, Debbe; Cantu, Dora; Rajendran, Madhur; Rajendran, Mayur; Bhargava, Tanay; Zhang, Yuting; Chen, Cheng; Liu, Yan

2016-01-01

Abstract Introduction: Exergames require body movement to play and may be an effective method for enhancing teen physical activity (PA). However, results have been mixed. Innovative methods are needed to develop Exergames that increase and maintain PA. Self-representational avatars, or avatars created from a digital image of an individual, may increase PA (e.g., intensity, duration) during Exergame play. This article addresses this novel idea by describing the development of an Exergame played with a self-representational avatar. Materials and Methods: Twelve- to 14-year-olds, stratified by gender, body mass index, and PA, were invited to participate in two rounds of data collection. Each round consisted of an online survey, followed by a telephone interview to ensure comprehension of survey responses. After the first round, an Exergame prototype and the system for creating the self-representational avatar were created. A second round of data was collected to obtain information with which to create a fully functional Exergame and the avatar creation system. Results: Forty-eight teens were recruited. The sample was multi-ethnic (41.7% White, 37.5% Black, 18.8% Hispanic, 2.1% Mixed/Other). Complete data were obtained on 48 teens in the first round of data collection and on 43 teens in the second round. Teens provided important information regarding preferences and expectations. Gender similarities and differences were observed. Conclusion: This research contributes to the body of knowledge regarding how to design an appealing Exergame for teens navigated by a self-representational avatar. PMID:27680385

Air Pollution Translations: A Bibliography with Abstracts - Volume 2.

ERIC Educational Resources Information Center

National Air Pollution Control Administration (DHEW), Raleigh, NC.

This volume is the second in a series of compilations presenting abstracts and indexes of translations of technical air pollution literature. The 444 entries are grouped into 12 subject categories: General; Emission Sources; Atmospheric Interaction; Measurement Methods; Control Methods; Effects--Human Health; Effects--Plants and Livestock;…

Dynamics of Colonization of Streptococcus pneumoniae Strains in Healthy Peruvian Children

PubMed Central

Nelson, Kristin N; Grijalva, Carlos G; Chochua, Sopio; Hawkins, Paulina A; Gil, Ana I; Lanata, Claudio F; Griffin, Marie R; Edwards, Kathryn M; Klugman, Keith P; Vidal, Jorge E

2018-01-01

Abstract Background Although asymptomatic carriage of Streptococcus pneumoniae (Spn) is common, acquisition of the bacteria is the first step in disease pathogenesis. We examined the effect of introduction of the 7-valent pneumococcal vaccine on Spn carriage patterns in a cohort of Peruvian children. Methods We used data from a prospective cohort study that collected monthly nasopharyngeal samples from children under 3 years of age. Spn isolates were serotyped using Quellung reactions, and bacterial density was determined by quantitative polymerase chain reaction. Changes in Spn carriage patterns, including the rate of carriage and number and density of serotypes carried over time, were evaluated before (2009) and after widespread vaccination with PCV7 (2011). Using all pneumococcal detections from each child and year, we identified serotypes that were present both at first and last detection as “persisters” and serotypes that replaced a different earlier type and were detected last as “recolonizers.” Results Ninety-two percent (467/506) of children in 2009 and 89% (451/509) in 2011 carried Spn at least once. In 2009 and 2011, rates of carriage were 9.03 and 9.04 Spn detections per person-year, respectively. In 2009, 23F, a serotype included in PCV7, was the only type identified as a persister and 6A, 15B, and 19A were identified as recolonizer serotypes. In 2011, 6B and 7C were persister serotypes and 13 was a frequent recolonizer serotype. Conclusions Overall Spn carriage among children under 3 in Peru was similar before and after introduction of PCV7; however, serotype-specific rates and longitudinal carriage patterns have shifted. PMID:29588913

Etiology of Severe Acute Watery Diarrhea in Children in the Global Rotavirus Surveillance Network Using Quantitative Polymerase Chain Reaction

PubMed Central

Operario, Darwin J; Platts-Mills, James A; Nadan, Sandrama; Page, Nicola; Seheri, Mapaseka; Mphahlele, Jeffrey; Praharaj, Ira; Kang, Gagandeep; Araujo, Irene T; Leite, Jose Paulo G; Cowley, Daniel; Thomas, Sarah; Kirkwood, Carl D; Dennis, Francis; Armah, George; Mwenda, Jason M; Wijesinghe, Pushpa Ranjan; Rey, Gloria; Grabovac, Varja; Berejena, Chipo; Simwaka, Chibumbya J; Uwimana, Jeannine; Sherchand, Jeevan B; Thu, Hlaing Myat; Galagoda, Geethani; Bonkoungou, Isidore J O; Jagne, Sheriffo; Tsolenyanu, Enyonam; Diop, Amadou; Enweronu-Laryea, Christabel; Borbor, Sam-Aliyah; Liu, Jie; McMurry, Timothy; Lopman, Benjamin; Parashar, Umesh; Gentsch, John; Steele, A Duncan; Cohen, Adam; Serhan, Fatima; Houpt, Eric R

2017-01-01

Abstract Background The etiology of acute watery diarrhea remains poorly characterized, particularly after rotavirus vaccine introduction. Methods We performed quantitative polymerase chain reaction for multiple enteropathogens on 878 acute watery diarrheal stools sampled from 14643 episodes captured by surveillance of children <5 years of age during 2013–2014 from 16 countries. We used previously developed models of the association between pathogen quantity and diarrhea to calculate pathogen-specific weighted attributable fractions (AFs). Results Rotavirus remained the leading etiology (overall weighted AF, 40.3% [95% confidence interval {CI}, 37.6%–44.3%]), though the AF was substantially lower in the Americas (AF, 12.2 [95% CI, 8.9–15.6]), based on samples from a country with universal rotavirus vaccination. Norovirus GII (AF, 6.2 [95% CI, 2.8–9.2]), Cryptosporidium (AF, 5.8 [95% CI, 4.0–7.6]), Shigella (AF, 4.7 [95% CI, 2.8–6.9]), heat-stable enterotoxin-producing Escherichia coli (ST-ETEC) (AF, 4.2 [95% CI, 2.0–6.1]), and adenovirus 40/41 (AF, 4.2 [95% CI, 2.9–5.5]) were also important. In the Africa Region, the rotavirus AF declined from 54.8% (95% CI, 48.3%–61.5%) in rotavirus vaccine age-ineligible children to 20.0% (95% CI, 12.4%–30.4%) in age-eligible children. Conclusions Rotavirus remained the leading etiology of acute watery diarrhea despite a clear impact of rotavirus vaccine introduction. Norovirus GII, Cryptosporidium, Shigella, ST-ETEC, and adenovirus 40/41 were also important. Prospective surveillance can help identify priorities for further reducing the burden of diarrhea. PMID:28838152

The Australian experience following plain packaging: the impact on tobacco branding.

PubMed

Greenland, Steven J

2016-12-01

Brands are critical to tobacco marketing. Industry stakeholders predicted that plain packaging, by removing key tangible branding dimensions, would restrict new products and brand differentiation. However, manufacturers respond innovatively to limit regulatory impact. This study investigates brand strategy following plain packaging's introduction to Australia. Brand portfolios were determined using 2006-15 tobacco ingredient reports. These detail the brand and variant names sold and are provided annually as part of a voluntary agreement between the Australian Government and leading manufacturers. Post-plain packaging brand ranges were verified using retail price lists and a supermarket retail audit using a method used previously to verify a period of pre-plain packaging data. The verification process identified some data inaccuracies from one manufacturer which resulted in the issuing of corrected data. After plain packaging the leading manufacturers continued with extensive brand ranges differentiated by price. All launched new products. While total brand numbers fell from 29 to 24, the mean number of variants for the leading 12 brands grew from 8.9 to 9.7. Substantial variant name modifications occurred with 50 new or modified names in 2012-13. Among leading brands, the incidence of variant colour names increased from 49.5 to 79.3%. New brands and variants were not inhibited by the introduction of plain packaging in Australia. After plain packaging, leading brand variant numbers expanded by 9 to 116 and colour variant names increased by 73.6% and became the norm-lighter colours (blue, gold and silver) dominated, perpetuating notions of less harmful cigarettes. [Correction added on 09 September 2016, after first online publication: The figures in the last sentence of the Abstract are now corrected from 'expanded by 116' to 'expanded by 9 to 116'.]. © 2016 Society for the Study of Addiction.

Robot-assisted laparoscopic radical prostatectomy with early retrograde release of the neurovascular bundle and endopelvic fascia sparing

PubMed Central

de Albuquerque, George Augusto Monteiro Lins; Guglielmetti, Giuliano Betoni; Cordeiro, Maurício Dener; Nahas, William Carlos; Coelho, Rafael Ferreira

2017-01-01

ABSTRACT Introduction Robotic-assisted radical prostatectomy (RAP) is the dominant minimally invasive surgical treatment for patients with localized prostate cancer. The introduction of robotic assistance has the potential to improve surgical outcomes and reduce the steep learning curve associated with conventional laparoscopic radical prostatectomy. The purpose of this video is to demonstrate the early retrograde release of the neurovascular bundle without open the endopelvic fascia during RAP. Materials and Methods A 51-year old male, presenting histological diagnosis of prostate adenocarcinoma, Gleason 6 (3+3), in 4 cores of 12, with an initial PSA=3.41ng/dl and the digital rectal examination demonstrating a prostate with hardened nodule in the right lobe of the prostate base (clinical stage T2a). Surgical treatment with the robot-assisted technique was offered as initial therapeutic option and the critical technical point was the early retrograde release of the neurovascular bundle with endopelvic fascia preservation, during radical prostatectomy. Results The operative time was of 89 minutes, blood loss was 100ml. No drain was left in the peritoneal cavity. The patient was discharged within 24 hours. There were no intraoperative or immediate postoperative complications. The pathological evaluation revealed prostate adenocarcinoma, Gleason 6, with free surgical margins and seminal vesicles free of neoplastic involvement (pathologic stage T2a). At 3-month-follow-up, the patient lies with undetectable PSA, continent and potent. Conclusion This is a feasible technique combining the benefits of retrograde release of the neurovascular bundle, the preservation of the pubo-prostatic collar and the preservation of the antero-lateral cavernous nerves. PMID:27802002

Real-time PCR assay for the diagnosis of pleural tuberculosis

PubMed Central

Cárdenas Bernal, Ana María; Giraldo-Cadavid, Luis Fernando; Prieto Diago, Enrique; Santander, Sandra Paola

2017-01-01

Abstract Introduction: The diagnosis of pleural tuberculosis requires an invasive and time-consuming reference method. Polymerase chain reaction (PCR) is rapid, but validation in pleural tuberculosis is still weak. Objective: To establish the operating characteristics of real-time polymerase chain reaction (RT-PCR) hybridization probes for the diagnosis of pleural tuberculosis. Methods: The validity of the RT-PCR hybridization probes was evaluated compared to a composite reference method by a cross-sectional study at the Hospital Universitario de la Samaritana. 40 adults with lymphocytic pleural effusion were included. Pleural tuberculosis was confirmed (in 9 patients) if the patient had at least one of three tests using the positive reference method: Ziehl-Neelsen or Mycobacterium tuberculosis culture in fluid or pleural tissue, or pleural biopsy with granulomas. Pleural tuberculosis was ruled out (in 31 patients) if all three tests were negative. The operating characteristics of the RT-PCR, using the Mid-P Exact Test, were determined using the OpenEpi 2.3 Software (2009). Results: The RT-PCR hybridization probes showed a sensitivity of 66.7% (95% CI: 33.2%-90.7%) and a specificity of 93.5% (95% CI: 80.3%-98.9%). The PPV was 75.0% (95% CI: 38.8%-95.6%) and a NPV of 90.6% (95% CI: 76.6%-97.6%). Two false positives were found for the test, one with pleural mesothelioma and the other with chronic pleuritis with mesothelial hyperplasia. Conclusions: The RT-PCR hybridization probes had good specificity and acceptable sensitivity, but a negative value cannot rule out pleural tuberculosis. PMID:29021638

Overcoming the Challenges of Unstructured Data in Multisite, Electronic Medical Record-based Abstraction.

PubMed

Polnaszek, Brock; Gilmore-Bykovskyi, Andrea; Hovanes, Melissa; Roiland, Rachel; Ferguson, Patrick; Brown, Roger; Kind, Amy J H

2016-10-01

Unstructured data encountered during retrospective electronic medical record (EMR) abstraction has routinely been identified as challenging to reliably abstract, as these data are often recorded as free text, without limitations to format or structure. There is increased interest in reliably abstracting this type of data given its prominent role in care coordination and communication, yet limited methodological guidance exists. As standard abstraction approaches resulted in substandard data reliability for unstructured data elements collected as part of a multisite, retrospective EMR study of hospital discharge communication quality, our goal was to develop, apply and examine the utility of a phase-based approach to reliably abstract unstructured data. This approach is examined using the specific example of discharge communication for warfarin management. We adopted a "fit-for-use" framework to guide the development and evaluation of abstraction methods using a 4-step, phase-based approach including (1) team building; (2) identification of challenges; (3) adaptation of abstraction methods; and (4) systematic data quality monitoring. Unstructured data elements were the focus of this study, including elements communicating steps in warfarin management (eg, warfarin initiation) and medical follow-up (eg, timeframe for follow-up). After implementation of the phase-based approach, interrater reliability for all unstructured data elements demonstrated κ's of ≥0.89-an average increase of +0.25 for each unstructured data element. As compared with standard abstraction methodologies, this phase-based approach was more time intensive, but did markedly increase abstraction reliability for unstructured data elements within multisite EMR documentation.

Is gastroenterology research in decline? A comparison of abstract publication rates from The British Society of Gastroenterology meetings between 1995 and 2005.

PubMed

Prendergast, Sarah; Mattishent, Katharina; Broughton, Tom; Beales, Ian

2013-01-01

Background: Reports have suggested that academic medicine may be in decline within the UK. Further evidence suggests that rates of subsequent full publication of abstracts presented at major scientific meetings are low and may be declining. We have compared the publication rates of abstracts presented at meetings of the British Society of Gastroenterology (BSG) between 1995 and 2005 and examined factors associated with full paper publication.  Methods: Abstracts presented at BSG meetings in 1995 and 2005 were assessed by cross-referencing with multiple databases. Abstract characteristics associated with publication were analysed. Results: There were no differences in overall publication rates, impact factors or time to publication between 1995 and 2005. Overall, basic-science abstracts were twice as likely to achieve full publication than non-basic science. There was a significant fall in the publication rates for case series and audits, and significantly increased rates for fundamental/basic-science abstracts over the study period. There were non-significant increases in publication rates for controlled trials and systematic reviews. In general, publication rates for all predominantly clinically orientated abstracts reduced between the two periods with the most notable fall occurring in nutrition.  Conclusions: There was no evidence of a decline in overall abstract publication rates between 1995 and 2005. There seemed to be trend for increased publication rates of abstracts using perceived high-quality study methodologies with a corresponding decrease in those with lower quality methods. The proportion of basic-science abstracts is likely to be a determinant of overall full publication rates following scientific meetings.

The global distribution of bamboos: assessing correlates of introduction and invasion

PubMed Central

Richardson, David M.; Visser, Vernon; Le Roux, Johannes J.; Vorontsova, Maria S.; Wilson, John R. U.

2017-01-01

Abstract There is a long history of species being moved around the world by humans. These introduced species can provide substantial benefits, but they can also have undesirable consequences. We explore the importance of human activities on the processes of species dissemination and potential invasions using the Poaceae subfamily Bambusoideae (‘bamboos’), a group that contains taxa that are widely utilised and that are often perceived as weedy. We (1) compiled an inventory of bamboo species and their current distributions; (2) determined which species have been introduced and become invasive outside their native ranges; and (3) explored correlates of introduction and invasion. Distribution data were collated from Kew’s GrassBase, the Global Biodiversity Information Facility and other online herbarium information sources. Our list comprised 1662 species in 121 genera, of which 232 (14 %) have been introduced beyond their native ranges. Twelve (0.7 % of species) were found to be invasive. A non-random selection of bamboos have been introduced and become invasive. Asiatic species in particular have been widely introduced. There was a clear over-representation of introduced species in the genera Bambusa and Phyllostachys which also contain most of the listed invasive species. The introduction of species also correlated with certain traits: taxa with larger culm dimensions were significantly more likely to have been moved to new areas; and those with many cultivars had a higher rate of dissemination and invasion. It is difficult to determine whether the patterns of introduction and invasion are due simply to differences in propagule pressure, or whether humans have deliberately selected inherently invasive taxa. In general, we suggest that human usage is a stronger driver of introductions and invasions in bamboos than in other taxa that have been well studied. It is likely that as bamboos are used more widely, the number and impact of invasions will increase unless environmental risks are carefully managed. PMID:28013249

Abstraction and model evaluation in category learning.

PubMed

Vanpaemel, Wolf; Storms, Gert

2010-05-01

Thirty previously published data sets, from seminal category learning tasks, are reanalyzed using the varying abstraction model (VAM). Unlike a prototype-versus-exemplar analysis, which focuses on extreme levels of abstraction only, a VAM analysis also considers the possibility of partial abstraction. Whereas most data sets support no abstraction when only the extreme possibilities are considered, we show that evidence for abstraction can be provided using the broader view on abstraction provided by the VAM. The present results generalize earlier demonstrations of partial abstraction (Vanpaemel & Storms, 2008), in which only a small number of data sets was analyzed. Following the dominant modus operandi in category learning research, Vanpaemel and Storms evaluated the models on their best fit, a practice known to ignore the complexity of the models under consideration. In the present study, in contrast, model evaluation not only relies on the maximal likelihood, but also on the marginal likelihood, which is sensitive to model complexity. Finally, using a large recovery study, it is demonstrated that, across the 30 data sets, complexity differences between the models in the VAM family are small. This indicates that a (computationally challenging) complexity-sensitive model evaluation method is uncalled for, and that the use of a (computationally straightforward) complexity-insensitive model evaluation method is justified.

Discrepancies Between Plastic Surgery Meeting Abstracts and Subsequent Full-Length Manuscript Publications.

PubMed

Denadai, Rafael; Araujo, Gustavo Henrique; Pinho, Andre Silveira; Denadai, Rodrigo; Samartine, Hugo; Raposo-Amaral, Cassio Eduardo

2016-10-01

The purpose of this bibliometric study was to assess the discrepancies between plastic surgery meeting abstracts and subsequent full-length manuscript publications. Abstracts presented at the Brazilian Congress of Plastic Surgery from 2010 to 2011 were compared with matching manuscript publications. Discrepancies between the abstract and the subsequent manuscript were categorized as major (changes in the purpose, methods, study design, sample size, statistical analysis, results, and conclusions) and minor (changes in the title and authorship) variations. The overall discrepancy rate was 96 %, with at least one major (76 %) and/or minor (96 %) variation. There were inconsistencies between the study title (56 %), authorship (92 %), purpose (6 %), methods (20 %), study design (36 %), sample size (51.2 %), statistical analysis (14 %), results (20 %), and conclusions (8 %) of manuscripts compared with their corresponding meeting abstracts. As changes occur before manuscript publication of plastic surgery meeting abstracts, caution should be exercised in referencing abstracts or altering surgical practices based on abstracts' content. This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

Current Literature on Venereal Disease, 1972. Number Three. Abstracts and Bibliography.

ERIC Educational Resources Information Center

Lea, Mildred V., Ed.

Presented are abstracts of documents and research pertaining to the clinical description, laboratory diagnosis, management, and therapy of syphilis and gonorrhea. Abstracted case studies of other minor venereal and related diseases are also included, as are bibliographies on current research and evaluation, public health methods, and behavioral…

Current Literature on Venereal Disease, 1972. Number Two. Abstracts and Bibliography.

ERIC Educational Resources Information Center

Lea, Mildred V., Ed.

Presented are abstracts of documents and research pertaining to the clinical description, laboratory diagnosis, management, and therapy of syphilis and gonorrhea. Abstracted case studies of other minor venereal and related diseases are also included, as are bibliographies on current research and evaluation, public health methods, and behavioral…

Current Literature on Venereal Disease, 1972. Number One. Abstracts and Bibliography.

ERIC Educational Resources Information Center

Lea, Mildred V., Ed.

Presented are abstracts of documents and research pertaining to the clinical description, laboratory diagnosis, management, and therapy of syphilis and gonorrhea. Abstracted case studies of other minor venereal and related diseases are also included, as are bibliographies on current research and evaluation, public health methods, and behavioral…

[Qualitative research in health services research - discussion paper, Part 2: Qualitative research in health services research in Germany - an overview].

PubMed

Karbach, U; Stamer, M; Holmberg, C; Güthlin, C; Patzelt, C; Meyer, T

2012-08-01

This is the second part of a 3-part discussion paper by the working group on "Qualitative Methods" in the German network of health services research (DNVF) that shall contribute to the development of a memorandum concerning qualitative health services research. It aims to depict the different types of qualitative research that are conducted in health services research in Germany. In addition, the authors present a specific set of qualitative data collection and analysis tools to demonstrate the potential of qualitative research for health services research. QUALITATIVE RESEARCH IN HEALTH SERVICES RESEARCH - AN OVERVIEW: To give an overview of the types of qualitative research conducted in German health services research, the abstracts of the 8th German Conference on Health Services Research were filtered to identify qualitative or mixed-methods studies. These were then analysed by looking at the context which was studied, who was studied, the aims of the studies, and what type of methods were used. Those methods that were mentioned most often for data collection and analysis are described in detail. QUALITATIVE RESEARCH AT THE CONFERENCE FOR HEALTH SERVICES RESEARCH 2009: Approximately a fifth of all abstracts (n=74) had a qualitative (n=47) or a mixed-methods approach combining quantitative and qualitative methods (n=27). Research aims included needs assessment (41%), survey development (36%), evaluation (22%), and theorizing (1%). Data collection mostly consisted of one-on-one interviews (n=45) and group discussions (n=29). Qualitative content analysis was named in 35 abstracts, 30 abstracts did not reference their method of analysis. In addition to a quantitative summary of the abstract findings, the diversity of fields addressed by qualitative methods is highlighted. Although drawing conclusions on the use of qualitative methods in German health services research from the analysis of conference abstracts is not possible, the overview we present demonstrates the diversity of methods used for data collection and analysis and showed that a few select methods are extensively used. One of the tasks a memorandum of qualitative health services research should accomplish is to highlight underutilized research methods, which may help to develop the potential of qualitative methodology in German health services research. © Georg Thieme Verlag KG Stuttgart · New York.

Comparative performance study of different sample introduction techniques for rapid and precise selenium isotope ratio determination using multi-collector inductively coupled plasma mass spectrometry (MC-ICP/MS).

PubMed

Elwaer, Nagmeddin; Hintelmann, Holger

2007-11-01

The analytical performance of five sample introduction systems, a cross flow nebulizer spray chamber, two different solvent desolvation systems, a multi-mode sample introduction system (MSIS), and a hydride generation (LI2) system were compared for the determination of Se isotope ratio measurements using multi-collector inductively coupled plasma mass spectrometry (MC-ICP/MS). The optimal operating parameters for obtaining the highest Se signal-to-noise (S/N) ratios and isotope ratio precision for each sample introduction were determined. The hydride generation (LI2) system was identified as the most suitable sample introduction method yielding maximum sensitivity and precision for Se isotope ratio measurement. It provided five times higher S/N ratios for all Se isotopes compared to the MSIS, 20 times the S/N ratios of both desolvation units, and 100 times the S/N ratios produced by the conventional spray chamber sample introduction method. The internal precision achieved for the (78)Se/(82)Se ratio at 100 ng mL(-1) Se with the spray chamber, two desolvation, MSIS, and the LI2 systems coupled to MC-ICP/MS was 150, 125, 114, 13, and 7 ppm, respectively. Instrument mass bias factors (K) were calculated using an exponential law correction function. Among the five studied sample introduction systems the LI2 showed the lowest mass bias of -0.0265 and the desolvation system showed the largest bias with -0.0321.

The role of the Standard Days Method in modern family planning services in developing countries.

PubMed

Lundgren, Rebecka I; Karra, Mihira V; Yam, Eileen A

2012-08-01

The mere availability of family planning (FP) services is not sufficient to improve reproductive health; services must also be of adequate quality. The introduction of new contraceptive methods is a means of improving quality of care. The Standard Days Method (SDM) is a new fertility-awareness-based contraceptive method that has been successfully added to reproductive health care services around the world. Framed by the Bruce-Jain quality-of-care paradigm, this paper describes how the introduction of SDM in developing country settings can improve the six elements of quality while contributing to the intrinsic variety of available methods. SDM meets the needs of women and couples who opt not to use other modern methods. SDM providers are sensitised to the potential of fertility-awareness-based contraception as an appropriate choice for these clients. SDM requires the involvement of both partners and thus offers a natural entry point for providers to further explore partner communication, intimate partner violence, condoms, and HIV/STIs. SDM introduction broadens the range of FP methods available to couples in developing countries. SDM counselling presents an opportunity for FP providers to discuss important interpersonal and reproductive health issues with potential users.

Diapers Full of?…?Pampered, Hugged, and "Luved" Babies: Teaching Ideological Criticism through Diapers

ERIC Educational Resources Information Center

Wells, Celeste C.

2016-01-01

Courses: Communication Criticism, Rhetorical Criticism, Introduction to Rhetoric, Introduction to Communication, Media Studies, and Persuasion courses. Objective: The aim of this activity is to introduce and explain the method of ideological criticism through commonplace advertising.

Sessions with Associated Abstracts by Day: Teaching Materials and Methods.

ERIC Educational Resources Information Center

Physiologist, 1984

1984-01-01

Presented are abstracts of five papers on teaching materials/methods presented at the 35th annual meeting of the American Physiological Society. Topic areas include expert system used as a teacher/consultant in hemostasis problems, computer assisted testing, and excitation/conduction properties of membranes as illustrated by the compound action…

Enumerating Small Sudoku Puzzles in a First Abstract Algebra Course

ERIC Educational Resources Information Center

Lorch, Crystal; Lorch, John

2008-01-01

Two methods are presented for counting small "essentially different" sudoku puzzles using elementary group theory: one method (due to Jarvis and Russell) uses Burnside's counting formula, while the other employs an invariant property of sudoku puzzles. Ideas are included for incorporating this material into an introductory abstract algebra course.…

Cross-scale modeling of surface temperature and tree seedling establishment inmountain landscapes

USGS Publications Warehouse

Dingman, John; Sweet, Lynn C.; McCullough, Ian M.; Davis, Frank W.; Flint, Alan L.; Franklin, Janet; Flint, Lorraine E.

2013-01-01

Abstract: Introduction: Estimating surface temperature from above-ground field measurements is important for understanding the complex landscape patterns of plant seedling survival and establishment, processes which occur at heights of only several centimeters. Currently, future climate models predict temperature at 2 m above ground, leaving ground-surface microclimate not well characterized. Methods: Using a network of field temperature sensors and climate models, a ground-surface temperature method was used to estimate microclimate variability of minimum and maximum temperature. Temperature lapse rates were derived from field temperature sensors and distributed across the landscape capturing differences in solar radiation and cold air drainages modeled at a 30-m spatial resolution. Results: The surface temperature estimation method used for this analysis successfully estimated minimum surface temperatures on north-facing, south-facing, valley, and ridgeline topographic settings, and when compared to measured temperatures yielded an R2 of 0.88, 0.80, 0.88, and 0.80, respectively. Maximum surface temperatures generally had slightly more spatial variability than minimum surface temperatures, resulting in R2 values of 0.86, 0.77, 0.72, and 0.79 for north-facing, south-facing, valley, and ridgeline topographic settings. Quasi-Poisson regressions predicting recruitment of Quercus kelloggii (black oak) seedlings from temperature variables were significantly improved using these estimates of surface temperature compared to air temperature modeled at 2 m. Conclusion: Predicting minimum and maximum ground-surface temperatures using a downscaled climate model coupled with temperature lapse rates estimated from field measurements provides a method for modeling temperature effects on plant recruitment. Such methods could be applied to improve projections of species’ range shifts under climate change. Areas of complex topography can provide intricate microclimates that may allow species to redistribute locally as climate changes.

Components that affect the Implementation of Health Services’ Strategic Purchasing: A Comprehensive Review of the Literature

PubMed Central

Bastani, Peivand; Samadbeik, Mahnaz; Kazemifard, Yalda

2016-01-01

Introduction Strategic purchasing is one of the mechanisms that can increase access, equity, and efficiency as well as the correct management of health resources. The aim of this study was to extract important and influential factors as necessary infrastructures to implement this method. Methods In this comprehensive literature review, 13 databases and search engines were searched from 2000 to 2015 by applying appropriate keywords. From a total of 1403 titles and after ensuring the validity of the study by the Clinical Appraisal Skills Program (CASP) tool, 18 articles that contained title, abstract, and associated text were used in the study, and their related information was analyzed and extracted using an extraction form and LitAssist software. Results The findings showed six categories of intervention have been effective in the strategic purchasing of all health interventions in different countries. These six categories were “The target group of users of the service” (demand side), “purchased interventions,” “providers and suppliers of interventions” (the supply side), “Methods and incentives” (payment method), “price,” and “Structure and organization.” Conclusion Although the necessity of performing strategic purchasing in the health sector or developing countries is an indisputable fact, it is of great importance to use the experiences of developed countries while considering the factors extracted from the study for implementing this method. In this regard, it is suggested that studies be performed that can lead to assessing the feasibility of strategic purchasing for health services in developing countries and also in Iran to help health policy makers in these countries. PMID:27382441

Estimated incidence of pertussis in people aged <50 years in the United States

PubMed Central

Chen, Chi-Chang; Balderston McGuiness, Catherine; Krishnarajah, Girishanthy; Blanchette, Christopher M.; Wang, Yuanyuan; Sun, Kainan; Buck, Philip O.

2016-01-01

ABSTRACT The introduction of pertussis vaccination in the United States (US) in the 1940s has greatly reduced its burden. However, the incidence of pertussis is difficult to quantify, as many cases are not laboratory-confirmed or reported, particularly in adults. This study estimated pertussis incidence in a commercially insured US population aged <50 years. Data were extracted from IMS' PharMetrics Plus claims database for patients with a diagnosis of pertussis or cough illness using International Classification of Diseases (ICD-9) codes, a commercial outpatient laboratory database for patients with a pertussis laboratory test, and the Centers for Disease Control influenza surveillance database. US national pertussis incidence was projected using 3 methods: (1) diagnosed pertussis, defined as a claim for pertussis (ICD-9 033.0, 033.9, 484.3) during 2008–2013; (2) based on proxy pertussis predictive logistic regression models; (3) using the fraction of cough illness (ICD-9 033.0, 033.9, 484.3, 786.2, 466.0, 466.1, 487.1) attributed to laboratory-confirmed pertussis, estimated by time series linear regression models. Method 1 gave a projected annual incidence of diagnosed pertussis of 9/100,000, which was highest in those aged <1 year. Method 2 gave an average annual projected incidence of 21/100,000. Method 3 gave an overall regression-estimated weighted annual incidence of pertussis of 649/100,000, approximately 58–93 times higher than method 1 depending on the year. These estimations, which are consistent with considerable underreporting of pertussis in people aged <50 years and provide further evidence that the majority of cases go undetected, especially with increasing age, may aid in the development of public health programs to reduce pertussis burden. PMID:27246119

The Impact of Mobile Health Interventions on Chronic Disease Outcomes in Developing Countries: A Systematic Review

PubMed Central

Lee, Allison G.; Willner, Jonathan M.; Jahangir, Eiman; Ciapponi, Agustín; Rubinstein, Adolfo

2014-01-01

Abstract Introduction: Rates of chronic diseases will continue to rise in developing countries unless effective and cost-effective interventions are implemented. This review aims to discuss the impact of mobile health (m-health) on chronic disease outcomes in low- and middle-income countries (LMIC). Materials and Methods: Systematic literature searches were performed using CENTRAL, MEDLINE, EMBASE, and LILACS databases and gray literature. Scientific literature was searched to identify controlled studies evaluating cell phone voice and text message interventions to address chronic diseases in adults in low- or middle-income countries. Outcomes measured included morbidity, mortality, hospitalization rates, behavioral or lifestyle changes, process of care improvements, clinical outcomes, costs, patient–provider satisfaction, compliance, and health-related quality of life (HRQoL). Results: From the 1,709 abstracts retrieved, 163 articles were selected for full text review, including 9 randomized controlled trials with 4,604 participants. Most of the studies addressed more than one outcome. Of the articles selected, six studied clinical outcomes, six studied processes of care, three examined healthcare costs, and two examined HRQoL. M-health positively impacted on chronic disease outcomes, improving attendance rates, clinical outcomes, and HRQoL, and was cost-effective. Conclusions: M-health is emerging as a promising tool to address access, coverage, and equity gaps in developing countries and low-resource settings. The results for m-health interventions showed a positive impact on chronic diseases in LMIC. However, a limiting factor of this review was the relatively small number of studies and patients enrolled, highlighting the need for more rigorous research in this area in developing countries. PMID:24205809

State of reporting of primary biomedical research: a scoping review protocol

PubMed Central

Mbuagbaw, Lawrence; Samaan, Zainab; Jin, Yanling; Nwosu, Ikunna; Levine, Mitchell A H; Adachi, Jonathan D; Thabane, Lehana

2017-01-01

Introduction Incomplete or inconsistent reporting remains a major concern in the biomedical literature. Incomplete or inconsistent reporting may yield the published findings unreliable, irreproducible or sometimes misleading. In this study based on evidence from systematic reviews and surveys that have evaluated the reporting issues in primary biomedical studies, we aim to conduct a scoping review with focuses on (1) the state-of-the-art extent of adherence to the emerging reporting guidelines in primary biomedical research, (2) the inconsistency between protocols or registrations and full reports and (3) the disagreement between abstracts and full-text articles. Methods and analyses We will use a comprehensive search strategy to retrieve all available and eligible systematic reviews and surveys in the literature. We will search the following electronic databases: Web of Science, Excerpta Medica Database (EMBASE), MEDLINE and Cumulative Index to Nursing and Allied Health Literature (CINAHL). Our outcomes are levels of adherence to reporting guidelines, levels of consistency between protocols or registrations and full reports and the agreement between abstracts and full reports, all of which will be expressed as percentages, quality scores or categorised rating (such as high, medium and low). No pooled analyses will be performed quantitatively given the heterogeneity of the included systematic reviews and surveys. Likewise, factors associated with improved completeness and consistency of reporting will be summarised qualitatively. The quality of the included systematic reviews will be evaluated using AMSTAR (a measurement tool to assess systematic reviews). Ethics and dissemination All findings will be published in peer-reviewed journals and relevant conferences. These results may advance our understanding of the extent of incomplete and inconsistent reporting, factors related to improved completeness and consistency of reporting and potential recommendations for various stakeholders in the biomedical community. PMID:28360252

Anorganic bovine-derived hydroxyapatite versus β-tricalcium phosphate in sinus augmentation. A comparative histomorphometric study.

PubMed

Kurkcu, Mehmet; Benlidayi, Mehmet Emre; Cam, Burcu; Sertdemir, Yasar

2012-05-22

Abstract AbstractIntroduction: The choice of augmentation material is a crucial factor in sinus augmentation surgery. Bovine-derived hydroxyapatite (BHA) and beta-tricalcium phosphate (β-TCP) have been used successfully in sinus augmentation procedures. Choosing one of these materials for sinus augmentation is still controversial. The aim of this clinical study was to compare the biological performance of the new BHA graft material and the well known synthetic β-TCP material in sinus augmentation procedure.Material and Methods: The study consisted of 23 patients (12 male and 11 female) who were either edentulous or partially edentulous in the posterior maxilla and required implant placement. A total of 23 two-step sinus grafting procedures were performed. BHA was used in 13 patients and β-TCP was used in 10 patients. After average of 6.5 months of healing bone biopsies were taken from the grafted areas. Undecalcified sections were prepared for histomorphometric analysis. Results: The mean new bone formation was 30.13±3.45% in BHA group and 21.09±2.86% in β-TCP group (p=0.001). The mean percentage of residual graft particle area was 31.88±6.05% and 34.05±3.01% for BHA group and β-TCP group, respectively (p=0.047). The mean percentage of soft tissue area was 37.99±5.92% in BHA group and 44.86±4.28% in β-TCP group (p=0.011).Conclusion: Both graft materials demonstrated successful biocompatibility and osteoconductivity in sinus augmentation procedure. However, BHA appears to be more efficient in osteoconduction when compared to β-TCP.

Gender inequalities in occupational health related to the unequal distribution of working and employment conditions: a systematic review

PubMed Central

2013-01-01

Introduction Gender inequalities exist in work life, but little is known about their presence in relation to factors examined in occupation health settings. The aim of this study was to identify and summarize the working and employment conditions described as determinants of gender inequalities in occupational health in studies related to occupational health published between 1999 and 2010. Methods A systematic literature review was undertaken of studies available in MEDLINE, EMBASE, Sociological Abstracts, LILACS, EconLit and CINAHL between 1999 and 2010. Epidemiologic studies were selected by applying a set of inclusion criteria to the title, abstract, and complete text. The quality of the studies was also assessed. Selected studies were qualitatively analysed, resulting in a compilation of all differences between women and men in the prevalence of exposure to working and employment conditions and work-related health problems as outcomes. Results Most of the 30 studies included were conducted in Europe (n=19) and had a cross-sectional design (n=24). The most common topic analysed was related to the exposure to work-related psychosocial hazards (n=8). Employed women had more job insecurity, lower control, worse contractual working conditions and poorer self-perceived physical and mental health than men did. Conversely, employed men had a higher degree of physically demanding work, lower support, higher levels of effort-reward imbalance, higher job status, were more exposed to noise and worked longer hours than women did. Conclusions This systematic review has identified a set of working and employment conditions as determinants of gender inequalities in occupational health from the occupational health literature. These results may be useful to policy makers seeking to reduce gender inequalities in occupational health, and to researchers wishing to analyse these determinants in greater depth. PMID:23915121

Evidence of pharmacological and non-pharmacological interventions for the management of dental fear in paediatric dentistry: a systematic review protocol

PubMed Central

Cianetti, Stefano; Paglia, Luigi; Gatto, Roberto; Montedori, Alessandro

2017-01-01

Introduction Several techniques have been proposed to manage dental fear/dental anxiety (DFA) in children and adolescents undergoing dental procedures. To our knowledge, no widely available compendium of therapies to manage DFA exists. We propose a study protocol to assess the evidence regarding pharmacological and non-pharmacological interventions to relieve dental anxiety in children and adolescents. Methods and analysis In our systematic review, we will include randomised trials, controlled clinical rials and systematic reviews (SRs) of trials that investigated the effects of pharmacological and non-pharmacological interventions to decrease dental anxiety in children and adolescents. We will search the Cochrane Database of Systematic Reviews, the Cochrane Database of Abstracts of Reviews of Effects=, the Cochrane Central Register of Controlled Trials, PubMed, PsycINFO, Cumulative Index to Nursing and Allied Health Literature and the Web of Science for relevant studies. Pairs of review authors will independently review titles, abstracts and full texts identified by the specific literature search and extract data using a standardised data extraction form. For each study, information will be extracted on the study report (eg, author, year of publication), the study design (eg, the methodology and, for SRs, the types and number of studies included), the population characteristics, the intervention(s), the outcome measures and the results. The quality of SRs will be assessed using the A Measurement Tool to Assess Reviews instrument, while the quality of the retrieved trials will be evaluated using the Cochrane Handbook for Systematic Reviews of Interventions criteria. Ethics and dissemination Approval from an ethics committee is not required, as no participants will be included. Results will be disseminated through a peer-reviewed publications and conference presentations. PMID:28821522

Scoping review protocol: education initiatives for medical psychiatry collaborative care

PubMed Central

Shen, Nelson; Sockalingam, Sanjeev; Abi Jaoude, Alexxa; Bailey, Sharon M; Bernier, Thérèse; Freeland, Alison; Hawa, Aceel; Hollenberg, Elisa; Woldemichael, Bethel; Wiljer, David

2017-01-01

Introduction The collaborative care model is an approach providing care to those with mental health and addictions disorders in the primary care setting. There is a robust evidence base demonstrating its clinical and cost-effectiveness in comparison with usual care; however, the transitioning to this new paradigm of care has been difficult. While there are efforts to train and prepare healthcare professionals, not much is known about the current state of collaborative care training programmes. The objective of this scoping review is to understand how widespread these collaborative care education initiatives are, how they are implemented and their impacts. Methods and analysis The scoping review methodology uses the established review methodology by Arksey and O’Malley. The search strategy was developed by a medical librarian and will be applied in eight different databases spanning multiple disciplines. A two-stage screening process consisting of a title and abstract scan and a full-text review will be used to determine the eligibility of articles. To be included, articles must report on an existing collaborative care education initiative for healthcare providers. All articles will be independently assessed for eligibility by pairs of reviewers, and all eligible articles will be abstracted and charted in duplicate using a standardised form. The extracted data will undergo a ‘narrative review’ or a descriptive analysis of the contextual or process-oriented data and simple quantitative analysis using descriptive statistics. Ethics and dissemination Research ethics approval is not required for this scoping review. The results of this scoping review will inform the development of a collaborative care training initiative emerging from the Medical Psychiatry Alliance, a four-institution philanthropic partnership in Ontario, Canada. The results will also be presented at relevant national and international conferences and published in a peer-reviewed journal. PMID:28871017

Mall Walking Program Environments, Features, and Participants: A Scoping Review

PubMed Central

Belza, Basia; Allen, Peg; Brolliar, Sarah; Brown, David R.; Cormier, Marc L.; Janicek, Sarah; Jones, Dina L.; King, Diane K.; Marquez, David X.; Rosenberg, Dori E.

2015-01-01

Introduction Walking is a preferred and recommended physical activity for middle-aged and older adults, but many barriers exist, including concerns about safety (ie, personal security), falling, and inclement weather. Mall walking programs may overcome these barriers. The purpose of this study was to summarize the evidence on the health-related value of mall walking and mall walking programs. Methods We conducted a scoping review of the literature to determine the features, environments, and benefits of mall walking programs using the RE-AIM framework (reach, effectiveness, adoption, implementation, and maintenance). The inclusion criteria were articles that involved adults aged 45 years or older who walked in indoor or outdoor shopping malls. Exclusion criteria were articles that used malls as laboratory settings or focused on the mechanics of walking. We included published research studies, dissertations, theses, conference abstracts, syntheses, nonresearch articles, theoretical papers, editorials, reports, policy briefs, standards and guidelines, and nonresearch conference abstracts and proposals. Websites and articles written in a language other than English were excluded. Results We located 254 articles on mall walking; 32 articles met our inclusion criteria. We found that malls provided safe, accessible, and affordable exercise environments for middle-aged and older adults. Programmatic features such as program leaders, blood pressure checks, and warm-up exercises facilitated participation. Individual benefits of mall walking programs included improvements in physical, social, and emotional well-being. Limited transportation to the mall was a barrier to participation. Conclusion We found the potential for mall walking programs to be implemented in various communities as a health promotion measure. However, the research on mall walking programs is limited and has weak study designs. More rigorous research is needed to define best practices for mall walking programs’ reach, effectiveness, adoption, implementation, and maintenance. PMID:26270743

Compliant flooring to prevent fall-related injuries: a scoping review protocol

PubMed Central

Lachance, Chantelle C; Jurkowski, Michal P; Dymarz, Ania C; Mackey, Dawn C

2016-01-01

Introduction Fall-related injuries can have serious consequences for older adults, including increased risk of dependence in daily activities and mortality. Compliant flooring is a passive intervention that may reduce the incidence and severity of fall-related injuries in healthcare settings, including acute and long-term care, but few sites have implemented compliant flooring, in part because synthesised evidence about key performance aspects has not been available. Methods and analysis We will conduct a scoping review to address the question: what is presented about the biomechanical efficacy, clinical effectiveness, cost-effectiveness, and workplace safety associated with compliant flooring systems that aim to prevent fall-related injuries? We will conduct a comprehensive and systematic literature search of academic databases (AgeLine, CINAHL, EBM Reviews, MEDLINE (Ovid), SportDiscus and Web of Science) and grey literature (clinical trial registries, theses/dissertations, abstracts/conference proceedings and relevant websites). 2 team members will independently screen records (first titles and abstracts, then full text) and extract data from included records. Numerical and narrative analyses will be presented by theme (biomechanical efficacy, clinical effectiveness, cost-effectiveness, workplace safety). Ethics and dissemination This scoping review responds to the information needs of healthcare decision-makers tasked with preventing fall-related injuries. This review will summarise evidence about compliant flooring as a potential intervention for preventing fall-related injuries in older adults and identify gaps in evidence and new avenues for research. Results will be especially useful in long-term care, but also applicable in acute care, assisted living and home care. We will disseminate the review's findings via open-access publications, conference presentations, a webinar, a Stakeholder Symposium and a Knowledge-to-Action Report. PMID:27531731

Effectiveness and meaningful use of paediatric surgical safety checklists and their implementation strategies: a systematic review with narrative synthesis

PubMed Central

Lagoo, Janaka; Lopushinsky, Steven R; Haynes, Alex B; Bain, Paul; Flageole, Helene; Skarsgard, Erik D; Brindle, Mary E

2017-01-01

Objective To examine the effectiveness and meaningful use of paediatric surgical safety checklists (SSCs) and their implementation strategies through a systematic review with narrative synthesis. Summary background data Since the launch of the WHO SSC, checklists have been integrated into surgical systems worldwide. Information is sparse on how SSCs have been integrated into the paediatric surgical environment. Methods A broad search strategy was created using Pubmed, Embase, CINAHL, Cochrane Central, Web of Science, Science Citation Index and Conference Proceedings Citation Index. Abstracts and full texts were screened independently, in duplicate for inclusion. Extracted study characteristic and outcomes generated themes explored through subgroup analyses and idea webbing. Results 1826 of 1921 studies were excluded after title and abstract review (kappa 0.77) and 47 after full-text review (kappa 0.86). 20 studies were of sufficient quality for narrative synthesis. Clinical outcomes were not affected by SSC introduction in studies without implementation strategies. A comprehensive SSC implementation strategy in developing countries demonstrated improved outcomes in high-risk surgeries. Narrative synthesis suggests that meaningful compliance is inconsistently measured and rarely achieved. Strategies involving feedback improved compliance. Stakeholder-developed implementation strategies, including team-based education, achieved greater acceptance. Three studies suggest that parental involvement in the SSC is valued by parents, nurses and physicians and may improve patient safety. Conclusions A SSC implementation strategy focused on paediatric patients and their families can achieve high acceptability and good compliance. SSCs’ role in improving measures of paediatric surgical outcome is not well established, but they may be effective when used within a comprehensive implementation strategy especially for high-risk patients in low-resource settings. PMID:29042377

V/STOL Aerodynamics

DTIC Science & Technology

1974-10-01

jet exhaust, m (ft) Ro radius of engine exhaust, m (ft) 1. INTRODUCTION free deg S wing area, m2 (ft2) t time, see T Thrust, N (lb) u...dimensional potential flow method to lift prediction for a wing with internally blown flaps is described. INTRODUCTION The objectives of this paper are...twofold. The first is to provide an introduction to this session on research into the aerodynamics of powered high lift systems. This will be

Foundation Analysis East Coast Air Combat Maneuvering Range Offshore Kitty Hawk, North Carolina.

DTIC Science & Technology

1976-09-01

1976 86 2 3 025 TABLE OF CONTENTS SECTION TITLE PAGE 1.0 INTRODUCTION 1.1 Introduction 1.01 1.2 Methods of Analysis 1.01 1.3 Personnel Resumes 1.02...piling into the desired penetration. 1.2 METHODS OF ANALYSIS The method employed to perform the computation of pipe pile capacity curves, as presented...AD-A163 522 FOUNDATION ANALYSIS EAST COAST AIR COMBAT NANsUVERING 14S RANGE OFFSHORE KITT.. CU) CREST ENGINEERING INC TULSA OK SEP 76 27-M7-97 CNES

Development of a Research Participants’ Perception Survey to Improve Clinical Research

PubMed Central

Yessis, Jennifer L.; Kost, Rhonda G.; Lee, Laura M.; Coller, Barry S.; Henderson, David K.

2012-01-01

Abstract Introduction: Clinical research participants’ perceptions regarding their experiences during research protocols provide outcome‐based insights into the effectiveness of efforts to protect rights and safety, and opportunities to enhance participants’ clinical research experiences. Use of validated surveys measuring patient‐centered outcomes is standard in hospitals, yet no instruments exist to assess outcomes of clinical research processes. Methods: We derived survey questions from data obtained from focus groups comprised of research participants and professionals. We assessed the survey for face/content validity, and privacy/confidentiality protections and fielded it to research participants at 15 centers. We conducted analyses of response rates, sample characteristics, and psychometrics, including survey and item completion and analysis, internal consistency, item internal consistency, criterion‐related validity, and item usefulness. Responses were tested for fit into existing patient‐centered dimensions of care and new clinical research dimensions using Cronbach's alpha coefficient. Results: Surveys were mailed to 18,890 individuals; 4,961 were returned (29%). Survey completion was 89% overall; completion rates exceeded 90% for 88 of 93 evaluable items. Questions fit into three dimensions of patient‐centered care and two novel clinical research dimensions (Cronbach's alpha for dimensions: 0.69–0.85). Conclusions: The validated survey offers a new method for assessing and improving outcomes of clinical research processes. Clin Trans Sci 2012; Volume 5: 452–460 PMID:23253666

Generation of Transgenic Pigs by Cytoplasmic Injection of piggyBac Transposase-Based pmGENIE-3 Plasmids1

PubMed Central

Li, Zicong; Zeng, Fang; Meng, Fanming; Xu, Zhiqian; Zhang, Xianwei; Huang, Xiaoling; Tang, Fei; Gao, Wenchao; Shi, Junsong; He, Xiaoyan; Liu, Dewu; Wang, Chong; Urschitz, Johann; Moisyadi, Stefan; Wu, Zhenfang

2014-01-01

ABSTRACT The process of transgenesis involves the introduction of a foreign gene, the transgene, into the genome of an animal. Gene transfer by pronuclear microinjection (PNI) is the predominant method used to produce transgenic animals. However, this technique does not always result in germline transgenic offspring and has a low success rate for livestock. Alternate approaches, such as somatic cell nuclear transfer using transgenic fibroblasts, do not show an increase in efficiency compared to PNI, while viral-based transgenesis is hampered by issues regarding transgene size and biosafety considerations. We have recently described highly successful transgenesis experiments with mice using a piggyBac transposase-based vector, pmhyGENIE-3. This construct, a single and self-inactivating plasmid, contains all the transpositional elements necessary for successful gene transfer. In this series of experiments, our laboratories have implemented cytoplasmic injection (CTI) of pmGENIE-3 for transgene delivery into in vivo-fertilized pig zygotes. More than 8.00% of the injected embryos developed into transgenic animals containing monogenic and often single transgenes in their genome. However, the CTI technique was unsuccessful during the injection of in vitro-fertilized pig zygotes. In summary, here we have described a method that is not only easy to implement, but also demonstrated the highest efficiency rate for nonviral livestock transgenesis. PMID:24671876

Brazilian medicinal plants to treat upper respiratory tract and bronchial illness: systematic review and meta-analyses—study protocol

PubMed Central

Lopes, Luciane C; Silva, Maria Carolina O; Motta, Cristiane Bergamashi; Macho Quirós, Antonio; Biavatti, Maique Weber; de Oliveira, Jardel Corrêa; Guyatt, Gordon

2014-01-01

Introduction Respiratory illness, often associated with cough and sputum, is frequent. In Brazil, herbal medicines are often recommended as a first-line treatment for respiratory illness. There exists uncertainty regarding the effectiveness of these treatments. No systematic review has evaluated Brazilian medicinal plants (BMP) to treat upper respiratory tract and bronchial illness (URTI). Methods and analysis We will conduct a systematic review and, if appropriate, a series of meta-analyses evaluating the safety and effectiveness of BMP for URTI. Eligible randomised controlled trials and observational studies will enrol adult or paediatric patients presenting with URTI treated by BMP approved by the Brazilian Health Surveillance Agency compared with placebo, no treatment or an alternative therapy. Our search will include the Cochrane Central Register of Controlled Trials (CENTRAL), which contains the Cochrane Acute Respiratory Illness Group's Specialized Register; MEDLINE; EMBASE; CINAHL (Cumulative Index to Nursing and Allied Health Literature); Web of Science; AMED; LILACS; CAB abstracts; clinical trial.gov; the WHO Trial Register and the Brazilian thesis database (CAPES) without any language restrictions. Outcomes of interest are time to resolution of clinical symptoms and/or signs (cough, sputum production or activity limitations), severity of symptoms prior to resolution and major/minor adverse events. Teams of reviewers will, independently and in duplicate, screen titles and abstracts and the complete full text to determine eligibility. For eligible studies, reviewers will perform data abstraction and assess risk of bias of eligible trials. When appropriate, we will conduct meta-analyses. We will also assess the quality of body of evidence (confidence in estimates of effect) for each of the outcomes using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. Ethics and dissemination The systematic review will be published in a peer-reviewed journal. Brief reports of review findings will be disseminated directly to appropriate audiences via email and other modes of communication. The review will guide healthcare practice and policy in Brazil. Trial registration number Prospero CRD42014007057. PMID:25056973

Effect of visual target blurring on accommodation under distance viewing

NASA Astrophysics Data System (ADS)

Iwata, Yo; Handa, Tomoya; Ishikawa, Hitoshi

2018-04-01

Abstract Purpose To examine the effect of visual target blurring on accommodation. Methods We evaluated the objective refraction values when the visual target (asterisk; 8°) was changed from the state without Gaussian blur (15 s) to the state with Gaussian blur adapted [0(without blur) → 10, 0 → 50, 0 → 100: 15 s each]. Results In Gaussian blur 10, when blurring of the target occurred, refraction value did not change significantly. In Gaussian blur 50 and 100, when blurring of the target occurred, the refraction value became significantly myopic. Conclusion Blurring of the distant visual target results in intervention of accommodation.

A Mathematical Model for Railway Control Systems

NASA Technical Reports Server (NTRS)

Hoover, D. N.

1996-01-01

We present a general method for modeling safety aspects of railway control systems. Using our modeling method, one can progressively refine an abstract railway safety model, sucessively adding layers of detail about how a real system actually operates, while maintaining a safety property that refines the original abstract safety property. This method supports a top-down approach to specification of railway control systems and to proof of a variety of safety-related properties. We demonstrate our method by proving safety of the classical block control system.

Course 8: Biological Physics in Silico

NASA Astrophysics Data System (ADS)

Austin, R. H.

1 Why micro/nanofabrication? Lecture 1a: Hydrodynamic Transport 1 Introduction: The need to control flows in 2 1/2 D 2 Somewhat simple hydrodynamics in 2 1/2 D 3 The N-port injector idea 4 Conclusion Lecture 1b: Dielectrophoresis and Microfabrication 1 Introduction 2 Methods 3 Results 4 Data and analysis 5 Origin of the low frequency dielectrophoretic force in DNA 6 Conclusion Lecture 2a: Hex Arrays 1 Introduction 2 Experimental approach 3 Conclusions Lecture 2b: The DNA Prism 1 Introduction 2 Design 3 Results 4 Conclusions Lecture 2c: Bigger is Better in Rachets 1 The problems with insulators in rachets 2 An experimental test 3 Conclusions Lecture 3: Going After Epigenetics 1 Introduction 2 The nearfield scanner 3 The chip 4 Experiments with molecules 5 Conclusions Lecture 4: Fractionating Cells 1 Introduction 2 Blood specifics 3 Magnetic separation 4 Microfabrication 5 Magnetic field gradients 6 Device interface 7 A preliminary blood cell run 8 Conclusions Lecture 5: Protein Folding on a Chip 1 Introduction 2 Technology 3 Experiments 4 Conclusions

Overcoming the Challenges of Unstructured Data in Multi-site, Electronic Medical Record-based Abstraction

PubMed Central

Polnaszek, Brock; Gilmore-Bykovskyi, Andrea; Hovanes, Melissa; Roiland, Rachel; Ferguson, Patrick; Brown, Roger; Kind, Amy JH

2014-01-01

Background Unstructured data encountered during retrospective electronic medical record (EMR) abstraction has routinely been identified as challenging to reliably abstract, as this data is often recorded as free text, without limitations to format or structure. There is increased interest in reliably abstracting this type of data given its prominent role in care coordination and communication, yet limited methodological guidance exists. Objective As standard abstraction approaches resulted in sub-standard data reliability for unstructured data elements collected as part of a multi-site, retrospective EMR study of hospital discharge communication quality, our goal was to develop, apply and examine the utility of a phase-based approach to reliably abstract unstructured data. This approach is examined using the specific example of discharge communication for warfarin management. Research Design We adopted a “fit-for-use” framework to guide the development and evaluation of abstraction methods using a four step, phase-based approach including (1) team building, (2) identification of challenges, (3) adaptation of abstraction methods, and (4) systematic data quality monitoring. Measures Unstructured data elements were the focus of this study, including elements communicating steps in warfarin management (e.g., warfarin initiation) and medical follow-up (e.g., timeframe for follow-up). Results After implementation of the phase-based approach, inter-rater reliability for all unstructured data elements demonstrated kappas of ≥ 0.89 -- an average increase of + 0.25 for each unstructured data element. Conclusions As compared to standard abstraction methodologies, this phase-based approach was more time intensive, but did markedly increase abstraction reliability for unstructured data elements within multi-site EMR documentation. PMID:27624585

How-To-Do-It. A Beetle, a Bur, and the Potato: An Introduction to Ecology.

ERIC Educational Resources Information Center

Jantzen, Paul G.

1983-01-01

Describes how the interrelation of the potato beetle, the buffalo-bur, and the potato is used as an introduction to ecology. Methods of controlling the beetle and ecological principles illustrated in the interrelationship are discussed. (JN)

Publication rates of abstracts presented at the Association of Chiropractic Colleges Educational Conference/Research Agenda Conference from 2002 to 2008

PubMed Central

Bakkum, Barclay W.; Chapman, Cynthia; Johnson, Claire

2014-01-01

Objective The purposes of this study were to investigate the overall publication rates of presentations at the Association of Chiropractic Colleges Educational Conference/Research Agenda Conference (ACC/RAC) meetings (2002–2008), differences in the publication rates of platform vs poster presentations, and the consistency of the meeting abstract compared to the full-length journal article. Methods Abstracts were obtained from proceedings published in the Journal of Chiropractic Education. Literature searches using PubMed and the Index to the Chiropractic Literature (ICL) were performed to locate peer-reviewed journal articles based upon those abstracts. Whether the article was based upon a poster or platform presentation, and the congruence of the information in the abstract and article were recorded. Results We identified 776 proceeding abstracts, 249 of which eventually were published between 2002 and 2012. The overall publication rate was 32.2%. A total of 42.7% of platform presentations eventually were published vs 20.3% of posters. Congruency showed that 43.2% had the same title as the meeting abstract, 59.7% had the same authorship, and 88.8% had the same methods. Conclusion Publication rates of abstracts from spine and orthopedic surgery national meetings range from 34% to 59%. The ACC/RAC meetings have similar publication rates. More platform than poster presentations reach full publication. The congruency of ACC/RAC abstracts to published articles is higher than national meetings in other fields. PMID:24295363

Developing a research agenda for patient safety in primary care. Background, aims and output of the LINNEAUS collaboration on patient safety in primary care

PubMed Central

Esmail, Aneez; Valderas, Jose M.; Verstappen, Wim; Godycki-Cwirko, Maciek; Wensing, Michel

2015-01-01

ABSTRACT This paper is an introduction to a supplement to The European Journal of General Practice, bringing together a body of research focusing on the issue of patient safety in relation to primary care. The supplement represents the outputs of the LINNEAUS collaboration on patient safety in primary care, which was a four-year (2009–2013) coordination and support action funded under the Framework 7 programme by the European Union. Being a coordination and support action, its aim was not to undertake new research, but to build capacity through engaging primary care researchers and practitioners in identifying some of the key challenges in this area and developing consensus statements, which will be an essential part in developing a future research agenda. This introductory article describes the aims of the LINNEAUS collaboration, provides a brief summary of the reasons to focus on patient safety in primary care, the epidemiological and policy considerations, and an introduction to the papers included in the supplement. PMID:26339828

Bayesian hypothesis testing for human threat conditioning research: an introduction and the condir R package

PubMed Central

Krypotos, Angelos-Miltiadis; Klugkist, Irene; Engelhard, Iris M.

2017-01-01

ABSTRACT Threat conditioning procedures have allowed the experimental investigation of the pathogenesis of Post-Traumatic Stress Disorder. The findings of these procedures have also provided stable foundations for the development of relevant intervention programs (e.g. exposure therapy). Statistical inference of threat conditioning procedures is commonly based on p-values and Null Hypothesis Significance Testing (NHST). Nowadays, however, there is a growing concern about this statistical approach, as many scientists point to the various limitations of p-values and NHST. As an alternative, the use of Bayes factors and Bayesian hypothesis testing has been suggested. In this article, we apply this statistical approach to threat conditioning data. In order to enable the easy computation of Bayes factors for threat conditioning data we present a new R package named condir, which can be used either via the R console or via a Shiny application. This article provides both a non-technical introduction to Bayesian analysis for researchers using the threat conditioning paradigm, and the necessary tools for computing Bayes factors easily. PMID:29038683

10 Years of Car-2-X Communication - a Success Story?

NASA Astrophysics Data System (ADS)

Wischhof, Lars; Ebner, André

2012-05-01

For more than ten years, car-2-x communication has been a major topic of research in the scientific community and an important development focus for the automotive industry. First, this article takes a retrospective look at the evolution of car-2-x and the two different communication paradigms: decentralized car-2-car communication and centralized cellular solutions. Afterwards, a comparison of their technical advantages and limitations is presented, respectively. The result shows that in order to implement safety-relevant applications, car-2-car communication has strong advantages compared to cellular technologies but requires high market penetration. However, its introduction solely for safety applications is difficult since the required penetration will not be achieved until several years after initial deployment. Therefore, car-2-car communication must provide a benefit to the customer, even in the phase of market introduction. For this purpose, the article outlines an approach called SODAD (Segment-Oriented Data Abstraction and Dissemination). It offers a possibility to introduce decentralized vehicular applications with early customer benefit, in order to enable safety applications based on car-2-car communication on a long term.

Effect of introduction of electronic patient reporting on the duration of ambulance calls.

PubMed

Kuisma, Markku; Väyrynen, Taneli; Hiltunen, Tuomas; Porthan, Kari; Aaltonen, Janne

2009-10-01

We examined the effect of the change from paper records to the electronic patient records (EPRs) on ambulance call duration. We retrieved call duration times 6 months before (group 1) and 6 months after (group 2) the introduction of EPR. Subgroup analysis of group 2 was fulfilled depending whether the calls were made during the first or last 3 months after EPR introduction. We analyzed 37 599 ambulance calls (17 950 were in group 1 and 19 649 were in group 2). The median call duration in group 1 was 48 minutes and in group 2 was 49 minutes (P = .008). In group 2, call duration was longer during the first 3 months after EPR introduction. In multiple linear regression analysis, urgency category (P < .0001), unit level (P < .0001), and transportation decision (P < .0001) influenced the call duration. The documentation method was not a significant factor. Electronic patient record system can be implemented in an urban ambulance service in such a way that documentation method does not become a significant factor in determining call duration in the long run. Temporary performance drop during the first 3 months after introduction was noticed, reflecting adaptation process to a new way of working.

Improved Ant Colony Clustering Algorithm and Its Performance Study

PubMed Central

Gao, Wei

2016-01-01

Clustering analysis is used in many disciplines and applications; it is an important tool that descriptively identifies homogeneous groups of objects based on attribute values. The ant colony clustering algorithm is a swarm-intelligent method used for clustering problems that is inspired by the behavior of ant colonies that cluster their corpses and sort their larvae. A new abstraction ant colony clustering algorithm using a data combination mechanism is proposed to improve the computational efficiency and accuracy of the ant colony clustering algorithm. The abstraction ant colony clustering algorithm is used to cluster benchmark problems, and its performance is compared with the ant colony clustering algorithm and other methods used in existing literature. Based on similar computational difficulties and complexities, the results show that the abstraction ant colony clustering algorithm produces results that are not only more accurate but also more efficiently determined than the ant colony clustering algorithm and the other methods. Thus, the abstraction ant colony clustering algorithm can be used for efficient multivariate data clustering. PMID:26839533

Beyond the Core: The Hot Topic(al) Alternative to the Survey-Based Introduction to Sociology Course.

PubMed

Schwartz, Michael; Smith, R Tyson

2010-10-01

In the following paper we argue that the conventional "Introduction to Sociology" survey course should be restructured because such courses try to survey an unsurveyable body of knowledge and they do not teach the application of sociological research. The conventional intro course should be replaced with an intro course that surveys the types of social dynamics that sociologists typically research and the methods they use to do so. We propose a semester-long intro course with four case study learning-units that are chosen for their coverage of the underlying sociological dynamics, methods, and core concepts. We contend that case study learning-units which concentrate on topical issues and core sociological concepts are better suited for an introduction course.

USSR and Eastern Europe Scientific Abstracts, Materials Science and Metallurgy, Number 45

DTIC Science & Technology

1977-05-11

constants VQ and q. The values of the critical stress intensity factor produced by the authors by their indirect method are compared with...and TEREKHOV, A. N., Moscow Institute of Steel and Alloys [Russian abstract provided by the source] [Text] The method of high-temperature...their melting point. References 9; all Russian. USSR ’ UDC 539𔃽 IMPROVING THE PRECISION OF THE ACOUSTIC METHOD OF STRESS DETERMINATION Kiev

New Active Remote-sensing Capabilities: Laser Ablation Spectrometer and Lidar Atmospheric Species Profile Measurements

NASA Technical Reports Server (NTRS)

DeYoung, R. J.; Bergstralh, J. T.

2005-01-01

Introduction: With the anticipated development of high-capacity fission power and electric propulsion for deep-space missions, it will become possible to propose experiments that demand higher power than current technologies (e.g. radioisotope power sources) provide. Jupiter Icy Moons Orbiter (JIMO), the first mission in the Project Prometheus program, will explore the icy moons of Jupiter with a suite of high-capability experiments that take advantage of the high power levels (and indirectly, the high data rates) that fission power affords. This abstract describes two high-capability active-remote-sensing experiments that will be logical candidates for subsequent Prometheus-class missions.

Evaluation of Biomarkers Predictive of Benefit from the PD-1 Inhibitor MK-3475 in Patients with Non-Small Cell Lung Cancer and Brain Metastases

DTIC Science & Technology

2017-07-01

Unlimited 13. SUPPLEMENTARY NOTES 14. ABSTRACT Immunotherapies inhibiting the Programmed Death -1 (PD-1) axis can result in dramatic responses and durable...9. Appendices……………………………………………………………14 4 1. INTRODUCTION: Lung cancer is the leading cause of cancer death in the United States, resulting in more...than 160,000 deaths each year. The majority of patients with lung cancer have non-small cell lung cancer (NSCLC) and present with disease at an

Medical hyperspectral imaging: a review

PubMed Central

Lu, Guolan; Fei, Baowei

2014-01-01

Abstract. Hyperspectral imaging (HSI) is an emerging imaging modality for medical applications, especially in disease diagnosis and image-guided surgery. HSI acquires a three-dimensional dataset called hypercube, with two spatial dimensions and one spectral dimension. Spatially resolved spectral imaging obtained by HSI provides diagnostic information about the tissue physiology, morphology, and composition. This review paper presents an overview of the literature on medical hyperspectral imaging technology and its applications. The aim of the survey is threefold: an introduction for those new to the field, an overview for those working in the field, and a reference for those searching for literature on a specific application. PMID:24441941

P16.30 4th ventricle glioblastoma

PubMed Central

Unal, E.; Isik, S.; Gurbuz, M.; Kilic, K.

2017-01-01

Abstract Introduction: We present the 2nd case ever known in English literature describing a glioblastoma of the fourth ventricle originating from cerebellar peduncle. CASE DESCIPTION: A 66 years old woman was admitted to hospital with dizziness and nausea for four months. An MRI scan showed fourth ventricle mass. First impression was an ependymoma due to MRI scan characteristics. Results: A surgery was performed and histopathology revealed Grade IV glial tumor. Radiotherapy was done. CONCLUSION: This report suggests that GBM can mimic every tumor in the CNS. Surgery is the best option for these tumors not only for aggressive behaviour of glioblastoma but also to prevent hydrocephalus and associated symptoms.

A Proposed Probabilistic Extension of the Halpern and Pearl Definition of ‘Actual Cause’

PubMed Central

2017-01-01

ABSTRACT Joseph Halpern and Judea Pearl ([2005]) draw upon structural equation models to develop an attractive analysis of ‘actual cause’. Their analysis is designed for the case of deterministic causation. I show that their account can be naturally extended to provide an elegant treatment of probabilistic causation. 1Introduction2Preemption3Structural Equation Models4The Halpern and Pearl Definition of ‘Actual Cause’5Preemption Again6The Probabilistic Case7Probabilistic Causal Models8A Proposed Probabilistic Extension of Halpern and Pearl’s Definition9Twardy and Korb’s Account10Probabilistic Fizzling11Conclusion PMID:29593362

Comparison of Two Mnemonic Encoding Strategies on Children's Recognition and Recall of Abstract Prose Information.

ERIC Educational Resources Information Center

Shriberg, Linda K.

As an extension of an earlier investigation that examined the effects of mnemonic strategy application on children's memory for abstract prose passages, a study compared the benefits accrued by students taught two different variations of the mnemonic keyword method for learning abstract prose information, via tasks of associative recognition and…

Construction of High School Students' Abstraction Levels in Understanding the Concept of Quadrilaterals

ERIC Educational Resources Information Center

Budiarto, Mega Teguh; Khabibah, Siti; Setianingsih, Rini

2017-01-01

The purpose of this study was to examine the abstraction thinking or the vertical reorganization activity of mathematical concepts of high school students while taking account of the abstraction that was constructed earlier, and the socio-cultural background. This study was qualitative in nature with task-based interviews as the method of…