Uniparental genetic heritage of belarusians: encounter of rare middle eastern matrilineages with a central European mitochondrial DNA pool.

PubMed

Kushniarevich, Alena; Sivitskaya, Larysa; Danilenko, Nina; Novogrodskii, Tadeush; Tsybovsky, Iosif; Kiseleva, Anna; Kotova, Svetlana; Chaubey, Gyaneshwer; Metspalu, Ene; Sahakyan, Hovhannes; Bahmanimehr, Ardeshir; Reidla, Maere; Rootsi, Siiri; Parik, Jüri; Reisberg, Tuuli; Achilli, Alessandro; Hooshiar Kashani, Baharak; Gandini, Francesca; Olivieri, Anna; Behar, Doron M; Torroni, Antonio; Davydenko, Oleg; Villems, Richard

2013-01-01

Ethnic Belarusians make up more than 80% of the nine and half million people inhabiting the Republic of Belarus. Belarusians together with Ukrainians and Russians represent the East Slavic linguistic group, largest both in numbers and territory, inhabiting East Europe alongside Baltic-, Finno-Permic- and Turkic-speaking people. Till date, only a limited number of low resolution genetic studies have been performed on this population. Therefore, with the phylogeographic analysis of 565 Y-chromosomes and 267 mitochondrial DNAs from six well covered geographic sub-regions of Belarus we strove to complement the existing genetic profile of eastern Europeans. Our results reveal that around 80% of the paternal Belarusian gene pool is composed of R1a, I2a and N1c Y-chromosome haplogroups - a profile which is very similar to the two other eastern European populations - Ukrainians and Russians. The maternal Belarusian gene pool encompasses a full range of West Eurasian haplogroups and agrees well with the genetic structure of central-east European populations. Our data attest that latitudinal gradients characterize the variation of the uniparentally transmitted gene pools of modern Belarusians. In particular, the Y-chromosome reflects movements of people in central-east Europe, starting probably as early as the beginning of the Holocene. Furthermore, the matrilineal legacy of Belarusians retains two rare mitochondrial DNA haplogroups, N1a3 and N3, whose phylogeographies were explored in detail after de novo sequencing of 20 and 13 complete mitogenomes, respectively, from all over Eurasia. Our phylogeographic analyses reveal that two mitochondrial DNA lineages, N3 and N1a3, both of Middle Eastern origin, might mark distinct events of matrilineal gene flow to Europe: during the mid-Holocene period and around the Pleistocene-Holocene transition, respectively.

[Franz Josef Kallmann (1897-1965) and the transfer of psychiatric-genetic scientific concepts from national socialist Germany to the U.S.A].

PubMed

Cottebrune, Anne

2009-01-01

The founding of the German Research Institute for Psychiatry and its Genealogic-Demographic Department (Genealogisch-Demographische Abteilung; GDA) in 1918 gave the world the first institutional platform for the field of psychiatric genetics. The years between the two World Wars saw the GDA grow in importance with much international respect. The close collaboration between the GDA's protagonist Ernst Rüdin and the National Socialist regime was certainly not an inhibiting factor for the worldwide recognition of the eugenic research conducted in Munich. Around the mid-1930s, the German psychiatrist émigré Franz Josef Kallmann brought the field of study which had been put into practice in Munich to the United States. He fought an uphill battle to be accepted by the North American scientific community, but finally he was able to establish himself as the main researcher in the field of psychiatric genetics. Interestingly enough, the fact that his kind of research had been heavily supported by the National Socialist regime was not a barrier to his acceptance. The fact that it took him a long time to establish the field of eugenics in the U.S.A. is better explained by the psychoanalytic research methods at the time, which gave hereditary transmission short shrift. At the New York State Psychiatric Institute he was able to continue his research, including the examination of race-hygienic motifs, where he designed a research program that was directly based on concepts and methods from Ernst Rüdin's team of researchers in Munich. The only deviation from the original research was in terms of the use of eugenic prophylaxis where he aligned his research in the context of North American democracy in the post-war era. However, the eugenic goal of elimination of certain categories of peoples remained unchanged.

Uniparental Genetic Heritage of Belarusians: Encounter of Rare Middle Eastern Matrilineages with a Central European Mitochondrial DNA Pool

PubMed Central

Kushniarevich, Alena; Sivitskaya, Larysa; Danilenko, Nina; Novogrodskii, Tadeush; Tsybovsky, Iosif; Kiseleva, Anna; Kotova, Svetlana; Chaubey, Gyaneshwer; Metspalu, Ene; Sahakyan, Hovhannes; Bahmanimehr, Ardeshir; Reidla, Maere; Rootsi, Siiri; Parik, Jüri; Reisberg, Tuuli; Achilli, Alessandro; Hooshiar Kashani, Baharak; Gandini, Francesca; Olivieri, Anna; Behar, Doron M.; Torroni, Antonio; Davydenko, Oleg; Villems, Richard

2013-01-01

Ethnic Belarusians make up more than 80% of the nine and half million people inhabiting the Republic of Belarus. Belarusians together with Ukrainians and Russians represent the East Slavic linguistic group, largest both in numbers and territory, inhabiting East Europe alongside Baltic-, Finno-Permic- and Turkic-speaking people. Till date, only a limited number of low resolution genetic studies have been performed on this population. Therefore, with the phylogeographic analysis of 565 Y-chromosomes and 267 mitochondrial DNAs from six well covered geographic sub-regions of Belarus we strove to complement the existing genetic profile of eastern Europeans. Our results reveal that around 80% of the paternal Belarusian gene pool is composed of R1a, I2a and N1c Y-chromosome haplogroups – a profile which is very similar to the two other eastern European populations – Ukrainians and Russians. The maternal Belarusian gene pool encompasses a full range of West Eurasian haplogroups and agrees well with the genetic structure of central-east European populations. Our data attest that latitudinal gradients characterize the variation of the uniparentally transmitted gene pools of modern Belarusians. In particular, the Y-chromosome reflects movements of people in central-east Europe, starting probably as early as the beginning of the Holocene. Furthermore, the matrilineal legacy of Belarusians retains two rare mitochondrial DNA haplogroups, N1a3 and N3, whose phylogeographies were explored in detail after de novo sequencing of 20 and 13 complete mitogenomes, respectively, from all over Eurasia. Our phylogeographic analyses reveal that two mitochondrial DNA lineages, N3 and N1a3, both of Middle Eastern origin, might mark distinct events of matrilineal gene flow to Europe: during the mid-Holocene period and around the Pleistocene-Holocene transition, respectively. PMID:23785503

Tufa and travertine of the Lesser Caucasus: a light on the Quaternary palaeoenvironment of the Circumcaspian regions

NASA Astrophysics Data System (ADS)

Ollivier, V.; Roiron, P.; Nahapetyan, S.; Joannin, S.; Chataigner, C.

2012-04-01

In the course of the International Associated Laboratory HEMHA (Humans and Environment in Mountainous Habitats : the case of Armenia), the French Foreign Affair Ministry Caucasus Mission (CNRS-UMR 5133 Archéorient, Lyon University) and the French-German research program Ancient Kura (CNRS-UMR 7192 PrOCauLAC, Paris, France, Deutsches Archäologisches Institut, Eurasien-Abteilung, Berlin, Germany with ANR-CNRS and DFG funding) numerous sites of the Lesser Caucasus territory are under geomorphological, palaeoenvironmental and archaeological investigations. Through comparisons between the tufa/travertine system and the detrital formation morphosedimentary evolution, one of our research interests is to define the Late Quaternary landscape mutations as well as the origin and rhythmicity of the major morphogenic trends reversals. The impacts of the environmental changes highlighted on the human occupation modes are also debated. A total of 14 travertine and tufa formations were studied (8 Pleistocene and 6 Postglacial formations) on a Northwest-Southeast transect of more than 300 km across the Lesser Caucasus. Each of these carbonated system development are correlated with high global relative sea levels and interstadial climates on a range between the Marine Isotopic Stage 11 and 1 (ca. 335 to 1.5 Ky BP). The absolute chronology is constrained by a series of U/Th and 14C dating. A total of 24 dating was performed (6 radiocarbon and 18 U/Th datings), allowing a high quality overview of the travertinization process over the time at a regional scale. Jointly with the measurement of the late Quaternary interglacial series impact on the tufas development in the Caucasus, the geomorphological position of some travertinous formations and their absolute dating gives some clues about the neotectonic evolution of the studied valleys. In some area, the uplift rate has been determined (ca. 8 mm/year) and discretized from the alluvial incision signal. The analysis of the carbonated deposits (faciological determinations, palaeobotanical and palynological identifications of leave imprints and pollens), which are the expression of specific climatic conditions, and the comparative approach with the general morphosedimentary evolution, give a complete reading grid of the regional landscape mutation expressions and origins (Caspian Sea eustatism or exclusive climatic impact), necessary to understand the magnitude of the changes and their influence on the Circumcaspian societies.

Budapest: A Random Walk in Science and Culture

NASA Astrophysics Data System (ADS)

Kovács, László

Hungary forms a linguistic island in Europe among the Germanic and Slavic nations. Both ethnically and linguistically, Hungarians are of Finno-Ugric origin. Millennia ago their ancient home was somewhere in the region of the Kama river near the Ural mountains.2 The conquest of the region around the Danube river occurred at the end of the 9th century. Between 12 BC and 433 AD the Romans dwelled in the Carpathian basin.The capital of Provincia Pannonia was Aquincum, which is now Óbuda, a part of Budapest. Aquincum was an important fortress of the Roman legions and also had a civilian area. Many of its ruins are preserved in good condition, and the remnants of an important 3rd-century crossing point of the Danube river can be seen next to the Erzsébet bridge in Pest. The three towns, Óbuda and Buda on the hilly western side of the Danube river and Pest on the flat eastern side, were united to form Budapest in 1872.3 There also were other important Roman towns in Pannonia such as Sopianae (Pécs), Scarbantia (Sopron), Savaria (Szombathely), and Gorsium (Tác). After the collapse of the Roman Empire in 433 AD, Attila the Hun ruled in the Carpathian basin. The Avars and Slavic tribes arrived there about 568 AD and the Francs in 803 AD.4 Francis S. Wagner comments further: In the time of the Magyar [Hungarian] Conquest Slavs, Germans and some other peoples already lived there. The Magyars, characteristically, did not enslave them as did earlier the Huns and the Avars to native populations. The economy of the Magyars was built on the contemporary feudal system and not on the barbarian exploitation of subjugated peoples. And, furthermore, while the Huns and the Avars occupied primarily the Great Hungarian Plains, the central base of the Magyar Conquest lay in Dunántúl (Transdanubia): that is, in the very neighborhood of [the] Western cultural sphere. These circumstances, as well as the specific concept of the nomadic nation as practiced by the Magyars, helped develop the fate of this area for centuries to come. In the formative period the old, nomadic nation concept of the Magyars embraced all separate racial (nationality) groups who lived on the territories under Magyar military and political supremacy. This fairly elastic concept of nation saved the Magyars in their long and tragic struggles against the Tatars, Turks and others as well as helping to absorb their invader’s strengths and rejuvenate the whole nation.5

PREFACE: Nanosafe2010: International Conference on Safe Production and Use of Nanomaterials

NASA Astrophysics Data System (ADS)

Sentein, Carole; Schuster, Frédéric; Tardif, François

2011-07-01

Conference logo The second edition of the international conference on the "Safe production and use of nanomaterials" - NanoSafe2010 - was held between 16-18 November at the Maison Minatec congress center located in Grenoble, France. As is recognised, the rapidly developing field of nanotechnologies presents many opportunities and benefits for new materials with significantly improved properties as well as revolutionary applications in the fields of energy, environment, medicine, etc. However, the potential impact of these new materials on human health and the environment is viewed with apprehension. All the security aspects have to be solved in order to reach an acceptable level of risk. The new nano industry can only develop dynamically if these legitimate concerns are satisfactory allayed. Initiated within the framework of the Integrated European project NanoSafe2 and funded by the European Commission under FP6 programs, this biennial event was organized by the French Commissariat à l'Energie Atomique (CEA). NanoSafe2010 had broad international participation from 30 countries representing 4 continents, with registered delegates numbering over 300. The scientific program involved the presentation and discussion of 175 papers, classified as 13 plenary lectures, 117 oral presentations and 45 posters. The conference attracted many of the best known leading scientists and specialists from almost all of the different fields of expertise covering nanosafety issues: Exposure, Characterisation, Detection, Monitoring, Life cycle, Toxicology, Environmental impact, Personal protection, Secure industrial production, Safety parameter evaluation, Standardization, Regulation, and Education. An exhibition took place in parallel with the conference where 16 exhibitors presented the commercial equipment available today in relation to safety during the production or the use of nanomaterials. We believe that this conference, with the above topics, has provided a forum where the many matters of interest to the NanoSafety community have been debated. The success of the conference confirms the need of such a global meeting with the aim of bridging the gap between the best scientists, engineers, exhibitors and participants from countries concerned with safe and responsible nanomaterial activities. Therefore, the third edition of the International NanoSafe Conference "NanoSafe2012" will be held in Grenoble at Minatec, 13-15 November 2012. The meeting was financially supported by generous contributions from the European Commission, La Région Rhône Alpes, la Ville de Grenoble, la Metro, and partners such as CEA, INERIS, Philips, Cordouan Technologies, Nanosight, TSI, Ecomesure, GRIMM Aerosol Technik, Particle Measuring Systems, Respirex, Lux Research, Dekati, Malvern Instruments, TSE Systems, INTERTEK ICS, NANO magazine and IOP Publishing. We would like to express our thanks to all the authors for their time and genuine efforts and to the reviewers for their fruitful comments during the preparation of this volume. The Conference OrganizersCarole SenteinFrédéric SchusterFrançois Tardif Conference photographs Local Organising CommitteeCarole SENTEIN (CEA)Dominique BAGUET (CEA)Didier MOLKO (MINATEC)Audrey SCARINGELLA (MINATEC)Frédéric SCHUSTER (CEA)François TARDIF (CEA) International Advisory CommitteeChair: Frédéric SCHUSTER (CEA, FR), François TARDIF (CEA, FR)Co-chair: Georgios KATALAGARIANAKIS (EC, BE)Paul AMYOTTE (Dalhousie U., CA)Mélanie AUFFAN (CEREGE, FR)Daniel BERNARD (ARKEMA, FR)Jorge BOCZKOWSKI (INSERM, FR)Jean-Yves BOTTERO (CEREGE, FR)Jacques BOUILLARD (INERIS, FR)Jean-Philippe BOURGOIN (CEA, FR)Marie CARRIERE (CEA, FR)Krunal CHOPRA (LSFI, IN)Rolf ECKHOFF (U. Bergen, NO)Michael ELLENBECKER (U. Massachusetts, USA)Claude EMOND (U. Montréal, CA)François GENDARMES (IRSN, FR)Peter HATTO (ISO, UK)Peter HOET (KUL, BE)Jean-Pierre KAISER (Empa, CH)Olivier LE BIHAN (INERIS, FR)Tinh NGUYEN (NIST, USA)Bernd NOWACK (Empa, CH)Günter OBERDÖRSTER (U. Rochester, USA)David PUI (U. Minnesota, USA)Eric QUEMENEUR (CEA, FR)Robert SCHALLER (EPFL, CH)Carole SENTEIN (CEA, FR)Ken TAKEDA (U. Tokyo, JP)Louis TREPIED (MINEFE, FR)Jacques VENDEL (IRSN, FR)Olivier WITSCHGER (INRS, FR) List of Participants AGUY SCordouan, FR ALLEMAN LEcole des Mines de Douai, FR ALPER MUniv. California Berkeley, US ALVES O LUNICAMP, BR AMDAOUD MUniv. Joseph Fourier, FR AMODEO TINERIS, FR AMYOTTE PDalhousie Univ., CA ARAKELIAN M CFundacion Argentina de Nanotecnologia, AR ARZAMASTSEVA ETomsk Polytechnic Univ., RU ASCHBERGER KEuropean Commission-JRC, IT ASHTON AJPCS, GB ASIMAKOPOULOU ACERTH/CPER, GR AUBLANT J-MLNE, FR AUDE-GARCIA CCEA, FR AUFFAN MCEREGE, FR AUGER ACEA, FR BAEK MSeoul Woman's Univ., KR BAEZA AUniv. Paris 7 Diderot, FR BAGUET DCEA, FR BARONE FIstituto Superiore di Sanità, IT BAU SINRS, FR BELLEVILLE PCEA, FR BENAZET SSNPE-Matériaux Energétiques, FR BERGER L-MFraunhofer Institute, DE BERGES MDGUV-IFA, DE BERNARD CNIST, US BERNARD DARKEMA, FR BERNE PCEA, FR BERRET J-FUniv. Paris 7 Diderot, FR BIGORGNE ECNRS, FR BILLAT BPMS, FR BLOCH DCEA, FR BOGDANOVIC-GUILLON AFreelance journalist, FR BOIVIN DRESPIREX France, FR BOLAND SUniv. Paris 7 Diderot, FR BOMBARDIER PFAURE QEI, FR BORASCHI DInstitute of Biomedical Technologies, IT BOTTERO J-YCEREGE, FR BRADLEY JLux Research, US BREGOLI LVeneto Nanotech, IT BRIGNON J-MINERIS, FR BROCHOT CIRSN, FR BROUWER DTNO Quality of Life, NL BUDIMAN TTSE-Systems, DE CABOCHE JEcole des Mines de Douai, FR CALLET GCEA, FR CALOGINE DINERIS, FR CAPONIGRO ALoreal, FR CARRIERE MCEA, FR CASSETTE SThales Research & Technology, FR CHARPENTIER DINERIS, FR CHEN C-CTaiwan Univ., TW CHEN LHealth Canada, CA CHEVALLET MCEA, FR CHOI S-JSeoul Woman's Univ., KR CHOU C-CChung Cheng University, TW CHUNG H-ESeoul Woman's Univ., KR CIMPAN MUniv. Bergen, NO CIOBANU NTU Munich, DE CLARK KInstitute for Work and Health, CH CONJEAUD HUniv. Paris 7 Diderot, FR COSTA PEREIRA CNational Health Institute, PT CROOKS MTSI, GB CUPERTINO DC-Tech Innovation Ltd, GB DASKALOS MCERTH/CPERI, GR DE BERARDIS BIstituto Superiore di Sanità, IT DE MIGUEL YTECNALIA, ES DELAHAYE AAd Air Solutions, FR DEMIDOVA TSevertsov Inst. of Ecology and Evolution, RU DENOO KSolae, GR DERROUGH SCEA, FR DOBRZYNSKA E BCentral Institute for Labour Protection, PL DOLEZ PÉcole de technologie supérieure, CA DOUKI TCEA, FR DRAIS EINRS, FR DUFOUR J-PCILAS, FR DURAN NUNICAMP, BR DURAND CCEA, FR DUTOUQUET CINERIS, FR DUVAL-ARNOULD GSaint-Gobain, FR ECKHOFF R KUniv. Bergen, NO ELLENBECKER M JUniv. Massachusetts Lowell, US EMOND CUniv. Montreal, CA ENGEL SBASF, DE ESTRELA-LOPIS ILeipzig Univ., DE FABBRI MJRC, IT FACCINI MLeitat technological center, ES FESSARD VAnses, FR FILIMUNDI ETSI, DE FIRSTOVA VSRCAMB, RU FLEURY DINERIS, FR FRABOULET DCEA, FR FRESNAY CThales Research & Technology, FR GABORIEAU ACEA, FR GAFFET ENanoMaterials Research Group, FR GALLET SCefic, BE GEIGER DBASF, DE GENSDARMES FIRSN, FR GERRITSEN-EBBEN RTNO Quality of Life, NL GKANIS VDemokritos, GR GLUSHKOVA ARIHOPHE, RU GONZALEZ-FERNANDEZ AUniv. Vigo, ES GOOSSENS HPhilips Research Aerasense, NL GRAHNSTEDT SOslo Univ., NO GREENHILL-HOOPER MRio Tinto Minerals, FR GROSSEAU PEcole des Mines de Saint Etienne, FR GUADAGNINI RUniv. Paris 7 Diderot, FR GUIOT ACEA, FR GUIZARD BCEA, FR HAASE AFederal Institute for Risk Assessment, DE HANINI AUniv. Paris 7 Diderot, FR HAYNES LUniv. de los Andes, VE HEJAZI MUniv. Tehran, IR HENRY FINERIS, FR HERRERA HInstitute for Work and Health, CH HOET PKU Leuven, BE HOLE PNanosight, GB HULME JUniv. Cambridge, GB JI XINERIS, FR JOUHANNAUD JCEA, FR JOUZEL J-NCenter for the Sociology of Organizations, FR JURKSCHAT KOxford Univ., GB KAISER J-PEmpa, CH KANAYA FNat. Center for Global Health and Medicine, JP KATALAGARIANAKIS GEuropean Commission, BE KECK LGrimm Aerosol Technik, DE KELLER MFraunhofer Institute, DE KHLEBNIKOVA NRIHOPHE, RU KHODABANDEH MUniv. Tehran, IR KHOLODENKO VSRCAMB, RU KOBAYASHI NAIST, JP KOPONEN INRCWE, DK KOWAL SINERIS, FR KRYSANOV ESevertsov Inst. of Ecology and Evolution, RU KÜCK AUniv. Bremen, DE KUO Y-MChung Hwa University, TW KVITEK LPalacky Univ., CZ LABILLE JCEREGE, FR LAMMINEN EDekati, FI LARUE CCEA, FR LE BIHAN OINERIS, FR LE DUR DEcomesure, FR LECERF PCILAS, FR LEGRAND MCordouan, FR LELONG CUJF CEA, FR LIMOUSIN SINERIS, FR LINDELOEV JGEA Process Engineering, DK LIU P PChina Jiliang University, CN LIU WCEREGE, FR MACHEREY A-CCNRS, FR MAGGA YCEA, FR MAHLENDORF FUniversity Duisburg-Essen, DE MANIER NINERIS, FR MANZO LUniv. Pavia, IT MARCHETTO ACEA, FR MARCONE GUNICAMP, BR MARI DEPFL, CH MARIE-DESVERGNE CCEA, FR MARIE-LOUISE APSA Peugeot-Citroen, FR MARMUSE LNano-H S.A.S., FR MARRA JPhilips Research Aerasense, NL MASION ACEREGE, FR MATEI EPolitehnica University Bucharest, RO MATSUI YKyoto Univ., JP MATZKE MUniv. Gothenburg, SE MAYNE-L'HERMITE MCEA, FR MELINTE G ABabes-Bolyai University, RO MERINO CGrupo Antolin Ingenieria, ES MICHAUD-SORET ICEA, FR MICHELETTI CJRC, IT MONTIGEL EBasler Versicherungen, CH MONTOYA ERAMEM, ES MOSSUZ VCEA, FR MOTELLIER SCEA, FR MOTZKUS CLNE, FR MUIR BNaneum, GB NAKAMURA KJAPAN NUS CO., JP NEUBAUER NKarlsruhe Institute of Technologie, DE NEUMEISTER LBG ETEM, DE NGUYEN TNIST, US NIORT NINTERTEK, FR NOIRTIN AINTERTEK, FR NOWACK BEmpa, CH NYEMBE DUniv. Johannesburg, ZA Ó CLAONADH NDublin Institute of Technology, IE OBERDÖRSTER GUniv. Rochester, US OGURA IAIST, JP OSTIGUY CIRSST, CA OTSUKA KJFE Techno-Research Corp., JP OUF F-XIRSN, FR OUSACI SALMA, FR PAGET VCEA, FR PAILLEUX MEcole des Mines de Saint Etienne, FR PANDARD PINERIS, FR PANZER OEuropean Research Services, DE PARISELLI FCNRS, FR PERLET JNANO Magazine, GB PETERS RRIKILT, NL PETIT A-NCEA, FR PETKOVIC JNational Institute of Biology, SI PIMENOFF JBeneq, FI PINAULT MCEA, FR PIRET J-PUniv. Namur, BE PONTONE RTekna Plasma Systems, FR POURCHEZ JEcole des Mines de Saint Etienne, FR PRAETORIUS AETH Zurich, CH PRAT OCEA, FR PREVENSLIK TQED Radiations, CN PREVOST CIRSN, FR PROY HUART DFrance Nature Environnement, FR PUI D Y HUniv. Minnesota, US QUARTARARO JPSA Peugeot-Citroen, FR RAULT SUniv. Caen, FR RAVANEL XCEA, FR RAVINDRAN GIRIJA AToyo Univ., JP REBIB FPôle Technologique d'Auvergne, FR RECHATIN J-LIRELEC, FR REYNIER MINRS, FR RICAUD MINRS, FR RIEDIKER MInstitut de Santé au Travail, CH RMILI BINERIS, FR ROGERIEUX FINERIS, FR ROLANDO CUniv. Lille 1, FR ROMERO AFreelance journalist, DE ROUCHER BCILAS, FR SAEZ J-PNanosight, GB SAFI MUniv. Paris 7 Diderot, FR SAKAI NKyoto Univ., JP SALVI OINERIS, FR SANFINS EUniv. Paris 7 Diderot, FR SAVOLAINEN KFIOH, FI SCHALLER REPFL, CH SCHMID KInstitute for Work and Health, CH SCHUBERT CCEA, FR SCHUSTER FCEA, FR SCHWEINBERGER FTU Munich, DE SCIFO LTECNALIA, ES SEABRA AUNICAMP, BR SEBASTIEN PSaint-Gobain, FR SENE CSTEPAN, FR SENTEIN CCEA, FR SHEN JStockholm Univ., SE SHINKAI YTokyo Univ., JP SICARD YUJF CEA, FR SIKHWIVHILU LNat. Centre for Nanostructured Materials, ZA SILLANPÄÄ MFinnish Environment Institute, FI SIMON JCEA, FR SINESI SCRP, IT SIRVEN J-BCEA, FR SIRVIÖ SFIOH, FI SOERENSEN SSolae, DK SON S WKorea Univ., KR SUBLEMONTIER OCEA, FR SYMON ARUSNANO Metrology Center, RU SYMONDS JCAMBUSTION, GB TARANTINI AAnses, FR TARDIF FCEA, FR TAKEDA KTokyo Univ., JP TERRAY MMalvern Instruments, FR THABUIS CBureau Veritas, FR THIERIET NAnses, FR TIKKANEN JTHL, FI TROUILLER BINERIS, FR UKKONEN ADekati, FI UMEMURA KTokyo University, JP USTACHE AINERIS, FR VÄISÄNEN PRautaruukki Oyj, FI VAN DEN BRINK WPhilips Research Aerasense, NL VAN TONGEREN MInstitute of Occupational Medicine, GB VANDELAC LUniv. Québec, CA VAQUERO CTECNALIA, ES VEERANARAYANAN SToyo Univ., JP VENDEL JIRSN, FR VERBIST KArboUnie, NL VIANA MIDAEA-CSIC, ES VIDAUD CCEA, FR VIGNES AINERIS, FR VOETZ MBayer Technology Services, DE WAHLBERG MGEA Process Engineering, DK WALSER T DETH Zurich, CH WARTENBERG NCEA, FR WEIGEL SRIKILT, NL WENZLER ETSE-Systems, DE WHITELEY CLancaster Univ., GB WIJMA ERIKILT, NL WILDE CAvantiCell Science Ltd, GB WILLIAMS DManufacture Michelin, FR WITSCHGER OINRS, FR WOHLLEBEN WBASF, DE WU QDet Norske Veritas, NO YAGISHITA TJFE Techno-Research Corporation, JP YU JSeoul Woman's Univ., KR ZAPÓR LCIOP-PIB, PL ZIMMERMANN ECEA, FR

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48 CFR 9.104-1 - General standards.

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40 CFR 141.51 - Maximum contaminant level goals for inorganic contaminants.

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TG/DTG/DTA evaluation of flame retarded cotton fabrics and comparison to cone calorimeter data.

PubMed

Šimkovic, Ivan

2012-10-01

Unbleached cotton fabrics (UCF) with 12.5% polypropylene scrim treated with two phosphate-urea based fire-retardant (FR) formulations were evaluated for FR properties using thermogravimetry/differential thermogravimetry/differential thermal analysis (TG/DTG/DTA) method. In addition to testing the two FR-treated unbleached cotton fabrics (CF-FR1 and CF-FR2), bleached cotton fabric (BCF) treated with the two FR formulations (BCF-FR1 and BCF-FR2) was evaluated. Both formulations were washable with add-on of FR chemicals at 18.7% (FR1) or 17.4% (FR2) for UCF and 22.5% (FR1) or 24.9% (FR2) for BCF. The decreasing order of sums at maximal rates of samples degradation in air environment according to DTG method was: BCF (21.40%/min)>UCF (12.91%/min)>BCF-FR2 (12.83%/min)>BCF-FR1 (11.68%/min)>CF-FR2 (10.20%/min)>CF-FR1 (9.73%/min). It indicates that both formulations cause the decrease of thermooxidation of the products at slower rates than the starting material. Several endo- and exothermic peaks observed by DTA in inert and oxidative environment gives additional information about the degradation process. The order of decreasing thermal responses of the studied samples based on sums of DTA peak values of endothermic and exothermic peaks in air environment is: UCF (0.597 °C/mg)>BCF (0.120 °C/mg)>CF-FR1 (0.089 °C/mg)>BCF-FR1 (0.077 °C/mg)>CF-FR2 (0.062 °C/mg)>BCF-FR2 (0.053 °C/mg). This is in agreement with the cone calorimeter results according to which the flammability properties are improving with the decreasing heat release rates or ignition time prolongation in order: UCF>CF-FR1>CF-FR2. The advantage of TG/DTG/DTA method is slower linear heating rate, which allows the more detailed evaluation of the light and flammable cotton fabric. Copyright © 2012 Elsevier Ltd. All rights reserved.

76 FR 7101 - Airworthiness Directives; Hamilton Sundstrand Propellers Model 247F Propellers

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-09

..., except Federal holidays. The AD docket contains this AD, the regulatory evaluation, any comments received... blades part number (P/N) 817370-1, S/Ns FR2449 to FR2958 inclusive, FR20010710 to FR20010722 inclusive, and FR20010723RT to FR20020127RT inclusive, before December 31, 2010. We determined that those S/N...

75 FR 62333 - Airworthiness Directives; Hamilton Sundstrand Propellers Model 247F Propellers

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-08

...., Monday through Friday, except Federal holidays. The AD docket contains this proposed AD, the regulatory... that the 247F propeller blades, P/N 817370-1, S/Ns FR2449 to FR2958 inclusive, FR20010710 to FR20010722 inclusive, and FR20010723RT to FR20020127RT inclusive, manufactured since January 1999, might also have...

78 FR 24745 - Agency Information Collection Activities: Announcement of Board Approval Under Delegated...

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2013-04-26

... Securities Dealer. Agency form number: FR MSD-4; FR MSD-5. OMB control number: 7100-0100; 7100-0101... are municipal securities dealers. Estimated annual reporting hours: FR MSD-4, 20 hours; FR MSD-5, 13 hours. Estimated average hours per response: FR MSD-4, 1 hour; FR MSD-5, 0.25 hours. Number of...

48 CFR 236.273 - Construction in foreign countries.

Code of Federal Regulations, 2010 CFR

2010-10-01

... foreign governments. [56 FR 36421, July 31, 1991, as amended at 62 FR 2856, Jan. 17, 1997; 62 FR 34127, June 24, 1997; 63 FR 11538, Mar. 9, 1998; 66 FR 49861, Oct. 1, 2001; 70 FR 35545, June 21, 2005...

48 CFR 236.273 - Construction in foreign countries.

Code of Federal Regulations, 2011 CFR

2011-10-01

... foreign governments. [56 FR 36421, July 31, 1991, as amended at 62 FR 2856, Jan. 17, 1997; 62 FR 34127, June 24, 1997; 63 FR 11538, Mar. 9, 1998; 66 FR 49861, Oct. 1, 2001; 70 FR 35545, June 21, 2005...

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12 CFR 620.4 - Preparing and providing the annual report.

Code of Federal Regulations, 2011 CFR

2011-01-01

... misleading. [51 FR 8656, Mar. 13, 1986. Redesignated and amended at 56 FR 29421, 29422, June 27, 1991; 62 FR 15093, Mar. 31, 1997; 66 FR 14301, Mar. 12, 2001; 67 FR 16633, Apr. 8, 2002; 71 FR 76119, Dec. 20, 2006...

77 FR 50163 - Affirmative Decisions on Petitions for Modification Granted in Whole or in Part

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...: Docket Number: M-2009-050-C. FR Notice: 75 FR 3256 (1/20/2010). Petitioner: Wolf Run Mining Company, 300... Number: M-2011-010-C. FR Notice: 76 FR 22150 (4/20/2011). Petitioner: Brooks Run Mining Company, LLC, 208... systems). Docket Number: M-2011-012-C. FR Notice: 76 FR 37838 (6/28/2011). Petitioner: Patton Mining, LLC...

76 FR 58300 - Affirmative Decisions on Petitions for Modification Granted in Whole or in Part

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... Affected: 30 CFR 75.1700 (Oil and gas wells). Docket Number: M-2009-005-C. FR Notice: 74 FR 23747 (May 20... CFR 75.1700 (Oil and gas wells). Docket Number: M-2009-006-C. FR Notice: 74 FR 23748 (May 20, 2009.... Regulation Affected: 30 CFR 75.1700 (Oil and gas wells). Docket Number: M-2009-039-C. FR Notice: 74 FR 63414...

Histological distribution of FR-1, a cyclic RGDS-peptide, binding sites during early embryogenesis, and isolation and initial characterization of FR-1 receptor in the sand dollar embryo.

PubMed

Katow, H; Yamamoto, Y; Sofuku, S

1997-04-01

A fibronectin-related synthetic cyclic H-Cys-Arg-Gly-Asp-Ser-Pro-Ala-Ser-Ser-Cys-OH (RGDSPASS) peptide (FR-1) binding site in the embryo of the sand dollar Clypeaster japonicus was specified using dansyl-labeled FR-1 (Dns-FR-1) and horseradish peroxidase-labeled FR-1, and an FR-1 receptor was isolated using FR-1-affinity column chromatography. The FR-1 introduced to the blastocoel of blastulae inhibited primary mesenchyme cell (PMC) migration in mesenchyme blastulae, and complete gastrulation and spicule differentiation in gastrulae. The Dns-FR-1 bound to the entire basal side of the ectoderm in mesenchyme blastulae, and then restricted to the basal side of the ectoderm at the apical tuft region and the vegetal hemisphere in early gastrulae. The cytoplasm of the archenteron also bound to Dns-FR-1. In PMC, Dns-FR-1 bound to the nucleus and cytoplasmic reticular features. In unfertilized eggs, Dns-FR-1 bound to the entire cytoplasm, particularly to the oval-shaped granules and the nuclear envelope, but only to the cytoplasm after fertilization. Relative molecular mass (Mr) of the FR-1-binding protein was 240 kDa under non-reducing conditions and 57 kDa under reducing conditions. The FR-1 receptor protein bound anti-sea urchin integrin (Spl) betaL subunit antibodies raised against the embryos of Strongylocentrotus purpuratus. Immunohistochemistry showed that the antibody binding site was similar to the histochemical distribution of Dns-FR-1. However, Mr of the FR-1 receptor is distinctively larger than that of the Spl betaL subunit.

75 FR 12564 - Issuance of Permits

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2010-03-16

... Worth Zoo 74 FR 55062; October February 19, 2010 26, 2009. 223400 Earth Promise, doing 74 FR 46222... San 75 FR 427; January 5. February 26, 2010 Diego. 2010. 230742 The Phoenix Zoo 74 FR 66675; December February 2, 2010 16, 2009. 231594 Seneca Park Zoo 74 FR 58977; November February 2, 2010 16, 2009. 232558...

76 FR 46807 - Agency Information Collection Activities: Announcement of Board Approval Under Delegated...

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2011-08-03

... collections are mandatory. FR 2030 and FR 2030a: (12 U.S.C. 222, 282, 248(a) and 321). FR 2056: (12 U.S.C. 287, 248(a) and (i)). FR 2086: (12 U.S.C. 287, 248(a) and (i)). FR 2086a: (12 U.S.C. 321, 287, 248(a)). FR... to obtain a benefit (12 U.S.C. 338a, and 12 CFR 208.22). Individual respondent data generally are not...

76 FR 49769 - Proposed Agency Information Collection Activities; Comment Request

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2011-08-11

... partner or limited partner, (4) adding event types to the 4(k) schedule, (5) requiring the reporting of...: FR Y-10, FR Y-6, and FR Y-7. OMB control number: 7100-0297. Frequency: FR Y-10: Event-generated; FR Y... an event generated information collection submitted by FBOs; top-tier BHCs; state member banks...

Toward Understanding the Fanaroff-Riley Dichotomy in Radio Source Morphology and Power

NASA Astrophysics Data System (ADS)

Baum, Stefi A.; Zirbel, Esther L.; O'Dea, Christopher P.

1995-09-01

In Paper I we presented the results of a study of the interrelationships between host galaxy magnitude, optical line luminosity, and radio luminosity in a large sample of Fanaroff-Riley classes 1 and 2 (FR 1 and FR 2) radio galaxies. We report several important differences between the FR 1 and FR 2 radio galaxies. At the same host galaxy magnitude or radio luminosity, the FR 2's produce substantially more optical line emission (by roughly an order of magnitude or more) than do FR 1's. Similarly, FR 2 sources produce orders of magnitude more line luminosity than do radio-quiet galaxies of the same optical magnitude, while FR 1 sources and radio-quiet galaxies of the same optical magnitude produce similar line luminosities. Combining these results with previous results from the literature, we conclude that while the emission-line gas in the FR 2's is indeed photoionized by a nuclear UV continuum source from the AGN, the emission-line gas in the FR 1's may be energized predominantly by processes associated with the host galaxy itself. The apparent lack of a strong UV continuum source from the central engine in FR 1 sources can be understood in two different ways. In the first scenario, FR l's are much more efficient at covering jet bulk kinetic energy into radio luminosity than FR 2's, such that an FR 1 has a much lower bolometric AGN luminosity (hence nuclear UV continuum source) than does an FR 2 of the same radio luminosity. We discuss the pros and cons of this model and conclude that the efficiency differences needed between FR 2 and FR 1 radio galaxies are quite large and may lead to difficulties with the interpretation since it would suggest that FR 2 radio source deposit very large amounts of kinetic energy into the ISM Intracluster Medium. However, this interpretation remains viable. Alternatively, it may be that the AGNs in FR 1 sources simply produce far less radiant UV energy than do those in FR 2 sources. That is, FR 1 sources may funnel a higher fraction of the total energy output from the AGNs into jet kinetic energy versus radiant energy than do FR 2 sources. If this interpretation is correct, then this suggests that there is a fundamental difference in the central engine and/or in the immediate "accretion region" around the engine in FR 1 and FR 2 radio galaxies. We note also the absence of FR 1 sources with nuclear broad line regions and suggest that the absence of the BLR is tied to the absence of the "isotropic" nuclear UV continuum source in FR 1 sources. We put forth the possibility that the FR 1/FR 2 dichotomy (i.e., the observed differences in the properties of low- and high-power radio sources) is due to qualitative differences in the structural properties of the central engines in these two types of sources. Following early work by Rees et al. (1982), we suggest the possibility that FR 1 sources are produced when the central engine is fed at a lower accretion rate, leading to the creation of a source in which the ratio of radiant to jet bulk kinetic energy is low, while FR 2 sources are produced when the central engine is fed at a higher accretion rate, causing the central engine to deposit a higher fraction of its energy in radiant energy. We further suggest the possibility that associated differences in the spin properties of the central black hole between FR 1 (lower spin) and FR 2 (higher spin) sources may be responsible for the different collimation properties and Mach numbers of the jets produced by these two types of radio-loud galaxies. This scenario, although currently clearly speculative, is nicely consistent with our current picture of the triggering, feeding, environments, and evolution of powerful radio galaxies. This model allows for evolution of these properties with time for example, the mass accretion rate and BH spin may decline with time causing an FR 2 radio source or quasar to evolve into a FR 1 radio source.

78 FR 35766 - North Carolina: Final Authorization of State Hazardous Waste Management Program Revisions

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-14

..., effective March 19, 1991 (56 FR 1929); April 10, 1991, effective June 9, 1991 (56 FR 14474); July 19, 1991, effective September 17, 1991 (56 FR 33206); April 27, 1992, effective June 26, 1992 (57 FR 15254); December... Significantly Affect Energy Supply, Distribution, or Use'' (66 FR 28355, May 22, 2001) because it is not a...

75 FR 55580 - Agency Information Collection Activities: Announcement of Board Approval Under Delegated...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-13

... authority of the extension for three years, without revision, of the following reports: 1. Report title...: FR 1373a survey, one or two times per year; FR 1373a discussion groups, two times a year. FR 1373b small-panel survey, two times a year; FR 1373b large-panel survey, one time per year. Reporters: FR...

38 CFR 3.54 - Marriage dates.

Code of Federal Regulations, 2010 CFR

2010-07-01

...) Indian wars—March 4, 1917. (iii) Spanish-American War—January 1, 1938. (iv) Mexican border period and... marriage has been met. (Authority: 38 U.S.C. 103(b)) [26 FR 1567, Feb. 24, 1961, as amended at 27 FR 6498... FR 18300, May 3, 1976; 44 FR 22718, Apr. 17, 1979; 54 FR 31829, Aug. 2, 1989; 56 FR 5756, Feb. 13...

Critical Habitat :: NOAA Fisheries

Science.gov Websites

82 FR 51186 (comments close 1/02/18) Beluga Whale Cook Inlet 2011 76 FR 20180 Go to Data Hawaiian Monk Seal 1988, 1986, 2015 53 FR 18988, 51 FR 16047, 80 FR 50925 Go to Data [zip] (excluded areas Revise (Feb 2015) 2006 71 FR 69054 Go To Data [zip] North Atlantic Right Whale Northeast Southeast 1994

Calculation of former ELA depressions in the Himalaya - a comparative analysis

NASA Astrophysics Data System (ADS)

Wagner, M.

2009-04-01

For the reconstruction of former Equilibrium Line Altitudes (ELA) and ELA depressions in the Himalaya, the group of the Toe-to-Summit-Altitude-Methods (TSAM) is most suited. In this investigation the Kuhle (1986) method that is particularly tailored to the extreme high mountain relief, as well as the widely used Höfer (1879) method and Louis (1954/55) method, have been applied. Applying the relief specific correction factor FSD (Factor for snowline deviation) in the Kuhle method, it is thereby possible to simulate the shifting position of the ELA within the vertical extension of the glacier in dependence on the relief characteristics and glacial type. The results of this work, carried out along the Kali Gandaki in central Nepal, illustrate that as a rule, the Louis method results in the highest ELAs and the lowest ELA depressions, while the Höfer method yields the lowest ELAs and the highest ELA depressions. In affirmation of the literature, the Louis method tends to overestimate the ELA, since using the maximum peak height, especially for large glaciers in mountain ranges with high relief energy, leads to an overly high position of the glacier upper limit. With respect to the Höfer method, the suspicion already voiced by Höfer (1879) himself, that with the use of his method, the for the Himalaya typically high elevated, and with marginal gradient toward the valley moving ridge progressions, would lead to a too low ELA, can be affirmed. Clearly to be disputed, however, is the statement of Gross et al. (1976) that the Höfer method leads to an overestimation of the ELA. The reason for this can be found in a wrong computation of the mean ridge height above the ELA and consequently of the ELA itself within the Höfer method, based on the erroneous assumption that otherwise the ELA could not be calculated due to a circular conclusion (Gross et al. 1976). As is evidenced by this study, the Kuhle method mediates between the empiric overly high values of the Louis method and the overly low values of the Höfer method, because of a mediating definition of the accumulation zone upper limit. Additionally, over the FSD, Kuhle allows for a high degree of adaptation to the extreme Himalaya relief, and within limitations from the change of the relief constellation, which stems from transverse valley's characteristics of the Kali Gandaki. Therefore, the results of the Kuhle method must be affirmed as reflecting the greatest conformity with the actual values of the ELA and the ELA depression. References: Gross, G., H. Kerschner, G. Patzelt (1976): Methodische Untersuchungen über die Schneegrenze in alpinen Gletschergebieten. Zeitschrift für Gletscherkunde und Glazialgeologie 12 (2): 223-251. Höfer von Heimhalt, H. (1879): Gletscher- und Eiszeitstudien. Sitzungsberichte der Akademie der Wissenschaften in Wien, Mathematisch-Naturwissenschaftliche Klasse, Abteilung I, Biologie, Mineralogie, Erdkunde 79: 331-367. Kuhle, M. (1986): Schneegrenzberechnung und typologische Klassifikation von Gletschern anhand spezifischer Reliefparameter. Petermanns Geographische Mitteilungen 130: 41-51. Louis, H. (1954/55): Schneegrenze und Schneegrenzbestimmung. Geographisches Taschenbuch 1954/55: 414-418.

The Pedotopia Project: A Transdisciplinary Experiment in Soil Education

NASA Astrophysics Data System (ADS)

Toland, A.; Wessolek, G.

2012-04-01

In the absence of every-day interactions with the land, a hands-on, comprehensive soil education across disciplines and ages is necessary. Soil education is usually integrated into earth science and geography curricula and only rarely into social science, arts and humanities programs. Furthermore, an emphasis on measurement and modeling in conventional classroom science often neglects aesthetic, moral and other non-quantifiable values, precluding a broader cultural context in which soil education could take place. The arts play a vital role in communicating environmental issues to the greater public and represent a dynamic approach to help students discover soil complexity in new and unexpected ways. Artistic methods have recently been introduced as pedagogical tools in soil awareness-raising programs for children and youth. Painting with soil has become an interesting new approach to soil education from Kindergarten to University levels (SZLEZAK 2008). And a growing amount of literature describes artists who have undertaken different soil issues, suggesting that such artistic focus may improve wider understanding and appreciation of soil conservation issues (FELLER et al 2010, TOLAND & WESSOLEK 2010, WAGNER 2002). How can art contribute to soil science, policy and education - both with the aim of generating greater public understanding, but also by honing creative methods to confront problems such as contamination, erosion, and urban sprawl? What artistic approaches exist to protect and restore soils as well as our relationship to the land? And how can these approaches support current soil education goals? These questions were addressed in the transdisciplinary soil seminar, "Pedotopia - Re-sourcing Urban Soils" from September 2010 to September 2011 in Berlin. A cooperation between the Technical University of Berlin's Department of Soil Protection and the Berlin University of Arts' Institute for Art in Context, the project served as a teaching experiment as well as a platform for the production of new soil-oriented artworks. An exhibition of the resulting works as well as a symposium on the cultural values of soil conservation was held at the annual meeting of the German Soil Science Society (DBG) in 2011 in Berlin. In the following paper we will present the Pedotopia project as a case study in transdisciplinary soil education. We will highlight main points of the curriculum, present the results of the project and address challenges and future considerations of transdisciplinary soil education. SOURCES FELLER, LARDY and UGOLINI (2010): The Representation of Soil in the Western Art: From Genesis to Pedogenesis. In: Feller and Landa (Hrsg.) Soil and Culture. Dordrecht, Heidelberg, London and New York: Springer Science + Business Media B.V.: 3-21 SZLEZAK, E. (2009) "Soilart with the Colours of the Earth". In: Amt der NÖ LandesregierungAbteilung Landentwicklung. Stand 2009. http://www.soilart.eu/1-0-Home.htm (abgerufen am 20. Dezember 2011) TOLAND, A. & WESSOLEK, G. (2010): Merging Horizons - Soil Science and Soil Art. In: Feller and Landa (Hrsg.) Soil and Culture. Dordrecht, Heidelberg, London and New York: Springer Science + Business Media B.V.: 45-66 WAGNER, M. (2002): Erde als Material künstlerische Gestaltung. In: BUSCH, B. (2002) (Hrsg.): Erde. Schriftenreihe Forum, Bd. 11, Elemente des Naturhaushalts III. Kunst- und Ausstellungshalle der Bundesrepublik Deutschland GmbH, Köln, 246-260

49 CFR 172.502 - Prohibited and permissive placarding.

Code of Federal Regulations, 2011 CFR

2011-10-01

... apply until October 1, 2001 to a safety sign or safety slogan (e.g., “Drive Safely” or “Drive Carefully..., 55 FR 52599, Dec. 21, 1990, as amended at 56 FR 66259, Dec. 20, 1991; Amdt. 172-151, 62 FR 1230, Jan. 8, 1997; 62 FR 39389 and 39407, July 22, 1997; 66 FR 8647, Feb. 1, 2001; 66 FR 33426, June 21, 2001...

76 FR 7091 - Notice of Intent To Require Reporting Forms for Savings and Loan Holding Companies

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-08

... title: Financial Statements for Bank Holding Companies. Agency form number: FR Y-9C, FR Y-9LP, FR Y-9SP... financial statements for the consolidated BHC and the parent holding company only. The FR Y-9 family of... condition to ensure safe and sound operations. The FR Y-9C consists of standardized financial statements...

49 CFR Appendix B to Subchapter B... - Special Agents

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 5 2010-10-01 2010-10-01 false Special Agents B Appendix B to Subchapter B of... and 31503; and 49 CFR 1.73) [35 FR 1016, Jan. 24, 1970 as amended at 36 FR 16067, Aug. 19, 1971; 43 FR 20011, May 10, 1978; 44 FR 46425, July 10, 1980; 49 FR 38290, Sept. 28, 1984; 60 FR 38749, July 28, 1995...

49 CFR Appendix B to Subchapter B... - Special Agents

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 5 2011-10-01 2011-10-01 false Special Agents B Appendix B to Subchapter B of... and 31503; and 49 CFR 1.73) [35 FR 1016, Jan. 24, 1970 as amended at 36 FR 16067, Aug. 19, 1971; 43 FR 20011, May 10, 1978; 44 FR 46425, July 10, 1980; 49 FR 38290, Sept. 28, 1984; 60 FR 38749, July 28, 1995...

76 FR 44613 - Notice of Buy American Waiver Under the American Recovery and Reinvestment Act of 2009

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-26

... the bow thruster [75 FR 9256 (March 1, 2010)], anti-roll tank control system [76 FR 184 (January 3, 2011)], weather fax [76 FR 186 (January 3, 2011)], ultrasonic antifouling system [76 FR 35920 (June 20, 2011)], and HVAC generators [76 FR 35919 (June 20, 2011)]; all of which were in excess of this $10,000...

47 CFR 0.31 - Functions of the Office.

Code of Federal Regulations, 2012 CFR

2012-10-01

... other general inquiries by consumers. (Secs. 2, 3, 4, 5, 301, 303, 307, 308, 309, 315, 317, 48 Stat., as..., 301, 303, 307, 308, 309, 315, 317) [45 FR 28718, Apr. 30, 1980, as amended at 46 FR 45342, Sept. 11..., July 13, 1998; 64 FR 60716, Nov. 8, 1999; 67 FR 13217, Mar. 21, 2002; 68 FR 11747, Mar. 12, 2003; 69 FR...

47 CFR 0.31 - Functions of the Office.

Code of Federal Regulations, 2013 CFR

2013-10-01

... other general inquiries by consumers. (Secs. 2, 3, 4, 5, 301, 303, 307, 308, 309, 315, 317, 48 Stat., as..., 301, 303, 307, 308, 309, 315, 317) [45 FR 28718, Apr. 30, 1980, as amended at 46 FR 45342, Sept. 11..., July 13, 1998; 64 FR 60716, Nov. 8, 1999; 67 FR 13217, Mar. 21, 2002; 68 FR 11747, Mar. 12, 2003; 69 FR...

47 CFR 0.31 - Functions of the Office.

Code of Federal Regulations, 2014 CFR

2014-10-01

... other general inquiries by consumers. (Secs. 2, 3, 4, 5, 301, 303, 307, 308, 309, 315, 317, 48 Stat., as..., 301, 303, 307, 308, 309, 315, 317) [45 FR 28718, Apr. 30, 1980, as amended at 46 FR 45342, Sept. 11..., July 13, 1998; 64 FR 60716, Nov. 8, 1999; 67 FR 13217, Mar. 21, 2002; 68 FR 11747, Mar. 12, 2003; 69 FR...

Food restriction affects Y-maze spatial recognition memory in developing mice.

PubMed

Fu, Yu; Chen, Yanmei; Li, Liane; Wang, Yumei; Kong, Xiangyang; Wang, Jianhong

2017-08-01

The ambiguous effects of food restriction (FR) on cognition in rodents have been mostly explored in the aged brain by a variety of paradigms, in which either rewards or punishments are involved. This study aims to examine the effects of chronic and acute FR with varying intensities on spatial recognition memory in developing mice. We have used a Y-maze task that is based on the innate tendency of rodents to explore novel environments. In chronic FR, mice had 70-30% chow of control for seven weeks. In acute FR, mice were food restricted for 12-48h before the tests. We found that chronic FR had no effect on the preference of mice for novelty in the Y-maze, but severe FR (50-30% of control) caused impairment on spatial recognition memory. The impairment significantly correlated with the slow weight growth induced by FR. Acute FR also did not affect the novelty preference of mice, but either improved or impaired the memory retention. These data suggest chronic FR impairs Y-maze spatial recognition memory in developing mice depending on FR intensity and individual tolerability of the FR. Moreover, acute FR exerts diverse effects on the memory, either positive or negative. Our findings have revealed new insights on the effects of FR on spatial recognition memory in developing animals. Copyright © 2017 ISDN. Published by Elsevier Ltd. All rights reserved.

76 FR 41698 - Approval and Promulgation of Air Quality Implementation Plans; New Mexico; Section 110(a)(2...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-15

.../30/1995 9/26/1997, 62 FR 50514 Part 11 Asphalt Process 11/30/1995 9/26/1997, 62 FR 50514 Equipment..., 62 FR 50514 Equipment-Sulfur Dioxide. Part 32 Coal Burning 11/30/1995 9/26/1997, 62 FR 50514... Sulfuric Acid 11/30/1995 9/26/1997, 62 FR 50514 Production Units- Sulfur Dioxide, Acid Mist and Visible...

7 CFR 29.1044 - Orange Red (FR).

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Orange Red (FR). 29.1044 Section 29.1044 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing... Type 92) § 29.1044 Orange Red (FR). A yellowish red. [42 FR 21092, Apr. 25, 1977. Redesignated at 47 FR...

47 CFR 36.621 - Study area total unseparated loop cost.

Code of Federal Regulations, 2010 CFR

2010-10-01

... support payments beginning July 1, 2001, shall be limited to the lesser of: (i) The actual average monthly..., as amended at 56 FR 27422, June 14, 1991; 62 FR 32948, June 17, 1997; 62 FR 40748, July 30, 1997; 63 FR 2124, Jan. 13, 1998; 66 FR 30086, June 5, 2001] ...

76 FR 18536 - Agency Information Collection Activities Under OMB Review

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2011-04-04

... soliciting comments on this collection of information was published on January 11, 2011. 76 FR 1603. \\2... FR 1603, 1604. \\5\\ See CFTC NPRM: End-User Exception to Mandatory Clearing of Swaps, 75 FR 80747... FR 1603, 1604. The estimated average hourly burden was estimated at .5 hours. Burden Statement: The...

76 FR 13188 - Agency Information Collection Activities: Announcement of Board Approval Under Delegated...

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2011-03-10

...: Cynthia Ayouch, Acting Federal Reserve Board Clearance Officer (202-452-3829), Division of Research and... Systems Surveys: Ad Hoc Payments Systems Survey, Currency Quality Sampling Survey, Currency Quality Survey, and Currency Functionality Survey. Agency form number: FR 3054a, FR 3054b, FR 3054c, and FR 3054d. OMB...

76 FR 14812 - Final Regulation Extending the Reporting Deadline for Year 2010 Data Elements Required Under the...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-18

.... Suppliers of Natural Gas and 221210 Natural gas Natural Gas Liquids. distribution facilities. 211112 Natural gas liquid extraction facilities. Suppliers of Industrial 325120 Industrial gas Greenhouse Gases..., 75 FR Natural Gas Liquids. 66434, 75 FR 79092. Suppliers of Industrial OO 74 FR 56260, 75 FR...

The ratio of red light to far red light alters Arabidopsis axillary bud growth and abscisic acid signalling before stem auxin changes.

PubMed

Holalu, Srinidhi V; Finlayson, Scott A

2017-02-01

Arabidopsis thaliana shoot branching is inhibited by a low red light to far red light ratio (R:FR, an indicator of competition), and by loss of phytochrome B function. Prior studies have shown that phytochrome B deficiency suppresses bud growth by elevating systemic auxin signalling, and that increasing the R:FR promotes the growth of buds suppressed by low R:FR by inhibiting bud abscisic acid (ABA) accumulation and signalling. Here, systemic auxin signalling and bud ABA signalling were examined in the context of rapid bud responses to an increased R:FR. Increasing the R:FR promoted the growth of buds inhibited by a low R:FR within 6 h. Relative to a low R:FR, bud ABA accumulation and signalling in plants given a high R:FR showed a sustained decline within 3 h, prior to increased growth. Main stem auxin levels and signalling showed a weak, transient response. Systemic effects and those localised to the bud were further examined by decapitating plants maintained either under a low R:FR or provided with a high R:FR. Increasing the R:FR promoted bud growth before decapitation, but decapitated plants eventually formed longer branches. The data suggest that rapid responses to an increased R:FR may be mediated by changes in bud ABA physiology, although systemic auxin signalling is necessary for sustained bud repression under a low R:FR. © The Author 2017. Published by Oxford University Press on behalf of the Society for Experimental Biology.

40 CFR 52.2381 - EPA-approved Vermont State regulations.

Code of Federal Regulations, 2012 CFR

2012-07-01

...-fired boilers. 3/24/79 1/30/80 45 FR 6781 (c)(9) Related to PSD. 11/4/79 2/19/80 45 FR 10775 (c)(10) All... FR 6781 (c)(9) For PSD Plan. 3/24/79 2/19/80 45 FR 10775 (c)(10) For NSR Plan. Section 5-406Required air modeling 3/24/79 1/30/80 45 FR 6781 (c)(9) For PSD Plan. 3/24/79 2/19/80 45 FR 10775 (c)(10) For...

40 CFR 52.2381 - EPA-approved Vermont State regulations.

Code of Federal Regulations, 2010 CFR

2010-07-01

...-fired boilers. 3/24/79 1/30/80 45 FR 6781 (c)(9) Related to PSD. 11/4/79 2/19/80 45 FR 10775 (c)(10) All... FR 6781 (c)(9) For PSD Plan. 3/24/79 2/19/80 45 FR 10775 (c)(10) For NSR Plan. Section 5-406Required air modeling 3/24/79 1/30/80 45 FR 6781 (c)(9) For PSD Plan. 3/24/79 2/19/80 45 FR 10775 (c)(10) For...

40 CFR 52.2381 - EPA-approved Vermont State regulations.

Code of Federal Regulations, 2014 CFR

2014-07-01

...-fired boilers. 3/24/79 1/30/80 45 FR 6781 (c)(9) Related to PSD. 11/4/79 2/19/80 45 FR 10775 (c)(10) All... FR 6781 (c)(9) For PSD Plan. 3/24/79 2/19/80 45 FR 10775 (c)(10) For NSR Plan. Section 5-406Required air modeling 3/24/79 1/30/80 45 FR 6781 (c)(9) For PSD Plan. 3/24/79 2/19/80 45 FR 10775 (c)(10) For...

40 CFR 52.2381 - EPA-approved Vermont State regulations.

Code of Federal Regulations, 2013 CFR

2013-07-01

...-fired boilers. 3/24/79 1/30/80 45 FR 6781 (c)(9) Related to PSD. 11/4/79 2/19/80 45 FR 10775 (c)(10) All... FR 6781 (c)(9) For PSD Plan. 3/24/79 2/19/80 45 FR 10775 (c)(10) For NSR Plan. Section 5-406Required air modeling 3/24/79 1/30/80 45 FR 6781 (c)(9) For PSD Plan. 3/24/79 2/19/80 45 FR 10775 (c)(10) For...

40 CFR 52.2381 - EPA-approved Vermont State regulations.

Code of Federal Regulations, 2011 CFR

2011-07-01

...-fired boilers. 3/24/79 1/30/80 45 FR 6781 (c)(9) Related to PSD. 11/4/79 2/19/80 45 FR 10775 (c)(10) All... FR 6781 (c)(9) For PSD Plan. 3/24/79 2/19/80 45 FR 10775 (c)(10) For NSR Plan. Section 5-406Required air modeling 3/24/79 1/30/80 45 FR 6781 (c)(9) For PSD Plan. 3/24/79 2/19/80 45 FR 10775 (c)(10) For...

FR0CAT: a FIRST catalog of FR 0 radio galaxies

NASA Astrophysics Data System (ADS)

Baldi, R. D.; Capetti, A.; Massaro, F.

2018-01-01

With the aim of exploring the properties of the class of FR 0 radio galaxies, we selected a sample of 108 compact radio sources, called FR0CAT, by combining observations from the NVSS, FIRST, and SDSS surveys. We included in the catalog sources with redshift ≤0.05, with a radio size ≲5 kpc, and with an optical spectrum characteristic of low-excitation galaxies. Their radio luminosities at 1.4 GHz are in the range 1038 ≲ νL1.4 ≲ 1040 erg s-1. The FR0CAT hosts are mostly (86%) luminous (-21 ≳ Mr ≳ -23) red early-type galaxies with black hole masses 108 ≲ MBH ≲ 109M⊙. These properties are similar to those seen for the hosts of FR I radio galaxies, but they are on average a factor 1.6 less massive. The number density of FR0CAT sources is 5 times higher than that of FR Is, and thus they represent the dominant population of radio sources in the local Universe. Different scenarios are considered to account for the smaller sizes and larger abundance of FR 0s with respect to FR Is. An age-size scenario that considers FR 0s as young radio galaxies that will all eventually evolve into extended radio sources cannot be reconciled with the large space density of FR 0s. However, the radio activity recurrence, with the duration of the active phase covering a wide range of values and with short active periods strongly favored with respect to longer ones, might account for their large density number. Alternatively, the jet properties of FR 0s might be intrinsically different from those of the FR Is, the former class having lower bulk Lorentz factors, possibly due to lower black hole spins. Our study indicates that FR 0s and FR I/IIs can be interpreted as two extremes of a continuous population of radio sources that is characterized by a broad distribution of sizes and luminosities of their extended radio emission, but shares a single class of host galaxies.

76 FR 65653 - New Source Performance Standards (NSPS) Review

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-24

..., PM 2.5 , PM 10 ), nitrogen oxides (NO X ), carbon monoxide (CO), lead (Pb), volatile organic... Refineries Ja 06/24/2008 (73FR35867) 12/22/2008 \\4\\ (73FR78552) (Stay) Phosphate Fertilizers--Diammonium V 08/06/1975 (40FR33155) 10/17/2000 3 4 (65FR61757) Phosphate Plants. Phosphate Fertilizers--Granular X 08...

77 FR 3495 - Endangered Species; Marine Mammals; Issuance of Permits

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-24

... FR 12255, March 15, April 28, 2010. 2010. 09145A Zoological Society of 75 FR 27814, May 18, June 24, 2010. San Diego. 2010. 13802A Zoological Society of 75 FR 34766, June 18, July 28, 2010. San Diego... 15, 2011. Marine Science Center. 2011. 008519 Zoo Atlanta 75 FR 82409, December March 1, 2011. 30...

75 FR 66762 - Agency Information Collection Activities: Announcement of Board Approval Under Delegated...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-29

... and Salary Surveys. Agency form number: FR 29a,b. OMB control number: 7100-0290. Frequency: FR 29a... independence to determine its employees' salaries and compensation. Individual respondent data are regarded as... jointly. The FR 29b is collected by Board staff. The FR 29a,b collect information on salaries, employee...

78 FR 48712 - Endangered Species; Marine Mammals; Issuance of Permits

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-09

... 78 FR 9725; February 11, June 14, 2013. the University of 2013. Illinois. 675484 Birmingham Zoo, Inc..... 78 FR 16292; March 14, May 1, 2013. 2013. 036218 Brevard Zoo 78 FR 1771; March 22, May 1, 2013. 2013... 1771; March 22, May 1, 2013. 2013. 678968 Mesker Park Zoo......... 78 FR 1771; March 22, May 1, 2013...

77 FR 26777 - Endangered Species; Marine Mammals; Issuance of Permits

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-07

.... 47878A Nicole Smolensky... 76 FR 57757; November 15, 2011. September 16, 2011. 56912A Nashville Zoo...... 76 FR 72434; March 12, 2012. November 23, 2011. 50819A San Diego Zoo 76 FR 77006; March 12, 2012.... Ranch. 17, 2012. 697763 Houston Zoo, Inc... 77 FR 2314; January March 9, 2012. 17, 2012. 62113A...

77 FR 300 - Endangered Species; Marine Mammals; Issuance of Permits

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-04

... Angeles Zoo and 76 FR 60862; September November 23, 2011. Botanical Gardens. 30, 2011. 56760A Los Angeles Zoo and 76 FR 66954; October December 1, 2011. Botanical Gardens. 28, 2011. 57442A Matthew Bindon 76 FR 66954; October December 5, 2011. 28, 2011. 54123A Maryland Zoo in 76 FR 71069; November December...

40 CFR 302.6 - Notification requirements.

Code of Federal Regulations, 2012 CFR

2012-07-01

... RQ of solid particles of antimony, arsenic, beryllium, cadmium, chromium, copper, lead, nickel.... 14, 1989; 63 FR 13475, Mar. 19, 1998; 63 FR 42189, Aug. 6, 1998; 64 FR 13114, Mar. 17, 1999; 65 FR...

40 CFR 302.6 - Notification requirements.

Code of Federal Regulations, 2014 CFR

2014-07-01

... RQ of solid particles of antimony, arsenic, beryllium, cadmium, chromium, copper, lead, nickel.... 14, 1989; 63 FR 13475, Mar. 19, 1998; 63 FR 42189, Aug. 6, 1998; 64 FR 13114, Mar. 17, 1999; 65 FR...

40 CFR 302.6 - Notification requirements.

Code of Federal Regulations, 2013 CFR

2013-07-01

... RQ of solid particles of antimony, arsenic, beryllium, cadmium, chromium, copper, lead, nickel.... 14, 1989; 63 FR 13475, Mar. 19, 1998; 63 FR 42189, Aug. 6, 1998; 64 FR 13114, Mar. 17, 1999; 65 FR...

Endoscopic ultrasound-guided biliary drainage using a newly designed metal stent with a thin delivery system: a preclinical study in phantom and porcine models.

PubMed

Minaga, Kosuke; Kitano, Masayuki; Itonaga, Masahiro; Imai, Hajime; Miyata, Takeshi; Yamao, Kentaro; Tamura, Takashi; Nuta, Junya; Warigaya, Kenji; Kudo, Masatoshi

2017-12-08

This study was designed to evaluate the feasibility and safety of a newly designed self-expandable metal stent for endoscopic ultrasound-guided biliary drainage (EUS-BD) when it was delivered via three different stent delivery systems: a 7.5Fr delivery catheter with a bullet-shaped tip (7.5Fr-bullet), a 7Fr catheter with a bullet-shaped tip (7Fr-bullet), or a 7Fr catheter with a tee-shaped tip (7Fr-tee). This experimental study utilized a porcine model of biliary dilatation involving ten pigs. In the animal study, technical feasibility and clinical outcomes of the stent when placed with each of the delivery systems were examined. In addition, a phantom model was used to measure the resistance of these delivery systems to advancement. Phantom experiments showed that, compared with 7Fr-bullet, 7Fr-tee had less resistance force to the advancement of the stent delivery system. EUS-BD was technically successful in all ten pigs. Fistulous tract dilation was necessary in 100% (2/2), 75% (3/4), and 0% (0/4) of the pigs that underwent EUS-BD using 7.5Fr-bullet, 7Fr-bullet, and 7Fr-tee, respectively. There were no procedure-related complications. Our newly designed metal stent may be feasible and safe for EUS-BD, particularly when delivered by 7Fr-tee, because it eliminates the need for fistulous tract dilation.

Stimulatory Effect of Food Restriction on the Steroidogenesis of Aldosterone in Ovariectomized Rats.

PubMed

Kau, Mei-Mei; Yu, Ching-Han; Tsai, Shiow-Chwen; Wang, Jiing-Rong; Wang, Paulus S.

2017-04-30

Food or calorie restriction (FR or CR) induces several physiological changes including weight loss, metabolic adaptations, mineral and hormonal changes. However, the effects of FR on aldosterone steroidogenesis in zona glomerulosa (ZG) cells have not been elucidated. Therefore, the present study was designed to investigate the effects of FR on aldosterone secretion and the involved mechanisms in ovariectomized (Ovx) rats. Ovx rats were divided into ad libitum fed (control) and FR groups. The FR rats exhibited decreased body weight, water intake, urine flow, sodium excretion and increased plasma aldosterone in comparison with control rats. FR elevated the basal and angiotensin II-stimulated aldosterone secretion from ZG cells. The conversions of 25-hydroxy-cholesterol to pregnenolone or corticosterone to aldosterone in ZG cells of FR group were greater than that in control group. FR group had a higher protein expression of steroidogenic acute regulatory (StAR) protein in ZG cells. However, there was no different protein expression of cytochrome P450 sidechain cleavage enzyme (P450scc) in ZG cells between control and FR groups. In summary, the increased activities of P450scc and aldosterone synthase as well as the protein expression of StAR protein in ZG cells are involved in the effects of FR on aldosterone steroidogenesis in Ovx rats. We also suggest that the increase of aldosterone might be associated with anti-diuresis and antinatriuresis in FR group. These results are helpful for understanding the role of aldosterone in physiological adaptation and renal sodium conservation during FR.

Facilitation of the flexor reflex in the cat by intrathecal injection of catecholamines

PubMed Central

Dhawan, B. N.; Sharma, J. N.

1970-01-01

1. Effects of some α- and β-adrenoceptor stimulants and antagonists were investigated on flexor reflex (FR) in chloralosed cats. 2. Noradrenaline (NA) produced facilitation of FR which was dose-dependent and reproducible and was blocked by α-adrenoceptor blocking agents. 3. Strychnine also produced facilitation of FR but the response was unaffected by α-adrenoceptor blocking agents. 4. Metaraminol and α-methyl-noradrenaline had little effect on FR but blocked the NA response. 5. β-adrenoceptor stimulants and antagonists had neither any effect on FR nor modified the NA response. 6. Vasopressin and histamine also failed to modify FR. 7. Possibility of α-adrenoceptors in the neurones integrating FR is suggested. PMID:4395376

40 CFR 61.01 - Lists of pollutants and applicability of part 61.

Code of Federal Regulations, 2012 CFR

2012-07-01

...; June 10, 1985) Methylene Chloride (50 FR 42037; Oct. 17, 1985) Nickel (51 FR 34135; Sept. 25, 1986... Chloride (40 FR 59532; Dec. 24, 1975) (b) The following list presents other substances for which a Federal...) Vinylidene Chloride (50 FR 32632; Aug. 13, 1985) Zinc and Zinc Oxide (52 FR 32597, Aug. 28, 1987) (c) This...

40 CFR 61.01 - Lists of pollutants and applicability of part 61.

Code of Federal Regulations, 2013 CFR

2013-07-01

...; June 10, 1985) Methylene Chloride (50 FR 42037; Oct. 17, 1985) Nickel (51 FR 34135; Sept. 25, 1986... Chloride (40 FR 59532; Dec. 24, 1975) (b) The following list presents other substances for which a Federal...) Vinylidene Chloride (50 FR 32632; Aug. 13, 1985) Zinc and Zinc Oxide (52 FR 32597, Aug. 28, 1987) (c) This...

40 CFR 61.01 - Lists of pollutants and applicability of part 61.

Code of Federal Regulations, 2014 CFR

2014-07-01

...; June 10, 1985) Methylene Chloride (50 FR 42037; Oct. 17, 1985) Nickel (51 FR 34135; Sept. 25, 1986... Chloride (40 FR 59532; Dec. 24, 1975) (b) The following list presents other substances for which a Federal...) Vinylidene Chloride (50 FR 32632; Aug. 13, 1985) Zinc and Zinc Oxide (52 FR 32597, Aug. 28, 1987) (c) This...

77 FR 17477 - Agency Information Collection Activities: Announcement of Board Approval Under Delegated...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-26

..., revised, or implemented on or after October 1, 1995, unless it displays a currently valid OMB control... Building, Room 10235, 725 17th Street NW., Washington, DC 20503. Final approval under OMB delegated... response: FR 2028A, 3.6 hours; FR 2028B, 1.4 hours; and FR 2028S, 0.1 hours. Number of respondents: FR...

47 CFR 0.41 - Functions of the Office.

Code of Federal Regulations, 2011 CFR

2011-10-01

... from the public and others. (Secs. 2, 3, 4, 5, 301, 303, 307, 308, 309, 315, 317, 48 Stat., as amended..., 303, 307, 308, 309, 315, 317) [28 FR 12392, Nov. 22, 1963; 37 FR 19372, Sept. 20, 1972, as amended at...; 62 FR 15853, Apr. 3, 1997; 64 FR 5950, Feb. 8, 1999; 64 FR 57585, Oct. 26, 1999] International Bureau ...

47 CFR 0.41 - Functions of the Office.

Code of Federal Regulations, 2013 CFR

2013-10-01

... from the public and others. (Secs. 2, 3, 4, 5, 301, 303, 307, 308, 309, 315, 317, 48 Stat., as amended..., 303, 307, 308, 309, 315, 317) [28 FR 12392, Nov. 22, 1963; 37 FR 19372, Sept. 20, 1972, as amended at...; 62 FR 15853, Apr. 3, 1997; 64 FR 5950, Feb. 8, 1999; 64 FR 57585, Oct. 26, 1999] International Bureau ...

47 CFR 0.41 - Functions of the Office.

Code of Federal Regulations, 2012 CFR

2012-10-01

... from the public and others. (Secs. 2, 3, 4, 5, 301, 303, 307, 308, 309, 315, 317, 48 Stat., as amended..., 303, 307, 308, 309, 315, 317) [28 FR 12392, Nov. 22, 1963; 37 FR 19372, Sept. 20, 1972, as amended at...; 62 FR 15853, Apr. 3, 1997; 64 FR 5950, Feb. 8, 1999; 64 FR 57585, Oct. 26, 1999] International Bureau ...

47 CFR 0.41 - Functions of the Office.

Code of Federal Regulations, 2014 CFR

2014-10-01

... from the public and others. (Secs. 2, 3, 4, 5, 301, 303, 307, 308, 309, 315, 317, 48 Stat., as amended..., 303, 307, 308, 309, 315, 317) [28 FR 12392, Nov. 22, 1963; 37 FR 19372, Sept. 20, 1972, as amended at...; 62 FR 15853, Apr. 3, 1997; 64 FR 5950, Feb. 8, 1999; 64 FR 57585, Oct. 26, 1999] International Bureau ...

7 CFR 301.53-3 - Quarantined areas.

Code of Federal Regulations, 2013 CFR

2013-01-01

..., Alpena, Antrim, Arenac, Barry, Bay, Benzie, Berrien, Branch, Calhoun, Cass, Charlevoix, Cheboygan, Clare.... 3, 2005; 70 FR 62231, Oct. 31, 2005; 71 FR 29764, May 24, 2006; 71 FR 57873, Oct. 2, 2006; 72 FR...

7 CFR 301.53-3 - Quarantined areas.

Code of Federal Regulations, 2012 CFR

2012-01-01

..., Alpena, Antrim, Arenac, Barry, Bay, Benzie, Berrien, Branch, Calhoun, Cass, Charlevoix, Cheboygan, Clare.... 3, 2005; 70 FR 62231, Oct. 31, 2005; 71 FR 29764, May 24, 2006; 71 FR 57873, Oct. 2, 2006; 72 FR...

7 CFR 301.53-3 - Quarantined areas.

Code of Federal Regulations, 2011 CFR

2011-01-01

..., Alpena, Antrim, Arenac, Barry, Bay, Benzie, Berrien, Branch, Calhoun, Cass, Charlevoix, Cheboygan, Clare.... 3, 2005; 70 FR 62231, Oct. 31, 2005; 71 FR 29764, May 24, 2006; 71 FR 57873, Oct. 2, 2006; 72 FR...

7 CFR 301.53-3 - Quarantined areas.

Code of Federal Regulations, 2014 CFR

2014-01-01

..., Alpena, Antrim, Arenac, Barry, Bay, Benzie, Berrien, Branch, Calhoun, Cass, Charlevoix, Cheboygan, Clare.... 3, 2005; 70 FR 62231, Oct. 31, 2005; 71 FR 29764, May 24, 2006; 71 FR 57873, Oct. 2, 2006; 72 FR...

Large-scale magnetic topologies of mid M dwarfs

NASA Astrophysics Data System (ADS)

Morin, J.; Donati, J.-F.; Petit, P.; Delfosse, X.; Forveille, T.; Albert, L.; Aurière, M.; Cabanac, R.; Dintrans, B.; Fares, R.; Gastine, T.; Jardine, M. M.; Lignières, F.; Paletou, F.; Ramirez Velez, J. C.; Théado, S.

2008-10-01

We present in this paper, the first results of a spectropolarimetric analysis of a small sample (~20) of active stars ranging from spectral type M0 to M8, which are either fully convective or possess a very small radiative core. This study aims at providing new constraints on dynamo processes in fully convective stars. This paper focuses on five stars of spectral type ~M4, i.e. with masses close to the full convection threshold (~=0.35Msolar), and with short rotational periods. Tomographic imaging techniques allow us to reconstruct the surface magnetic topologies from the rotationally modulated time-series of circularly polarized profiles. We find that all stars host mainly axisymmetric large-scale poloidal fields. Three stars were observed at two different epochs separated by ~1 yr; we find the magnetic topologies to be globally stable on this time-scale. We also provide an accurate estimation of the rotational period of all stars, thus allowing us to start studying how rotation impacts the large-scale magnetic field. Based on observations obtained at the Canada-France-Hawaii Telescope (CFHT) and the Télescope Bernard Lyot (TBL). CFHT is operated by the National Research Council of Canada, the Institut National des Science de l'Univers of the Centre National de la Recherche Scientifique of France (INSU/CNRS) and the University of Hawaii, while the TBL is operated by CNRS/INSU. E-mail: jmorin@ast.obs-mip.fr (JM); donati@ast.obs-mip.fr (J-FD); petit@ast.obs-mip.fr (PP); xavier.delfosse@obs.ujf-grenoble.fr (XD); thierry.forveille@obs.ujf-grenoble.fr (TF); albert@cfht.hawaii.edu (LA); auriere@ast.obs-mip.fr (MA); remi.cabanac@ast.obs-mip.fr (RC); dintrans@ast.obs-mip.fr (BD); rfares@ast.obs-mip.fr (RF); tgastine@ast.obs-mip.fr (TG); mmj@st-andrews.ac.uk (MMJ); ligniere@ast.obs-mip.fr (FL); fpaletou@ast.obs-mip.fr (FP); jramirez@mesiog.obspm.fr (JR); sylvie.theado@ast.obs-mip.fr (ST)

40 CFR 52.2120 - Identification of plan.

Code of Federal Regulations, 2013 CFR

2013-07-01

... II Sulfuric Acid Manufacturing 2/28/1986 2/17/1987 52 FR 4772 Section III Kraft Pulp and Paper.../1987 52 FR 4772 Section V Cotton Gins 10/26/2001 5/7/2002 67 FR 30594 Section VI Hot Mix Asphalt.../1990 2/4/1992 57 FR 4158 Part C Surface Coating of Paper, Vinyl, and Fabric 8/24/1990 2/4/1992 57 FR...

40 CFR 52.2120 - Identification of plan.

Code of Federal Regulations, 2014 CFR

2014-07-01

... II Sulfuric Acid Manufacturing 2/28/1986 2/17/1987 52 FR 4772 Section III Kraft Pulp and Paper.../1987 52 FR 4772 Section V Cotton Gins 10/26/2001 5/7/2002 67 FR 30594 Section VI Hot Mix Asphalt.../1990 2/4/1992 57 FR 4158 Part C Surface Coating of Paper, Vinyl, and Fabric 8/24/1990 2/4/1992 57 FR...

40 CFR 52.2120 - Identification of plan.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Section II Sulfuric Acid Manufacturing 2/28/1986 2/17/1987 52 FR 4772 Section III Kraft Pulp and Paper.../1987 52 FR 4772 Section V Cotton Gins 10/26/2001 5/7/2002 67 FR 30594 Section VI Hot Mix Asphalt.../1990 2/4/1992 57 FR 4158 Part C Surface Coating of Paper, Vinyl, and Fabric 8/24/1990 2/4/1992 57 FR...

11 CFR 102.2 - Statement of organization: Forms and committee identification number (2 U.S.C. 433 (b), (c)).

Code of Federal Regulations, 2010 CFR

2010-01-01

... boxes, or other depositories used by the committee; (vii) The Internet address of the committee's... on all communications concerning reports and statements. [45 FR 15104, Mar. 7, 1980, as amended at 50 FR 50778, Dec. 12, 1985; 54 FR 34109, Aug. 17, 1989; 54 FR 48580, Nov. 24, 1989; 58 FR 42173, Aug. 6...

40 CFR 52.520 - Identification of plan.

Code of Federal Regulations, 2014 CFR

2014-07-01

... FR 52916 62-210.700 Excess Emissions 11/23/94 6/16/9964 FR 32346 62-210.900 Forms and Instructions 2/9/93 11/7/9459 FR 46157 62-210.920 Air General Permit Forms 5/9/2007 6/1/200963 FR 26103 Chapter 62... 13883 62-252.900 Form 2/2/93 7/21/9762 FR 38918 Chapter 62-256 Open Burning and Frost Protection Fires...

78 FR 33860 - Workforce Investment Act of 1998 (WIA); Notice of Incentive Funding Availability Based on Program...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-05

... Administration published a document in the Federal Register of May 24, 2013, notifying eligible state grantees of... Murren, 202-693-3733. Corrections In the Federal Register of May 24, 2013, in FR Doc. 78 FR 31596, on...''. In the Federal Register of May 24, 2013, in FR Doc. 78 FR 31596, on page 31597, in the first column...

An RGDS peptide-binding receptor, FR-1R, localizes to the basal side of the ectoderm and to primary mesenchyme cells in sand dollar embryos.

PubMed

Katow, H; Sofuku, S

2001-10-01

Immunoblotting using polyclonal antibodies (pAb) raised against an FR-1 receptor (FR-1R), a 57 kDa Arg-Gly-Asp-Ser (RGDS)-binding protein, of the sand dollar Clypeaster japonicus showed that the pAb monospecifically bound to the protein. FR-1R was present in purified plasma membrane, suggesting that the protein is a membrane-bound protein. The molecular structure of FR-1R did not change throughout the early embryogenesis, whereas its expression changed significantly during this period. FR-1R was present in the cortex of unfertilized eggs and was then transferred to the hyaline layer soon after the fertilization. The hyaline layer retained FR-1R immunoreactivity during early embryogenesis. FR-1R appeared on the basal side of the ectoderm at the morula stage and was retained basolaterally, at least, to the early gastrula stage. In mesenchyme blastulae, FR-1R was also present on the surface of primary mesenchyme cells (PMC). FR-1R was localized on the basal side of the ectoderm in early gastrulae, exclusively at the place where PMC formed ventrolateral aggregates, and at the apical tuft ectoderm. In vitro, PMC bound to FR-1R and its binding was inhibited in the presence of a synthetic RGDS peptide or the pAb. The pAb introduced into the blastocoele perturbed PMC migration and gastrulation. FR-1R was weakly recognized by antihuman integrin beta5 subunit pAb.

76 FR 32222 - Endangered Species; Marine Mammals; Issuance of Permits

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-03

... Zoological Society of 76 FR 2408; January March 10, 2011. San Diego. 13, 2011. 27787A Virginia Aquarium & 76 FR 2408; January February 15, 2011. Marine Science 13, 2011. Center. 26030A Drexel University, 75 FR...

47 CFR 73.681 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

...Hz and 120 kHz to convey information or that encodes digital information in the video portion of the...; 47 FR 35990, Aug. 18, 1982; 49 FR 18106, Apr. 27, 1984; 49 FR 38131, Sept. 27, 1984; 49 FR 50048, Dec...

33 CFR 165.1107 - San Diego Bay, California.

Code of Federal Regulations, 2010 CFR

2010-07-01

...)(1). [CGD11-90-07, 56 FR 14645, Apr. 11, 1991; 56 FR 40360, Aug. 14, 1991, as amended by USCG-1998-3799, 63 FR 35533, June 30, 1998. Redesignated by USCG-2001-9286, 66 FR 33642, June 25, 2001] ...

33 CFR 165.1107 - San Diego Bay, California.

Code of Federal Regulations, 2011 CFR

2011-07-01

...)(1). [CGD11-90-07, 56 FR 14645, Apr. 11, 1991; 56 FR 40360, Aug. 14, 1991, as amended by USCG-1998-3799, 63 FR 35533, June 30, 1998. Redesignated by USCG-2001-9286, 66 FR 33642, June 25, 2001] ...

78 FR 12780 - Endangered Species; Marine Mammals; Issuance of Permits

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-25

... Moore 77 FR 66476; January 14, 2013. November 5, 2012. 84872A Palm Beach Zoo at 77FR 66476; November... Islands November 16, 2012. Regional Office. 89103A Dallas Zoo 77FR 68809; November February 12, 2013. 16...

75 FR 17947 - Endangered and Threatened Wildlife and Plants; 5-Year Status Reviews of 69 Species in Idaho...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-08

..., [Unnamed] Drosophila aglaia...... E U.S.A. (HI) 71 FR 26835; 5/9/2006. Pomace fly, [Unnamed] Drosophila differens... E U.S.A. (HI) 71 FR 26835; 5/9/2006. Pomace fly, [Unnamed] Drosophila hemipeza.... E U.S.A. (HI) 71 FR 26835; 5/9/2006. Pomace fly, [Unnamed] Drosophila heteroneura. E U.S.A. (HI) 71 FR 26835; 5/9...

27 CFR 28.65 - Bond, Form 2738 (5110.68).

Code of Federal Regulations, 2010 CFR

2010-04-01

... as provided in § 28.171(d) and the terms of his bond on Form 2738 (5110.68), then in force, do not..., 5066) [T.D. 7112, 36 FR 8580, May 8, 1971. Redesignated at 40 FR 16835, Apr. 15, 1975, and amended by T.D. ATF-62, 44 FR 71721, Dec. 11, 1979; T.D. ATF-198, 50 FR 8559, Mar. 1, 1985; T.D. TTB-8, 69 FR...

27 CFR 28.65 - Bond, Form 2738 (5110.68).

Code of Federal Regulations, 2011 CFR

2011-04-01

... as provided in § 28.171(d) and the terms of his bond on Form 2738 (5110.68), then in force, do not..., 5066) [T.D. 7112, 36 FR 8580, May 8, 1971. Redesignated at 40 FR 16835, Apr. 15, 1975, and amended by T.D. ATF-62, 44 FR 71721, Dec. 11, 1979; T.D. ATF-198, 50 FR 8559, Mar. 1, 1985; T.D. TTB-8, 69 FR...

40 CFR 52.520 - Identification of plan.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 52916 62-210.700 Excess Emissions 11/23/94 6/16/9964 FR 32346 62-210.900 Forms and Instructions 2/9/93 11/7/9459 FR 46157 62-210.920 Air General Permit Forms 9/4/2006 06/01/0974 FR 26103 Chapter 62-212... Tanker Trucks 9/4/2006 06/01/0974 FR 26103 62-252.800 Penalties 2/2/93 3/24/9459 FR 13883 62-252.900 Form...

40 CFR 52.520 - Identification of plan.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Excess Emissions 11/23/94 6/16/9964 FR 32346 62-210.900 Forms and Instructions 2/9/93 11/7/9459 FR 46157 62-210.920 Air General Permit Forms 9/4/2006 06/01/0974 FR 26103 Chapter 62-212 Stationary Souces... 2/2/93 3/24/9459 FR 13883 62-252.900 Form 2/2/93 7/21/9762 FR 38918 Chapter 62-256Open Burning and...

Dirac Quasinormal Modes of Static f(R) de Sitter Black Holes

NASA Astrophysics Data System (ADS)

Ma, Hong

2018-02-01

Quasinormal modes (QNMs) for Dirac perturbations of f(R) black holes (BHs) are described in this paper, involving two types of f(R) solution: f(R) (Schwarzschild) BHs and f(R) (Maxwell) BHs. With the finite difference method, the stability of the f(R) black holes (BHs) is analysed and the threshold range of f(R) (Schwarzschild) BHs and f(R) (Maxwell) BHs is defined respectively. The results show that due to the presence of the correction factor R0, the damping rate of Dirac field decreases. Meanwhile, the influence of angular quantum number values |k| on the f(R) BHs is investigated. The results indicate that the QNMs oscillation becomes tenser and damping speed slowly decreases with |k| increasing. Furthermore, under the Dirac perturbation, the stability of f(R) solutions can be reflected in the manner of Dirac QNMs. The relationships between the QNMs and the parameters (|k|, charge Q and mass m) are discussed in massless, and massive cases, by contrast to the classical BHs. Supported by FAPESP No. 2012/08934-0, National Natural Science Foundation of China under Grant Nos. 11205254, 11178018, 11375279, 11605015, and the Natural Science Foundation Project of CQ CSTC 2011BB0052, and the Fundamental Research Funds for the Central Universities 106112016CDJXY300002 and CDJRC10300003

PREFACE: Nanosafe 2012: International Conferences on Safe Production and Use of Nanomaterials

NASA Astrophysics Data System (ADS)

Tardif, François

2013-04-01

Welcome from the organizers The rapidly developing field of nanotechnology opens up many exciting opportunities and benefits for new materials with significantly improved properties as well as some revolutionary applications in the fields of energy, environment, medicine, etc. These new materials potentially pave the way to considerable innovations in many industries of the 21st century although associated risks must be perfectly under control for workers, consumers and the environment. So, one can easily understand why Nanosafety is now considered as a specific new scientific area, gaining in importance and maturity every day. Following the successful outcome of the two past international conferences on the safe production and use of nanomaterials: Nanosafe 2008 and 2010, the organizing committee has the pleasure of welcoming again to Grenoble some of the most famous specialists of the field in the world. In addition to the standard issues addressed in previous nanosafe conferences such as Toxicology, Eco-toxicology, Expology, Detection, Life Cycle Analysis, Regulation and Standardization, new topics of great interest will be dealt with this year, concerning Governance and practical Risk Management for OSH experts and Societal issues. In order to enhance the exchanges and conviviality three debates werw organized around Nano Governance, Toxicology and Ethics. We hope that you will appreciate this new Nanosafe edition like the previous ones. This is your Nanosafe conference, please enjoy. The Nanosafe conference organisers François Tardif and Frédéric Shuster Management Vanessa Gaultier Francois TardifFrederic ShusterVanessa Gaultier François TardifFrédéric Shuster Vanessa Gaultier Local Organizing Committee Vanessa GAULTIER (CEA) François TARDIF (CEA) Dominique BAGUET (CEA) Frédédric SHUSTER (CEA) Yves SICARD (CEA) Catherine DURAND (CEA) Didier MOLKO (MINATEC) International Scientific Committee Chair: Frédéric SCHUSTER (CEA, FR) François TARDIF (CEA, FR) Co-chair: Georgios KATALAGARIANAKIS (EC, BE) Mélanie AUFFAN (CEREGE, FR) Jorge BOCZKOWSKI (INSERM, FR) Jean-Yves BOTTERO (CEREGE, FR) Jacques BOUILLARD (INERIS, FR) Derk BROUWER (TNO, NL) Marie CARRIERE (CEA, FR) Claude EMOND (U. MONTREAL, CA) Cassandra ENGEMAN (UCSB, USA) Eric GAFFET (CNRS, FR) François GENSDARMES (IRSN, FR) Alexei GRINBAUM (CEA, FR) Antje GROBE (U.STUTTGART, DE) Peter HOET (KUL, BE) Eric QUEMENEUR (CEA, FR) Olivier LE BIHAN (INERIS, FR) Robert MUIR (NANEUM, UK) Tinh NGUYEN (NIST, USA) Bernd NOWACK (EMPA, CH) Günter OBERDÖRSTER (U. ROCHESTER, USA) David PUI (U. MINNESOTA, USA) Michael RIEDIKER (IST, CH) Yves SAMSON (CEA, FR) Ken TAKEDA (U. TOKYO, JP) Olivier WITSCHGER (INRS, FR) The PDF contains a list of sponsor logos, the conference programme and planning documents.

Interaction between behavioral and pharmacological treatment strategies to decrease cocaine choice in rhesus monkeys.

PubMed

Banks, Matthew L; Blough, Bruce E; Negus, S Stevens

2013-02-01

Behavioral and pharmacotherapeutic approaches constitute two prominent strategies for treating cocaine dependence. This study investigated interactions between behavioral and pharmacological strategies in a preclinical model of cocaine vs food choice. Six rhesus monkeys, implanted with a chronic indwelling double-lumen venous catheter, initially responded under a concurrent schedule of food delivery (1-g pellets, fixed-ratio (FR) 100 schedule) and cocaine injections (0-0.1 mg/kg/injection, FR 10 schedule) during continuous 7-day treatment periods with saline or the agonist medication phenmetrazine (0.032-0.1 mg/kg/h). Subsequently, the FR response requirement for cocaine or food was varied (food, FR 100; cocaine, FR 1-100; cocaine, FR 10; food, FR 10-300), and effects of phenmetrazine on cocaine vs food choice were redetermined. Decreases in the cocaine FR or increases in the food FR resulted in leftward shifts in the cocaine choice dose-effect curve, whereas increases in the cocaine FR or decreases in the food FR resulted in rightward shifts in the cocaine choice dose-effect curve. The efficacy of phenmetrazine to decrease cocaine choice varied systematically as a function of the prevailing response requirements, such that phenmetrazine efficacy was greatest when cocaine choice was maintained by relatively low unit cocaine doses. These results suggest that efficacy of pharmacotherapies to modulate cocaine use can be influenced by behavioral contingencies of cocaine availability. Agonist medications may be most effective under contingencies that engender choice of relatively low cocaine doses.

33 CFR 117.881 - John Day River.

Code of Federal Regulations, 2010 CFR

2010-07-01

... below Bonneville Dam. [CGD 82-025, 49 FR 17452, Apr. 24, 1984, as amended by CGD13 91-07, 56 FR 67528, Dec. 31, 1991; USCG-2000-7223, 65 FR 40056, June 29, 2000; USCG-2001-10881, 71 FR 70312, Dec. 4, 2006] ...

33 CFR 117.881 - John Day River.

Code of Federal Regulations, 2011 CFR

2011-07-01

... below Bonneville Dam. [CGD 82-025, 49 FR 17452, Apr. 24, 1984, as amended by CGD13 91-07, 56 FR 67528, Dec. 31, 1991; USCG-2000-7223, 65 FR 40056, June 29, 2000; USCG-2001-10881, 71 FR 70312, Dec. 4, 2006] ...

77 FR 71192 - Agency Information Collection Activities: Announcement of Board Approval Under Delegated...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-29

..., Report of Changes in Organizational Structure, and FR Y-6, Annual Report of Holding Companies (OMB No... the FR Y-10 and FR Y-6 is not appropriately tailored for DFMUs, and structure data with respect to...

49 CFR 385.17 - Change to safety rating based upon corrective actions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... in CMVs or placardable quantities of hazardous materials. (2) Within 45 days for all other motor.... [65 FR 50935, Aug. 22, 2000, as amended at 72 FR 36788, July 5, 2007; 75 FR 17241, Apr. 5, 2010; 77 FR...

49 CFR 385.17 - Change to safety rating based upon corrective actions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... in CMVs or placardable quantities of hazardous materials. (2) Within 45 days for all other motor.... [65 FR 50935, Aug. 22, 2000, as amended at 72 FR 36788, July 5, 2007; 75 FR 17241, Apr. 5, 2010; 77 FR...

Morphology, Spatial Distribution, and Concentration of Flame Retardants in Consumer Products and Environmental Dusts using Scanning Electron Microscopy and Raman Micro-spectroscopy

PubMed Central

WAGNER, JEFF; GHOSAL, SUTAPA; WHITEHEAD, TODD; METAYER, CATHERINE

2013-01-01

We characterized flame retardant (FR) morphologies and spatial distributions in 7 consumer products and 7 environmental dusts to determine their implications for transfer mechanisms, human exposure, and the reproducibility of gas chromatography-mass spectrometry (GC-MS) dust measurements. We characterized individual particles using scanning electron microscopy / energy dispersive x-ray spectroscopy (SEM/EDS) and Raman micro-spectroscopy (RMS). Samples were screened for the presence of 3 FR constituents (bromine, phosphorous, non-salt chlorine) and 2 metal synergists (antimony and bismuth). Subsequent analyses of select samples by RMS enabled molecular identification of the FR compounds and matrix materials. The consumer products and dust samples possessed FR elemental weight percents of up to 36% and 31%, respectively. We identified 24 FR-containing particles in the dust samples and classified them into 9 types based on morphology and composition. We observed a broad range of morphologies for these FR-containing particles, suggesting FR transfer to dust via multiple mechanisms. We developed an equation to describe the heterogeneity of FR-containing particles in environmental dust samples. The number of individual FR-containing particles expected in a 1-mg dust sample with a FR concentration of 100 ppm ranged from <1 to >1000 particles. The presence of rare, high-concentration bromine particles was correlated with decabromodiphenyl ether concentrations obtained via GC-MS. When FRs are distributed heterogeneously in highly concentrated dust particles, human exposure to FRs may be characterized by high transient exposures interspersed by periods of low exposure, and GC-MS FR concentrations may exhibit large variability in replicate subsamples. Current limitations of this SEM/EDS technique include potential false negatives for volatile and chlorinated FRs and greater quantitation uncertainty for brominated FR in aluminum-rich matrices. PMID:23739093

Simple and easy assessment of falling risk in the elderly by functional reach test using elastic stick.

PubMed

Demura, Shin-Ichi; Yamada, Takayoshi

2007-10-01

Dynamic balance ability related to maintaining postural stability during movement is closely tied to fall risk in the elderly. The functional reach (FR) test has been developed to evaluate their dynamic balance. Although a simple and new FR test using an elastic stick has been proposed by modifying the above original FR test, the abilities related to both FR tests are judged to differ because of the large difference in the testing method. This study aimed to compare center of gravity fluctuation, muscle activity and functional reach distance as measured by the original FR test and the elastic stick FR test. First, reach distance, back/forth and right/left moving distance of the center of gravity, and activity of the lower leg muscles (soleus and tibialis anterior) were compared between both tests based on data obtained from 30 young male adults. All parameters except for the right/left moving distance were significantly larger in the elastic stick FR test. Next, the reach distance was examined in both FR tests using 53 elderly subjects; it was significantly longer in the elastic stick FR test, but showed no significant sex difference. The reach distance in both tests was significantly shorter (about 7 cm) in the elderly than in young adults. In conclusion, the elastic stick FR test involves greater leg muscle strength exertion and forward transferring of the center of gravity as compared with the original FR test. Because the elastic stick FR test relates largely to leg muscle function and equilibrium function, it may be more useful for evaluating the dynamic balance ability of the elderly.

40 CFR 52.50 - Identification of plan.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Coating 10/15/96 6/6/97; 62 FR 30991 Section 335-3-6-.12 Solvent Metal Cleaning 10/15/96 06/6/97; 62 FR... Synthesized Pharmaceutical Products 10/15/96 6/6/97; 62 FR 30991 Section 335-3-6-.19 Reserved Section 335-3-6... Sources 6/22/89 3/19/90; 55 FR 10062 Section 335-3-6-.32 Surface Coating 10/15/96 6/6/97; 62 FR 30991...

Initial experience with the 3.3 Fr Mongoose® pigtail catheter for aortic angiography during patent ductus arteriosus closure in small patients.

PubMed

Hena, Zachary; Sutton, Nicole J; Gates, Gregory J; Taragin, Benjamin H; Pass, Robert H

2017-01-01

Smaller femoral arterial sheaths may be associated with fewer vascular complications. The 3.3 Fr Mongoose ® Pediavascular pigtail catheter is a catheter that allows higher flow rates, potentially resulting in improved angiographic quality. We reviewed our experience with this small catheter during patent ductus arteriosus (PDA) closure. Review of patients ≤20 kg in whom the Mongoose ® catheter was used during PDA closure from 12/13 to 4/15. Angiographic efficacy and procedural details were compared to ten 4 Fr catheter cases. Comparisons were performed using Mann-Whitney U-test; P < 0.05 was statistically significant. Twelve (9 female) patients were catheterized with a 3.3 Fr Mongoose ® . Median weight 10.5 kg (range 6.4-18.2), height 81 cm (range 37-111), and body surface area (BSA) 0.47 m 2 (range 0.33-0.75) were similar to ten patients (3 females) in the 4 Fr control group ( P = NS); median weight 9.9 kg (range 6-16.8), height 80 cm (range 64-102), and BSA 0.46 m2 (range 0.31-0.74). Angiographic quality was subjectively adequate with both with no difference in the median pixel density between the two techniques (3.3 Fr: 76.7 [range 33.5-90] and 4 Fr: [70; 38-102]; P = NS). Contrast used was similar between the groups (3.3 Fr: median 4.2 ml/kg and 4 Fr: 4.9 ml/kg; P = NS). Median radiation dose was similar in the two groups (3.3 Fr: 28.1 mGy [range 17.2-38] and 4 Fr: 38 mGy [range 20.4-58.5]; P = NS). All ducts were closed at latest follow-up ( P = NS). No complications were encountered. The 3.3 Fr Mongoose ® allowed similar angiography to the 4 Fr pigtail catheter, allowing safe and effective transcatheter PDA closure in small children.

78 FR 30327 - Endangered Species; Marine Mammals; Issuance of Permits

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-22

.... 15387A Wild Acres Ranch....... 77 FR 26779; May 7, June 20, 2012. 2012. 72654A William Bean 77 FR 26779..., 2012. 2012. 72653A William Bean 77 FR 26779; May 7, June 21, 2012. 2012. 71823A Blex Exchange III, L.P...

"Work ethic" in pigeons: reward value is directly related to the effort or time required to obtain the reward.

PubMed

Clement, T S; Feltus, J R; Kaiser, D H; Zentall, T R

2000-03-01

Stimuli associated with less effort or with shorter delays to reinforcement are generally preferred over those associated with greater effort or longer delays to reinforcement. However, the opposite appears to be true of stimuli that follow greater effort or longer delays. In training, a simple simultaneous discrimination followed a single peck to an initial stimulus (S+FR1 S-FR1) and a different simple simultaneous discrimination followed 20 pecks to the initial stimulus (S+FR20 S-FR20). On test trials, pigeons preferred S+FR20 over S+FR1 and S-FR20 over S-FR1. These data support the view that the state of the animal immediately prior to presentation of the discrimination affects the value of the reinforcement that follows it. This contrast effect is analogous to effects that when they occur in humans have been attributed to more complex cognitive and social factors.

Reconstructing f(R) gravity from a Chaplygin scalar field in de Sitter spacetimes

NASA Astrophysics Data System (ADS)

Sami, Heba; Namane, Neo; Ntahompagaze, Joseph; Elmardi, Maye; Abebe, Amare

We present a reconstruction technique for models of f(R) gravity from the Chaplygin scalar field in flat de Sitter spacetimes. Exploiting the equivalence between f(R) gravity and scalar-tensor (ST) theories, and treating the Chaplygin gas (CG) as a scalar field model in a universe without conventional matter forms, the Lagrangian densities for the f(R) action are derived. Exact f(R) models and corresponding scalar field potentials are obtained for asymptotically de Sitter spacetimes in early and late cosmological expansion histories. It is shown that the reconstructed f(R) models all have General Relativity (GR) as a limiting solution.

76 FR 2721 - Affirmative Decisions on Petitions for Modification Granted in Whole or in Part

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-14

...-2010-004-C FR Notice: 75 FR 12796 March 17, 2010). Petitioner: Jim Walter Resources, Inc., P.O. Box 133... W. Silvey, Certifying Officer. [FR Doc. 2011-686 Filed 1-13-11; 8:45 am] BILLING CODE 4510-43-P ...

76 FR 54717 - Supervised Securities Holding Companies Registration

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-02

... other financial statements submitted to the securities holding company's current consolidated supervisor... Y-9ES), The Supplement to the Consolidated Financial Statements for Bank Holding Companies (FR Y-9CS... Companies (FR Y-6), The Report of Foreign Banking Organizations (FR Y-7), The Consolidated Financial...

78 FR 76738 - Updated Statements of Legal Authority for the Export Administration Regulations

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-19

... 13637 of March 8, 2013, 78 FR 16129 (March 13, 2013), and as extended by the Notice of August 8, 2013.... 5; 22 U.S.C. 7201 et seq.; 22 U.S.C. 7210; E.O. 11912, 41 FR 15825, 3 CFR, 1976 Comp., p. 114; E.O.... 13338, 69 FR 26751, 3 CFR, 2004 Comp., p 168; E.O. 13637 of March 8, 2013, 78 FR 16129 (March 13, 2013...

Deep vein thrombosis using noncontrast-enhanced MR venography with electrocardiographically gated three-dimensional half-Fourier FSE: preliminary experience.

PubMed

Ono, Atsushi; Murase, Kenya; Taniguchi, Toshitaka; Shibutani, Osamu; Takata, Satoru; Kobashi, Yasuyuki; Miyazaki, Mitsue

2009-04-01

Three noncontrast-enhanced MR venography techniques are presented for assessing deep vein thrombosis (DVT) at 0.5 T in patients with metallic implants. Two cardiac-gated 3D half-Fourier FSE fresh blood imaging sequences with flow-refocusing pulses (FR-FBI) in the read-out (RO) direction and without FR pulses (non-FR-FBI) were developed for slower-flowing blood. For faster flowing blood, a swap phase-encode arterial double-subtraction elimination (SPADE) technique was developed. The three techniques were assessed both quantitatively using signal-to-noise (SNR) and contrast-noise-ratio (CNR) measurements and qualitatively by subjective image analysis in 15 volunteers. SPADE was compared to FR-FBI in the pelvic veins and FR-FBI was compared to non-FR-FBI in the thigh and calf veins. Both SPADE and FR-FBI techniques produced significantly higher SNRs, CNRs, and image quality in each comparative study (P<0.001). Five patients with metallic implants and confirmed DVT underwent SPADE (pelvic veins) and FR-FBI (thigh and calf veins) examinations and the results were compared to conventional venography. The SPADE and FR-FBI images showed all DVTs from all five patients without interference from implant susceptibility artifacts. The excellent image quality produced by both SPADE and FR-FBI throughout peripheral vasculature demonstrates their promise for detecting DVT in postsurgery patients.

Relationship between instantaneous wave-free ratio and fractional flow reserve in patients receiving hemodialysis.

PubMed

Morioka, Yuta; Arashi, Hiroyuki; Otsuki, Hisao; Yamaguchi, Junichi; Hagiwara, Nobuhisa

2017-06-22

Instantaneous wave-free ratio (iFR) is a vasodilator-free index and is reported to have a good correlation with fractional flow reserve (FFR). Hemodialysis patients exhibit left ventricular hypertrophy, reduced arterial compliance, and impaired microcirculation. Such a coronary flow condition in these patients may influence the relationship between iFR and FFR. This study assessed the impact of hemodialysis on the relationship between iFR and FFR. The study enrolled 196 patients with 265 stenoses who underwent assessment via iFR, FFR assessment, and right heart catheterization. A good correlation between iFR and FFR was observed in hemodialysis patients. iFR in the hemodialysis group was significantly lower than in the non-hemodialysis group (0.81 ± 0.13 vs. 0.86 ± 0.13, p = 0.005), although no significant difference was found in FFR and percentage diameter stenosis. An iFR value of 0.84 was found to be equivalent to an FFR value of 0.8 in hemodialysis patients, which was lower than the standard predictive iFR range for ischemia. Vasodilator-free assessment by iFR could be beneficial in evaluating intermediate coronary stenosis in patients receiving hemodialysis. However, the threshold for iFR abnormality needs adjustment in hemodialysis patients, and larger clinical trials are required to confirm the results in this specific subset.

Radial force distribution changes associated with tangential force production in cylindrical grasping, and the importance of anatomical registration.

PubMed

Pataky, Todd C; Slota, Gregory P; Latash, Mark L; Zatsiorsky, Vladimir M

2012-01-10

Radial force (F(r)) distributions describe grip force coordination about a cylindrical object. Recent studies have employed only explicit F(r) tasks, and have not normalized for anatomical variance when considering F(r) distributions. The goals of the present study were (i) to explore F(r) during tangential force production tasks, and (ii) to examine the extent to which anatomical registration (i.e. spatial normalization of anatomically analogous structures) could improve signal detectability in F(r) data. Twelve subjects grasped a vertically oriented cylindrical handle (diameter=6 cm) and matched target upward tangential forces of 10, 20, and 30 N. F(r) data were measured using a flexible pressure mat with an angular resolution of 4.8°, and were registered using piecewise-linear interpolation between five manually identified points-of-interest. Results indicate that F(r) was primarily limited to three contact regions: the distal thumb, the distal fingers, and the fingers' metatacarpal heads, and that, while increases in tangential force caused significant increases in F(r) for these regions, they did not significantly affect the F(r) distribution across the hand. Registration was found to substantially reduce between-subject variability, as indicated by both accentuated F(r) trends, and amplification of the test statistic. These results imply that, while subjects focus F(r) primarily on three anatomical regions during cylindrical grasp, inter-subject anatomical differences introduce a variability that, if not corrected for via registration, may compromise one's ability to draw anatomically relevant conclusions from grasping force data. Copyright © 2011 Elsevier Ltd. All rights reserved.

29 CFR 1952.367 - Changes to approved plans.

Code of Federal Regulations, 2010 CFR

2010-07-01

... plans. (a) Legislation. (1) On March 29, 1994, the Assistant Secretary approved New Mexico's revised... Secretary on September 24, 1997. [59 FR 14556, Mar. 29, 1994. Redesignated at 59 FR 42496, Aug. 18, 1994, as amended at 62 FR 49911, Sept. 24, 1997; 67 FR 60129, Sept. 25, 2002] ...

7 CFR 29.3068 - Tannish-red color (FR).

Code of Federal Regulations, 2012 CFR

2012-01-01

... Type 93) § 29.3068 Tannish-red color (FR). A light red shaded toward tan. [24 FR 8771, Oct. 29, 1959... 7 Agriculture 2 2012-01-01 2012-01-01 false Tannish-red color (FR). 29.3068 Section 29.3068 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards...

7 CFR 29.3068 - Tannish-red color (FR).

Code of Federal Regulations, 2011 CFR

2011-01-01

... Type 93) § 29.3068 Tannish-red color (FR). A light red shaded toward tan. [24 FR 8771, Oct. 29, 1959... 7 Agriculture 2 2011-01-01 2011-01-01 false Tannish-red color (FR). 29.3068 Section 29.3068 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards...

7 CFR 29.3068 - Tannish-red color (FR).

Code of Federal Regulations, 2014 CFR

2014-01-01

... Type 93) § 29.3068 Tannish-red color (FR). A light red shaded toward tan. [24 FR 8771, Oct. 29, 1959... 7 Agriculture 2 2014-01-01 2014-01-01 false Tannish-red color (FR). 29.3068 Section 29.3068 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards...

7 CFR 29.3068 - Tannish-red color (FR).

Code of Federal Regulations, 2013 CFR

2013-01-01

... Type 93) § 29.3068 Tannish-red color (FR). A light red shaded toward tan. [24 FR 8771, Oct. 29, 1959... 7 Agriculture 2 2013-01-01 2013-01-01 false Tannish-red color (FR). 29.3068 Section 29.3068 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards...

48 CFR 13.501 - Special documentation requirements.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Special documentation... and complete to the best of the contracting officer's knowledge and belief will serve as approval...; 69 FR 76352, Dec. 20, 2004; 70 FR 57457, Sept. 30, 2005; 71 FR 57360, 57366, Sept. 28, 2006; 75 FR...

48 CFR 13.501 - Special documentation requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Special documentation... and complete to the best of the contracting officer's knowledge and belief will serve as approval...; 69 FR 76352, Dec. 20, 2004; 70 FR 57457, Sept. 30, 2005; 71 FR 57360, 57366, Sept. 28, 2006; 75 FR...

78 FR 76154 - Allocations, Waivers, and Alternative Requirements for Grantees Receiving Community Development...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-16

...://www.gpo.gov/fdsys/pkg/FR-2013-03-05/pdf/2013-05170.pdf http://www.gpo.gov/fdsys/pkg/FR-2013-04-19/pdf/2013-09228.pdf http://www.gpo.gov/fdsys/pkg/FR-2013-08-02/pdf/2013-18643.pdf . For grantees receiving...

76 FR 79063 - Appliance Labeling Rule

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-21

... bulbs (75 FR 41696 (July 19, 2010)), and (2) television labels (76 FR 1038 (Jan. 6, 2011)). The..., 2011, became effective on May 10, 2011, while the earlier light bulb amendments will not become..., instruction 10 and the amendments to Appendix L to Part 305 is removed. Donald S. Clark, Secretary. [FR Doc...

10 CFR 51.45 - Environmental report.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 2 2013-01-01 2013-01-01 false Environmental report. 51.45 Section 51.45 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) ENVIRONMENTAL PROTECTION REGULATIONS FOR DOMESTIC LICENSING AND RELATED... amended at 61 FR 28486, June 5, 1996; 61 FR 66542, Dec. 18, 1996; 68 FR 58810, Oct. 10, 2003; 72 FR 49511...

7 CFR 29.3068 - Tannish-red color (FR).

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Tannish-red color (FR). 29.3068 Section 29.3068 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards... Type 93) § 29.3068 Tannish-red color (FR). A light red shaded toward tan. [24 FR 8771, Oct. 29, 1959...

40 CFR 78.4 - Filings.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 17 2014-07-01 2014-07-01 false Filings. 78.4 Section 78.4 Protection... be made on personal knowledge and belief, set forth only those facts that are admissible into..., Dec. 18, 1997; 69 FR 21645, Apr. 21, 2004; 70 FR 25339, May 12, 2005; 75 FR 75078, Dec. 1, 2010; 76 FR...

40 CFR 78.4 - Filings.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 17 2013-07-01 2013-07-01 false Filings. 78.4 Section 78.4 Protection... be made on personal knowledge and belief, set forth only those facts that are admissible into..., Dec. 18, 1997; 69 FR 21645, Apr. 21, 2004; 70 FR 25339, May 12, 2005; 75 FR 75078, Dec. 1, 2010; 76 FR...

22 CFR 127.12 - Voluntary disclosures.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Voluntary disclosures. 127.12 Section 127.12... the voluntary disclosure are true and correct to the best of that person's knowledge and belief... amended at 70 FR 34655, June 15, 2005; 71 FR 20550, Apr. 21, 2006; 72 FR 70778, Dec. 13, 2007; 77 FR 16642...

22 CFR 127.12 - Voluntary disclosures.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Voluntary disclosures. 127.12 Section 127.12... the voluntary disclosure are true and correct to the best of that person's knowledge and belief... amended at 70 FR 34655, June 15, 2005; 71 FR 20550, Apr. 21, 2006; 72 FR 70778, Dec. 13, 2007; 77 FR 16642...

40 CFR 78.4 - Filings.

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2012-07-01

... 40 Protection of Environment 17 2012-07-01 2012-07-01 false Filings. 78.4 Section 78.4 Protection... be made on personal knowledge and belief, set forth only those facts that are admissible into..., Dec. 18, 1997; 69 FR 21645, Apr. 21, 2004; 70 FR 25339, May 12, 2005; 75 FR 75078, Dec. 1, 2010; 76 FR...

5 CFR 2634.905 - Use of alternative procedures.

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2010-01-01

... available source, such as the Office of Government Ethics' Web site on the Internet or agency-approved... examination prior to completing an OGE Optional Form 450-A. [57 FR 11826, Apr. 7, 1992; 57 FR 21855, May 22, 1992, as amended at 62 FR 33976, June 24, 1997; 71 FR 28235, May 16, 2006] ...

40 CFR 52.2436 - Rules and regulations.

Code of Federal Regulations, 2013 CFR

2013-07-01

.... [38 FR 33725, Dec. 6, 1973, as amended at 45 FR 55197, Aug. 19, 1980; 51 FR 40677, Nov. 7, 1986; 61 FR... 40 Protection of Environment 5 2013-07-01 2013-07-01 false Rules and regulations. 52.2436 Section...) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS (CONTINUED) Virginia § 52.2436 Rules and regulations. (a...

40 CFR 52.2436 - Rules and regulations.

Code of Federal Regulations, 2012 CFR

2012-07-01

.... [38 FR 33725, Dec. 6, 1973, as amended at 45 FR 55197, Aug. 19, 1980; 51 FR 40677, Nov. 7, 1986; 61 FR... 40 Protection of Environment 5 2012-07-01 2012-07-01 false Rules and regulations. 52.2436 Section...) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS (CONTINUED) Virginia § 52.2436 Rules and regulations. (a...

40 CFR 52.2436 - Rules and regulations.

Code of Federal Regulations, 2011 CFR

2011-07-01

.... [38 FR 33725, Dec. 6, 1973, as amended at 45 FR 55197, Aug. 19, 1980; 51 FR 40677, Nov. 7, 1986; 61 FR... 40 Protection of Environment 4 2011-07-01 2011-07-01 false Rules and regulations. 52.2436 Section...) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS (CONTINUED) Virginia § 52.2436 Rules and regulations. (a...

40 CFR 52.2436 - Rules and regulations.

Code of Federal Regulations, 2010 CFR

2010-07-01

.... [38 FR 33725, Dec. 6, 1973, as amended at 45 FR 55197, Aug. 19, 1980; 51 FR 40677, Nov. 7, 1986; 61 FR... 40 Protection of Environment 4 2010-07-01 2010-07-01 false Rules and regulations. 52.2436 Section...) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS (CONTINUED) Virginia § 52.2436 Rules and regulations. (a...

29 CFR 1952.174 - Completion of developmental steps and certification.

Code of Federal Regulations, 2010 CFR

2010-07-01

... April 24, 1973, on or before June 1, 1976, with the exception that temporary labor camp standards... at 40 FR 40156, Sept. 2, 1975; 40 FR 54426, Nov. 24, 1975; 41 FR 43405, Oct. 1, 1976; 41 FR 51013..., 1976. (k) Recordkeeping and reporting requirements for private employers were promulgated by November...

31 CFR 357.26 - Direct Deposit.

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2011-07-01

... AND BILLS HELD IN TREASURY/RESERVE AUTOMATED DEBT ENTRY SYSTEM (TRADES) AND LEGACY TREASURY DIRECT... least one name that is common to both. (c) Inquiry to financial institution. Where the deposit account...) [51 FR 18265, May 16, 1986, as amended at 57 FR 38774, Aug. 27, 1992; 61 FR 6113, Feb. 16, 1996; 64 FR...

31 CFR 357.26 - Direct Deposit.

Code of Federal Regulations, 2013 CFR

2013-07-01

... AND BILLS HELD IN TREASURY/RESERVE AUTOMATED DEBT ENTRY SYSTEM (TRADES) AND LEGACY TREASURY DIRECT... least one name that is common to both. (c) Inquiry to financial institution. Where the deposit account...) [51 FR 18265, May 16, 1986, as amended at 57 FR 38774, Aug. 27, 1992; 61 FR 6113, Feb. 16, 1996; 64 FR...

31 CFR 357.26 - Direct Deposit.

Code of Federal Regulations, 2012 CFR

2012-07-01

... AND BILLS HELD IN TREASURY/RESERVE AUTOMATED DEBT ENTRY SYSTEM (TRADES) AND LEGACY TREASURY DIRECT... least one name that is common to both. (c) Inquiry to financial institution. Where the deposit account...) [51 FR 18265, May 16, 1986, as amended at 57 FR 38774, Aug. 27, 1992; 61 FR 6113, Feb. 16, 1996; 64 FR...

31 CFR 357.26 - Direct Deposit.

Code of Federal Regulations, 2014 CFR

2014-07-01

..., NOTES AND BILLS HELD IN TREASURY/RESERVE AUTOMATED DEBT ENTRY SYSTEM (TRADES) AND LEGACY TREASURY DIRECT... least one name that is common to both. (c) Inquiry to financial institution. Where the deposit account...) [51 FR 18265, May 16, 1986, as amended at 57 FR 38774, Aug. 27, 1992; 61 FR 6113, Feb. 16, 1996; 64 FR...

78 FR 6107 - Agency Information Collection Activities: Announcement of Board Approval Under Delegated...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-29

... Derivatives Market Activity (FR 3036; OMB No. 7100-0285). The FR 2436 collects similar data on the outstanding... of Foreign Exchange and Derivative Market Activity. Agency form number: FR 3036. OMB control number... and derivatives market and dealers. Estimated annual reporting hours: Turnover Survey, 2,275 hours...

78 FR 34120 - Endangered Species; Marine Mammals; Issuance of Permits

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-06

...; August 27, October 31, 2012. 2012. 704654 Scovill Zoo 77 FR 51819; August 27, October 31, 2012. 2012... Cincinnati Zoo & Botanical 77 FR 61627; October 10, November 16, 2012. Garden. 2012. 679042 Duke Lemur Center... Simon Ranch LLC 77 FR 61627; October 10, November 16, 2012. 2012. 819063 Tautphaus Park Zoo........ 77...

FR171456 is a specific inhibitor of mammalian NSDHL and yeast Erg26p

PubMed Central

Helliwell, Stephen B.; Karkare, Shantanu; Bergdoll, Marc; Rahier, Alain; Leighton-Davis, Juliet R.; Fioretto, Celine; Aust, Thomas; Filipuzzi, Ireos; Frederiksen, Mathias; Gounarides, John; Hoepfner, Dominic; Hofmann, Andreas; Imbert, Pierre-Eloi; Jeker, Rolf; Knochenmuss, Richard; Krastel, Philipp; Margerit, Anais; Memmert, Klaus; Miault, Charlotte V.; Rao Movva, N.; Muller, Alban; Naegeli, Hans-Ulrich; Oberer, Lukas; Prindle, Vivian; Riedl, Ralph; Schuierer, Sven; Sexton, Jessica A.; Tao, Jianshi; Wagner, Trixie; Yin, Hong; Zhang, Juan; Roggo, Silvio; Reinker, Stefan; Parker, Christian N.

2015-01-01

FR171456 is a natural product with cholesterol-lowering properties in animal models, but its molecular target is unknown, which hinders further drug development. Here we show that FR171456 specifically targets the sterol-4-alpha-carboxylate-3-dehydrogenase (Saccharomyces cerevisiae—Erg26p, Homo sapiens—NSDHL (NAD(P) dependent steroid dehydrogenase-like)), an essential enzyme in the ergosterol/cholesterol biosynthesis pathway. FR171456 significantly alters the levels of cholesterol pathway intermediates in human and yeast cells. Genome-wide yeast haploinsufficiency profiling experiments highlight the erg26/ERG26 strain, and multiple mutations in ERG26 confer resistance to FR171456 in growth and enzyme assays. Some of these ERG26 mutations likely alter Erg26 binding to FR171456, based on a model of Erg26. Finally, we show that FR171456 inhibits an artificial Hepatitis C viral replicon, and has broad antifungal activity, suggesting potential additional utility as an anti-infective. The discovery of the target and binding site of FR171456 within the target will aid further development of this compound. PMID:26456460

On the renormalization group perspective of α-attractors

NASA Astrophysics Data System (ADS)

Narain, Gaurav

2017-10-01

In this short paper we outline a recipe for the reconstruction of F(R) gravity starting from single field inflationary potentials in the Einstein frame. For simple potentials one can compute the explicit form of F(R), whilst for more involved examples one gets a parametric form of F(R). The F(R) reconstruction algorithm is used to study various examples: power-law phin, exponential and α-attractors. In each case it is seen that for large R (corresponding to large value of inflaton field), F(R) ~ R2. For the case of α-attractors F(R) ~ R2 for all values of inflaton field (for all values of R) as α → 0. For generic inflaton potential V(phi), it is seen that if V'/V →0 (for some phi) then the corresponding F(R) ~ R2. We then study α-attractors in more detail using non-perturbative renormalisation group methods to analyse the reconstructed F(R). It is seen that α→0 is an ultraviolet stable fixed point of the renormalisation group trajectories.

Feasibility and safety of transfemoral intra-arterial chemotherapy for head and neck cancer using a 3-French catheter system: comparison with a 4-French catheter system.

PubMed

Watanabe, Shigeru; Yamamoto, Akira; Torigoe, Teruyuki; Kanki, Akihiko; Tamada, Tsutomu; Ito, Katsuyoshi

2016-02-01

To assess the technical feasibility of transfemoral intra-arterial chemotherapy for head and neck cancer using a 3-French catheter system (3-Fr). Sixty-two patients with head and neck cancer who underwent transfemoral intra-arterial chemotherapy were included in this study. Thirty-three patients underwent treatment using a 3-Fr (group 3-Fr). Twenty-nine patients underwent treatment using a 4-French catheter system (group 4-Fr). The technical success rate, duration of the procedure with fluoroscopy, and rate of procedure-related complications were compared between group 3-Fr and group 4-Fr. In addition, in group 3-Fr, bleeding at the puncture site after 1.5 h of bed rest was evaluated. The technical success rate was 100% in both groups. The duration of the procedure with fluoroscopy didn't differ between group 3-Fr (mean 28.0 min) and group 4-Fr (mean 30.2 min) (p = 0.524). There was no procedure-related complication in either group. In group 3-Fr, no hemorrhagic complication was observed. A 3-French catheter system can be used to perform transfemoral intra-arterial chemotherapy for head and neck cancer and is technically feasible with approximately the same duration of the procedure with fluoroscopy. Furthermore, this method may shorten the bed rest time without hemorrhagic complication, and may reduce the risk of pulmonary embolism.

Effects of the tripeptide substance P antagonist, FR113680, on airway constriction and airway edema induced by neurokinins in guinea-pigs.

PubMed

Murai, M; Morimoto, H; Maeda, Y; Fujii, T

1992-06-24

FR113680 is a newly developed tripeptide substance P (SP) receptor antagonist. The effects of FR113680 on airway constriction and airway edema induced by neurokinins were investigated in guinea-pigs. In in vitro experiments, FR113680 inhibited the contraction of isolated guinea-pig trachea induced by SP and neurokinin A (NKA) in a dose-dependent manner with IC50 values of 2.3 x 10(-6) and 1.5 x 10(-5) M, respectively. The tracheal contraction induced by histamine and acetylcholine was not affected by FR113680. FR113680 (5 x 10(-5) M) also significantly inhibited the atropine-resistant contraction of isolated guinea-pig bronchi induced by electrical field stimulation. In in vivo experiments, FR113680 given i.v. inhibited SP-induced airway constriction in guinea-pigs at doses of 1 and 10 mg kg-1. However, FR113680 only inhibited NKA- and capsaicin-induced airway constriction by 40-50% even at a dose of 10 mg kg-1. FR113680 also inhibited SP-induced airway edema in guinea-pigs with the same potency as it inhibited SP-induced airway constriction. Histamine-induced airway constriction and airway edema were not affected at a dose of 10 mg kg-1. These results suggest that FR113680 preferentially inhibits responses induced by NK1 receptor activation (SP-induced airway constriction and airway edema), but is less effective on a NK2 receptor-induced response (airway constriction by NKA and neurogenic stimulation).

Changes in nucleus accumbens and neostriatal c-Fos and DARPP-32 immunoreactivity during different stages of food-reinforced instrumental training.

PubMed

Segovia, Kristen N; Correa, Merce; Lennington, Jessica B; Conover, Joanne C; Salamone, John D

2012-04-01

Nucleus accumbens is involved in several aspects of instrumental behavior, motivation and learning. Recent studies showed that dopamine (DA) release in the accumbens shell was significantly increased on the first day of training on a fixed ratio (FR) 5 schedule (i.e. the transition from FR1 to FR5) compared with those rats that continued FR1 training, even though the rats on their first day of FR5 training received less food reinforcement than rats continuing on the FR1 schedule. Additionally, the second day of FR5 responding was marked by a significant increase in DA release in accumbens core. The present studies employed immunohistochemical methods to characterize the changes in cellular markers of accumbens and neostriatal neural activity that occur during various stages of food-reinforced FR5 training. c-Fos and DARPP-32 immunoreactivity in accumbens shell was significantly increased on the first day of FR5 training, while core c-Fos and DARPP-32 expression showed large increases on the second day of FR5 training. Additional studies showed that c-Fos and DARPP-32 expression in neostriatum increased after more extensive training. Double-labeling studies with immunofluorescence methods indicated that increases in accumbens c-Fos and DARPP-32 expression were primarily seen in substance-P-positive neurons. These increases in accumbens c-Fos and DARPP-32 immunoreactivity seen during the initial phases of FR training may reflect several factors, including novelty, learning, stress or the presentation of a work-related challenge to the organism. Moreover, it appears that the separate subregions of the striatal complex are differentially activated at distinct phases of instrumental training. © 2012 The Authors. European Journal of Neuroscience © 2012 Federation of European Neuroscience Societies and Blackwell Publishing Ltd.

Physiological and Genetic Characterization of End-of-Day Far-Red Light Response in Maize Seedlings1[W][OA

PubMed Central

Dubois, Patrice G.; Olsefski, Gregory T.; Flint-Garcia, Sherry; Setter, Tim L.; Hoekenga, Owen A.; Brutnell, Thomas P.

2010-01-01

Developmental responses associated with end-of-day far-red light (EOD-FR) signaling were investigated in maize (Zea mays subspecies mays) seedlings. A survey of genetically diverse inbreds of temperate and tropical/semitropical origins, together with teosinte (Zea mays subspecies parviglumis) and a modern hybrid, revealed distinct elongation responses. A mesocotyl elongation response to the EOD-FR treatment was largely absent in the tropical/semitropical lines, but both hybrid and temperate inbred responses were of the same magnitude as in teosinte, suggesting that EOD-FR-mediated mesocotyl responses were not lost during the domestication or breeding process. The genetic architecture underlying seedling responses to EOD-FR was investigated using the intermated B73 × Mo17 mapping population. Among the different quantitative trait loci identified, two were consistently detected for elongation and responsiveness under EOD-FR, but none were associated with known light signaling loci. The central role of phytochromes in mediating EOD-FR responses was shown using a phytochromeB1 phytochromeB2 (phyB1 phyB2) mutant series. Unlike the coleoptile and first leaf sheath, EOD-FR-mediated elongation of the mesocotyl appears predominantly controlled by gibberellin. EOD-FR also reduced abscisic acid (ABA) levels in the mesocotyl for both the wild type and phyB1 phyB2 double mutants, suggesting a FR-mediated but PHYB-independent control of ABA accumulation. EOD-FR elongation responses were attenuated in both the wild type and phyB1 phyB2 double mutants when a chilling stress was applied during the dark period, concomitant with an increase in ABA levels. We present a model for the EOD-FR response that integrates light and hormonal control of seedling elongation. PMID:20668057

Externalizing behaviors in preadolescents: familial risk to externalizing behaviors and perceived parenting styles.

PubMed

Buschgens, Cathelijne J M; van Aken, Marcel A G; Swinkels, Sophie H N; Ormel, Johan; Verhulst, Frank C; Buitelaar, Jan K

2010-07-01

The aim was to investigate the contribution of familial risk to externalizing behaviors (FR-EXT), perceived parenting styles, and their interactions to the prediction of externalizing behaviors in preadolescents. Participants were preadolescents aged 10-12 years who participated in TRAILS, a large prospective population-based cohort study in the Netherlands (N = 2,230). Regression analyses were used to determine the relative contribution of FR-EXT and perceived parenting styles to parent and teacher ratings of externalizing behaviors. FR-EXT was based on lifetime parental externalizing psychopathology and the different parenting styles (emotional warmth, rejection, and overprotection) were based on the child's perspective. We also investigated whether different dimensions of perceived parenting styles had different effects on subdomains of externalizing behavior. We found main effects for FR-EXT (vs. no FR-EXT), emotional warmth, rejection, and overprotection that were fairly consistent across rater and outcome measures. More specific, emotional warmth was the most consistent predictor of all outcome measures, and rejection was a stronger predictor of aggression and delinquency than of inattention. Interaction effects were found for FR-EXT and perceived parental rejection and overprotection; other interactions between FR-EXT and parenting styles were not significant. Correlations between FR-EXT and perceived parenting styles were absent or very low and were without clinical significance. Predominantly main effects of FR-EXT and perceived parenting styles independently contribute to externalizing behaviors in preadolescents, suggesting FR-EXT and parenting styles to be two separate areas of causality. The relative lack of gene-environment interactions may be due to the epidemiological nature of the study, the preadolescent age of the subjects, the measurement level of parenting and the measurement level of FR-EXT, which might be a consequence of both genetic and environmental factors.

Mitigation of Faraday rotation in ALOS-2/PALSAR-2 full polarimetric SAR imageries

NASA Astrophysics Data System (ADS)

Mohanty, Shradha; Singh, Gulab

2016-05-01

The ionosphere, which extends from 50-450 kms in earth's atmosphere, is a particularly important region with regards electromagnetic wave propagation and radio communications in the L-band and lower frequencies. These ions interact with the traversing electromagnetic wave and cause rotation of polarization of the radar signal. In this paper, a potentially computable method for quantifying Faraday rotation (FR), is discussed with the knowledge of full polarimetric ALOS/PALSAR data and ALOS-2/PALSAR-2 data. For a well calibrated monostatic, full-pol ALOS-2/PALSAR-2 data, the reciprocal symmetry of the received scattering matrix is violated due to FR. Apart from FR, other system parameters like residual system noise, channel amplitude, phase imbalance and cross-talk, also account for the non-symmetry. To correct for the FR effect, firstly the noise correction was performed. PALSAR/PALSAR-2 data was converted into 4×4 covariance matrix to calculate the coherence between cross-polarized elements. Covariance matrix was modified by the coherence factor. For FR corrections, the covariance matrix was converted into 4×4 coherency matrix. The elements of coherency matrix were used to estimate FR angle and correct for FR. Higher mean FR values during ALOS-PALSAR measurements can be seen in regions nearer to the equator and the values gradually decrease with increase in latitude. Moreover, temporal variations in FR can also be noticed over different years (2006-2010), with varying sunspot activities for the Niigata, Japan test site. With increasing sunspot activities expected during ALOS-2/PALSAR-2 observations, more striping effects were observed over Mumbai, India. This data has also been FR corrected, with mean FR values of about 8°, using the above mentioned technique.

Morphology, spatial distribution, and concentration of flame retardants in consumer products and environmental dusts using scanning electron microscopy and Raman micro-spectroscopy.

PubMed

Wagner, Jeff; Ghosal, Sutapa; Whitehead, Todd; Metayer, Catherine

2013-09-01

We characterized flame retardant (FR) morphologies and spatial distributions in 7 consumer products and 7 environmental dusts to determine their implications for transfer mechanisms, human exposure, and the reproducibility of gas chromatography-mass spectrometry (GC-MS) dust measurements. We characterized individual particles using scanning electron microscopy/energy dispersive x-ray spectroscopy (SEM/EDS) and Raman micro-spectroscopy (RMS). Samples were screened for the presence of 3 FR constituents (bromine, phosphorous, non-salt chlorine) and 2 metal synergists (antimony and bismuth). Subsequent analyses of select samples by RMS enabled molecular identification of the FR compounds and matrix materials. The consumer products and dust samples possessed FR elemental weight percents of up to 36% and 31%, respectively. We identified 24 FR-containing particles in the dust samples and classified them into 9 types based on morphology and composition. We observed a broad range of morphologies for these FR-containing particles, suggesting FR transfer to dust via multiple mechanisms. We developed an equation to describe the heterogeneity of FR-containing particles in environmental dust samples. The number of individual FR-containing particles expected in a 1-mg dust sample with a FR concentration of 100ppm ranged from <1 to >1000 particles. The presence of rare, high-concentration bromine particles was correlated with decabromodiphenyl ether concentrations obtained via GC-MS. When FRs are distributed heterogeneously in highly concentrated dust particles, human exposure to FRs may be characterized by high transient exposures interspersed by periods of low exposure, and GC-MS FR concentrations may exhibit large variability in replicate subsamples. Current limitations of this SEM/EDS technique include potential false negatives for volatile and chlorinated FRs and greater quantitation uncertainty for brominated FR in aluminum-rich matrices. Copyright © 2013 Elsevier Ltd. All rights reserved.

Copy number and haplotype variation at the VRN-A1 and central FR-A2 loci are associated with frost tolerance in hexaploid wheat.

PubMed

Zhu, Jie; Pearce, Stephen; Burke, Adrienne; See, Deven Robert; Skinner, Daniel Z; Dubcovsky, Jorge; Garland-Campbell, Kimberly

2014-05-01

The interaction between VRN - A1 and FR - A2 largely affect the frost tolerance of hexaploid wheat. Frost tolerance is critical for wheat survival during cold winters. Natural variation for this trait is mainly associated with allelic differences at the VERNALIZATION 1 (VRN1) and FROST RESISTANCE 2 (FR2) loci. VRN1 regulates the transition between vegetative and reproductive stages and FR2, a locus including several tandemly duplicated C-REPEAT BINDING FACTOR (CBF) transcription factors, regulates the expression of Cold-regulated genes. We identified sequence and copy number variation at these two loci among winter and spring wheat varieties and characterized their association with frost tolerance. We identified two FR-A2 haplotypes-'FR-A2-S' and 'FR-A2-T'-distinguished by two insertion/deletions and ten single nucleotide polymorphisms within the CBF-A12 and CBF-A15 genes. Increased copy number of CBF-A14 was frequently associated with the FR-A2-T haplotype and with higher CBF14 transcript levels in response to cold. Factorial ANOVAs revealed significant interactions between VRN1 and FR-A2 for frost tolerance in both winter and spring panels suggesting a crosstalk between vernalization and cold acclimation pathways. The model including these two loci and their interaction explained 32.0 and 20.7 % of the variation in frost tolerance in the winter and spring panels, respectively. The interaction was validated in a winter wheat F 4:5 population segregating for both genes. Increased VRN-A1 copy number was associated with improved frost tolerance among varieties carrying the FR-A2-T allele but not among those carrying the FR-A2-S allele. These results suggest that selection of varieties carrying the FR-A2-T allele and three copies of the recessive vrn-A1 allele would be a good strategy to improve frost tolerance in wheat.

Initial experience with the 3.3 Fr Mongoose® pigtail catheter for aortic angiography during patent ductus arteriosus closure in small patients

PubMed Central

Hena, Zachary; Sutton, Nicole J; Gates, Gregory J; Taragin, Benjamin H; Pass, Robert H

2017-01-01

Background: Smaller femoral arterial sheaths may be associated with fewer vascular complications. The 3.3 Fr Mongoose® Pediavascular pigtail catheter is a catheter that allows higher flow rates, potentially resulting in improved angiographic quality. We reviewed our experience with this small catheter during patent ductus arteriosus (PDA) closure. Materials and Methods: Review of patients ≤20 kg in whom the Mongoose® catheter was used during PDA closure from 12/13 to 4/15. Angiographic efficacy and procedural details were compared to ten 4 Fr catheter cases. Comparisons were performed using Mann–Whitney U-test; P < 0.05 was statistically significant. Results: Twelve (9 female) patients were catheterized with a 3.3 Fr Mongoose®. Median weight 10.5 kg (range 6.4–18.2), height 81 cm (range 37–111), and body surface area (BSA) 0.47 m2 (range 0.33–0.75) were similar to ten patients (3 females) in the 4 Fr control group (P = NS); median weight 9.9 kg (range 6–16.8), height 80 cm (range 64–102), and BSA 0.46 m2 (range 0.31–0.74). Angiographic quality was subjectively adequate with both with no difference in the median pixel density between the two techniques (3.3 Fr: 76.7 [range 33.5–90] and 4 Fr: [70; 38–102]; P = NS). Contrast used was similar between the groups (3.3 Fr: median 4.2 ml/kg and 4 Fr: 4.9 ml/kg; P = NS). Median radiation dose was similar in the two groups (3.3 Fr: 28.1 mGy [range 17.2–38] and 4 Fr: 38 mGy [range 20.4–58.5]; P = NS). All ducts were closed at latest follow-up (P = NS). No complications were encountered. Conclusions: The 3.3 Fr Mongoose® allowed similar angiography to the 4 Fr pigtail catheter, allowing safe and effective transcatheter PDA closure in small children. PMID:28928609

Ethanol production from a biomass mixture of furfural residues with green liquor-peroxide saccarified cassava liquid.

PubMed

Ji, Li; Zheng, Tianran; Zhao, Pengxiang; Zhang, Weiming; Jiang, Jianxin

2016-06-01

As the most abundant renewable resources, lignocellulosic materials are ideal candidates as alternative feedstock for bioethanol production. Cassava residues (CR) are byproducts of the cassava starch industry which can be mixed with lignocellulosic materials for ethanol production. The presence of lignin in lignocellulosic substrates can inhibit saccharification by reducing the cellulase activity. Simultaneous saccharification and fermentation (SSF) of furfural residues (FR) pretreated with green liquor and hydrogen peroxide (GL-H2O2) with CR saccharification liquid was investigated. The final ethanol concentration, yield, initial rate, number of live yeast cells, and the dead yeast ratio were compared to evaluate the effectiveness of combining delignificated lignocellulosic substrates and starchy substrates for ethanol production. Our results indicate that 42.0 % of FR lignin removal was achieved on FR using of 0.06 g H2O2/g-substrate and 9 mL GL/g-substrate at 80 °C. The highest overall ethanol yield was 93.6 % of the theoretical. When the ratio of 0.06 g/g-H2O2-GL-pretreated FR to CR was 5:1, the ethanol concentration was the same with that ratio of untreated FR to CR of 1:1. Using 0.06 g/g-H2O2-GL-pretreated FR with CR at a ratio of 2:1 resulted in 51.9 g/L ethanol concentration. Moreover, FR pretreated with GL-H2O2 decreased the concentration of byproducts in SSF compared with that obtained in the previous study. The lignin in FR would inhibit enzyme activity and GL-H2O2 is an advantageous pretreatment method to treat FR and high intensity of FR pretreatment increased the final ethanol concentration. The efficiency of ethanol fermentation of was improved when delignification increased. GL-H2O2 is an advantageous pretreatment method to treat FR. As the pretreatment dosage of GL-H2O2 on FR increased, the proportion of lignocellulosic substrates was enhanced in the SSF of the substrate mixture of CR and FR as compared with untreated FR. Moreover, the final ethanol concentration was increased with a high ethanol yield and lower byproduct concentrations.

Mapping cell populations in flow cytometry data for cross-sample comparison using the Friedman-Rafsky test statistic as a distance measure.

PubMed

Hsiao, Chiaowen; Liu, Mengya; Stanton, Rick; McGee, Monnie; Qian, Yu; Scheuermann, Richard H

2016-01-01

Flow cytometry (FCM) is a fluorescence-based single-cell experimental technology that is routinely applied in biomedical research for identifying cellular biomarkers of normal physiological responses and abnormal disease states. While many computational methods have been developed that focus on identifying cell populations in individual FCM samples, very few have addressed how the identified cell populations can be matched across samples for comparative analysis. This article presents FlowMap-FR, a novel method for cell population mapping across FCM samples. FlowMap-FR is based on the Friedman-Rafsky nonparametric test statistic (FR statistic), which quantifies the equivalence of multivariate distributions. As applied to FCM data by FlowMap-FR, the FR statistic objectively quantifies the similarity between cell populations based on the shapes, sizes, and positions of fluorescence data distributions in the multidimensional feature space. To test and evaluate the performance of FlowMap-FR, we simulated the kinds of biological and technical sample variations that are commonly observed in FCM data. The results show that FlowMap-FR is able to effectively identify equivalent cell populations between samples under scenarios of proportion differences and modest position shifts. As a statistical test, FlowMap-FR can be used to determine whether the expression of a cellular marker is statistically different between two cell populations, suggesting candidates for new cellular phenotypes by providing an objective statistical measure. In addition, FlowMap-FR can indicate situations in which inappropriate splitting or merging of cell populations has occurred during gating procedures. We compared the FR statistic with the symmetric version of Kullback-Leibler divergence measure used in a previous population matching method with both simulated and real data. The FR statistic outperforms the symmetric version of KL-distance in distinguishing equivalent from nonequivalent cell populations. FlowMap-FR was also employed as a distance metric to match cell populations delineated by manual gating across 30 FCM samples from a benchmark FlowCAP data set. An F-measure of 0.88 was obtained, indicating high precision and recall of the FR-based population matching results. FlowMap-FR has been implemented as a standalone R/Bioconductor package so that it can be easily incorporated into current FCM data analytical workflows. © The Authors. Published by Wiley Periodicals, Inc. on behalf of ISAC.

78 FR 56633 - Approval and Promulgation of Air Quality Implementation Plans; New York; Determination of Clean...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-13

... standard in Coso Junction, California), and 75 FR 6571 (February 10, 2010) (the determination of attainment..., 2007) (Miami, Arizona area); 75 FR 27944 (May 19, 2010) (Coso Junction, California area); and 76 FR... Coso Junction areas in California, make clear that the same reasoning applies to the PM 10 provisions...

48 CFR 252.247-7011 - Period of contract.

Code of Federal Regulations, 2011 CFR

2011-10-01

...) for 180 days past the expiration date. (End of clause) [56 FR 36479, July 31, 1991, as amended at 66 FR 49861, Oct. 1, 2001] [56 FR 36479, July 31, 1991, as amended at 75 FR 51418, Aug. 20, 2010] ... clause: Period of Contract (OCT 2001) (a) This contract begins January 1, __, and ends December 31...

48 CFR 252.247-7011 - Period of contract.

Code of Federal Regulations, 2010 CFR

2010-10-01

...) for 180 days past the expiration date. (End of clause) [56 FR 36479, July 31, 1991, as amended at 66 FR 49861, Oct. 1, 2001] [56 FR 36479, July 31, 1991, as amended at 75 FR 51418, Aug. 20, 2010] ... clause: Period of Contract (OCT 2001) (a) This contract begins January 1, __, and ends December 31...

27 CFR 71.117 - Permit privileges, exceptions.

Code of Federal Regulations, 2011 CFR

2011-04-01

... force and effect except that, in the case of industrial use permits, any time after a citation has been... withdrawal permit. [T.D. 6389, 24 FR 4791, June 12, 1959. Redesignated at 40 FR 16835, Apr. 15, 1975; T.D. ATF-199, 50 FR 9197, Mar. 6, 1985; T.D. ATF-374, 61 FR 29957, June 13, 1996] ...

19 CFR 112.26 - Duration of license.

Code of Federal Regulations, 2011 CFR

2011-04-01

... license issued in accordance with this subpart shall remain in force and effect until the license is... this chapter. [T.D. 76-324, 41 FR 50822, Nov. 18, 1976, as amended by T.D. 84-213, 49 FR 41171, Oct. 19, 1984; 49 FR 44867, Nov. 9, 1984; T.D. 97-82, 62 FR 51770, Oct. 3, 1997] ...

19 CFR 112.26 - Duration of license.

Code of Federal Regulations, 2010 CFR

2010-04-01

... license issued in accordance with this subpart shall remain in force and effect until the license is... this chapter. [T.D. 76-324, 41 FR 50822, Nov. 18, 1976, as amended by T.D. 84-213, 49 FR 41171, Oct. 19, 1984; 49 FR 44867, Nov. 9, 1984; T.D. 97-82, 62 FR 51770, Oct. 3, 1997] ...

27 CFR 71.117 - Permit privileges, exceptions.

Code of Federal Regulations, 2010 CFR

2010-04-01

... force and effect except that, in the case of industrial use permits, any time after a citation has been... withdrawal permit. [T.D. 6389, 24 FR 4791, June 12, 1959. Redesignated at 40 FR 16835, Apr. 15, 1975; T.D. ATF-199, 50 FR 9197, Mar. 6, 1985; T.D. ATF-374, 61 FR 29957, June 13, 1996] ...

78 FR 60379 - Board of Veterans Appeals, Voice of the Veteran Appellant Surveys; Correction

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-01

... collection notice in a Federal Register on September 6, 2013 (78 FR 54956), that contained errors. VA... 20420, at (202) 632-7492 or [email protected] . Correction In FR Doc. 2013-21699, published on September 6, 2013, at 78 FR 54956, make the following corrections. On page 54956, in the third column, at...

75 FR 10438 - Effluent Limitations Guidelines and Standards for the Construction and Development Point Source...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-08

... CONTACT: Mr. Jesse W. Pritts at 202-566-1038 ( [email protected] ). SUPPLEMENTARY INFORMATION... Executive Order 13084. 63 FR 27655 (May 10, 1998). This rule will not have substantial direct effects on the.... 64 FR 43255 (August 10, 1999). This rule also is not subject to Executive Order 13045, 62 FR 19885...

77 FR 73523 - HUD Acquisition Regulations (HUDAR)

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-10

... authorization in FAR 1.301. HUDAR was last revised by final rule published on January 13, 2006 (71 FR 2432). II. Public Comments The proposed rule was published on March 16, 2012 (77 FR 15681), and the public comment... corrections) the proposed amendments to the HUDAR, made by proposed rule published on March 16, 2012 (77 FR...

42 CFR 412.84 - Payment for extraordinarily high-cost cases (cost outliers).

Code of Federal Regulations, 2014 CFR

2014-10-01

... request additional payment— (1) With initial submission of the bill; or (2) Within 60 days of receipt of the intermediary's initial determination. (c) Except as specified in paragraph (e) of this section, an.... 3, 1985; 51 FR 31496, Sept. 3, 1986; 53 FR 38529, Sept. 30, 1988; 54 FR 36494, Sept. 1, 1989; 55 FR...

78 FR 2397 - Agency Information Collection Activities: Announcement of Board Approval Under Delegated...

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2013-01-11

...--Division of Research and Statistics, Board of Governors of the Federal Reserve System, Washington, DC 20551... Report of Specific Issues (FR 2004SI), Daily Report of Specific Issues (FR 2004SD), Supplement to the Daily Report of Specific Issues (FR 2004SD ad hoc), and Daily Report of Dealer Activity in Treasury...

76 FR 56708 - Ohio: Final Authorization of State Hazardous Waste Management Program Revision

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2011-09-14

.... January 4, 1989, 54 FR 246.... NESHAPS: Final Standards for May 14, 2001, 66 FR 24270..... OAC 3745-50-41...; Checklist 188.1. NESHAPS: Interim Standards for February 13, 2002, 67 FR 6792. OAC 3745-50-44; 3745-50-66... Waste Combustors 2009. (Interim Standards Rule); Checklist 197. NESHAPS: Standards for Hazardous...

50 CFR 223.102 - Enumeration of threatened marine and anadromous species.

Code of Federal Regulations, 2010 CFR

2010-10-01

..., Panama, Venezuela and all the islands of the West Indies. 71 FR 26852, May 9, 2006 73 FR 72210, Nov. 26..., Honduras, Mexico, Nicaragua, Panama, Venezuela and all the islands of the West Indies. 71 FR 26852, May 9... segments (DPSs) (for a policy statement, see 61 FR 4722, February 7, 1996), and evolutionarily significant...

Exploring plane-symmetric solutions in f(R) gravity

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shamir, M. F., E-mail: farasat.shamir@nu.edu.pk

2016-02-15

The modified theories of gravity, especially the f(R) gravity, have attracted much attention in the last decade. This paper is devoted to exploring plane-symmetric solutions in the context of metric f(R) gravity. We extend the work on static plane-symmetric vacuum solutions in f(R) gravity already available in the literature [1, 2]. The modified field equations are solved using the assumptions of both constant and nonconstant scalar curvature. Some well-known solutions are recovered with power-law and logarithmic forms of f(R) models.

Use of Modal Acoustic Emission to Monitor Damage Progression in Carbon Fiber/Epoxy Tows and Implications for Composite Structures

NASA Technical Reports Server (NTRS)

Waller, Jess M.; Saulsberry, Regor L.; Lucero, Ralph; Nichols, Charles T.; Wentzel, Daniel J.

2010-01-01

ASTM-based ILH methods were found to give a reproducible, quantitative estimate of the stress threshold at which significant accumulated damage began to occur. a) FR events are low energy (<2 V(exp 20 microsec) b) FR events occur close to the observed failure locus. c) FR events consist of more than 30% fiber breakage (>300 kHz) d) FR events show a consistent hierarchy of cooperative damage for composite tow, and for the COPV tested, regardless of applied load. Application of ILH or related stress profiles could lead to robust pass/fail acceptance criteria based on the FR. Initial application of FR and FFT analysis of AE data acquired on COPVs is promising.

visCOS: An R-package to evaluate model performance of hydrological models

NASA Astrophysics Data System (ADS)

Klotz, Daniel; Herrnegger, Mathew; Wesemann, Johannes; Schulz, Karsten

2016-04-01

The evaluation of model performance is a central part of (hydrological) modelling. Much attention has been given to the development of evaluation criteria and diagnostic frameworks. (Klemeš, 1986; Gupta et al., 2008; among many others). Nevertheless, many applications exist for which objective functions do not yet provide satisfying summaries. Thus, the necessity to visualize results arises in order to explore a wider range of model capacities, be it strengths or deficiencies. Visualizations are usually devised for specific projects and these efforts are often not distributed to a broader community (e.g. via open source software packages). Hence, the opportunity to explicitly discuss a state-of-the-art presentation technique is often missed. We therefore present a comprehensive R-package for evaluating model performance by visualizing and exploring different aspects of hydrological time-series. The presented package comprises a set of useful plots and visualization methods, which complement existing packages, such as hydroGOF (Zambrano-Bigiarini et al., 2012). It is derived from practical applications of the hydrological models COSERO and COSEROreg (Kling et al., 2014). visCOS, providing an interface in R, represents an easy-to-use software package for visualizing and assessing model performance and can be implemented in the process of model calibration or model development. The package provides functions to load hydrological data into R, clean the data, process, visualize, explore and finally save the results in a consistent way. Together with an interactive zoom function of the time series, an online calculation of the objective functions for variable time-windows is included. Common hydrological objective functions, such as the Nash-Sutcliffe Efficiency and the Kling-Gupta Efficiency, can also be evaluated and visualized in different ways for defined sub-periods like hydrological years or seasonal sections. Many hydrologists use long-term water-balances as a pivotal tool in model evaluation. They allow inferences about different systematic model-shortcomings and are an efficient way for communicating these in practice (Schulz et al., 2015). The evaluation and construction of such water balances is implemented with the presented package. During the (manual) calibration of a model or in the scope of model development, many model runs and iterations are necessary. Thus, users are often interested in comparing different model results in a visual way in order to learn about the model and to analyse parameter-changes on the output. A method to illuminate these differences and the evolution of changes is also included. References: • Gupta, H.V.; Wagener, T.; Liu, Y. (2008): Reconciling theory with observations: elements of a diagnostic approach to model evaluation, Hydrol. Process. 22, doi: 10.1002/hyp.6989. • Klemeš, V. (1986): Operational testing of hydrological simulation models, Hydrolog. Sci. J., doi: 10.1080/02626668609491024. • Kling, H.; Stanzel, P.; Fuchs, M.; and Nachtnebel, H. P. (2014): Performance of the COSERO precipitation-runoff model under non-stationary conditions in basins with different climates, Hydrolog. Sci. J., doi: 10.1080/02626667.2014.959956. • Schulz, K., Herrnegger, M., Wesemann, J., Klotz, D. Senoner, T. (2015): Kalibrierung COSERO - Mur für Pro Vis, Verbund Trading GmbH (Abteilung STG), final report, Institute of Water Management, Hydrology and Hydraulic Engineering, University of Natural Resources and Applied Life Sciences, Vienna, Austria, 217pp. • Zambrano-Bigiarini, M; Bellin, A. (2010): Comparing Goodness-of-fit Measures for Calibration of Models Focused on Extreme Events. European Geosciences Union (EGU), Geophysical Research Abstracts 14, EGU2012-11549-1.

78 FR 55225 - Determination of Attainment for the Chico Nonattainment Area for the 2006 Fine Particle Standard...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-10

...); and 75 FR 27944 (May 19, 2010) (Coso Junction, California area). Thus EPA has established that, under... Office of Management and Budget under Executive Order 12866 (58 FR 51735, October 4, 1993); Does not... based on health or safety risks subject to Executive Order 13045 (62 FR 19885, April 23, 1997); Is not a...

Parental Literacy Predicts Children's Literacy: A Longitudinal Family-Risk Study

ERIC Educational Resources Information Center

Torppa, Minna; Eklund, Kenneth; van Bergen, Elsje; Lyytinen, Heikki

2011-01-01

This family-risk (FR) study examined whether the literacy skills of parents with dyslexia are predictive of the literacy skills of their offspring. We report data from 31 child-parent dyads where both had dyslexia (FR-D) and 68 dyads where the child did not have dyslexia (FR-ND). Findings supported the differences in liability of FR children with…

40 CFR 52.2020 - Identification of plan.

Code of Federal Regulations, 2012 CFR

2012-07-01

...) Compliance and test methods 11/1/97 6/8/98, 63 FR 31116 (c)(131). Subchapter D—Motor Vehicle Emissions.../02 12/8/04, 69 FR 70893 (c)(229). Section 130.108 Test procedures 10/5/02 12/8/04, 69 FR 70893 (c....414 Modification of variance 10/11/08 10/18/10, 75 FR 63717. TEST METHODS Section 130.431 Testing for...

19 CFR 207.7 - Limited disclosure of certain business proprietary information under administrative protective...

Code of Federal Regulations, 2014 CFR

2014-04-01

... 19 Customs Duties 3 2014-04-01 2014-04-01 false Limited disclosure of certain business proprietary... order, and file with the Secretary a certificate attesting to his personal, good faith belief that all..., 1994; 61 FR 37829, July 22, 1996; 68 FR 32978, June 3, 2003; 70 FR 8512, Feb. 22, 2005; 76 FR 61942...

19 CFR 207.7 - Limited disclosure of certain business proprietary information under administrative protective...

Code of Federal Regulations, 2012 CFR

2012-04-01

... 19 Customs Duties 3 2012-04-01 2012-04-01 false Limited disclosure of certain business proprietary... order, and file with the Secretary a certificate attesting to his personal, good faith belief that all..., 1994; 61 FR 37829, July 22, 1996; 68 FR 32978, June 3, 2003; 70 FR 8512, Feb. 22, 2005; 76 FR 61942...

19 CFR 207.7 - Limited disclosure of certain business proprietary information under administrative protective...

Code of Federal Regulations, 2013 CFR

2013-04-01

... 19 Customs Duties 3 2013-04-01 2013-04-01 false Limited disclosure of certain business proprietary... order, and file with the Secretary a certificate attesting to his personal, good faith belief that all..., 1994; 61 FR 37829, July 22, 1996; 68 FR 32978, June 3, 2003; 70 FR 8512, Feb. 22, 2005; 76 FR 61942...

40 CFR 52.2420 - Identification of plan.

Code of Federal Regulations, 2011 CFR

2011-07-01

.../19/11, 76 FR 3023 Removal of “Reasonably available control technology” from 5-40-250C. 5-40-260... Volatile Organic Compounds 4/17/95 4/21/00, 65 FR 21315 120-04-0503. 5-40-460 Control Technology Guidelines... 4/21/00, 65 FR 21315 120-04-0603. 5-40-610 Control Technology Guidelines 4/17/95 4/21/00, 65 FR...

40 CFR 52.1220 - Identification of plan.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 49303 7017.1135 Applicability 03/01/99 08/10/11, 76 FR 49303 7017.1140 CEMS design requirements 03/01/99... 7017.1190 COMS design requirements 03/01/99 08/10/11, 76 FR 49303 7017.1200 COMS monitoring data 03/01.../01/99 08/10/11, 76 FR 49303 7017.2030 Performance test pretest requirements 03/01/99 08/10/11, 76 FR...

40 CFR 52.1220 - Identification of plan.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 49303 7017.1135 Applicability 03/01/99 08/10/11, 76 FR 49303 7017.1140 CEMS design requirements 03/01/99... 7017.1190 COMS design requirements 03/01/99 08/10/11, 76 FR 49303 7017.1200 COMS monitoring data 03/01.../01/99 08/10/11, 76 FR 49303 7017.2030 Performance test pretest requirements 03/01/99 08/10/11, 76 FR...

40 CFR 52.1220 - Identification of plan.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 49303 7017.1135 Applicability 03/01/99 08/10/11, 76 FR 49303 7017.1140 CEMS design requirements 03/01/99... 7017.1190 COMS design requirements 03/01/99 08/10/11, 76 FR 49303 7017.1200 COMS monitoring data 03/01.../01/99 08/10/11, 76 FR 49303 7017.2030 Performance test pretest requirements 03/01/99 08/10/11, 76 FR...

75 FR 16179 - Notice of Affirmative Decisions on Petitions for Modification Granted in Whole or in Part

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-31

...-013-C FR Notice: 74 FR 27185 (June 8, 2009). Petitioner: Wolf Run Mining Company, Rt. 3, Box 146... FR 23745 (May 20, 2009). Petitioner: Excel Mining, LLC, Box 4126, State Highway 194 West, Pikeville... Heights, P.O. Box 1944, Superior, Arizona 85273. Mine: Resolution Copper Mine, MSHA I.D. No. 02-00152...

75 FR 4795 - Energy Conservation Program for Certain Industrial Equipment: Publication of the Petition for...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-29

... 10, 2008) (Daikin waiver); 74 FR 15955 (April 8, 2009) (Daikin waiver); 74 FR 16193 (April 9, 2009) (Sanyo waiver); 74 FR 16373 (April 10, 2009) (Daikin waiver) The VRV-WIII systems have operational... water-source multi-split products on the basis of the existing test procedure under 10 CFR 431.96, which...

40 CFR 52.620 - Identification of plan.

Code of Federal Regulations, 2011 CFR

2011-07-01

.../29/1982 08/18/1983, 48 FR 37403 11-60-18 Control of open burning 11/29/1982 08/18/1983, 48 FR 37403 11-60-19 Agricultural burning, permit requirement 11/29/1982 08/18/1983, 48 FR 37403 11-60-20 Agricultural burning, applications 11/29/1982 08/18/1983, 48 FR 37403 11-60-21 Agricultural burning, “no burn...

Watermelon germplasm lines USVL246-FR2 and USVL252-FR2 tolerant to fusarium oxysporum f. sp. niveum race 2

USDA-ARS?s Scientific Manuscript database

Two improved germplasm lines of wild watermelon (Citrullus lanatus var. citroides) designated USVL246-FR2 and USVL252-FR2 were released in 2012 by the Agricultural Research Service of the U.S. Department of Agriculture (Wechter et al. 2012). These lines are each highly uniform for growth characteri...

9 CFR 381.175 - Records required to be kept.

Code of Federal Regulations, 2011 CFR

2011-01-01

... slaughter. (b) The required records are: (1) Records, such as bills of sale, invoices, bills of lading, and... § 381.144. (3) Records of canning as required by subpart X of this part 381, of subchapter C, 9 CFR... 47 FR 746, Jan. 7, 1982; 49 FR 2236, Jan. 19, 1984; 51 FR 45633, Dec. 19, 1986; 57 FR 43600, Sept. 21...

9 CFR 381.175 - Records required to be kept.

Code of Federal Regulations, 2014 CFR

2014-01-01

... are: (1) Records, such as bills of sale, invoices, bills of lading, and receiving and shipping papers... by subpart X of this part 381, of subchapter C, 9 CFR chapter III. (4) Records of irradiation as..., Jan. 19, 1984; 51 FR 45633, Dec. 19, 1986; 57 FR 43600, Sept. 21, 1992; 58 FR 675, Jan. 6, 1993; 60 FR...

18 CFR 2.1 - Initial notice; service; and information copies of formal documents.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Initial notice; service; and information copies of formal documents. 2.1 Section 2.1 Conservation of Power and Water Resources... Order 463, 37 FR 28054, Dec. 20, 1972; 38 FR 3192, Feb. 2, 1973; 44 FR 34941, June 18, 1979; 45 FR 21224...

18 CFR 2.1 - Initial notice; service; and information copies of formal documents.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 18 Conservation of Power and Water Resources 1 2013-04-01 2013-04-01 false Initial notice; service; and information copies of formal documents. 2.1 Section 2.1 Conservation of Power and Water Resources...; 38 FR 3192, Feb. 2, 1973; 44 FR 34941, June 18, 1979; 45 FR 21224, Apr. 1, 1980; Order 541, 57 FR...

18 CFR 2.1 - Initial notice; service; and information copies of formal documents.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 18 Conservation of Power and Water Resources 1 2014-04-01 2014-04-01 false Initial notice; service; and information copies of formal documents. 2.1 Section 2.1 Conservation of Power and Water Resources...; 38 FR 3192, Feb. 2, 1973; 44 FR 34941, June 18, 1979; 45 FR 21224, Apr. 1, 1980; Order 541, 57 FR...

18 CFR 2.1 - Initial notice; service; and information copies of formal documents.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 18 Conservation of Power and Water Resources 1 2012-04-01 2012-04-01 false Initial notice; service; and information copies of formal documents. 2.1 Section 2.1 Conservation of Power and Water Resources...; 38 FR 3192, Feb. 2, 1973; 44 FR 34941, June 18, 1979; 45 FR 21224, Apr. 1, 1980; Order 541, 57 FR...

40 CFR 52.1220 - Identification of plan.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Performance tests 10/18/93 05/24/95, 60 FR 27411 7011.0150 Preventing particulate matter from becoming....0525 High heating value 10/18/93 05/24/95, 60 FR 27411 7011.0530 Performance test methods 10/18/93 05/24/95, 60 FR 27411 7011.0535 Performance test procedures 10/18/93 05/24/95, 60 FR 27411 7011.0540...

40 CFR 52.1220 - Identification of plan.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Performance tests 10/18/93 05/24/95, 60 FR 27411 7011.0150 Preventing particulate matter from becoming....0525 High heating value 10/18/93 05/24/95, 60 FR 27411 7011.0530 Performance test methods 10/18/93 05/24/95, 60 FR 27411 7011.0535 Performance test procedures 10/18/93 05/24/95, 60 FR 27411 7011.0540...

78 FR 11815 - Creation of a New Computer Matching Program That Will Expire on August 13, 2014

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-20

... Applications, SSA/OEEAS, 60-0058, full text published at 71 FR 1815 (January 11, 2006); the Master Beneficiary Record, SSA/ ORSIS 60-0090, full text published at 71 FR 1826 (January 11, 2006); and Supplemental Security Income and Special Veterans Benefits SSA/ ODSSIS, 60-0103, full text published at 71 FR 1826...

Interaction of reinforcement schedules, a behavioral prosthesis, and work-related behavior in adults with mental retardation.

PubMed

Saunders, Richard R; McEntee, Julie E; Saunders, Muriel D

2005-01-01

The effects of variable-interval (VI) and fixed-ratio (FR) schedules of reinforcement for work-related behavior and an organizer for the work materials (behavioral prosthesis) were evaluated with 3 adults with severe or profound mental retardation. The participants had been recommended for study because of high rates of off-task and aberrant behavior in their daily vocational training programs. For 2 participants, VI and FR schedules resulted in the same outcome: more aberrant behavior than on-task and off-task behavior combined. The FR schedule nearly eliminated emission of aberrant and off-task behavior by the 3rd participant. Combining the behavioral prosthesis with FR reinforcement (FR+O) increased the proportion of time spent in on-task behavior by all participants under certain FR schedule parameters. Second-by-second analyses of the observation records revealed that FR schedules reduced off-task and aberrant behavior during work sequences (i.e., ratio runs), and FR+O led to a further reduction of these behaviors during postreinforcement pauses. Overall, the results show how organizer and schedule parameters can be adjusted to produce an optimized balance between productivity and reinforcement while undesirable behavior is minimized.

Intricacies of cosmological bounce in polynomial metric f(R) gravity for flat FLRW spacetime

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bhattacharya, Kaushik; Chakrabarty, Saikat, E-mail: kaushikb@iitk.ac.in, E-mail: snilch@iitk.ac.in

2016-02-01

In this paper we present the techniques for computing cosmological bounces in polynomial f(R) theories, whose order is more than two, for spatially flat FLRW spacetime. In these cases the conformally connected Einstein frame shows up multiple scalar potentials predicting various possibilities of cosmological evolution in the Jordan frame where the f(R) theory lives. We present a reasonable way in which one can associate the various possible potentials in the Einstein frame, for cubic f(R) gravity, to the cosmological development in the Jordan frame. The issue concerning the energy conditions in f(R) theories is presented. We also point out themore » very important relationships between the conformal transformations connecting the Jordan frame and the Einstein frame and the various instabilities of f(R) theory. All the calculations are done for cubic f(R) gravity but we hope the results are sufficiently general for higher order polynomial gravity.« less

Large-scale magnetic topologies of early M dwarfs

NASA Astrophysics Data System (ADS)

Donati, J.-F.; Morin, J.; Petit, P.; Delfosse, X.; Forveille, T.; Aurière, M.; Cabanac, R.; Dintrans, B.; Fares, R.; Gastine, T.; Jardine, M. M.; Lignières, F.; Paletou, F.; Ramirez Velez, J. C.; Théado, S.

2008-10-01

We present here additional results of a spectropolarimetric survey of a small sample of stars ranging from spectral type M0 to M8 aimed at investigating observationally how dynamo processes operate in stars on both sides of the full convection threshold (spectral type M4). The present paper focuses on early M stars (M0-M3), that is above the full convection threshold. Applying tomographic imaging techniques to time series of rotationally modulated circularly polarized profiles collected with the NARVAL spectropolarimeter, we determine the rotation period and reconstruct the large-scale magnetic topologies of six early M dwarfs. We find that early-M stars preferentially host large-scale fields with dominantly toroidal and non-axisymmetric poloidal configurations, along with significant differential rotation (and long-term variability); only the lowest-mass star of our subsample is found to host an almost fully poloidal, mainly axisymmetric large-scale field resembling those found in mid-M dwarfs. This abrupt change in the large-scale magnetic topologies of M dwarfs (occurring at spectral type M3) has no related signature on X-ray luminosities (measuring the total amount of magnetic flux); it thus suggests that underlying dynamo processes become more efficient at producing large-scale fields (despite producing the same flux) at spectral types later than M3. We suspect that this change relates to the rapid decrease in the radiative cores of low-mass stars and to the simultaneous sharp increase of the convective turnover times (with decreasing stellar mass) that models predict to occur at M3; it may also be (at least partly) responsible for the reduced magnetic braking reported for fully convective stars. Based on observations obtained at the Télescope Bernard Lyot (TBL), operated by the Institut National des Science de l'Univers of the Centre National de la Recherche Scientifique of France. E-mail: donati@ast.obs-mip.fr (J-FD); jmorin@ast.obs-mip.fr (JM); petit@ast.obs-mip.fr (PP); xavier.delfosse@obs.ujf-grenoble.fr (XD); thierry.forveille@obs.ujf-grenoble.fr (TF); auriere@ast.obs-mip.fr (MA); remi.cabanac@ast.obs-mip.fr (RC); dintrans@ast.obs-mip.fr (BD); rfares@ast.obs-mip.fr (RF); tgastine@ast.obs-mip.fr (TG); mmj@st-and.ac.uk (MMJ); lignieres@ast.obs-mip.fr (FL); fpaletou@ast.obs-mip.fr (FP); julio.ramirez@obspm.fr (JCRV); sylvie.theado@ast.obs-mip.fr (ST)

Adrenaline and triiodothyronine modify the iron handling in the freshwater air-breathing fish Anabas testudineus Bloch: role of ferric reductase in iron acquisition.

PubMed

Rejitha, V; Peter, M C Subhash

2013-01-15

The effects of in vivo adrenaline and triiodothyronine (T(3)) on ferric reductase (FR) activity, a membrane-bound enzyme that reduces Fe(III) to Fe(II) iron, were studied in the organs of climbing perch (Anabas testudineus Bloch). Adrenaline injection (10 ng g(-1)) for 30 min produced significant inhibition of FR activity in the liver and kidney and that suggests a role for this stress hormone in iron acquisition in this fish. Short-term T(3) injection (40 ng g(-1)) reduced FR activity in the gills of fed fish but not in the unfed fish. Similar reduction of FR activity was also obtained in the intestine and kidney of fed fish after T(3) injection. Feeding produced pronounced decline in FR activity in the spleen but T(3) challenge in fed and unfed fish increased its activity in this iron storing organ and that point to the sensitivity of FR system to feeding activity. The in vitro effects of Fe on FR activity in the gill explants of freshwater fish showed correlations of FR with Na(+), K(+)-ATPase and H(+)-ATPase activities. Substantial increase in the FR activity was found in the gill explants incubated with all the tested doses of Fe(II) iron (1.80, 3.59 and 7.18 μM) and Fe(III) iron (1.25, 2.51 and 5.02 μM) and this indicate that FR and Na pump activity are positively correlated. On the contrary, substantial reduction of gill H(+)-ATPase activity was found in the gill explants incubated with Fe(II) iron and Fe(III) iron indicating that perch gills may not require a high acidic microenvironment for the reduction of Fe(III) iron. Accumulation of iron in the gill explants after Fe(III) iron incubation implies a direct relationship between Fe acquisition and FR activity in this tissue. The inverse correlation between FR activity and H(+)-ATPase activity in Fe(II) or Fe(III) loaded gills and the significant positive correlations of FR activity with total [Fe] content in the Fe(III) loaded gills substantiate that FR which shows sensitivity to sodium and proton pumps, has a vital role in Fe(II) and Fe(III) iron handling in this fish. Our data also provide evidence that adrenaline, T(3) and the feeding status are the vital factors that can regulate the storage and handling of iron in fish. Copyright © 2012 Elsevier Inc. All rights reserved.

Mapping cell populations in flow cytometry data for cross‐sample comparison using the Friedman–Rafsky test statistic as a distance measure

PubMed Central

Hsiao, Chiaowen; Liu, Mengya; Stanton, Rick; McGee, Monnie; Qian, Yu

2015-01-01

Abstract Flow cytometry (FCM) is a fluorescence‐based single‐cell experimental technology that is routinely applied in biomedical research for identifying cellular biomarkers of normal physiological responses and abnormal disease states. While many computational methods have been developed that focus on identifying cell populations in individual FCM samples, very few have addressed how the identified cell populations can be matched across samples for comparative analysis. This article presents FlowMap‐FR, a novel method for cell population mapping across FCM samples. FlowMap‐FR is based on the Friedman–Rafsky nonparametric test statistic (FR statistic), which quantifies the equivalence of multivariate distributions. As applied to FCM data by FlowMap‐FR, the FR statistic objectively quantifies the similarity between cell populations based on the shapes, sizes, and positions of fluorescence data distributions in the multidimensional feature space. To test and evaluate the performance of FlowMap‐FR, we simulated the kinds of biological and technical sample variations that are commonly observed in FCM data. The results show that FlowMap‐FR is able to effectively identify equivalent cell populations between samples under scenarios of proportion differences and modest position shifts. As a statistical test, FlowMap‐FR can be used to determine whether the expression of a cellular marker is statistically different between two cell populations, suggesting candidates for new cellular phenotypes by providing an objective statistical measure. In addition, FlowMap‐FR can indicate situations in which inappropriate splitting or merging of cell populations has occurred during gating procedures. We compared the FR statistic with the symmetric version of Kullback–Leibler divergence measure used in a previous population matching method with both simulated and real data. The FR statistic outperforms the symmetric version of KL‐distance in distinguishing equivalent from nonequivalent cell populations. FlowMap‐FR was also employed as a distance metric to match cell populations delineated by manual gating across 30 FCM samples from a benchmark FlowCAP data set. An F‐measure of 0.88 was obtained, indicating high precision and recall of the FR‐based population matching results. FlowMap‐FR has been implemented as a standalone R/Bioconductor package so that it can be easily incorporated into current FCM data analytical workflows. © 2015 International Society for Advancement of Cytometry PMID:26274018

A novel urinary long non-coding RNA transcript improves diagnostic accuracy in patients undergoing prostate biopsy.

PubMed

Zhang, Wei; Ren, Shan-Cheng; Shi, Xiao-Lei; Liu, Ya-Wei; Zhu, Ya-Sheng; Jing, Tai-Le; Wang, Fu-Bo; Chen, Rui; Xu, Chuan-Liang; Wang, Hui-Qing; Wang, Hai-Feng; Wang, Yan; Liu, Bing; Li, Yao-Ming; Fang, Zi-Yu; Guo, Fei; Lu, Xin; Shen, Dan; Gao, Xu; Hou, Jian-Guo; Sun, Ying-Hao

2015-05-01

Long non-coding RNA (LncRNA) PCA3 has been a well-established urine biomarker for the detection of prostate cancer (PCa). Our previous study showed a novel LncRNA FR0348383 is up-regulated in over 70% of PCa compared with matched benign tissues. The aim of this study was to evaluate the diagnostic value of urinary FR0348383 for men undergoing prostate biopsy due to elevated PSA (PSA > 4.0 ng/ml) and/or abnormal digital rectal examination (DRE). Post-DRE first-catch urine specimens prior to prostate biopsies were prospectively collected. After the whole transcriptome amplification, quantitative real time polymerase chain reaction was applied to quantify urine FR0348383 and PSA levels. The FR0348383 score was calculated as the ratio of PSA and FR0348383 mRNA (PSA mRNA/FR0348383 mRNA × 1000). The diagnostic value of FR0348383 score was evaluated by logistic regression and decision curve analysis. 213 cases with urine samples containing sufficient mRNA were included, 94 cases had serum PSA level 4.0-10.0 ng/ml. PCa was identified in 72 cases. An increasing FR0348383 score was correlated with an increasing probability of a positive biopsy (P < 0.001). Multivariable logistic analysis indicated FR0348383 score (P < 0.001), PSA (P = 0.004), age (P = 0.007), prostate volume (P < 0.001) were independent predictors of PCa. ROC analysis demonstrated FR0348383 score outperformed PSA, %free PSA, and PSA Density in the prediction of PCa in the subgroup of patients with grey area PSA (AUC: 0.815 vs. 0.562 vs. 0.599 vs. 0.645). When using a probability threshold of 30% in the grey zone cohort, The FR0348383 score would save 52.0% of avoidable biopsies without missing any high grade cancers. FR0348383 transcript in post-DRE urine may be a novel biomarker for detection of PCa with great diagnostic value, especially in the grey zone cohort. The application of FR0348383 score in clinical practice might avoid unnecessary prostate biopsies and increase the specificity of PCa diagnosis. © 2015 Wiley Periodicals, Inc.

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Low Transvalvular Flow Rate Predicts Mortality in Patients With Low-Gradient Aortic Stenosis Following Aortic Valve Intervention.

PubMed

Vamvakidou, Anastasia; Jin, Wenying; Danylenko, Oleksandr; Chahal, Navtej; Khattar, Rajdeep; Senior, Roxy

2018-03-09

This study aimed to assess the value of low transvalvular flow rate (FR) for the prediction of mortality compared with low stroke volume index (SVi) in patients with low-gradient (mean gradient: <40 mm Hg), low aortic valve area (<1 cm 2 ) aortic stenosis (AS) following aortic valve intervention. Transaortic FR defined as stroke volume/left ventricular ejection time is also a marker of flow; however, no data exist comparing the relative prognostic value of these 2 transvalvular flow markers in patients with low-gradient AS who had undergone valve intervention. We retrospectively followed prospectively assessed consecutive patients with low-gradient, low aortic valve area AS who underwent aortic valve intervention between 2010 and 2014 for all-cause mortality. Of the 218 patients with mean age 75 ± 12 years, 102 (46.8%) had low stroke volume index (SVi) (<35 ml/m 2 ), 95 (43.6%) had low FR (<200 ml/s), and 58 (26.6%) had low left ventricular ejection fraction <50%. The concordance between FR and SVi was 78.8% (p < 0.005). Over a median follow-up of 46.8 ± 21 months, 52 (23.9%) deaths occurred. Patients with low FR had significantly worse outcome compared with those with normal FR (p < 0.005). In patients with low SVi, a low FR conferred a worse outcome than a normal FR (p = 0.005), but FR status did not discriminate outcome in patients with normal SVi. By contrast, SVi did not discriminate survival either in patients with normal or low FR. Low FR was an independent predictor of mortality (p = 0.013) after adjusting for age, clinical prognostic factors, European System for Cardiac Operative Risk Evaluation II, dimensionless velocity index, left ventricular mass index, left ventricular ejection fraction, heart rate, time, type of aortic valve intervention, and SVi (p = 0.59). In patients with low-gradient, low valve area aortic stenosis undergoing aortic valve intervention, low FR, not low SVi, was an independent predictor of medium-term mortality. Copyright © 2018 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

The impact of tissue Doppler index E/e' ratio on instantaneous wave-free ratio.

PubMed

Arashi, Hiroyuki; Yamaguchi, Junichi; Ri, Tonre; Otsuki, Hisao; Nakao, Masashi; Kamishima, Kazuho; Jujo, Kentaro; Minami, Yuichiro; Ogawa, Hiroshi; Hagiwara, Nobuhisa

2018-03-01

The instantaneous wave-free ratio (iFR) is a vasodilator-free, invasive pressure wire index of the functional severity of coronary stenosis and is calculated under resting conditions. In a recent study, iFR was found to be more closely linked to coronary flow reserve (CFR) than fractional flow reserve (FFR). E/e' is a surrogate marker of left ventricular (LV) filling pressure and LV diastolic dysfunction. Coronary resting flow was found to be increased in patients with elevated E/e', and higher coronary resting flow was associated with lower CFR. Higher baseline coronary flow induces a greater loss of translesional pressure and may affect iFR. However, no reports have examined the impact of E/e' on iFR. The purpose of this study was to assess the relationship between iFR and E/e' compared with FFR. We retrospectively examined 103 consecutive patients (142 with stenosis) whose iFR, FFR, and E/e' were measured simultaneously. The mean age, LV mass index, and systolic blood pressure of patients with elevated E/e' were higher than those of patients with normal E/e'. Although no significant differences were observed in mean FFR values and % diameter stenosis, the mean iFR value in patients with elevated E/e' was significantly lower than that in patients with normal E/e'. The iFR was negatively correlated with E/e', while there was no correlation between FFR and E/e'. Multivariate analysis showed that E/e' and % diameter stenosis were independent determinants of iFR. E/e' ratio affects iFR values. Our results suggest that FFR mainly reflects the functional severity of the epicardial stenosis whereas iFR could potentially be influenced by not only epicardial stenosis but also other factors related to LV filling pressure or LV diastolic dysfunction. Further research is needed to understand the underlying mechanisms that influence the evaluation of iFR in patients with elevated E/e'. Copyright © 2017 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.

Real-time use of instantaneous wave-free ratio: results of the ADVISE in-practice: an international, multicenter evaluation of instantaneous wave-free ratio in clinical practice.

PubMed

Petraco, Ricardo; Al-Lamee, Rasha; Gotberg, Matthias; Sharp, Andrew; Hellig, Farrel; Nijjer, Sukhjinder S; Echavarria-Pinto, Mauro; van de Hoef, Tim P; Sen, Sayan; Tanaka, Nobuhiro; Van Belle, Eric; Bojara, Waldemar; Sakoda, Kunihiro; Mates, Martin; Indolfi, Ciro; De Rosa, Salvatore; Vrints, Christian J; Haine, Steven; Yokoi, Hiroyoshi; Ribichini, Flavio L; Meuwissen, Martjin; Matsuo, Hitoshi; Janssens, Luc; Katsumi, Ueno; Di Mario, Carlo; Escaned, Javier; Piek, Jan; Davies, Justin E

2014-11-01

To evaluate the first experience of real-time instantaneous wave-free ratio (iFR) measurement by clinicians. The iFR is a new vasodilator-free index of coronary stenosis severity, calculated as a trans-lesion pressure ratio during a specific period of baseline diastole, when distal resistance is lowest and stable. Because all previous studies have calculated iFR offline, the feasibility of real-time iFR measurement has never been assessed. Three hundred ninety-two stenoses with angiographically intermediate stenoses were included in this multicenter international analysis. Instantaneous wave-free ratio and fractional flow reserve (FFR) were performed in real time on commercially available consoles. The classification agreement of coronary stenoses between iFR and FFR was calculated. Instantaneous wave-free ratio and FFR maintain a close level of diagnostic agreement when both are measured by clinicians in real time (for a clinical 0.80 FFR cutoff: area under the receiver operating characteristic curve [ROC(AUC)] 0.87, classification match 80%, and optimal iFR cutoff 0.90; for a ischemic 0.75 FFR cutoff: iFR ROC(AUC) 0.90, classification match 88%, and optimal iFR cutoff 0.85; if the FFR 0.75-0.80 gray zone is accounted for: ROC(AUC) 0.93, classification match 92%). When iFR and FFR are evaluated together in a hybrid decision-making strategy, 61% of the population is spared from vasodilator while maintaining a 94% overall agreement with FFR lesion classification. When measured in real time, iFR maintains the close relationship to FFR reported in offline studies. These findings confirm the feasibility and reliability of real-time iFR calculation by clinicians. Copyright © 2014 The Author. Published by Elsevier Inc. All rights reserved.

Simplifying the assessment of coronary artery stenosis by enhancing instantaneous wave free ratio.

PubMed

Spagnoli, Vincent; Picard, Fabien; Tadros, Victor-Xavier; Cournoyer, Daniel; Doucet, Serge; Tanguay, Jean François; Gosselin, Gilbert; de Guise, Pierre; Gallo, Richard

2018-04-01

Instantaneous wave free ratio (iFR) does not require adenosine, but has a relatively wide intermediate range where functional assessment remains inconclusive. In this pilot study, we sought to enhance iFR through with the use of intracoronary (IC) saline (iFRs) and contrast media (iFRc) and determine whether these techniques correlated well with fractional flow reserve (FFR). Patients with coronary artery stenosis (CAS) associated with an iFR in the intermediate zone (≥0.86 and ≤0.93) were prospectively assessed with resting distal coronary pressure/aorta pressure (Pd/Pa), iFR, iFRs, iFRc and FFR. A total of 40 coronary lesions were studied (40 patients). Pearson correlation coefficients for FFR and iFR, FFR and iFRs, FFR and iFRc were respectively: 0.57 (P=0.0002), 0.80 (P<0.0001) and 0.77 (P<0.0001). Receiver-operating characteristic (ROC) curve analysis showed similar area under the curve (AUC) of iFRs and iFR [0.90 (95% CI: 0.76-1) vs. 0.89 (95% CI: 0.79-0.99), P=0.89]. Youden's index established cut-off values of ≤0.90 for iFR (sensitivity =91%, specificity =74%) and ≤0.78 for iFRs (sensitivity =73%, specificity =100%). In contrast, the AUC of iFRc was superior to the AUC of iFR [0.99 (95% CI: 0.98-1), P=0.049]. iFRc showed excellent accuracy and established cut-off values of ≤0.81 in predicting an FFR value of ≤0.80 (sensitivity =100%, specificity =93%). When iFR is in the intermediate zone, functional assessment of CAS by iFR is enhanced with the use of contrast media but not saline. This pilot study could be hypothesis generating for further study to enhance iFR specificity and sensibility.

Simplifying the assessment of coronary artery stenosis by enhancing instantaneous wave free ratio

PubMed Central

Spagnoli, Vincent; Picard, Fabien; Tadros, Victor-Xavier; Cournoyer, Daniel; Doucet, Serge; Tanguay, Jean François; Gosselin, Gilbert; de Guise, Pierre

2018-01-01

Background Instantaneous wave free ratio (iFR) does not require adenosine, but has a relatively wide intermediate range where functional assessment remains inconclusive. In this pilot study, we sought to enhance iFR through with the use of intracoronary (IC) saline (iFRs) and contrast media (iFRc) and determine whether these techniques correlated well with fractional flow reserve (FFR). Methods Patients with coronary artery stenosis (CAS) associated with an iFR in the intermediate zone (≥0.86 and ≤0.93) were prospectively assessed with resting distal coronary pressure/aorta pressure (Pd/Pa), iFR, iFRs, iFRc and FFR. Results A total of 40 coronary lesions were studied (40 patients). Pearson correlation coefficients for FFR and iFR, FFR and iFRs, FFR and iFRc were respectively: 0.57 (P=0.0002), 0.80 (P<0.0001) and 0.77 (P<0.0001). Receiver-operating characteristic (ROC) curve analysis showed similar area under the curve (AUC) of iFRs and iFR [0.90 (95% CI: 0.76–1) vs. 0.89 (95% CI: 0.79–0.99), P=0.89]. Youden’s index established cut-off values of ≤0.90 for iFR (sensitivity =91%, specificity =74%) and ≤0.78 for iFRs (sensitivity =73%, specificity =100%). In contrast, the AUC of iFRc was superior to the AUC of iFR [0.99 (95% CI: 0.98–1), P=0.049]. iFRc showed excellent accuracy and established cut-off values of ≤0.81 in predicting an FFR value of ≤0.80 (sensitivity =100%, specificity =93%). Conclusions When iFR is in the intermediate zone, functional assessment of CAS by iFR is enhanced with the use of contrast media but not saline. This pilot study could be hypothesis generating for further study to enhance iFR specificity and sensibility. PMID:29850406

Antibacterial, antioxidant, and topical anti-inflammatory activities of Bergia ammannioides: A wound-healing plant.

PubMed

Ezzat, Shahira M; Choucry, Mouchira A; Kandil, Zeinab A

2016-01-01

Despite the traditional use of Bergia ammannioides Henye ex Roth. (Elatinaceae) for the treatment of wounds in India, there is a scarcity of scientific data supporting this use. The objective of this study is to assess wound-healing potentiality of the plant, to study pharmacological activities that may contribute in eliminating wound complications, and to investigate the biologically active fractions. The ethanolic extract (EtOH) of the aerial parts was fractionated to obtain n-hexane (HxFr), chloroform (ClFr), ethyl acetate (EtFr), and n-butanol (BuOH) fractions. EtOH and its fractions were formulated in strength of 5 and 10% w/w ointment and tested for wound-healing activity using the excision model. The topical anti-inflammatory, in vitro antioxidant, and antibacterial activities were evaluated. HxFr and EtFr were chemically investigated to isolate their constituents. Application of EtOH, HxFr, and EtFr (10% w/w ointments) leads to 71.77, 85.62, and 81.29% healing of the wounds with an increase in the collagen content. HxFr had the strongest anti-inflammatory (64.5% potency relative to Voltaren®) and antibacterial activity (MIC = 104 μg/ml against Staphylococcus aureus), while EtFr showed the strongest antioxidant activity against DPPH, ABTS(•+), and super oxide radical with an IC50 value of 10.25 ± 0.01, 66.09 ± 0.76, and 167.33 ± 0.91 µg/ml, respectively. β-Sitosterol, lupeol, cyclolaudenol, and cycloartenol were isolated from HxFr. Quercetin, ellagic acid, kaempferol-3-O-α-l-rhamnoside, and quercetin-3-O-α-l-rhamnoside were isolated from EtFr. Our study presents scientific evidence for the efficacy of B. ammannioides in enhancing wound healing, and the first isolation of cyclolaudenol and cycloartenol from Bergia.

List of Participants

NASA Astrophysics Data System (ADS)

2011-09-01

AbeTakashiUniversity of Tokyotabe@nt.phys.s.u-tokyo.ac.jp AmusiaMironRacah Institute of Physics, Jerusalemamusia@vms.huji.ac.il BaldoMarcelloINFN Cataniabaldo@ct.infn.it BansalManiePanjab University, Chandigarhbansalmanni@gmail.com BarrancoFranciscoUniversity of Sevillebarranco@us.es BertschGeorgeUniversity of Washington, Seattlebertsch@u.washington.edu BhagwatAmeeyaCBS Mumbaiameeya@kth.se BorderieBernardIPN Orsayborderie@ipno.in2p3.fr CarbonellJaumeLPSC Grenoblejaume.carbonell@lpsc.in2p3.fr CarlsonJoeLos Alamos National Laboratorycarlson@lanl.gov ColòGianlucaINFN - Università degli Studi di Milanocolo@mi.infn.it DanielewiczPawelNSCL, Michigan State Universitydanielewicz@nscl.msu.edu DescouvemontPierreUniversité Libre de Bruxellespdesc@ulb.ac.be Dohet-EralyJérémyUniversité Libre de Bruxellesjdoheter@ulb.ac.be DraayerJerryLouisiana State Universitydraayer@lsu.edu DufourMarianneIPHC, Université de Strasbourgmarianne.dufour@ires.in2p3.fr DuguetThomasCEA Saclaythomas.duguet@cea.fr DukelskyJorgeCSIC Madriddukelsky@iem.cfmac.csic.es EbranJean-PaulCEA-DAM, Arpajonebran@ipno.in2p3.fr FreerMartinUniversity of Birminghamm.freer@bham.ac.uk FujiiShinichiroUniversity of Tokyosfujii@cns.s.u-tokyo.ac.jp FunakiYasuroRIKEN Nishina Center, Wakofunaki@riken.jp GrassoMarcellaIPN Orsaygrasso@ipno.in2p3.fr HaginoKouichiTohoku Universityhagino@nucl.phys.tohoku.ac.jp HansenHubertUniversité Claude Bernard Lyon 1hansen@ipnl.in2p3.fr HolzmannMarkusLPMMC Grenoblemarkus@lptl.jussieu.fr HoriuchiHisashiRCNP, Osaka Universityhoriuchi@rcnp.osaka-u.ac.jp HoriuchiWataruGSI Darmstadtw.horiuchi@gsi.de HupinGuillaumeGANIL, Caenhupin@ganil.fr JinMengHuazhong Normal University, Wuhanjinm@iopp.ccnu.edu.cn KamimuraMasayasuRIKEN Nishina Center, Wakomkamimura@riken.jp Kanada-En'yoYoshikoKyoto Universityyenyo@ruby.scphys.kyoto-u.ac.jp KatoKiyoshiHokkaido University, Sapporokato@nucl.sci.hokudai.ac.jp KawabataTakahiroKyoto Universitykawabata@scphys.kyoto-u.ac.jp KhanEliasIPN Orsaykhan@ipno.in2p3.fr KhodelVictorKurchatov Institute, Moscowvak@wuphys.wustl.edu KimuraMasaakiHokkaido University, Sapporomasaaki@nucl.sci.hokudai.ac.jp LacroixDenisGANIL, Caenlacroix@ganil.fr LiangHaozhaoPeking University, Beijinghzliang@pku.edu.cn MargueronJérômeIPN Orsayjerome.margueron@ipno.in2p3.fr MassotElisabethIPN Orsaymassot@ipno.in2p3.fr MengJiePeking University, Beijingmengj@pku.edu.cn MillerTomaszWarsaw University of Technologymillert@student.mini.pw.edu.pl MoghrabiKassemIPN Orsaymoghrabi@ipno.in2p3.fr NapolitaniPaoloIPN Orsaynapolita@ipno.in2p3.fr NeffThomasGSI Darmstadtt.neff@gsi.de NguyenVan GiaiIPN Orsaynguyen@ipno.in2p3.fr OtsukaTakaharuUniversity of Tokyootsuka@phys.s.u-tokyo.ac.jp PilletNathalie-MarieCEA-DAM, Arpajonnathalie.pillet@cea.fr QiChongKTH Stockholmchongq@kth.se RamananSunethraICTP Triestesramanan@ictp.it RingPeterTU Munichring@ph.tum.de Rios HuguetArnauUniversity of Surreya.rios@surrey.ac.uk RivetMarie-FranceIPN Orsayrivet@ipno.in2p3.fr RobledoLuisUniversidad Autonoma de Madridluis.robledo@uam.es Roca MazaXavierINFN Milanoxavier.roca.maza@mi.infn.it RöpkeGerdRostock Universitygerd.roepke@uni-rostock.de RowleyNeilIPN Orsayrowley@ipno.in2p3.fr SagawaHiroyukiUniversity of Aizusagawa@u-aizu.ac.jp SandulescuNicolaeIFIN-HH, Bucharestsandulescu@theory.nipne.ro SchuckPeterIPN Orsayschuck@ipno.in2p3.fr SedrakianArmenGoethe Universität Frankfurtsedrakian@th.physik.uni-frankfurt.de SeveryukhinAlexeyJINR Dubnasever@theor.jinr.ru SogoTakaakiIPN Orsaysogo@ipno.in2p3.fr SomàVittorioCEA Saclayvittorio.soma@cea.fr StrinatiGiancarloUniversità di Camerinogiancarlo.strinati@gmail.com SuharaTadahiroKyoto Universitysuhara@ruby.scphys.kyoto-u.ac.jp SukhoruchkinSergeiPetersburg Nuclear Physics Institutesergeis@pnpi.spb.ru SuzukiToruTokyo Metropolitan Universitysuzukitr@tmu.ac.jp SuzukiToshioNihon University, Tokyosuzuki@chs.nihon-u.ac.jp TarpanovDimitarINRNE, Sofiadimitert@yahoo.co.uk Tohsaki-SuzukiAkihiroOsaka Universitytohsaki@rcnp.osaka-u.ac.jp TypelStefanGSI Darmstadts.typel@gsi.de UesakaTomohiroUniversity of Tokyouesaka@cns.s.u-tokyo.ac.jp UrbanMichaelIPN Orsayurban@ipno.in2p3.fr Van IsackerPietGANIL Caenisacker@ganil.fr VigezziEnricoINFN Milanovigezzi@mi.infn.it ViñasXavierUniversitat de Barcelonaxavier@ecm.ub.es Vinh MauNicoleIPN Orsayvinhmau@ipno.in2p3.fr VitturiAndreaINFN Padovavitturi@pd.infn.it Von OertzenWolframHelmholtz Zentrum Berlinoertzen@helmholtz-berlin.de WambachJochenTechnische Universität Darmstadtjochen.wambach@physik.tu-darmstadt.de WlazłowskiGabrielWarsaw University of Technologygabrielw@if.pw.edu.pl YamadaTaiichiKanto Gakuin University, Yokohamayamada@kanto-gakuin.ac.jp YoshidaKenichiRIKEN Nishina Center, Wakokenichi.yoshida@riken.jp YoshidaSatoshiHosei University, Tokyos_yoshi@i.hosei.ac.jp

48 CFR 31.101 - Objectives.

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Selenium Supplementation Restores Innate and Humoral Immune Responses in Footrot-Affected Sheep

PubMed Central

Hall, Jean A.; Vorachek, William R.; Stewart, Whitney C.; Gorman, M. Elena; Mosher, Wayne D.; Pirelli, Gene J.; Bobe, Gerd

2013-01-01

Dietary selenium (Se) alters whole-blood Se concentrations in sheep, dependent upon Se source and dosage administered, but little is known about effects on immune function. We used footrot (FR) as a disease model to test the effects of supranutritional Se supplementation on immune function. To determine the effect of Se-source (organic Se-yeast, inorganic Na-selenite or Na-selenate) and Se-dosage (1, 3, 5 times FDA-permitted level) on FR severity, 120 ewes with and 120 ewes without FR were drenched weekly for 62 weeks with different Se sources and dosages (30 ewes/treatment group). Innate immunity was evaluated after 62 weeks of supplementation by measuring neutrophil bacterial killing ability. Adaptive immune function was evaluated by immunizing sheep with keyhole limpet hemocyanin (KLH). The antibody titer and delayed-type hypersensitivity skin test to KLH were used to assess humoral immunity and cell-mediated immunity, respectively. At baseline, FR-affected ewes had lower whole-blood and serum-Se concentrations; this difference was not observed after Se supplementation. Se supplementation increased neutrophil bacterial killing percentages in FR-affected sheep to percentages observed in supplemented and non-supplemented healthy sheep. Similarly, Se supplementation increased KLH antibody titers in FR-affected sheep to titers observed in healthy sheep. FR-affected sheep demonstrated suppressed cell-mediated immunity at 24 hours after intradermal KLH challenge, although there was no improvement with Se supplementation. We did not consistently prevent nor improve recovery from FR over the 62 week Se-treatment period. In conclusion, Se supplementation does not prevent FR, but does restore innate and humoral immune functions negatively affected by FR. PMID:24340044

Resistance training attenuates fat mass regain after weight loss in ovariectomized rats.

PubMed

Pighon, Abdolnaser; Paquette, Amélie; Barsalani, Razieh; Chapados, Natalie Ann; Rabasa-Lhoret, Rémi; Yasari, Siham; Prud'homme, Denis; Lavoie, Jean-Marc

2009-09-20

The aim of the present study was to investigate the effects of maintaining only one of the two components of a food restriction (FR)+resistance training (RT) regimen on the regain of body weight and fat mass (liver and adipocytes) in ovariectomized (Ovx) rats. Five week Ovx rats were submitted to a weight loss program consisting of a 26% FR combined with RT (OvxFR+RT) for 8 weeks. RT consisted of climbing a 1.5m vertical grid with a load attached to the tail, 20-40 times with progressively increasing loads 4 times/week. Following this weight loss intervention, OvxFR+RT rats were sub-divided into 3 groups for an additional 5 weeks: 2 groups went back to a normal ad libitum feeding with or without RT and the other group kept only FR. Combined FR+RT program in Ovx rats led to lower body mass gain, liver triacylglycerol (TAG) levels, and fat mass gain compared to sedentary normally fed Ovx rats (P<0.01). Stopping both FR and RT over a 5 week period resulted in the regain of body weight, intra-abdominal fat pad weight and liver TAG (P<0.01). When only FR was maintained, the regain of body and fat pad weight as well as liver and plasma TAG concentrations was completely prevented. However, when only RT was maintained, regain in the aforementioned parameters was attenuated but not prevented (P<0.05). It is concluded that following a FR+RT weight loss program, continuation of only RT constitutes an asset to attenuate body weight and fat mass regain in Ovx rats; although the impact is less than the maintaining FR alone. These results suggest that, in post-menopausal women, RT is a positive strategy to reduce body weight and fat mass relapse.

Impact of food restriction and cocaine on locomotion in ghrelin- and ghrelin-receptor knockout mice.

PubMed

Clifford, Shane; Zeckler, Rosie Albarran; Buckman, Sam; Thompson, Jeff; Hart, Nigel; Wellman, Paul J; Smith, Roy G

2011-07-01

Food restriction (FR) augments the behavioral and reinforcing effects of psychomotor stimulants such as cocaine or amphetamine; effects that may be related to the capacity of FR to increase plasma levels of ghrelin (GHR), a 28-amino acid orexigenenic peptide linked to activation of brain dopamine systems. The present study used wild-type (WT) mice or mutant mice sustaining knockout of either GHR [GHR((-/-)) ] or of the growth hormone secretagogue receptor [GHS-R((-/-)) ] and subjected to FR or not to evaluate the role of GHR and GHS-R in cocaine-stimulated locomotion. WT, GHR((-/-)) , and GHS-R((-/-)) mice were either restricted to 60% of baseline caloric intake or allowed to free-feed (FF). Mice were treated with 0, 1.25, 2.5 and 5.0 mg/kg cocaine on separate test days (in random dose order) and forward locomotion was recorded on each drug day for 45 minutes after drug dosing. Food (and water) was available immediately after (but not during) each activity test. For FF mice, there was no interaction between cocaine and GHR status on locomotion. FR-WT mice treated with saline exhibited significant increases in anticipatory locomotion (relative to FF-WT mice), whereas FR-GHS-R((-/-)) mice did not. Cocaine significantly increased locomotion in FR-GHR((-/-)) and FR-GHS-R((-/-)) mice to the levels noted in FR-WT mice. These results suggest that GHS-R activity, but not GHR activity, is required for FR to augment food-associated anticipatory locomotion, but do not support the contention that GHR pathways are required for the capacity of FR to augment the acute effect of cocaine on locomotion. © 2010 The Authors, Addiction Biology © 2010 Society for the Study of Addiction.

Higher whole-blood selenium is associated with improved immune responses in footrot-affected sheep.

PubMed

Hall, Jean A; Sendek, Rachel L; Chinn, Rachel M; Bailey, D Paul; Thonstad, Katie N; Wang, Yongqiang; Forsberg, Neil E; Vorachek, William R; Stang, Bernadette V; Van Saun, Robert J; Bobe, Gerd

2011-09-06

We reported previously that sheep affected with footrot (FR) have lower whole-blood selenium (WB-Se) concentrations and that parenteral Se-supplementation in conjunction with routine control practices accelerates recovery from FR. The purpose of this follow-up study was to investigate the mechanisms by which Se facilitates recovery from FR. Sheep affected with FR (n = 38) were injected monthly for 15 months with either 5 mg Se (FR-Se) or saline (FR-Sal), whereas 19 healthy sheep received no treatment. Adaptive immune function was evaluated after 3 months of Se supplementation by immunizing all sheep with a novel protein, keyhole limpet hemocyanin (KLH). The antibody titer and delayed-type hypersensitivity (DTH) skin test to KLH were used to assess humoral immunity and cell-mediated immunity, respectively. Innate immunity was evaluated after 3 months of Se supplementation by measuring intradermal responses to histamine 30 min after injection compared to KLH and saline, and after 15 months of Se supplementation by isolating neutrophils and measuring their bacterial killing ability and relative abundance of mRNA for genes associated with neutrophil migration. Compared to healthy sheep, immune responses to a novel protein were suppressed in FR-affected sheep with smaller decreases in FR-affected sheep that received Se or had WB-Se concentrations above 250 ng/mL at the time of the immune assays. Neutrophil function was suppressed in FR-affected sheep, but was not changed by Se supplementation or WB-Se status. Sheep FR is associated with depressed immune responses to a novel protein, which may be partly restored by improving WB-Se status (> 250 ng/mL).

Higher whole-blood selenium is associated with improved immune responses in footrot-affected sheep

PubMed Central

2011-01-01

We reported previously that sheep affected with footrot (FR) have lower whole-blood selenium (WB-Se) concentrations and that parenteral Se-supplementation in conjunction with routine control practices accelerates recovery from FR. The purpose of this follow-up study was to investigate the mechanisms by which Se facilitates recovery from FR. Sheep affected with FR (n = 38) were injected monthly for 15 months with either 5 mg Se (FR-Se) or saline (FR-Sal), whereas 19 healthy sheep received no treatment. Adaptive immune function was evaluated after 3 months of Se supplementation by immunizing all sheep with a novel protein, keyhole limpet hemocyanin (KLH). The antibody titer and delayed-type hypersensitivity (DTH) skin test to KLH were used to assess humoral immunity and cell-mediated immunity, respectively. Innate immunity was evaluated after 3 months of Se supplementation by measuring intradermal responses to histamine 30 min after injection compared to KLH and saline, and after 15 months of Se supplementation by isolating neutrophils and measuring their bacterial killing ability and relative abundance of mRNA for genes associated with neutrophil migration. Compared to healthy sheep, immune responses to a novel protein were suppressed in FR-affected sheep with smaller decreases in FR-affected sheep that received Se or had WB-Se concentrations above 250 ng/mL at the time of the immune assays. Neutrophil function was suppressed in FR-affected sheep, but was not changed by Se supplementation or WB-Se status. Sheep FR is associated with depressed immune responses to a novel protein, which may be partly restored by improving WB-Se status (> 250 ng/mL). PMID:21896161

Feasible and technical aspects of transcatheter arterial chemoembolization for non-resectable hepatocellular carcinoma using a 3.5-French catheter system.

PubMed

Yagyu, Yukinobu; Tsurusaki, Masakatsu; Kamiyama, Kazutoshi; Kitagaki, Hajime; Murakami, Takamichi

2014-12-01

To evaluate the feasibility and technical aspects of transcatheter arterial chemoembolization (TACE) for non-resectable hepatocellular carcinoma (HCC) using a 3.5-French (Fr) catheter system. This study included 328 consecutive cases of HCC among 232 patients who underwent TACE procedures using both a 3.5-Fr catheter system and a microcatheter fitted to a 3.5-Fr system between April 2009 and November 2011. We assessed the ability to reach the catheter into the proper hepatic artery (PHA), main hepatic branch, segmental artery, and subsegmental or sub-subsegmental artery. The feasibility was rated according to the following factors: (1) the number of arteries that could be used to reach the target artery/total number of procedures using the 3.5-Fr system, (2) the rate of successful completion of the procedures without changing over to the 4-Fr system and (3) the reasons for changing over the 4-Fr system. TACE of the PHA (27 sessions), RHA/LHA (103 sessions), segmental (31 sessions), or subsegmental/sub-subsegmental arteries (162 sessions) was performed. The rate of successfully reaching the target artery using the 3.5-Fr system was 93% (306/328 sessions). We were unable to reach the target artery in 22 sessions, including 11/8/3 procedures targeting the sub-subsegmental artery, subsegmental artery, and RHA/LHA, respectively. We changed over to the 4-Fr system in six sessions; therefore, the rate of successful completion of the procedures without changing over to the 4-Fr system was 98% (322/328 sessions). TACE of the target artery can be successfully performed using the 3.5-Fr system in most patients with HCC.

7 CFR 319.41 - Notice of quarantine.

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Neurocognition and symptoms identify links between facial recognition and emotion processing in schizophrenia: Meta-analytic findings

PubMed Central

Ventura, Joseph; Wood, Rachel C.; Jimenez, Amy M.; Hellemann, Gerhard S.

2014-01-01

Background In schizophrenia patients, one of the most commonly studied deficits of social cognition is emotion processing (EP), which has documented links to facial recognition (FR). But, how are deficits in facial recognition linked to emotion processing deficits? Can neurocognitive and symptom correlates of FR and EP help differentiate the unique contribution of FR to the domain of social cognition? Methods A meta-analysis of 102 studies (combined n = 4826) in schizophrenia patients was conducted to determine the magnitude and pattern of relationships between facial recognition, emotion processing, neurocognition, and type of symptom. Results Meta-analytic results indicated that facial recognition and emotion processing are strongly interrelated (r = .51). In addition, the relationship between FR and EP through voice prosody (r = .58) is as strong as the relationship between FR and EP based on facial stimuli (r = .53). Further, the relationship between emotion recognition, neurocognition, and symptoms is independent of the emotion processing modality – facial stimuli and voice prosody. Discussion The association between FR and EP that occurs through voice prosody suggests that FR is a fundamental cognitive process. The observed links between FR and EP might be due to bottom-up associations between neurocognition and EP, and not simply because most emotion recognition tasks use visual facial stimuli. In addition, links with symptoms, especially negative symptoms and disorganization, suggest possible symptom mechanisms that contribute to FR and EP deficits. PMID:24268469

Neurocognition and symptoms identify links between facial recognition and emotion processing in schizophrenia: meta-analytic findings.

PubMed

Ventura, Joseph; Wood, Rachel C; Jimenez, Amy M; Hellemann, Gerhard S

2013-12-01

In schizophrenia patients, one of the most commonly studied deficits of social cognition is emotion processing (EP), which has documented links to facial recognition (FR). But, how are deficits in facial recognition linked to emotion processing deficits? Can neurocognitive and symptom correlates of FR and EP help differentiate the unique contribution of FR to the domain of social cognition? A meta-analysis of 102 studies (combined n=4826) in schizophrenia patients was conducted to determine the magnitude and pattern of relationships between facial recognition, emotion processing, neurocognition, and type of symptom. Meta-analytic results indicated that facial recognition and emotion processing are strongly interrelated (r=.51). In addition, the relationship between FR and EP through voice prosody (r=.58) is as strong as the relationship between FR and EP based on facial stimuli (r=.53). Further, the relationship between emotion recognition, neurocognition, and symptoms is independent of the emotion processing modality - facial stimuli and voice prosody. The association between FR and EP that occurs through voice prosody suggests that FR is a fundamental cognitive process. The observed links between FR and EP might be due to bottom-up associations between neurocognition and EP, and not simply because most emotion recognition tasks use visual facial stimuli. In addition, links with symptoms, especially negative symptoms and disorganization, suggest possible symptom mechanisms that contribute to FR and EP deficits. © 2013 Elsevier B.V. All rights reserved.

Reduction of FR900525 using an S-(2-aminoethyl) l-cysteine-resistant mutant.

PubMed

Shimizu, Shiho; Futase, Ayako; Yokoyama, Tatsuya; Ueda, Satoshi; Honda, Hiroyuki

2017-06-01

FK506 (tacrolimus), a macrolide compound with immunosuppressant activity, has been proven to have clinical importance and has been manufactured industrially since 1993 by using mutants with high FK506-production ability; these mutants have been developed from the wild strain Streptomyces tsukubaensis No. 9993. FR900525 is one of the by-products of FK506 production. However, there was no effective industrial method to separate FR900525 from FK506 due to the structural similarity between the two compounds. Therefore, reducing the level of FR900525 was a serious problem in the industrial strain A. In this study, we aimed to reduce the FR900525 production. We first determined that pipecolic acid level was a critical parameter for controlling FR900525 production in strain A. S-(2-Aminoethyl) l-cysteine (AEC)-resistant mutants has been reported to increase lysine productivity successfully in a variety of lysine-producing microorganisms. Therefore, next, we applied a selection of AEC-resistant mutants to enhance pipecolic acid biosynthesis. Finally, four AEC-resistant mutants were obtained from strain A using ultraviolet irradiation, and three of them showed less FR900525 productivity compared to the parental strain A. Our findings indicated that AEC resistance was effective phenotype marker for increasing pipecolic acid productivity and for reducing FR900525 production in S. tsukubaensis. Thus, our study provides an efficient method for reducing FR90025 level during FK506 biosynthesis. Copyright © 2017 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved.

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Trichomonas vaginalis Flavin Reductase 1 and its Role in Metronidazole Resistance

PubMed Central

Leitsch, David; Janssen, Brian D.; Kolarich, Daniel; Johnson, Patricia J.; Duchêne, Michael

2015-01-01

Summary The enzyme flavin reductase 1 (FR1) from Trichomonas vaginalis, formerly known as NADPH oxidase, was isolated and identified. Flavin reductase is part of the antioxidative defense in T. vaginalis and indirectly reduces molecular oxygen to hydrogen peroxide via free flavins. Importantly, a reduced or absent flavin reductase activity has been reported in metronidazole-resistant T. vaginalis, resulting in elevated intracellular oxygen levels and futile cycling of metronidazole. Interestingly, FR1 has no close homologue in any other sequenced genome, but seven full-length and three truncated isoforms exist in the T. vaginalis genome. However, out of these, only FR1 has an affinity for flavins, i.e. FMN, FAD, and riboflavin, which is high enough to be of physiological relevance. Although there are no relevant changes in the gene sequence or any alterations of the predicted FR1-mRNA structure in any of the strains studied, FR1 is not expressed in highly metronidazole-resistant strains. Transfection of a metronidazole-resistant clinical isolate (B7268), which does not express any detectable amounts of FR, with a plasmid bearing a functional FR1 gene nearly completely restored metronidazole sensitivity. Our results indicate that FR1 has a significant role in the emergence of metronidazole resistance in T. vaginalis. PMID:24256032

Frühe Stresserfahrungen und Krankheitsvulnerabilität

PubMed Central

Entringer, Sonja; Buss, Claudia; Heim, Christine

2016-01-01

Zusammenfassung Hintergrund Das stetig wachsende Forschungsgebiet der “Frühe[n] Programmierung von Krankheit und Gesundheit” untersucht, inwieweit die individuelle Vulnerabilität für die Entstehung verschiedenster Erkrankungen über die Lebensspanne bereits während der frühen Entwicklung beeinflusst wird. Ziele der Arbeit In der vorliegenden Übersichtsarbeit werden das Konzept der frühen Programmierung von Krankheitsvulnerabilität erläutert sowie Befunde zu den Folgen frühkindlicher Traumatisierung und pränataler Stressexposition zusammenfassend dargestellt. Es werden außerdem biologische Mechanismen diskutiert, die das erhöhte Krankheitsrisiko nach lebensgeschichtlich früher Stresserfahrungen vermitteln. Die Möglichkeit der transgenerationalen Transmission frühkindlicher Erfahrungen an die nächste Generation und die zugrundeliegenden Mechanismen dieser Übertragung werden ebenfalls vorgestellt. Fazit Die Befundlage zu Stresserfahrungen im frühen Leben und der Entstehung von psychischen und körperlichen Störungen über die Lebensspanne wächst stetig. Die Mechanismen werden derzeit weiter bis hin zur molekularbiologischen und epigenetischen Ebene erforscht. Hier ergeben sich ganz neue Perspektiven, welche die Präzision klinischer Diagnostik und den Erfolg von Interventionen erheblich verbessern könnten. Momentan existiert jedoch noch ein erheblicher Mangel an Translation zwischen diesen Forschungserkenntnissen und deren Anwendung in der klinischen Versorgung. PMID:27604117

Diet Modifies Colonic Microbiota and CD4+ T Cell Repertoire to Induce Flares of Colitis in Mice With Myeloid-cell Expression of Interleukin 23.

PubMed

Chen, Lili; He, Zhengxiang; Iuga, Alina Cornelia; Martins Filho, Sebastião N; Faith, Jeremiah J; Clemente, Jose C; Deshpande, Madhura; Jayaprakash, Anitha; Colombel, Jean-Frederic; Lafaille, Juan J; Sachidanandam, Ravi; Furtado, Glaucia C; Lira, Sergio A

2018-06-14

Several studies have shown that signaling via the interleukin 23 (IL23) receptor is required for development of colitis. We studied the roles of IL23, dietary factors, alterations to the microbiota, and T cells in development and progression of colitis in mice. All mice were maintained on lab diet 5053, unless otherwise noted. We generated mice that express IL23 in CX3CR1-positive myeloid cells (R23FR mice) upon cyclic administration of tamoxifen dissolved in diet 2019. Diet 2019 and 5053 have minor differences in the overall composition of protein, fat, fiber, minerals, and vitamins. CX3CR1 CreER mice (FR mice) were used as controls. Some mice were given antibiotics and others were raised in a germ-free environment. Intestinal tissues were collected and analyzed by histology and flow cytometry. Feces were collected and analyzed by 16S rDNA sequencing. Feces from C57/Bl6, R23FR, or FR mice were fed to FR and R23FR germ-free mice in microbiota transplant experiments. We also performed studies with R23FR/Rag -/- , R23FR/Mu -/- , and R23FR/Tcrd -/- mice. R23FR mice were given injections of antibodies against CD4 or CD8 to deplete T cells. Mesenteric lymph nodes and large intestine CD4 + cells from R23FR or FR mice in remission from colitis were transferred into Rag -/- mice. CD4 + cells were isolated from donor R23FR mice and recipient Rag -/- mice, and T-cell receptor sequences were determined. Expression of IL23 led to development of a relapsing-remitting colitis that was dependent on the microbiota and CD4 + T cells. The relapses were caused by switching from the conventional diet used in our facility (diet 5053) to the diet 2019, and were not dependent on tamoxifen after the first cycle. The switch in the diet modified the microbiota, but did not alter levels of IL23 in intestinal tissues, compared to mice that remained on the conventional diet. Mesenteric lymph nodes and large intestine CD4 + cells from R23FR mice in remission, but not from FR mice, induced colitis after transfer into Rag -/- mice, but only when these mice were placed on the diet 2019. The CD4 + T-cell receptor repertoire of Rag -/- mice with colitis (fed the 2019 diet) was less diverse than that from donor mice and Rag -/- mice without colitis (fed the 5053 diet), due to expansion of dominant T-cell clones. We developed mice that express IL23 in CX3CR1-positive myeloid cells (R23FR mice) and found they are more susceptible to diet-induced colitis than mice that do not express IL23. The R23FR mice have a population of CD4 + T cells that becomes activated in response to dietary changes and alterations to the intestinal microbiota. The results indicate that alterations in the diet, intestinal microbiota, and IL23 signaling can contribute to pathogenesis of inflammatory bowel disease. Copyright © 2018 AGA Institute. Published by Elsevier Inc. All rights reserved.

40 CFR 271.1 - Purpose and scope.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Methyl Bromide 54 FR 41402-408 Apr. 6, 1990. Dec. 11, 1989 Listing Certain Hydrocarbons Produced by Free Radical Catalyzed Processes 54 FR 50968-978 June 11, 1990. Mar. 29, 1990 Toxicity characteristic 55 FR...

40 CFR 271.1 - Purpose and scope.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Methyl Bromide 54 FR 41402-408 Apr. 6, 1990. Dec. 11, 1989 Listing Certain Hydrocarbons Produced by Free Radical Catalyzed Processes 54 FR 50968-978 June 11, 1990. Mar. 29, 1990 Toxicity characteristic 55 FR...

49 CFR 390.17 - Additional equipment and accessories.

Code of Federal Regulations, 2010 CFR

2010-10-01

... equipment and accessories, not inconsistent with or prohibited by this subchapter, provided such equipment... are used. [53 FR 18052, May 19, 1988, as amended at 60 FR 38744, July 28, 1995. Redesignated at 65 FR...

75 FR 2560 - Issuance of Permits

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-15

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75 FR 6151 - Chartering and Field of Membership for Federal Credit Unions

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2010-02-08

... the terms ``rural district'' and ``in danger of insolvency'' for emergency merger purposes. 74 FR... the term ``in danger of insolvency'' for emergency merger purposes. 74 FR 68722 (December 29, 2009...

47 CFR 74.784 - Rebroadcasts.

Code of Federal Regulations, 2013 CFR

2013-10-01

... the station whose signals or programs are proposed to be retransmitted. The FCC, Attention: Video.... 325) [28 FR 13722, Dec. 14, 1963, as amended at 47 FR 21502, May 18, 1982; 52 FR 31405, Aug. 20, 1987...

47 CFR 74.784 - Rebroadcasts.

Code of Federal Regulations, 2014 CFR

2014-10-01

... the station whose signals or programs are proposed to be retransmitted. The FCC, Attention: Video.... 325) [28 FR 13722, Dec. 14, 1963, as amended at 47 FR 21502, May 18, 1982; 52 FR 31405, Aug. 20, 1987...

47 CFR 74.784 - Rebroadcasts.

Code of Federal Regulations, 2011 CFR

2011-10-01

... the station whose signals or programs are proposed to be retransmitted. The FCC, Attention: Video.... 325) [28 FR 13722, Dec. 14, 1963, as amended at 47 FR 21502, May 18, 1982; 52 FR 31405, Aug. 20, 1987...

47 CFR 51.5 - Terms and definitions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... voice, data, graphics or video telecommunications using any technology. Arbitration, final offer. Final... 1344, Jan. 10, 2000; 65 FR 2550, Jan. 18, 2000; 65 FR 54438, Sept. 8, 2000; 66 FR 43521, Aug. 20, 2001...

47 CFR 74.784 - Rebroadcasts.

Code of Federal Regulations, 2010 CFR

2010-10-01

... the station whose signals or programs are proposed to be retransmitted. The FCC, Attention: Video.... 325) [28 FR 13722, Dec. 14, 1963, as amended at 47 FR 21502, May 18, 1982; 52 FR 31405, Aug. 20, 1987...

47 CFR 74.784 - Rebroadcasts.

Code of Federal Regulations, 2012 CFR

2012-10-01

... the station whose signals or programs are proposed to be retransmitted. The FCC, Attention: Video.... 325) [28 FR 13722, Dec. 14, 1963, as amended at 47 FR 21502, May 18, 1982; 52 FR 31405, Aug. 20, 1987...

38 CFR 17.40 - Additional services for indigents.

Code of Federal Regulations, 2010 CFR

2010-07-01

... services, including haircutting and shaving necessary for hygienic reasons. [33 FR 5299, Apr. 3, 1968, as amended at 47 FR 58247, Dec. 30, 1982. Redesignated at 61 FR 21965, May 13, 1996] Examinations and...

Response requirement and increases in accuracy produced by stimulant drugs in a 5-choice serial reaction-time task in rats.

PubMed

Koffarnus, Mikhail N; Katz, Jonathan L

2011-02-01

Increased signal-detection accuracy on the 5-choice serial reaction time (5-CSRT) task has been shown with drugs that are useful clinically in treating attention deficit hyperactivity disorder (ADHD), but these increases are often small and/or unreliable. By reducing the reinforcer frequency, it may be possible to increase the sensitivity of this task to pharmacologically induced improvements in accuracy. Rats were trained to respond on the 5-CSRT task on a fixed ratio (FR) 1, FR 3, or FR 10 schedule of reinforcement. Drugs that were and were not expected to enhance performance were then administered before experimental sessions. Significant increases in accuracy of signal detection were not typically obtained under the FR 1 schedule with any drug. However, d-amphetamine, methylphenidate, and nicotine typically increased accuracy under the FR 3 and FR 10 schedules. Increasing the FR requirement in the 5-CSRT task increases the likelihood of a positive result with clinically effective drugs, and may more closely resemble conditions in children with attention deficits.

Radiation-grafting of flame retardants on flax fabrics - A comparison between different flame retardant structures

NASA Astrophysics Data System (ADS)

Teixeira, Marie; Sonnier, Rodolphe; Otazaghine, Belkacem; Ferry, Laurent; Aubert, Mélanie; Tirri, Teija; Wilén, Carl-Eric; Rouif, Sophie

2018-04-01

Three unsaturated compounds bearing respectively phosphate, aryl bromide and sulfenamide moieties were used as flame retardants (FR) for flax fabrics. Due to the presence of carbon-carbon double bonds, radiation-grafting was considered to covalently bond these FR onto fiber structure. Grafting efficiency and location of FR molecules were investigated by weight measurements and SEM-EDX observations. Flammability and especially self-extinguishment were assessed by thermogravimetric analysis, pyrolysis-combustion flow calorimetry and a non-standardized fire test already used in previous studies. All FRs were able to diffuse into elementary fiber bulk. Nevertheless only the phosphonated monomer (noted FR-P) was significantly grafted onto flax. Self-extinguishment was obtained for fabrics containing at least around 0.5 wt% of phosphorus. On the contrary the FR content of flax fibers after radiation-grafting procedure and washing was negligible for FR-S and FR-Br, evidencing that these molecules have not been grafted upon irradiation. Moreover, the combination of these molecules prevents the radiation-grafting of other molecules which showed good grafting rate when used alone.

An optimized fluorescent probe for visualizing glutamate neurotransmission.

PubMed

Marvin, Jonathan S; Borghuis, Bart G; Tian, Lin; Cichon, Joseph; Harnett, Mark T; Akerboom, Jasper; Gordus, Andrew; Renninger, Sabine L; Chen, Tsai-Wen; Bargmann, Cornelia I; Orger, Michael B; Schreiter, Eric R; Demb, Jonathan B; Gan, Wen-Biao; Hires, S Andrew; Looger, Loren L

2013-02-01

We describe an intensity-based glutamate-sensing fluorescent reporter (iGluSnFR) with signal-to-noise ratio and kinetics appropriate for in vivo imaging. We engineered iGluSnFR in vitro to maximize its fluorescence change, and we validated its utility for visualizing glutamate release by neurons and astrocytes in increasingly intact neurological systems. In hippocampal culture, iGluSnFR detected single field stimulus-evoked glutamate release events. In pyramidal neurons in acute brain slices, glutamate uncaging at single spines showed that iGluSnFR responds robustly and specifically to glutamate in situ, and responses correlate with voltage changes. In mouse retina, iGluSnFR-expressing neurons showed intact light-evoked excitatory currents, and the sensor revealed tonic glutamate signaling in response to light stimuli. In worms, glutamate signals preceded and predicted postsynaptic calcium transients. In zebrafish, iGluSnFR revealed spatial organization of direction-selective synaptic activity in the optic tectum. Finally, in mouse forelimb motor cortex, iGluSnFR expression in layer V pyramidal neurons revealed task-dependent single-spine activity during running.

76 FR 1409 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-10

... 17) can be deleted. The records covered by this system are also covered by Defense Finance and Accounting Service records notice T7332, Defense Debt Management System (February 19, 2009, 74 FR 7665). [FR...

49 CFR 385.1 - Purpose and scope.

Code of Federal Regulations, 2013 CFR

2013-10-01

... operating a CMV. (b) This part establishes the safety assurance program for a new entrant motor carrier... Regulations (FMCSRs). [65 FR 50934, Aug. 22, 2000, as amended at 67 FR 31982, May 13, 2002; 69 FR 39366, June...

49 CFR 385.1 - Purpose and scope.

Code of Federal Regulations, 2014 CFR

2014-10-01

... operating a CMV. (b) This part establishes the safety assurance program for a new entrant motor carrier... Regulations (FMCSRs). [65 FR 50934, Aug. 22, 2000, as amended at 67 FR 31982, May 13, 2002; 69 FR 39366, June...

49 CFR 385.1 - Purpose and scope.

Code of Federal Regulations, 2012 CFR

2012-10-01

... operating a CMV. (b) This part establishes the safety assurance program for a new entrant motor carrier... Regulations (FMCSRs). [65 FR 50934, Aug. 22, 2000, as amended at 67 FR 31982, May 13, 2002; 69 FR 39366, June...

24 CFR 941.101 - Purpose and scope.

Code of Federal Regulations, 2011 CFR

2011-04-01

... housing residents over the long term and have the lowest possible life cycle costs, taking into account.... [61 FR 38016, July 22, 1996, as amended at 64 FR 13511, Mar. 19, 1999] Effective Date Note: At 61 FR...

24 CFR 941.101 - Purpose and scope.

Code of Federal Regulations, 2012 CFR

2012-04-01

... housing residents over the long term and have the lowest possible life cycle costs, taking into account.... [61 FR 38016, July 22, 1996, as amended at 64 FR 13511, Mar. 19, 1999] Effective Date Note: At 61 FR...

24 CFR 941.101 - Purpose and scope.

Code of Federal Regulations, 2013 CFR

2013-04-01

... housing residents over the long term and have the lowest possible life cycle costs, taking into account.... [61 FR 38016, July 22, 1996, as amended at 64 FR 13511, Mar. 19, 1999] Effective Date Note: At 61 FR...

78 FR 73884 - Notice Pursuant to the National Cooperative Research and Production Act of 1993; National...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-09

..., Blackhawk Management, Houston, TX; Blue Juice, Inc., San Rafael, CA; Engineering and Management Executives... FR 52787). Patricia A. Brink, Director of Civil Enforcement, Antitrust Division. [FR Doc. 2013-29272...

48 CFR 22.1304 - Procedures.

Code of Federal Regulations, 2010 CFR

2010-10-01

...-100A Report, the contracting officer may— (a) Query the Department of Labor's VETS-100 Database via the... the database. [66 FR 53488, Oct. 22, 2001, as amended at 71 FR 67779, Nov. 22, 2006; 75 FR 60251, Sept...

48 CFR 22.1304 - Procedures.

Code of Federal Regulations, 2011 CFR

2011-10-01

...-100A Report, the contracting officer may— (a) Query the Department of Labor's VETS-100 Database via the... the database. [66 FR 53488, Oct. 22, 2001, as amended at 71 FR 67779, Nov. 22, 2006; 75 FR 60251, Sept...

33 CFR 403.6 - Additional information. [Rule 6

Code of Federal Regulations, 2010 CFR

2010-07-01

..., DEPARTMENT OF TRANSPORTATION RULES OF PROCEDURE OF THE JOINT TOLLS REVIEW BOARD § 403.6 Additional.... [Rule 6] [24 FR 9307, Nov. 18, 1959; 24 FR 10445, Dec. 23, 1959. Redesignated at 47 FR 13805, Apr. 1...

76 FR 27660 - Endangered Species; Marine Mammals; Issuance of Permits

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-12

...; March 9, April 21, 2011. Society dba 2011. Brookfield Zoo. 24269A Chelonian Research 75 FR 62139.... Survey, Alaska 10, 2011. Science Center. 19806A Thomas Postel......... 75 FR 78731; December May 6, 2011...

7 CFR 301.45-3 - Generally infested areas.

Code of Federal Regulations, 2012 CFR

2012-01-01

... county. Brooke County. The entire county. Calhoun County. The entire county. Doddridge County. The entire..., Apr. 28, 2006; 71 FR 53547, Sept. 12, 2006; 71 FR 66830, Nov. 17, 2006; 74 FR 48002, Sept. 21, 2009...

76 FR 72505 - Proposed Collection; Comment Request for Form 2290/SP/FR

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2011-11-23

... Form 2290/SP/FR Heavy Highway Vehicle Use Tax Return. DATES: Written comments should be received on or... . SUPPLEMENTARY INFORMATION: Title: Heavy Highway Vehicle Use Tax Return. OMB Number: 1545-0143. Abstract: Form...

47 CFR 64.611 - Internet-based TRS registration.

Code of Federal Regulations, 2013 CFR

2013-10-01

... obligations under paragraphs (a), (c), (d), and (e) of this section using the Neutral Video Communication Service Platform. [73 FR 41295, July 18, 2008, as amended at 76 FR 59557, Sept. 27, 2011; 78 FR 40608...

48 CFR 225.1103 - Other provisions and clauses.

Code of Federal Regulations, 2011 CFR

2011-10-01

...-7007, Prohibition on Acquisition of United States Munitions List Items from Communist Chinese Military... Munitions List. [68 FR 16526, Mar. 31, 2003, as amended at 71 FR 39006, July 11, 2006; 71 FR 53046, Sept. 8...

48 CFR 225.1103 - Other provisions and clauses.

Code of Federal Regulations, 2012 CFR

2012-10-01

...-7007, Prohibition on Acquisition of United States Munitions List Items from Communist Chinese Military... Munitions List. [68 FR 16526, Mar. 31, 2003, as amended at 71 FR 39006, July 11, 2006; 71 FR 53046, Sept. 8...

A viable logarithmic f(R) model for inflation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Amin, M.; Khalil, S.; Salah, M.

2016-08-18

Inflation in the framework of f(R) modified gravity is revisited. We study the conditions that f(R) should satisfy in order to lead to a viable inflationary model in the original form and in the Einstein frame. Based on these criteria we propose a new logarithmic model as a potential candidate for f(R) theories aiming to describe inflation consistent with observations from Planck satellite (2015). The model predicts scalar spectral index 0.9615

16 CFR 801.15 - Aggregation of voting securities and assets the acquisition of which was exempt.

Code of Federal Regulations, 2011 CFR

2011-01-01

...) Sections 7A(c) (1), (5), (6), (7), (8), and (11)(B); (2) Sections 802.1, 802.2, 802.5, 802.6(b)(1), 802.8... that the acquisition price was in excess of $50 million (as adjusted). In the most recent year, sales... amended at 52 FR 7081, Mar. 6, 1987; 61 FR 13684, Mar. 28, 1996; 66 FR 8689, Feb. 1, 2001; 67 FR 11902...

40 CFR 52.2420 - Identification of plan.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Reference conditions 6/24/09 4/25/11, 76 FR 22814 Revised section. 5-30-30 Sulfur Oxides (Sulfur Dioxide) 5... D. 5-30-40 Carbon Monoxide 9/8/04 3/3/06, 71 FR 10842 5-30-50 Ozone (1-hour) 9/8/04 3/3/06, 71 FR... Particulate Matter (AQCR 7) 4/17/95 4/21/00, 65 FR 21315 120-04-0404. 5-40-280 Standard for Sulfur Dioxide 4...

40 CFR 52.2420 - Identification of plan.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Reference conditions 6/24/09 4/25/11, 76 FR 22814 Revised section. 5-30-30 Sulfur Oxides (Sulfur Dioxide) 5... D. 5-30-40 Carbon Monoxide 9/8/04 3/3/06, 71 FR 10842 5-30-50 Ozone (1-hour) 9/8/04 3/3/06, 71 FR... Particulate Matter (AQCR 7) 4/17/95 4/21/00, 65 FR 21315 120-04-0404. 5-40-280 Standard for Sulfur Dioxide 4...

Episodic sucrose intake during food restriction increases synaptic abundance of AMPA receptors in nucleus accumbens and augments intake of sucrose following restoration of ad libitum feeding.

PubMed

Peng, X-X; Lister, A; Rabinowitsch, A; Kolaric, R; Cabeza de Vaca, S; Ziff, E B; Carr, K D

2015-06-04

Weight-loss dieting often leads to loss of control, rebound weight gain, and is a risk factor for binge pathology. Based on findings that food restriction (FR) upregulates sucrose-induced trafficking of glutamatergic AMPA receptors to the nucleus accumbens (NAc) postsynaptic density (PSD), this study was an initial test of the hypothesis that episodic "breakthrough" intake of forbidden food during dieting interacts with upregulated mechanisms of synaptic plasticity to increase reward-driven feeding. Ad libitum (AL) fed and FR subjects consumed a limited amount of 10% sucrose, or had access to water, every other day for 10 occasions. Beginning three weeks after return of FR rats to AL feeding, when 24-h chow intake and rate of body weight gain had normalized, subjects with a history of sucrose intake during FR consumed more sucrose during a four week intermittent access protocol than the two AL groups and the group that had access to water during FR. In an experiment that substituted noncontingent administration of d-amphetamine for sucrose, FR subjects displayed an enhanced locomotor response during active FR but a blunted response, relative to AL subjects, during recovery from FR. This result suggests that the enduring increase in sucrose consumption is unlikely to be explained by residual enhancing effects of FR on dopamine signaling. In a biochemical experiment which paralleled the sucrose behavioral experiment, rats with a history of sucrose intake during FR displayed increased abundance of pSer845-GluA1, GluA2, and GluA3 in the NAc PSD relative to rats with a history of FR without sucrose access and rats that had been AL throughout, whether they had a history of episodic sucrose intake or not. A history of FR, with or without a history of sucrose intake, was associated with increased abundance of GluA1. A terminal 15-min bout of sucrose intake produced a further increase in pSer845-GluA1 and GluA2 in subjects with a history of sucrose intake during FR. Generally, neither a history of sucrose intake nor a terminal bout of sucrose intake affected AMPA receptor abundance in the NAc PSD of AL subjects. Together, these results are consistent with the hypothesis, but the functional contribution of increased synaptic incorporation of AMPA receptors remains to be established. Copyright © 2015 IBRO. Published by Elsevier Ltd. All rights reserved.

Removing interictal fast ripples on electrocorticography linked with seizure freedom in children.

PubMed

Wu, J Y; Sankar, R; Lerner, J T; Matsumoto, J H; Vinters, H V; Mathern, G W

2010-11-09

Fast ripples (FR, 250-500 Hz) detected with chronic intracranial electrodes are proposed biomarkers of epileptogenesis. This study determined whether resection of FR-containing neocortex recorded during intraoperative electrocorticography (ECoG) was associated with postoperative seizure freedom in pediatric patients with mostly extratemporal lesions. FRs were retrospectively reviewed in 30 consecutive pediatric cases. ECoGs were recorded at 2,000 Hz sampling rate and visually inspected for FR, with reviewer blinded to the resection and outcome. Average age at surgery was 9.1 ± 6.7 years, ECoG duration was 11.8 ± 8.1 minutes, and postoperative follow-up was 27 ± 4 months. FRs were undetected in 6 ECoGs with remote or extensive lesions. FR episodes (n = 273) were identified in ECoGs from 24 patients, and in 64% FRs were independent of spikes, sharp waves, voltage attenuation, and paroxysmal fast activity. Of these 24 children, FR-containing cortex was removed in 19 and all became seizure-free, including 1 child after a second surgery. The remaining 5 children had incomplete FR resection and all continued with seizures postoperatively. In 2 ECoGs, the location of electrographic seizures matched FR location. FR-containing cortex was found outside of MRI and FDG-PET abnormalities in 6 children. FRs were detected during intraoperative ECoG in 80% of pediatric epilepsy cases, and complete resection of FR cortex correlated with postoperative seizure freedom. These findings support the view that interictal FRs are excellent surrogate markers of epileptogenesis, can be recorded during brief ECoG, and could be used to guide future surgical resections in children.

Behavioral economic analysis of water intake in a laboratory rhesus macaque.

PubMed

Wakita, Masumi

2004-10-01

Behavioral economics is useful for understanding the influence of environmental manipulation on a variety of behaviors, including drug self-administration, food intake, and stock behavior. The present study employed behavioral economics to investigate the psychologically satisfying amount of water intake in a laboratory rhesus macaque. Our institutional guidelines set a minimum amount of daily water intake. However, no study to date has determined whether that minimum amount is psychologically sufficient. In the present experiment, a monkey lived in an individual cage in which the only water available was delivered by chain pulling. A fixed number of responses was required for water delivery. This fixed ratio (FR) of responses per water delivery was progressively increased from FR 2 to FR 10. The study findings showed that during the FR 2 condition, demand for water was saturated at 131.3 ml/kg body weight (BW) (ranging from 95.1 to 211.2). The monkey's daily intake of water decreased as FR size incrementally increased, approaching an asymptote under the FR 8 and FR 10 conditions. During the FR 8 and FR 10 conditions, responding ceased when this monkey earned 53.5 ml/kg-BW (ranging from 32.7 to 74.9) of water. Therefore, the amount of water obtained under these conditions might provide a psychologically satisfying amount. Although these values were obtained from the behavioral study of one monkey, they were almost equivalent to values in our institutional guidelines that were determined by veterinary observations. These findings imply that behavioral economics is useful for studying the welfare of laboratory animals.

AGN jet power, formation of X-ray cavities, and FR I/II dichotomy in galaxy clusters

NASA Astrophysics Data System (ADS)

Fujita, Yutaka; Kawakatu, Nozomu; Shlosman, Isaac

2016-04-01

We investigate the ability of jets in active galactic nuclei to break out of the ambient gas with sufficiently large advance velocities. Using observationally estimated jet power, we analyze 28 bright elliptical galaxies in nearby galaxy clusters. Because the gas density profiles in the innermost regions of galaxies have not been resolved so far, we consider two extreme cases for temperature and density profiles. We also follow two types of evolution for the jet cocoons: being driven by the pressure inside the cocoon [Fanaroff-Riley (FR) type I], and being driven by the jet momentum (FR type II). Our main result is that regardless of the assumed form of the density profiles, jets with observed powers of ≲1044 erg s-1 are not powerful enough to evolve as FR II sources. Instead, they evolve as FR I sources and appear to be decelerated below the buoyant velocities of the cocoons when jets were propagating through the central dense regions of the host galaxies. This explains why FR I sources are more frequent than FR II sources in clusters. Furthermore, we predict the sizes of X-ray cavities from the observed jet powers and compare them with the observed ones-they are consistent within a factor of two if the FR I type evolution is realized. Finally, we find that the jets with a power ≳1044 erg s-1 are less affected by the ambient medium, and some of them, but not all, could serve as precursors of the FR II sources.

78 FR 31417 - National Priorities List, Final Rule No. 56

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-24

..., 1445 Ross Avenue, Suite 1200, Mailcode 6SFTS, Dallas, TX 75202-2733; 214/ 665-7436. Michelle Quick... Federal Register (48 FR 40674, September 8, 1983 and 53 FR 23988, June 24, 1988). The EPA is adding the...

47 CFR 0.601 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... this subpart each item on the agenda of a meeting is considered a meeting or a portion of a meeting. [42 FR 12867, Mar. 7, 1977, as amended at 48 FR 56391, Dec. 21, 1983; 64 FR 2149, Jan. 13, 1999] ...

47 CFR 0.601 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... this subpart each item on the agenda of a meeting is considered a meeting or a portion of a meeting. [42 FR 12867, Mar. 7, 1977, as amended at 48 FR 56391, Dec. 21, 1983; 64 FR 2149, Jan. 13, 1999] ...

47 CFR 0.601 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... this subpart each item on the agenda of a meeting is considered a meeting or a portion of a meeting. [42 FR 12867, Mar. 7, 1977, as amended at 48 FR 56391, Dec. 21, 1983; 64 FR 2149, Jan. 13, 1999] ...

47 CFR 0.601 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... this subpart each item on the agenda of a meeting is considered a meeting or a portion of a meeting. [42 FR 12867, Mar. 7, 1977, as amended at 48 FR 56391, Dec. 21, 1983; 64 FR 2149, Jan. 13, 1999] ...

47 CFR 0.601 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... this subpart each item on the agenda of a meeting is considered a meeting or a portion of a meeting. [42 FR 12867, Mar. 7, 1977, as amended at 48 FR 56391, Dec. 21, 1983; 64 FR 2149, Jan. 13, 1999] ...

40 CFR 85.2231 - On-board diagnostic test equipment requirements.

Code of Federal Regulations, 2010 CFR

2010-07-01

.../code_of_federal_regulations/ibr_locations.html. (b) The test system shall be capable of communicating..._locations.html. (d) [Reserved] [61 FR 40948, Aug. 6, 1996, as amended at 63 FR 24434, May 4, 1998; 66 FR...

16 CFR 1211.2 - Definition.

Code of Federal Regulations, 2010 CFR

2010-01-01

... incorporation by reference was approved by the Director of the Federal Register in accordance with 5 U.S.C. 552..._regulations/ibr_locations.html. [57 FR 60455, Dec. 21, 1992, as amended at 62 FR 46667, Sept. 4, 1997; 65 FR...

48 CFR 3.502-2 - Subcontractor kickbacks.

Code of Federal Regulations, 2014 CFR

2014-10-01

.... 8703(b)). [52 FR 6121, Feb. 27, 1987; 52 FR 9989, Mar. 27, 1987, as amended at 53 FR 34226, Sept. 2... contract price charged by a prime contractor to the United States. (b) Imposes criminal penalties on any...

14 CFR 135.149 - Equipment requirements: General.

Code of Federal Regulations, 2010 CFR

2010-01-01

.... 135-1, 44 FR 26737, May 7, 1979; Amdt. 135-34, 54 FR 43926, Oct. 27, 1989; Amdt. 135-38, 55 FR 43310... REQUIREMENTS: COMMUTER AND ON DEMAND OPERATIONS AND RULES GOVERNING PERSONS ON BOARD SUCH AIRCRAFT Aircraft and...

14 CFR 135.149 - Equipment requirements: General.

Code of Federal Regulations, 2014 CFR

2014-01-01

.... 135-1, 44 FR 26737, May 7, 1979; Amdt. 135-34, 54 FR 43926, Oct. 27, 1989; Amdt. 135-38, 55 FR 43310... REQUIREMENTS: COMMUTER AND ON DEMAND OPERATIONS AND RULES GOVERNING PERSONS ON BOARD SUCH AIRCRAFT Aircraft and...

14 CFR 135.149 - Equipment requirements: General.

Code of Federal Regulations, 2013 CFR

2013-01-01

.... 135-1, 44 FR 26737, May 7, 1979; Amdt. 135-34, 54 FR 43926, Oct. 27, 1989; Amdt. 135-38, 55 FR 43310... REQUIREMENTS: COMMUTER AND ON DEMAND OPERATIONS AND RULES GOVERNING PERSONS ON BOARD SUCH AIRCRAFT Aircraft and...

14 CFR 135.149 - Equipment requirements: General.

Code of Federal Regulations, 2012 CFR

2012-01-01

.... 135-1, 44 FR 26737, May 7, 1979; Amdt. 135-34, 54 FR 43926, Oct. 27, 1989; Amdt. 135-38, 55 FR 43310... REQUIREMENTS: COMMUTER AND ON DEMAND OPERATIONS AND RULES GOVERNING PERSONS ON BOARD SUCH AIRCRAFT Aircraft and...

14 CFR 135.149 - Equipment requirements: General.

Code of Federal Regulations, 2011 CFR

2011-01-01

.... 135-1, 44 FR 26737, May 7, 1979; Amdt. 135-34, 54 FR 43926, Oct. 27, 1989; Amdt. 135-38, 55 FR 43310... REQUIREMENTS: COMMUTER AND ON DEMAND OPERATIONS AND RULES GOVERNING PERSONS ON BOARD SUCH AIRCRAFT Aircraft and...

40 CFR 52.786 - Inspection and maintenance program.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 38, Jan. 2, 1981; 51 FR 40677, Nov. 7, 1986; 55 FR 31052, July 31, 1990; 58 FR 62535, Nov. 29, 1993] ..., commitment to timely adopt and implement enhanced inspection and maintenance (I/M) rules for Lake and Porter...

76 FR 34252 - Notice Pursuant to the National Cooperative Research and Production Act of 1993; Portland Cement...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-13

...; Argos USA Corporation, Houston, TX; Penta Engineering Corporation, St. Louis, MO; and Schreiber Yonley... March 7, 2011 (76 FR 12370). Patricia A. Brink, Director of Civil Enforcement, Antitrust Division. [FR...

78 FR 51058 - Airworthiness Directives; Airbus Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-20

... below the center wing box between frame (FR) 40 and FR 42, and in part of the area of the upper... NDT inspections for cracks in the affected areas of the keel beam side panel below the center wing box...

49 CFR 570.9 - Tires.

Code of Federal Regulations, 2012 CFR

2012-10-01

... shall not be exposed, either to the naked eye or when cuts or abrasions on the tire are probed. (1... probe cuts or abrasions. [38 FR 23950, Sept. 5, 1973, as amended at 39 FR 12868, Apr. 9, 1974; 39 FR...

49 CFR 570.9 - Tires.

Code of Federal Regulations, 2014 CFR

2014-10-01

... shall not be exposed, either to the naked eye or when cuts or abrasions on the tire are probed. (1... probe cuts or abrasions. [38 FR 23950, Sept. 5, 1973, as amended at 39 FR 12868, Apr. 9, 1974; 39 FR...

49 CFR 570.9 - Tires.

Code of Federal Regulations, 2011 CFR

2011-10-01

... shall not be exposed, either to the naked eye or when cuts or abrasions on the tire are probed. (1... probe cuts or abrasions. [38 FR 23950, Sept. 5, 1973, as amended at 39 FR 12868, Apr. 9, 1974; 39 FR...

49 CFR 570.9 - Tires.

Code of Federal Regulations, 2010 CFR

2010-10-01

... shall not be exposed, either to the naked eye or when cuts or abrasions on the tire are probed. (1... probe cuts or abrasions. [38 FR 23950, Sept. 5, 1973, as amended at 39 FR 12868, Apr. 9, 1974; 39 FR...

49 CFR 570.9 - Tires.

Code of Federal Regulations, 2013 CFR

2013-10-01

... shall not be exposed, either to the naked eye or when cuts or abrasions on the tire are probed. (1... probe cuts or abrasions. [38 FR 23950, Sept. 5, 1973, as amended at 39 FR 12868, Apr. 9, 1974; 39 FR...

47 CFR 90.5 - Other applicable rule parts.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Offices. (b) Part 1 includes rules of practice and procedure for the filing of applications for stations... microwave services. [43 FR 54791, Nov. 22, 1978, as amended at 50 FR 39677, Sept. 30, 1985; 55 FR 20398, May...

31 CFR 341.10 - Reissue.

Code of Federal Regulations, 2012 CFR

2012-07-01

... the case of a bond registered in beneficiary form upon the owner's request on Form PD 3564. No consent..., Parkersburg, WV 26101. [28 FR 405, Jan 16, 1963, as amended at 42 FR 21611, Apr. 28, 1977; 42 FR 57123, Nov. 1...

31 CFR 341.10 - Reissue.

Code of Federal Regulations, 2010 CFR

2010-07-01

... the case of a bond registered in beneficiary form upon the owner's request on Form PD 3564. No consent..., Parkersburg, WV 26101. [28 FR 405, Jan 16, 1963, as amended at 42 FR 21611, Apr. 28, 1977; 42 FR 57123, Nov. 1...

31 CFR 341.10 - Reissue.

Code of Federal Regulations, 2011 CFR

2011-07-01

... the case of a bond registered in beneficiary form upon the owner's request on Form PD 3564. No consent..., Parkersburg, WV 26101. [28 FR 405, Jan 16, 1963, as amended at 42 FR 21611, Apr. 28, 1977; 42 FR 57123, Nov. 1...

47 CFR 74.751 - Modification of transmission systems.

Code of Federal Regulations, 2013 CFR

2013-10-01

...: Video Division, Media Bureau, is notified in writing upon the completion of such changes. (d) Upon..., Nov. 1, 1974; 45 FR 26067, Apr. 17, 1980; 47 FR 21501, May 18, 1982; 48 FR 41423, Sept. 15, 1983; 50...

47 CFR 74.751 - Modification of transmission systems.

Code of Federal Regulations, 2010 CFR

2010-10-01

...: Video Division, Media Bureau, is notified in writing upon the completion of such changes. (d) Upon..., Nov. 1, 1974; 45 FR 26067, Apr. 17, 1980; 47 FR 21501, May 18, 1982; 48 FR 41423, Sept. 15, 1983; 50...

47 CFR 74.751 - Modification of transmission systems.

Code of Federal Regulations, 2012 CFR

2012-10-01

...: Video Division, Media Bureau, is notified in writing upon the completion of such changes. (d) Upon..., Nov. 1, 1974; 45 FR 26067, Apr. 17, 1980; 47 FR 21501, May 18, 1982; 48 FR 41423, Sept. 15, 1983; 50...

47 CFR 74.751 - Modification of transmission systems.

Code of Federal Regulations, 2011 CFR

2011-10-01

...: Video Division, Media Bureau, is notified in writing upon the completion of such changes. (d) Upon..., Nov. 1, 1974; 45 FR 26067, Apr. 17, 1980; 47 FR 21501, May 18, 1982; 48 FR 41423, Sept. 15, 1983; 50...

47 CFR 74.751 - Modification of transmission systems.

Code of Federal Regulations, 2014 CFR

2014-10-01

...: Video Division, Media Bureau, is notified in writing upon the completion of such changes. (d) Upon..., Nov. 1, 1974; 45 FR 26067, Apr. 17, 1980; 47 FR 21501, May 18, 1982; 48 FR 41423, Sept. 15, 1983; 50...

29 CFR 4.55 - Issuance and revision of wage determinations.

Code of Federal Regulations, 2010 CFR

2010-07-01

... for all bidders so none will be placed at a competitive disadvantage. (c) Determinations issued by the... competitive disadvantage. [48 FR 49762, Oct. 27, 1983. Redesignated at 61 FR 68664, Dec. 30, 1996; 70 FR 50898...

40 CFR 52.1070 - Identification of plan.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Revised .14B(1). 26.11.06.15 Nitrogen Oxides from Nitric Acid Plants 8/1/88 11/3/92, 57 FR 49651 (c)(90)(i... Requirements 12/17/07 6/11/13; 78 FR 34911 26.11.34.07 Initial NMOG Credit Account Balances 12/17/07 6/11/13... Credit Account Balances 12/17/07 6/11/13; 78 FR 34911 26.11.34.11 Vehicle Testing 12/17/07 6/11/13; 78 FR...

40 CFR 52.570 - Identification of plan.

Code of Federal Regulations, 2013 CFR

2013-07-01

...) Incinerators 6/15/98 12/2/99, 64 FR 67491 391-3-1-.02(2)(d) Fuel-burning Equipment 7/20/05 2/9/09, 75 FR 6309... Concrete Hot Mix Plants 1/17/79 9/18/79, 44 FR 54047 391-3-1-.02(2)(l) Conical Burners 1/17/79 9/18/79, 44... Emissions from Fuel-burning Equipment 2/16/00 7/10/01, 66 FR 35906 391-3-1-.02(2)(mmm) NOX Emissions from...

Visual and semi-automatic non-invasive detection of interictal fast ripples: A potential biomarker of epilepsy in children with tuberous sclerosis complex.

PubMed

Bernardo, Danilo; Nariai, Hiroki; Hussain, Shaun A; Sankar, Raman; Salamon, Noriko; Krueger, Darcy A; Sahin, Mustafa; Northrup, Hope; Bebin, E Martina; Wu, Joyce Y

2018-04-03

We aim to establish that interictal fast ripples (FR; 250-500 Hz) are detectable on scalp EEG, and to investigate their association to epilepsy. Scalp EEG recordings of a subset of children with tuberous sclerosis complex (TSC)-associated epilepsy from two large multicenter observational TSC studies were analyzed and compared to control children without epilepsy or any other brain-based diagnoses. FR were identified both by human visual review and compared with semi-automated review utilizing a deep learning-based FR detector. Seven out of 7 children with TSC-associated epilepsy had scalp FR compared to 0 out of 4 children in the control group (p = 0.003). The automatic detector has a sensitivity of 98% and false positive rate with average of 11.2 false positives per minute. Non-invasive detection of interictal scalp FR was feasible, by both visual and semi-automatic detection. Interictal scalp FR occurred exclusively in children with TSC-associated epilepsy and were absent in controls without epilepsy. The proposed detector achieves high sensitivity of FR detection; however, expert review of the results to reduce false positives is advised. Interictal FR are detectable on scalp EEG and may potentially serve as a biomarker of epilepsy in children with TSC. Copyright © 2018 International Federation of Clinical Neurophysiology. All rights reserved.

Folate receptor {alpha} regulates cell proliferation in mouse gonadotroph {alpha}T3-1 cells

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yao, Congjun; Evans, Chheng-Orn; Stevens, Victoria L.

We have previously found that the mRNA and protein levels of the folate receptor alpha (FR{alpha}) are uniquely over-expressed in clinically human nonfunctional (NF) pituitary adenomas, but the mechanistic role of FR{alpha} has not fully been determined. We investigated the effect of FR{alpha} over-expression in the mouse gonadotroph {alpha}T3-1 cell line as a model for NF pituitary adenomas. We found that the expression and function of FR{alpha} were strongly up-regulated, by Western blotting and folic acid binding assay. Furthermore, we found a higher cell growth rate, an enhanced percentage of cells in S-phase by BrdU assay, and a higher PCNAmore » staining. These observations indicate that over-expression of FR{alpha} promotes cell proliferation. These effects were abrogated in the same {alpha}T3-1 cells when transfected with a mutant FR{alpha} cDNA that confers a dominant-negative phenotype by inhibiting folic acid binding. Finally, by real-time quantitative PCR, we found that mRNA expression of NOTCH3 was up-regulated in FR{alpha} over-expressing cells. In summary, our data suggests that FR{alpha} regulates pituitary tumor cell proliferation and mechanistically may involve the NOTCH pathway. Potentially, this finding could be exploited to develop new, innovative molecular targeted treatment for human NF pituitary adenomas.« less

38 CFR 3.160 - Status of claims.

Code of Federal Regulations, 2010 CFR

2010-07-01

..., whichever is the earlier. (See §§ 20.1103 and 20.1104 of this chapter.) (e) Reopened claim. Any application..., as amended at 31 FR 12056, Sept. 15, 1966; 55 FR 20148, May 15, 1990; 58 FR 32445, June 10, 1993] ...

75 FR 34108 - National Grid USA; Notice of Filing

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-16

.... 707, 73 FR 11013 (Feb. 29, 2008), FERC Stats. & Regs. ] 31,264, at P 4-5, order on rehearing, Order No. 707-A, 73 FR 43072 (Jul. 24, 2008), FERC Stats. & Regs. ] 31,272 (2008). Any person desiring to...

40 CFR 61.01 - Lists of pollutants and applicability of part 61.

Code of Federal Regulations, 2010 CFR

2010-07-01

...) Chromium (50 FR 24317; June 10, 1985) Copper (52 FR 5496; Feb. 23, 1987) Epichlorohydrin (50 FR 24575; June... stationary sources by an authorized State air pollution control agency or by the Administrator of the U.S...

40 CFR 61.01 - Lists of pollutants and applicability of part 61.

Code of Federal Regulations, 2011 CFR

2011-07-01

...) Chromium (50 FR 24317; June 10, 1985) Copper (52 FR 5496; Feb. 23, 1987) Epichlorohydrin (50 FR 24575; June... stationary sources by an authorized State air pollution control agency or by the Administrator of the U.S...

77 FR 12056 - Agency Information Collection Activities: Announcement of Board Approval Under Delegated...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-28

... proposed to the FR 2644; however, going forward, the Federal Reserve will modify the FR 2644 instructions... agreement corporations. Data from this reporting form comprise a piece of the flow of funds data that are...

77 FR 73676 - Notice Pursuant to the National Cooperative Research and Production Act of 1993; National...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-11

..., Morgan Hill, CA; and Waltonen Engineering, Inc., Warren, MI, have been added as parties to this venture... September 5, 2012 (77 FR 54611). Patricia A. Brink, Director of Civil Enforcement, Antitrust Division. [FR...

49 CFR 192.63 - Marking of materials.

Code of Federal Regulations, 2011 CFR

2011-10-01

... thermoplastic fittings must be marked in accordance with ASTM D2513-87 (incorporated by reference, see § 192.7.... 9, 1989; 58 FR 14521, Mar. 18, 1993; Amdt. 192-76, 61 FR 26122, May 24, 1996; 61 FR 36826, July 15...

77 FR 46114 - Notice of Intent To Repatriate Cultural Items: Peabody Museum of Archaeology and Ethnology...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-02

... Repatriate (NIR) published in the Federal Register (73 FR 58619-58620, October 7, 2008), which itself corrected an earlier NIR published in the Federal Register (72 FR 41522-41524, July 30, 2007). After...

47 CFR 80.271 - Technical requirements for portable survival craft radiotelephone transceivers.

Code of Federal Regulations, 2011 CFR

2011-10-01

...:9 with no significant adverse effect upon the performance of the device; (5) The transceivers must... Commission's database. [51 FR 31213, Sept. 2, 1986, as amended at 63 FR 36607, July 7, 1998; 73 FR 4483, Jan...

47 CFR 74.731 - Purpose and permissible service.

Code of Federal Regulations, 2011 CFR

2011-10-01

... of a video and audio feed, in which case modulating equipment meeting the requirements of § 74.750(d..., Jan. 13, 1978; 47 FR 21499, May 18, 1982; 47 FR 40172, Sept. 13, 1982; 48 FR 21487, May 12, 1983; 52...

47 CFR 74.731 - Purpose and permissible service.

Code of Federal Regulations, 2010 CFR

2010-10-01

... of a video and audio feed, in which case modulating equipment meeting the requirements of § 74.750(d..., as amended at 43 FR 1951, Jan. 13, 1978; 47 FR 21499, May 18, 1982; 47 FR 40172, Sept. 13, 1982; 48...

47 CFR 73.1560 - Operating power and mode tolerances.

Code of Federal Regulations, 2010 CFR

2010-10-01

...: Audio Division (radio) or Video Division (television), Media Bureau, not later than the 10th day of the.... [44 FR 58734, Oct. 11, 1979, as amended at 49 FR 22093, May 25, 1984; 49 FR 29069, July 18, 1984; 49...

47 CFR 74.731 - Purpose and permissible service.

Code of Federal Regulations, 2013 CFR

2013-10-01

... of a video and audio feed, in which case modulating equipment meeting the requirements of § 74.750(d..., Jan. 13, 1978; 47 FR 21499, May 18, 1982; 47 FR 40172, Sept. 13, 1982; 48 FR 21487, May 12, 1983; 52...

47 CFR 73.1560 - Operating power and mode tolerances.

Code of Federal Regulations, 2012 CFR

2012-10-01

...: Audio Division (radio) or Video Division (television), Media Bureau, not later than the 10th day of the.... [44 FR 58734, Oct. 11, 1979, as amended at 49 FR 22093, May 25, 1984; 49 FR 29069, July 18, 1984; 49...

47 CFR 74.731 - Purpose and permissible service.

Code of Federal Regulations, 2012 CFR

2012-10-01

... of a video and audio feed, in which case modulating equipment meeting the requirements of § 74.750(d..., Jan. 13, 1978; 47 FR 21499, May 18, 1982; 47 FR 40172, Sept. 13, 1982; 48 FR 21487, May 12, 1983; 52...

47 CFR 73.1560 - Operating power and mode tolerances.

Code of Federal Regulations, 2011 CFR

2011-10-01

...: Audio Division (radio) or Video Division (television), Media Bureau, not later than the 10th day of the.... [44 FR 58734, Oct. 11, 1979, as amended at 49 FR 22093, May 25, 1984; 49 FR 29069, July 18, 1984; 49...

47 CFR 73.1560 - Operating power and mode tolerances.

Code of Federal Regulations, 2013 CFR

2013-10-01

...: Audio Division (radio) or Video Division (television), Media Bureau, not later than the 10th day of the.... [44 FR 58734, Oct. 11, 1979, as amended at 49 FR 22093, May 25, 1984; 49 FR 29069, July 18, 1984; 49...

47 CFR 74.731 - Purpose and permissible service.

Code of Federal Regulations, 2014 CFR

2014-10-01

... of a video and audio feed, in which case modulating equipment meeting the requirements of § 74.750(d..., Jan. 13, 1978; 47 FR 21499, May 18, 1982; 47 FR 40172, Sept. 13, 1982; 48 FR 21487, May 12, 1983; 52...

47 CFR 73.1560 - Operating power and mode tolerances.

Code of Federal Regulations, 2014 CFR

2014-10-01

...: Audio Division (radio) or Video Division (television), Media Bureau, not later than the 10th day of the.... [44 FR 58734, Oct. 11, 1979, as amended at 49 FR 22093, May 25, 1984; 49 FR 29069, July 18, 1984; 49...

Exposure to lower red to far-red light ratios improve tomato tolerance to salt stress.

PubMed

Cao, Kai; Yu, Jie; Xu, Dawei; Ai, Kaiqi; Bao, Encai; Zou, Zhirong

2018-05-24

Red (R) and far-red (FR) light distinctly influence phytochrome-mediated initial tomato growth and development, and more recent evidence indicates that these spectra also modulate responses to a multitude of abiotic and biotic stresses. This research investigated whether different R: FR values affect tomato growth response and salinity tolerance. Tomato seedlings were exposed to different R: FR conditions (7.4, 1.2 and 0.8) under salinity stress (100 mM NaCl), and evaluated for their growth, biochemical changes, active reactive oxygen species (ROS) and ROS scavenging enzymes, pigments, rate of photosynthesis, and chlorophyll fluorescence. The results showed that under conditions of salinity, tomato seedlings subjected to a lower R: FR value (0.8) significantly increased both their growth, proline content, chlorophyll content and net photosynthesis rate (Pn), while they decreased malondialdehyde (MDA) compared to the higher R: FR value (7.4). Under conditions of salinity, the lower R: FR value caused a decrease in both the superoxide anion (O 2 •- ) and in hydrogen peroxide (H 2 O 2 ) generation, an increase in the activities of superoxidase dismutase (SOD, EC 1.15.1.1), peroxidase (POD, EC 1.11.1.7) and catalase (CAT, EC 1.11.1.7). Tomato seedlings grown under the lower R: FR value and conditions of salinity showed a higher actual quantum yield of photosynthesis (ΦPSII), electron transport rate (ETR), and photochemical quenching (qP) than those exposed to a higher R: FR, indicating overall healthier growth. However, the salinity tolerance induced at the lower R: FR condition disappeared in the tomato phyB1 mutant. These results suggest that growing tomato with a lower R: FR value could improve seedlings' salinity tolerance, and phytochrome B1 play an very important role in this process. Therefore, different qualities of light can be used to efficiently develop abiotic stress tolerance in tomato cultivation.

Precursors of developmental dyslexia: an overview of the longitudinal Dutch Dyslexia Programme study.

PubMed

van der Leij, Aryan; van Bergen, Elsje; van Zuijen, Titia; de Jong, Peter; Maurits, Natasha; Maassen, Ben

2013-11-01

Converging evidence suggests that developmental dyslexia is a neurobiological disorder, characterized by deficits in the auditory, visual, and linguistic domains. In the longitudinal project of the Dutch Dyslexia Programme, 180 children with a familial risk of dyslexia (FR) and a comparison group of 120 children without FR (noFR) were followed from the age of 2 months up to 9 years. Children were assessed on (1) auditory, speech, and visual event-related potentials every half year between 2 and 41 months; (2) expressive and receptive language, motor development, behaviour problems, and home-literacy environment by questionnaires at the age of 2 and 3; (3) speech-language and cognitive development from 47 months onwards; and (4) preliteracy and subskills of reading, and reading development during kindergarten and Grades 2 and 3. With regard to precursors of reading disability, first analyses showed specific differences between FR and noFR children in neurophysiological, cognitive, and early language measures. Once reading tests administered from age 7 to 9 years were available, the children were divided into three groups: FR children with and without dyslexia, and controls. Analyses of the differences between reading groups yielded distinct profiles and developmental trajectories. On early speech and visual processing, and several cognitive measures, performance of the non-dyslexic FR group differed from the dyslexic FR group and controls, indicating continuity of the influence of familial risk. Parental reading and rapid naming skills appeared to indicate their offspring's degree of familial risk. Furthermore, on rapid naming and nonverbal IQ, the non-dyslexic FR group performed similarly to the controls, suggesting protective factors. There are indications of differences between the FR and control groups, irrespective of reading outcome. These results contribute to the distinction between the deficits correlated to dyslexia as a manifest reading disorder and deficits correlated to familial risk only. Copyright © 2013 John Wiley & Sons, Ltd.

76 FR 59990 - Endangered and Threatened Wildlife and Plants; Revised Endangered Status, Revised Critical...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-28

...), concerning the Service's delisting of the Northern Rocky Mountain gray wolf (74 FR 15123, Apr. 12, 2009); and... Service's 2008 finding on a petition to list the Gunnison's prairie dog (73 FR 6660, Feb. 5, 2008). The...

78 FR 61348 - Electricity Advisory Committee

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-03

... DEPARTMENT OF ENERGY Electricity Advisory Committee AGENCY: Department of Energy. ACTION: Notice of Cancellation of Open Meeting. SUMMARY: On September 11, 2013, in FR Doc. 2013-22119, on pages... October 2-3, 2013 of the Electricity Advisory Committee (78 FR 55692). This notice announces the...

40 CFR 52.1820 - Identification of plan.

Code of Federal Regulations, 2012 CFR

2012-07-01

.../98, 63 FR 45722 33-15-01-14 Time schedule for compliance 10/1/87 5/12/89, 54 FR 20574 33-15-01-15... 4/6/12, 77 FR 20894 American Crystal Sugar at Drayton SIP Chapter 8, Section 8.3, Continuous...

48 CFR 212.7002-1 - Contracts under the program.

Code of Federal Regulations, 2013 CFR

2013-10-01

... item or process that does not meet the definition of “commercial item,” if the contract— (1) Is awarded... computer software. [69 FR 63330, Nov. 1, 2004, as amended at 71 FR 18669, Apr. 12, 2006; 73 FR 21845, Apr...

48 CFR 212.7002-1 - Contracts under the program.

Code of Federal Regulations, 2014 CFR

2014-10-01

... item or process that does not meet the definition of “commercial item,” if the contract— (1) Is awarded... computer software. [69 FR 63330, Nov. 1, 2004, as amended at 71 FR 18669, Apr. 12, 2006; 73 FR 21845, Apr...

48 CFR 212.7002-1 - Contracts under the program.

Code of Federal Regulations, 2011 CFR

2011-10-01

... item or process that does not meet the definition of “commercial item,” if the contract— (1) Is awarded... computer software. [69 FR 63330, Nov. 1, 2004, as amended at 71 FR 18669, Apr. 12, 2006; 73 FR 21845, Apr...

48 CFR 212.7002-1 - Contracts under the program.

Code of Federal Regulations, 2012 CFR

2012-10-01

... item or process that does not meet the definition of “commercial item,” if the contract— (1) Is awarded... computer software. [69 FR 63330, Nov. 1, 2004, as amended at 71 FR 18669, Apr. 12, 2006; 73 FR 21845, Apr...

76 FR 50881 - Required Scale Tests

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-17

... RIN 0580-AB10 Required Scale Tests AGENCY: Grain Inspection, Packers and Stockyards Administration... required scale tests. Those documents defined ``limited seasonal basis'' incorrectly. This document... 20, 2011 (76 FR 3485) and on April 4, 2011 (76 FR 18348), concerning required scale tests. Those...

47 CFR 73.1010 - Cross reference to rules in other parts.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Auxiliary Stations”; (5) Subpart G, “Low Power TV, TV Translator and TV Booster Stations”; (6) Subpart H... Booster Stations”. [53 FR 2498, Jan. 28, 1988, as amended at 57 FR 48333, Oct. 23, 1992; 60 FR 55480, Nov...

47 CFR 73.1010 - Cross reference to rules in other parts.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Auxiliary Stations”; (5) Subpart G, “Low Power TV, TV Translator and TV Booster Stations”; (6) Subpart H... Booster Stations”. [53 FR 2498, Jan. 28, 1988, as amended at 57 FR 48333, Oct. 23, 1992; 60 FR 55480, Nov...

47 CFR 73.1010 - Cross reference to rules in other parts.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Auxiliary Stations”; (5) Subpart G, “Low Power TV, TV Translator and TV Booster Stations”; (6) Subpart H... Booster Stations”. [53 FR 2498, Jan. 28, 1988, as amended at 57 FR 48333, Oct. 23, 1992; 60 FR 55480, Nov...

47 CFR 73.1010 - Cross reference to rules in other parts.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Auxiliary Stations”; (5) Subpart G, “Low Power TV, TV Translator and TV Booster Stations”; (6) Subpart H... Booster Stations”. [53 FR 2498, Jan. 28, 1988, as amended at 57 FR 48333, Oct. 23, 1992; 60 FR 55480, Nov...

47 CFR 73.1010 - Cross reference to rules in other parts.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Auxiliary Stations”; (5) Subpart G, “Low Power TV, TV Translator and TV Booster Stations”; (6) Subpart H... Booster Stations”. [53 FR 2498, Jan. 28, 1988, as amended at 57 FR 48333, Oct. 23, 1992; 60 FR 55480, Nov...

21 CFR 1.231 - How and where do you register?

Code of Federal Regulations, 2014 CFR

2014-04-01

... writing to the U.S. Food and Drug Administration (HFS-681), 5600 Fishers Lane, Rockville, MD 20857 or by... (Roman) alphabet. [68 FR 58960, Oct. 10, 2003, as amended at 69 FR 29428, May 24, 2004; 73 FR 15883, Mar...

21 CFR 1.231 - How and where do you register?

Code of Federal Regulations, 2013 CFR

2013-04-01

... writing to the U.S. Food and Drug Administration (HFS-681), 5600 Fishers Lane, Rockville, MD 20857 or by... (Roman) alphabet. [68 FR 58960, Oct. 10, 2003, as amended at 69 FR 29428, May 24, 2004; 73 FR 15883, Mar...

21 CFR 1.231 - How and where do you register?

Code of Federal Regulations, 2012 CFR

2012-04-01

... writing to the U.S. Food and Drug Administration (HFS-681), 5600 Fishers Lane, Rockville, MD 20857 or by... (Roman) alphabet. [68 FR 58960, Oct. 10, 2003, as amended at 69 FR 29428, May 24, 2004; 73 FR 15883, Mar...

21 CFR 1.231 - How and where do you register?

Code of Federal Regulations, 2010 CFR

2010-04-01

... writing to the U.S. Food and Drug Administration (HFS-681), 5600 Fishers Lane, Rockville, MD 20857 or by... (Roman) alphabet. [68 FR 58960, Oct. 10, 2003, as amended at 69 FR 29428, May 24, 2004; 73 FR 15883, Mar...

21 CFR 1.231 - How and where do you register?

Code of Federal Regulations, 2011 CFR

2011-04-01

... writing to the U.S. Food and Drug Administration (HFS-681), 5600 Fishers Lane, Rockville, MD 20857 or by... (Roman) alphabet. [68 FR 58960, Oct. 10, 2003, as amended at 69 FR 29428, May 24, 2004; 73 FR 15883, Mar...

30 CFR 735.15 - Amount of grants.

Code of Federal Regulations, 2010 CFR

2010-07-01

..., 501, 503, 705, Pub. L. 95-87, 91 Stat. 450, 467, 470, 520 (30 U.S.C. 1211, 1251, 1253, 1295)) [42 FR 62706, Dec. 13, 1977. Redesignated at 44 FR 15312, Mar. 13, 1979, and amended at 45 FR 2804, Jan. 14...

78 FR 54454 - Open Meeting of the Information Security and Privacy Advisory Board

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-04

... include the following items: --Cybersecurity Executive Order 13636, Improving Critical Infrastructure Cybersecurity (78 FR 11737, February 19, 2013); Development of New Cybersecurity Framework; Request for Information (RFI)--Developing a Framework to Improve Critical Infrastructure Cybersecurity (78 FR 13024...

75 FR 33166 - Extension of Expiration Dates for Several Body System Listings

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-11

... Impairment, Hematological Disorders, Musculoskeletal System, Mental Disorders, Neurological, and Respiratory... be effective: Growth Impairment (100.00); Respiratory System (3.00 and 103.00); Hematological... listings (70 FR 53323 (2005)), the respiratory listings (70 FR 19358 (2005)), the cardiovascular listings...

47 CFR 76.952 - Information to be provided by cable operator on monthly subscriber bills.

Code of Federal Regulations, 2010 CFR

2010-10-01

... and phone number of the franchising authority, unless the franchising authority in writing requests... system. [58 FR 29753, May 21, 1993, as amended at 59 FR 17960, Apr. 15, 1994; 64 FR 35950, July 2, 1999] ...

78 FR 21183 - Persons on Whom Sanctions Have Been Imposed Under the Iran Sanctions Act of 1996 and the Iran...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-09

...: On general issues: Office of Sanctions Policy and Implementation, Department of State, Telephone... FR 56866, September 14, 2011) --Petro[acute]leos de Venezuela S.A. (see Public Notice 7585, 76 FR...

Military Uniforms: Issues Related to the Supply of Flame Resistant Fibers for the Production of Military Uniforms

DTIC Science & Technology

2011-06-30

fibers. A variety of fibers may be used to create a fabric blend, including FR rayon, Nomex®, Twaron®, Kevlar®, FR cotton, polybenzimidazole ( PBI ...as meta-aramids (e.g., Nomex®), modacrylic, PBI , and FR-treated cotton. o For example, the Army is currently testing fabrics in an attempt to...considering fabric blends containing FR-treated cotton as a potential alternative. o The Marine Corps uses PBI fibers in its balaclava (a protective

Wormhole solutions in f(R) gravity satisfying energy conditions

NASA Astrophysics Data System (ADS)

Mazharimousavi, S. Habib; Halilsoy, M.

2016-10-01

Without reference to exotic sources construction of viable wormholes in Einstein’s general relativity remained ever a myth. With the advent of modified theories, however, specifically the f(R) theory, new hopes arose for the possibility of such objects. From this token, we construct traversable wormholes in f(R) theory supported by a fluid source which respects at least the weak energy conditions. We provide an example (Example 1) of asymptotically flat wormhole in f(R) gravity without ghosts.

Fructose liquid and solid formulations differently affect gut integrity, microbiota composition and related liver toxicity: a comparative in vivo study.

PubMed

Mastrocola, Raffaella; Ferrocino, Ilario; Liberto, Erica; Chiazza, Fausto; Cento, Alessia Sofia; Collotta, Debora; Querio, Giulia; Nigro, Debora; Bitonto, Valeria; Cutrin, Juan Carlos; Rantsiou, Kalliopi; Durante, Mariaconcetta; Masini, Emanuela; Aragno, Manuela; Cordero, Chiara; Cocolin, Luca; Collino, Massimo

2018-05-01

Despite clinical findings suggesting that the form (liquid versus solid) of the sugars may significantly affect the development of metabolic diseases, no experimental data are available on the impact of their formulations on gut microbiota, integrity and hepatic outcomes. In the present sudy, C57Bl/6j mice were fed a standard diet plus water (SD), a standard diet plus 60% fructose syrup (L-Fr) or a 60% fructose solid diet plus water (S-Fr) for 12 weeks. Gut microbiota was characterized through 16S rRNA phylogenetic profiling and shotgun sequencing of microbial genes in ileum content and related volatilome profiling. Fructose feeding led to alterations of the gut microbiota depending on the fructose formulation, with increased colonization by Clostridium, Oscillospira and Clostridiales phyla in the S-Fr group and Bacteroides, Lactobacillus, Lachnospiraceae and Dorea in the L-Fr. S-Fr evoked the highest accumulation of advanced glycation end products and barrier injury in the ileum intestinal mucosa. These effects were associated to a stronger activation of the lipopolysaccharide-dependent proinflammatory TLR4/NLRP3 inflammasome pathway in the liver of S-Fr mice than of L-Fr mice. In contrast, L-Fr intake induced higher levels of hepatosteatosis and markers of fibrosis than S-Fr. Fructose-induced ex novo lipogenesis with production of SCFA and MCFA was confirmed by metagenomic analysis. These results suggest that consumption of fructose under different forms, liquid or solid, may differently affect gut microbiota, thus leading to impairment in intestinal mucosa integrity and liver homeostasis. Copyright © 2018 Elsevier Inc. All rights reserved.

Fructose-fed streptozotocin-injected rat: an alternative model for type 2 diabetes.

PubMed

Wilson, Rachel D; Islam, Md Shahidul

2012-01-01

The main objective of the study was to develop an alternative non-genetic rat model for type 2 diabetes (T2D). Six-week-old male Sprague-Dawley rats (190.56 ± 23.60 g) were randomly divided into six groups, namely: Normal Control (NC), Diabetic Control (DBC), Fructose-10 (FR10), Fructose-20 (FR20), Fructose-30 (FR30) and Fructose-40 (FR40) and were fed a normal rat pellet diet ad libitum for 2 weeks. During this period, the two control groups received normal drinking water whilst the fructose groups received 10, 20, 30 and 40% fructose in drinking water ad libitum, respectively. After two weeks of dietary manipulation, all groups except the NC group received a single injection (i.p.) of streptozotocin (STZ) (40 mg/kg b.w.) dissolved in citrate buffer (pH 4.4). The NC group received only a vehicle buffer injection (i.p.). One week after the STZ injection, animals with non-fasting blood glucose levels > 300 mg/dl were considered as diabetic. Three weeks after the STZ injection, the animals in FR20, FR30 and FR40 groups were eliminated from the study due to the severity of diabetes and the FR10 group was selected for the remainder of the 11 weeks experimental period. The significantly (p < 0.05) higher fluid intake, blood glucose, serum lipids, liver glycogen, liver function enzymes and insulin resistance (HOMA-IR) and significantly (p < 0.05) lower body weight, oral glucose tolerance, number of pancreatic β-cells and pancreatic β-cell functions (HOMA-β) of FR10 group demonstrate that the 10% fructose-fed followed by 40 mg/kg of BWSTZ injected rat can be a new and alternative model for T2D.

Folate receptor-mediated boron-10 containing carbon nanoparticles as potential delivery vehicles for boron neutron capture therapy of nonfunctional pituitary adenomas.

PubMed

Dai, Congxin; Cai, Feng; Hwang, Kuo Chu; Zhou, Yongmao; Zhang, Zizhu; Liu, Xiaohai; Ma, Sihai; Yang, Yakun; Yao, Yong; Feng, Ming; Bao, Xinjie; Li, Guilin; Wei, Junji; Jiao, Yonghui; Wei, Zhenqing; Ma, Wenbin; Wang, Renzhi

2013-02-01

Invasive nonfunctional pituitary adenomas (NFPAs) are difficult to completely resect and often develop tumor recurrence after initial surgery. Currently, no medications are clinically effective in the control of NFPA. Although radiation therapy and radiosurgery are useful to prevent tumor regrowth, they are frequently withheld because of severe complications. Boron neutron capture therapy (BNCT) is a binary radiotherapy that selectively and maximally damages tumor cells without harming the surrounding normal tissue. Folate receptor (FR)-targeted boron-10 containing carbon nanoparticles is a novel boron delivery agent that can be selectively taken up by FR-expressing cells via FR-mediated endocytosis. In this study, FR-targeted boron-10 containing carbon nanoparticles were selectively taken up by NFPAs cells expressing FR but not other types of non-FR expressing pituitary adenomas. After incubation with boron-10 containing carbon nanoparticles and following irradiation with thermal neutrons, the cell viability of NFPAs was significantly decreased, while apoptotic cells were simultaneously increased. However, cells administered the same dose of FR-targeted boron-10 containing carbon nanoparticles without neutron irradiation or received the same neutron irradiation alone did not show significant decrease in cell viability or increase in apoptotic cells. The expression of Bcl-2 was down-regulated and the expression of Bax was up-regulated in NFPAs after treatment with FR-mediated BNCT. In conclusion, FR-targeted boron-10 containing carbon nanoparticles may be an ideal delivery system of boron to NFPAs cells for BNCT. Furthermore, our study also provides a novel insight into therapeutic strategies for invasive NFPA refractory to conventional therapy, while exploring these new applications of BNCT for tumors, especially benign tumors.

A Comparison Study of an Active Region Eruptive Filament and a Neighboring Non-Eruptive Filament

NASA Astrophysics Data System (ADS)

Wu, S. T.; Jiang, C.; Feng, X. S.; Hu, Q.

2014-12-01

We perform a comparison study of an eruptive filament in the core region of AR 11283 and a nearby non-eruptive filament. The coronal magnetic field supporting these two filaments is extrapolated using our data-driven CESE-MHD-NLFFF code (Jiang et al. 2013, Jiang etal. 2014), which presents two magnetic flux ropes (FRs) in the same extrapolation box. The eruptive FR contains a bald-patch separatrix surface (BPSS) spatially co-aligned very well with a pre-eruption EUV sigmoid, which is consistent with the BPSS model for the coronal sigmoids. The numerically reproduced magnetic dips of the FRs match observations of the filaments strikingly well, which supports strongly the FR-dip model for filaments. The FR that supports the AR eruptive filament is much smaller (with a length of 3 Mm) compared with the large-scale FR holding the quiescent filament (with a length of 30 Mm). But the AR eruptive FR contains most of the magnetic free energy in the extrapolation box and holds a much higher magnetic energy density than the quiescent FR, because it resides along the main polarity inversion line (PIL) around sunspots with strong magnetic shear. Both the FRs are weakly twisted and cannot trigger kink instability. The AR eruptive FR is unstable because its axis reaches above a critical height for torus instability (TI), at which the overlying closed arcades can no longer confine the FR stably. To the contrary, the quiescent FR is firmly held down by its overlying field, as its axis apex is far below the TI threshold height. (This work is partially supported by NSF AGS-1153323 and 1062050)

NR2A- and NR2B-NMDA receptors and drebrin within postsynaptic spines of the hippocampus correlate with hunger-evoked exercise.

PubMed

Chen, Yi-Wen; Actor-Engel, Hannah; Sherpa, Ang Doma; Klingensmith, Lauren; Chowdhury, Tara G; Aoki, Chiye

2017-07-01

Hunger evokes foraging. This innate response can be quantified as voluntary wheel running following food restriction (FR). Paradoxically, imposing severe FR evokes voluntary FR, as some animals choose to run rather than eat, even during limited periods of food availability. This phenomenon, called activity-based anorexia (ABA), has been used to identify brain changes associated with FR and excessive exercise (EX), two core symptoms of anorexia nervosa (AN), and to explore neurobiological bases of AN vulnerability. Previously, we showed a strong positive correlation between suppression of FR-evoked hyperactivity, i.e., ABA resilience, and levels of extra-synaptic GABA receptors in stratum radiatum (SR) of hippocampal CA1. Here, we tested for the converse: whether animals with enhanced expression of NMDA receptors (NMDARs) exhibit greater levels of FR-evoked hyperactivity, i.e., ABA vulnerability. Four groups of animals were assessed for NMDAR levels at CA1 spines: (1) ABA, in which 4 days of FR was combined with wheel access to allow voluntary EX; (2) FR only; (3) EX only; and (4) control (CON) that experienced neither EX nor FR. Electron microscopy revealed that synaptic NR2A-NMDARs and NR2B-NMDARs levels are significantly elevated, relative to CONs'. Individuals' ABA severity, based on weight loss, correlated with synaptic NR2B-NMDAR levels. ABA resilience, quantified as suppression of hyperactivity, correlated strongly with reserve pools of NR2A-NMDARs in spine cytoplasm. NR2A- and NR2B-NMDAR measurements correlated with spinous prevalence of an F-actin binding protein, drebrin, suggesting that drebrin enables insertion of NR2B-NMDAR to and retention of NR2A-NMDARs away from synaptic membranes, together influencing ABA vulnerability.

Programmable fast-freezing method improves the post-thaw motion dynamics, integrities of plasmalemma, mitochondrial transmembrane, DNA and, acrosome, and in vivo fertility of water buffalo (Bubalus bubalis) spermatozoa.

PubMed

Khalil Ur Rehman, H; Andrabi, S M H; Ahmed, H; Shah, S A H

2017-10-01

The effects of freezing methods (FR1, nonprogrammable/static, 5 cm above liquid nitrogen [LN 2 ] for 10 min, plunging in LN 2 ; FR2, programmable medium, +4°C to -15°C at 3°C min -1 , from -15 to -80°C at 10°C min -1 and final holding for 1 min at -80°C, plunging in LN 2 ; FR3, programmable fast, from initial holding at +4°C for 2 min, from +4°C to -20°C at 10°C min -1 , from -20°C to -100°C at 30°C min -1 , final holding for 1 min at -100°C and plunging in LN 2 ) were assessed on post-thaw in vitro quality and in vivo fertility of water buffalo spermatozoa. Mean sperm progressive motility (%), rapid velocity (%), average path velocity (μm s -1 ), straight line velocity (μm s -1 ), curved line velocity (μm s -1 ), integrities (%) of plasmalemma, mitochondrial transmembrane, DNA and acrosome were higher (p < .05) in samples cryopreserved with FR3 compared to FR1 and FR2. Similarly, in vivo fertility (%) of buffalo spermatozoa was higher (p < .05) with FR3 than FR1 (%; 68.0 versus 50.0). We concluded that programmable fast-freezing method (FR3) improves the post-thaw in vitro quality and in vivo fertility of water buffalo spermatozoa. © 2016 Blackwell Verlag GmbH.

Quantifying the lumbar flexion-relaxation phenomenon: theory, normative data, and clinical applications.

PubMed

Neblett, Randy; Mayer, Tom G; Gatchel, Robert J; Keeley, Janice; Proctor, Tim; Anagnostis, Christopher

2003-07-01

A two-part investigation was conducted: 1) a prospective study of asymptomatic subjects quantitatively comparing trunk mobility to surface electromyographic (sEMG) signals from the erector spinae during trunk flexion; and 2) a prospective repeated-measures cohort study of patients with chronic disabled work-related spinal disorder tested for the flexion-relaxation (FR) phenomenon while measured simultaneously for lumbar spine inclinometric range of motion (ROM). To describe a theoretical model for the potential use of FR unloaded in assessing patients with chronic low back pain patients before and after rehabilitation, and to establish a normative database (Part 1) for subsequent use in comparison to patients with chronic low back pain (Part 2). The second part of the study assessed the clinical utility of combined sEMG and ROM measurements for assessing the FR phenomenon as a test to assist potentially in planning rehabilitation programs, guiding patients' individual rehabilitation progress, and identifying early posttreatment outcome failures. The FR phenomenon has been recognized since 1951, and it can be reproducibly assessed in normal subjects with FR unloaded. It can be found intermittently in patients with chronic low back pain. Recent studies have moved toward deriving formulas to identify FR, but only a few have examined a potential relation between inclinometric lumbar motion measures and the sEMG signal. No previous studies have developed normative data potentially useful for objectively assessing nonoperative treatment progress, effort, or the validity of permanent impairment rating measures. In Part 1, 12 asymptomatic subjects were evaluated in an intra- and interrater repeated-measures protocol to examine reliability of sEMG signal readings in FR, as well as ROM measures at FR and maximum voluntary flexion. The mean sEMG signal averaging right-left electrode recordings, as well as the gross, true, and sacral lumbar ROM measurements, were recorded as normative data. In Part 2, 54 patients with chronic disabled work-related spinal disorder referred as candidates for tertiary functional restoration rehabilitation participated in a standardized assessment protocol for sEMG and ROM measurement before rehabilitation. Those who completed the program were retested with the identical methodology after rehabilitation (n = 34) using the empirically derived cutoff scores for sEMG readings at FR and ROM from Part 1 and prior scientific literature. Pain disability self-reported scores were correlated with sEMG and ROM. Sensitivity and specificity of the sEMG for identifying abnormal motion were assessed. In Part 1, the ability of the experienced testers to measure ROM and sEMG reliably at FR was high (r >or= 0.92; P < 0.001). All asymptomatic subjects achieved FR at a tightly clustered range of mean sEMG signals from 1 to 2.3 microV. Most of the variation between motion at FR and maximum voluntary flexion occurred through the hip (sacral) motion component of the gross (or total) motion measured at T12. In Part 2, posttreatment reliability for ROM, sEMG, and the ability to detect the FR point was high (r >or= 0.82; P < 0.001). More than 30% of the 54 patients tested before treatment demonstrated ability to achieve FR, with FR usually associated with higher ROM than in the non-FR patients. After treatment, 94% of those who completed the program achieved FR, including all those who achieved FR before treatment. Flexion-relaxation was associated with major improvement in ROM and pain disability self-report. Flexion-relaxation measures a point at which true lumbar flexion ROM approaches its maximum in asymptomatic subjects. This also is the point at which lumbar extensor muscle contraction relaxes, allowing the lumbar spine to hang on its posterior ligaments. The gluteal and hamstring muscles then lower the flexed trunk even further by allowing the pelvis to rotate around the hips. This phenomenon was subsequently found in Part 2 to offer a potentially promising method for individualizing rehabilitation treatment, decreasing unnecessary utilization, identifying potential postrehabilitation treatment failures, and assessing permanent impairment rating validity. Moreover, this is the first study to demonstrate systematically that an absence of FR in patients with chronic low back pain can be corrected with treatment.

Effective Dark Matter Halo Catalog in f(R) Gravity.

PubMed

He, Jian-Hua; Hawken, Adam J; Li, Baojiu; Guzzo, Luigi

2015-08-14

We introduce the idea of an effective dark matter halo catalog in f(R) gravity, which is built using the effective density field. Using a suite of high resolution N-body simulations, we find that the dynamical properties of halos, such as the distribution of density, velocity dispersion, specific angular momentum and spin, in the effective catalog of f(R) gravity closely mimic those in the cold dark matter model with a cosmological constant (ΛCDM). Thus, when using effective halos, an f(R) model can be viewed as a ΛCDM model. This effective catalog therefore provides a convenient way for studying the baryonic physics, the galaxy halo occupation distribution and even semianalytical galaxy formation in f(R) cosmologies.

Development of Core Data Set of the Officer Longitudinal Research Data Base

DTIC Science & Technology

1987-07-01

FR EQ U EN CI ES FR OM TH E OM F. J DA TA OM FF RE Q; IN FI LE...OC FR EQ ; n ~ > t-3 ctJ ~ 10 q ts:l z n t< n 0 q z t-3 (/) 0 I’Jj ~ t-3 > ts:l t’i ts:l ~ ts:l z t-3 (/) 0 1󈧏 )I ’t1 ’U tz j z 0 H X 0... FR EQ U EN CI ES FR OM TH E SO M F. I DA TA SO M FF RE Q; IN FI LE IN ; IN PU T SS N IB 4. TY R $C H A R2

39 CFR 3001.43 - Public attendance at Commission meetings.

Code of Federal Regulations, 2013 CFR

2013-07-01

... required by paragraph (f)(1) of this section) of the discussion of any item on the agenda, or of any item... 25729, May 19, 1977; 58 FR 38976, July 21, 1993; 62 FR 45530, Aug. 28, 1997; 65 FR 6544, Feb. 10, 2000...

39 CFR 3001.43 - Public attendance at Commission meetings.

Code of Federal Regulations, 2011 CFR

2011-07-01

...) of this section) of the discussion of any item on the agenda, or of any item of the testimony of any... 13290, Mar. 10, 1977, as amended at 42 FR 25729, May 19, 1977; 58 FR 38976, July 21, 1993; 62 FR 45530...

39 CFR 3001.43 - Public attendance at Commission meetings.

Code of Federal Regulations, 2014 CFR

2014-07-01

... required by paragraph (f)(1) of this section) of the discussion of any item on the agenda, or of any item... 25729, May 19, 1977; 58 FR 38976, July 21, 1993; 62 FR 45530, Aug. 28, 1997; 65 FR 6544, Feb. 10, 2000...

39 CFR 3001.43 - Public attendance at Commission meetings.

Code of Federal Regulations, 2012 CFR

2012-07-01

...) of this section) of the discussion of any item on the agenda, or of any item of the testimony of any... 13290, Mar. 10, 1977, as amended at 42 FR 25729, May 19, 1977; 58 FR 38976, July 21, 1993; 62 FR 45530...

40 CFR 180.142 - 2,4-D; tolerances for residues.

Code of Federal Regulations, 2010 CFR

2010-07-01

..., group 5 0.4 Vegetable, bulb, group 3 0.05 Vegetable, cucurbit, group 9 0.05 Vegetable, foliage of legume..., legume, group 6 0.05 [72 FR 52017, Sept. 12, 2007, as amended at 73 FR 53737, Sept. 17, 2008; 74 FR 48411...

40 CFR 180.142 - 2,4-D; tolerances for residues.

Code of Federal Regulations, 2011 CFR

2011-07-01

..., group 5 0.4 Vegetable, bulb, group 3 0.05 Vegetable, cucurbit, group 9 0.05 Vegetable, foliage of legume..., legume, group 6 0.05 [72 FR 52017, Sept. 12, 2007, as amended at 73 FR 53737, Sept. 17, 2008; 74 FR 48411...

Use of chemosensitization to overcome fludioxonil resistance in Penicillium expansum

USDA-ARS?s Scientific Manuscript database

Penicillium expansum mutants (FR2 and FR3) resistant to fludioxonil, a phenylpyrrole fungicide, became susceptible through chemosensitization mediated by natural phenolics. Increased sensitivity of FR3 to oxidizing agents, compared to its parental strain (W2), indicated the oxidative stress respons...

28 CFR 0.105 - General functions.

Code of Federal Regulations, 2013 CFR

2013-07-01

... marshal as a peace officer, in particular those set forth in 28 U.S.C. 570 and 18 U.S.C. 3053: (1) While... 1176-87, 52 FR 11044, Apr. 7, 1987; Order 1237-87, 52 FR 44971, Nov. 24, 1987; Order 1245-87, 52 FR...

77 FR 1458 - Honey From Argentina: Preliminary Results of Antidumping Duty Administrative Review and Partial...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-10

...: Ninth Administrative Review of the Antidumping Duty Order on Certain Pasta from Italy, 71 FR 45017... Antidumping Duty Order on Certain Pasta from Italy, 72 FR 7011 (February 14, 2007)); see also 19 CFR 351.412(c...

77 FR 79 - Honey From the People's Republic of China: Preliminary Rescission of the Administrative Review

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-03

... of Antidumping Duty New Shipper Review of Hebei New Donghua Amino Acid Co., Ltd., 69 FR 47405, 47406... Shipper Review, 68 FR 1439, 1440 (January 10, 2003). \\14\\ See Hebei New Donghua Amino Acid Co., Ltd. v...

77 FR 38653 - Endangered Species; Marine Mammals; Issuance of Permits

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-28

.... 65782A, 65783A, 65785A, 65787A, Feld Entertainment, 77 FR 17494; March 26, May 14, 2012. 65789A, 65790A..., 65780A, and Feld Entertainment, 77 FR 17494; March 26, May 17, 2012. 65781A,. Inc.. 2012. 71576A U.S...

30 CFR 735.11 - Eligibility for program development grants.

Code of Federal Regulations, 2010 CFR

2010-07-01

..., 503, 705, Pub. L. 95-87, 91 Stat. 450, 467, 470, 520, (30 U.S.C. 1211, 1251, 1253, 1295)) [42 FR 62706, Dec. 13, 1977; 43 FR 2722, Jan. 19, 1977. Redesignated at 44 FR 15312, Mar. 13, 1979, and amended at...

75 FR 36358 - University of Maine System, et al.; Notice of Consolidated Decision on Applications for Duty-Free...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-25

.... Manufacturer: Japanese Electron-Optics, Limited (JEOL), Japan. Intended Use: See notice at 75 FR 29974, May 28...: Japanese Electron-Optics, Limited, (JEOL), Japan. Intended Use: See notice at 75 FR 29974, May 28, 2010...

77 FR 2972 - Thunder Bay Power Company, Thunder Bay Power, LLC, et al.

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-20

... Hydro, LLC. Dayton Fox River, LaSalle County, IL. P-2347-049 Midwest Hydro, Inc. Midwest Hydro, LLC... FR, Neenah Paper FR, Middle Appleton Dam Lower Fox River, LLC and N.E.W. LLC and N.E.W. Outagamie...

78 FR 25254 - Announcing an Open Meeting of the Information Security and Privacy Advisory Board

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-30

... include the following items: --Cybersecurity Executive Order 13636, Improving Critical Infrastructure Cybersecurity (78 FR 11737, February 19, 2013); Development of New Cybersecurity Framework; Request for Information (RFI)--Developing a Framework to Improve Critical Infrastructure Cybersecurity (78 FR 13024...

75 FR 71726 - Endangered and Threatened Wildlife and Plants; 5-Year Status Reviews of 58 Species in Washington...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-24

... Endangered U.S.A. (HI).... 56 FR 55770; 10/29/1991. arbuscula. Ma`o hau hele, (=native Hibiscus Endangered U.S.A. (HI).... 59 FR 56333; 11/10/1994. yellow hibiscus). brackenridgei. Aupaka Isodendrion...

Natural Rubber/Dendrimer Modified Montmorillonite Nanocomposites: Mechanical and Flame-Retardant Properties

PubMed Central

Zhang, Chenyang; Wang, Jincheng

2017-01-01

A series of flame-retardant nanocomposites were established based on compounding of natural rubber (NR) and dendrimer modified flame-retardant organic montmorillonite (FR-DOMt). The merits of these nanocomposites were focused on their better mechanical and flame-retardant properties. X-ray diffractometer (XRD) together with scanning electron microscopy (SEM) and transmission electron microscopy (TEM) analysis revealed that exfoliation, intercalation, or aggregation status in the NRmatrix can be achieved by addition of different amounts of FR-DOMt. The sound effects of blend ratio of FR-DOMt on mechanical, thermal stability, and flame-retardant (FR) properties of NR were studied. The NR/FR-DOMt-20 composite possessed the highest tensile strength, and this resulted from complicated interactions between layered silicates and elastomers. In addition, with loading of 20 phr of FR-DOMt, the flammability parameters of NR, such as heat release rate (HRR), smoke evolution area (SEA), and carbon monoxide (CO) concentration, were obviously reduced from cone calorimeter analysis. PMID:29283385

Neighbor detection at the leaf tip adaptively regulates upward leaf movement through spatial auxin dynamics

PubMed Central

Reinen, Emilie; Anten, Niels P. R.

2017-01-01

Vegetation stands have a heterogeneous distribution of light quality, including the red/far-red light ratio (R/FR) that informs plants about proximity of neighbors. Adequate responses to changes in R/FR are important for competitive success. How the detection and response to R/FR are spatially linked and how this spatial coordination between detection and response affects plant performance remains unresolved. We show in Arabidopsis thaliana and Brassica nigra that localized FR enrichment at the lamina tip induces upward leaf movement (hyponasty) from the petiole base. Using a combination of organ-level transcriptome analysis, molecular reporters, and physiology, we show that PIF-dependent spatial auxin dynamics are key to this remote response to localized FR enrichment. Using computational 3D modeling, we show that remote signaling of R/FR for hyponasty has an adaptive advantage over local signaling in the petiole, because it optimizes the timing of leaf movement in response to neighbors and prevents hyponasty caused by self-shading. PMID:28652357

Antioxidant activity and phenolic compositions of lentil (Lens culinaris var. Morton) extract and its fractions

PubMed Central

Zou, Yanping; Chang, Sam K.C.; Gu, Yan; Qian, Steven Y.

2011-01-01

Phenolic compounds were extracted from Morton lentils using acidified aqueous acetone. The crude Morton extract (CME) was applied onto a macroresin column and desorbed by aqueous methanol to obtain a semi-purified Morton extract (SPME). The SPME was further fractionated over Sephadex LH-20 column into five main fractions (Fr I – Fr V). The phytochemical contents such as total phenolic content (TPC), total flavonoid content (TFC), and condensed tannin content (CTC) of the CME, SPME, and its fractions were examined by colorimetric methods. Antioxidant activity of extracts and fractions were screened by DPPH scavenging activity, trolox equivalent antioxidant capacity (TEAC), ferric reduced antioxidant power (FRAP), and oxygen radical absorbing capacity (ORAC) methods. In addition, the compositions of active fractions were determined by HPLC-DAD and HPLC-MS methods. Results showed that fraction enriched in condensed tannins (Fr V) exhibited significantly higher value of TPC, CTC and higher antioxidant activity as compared to the crude extract, SPME and low-molecular-weight fractions (Fr I – IV). Eighteen compounds existed in those fractions, and seventeen were tentatively identified by UV and MS spectra. HPLC-MS analysis revealed Fr II contained mainly kaempferol glycoside, Fr III and Fr IV mainly contained flavonoid glycosides, and Fr V was composed of condensed tannins. The results suggested that extract of Morton lentils is a promising source of antioxidant phenolics, and may be used as a dietary supplement for health promotion. PMID:21332205

75 FR 18203 - Desert Southwest Power, LLC; Notice of Petition for Declaratory Order

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-09

... Reform, Order No. 679, 71 FR 43294 (July 31, 2006), FERC Stats. & Regs. ] 31,222 (2006), order on reh'g, Order No. 679-A, 72 FR 1152 (Jan. 10, 2007), FERC Stats. & Regs. ] 31,236 (2006), order on reh'g, 119...

5 CFR 2500.7 - Declassification and downgrading.

Code of Federal Regulations, 2011 CFR

2011-01-01

... INFORMATION SECURITY REGULATION § 2500.7 Declassification and downgrading. (a) Declassification authority. No... information. (b) Mandatory review for declassification. (1) Requests for mandatory review of national security... Information Security Regulation. [44 FR 50039, Aug. 27, 1979; 45 FR 20453, Mar. 28, 1980; 45 FR 22873, Apr. 4...

5 CFR 2500.7 - Declassification and downgrading.

Code of Federal Regulations, 2010 CFR

2010-01-01

... INFORMATION SECURITY REGULATION § 2500.7 Declassification and downgrading. (a) Declassification authority. No... information. (b) Mandatory review for declassification. (1) Requests for mandatory review of national security... Information Security Regulation. [44 FR 50039, Aug. 27, 1979; 45 FR 20453, Mar. 28, 1980; 45 FR 22873, Apr. 4...

75 FR 43502 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-26

... comments are received which result in a contrary determination. ADDRESSES: You may submit comments... (TFDW), (December 17, 2009; 74 FR 66961). M01080-2, U.S. Marine Corps Manpower Personnel Analysis... Corps Manpower Management Information System (MCMMIS), April 29, 2010, 75 FR 22570, therefore these...

78 FR 21841 - Approval and Promulgation of Implementation Plans; Region 4 States; Prong 3 Infrastructure...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-12

... July 18, 1997 (62 FR 38652), EPA promulgated a new annual PM 2.5 NAAQS and on October 17, 2006 (71 FR... WL 45653 (D.C. Cir., filed July 15, 2008) (consolidated with 09-1102, 11-1430), issued a judgment...

78 FR 72063 - Open Meeting of the Information Security and Privacy Advisory Board

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-02

... agenda is expected to include the following items: --Cybersecurity Executive Order 13636, Improving Critical Infrastructure Cybersecurity (78 FR 11737, February 19, 2013); Development of New Cybersecurity... Cybersecurity (78 FR 13024, February 26, 2013); Notice of Inquiry (NOI)--Incentives to Adopt Improved...

77 FR 32881 - Supervised Securities Holding Company Registration

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-04

...), The Report of Foreign Banking Organizations (FR Y-7), The Consolidated Financial Statements for Bank... Y-9ES), The Supplement to the Consolidated Financial Statements for Bank Holding Companies (FR Y-9CS... comprehensive consolidated supervision by a foreign regulator, a nonbank financial company supervised by the...

75 FR 49879 - Civil Penalties

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-16

... , including any personal information provided. Please see the Privacy Act heading below. Privacy Act: Anyone... pertaining to odometer tampering and disclosure requirements and vehicle theft prevention. 66 FR 41149. On... disclosure requirements. 75 FR 5246. We have reviewed the civil penalty amounts in 49 CFR part 578 and, in...

75 FR 76951 - Foreign-Trade Zone 86-Tacoma, WA Application for Reorganization Under Alternative Site Framework

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-10

... Order 216, 48 FR 34794, 08/01/83) and expanded on April 3, 1985 (Board Order 292, 50 FR 15206, 04/17/85... area under the ASF would be Pierce County, Washington, as described in the application. If approved...

Does nitrogen fertilization history affects short-term microbial responses and chemical properties of soils submitted to different glyphosate concentrations?

PubMed Central

Nivelle, Elodie; Chabot, Amélie; Roger, David; Spicher, Fabien; Lacoux, Jérôme; Nava-Saucedo, Jose-Edmundo; Catterou, Manuella; Tétu, Thierry

2017-01-01

The use of nitrogen (N) fertilizer and glyphosate-based herbicides is increasing worldwide, with agriculture holding the largest market share. The agronomic and socioeconomic utilities of glyphosate are well established; however, our knowledge of the potential effects of glyphosate applied in the presence or absence of long-term N fertilization on microbial functional activities and the availability of soil nutrients remains limited. Using an ex situ approach with soils that did (N+) or did not (N0) receive synthetic N fertilization for 6 years, we assessed the impact of different rates (no glyphosate, CK; field rate, FR; 100 × field rate, 100FR) of glyphosate application on biological and chemical parameters. We observed that, after immediate application (1 day), the highest dose of glyphosate (100FR) negatively affected the alkaline phosphatase (AlP) activity in soils without N fertilization history and decreased the cation exchange capacity (CEC) in N0 compared to CK and FR treatments with N+. Conversely, the 100FR application increased nitrate (NO3-) and available phosphorus (PO43-) regardless of N fertilization history. Then, after 8 and 15 days, the N+\\100FR and N+\\FR treatments exhibited the lowest values for dehydrogenase (DH) and AlP activities, respectively, while urease (URE) activity was mainly affected by N fertilization. After 15 days and irrespective of N fertilization history, the FR glyphosate application negatively affected the degradation of carbon substrates by microbial communities (expressed as the average well color development, AWCD). By contrast, the 100FR treatment positively affected AWCD, increasing PO43- by 5 and 16% and NO3- by 126 and 119% in the N+ and N0 treatments, respectively. In addition, the 100FR treatment resulted in an increase in the average net nitrification rate. Principal component analysis revealed that the 100FR glyphosate treatment selected microbial communities that were able to metabolize amine substrates. Overall, the lack of N fertilization in the 6 past years combined with the highest glyphosate application rate (100FR) induced the highest values of AWCD, functional diversity, NO3-, PO43- and nitrification. We concluded that the intensive use of N fertilization for 6 years may change the non-target effects of glyphosate application on enzyme activities. The functional activities, nitrification and nutrient contents were increased by glyphosate only when applied at 100 times the field application rate. PMID:28552945

Does nitrogen fertilization history affects short-term microbial responses and chemical properties of soils submitted to different glyphosate concentrations?

PubMed

Nivelle, Elodie; Verzeaux, Julien; Chabot, Amélie; Roger, David; Spicher, Fabien; Lacoux, Jérôme; Nava-Saucedo, Jose-Edmundo; Catterou, Manuella; Tétu, Thierry

2017-01-01

The use of nitrogen (N) fertilizer and glyphosate-based herbicides is increasing worldwide, with agriculture holding the largest market share. The agronomic and socioeconomic utilities of glyphosate are well established; however, our knowledge of the potential effects of glyphosate applied in the presence or absence of long-term N fertilization on microbial functional activities and the availability of soil nutrients remains limited. Using an ex situ approach with soils that did (N+) or did not (N0) receive synthetic N fertilization for 6 years, we assessed the impact of different rates (no glyphosate, CK; field rate, FR; 100 × field rate, 100FR) of glyphosate application on biological and chemical parameters. We observed that, after immediate application (1 day), the highest dose of glyphosate (100FR) negatively affected the alkaline phosphatase (AlP) activity in soils without N fertilization history and decreased the cation exchange capacity (CEC) in N0 compared to CK and FR treatments with N+. Conversely, the 100FR application increased nitrate (NO3-) and available phosphorus (PO43-) regardless of N fertilization history. Then, after 8 and 15 days, the N+\\100FR and N+\\FR treatments exhibited the lowest values for dehydrogenase (DH) and AlP activities, respectively, while urease (URE) activity was mainly affected by N fertilization. After 15 days and irrespective of N fertilization history, the FR glyphosate application negatively affected the degradation of carbon substrates by microbial communities (expressed as the average well color development, AWCD). By contrast, the 100FR treatment positively affected AWCD, increasing PO43- by 5 and 16% and NO3- by 126 and 119% in the N+ and N0 treatments, respectively. In addition, the 100FR treatment resulted in an increase in the average net nitrification rate. Principal component analysis revealed that the 100FR glyphosate treatment selected microbial communities that were able to metabolize amine substrates. Overall, the lack of N fertilization in the 6 past years combined with the highest glyphosate application rate (100FR) induced the highest values of AWCD, functional diversity, NO3-, PO43- and nitrification. We concluded that the intensive use of N fertilization for 6 years may change the non-target effects of glyphosate application on enzyme activities. The functional activities, nitrification and nutrient contents were increased by glyphosate only when applied at 100 times the field application rate.

77 FR 35747 - Highway Safety Programs; Conforming Products List of Evidential Breath Alcohol Measurement Devices

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-14

...-0061] Highway Safety Programs; Conforming Products List of Evidential Breath Alcohol Measurement... Evidential Breath Alcohol Measurement Devices dated, September 17, 1993 (58 FR 48705). DATES: Effective Date... Safety Administration (NHTSA) published the Standards for Devices to Measure Breath Alcohol (38 FR 30459...

47 CFR 64.607 - Furnishing related customer premises equipment.

Code of Federal Regulations, 2011 CFR

2011-10-01

.... 64.607 Section 64.607 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER... premises equipment. (a) Any communications common carrier may provide, under tariff, customer premises... computers. [56 FR 36731, Aug. 1, 1991, as amended at 72 FR 43560, Aug. 6, 2007; 73 FR 21252, Apr. 21, 2008...

47 CFR 64.607 - Furnishing related customer premises equipment.

Code of Federal Regulations, 2014 CFR

2014-10-01

.... 64.607 Section 64.607 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER... premises equipment. (a) Any communications common carrier may provide, under tariff, customer premises... computers. [56 FR 36731, Aug. 1, 1991, as amended at 72 FR 43560, Aug. 6, 2007; 73 FR 21252, Apr. 21, 2008...

47 CFR 64.607 - Furnishing related customer premises equipment.

Code of Federal Regulations, 2013 CFR

2013-10-01

.... 64.607 Section 64.607 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER... premises equipment. (a) Any communications common carrier may provide, under tariff, customer premises... computers. [56 FR 36731, Aug. 1, 1991, as amended at 72 FR 43560, Aug. 6, 2007; 73 FR 21252, Apr. 21, 2008...

47 CFR 64.607 - Furnishing related customer premises equipment.

Code of Federal Regulations, 2010 CFR

2010-10-01

.... 64.607 Section 64.607 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER... premises equipment. (a) Any communications common carrier may provide, under tariff, customer premises... computers. [56 FR 36731, Aug. 1, 1991, as amended at 72 FR 43560, Aug. 6, 2007; 73 FR 21252, Apr. 21, 2008...

47 CFR 64.607 - Furnishing related customer premises equipment.

Code of Federal Regulations, 2012 CFR

2012-10-01

.... 64.607 Section 64.607 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER... premises equipment. (a) Any communications common carrier may provide, under tariff, customer premises... computers. [56 FR 36731, Aug. 1, 1991, as amended at 72 FR 43560, Aug. 6, 2007; 73 FR 21252, Apr. 21, 2008...

75 FR 8377 - Privacy Act of 1974; Department of Homeland Security Immigration and Customs Enforcement-007...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-24

... Information Management System of Records AGENCY: Privacy Office, DHS. ACTION: Notice of modification to... Enforcement Support Center Alien Criminal Response Information Management System of Records (73 FR 74739... Enforcement Support Center (LESC) Alien Criminal Response Information Management (ACRIMe) System (73 FR 74739...

76 FR 4662 - Partial Grant of Clean Air Act Waiver Application Submitted by Growth Energy To Increase the...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-26

... docket. \\8\\ See 44 FR 12244 (February 23, 1979). \\9\\ See Waiver Decision on Application of E.I. DuPont de Nemours and Company (DuPont), 46 FR 6124 (February 28, 1983). For EPA to grant a waiver, the available...

78 FR 64204 - Science and Technology Reinvention Laboratory Personnel Management Demonstration Project...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-28

... Personnel Management Demonstration Project, Department of Navy, Office of Naval Research (ONR); Amendment... ONR Personnel Management Demonstration Project (75 FR 77380-77447, December 10, 2010). SUMMARY: On December 10, 2010 (75 FR 77380-77447), DoD published a notice of approval of a personnel management...

75 FR 82277 - Health Insurance Issuers Implementing Medical Loss Ratio (MLR) Requirements Under the Patient...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-30

...-AA06 Health Insurance Issuers Implementing Medical Loss Ratio (MLR) Requirements Under the Patient... Register (FR Doc 2010-29596 (75 FR 74864)) entitled ``Health Insurance Issuers Implementing Medical Loss... request for comments entitled ``Health Insurance Issuers Implementing Medical Loss Ratio (MLR...

48 CFR 13.501 - Special documentation requirements.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Special documentation... officer's knowledge and belief will serve as approval, unless a higher approval level is established in..., Sept. 30, 2005; 71 FR 57360, 57366, Sept. 28, 2006; 75 FR 34276, June 16, 2010; 75 FR 53132, Aug. 30...

18 CFR 382.102 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-04-01

... Southwestern Power Administration, and the Western Area Power Administration. [Order 472, 52 FR 21292, June 5, 1987, as amended by Order 472-B, 52 FR 36022, Sept. 25, 1987; Order 529, 55 FR 47321, Nov. 13, 1990... Natural Gas Act Section 7(f) declaration; and (4) Not holding a limited jurisdiction certificate. (b...

48 CFR 9.505-4 - Obtaining access to proprietary information.

Code of Federal Regulations, 2011 CFR

2011-10-01

..., the contractor may gain an unfair competitive advantage unless restrictions are imposed. These... connection with an acquisition, may give the contractor an unfair competitive advantage. Contractors should... competitive advantage. [48 FR 42142, Sept. 19, 1983, as amended at 55 FR 42686, Oct. 22, 1990; 56 FR 55377...

47 CFR 90.5 - Other applicable rule parts.

Code of Federal Regulations, 2012 CFR

2012-10-01

... governed under this part include the following: (a) Part 0 of the Commission's Rules describes the... obtaining equipment certification. (d) Part 5 contains standards and procedures for obtaining experimental... microwave services. [43 FR 54791, Nov. 22, 1978, as amended at 50 FR 39677, Sept. 30, 1985; 55 FR 20398, May...

47 CFR 90.5 - Other applicable rule parts.

Code of Federal Regulations, 2014 CFR

2014-10-01

... governed under this part include the following: (a) Part 0 of the Commission's Rules describes the... obtaining equipment certification. (d) Part 5 contains standards and procedures for obtaining experimental... microwave services. [43 FR 54791, Nov. 22, 1978, as amended at 50 FR 39677, Sept. 30, 1985; 55 FR 20398, May...

47 CFR 90.5 - Other applicable rule parts.

Code of Federal Regulations, 2013 CFR

2013-10-01

... governed under this part include the following: (a) Part 0 of the Commission's Rules describes the... obtaining equipment certification. (d) Part 5 contains standards and procedures for obtaining experimental... microwave services. [43 FR 54791, Nov. 22, 1978, as amended at 50 FR 39677, Sept. 30, 1985; 55 FR 20398, May...

17 CFR 275.203-1 - Application for investment adviser registration.

Code of Federal Regulations, 2010 CFR

2010-04-01

... must file electronically with the Investment Adviser Registration Depository (IARD), unless you have... you have paid the filing fee. [65 FR 57448, Sept. 22, 2000; 65 FR 81737, Dec. 27, 2000; 68 FR 42248... EXCHANGE COMMISSION (CONTINUED) RULES AND REGULATIONS, INVESTMENT ADVISERS ACT OF 1940 § 275.203-1...

78 FR 38450 - Agency Information Collection Activities; Information Collection Renewal; Reverse Mortgage...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-26

..., internal controls, and third party risk management. \\1\\ 74 FR 66652. \\2\\ 75 FR 50801. Prior to the... DEPARTMENT OF THE TREASURY Office of the Comptroller of the Currency FEDERAL DEPOSIT INSURANCE...: Office of the Comptroller of the Currency, Treasury (OCC); Federal Deposit Insurance Corporation (FDIC...

78 FR 45051 - Small Business Size Standards; Support Activities for Mining; Correction

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-26

... Federal Register on June 20, 2013 (78 FR 37404). The document amended SBA's Small Business Size... of Federal Regulations. DATES: Effective July 22, 2013. FOR FURTHER INFORMATION CONTACT: Khem Sharma..., DC 20416. SUPPLEMENTARY INFORMATION: In FR Doc. 2013-14712 appearing on page 37404 in the June 20...

78 FR 53733 - Procurement List Additions and Deletions

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-30

... INFORMATION CONTACT: Barry S. Lineback, Telephone: (703) 603-7740, Fax: (703) 603-0655, or email [email protected] . SUPPLEMENTARY INFORMATION: Additions On 7/8/2013 (78 FR 40727-40728) and 7/12/2013 (78 FR... military commissaries and exchanges as aggregated by the Defense Commissary Agency. Towel, Hazardous...

77 FR 32539 - Circular Welded Carbon-Quality Steel Pipe From the United Arab Emirates: Preliminary...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-01

... Investigations; Request for Comment, 73 FR 26371 (May 9, 2008). A. Targeted Dumping Test We conducted customer..., 2011, the Department initiated the antidumping duty investigations on certain steel pipe from India... the Socialist Republic of Vietnam: Initiation of Antidumping Duty Investigations, 76 FR 72164...

9 CFR 104.3 - Permit application.

Code of Federal Regulations, 2010 CFR

2010-01-01

... VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS PERMITS FOR BIOLOGICAL PRODUCTS § 104.3 Permit application. (a) Each person desiring to import a biological product shall make written... control number 0579-0013) [38 FR 32916, Nov. 29, 1973, as amended at 48 FR 57473, Dec. 30, 1983; 56 FR...

48 CFR 709.403 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Definitions. 709.403... official in USAID is the M/OAA Director. Suspending official in USAID is the M/OAA Director. [62 FR 40467, July 29, 1997, as amended at 64 FR 42040, Aug. 3, 1999; 72 FR 19670, Apr. 19, 2007] ...

48 CFR 709.403 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Definitions. 709.403... official in USAID is the M/OAA Director. Suspending official in USAID is the M/OAA Director. [62 FR 40467, July 29, 1997, as amended at 64 FR 42040, Aug. 3, 1999; 72 FR 19670, Apr. 19, 2007] ...

48 CFR 709.403 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Definitions. 709.403... official in USAID is the M/OAA Director. Suspending official in USAID is the M/OAA Director. [62 FR 40467, July 29, 1997, as amended at 64 FR 42040, Aug. 3, 1999; 72 FR 19670, Apr. 19, 2007] ...

48 CFR 709.403 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Definitions. 709.403... official in USAID is the M/OAA Director. Suspending official in USAID is the M/OAA Director. [62 FR 40467, July 29, 1997, as amended at 64 FR 42040, Aug. 3, 1999; 72 FR 19670, Apr. 19, 2007] ...

48 CFR 709.403 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Definitions. 709.403... official in USAID is the M/OAA Director. Suspending official in USAID is the M/OAA Director. [62 FR 40467, July 29, 1997, as amended at 64 FR 42040, Aug. 3, 1999; 72 FR 19670, Apr. 19, 2007] ...

77 FR 23159 - Locomotive Safety Standards; Correction

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-18

.... FRA-2009-0094 and FR-2009-0095, Notice No. 4] RIN 2130-AC16 Locomotive Safety Standards; Correction... notifying the public that the correct docket number for the Locomotive Safety Standards final rule is FRA... rule related to locomotive safety standards. See 77 FR 21312. The final rule established a public...

49 CFR 369.5 - Records.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 5 2010-10-01 2010-10-01 false Records. 369.5 Section 369.5 Transportation Other... TRANSPORTATION FEDERAL MOTOR CARRIER SAFETY REGULATIONS REPORTS OF MOTOR CARRIERS § 369.5 Records. Books, records... Records. [52 FR 10383, Apr. 1, 1987. Redesignated at 63 FR 52193, Sept. 30, 1998. Redesignated at 71 FR...

49 CFR 369.5 - Records.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 5 2011-10-01 2011-10-01 false Records. 369.5 Section 369.5 Transportation Other... TRANSPORTATION FEDERAL MOTOR CARRIER SAFETY REGULATIONS REPORTS OF MOTOR CARRIERS § 369.5 Records. Books, records... Records. [52 FR 10383, Apr. 1, 1987. Redesignated at 63 FR 52193, Sept. 30, 1998. Redesignated at 71 FR...

49 CFR 369.5 - Records.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 49 Transportation 5 2012-10-01 2012-10-01 false Records. 369.5 Section 369.5 Transportation Other... TRANSPORTATION FEDERAL MOTOR CARRIER SAFETY REGULATIONS REPORTS OF MOTOR CARRIERS § 369.5 Records. Books, records... Records. [52 FR 10383, Apr. 1, 1987. Redesignated at 63 FR 52193, Sept. 30, 1998. Redesignated at 71 FR...

49 CFR 369.5 - Records.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 5 2013-10-01 2013-10-01 false Records. 369.5 Section 369.5 Transportation Other... TRANSPORTATION FEDERAL MOTOR CARRIER SAFETY REGULATIONS REPORTS OF MOTOR CARRIERS § 369.5 Records. Books, records... Records. [52 FR 10383, Apr. 1, 1987. Redesignated at 63 FR 52193, Sept. 30, 1998. Redesignated at 71 FR...

76 FR 50223 - Statement of Organization, Functions, and Delegations of Authority

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-12

... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Statement of... Human Services (45 FR 67772-76, dated October 14, 1980, and corrected at 45 FR 69296, October 20, 1980...). (1) Provides leadership, management, and oversight for all division activities; (2) provides...

75 FR 80827 - Compliance Policy Guide; Radiofrequency Identification Feasibility Studies and Pilot Programs for...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-23

... Identification (RFID) Feasibility Studies and Pilot Programs for Drugs'' to December 31, 2012. FOR FURTHER... Sec. 400.210 entitled ``Radiofrequency Identification (RFID) Feasibility Studies and Pilot Programs... FR 65750, November 23, 2007; 73 FR 78371, December 22, 2008). FDA has identified RFID as a promising...

42 CFR 60.14 - The insurance premium.

Code of Federal Regulations, 2011 CFR

2011-10-01

... one-time special charge with no subsequent adjustments required. The lender may bill the borrower... premium through a notice published in the Federal Register. (c) Method of calculation—(1) Student... calculated for each disbursement. [48 FR 38988, Aug. 26, 1983, as amended at 51 FR 30644 Aug. 28, 1986; 52 FR...

42 CFR 60.14 - The insurance premium.

Code of Federal Regulations, 2014 CFR

2014-10-01

... one-time special charge with no subsequent adjustments required. The lender may bill the borrower... premium through a notice published in the Federal Register. (c) Method of calculation—(1) Student... calculated for each disbursement. [48 FR 38988, Aug. 26, 1983, as amended at 51 FR 30644 Aug. 28, 1986; 52 FR...

42 CFR 60.14 - The insurance premium.

Code of Federal Regulations, 2013 CFR

2013-10-01

... one-time special charge with no subsequent adjustments required. The lender may bill the borrower... premium through a notice published in the Federal Register. (c) Method of calculation—(1) Student... calculated for each disbursement. [48 FR 38988, Aug. 26, 1983, as amended at 51 FR 30644 Aug. 28, 1986; 52 FR...

42 CFR 60.14 - The insurance premium.

Code of Federal Regulations, 2012 CFR

2012-10-01

... one-time special charge with no subsequent adjustments required. The lender may bill the borrower... premium through a notice published in the Federal Register. (c) Method of calculation—(1) Student... calculated for each disbursement. [48 FR 38988, Aug. 26, 1983, as amended at 51 FR 30644 Aug. 28, 1986; 52 FR...

42 CFR 60.14 - The insurance premium.

Code of Federal Regulations, 2010 CFR

2010-10-01

... one-time special charge with no subsequent adjustments required. The lender may bill the borrower... premium through a notice published in the Federal Register. (c) Method of calculation—(1) Student... calculated for each disbursement. [48 FR 38988, Aug. 26, 1983, as amended at 51 FR 30644 Aug. 28, 1986; 52 FR...

75 FR 18208 - Agency Information Collection Activities: Announcement of Board Approval Under Delegated...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-09

... confidential treatment (5 U.S.C. 552(b)(4)). Abstract: This voluntary report collects derivatives market... ongoing triennial Survey of Foreign Exchange and Derivatives Market Activity (FR 3036; OMB No. 7100-0285... Derivatives Activity. Agency form number: FR 2436. OMB control number: 7100-0286. Frequency: Semiannually...

10 CFR 72.212 - Conditions of general license issued under § 72.210.

Code of Federal Regulations, 2011 CFR

2011-01-01

... as applied to a new protected area may be provided by a guard or watchman on patrol in lieu of video.... [55 FR 29191, July 18, 1990, as amended at 64 FR 53616, Oct. 4, 1999; 68 FR 54160, Sept. 16, 2003; 73...

10 CFR 72.212 - Conditions of general license issued under § 72.210.

Code of Federal Regulations, 2010 CFR

2010-01-01

... as applied to a new protected area may be provided by a guard or watchman on patrol in lieu of video.... [55 FR 29191, July 18, 1990, as amended at 64 FR 53616, Oct. 4, 1999; 68 FR 54160, Sept. 16, 2003; 73...

76 FR 28809 - Stainless Steel Plate From Belgium; Termination of Five-Year Review

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-18

... INTERNATIONAL TRADE COMMISSION [Investigation No. 701-TA-376 (Second Review)] Stainless Steel... countervailing duty order on stainless steel plate from Belgium (75 FR 30777 and 75 FR 30434). On May 5, 2011... countervailing duty order concerning stainless steel plate from Belgium, finding that revocation of the...

77 FR 61429 - Agency Information Collection Activities: Announcement of the Office of Management and Budget...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-09

... 1926.250). Cotton Dust (29 CFR 1910.1043) 10/05/2011, 76 FR 61752, Docket 1218-0061 03/31/2015 No. OSHA...-2011-0064. Grain Handling Facilities, (29 CFR 1910.272).. 02/22/2011, 76 FR 9815, Docket 1218-0206 08...

Clustering of galaxies with f(R) gravity

NASA Astrophysics Data System (ADS)

Capozziello, Salvatore; Faizal, Mir; Hameeda, Mir; Pourhassan, Behnam; Salzano, Vincenzo; Upadhyay, Sudhaker

2018-02-01

Based on thermodynamics, we discuss the galactic clustering of expanding Universe by assuming the gravitational interaction through the modified Newton's potential given by f(R) gravity. We compute the corrected N-particle partition function analytically. The corrected partition function leads to more exact equations of state of the system. By assuming that the system follows quasi-equilibrium, we derive the exact distribution function that exhibits the f(R) correction. Moreover, we evaluate the critical temperature and discuss the stability of the system. We observe the effects of correction of f(R) gravity on the power-law behaviour of particle-particle correlation function also. In order to check the feasibility of an f(R) gravity approach to the clustering of galaxies, we compare our results with an observational galaxy cluster catalogue.

Flame-retardant-wrapped polyphosphazene nanotubes: A novel strategy for enhancing the flame retardancy and smoke toxicity suppression of epoxy resins.

PubMed

Qiu, Shuilai; Wang, Xin; Yu, Bin; Feng, Xiaming; Mu, Xiaowei; Yuen, Richard K K; Hu, Yuan

2017-03-05

The structure of polyphosphazene nanotubes (PZS) is similar to that of carbon nanotubes (CNTs) before modification. For applications of CNTs in polymer composites, surface wrapping is an economically attractive route to achieve functionalized nanotubes. Based on this idea, functionalized polyphosphazene nanotubes (FR@PZS) wrapped with a cross-linked DOPO-based flame retardant (FR) were synthesized via one-step strategy and well characterized. Then, the obtained FR@PZS was introduced into epoxy resin (EP) to investigate flame retardancy and smoke toxicity suppression performance. Thermogravimetric analysis indicated that FR@PZS significantly enhanced the thermal stability of EP composites. Cone calorimeter results revealed that incorporation of FR@PZS obviously improved flame retardant performance of EP, for example, 46.0% decrease in peak heat release rate and 27.1% reduction in total heat release were observed in the case of epoxy composite with 3wt% FR@PZS. The evolution of toxic CO and other volatile products from the EP decomposition was significantly suppressed after the introduction of FR@PZS, Therefore, the smoke toxicity associates with burning EP was reduced. The presence of both PZS and a DOPO-based flame retardant was probably responsible for this substantial diminishment of fire hazard. Copyright © 2016 Elsevier B.V. All rights reserved.

Alternative Reinforcer Response Cost Impacts Cocaine Choice in Humans

PubMed Central

Stoops, William W.; Lile, Joshua A.; Glaser, Paul E.A.; Hays, Lon R.; Rush, Craig R.

2011-01-01

Cocaine use disorders are an unrelenting public health concern. Behavioral treatments reduce cocaine use by providing non-drug alternative reinforcers. The purpose of this human laboratory experiment was to determine how response cost for non-drug alternative reinforcers influenced cocaine choice. Seven cocaine-using, non-treatment-seeking subjects completed a crossover, double-blind protocol in which they first sampled doses of intranasal cocaine (5, 10, 20 or 30 mg) and completed a battery of subject-rated and physiological measures. Subjects then made eight discrete choices between the sampled dose and an alternative reinforce (US$0.25). The response cost to earn a cocaine dose was always a fixed ratio (FR) of 100 responses. The response cost for the alternative reinforcer varied across sessions (FR1, FR10, FR100, FR1000). Dose-related increases were observed for cocaine choice. Subjects made fewer drug choices when the FR requirements for the alternative reinforcers were lower than that for drug relative to when the FR requirements were equal to or higher than that for drug. Intranasal cocaine also produced prototypical stimulant-like subject-rated and physiological effects (e.g., increased ratings of Like Drug; elevated blood pressure). These data demonstrate that making alternative reinforcers easier to earn reduces cocaine self-administration, which has implications for treatment efforts. PMID:22015480

a Review on State-Of Face Recognition Approaches

NASA Astrophysics Data System (ADS)

Mahmood, Zahid; Muhammad, Nazeer; Bibi, Nargis; Ali, Tauseef

Automatic Face Recognition (FR) presents a challenging task in the field of pattern recognition and despite the huge research in the past several decades; it still remains an open research problem. This is primarily due to the variability in the facial images, such as non-uniform illuminations, low resolution, occlusion, and/or variation in poses. Due to its non-intrusive nature, the FR is an attractive biometric modality and has gained a lot of attention in the biometric research community. Driven by the enormous number of potential application domains, many algorithms have been proposed for the FR. This paper presents an overview of the state-of-the-art FR algorithms, focusing their performances on publicly available databases. We highlight the conditions of the image databases with regard to the recognition rate of each approach. This is useful as a quick research overview and for practitioners as well to choose an algorithm for their specified FR application. To provide a comprehensive survey, the paper divides the FR algorithms into three categories: (1) intensity-based, (2) video-based, and (3) 3D based FR algorithms. In each category, the most commonly used algorithms and their performance is reported on standard face databases and a brief critical discussion is carried out.

Salivary flow rate and pH in patients with oral pathologies.

PubMed

Foglio-Bonda, P L; Brilli, K; Pattarino, F; Foglio-Bonda, A

2017-01-01

Determine salivary pH and flow rate (FR) in a sample of 164 patients who came to Oral Pathology ambulatory, 84 suffering from oral lesions and 80 without oral lesions. Another aim was to evaluate factors that influence salivary flow rate. Subjects underwent clinical examination and completed an anamnestic questionnaire in order to obtain useful information that was used to classify participants in different groups. Unstimulated whole saliva (UWS) was collected using the spitting method at 11:00 am. The FR was evaluated with the weighing technique and a portable pHmeter, equipped with a microelectrode, was used to measure pH. Both univariate and classification (single and Random Forest) analyses were performed. The data analysis showed that FR and pH showed significant differences (p < 0.001) between patients with oral lesions (FR = 0.336 mL/min, pH = 6.69) and the ones without oral lesions (FR = 0.492 mL/min, pH = 6.96). By Random Forest, oral lesions and antihypertensive drugs were ranked in the top two among the evaluated variables to discretize subjects with FR = 0.16 mL/min. Our study shows that there is a relationship between oral lesions, antihypertensive drugs and alteration of pH and FR.

Aging Alters Functionally Human Dermal Papillary Fibroblasts but Not Reticular Fibroblasts: A New View of Skin Morphogenesis and Aging

PubMed Central

Mine, Solène; Fortunel, Nicolas O.; Pageon, Hervé; Asselineau, Daniel

2008-01-01

Understanding the contribution of the dermis in skin aging is a key question, since this tissue is particularly important for skin integrity, and because its properties can affect the epidermis. Characteristics of matched pairs of dermal papillary and reticular fibroblasts (Fp and Fr) were investigated throughout aging, comparing morphology, secretion of cytokines, MMPs/TIMPs, growth potential, and interaction with epidermal keratinocytes. We observed that Fp populations were characterized by a higher proportion of small cells with low granularity and a higher growth potential than Fr populations. However, these differences became less marked with increasing age of donors. Aging was also associated with changes in the secretion activity of both Fp and Fr. Using a reconstructed skin model, we evidenced that Fp and Fr cells do not possess equivalent capacities to sustain keratinopoiesis. Comparing Fp and Fr from young donors, we noticed that dermal equivalents containing Fp were more potent to promote epidermal morphogenesis than those containing Fr. These data emphasize the complexity of dermal fibroblast biology and document the specific functional properties of Fp and Fr. Our results suggest a new model of skin aging in which marked alterations of Fp may affect the histological characteristics of skin. PMID:19115004

Placement of percutaneous transhepatic biliary stent using a silicone drain with channels

PubMed Central

Yoshida, Hiroshi; Mamada, Yasuhiro; Taniai, Nobuhiko; Mineta, Sho; Mizuguchi, Yoshiaki; Kawano, Yoichi; Sasaki, Junpei; Nakamura, Yoshiharu; Aimoto, Takayuki; Tajiri, Takashi

2009-01-01

This report describes a method for percutaneous transhepatic biliary stenting with a BLAKE Silicone Drain, and discusses the usefulness of placement of the drain connected to a J-VAC Suction Reservoir for the treatment of stenotic hepaticojejunostomy. Percutaneous transhepatic biliary drainage was performed under ultrasonographic guidance in a patient with stenotic hepaticojejunostomy after hepatectomy for hepatic hilum malignancy. The technique used was as follows. After dilatation of the drainage root, an 11-Fr tube with several side holes was passed through the stenosis of the hepaticojejunostomy. A 10-Fr BLAKE Silicone Drain is flexible, which precludes one-step insertion. One week after insertion of the 11-Fr tube, a 0.035-inch guidewire was inserted into the tube. After removal of the 11-Fr tube, the guidewire was put into the channel of a 10-Fr BLAKE Silicone Drain. The drain was inserted into the jejunal limb through the intrahepatic bile duct and was connected to a J-VAC Suction Reservoir. Low-pressure continued suction was applied. Patients can be discharged after insertion of the 10-Fr BLAKE Silicone Drain connected to the J-VAC Suction Reservoir. Placement of a percutaneous transhepatic biliary stent using a 10-Fr BLAKE Silicone Drain connected to a J-VAC Suction Reservoir is useful for the treatment of stenotic hepaticojejunostomy. PMID:19725159

Modified first-order Hořava-Lifshitz gravity: Hamiltonian analysis of the general theory and accelerating FRW cosmology in a power-law F(R) model

NASA Astrophysics Data System (ADS)

Carloni, Sante; Chaichian, Masud; Nojiri, Shin'Ichi; Odintsov, Sergei D.; Oksanen, Markku; Tureanu, Anca

2010-09-01

We propose the most general modified first-order Hořava-Lifshitz gravity, whose action does not contain time derivatives higher than the second order. The Hamiltonian structure of this theory is studied in all the details in the case of the spatially-flat Friedmann-Robertson-Walker (FRW) space-time, demonstrating many of the features of the general theory. It is shown that, with some plausible assumptions, including the projectability of the lapse function, this model is consistent. As a large class of such theories, the modified Hořava-Lifshitz F(R) gravity is introduced. The study of its ultraviolet properties shows that its z=3 version seems to be renormalizable in the same way as the original Hořava-Lifshitz proposal. The Hamiltonian analysis of the modified Hořava-Lifshitz F(R) gravity shows that it is in general a consistent theory. The F(R) gravity action is also studied in the fixed-gauge form, where the appearance of a scalar field is particularly illustrative. Then the spatially-flat FRW cosmology for this F(R) gravity is investigated. It is shown that a special choice of parameters for this theory leads to the same equations of motion as in the case of traditional F(R) gravity. Nevertheless, the cosmological structure of the modified Hořava-Lifshitz F(R) gravity turns out to be much richer than for its traditional counterpart. The emergence of multiple de Sitter solutions indicates the possibility of unification of early-time inflation with late-time acceleration within the same model. Power-law F(R) theories are also investigated in detail. It is analytically shown that they have a quite rich cosmological structure: early-/late-time cosmic acceleration of quintessence, as well as of phantom types. Also it is demonstrated that all the four known types of finite-time future singularities may occur in the power-law Hořava-Lifshitz F(R) gravity. Finally, a covariant proposal for (renormalizable) F(R) gravity within the Hořava-Lifshitz spirit is presented.

The Adenosine A2A Receptor Agonist, CGS-21680, Blocks Excessive Rearing, Acquisition of Wheel Running, and Increases Nucleus Accumbens CREB Phosphorylation in Chronically Food-Restricted Rats

PubMed Central

de Vaca, Soledad Cabeza; Kannan, Pavitra; Pan, Yan; Jiang, Nancy; Sun, Yanjie; Carr, Kenneth D.

2007-01-01

Adenosine A2A receptors are preferentially expressed in rat striatum, where they are concentrated in dendritic spines of striatopallidal medium spiny neurons and exist in a heteromeric complex with D2 dopamine (DA) receptors. Behavioral and biochemical studies indicate an antagonistic relationship between A2A and D2 receptors. Previous studies have demonstrated that food-restricted (FR) rats display behavioral and striatal cellular hypersensitivity to D1 and D2 DA receptor stimulation. These alterations may underlie adaptive, as well as maladaptive, behaviors characteristic of the FR rat. The present study examined whether FR rats are hypersensitive to the A2A receptor agonist, CGS-21680. In Experiment 1, spontaneous horizontal motor activity did not differ between FR and ad libitum fed (AL) rats, while vertical activity was greater in the former. Intracerebroventricular (i.c.v.) administration of CGS-21680 (0.25 and 1.0 nmol) decreased both types of motor activity in FR rats, and returned vertical activity levels to those observed in AL rats. In Experiment 2, FR rats given access to a running wheel for a brief period outside of the home cage rapidly acquired wheel running while AL rats did not. Pretreatment with CGS-21680 (1.0 nmol) blocked the acquisition of wheel running. When administered to FR subjects that had previously acquired wheel running, CGS-21680 suppressed the behavior. In Experiment 3, CGS-21680 (1.0 nmol) activated both ERK 1/2 and CREB in caudate-putamen with no difference between feeding groups. However, in nucleus accumbens (NAc), CGS-21680 failed to activate ERK 1/2 and selectively activated CREB in FR rats. These results indicate that FR subjects are hypersensitive to several effects of an adenosine A2A agonist, and suggest the involvement of an upregulated A2A receptor-linked signaling pathway in NAc. Medications targeting the A2A receptor may have utility in the treatment of maladaptive behaviors associated with FR, including substance abuse and compulsive exercise. PMID:17292868

Feasibility of virtual 3-Fr percutaneous coronary intervention using standard guiding catheters

PubMed Central

Fujimoto, Kazuteru; Miyao, Yuji

2014-01-01

Introduction Recent studies have reported the efficacy of sheathless percutaneous coronary intervention (PCI) using hydrophilic-coated 5-Fr guiding catheters that are one to two Fr sizes smaller in diameter than the corresponding introducer sheath (virtual 3-Fr PCI). However, the limited number of shapes of hydrophilic-coated guiding catheters occasionally makes them difficult to engage and control. Aim To evaluate the efficacy and feasibility of virtual 3-Fr PCI using standard guiding catheters of various shapes. Material and methods We identified 35 consecutive patients with stable angina, who underwent virtual 3-Fr PCI using either hydrophilic-coated guiding catheters (Works™, Medikit, Japan) or standard guiding catheters (Heartrail™, Terumo, Japan). Results Thirty-five patients were identified (63% men; mean age 70 ±13 years). In 2 cases, hydrophilic-coated guiding catheters were exchanged to standard guiding catheters because of difficulty in engaging the target coronary arteries. Ultimately, standard guiding catheters were used in 20 patients (57%) and hydrophilic-coated catheters were used in 15 (43%). One of 20 patients treated with standard guiding catheters and 1 of 15 treated with hydrophilic-coated guiding catheters underwent the 4-in-3 “slender mother and child” PCI technique due to difficulty of stent deployment. There were no differences between the two groups in PCI procedural variables such as procedural time, fluoroscopy time, radiation dose, or contrast dye volume. There were no access site-related complications in this study. Conclusions These findings indicate that virtual 3-Fr PCI using standard guiding catheters is as efficient and safe as virtual 3-Fr PCI using hydrophilic-coated guiding catheters. PMID:25489315

Formation and Initiation of Erupting Flux Rope and Embedded Filament Driven by Photospheric Converging Motion

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhao Xiaozhou; Gan, Weiqun; Xia, Chun

2017-06-01

In this paper, we study how a flux rope (FR) is formed and evolves into the corresponding structure of a coronal mass ejection (CME) numerically driven by photospheric converging motion. A two-and-a-half-dimensional magnetohydrodynamics simulation is conducted in a chromosphere-transition-corona setup. The initial arcade-like linear force-free magnetic field is driven by an imposed slow motion converging toward the magnetic inversion line at the bottom boundary. The convergence brings opposite-polarity magnetic flux to the polarity inversion, giving rise to the formation of an FR by magnetic reconnection and eventually to the eruption of a CME. During the FR formation, an embedded prominencemore » gets formed by the levitation of chromospheric material. We confirm that the converging flow is a potential mechanism for the formation of FRs and a possible triggering mechanism for CMEs. We investigate the thermal, dynamical, and magnetic properties of the FR and its embedded prominence by tracking their thermal evolution, analyzing their force balance, and measuring their kinematic quantities. The phase transition from the initiation phase to the acceleration phase of the kinematic evolution of the FR was observed in our simulation. The FR undergoes a series of quasi-static equilibrium states in the initiation phase; while in the acceleration phase the FR is driven by Lorentz force and the impulsive acceleration occurs. The underlying physical reason for the phase transition is the change of the reconnection mechanism from the Sweet–Parker to the unsteady bursty regime of reconnection in the evolving current sheet underneath the FR.« less

Metabolic Fate of Fructose Ingested with and without Glucose in a Mixed Meal

PubMed Central

Theytaz, Fanny; de Giorgi, Sara; Hodson, Leanne; Stefanoni, Nathalie; Rey, Valentine; Schneiter, Philippe; Giusti, Vittorio; Tappy, Luc

2014-01-01

Ingestion of pure fructose stimulates de novo lipogenesis and gluconeogenesis. This may however not be relevant to typical nutritional situations, where fructose is invariably ingested with glucose. We therefore assessed the metabolic fate of fructose incorporated in a mixed meal without or with glucose in eight healthy volunteers. Each participant was studied over six hours after the ingestion of liquid meals containing either 13C-labelled fructose, unlabeled glucose, lipids and protein (Fr + G) or 13C-labelled fructose, lipids and protein, but without glucose (Fr), or protein and lipids alone (ProLip). After Fr + G, plasma 13C-glucose production accounted for 19.0% ± 1.5% and 13CO2 production for 32.2% ± 1.3% of 13C-fructose carbons. After Fr, 13C-glucose production (26.5% ± 1.4%) and 13CO2 production (36.6% ± 1.9%) were higher (p < 0.05) than with Fr + G. 13C-lactate concentration and very low density lipoprotein VLDL 13C-palmitate concentrations increased to the same extent with Fr + G and Fr, while chylomicron 13C-palmitate tended to increase more with Fr + G. These data indicate that gluconeogenesis, lactic acid production and both intestinal and hepatic de novo lipogenesis contributed to the disposal of fructose carbons ingested together with a mixed meal. Co-ingestion of glucose decreased fructose oxidation and gluconeogenesis and tended to increase 13C-pamitate concentration in gut-derived chylomicrons, but not in hepatic-borne VLDL-triacylglycerol (TG). This trial was approved by clinicaltrial. gov. Identifier is NCT01792089. PMID:25029210

The Santiago-Harvard-Edinburgh-Durham void comparison - I. SHEDding light on chameleon gravity tests

NASA Astrophysics Data System (ADS)

Cautun, Marius; Paillas, Enrique; Cai, Yan-Chuan; Bose, Sownak; Armijo, Joaquin; Li, Baojiu; Padilla, Nelson

2018-05-01

We present a systematic comparison of several existing and new void-finding algorithms, focusing on their potential power to test a particular class of modified gravity models - chameleon f(R) gravity. These models deviate from standard general relativity (GR) more strongly in low-density regions and thus voids are a promising venue to test them. We use halo occupation distribution (HOD) prescriptions to populate haloes with galaxies, and tune the HOD parameters such that the galaxy two-point correlation functions are the same in both f(R) and GR models. We identify both three-dimensional (3D) voids and two-dimensional (2D) underdensities in the plane of the sky to find the same void abundance and void galaxy number density profiles across all models, which suggests that they do not contain much information beyond galaxy clustering. However, the underlying void dark matter density profiles are significantly different, with f(R) voids being more underdense than GR ones, which leads to f(R) voids having a larger tangential shear signal than their GR analogues. We investigate the potential of each void finder to test f(R) models with near-future lensing surveys such as EUCLID and LSST. The 2D voids have the largest power to probe f(R) gravity, with an LSST analysis of tunnel (which is a new type of 2D underdensity introduced here) lensing distinguishing at 80 and 11σ (statistical error) f(R) models with parameters, |fR0| = 10-5 and 10-6, from GR.

Cross-cultural adaptation and validation of the Ankle Osteoarthritis Scale for use in French-speaking populations.

PubMed

Angers, Magalie; Svotelis, Amy; Balg, Frederic; Allard, Jean-Pascal

2016-04-01

The Ankle Osteoarthritis Scale (AOS) is a self-administered score specific for ankle osteoarthritis (OA) with excellent reliability and strong construct and criterion validity. Many recent randomized multicentre trials have used the AOS, and the involvement of the French-speaking population is limited by the absence of a French version. Our goal was to develop a French version and validate the psychometric properties to assure equivalence to the original English version. Translation was performed according to American Association of Orthopaedic Surgeons (AAOS) 2000 guidelines for cross-cultural adaptation. Similar to the validation process of the English AOS, we evaluated the psychometric properties of the French version (AOS-Fr): criterion validity (AOS-Fr v. Western Ontario and McMaster Universities Arthritis Index [WOMAC] and SF-36 scores), construct validity (AOS-Fr correlation to single heel-lift test), and reliability (AOS-Fr test-retest). Sixty healthy individuals tested a prefinal version of the AOS-Fr for comprehension, leading to modifications and a final version that was approved by C. Saltzman, author of the AOS. We then recruited patients with ankle OA for evaluation of the AOS-Fr psychometric properties. Twenty-eight patients with ankle OA participated in the evaluation. The AOS-Fr showed strong criterion validity (AOS:WOMAC r = 0.709 and AOS:SF-36 r = -0.654) and construct validity (r = 0.664) and proved to be reliable (test-retest intraclass correlation coefficient = 0.922). The AOS-Fr is a reliable and valid score equivalent to the English version in terms of psychometric properties, thus is available for use in multicentre trials.