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Sample records for ac driving force

  1. Forces Driving Chaperone Action.

    PubMed

    Koldewey, Philipp; Stull, Frederick; Horowitz, Scott; Martin, Raoul; Bardwell, James C A

    2016-07-14

    It is still unclear what molecular forces drive chaperone-mediated protein folding. Here, we obtain a detailed mechanistic understanding of the forces that dictate the four key steps of chaperone-client interaction: initial binding, complex stabilization, folding, and release. Contrary to the common belief that chaperones recognize unfolding intermediates by their hydrophobic nature, we discover that the model chaperone Spy uses long-range electrostatic interactions to rapidly bind to its unfolded client protein Im7. Short-range hydrophobic interactions follow, which serve to stabilize the complex. Hydrophobic collapse of the client protein then drives its folding. By burying hydrophobic residues in its core, the client's affinity to Spy decreases, which causes client release. By allowing the client to fold itself, Spy circumvents the need for client-specific folding instructions. This mechanism might help explain how chaperones can facilitate the folding of various unrelated proteins. PMID:27293188

  2. Phase-locking of driven vortex lattices with transverse ac force and periodic pinning

    SciTech Connect

    Reichhardt, Charles; Kolton, Alejandro B.; Dominguez, Daniel; Gronbech-Jensen, Niels

    2001-10-01

    For a vortex lattice moving in a periodic array we show analytically and numerically that a new type of phase locking occurs in the presence of a longitudinal dc driving force and a transverse ac driving force. This phase locking is distinct from the Shapiro step phase locking found with longitudinal ac drives. We show that an increase in critical current and a fundamental phase-locked step width scale with the square of the driving ac amplitude. Our results should carry over to other systems such as vortex motion in Josephson-junction arrays.

  3. Shapiro steps for skyrmion motion on a washboard potential with longitudinal and transverse ac drives

    NASA Astrophysics Data System (ADS)

    Reichhardt, C.; Reichhardt, C. J. Olson

    2015-12-01

    We numerically study the behavior of two-dimensional skyrmions in the presence of a quasi-one-dimensional sinusoidal substrate under the influence of externally applied dc and ac drives. In the overdamped limit, when both dc and ac drives are aligned in the longitudinal direction parallel to the direction of the substrate modulation, the velocity-force curves exhibit classic Shapiro step features when the frequency of the ac drive matches the washboard frequency that is dynamically generated by the motion of the skyrmions over the substrate, similar to previous observations in superconducting vortex systems. In the case of skyrmions, the additional contribution to the skyrmion motion from a nondissipative Magnus force shifts the location of the locking steps to higher dc drives, and we find that the skyrmions move at an angle with respect to the direction of the dc drive. For a longitudinal dc drive and a perpendicular or transverse ac drive, the overdamped system exhibits no Shapiro steps; however, when a finite Magnus force is present, we find pronounced transverse Shapiro steps along with complex two-dimensional periodic orbits of the skyrmions in the phase-locked regimes. Both the longitudinal and transverse ac drives produce locking steps whose widths oscillate with increasing ac drive amplitude. We examine the role of collective skyrmion interactions and find that additional fractional locking steps occur for both longitudinal and transverse ac drives. At higher skyrmion densities, the system undergoes a series of dynamical order-disorder transitions, with the skyrmions forming a moving solid on the phase locking steps and a fluctuating dynamical liquid in regimes between the steps.

  4. ACS Task Force Frames Recommendations on Education.

    ERIC Educational Resources Information Center

    Chemical and Engineering News, 1984

    1984-01-01

    Discusses findings and recommendations of an American Chemical Society (ACS) task force study on the status of chemical education in the United States. Recommendations relate to national concerns; all educational levels; elementary, secondary, university, college, and two-year college chemistry and science; chemistry careers; and industry and…

  5. Measurement of coupling resonance driving terms with the AC dipole

    SciTech Connect

    Miyamoto, R.

    2010-10-01

    Resonance driving terms for linear coupled betatron motion in a synchrotron ring can be determined from corresponding spectral lines of an excited coherent beam motion. An AC dipole is one of instruments to excite such a motion. When a coherent motion is excited with an AC dipole, measured Courant-Snyder parameters and betatron phase advance have apparent modulations, as if there is an additional quadrupole field at the location of the AC dipole. Hence, measurements of these parameters using the AC dipole require a proper interpretation of observed quantities. The situation is similar in measurements of resonance driving terms using the AC dipole. In this note, we derive an expression of coupled betatron motion excited with two AC dipoles in presence of skew quadrupole fields, discuss an impact of this quadrupole like effect of the AC dipole on a measurement of coupling resonance driving terms, and present an analytical method to determine the coupling resonance driving terms from quantities observed using the AC dipole.

  6. Sequential control by speed drive for ac motor

    NASA Astrophysics Data System (ADS)

    Barsoum, Nader

    2012-11-01

    The speed drive for ac motor is widely used in the industrial field to allow direct control for the speed and torque without any feedback from the motor shaft. By using the ABB ACS800 speed drive unit, the speed and torque can be controlled using sequential control method. Sequential control is one of the application control method provided in the ABB ACS800 Drive, where a set of events or action performed in a particular order one after the other to control the speed and torque of the ac motor. It was claimed that sequential control method is using the preset seven constant speeds being provided in ABB ACS800 drive to control the speed and torque in a continuous and sequential manner. The characteristics and features of controlling the speed and torque using sequential control method can be investigated by observing the graphs and curves plotted which are obtained from the practical result. Sequential control can run either in the Direct Torque Control (DTC) or Scalar motor control mode. By using sequential control method, the ABB ACS800 drive can be programmed to run the motor automatically according to the time setting of the seven preset constant speeds. Besides, the intention of this project is to generate a new form of the experimental set up.

  7. Scalar control on speed drive for ac motor

    NASA Astrophysics Data System (ADS)

    Barsoum, Nader

    2012-11-01

    This paper aims to investigate the performance of ABB ACS800 variable speed drive operating under Scalar Control mode, and eventually develop a set of experimental procedures for undergraduate laboratory purposes. Scalar Control is the most widespread form of ac drive, for its low cost and simplicity especially implemented in the open loop mode. Scalar control is achieved by controlling the stator voltage and frequency, thus maintaining the motor's air-gap flux at a constant value. To illustrate the control method, the ac drive is configured according to the wiring diagram in the firmware manual that the drive control location can be both local and external. The drive is selected to operate under Factory application macro, whereby either ordinary speed control applications or constant speeds applications may be used. Under ordinary speed control, frequency reference signals are provided to the drive through the analogue input AI1. The drive will operate at the given frequency reference value throughout the operation regardless of any changes in the load. The torque speed curve moves along the speed axis with no changes to the shape as the supply frequencies changes. On the other hand, the drive allows three preset constant speed through digital inputs DI5 and DI6. The drive operate at a constant speed value over a time period, and only switch from one constant speed to another constant speed by triggering the two input switches. Scalar control is most suitable for applications not required high precision, such as blowers, fans and pumps.

  8. Forces driving epithelial wound healing

    NASA Astrophysics Data System (ADS)

    Brugués, Agustí; Anon, Ester; Conte, Vito; Veldhuis, Jim H.; Gupta, Mukund; Colombelli, Julien; Muñoz, José J.; Brodland, G. Wayne; Ladoux, Benoit; Trepat, Xavier

    2014-09-01

    A fundamental feature of multicellular organisms is their ability to self-repair wounds through the movement of epithelial cells into the damaged area. This collective cellular movement is commonly attributed to a combination of cell crawling and `purse-string’ contraction of a supracellular actomyosin ring. Here we show by direct experimental measurement that these two mechanisms are insufficient to explain force patterns observed during wound closure. At early stages of the process, leading actin protrusions generate traction forces that point away from the wound, showing that wound closure is initially driven by cell crawling. At later stages, we observed unanticipated patterns of traction forces pointing towards the wound. Such patterns have strong force components that are both radial and tangential to the wound. We show that these force components arise from tensions transmitted by a heterogeneous actomyosin ring to the underlying substrate through focal adhesions. The structural and mechanical organization reported here provides cells with a mechanism to close the wound by cooperatively compressing the underlying substrate.

  9. Forces driving epithelial wound healing

    PubMed Central

    Veldhuis, Jim H.; Gupta, Mukund; Colombelli, Julien; Muñoz, José J.; Brodland, G. Wayne; Ladoux, Benoit; Trepat, Xavier

    2015-01-01

    A fundamental feature of multicellular organisms is their ability to self-repair wounds through the movement of epithelial cells into the damaged area. This collective cellular movement is commonly attributed to a combination of cell crawling and “purse-string” contraction of a supracellular actomyosin ring. Here we show by direct experimental measurement that these two mechanisms are insufficient to explain force patterns observed during wound closure. At early stages of the process, leading actin protrusions generate traction forces that point away from the wound, showing that wound closure is initially driven by cell crawling. At later stages, we observed unanticipated patterns of traction forces pointing towards the wound. Such patterns have strong force components that are both radial and tangential to the wound. We show that these force components arise from tensions transmitted by a heterogeneous actomyosin ring to the underlying substrate through focal adhesions. The structural and mechanical organization reported here provides cells with a mechanism to close the wound by cooperatively compressing the underlying substrate. PMID:27340423

  10. Unraveling Base Stacking Driving Forces in DNA.

    PubMed

    Mak, Chi H

    2016-07-01

    Base stacking is a key determinant of nucleic acid structures, but the precise origin of the thermodynamic driving force behind the stacking of nucleobases remains open. The rather mild stacking free energy measured experimentally, roughly a kcal/mol depending on the identity of the bases, is physiologically significant because while base stacking confers stability to the genome in its double helix form, the duplex also has to be unwound in order to be replicated or transcribed. A stacking free energy that is either too high or too low will over- or understabilize the genome, impacting the storage of genetic information and also its retrieval. While the molecular origin of stacking driving force has been attributed to many different sources including dispersion, electrostatics, and solvent hydrogen bonding, here we show via a systematic decomposition of the stacking free energy using large-scale computer simulations that the dominant driving force stabilizing base stacking is nonhydrophobic solvent entropy. Counteracting this is the conformational entropic penalty on the sugar-phosphate backbone against stacking, while solvent hydrogen-bonding, charge-charge interactions, and dispersive forces produce only secondary perturbations. Solvent entropic forces and DNA backbone conformational strains therefore work against each other, leading to a very mild composite stacking free energy in agreement with experiments. PMID:27045853

  11. Designing LC filters for AC-motor drives

    SciTech Connect

    Gath, P.A.; Lucas, M.

    1995-12-31

    This paper presents practical design guidelines for designing LC filters for AC-motor drive applications. A DC choke and an electrolytic capacitor bank on the DC bus filter the voltage and the current ripples and improve the input power factor. Capacitor and choke values are derived to optimize overall filter performance. Costs associated with the respective component values can then be obtained to analyze cost trade-offs between selected values. Helpful hints are also given.

  12. Controlling Casimir force via coherent driving field

    NASA Astrophysics Data System (ADS)

    Ahmad, Rashid; Abbas, Muqaddar; Ahmad, Iftikhar; Qamar, Sajid

    2016-04-01

    A four level atom-field configuration is used to investigate the coherent control of Casimir force between two identical plates made up of chiral atomic media and separated by vacuum of width d. The electromagnetic chirality-induced negative refraction is obtained via atomic coherence. The behavior of Casimir force is investigated using Casimir-Lifshitz formula. It is noticed that Casimir force can be switched from repulsive to attractive and vice versa via coherent control of the driving field. This switching feature provides new possibilities of using the repulsive Casimir force in the development of new emerging technologies, such as, micro-electro-mechanical and nano-electro-mechanical systems, i.e., MEMS and NEMS, respectively.

  13. Study of scratch drive actuator force characteristics

    NASA Astrophysics Data System (ADS)

    Li, Lijie; Brown, J. Gordon; Uttamchandani, Deepak

    2002-11-01

    Microactuators are one of the key components in MEMS technology, and various designs have been realized through different fabrication processes. One type of microactuator commonly used is the scratch drive actuator (SDA) that is frequently fabricated by surface micromachining processes. An experimental investigation has been conducted on the force characteristics of SDAs fabricated using the JDSU Microsystems MUMPs process. One-, two-, three- and four-plate SDAs connected to box-springs have been designed and fabricated for these experiments using MUMPs run 44. The spring constant for the box-springs has been calculated by FEM using ANSYS software. The product of the spring constant and spring extension is used to measure the forces produced by these SDAs. It is estimated that the forces produced exceed 250 μN from a one-plate SDA and 850 μN from a four-plate SDA.

  14. A driving scheme to reduce AC LED flicker

    NASA Astrophysics Data System (ADS)

    Tan, Jianchuan; Narendran, Nadarajah

    2013-09-01

    Light flicker is a common but unwelcome phenomenon in conventional lighting applications. In solid-state lighting, driving or dimming methods also give rise to light flicker. AC LED products in today's marketplace suffer from flicker, which stems from the arrangement of the micro-LEDs and the driving method. Research has shown that light flicker can be a health hazard to humans. Several solutions have been proposed to reduce light flicker in solid-state lighting applications; however, most have drawbacks in terms of power and other performance. This paper proposes a circuit design to reduce light flicker from AC LEDs while maintaining a normal power factor and high power efficiency. The circuit is composed of one resistive branch and one capacitive branch, and each branch drives a load which is made up of high-voltage LEDs. Percent flicker, power factor, and power efficiency were selected as three metrics, and their benchmarks were set to evaluate the performance of this circuit. Phase shift between the two branches was selected as a factor that could determine the circuit performance. The variations of percent flicker, power factor, and power efficiency as a function of phase shift were identified by theoretical analysis and were verified by experiments. The experimental results show that an optimal solution can be achieved for this circuit design at proper phase shift, where the benchmarks of the three metrics are reached.

  15. A PWM transistor inverter for an ac electric vehicle drive

    NASA Technical Reports Server (NTRS)

    Slicker, J. M.

    1981-01-01

    A prototype system consisting of closely integrated motor, inverter, and transaxle has been built in order to demonstrate the feasibility of a three-phase ac transistorized inverter for electric vehicle applications. The microprocessor-controlled inverter employs monolithic power transistors to drive an oil-cooled, three-phase induction traction motor at a peak output power of 30 kW from a 144 V battery pack. Transistor safe switching requirements are discussed, and a circuit is presented for recovering trapped snubber inductor energy at transistor turn-off.

  16. Driving forces behind integration: weigh your options.

    PubMed

    Friend, P M; Meighan, S

    1994-01-01

    Collaborative relationships between hospitals and physicians can take many forms. Before you choose your strategy, consider the benefits and drawbacks of each. Many of America's hospitals and physicians are rushing to integrate their services through a variety of collaborative options. Their haste has been encouraged by many factors. Before hospitals and physicians react to the driving forces around them, they should carefully consider the pros and cons of four types of collaborative options: 1. management service organizations, 2. physician-hospital organizations, 3. practice acquisition models, 4. equity models. PMID:10133599

  17. An AC drive system for a battery driven moped

    SciTech Connect

    Nandi, S.; Saha, S.; Sharon, M.; Sundersingh, V.P.

    1995-12-31

    A petrol driven moped is converted to an electric one by replacing the petrol engine by a three phase 1.5 HR, AC squirrel cage induction motor drive system. The motor voltage rating selected is 200 V to keep the DC boost voltage level to a reasonable value.f the power source used is a high energy density, 24 V, 110 Ah, Ni-Zn battery. A modified indirect current controlled step-up chopper as well as a standard push-pull DC-DC boost converter is studied for the boost scheme. A simple three phase quasi-square wave inverter is designed along with suitable protection for driving the motor. Successful trial test of the system has been conducted at the laboratory.

  18. On the evolution of ac machines for spindle drive applications

    SciTech Connect

    Fratta, A.; Vagati, A.; Villata, F. )

    1992-10-01

    In the field of ac spindle drives, the induction motor is widely adopted. Synchronous solutions (reluctance, interior permanent magnets) are often suggested to overcome some drawbacks of the induction motor. This paper compares the different options by considering the machine torque-density and the inverter power size needed for a given constant-power speed range. It is shown that an axially laminated reluctance motor gives more torque density than the induction motor but nearly requires the same inverter size. By adding a proper quantity of permanent magnets, the inverter size can be greatly reduced. A comprehensive discussion is made on this subject, aiming to point out a design solution that is 'optimal' for the whole drive.

  19. System and method for determining stator winding resistance in an AC motor using motor drives

    DOEpatents

    Lu, Bin; Habetler, Thomas G; Zhang, Pinjia

    2013-02-26

    A system and method for determining the stator winding resistance of AC motors is provided. The system includes an AC motor drive having an input connectable to an AC source and an output connectable to an input terminal of an AC motor, a pulse width modulation (PWM) converter having switches therein to control current flow and terminal voltages in the AC motor, and a control system connected to the PWM converter. The control system generates a command signal to cause the PWM converter to control an output of the AC motor drive corresponding to an input to the AC motor, selectively generates a modified command signal to cause the PWM converter to inject a DC signal into the output of the AC motor drive, and determines a stator winding resistance of the AC motor based on the DC signal of at least one of the voltage and current.

  20. Forces driving epithelial spreading in zebrafish gastrulation.

    PubMed

    Behrndt, Martin; Salbreux, Guillaume; Campinho, Pedro; Hauschild, Robert; Oswald, Felix; Roensch, Julia; Grill, Stephan W; Heisenberg, Carl-Philipp

    2012-10-12

    Contractile actomyosin rings drive various fundamental morphogenetic processes ranging from cytokinesis to wound healing. Actomyosin rings are generally thought to function by circumferential contraction. Here, we show that the spreading of the enveloping cell layer (EVL) over the yolk cell during zebrafish gastrulation is driven by a contractile actomyosin ring. In contrast to previous suggestions, we find that this ring functions not only by circumferential contraction but also by a flow-friction mechanism. This generates a pulling force through resistance against retrograde actomyosin flow. EVL spreading proceeds normally in situations where circumferential contraction is unproductive, indicating that the flow-friction mechanism is sufficient. Thus, actomyosin rings can function in epithelial morphogenesis through a combination of cable-constriction and flow-friction mechanisms. PMID:23066079

  1. Numerical calculations of the driving force on an Abrikosov vortex

    NASA Astrophysics Data System (ADS)

    Chen, D.-X.; Pardo, E.; Sanchez, A.

    2010-05-01

    The driving force on an Abrikosov vortex is calculated numerically from the London equation and involved energies for a vortex perpendicular to the screening current near the surface of a superconductor. Compared with previous analytical derivation of the total force, the partial magnetic, kinematic, and external forces are also obtained so that the nature of the driving force may be deeply discussed. It is shown that the force is neither a Lorentz force nor a Magnus force as often believed and that in order to get a correct result, the image effects and the work done by the applied field must be taken into account. A name of London force is suggested for the driving force. A deep understanding of the nature of the driving force on Abrikosov vortices may also be important in the study of vortex pinning and dynamics in type-II superconductors.

  2. Sensor-less pseudo-sinusoidal drive for a permanent-magnet brushless ac motor

    NASA Astrophysics Data System (ADS)

    Liu, Li-Hsiang; Chern, Tzuen-Lih; Pan, Ping-Lung; Huang, Tsung-Mou; Tsay, Der-Min; Kuang, Jao-Hwa

    2012-04-01

    The precise rotor-position information is required for a permanent-magnet brushless ac motor (BLACM) drive. In the conventional sinusoidal drive method, either an encoder or a resolver is usually employed. For position sensor-less vector control schemes, the rotor flux estimation and torque components are obtained by complicated coordinate transformations. These computational intensive methods are susceptible to current distortions and parameter variations. To simplify the method complexity, this work presents a sensor-less pseudo-sinusoidal drive scheme with speed control for a three-phase BLACM. Based on the sinusoidal drive scheme, a floating period of each phase current is inserted for back electromotive force detection. The zero-crossing point is determined directly by the proposed scheme, and the rotor magnetic position and rotor speed can be estimated simultaneously. Several experiments for various active angle periods are undertaken. Furthermore, a current feedback control is included to minimize and compensate the torque fluctuation. The experimental results show that the proposed method has a competitive performance compared with the conventional drive manners for BLACM. The proposed scheme is straightforward, bringing the benefits of sensor-less drive and negating the need for coordinate transformations in the operating process.

  3. Power Electronic Transformer based Three-Phase PWM AC Drives

    NASA Astrophysics Data System (ADS)

    Basu, Kaushik

    A Transformer is used to provide galvanic isolation and to connect systems at different voltage levels. It is one of the largest and most expensive component in most of the high voltage and high power systems. Its size is inversely proportional to the operating frequency. The central idea behind a power electronic transformer (PET) also known as solid state transformer is to reduce the size of the transformer by increasing the frequency. Power electronic converters are used to change the frequency of operation. Steady reduction in the cost of the semiconductor switches and the advent of advanced magnetic materials with very low loss density and high saturation flux density implies economic viability and feasibility of a design with high power density. Application of PET is in generation of power from renewable energy sources, especially wind and solar. Other important application include grid tied inverters, UPS e.t.c. In this thesis non-resonant, single stage, bi-directional PET is considered. The main objective of this converter is to generate adjustable speed and magnitude pulse width modulated (PWM) ac waveforms from an ac or dc grid with a high frequency ac link. The windings of a high frequency transformer contains leakage inductance. Any switching transition of the power electronic converter connecting the inductive load and the transformer requires commutation of leakage energy. Commutation by passive means results in power loss, decrease in the frequency of operation, distortion in the output voltage waveform, reduction in reliability and power density. In this work a source based partially loss-less commutation of leakage energy has been proposed. This technique also results in partial soft-switching. A series of converters with novel PWM strategies have been proposed to minimize the frequency of leakage inductance commutation. These PETs achieve most of the important features of modern PWM ac drives including 1) Input power factor correction, 2) Common

  4. Direct Experimental Observation of a Practical AC Zeeman Force

    NASA Astrophysics Data System (ADS)

    Fancher, Charles; Pyle, Andrew; Rotunno, Andrew; Du, Shuangli; Aubin, Seth

    2016-05-01

    We present measurements of the spin-dependent AC Zeeman force produced by microwave magnetic near-field gradients on an atom chip. We measure the AC Zeeman force on ultracold 87 Rb atoms by observing its effect on the motion of atoms in free-fall and on those confined in a trap. We have studied the force as a function of microwave frequency detuning from a hyperfine transition at 6.8 GHz at several magnetic field strengths and have observed its characteristic bipolar and resonant features predicted by two-level dressed atom theory. We find that the force is several times the strength of gravity in our setup, and that it can be targeted to a specific hyperfine transition while leaving other hyperfine states and transitions relatively unaffected. We find that our measurements are reasonably consistent with theory and are working towards a parameter-free comparison. AC Zeeman potentials offer the possibility of targeting qualitatively different trapping potentials to different spin states, a capability currently absent from the toolbox of atomic quantum control techniques. In particular, an AC Zeeman potential could be used as the beamsplitter for a spin-dependent atom interferometer or for engineering a quantum gate. Work supported by AFOSR and W&M, and in part by AFRL.

  5. Efficiency optimal control for AC drives with PWM inverters

    SciTech Connect

    Zach, F.C.; Ertl, H.

    1985-07-01

    For electrical drives using pulsewidth modulation (PWM) inverters and ac motors, methods for efficiency optimal control (EOC) have been developed. They are based on the most complete motor models, including such features as rotor skin effect. Furthermore, new solutions for selected harmonic elimination (SHE) are given. These new solutions come close to EOC. Also, it has been found that EOC solutions (although basically load-dependent as opposed to SHE) do not vary much with the motor used or the motor model applied. Even using a simple R-L series circuit as motor model does not change the solutions much. It is found that using the solutions gained from such a simple model is not more than two points off the real optimum based on a very complete motor model. (For this definition, the absolute harmonic loss minimum is given as zero points, the overall maximum as 100 points with a linear scale in between.) Therefore, one can use one EOC solution for all motors with sufficient accuracy, or, as second best solution, the new form of SHE. Therefore, the EOC solution can be judged load-independent. The implementation by microprocessor-based systems is as easy for other PWM methods. EOC for three and five switching angles per quarter period is discussed, as well as the new solutions for SHE for up to nine angles.

  6. Stability improvement of AC superconducting magnet by forced-convection cooling

    SciTech Connect

    Ishigohka, T.; Kasuya, A.; Ninomiya, A.

    1996-07-01

    The authors propose a new improved cooling system of an AC(50/60Hz) superconducting magnet introducing a forced-convection flow of liquid helium. In this system, the flow through the cooling channel between the winding layers is generated by a screw rotating in a cylinder surrounding the magnet. A small experimental device composed of an AC superconducting magnet and a rotating screw was manufactured. The screw was rotated by an extended driving shaft. The experimental result shows that the stability of the magnet is improved by the rotation of the screw. That is, the thermal disturbance (heater input power) which generates the quench of the magnet increases as the rotational speed of the screw does. It is expected that this technique can be successfully applied to superconducting AC power apparatuses as transformers or reactors.

  7. Inversion for the driving forces of plate tectonics

    NASA Technical Reports Server (NTRS)

    Richardson, R. M.

    1983-01-01

    Inverse modeling techniques have been applied to the problem of determining the roles of various forces that may drive and resist plate tectonic motions. Separate linear inverse problems have been solved to find the best fitting pole of rotation for finite element grid point velocities and to find the best combination of force models to fit the observed relative plate velocities for the earth's twelve major plates using the generalized inverse operator. Variance-covariance data on plate motion have also been included. Results emphasize the relative importance of ridge push forces in the driving mechanism. Convergent margin forces are smaller by at least a factor of two, and perhaps by as much as a factor of twenty. Slab pull, apparently, is poorly transmitted to the surface plate as a driving force. Drag forces at the base of the plate are smaller than ridge push forces, although the sign of the force remains in question.

  8. Comparison of AC drives for electric vehicles -- A report on experts` opinion survey

    SciTech Connect

    Chang, L.

    1994-08-01

    It is recognized that wide applications of electric vehicles (EVs) will bring tremendous social, economical and ecological benefits. With the growing interests in electric vehicles, much effort is demanded for the development of efficient, reliable and economical AC drives` for EV propulsion purpose. Both induction motor (IM) drives and permanent magnet brushless DC motor (BDCM) drives have been applied to EVs. Switched reluctance motor (SRM) drives have been proposed as an alternative for EV propulsion. In order to assess the suitability of IM, BDCM and SRM drives for EV applications and to provide a technical support for the development and selection of future EV propulsion systems, the existing EV AC propulsion drives were compared, and a survey of experts` opinions was conducted. Comparison of the three AC drives was made on a relative and a quantitative basis using the survey questionnaires. According to the majority of the experts, induction motor drives are best suited for EV propulsion purpose, due to their low cost, high reliability, high speed, established converter and manufacturing technology, low torque ripple/noise and absence of position sensors. BDCM drives feature compactness, low weight and high efficiency and therefore provide an alternative for EV propulsion. The experts regard insulated gate bipolar transistors (IGBTs) as the most suited power semiconductor devices for AC drive converters at the present stage. 7 refs.

  9. OSHA Laboratory Standard: Driving Force for Laboratory Safety!

    ERIC Educational Resources Information Center

    Roy, Kenneth R.

    2000-01-01

    Discusses the Occupational Safety and Health Administration's (OSHA's) Laboratory Safety Standards as the major driving force in establishing and maintaining a safe working environment for teachers and students. (Author)

  10. Vaccine Refusal a Driving Force Behind Measles Outbreaks, Study Finds

    MedlinePlus

    ... nlm.nih.gov/medlineplus/news/fullstory_157778.html Vaccine Refusal a Driving Force Behind Measles Outbreaks, Study ... than half of the cases involved unvaccinated children. Vaccine refusal was also often the culprit in whooping ...

  11. Entropic forces drive contraction of cytoskeletal networks.

    PubMed

    Braun, Marcus; Lansky, Zdenek; Hilitski, Feodor; Dogic, Zvonimir; Diez, Stefan

    2016-05-01

    The cytoskeleton is a network of interconnected protein filaments, which provide a three-dimensional scaffold for cells. Remodeling of the cytoskeleton is important for key cellular processes, such as cell motility, division, or morphogenesis. This remodeling is traditionally considered to be driven exclusively by processes consuming chemical energy, such as the dynamics of the filaments or the action of molecular motors. Here, we review two mechanisms of cytoskeletal network remodeling that are independent of the consumption of chemical energy. In both cases directed motion of overlapping filaments is driven by entropic forces, which arise from harnessing thermal energy present in solution. Entropic forces are induced either by macromolecular crowding agents or by diffusible crosslinkers confined to the regions where filaments overlap. Both mechanisms increase filament overlap length and lead to the contraction of filament networks. These force-generating mechanisms, together with the chemical energy-dependent mechanisms, need to be considered for the comprehensive quantitative picture of the remodeling of cytoskeletal networks in cells. PMID:26996935

  12. Developing pressures: fluid forces driving morphogenesis.

    PubMed

    Navis, Adam; Bagnat, Michel

    2015-06-01

    Over several decades genetic studies have unraveled many molecular mechanisms that underlie the signaling networks guiding morphogenesis, but the mechanical forces at work remain much less well understood. Accumulation of fluid within a luminal space can generate outward hydrostatic pressure capable of shaping morphogenesis at several scales, ranging from individual organs to the entire vertebrate body-plan. Here, we focus on recent work that uncovered mechanical roles for fluid secretion during morphogenesis. Identifying the roles and regulation of fluid secretion will be instrumental for understanding the mechanics of morphogenesis as well as many human diseases of complex genetic and environmental origin including secretory diarrheas and scoliosis. PMID:25698116

  13. Driving forces: Slab subduction and mantle convection

    NASA Technical Reports Server (NTRS)

    Hager, Bradford H.

    1988-01-01

    Mantle convection is the mechanism ultimately responsible for most geological activity at Earth's surface. To zeroth order, the lithosphere is the cold outer thermal boundary layer of the convecting mantle. Subduction of cold dense lithosphere provides tha major source of negative buoyancy driving mantle convection and, hence, surface tectonics. There are, however, importnat differences between plate tectonics and the more familiar convecting systems observed in the laboratory. Most important, the temperature dependence of the effective viscosity of mantle rocks makes the thermal boundary layer mechanically strong, leading to nearly rigid plates. This strength stabilizes the cold boundary layer against small amplitude perturbations and allows it to store substantial gravitational potential energy. Paradoxically, through going faults at subduction zones make the lithosphere there locally weak, allowing rapid convergence, unlike what is observed in laboratory experiments using fluids with temperature dependent viscosities. This bimodal strength distribution of the lithosphere distinguishes plate tectonics from simple convection experiments. In addition, Earth has a buoyant, relatively weak layer (the crust) occupying the upper part of the thermal boundary layer. Phase changes lead to extra sources of heat and bouyancy. These phenomena lead to observed richness of behavior of the plate tectonic style of mantle convection.

  14. Ocean forcing drives glacier retreat sometimes

    NASA Astrophysics Data System (ADS)

    Bassis, J. N.; Ultee, E.; Ma, Y.

    2015-12-01

    Observations show that marine-terminating glaciers respond to climate forcing nonlinearly, with periods of slow or negligible glacier advance punctuated by abrupt, rapid retreat. Once glacier retreat has initiated, glaciers can quickly stabilize with a new terminus position. Alternatively, retreat can be sustained for decades (or longer), as is the case for Columbia Glacier, Alaska where retreat initiated ~1984 and continues to this day. Surprisingly, patterns of glacier retreat show ambiguous or even contradictory correlations with atmospheric temperature and glacier surface mass balance. Despite these puzzles, observations increasingly show that intrusion of warm subsurface ocean water into fjords can lead to glacier erosion rates that can account for a substantial portion of the total mass lost from glaciers. Here we use a simplified flowline model to show that even relatively modest submarine melt rates (~100 m/a) near the terminus of grounded glaciers can trigger large increases in iceberg calving leading to rapid glacier retreat. However, the strength of the coupling between submarine melt and calving is a strong function of the geometry of the glacier (bed topography, ice thickness and glacier width). This can lead to irreversible retreat when the terminus is thick and grounded deeply beneath sea level or result in little change when the glacier is relatively thin, grounded in shallow water or pinned in a narrow fjord. Because of the strong dependence on glacier geometry, small perturbations in submarine melting can trigger glaciers in their most advanced—and geometrically precarious—state to undergo sudden retreat followed by much slower re-advance. Although many details remain speculative, our model hints that some glaciers are more sensitive than others to ocean forcing and that some of the nonlinearities of glacier response to climate change may be attributable to variations in difficult-to-detect subsurface water temperatures that need to be better

  15. Comparison of the Unique Mobility and DOE-developed ac electric drive systems

    SciTech Connect

    Cole, G.H.

    1993-01-01

    A comparison was made between the most recent DOE-developed AC electric vehicle drive systems and that which is independently under development by Unique Mobility of Golden, Colorado. The DOE-developed AC systems compared in this study are the Single-Shaft Electric Propulsion System (ETX-II) developed by Ford Motor Company and the General Electric Company under contract number DE-AC07-85NV10418, the Dual-Shaft Electric Propulsion (DSEP) System developed by Eaton Corporation under contract number DOE-AC08-84NV-10366, and the anticipated results of the Modular Electric Vehicle (MEV) system currently being developed by Ford and General Electric under contract number DE-AC07-90ID13019. The Unique Mobility brushless DC electric vehicle drive system represents their latest electric drive technology and is being developed in cooperation with BMW Technik Gmbh of Germany. Comparisons of specific volume, specific weight, efficiency and expected vehicle performance are made of the different systems based upon measured system performance data where available. One conclusion presented is that the Unique Mobility drive system under development with BMW appears to provide comparable performance to the AC systems studied.

  16. ac driving amplitude dependent systematic error in scanning Kelvin probe microscope measurements: Detection and correction

    SciTech Connect

    Wu Yan; Shannon, Mark A.

    2006-04-15

    The dependence of the contact potential difference (CPD) reading on the ac driving amplitude in scanning Kelvin probe microscope (SKPM) hinders researchers from quantifying true material properties. We show theoretically and demonstrate experimentally that an ac driving amplitude dependence in the SKPM measurement can come from a systematic error, and it is common for all tip sample systems as long as there is a nonzero tracking error in the feedback control loop of the instrument. We further propose a methodology to detect and to correct the ac driving amplitude dependent systematic error in SKPM measurements. The true contact potential difference can be found by applying a linear regression to the measured CPD versus one over ac driving amplitude data. Two scenarios are studied: (a) when the surface being scanned by SKPM is not semiconducting and there is an ac driving amplitude dependent systematic error; (b) when a semiconductor surface is probed and asymmetric band bending occurs when the systematic error is present. Experiments are conducted using a commercial SKPM and CPD measurement results of two systems: platinum-iridium/gap/gold and platinum-iridium/gap/thermal oxide/silicon are discussed.

  17. Wall relaxation and the driving forces for cell expansive growth

    NASA Technical Reports Server (NTRS)

    Cosgrove, D. J.

    1987-01-01

    When water uptake by growing cells is prevented, the turgor pressure and the tensile stress in the cell wall are reduced by continued wall loosening. This process, termed in vivo stress relaxation, provides a new way to study the dynamics of wall loosening and to measure the wall yield threshold and the physiological wall extensibility. Stress relaxation experiments indicate that wall stress supplies the mechanical driving force for wall yielding. Cell expansion also requires water absorption. The driving force for water uptake during growth is created by wall relaxation, which lowers the water potential of the expanding cells. New techniques for measuring this driving force show that it is smaller than believed previously; in elongating stems it is only 0.3 to 0.5 bar. This means that the hydraulic resistance of the water transport pathway is small and that rate of cell expansion is controlled primarily by wall loosening and yielding.

  18. Sequential reconstruction of driving-forces from nonlinear nonstationary dynamics

    NASA Astrophysics Data System (ADS)

    Güntürkün, Ulaş

    2010-07-01

    This paper describes a functional analysis-based method for the estimation of driving-forces from nonlinear dynamic systems. The driving-forces account for the perturbation inputs induced by the external environment or the secular variations in the internal variables of the system. The proposed algorithm is applicable to the problems for which there is too little or no prior knowledge to build a rigorous mathematical model of the unknown dynamics. We derive the estimator conditioned on the differentiability of the unknown system’s mapping, and smoothness of the driving-force. The proposed algorithm is an adaptive sequential realization of the blind prediction error method, where the basic idea is to predict the observables, and retrieve the driving-force from the prediction error. Our realization of this idea is embodied by predicting the observables one-step into the future using a bank of echo state networks (ESN) in an online fashion, and then extracting the raw estimates from the prediction error and smoothing these estimates in two adaptive filtering stages. The adaptive nature of the algorithm enables to retrieve both slowly and rapidly varying driving-forces accurately, which are illustrated by simulations. Logistic and Moran-Ricker maps are studied in controlled experiments, exemplifying chaotic state and stochastic measurement models. The algorithm is also applied to the estimation of a driving-force from another nonlinear dynamic system that is stochastic in both state and measurement equations. The results are judged by the posterior Cramer-Rao lower bounds. The method is finally put into test on a real-world application; extracting sun’s magnetic flux from the sunspot time series.

  19. New Technique of AC drive in Tokamak using Permanent Magnets

    NASA Astrophysics Data System (ADS)

    Matteucci, Jackson; Zolfaghari, Ali

    2013-10-01

    This study investigates a new technique of capturing the rotational energy of alternating permanent magnets in order to inductively drive an alternating current in tokamak devices. The use of rotational motion bypasses many of the pitfalls seen in typical inductive and non-inductive current drives. Three specific designs are presented and assessed in the following criteria: the profile of the current generated, the RMS loop voltage generated as compared to the RMS power required to maintain it, the system's feasibility from an engineering perspective. All of the analysis has been done under ideal E&M conditions using the Maxwell 3D program. Preliminary results indicate that it is possible to produce an over 99% purely toroidal current with a RMS d Φ/dt of over 150 Tm2/s, driven by 20 MW or less of rotational power. The proposed mechanism demonstrates several key advantages including an efficient mechanical drive system, the generation of pure toroidal currents, and the potential for a quasi-steady state fusion reactor. The following quantities are presented for various driving frequencies and magnet strengths: plasma current generated, loop voltage, torque and power required. This project has been supported by DOE Funding under the SULI program.

  20. Influence of compression forces on tablets disintegration by AC Biosusceptometry.

    PubMed

    Corá, Luciana A; Fonseca, Paulo R; Américo, Madileine F; Oliveira, Ricardo B; Baffa, Oswaldo; Miranda, José Ricardo A

    2008-05-01

    Analysis of physical phenomena that occurs during tablet disintegration has been studied by several experimental approaches; however none of them satisfactorily describe this process. The aim of this study was to investigate the influence of compression force on the tablets by associating the AC Biosusceptometry with consolidated methods in order to validate the biomagnetic technique as a tool for quality control in pharmaceutical processes. Tablets obtained at five compression levels were submitted to mechanical properties tests. For uncoated tablets, water uptake and disintegration force measurements were performed in order to compare with magnetic data. For coated tablets, magnetic measurements were carried out to establish a relationship between physical parameters of the disintegration process. According to the results, differences between the compression levels were found for water uptake, force development and magnetic area variation measurements. ACB method was able to estimate the disintegration properties as well as the kinetics of disintegration process for uncoated and coated tablets. This study provided a new approach for in vitro investigation and validated this biomagnetic technique as a tool for quality control for pharmaceutical industry. Moreover, using ACB will also be possible to test these parameters in humans allowing to establish an in vitro/in vivo correlation (IVIVC). PMID:18164605

  1. Designing Teaching Facilities: Pedagogy as the Driving Force

    ERIC Educational Resources Information Center

    Stump, Karen H.; Swensen, Jill

    2005-01-01

    Pedagogy, the art and science of teaching, should be the driving force behind the design of any teaching facility. What is taught and how it is taught should determine the size, type, and configuration of educational space. The statement seems obvious, but often miscommunication and ill-considered compromises can divert a capital project from an…

  2. Progress on advanced dc and ac induction drives for electric vehicles

    NASA Technical Reports Server (NTRS)

    Schwartz, H. J.

    1982-01-01

    Progress is reported in the development of complete electric vehicle propulsion systems, and the results of tests on the Road Load Simulator of two such systems representative of advanced dc and ac drive technology are presented. One is the system used in the DOE's ETV-1 integrated test vehicle which consists of a shunt wound dc traction motor under microprocessor control using a transistorized controller. The motor drives the vehicle through a fixed ratio transmission. The second system uses an ac induction motor controlled by transistorized pulse width modulated inverter which drives through a two speed automatically shifted transmission. The inverter and transmission both operate under the control of a microprocessor. The characteristics of these systems are also compared with the propulsion system technology available in vehicles being manufactured at the inception of the DOE program and with an advanced, highly integrated propulsion system upon which technology development was recently initiated.

  3. Pulling together: Tissue-generated forces that drive lumen morphogenesis.

    PubMed

    Navis, Adam; Nelson, Celeste M

    2016-07-01

    Mechanical interactions are essential for bending and shaping tissues during morphogenesis. A common feature of nearly all internal organs is the formation of a tubular network consisting of an epithelium that surrounds a central lumen. Lumen formation during organogenesis requires precisely coordinated mechanical and biochemical interactions. Whereas many genetic regulators of lumen formation have been identified, relatively little is known about the mechanical cues that drive lumen morphogenesis. Lumens can be shaped by a variety of physical behaviors including wrapping a sheet of cells around a hollow core, rearranging cells to expose a lumenal cavity, or elongating a tube via cell migration, though many of the details underlying these movements remain poorly understood. It is essential to define how forces generated by individual cells cooperate to produce the tissue-level forces that drive organogenesis. Transduction of mechanical forces relies on several conserved processes including the contraction of cytoskeletal networks or expansion of lumens through increased fluid pressure. The morphogenetic events that drive lumen formation serve as a model for similar mechanical processes occurring throughout development. To understand how lumenal networks arise, it will be essential to investigate how biochemical and mechanical processes integrate to generate complex structures from comparatively simple interactions. PMID:26778757

  4. Unmanned Turning Force Control Based on the Spindle Drive Characteristics

    NASA Astrophysics Data System (ADS)

    Huh, Kunsoo; Pak, Changho

    While the rough turning process is machining a workpiece at various cutting depth, the feedrate is usually selected based on the maximum depth of cut. Even if this selection can avoid power saturation or tool breakage, it is very conservative compared to the capacity of machine tools and can reduce the productivity significantly. Many adaptive control techniques have been reported that can adjust the feedrate to maintain the constant cutting force. However, these controllers are not very widely used in manufacturing industry because of the limitations in measuring the cutting force signals and selecting the appropriate cutting force level. In this paper, an unmanned turning process control system is proposed based on the spindle drive characteristics. A synthesized cutting force monitor is introduced to estimate the cutting force as accurately as a dynamometer does. The reference cutting force level as well as the feed-rate is selected considering the spindle motor characteristics. Because the cutting process is highly nonlinear, a fuzzy logic controller is applied to maintain the desired cutting force level. The experimental results demonstrate that the proposed system can be easily realized in CNC lathe with requiring little additional hardware.

  5. Drive frequency dependent phase imaging in piezoresponse force microscopy

    SciTech Connect

    Bo Huifeng; Kan Yi; Lu Xiaomei; Liu Yunfei; Peng Song; Wang Xiaofei; Cai Wei; Xue Ruoshi; Zhu Jinsong

    2010-08-15

    The drive frequency dependent piezoresponse (PR) phase signal in near-stoichiometric lithium niobate crystals is studied by piezoresponse force microscopy. It is clearly shown that the local and nonlocal electrostatic forces have a great contribution to the PR phase signal. The significant PR phase difference of the antiparallel domains are observed at the contact resonances, which is related to the electrostatic dominated electromechanical interactions of the cantilever and tip-sample system. Moreover, the modulation voltage induced frequency shift at higher eigenmodes could be attributed to the change of indention force depending on the modulation amplitude with a piezoelectric origin. The PR phase of the silicon wafer is also measured for comparison. It is certificated that the electrostatic interactions are universal in voltage modulated scanning probe microscopy and could be extended to other phase imaging techniques.

  6. A.C. motors for high-performance drives: A design-based comparison

    SciTech Connect

    Vagati, A.; Fratta, A.; Franceschini, G.; Rosso, P.M.

    1995-12-31

    Three AC motors are compared, for application in high-performance controlled drives: induction, brushless and synchronous reluctance motors. Their design is optimized, under common design assumptions. Then, the given stall-torques are compared to each other. In addition, the quadrature reactances are compared, as affecting overload and flux-weakening performances. Last, applicative considerations are given, thus defining the most suitable solution for each field.

  7. Impact assessment of land use planning driving forces on environment

    SciTech Connect

    Chen, Longgao; Yang, Xiaoyan; Chen, Longqian; Li, Long

    2015-11-15

    Land use change may exert a negative impact on environmental quality. A state–impact–state (SIS) model describing a state transform under certain impacts has been integrated into land use planning (LUP) environmental impact assessment (LUPEA). This logical model is intuitive and easy to understand, but the exploration of impact is essential to establish the indicator system and to identify the scope of land use environmental impact when it is applied to a specific region. In this study, we investigated environmental driving forces from land use planning (LUPF), along with the conception, components, scope, and impact of LUPF. This method was illustrated by a case study in Zoucheng, China. Through the results, we concluded that (1) the LUPF on environment are impacts originated from the implementation of LUP on a regional environment, which are characterized by four aspects: magnitude, direction, action point, and its owner; (2) various scopes of LUPF on individual environmental elements based on different standards jointly define the final scope of LUPEA; (3) our case study in Zoucheng demonstrates the practicability of this proposed approach; (4) this method can be embedded into LUPEA with direction, magnitudes, and scopes of the LUPF on individual elements obtained, and the identified indicator system can be directly employed into LUPEA and (5) the assessment helps to identify key indicators and to set up a corresponding strategy to mitigate the negative impact of LUP on the environment, which are two important objectives of strategic environmental assessment (SEA) in LUP. - Highlights: • Environmental driving forces from land use planning (LUPF) are investigated and categorized. • Our method can obtains the direction, magnitudes and scopes of environmental driving forces. • The LUPEA scope is determined by the combination of various scopes of LUPF on individual elements. • LUPF assessment can be embedded into LUPEA. • The method can help to

  8. Design single-motor AC drive for energy savings in centrifugal applications

    SciTech Connect

    Not Available

    1982-06-01

    This article is an evaluation of a single- motor with AC drive that saves energy with increased efficiency and reliability in a wide variety of pump, fan, compressor, and other centrifugal applications. Drives deliver adjustable speed for adjustable flow and will satisfy a number of particular objectives. A principal benefit of the drive is its efficiency. The drives also offer regenerative capability without modification, built-in memory for first-fault indication, and easy troubleshooting with comprehensive self-diagnostics. The drive controls flow in centrifugal applications by adjusting the pumps or fan speed. This provides energy savings over conventional flow control systems. Slip devices, also used to produce variable speed in centrifugal equipment, vary the ''slip'' between the constant-speed motor shaft and the pump or fan shaft. The speed which is not transmitted is dissipated as heat within the slip device itself. The drives are available from stock (100-250 hp) for immediate energy savings on both new and retrofit spplications, with a number of standard features: a remote operator control station provides start-stop and speed selection; acceleration/deceleration are separately adjustable over a range of 2.5 to 35 seconds with 5- to 70-second range available using simple jumper selection; and a coast-to-rest is also available using simple jumper selection. The drive can be operated automatically from an ungrounded 4-20 mA process control signal.

  9. Podosome rings generate forces that drive saltatory osteoclast migration

    PubMed Central

    Hu, Shiqiong; Planus, Emmanuelle; Georgess, Dan; Place, Christophe; Wang, Xianghui; Albiges-Rizo, Corinne; Jurdic, Pierre; Géminard, Jean-Christophe

    2011-01-01

    Podosomes are dynamic, actin-containing adhesion structures that collectively self-organize as rings. In this study, we first show by observing osteoclasts plated on bead-seeded soft substrates that podosome assemblies, such as rings, are involved in tension forces. During the expansion of a podosome ring, substrate displacement is oriented outward, suggesting that podosomal structures push the substrate away. To further elucidate the function of forces generated by podosomes, we analyze osteoclast migration. Determining the centers of mass of the whole cell (G) and of actin (P), we demonstrate that osteoclasts migrate by “jumps” and that the trajectories of G and P are strongly correlated. The velocity of the center of mass as a function of time reveals that osteoclasts rapidly catch up with podosomal structures in a periodic pattern. We conclude that actin dynamics inside the cell are not only correlated with cell migration, but drive it. PMID:21737683

  10. Evaluation of semiconductor devices for Electric and Hybrid Vehicle (EHV) ac-drive applications, volume 1

    NASA Technical Reports Server (NTRS)

    Lee, F. C.; Chen, D. Y.; Jovanovic, M.; Hopkins, D. C.

    1985-01-01

    The results of evaluation of power semiconductor devices for electric hybrid vehicle ac drive applications are summarized. Three types of power devices are evaluated in the effort: high power bipolar or Darlington transistors, power MOSFETs, and asymmetric silicon control rectifiers (ASCR). The Bipolar transistors, including discrete device and Darlington devices, range from 100 A to 400 A and from 400 V to 900 V. These devices are currently used as key switching elements inverters for ac motor drive applications. Power MOSFETs, on the other hand, are much smaller in current rating. For the 400 V device, the current rating is limited to 25 A. For the main drive of an electric vehicle, device paralleling is normally needed to achieve practical power level. For other electric vehicle (EV) related applications such as battery charger circuit, however, MOSFET is advantageous to other devices because of drive circuit simplicity and high frequency capability. Asymmetrical SCR is basically a SCR device and needs commutation circuit for turn off. However, the device poses several advantages, i.e., low conduction drop and low cost.

  11. Traction-drive force transmission for telerobotic joints

    NASA Technical Reports Server (NTRS)

    Kuban, D. P.; Williams, D. M.

    1989-01-01

    The U.S. Space Station Program is providing many technological developments to meet the increasing demands of designing such a facility. One of the key areas of research is that of telerobotics for space station assembly and maintenance. Initial implementation will be teleoperated, but long-term plans call for autonomous robotics. One of the essential components for making this transition successful is the manipulator joints mechanism. Historically, teleoperated manipulators and industrial robotics have had very different mechanisms for force transmission. This is because the design objectives are almost mutually exclusive. A teleoperator must have very low friction and inertia to minimize operator fatigue; backlash and stiffness are of secondary concern. A robot, however, must have minimum backlash, and high stiffness for accurate and rapid positioning. A joint mechanism has yet to be developed that can optimize these divergent performance objectives. A joint mechanism that approaches this optimal performance was developed for NASA Langley, Automation Technology Branch. It is a traction-drive differential that uses variable preload mechanisms. The differential provides compact, dexterous motion range with a torque density similar to geared systems. The traction drive offers high stiffness and zero backlash, for good robotic performance, and the variable loading mechanism (VLM) minimizes the drive-train friction, for improved teleoperation.

  12. The thermodynamic driving force for rafting in superalloys

    SciTech Connect

    Nabarro, F.R.N.; Cress, C.M. |; Kotschy

    1996-08-01

    Eshelby`s energy-momentum tensor is used to provide an analytical expression for the driving force for rafting in the elastic regime in a superalloy with a high volume fraction of {gamma}{prime}. The structure is modelled as a simple cubic array of {gamma}{prime} cubes separated by thin sheets of {gamma}. During rafting, the {gamma}{prime} particles are constrained to remain tetragonal prisms. For tension along a cube axis, the driving force is proportional to the product of the tension {sigma}, the fractional difference {delta} of lattice parameters of {gamma}{prime} and {gamma} and the fractional difference m of their elastic constants c{sub 11} {minus} c{sub 12}. As in the calculation of Pineau for an isolated spheroid, needles are formed when this product {sigma}{delta}m is positive. Two- and three-dimensional systems behave similarly. The initial plastic strain in {gamma} is anelastic and in principle reversible. When the plastic strain exceeds m{delta}, platelets perpendicular to the stress axis are formed if the product {sigma}{delta} is negative.

  13. Instabilities across the isotropic conductivity point in a nematic phenyl benzoate under AC driving.

    PubMed

    Kumar, Pramoda; Patil, Shivaram N; Hiremath, Uma S; Krishnamurthy, K S

    2007-08-01

    We characterize the sequence of bifurcations generated by ac fields in a nematic layer held between unidirectionally rubbed ITO electrodes. The material, which possesses a negative dielectric anisotropy epsilona and an inversion temperature for electrical conductivity anisotropy sigmaa, exhibits a monostable tilted alignment near TIN, the isotropic-nematic point. On cooling, an anchoring transition to the homeotropic configuration occurs close to the underlying smectic phase. The field experiments are performed for (i) negative sigmaa and homeotropic alignment, and (ii) weakly positive sigmaa and nearly homeotropic alignment. Under ac driving, the Freedericksz transition is followed by bifurcation into various patterned states. Among them are the striped states that seem to belong to the dielectric regime and localized hybrid instabilities. Very significantly, the patterned instabilities are not excited by dc fields, indicating their possible gradient flexoelectric origin. The Carr-Helfrich mechanism-based theories that take account of flexoelectric terms can explain the observed electroconvective effects only in part. PMID:17616118

  14. The chemical driving force for rafting in superalloys

    SciTech Connect

    Nabarro, F.R.N. |

    1997-08-15

    Until recently, all theories of the driving force for rafting have considered the compositions of the two phases to be fixed, although accepting that the rate of rafting might be controlled by diffusion. When plastic flow occurs, the difference in elastic constants becomes negligible. A high energy density builds up in the transverse {gamma} sheets, and rafting occurs by outward motion of the transverse interfaces, reducing the volume which has a high energy density. The analysis considers only the change in enthalpy between two states, one in which the two phases have the compositions which are in equilibrium in the absence of external stress, the external stress has been applied, but no diffusion has occurred, and one in which the two phases have the homogeneous compositions which are in equilibrium under the applied stress. The authors do not attempt to treat the intermediate configuration in which some diffusion has occurred, but the compositions of the phases are inhomogeneous.

  15. An adaptive fuzzy controller for permanent-magnet AC servo drives

    SciTech Connect

    Le-Huy, H.

    1995-12-31

    This paper presents a theoretical study on a model-reference adaptive fuzzy logic controller for vector-controlled permanent-magnet ac servo drives. In the proposed system, fuzzy logic is used to implement the direct controller as well as the adaptation mechanism. The operation of the direct fuzzy controller and the fuzzy logic based adaptation mechanism is studied. The control performance of the adaptive fuzzy controller is evaluated by simulation for various operating conditions. The results are compared with that provided by a non-adaptive fuzzy controller. The implementation of proposed adaptive fuzzy controller is discussed.

  16. Fuzzy based power factor improvement strategy for a multiple connected AC-DC converter fed drive

    NASA Astrophysics Data System (ADS)

    Radhakrishnan, N.; Muthiah, Ramaswamy

    2012-01-01

    The main focus of this paper is to design a Fuzzy based control algorithm to realize an improvement in the input power factor of a multiple connected AC-DC converter fed drive system. It incorporates the role of fuzzy inference principles to generate appropriate PWM pulses for the power switches at the second stage of the power module. The philosophy is developed, with a view to reshape the input current phasor and enables it to align with the supply voltage wave in the perspective of improving the input power factor. The closed loop scheme evaluated using MATLAB based simulation exhibits an enhancement in supply power factor over a range of operating loads in addition to illustrating the speed regulating capability of the drive.

  17. Comparison of a synergetic battery pack drive system to a pulse width modulated AC induction motor drive for an electric vehicle

    SciTech Connect

    Davis, A.; Salameh, Z.M.; Eaves, S.S.

    1999-06-01

    A new battery configuration technique and accompanying control circuitry, termed a Synergetic Battery Pack (SBP), is designed to work with Lithium batteries, and can be used as both an inverter for an electric vehicle AC induction motor drive and as a battery charger. In this paper, the performance of a Synergetic Battery Pack during motor drive operation is compared via computer simulation with a conventional motor drive which uses sinusoidal pulse width modulation (SPWM) to determine its effectiveness as a motor drive. The study showed that the drive efficiency was compatible with the conventional system, and offered a significant advantage in the lower frequency operating ranges. The voltage total harmonic distortion (THD) of the SBP was significantly lower than the PWM drive output, but the current THD was slightly higher due to the shape of the harmonic spectrum. In conclusion, the SBP is an effective alternative to a conventional drive, but the real advantage lies in its battery management capabilities and charger operation.

  18. Molecular pathology as the driving force for personalized oncology.

    PubMed

    Oktay, Maja H; Hui, Pei

    2012-11-01

    Innovative Tissue-Based Diagnostics Philadelphia, PA, USA, 4-5 June 2012 This article focuses on the current and emerging molecular diagnostics relevant to clinical practice of oncology discussed in the session of Molecular Pathology as the Driving Force for Personalized Oncology, one of the three main themes of innovative tissue-based diagnostics with the other two being pathology in cancer drug development, and in vivo microscopy and intraoperative imaging. The session brought together seven topics and a keynote presentation in the area of precision cancer diagnosis and treatment: single gene molecular testing as the most popular cancer molecular diagnostics in current time, panel gene mutation analysis as an emerging theme for cancer therapy targeting at multiple signaling pathways, and the next-generation sequencing platform - an ultimate molecular analysis of cancer for future clinical practice. Novel tactics based on existing technology were emphasized including in vitro drug sensitivity testing and exploring immunohistochemistry in combination with histocytological assays for risk assessment of tumor metastasis and layered immunohistochemistry to predict tumor response to target cancer treatment. Clinical molecular assay development, verification and validation were among practical topics in molecular diagnostic operations. The conference was culminated by Marc Ladanyi's keynote presentation of the current and future strategies for comprehensive routine clinical genotyping of lung cancers for optimal selection of targeted therapies. PMID:23249199

  19. Development of a computer algorithm for the analysis of variable-frequency AC drives: Case studies included

    NASA Technical Reports Server (NTRS)

    Kankam, M. David; Benjamin, Owen

    1991-01-01

    The development of computer software for performance prediction and analysis of voltage-fed, variable-frequency AC drives for space power applications is discussed. The AC drives discussed include the pulse width modulated inverter (PWMI), a six-step inverter and the pulse density modulated inverter (PDMI), each individually connected to a wound-rotor induction motor. Various d-q transformation models of the induction motor are incorporated for user-selection of the most applicable model for the intended purpose. Simulation results of selected AC drives correlate satisfactorily with published results. Future additions to the algorithm are indicated. These improvements should enhance the applicability of the computer program to the design and analysis of space power systems.

  20. Self-driving capacitive cantilevers for high-frequency atomic force microscopy

    NASA Astrophysics Data System (ADS)

    Brown, Keith A.; Yang, Benjamin H.; Westervelt, R. M.

    2012-01-01

    We demonstrate a simple way to actuate an atomic force microscope cantilever at high frequencies by electrically driving a thin-film capacitor on its surface. Capacitive driving directly actuates the vibrational mode of the cantilever, removing the effects of unwanted mechanical modes present in conventional driving systems and removing the need for a drive piezoelectric. Practical vibration amplitudes are attainable at drive voltages <5 V. We capacitively drive the first mechanical resonance of a tapping mode cantilever (243 kHz) and a high-frequency cantilever (1.5 MHz) with vibration amplitudes in agreement with our model of capacitive driving.

  1. Traction-drive force transmission for telerobotic joints

    NASA Technical Reports Server (NTRS)

    Williams, D. M.; Kuban, D. P.

    1989-01-01

    A mechanism which meets the requirements of a teleoperated manipulator and those of an autonomous robot is discussed. The mechanism is a traction-drive differential that uses variable preload mechanisms. The differential provides compact design, with dextrous motion range and torque density similar to geared systems. The traction drive offers high stiffness to backlash for good robotic performance. The variable-loading mechanism (VLM) minimizes the drive-train friction for improved teleoperation. This combination provides a mechanism to allow advanced manipulation with either teleoperated control or autonomous robotic operation. The design principles of both major components of the joint mechanism are described.

  2. Cation charge dependence of the forces driving DNA assembly.

    PubMed

    DeRouchey, Jason; Parsegian, V Adrian; Rau, Donald C

    2010-10-20

    Understanding the strength and specificity of interactions among biologically important macromolecules that control cellular functions requires quantitative knowledge of intermolecular forces. Controlled DNA condensation and assembly are particularly critical for biology, with separate repulsive and attractive intermolecular forces determining the extent of DNA compaction. How these forces depend on the charge of the condensing ion has not been determined, but such knowledge is fundamental for understanding the basis of DNA-DNA interactions. Here, we measure DNA force-distance curves for a homologous set of arginine peptides. All forces are well fit as the sum of two exponentials with 2.4- and 4.8-Å decay lengths. The shorter-decay-length force is always repulsive, with an amplitude that varies slightly with length or charge. The longer-decay-length force varies strongly with cation charge, changing from repulsion with Arg¹ to attraction with Arg². Force curves for a series of homologous polyamines and the heterogeneous protein protamine are quite similar, demonstrating the universality of these forces for DNA assembly. Repulsive amplitudes of the shorter-decay-length force are species-dependent but nearly independent of charge within each species. A striking observation was that the attractive force amplitudes for all samples collapse to a single curve, varying linearly with the inverse of the cation charge. PMID:20959102

  3. Nonlinear forced response of electromechanical integrated toroidal drive to coupled excitation.

    PubMed

    Xu, Lizhong; Wang, Fen

    2012-01-01

    The electric excitation and the parameter excitation from mesh stiffness fluctuation are analyzed. The forced response equations of the drive system to the coupled excitations are presented. For the exciting frequencies far from and near natural frequencies, the forced responses of the drive system to the coupled excitations are investigated. Results show that the nonlinear forced responses of the drive system to the coupled excitations change periodically and unsteadily; the time period of the nonlinear forced responses depends on the frequencies of the electric excitation, the mesh parameter excitation, and the nonlinear natural frequencies of the drive system; in order to improve the dynamics performance of the drive system, the frequencies of the electric excitations should not be taken as integral multiple of the mesh parameter exciting frequency. PMID:23251105

  4. Shape of the Hanle curve in spin-transport structures in the presence of an ac drive

    NASA Astrophysics Data System (ADS)

    Roundy, R. C.; Prestgard, M. C.; Tiwari, A.; Raikh, M. E.

    2014-11-01

    Resistance between two ferromagnetic electrodes coupled to a normal channel depends on their relative magnetizations. The spin-dependent component, R , of the resistance changes with magnetic field, B , normal to the directions of magnetizations. In the field of spin transport, this change, R (B ) , originating from the Larmour spin precession, is called the Hanle curve. We demonstrate that the shape of the Hanle curve evolves upon application of an ac drive and study this evolution theoretically as a function of the amplitude, B1, and frequency, ω , of the drive. If the distance between the electrodes, L , is smaller than the spin-diffusion length, λs, the prime effect of a weak circular-polarized drive is the shift of the center of the curve to the value of B for which the Larmour frequency, ωL, is ˜B12/ω . Magnetic resonance at ωL˜ω manifests itself in the derivative, d/R d B . For large L ≫λs the ac drive affects the Hanle curve if the drive amplitude exceeds the spin-relaxation rate, τs-1, i.e., at B1τs≳1 . The prime effect of the drive is the elimination of a minimum in R (B ) . A linearly polarized drive has a fundamentally different effect on the Hanle curve, affecting not its shape but rather its width.

  5. True polar wander and plate-driving forces

    NASA Technical Reports Server (NTRS)

    Davis, D. M.; Solomon, S. C.

    1985-01-01

    The nature of net torques applied to the lithosphere by ridge and trench forces as implied by the absence of recent true polar wander is explored. The 'ridge push' and 'trench pull' forces and the potential net torques on the global lithosphere contributed by each of these forces are discussed. It is shown that the relative magnitudes of the net torques contributed by ridge and trench forces are constrained by the absence of true polar wander during the Cenozoic and by the magnitudes of basal shear stresses on the faster moving plates. It is suggested that the lack of recent true polar wander may be due at least in part to the coincidence of a near cancellation of net torques contributed by ridge and trench forces.

  6. A transputer-based adaptive speed controller for AC induction motor drives with load torque estimation

    SciTech Connect

    Tsai, M.F.; Tzou, Y.Y.

    1997-03-01

    In this paper, the authors design and implement an adaptive speed controller that can estimate load torque for ac induction motor drives employing a transputer-based parallel processing technique. The adaptive speed controller, which precedes the field-oriented control loop, consists of a two-degree-of-freedom controller and a feedforward load-torque compensator. The two-degree-of-freedom controller is designed by a pole-placement technique with polynomial manipulations. Its parameters are adjusted adaptively in terms of estimated model parameters. Estimating the model parameters entails a second-order least-squares estimator with constant trace to avoid estimator windup. The design of the feedforward compensator is based on an estimated load-torque model. Estimating the load torque entails a first-order least-squares estimator with variable forgetting factor and covariance resetting, the purposes of which are to detect any slow or sudden changes of torque disturbance, respectively. The resulting adaptive controller is implemented in parallel by IMS T800-20 transputers. Experimental results demonstrate the robustness of the proposed control method in contending with varying load and torque disturbance.

  7. Self-Motion Depending on the Physicochemical Properties of Esters as the Driving Force

    ERIC Educational Resources Information Center

    Nakata, Satoshi; Matsuo, Kyoko; Kirisaka, Junko

    2007-01-01

    The self-motion of an ester boat is investigated depending on the physicochemical properties of the surface-active substance. The results show that the ester boat moves towards the higher surface tension generating as the driving force.

  8. Analysis of Korean Students' International Mobility by 2-D Model: Driving Force Factor and Directional Factor

    ERIC Educational Resources Information Center

    Park, Elisa L.

    2009-01-01

    The purpose of this study is to understand the dynamics of Korean students' international mobility to study abroad by using the 2-D Model. The first D, "the driving force factor," explains how and what components of the dissatisfaction with domestic higher education perceived by Korean students drives students' outward mobility to seek foreign…

  9. Nano-rheology of hydrogels using direct drive force modulation atomic force microscopy.

    PubMed

    Nalam, Prathima C; Gosvami, Nitya N; Caporizzo, Matthew A; Composto, Russell J; Carpick, Robert W

    2015-11-01

    We present a magnetic force-based direct drive modulation method to measure local nano-rheological properties of soft materials across a broad frequency range (10 Hz to 2 kHz) using colloid-attached atomic force microscope (AFM) probes in liquid. The direct drive method enables artefact-free measurements over several decades of excitation frequency, and avoids the need to evaluate medium-induced hydrodynamic drag effects. The method was applied to measure the local mechanical properties of polyacrylamide hydrogels. The frequency-dependent storage stiffness, loss stiffness, and loss tangent (tan δ) were quantified for hydrogels having high and low crosslinking densities by measuring the amplitude and the phase response of the cantilever while the colloid was in contact with the hydrogel. The frequency bandwidth was further expanded to lower effective frequencies (0.1 Hz to 10 Hz) by obtaining force-displacement (FD) curves. Slow FD measurements showed a recoverable but highly hysteretic response, with the contact mechanical behaviour dependent on the loading direction: approach curves showed Hertzian behaviour while retraction curves fit the JKR contact mechanics model well into the adhesive regime, after which multiple detachment instabilities occurred. Using small amplitude dynamic modulation to explore faster rates, the load dependence of the storage stiffness transitioned from Hertzian to a dynamic punch-type (constant contact area) model, indicating significant influence of material dissipation coupled with adhesion. Using the appropriate contact model across the full frequency range measured, the storage moduli were found to remain nearly constant until an increase began near ∼100 Hz. The softer gels' storage modulus increased from 7.9 ± 0.4 to 14.5 ± 2.1 kPa (∼85%), and the stiffer gels' storage modulus increased from 16.3 ± 1.1 to 31.7 ± 5.0 kPa (∼95%). This increase at high frequencies may be attributed to a contribution from solvent

  10. Axial force and efficiency tests of fixed center variable speed belt drive

    NASA Technical Reports Server (NTRS)

    Bents, D. J.

    1981-01-01

    An investigation of how the axial force varies with the centerline force at different speed ratios, speeds, and loads, and how the drive's transmission efficiency is affected by these related forces is described. The tests, intended to provide a preliminary performance and controls characterization for a variable speed belt drive continuously variable transmission (CVT), consisted of the design and construction of an experimental test rig geometrically similar to the CVT, and operation of that rig at selected speed ratios and power levels. Data are presented which show: how axial forces exerted on the driver and driven sheaves vary with the centerline force at constant values of speed ratio, speed, and output power; how the transmission efficiency varies with centerline force and how it is also a function of the V belt coefficient; and the axial forces on both sheaves as normalized functions of the traction coefficient.

  11. The effect of dissipation on the torque and force experienced by nanoparticles in an AC field

    NASA Astrophysics Data System (ADS)

    Claro, F.; Fuchs, R.; Robles, P.; Rojas, R.

    2015-09-01

    We discuss the force and torque acting on spherical particles in an ensemble in the presence of a uniform AC electric field. We show that for a torque causing particle rotation to appear the particle must be absorptive. Our proof includes all electromagnetic excitations, which in the case of two or more particles gives rise to one or more resonances in the spectrum of force and torque depending on interparticle distance. Several peaks are found in the force and torque between two spheres at small interparticle distances, which coalesce to just one as the separation grows beyond three particle radii. We also show that in the presence of dissipation the force on each particle is nonconservative and may not be derived from the classical interaction potential energy as has been done in the past.

  12. Interaction Forces Drive the Environmental Transmission of Pathogenic Protozoa

    PubMed Central

    Aubert, Dominique; Puech, Pierre-Henri; Hohweyer, Jeanne; Azas, Nadine; Villena, Isabelle

    2012-01-01

    The protozoan parasites Giardia duodenalis, Cryptosporidium spp., and Toxoplasma gondii are pathogens that are resistant to a number of environmental factors and pose significant risks to public health worldwide. Their environmental transmission is closely governed by the physicochemical properties of their cysts (Giardia) and oocysts (Cryptosporidium and Toxoplasma), allowing their transport, retention, and survival for months in water, soil, vegetables, and mollusks, which are the main reservoirs for human infection. Importantly, the cyst/oocyst wall plays a key role in that regard by exhibiting a complex polymeric coverage that determines the charge and hydrophobic characteristics of parasites' surfaces. Interaction forces between parasites and other environmental particles may be, in a first approximation, evaluated following the Derjaguin-Landau-Verwey-Overbeek (DLVO) theory of colloidal stability. However, due to the molecular topography and nano- to microstructure of the cyst/oocyst surface, non-DVLO hydrophobic forces together with additional steric attractive and/or repulsive forces may play a pivotal role in controlling the parasite behavior when the organism is subjected to various external conditions. Here, we review several parameters that enhance or hinder the adhesion of parasites to other particles and surfaces and address the role of fast-emerging techniques for mapping the cyst/oocyst surface, e.g., by measuring its topology and the generated interaction forces at the nano- to microscale. We discuss why characterizing these interactions could be a crucial step for managing the environmental matrices at risk of microbial pollution. PMID:22156429

  13. Drive-amplitude-modulation atomic force microscopy: From vacuum to liquids

    PubMed Central

    Jaafar, Miriam; Cuenca, Mariano; Melcher, John; Raman, Arvind

    2012-01-01

    Summary We introduce drive-amplitude-modulation atomic force microscopy as a dynamic mode with outstanding performance in all environments from vacuum to liquids. As with frequency modulation, the new mode follows a feedback scheme with two nested loops: The first keeps the cantilever oscillation amplitude constant by regulating the driving force, and the second uses the driving force as the feedback variable for topography. Additionally, a phase-locked loop can be used as a parallel feedback allowing separation of the conservative and nonconservative interactions. We describe the basis of this mode and present some examples of its performance in three different environments. Drive-amplutide modulation is a very stable, intuitive and easy to use mode that is free of the feedback instability associated with the noncontact-to-contact transition that occurs in the frequency-modulation mode. PMID:22563531

  14. Nano-rheology of hydrogels using direct drive force modulation atomic force microscopy†

    PubMed Central

    Nalam, Prathima C.; Gosvami, Nitya N.; Caporizzo, Matthew A.; Composto, Russell J.

    2016-01-01

    We present a magnetic force-based direct drive modulation method to measure local nano-rheological properties of soft materials across a broad frequency range (10 Hz to 2 kHz) using colloid-attached atomic force microscope (AFM) probes in liquid. The direct drive method enables artefact-free measurements over several decades of excitation frequency, and avoids the need to evaluate medium-induced hydrodynamic drag effects. The method was applied to measure the local mechanical properties of polyacrylamide hydrogels. The frequency-dependent storage stiffness, loss stiffness, and loss tangent (tan δ) were quantified for hydrogels having high and low crosslinking densities by measuring the amplitude and the phase response of the cantilever while the colloid was in contact with the hydrogel. The frequency bandwidth was further expanded to lower effective frequencies (0.1 Hz to 10 Hz) by obtaining force–displacement (FD) curves. Slow FD measurements showed a recoverable but highly hysteretic response, with the contact mechanical behaviour dependent on the loading direction: approach curves showed Hertzian behaviour while retraction curves fit the JKR contact mechanics model well into the adhesive regime, after which multiple detachment instabilities occurred. Using small amplitude dynamic modulation to explore faster rates, the load dependence of the storage stiffness transitioned from Hertzian to a dynamic punch-type (constant contact area) model, indicating significant influence of material dissipation coupled with adhesion. Using the appropriate contact model across the full frequency range measured, the storage moduli were found to remain nearly constant until an increase began near ∼100 Hz. The softer gels' storage modulus increased from 7.9 ± 0.4 to 14.5 ± 2.1 kPa (∼85%), and the stiffer gels' storage modulus increased from 16.3 ± 1.1 to 31.7 ± 5.0 kPa (∼95%). This increase at high frequencies may be attributed to a contribution from solvent

  15. Cancer metabolism as a central driving force of glioma pathogenesis.

    PubMed

    Masui, Kenta; Cavenee, Webster K; Mischel, Paul S

    2016-07-01

    The recent identification of distinct genetic and epigenetic features in each glioma entity is leading to a multilayered, integrated diagnostic approach combining histologic features with molecular genetic information. Somatic mutations in isocitrate dehydrogenase (IDH) and receptor tyrosine kinase (RTK) pathways are key oncogenic events in diffuse gliomas, including lower grade (grade II and III) gliomas (LGG) and the highly lethal brain tumor glioblastoma (GBM), respectively, where they reprogram the epigenome, transcriptome, and metabolome to drive tumor growth. However, the mechanisms by which these genetic aberrations are translated into the aggressive nature of gliomas through metabolic reprogramming have just begun to be unraveled. The intricate interactions between the oncogenic signaling and cancer metabolism have also been recently demonstrated. Here, we describe a set of recent discoveries on cancer metabolism driven by IDH mutation and mutations in RTK pathways, highlighting the integration of genetic mutations, metabolic reprogramming, and epigenetic shifts, potentially providing new therapeutic opportunities. PMID:27295313

  16. Lifetime of metastable states in a Ginzburg-Landau system: Numerical simulations at large driving forces.

    PubMed

    Umantsev, A

    2016-04-01

    We developed a "brute-force" simulation method and conducted numerical "experiments" on homogeneous nucleation in an isotropic system at large driving forces (not small supersaturations) using the stochastic Ginzburg-Landau approach. Interactions in the system are described by the asymmetric (no external field), athermal (temperature-independent driving force), tangential (simple phase diagram) Hamiltonian, which has two independent "drivers" of the phase transition: supersaturation and thermal noise. We obtained the probability distribution function of the lifetime of the metastable state and analyzed its mean value as a function of the supersaturation, noise strength, and volume. We also proved the nucleation theorem in the mean-field approximation. The results allowed us to find the thermodynamic properties of the barrier state and conclude that at large driving forces the fluctuating volumes are not independent. PMID:27176373

  17. Transport and efficiency of Brownian particles in confined narrow channels with a periodic driving force

    NASA Astrophysics Data System (ADS)

    Wang, Rang; Zhou, Jia-Ning; Liu, Xue-Mei; Xiao, Hua

    2015-11-01

    Transport and efficiency of over-damped Brownian particles moving in a confined narrow channel is investigated in the presence of an oscillating force and a static load force. It is found that the average velocity increases monotonously with the unbiased external driving force, while the efficiency can be a peaked function of unbiased external force, which indicates that the unbiased external force can facilitate the efficiency of energy transformation. Moreover, the average velocity and the efficiency demonstrate complex behaviors due to the consideration of Stokes efficiency.

  18. Position and force control of a vehicle with two or more steerable drive wheels

    SciTech Connect

    Reister, D.B.; Unseren, M.A.

    1992-10-01

    When a vehicle with two or more steerable drive wheels is traveling in a circle, the motion of the wheels is constrained. The wheel translational velocity divided by the radius to the center of rotation must be the same for all wheels. When the drive wheels are controlled independently using position control, the motion of the wheels may violate the constraints and the wheels may slip. Consequently, substantial errors can occur in the orientation of the vehicle. A vehicle with N drive wheels has (N - 1) constraints and one degree of freedom. We have developed a new approach to the control of a vehicle with N steerable drive wheels. The novel aspect of our approach is the use of force control. To control the vehicle, we have one degree of freedom for the position on the circle and (N - 1) forces that can be used to reduce errors. Recently, Kankaanranta and Koivo developed a control architecture that allows the force and position degrees of freedom to be decoupled. In the work of Kankaanranta and Koivo the force is an exogenous input. We have made the force endogenous by defining the force in terms of the errors in satisfying the rigid body kinematic constraints. We have applied the control architecture to the HERMIES-III robot and have measured a dramatic reduction in error (more than a factor of 20) compared to motions without force control.

  19. Amplitude modulation atomic force microscopy, is acoustic driving in liquid quantitatively reliable?

    PubMed

    Liu, Fei; Zhao, Cunlu; Mugele, Frieder; van den Ende, Dirk

    2015-09-25

    Measuring quantitative tip-sample interaction forces in dynamic atomic force microscopy in fluids is challenging because of the strong damping of the ambient viscous medium and the fluid-mediated driving forces. This holds in particular for the commonly used acoustic excitation of the cantilever oscillation. Here we present measurements of tip-sample interactions due to conservative DLVO and hydration forces and viscous dissipation forces in aqueous electrolytes using tips with radii varying from typical 20 nm for the DLVO and hydration forces, to 1 μm for the viscous dissipation. The measurements are analyzed using a simple harmonic oscillator model, continuous beam theory with fluid-mediated excitation and thermal noise spectroscopy (TNS). In all cases consistent conservative forces, deviating less than 40% from each other, are obtained for all three approaches. The DLVO forces are even within 5% of the theoretical expectations for all approaches. Accurate measurements of dissipative forces within 15% of the predictions of macroscopic fluid dynamics require the use of TNS or continuous beam theory including fluid-mediated driving. Taking this into account, acoustic driving in liquid is quantitatively reliable. PMID:26335613

  20. Amplitude modulation atomic force microscopy, is acoustic driving in liquid quantitatively reliable?

    NASA Astrophysics Data System (ADS)

    Liu, Fei; Zhao, Cunlu; Mugele, Frieder; van den Ende, Dirk

    2015-09-01

    Measuring quantitative tip-sample interaction forces in dynamic atomic force microscopy in fluids is challenging because of the strong damping of the ambient viscous medium and the fluid-mediated driving forces. This holds in particular for the commonly used acoustic excitation of the cantilever oscillation. Here we present measurements of tip-sample interactions due to conservative DLVO and hydration forces and viscous dissipation forces in aqueous electrolytes using tips with radii varying from typical 20 nm for the DLVO and hydration forces, to 1 μm for the viscous dissipation. The measurements are analyzed using a simple harmonic oscillator model, continuous beam theory with fluid-mediated excitation and thermal noise spectroscopy (TNS). In all cases consistent conservative forces, deviating less than 40% from each other, are obtained for all three approaches. The DLVO forces are even within 5% of the theoretical expectations for all approaches. Accurate measurements of dissipative forces within 15% of the predictions of macroscopic fluid dynamics require the use of TNS or continuous beam theory including fluid-mediated driving. Taking this into account, acoustic driving in liquid is quantitatively reliable.

  1. Experimental modeling of the effect of hurricane wind forces on driving behavior and vehicle performance.

    PubMed

    Rodriguez, Jose M; Codjoe, Julius; Osman, Osama; Ishak, Sherif; Wolshon, Brian

    2015-01-01

    While traffic planning is important for developing a hurricane evacuation plan, vehicle performance on the roads during extreme weather conditions is critical to the success of the planning process. This novel study investigates the effect of gusty hurricane wind forces on the driving behavior and vehicle performance. The study explores how the parameters of a driving simulator could be modified to reproduce wind loadings experienced by three vehicle types (passenger car, ambulance, and bus) during gusty hurricane winds, through manipulation of appropriate software. Thirty participants were then tested on the modified driving simulator under five wind conditions (ranging from normal to hurricane category 4). The driving performance measures used were heading error and lateral displacement. The results showed that higher wind forces resulted in more varied and greater heading error and lateral displacement. The ambulance had the greatest heading errors and lateral displacements, which were attributed to its large lateral surface area and light weight. Two mathematical models were developed to estimate the heading error and lateral displacements for each of the vehicle types for a given change in lateral wind force. Through a questionnaire, participants felt the different characteristics while driving each vehicle type. The findings of this study demonstrate the valuable use of a driving simulator to model the behavior of different vehicle types and to develop mathematical models to estimate and quantify driving behavior and vehicle performance under hurricane wind conditions. PMID:25902298

  2. Crack Driving Forces in a Multilayered Coating System for Ceramic Matrix Composite Substrates

    NASA Technical Reports Server (NTRS)

    Ghosn, Louis J.; Zhu, Dongming; Miller, Robert A.

    2005-01-01

    The effects of the top coating thickness, modulus and shrinkage strains on the crack driving forces for a baseline multilayer Yttria-Stabilized-Zirconia/Mullite/Si thermal and environment barrier coating (TEBC) system for SiC/SiC ceramic matrix composite substrates are determined for gas turbine applications. The crack driving forces increase with increasing modulus, and a low modulus thermal barrier coating material (below 10 GPa) will have no cracking issues under the thermal gradient condition analyzed. Since top coating sintering increases the crack driving forces with time, highly sintering resistant coatings are desirable to maintain a low tensile modulus and maintain a low crack driving force with time. Finite element results demonstrated that an advanced TEBC system, such as ZrO2/HfO2, which possesses improved sintering resistance and high temperature stability, exhibited excellent durability. A multi-vertical cracked structure with fine columnar spacing is an ideal strain tolerant coating capable of reducing the crack driving forces to an acceptable level even with a high modulus of 50 GPa.

  3. Modeling of a High Force Density Fishbone Shaped Electrostatic Comb Drive Microactuator

    PubMed Central

    Megat Hasnan, Megat Muhammad Ikhsan; Mohd Sabri, Mohd Faizul; Mohd Said, Suhana; Nik Ghazali, Nik Nazri

    2014-01-01

    This paper presents the design and evaluation of a high force density fishbone shaped electrostatic comb drive actuator. This comb drive actuator has a branched structure similar to a fishbone, which is intended to increase the capacitance of the electrodes and hence increase the electrostatic actuation force. Two-dimensional finite element analysis was used to simulate the motion of the fishbone shaped electrostatic comb drive actuator and compared against the performance of a straight sided electrostatic comb drive actuator. Performances of both designs are evaluated by comparison of displacement and electrostatic force. For both cases, the active area and the minimum gap distance between the two electrodes were constant. An active area of 800 × 300 μm, which contained 16 fingers of fishbone shaped actuators and 40 fingers of straight sided actuators, respectively, was used. Through simulation, improvement of drive force of the fishbone shaped electrostatic comb driver is approximately 485% higher than conventional electrostatic comb driver. These results indicate that the fishbone actuator design provides good potential for applications as high force density electrostatic microactuator in MEMS systems. PMID:25165751

  4. Characterizing a sustainability transition: Goals, targets, trends, and driving forces

    PubMed Central

    Parris, Thomas M.; Kates, Robert W.

    2003-01-01

    Sustainable development exhibits broad political appeal but has proven difficult to define in precise terms. Recent scholarship has focused on the nature of a sustainability transition, described by the National Research Council as meeting the needs of a stabilizing future world population while reducing hunger and poverty and maintaining the planet's life-support systems. We identify a small set of goals, quantitative targets, and associated indicators that further characterize a sustainability transition by drawing on the consensus embodied in internationally negotiated agreements and plans of action. To illustrate opportunities for accelerating progress, we then examine current scholarship on the processes that influence attainment of four such goals: reducing hunger, promoting literacy, stabilizing greenhouse-gas concentrations, and maintaining fresh-water availability. We find that such analysis can often reveal “levers of change,” forces that both control the rate of positive change and are subject to policy intervention. PMID:12819346

  5. Solar Radiation as Driving Force In Early Evolution

    NASA Technical Reports Server (NTRS)

    Rothschild, Lynn J.; Peterson, David L. (Technical Monitor)

    2002-01-01

    Ultraviolet radiation (UVR) has provided an evolutionary challenge to life on Earth in that it is both an agent of mutation and as well as a selective force. Today surface fluxes of UVR vary diurnally, seasonally, etc. Still, the UVR flux was probably substantially higher during the early phases of evolution, suggesting that its role in evolution was even more prominent during this time. In this presentation, the creative role of UVR in evolution is discussed, specifically in connection with the role that UVR may have played in the evolution of early microbial ecosystems. The presentation will include discussions of the direct influence of UVR on such processes as photosynthesis and genetic damage, as well as the indirect influence of UVR as mediated through the production of reactive oxygen species. These biological effects of UVR will be viewed against the backdrop of the physical nature of the early Earth, surely a very different place then than now.

  6. Estimation of the driving force for dioxygen formation in photosynthesis.

    PubMed

    Nilsson, Håkan; Cournac, Laurent; Rappaport, Fabrice; Messinger, Johannes; Lavergne, Jérôme

    2016-01-01

    Photosynthetic water oxidation to molecular oxygen is carried out by photosystem II (PSII) over a reaction cycle involving four photochemical steps that drive the oxygen-evolving complex through five redox states Si (i = 0,…, 4). For understanding the catalytic strategy of biological water oxidation it is important to elucidate the energetic landscape of PSII and in particular that of the final S4 → S0 transition. In this short-lived chemical step the four oxidizing equivalents accumulated in the preceding photochemical events are used up to form molecular oxygen, two protons are released and at least one substrate water molecule binds to the Mn4CaO5 cluster. In this study we probed the probability to form S4 from S0 and O2 by incubating YD-less PSII in the S0 state for 2–3 days in the presence of (18)O2 and H2(16)O. The absence of any measurable (16,18)O2 formation by water-exchange in the S4 state suggests that the S4 state is hardly ever populated. On the basis of a detailed analysis we determined that the equilibrium constant K of the S4 → S0 transition is larger than 1.0 × 10(7) so that this step is highly exergonic. We argue that this finding is consistent with current knowledge of the energetics of the S0 to S4 reactions, and that the high exergonicity is required for the kinetic efficiency of PSII. PMID:26435390

  7. Hypoxia: The Force that Drives Chronic Kidney Disease

    PubMed Central

    Fu, Qiangwei; Colgan, Sean P; Shelley, Carl Simon

    2016-01-01

    In the United States the prevalence of end-stage renal disease (ESRD) reached epidemic proportions in 2012 with over 600,000 patients being treated. The rates of ESRD among the elderly are disproportionally high. Consequently, as life expectancy increases and the baby-boom generation reaches retirement age, the already heavy burden imposed by ESRD on the US health care system is set to increase dramatically. ESRD represents the terminal stage of chronic kidney disease (CKD). A large body of evidence indicating that CKD is driven by renal tissue hypoxia has led to the development of therapeutic strategies that increase kidney oxygenation and the contention that chronic hypoxia is the final common pathway to end-stage renal failure. Numerous studies have demonstrated that one of the most potent means by which hypoxic conditions within the kidney produce CKD is by inducing a sustained inflammatory attack by infiltrating leukocytes. Indispensable to this attack is the acquisition by leukocytes of an adhesive phenotype. It was thought that this process resulted exclusively from leukocytes responding to cytokines released from ischemic renal endothelium. However, recently it has been demonstrated that leukocytes also become activated independent of the hypoxic response of endothelial cells. It was found that this endothelium-independent mechanism involves leukocytes directly sensing hypoxia and responding by transcriptional induction of the genes that encode the β2-integrin family of adhesion molecules. This induction likely maintains the long-term inflammation by which hypoxia drives the pathogenesis of CKD. Consequently, targeting these transcriptional mechanisms would appear to represent a promising new therapeutic strategy. PMID:26847481

  8. Hypoxia: The Force that Drives Chronic Kidney Disease.

    PubMed

    Fu, Qiangwei; Colgan, Sean P; Shelley, Carl Simon

    2016-03-01

    In the United States the prevalence of end-stage renal disease (ESRD) reached epidemic proportions in 2012 with over 600,000 patients being treated. The rates of ESRD among the elderly are disproportionally high. Consequently, as life expectancy increases and the baby-boom generation reaches retirement age, the already heavy burden imposed by ESRD on the US health care system is set to increase dramatically. ESRD represents the terminal stage of chronic kidney disease (CKD). A large body of evidence indicating that CKD is driven by renal tissue hypoxia has led to the development of therapeutic strategies that increase kidney oxygenation and the contention that chronic hypoxia is the final common pathway to end-stage renal failure. Numerous studies have demonstrated that one of the most potent means by which hypoxic conditions within the kidney produce CKD is by inducing a sustained inflammatory attack by infiltrating leukocytes. Indispensable to this attack is the acquisition by leukocytes of an adhesive phenotype. It was thought that this process resulted exclusively from leukocytes responding to cytokines released from ischemic renal endothelium. However, recently it has been demonstrated that leukocytes also become activated independent of the hypoxic response of endothelial cells. It was found that this endothelium-independent mechanism involves leukocytes directly sensing hypoxia and responding by transcriptional induction of the genes that encode the β2-integrin family of adhesion molecules. This induction likely maintains the long-term inflammation by which hypoxia drives the pathogenesis of CKD. Consequently, targeting these transcriptional mechanisms would appear to represent a promising new therapeutic strategy. PMID:26847481

  9. Force control compensation method with variable load stiffness and damping of the hydraulic drive unit force control system

    NASA Astrophysics Data System (ADS)

    Kong, Xiangdong; Ba, Kaixian; Yu, Bin; Cao, Yuan; Zhu, Qixin; Zhao, Hualong

    2016-05-01

    Each joint of hydraulic drive quadruped robot is driven by the hydraulic drive unit (HDU), and the contacting between the robot foot end and the ground is complex and variable, which increases the difficulty of force control inevitably. In the recent years, although many scholars researched some control methods such as disturbance rejection control, parameter self-adaptive control, impedance control and so on, to improve the force control performance of HDU, the robustness of the force control still needs improving. Therefore, how to simulate the complex and variable load characteristics of the environment structure and how to ensure HDU having excellent force control performance with the complex and variable load characteristics are key issues to be solved in this paper. The force control system mathematic model of HDU is established by the mechanism modeling method, and the theoretical models of a novel force control compensation method and a load characteristics simulation method under different environment structures are derived, considering the dynamic characteristics of the load stiffness and the load damping under different environment structures. Then, simulation effects of the variable load stiffness and load damping under the step and sinusoidal load force are analyzed experimentally on the HDU force control performance test platform, which provides the foundation for the force control compensation experiment research. In addition, the optimized PID control parameters are designed to make the HDU have better force control performance with suitable load stiffness and load damping, under which the force control compensation method is introduced, and the robustness of the force control system with several constant load characteristics and the variable load characteristics respectively are comparatively analyzed by experiment. The research results indicate that if the load characteristics are known, the force control compensation method presented in this

  10. Force control compensation method with variable load stiffness and damping of the hydraulic drive unit force control system

    NASA Astrophysics Data System (ADS)

    Kong, Xiangdong; Ba, Kaixian; Yu, Bin; Cao, Yuan; Zhu, Qixin; Zhao, Hualong

    2016-04-01

    Each joint of hydraulic drive quadruped robot is driven by the hydraulic drive unit (HDU), and the contacting between the robot foot end and the ground is complex and variable, which increases the difficulty of force control inevitably. In the recent years, although many scholars researched some control methods such as disturbance rejection control, parameter self-adaptive control, impedance control and so on, to improve the force control performance of HDU, the robustness of the force control still needs improving. Therefore, how to simulate the complex and variable load characteristics of the environment structure and how to ensure HDU having excellent force control performance with the complex and variable load characteristics are key issues to be solved in this paper. The force control system mathematic model of HDU is established by the mechanism modeling method, and the theoretical models of a novel force control compensation method and a load characteristics simulation method under different environment structures are derived, considering the dynamic characteristics of the load stiffness and the load damping under different environment structures. Then, simulation effects of the variable load stiffness and load damping under the step and sinusoidal load force are analyzed experimentally on the HDU force control performance test platform, which provides the foundation for the force control compensation experiment research. In addition, the optimized PID control parameters are designed to make the HDU have better force control performance with suitable load stiffness and load damping, under which the force control compensation method is introduced, and the robustness of the force control system with several constant load characteristics and the variable load characteristics respectively are comparatively analyzed by experiment. The research results indicate that if the load characteristics are known, the force control compensation method presented in this

  11. Intracellular and extracellular forces drive primary cilia movement.

    PubMed

    Battle, Christopher; Ott, Carolyn M; Burnette, Dylan T; Lippincott-Schwartz, Jennifer; Schmidt, Christoph F

    2015-02-01

    Primary cilia are ubiquitous, microtubule-based organelles that play diverse roles in sensory transduction in many eukaryotic cells. They interrogate the cellular environment through chemosensing, osmosensing, and mechanosensing using receptors and ion channels in the ciliary membrane. Little is known about the mechanical and structural properties of the cilium and how these properties contribute to ciliary perception. We probed the mechanical responses of primary cilia from kidney epithelial cells [Madin-Darby canine kidney-II (MDCK-II)], which sense fluid flow in renal ducts. We found that, on manipulation with an optical trap, cilia deflect by bending along their length and pivoting around an effective hinge located below the basal body. The calculated bending rigidity indicates weak microtubule doublet coupling. Primary cilia of MDCK cells lack interdoublet dynein motors. Nevertheless, we found that the organelles display active motility. 3D tracking showed correlated fluctuations of the cilium and basal body. These angular movements seemed random but were dependent on ATP and cytoplasmic myosin-II in the cell cortex. We conclude that force generation by the actin cytoskeleton surrounding the basal body results in active ciliary movement. We speculate that actin-driven ciliary movement might tune and calibrate ciliary sensory functions. PMID:25605896

  12. Intracellular and extracellular forces drive primary cilia movement

    PubMed Central

    Battle, Christopher; Ott, Carolyn M.; Burnette, Dylan T.; Lippincott-Schwartz, Jennifer; Schmidt, Christoph F.

    2015-01-01

    Primary cilia are ubiquitous, microtubule-based organelles that play diverse roles in sensory transduction in many eukaryotic cells. They interrogate the cellular environment through chemosensing, osmosensing, and mechanosensing using receptors and ion channels in the ciliary membrane. Little is known about the mechanical and structural properties of the cilium and how these properties contribute to ciliary perception. We probed the mechanical responses of primary cilia from kidney epithelial cells [Madin–Darby canine kidney-II (MDCK-II)], which sense fluid flow in renal ducts. We found that, on manipulation with an optical trap, cilia deflect by bending along their length and pivoting around an effective hinge located below the basal body. The calculated bending rigidity indicates weak microtubule doublet coupling. Primary cilia of MDCK cells lack interdoublet dynein motors. Nevertheless, we found that the organelles display active motility. 3D tracking showed correlated fluctuations of the cilium and basal body. These angular movements seemed random but were dependent on ATP and cytoplasmic myosin-II in the cell cortex. We conclude that force generation by the actin cytoskeleton surrounding the basal body results in active ciliary movement. We speculate that actin-driven ciliary movement might tune and calibrate ciliary sensory functions. PMID:25605896

  13. Tuning the driving force for exciton dissociation in single-walled carbon nanotube heterojunctions

    NASA Astrophysics Data System (ADS)

    Ihly, Rachelle; Mistry, Kevin S.; Ferguson, Andrew J.; Clikeman, Tyler T.; Larson, Bryon W.; Reid, Obadiah; Boltalina, Olga V.; Strauss, Steven H.; Rumbles, Garry; Blackburn, Jeffrey L.

    2016-06-01

    Understanding the kinetics and energetics of interfacial electron transfer in molecular systems is crucial for the development of a broad array of technologies, including photovoltaics, solar fuel systems and energy storage. The Marcus formulation for electron transfer relates the thermodynamic driving force and reorganization energy for charge transfer between a given donor/acceptor pair to the kinetics and yield of electron transfer. Here we investigated the influence of the thermodynamic driving force for photoinduced electron transfer (PET) between single-walled carbon nanotubes (SWCNTs) and fullerene derivatives by employing time-resolved microwave conductivity as a sensitive probe of interfacial exciton dissociation. For the first time, we observed the Marcus inverted region (in which driving force exceeds reorganization energy) and quantified the reorganization energy for PET for a model SWCNT/acceptor system. The small reorganization energies (about 130 meV, most of which probably arises from the fullerene acceptors) are beneficial in minimizing energy loss in photoconversion schemes.

  14. Extracting the driving force from ozone data using slow feature analysis

    NASA Astrophysics Data System (ADS)

    Wang, Geli; Yang, Peicai; Zhou, Xiuji

    2016-05-01

    Slow feature analysis (SFA) is a recommended technique for extracting slowly varying features from a quickly varying signal. In this work, we apply SFA to total ozone data from Arosa, Switzerland. The results show that the signal of volcanic eruptions can be found in the driving force, and wavelet analysis of this driving force shows that there are two main dominant scales, which may be connected with the effect of climate mode such as North Atlantic Oscillation (NAO) and solar activity. The findings of this study represent a contribution to our understanding of the causality from observed climate data.

  15. Thrust and normal force characteristics analysis of linear synchronous motor for direct drive conveyer

    NASA Astrophysics Data System (ADS)

    Zhu, Yu-wu; Kim, Do-sun; Cho, Yun-hyun

    2007-12-01

    The problem in improving the high positioning precision of permanent magnet linear synchronous motor (PMLSM) for direct drive conveyer is the large detent force, which contains two components: one is the cogging force caused by the interaction between the permanent magnet (PM) and the iron core, the other is the end effect caused by the finite mover length. In this paper a force compensator in the field oriented control (FOC) algorithm is employed to reduce this detent force, so the thrust and the normal force characteristics analysis of PMLSM are of the most importance. First the characteristics of the thrust and the normal force are simulated by finite element method (FEM), and the relation of the thrust and the normal force to the q-axis current is analyzed. Then the components of detent force are defined by Fourier series using the curve fitting method, and compensated by injecting the instantaneous currents using the FOC method. Finally the dynamic characteristics of this PMLSM for direct drive conveyer are investigated, and the numerical results are reported to validate the effectiveness of this proposed method.

  16. Visualization of polar nanoregions in lead-free relaxors via piezoresponse force microscopy in torsional dual AC resonance tracking mode

    NASA Astrophysics Data System (ADS)

    Liu, Na; Dittmer, Robert; Stark, Robert W.; Dietz, Christian

    2015-07-01

    Polar nanoregions (PNRs) play a key role in the functionality of relaxor ferroelectrics; however, visualizing them in lead-free relaxor ferroelectrics with high lateral resolution is still challenging. Thus, we studied herein the local ferroelectric domain distribution of the lead-free bismuth-based (1 - x)(Bi1/2Na1/2TiO3-Bi1/2K1/2TiO3) - x(Bi1/2Mg1/2TiO3) piezoceramics which show a relaxor behavior using dual AC resonance tracking (DART) piezoresponse force microscopy (PFM). By using excitation frequencies at either side of the contact resonance peak of the torsional cantilever vibration, an enhanced contrast in the amplitude and phase images of the piezoresponse can be achieved. Additionally, this tracking technique reduces the topographical crosstalk while mapping the local electromechanical properties. The true drive amplitude, drive phase, contact resonant frequency and quality factor can be estimated from DART-PFM data obtained with vertically or torsionally vibrating cantilevers. This procedure yields a three-dimensional quantitative map of the local piezoelectric properties of the relaxor ferroelectric samples. With this approach, torsional DART allowed for the visualization of fine substructures within the monodomains, suggesting the existence of PNRs in relaxor ferroelectrics. The domain structures of the PNRs were visualized with high precision, and the local electromechanical characteristics of the lead-free relaxor ferroelectrics were quantitatively mapped.Polar nanoregions (PNRs) play a key role in the functionality of relaxor ferroelectrics; however, visualizing them in lead-free relaxor ferroelectrics with high lateral resolution is still challenging. Thus, we studied herein the local ferroelectric domain distribution of the lead-free bismuth-based (1 - x)(Bi1/2Na1/2TiO3-Bi1/2K1/2TiO3) - x(Bi1/2Mg1/2TiO3) piezoceramics which show a relaxor behavior using dual AC resonance tracking (DART) piezoresponse force microscopy (PFM). By using excitation

  17. Sustainment of Fine Particle Cloud by Means of Time-Averaged Particle Driving Force in Plasmas

    SciTech Connect

    Gohda, Takuma; Iizuka, Satoru

    2008-09-07

    We have succeeded in sustaining fine particle cloud by using a time-averaged particle driving (TAPD) method in the RF discharge plasma. The particles feel only time-averaged force when the period of pulses applied to those point-electrodes is shorter than the particle response time. The particles are transported to a middle point between two point-electrodes.

  18. Fast charge separation in a non-fullerene organic solar cell with a small driving force

    NASA Astrophysics Data System (ADS)

    Liu, Jing; Chen, Shangshang; Qian, Deping; Gautam, Bhoj; Yang, Guofang; Zhao, Jingbo; Bergqvist, Jonas; Zhang, Fengling; Ma, Wei; Ade, Harald; Inganäs, Olle; Gundogdu, Kenan; Gao, Feng; Yan, He

    2016-07-01

    Fast and efficient charge separation is essential to achieve high power conversion efficiency in organic solar cells (OSCs). In state-of-the-art OSCs, this is usually achieved by a significant driving force, defined as the offset between the bandgap (Egap) of the donor/acceptor materials and the energy of the charge transfer (CT) state (ECT), which is typically greater than 0.3 eV. The large driving force causes a relatively large voltage loss that hinders performance. Here, we report non-fullerene OSCs that exhibit ultrafast and efficient charge separation despite a negligible driving force, as ECT is nearly identical to Egap. Moreover, the small driving force is found to have minimal detrimental effects on charge transfer dynamics of the OSCs. We demonstrate a non-fullerene OSC with 9.5% efficiency and nearly 90% internal quantum efficiency despite a low voltage loss of 0.61 V. This creates a path towards highly efficient OSCs with a low voltage loss.

  19. Design considerations of electromagnetic force in a direct drive permanent magnet brushless motor

    NASA Astrophysics Data System (ADS)

    Chen, H. S.; Tsai, M. C.

    2008-04-01

    In this paper, a numerical study of electromagnetic force associated with the width of stator teeth, width of rotor back iron, and slot opening for a ten-pole nine-slot direct drive permanent magnet brushless motor is presented. The study calculates the amplitude of the electromagnetic force on the rotating rotor by using the finite-element method. The results show that the amplitude of electromagnetic force, which may cause the noise and vibration of motors, changes with the variation of these above mentioned three factors. The relationship between the considerations of output torque and the minimization of noise and vibration is also established in this paper.

  20. Driving Force.

    ERIC Educational Resources Information Center

    Rich, Richard A.

    1998-01-01

    Discusses campus parking assessment and planning to meet the increasing demands of colleges and universities while controlling costs and reducing student and staff discontent. Explores advice for expanding parking-lot space and maintaining security. Provides a chart that shows general parking requirements for various groups based on students…

  1. Vehicle Dynamics Control of In-wheel Electric Motor Drive Vehicles Based on Averaging of Tire Force Usage

    NASA Astrophysics Data System (ADS)

    Masaki, Nobuo; Iwano, Haruo; Kamada, Takayoshi; Nagai, Masao

    For in-wheel electric motor drive vehicles, a new vehicle dynamics control which is based on the tire force usage rate is proposed. The new controller adopts non-linear optimal control could manage the interference between direct yaw-moment control and the tire force usage rate. The new control is considered total longitudinal and transverse tire force. Therefore the controller can prevent tire force saturation near tire force limit during cornering. Simulations and test runs by the custom made four wheel drive in-wheel motor electric vehicle show that higher driving stability performance compared to the performance of the same vehicle without control.

  2. Analyzing the Long Term Cohesive Effect of Sector Specific Driving Forces.

    PubMed

    Berman, Yonatan; Ben-Jacob, Eshel; Zhang, Xin; Shapira, Yoash

    2016-01-01

    Financial markets are partially composed of sectors dominated by external driving forces, such as commodity prices, infrastructure and other indices. We characterize the statistical properties of such sectors and present a novel model for the coupling of the stock prices and their dominating driving forces, inspired by mean reverting stochastic processes. Using the model we were able to explain the market sectors' long term behavior and estimate the coupling strength between stocks in financial markets and the sector specific driving forces. Notably, the analysis was successfully applied to the shipping market, in which the Baltic dry index (BDI), an assessment of the price of transporting the major raw materials by sea, influences the shipping financial market. We also present the analysis of other sectors-the gold mining market and the food production market, for which the model was also successfully applied. The model can serve as a general tool for characterizing the coupling between external forces and affected financial variables and therefore for estimating the risk in sectors and their vulnerability to external stress. PMID:27031230

  3. Analyzing the Long Term Cohesive Effect of Sector Specific Driving Forces

    PubMed Central

    Berman, Yonatan; Zhang, Xin; Shapira, Yoash

    2016-01-01

    Financial markets are partially composed of sectors dominated by external driving forces, such as commodity prices, infrastructure and other indices. We characterize the statistical properties of such sectors and present a novel model for the coupling of the stock prices and their dominating driving forces, inspired by mean reverting stochastic processes. Using the model we were able to explain the market sectors’ long term behavior and estimate the coupling strength between stocks in financial markets and the sector specific driving forces. Notably, the analysis was successfully applied to the shipping market, in which the Baltic dry index (BDI), an assessment of the price of transporting the major raw materials by sea, influences the shipping financial market. We also present the analysis of other sectors—the gold mining market and the food production market, for which the model was also successfully applied. The model can serve as a general tool for characterizing the coupling between external forces and affected financial variables and therefore for estimating the risk in sectors and their vulnerability to external stress. PMID:27031230

  4. A Study of the Effect of the Fringe Fields on the Electrostatic Force in Vertical Comb Drives

    PubMed Central

    Gallagher, Else; Moussa, Walied

    2014-01-01

    The equation that describes the relationship between the applied voltage and the resulting electrostatic force within comb drives is often used to assist in choosing the dimensions for their design. This paper re-examines how some of these dimensions—particularly the cross-sectional dimensions of the comb teeth—affect this relationship in vertical comb drives. The electrostatic forces in several vertical comb drives fabricated for this study were measured and compared to predictions made with four different mathematical models in order to explore the amount of complexity required within a model to accurately predict the electrostatic forces in the comb drives. PMID:25350504

  5. A Cost-Effective Energy-Recovering Sustain Driving Circuit for ac Plasma Display Panels

    NASA Astrophysics Data System (ADS)

    Lim, Jae Kwang; Tae, Heung-Sik; Choi, Byungcho; Kim, Seok Gi

    A new sustain driving circuit, featuring an energy-recovering function with simple structure and minimal component count, is proposed as a cost-effective solution for driving plasma display panels during the sustaining period. Compared with existing solutions, the proposed circuit reduces the number of semiconductor switches and reactive circuit components without compromising the circuit performance and gas-discharging characteristics. In addition, the proposed circuit utilizes the harness wire as an inductive circuit component, thereby further simplifying the circuit structure. The performance of the proposed circuit is confirmed with a 42-inch plasma display panel.

  6. Dynamic tensile forces drive collective cell migration through three-dimensional extracellular matrices

    PubMed Central

    Gjorevski, Nikolce; S. Piotrowski, Alexandra; Varner, Victor D.; Nelson, Celeste M.

    2015-01-01

    Collective cell migration drives tissue remodeling during development, wound repair, and metastatic invasion. The physical mechanisms by which cells move cohesively through dense three-dimensional (3D) extracellular matrix (ECM) remain incompletely understood. Here, we show directly that migration of multicellular cohorts through collagenous matrices occurs via a dynamic pulling mechanism, the nature of which had only been inferred previously in 3D. Tensile forces increase at the invasive front of cohorts, serving a physical, propelling role as well as a regulatory one by conditioning the cells and matrix for further extension. These forces elicit mechanosensitive signaling within the leading edge and align the ECM, creating microtracks conducive to further migration. Moreover, cell movements are highly correlated and in phase with ECM deformations. Migrating cohorts use spatially localized, long-range forces and consequent matrix alignment to navigate through the ECM. These results suggest biophysical forces are critical for 3D collective migration. PMID:26165921

  7. Application of Laser Ranging and VLBI Data to a Study of Plate Tectonic Driving Forces

    NASA Technical Reports Server (NTRS)

    Solomon, S. C.

    1980-01-01

    The conditions under which changes in plate driving or resistive forces associated with plate boundary earthquakes are measurable with laser ranging or very long base interferometry were investigated. Aspects of plate forces that can be characterized by such measurements were identified. Analytic solutions for two dimensional stress diffusion in a viscoelastic plate following earthquake faulting on a finite fault, finite element solutions for three dimensional stress diffusion in a viscoelastic Earth following earthquake faulting, and quantitative constraints from modeling of global intraplate stress on the magnitude of deviatoric stress in the lithosphere are among the topics discussed.

  8. A study on tyre force distribution controls for full drive-by-wire electric vehicle

    NASA Astrophysics Data System (ADS)

    Suzuki, Yuta; Kano, Yoshio; Abe, Masato

    2014-05-01

    Feed-forward types of tyre force distribution controls with some norms for motion controls of a full drive-by-wire electric vehicle are presented. One of the norms for the distribution control introduced is minimising tyre workload and another one is minimising tyre dissipation energy due to tyre slip during vehicle motion. The effects of the distribution controls are substantiated using an experimental vehicle on a proving ground. Especially the effects of the tyre force distribution norms on improving vehicle stability and on reducing the tyre energy dissipation caused by tyre slip are investigated.

  9. Electronic structure and driving forces in β-cyclodextrin: Diclofenac inclusion complexes

    NASA Astrophysics Data System (ADS)

    Bogdan, Diana; Morari, C.

    2007-07-01

    We investigate the geometry and electronic structure for complexes of β-cyclodextrin with diclofenac using DFT calculations. The effect of solvent is explicitly taken into account. This investigation allows us to draw meaningful conclusions upon the stability of the complex and the nature of the driving forces leading to the complexation process. In particular we emphasize the role of the water, by pointing out the changes in the solvent's electronic structure for different docking geometries.

  10. Testing thermal gradient driving force for grain boundary migration using molecular dynamics simulations

    SciTech Connect

    Bai, Xian-Ming; Zhang, Yongfeng; Tonks, Michael R.

    2015-02-01

    Strong thermal gradients in low-thermal-conductivity ceramics may drive extended defects, such as grain boundaries and voids, to migrate in preferential directions. In this work, molecular dynamics simulations are conducted to study thermal gradient driven grain boundary migration and to verify a previously proposed thermal gradient driving force equation, using uranium dioxide as a model system. It is found that a thermal gradient drives grain boundaries to migrate up the gradient and the migration velocity increases under a constant gradient owing to the increase in mobility with temperature. Different grain boundaries migrate at very different rates due to their different intrinsic mobilities. The extracted mobilities from the thermal gradient driven simulations are compared with those calculated from two other well-established methods and good agreement between the three different methods is found, demonstrating that the theoretical equation of the thermal gradient driving force is valid, although a correction of one input parameter should be made. The discrepancy in the grain boundary mobilities between modeling and experiments is also discussed.

  11. Theoretical analysis of the formation driving force and decreased sensitivity for CL-20 cocrystals

    NASA Astrophysics Data System (ADS)

    Zhou, Jun-Hong; Shi, Liang-Wei; Zhang, Chao-Yang; Li, Hong-Zhen; Chen, Min-Bo; Chen, Wei-Ming

    2016-07-01

    Methods that analyze the driving force in the formation of the new energetic cocrystal are proposed in this paper. Various intermolecular interactions in the 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazatetracyclo [5.5.0.05,9.03,11]dodecane (CL-20) cocrystals are compared with those in pure CL-20 and coformer crystals by atom in molecule (AIM) and Hirshfeld surface methods under the supramolecular cluster model. The driving force in the formation of the CL-20 cocrystals is analyzed. The main driving force in the formation of the cocrystal CL-20/HMX comes from the O···H interactions, that in the formation of the cocrystal CL-20/TNT from the O···H and C···O interactions, and that in the formation of the cocrystal CL-20/BTF from the N···H and N···O interactions. Other interactions in the CL-20 cocrystals only contribute to their stabilization. At the same time, the reasons for the decreased impact sensitivity of the CL-20 cocrystals are also analyzed. They are the strengthening of the intermolecular interactions, the reducing of the free space, and the changing of the surrounding of CL-20 molecule in the CL-20 cocrystals in comparison with those in the pure CL-20 crystal.

  12. Theoretical analysis of the formation driving force and decreased sensitivity for CL-20 cocrystals

    NASA Astrophysics Data System (ADS)

    Zhou, Jun-Hong; Shi, Liang-Wei; Zhang, Chao-Yang; Li, Hong-Zhen; Chen, Min-Bo; Chen, Wei-Ming

    2016-07-01

    Methods that analyze the driving force in the formation of the new energetic cocrystal are proposed in this paper. Various intermolecular interactions in the 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazatetracyclo [5.5.0.05,9.03,11]dodecane (CL-20) cocrystals are compared with those in pure CL-20 and coformer crystals by atom in molecule (AIM) and Hirshfeld surface methods under the supramolecular cluster model. The driving force in the formation of the CL-20 cocrystals is analyzed. The main driving force in the formation of the cocrystal CL-20/HMX comes from the O···H interactions, that in the formation of the cocrystal CL-20/TNT from the O···H and C···O interactions, and that in the formation of the cocrystal CL-20/BTF from the N···H and N···O interactions. Other interactions in the CL-20 cocrystals only contribute to their stabilization. At the same time, the reasons for the decreased impact sensitivity of the CL-20 cocrystals are also analyzed. They are the strengthening of the intermolecular interactions, the reducing of the free space, and the changing of the surrounding of CL-20 molecule in the CL-20 cocrystals in comparison with those in the pure CL-20 crystal.

  13. Tuning the driving force for exciton dissociation in single-walled carbon nanotube heterojunctions.

    PubMed

    Ihly, Rachelle; Mistry, Kevin S; Ferguson, Andrew J; Clikeman, Tyler T; Larson, Bryon W; Reid, Obadiah; Boltalina, Olga V; Strauss, Steven H; Rumbles, Garry; Blackburn, Jeffrey L

    2016-06-01

    Understanding the kinetics and energetics of interfacial electron transfer in molecular systems is crucial for the development of a broad array of technologies, including photovoltaics, solar fuel systems and energy storage. The Marcus formulation for electron transfer relates the thermodynamic driving force and reorganization energy for charge transfer between a given donor/acceptor pair to the kinetics and yield of electron transfer. Here we investigated the influence of the thermodynamic driving force for photoinduced electron transfer (PET) between single-walled carbon nanotubes (SWCNTs) and fullerene derivatives by employing time-resolved microwave conductivity as a sensitive probe of interfacial exciton dissociation. For the first time, we observed the Marcus inverted region (in which driving force exceeds reorganization energy) and quantified the reorganization energy for PET for a model SWCNT/acceptor system. The small reorganization energies (about 130 meV, most of which probably arises from the fullerene acceptors) are beneficial in minimizing energy loss in photoconversion schemes. PMID:27219706

  14. High performance control of a three-level IGBT inverter fed AC drive

    SciTech Connect

    Zhang, J.

    1995-12-31

    Three-level PWM inverters have been increasingly employed in industry and traction applications where high power and efficiency energy conversions are required. This paper presents a high performance control of a cage induction motor drive fed by a 100 Hp three-level IGBT inverter operating at a low switching frequency. A practical math model of the drive control system is established to aid in the control design to improve the system stability, dynamic performance and robustness over a wide speed range. The modeling and the simulation in Matlab/Simulink facilitate the self-tuning of the regulators in the multi-loop systems. The field oriented control and three-level space-vector modulation together with the drive protection and diagnostics are implemented in software based on a DSP TMS320C31. Experimental results based on the IGBT inverter prototype are given to verify the design and performance. Test results in motor common-mode voltage reduction and inverter neutral-point potential control re also briefly presented.

  15. Facilitating Implementation of Interprofessional Collaborative Practices Into Primary Care: A Trilogy of Driving Forces.

    PubMed

    Bareil, Céline; Duhamel, Fabie; Lalonde, Lyne; Goudreau, Johanne; Hudon, Eveline; Lussier, Marie-Thérèse; Lévesque, Lise; Lessard, Sylvie; Turcotte, Alain; Lalonde, Gilles

    2015-01-01

    Implementing interprofessional collaborative practices in primary care is challenging, and research about its facilitating factors remains scarce. The goal of this participatory action research study was to better understand the driving forces during the early stage of the implementation process of a community-driven and patient-focused program in primary care titled "TRANSforming InTerprofessional cardiovascular disease prevention in primary care" (TRANSIT). Eight primary care clinics in Quebec, Canada, agreed to participate by creating and implementing an interprofessional facilitation team (IFT). Sixty-three participants volunteered to be part of an IFT, and 759 patients agreed to participate. We randomized six clinics into a supported facilitation ("supported") group, with an external facilitator (EF) and financial incentives for participants. We assigned two clinics to an unsupported facilitation ("unsupported") group, with no EF or financial incentives. After 3 months, we held one interview for the two EFs. After 6 months, we held eight focus groups with IFT members and another interview with each EF. The analyses revealed three key forces: (1) opportunity for dialogue through the IFT, (2) active role of the EF, and (3) change implementation budgets. Decision-makers designing implementation plans for interprofessional programs should ensure that these driving forces are activated. Further research should examine how these forces affect interprofessional practices and patient outcomes. PMID:26364352

  16. Quantifying the net slab pull force as a driving mechanism for plate tectonics

    NASA Astrophysics Data System (ADS)

    Schellart, W. P.

    2004-04-01

    It has remained unclear how much of the negative buoyancy force of the slab (FB) is used to pull the trailing plate at the surface into the mantle. Here I present three-dimensional laboratory experiments to quantify the net slab pull force (FNSP) with respect to FB during subduction. Results show that FNSP increases with increasing slab length and dip up to ~8-12% of FB, making FNSP up to twice as large as the ridge push force. The remainder of FB is primarily used to drive rollback-induced mantle flow (~70%), to bend the subducting plate at the trench (~15-30%) and to overcome shear resistance between slab and mantle (0-8%).

  17. Frequency Domain Analysis of Beat-Less Control Method for Converter-Inverter Driving Systems Applied to AC Electric Cars

    NASA Astrophysics Data System (ADS)

    Kimura, Akira

    In inverter-converter driving systems for AC electric cars, the DC input voltage of an inverter contains a ripple component with a frequency that is twice as high as the line voltage frequency, because of a single-phase converter. The ripple component of the inverter input voltage causes pulsations on torques and currents of driving motors. To decrease the pulsations, a beat-less control method, which modifies a slip frequency depending on the ripple component, is applied to the inverter control. In the present paper, the beat-less control method was analyzed in the frequency domain. In the first step of the analysis, transfer functions, which revealed the relationship among the ripple component of the inverter input voltage, the slip frequency, the motor torque pulsation and the current pulsation, were derived with a synchronous rotating model of induction motors. An analysis model of the beat-less control method was then constructed using the transfer functions. The optimal setting of the control method was obtained according to the analysis model. The transfer functions and the analysis model were verified through simulations.

  18. Optomechanically induced transparency in the presence of an external time-harmonic-driving force

    PubMed Central

    Ma, Jinyong; You, Cai; Si, Liu-Gang; Xiong, Hao; Li, Jiahua; Yang, Xiaoxue; Wu, Ying

    2015-01-01

    We propose a potentially valuable scheme to measure the properties of an external time-harmonic-driving force with frequency ω via investigating its interaction with the combination of a pump field and a probe field in a generic optomechanical system. We show that the spectra of both the cavity field and output field in the configuration of optomechanically induced transparency are greatly modified by such an external force, leading to many interesting linear and non-linear effects, such as the asymmetric structure of absorption in the frequency domain and the antisymmetry breaking of dispersion near ω = ωm. Furthermore, we find that our scheme can be used to measure the initial phase of the external force. More importantly, this setup may eliminate the negative impact of thermal noise on the measurement of the weak external force in virtue of the process of interference between the probe field and the external force. Finally, we show that our configuration can be employed to improve the measurement resolution of the radiation force produced by a weak ultrasonic wave. PMID:26062029

  19. Land use change and its driving forces in alluvial-plain oasis

    NASA Astrophysics Data System (ADS)

    Xiao, Luxiang; Zhang, Zengxiang; Chen, Xi; Luo, Geping; Wen, Qingke

    2007-11-01

    Land use change and its driving factors are hot topics of global change research, and also important topics of sustainable development. This paper selected a small area in alluvial plain oasis in Xinjiang Autonomous region of China as the study area. Using Landsat TM data of 1987, 1998 and 2004, the dynamic process of the spatial-temporal characteristics of land use changes were analyzed to improve understanding and to find the driving forces of land use changes so that sustainable land utilization could be practiced. During the 17 years salt-alkali tolerant cropland, cereal cropland, vegetable-fruit land, and shrubbery, had decreased remarkably by 78.59%, 85.95%, 92.13%, 68.43%, respectively. Cotton-liquorice land, grape-hop land, planted forest, residential area in town, residential area in village, and saline-alkaline field had increased dramatically. The increased percentage received the value of 2432.11%, 10103.18%, 889.91%, 222.45%, 96.00%, 44.18%, respectively. By the logistic regression, the main driving factors were derived for each land use type. The advance of technology (fertilizer input, irrigation quota, and animal labor et al.) and market (unit are yield net) were the main driving factors. Policy, in a higher level, influenced the land use dynamics for all the land use changes.

  20. Driving force of binding of amyloid {beta}-protein to lipid bilayers

    SciTech Connect

    Ikeda, Keisuke; Matsuzaki, Katsumi

    2008-06-06

    Amyloid {beta}-protein (A{beta}) has been reported to interact with a variety of lipid species, although the thermodynamic driving force remains unclear. We investigated the binding of A{beta}s labeled with the dye diethylaminocoumarin (DAC-A{beta}s) to lipid bilayers under various conditions. DAC-A{beta}-(1-40) electrostatically bound to anionic and cationic lipids at acidic and alkaline interfacial pH, respectively. However, at neutral pH, electroneutral A{beta} did not bind to these lipids, indicating little hydrophobic interaction between A{beta}-(1-40) and the acyl chains of lipids. In contrast, DAC-A{beta} associated with glycolipids even under electroneutral conditions. These results suggested that hydrogen-bonding as well as hydrophobic interactions with sugar groups of glycolipids drive the membrane binding of A{beta}-(1-40)

  1. Multiple Driving Forces Required for Efficient Secretion of Autotransporter Virulence Proteins*

    PubMed Central

    Drobnak, Igor; Braselmann, Esther; Clark, Patricia L.

    2015-01-01

    Autotransporter (AT) proteins are a broad class of virulence proteins from Gram-negative bacterial pathogens that require their own C-terminal transmembrane domain to translocate their N-terminal passenger across the bacterial outer membrane (OM). But given the unavailability of ATP or a proton gradient across the OM, it is unknown what energy source(s) drives this process. Here we used a combination of computational and experimental approaches to quantitatively compare proposed AT OM translocation mechanisms. We show directly for the first time that when translocation was blocked an AT passenger remained unfolded in the periplasm. We demonstrate that AT secretion is a kinetically controlled, non-equilibrium process coupled to folding of the passenger and propose a model connecting passenger conformation to secretion kinetics. These results reconcile seemingly contradictory reports regarding the importance of passenger folding as a driving force for OM translocation but also reveal that another energy source is required to initiate translocation. PMID:25670852

  2. Finite element modeling of stress in the Nazca plate - Driving forces and plate boundary earthquakes

    NASA Technical Reports Server (NTRS)

    Richardson, R. M.

    1978-01-01

    The state of stress within the Nazca plate due to plate driving forces and large plate boundary earthquakes has been analyzed by applying a finite element method using the wave front solution technique to models of the intraplate stress field in a single plate using a refined grid. Although only static elastic models have been explicitly calculated, certain limiting cases of an elastic plate over a viscous asthenosphere were also treated. A state of nearly east-west compression inferred from the source mechanism of thrust earthquakes in the interior of the plate requires ridge pushing forces. The net pulling force on the oceanic plate by the subducted slab has a maximum value comparable to pushing forces. The estimated horizontal deviatoric stress in intraplate regions, based on potential forces associated with the ridge, is on the order of a few hundred bars. The intraplate stress field in the region of the 1960 earthquake may change by a few tens of bars at most once the asthenosphere has relaxed, with changes on the order of one bar occurring at greater distances into the plate. The changes in the intraplate stress field are probably not noticeable unless the lithosphere is near failure.

  3. Nonlinear dynamics, rectification, and phase locking for particles on symmetrical two-dimensional periodic substrates with dc and circular ac drives.

    PubMed

    Reichhardt, C; Olson Reichhardt, C J; Hastings, M B

    2004-05-01

    We investigate the dynamical motion of particles on a two-dimensional symmetric periodic substrate in the presence of both a dc drive along a symmetry direction of the periodic substrate and an additional circular ac drive. For large enough ac drives, the particle orbit encircles one or more potential maxima of the periodic substrate. In this case, when an additional increasing dc drive is applied in the longitudinal direction, the longitudinal velocity increases in a series of discrete steps that are integer multiples of a omega/(2 pi), where a is the lattice constant of the substrate. Fractional steps can also occur. These integer and fractional steps correspond to distinct stable dynamical orbits. A number of these phases also show a rectification in the positive or negative transverse direction where a nonzero transverse velocity occurs in the absence of a dc transverse drive. We map out the phase diagrams of the regions of rectification as a function of ac amplitude, and find a series of tongues. Most of the features, including the steps in the longitudinal velocity and the transverse rectification, can be captured with a simple toy model and by arguments from nonlinear maps. We have also investigated the effects of thermal disorder and incommensuration on the rectification phenomena, and find that for increasing disorder, the rectification regions are gradually smeared and the longitudinal velocity steps are no longer flat but show a linearly increasing velocity. PMID:15244891

  4. Role of Chemical Driving Force in Martensitic Transformations of High-Purity Fe-Cr-Ni Alloys

    NASA Astrophysics Data System (ADS)

    Behjati, P.; Najafizadeh, A.

    2011-12-01

    The main objective of the present work is to point out the respective roles of chemical driving force and stacking fault energy (SFE) in the occurrence of martensitic transformations in high-purity Fe-Cr-Ni alloys. For this purpose, the transmission electron microscope (TEM), X-ray diffractometer, thermal differential microanalyzer (TDA), and tension test were employed to report M s temperatures, austenite stacking fault energies, and driving forces for the concerned alloys. It was observed that the martensitic transformations in the studied alloys occur through the γ → ɛ → α' steps. As a remarkable result, it was shown that a low SFE, if necessary to ɛ-phase nucleation, is not a sufficient condition for nucleation of α' phase. In fact, the formation of stable α' nuclei from α' embryos occur if the required chemical driving force is provided. Also, an equation was proposed for the kinetics of spontaneous martensitic transformation as a function of driving force.

  5. Remote sensing monitoring and driving force analysis to forest and greenbelt in Zhuhai

    NASA Astrophysics Data System (ADS)

    Yuliang Qiao, Pro.

    As an important city in the southern part of Chu Chiang Delta, Zhuhai is one of the four special economic zones which are opening up to the outside at the earliest in China. With pure and fresh air and trees shading the street, Zhuhai is a famous beach port city which is near the mountain and by the sea. On the basis of Garden City, the government of Zhuhai decides to build National Forest City in 2011, which firstly should understand the situation of greenbelt in Zhuhai in short term. Traditional methods of greenbelt investigation adopt the combination of field surveying and statistics, whose efficiency is low and results are not much objective because of artificial influence. With the adventure of the information technology such as remote sensing to earth observation, especially the launch of many remote sensing satellites with high resolution for the past few years, kinds of urban greenbelt information extraction can be carried out by using remote sensing technology; and dynamic monitoring to spatial pattern evolvement of forest and greenbelt in Zhuhai can be achieved by the combination of remote sensing and GIS technology. Taking Landsat5 TM data in 1995, Landsat7 ETM+ data in 2002, CCD and HR data of CBERS-02B in 2009 as main information source, this research firstly makes remote sensing monitoring to dynamic change of forest and greenbelt in Zhuhai by using the combination of vegetation coverage index and three different information extraction methods, then does a driving force analysis to the dynamic change results in 3 months. The results show: the forest area in Zhuhai shows decreasing tendency from 1995 to 2002, increasing tendency from 2002 to 2009; overall, the forest area show a small diminution tendency from 1995 to 2009. Through the comparison to natural and artificial driving force, the artificial driving force is the leading factor to the change of forest and greenbelt in Zhuhai. The research results provide a timely and reliable scientific basis

  6. Theory of polymer translocation through a flickering nanopore under an alternating driving force

    NASA Astrophysics Data System (ADS)

    Sarabadani, Jalal; Ikonen, Timo; Ala-Nissila, Tapio

    2015-08-01

    We develop a theory for polymer translocation driven by a time-dependent force through an oscillating nanopore. To this end, we extend the iso-flux tension propagation theory [Sarabadani et al., J. Chem. Phys. 141, 214907 (2014)] for such a setup. We assume that the external driving force in the pore has a component oscillating in time, and the flickering pore is similarly described by an oscillating term in the pore friction. In addition to numerically solving the model, we derive analytical approximations that are in good agreement with the numerical simulations. Our results show that by controlling either the force or pore oscillations, the translocation process can be either sped up or slowed down depending on the frequency of the oscillations and the characteristic time scale of the process. We also show that while in the low and high frequency limits, the translocation time τ follows the established scaling relation with respect to chain length N0, in the intermediate frequency regime small periodic, fluctuations can have drastic effects on the dynamical scaling. The results can be easily generalized for non-periodic oscillations and elucidate the role of time dependent forces and pore oscillations in driven polymer translocation.

  7. Proton-coupled electron transfers: pH-dependent driving forces? Fundamentals and artifacts.

    PubMed

    Bonin, Julien; Costentin, Cyrille; Robert, Marc; Routier, Mathilde; Savéant, Jean-Michel

    2013-09-25

    Besides its own interest, tryptophan oxidation by photogenerated Ru complexes is one of the several examples where concerted proton-electron transfer (CPET) to water as proton acceptor endowed with a pH-dependent driving force has been invoked to explain the data. Since this notion is contrary to the very basic principles of chemical physics, it was interesting to attempt uncovering the source of this contradiction with an easily accessible substrate. Careful examination of the oxidation of the tryptophan (ethyl ester derivative) bearing a NH3(+)/NH2 group showed that there is no trace of such an unconventional H2O-CPET with a pH-dependent driving force. The reaction mechanism simply consists, with both the NH3(+) acid and NH2 basic forms of the tryptophan derivative, in a rate-determining electron-transfer step followed by deprotonation steps. The same is true with the ethyl ester-methyl amide derivative of tryptophan, whose behavior is even simpler since the molecule does not bear an acid-base group. No such unconventional H2O-CPET was found with phenol, another easily accessible substrate. It may thus be inferred that the same applies to less easily available systems in which electron transfer occurs intramolecularly. These observations help to rid the road of such artificial obstacles and improve present models of H2O-CPET reactions, a landmark towards the understanding of the role of water chains in natural systems. PMID:23972082

  8. Driving forces behind the construction of an eco-compensation mechanism for wetlands in China

    NASA Astrophysics Data System (ADS)

    Wang, Changhai

    2016-09-01

    This research revealed important driving forces behind the construction of an eco-compensation mechanism for wetlands (DFEMW) in China. Using China's provincial panel data from 1978 to 2008, a fixed-effects model was used to analyze the impacts of agricultural production systems on wetlands. We identified three DFEMW as follows: the change of wetland resources and protection measures in China; declaration and implementation of the provincial Wetland Protection Ordinance; and wetland degradation by agricultural production systems, which necessitated the establishment of a wetland eco-compensation mechanism. In addition to the DFEMW, a significant positive correlation between wetland area and both rural population and gross agricultural production was identified, in addition to a negative correlation with chemical fertilizer usage, reservoir storage capacity, and irrigation area. The underlying reasons for the serious degradation and inadequate protection of wetlands were market failure and government failure; these were the driving forces behind the need to establish a wetland eco-compensation mechanism. From a governmental perspective, it has been difficult to rectify market failures in resource distribution and thus to prevent wetland degradation. Factors include conflicts of interest, lack of investment, effective special laws, a simple means to protect wetlands, and a multidisciplinary management system. Therefore, the key factor is the coordination of interest relationships between those who utilize wetlands and those who seek to minimize wetland degradation and effectively protect wetlands.

  9. Driving forces behind the construction of an eco-compensation mechanism for wetlands in China

    NASA Astrophysics Data System (ADS)

    Wang, Changhai

    2016-03-01

    This research revealed important driving forces behind the construction of an eco-compensation mechanism for wetlands (DFEMW) in China. Using China's provincial panel data from 1978 to 2008, a fixed-effects model was used to analyze the impacts of agricultural production systems on wetlands. We identified three DFEMW as follows: the change of wetland resources and protection measures in China; declaration and implementation of the provincial Wetland Protection Ordinance; and wetland degradation by agricultural production systems, which necessitated the establishment of a wetland eco-compensation mechanism. In addition to the DFEMW, a significant positive correlation between wetland area and both rural population and gross agricultural production was identified, in addition to a negative correlation with chemical fertilizer usage, reservoir storage capacity, and irrigation area. The underlying reasons for the serious degradation and inadequate protection of wetlands were market failure and government failure; these were the driving forces behind the need to establish a wetland eco-compensation mechanism. From a governmental perspective, it has been difficult to rectify market failures in resource distribution and thus to prevent wetland degradation. Factors include conflicts of interest, lack of investment, effective special laws, a simple means to protect wetlands, and a multidisciplinary management system. Therefore, the key factor is the coordination of interest relationships between those who utilize wetlands and those who seek to minimize wetland degradation and effectively protect wetlands.

  10. Human health and the water environment: using the DPSEEA framework to identify the driving forces of disease.

    PubMed

    Gentry-Shields, Jennifer; Bartram, Jamie

    2014-01-15

    There is a growing awareness of global forces that threaten human health via the water environment. A better understanding of the dynamic between human health and the water environment would enable prediction of the significant driving forces and effective strategies for coping with or preventing them. This report details the use of the Driving Force-Pressure-State-Exposure-Effect-Action (DPSEEA) framework to explore the linkage between water-related diseases and their significant driving forces. The DPSEEA frameworks indicate that a select group of driving forces, including population growth, agriculture, infrastructure (dams and irrigation), and climate change, is at the root cause of key global disease burdens. Construction of the DPSEEA frameworks also allows for the evaluation of public health interventions. Sanitation was found to be a widely applicable and effective intervention, targeting the driver/pressure linkage of most of the water-related diseases examined. Ultimately, the DPSEEA frameworks offer a platform for constituents in both the health and environmental fields to collaborate and commit to a common goal targeting the same driving forces. PMID:24036221

  11. Application of laser ranging and VLBI data to a study of plate tectonic driving forces. [finite element method

    NASA Technical Reports Server (NTRS)

    Solomon, S. C.

    1980-01-01

    The measurability of changes in plate driving or resistive forces associated with plate boundary earthquakes by laser rangefinding or VLBI is considered with emphasis on those aspects of plate forces that can be characterized by such measurements. Topics covered include: (1) analytic solutions for two dimensional stress diffusion in a plate following earthquake faulting on a finite fault; (2) two dimensional finite-element solutions for the global state of stress at the Earth's surface for possible plate driving forces; and (3) finite-element solutions for three dimensional stress diffusion in a viscoelastic Earth following earthquake faulting.

  12. Calculations of Alfvén wave driving forces, plasma flow, and current drive in the Tokamak Chauffage Alfvén wave experiment in Brazil (TCABR)

    NASA Astrophysics Data System (ADS)

    Amarante-Segundo, G.; Elfimov, A. G.; Galvão, R. M. O.; Ross, D. W.; Nascimento, I. C.

    2001-01-01

    The current and plasma flows driven by ponderomotive forces are calculated for tokamak plasmas, using a kinetic code in the Alfvén range of frequencies. The rf (radio frequency) ponderomotive force is expressed as a sum of a gradient part and of a wave momentum transfer force, which is proportional to wave dissipation (electron Landau damping and transit time magnetic pumping). Finally, the rf force is balanced by the viscous force in the fluid momentum response to the rf fields in the plasma. The relative magnitudes of the different forces for kinetic and global Alfvén waves with low phase velocities are explicitly calculated. It is shown that, dissipating in electrons, Alfvén waves can drive ion flow via the gradient force, which is dominated in m=0-sideband harmonic resonance induced by toroidal mode coupling. Estimates of power requirements to drive substantial poloidal flow in the Tokamak Chauffage Alfvén wave heating experiment in Brazil (TCABR) [L. Ruchko, M. C. Andrade, R. M. O. Galvão, Nucl. Fusion 30, 503 (1996)] are made.

  13. The role of biotic forces in driving macroevolution: beyond the Red Queen

    PubMed Central

    Voje, Kjetil L.; Holen, Øistein H.; Liow, Lee Hsiang; Stenseth, Nils Chr.

    2015-01-01

    A multitude of hypotheses claim that abiotic factors are the main drivers of macroevolutionary change. By contrast, Van Valen's Red Queen hypothesis is often put forward as the sole representative of the view that biotic forcing is the main evolutionary driver. This imbalance of hypotheses does not reflect our current knowledge: theoretical work demonstrates the plausibility of biotically driven long-term evolution, whereas empirical work suggests a central role for biotic forcing in macroevolution. We call for a more pluralistic view of how biotic forces may drive long-term evolution that is compatible with both phenotypic stasis in the fossil record and with non-constant extinction rates. Promising avenues of research include contrasting predictions from relevant theories within ecology and macroevolution, as well as embracing both abiotic and biotic proxies while modelling long-term evolutionary data. By fitting models describing hypotheses of biotically driven macroevolution to data, we could dissect their predictions and transcend beyond pattern description, possibly narrowing the divide between our current understanding of micro- and macroevolution. PMID:25948685

  14. The role of biotic forces in driving macroevolution: beyond the Red Queen.

    PubMed

    Voje, Kjetil L; Holen, Øistein H; Liow, Lee Hsiang; Stenseth, Nils Chr

    2015-06-01

    A multitude of hypotheses claim that abiotic factors are the main drivers of macroevolutionary change. By contrast, Van Valen's Red Queen hypothesis is often put forward as the sole representative of the view that biotic forcing is the main evolutionary driver. This imbalance of hypotheses does not reflect our current knowledge: theoretical work demonstrates the plausibility of biotically driven long-term evolution, whereas empirical work suggests a central role for biotic forcing in macroevolution. We call for a more pluralistic view of how biotic forces may drive long-term evolution that is compatible with both phenotypic stasis in the fossil record and with non-constant extinction rates. Promising avenues of research include contrasting predictions from relevant theories within ecology and macroevolution, as well as embracing both abiotic and biotic proxies while modelling long-term evolutionary data. By fitting models describing hypotheses of biotically driven macroevolution to data, we could dissect their predictions and transcend beyond pattern description, possibly narrowing the divide between our current understanding of micro- and macroevolution. PMID:25948685

  15. Molecular dynamics simulations of grain boundary mobility in Al, Cu and γ-Fe using a symmetrical driving force

    NASA Astrophysics Data System (ADS)

    Ulomek, F.; Mohles, V.

    2014-07-01

    We present a new artificial driving force for the determination of grain boundary mobility by molecular dynamics. The new driving force is a symmetric version of the synthetic driving force formerly introduced by Janssens et al 2006 Nature Mater. 5 124-7. The new version depends on two orientation parameters instead of one. We analyze the advantages and disadvantages of these two driving force methods. Grain boundary mobilities are simulated for eight symmetric CSL tilt grain boundaries in Al, Cu and γ-Fe, and two MD potentials for each of these materials. Boundary conditions are kept as similar as possible to show the influence of the different materials and to compare to the influence of the different MD potential types on simulated GB mobilities. We find that the newly introduced artificial driving force is a slight improvement, but it cannot remove the shortcomings of the original approach. Also, it is found that the differences in calculated MD mobilities between different materials are of the same order as those between different MD potentials of any one element. Sources for such differences are identified and classified by severity.

  16. The driving force for glide of a threading dislocation in a strained epitaxial layer on a substrate

    NASA Astrophysics Data System (ADS)

    Freund, L. B.

    T HE PROCESS of epitaxial growth of a very thin layer onto a substrate crystal is considered for the particular situation in which the layer and substrate materials have the same crystal structure and orientation but different lattice parameters. Under these conditions, the layer grows with an intrinsic elastic strain determined by the mismatch in lattice parameters. The associated stress in the crystalline layer provides a driving force for the nucleation and motion of defects, primarily dislocations. The focus here is on the glide of a dislocation extending from the free surface of the layer to the layer-substrate interface, the so-called threading dislocation. A general definition of driving force for glide of a threading dislocation is introduced on the basis of work arguments. The definition is then applied to calculate the driving force for steady motion of an isolated threading dislocation in a strained layer, and the result includes Matthews' critical thickness concept as one of its features. Next, a kinetic equation for glide of a dislocation in semiconductor materials is proposed to estimate the glide rate of a threading dislocation in these low mobility materials. Finally, for the case of cubic materials, the general definition of driving force is applied to estimate the additional driving force on a threading dislocation due to an encounter with a dislocation on an intersecting glide plane. The results indicate that this effect is significant in blocking the glide of a threading dislocation for large mismatch strains and for layer thicknesses near the critical thickness.

  17. The Impact of Evolutionary Driving Forces on Human Complex Diseases: A Population Genetics Approach

    PubMed Central

    Saeb, Amr T. M.; Al-Naqeb, Dhekra

    2016-01-01

    Investigating the molecular evolution of human genome has paved the way to understand genetic adaptation of humans to the environmental changes and corresponding complex diseases. In this review, we discussed the historical origin of genetic diversity among human populations, the evolutionary driving forces that can affect genetic diversity among populations, and the effects of human movement into new environments and gene flow on population genetic diversity. Furthermore, we presented the role of natural selection on genetic diversity and complex diseases. Then we reviewed the disadvantageous consequences of historical selection events in modern time and their relation to the development of complex diseases. In addition, we discussed the effect of consanguinity on the incidence of complex diseases in human populations. Finally, we presented the latest information about the role of ancient genes acquired from interbreeding with ancient hominids in the development of complex diseases. PMID:27313952

  18. The Impact of Evolutionary Driving Forces on Human Complex Diseases: A Population Genetics Approach.

    PubMed

    Saeb, Amr T M; Al-Naqeb, Dhekra

    2016-01-01

    Investigating the molecular evolution of human genome has paved the way to understand genetic adaptation of humans to the environmental changes and corresponding complex diseases. In this review, we discussed the historical origin of genetic diversity among human populations, the evolutionary driving forces that can affect genetic diversity among populations, and the effects of human movement into new environments and gene flow on population genetic diversity. Furthermore, we presented the role of natural selection on genetic diversity and complex diseases. Then we reviewed the disadvantageous consequences of historical selection events in modern time and their relation to the development of complex diseases. In addition, we discussed the effect of consanguinity on the incidence of complex diseases in human populations. Finally, we presented the latest information about the role of ancient genes acquired from interbreeding with ancient hominids in the development of complex diseases. PMID:27313952

  19. On the driving force for crack growth during thermal actuation of shape memory alloys

    NASA Astrophysics Data System (ADS)

    Baxevanis, T.; Parrinello, A. F.; Lagoudas, D. C.

    2016-04-01

    The effect of thermomechanically induced phase transformation on the driving force for crack growth in polycrystalline shape memory alloys is analyzed in an infinite center-cracked plate subjected to a thermal actuation cycle under mechanical load in plain strain. Finite element calculations are carried out to determine the mechanical fields near the static crack and the crack-tip energy release rate using the virtual crack closure technique. A substantial increase of the energy release rate - an order of magnitude for some material systems - is observed during the thermal cycle due to the stress redistribution induced by large scale phase transformation. Thus, phase transformation occurring due to thermal variations under mechanical load may result in crack growth if the crack-tip energy release rate reaches a material specific critical value.

  20. Unraveling the genetic driving forces enabling antibiotic resistance at the single cell level

    NASA Astrophysics Data System (ADS)

    Bos, Julia

    Bacteria are champions at finding ways to quickly respond and adapt to environments like the human gut, known as the epicentre of antibiotic resistance. How do they do it? Combining molecular biology tools to microfluidic and fluorescence microscopy technologies, we monitor the behavior of bacteria at the single cell level in the presence of non-toxic doses of antibiotics. By tracking the chromosome dynamics of Escherichia coli cells upon antibiotic treatment, we examine the changes in the number, localization and content of the chromosome copies within one cell compartment or between adjacent cells. I will discuss how our work pictures the bacterial genomic plasticity as a driving force in evolution and how it provides access to the mechanisms controlling the subtle balance between genetic diversity and stability in the development of antibiotic resistance.

  1. Opposing forces of aerosol cooling and El Nino drive coral bleaching on Caribbean reefs.

    PubMed

    Gill, Jennifer A; Watkinson, Andrew R; McWilliams, John P; Côté, Isabelle M

    2006-12-01

    Bleaching of corals as a result of elevated sea surface temperatures (SST) is rapidly becoming a primary source of stress for reefs globally; the scale and extent of this threat will depend on how the drivers of SST interact to influence bleaching patterns. We demonstrate how the opposing forces of the El Niño-Southern Oscillation (ENSO) and levels of atmospheric aerosols drive regional-scale patterns of coral bleaching across the Caribbean. When aerosol levels are low, bleaching is largely determined by El Niño strength, but high aerosol levels mitigate the effects of a severe El Niño. High aerosol levels, resulting principally from recent volcanic activity, have thus protected Caribbean reefs from more frequent widespread bleaching events but cannot be relied on to provide similar protection in the future. PMID:17116861

  2. Rapid Evolutionary Dynamics of Structural Disorder as a Potential Driving Force for Biological Divergence in Flaviviruses

    PubMed Central

    Ortiz, Juan F.; MacDonald, Madolyn L.; Masterson, Patrick; Uversky, Vladimir N.; Siltberg-Liberles, Jessica

    2013-01-01

    Protein structure is commonly regarded to be conserved and to dictate function. Most proteins rely on conformational flexibility to some degree. Are regions that convey conformational flexibility conserved over evolutionary time? Can changes in conformational flexibility alter protein function? Here, the evolutionary dynamics of structurally ordered and disordered (flexible) regions are investigated genome-wide in flaviviruses, revealing that the amount and location of structural disorder fluctuates highly among related proteins. Some regions are prone to shift between structured and flexible states. Increased evolutionary dynamics of structural disorder is observed for some lineages but not in others. Lineage-specific transitions of this kind could alter the conformational ensemble accessible to the same protein in different species, causing a functional change, even if the predominant function remains conserved. Thus, rapid evolutionary dynamics of structural disorder is a potential driving force for phenotypic divergence among flaviviruses. PMID:23418179

  3. Quantitative attribution of major driving forces on soil organic carbon dynamics

    NASA Astrophysics Data System (ADS)

    Wu, Yiping; Liu, Shuguang; Tan, Zhengxi

    2015-03-01

    Soil organic carbon (SOC) storage plays a major role in the global carbon cycle and is affected by many factors including land use/management changes (e.g., biofuel production-oriented changes). However, the contributions of various factors to SOC changes are not well understood and quantified. This study was designed to investigate the impacts of changing farming practices, initial SOC levels, and biological enhancement of grain production on SOC dynamics and to attribute the relative contributions of major driving forces (CO2 enrichment and farming practices) using a fractional factorial modeling design. The case study at a crop site in Iowa in the United States demonstrated that the traditional corn-soybean (CS) rotation could still accumulate SOC over this century (from 4.2 to 6.8 kg C/m2) under the current condition; whereas the continuous-corn (CC) system might have a higher SOC sequestration potential than CS. In either case, however, residue removal could reduce the sink potential substantially. Long-term simulation results also suggested that the equilibrium SOC level may vary greatly (˜5.7 to ˜11 kg C/m2) depending on cropping systems and management practices, and projected growth enhancement could make the magnitudes higher (˜7.8 to ˜13 kg C/m2). Importantly, the factorial design analysis indicated that residue management had the most significant impact (contributing 49.4%) on SOC changes, followed by CO2 Enrichment (37%), Tillage (6.2%), the combination of CO2 Enrichment-Residue removal (5.8%), and Fertilization (1.6%). In brief, this study is valuable for understanding the major forces driving SOC dynamics of agroecosystems and informative for decision-makers when seeking the enhancement of SOC sequestration potential and sustainability of biofuel production, especially in the Corn Belt region of the United States.

  4. Driving Forces of Gyrase Recognition by the Addiction Toxin CcdB*

    PubMed Central

    Simic, Mario; De Jonge, Natalie; Loris, Remy; Vesnaver, Gorazd; Lah, Jurij

    2009-01-01

    Gyrase, an essential bacterial topoisomerase, is the target of several antibiotics (e.g. quinolones) as well as of bacterial toxin CcdB. This toxin, encoded by Escherichia coli toxin-antitoxin module ccd, poisons gyrase by causing inhibition of both transcription and replication. Because the molecular driving forces of gyrase unfolding and CcdB-gyrase binding were unknown, the nature of the CcdB-gyrase recognition remained elusive. Therefore, we performed a detailed thermodynamic analysis of CcdB binding to several fragments of gyrase A subunit (GyrA) that contain the CcdB-binding site. Binding of CcdB to the shorter fragments was studied directly by isothermal titration calorimetry. Its binding to the longer GyrA59 fragment in solution is kinetically limited and was therefore investigated via urea induced unfolding of the GyrA59-CcdB complex and unbound GyrA59 and CcdB, monitored by circular dichroism spectroscopy. Model analysis of experimental data, in combination with the relevant structural information, indicates that CcdB binding to gyrase is an enthalpic process driven mainly by specific interactions between CcdB and the highly stable dimerization domain of the GyrA. The dissection of binding energetics indicates that CcdB-gyrase recognition is accompanied by opening of the tower and catalytic domain of GyrA. Such extensive structural rearrangements appear to be crucial driving forces for the functioning of the ccd toxin-antitoxin module. PMID:19465484

  5. Driving forces for import of waste for energy recovery in Sweden.

    PubMed

    Olofsson, Mattias; Sahlin, Jenny; Ekvall, Tomas; Sundberg, Johan

    2005-02-01

    Between 1996 and 2002, the Swedish import of so-called yellow waste for energy recovery increased. The import mainly consisted of separated wood waste and mixes of used wood and paper and/or plastics that was combusted in district heat production plants (DHPPs). Some mixed waste was imported to waste incineration plants for energy recovery (10% of the import of yellow waste for energy recovery in 2002). The import came primarily from Germany, the Netherlands, Norway, Denmark and Finland. We identified six underlying driving forces for this recent increase of imported waste which are outlined and their interactive issues discussed. --The energy system infrastructure, which enables high energy recovery in Sweden. --The energy taxation, where high Swedish taxes on fossil fuels make relatively expensive solid biofuels the main alternative for base load production of district heat. --The quality of the waste-derived fuels, which has been higher in the exporting countries than in Sweden. --The bans on landfilling within Europe and the shortage of waste treatment capacity. --Taxes on waste management in Europe. --Gate fee differences between exporting countries and Sweden. In the future, the overall strength of these driving forces will probably be weakened. A Swedish tax on waste incineration is being investigated. In other European countries, the ambition to reach the Kyoto targets and increase the renewable electricity production could improve the competitiveness of waste-derived fuels in comparison with fossil fuels. Swedish DHPPs using waste-derived fuels will experience higher costs after the Waste Incineration Directive is fully implemented. The uncertainty about European waste generation and treatment capacity, however, might have a large influence on the future gate fees and thus also on the yellow waste import into Sweden. PMID:15751390

  6. Driving force analysis of the agricultural water footprint in China based on the LMDI method.

    PubMed

    Zhao, Chunfu; Chen, Bin

    2014-11-01

    China's water scarcity problems have become more severe because of the unprecedented economic development and population explosion. Considering agriculture's large share of water consumption, obtaining a clear understanding of Chinese agricultural consumptive water use plays a key role in addressing China's water resource stress and providing appropriate water mitigation policies. We account for the Chinese agricultural water footprint from 1990 to 2009 based on bottom up approach. Then, the underlying driving forces are decomposed into diet structure effect, efficiency effect, economic activity effect, and population effect, and analyzed by applying a log-mean Divisia index (LMDI) model. The results reveal that the Chinese agricultural water footprint has risen from the 94.1 Gm3 in 1990 to 141 Gm3 in 2009. The economic activity effect is the largest positive contributor to promoting the water footprint growth, followed by the population effect and diet structure effect. Although water efficiency improvement as a significant negative effect has reduced overall water footprint, the water footprint decline from water efficiency improvement cannot compensate for the huge increase from the three positive driving factors. The combination of water efficiency improvement and dietary structure adjustment is the most effective approach for controlling the Chinese agricultural water footprint's further growth. PMID:25289879

  7. Changing and Differentiated Urban Landscape in China: Spatiotemporal Patterns and Driving Forces.

    PubMed

    Fang, Chuanglin; Li, Guangdong; Wang, Shaojian

    2016-03-01

    Urban landscape spatiotemporal change patterns and their driving mechanisms in China are poorly understood at the national level. Here we used remote sensing data, landscape metrics, and a spatial econometric model to characterize the spatiotemporal patterns of urban landscape change and investigate its driving forces in China between 1990 and 2005. The results showed that the urban landscape pattern has experienced drastic changes over the past 15 years. Total urban area has expanded approximately 1.61 times, with a 2.98% annual urban-growth rate. Compared to previous single-city studies, although urban areas are expanding rapidly, the overall fragmentation of the urban landscape is decreasing and is more irregular and complex at the national level. We also found a stair-stepping, urban-landscape changing pattern among eastern, central, and western counties. In addition, administrative level, urban size, and hierarchy have effects on the urban landscape pattern. We also found that a combination of landscape metrics can be used to supplement our understanding of the pattern of urbanization. The changes in these metrics are correlated with geographical indicators, socioeconomic factors, infrastructure variables, administrative level factors, policy factors, and historical factors. Our results indicate that the top priority should be strengthening the management of urban planning. A compact and congregate urban landscape may be a good choice of pattern for urban development in China. PMID:26856966

  8. Theory of open-circuit voltage and the driving force of charge separation in pn-junction solar cells

    NASA Astrophysics Data System (ADS)

    Hara, Kosuke O.; Usami, Noritaka

    2013-10-01

    We have derived the formula to calculate the open-circuit voltage in a pn-junction solar cell from carrier densities by considering the driving force of charge separation without using the equation for current. The excess amount of chemical potential of charge carriers is proposed as the origin of the driving force of charge separation, and the voltage formula is derived from the gradient of excess chemical potential. The calculated voltage is shown to agree with the result of a rigorous device simulation for symmetrical pn-homojunction devices with band gaps of 0.6-1.8 eV and majority-carrier densities of 1015-1019 cm-3. The developed formula is, therefore, valid for the pn-homojunction devices, indicating that the driving force of charge separation stems from the excess chemical potential.

  9. Decay Characteristics of Levitation Force of YBCO Bulk Exposed to AC Magnetic Field above NdFeB Guideway

    NASA Astrophysics Data System (ADS)

    Liu, Minxian; Lu, Yiyun; Wang, Suyu; Ma, Guangtong

    2011-04-01

    The superconducting maglev vehicle is one of the most promising applications of HTS bulks. In such a system, the nonuniformity of the magnetic field along the movement direction above the NdFeB guideway is inevitable due to the assembly error and inhomogeneity of the material property of the NdFeB magnet. So it is required to study the characteristics of levitation force of the bulks affected by the non-uniform applied magnetic fields along the moving direction. In this paper, we will study the characteristics of the levitation force relaxation between the HTS bulk and the NdFeB guideway by an experiment in which AC external magnetic field generated by an electromagnet is used to simulate the time-varying external magnetic field caused by the inhomogeneity of the guideway. From the experimental results, it has found that the levitation force is decreasing with the application of the AC external magnetic field, and the decay increasing with the amplitude of the applied magnetic field and is almost independent of the frequency.

  10. Depletion forces drive polymer-like self-assembly in vibrofluidized granular materials†

    PubMed Central

    Nossal, Ralph

    2011-01-01

    Ranging from nano- to granular-scales, control of particle assembly can be achieved by limiting the available free space, for example by increasing the concentration of particles (“crowding”) or through their restriction to 2D environments. It is unclear, however, if self-assembly principles governing thermally-equilibrated molecules can also apply to mechanically-excited macroscopic particles in non-equilibrium steady-state. Here we show that low densities of vibrofluidized steel rods, when crowded by high densities of spheres and confined to quasi-2D planes, can self-assemble into linear polymer-like structures. Our 2D Monte Carlo simulations show similar finite sized aggregates in thermally equilibrated binary mixtures. Using theory and simulations, we demonstrate how depletion interactions create oriented “binding” forces between rigid rods to form these “living polymers.” Unlike rod-sphere mixtures in 3D that can demonstrate well-defined equilibrium phases, our mixtures confined to 2D lack these transitions because lower dimensionality favors the formation of linear aggregates, thus suppressing a true phase transition. The qualitative and quantitative agreement between equilibrium and granular patterning for these mixtures suggests that entropy maximization is the determining driving force for bundling. Furthermore, this study uncovers a previously unknown patterning behavior at both the granular and nanoscales, and may provide insights into the role of crowding at interfaces in molecular assembly. PMID:22039392

  11. Dominant Driving Forces in Human Telomere Quadruplex Binding-Induced Structural Alterations.

    PubMed

    Bončina, Matjaž; Hamon, Florian; Islam, Barira; Teulade-Fichou, Marie-Paule; Vesnaver, Gorazd; Haider, Shozeb; Lah, Jurij

    2015-06-16

    Recently various pathways of human telomere (ht) DNA folding into G-quadruplexes and of ligand binding to these structures have been proposed. However, the key issue as to the nature of forces driving the folding and recognition processes remains unanswered. In this study, structural changes of 22-mer ht-DNA fragment (Tel22), induced by binding of ions (K(+), Na(+)) and specific bisquinolinium ligands, were monitored by calorimetric and spectroscopic methods and by gel electrophoresis. Using the global model analysis of a wide variety of experimental data, we were able to characterize the thermodynamic forces that govern the formation of stable Tel22 G-quadruplexes, folding intermediates, and ligand-quadruplex complexes, and then predict Tel22 behavior in aqueous solutions as a function of temperature, salt concentration, and ligand concentration. On the basis of the above, we believe that our work sets the framework for better understanding the heterogeneity of ht-DNA folding and binding pathways, and its structural polymorphism. PMID:26083930

  12. Equal sensation curves for whole-body vibration expressed as a function of driving force

    NASA Astrophysics Data System (ADS)

    Mansfield, Neil J.; Maeda, Setsuo

    2005-06-01

    Previous studies have shown that the seated human is most sensitive to whole-body vertical vibration at about 5 Hz. Similarly, the body shows an apparent mass resonance at about 5 Hz. Considering these similarities between the biomechanical and subjective responses, it was hypothesized that, at low frequencies, subjective ratings of whole-body vibration might be directly proportional to the driving force. Twelve male subjects participated in a laboratory experiment where subjects sat on a rigid seat mounted on a shaker. The magnitude of a test stimulus was adjusted such that the subjective intensity could be matched to a reference stimulus, using a modified Bruceton test protocol. The sinusoidal reference stimulus was 8-Hz vibration with a magnitude of 0.5 m/s2 rms (or 0.25 m/s2 rms for the 1-Hz test); the sinusoidal test stimuli had frequencies of 1, 2, 4, 16, and 32 Hz. Equal sensation contours in terms of seat acceleration showed data similar to those in the literature. Equal sensation contours in terms of force showed a nominally linear response at 1, 2, and 4 Hz, but an increasing sensitivity at higher frequencies. This is in agreement with a model derived from published subjective and objective fitted data. .

  13. Driving forces for adsorption of polyols onto zeolites from aqueous solutions.

    PubMed

    Mallon, Elizabeth E; Bhan, Aditya; Tsapatsis, Michael

    2010-02-11

    Ambient temperature adsorption isotherms have been developed for C(2)-C(6) diols and triols on small (FER), medium (MWW, MFI, BEA), and large (MOR, FAU) pore zeolites as well as on ordered mesoporous materials (MCM-36, 3DOm-MFI, and SBA-15) using gravimetry. Henry's constants for diol and triol adsorption on silicalite-1 increase exponentially with carbon number demonstrating that confinement of the adsorbate in the zeolite pores is the primary driving force for adsorption. This conclusion is supported by results for propylene glycol adsorption at low coverages on materials differing in topology and chemical composition. It is shown that adsorption decreases with an increase in the adsorbent pore size, and aluminum content only has a marginal effect. Comparison of diol and triol adsorption on silicalite-1 shows that increasing the number of hydroxyl groups causes a decrease in the Henry's constant possibly due to a change of the configuration of the adsorbate in the zeolite pores, while the location of the hydroxyl groups does not have a significant effect. Overall, this study provides evidence that polyol adsorption is primarily a function of dispersion forces that are derived from the fit of the adsorbate in the adsorbent pores. These findings could have an impact on the separation and catalytic conversion of oxygenates in the processing of biomass to chemicals and fuels. PMID:20070098

  14. Dominant Driving Forces in Human Telomere Quadruplex Binding-Induced Structural Alterations

    PubMed Central

    Bončina, Matjaž; Hamon, Florian; Islam, Barira; Teulade-Fichou, Marie-Paule; Vesnaver, Gorazd; Haider, Shozeb; Lah, Jurij

    2015-01-01

    Recently various pathways of human telomere (ht) DNA folding into G-quadruplexes and of ligand binding to these structures have been proposed. However, the key issue as to the nature of forces driving the folding and recognition processes remains unanswered. In this study, structural changes of 22-mer ht-DNA fragment (Tel22), induced by binding of ions (K+, Na+) and specific bisquinolinium ligands, were monitored by calorimetric and spectroscopic methods and by gel electrophoresis. Using the global model analysis of a wide variety of experimental data, we were able to characterize the thermodynamic forces that govern the formation of stable Tel22 G-quadruplexes, folding intermediates, and ligand-quadruplex complexes, and then predict Tel22 behavior in aqueous solutions as a function of temperature, salt concentration, and ligand concentration. On the basis of the above, we believe that our work sets the framework for better understanding the heterogeneity of ht-DNA folding and binding pathways, and its structural polymorphism. PMID:26083930

  15. The attenuation of the levitation force of HTS bulk exposed to AC magnetic field on the above NdFeB guideway

    NASA Astrophysics Data System (ADS)

    Liu, Minxian; Wang, Yan

    2012-01-01

    In the present High Temperature Superconducting (HTS) maglev vehicle system, the air gaps between the adjacent permanent magnets make the magnetic fields above the NdFeB guideway non-uniform. So it is required to study the characteristics of levitation force of the HTS bulk affected by the non-uniform applied magnetic fields along the moving direction. In this paper, we have studied the characteristics of the levitation force relaxation by an experiment in which AC magnetic field generated by an electromagnet is used to simulate the time-varying magnetic field caused by the inhomogeneity of the NdFeB guideway. From the experiment results, it is found that the levitation force is attenuated with the application of the AC field, and the attenuation is increased with the amplitude of the AC field, but the attenuation is almost independent of the frequency the AC magnetic field.

  16. Associated decrements in rate of force development and neural drive after maximal eccentric exercise.

    PubMed

    Farup, J; Rahbek, S K; Bjerre, J; de Paoli, F; Vissing, K

    2016-05-01

    The present study investigated the changes in contractile rate of force development (RFD) and the neural drive following a single bout of eccentric exercise. Twenty-four subjects performed 15 × 10 maximal isokinetic eccentric knee extensor contractions. Prior to and at 24, 48, 72, 96, and 168 h during post-exercise recovery, isometric RFD (30, 50 100, and 200 ms), normalized RFD [1/6,1/2, and 2/3 of maximal voluntary contraction (MVC)] and rate of electromyography rise (RER; 30, 50, and 75 ms) were measured. RFD decreased by 28-42% peaking at 48 h (P < 0.01-P < 0.001) and remained depressed at 168 h (P < 0.05). Normalized RFD at 2/3 of MVC decreased by 22-39% (P < 0.01), peaked at 72 h and returned to baseline at 168 h. These changes in RFD were associated with a decrease in RER at 48 h-96 h (P < 0.05-P < 0.001). Accumulated changes (area under curve) revealed a greater relative decrease in accumulated RFD at 100 ms by -2727 ± 309 (%h; P < 0.05) and 200 ms by -3035 ± 271 (%h; P < 0.001) compared with MVC, which decreased, by -1956 ± 234 (%h). In conclusion, RFD and RER are both markedly reduced following a bout of maximal eccentric exercise. This association suggests that exercise-induced decrements in RFD can, in part, be explained decrements in neural drive. PMID:25944178

  17. Thermal denaturation of Bungarus fasciatus acetylcholinesterase: Is aggregation a driving force in protein unfolding?

    PubMed

    Shin, I; Wachtel, E; Roth, E; Bon, C; Silman, I; Weiner, L

    2002-08-01

    A monomeric form of acetylcholinesterase from the venom of Bungarus fasciatus is converted to a partially unfolded molten globule species by thermal inactivation, and subsequently aggregates rapidly. To separate the kinetics of unfolding from those of aggregation, single molecules of the monomeric enzyme were encapsulated in reverse micelles of Brij 30 in 2,2,4-trimethylpentane, or in large unilamellar vesicles of egg lecithin/cholesterol at various protein/micelle (vesicle) ratios. The first-order rate constant for thermal inactivation at 45 degrees C, of single molecules entrapped within the reverse micelles (0.031 min(-1)), was higher than in aqueous solution (0.007 min(-1)) or in the presence of normal micelles (0.020 min(-1)). This clearly shows that aggregation does not provide the driving force for thermal inactivation of BfAChE. Within the large unilamellar vesicles, at average protein/vesicle ratios of 1:1 and 10:1, the first-order rate constants for thermal inactivation of the encapsulated monomeric acetylcholinesterase, at 53 degrees C, were 0.317 and 0.342 min(-1), respectively. A crosslinking technique, utilizing the photosensitive probe, hypericin, showed that thermal denaturation produces a distribution of species ranging from dimers through to large aggregates. Consequently, at a protein/vesicle ratio of 10:1, aggregation can occur upon thermal denaturation. Thus, these experiments also demonstrate that aggregation does not drive the thermal unfolding of Bungarus fasciatus acetylcholinesterase. Our experimental approach also permitted monitoring of recovery of enzymic activity after thermal denaturation in the absence of a competing aggregation process. Whereas no detectable recovery of enzymic activity could be observed in aqueous solution, up to 23% activity could be obtained for enzyme sequestered in the reverse micelles. PMID:12142456

  18. Nuclear Planetology: Constraining the Driving Force in Wegener's Continental Drift Theory

    NASA Astrophysics Data System (ADS)

    Roller, G.

    2015-12-01

    Nuclear planetology [1] is a new research field, which aims at deciphering the nuclear physics processes responsible for the evolution of ultra-substellar objects and the driving force in Wegener's continental drift theory by means of Re-Os nuclear geochronometry [2]. Terrestrial Re/Os ratios observed within diamond sulphide inclusions [3], compatible with lunar r-process production ratios of Th/U≈1≈Au/Ir [4], drop from ≈0.8 to 0.2-0.05 for nucleogeochronometric ages between 2.3 Ga and 1.4 Ga [5]. It has therefore been argued [5,6] that the Re/Os fractionation is related to a change in oxygen fugacity due to the physics/chemistry of Earth's core after a possibly Fermi-pressure controlled core collapse [4]. Here, Pd/Ru, Pd/Pt, Pd/Ir, Pd/Os, Ru/Ir, Ru/Os, Pt/Ir or Pt/Os ratios from 24 published H chondrite components [7] are connected to their respective nucleogeochronometric ages to constrain an extended fossil fractionation record over 800 Ma. The following ranges are obtained: 0.06-1.04 (Pd/Ru), 0.06-0.79 (Pd/Pt), 0.06-1.76 (Pd/Os), 0.07-1.94 (Pd/Ir), 1.08-1.99 (Ru/Ir), 0.83-2.41 (Pt/Os), 0.82-2.64 (Pt/Ir). Comparing the Re/Os fractionation pattern of the diamond sulphide inclusions with these results and considering that Re is readily oxidized even at ultra-low oxygen fugacity, it may be concluded that (i) extremely reducing conditions within Earth's core basically preserve any unfractionated r-process element ratio until today; and (ii) nuclear/quantum physics processes leading to the observed ratios and fractionation pattern are ultimately the driving force in Wegener's continental drift theory. [1] Roller (2015), Abstract T34B-0407, AGU Spring Meeting. [2] Roller (2015), Geophys. Res. Abstr. 17, EGU2015-17. [3] Smit et al. (2010), GCA 74, 3292. [4] Roller (2015), Abstract #5041, 78th Ann. Met. Soc. Meeting. [5] Roller (2015), Geophys. Res. Abstr. 17, EGU2015-2399. [6] Roller (2015), Abstract PG34A-0283, AGU Spring Meeting. [7] Horan et al. (2009), GCA 73

  19. Ozone stress as a driving force of sesquiterpene emissions: a suggested parameterization

    NASA Astrophysics Data System (ADS)

    Bourtsoukidis, E.; Bonn, B.; Dittmann, A.; Hakola, H.; Hellén, H.; Jacobi, S.

    2012-06-01

    Sesquiterpenes (C15H24) are semi-volatile organic compounds emitted by vegetation and are of interest in atmospheric research because they influence the oxidative capacity of the atmosphere and contribute to the formation of secondary organic aerosols. However, little is known about their emission pattern and no established parameterization is available for global emission models. The aim of this study is to investigate a Central European spruce forest and its emission response to meteorological and environmental parameters, looking for a parameterization that incorporates heat and oxidative stress as the main driving forces of the induced emissions. Therefore, a healthy ca. 80 yr old Norway spruce (Picea abies) tree was selected and a dynamical vegetation enclosure technique was applied from April to November 2011. The emissions clearly responded to temperature changes with small variations in the β-factor along the year (βspring=0.09 ± 0.01, βsummer=0.12 ± 0.02, βautumn=0.11 ± 0.02). However, daily calculated values revealed a vast amount of variability in temperature dependencies ((0.02 ± 0.002)< β<(0.27 ± 0.04)) with no distinct seasonality. By separating the complete dataset in 10 different ozone regimes, we found that in moderately or less polluted atmospheric conditions the main driving force of sesquiterpene emissions is the temperature, but when ambient ozone mixing ratios exceed a~critical threshold of (36.6 ± 3.9) ppbv, the emissions become primarily correlated with ozone. Considering the complete dataset, cross correlation analysis resulted in highest correlation with ambient ozone mixing ratios (CCO3=0.63 ± 0.01; CCT=0.47 ± 0.02 at t=0 h for temperature) with a time shift 2-4 h prior to the emissions. An only temperature dependent algorithm was found to substantially underestimate the induced emissions (20 % of the measured; R2=0.31). However, the addition of an ozone dependent term improved substantially the fitting between measured and

  20. Ozone stress as a driving force of sesquiterpene emissions: a suggested parameterisation

    NASA Astrophysics Data System (ADS)

    Bourtsoukidis, E.; Bonn, B.; Dittmann, A.; Hakola, H.; Hellén, H.; Jacobi, S.

    2012-11-01

    Sesquiterpenes (C15H24) are semi-volatile organic compounds emitted by vegetation and are of interest in atmospheric research because they influence the oxidative capacity of the atmosphere and contribute to the formation of secondary organic aerosols. However, little is known about their emission pattern and no established parameterisation is available for global emission models. The aim of this study is to investigate a Central European spruce forest and its emission response to meteorological and environmental parameters, looking for a parameterisation that incorporates heat and oxidative stress as the main driving forces of the induced emissions. Therefore, a healthy ca. 80 yr old Norway spruce (Picea abies) tree was selected and a dynamical vegetation enclosure technique was applied from April to November 2011. The emissions clearly responded to temperature changes with small variations in the β-factor along the year (βspring = 0.09 ± 0.01, βsummer = 0.12 ± 0.02, βautumn = 0.11 ± 0.02). However, daily calculated values revealed a vast amount of variability in temperature dependencies ((0.02 ± 0.002) < β < (0.27 ± 0.04)) with no distinct seasonality. By separating the complete dataset in 10 different ozone regimes, we found that in moderately or less polluted atmospheric conditions the main driving force of sesquiterpene emissions is the temperature, but when ambient ozone mixing ratios exceed a critical threshold of (36.6 ± 3.9) ppbv, the emissions become primarily correlated with ozone. Considering the complete dataset, cross correlation analysis resulted in highest correlation with ambient ozone mixing ratios (CCO3 = 0.63 ± 0.01; CCT = 0.47 ± 0.02 at t = 0 h for temperature) with a time shift 2-4 h prior to the emissions. An only temperature dependent algorithm was found to substantially underestimate the induced emissions (20% of the measured; R2 = 0.31). However, the addition of an ozone dependent term improved substantially the fitting

  1. Direct determination of the driving forces for taurocholate uptake into rat liver plasma membrane vesicles.

    PubMed

    Duffy, M C; Blitzer, B L; Boyer, J L

    1983-10-01

    To determine directly the driving forces for bile acid entry into the hepatocyte, the uptake of [3H]taurocholic acid into rat liver plasma membrane vesicles was studied. The membrane preparation contained predominantly right-side-out vesicles, and was highly enriched in plasma membrane marker enzymes. The uptake of taurocholate at equilibrium was inversely related to medium osmolarity, indicating transport into an osmotically sensitive space. In the presence of an inwardly directed sodium gradient (NaCl or sodium gluconate), the initial rate of uptake was rapid and taurocholate was transiently accumulated at a concentration twice that at equilibrium (overshoot). Other inwardly directed cation gradients (K+, Li+, choline+) or the presence of sodium in the absence of a gradient (Na+ equilibrated) resulted in a slower initial uptake rate and did not sustain an overshoot. Bile acids inhibited sodium-dependent taurocholate uptake, whereas bromsulphthalein inhibited both sodium-dependent and sodium-independent uptake and D-glucose had no effect on uptake. Uptake was temperature dependent, with maximal overshoots occurring at 25 degrees C. Imposition of a proton gradient across the vesicle (pHo less than pHi) in the absence of a sodium gradient failed to enhance taurocholate uptake, indicating that double ion exchange (Na+-H+, OH- -anion) is unlikely. Creation of a negative intravesicular potential by altering accompanying anions or by valinomycin-induced K+-diffusion potentials did not enhance taurocholate uptake, suggesting an electroneutral transport mechanism. The kinetics of taurocholate uptake demonstrated saturability with a Michaelis constant at 52 microM and maximum velocity of 4.5 nmol X mg-1 X protein X min-1. These studies provide definitive evidence for a sodium gradient-dependent, carrier-mediated, electrically neutral transport mechanism for hepatic taurocholate uptake. These findings are consistent with a model for bile secretion in which the basolateral

  2. Direct determination of the driving forces for taurocholate uptake into rat liver plasma membrane vesicles.

    PubMed Central

    Duffy, M C; Blitzer, B L; Boyer, J L

    1983-01-01

    To determine directly the driving forces for bile acid entry into the hepatocyte, the uptake of [3H]taurocholic acid into rat liver plasma membrane vesicles was studied. The membrane preparation contained predominantly right-side-out vesicles, and was highly enriched in plasma membrane marker enzymes. The uptake of taurocholate at equilibrium was inversely related to medium osmolarity, indicating transport into an osmotically sensitive space. In the presence of an inwardly directed sodium gradient (NaCl or sodium gluconate), the initial rate of uptake was rapid and taurocholate was transiently accumulated at a concentration twice that at equilibrium (overshoot). Other inwardly directed cation gradients (K+, Li+, choline+) or the presence of sodium in the absence of a gradient (Na+ equilibrated) resulted in a slower initial uptake rate and did not sustain an overshoot. Bile acids inhibited sodium-dependent taurocholate uptake, whereas bromsulphthalein inhibited both sodium-dependent and sodium-independent uptake and D-glucose had no effect on uptake. Uptake was temperature dependent, with maximal overshoots occurring at 25 degrees C. Imposition of a proton gradient across the vesicle (pHo less than pHi) in the absence of a sodium gradient failed to enhance taurocholate uptake, indicating that double ion exchange (Na+-H+, OH- -anion) is unlikely. Creation of a negative intravesicular potential by altering accompanying anions or by valinomycin-induced K+-diffusion potentials did not enhance taurocholate uptake, suggesting an electroneutral transport mechanism. The kinetics of taurocholate uptake demonstrated saturability with a Michaelis constant at 52 microM and maximum velocity of 4.5 nmol X mg-1 X protein X min-1. These studies provide definitive evidence for a sodium gradient-dependent, carrier-mediated, electrically neutral transport mechanism for hepatic taurocholate uptake. These findings are consistent with a model for bile secretion in which the basolateral

  3. Microstructure and mesh sensitivities of mesoscale surrogate driving force measures for transgranular fatigue cracks in polycrystals

    SciTech Connect

    Castelluccio, Gustavo M.; McDowell, David L.

    2015-05-22

    The number of cycles required to form and grow microstructurally small fatigue cracks in metals exhibits substantial variability, particularly for low applied strain amplitudes. This variability is commonly attributed to the heterogeneity of cyclic plastic deformation within the microstructure, and presents a challenge to minimum life design of fatigue resistant components. Our paper analyzes sources of variability that contribute to the driving force of transgranular fatigue cracks within nucleant grains. We also employ crystal plasticity finite element simulations that explicitly render the polycrystalline microstructure and Fatigue Indicator Parameters (FIPs) averaged over different volume sizes and shapes relative to the anticipated fatigue damage process zone. Volume averaging is necessary to both achieve description of a finite fatigue damage process zone and to regularize mesh dependence in simulations. Furthermore, results from constant amplitude remote applied straining are characterized in terms of the extreme value distributions of volume averaged FIPs. Grain averaged FIP values effectively mitigate mesh sensitivity, but they smear out variability within grains. Furthermore, volume averaging over bands that encompass critical transgranular slip planes appear to present the most attractive approach to mitigate mesh sensitivity while preserving variability within grains.

  4. Computational studies of sequence-specific driving forces in peptide self-assembly

    NASA Astrophysics Data System (ADS)

    Jeon, Joohyun

    Peptides are biopolymers made from various sequences of twenty different types of amino acids, connected by peptide bonds. There are practically an infinite number of possible sequences and tremendous possible combinations of peptide-peptide interactions. Recently, an increasing number of studies have shown a stark variety of peptide self-assembled nanomaterials whose detailed structures depend on their sequences and environmental factors; these have end uses in medical and bio-electronic applications, for example. To understand the underlying physics of complex peptide self-assembly processes and to delineate sequence specific effects, in this study, I use various simulation tools spanning all-atom molecular dynamics to simple lattice models and quantify the balance of interactions in the peptide self-assembly processes. In contrast to the existing view that peptides' aggregation propensities are proportional to the net sequence hydrophobicity and inversely proportional to the net charge, I show the more nuanced effects of electrostatic interactions, including the cooperative effects between hydrophobic and electrostatic interactions. Notably, I suggest rather unexpected, yet important roles of entropies in the small scale oligomerization processes. Overall, this study broadens our understanding of the role of thermodynamic driving forces in peptide self-assembly.

  5. [Landscape pattern change at the upper reaches of Minjiang River and its driving force].

    PubMed

    Hu, Zhibin; He, Xingyuan; Jiang, Xiaobo; Zhao, Yonghua; Hu, Yuanman; Chang, Yu; Li, Yuehui; Han, Wenquan; Liu, Miao

    2004-10-01

    The upper reaches of Minjiang River is an ecological sensitive and vulnerable area in southwest of China. It is of great significance to the ecological pattern safety in China. In this study, we analyzed the landscape pattern change through the interpretation of TM imageries in 1986, 1995 and 2000. The results showed that the matrix landscape in this area was grass landscape. Forest landscape patches were embedded in the grass landscape. The forest landscape area increased from 1986 to 1995 and decreased from 1995 to 2000. However, the number of patches of forest landscape was increasing during all the time. This suggested that the intensity of anthropogenic disturbances including harvesting, forest landscape reclaiming and excessive grazing were persistently increasing from 1986 to 2000. The ecological driving forces of the landscape change in this area were the intensified anthropogenic disturbances as a result of the population boom including the predacious harvesting of forest and excessive grazing. The natural disturbances such as the global climatic change also partly influenced the landscape change in this area. PMID:15624811

  6. Marine incursion into East Asia: a forgotten driving force of biodiversity

    PubMed Central

    Yang, Lu; Hou, Zhonge; Li, Shuqiang

    2013-01-01

    Episodic marine incursion has been a major driving force in the formation of present-day diversity. Marine incursion is considered to be one of the most productive ‘species pumps’ particularly because of its division and coalescence effects. Marine incursion events and their impacts on diversity are well documented from South America, North America and Africa; however, their history and impacts in continental East Asia largely remain unknown. Here, we propose a marine incursion scenario occurring in East Asia during the Miocene epoch, 10–17 Ma. Our molecular phylogenetic analysis of Platorchestia talitrids revealed that continental terrestrial populations (Platorchestia japonica) form a monophyletic group that is the sister group to the Northwest Pacific coastal species Platorchestia pacifica. The divergence time between the two species coincides with Middle Miocene high global sea levels. We suggest that the inland form arose as a consequence of a marine incursion event. This is the first solid case documenting the impact of marine incursion on extant biodiversity in continental East Asia. We believe that such incursion event has had major impacts on other organisms and has played an important role in the formation of biodiversity patterns in the region. PMID:23446524

  7. Whole-genome plasma sequencing reveals focal amplifications as a driving force in metastatic prostate cancer

    PubMed Central

    Ulz, Peter; Belic, Jelena; Graf, Ricarda; Auer, Martina; Lafer, Ingrid; Fischereder, Katja; Webersinke, Gerald; Pummer, Karl; Augustin, Herbert; Pichler, Martin; Hoefler, Gerald; Bauernhofer, Thomas; Geigl, Jochen B.; Heitzer, Ellen; Speicher, Michael R.

    2016-01-01

    Genomic alterations in metastatic prostate cancer remain incompletely characterized. Here we analyse 493 prostate cancer cases from the TCGA database and perform whole-genome plasma sequencing on 95 plasma samples derived from 43 patients with metastatic prostate cancer. From these samples, we identify established driver aberrations in a cancer-related gene in nearly all cases (97.7%), including driver gene fusions (TMPRSS2:ERG), driver focal deletions (PTEN, RYBP and SHQ1) and driver amplifications (AR and MYC). In serial plasma analyses, we observe changes in focal amplifications in 40% of cases. The mean time interval between new amplifications was 26.4 weeks (range: 5–52 weeks), suggesting that they represent rapid adaptations to selection pressure. An increase in neuron-specific enolase is accompanied by clonal pattern changes in the tumour genome, most consistent with subclonal diversification of the tumour. Our findings suggest a high plasticity of prostate cancer genomes with newly occurring focal amplifications as a driving force in progression. PMID:27328849

  8. Transcriptional abundance is not the single force driving the evolution of bacterial proteins

    PubMed Central

    2013-01-01

    Background Despite rapid progress in understanding the mechanisms that shape the evolution of proteins, the relative importance of various factors remain to be elucidated. In this study, we have assessed the effects of 16 different biological features on the evolutionary rates (ERs) of protein-coding sequences in bacterial genomes. Results Our analysis of 18 bacterial species revealed new correlations between ERs and constraining factors. Previous studies have suggested that transcriptional abundance overwhelmingly constrains the evolution of yeast protein sequences. This transcriptional abundance leads to selection against misfolding or misinteractions. In this study we found that there was no single factor in determining the evolution of bacterial proteins. Not only transcriptional abundance (codon adaptation index and expression level), but also protein-protein associations (PPAs), essentiality (ESS), subcellular localization of cytoplasmic membrane (SLM), transmembrane helices (TMH) and hydropathicity score (HS) independently and significantly affected the ERs of bacterial proteins. In some species, PPA and ESS demonstrate higher correlations with ER than transcriptional abundance. Conclusions Different forces drive the evolution of protein sequences in yeast and bacteria. In bacteria, the constraints are involved in avoiding a build-up of toxic molecules caused by misfolding/misinteraction (transcriptional abundance), while retaining important functions (ESS, PPA) and maintaining the cell membrane (SLM, TMH and HS). Each of these independently contributes to the variation in protein evolution. PMID:23914835

  9. Temporal-spatial patterns of wetlands changes in China and driving force analysis

    NASA Astrophysics Data System (ADS)

    Zhang, Shuwen; Zhang, Yangzhen; Chen, Jing; Zhang, Yanhong; Gao, Zhiqiang

    2004-11-01

    Wetlands are special ecosystem lying between the terrestrial and open-water areas. Similar to forest, grass, and ocean ecosystems, wetlands take parts in protecting environments and exploring resources. In China, wetlands are undergoing significant degradation that is caused by both natural processes and human activities. In order to know the details of wetlands change so as to take suitable actions to protect wetlands, Landsat TM/ETM images are used as main data sets. Accessorial data such as topography map and China mire map are also used. In this paper, wetlands are defined as swamplands, potholes, wet meadow, riverine, lacurtrine. Three periods (1990a, 1995a, 2000a) data of wetlands in china are extracted from TM through the interactive interpretation. Applying spatial analysis function of GIS technology and statistics methods, the spatial distribution pattern and temporal changes are studied. The research results show that, during the 10 years from 1990 to 2000, wetlands area decreased largely, and spatial difference is notable. Finally, the driving forces resulting in mires changes are analyzed.

  10. Microstructure and mesh sensitivities of mesoscale surrogate driving force measures for transgranular fatigue cracks in polycrystals

    DOE PAGESBeta

    Castelluccio, Gustavo M.; McDowell, David L.

    2015-05-22

    The number of cycles required to form and grow microstructurally small fatigue cracks in metals exhibits substantial variability, particularly for low applied strain amplitudes. This variability is commonly attributed to the heterogeneity of cyclic plastic deformation within the microstructure, and presents a challenge to minimum life design of fatigue resistant components. Our paper analyzes sources of variability that contribute to the driving force of transgranular fatigue cracks within nucleant grains. We also employ crystal plasticity finite element simulations that explicitly render the polycrystalline microstructure and Fatigue Indicator Parameters (FIPs) averaged over different volume sizes and shapes relative to the anticipatedmore » fatigue damage process zone. Volume averaging is necessary to both achieve description of a finite fatigue damage process zone and to regularize mesh dependence in simulations. Furthermore, results from constant amplitude remote applied straining are characterized in terms of the extreme value distributions of volume averaged FIPs. Grain averaged FIP values effectively mitigate mesh sensitivity, but they smear out variability within grains. Furthermore, volume averaging over bands that encompass critical transgranular slip planes appear to present the most attractive approach to mitigate mesh sensitivity while preserving variability within grains.« less

  11. Driving Forces for Oppositely Charged Polyion Association in Aqueous Solutions: Enthalpic, Entropic, but Not Electrostatic.

    PubMed

    Fu, Jingcheng; Schlenoff, Joseph B

    2016-01-27

    Driving forces for association between oppositely charged biological or synthetic polymers in aqueous solution have long been identified as electrostatic in origin. This attraction is broken down into an entropic component, due to loss of counterions, and an enthalpic component, stemming from Coulombic attraction between opposite charges. While the balance between entropic and enthalpic contributions shifts according to the conditions, the presence of exotherms or endotherms on mixing, though small, are viewed as signatures of Coulombic interactions which support theories of polyelectrolyte association rooted in continuum electrostatics. Here, a head-to-head comparison is made between mechanisms based on electrostatics and those based on specific ion pairing, or ion exchange. Using a Hofmeister series of counterions for a common polycation, poly(diallyldimethylammonium), enthalpy changes on association with poly(styrenesulfonate) are shown to derive from changes in water perturbation, revealed by Raman scattering studies of water O-H vibrations. The free energy for complexation is almost completely entropic over all salt concentrations. PMID:26771205

  12. Force Sensitive Handles and Capacitive Touch Sensor for Driving a Flexible Haptic-Based Immersive System

    PubMed Central

    Covarrubias, Mario; Bordegoni, Monica; Cugini, Umberto

    2013-01-01

    In this article, we present an approach that uses both two force sensitive handles (FSH) and a flexible capacitive touch sensor (FCTS) to drive a haptic-based immersive system. The immersive system has been developed as part of a multimodal interface for product design. The haptic interface consists of a strip that can be used by product designers to evaluate the quality of a 3D virtual shape by using touch, vision and hearing and, also, to interactively change the shape of the virtual object. Specifically, the user interacts with the FSH to move the virtual object and to appropriately position the haptic interface for retrieving the six degrees of freedom required for both manipulation and modification modalities. The FCTS allows the system to track the movement and position of the user's fingers on the strip, which is used for rendering visual and sound feedback. Two evaluation experiments are described, which involve both the evaluation and the modification of a 3D shape. Results show that the use of the haptic strip for the evaluation of aesthetic shapes is effective and supports product designers in the appreciation of the aesthetic qualities of the shape. PMID:24113680

  13. Stress-triggered atavistic reprogramming (STAR) addiction: driving force behind head and neck cancer?

    PubMed Central

    Masuda, Muneyuki; Wakasaki, Takahiro; Toh, Satoshi

    2016-01-01

    Recent results of the Cancer Genome Atlas on head and neck squamous cell carcinoma (HNSCC) revealed that HNSCC lacked predominant gain-of-function mutations in oncogenes, whereas an essential role for epigenetics in oncogenesis has become apparent. In parallel, it has gained general acceptance that cancer is considered as complex adaptive system, which evolves responding environmental selective pressures. This somatic evolution appears to proceed concurrently with the acquisition of an atavistic pluripotent state (i.e., “stemness”), which is inducible by intrinsic epigenetic reprogramming program as demonstrated by induced pluripotent stem (iPS) cells. This Nobel prize-winning discovery has markedly accelerated and expanded cancer stem cell research from the point of epigenetic reprogramming. Taken together, we hypothesize that stress-triggered atavistic reprogramming (STAR) may be the major driving force of HNSCC evolution. In this perspective, we discuss the possible mechanisms of STAR in HNSCC, focusing on recent topics of epigenetic reprogramming in developmental and cancer cell biology. PMID:27429838

  14. Driving force transmission mechanism using a timing belt for an internal combustion engine

    SciTech Connect

    Abe, S.

    1987-11-24

    A driving force transmission mechanism is described comprising: a timing pulley having teeth, each of the teeth having a width perpendicular to a direction of movement of the teeth; and a timing belt engaging the timing pulley, the timing belt having teeth, each of the timing belt teeth having a width perpendicular to a direction of movement of the timing belt teeth; a width of the timing belt not being larger that a width of the timing pulley; the width of the teeth of the timing belt at dedendums of the teeth being larger than a width of engagement of the teeth of the timing belt with the teeth of the timing pulley; at least one of width end portions of the teeth of the timing pulley and width end portions of the teeth of the timing belt being cut out so that width end portions of the teeth of the timing belt at dedendums of the timing belt do not contact the teeth of the timing pulley.

  15. Driving force for indentation cracking in glass: composition, pressure and temperature dependence

    PubMed Central

    Rouxel, Tanguy

    2015-01-01

    The occurrence of damage at the surface of glass parts caused by sharp contact loading is a major issue for glass makers, suppliers and end-users. Yet, it is still a poorly understood problem from the viewpoints both of glass science and solid mechanics. Different microcracking patterns are observed at indentation sites depending on the glass composition and indentation cracks may form during both the loading and the unloading stages. Besides, we do not know much about the fracture toughness of glass and its composition dependence, so that setting a criterion for crack initiation and predicting the extent of the damage yet remain out of reach. In this study, by comparison of the behaviour of glasses from very different chemical systems and by identifying experimentally the individual contributions of the different rheological processes leading to the formation of the imprint—namely elasticity, densification and shear flow—we obtain a fairly straightforward prediction of the type and extent of the microcracks which will most likely form, depending on the physical properties of the glass. Finally, some guidelines to reduce the driving force for microcracking are proposed in the light of the effects of composition, temperature and pressure, and the areas for further research are briefly discussed. PMID:25713446

  16. Whole-genome plasma sequencing reveals focal amplifications as a driving force in metastatic prostate cancer.

    PubMed

    Ulz, Peter; Belic, Jelena; Graf, Ricarda; Auer, Martina; Lafer, Ingrid; Fischereder, Katja; Webersinke, Gerald; Pummer, Karl; Augustin, Herbert; Pichler, Martin; Hoefler, Gerald; Bauernhofer, Thomas; Geigl, Jochen B; Heitzer, Ellen; Speicher, Michael R

    2016-01-01

    Genomic alterations in metastatic prostate cancer remain incompletely characterized. Here we analyse 493 prostate cancer cases from the TCGA database and perform whole-genome plasma sequencing on 95 plasma samples derived from 43 patients with metastatic prostate cancer. From these samples, we identify established driver aberrations in a cancer-related gene in nearly all cases (97.7%), including driver gene fusions (TMPRSS2:ERG), driver focal deletions (PTEN, RYBP and SHQ1) and driver amplifications (AR and MYC). In serial plasma analyses, we observe changes in focal amplifications in 40% of cases. The mean time interval between new amplifications was 26.4 weeks (range: 5-52 weeks), suggesting that they represent rapid adaptations to selection pressure. An increase in neuron-specific enolase is accompanied by clonal pattern changes in the tumour genome, most consistent with subclonal diversification of the tumour. Our findings suggest a high plasticity of prostate cancer genomes with newly occurring focal amplifications as a driving force in progression. PMID:27328849

  17. Investigation of the stability of AC repulsive force levitation systems for low-speed maglev.

    SciTech Connect

    He, J. L.; Wang, Z.; Rote, D. M.; Winkelman, S.; Energy Systems

    1992-09-01

    Discusses the stability of an AC induction levitation system, focusing on the analysis and optimum design of the secondary conductor. Several improved secondary conductor geometries are considered. A theoretical model with numerical results, as well as experimental observations and data are presented. Theoretical and experimental results indicate that only marginal stability can be achieved with a single-plate secondary conductor. Modifications of the single plate can enhance its stability at rest, but this design suffers from longitudinal instabilities when propelled. It is concluded that a double-plate secondary conductor is stable in all six degrees of freedom.

  18. Modeling and damping of high-frequency leakage currents in PWM inverter-fed AC motor drive systems

    SciTech Connect

    Ogasawara, Satoshi; Akagi, Hirofumi

    1995-12-31

    This paper presents an equivalent circuit for high-frequency leakage currents in PWM inverter-fed ac motors, which forms a series resonant circuit. The analysis based on the equivalent circuit leads to such a conclusion that the connection of a conventional common-mode choke or reactor in series between the ac terminals of a PWM inverter and those of an ac motor is not effective to reduce the rms and average values of the leakage current, but effective to reduce the peak value. Furthermore, this paper proposes a common-mode transformer which is different in damping principle from the conventional common-mode choke. It is shown theoretically and experimentally that the common-mode transformer is able to reduce the rms value of the leakage current to 25%, where the core used in the common-mode transformer is smaller than that of the conventional common-mode choke.

  19. Growth of whiskers from Sn surfaces: Driving forces and growth mechanisms

    NASA Astrophysics Data System (ADS)

    Chason, Eric; Jadhav, Nitin; Pei, Fei; Buchovecky, Eric; Bower, Allan

    2013-05-01

    Sn whiskers are thin filaments that grow spontaneously out of the surface of coatings on Cu and have become a critical reliability problem in Pb-free electronics. In this review, we focus on what creates the driving force for whiskers (or more rounded “hillocks”), and what determines where on the surface they will form. Experimental studies are reviewed that quantify the relationship between the Cu-Sn intermetallic (IMC) formation, stress in the layer and whisker/hillock density. Measurements of the mechanical properties show how stress relaxation in the Sn layer is intimately related to how much stress develops due to the IMC formation. Real-time scanning electron microscope (SEM)/focused ion beam (FIB) studies are described that illustrate the whisker/hillock growth process in detail. Whiskers are found to grow out of a single grain on the surface with little lateral growth while hillock growth is accompanied by extensive grain growth and crystallite rotation. Electron-backscattering detection (EBSD) shows the grain structure around where the whiskers/hillocks form, indicating that whiskers can grow out of pre-existing grains and do not require the nucleation of new grains. This has led to a picture in which stress builds up due to IMC growth and causes whiskers/hillocks to form at “weak grains”, i.e., grains that have a stress relaxation mechanism that becomes active at a lower stress than its neighbors. FEA (finite element analysis) calculations are used to simulate the evolving stress and whisker growth for several different mechanisms that may lead to “weak” grains.

  20. How metal films de-wet substrates : identifying the kinetic pathways and energetic driving forces.

    SciTech Connect

    Thurmer, Konrad; Schmid, Andreas; Sato, Yu; Hamilton, John C.; Saa, Angela; McCarty, Kevin F.; de la Figuera, Juan; Bartelt, Norman Charles

    2008-10-01

    We study how single-crystal chromium films of uniform thickness on W(110) substrates are converted to arrays of three-dimensional (3D) Cr islands during annealing. We use low-energy electron microscopy (LEEM) to directly observe a kinetic pathway that produces trenches that expose the wetting layer. Adjacent film steps move simultaneously uphill and downhill relative to the staircase of atomic steps on the substrate. This step motion thickens the film regions where steps advance. Where film steps retract, the film thins, eventually exposing the stable wetting layer. Since our analysis shows that thick Cr films have a lattice constant close to bulk Cr, we propose that surface and interface stress provide a possible driving force for the observed morphological instability. Atomistic simulations and analytic elastic models show that surface and interface stress can cause a dependence of film energy on thickness that leads to an instability to simultaneous thinning and thickening. We observe that de-wetting is also initiated at bunches of substrate steps in two other systems, Ag/W(110) and Ag/Ru(0001). We additionally describe how Cr films are converted into patterns of unidirectional stripes as the trenches that expose the wetting layer lengthen along the W[001] direction. Finally, we observe how 3D Cr islands form directly during film growth at elevated temperature. The Cr mesas (wedges) form as Cr film steps advance down the staircase of substrate steps, another example of the critical role that substrate steps play in 3D island formation.

  1. Crop modeling: Studying the effect of water stress on the driving forces governing plant water potential

    NASA Astrophysics Data System (ADS)

    van Emmerik, T. H. M.; Mirfenderesgi, G.; Bohrer, G.; Steele-Dunne, S. C.; Van De Giesen, N.

    2015-12-01

    Water stress is one of the most important environmental factors that influence plant water dynamics. To prevent excessive water loss and physiological damage, plants can regulate transpiration by adjusting the stomatal aperture. This enhances survival, but also reduced photosynthesis and productivity. During periods of low water availability, stomatal regulation is a trade-off between optimization of either survival or production. Water stress defence mechanisms lead to significant changes in plant dynamics, e.g. leaf and stem water content. Recent research has shown that water content in a corn canopy can change up to 30% diurnally as a result of water stress, which has a considerable influence on radar backscatter from a corn canopy [1]. This highlighted the potential of water stress detection using radar. To fully explore the potential of water stress monitoring using radar, we need to understand the driving forces governing plant water potential. For this study, the recently developed the Finite-Element Tree-Crown Hydrodynamic model version 2 (FETCH2) model is applied to a corn canopy. FETCH2 is developed to resolve the hydrodynamic processes within a plant using the porous media analogy, allowing investigation of the influence of environmental stress factors on plant dynamics such as transpiration, photosynthesis, stomatal conductance, and leaf and stem water content. The model is parameterized and evaluated using a detailed dataset obtained during a three-month field experiment in Flevoland, the Netherlands, on a corn canopy. [1] van Emmerik, T., S. Steele-Dunne, J. Judge and N. van de Giesen: "Impact of Diurnal Variation in Vegetation Water Content on Radar Backscatter of Maize During Water Stress", Geosciences and Remote Sensing, IEEE Transactions on, vol. 52, issue 7, doi: 10.1109/TGRS.2014.2386142, 2015.

  2. Driving forces of heavy metal changes in agricultural soils in a typical manufacturing center.

    PubMed

    Qiu, Menglong; Li, Fangbai; Wang, Qi; Chen, Junjian; Yang, Guoyi; Liu, Liming

    2015-05-01

    Heavy metal concentrations in 2002 and 2012 in agricultural soils in Dongguan, a manufacturing center in southern China, were analyzed to determine the impact of rapid economic development on soil pollution. The level of pollution was assessed using the Nemerow synthetic pollution index (NPI), and its changing characteristics and driving forces were analyzed using multivariate statistical and geostatistical methods. The results indicate that the mean NPI was 0.79 in 2002 and 0.84 in 2012, which indicates aggravated heavy metal contamination in the agricultural soils. The concentrations of Cd and Zn increased 54.7 and 20.8 %, respectively, whereas Hg and Pb decreased 35.3 and 24.5 %, respectively. Cr, As, Cu, and Ni remained relatively stable. The Hg and Cd concentrations were highly correlated with soil types (P < 0.01), the secondary industrial output per unit of land (P < 0.01), proportion of cereal fields (P < 0.01), proportion of vegetable fields (P < 0.01), population density (P < 0.05), and road density (P < 0.05). The Pb and As concentrations were greatly influenced by soil types (P < 0.01), river density (P < 0.01), fertilizer rate (P < 0.01), and road density (P < 0.05). Cr, Zn, Cu, and Ni concentrations were primarily driven by soil types (P < 0.01), river density (P < 0.01), and fertilizer rate (P < 0.05). PMID:25861902

  3. Detailed Per-residue Energetic Analysis Explains the Driving Force for Microtubule Disassembly

    PubMed Central

    Ayoub, Ahmed T.; Klobukowski, Mariusz; Tuszynski, Jack A.

    2015-01-01

    Microtubules are long filamentous hollow cylinders whose surfaces form lattice structures of αβ-tubulin heterodimers. They perform multiple physiological roles in eukaryotic cells and are targets for therapeutic interventions. In our study, we carried out all-atom molecular dynamics simulations for arbitrarily long microtubules that have either GDP or GTP molecules in the E-site of β-tubulin. A detailed energy balance of the MM/GBSA inter-dimer interaction energy per residue contributing to the overall lateral and longitudinal structural stability was performed. The obtained results identified the key residues and tubulin domains according to their energetic contributions. They also identified the molecular forces that drive microtubule disassembly. At the tip of the plus end of the microtubule, the uneven distribution of longitudinal interaction energies within a protofilament generates a torque that bends tubulin outwardly with respect to the cylinder's axis causing disassembly. In the presence of GTP, this torque is opposed by lateral interactions that prevent outward curling, thus stabilizing the whole microtubule. Once GTP hydrolysis reaches the tip of the microtubule (lateral cap), lateral interactions become much weaker, allowing tubulin dimers to bend outwards, causing disassembly. The role of magnesium in the process of outward curling has also been demonstrated. This study also showed that the microtubule seam is the most energetically labile inter-dimer interface and could serve as a trigger point for disassembly. Based on a detailed balance of the energetic contributions per amino acid residue in the microtubule, numerous other analyses could be performed to give additional insights into the properties of microtubule dynamic instability. PMID:26030285

  4. Oxidized cholesterol as the driving force behind the development of Alzheimer’s disease

    PubMed Central

    Gamba, Paola; Testa, Gabriella; Gargiulo, Simona; Staurenghi, Erica; Poli, Giuseppe; Leonarduzzi, Gabriella

    2015-01-01

    Alzheimer’s disease (AD), the most common neurodegenerative disorder associated with dementia, is typified by the pathological accumulation of amyloid Aβ peptides and neurofibrillary tangles (NFT) within the brain. Considerable evidence indicates that many events contribute to AD progression, including oxidative stress, inflammation, and altered cholesterol metabolism. The brain’s high lipid content makes it particularly vulnerable to oxidative species, with the consequent enhancement of lipid peroxidation and cholesterol oxidation, and the subsequent formation of end products, mainly 4-hydroxynonenal and oxysterols, respectively from the two processes. The chronic inflammatory events observed in the AD brain include activation of microglia and astrocytes, together with enhancement of inflammatory molecule and free radical release. Along with glial cells, neurons themselves have been found to contribute to neuroinflammation in the AD brain, by serving as sources of inflammatory mediators. Oxidative stress is intimately associated with neuroinflammation, and a vicious circle has been found to connect oxidative stress and inflammation in AD. Alongside oxidative stress and inflammation, altered cholesterol metabolism and hypercholesterolemia also significantly contribute to neuronal damage and to progression of AD. Increasing evidence is now consolidating the hypothesis that oxidized cholesterol is the driving force behind the development of AD, and that oxysterols are the link connecting the disease to altered cholesterol metabolism in the brain and hypercholesterolemia; this is because of the ability of oxysterols, unlike cholesterol, to cross the blood brain barrier (BBB). The key role of oxysterols in AD pathogenesis has been strongly supported by research pointing to their involvement in modulating neuroinflammation, Aβ accumulation, and cell death. This review highlights the key role played by cholesterol and oxysterols in the brain in AD pathogenesis

  5. Quantitatively probing the magnetic behavior of individual nanoparticles by an AC field-modulated magnetic force microscopy.

    PubMed

    Li, Xiang; Lu, Wei; Song, Yiming; Wang, Yuxin; Chen, Aiying; Yan, Biao; Yoshimura, Satoru; Saito, Hitoshi

    2016-01-01

    Despite decades of advances in magnetic imaging, obtaining direct, quantitative information with nanometer scale spatial resolution remains an outstanding challenge. Current approaches, for example, Hall micromagnetometer and nitrogen-vacancy magnetometer, are limited by highly complex experimental apparatus and a dedicated sample preparation process. Here we present a new AC field-modulated magnetic force microscopy (MFM) and report the local and quantitative measurements of the magnetic information of individual magnetic nanoparticles (MNPs), which is one of the most iconic objects of nanomagnetism. This technique provides simultaneously a direct visualization of the magnetization process of the individual MNPs, with spatial resolution and magnetic sensitivity of about 4.8 nm and 1.85 × 10(-20) A m(2), respectively, enabling us to separately estimate the distributions of the dipolar fields and the local switching fields of individual MNPs. Moreover, we demonstrate that quantitative magnetization moment of individual MNPs can be routinely obtained using MFM signals. Therefore, it underscores the power of the AC field-modulated MFM for biological and biomedical applications of MNPs and opens up the possibility for directly and quantitatively probing the weak magnetic stray fields from nanoscale magnetic systems with superior spatial resolution. PMID:26932357

  6. Quantitatively probing the magnetic behavior of individual nanoparticles by an AC field-modulated magnetic force microscopy

    PubMed Central

    Li, Xiang; Lu, Wei; Song, Yiming; Wang, Yuxin; Chen, Aiying; Yan, Biao; Yoshimura, Satoru; Saito, Hitoshi

    2016-01-01

    Despite decades of advances in magnetic imaging, obtaining direct, quantitative information with nanometer scale spatial resolution remains an outstanding challenge. Current approaches, for example, Hall micromagnetometer and nitrogen-vacancy magnetometer, are limited by highly complex experimental apparatus and a dedicated sample preparation process. Here we present a new AC field-modulated magnetic force microscopy (MFM) and report the local and quantitative measurements of the magnetic information of individual magnetic nanoparticles (MNPs), which is one of the most iconic objects of nanomagnetism. This technique provides simultaneously a direct visualization of the magnetization process of the individual MNPs, with spatial resolution and magnetic sensitivity of about 4.8 nm and 1.85 × 10−20 A m2, respectively, enabling us to separately estimate the distributions of the dipolar fields and the local switching fields of individual MNPs. Moreover, we demonstrate that quantitative magnetization moment of individual MNPs can be routinely obtained using MFM signals. Therefore, it underscores the power of the AC field-modulated MFM for biological and biomedical applications of MNPs and opens up the possibility for directly and quantitatively probing the weak magnetic stray fields from nanoscale magnetic systems with superior spatial resolution. PMID:26932357

  7. Quantitatively probing the magnetic behavior of individual nanoparticles by an AC field-modulated magnetic force microscopy

    NASA Astrophysics Data System (ADS)

    Li, Xiang; Lu, Wei; Song, Yiming; Wang, Yuxin; Chen, Aiying; Yan, Biao; Yoshimura, Satoru; Saito, Hitoshi

    2016-03-01

    Despite decades of advances in magnetic imaging, obtaining direct, quantitative information with nanometer scale spatial resolution remains an outstanding challenge. Current approaches, for example, Hall micromagnetometer and nitrogen-vacancy magnetometer, are limited by highly complex experimental apparatus and a dedicated sample preparation process. Here we present a new AC field-modulated magnetic force microscopy (MFM) and report the local and quantitative measurements of the magnetic information of individual magnetic nanoparticles (MNPs), which is one of the most iconic objects of nanomagnetism. This technique provides simultaneously a direct visualization of the magnetization process of the individual MNPs, with spatial resolution and magnetic sensitivity of about 4.8 nm and 1.85 × 10-20 A m2, respectively, enabling us to separately estimate the distributions of the dipolar fields and the local switching fields of individual MNPs. Moreover, we demonstrate that quantitative magnetization moment of individual MNPs can be routinely obtained using MFM signals. Therefore, it underscores the power of the AC field-modulated MFM for biological and biomedical applications of MNPs and opens up the possibility for directly and quantitatively probing the weak magnetic stray fields from nanoscale magnetic systems with superior spatial resolution.

  8. Kinesin-2 KIF3AC and KIF3AB Can Drive Long-Range Transport along Microtubules.

    PubMed

    Guzik-Lendrum, Stephanie; Rank, Katherine C; Bensel, Brandon M; Taylor, Keenan C; Rayment, Ivan; Gilbert, Susan P

    2015-10-01

    Mammalian KIF3AC is classified as a heterotrimeric kinesin-2 that is best known for organelle transport in neurons, yet in vitro studies to characterize its single molecule behavior are lacking. The results presented show that a KIF3AC motor that includes the native helix α7 sequence for coiled-coil formation is highly processive with run lengths of ∼1.23 μm and matching those exhibited by conventional kinesin-1. This result was unexpected because KIF3AC exhibits the canonical kinesin-2 neck-linker sequence that has been reported to be responsible for shorter run lengths observed for another heterotrimeric kinesin-2, KIF3AB. However, KIF3AB with its native neck linker and helix α7 is also highly processive with run lengths of ∼1.62 μm and exceeding those of KIF3AC and kinesin-1. Loop L11, a component of the microtubule-motor interface and implicated in activating ADP release upon microtubule collision, is significantly extended in KIF3C as compared with other kinesins. A KIF3AC encoding a truncation in KIF3C loop L11 (KIF3ACΔL11) exhibited longer run lengths at ∼1.55 μm than wild-type KIF3AC and were more similar to KIF3AB run lengths, suggesting that L11 also contributes to tuning motor processivity. The steady-state ATPase results show that shortening L11 does not alter kcat, consistent with the observation that single molecule velocities are not affected by this truncation. However, shortening loop L11 of KIF3C significantly increases the microtubule affinity of KIF3ACΔL11, revealing another structural and mechanistic property that can modulate processivity. The results presented provide new, to our knowledge, insights to understand structure-function relationships governing processivity and a better understanding of the potential of KIF3AC for long-distance transport in neurons. PMID:26445448

  9. Influence of Critical Current Density on Guidance Force Decay of HTS Bulk Exposed to AC Magnetic Field Perturbation in a Maglev Vehicle System

    NASA Astrophysics Data System (ADS)

    Longcai, Zhang; Jianguo, Kong

    2012-07-01

    Superconducting maglev vehicle is one of the most promising applications of HTS bulks. In such a system, the HTS bulks are always exposed to AC external magnetic field, which is generated by the inhomogeneous surface magnetic field of the NdFeB guideway. In our previous work, we studied the guidance force decay of the YBCO bulk over the NdFdB guideway used in the High-temperature superconducting maglev vehicle system with the application of the AC external magnetic field, and calculated the guidance force decay as a function of time based on an analytic model. In this paper, we investigated the influence of the critical current density on the guidance force decay of HTS bulk exposed to AC field perturbation in the maglev vehicle system and try to adopt a method to suppress the decay. From the results, it was found that the guidance force decay rate was higher for the bulk with lower critical current density. Therefore, we could suppress the guidance force decay of HTS bulk exposed to AC external magnetic field perturbation in the maglev vehicle system by improving critical current density of the bulk.

  10. Inertial force measurement of an actuator arm of a hard disk drive in free oscillation by numerical analysis and experiments

    NASA Astrophysics Data System (ADS)

    Gu, Bin; Shu, Dong-Wei; Fujii, Yusaku; Shi, Bao-Jun

    2008-12-01

    In this paper, inertial force of an Actuator Arm of a Hard Disk Drive (HDD) in free oscillation after an impact load is accurately measured by means of a finite element analysis and by carrying out experiments using a modified Levitation Mass Method (LMM). A 3D finite element model of an actuator arm of a HDD is modeled in ANSYS/LS-DYNA using shell elements. An impact load, which is modeled as a half sine force pulse, is applied to a mass, which is attached with the Actuator Arm. The velocity and the inertial force of the mass in free oscillation are obtained from the simulation. In the LMM method, the arm is attached to a mass, i.e. the moving part of an aerostatic linear bearing, and the total force acting on the mass is measured as the inertial force of the mass using an optical interferometer. An impact is applied to the mass with the arm by colliding it to the metal base, and the inertial force of the arm is evaluated during the free oscillation. The velocity and the inertial force of the mass are calculated from the measured time-varying Doppler frequency shift. A good correlation between the experimental and numerical results is achieved. This numerical analysis can be further used to investigate the dynamic response of the actuator arm when it is subjected to different impact load, which is modeled with half sine force pulse with different pulse widths and amplitudes.

  11. Sector trends and driving forces of global energy use and greenhouse gas emissions: focus in industry and buildings

    SciTech Connect

    Price, Lynn; Worrell, Ernst; Khrushch, Marta

    1999-09-01

    Disaggregation of sectoral energy use and greenhouse gas emissions trends reveals striking differences between sectors and regions of the world. Understanding key driving forces in the energy end-use sectors provides insights for development of projections of future greenhouse gas emissions. This report examines global and regional historical trends in energy use and carbon emissions in the industrial, buildings, transport, and agriculture sectors, with a more detailed focus on industry and buildings. Activity and economic drivers as well as trends in energy and carbon intensity are evaluated. The authors show that macro-economic indicators, such as GDP, are insufficient for comprehending trends and driving forces at the sectoral level. These indicators need to be supplemented with sector-specific information for a more complete understanding of future energy use and greenhouse gas emissions.

  12. Passive Joint Forces Are Tuned to Limb Use in Insects and Drive Movements without Motor Activity

    PubMed Central

    Ache, Jan M.; Matheson, Thomas

    2013-01-01

    Summary Background Limb movements are generally driven by active muscular contractions working with and against passive forces arising in muscles and other structures. In relatively heavy limbs, the effects of gravity and inertia predominate, whereas in lighter limbs, passive forces intrinsic to the limb are of greater consequence. The roles of passive forces generated by muscles and tendons are well understood, but there has been little recognition that forces originating within joints themselves may also be important, and less still that these joint forces may be adapted through evolution to complement active muscle forces acting at the same joint. Results We examined the roles of passive joint forces in insect legs with different arrangements of antagonist muscles. We first show that passive forces modify actively generated movements of a joint across its working range, and that they can be sufficiently strong to generate completely passive movements that are faster than active movements observed in natural behaviors. We further demonstrate that some of these forces originate within the joint itself. In legs of different species adapted to different uses (walking, jumping), these passive joint forces complement the balance of strength of the antagonist muscles acting on the joint. We show that passive joint forces are stronger where they assist the weaker of two antagonist muscles. Conclusions In limbs where the dictates of a key behavior produce asymmetry in muscle forces, passive joint forces can be coadapted to provide the balance needed for the effective generation of other behaviors. PMID:23871240

  13. The Labour Market as the Driving Force of Belgian Higher Education.

    ERIC Educational Resources Information Center

    Wielemans, Willy

    1988-01-01

    An examination of internal and external forces on Belgian higher education suggests that the system is too closely controlled by economic and political forces in the labor market, which threatens to distort university life and higher education in general. (MSE)

  14. Economy, Speed and Size Matter: Evolutionary Forces Driving Nuclear Genome Miniaturization and Expansion

    PubMed Central

    CAVALIER-SMITH, THOMAS

    2005-01-01

    • Background Nuclear genome size varies 300 000-fold, whereas transcriptome size varies merely 17-fold. In the largest genomes nearly all DNA is non-genic secondary DNA, mostly intergenic but also within introns. There is now compelling evidence that secondary DNA is functional, i.e. positively selected by organismal selection, not the purely neutral or ‘selfish’ outcome of mutation pressure. The skeletal DNA theory argued that nuclear volumes are genetically determined primarily by nuclear DNA amounts, modulated somewhat by genes affecting the degree of DNA packing or unfolding; the huge spread of nuclear genome sizes is the necessary consequence of the origin of the nuclear envelope and the nucleation of its assembly by DNA, plus the adaptively significant 300 000-fold range of cell volumes and selection for balanced growth by optimizing karyoplasmic volume ratios (essentially invariant with cell volume in growing/multiplying cells). This simple explanation of the C-value paradox is refined here in the light of new insights into the nature of heterochromatin and the nuclear lamina, the genetic control of cell volume, and large-scale eukaryote phylogeny, placing special emphasis on protist test cases of the basic principles of nuclear genome size evolution. • Genome Miniaturization and Expansion Intracellular parasites (e.g. Plasmodium, microsporidia) dwarfed their genomes by gene loss and eliminating virtually all secondary DNA. The primary driving forces for genome reduction are metabolic and spatial economy and cell multiplication speed. Most extreme nuclear shrinkage yielded genomes as tiny as 0·38 Mb (making the nuclear genome size range effectively 1·8 million-fold!) in some minute enslaved nuclei (nucleomorphs) of cryptomonads and chlorarachneans, chimaeric cells that also retain a separate normal large nucleus. The latter shows typical correlation between genome size and cell volume, but nucleomorphs do not despite co-existing in the same cell

  15. The Driving Force of the Na+/Ca2+-Exchanger during Metabolic Inhibition

    PubMed Central

    Baartscheer, Antonius; Schumacher, Cees A.; Coronel, Ruben; Fiolet, Jan W. T.

    2011-01-01

    Objective: Metabolic inhibition causes a decline in mechanical performance and, if prolonged, myocardial contracture and cell death. The decline in mechanical performance is mainly due to altered intracellular calcium handling, which is under control of the Na+/Ca2+-exchanger (NCX) The driving force of the NCX (ΔGncx) determines the activity of NCX. The aim of this study was to describe the relation between ΔGncx and calcium homeostasis during metabolic inhibition. Methods: In left ventricular rabbit myocytes, during metabolic inhibition (2 mmol/L sodium cyanide), sodium ([Na+]i), calcium ([Ca2+;]i), and action potentials were determined with SBFI, indo-1, and the patch clamp technique. Changes of ΔGncx were calculated. Results: During metabolic inhibition: The first 8 min [Na+]i remained constant, systolic calcium decreased from 532 ± 28 to 82 ± 13 nM, diastolic calcium decreased from 121 ± 12 to 36 ± 10 nM and the sarcoplasmic reticulum (SR) calcium content was depleted for 85 ± 3%. After 8 min [Na+;]i and diastolic calcium started to increase to 30 ± 1.3 mmol/L and 500 ± 31 nM after 30 min respectively. The action potential duration shortened biphasically. In the first 5 min it shortened from 225 ± 12 to 153 ± 11 ms and remained almost constant until it shortened again after 10 min. After 14 min action potential and calcium transients disappeared due to unexcitability of the myocytes. This resulted in an increased of the time average of ΔGncx from 6.2 ± 0.2 to 7.7 ± 0.3 kJ/mol during the first 3 min, where after it decreased and became negative after about 15 min. Conclusion: Metabolic inhibition caused an early increase of ΔGncx caused by shortening of the action potential. The increase of ΔGncx contributed to decrease of diastolic calcium, calcium transient amplitude, SR calcium content, and contractility. The increase of diastolic calcium started after ΔGncx became

  16. Reduction of Common-Mode Conducted Noise Emissions in PWM Inverter-fed AC Motor Drive Systems using Optimized Passive EMI Filter

    NASA Astrophysics Data System (ADS)

    Jettanasen, C.; Ngaopitakkul, A.

    2010-10-01

    Conducted electromagnetic interference (EMI) generated by PWM inverter-fed induction motor drive systems, which are currently widely used in many industrial and/or avionic applications, causes severe parasitic current problems, especially at high frequencies (HF). These restrict power electronic drive's evolution. In order to reduce or minimize these EMI problems, several techniques can be applied. In this paper, insertion of an optimized passive EMI filter is proposed. This filter is optimized by taking into account real impedances of each part of a considered AC motor drive system contrarily to commercial EMI filters designed by considering internal impedance of disturbance source and load, equal to 50Ω. Employing the latter EMI filter would make EMI minimization less effective. The proposed EMI filter optimization is mainly dedicated to minimize common mode (CM) currents due to its most dominant effects in this kind of system. The efficiency of the proposed optimization method using two-port network approach is deduced by comparing the minimized CM current spectra to an applied normative level (ex. DO-160D in aeronautics).

  17. MRCK-1 Drives Apical Constriction in C. elegans by Linking Developmental Patterning to Force Generation.

    PubMed

    Marston, Daniel J; Higgins, Christopher D; Peters, Kimberly A; Cupp, Timothy D; Dickinson, Daniel J; Pani, Ariel M; Moore, Regan P; Cox, Amanda H; Kiehart, Daniel P; Goldstein, Bob

    2016-08-22

    Apical constriction is a change in cell shape that drives key morphogenetic events including gastrulation and neural tube formation. Apical force-producing actomyosin networks drive apical constriction by contracting while connected to cell-cell junctions. The mechanisms by which developmental patterning regulates these actomyosin networks and associated junctions with spatial precision are not fully understood. Here we identify a myosin light-chain kinase MRCK-1 as a key regulator of C. elegans gastrulation that integrates spatial and developmental patterning information. We show that MRCK-1 is required for activation of contractile actomyosin dynamics and elevated cortical tension in the apical cell cortex of endoderm precursor cells. MRCK-1 is apically localized by active Cdc42 at the external, cell-cell contact-free surfaces of apically constricting cells, downstream of cell fate determination mechanisms. We establish that the junctional components α-catenin, β-catenin, and cadherin become highly enriched at the apical junctions of apically constricting cells and that MRCK-1 and myosin activity are required in vivo for this enrichment. Taken together, our results define mechanisms that position a myosin activator to a specific cell surface where it both locally increases cortical tension and locally enriches junctional components to facilitate apical constriction. These results reveal crucial links that can tie spatial information to local force generation to drive morphogenesis. PMID:27451898

  18. A lateral-axis micromachined tuning fork gyroscope with torsional Z-sensing and electrostatic force-balanced driving

    NASA Astrophysics Data System (ADS)

    Guo, Z. Y.; Yang, Z. C.; Zhao, Q. C.; Lin, L. T.; Ding, H. T.; Liu, X. S.; Cui, J.; Xie, H.; Yan, G. Z.

    2010-02-01

    A single-crystal silicon-based lateral-axis tuning-fork gyroscope (TFG) with electrostatic force-balanced (EFB) driving and torsional z-sensing is presented. The EFB comb drive used in this TFG can efficiently suppress the mechanical coupling in a simple manner. The TFG structure is also optimized to further reduce the coupling. Moreover, the Coriolis acceleration-induced out-of-plane rotation of the sensing mode is detected by using bending springs and differential comb fingers. This z-sensing design has relatively high Q, so this gyroscope can work at atmospheric pressure. This TFG design has been fabricated and tested. Measured in air, the device demonstrates a sensitivity of 2.9 mV/°/s, a full range of 800° s-1 with a 0.9% nonlinearity and the noise floor of 0.035°/s/Hz1/2. This TFG design also has very low coupling, where the measured drive-to-sense coupling and sense-to-drive coupling are -45 dB and -51 dB, respectively.

  19. Risky driving among UK regular armed forces personnel: changes over time

    PubMed Central

    Sheriff, Rebecca J Syed; Forbes, Harriet J; Wessely, Simon C; Greenberg, Neil; Jones, Norman; Fertout, Mohammed; Harrison, Kate; Fear, Nicola T

    2015-01-01

    Objectives To compare the prevalence of self-reported risky driving in a sample of UK military personnel at 2 different time points (2004 and 2009), and to identify the incidence of new onset risky driving and possible determinants of becoming a new risky driver. Methods Data were used from 2 phases of a military cohort study investigating the health and well-being of UK military personnel between 2004 and 2009. Participants were included if they were undertaking regular (rather than reserve) engagements, had completed both surveys and reported being a driver at both surveys. Univariable and multivariable logistic regression analyses were performed to examine the relationship between risky driving status and sociodemographic and military characteristics. Data analysis was conducted in 2011. Results The prevalence of risky driving reduced from 18% to 14%, over an average of 3.3 years. The incidence of new onset risky driving was 7%. Predictors for becoming a new risky driver were: younger age, not being in a relationship at phase 2 and harmful alcohol use. Those deployed after 2007 were less likely to become risky drivers following deployment, compared with those deployed before 2007 (adjusted OR 0.62 (95% CI 0.40 to 0.95)). Conclusions The prevalence of becoming a risky driver appears to have reduced over time. This paper suggests a number of explanations for this reduction, including changes in the way that the UK military have dealt with road safety with the introduction of the road safety campaign (in 2007). PMID:26399573

  20. Spatial driving forces of dominant land use/land cover transformations in the Dongjiang River watershed, Southern China.

    PubMed

    Gao, Changjun; Zhou, Ping; Jia, Peng; Liu, Zhiyong; Wei, Long; Tian, Huiling

    2016-02-01

    Information about changes in, and causes of, land use/land cover (LULC) is crucial for land use resource planning. We investigated the processes involved in LULC change (LUCC) in the Dongjiang Watershed, in Southern China, over a 15-year period to gain a better understanding of the causes of the main types of LUCC. Using a depth transition matrix and redundancy analysis (RDA), the major types and causes of LUCC for each LULC type over the past 15 years were identified. LUCC exhibited obvious net change, relatively low persistence, and high swap change. The swap changes in most LULC types were considered as a strong signal of LULC transformations. The driving forces behind swap changes were quantified and identified through RDA. The results showed that all driving forces played important roles in explaining swap changes of LULC, although the relative effects of these drivers varied widely with both LULC type and time period. Swap changes of the LULC types were generally classified into two categories. Some, e.g., built-up land and wetland, were affected mostly by landform and/or distance factors, while others, e.g., grassland and woodland, were modulated mostly by climate and/or socioeconomic factors. Selected spatial driving forces and local land use policies played important roles in explaining the dominant LUCC types, but on different timescales. These findings may improve understanding of the detailed processes involved in LUCC, landscape transformation, and the causes of LUCC in other areas with extensive LUCC and could help managers plan, design, and implement land resource management. PMID:26746657

  1. Pseudo-casimir structural force drives spinodal dewetting in nematic liquid crystals

    PubMed

    Ziherl; Podgornik; Zumer

    2000-02-01

    We analyze theoretically the fluctuation-induced force in thin nematic films subject to competing surface interactions, and we find that the force is attractive at small distances and repulsive otherwise. The results provide a consistent interpretation of a recent study of spinodal dewetting of 5CB on a silicon wafer [F. Vandenbrouck et al., Phys. Rev. Lett. 82, 2693 (1999)], implying that this experiment can be regarded as the first observation of the pseudo-Casimir effect in liquid crystals. PMID:11017485

  2. Transient-state fluctuationlike relation for the driving force on a biomolecule

    NASA Astrophysics Data System (ADS)

    Ponmurugan, M.; Vemparala, Satyavani

    2011-12-01

    In experiments and simulations the force acting on a single biomolecular system has been observed as a fluctuating quantity if the system is driven under constant velocity. We ask the question that is analogous to transient state entropy production and work fluctuation relations whether the force fluctuations observed in the single biomolecular system satisfy a transient state fluctuationlike relation, and the answer is in the affirmative. Using a constant velocity pulling steered molecular dynamics simulation study for protein unfolding, we confirm that the force fluctuations of this single biomolecular system satisfy a transient-state fluctuationlike relation (1)/(γ(T,v))ln[(Pv(+f))/(Pv(-f))]=f. Pv(±f) is the probability of positive and negative values of forces f=f⃗·n̂ for a given unfolding velocity of magnitude v and the pulling direction n⃗, n̂ is the unit vector of n⃗, and γ(T,v) is a factor that depends on initial equilibrium temperature T and the unfolding velocity. For different unfolding velocities we find that the system in the nonequilibrium pulling region displays substantial negative fluctuation in its unfolding force when velocity decreases. A negative value of force may indicate the emergence of refolding behavior during protein unfolding. We also find that γ(T,v)˜T-δvα and the system relaxation time τ(T,v)˜Tδv-(1+α), where α and δ are scaling exponents.

  3. Dynamic model of the force driving kinesin to move along microtubule-Simulation with a model system

    NASA Astrophysics Data System (ADS)

    Chou, Y. C.; Hsiao, Yi-Feng; To, Kiwing

    2015-09-01

    A dynamic model for the motility of kinesin, including stochastic-force generation and step formation is proposed. The force driving the motion of kinesin motor is generated by the impulse from the collision between the randomly moving long-chain stalk and the ratchet-shaped outer surface of microtubule. Most of the dynamical and statistical features of the motility of kinesin are reproduced in a simulation system, with (a) ratchet structures similar to the outer surface of microtubule, (b) a bead chain connected to two heads, similarly to the stalk of the real kinesin motor, and (c) the interaction between the heads of the simulated kinesin and microtubule. We also propose an experiment to discriminate between the conventional hand-over-hand model and the dynamic model.

  4. Binding dynamics and energetic insight into the molecular forces driving nucleotide binding by guanylate kinase.

    PubMed

    Kandeel, Mahmoud; Kitade, Yukio

    2011-01-01

    Plasmodium deoxyguanylate pathways are an attractive area of investigation for future metabolic and drug discovery studies due to their unique substrate specificities. We investigated the energetic contribution to guanylate kinase substrate binding and the forces underlying ligand recognition. In the range from 20 to 35°C, the thermodynamic profiles displayed marked decrease in binding enthalpy, while the free energy of binding showed little changes. GMP produced a large binding heat capacity change of -356 cal mol(-1) K(-1), indicating considerable conformational changes upon ligand binding. Interestingly, the calculated ΔCp was -32 cal mol(-1) K(-1), indicating that the accessible surface area is not the central change in substrate binding, and that other entropic forces, including conformational changes, are more predominant. The thermodynamic signature for GMP is inconsistent with rigid-body association, while dGMP showed more or less rigid-body association. These binding profiles explain the poor catalytic efficiency and low affinity for dGMP compared with GMP. At low temperature, the ligands bind to the receptor site under the effect of hydrophobic forces. Interestingly, by increasing the temperature, the entropic forces gradually vanish and proceed to a nonfavorable contribution, and the interaction occurs mainly through bonding, electrostatic forces, and van der Waals interactions. PMID:21360614

  5. ac propulsion system for an electric vehicle

    NASA Technical Reports Server (NTRS)

    Geppert, S.

    1980-01-01

    It is pointed out that dc drives will be the logical choice for current production electric vehicles (EV). However, by the mid-80's, there is a good chance that the price and reliability of suitable high-power semiconductors will allow for a competitive ac system. The driving force behind the ac approach is the induction motor, which has specific advantages relative to a dc shunt or series traction motor. These advantages would be an important factor in the case of a vehicle for which low maintenance characteristics are of primary importance. A description of an EV ac propulsion system is provided, taking into account the logic controller, the inverter, the motor, and a two-speed transmission-differential-axle assembly. The main barrier to the employment of the considered propulsion system in EV is not any technical problem, but inverter transistor cost.

  6. Earthworm invasion as the driving force behind plant invasion and community change in northeastern North American forests.

    PubMed

    Nuzzo, Victoria A; Maerz, John C; Blossey, Bernd

    2009-08-01

    Identification of factors that drive changes in plant community structure and contribute to decline and endangerment of native plant species is essential to the development of appropriate management strategies. Introduced species are assumed to be driving causes of shifts in native plant communities, but unequivocal evidence supporting this view is frequently lacking. We measured native vegetation, non-native earthworm biomass, and leaf-litter volume in 15 forests in the presence and absence of 3 non-native plant species (Microstegium vimineum, Alliaria petiolata, Berberis thunbergii) to assess the general impact of non-native plant and earthworm invasions on native plant communities in northeastern United States. Non-native plant cover was positively correlated with total native plant cover and non-native earthworm biomass. Earthworm biomass was negatively associated with cover of native woody and most herbaceous plants and with litter volume. Graminoid cover was positively associated with non-native earthworm biomass and non-native plant cover. These earthworm-associated responses were detected at all sites despite differences in earthworm species and abundance, composition of the native plant community, identity of invasive plant species, and geographic region. These patterns suggest earthworm invasion, rather than non-native plant invasion, is the driving force behind changes in forest plant communities in northeastern North America, including declines in native plant species, and earthworm invasions appear to facilitate plant invasions in these forests. Thus, a focus on management of invasive plant species may be insufficient to protect northeastern forest understory species. PMID:19236448

  7. Vegetation coverage change and associated driving forces in mountain areas of Northwestern Yunnan, China using RS and GIS.

    PubMed

    Peng, Jian; Liu, Yinghui; Shen, Hong; Han, Yinan; Pan, Yajing

    2012-08-01

    The dynamics of vegetation coverage and associated driving forces are one of the key issues in global environmental change. In the study, taking Lijiang County as a case, the Normalized Difference Vegetation Index was used to quantify vegetation coverage change in mountain areas of Northwestern Yunnan, China, with the application of remote sensing data and GIS technologies. And associated driving forces of vegetation coverage change were also analyzed, with a focus on land use change and elevation. The results showed that there was high vegetation coverage with a significant increase in the whole county during 1986-2002. However, due to economic development and the implementation of environmental protection polices, vegetation coverage change in the county showed distinct spatial diversity, which mainly behaved as the increasing in the northwest of the county with low human activities, and the decreasing in the south with high economic development. The results also showed that as a restrictive factor, elevation was of great signification on the spatial distribution of vegetation coverage in a broad scale; while in the county level, it was land use that determined the vegetation coverage, since the change of vegetation coverage grades in the study area was mainly associated with the change of land use types. PMID:21912871

  8. Driving forces and the influence of the buffer composition on the complexation reaction between ibuprofen and HPCD.

    PubMed

    Perlovich, German L; Skar, Merete; Bauer-Brandl, Annette

    2003-10-01

    Cyclodextrins are often used in order to increase the aqueous solubility of drug substances by complexation. In order to investigate the complexation reaction of ibuprofen and hydroxypropyl-beta-cyclodextrin, titration calorimetry was used as a direct method. The thermodynamic parameters of the complexation process (stability constant, K(11); complexation enthalpy, deltaH(c) degrees ) were obtained in two different buffer systems (citric acid/sodium-phosphate and phosphoric acid) at various pH values. Based on these data the relative contributions of the enthalpic and entropic terms of the Gibbs energy to the complexation process have been analyzed. In both buffers the enthalpic and entropic terms are of different sign and this case corresponds to a 'nonclassical' model of hydrophobic interaction. In citric buffer, the main driving force of complexation is the entropy, which increases from 60 to 67% while the pH of the solution increases from 3.2 to 8.0. However, for the phosphoric buffer the entropic term decreases from 60 to 45%, while the pH-value of the solution increases from 5.0 to 8.2, and the driving force of the complexation process changes from entropy to enthalpy. The experimental data of the present study are compared to results of other authors and discrepancies discussed in detail. PMID:14550885

  9. Relative importance of driving force and electrostatic interactions in the reduction of multihaem cytochromes by small molecules.

    PubMed

    Quintas, Pedro O; Cepeda, Andreia P; Borges, Nuno; Catarino, Teresa; Turner, David L

    2013-06-01

    Multihaem cytochromes are essential to the energetics of organisms capable of bioremediation and energy production. The haems in several of these cytochromes have been discriminated thermodynamically and their individual rates of reduction by small electron donors were characterized. The kinetic characterization of individual haems used the Marcus theory of electron transfer and assumed that the rates of reduction of each haem by sodium dithionite depend only on the driving force, while electrostatic interactions were neglected. To determine the relative importance of these factors in controlling the rates, we studied the effect of ionic strength on the redox potential and the rate of reduction by dithionite of native Methylophilus methylotrophus cytochrome c″ and three mutants at different pH values. We found that the main factor determining the rate is the driving force and that Marcus theory describes this satisfactorily. This validates the method of the simultaneous fitting of kinetic and thermodynamic data in multihaem cytochromes and opens the way for further investigation into the mechanisms of these proteins. PMID:23428398

  10. Land use changes and its driving forces in hilly ecological restoration area based on gis and rs of northern china

    PubMed Central

    Gao, Peng; Niu, Xiang; Wang, Bing; Zheng, Yunlong

    2015-01-01

    Land use change is one of the important aspects of the regional ecological restoration research. With remote sensing (RS) image in 2003, 2007 and 2012, using geographic information system (GIS) technologies, the land use pattern changes in Yimeng Mountain ecological restoration area in China and its driving force factors were studied. Results showed that: (1) Cultivated land constituted the largest area during 10 years, and followed by forest land and grass land; cultivated land and unused land were reduced by 28.43% and 44.32%, whereas forest land, water area and land for water facilities and others were increased. (2) During 2003–2007, forest land change showed the largest, followed by unused land and grass land; however, during 2008–2012, water area and land for water facilities change showed the largest, followed by grass land and unused land. (3) Land use degree was above the average level, it was in the developing period during 2003–2007 and in the degenerating period during 2008–2012. (4) Ecological Restoration Projects can greatly change the micro topography, increase vegetation coverage, and then induce significant changes in the land use distribution, which were the main driving force factors of the land use pattern change in the ecological restoration area. PMID:26047160

  11. Thermodynamic Driving Force of the γ → ɛ Transformation and Resulting MS Temperature in High-Mn Steels

    NASA Astrophysics Data System (ADS)

    Pisarik, S. T.; Van Aken, D. C.

    2016-03-01

    Two-stage transformation-induced plasticity (TRIP) behavior characterized by the martensitic transformations, γ → ɛ → α', has produced exceptional tensile strengths and work hardening rates in Fe-14 wt pct Mn alloys containing Al and Si. A regular solution model has been developed to accurately calculate Δ G γ → ɛ for a given TRIP alloy and the calculated driving force is used to determine the M S ɛ temperature. The regular solution model developed here predicted driving forces that corresponded well with reported microstructures and behavior of seven FeMnAlSiC steels from literature when considered in conjunction with nucleating defect critical size and material process history. The role of available nucleating defects of critical size, n*, has been linked to the stacking fault energy necessary to observe the γ → ɛ transformation and the M S ɛ temperature. The regular solution model provided excellent correlation between calculated M S ɛ temperatures and those measured experimentally in 89 alloys from literature and suggested n* = 4 is the critical size of a nucleating defect in annealed microstructures. Factors affecting the γ → ɛ transformation and the M S ɛ temperature have been identified as prior austenite grain size, dislocation substructure due to prior deformation, and solute segregation.

  12. Commentary: Forces That Drive the Vape Shop Industry and Implications for the Health Professions

    PubMed Central

    Sussman, Steve; Baezconde-Garbanati, Lourdes; Garcia, Robert; Barker, Dianne C.; Samet, Jonathan M.; Leventhal, Adam; Unger, Jennifer B.

    2016-01-01

    At least three factors may be driving the evolution of the vape shop industry, a rapidly growing market sector that specializes in the sales of electronic cigarettes: (1) the tobacco industry, (2) the public health sector and its diverse stakeholders, and (3) consumer demand. These influences and the responses of the vape shop sector have resulted in a rapidly changing landscape. This commentary briefly discusses these three factors and the implications for the health professions, as they address the vape shop industry and its consequences for public health. PMID:25967071

  13. Commentary: Forces That Drive the Vape Shop Industry and Implications for the Health Professions.

    PubMed

    Sussman, Steve; Baezconde-Garbanati, Lourdes; Garcia, Robert; Barker, Dianne C; Samet, Jonathan M; Leventhal, Adam; Unger, Jennifer B

    2016-09-01

    At least three factors may be driving the evolution of the vape shop industry, a rapidly growing market sector that specializes in the sales of electronic cigarettes: (1) the tobacco industry, (2) the public health sector and its diverse stakeholders, and (3) consumer demand. These influences and the responses of the vape shop sector have resulted in a rapidly changing landscape. This commentary briefly discusses these three factors and the implications for the health professions, as they address the vape shop industry and its consequences for public health. PMID:25967071

  14. Forest dynamics and its driving forces of sub-tropical forest in South China

    PubMed Central

    Ma, Lei; Lian, Juyu; Lin, Guojun; Cao, Honglin; Huang, Zhongliang; Guan, Dongsheng

    2016-01-01

    Tree mortality and recruitment are key factors influencing forest dynamics, but the driving mechanisms of these processes remain unclear. To better understand these driving mechanisms, we studied forest dynamics over a 5-year period in a 20-ha sub-tropical forest in the Dinghushan Nature Reserve, South China. The goal was to identify determinants of tree mortality/recruitment at the local scale using neighborhood analyses on some locally dominant tree species. Results show that the study plot was more dynamic than some temperate and tropical forests in a comparison to large, long-term forest dynamics plots. Over the 5-year period, mortality rates ranged from 1.67 to 12.33% per year while recruitment rates ranged from 0 to 20.26% per year. Tree size had the most consistent effect on mortality across species. Recruitment into the ≥1-cm size class consistently occurred where local con-specific density was high. This suggests that recruitment may be limited by seed dispersal. Hetero-specific individuals also influenced recruitment significantly for some species. Canopy species had low recruitment into the ≥1-cm size class over the 5-year period. In conclusion, tree mortality and recruitment for sixteen species in this plot was likely limited by seed dispersal and density-dependence. PMID:26940005

  15. Causality of global warming seen from observations: a scale analysis of driving force of the surface air temperature time series in the Northern Hemisphere

    NASA Astrophysics Data System (ADS)

    Yang, Peicai; Wang, Geli; Zhang, Feng; Zhou, Xiuji

    2016-05-01

    By using the slow feature analysis, we reconstructed the driving force for an observed monthly surface air temperature anomaly time series in the northern hemisphere. Wavelet transformation technique was then used to analyze the scale structure of the derived driving force and its causal relationship with global warming. Results showed that the driving force for the analyzed temperature climate system included two independent degrees of freedom which respectively represented the effects of 22-year solar cycle and Atlantic Multidecadal Oscillation on the climate. More importantly, the driving force is modulated in amplitude by signals with much longer time periods. The modulation controls the energy input to the climate system and its effect on the global warming is decisive. In addition, through analyzing phase transitions from zero to extremes of the modulating signals, we provide a projection for the future trend of the surface air temperature. In specific, in the next 45-65 years, the driving force will continue to rise which will drive the air temperature even warmer. This is a long term natural trend determined by the modulating amplitude signals, but not directly related to human activity.

  16. Self-similar expansion of solar coronal mass ejections: Implications for Lorentz self-force driving

    SciTech Connect

    Subramanian, Prasad; Arunbabu, K. P.; Mauriya, Adwiteey; Vourlidas, Angelos

    2014-08-01

    We examine the propagation of several coronal mass ejections (CMEs) with well-observed flux rope signatures in the field of view of the SECCHI coronagraphs on board the STEREO satellites using the graduated cylindrical shell fitting method of Thernisien et al. We find that the manner in which they propagate is approximately self-similar; i.e., the ratio (κ) of the flux rope minor radius to its major radius remains approximately constant with time. We use this observation of self-similarity to draw conclusions regarding the local pitch angle (γ) of the flux rope magnetic field and the misalignment angle (χ) between the current density J and the magnetic field B. Our results suggest that the magnetic field and current configurations inside flux ropes deviate substantially from a force-free state in typical coronagraph fields of view, validating the idea of CMEs being driven by Lorentz self-forces.

  17. Self-similar Expansion of Solar Coronal Mass Ejections: Implications for Lorentz Self-force Driving

    NASA Astrophysics Data System (ADS)

    Subramanian, Prasad; Arunbabu, K. P.; Vourlidas, Angelos; Mauriya, Adwiteey

    2014-08-01

    We examine the propagation of several coronal mass ejections (CMEs) with well-observed flux rope signatures in the field of view of the SECCHI coronagraphs on board the STEREO satellites using the graduated cylindrical shell fitting method of Thernisien et al. We find that the manner in which they propagate is approximately self-similar; i.e., the ratio (κ) of the flux rope minor radius to its major radius remains approximately constant with time. We use this observation of self-similarity to draw conclusions regarding the local pitch angle (γ) of the flux rope magnetic field and the misalignment angle (χ) between the current density J and the magnetic field B. Our results suggest that the magnetic field and current configurations inside flux ropes deviate substantially from a force-free state in typical coronagraph fields of view, validating the idea of CMEs being driven by Lorentz self-forces.

  18. Dominant Driving Force for Protein Folding -- A Result from Analyzing the Statistical Potential

    NASA Astrophysics Data System (ADS)

    Li, Hao; Tang, Chao; Wingreen, Ned

    1997-03-01

    In a statistical approach, the energy of a particular substructure in proteins is related to its number of appearance in the protein structure data bank via a Boltzmann factor. Such knowledge based potentials are widely used in protein structure prediction. A well known example is the inter-residue contact energies between different types of amino acids -- a 20× 20 matrix derived by Miyazawa and Jernigan (MJ). We have analyzed the MJ matrix using the method of eigenvalue decomposition. We find that the MJ matrix can be accurately reconstructed by using only the two largest eigenvalues and the corresponding eigenvectors. The matrix elements can be simply expressed as M_ij=C_0+C_1(q_i+q_j)+C_2q_iq_j, with C's constants, and 20 q values associated with 20 amino acids. We find that this regularity is due to hydrophobic force and a force of demixing, the latter obeying Hildebrand's solubility theory for simple liquids.

  19. Both contractile axial and lateral traction force dynamics drive amoeboid cell motility

    PubMed Central

    Bastounis, Effie; Meili, Ruedi; Álvarez-González, Begoña; Francois, Joshua; del Álamo, Juan C.; Lasheras, Juan C.

    2014-01-01

    Chemotaxing Dictyostelium discoideum cells adapt their morphology and migration speed in response to intrinsic and extrinsic cues. Using Fourier traction force microscopy, we measured the spatiotemporal evolution of shape and traction stresses and constructed traction tension kymographs to analyze cell motility as a function of the dynamics of the cell’s mechanically active traction adhesions. We show that wild-type cells migrate in a step-wise fashion, mainly forming stationary traction adhesions along their anterior–posterior axes and exerting strong contractile axial forces. We demonstrate that lateral forces are also important for motility, especially for migration on highly adhesive substrates. Analysis of two mutant strains lacking distinct actin cross-linkers (mhcA− and abp120− cells) on normal and highly adhesive substrates supports a key role for lateral contractions in amoeboid cell motility, whereas the differences in their traction adhesion dynamics suggest that these two strains use distinct mechanisms to achieve migration. Finally, we provide evidence that the above patterns of migration may be conserved in mammalian amoeboid cells. PMID:24637328

  20. Single molecule compression reveals intra-protein forces drive cytotoxin pore formation

    PubMed Central

    Czajkowsky, Daniel M; Sun, Jielin; Shen, Yi; Shao, Zhifeng

    2015-01-01

    Perfringolysin O (PFO) is a prototypical member of a large family of pore-forming proteins that undergo a significant reduction in height during the transition from the membrane-assembled prepore to the membrane-inserted pore. Here, we show that targeted application of compressive forces can catalyze this conformational change in individual PFO complexes trapped at the prepore stage, recapitulating this critical step of the spontaneous process. The free energy landscape determined from these measurements is in good agreement with that obtained from molecular dynamics simulations showing that an equivalent internal force is generated by the interaction of the exposed hydrophobic residues with the membrane. This hydrophobic force is transmitted across the entire structure to produce a compressive stress across a distant, otherwise stable domain, catalyzing its transition from an extended to compact conformation. Single molecule compression is likely to become an important tool to investigate conformational transitions in membrane proteins. DOI: http://dx.doi.org/10.7554/eLife.08421.001 PMID:26652734

  1. Pressure perturbations from geologic carbon sequestration: Area-of-review boundaries and borehole leakage driving forces

    SciTech Connect

    Nicot, J.-P.; Oldenburg, C.M.; Bryant, S.L.; Hovorka, S.D.

    2009-07-01

    We investigate the possibility that brine could be displaced upward into potable water through wells. Because of the large volumes of CO2 to be injected, the influence of the zone of elevated pressure on potential conduits such as well boreholes could extend many kilometers from the injection site-farther than the CO2 plume itself. The traditional approach to address potential brine leakage related to fluid injection is to set an area of fixed radius around the injection well/zone and to examine wells and other potentially open pathways located in the ''Area-of-Review'' (AoR). This suggests that the AoR eeds to be defined in terms of the potential for a given pressure perturbation to drive upward fluid flow in any given system rather than on some arbitrary pressure rise. We present an analysis that focuses on the changes in density/salinity of the fluids in the potentially leaking wellbore.

  2. Line tension at lipid phase boundaries as driving force for HIV fusion peptide-mediated fusion

    NASA Astrophysics Data System (ADS)

    Yang, Sung-Tae; Kiessling, Volker; Tamm, Lukas K.

    2016-04-01

    Lipids and proteins are organized in cellular membranes in clusters, often called `lipid rafts'. Although raft-constituent ordered lipid domains are thought to be energetically unfavourable for membrane fusion, rafts have long been implicated in many biological fusion processes. For the case of HIV gp41-mediated membrane fusion, this apparent contradiction can be resolved by recognizing that the interfaces between ordered and disordered lipid domains are the predominant sites of fusion. Here we show that line tension at lipid domain boundaries contributes significant energy to drive gp41-fusion peptide-mediated fusion. This energy, which depends on the hydrophobic mismatch between ordered and disordered lipid domains, may contribute tens of kBT to fusion, that is, it is comparable to the energy required to form a lipid stalk intermediate. Line-active compounds such as vitamin E lower line tension in inhomogeneous membranes, thereby inhibit membrane fusion, and thus may be useful natural viral entry inhibitors.

  3. What drives interannual variability of hypoxia in Chesapeake Bay: Climate forcing versus nutrient loading?

    NASA Astrophysics Data System (ADS)

    Li, Ming; Lee, Younjoo J.; Testa, Jeremy M.; Li, Yun; Ni, Wenfei; Kemp, W. Michael; Di Toro, Dominic M.

    2016-03-01

    Oxygen depletion in estuaries is a worldwide problem with detrimental effects on many organisms. Although nutrient loading has been stabilized for a number of these systems, seasonal hypoxia persists and displays large year-to-year variations, with larger hypoxic volumes in wetter years and smaller hypoxic volumes in drier years. Data analysis points to climate as a driver of interannual hypoxia variability, but nutrient inputs covary with freshwater flow. Here we report an oxygen budget analysis of Chesapeake Bay to quantify relative contributions of physical and biogeochemical processes. Vertical diffusive flux declines with river discharge, whereas longitudinal advective flux increases with river discharge, such that their total supply of oxygen to bottom water is relatively unchanged. However, water column respiration exhibits large interannual fluctuations and is correlated with primary production and hypoxic volume. Hence, the model results suggest that nutrient loading is the main mechanism driving interannual hypoxia variability in Chesapeake Bay.

  4. Line tension at lipid phase boundaries as driving force for HIV fusion peptide-mediated fusion.

    PubMed

    Yang, Sung-Tae; Kiessling, Volker; Tamm, Lukas K

    2016-01-01

    Lipids and proteins are organized in cellular membranes in clusters, often called 'lipid rafts'. Although raft-constituent ordered lipid domains are thought to be energetically unfavourable for membrane fusion, rafts have long been implicated in many biological fusion processes. For the case of HIV gp41-mediated membrane fusion, this apparent contradiction can be resolved by recognizing that the interfaces between ordered and disordered lipid domains are the predominant sites of fusion. Here we show that line tension at lipid domain boundaries contributes significant energy to drive gp41-fusion peptide-mediated fusion. This energy, which depends on the hydrophobic mismatch between ordered and disordered lipid domains, may contribute tens of kBT to fusion, that is, it is comparable to the energy required to form a lipid stalk intermediate. Line-active compounds such as vitamin E lower line tension in inhomogeneous membranes, thereby inhibit membrane fusion, and thus may be useful natural viral entry inhibitors. PMID:27113279

  5. Direction detectable static magnetic field imaging by frequency-modulated magnetic force microscopy with an AC magnetic field driven soft magnetic tip

    NASA Astrophysics Data System (ADS)

    Saito, Hitoshi; Ito, Ryoichi; Egawa, Genta; Li, Zhenghua; Yoshimura, Satoru

    2011-04-01

    Direction detectable static magnetic field imaging, which directly distinguishes the up and down direction of static perpendicular magnetic field from a sample surface and the polarity of magnetic charges on the surface, was demonstrated for CoCrPt-SiO2 perpendicular magnetic recording media based on a frequency-modulated magnetic force microscopy (FM-MFM), which uses a frequency modulation of the cantilever oscillation induced by an alternating force from the tip-sample magnetic interaction. In this study, to generate the alternating force, we used a NiFe soft magnetic tip driven by the ac magnetic field of a soft ferrite core and imaged the direction and the amplitude of the static magnetic field from the recorded bits. This method enables measurement of the static magnetic field near a sample surface, which is masked by short range forces of the surface. The present method will be effective in analyzing the microscopic magnetic domain structure of hard magnetic samples.

  6. Stability enhancement and fuel economy of the 4-wheel-drive hybrid electric vehicles by optimal tyre force distribution

    NASA Astrophysics Data System (ADS)

    Goodarzi, Avesta; Mohammadi, Masoud

    2014-04-01

    In this paper, vehicle stability control and fuel economy for a 4-wheel-drive hybrid vehicle are investigated. The integrated controller is designed within three layers. The first layer determines the total yaw moment and total lateral force made by using an optimal controller method to follow the desired dynamic behaviour of a vehicle. The second layer determines optimum tyre force distribution in order to optimise tyre usage and find out how the tyres should share longitudinal and lateral forces to achieve a target vehicle response under the assumption that all four wheels can be independently steered, driven, and braked. In the third layer, the active steering, wheel slip, and electrical motor torque controllers are designed. In the front axle, internal combustion engine (ICE) is coupled to an electric motor (EM). The control strategy has to determine the power distribution between ICE and EM to minimise fuel consumption and allowing the vehicle to be charge sustaining. Finally, simulations performed in MATLAB/SIMULINK environment show that the proposed structure could enhance the vehicle stability and fuel economy in different manoeuvres.

  7. Complete canthi removal reveals that forces from the amnioserosa alone are sufficient to drive dorsal closure in Drosophila

    PubMed Central

    Wells, Adrienne R.; Zou, Roger S.; Tulu, U. Serdar; Sokolow, Adam C.; Crawford, Janice M.; Edwards, Glenn S.; Kiehart, Daniel P.

    2014-01-01

    Drosophila's dorsal closure provides an excellent model system with which to analyze biomechanical processes during morphogenesis. During native closure, the amnioserosa, flanked by two lateral epidermal sheets, forms an eye-shaped opening with canthi at each corner. The dynamics of amnioserosa cells and actomyosin purse strings in the leading edges of epidermal cells promote closure, whereas the bulk of the lateral epidermis opposes closure. Canthi maintain purse string curvature (necessary for their dorsalward forces), and zipping at the canthi shortens leading edges, ensuring a continuous epithelium at closure completion. We investigated the requirement for intact canthi during closure with laser dissection approaches. Dissection of one or both canthi resulted in tissue recoil and flattening of each purse string. After recoil and a temporary pause, closure resumed at approximately native rates until slowing near the completion of closure. Thus the amnioserosa alone can drive closure after dissection of one or both canthi, requiring neither substantial purse string curvature nor zipping during the bulk of closure. How the embryo coordinates multiple, large forces (each of which is orders of magnitude greater than the net force) during native closure and is also resilient to multiple perturbations are key extant questions. PMID:25253724

  8. Specific sine-Gordon soliton dynamics in the presence of external driving forces

    NASA Astrophysics Data System (ADS)

    Reinisch, Gilbert; Fernandez, Jean Claude

    1981-07-01

    We consider the acceleration of a single sine-Gordon (SG) soliton kink wave by an external time-dependent force χ(t), first without any dissipation, and then in the presence of a weak damping effect. We use the method of Fogel, Trullinger, Bishop, and Krumhansl [FTBK,

    Phys. Rev. B 45, 1578 (1977)]
    which consists in perturbing the SG equation about its kink solution and solving the resulting linear inhomogeneous equation for the perturbation function by expanding it in the complete set of eigenfunctions of the Schrödinger operator with potential 1-2 2x. Our results concerning the accelerated soliton dynamics strongly disagree with the FTBK conclusion that the soliton should undergo an acceleration proportional to χ (this is the so-called Newtonian dynamical behavior of SG soliton, which is also predicted by all existing perturbation theories dealing with the perturbed SG equation). On the contrary, we find that this Newtonian acceleration is exactly balanced by a reaction effect of the continuous phonon spectrum excited by the external force χ, upon the moving kink, so that there is no soliton acceleration at all within the frame of this linear perturbation theory, i.e., for small time values. Actually, we show by the simple example of a static external force that the acceleration of an initially static kink is a higher-order effect (proportional to χt2, where t is the time, instead of being constant and proportional to χ). We emphasize that this last result has already been checked by numerical experiments and show, both by theory and by numerical simulations, that it does not qualitatively change when a small damping effect is taken into account.

  9. Chronic Inflammation-Related HPV: A Driving Force Speeds Oropharyngeal Carcinogenesis

    PubMed Central

    Liu, Xin; Ma, Xiangrui; Lei, Zhengge; Feng, Hao; Wang, Shasha; Cen, Xiao; Gao, Shiyu; Jiang, Yaping; Jiang, Jian; Chen, Qianming; Tang, Yajie; Tang, Yaling; Liang, Xinhua

    2015-01-01

    Oropharyngeal squamous cell carcinoma (OPSCC) has been known to be a highly aggressive disease associated with human papilloma virus (HPV) infection. To investigate the relationship between HPV and chronic inflammation in oropharyngeal carcinogenesis, we collected 140 oral mucous fresh specimens including 50 OPSCC patients, 50 cancer in situ, 30 precancerous lesions, and 10 normal oral mucous. Our data demonstrated that there was a significantly higher proportion of severe chronic inflammation in dysplastic epithelia in comparison with that in normal tissues (P<0.001). The positive rate of HPV 16 was parallel with the chronic inflammation degrees from mild to severe inflammation (P<0.05). The positive rate of HPV 16 was progressively improved with the malignant progression of oral mucous (P<0.05). In addition, CD11b+ LIN- HLA-DR-CD33+ MDSCs were a critical cell population that mediates inflammation response and immune suppression in HPV-positive OPSCC. These indicated that persistent chronic inflammation-related HPV infection might drive oropharyngeal carcinogenesis and MDSCs might pay an important role during this process. Thus, a combination of HPV infection and inflammation expression might become a helpful biomedical marker to predict oropharyngeal carcinogenesis. PMID:26193368

  10. Inherent Driving Force for Charge Separation in Curved Stacks of Oligothiophenes

    SciTech Connect

    Wu, Qin

    2015-01-30

    Coexistence of high local charge mobility and an energy gradient can lead to efficient free charge carrier generation from geminate charge transfer states at the donor–acceptor interface in bulk heterojunction organic photovoltaics. It is, however, not clear what polymer microstructures can support such coexistence. Using recent methods from density functional theory, we propose that a stack of similarly curved oligothiophene chains can deliver the requirements for efficient charge separation. Curved stacks are stable because of the polymer’s strong π-stacking ability and because backbone torsions are flexible in neutral chains. However, energy of a charge in a polymer chain has remarkably stronger dependence on torsions. The trend of increasing planarity in curved stacks effectively creates an energy gradient that drives charge in one direction. The curvature of these partially ordered stacks is found to beneficially interact with fullerenes for charge separation. The curved stacks, therefore, are identified as possible building blocks for interfacial structures that lead to efficient free carrier generation in high-performing organic photovoltaic systems.

  11. Driving force for crystallization of anionic lipid membranes revealed by atomistic simulations.

    PubMed

    Qiao, Bao Fu; Olvera de la Cruz, Monica

    2013-05-01

    Crystalline vesicles are promising nanomaterials due to their mechanical stability in various environments. To control their fabrication, it is essential to understand the effects of different experimental conditions on crystallization. Here we perform atomistic molecular dynamics simulations of anionic lipid membranes of 1,2-dilauroyl-sn-glycero-3-phosphol-L-serine. In the presence of Na(+) monovalent counterions, we access the phase transition from the liquid-like disordered liquid-crystalline phase to the ordered gel phase by lowering the temperature of the system. The phase transition is conclusively evidenced by the scattering structure factor. Quantitative calculations show that the enhancement of the intertail van der Waals interaction (about -6 k(B)T) plays a dominant role in driving the phase transition rather than the increase in the cohesive interaction (-0.5 k(B)T) between lipids and counterions. Meanwhile, in the presence of multivalent counterions of Zn(2+) or La(3+) the gel phase is found throughout the temperature range investigated. Moreover, the van der Waals interaction per hydrocarbon group is ∼20% stronger in the gel phase (∼ -1.8 k(B)T regardless of the counterions) than in the liquid-crystalline phase (-1.5 k(B)T). PMID:23565965

  12. Inherent Driving Force for Charge Separation in Curved Stacks of Oligothiophenes

    DOE PAGESBeta

    Wu, Qin

    2015-01-30

    Coexistence of high local charge mobility and an energy gradient can lead to efficient free charge carrier generation from geminate charge transfer states at the donor–acceptor interface in bulk heterojunction organic photovoltaics. It is, however, not clear what polymer microstructures can support such coexistence. Using recent methods from density functional theory, we propose that a stack of similarly curved oligothiophene chains can deliver the requirements for efficient charge separation. Curved stacks are stable because of the polymer’s strong π-stacking ability and because backbone torsions are flexible in neutral chains. However, energy of a charge in a polymer chain has remarkablymore » stronger dependence on torsions. The trend of increasing planarity in curved stacks effectively creates an energy gradient that drives charge in one direction. The curvature of these partially ordered stacks is found to beneficially interact with fullerenes for charge separation. The curved stacks, therefore, are identified as possible building blocks for interfacial structures that lead to efficient free carrier generation in high-performing organic photovoltaic systems.« less

  13. Line tension at lipid phase boundaries as driving force for HIV fusion peptide-mediated fusion

    PubMed Central

    Yang, Sung-Tae; Kiessling, Volker; Tamm, Lukas K.

    2016-01-01

    Lipids and proteins are organized in cellular membranes in clusters, often called ‘lipid rafts'. Although raft-constituent ordered lipid domains are thought to be energetically unfavourable for membrane fusion, rafts have long been implicated in many biological fusion processes. For the case of HIV gp41-mediated membrane fusion, this apparent contradiction can be resolved by recognizing that the interfaces between ordered and disordered lipid domains are the predominant sites of fusion. Here we show that line tension at lipid domain boundaries contributes significant energy to drive gp41-fusion peptide-mediated fusion. This energy, which depends on the hydrophobic mismatch between ordered and disordered lipid domains, may contribute tens of kBT to fusion, that is, it is comparable to the energy required to form a lipid stalk intermediate. Line-active compounds such as vitamin E lower line tension in inhomogeneous membranes, thereby inhibit membrane fusion, and thus may be useful natural viral entry inhibitors. PMID:27113279

  14. Predation risk as a driving force for sexual segregation: a cross-population comparison.

    PubMed

    Croft, Darren P; Morrell, Lesley J; Wade, Amy S; Piyapong, Chantima; Ioannou, Christos C; Dyer, John R G; Chapman, Ben B; Wong, Yan; Krause, Jens

    2006-06-01

    Sexual segregation is widespread throughout the animal kingdom. Although a number of hypotheses have been proposed to account for observed patterns, the generality of the mechanisms remains debated. One possible reason for this is the focus on segregation patterns in large mammals such as ungulates, where the majority of studies are descriptions of a single population. Here, we present the results of a cross‐population comparison of patterns of sexual segregation in the Trinidadian guppy, Poecilia reticulata. We relate observed patterns to experimental quantification of predation risk and sexual harassment of females by males in eight populations. We find that the degree of segregation increases with predation risk, with deeper waters becoming increasingly female biased. Furthermore, we observed that levels of male harassment are lower in deeper water but only in those rivers that contain major guppy predators. We conclude that sexual segregation in guppies is consistent with the predation risk hypothesis: sexual segregation results from a combination of predation risk driving males (the more vulnerable sex) into less risky habitats and females gaining benefits of reduced sexual harassment by remaining in high‐predation environments. PMID:16649156

  15. Thermodynamic Driving Forces for Dye Molecule Position and Orientation in Nanoconfined Solvents.

    PubMed

    Harvey, Jacob A; Thompson, Ward H

    2015-07-23

    The results of replica exchange molecular dynamics simulations of a coumarin 153 (C153) dye molecule dissolved in ethanol confined within a 2.4 nm hydrophilic amorphous silica pore are presented. The C153 dye position and orientation distributions provide insight into time-dependent fluorescence measurements in nanoconfined solvents as well as general features of chemistry in mesoporous materials. In addition to the distributions themselves, the free energy, internal energy, and entropic contributions have been calculated to explore the factors determining the distributions. The most likely location of C153 is found to be near the pore surface, but two possible hydrogen-bonding structures lead to differing orientations. Internal energy and entropy are found to be competing forces within the pore, with entropy playing a significant role with unexpected consequences. These results represent a crucial step in determining how the nanoconfining framework can affect measurements of solvation dynamics. PMID:25295835

  16. Driving force dependence of charge separation and recombination processes in dyads of nucleotides and strongly electron-donating oligothiophenes.

    PubMed

    Lin, Shih-Hsun; Fujitsuka, Mamoru; Ishikawa, Mayuka; Majima, Tetsuro

    2014-10-23

    Charge transfer in DNA has attracted great attention of scientists because of its importance in biological processes. However, our knowledge on excess-electron transfer in DNA still remains limited in comparison to numerous studies of hole transfer in DNA. To clarify the dynamics of excess-electron transfer in DNA by photochemical techniques, new electron-donating photosensitizers should be developed. Herein, a terthiophene and two 3,4-ethylenedioxythiophene oligomers were used as photosensitizers in dyads including natural nucleobases as electron acceptors. The charge separation and recombination processes in the dyads were investigated by femtosecond laser flash photolysis, and the driving force dependence of these rate constants was discussed on the basis of the Marcus theory. From this study, the conformation effect on charge recombination process was found. We expect that 3,4-ethylenedioxythiophene oligomers are useful in investigation of excess-electron-transfer dynamics in DNA. PMID:25265410

  17. Research Problems Associated with Limiting the Applied Force in Vibration Tests and Conducting Base-Drive Modal Vibration Tests

    NASA Technical Reports Server (NTRS)

    Scharton, Terry D.

    1995-01-01

    The intent of this paper is to make a case for developing and conducting vibration tests which are both realistic and practical (a question of tailoring versus standards). Tests are essential for finding things overlooked in the analyses. The best test is often the most realistic test which can be conducted within the cost and budget constraints. Some standards are essential, but the author believes more in the individual's ingenuity to solve a specific problem than in the application of standards which reduce problems (and technology) to their lowest common denominator. Force limited vibration tests and base-drive modal tests are two examples of realistic, but practical testing approaches. Since both of these approaches are relatively new, a number of interesting research problems exist, and these are emphasized herein.

  18. RUNX2 and the PI3K/AKT axis reciprocal activation as a driving force for tumor progression.

    PubMed

    Cohen-Solal, Karine A; Boregowda, Rajeev K; Lasfar, Ahmed

    2015-01-01

    From the first reported role of the transcription factor RUNX2 in osteoblast and chondrocyte differentiation and migration to its involvement in promigratory/proinvasive behavior of breast, prostate, and thyroid cancer cells, osteosarcoma, or melanoma cells, RUNX2 currently emerges as a key player in metastasis. In this review, we address the interaction of RUNX2 with the PI3K/AKT signaling pathway, one of the critical axes controlling cancer growth and metastasis. AKT, either by directly phosphorylating/activating RUNX2 or phosphorylating/inactivating regulators of RUNX2 stability or activity, contributes to RUNX2 transcriptional activity. Reciprocally, the activation of the PI3K/AKT pathway by RUNX2 regulation of its different components has been described in non-transformed and transformed cells. This mutual activation in the context of cancer cells exhibiting constitutive AKT activation and high levels of RUNX2 might constitute a major driving force in tumor progression and aggressiveness. PMID:26204939

  19. Energetic driving force for preferential binding of self-interstitial atoms to Fe grain boundaries over vacancies

    SciTech Connect

    Tschopp, Mark A.; Horstemeyer, Mark; Gao, Fei; Sun, Xin; Khaleel, Mohammad A.

    2011-05-02

    Molecular dynamics simulations of 50 Fe grain boundaries were used to understand their interaction with vacancies and self-interstitial atoms at all atomic positions within 20 °A of the boundary, which is important for designing radiation-resistant polycrystalline materials. Site-to-site variation within the boundary of both vacancy and self-interstitial formation energies is substantial, with the majority of sites having lower formation energies than in the bulk. Comparing the vacancy and self-interstitial atom binding energies for each site shows that there is an energetic driving force for interstitials to preferentially bind to grain boundary sites over vacancies. Furthermore, these results provide a valuable dataset for quantifying uncertainty bounds for various grain boundary types at the nanoscale, which can be propagated to higher scale simulations of microstructure evolution.

  20. Opposing forces of aerosol cooling and El Niño drive coral bleaching on Caribbean reefs

    PubMed Central

    Gill, Jennifer A.; Watkinson, Andrew R.; McWilliams, John P.; Côté, Isabelle M.

    2006-01-01

    Bleaching of corals as a result of elevated sea surface temperatures (SST) is rapidly becoming a primary source of stress for reefs globally; the scale and extent of this threat will depend on how the drivers of SST interact to influence bleaching patterns. We demonstrate how the opposing forces of the El Niño–Southern Oscillation (ENSO) and levels of atmospheric aerosols drive regional-scale patterns of coral bleaching across the Caribbean. When aerosol levels are low, bleaching is largely determined by El Niño strength, but high aerosol levels mitigate the effects of a severe El Niño. High aerosol levels, resulting principally from recent volcanic activity, have thus protected Caribbean reefs from more frequent widespread bleaching events but cannot be relied on to provide similar protection in the future. PMID:17116861

  1. Mining spatial information to investigate the evolution of karst rocky desertification and its human driving forces in Changshun, China.

    PubMed

    Xu, Erqi; Zhang, Hongqi; Li, Mengxian

    2013-08-01

    The processes of karst rocky desertification (KRD) have been found to cause the most severe environmental degradation in southwestern China. Understanding the driving forces that cause KRD is essential for managing and restoring the areas that it impacts. Studies of the human driving forces of KRD are limited to the county level, a specific administrative unit in China; census data are acquired at this scale, which can lead to scale biases. Changshun County is studied here as a representative area and anthropogenic influences in the county are accounted for by using Euclidean distances for the proximity to roads and settlements. We propose a standard coefficient of human influence (SOI) that standardizes the Euclidean distances for different KRD transformations to compare the effects of human activities in different areas. In Changshun County, the individual influences of roads and settlements share similar characteristics. The SOIs of improved KRD transformation types are almost negative, but the SOIs of deteriorated types are nearly positive except for one form of KRD turning to the extremely severe KRD. The results indicated that the distribution and evolution of the KRD areas from 2000 to 2010 in Changshun were affected positively by human activities (e.g., KRD restoration projects) and also negatively (e.g., by intense and irrational land use). Our results demonstrate that the spatial techniques and SOI used in this study can effectively incorporate information concerning human influences and internal KRD transformations. This provides a suitable approach for studying the relationships between human activities and KRD processes at fine scales. PMID:23685367

  2. [Land use change dynamics and driving forces of the vulnerable ecological region in northwestern Shanxi Province, China].

    PubMed

    Li, Xiu-Fen; Liu, Li-Min; Qi, Xin; Zhang, Jin-Xin; Zhao, Tong-Bin; Wang, Yi; Liu, Xue-Fen; Zhou, Yong-Bin

    2014-10-01

    By using remote sensing and GIS technology, this paper collected land use information of 1980, 1990, 2000 and 2010 and the relevant statistical data, and analyzed the characteristics of land use change and its driving forces in northwestern Shanxi Province, the typical ecological fragile area. The results showed that there were significant changes in land use patterns in the past 30 years. During 1980-1990, 1990-2000 and 2000-2010 periods, the area of farmland decreased continuously, while the areas of grassland and woodland experienced increase-decrease-increase and decrease-increase-decrease patterns of change, respectively. The areas of industrial and resident lands increased continuously, but the water body and unused land decreased. The farmland was mainly transformed to grassland and woodland, and the areas of industrial and resident lands increased from the farmland. The lost area of water body was transformed to grassland and farmland. The decrease of unused land was due to the implementation of ecological engineering and urban ex-panding. In general, the changes of land use types were significantly higher before 2000 than after 2000. The industrial and resident lands, unused land and grassland changed drastically. The relationships between land use types and driving forces indicated that population pressure and economic development led to the changes of industrial land and farmland; policy of forestry ecological engi- neering drove the changes of woodland and grassland; the drought-characterized climate was the major cause inducing the decrease of water area and hindering the restoration of forest. PMID:25796906

  3. Technique of optimization of minimum temperature driving forces in the heaters of regeneration system of a steam turbine unit

    NASA Astrophysics Data System (ADS)

    Shamarokov, A. S.; Zorin, V. M.; Dai, Fam Kuang

    2016-03-01

    At the current stage of development of nuclear power engineering, high demands on nuclear power plants (NPP), including on their economy, are made. In these conditions, improving the quality of NPP means, in particular, the need to reasonably choose the values of numerous managed parameters of technological (heat) scheme. Furthermore, the chosen values should correspond to the economic conditions of NPP operation, which are postponed usually a considerable time interval from the point of time of parameters' choice. The article presents the technique of optimization of controlled parameters of the heat circuit of a steam turbine plant for the future. Its particularity is to obtain the results depending on a complex parameter combining the external economic and operating parameters that are relatively stable under the changing economic environment. The article presents the results of optimization according to this technique of the minimum temperature driving forces in the surface heaters of the heat regeneration system of the steam turbine plant of a K-1200-6.8/50 type. For optimization, the collector-screen heaters of high and low pressure developed at the OAO All-Russia Research and Design Institute of Nuclear Power Machine Building, which, in the authors' opinion, have the certain advantages over other types of heaters, were chosen. The optimality criterion in the task was the change in annual reduced costs for NPP compared to the version accepted as the baseline one. The influence on the decision of the task of independent variables that are not included in the complex parameter was analyzed. An optimization task was decided using the alternating-variable descent method. The obtained values of minimum temperature driving forces can guide the design of new nuclear plants with a heat circuit, similar to that accepted in the considered task.

  4. Tendency to occupy a statistically dominant spatial state of the flow as a driving force for turbulent transition.

    PubMed

    Chekmarev, Sergei F

    2013-03-01

    The transition from laminar to turbulent fluid motion occurring at large Reynolds numbers is generally associated with the instability of the laminar flow. On the other hand, since the turbulent flow characteristically appears in the form of spatially localized structures (e.g., eddies) filling the flow field, a tendency to occupy such a structured state of the flow cannot be ruled out as a driving force for turbulent transition. To examine this possibility, we propose a simple analytical model that treats the flow as a collection of localized spatial structures, each of which consists of elementary cells in which the behavior of the particles (atoms or molecules) is uncorrelated. This allows us to introduce the Reynolds number, associating it with the ratio between the total phase volume for the system and that for the elementary cell. Using the principle of maximum entropy to calculate the most probable size distribution of the localized structures, we show that as the Reynolds number increases, the elementary cells group into the localized structures, which successfully explains turbulent transition and some other general properties of turbulent flows. An important feature of the present model is that a bridge between the spatial-statistical description of the flow and hydrodynamic equations is established. We show that the basic assumptions underlying the model, i.e., that the particles are indistinguishable and elementary volumes of phase space exist in which the state of the particles is uncertain, are involved in the derivation of the Navier-Stokes equation. Taking into account that the model captures essential features of turbulent flows, this suggests that the driving force for the turbulent transition is basically the same as in the present model, i.e., the tendency of the system to occupy a statistically dominant state plays a key role. The instability of the flow at high Reynolds numbers can then be a mechanism to initiate structural rearrangement of

  5. Selective nanomanipulation of fluorescent polystyrene nano-beads and single quantum dots at gold nanostructures based on the AC-dielectrophoretic force

    NASA Astrophysics Data System (ADS)

    Kim, Jinsik; Hwang, Kyo Seon; Lee, Sangyoup; Park, Jung Ho; Shin, Hyun-Joon

    2015-11-01

    We introduced the selective manipulation of polystyrene (PS) nano-beads and single quantum dots (QDs) at a gold nanostructure by using the AC-dielectrophoretic (DEP) force. Manipulation in three degrees of freedom (end-facet, side, and position-selective manipulation) was accomplished in gold nanostructures between microelectrodes. A 10 μm gap between the microelectrodes, which has a 100 nm-wide nanowire and 200 nm-wide vortex nanostructures at the inside of the gap, was fabricated, and nanostructures were not connected with the electrodes. We also performed theoretical calculations to verify the selective manipulation through the floating AC-DEP force. A sufficiently high gradient of the square of the electric field (∇|E|2, ~1019 V2 m-3) was accomplished and controlled for achieving a strong attaching force of nanoparticles using the gap between microelectrodes and nanostructures as well as the rotation of structures. Fluorescent PS nano-beads and QDs were attached at the designed end facet, side, and position of nanostructures with high selectivity. A single QD attachment was also realized at gold nanostructures, and the attached QDs were verified as single using optical ``blinking'' measurements.We introduced the selective manipulation of polystyrene (PS) nano-beads and single quantum dots (QDs) at a gold nanostructure by using the AC-dielectrophoretic (DEP) force. Manipulation in three degrees of freedom (end-facet, side, and position-selective manipulation) was accomplished in gold nanostructures between microelectrodes. A 10 μm gap between the microelectrodes, which has a 100 nm-wide nanowire and 200 nm-wide vortex nanostructures at the inside of the gap, was fabricated, and nanostructures were not connected with the electrodes. We also performed theoretical calculations to verify the selective manipulation through the floating AC-DEP force. A sufficiently high gradient of the square of the electric field (∇|E|2, ~1019 V2 m-3) was accomplished and

  6. Wading for food the driving force of the evolution of bipedalism?

    PubMed

    Kuliukas, Algis

    2002-01-01

    Evidence is accumulating that suggests that the large human brain is most likely to have evolved in littoral and estuarine habitats rich in naturally occurring essential fatty acids. This paper adds further weight to this view, suggesting that another key human trait, our bipedality might also be best explained as an adaptation to a water-side niche. Evidence is provided here that extant apes, although preferring to keep dry, go into water when driven to do so by hunger. The anecdotal evidence has suggested that they tend to do this bipedally. Here, a new empirical study of captive bonobos found them to exhibit 2% or less bipedality on the ground or in trees but over 90% when wading in water to collect food. The skeletal morphology of AL 288-1 ("Lucy") is shown to indicate a strong ability to abduct and adduct the femur. These traits, together with a remarkably platypelloid pelvis, have not yet been adequately explained by terrestrial or arboreal models for early bipedalism but are consistent with those expected in an ape that adopted a specialist side-to-side 'ice-skating' or sideways wading mode. It is argued that this explanation of A. afarensis locomotor morphology is more parsimonious than others which have plainly failed to produce a consensus. Microwear evidence of Australopithecus dentition is also presented as evidence that the drive for such a wading form of locomotion might well have been waterside foods. This model obtains further support from the paleo-habitats of the earliest known bipeds, which are consistent with the hypothesis that wading contributed to the adaptive pressure towards bipedality. PMID:12617279

  7. Prescription drug advertising: is it a driving force on drug pricing?

    PubMed

    Millstein, Lloyd G

    2003-01-01

    It has been shown that drug companies will sell more drugs when they use DTC advertising, but it is also true that many consumers who are suffering--unaware there is help for their symptoms--will learn from these ads that help is available. Advertising to consumers, like advertising to professionals, will continue to be one of the best methods of providing information. Of course, healthcare professionals also have the sales representatives, their colleagues, medical journals, and medical conventions as additional options for needed information. The consumer may or may not use other methods, such as the Internet, the library or friends or family, but the advertising is a starting point for a dialogue. If the DTC ad provides consumers with "information," which is different from "advertising," the drug company will be providing a worthwhile service to consumers and potential patients. No doubt consumers will begin demanding higher quality information from DTC ads and will frown upon the ads that are blatantly trying just to sell a drug. It will also reap the benefits of improved consumer awareness and patient compliance. A DTC ad that is consumer-friendly, does not use fear appeal, is educational in tone, and downplays the "hard sell" and hype will go a long way in offering important information to the casual observer. Oversight by the FDA will ensure the information meets the requirements they have set down for prescription drug advertising. That is, advertising will be truthful and fairly balanced and will meet what the government, consumers and, no doubt, the medical community wants. Attempting to control drug costs, by controlling advertising, will not be an easy task. This has an implication across all product areas, not just drugs. DTC advertising has become a lightening rod for cost containment issues, but is it alone driving demand for prescription products? I don't think so. PMID:14983621

  8. Environmental disruption of host–microbe co-adaptation as a potential driving force in evolution

    PubMed Central

    Soen, Yoav

    2014-01-01

    The microbiome is known to have a profound effect on the development, physiology and health of its host. Whether and how it also contributes to evolutionary diversification of the host is, however, unclear. Here we hypothesize that disruption of the microbiome by new stressful environments interferes with host–microbe co-adaptation, contributes to host destabilization, and can drive irreversible changes in the host prior to its genetic adaptation. This hypothesis is based on three presumptions: (1) the microbiome consists of heritable partners which contribute to the stability (canalization) of host development and physiology in frequently encountered environments, (2) upon encountering a stressful new environment, the microbiome adapts much faster than the host, and (3) this differential response disrupts cooperation, contributes to host destabilization and promotes reciprocal changes in the host and its microbiome. This dynamic imbalance relaxes as the host and its microbiome establish a new equilibrium state in which they are adapted to one another and to the altered environment. Over long time in this new environment, the changes in the microbiome contribute to the canalization of the altered state. This scenario supports stability of the adapted patterns, while promoting variability which may be beneficial in new stressful conditions, thus allowing the organism to balance stability and flexibility based on contextual demand. Additionally, interaction between heritable microbial and epigenetic/physiological changes can promote new outcomes which persist over a wide range of timescales. A sufficiently persistent stress can further induce irreversible changes in the microbiome which may permanently alter the organism prior to genetic changes in the host. Epigenetic and microbial changes therefore provide a potential infrastructure for causal links between immediate responses to new environments and longer-term establishment of evolutionary adaptations. PMID

  9. Spatial Pattern of Land Use Change and Its Driving Force in Jiangsu Province

    PubMed Central

    Du, Xindong; Jin, Xiaobin; Yang, Xilian; Yang, Xuhong; Zhou, Yinkang

    2014-01-01

    Scientific interpretation of the mechanism of land use change is important for government planning and management activities. This study analyzes the land use change in Jiangsu Province using three land use maps of 2000, 2005 and 2008. The study results show that there was a significant change in land use. The change was mainly characterized by a continuous built-up land expansion primarily at the expense of cropland loss, and the trend became increasingly rapid. There was an obvious regional difference, as most of the cropland loss or built-up land expansion took place in southern Jiangsu, where the rate of built-up land expansion was faster than in central and northern Jiangsu. Meanwhile, the spatial pattern changed remarkably; in general, the number of patches (NumP) showed a declining trend, and the mean patch size (MPS) and patch size standard deviation (PSSD) displayed increase trends. Furthermore, the relative importance of selected driven factors was identified by principal component analysis (PCA) and general linear model (GLM). The results showed that not only the relative importance of a specific driving factor may vary, but the driven factors may as well. The most important driven factor changed from urban population (UP), secondary gross domestic product (SGDP) and gross domestic product (GDP) during 2000–2005 to resident population (RP), population density (POD) and UP during 2005–2008, and the deviance explained (DE) decreased from 91.60% to 81.04%. Policies also had significant impacts on land use change, which can be divided into direct and indirect impacts. Development policies usually had indirect impacts, particularly economic development policies, which promote the economic development to cause land use change, while land management policies had direct impacts. We suggest that the government should think comprehensively and cautiously when proposing a new development strategy or plan. PMID:24646864

  10. Experiments using atmospheric forcing from a FGGE analysis to drive an upper ocean model

    NASA Technical Reports Server (NTRS)

    Camerlengo, A.

    1983-01-01

    Results are presented of a series of numerical experiments in which an upper ocean model is driven by surface heat fluxes and stress fields derived from the FGGE SOP-1 GLAS analysis/forecast system (Halem, et al., 1982). The model results show that most changes in the mixed layer height and horizontal velocity occurs in the first days. On the other hand, changes in the temperature field take a longer time to develop. In the most realistic case (real initial conditions, instantaneous forcing fields from the atmospheric analysis), the resulting changes in temperature were larger than observed and the correlation between observed and predicted changes was poor. The deficiency in the forecast of SST changes may be due to several factors: lack of sufficient ocean resolution, improper initialization, lack of feedback between the ocean and the atmosphere and the absence of transports by the strong boundary currents, and perhaps unrealistic surface fluxes of heat and momentum. Unless these problems are alleviated it is not reasonable to perform coupled atmospheric ocean forecasts.

  11. Biomechanical force in blood development: extrinsic physical cues drive pro-hematopoietic signaling

    PubMed Central

    Lee, Hyun Jung; Li, Nan; Evans, Siobahn M.; Diaz, Miguel F.; Wenzel, Pamela L.

    2013-01-01

    The hematopoietic system is dynamic during development and in adulthood, undergoing countless spatial and temporal transitions during the course of one’s life. Microenvironmental cues in the many unique hematopoietic niches differ, characterized by distinct soluble molecules, membrane-bound factors, and biophysical features that meet the changing needs of the blood system. Research from the last decade has revealed the importance of substrate elasticity and biomechanical force in determination of stem cell fate. Our understanding of the role of these factors in hematopoiesis is still relatively poor; however, the developmental origin of blood cells from the endothelium promts a model for comparison. Many endothelial mechanical sensors and second messenger systems may also determine hematopoietic stem cell fate, self renewal, and homing behaviors. Further, the intimate contact of hematopoietic cells with mechanosensitive cell types, including osteoblasts, endothelial cells, mesenchymal stem cells, and pericytes, places them in close proximity to paracrine signaling downstream of mechanical signals. The objective of this review is to present an overview of the sensors and intracellular signaling pathways activated by mechanical cues and highlight the role of mechanotransductive pathways in hematopoiesis. PMID:23850217

  12. Structural Fe(II) Oxidation in Biotite by an Ectomycorrhizal Fungi Drives Mechanical Forcing.

    PubMed

    Bonneville, Steeve; Bray, Andrew W; Benning, Liane G

    2016-06-01

    Microorganisms are essential agents of Earth's soil weathering engine who help transform primary rock-forming minerals into soils. Mycorrhizal fungi, with their vast filamentous networks in symbiosis with the roots of most plants can alter a large number of minerals via local acidification, targeted excretion of ligands, submicron-scale biomechanical forcing, and mobilization of Mg, Fe, Al, and K at the hypha-biotite interface. Here, we present experimental evidence that Paxillus involutus-a basidiomycete fungus-in ectomycorrhizal symbiosis with Scots pine (Pinus sylvestris), is able to oxidize a substantial amount of structural Fe(II) in biotite. Iron redox chemistry, quantified by X-ray absorption near edge spectra on 13 fungi-biotite sections along three distinct hypha colonizing the [001] basal plane of biotite, revealed variable but extensive Fe(II) oxidation up to ∼2 μm in depth and a Fe(III)/Fetotal ratio of up to ∼0.8. The growth of Fe(III) hydroxide implies a volumetric change and a strain within the biotite lattice potentially large enough to induce microcrack formation, which are abundant below the hypha-biotite interface. This Fe(II) oxidation also leads to the formation of a large pool of Fe(III) (i.e., structural Fe(III) and Fe(III) oxyhydroxides) within biotite that could participate in the Fe redox cycling in soils. PMID:27128742

  13. Selective pressure against horizontally acquired prokaryotic genes as a driving force of plastid evolution.

    PubMed

    Llorente, Briardo; de Souza, Flavio S J; Soto, Gabriela; Meyer, Cristian; Alonso, Guillermo D; Flawiá, Mirtha M; Bravo-Almonacid, Fernando; Ayub, Nicolás D; Rodríguez-Concepción, Manuel

    2016-01-01

    The plastid organelle comprises a high proportion of nucleus-encoded proteins that were acquired from different prokaryotic donors via independent horizontal gene transfers following its primary endosymbiotic origin. What forces drove the targeting of these alien proteins to the plastid remains an unresolved evolutionary question. To better understand this process we screened for suitable candidate proteins to recapitulate their prokaryote-to-eukaryote transition. Here we identify the ancient horizontal transfer of a bacterial polyphenol oxidase (PPO) gene to the nuclear genome of an early land plant ancestor and infer the possible mechanism behind the plastidial localization of the encoded enzyme. Arabidopsis plants expressing PPO versions either lacking or harbouring a plastid-targeting signal allowed examining fitness consequences associated with its subcellular localization. Markedly, a deleterious effect on plant growth was highly correlated with PPO activity only when producing the non-targeted enzyme, suggesting that selection favoured the fixation of plastid-targeted protein versions. Our results reveal a possible evolutionary mechanism of how selection against heterologous genes encoding cytosolic proteins contributed in incrementing plastid proteome complexity from non-endosymbiotic gene sources, a process that may also impact mitochondrial evolution. PMID:26750147

  14. Driving Forces for Bicarbonate Transport in the Cyanobacterium Synechococcus R-2 (PCC 7942).

    PubMed Central

    Ritchie, R. J.; Nadolny, C.; Larkum, AWD.

    1996-01-01

    Air-grown Synechococcus R-2 (PCC 7942) cultures grown in BG-11 medium are very alkaline (outside pH is 10.0) and use HCO3- as their inorganic carbon source. The cells showed a dependence on Na+ for photosynthesis, but low Na+ conditions (1 mol m-3) were sufficient to support saturating photosynthesis. The intracellular dissolved inorganic carbon in the light was greater than 20 mol m-3 in both low-Na+ conditions and in BG-11 medium containing the usual [Na+] (24 mol m-3, designated high-Na+ conditions). The electrochemical potential for HCO3- in the light was in excess of 25 kJ mol-1, even in high-Na+ conditions. The Na+-motive force was greater than -12 kJ mol-1 under both Na+ conditions. On thermodynamic grounds, an Na+-driven co-port process would need to have a stoichiometry of 2 or greater ([greater than or equal to]2Na+ in/HCO3-1 in), but we show that Na+ or K+ fluxes cannot be linked to HCO3- transport. Na+ and K+ fluxes were unaffected by the presence or absence of dissolved inorganic carbon. In low-Na+ conditions, Na+ fluxes are too low to support the observed net 14C-carbon fixation rate. Active transport of HCO3- hyperpolarizes (not depolarizes) the membrane potential. PMID:12226464

  15. Selective pressure against horizontally acquired prokaryotic genes as a driving force of plastid evolution

    PubMed Central

    Llorente, Briardo; de Souza, Flavio S. J.; Soto, Gabriela; Meyer, Cristian; Alonso, Guillermo D.; Flawiá, Mirtha M.; Bravo-Almonacid, Fernando; Ayub, Nicolás D.; Rodríguez-Concepción, Manuel

    2016-01-01

    The plastid organelle comprises a high proportion of nucleus-encoded proteins that were acquired from different prokaryotic donors via independent horizontal gene transfers following its primary endosymbiotic origin. What forces drove the targeting of these alien proteins to the plastid remains an unresolved evolutionary question. To better understand this process we screened for suitable candidate proteins to recapitulate their prokaryote-to-eukaryote transition. Here we identify the ancient horizontal transfer of a bacterial polyphenol oxidase (PPO) gene to the nuclear genome of an early land plant ancestor and infer the possible mechanism behind the plastidial localization of the encoded enzyme. Arabidopsis plants expressing PPO versions either lacking or harbouring a plastid-targeting signal allowed examining fitness consequences associated with its subcellular localization. Markedly, a deleterious effect on plant growth was highly correlated with PPO activity only when producing the non-targeted enzyme, suggesting that selection favoured the fixation of plastid-targeted protein versions. Our results reveal a possible evolutionary mechanism of how selection against heterologous genes encoding cytosolic proteins contributed in incrementing plastid proteome complexity from non-endosymbiotic gene sources, a process that may also impact mitochondrial evolution. PMID:26750147

  16. Investigation of Adiabatic Shear Bands in Thick-Walled Cylinders Collapsed by Electro-Magnetic Driving Forces

    NASA Astrophysics Data System (ADS)

    Lovinger, Z.; Rikanati, A.; Rittel, D.; Rosenberg, Z.

    2009-12-01

    The Thick-Walled Cylinder technique, reported in the literature, employs an explosive cylinder to create the driving force, collapsing the cylindrical sample. This experimental set-up has been established as a controlled and repeatable technique to create and study multiple adiabatic shear bands. Searching to establish a simpler experimental platform to perform large sets of experiments, we have designed an Electro-Magnetic (EM) set-up for the collapse of thick walled cylinders. The EM setup is based on a pulsed current generator using a capacitor bank system. The specimen is an assembly of coaxial cylinders, where the inner and outer cylinders, each attached to an opposite pole, are short-circuited. Upon discharge, a high current flows through the cylinders, in opposite directions, creating repulsive magnetic forces between them. This work presents the design procedure of the specimens using numerical simulations as well as some results for SS304L thick-walled specimens, using this setup. The spatial distribution of the multiple adiabatic shear bands in these experiments is in good agreement with that reported in the literature for the explosive driven experiments with SS304L specimens. Our numerical simulations show good agreement with the experimental results for both global behaviour and shear band distribution.

  17. Spatial analysis and quantification of the thermodynamic driving forces in protein-ligand binding: binding site variability.

    PubMed

    Raman, E Prabhu; MacKerell, Alexander D

    2015-02-25

    The thermodynamic driving forces behind small molecule-protein binding are still not well-understood, including the variability of those forces associated with different types of ligands in different binding pockets. To better understand these phenomena we calculate spatially resolved thermodynamic contributions of the different molecular degrees of freedom for the binding of propane and methanol to multiple pockets on the proteins Factor Xa and p38 MAP kinase. Binding thermodynamics are computed using a statistical thermodynamics based end-point method applied on a canonical ensemble comprising the protein-ligand complexes and the corresponding free states in an explicit solvent environment. Energetic and entropic contributions of water and ligand degrees of freedom computed from the configurational ensemble provide an unprecedented level of detail into the mechanisms of binding. Direct protein-ligand interaction energies play a significant role in both nonpolar and polar binding, which is comparable to water reorganization energy. Loss of interactions with water upon binding strongly compensates these contributions leading to relatively small binding enthalpies. For both solutes, the entropy of water reorganization is found to favor binding in agreement with the classical view of the "hydrophobic effect". Depending on the specifics of the binding pocket, both energy-entropy compensation and reinforcement mechanisms are observed. It is notable to have the ability to visualize the spatial distribution of the thermodynamic contributions to binding at atomic resolution showing significant differences in the thermodynamic contributions of water to the binding of propane versus methanol. PMID:25625202

  18. Spatial Analysis and Quantification of the Thermodynamic Driving Forces in Protein-Ligand Binding: Binding Site Variability

    PubMed Central

    Raman, E. Prabhu; MacKerell, Alexander D.

    2015-01-01

    The thermodynamic driving forces behind small molecule-protein binding are still not well understood, including the variability of those forces associated with different types of ligands in different binding pockets. To better understand these phenomena we calculate spatially resolved thermodynamic contributions of the different molecular degrees of freedom for the binding of propane and methanol to multiple pockets on the proteins Factor Xa and p38 MAP kinase. Binding thermodynamics are computed using a statistical thermodynamics based end-point method applied on a canonical ensemble comprising the protein-ligand complexes and the corresponding free states in an explicit solvent environment. Energetic and entropic contributions of water and ligand degrees of freedom computed from the configurational ensemble provides an unprecedented level of detail into the mechanisms of binding. Direct protein-ligand interaction energies play a significant role in both non-polar and polar binding, which is comparable to water reorganization energy. Loss of interactions with water upon binding strongly compensates these contributions leading to relatively small binding enthalpies. For both solutes, the entropy of water reorganization is found to favor binding in agreement with the classical view of the “hydrophobic effect”. Depending on the specifics of the binding pocket, both energy-entropy compensation and reinforcement mechanisms are observed. Notable is the ability to visualize the spatial distribution of the thermodynamic contributions to binding at atomic resolution showing significant differences in the thermodynamic contributions of water to the binding of propane versus methanol. PMID:25625202

  19. Medical school survival versus social responsibility: finances as a driving force.

    PubMed

    Brandt, E N

    1989-01-01

    Medical educators are an interesting group of people. They thrive on new knowledge. They get excited and enthusiastic, and readily adopt new ways when the evidence is sufficient. Yet, at the same time, they resist with great vehemence change in the way they do their business. Ask how often the curriculum structure is examined. Indeed, the function of most curriculum committees is to ensure that that does not happen. Ask how often the criteria for medical school admission are examined, especially with respect to the knowledge requirements. Ask how often the faculty discusses, or even examines, the expectations of society as they are expressed by alumni, legislators, or members of the public. Ask how often faculties try to determine strategies for dealing with all of these external forces. Are those strategies approached with the same degree of objectivity and data-gathering skills that would be used in examining new therapeutic regimens? Medical educators are talented, creative people. They have a very large appetite for information and great ambition to be as fine academicians as possible. It is those characteristics that have served them well, as students and as responsible academicians. Indeed, the great strength of medical education, in my view, is that medical schools take some very bright people called faculty and some very bright people called students, mix them together for four years, and graduate a group of very smart people who will then spend three years or more mixed up with some very bright and creative people. That is a strength that can-not lost. Will the future allow us to continue that in an equally effective manner? PMID:2734361

  20. Force.

    ERIC Educational Resources Information Center

    Gamble, Reed

    1989-01-01

    Discusses pupil misconceptions concerning forces. Summarizes some of Assessment of Performance Unit's findings on meaning of (1) force, (2) force and motion in one dimension and two dimensions, and (3) Newton's second law. (YP)

  1. Multi Satellites Monitoring of Land Use/Cover Change and Its Driving Forces in Kashgar Region, China

    NASA Astrophysics Data System (ADS)

    Maimaitiaili, Ayisulitan; Aji, xiaokaiti; Kondoh, Akihiko

    2016-04-01

    Multi Satellites Monitoring of Land Use/Cover Change and Its Driving Forces in Kashgar Region, China Ayisulitan Maimaitiaili1, Xiaokaiti Aji2 Akihiko Kondoh2 1Graduate School of Science, Chiba University, Japan 2Center for Environmental Remote Sensing, Chiba University The spatio-temporal changes of Land Use/Cover (LUCC) and its driving forces in Kashgar region, Xinjiang Province, China, are investigated by using satellite remote sensing and a geographical information system (GIS). Main goal of this paper is to quantify the drivers of LUCC. First, considering lack of the Land Cover (LC) map in whole study area, we produced LC map by using Landsat images. Land use information from Landsat data was collected using maximum likelihood classification method. Land use change was studied based on the change detection method of land use types. Second, because the snow provides a key water resources for stream flow, agricultural production and drinking water for sustaining large population in Kashgar region, snow cover are estimated by Spot Vegetation data. Normalized Difference Snow Index (NDSI) algorithm are applied to make snow cover map, which is used to screen the LUCC and climate change. The best agreement is found with threshold value of NDSI≥0.2 to generate multi-temporal snow cover and snowmelt maps. Third, driving forces are systematically identified by LC maps and statistical data such as climate and socio-economic data, regarding to i) the climate changes and ii) socioeconomic development that the spatial correlation among LUCC, snow cover change, climate and socioeconomic changes are quantified by using liner regression model and negative / positive trend analysis. Our results showed that water bodies, bare land and grass land have decreasing notably. By contrast, crop land and urban area have continually increasing significantly, which are dominated in study area. The area of snow/ice have fluctuated and has strong seasonal trends, total annual snow cover

  2. Land use/cover changes in European mountain areas: identifying links between global driving forces and local consequences

    NASA Astrophysics Data System (ADS)

    Malek, Žiga; Schröter, Dagmar; Glade, Thomas

    2013-04-01

    Minor land use/cover changes in mountain areas can aggravate the consequences of hydro-meteorological hazards such as landslides, avalanches, rockfall and flash floods. What is more, they change the provisioning of ecosystem services; also as their recovery after anthropogenic induced changes in mountains are slower or not occurring at all due to harsh climate and soil conditions. Examples of these changes are urbanization in high risk areas or deforestation on slopes. To understand the driving forces behind land use/cover changes in European mountain areas, the focus is on the two case study areas: The Val Canale valley in the Italian Alps and the Buzau valley in the Romanian Carpathians. Land use/cover changes were analyzed in the recent decades applying various remote sensing techniques, such as satellite imagery classification and visual interpretation, as well as integration of various databases (e.g. forestry, spatial planning and cadaster plans). Instead of identifying the statistical significance of particular variables (e.g. population change), the links between different driving forces of global change (e.g. political and policy changes, infrastructural plans) and local socio-economic variables were investigated further through interviewing local and regional stakeholders. The results show how both areas differ in the consequences of global changes in terms of land use/cover change. The Italian area witnessed a trajectory from a commercially active and competitive area, to an area with a large portion of abandoned commercial, customs, industrial and mining zones. These processes were accompanied by the expansion of settlements comprised mostly of secondary housing on areas with high risk, resulting in catastrophic consequences in recent flash floods and debris flows events. The Romanian site also witnessed a breakdown of local commercial and industrial activities. Together with land ownership reforms, this has resulted in the emergence of subsistence

  3. Mantle viscosity - A comparison of models from postglacial rebound and from the geoid, plate driving forces, and advected heat flux

    NASA Technical Reports Server (NTRS)

    Hager, Bradford H.

    1991-01-01

    Models of the radial variation of effective viscosity inferred from the earth's response to surface loads associated with Pleistocene deglaciation are compared to structures inferred from models of geodynamic phenomena associated with convection: the geoid, plate-driving forces, and advected heat flux. While observations of the earth's response to surface loads do not have sufficient resolution to justify more than two viscous layers, adequately matching the observed long-wavelength geoid anomalies associated with density contrasts in the lower mantle (inferred from seismic tomography) and in the upper mantle (inferred from a model of subducted slabs) requires more structure. It is possible to explain the geoid, observed plate velocities, the advected heat flux in the lower mantle, and relative sea-level variations in oceanic regions, all with a mantle with a high-viscosity/elastic lid, an asthenospheric channel of 2 x 10 exp 19 Pa s from 100 to 400-km depth, a 6 x 10 exp 20 Pa s transition zone, and a lower mantle of 6 x 10 exp 21 Pa s. The uplift history of Australia, Fennoscandia, and Laurentia can be explained with an asthenospheric viscosity less than a factor of 10 higher. Lateral variations in lower mantle viscosity are not required. Transient creep appears to be unimportant for the recent response-to-surface loads from Pleistocene deglaciation.

  4. Solvent driving force ensures fast formation of a persistent and well-separated radical pair in plant cryptochrome.

    PubMed

    Lüdemann, Gesa; Solov'yov, Ilia A; Kubař, Tomáš; Elstner, Marcus

    2015-01-28

    The photoreceptor protein cryptochrome is thought to host, upon light absorption, a radical pair that is sensitive to very weak magnetic fields, endowing migratory birds with a magnetic compass sense. The molecular mechanism that leads to formation of a stabilized, magnetic field sensitive radical pair has despite various theoretical and experimental efforts not been unambiguously identified yet. We challenge this unambiguity through a unique quantum mechanical molecular dynamics approach where we perform electron transfer dynamics simulations taking into account the motion of the protein upon the electron transfer. This approach allows us to follow the time evolution of the electron transfer in an unbiased fashion and to reveal the molecular driving force that ensures fast electron transfer in cryptochrome guaranteeing formation of a persistent radical pair suitable for magnetoreception. We argue that this unraveled molecular mechanism is a general principle inherent to all proteins of the cryptochrome/photolyase family and that cryptochromes are, therefore, tailored to potentially function as efficient chemical magnetoreceptors. PMID:25535848

  5. Fixed negative charge and the Donnan effect: a description of the driving forces associated with brain tissue swelling and oedema.

    PubMed

    Elkin, Benjamin S; Shaik, Mohammed A; Morrison, Barclay

    2010-02-13

    Cerebral oedema or brain tissue swelling is a significant complication following traumatic brain injury or stroke that can increase the intracranial pressure (ICP) and impair blood flow. Here, we have identified a potential driver of oedema: the negatively charged molecules fixed within cells. This fixed charge density (FCD), once exposed, could increase ICP through the Donnan effect. We have shown that metabolic processes and membrane integrity are required for concealing this FCD as slices of rat cortex swelled immediately (within 30 min) following dissection if treated with 2 deoxyglucose + cyanide (2DG+CN) or Triton X-100. Slices given ample oxygen and glucose, however, did not swell significantly. We also found that dead brain tissue swells and shrinks in response to changes in ionic strength of the bathing medium, which suggests that the Donnan effect is capable of pressurizing and swelling brain tissue. As predicted, a non-ionic osmolyte, 1,2 propanediol, elicited no volume change at 2000 x 10(-3) osmoles l(-1) (Osm). Swelling data were well described by triphasic mixture theory with the calculated reference state FCD similar to that measured with a 1,9 dimethylmethylene blue assay. Taken together, these data suggest that intracellular fixed charges may contribute to the driving forces responsible for brain swelling. PMID:20047940

  6. Invasion of Nostocales (cyanobacteria) to Subtropical and Temperate Freshwater Lakes – Physiological, Regional, and Global Driving Forces

    PubMed Central

    Sukenik, Assaf; Hadas, Ora; Kaplan, Aaron; Quesada, Antonio

    2012-01-01

    Similar to the increased number of studies on invasive plants and animals in terrestrial and aquatic ecosystems, many reports were recently published on the invasion of Nostocales (cyanobacteria) to freshwater environments worldwide. Invasion and proliferation of Nostocales in new habitats have the potential to significantly alter the structure of the native community and to modify ecosystem functioning. But most importantly, they influence the water quality due to a variety of toxic compounds that some species produce. Therefore a special attention was given to the invasion and persistence of toxic cyanobacteria in many aquatic ecosystems. Here we summarize the currently published records on the invasion of two Nostocales genera, Cylindrospermopsis and Aphanizomenon, to lakes and water reservoirs in subtropical and temperate zones. These invading species possess traits thought to be common to many invasive organisms: high growth rate, high resource utilization efficiency and overall superior competitive abilities over native species when local conditions vary. Assuming that dispersion routes of cyanobacteria have not been changed much in recent decades, their recent establishment and proliferation in new habitats indicate changes in the environment under which they can exploit their physiological advantage over the native phytoplankton population. In many cases, global warming was identified as the major driving force for the invasion of Nostocales. Due to this uncontrollable trend, invasive Nostocales species are expected to maintain their presence in new habitats and further expand to new environments. In other cases, regional changes in nutrient loads and in biotic conditions were attributed to the invasion events. PMID:22408640

  7. Driving forces of individual BVOC emissions from a spruce tree in Central Germany; results from a dynamic enclosure study.

    NASA Astrophysics Data System (ADS)

    Bourtsoukidis, S.; Dittmann, A.; Jacobi, S.; Bonn, B.

    2012-04-01

    We have conducted seasonal ambient and emission measurements of a series of biogenic VOCs such as monoterpenes (MT), sesquiterpenes (SQT), isoprene, methanol, methyl chavicol and acetaldehyde. Therefore a plant enclosure technique was applied in order to investigate a Central European spruce forest and its emissions responses to meteorological and environmental parameters. A healthy ≈15m tall Norway spruce tree was selected and a vegetation enclosure technique was applied from April to November 2011. VOCs are measured by PTR-MS, while samples have also been analyzed with GC-MS (Gas Chromatography - Mass Spectrometry) techniques for intercomparison and identification of individual VOCs. E/N ratio was adjusted at 117Td[2] and the primary ion signal (H3O+) was continuously above 4×10^7cps, implying a high sensitivity to our measurements. Temperature, relative humidity, ozone, photosynthetic active radiation (PAR) and CO2 concentrations were continuously measured inside the plant cuvette. Meteorological and environmental parameters (radiation, atmospheric pressure, wind velocity, wind direction, temperature, O3, relative humidity, soil moisture, precipitation, global radiation, H2O, NO, NO2) were measured by HLUG (Hessian Agency for Environment and Geology) and DWD (German Weather Service), 50 meters away from the measuring site. In a peculiar season, which was characterized by a warm spring (temperature anomaly >40C), a wet summer (precipitation anomaly 126-150%) and an extremely dry autumn (precipitation anomaly <50%), VOC emissions were analyzed and studied in order to discern different driving forces for the individual compounds. The suggested[3] empirical beta factor for MT found to be in a reasonable range but the temperature dependency was almost double for daytime compared to nighttime measurements, suggesting that light is also influencing MT emissions. On the contrary, SQT emissions showed similar temperature dependency for both day and night measurements

  8. Comparison of the driving forces of spring phenology among savanna landscapes by including combined spatial and temporal heterogeneity

    NASA Astrophysics Data System (ADS)

    Zhu, Likai; Southworth, Jane; Meng, Jijun

    2015-10-01

    Understanding spatial and temporal dynamics of land surface phenology (LSP) and its driving forces are critical for providing information relevant to short- and long-term decision making, particularly as it relates to climate response planning. With the third generation Global Inventory Monitoring and Modeling System (GIMMS3g) Normalized Difference Vegetation Index (NDVI) data and environmental data from multiple sources, we investigated the spatio-temporal changes in the start of the growing season (SOS) in southern African savannas from 1982 through 2010 and determined its linkage to environmental factors using spatial panel data models. Overall, the SOS occurs earlier in the north compared to the south. This relates in part to the differences in ecosystems, with northern areas representing high rainfall and dense tree cover (mainly tree savannas), whereas the south has lower rainfall and sparse tree cover (mainly bush and grass savannas). From 1982 to 2010, an advanced trend was observed predominantly in the tree savanna areas of the north, whereas a delayed trend was chiefly found in the floodplain of the north and bush/grass savannas of the south. Different environmental drivers were detected within tree- and grass-dominated savannas, with a critical division being represented by the 800 mm isohyet. Our results supported the importance of water as a driver in this water-limited system, specifically preseason soil moisture, in determining the SOS in these water-limited, grass-dominated savannas. In addition, the research pointed to other, often overlooked, effects of preseason maximum and minimum temperatures on the SOS across the entire region. Higher preseason maximum temperatures led to an advance of the SOS, whereas the opposite effects of preseason minimum temperature were observed. With the rapid increase in global change research, this work will prove helpful for managing savanna landscapes and key to predicting how projected climate changes will affect

  9. Volcanism of the Central Atlantic Magmatic Province as a potential driving force in the end-Triassic mass extinction

    NASA Astrophysics Data System (ADS)

    Pálfy, József

    Radiometric dating suggests that eruptions in the Central Atlantic magmatic province (CAMP) are synchronous with the ˜200 Ma end-Triassic mass extinction. Although stratigraphic evidence for major flows prior to the extinction horizon is still lacking, the vast extent of the province allows the assumption of cause-and-effect relationship between volcanism and extinction, mediated by drastic environmental change. A recently recognized negative carbon isotope anomaly at the Triassic-Jurassic boundary is interpreted to reflect combined effects of volcanically derived CO2 input, methane release through dissociation of gas hydrates in a global warming episode, and a possible marine productivity crisis. Maximum duration of the Rhaetian stage is estimated as only 2 m.y., and the isotope event appears short, lasting for less than 100 k.y. A variety of marine and terrestrial fossil groups (e.g., radiolarians, corals, bivalves, and plants) experienced correlated and sudden extinction at the end of Triassic, although some groups (e.g., ammonoids and conodonts) underwent a prolonged period of declining diversity. Post-extinction faunas and floras are cosmopolitan. Biotic recovery was delayed and the earliest Hettangian is a lag phase characterized by low diversity, possibly due to sustained environmental stress. The hypothesis of CAMP as the principal driving force in the end-Triassic extinction appears more consistent with paleontological and isotopic observations than alternative models. The temporally adjacent large igneous provinces, the Siberian Traps at the Permian-Triassic boundary and the Early Jurassic Karoo-Ferrar province, are also linked to extinction events, albeit of differing magnitude.

  10. Long-term dynamics in land resource use and the driving forces in the Beressa watershed, highlands of Ethiopia.

    PubMed

    Amsalu, Aklilu; Stroosnijder, Leo; de Graaff, Jan

    2007-06-01

    Land degradation in the Ethiopian highlands is considered to be one of the major problems threatening agricultural development and food security in the country. However, knowledge about the forces driving the long-term dynamics in land resources use is limited. This research integrates biophysical information with socio-economic processes and policy changes to examine the dynamics of land resource use and farmers' livelihoods in the Beressa watershed for over 40 years during the second half of the 20th century. It was found that there have been substantial dynamics in land resource use in the area. The natural vegetation cover has been extensively cleared, although most of the cleared areas have since been replaced with plantations. Grazing land has expanded remarkably at the expense of cropland and bare land. However, the expansion of cropland was minimal over the 43-year period despite a quadrupling of the population density. Yields have not increased to compensate for the reduction in per capita cropland, and the soil quality appears to be not that good. Though the farmers perceived it otherwise, the long-term rainfall pattern has improved. In response to soil degradation, water shortage, socio-economic and policy changes, farmers have tended to gradually change from annual cropping to tree planting and livestock production to cope with the problems of soil degradation, water scarcity and smaller farms. Income diversification through the sale of wood and cattle dung is becoming a major livelihood strategy. Apparently, however, little attention has been paid to investments in soil and water conservation (SWC) and local soil fertility amendments. In particular, increased erosion and related high nutrient losses in sediments, as well as the removal of potentially available soil nutrients through the sale of manure threatens to damage agricultural sustainability in the area. PMID:16959397

  11. Comparison of the driving forces of spring phenology among savanna landscapes by including combined spatial and temporal heterogeneity.

    PubMed

    Zhu, Likai; Southworth, Jane; Meng, Jijun

    2015-10-01

    Understanding spatial and temporal dynamics of land surface phenology (LSP) and its driving forces are critical for providing information relevant to short- and long-term decision making, particularly as it relates to climate response planning. With the third generation Global Inventory Monitoring and Modeling System (GIMMS3g) Normalized Difference Vegetation Index (NDVI) data and environmental data from multiple sources, we investigated the spatio-temporal changes in the start of the growing season (SOS) in southern African savannas from 1982 through 2010 and determined its linkage to environmental factors using spatial panel data models. Overall, the SOS occurs earlier in the north compared to the south. This relates in part to the differences in ecosystems, with northern areas representing high rainfall and dense tree cover (mainly tree savannas), whereas the south has lower rainfall and sparse tree cover (mainly bush and grass savannas). From 1982 to 2010, an advanced trend was observed predominantly in the tree savanna areas of the north, whereas a delayed trend was chiefly found in the floodplain of the north and bush/grass savannas of the south. Different environmental drivers were detected within tree- and grass-dominated savannas, with a critical division being represented by the 800 mm isohyet. Our results supported the importance of water as a driver in this water-limited system, specifically preseason soil moisture, in determining the SOS in these water-limited, grass-dominated savannas. In addition, the research pointed to other, often overlooked, effects of preseason maximum and minimum temperatures on the SOS across the entire region. Higher preseason maximum temperatures led to an advance of the SOS, whereas the opposite effects of preseason minimum temperature were observed. With the rapid increase in global change research, this work will prove helpful for managing savanna landscapes and key to predicting how projected climate changes will affect

  12. Probing into the Supramolecular Driving Force of an Amphiphilic β-Cyclodextrin Dimer in Various Solvents: Host-Guest Recognition or Hydrophilic-Hydrophobic Interaction?

    PubMed

    Bai, Yang; Fan, Xiao-dong; Yao, Hao; Yang, Zhen; Liu, Ting-ting; Zhang, Hai-tao; Zhang, Wan-bin; Tian, Wei

    2015-09-01

    Tuning of the morphology and size of supramolecular self-assemblies is of theoretical and practical significance. To date, supramolecular driving forces in different solvents remain unclear. In this study, we first synthesized an amphiphilic β-cyclodextrin (β-CD) dimer that consists of one hydrophobic ibuprofen (Ibu) and two hydrophilic β-CD moieties (i.e., Ibu-CD2). Ibu-CD2 possesses double supramolecular driving forces, namely, the host-guest recognition and hydrophilic-hydrophobic interaction. The host-guest interaction of Ibu-CD2 induced the formation of branched supramolecular polymers (SPs) in pure water, whereas the hydrophilic-hydrophobic interaction generated spherical or irregular micelles in water/organic mixtures. The SP size increased with the increase in Ibu-CD2 concentration in pure water. By contrast, the size of micelles decreased with the increase in volume ratio of water in mixtures. PMID:26301920

  13. DropBot: An open-source digital microfluidic control system with precise control of electrostatic driving force and instantaneous drop velocity measurement

    SciTech Connect

    Fobel, Ryan; Donnelly Centre for Cellular and Biomolecular Research, 160 College St., Toronto, Ontario M5S 3E1 ; Fobel, Christian; Wheeler, Aaron R.; Donnelly Centre for Cellular and Biomolecular Research, 160 College St., Toronto, Ontario M5S 3E1; Department of Chemistry, University of Toronto, 80 St. George St., Toronto, Ontario M5S 3H6

    2013-05-13

    We introduce DropBot: an open-source instrument for digital microfluidics (http://microfluidics.utoronto.ca/dropbot). DropBot features two key functionalities for digital microfluidics: (1) real-time monitoring of instantaneous drop velocity (which we propose is a proxy for resistive forces), and (2) application of constant electrostatic driving forces through compensation for amplifier-loading and device capacitance. We anticipate that this system will enhance insight into failure modes and lead to new strategies for improved device reliability, and will be useful for the growing number of users who are adopting digital microfluidics for automated, miniaturized laboratory operation.

  14. DropBot: An open-source digital microfluidic control system with precise control of electrostatic driving force and instantaneous drop velocity measurement

    NASA Astrophysics Data System (ADS)

    Fobel, Ryan; Fobel, Christian; Wheeler, Aaron R.

    2013-05-01

    We introduce DropBot: an open-source instrument for digital microfluidics (http://microfluidics.utoronto.ca/dropbot). DropBot features two key functionalities for digital microfluidics: (1) real-time monitoring of instantaneous drop velocity (which we propose is a proxy for resistive forces), and (2) application of constant electrostatic driving forces through compensation for amplifier-loading and device capacitance. We anticipate that this system will enhance insight into failure modes and lead to new strategies for improved device reliability, and will be useful for the growing number of users who are adopting digital microfluidics for automated, miniaturized laboratory operation.

  15. Efficient dye regeneration at low driving force achieved in triphenylamine dye LEG4 and TEMPO redox mediator based dye-sensitized solar cells.

    PubMed

    Yang, Wenxing; Vlachopoulos, Nick; Hao, Yan; Hagfeldt, Anders; Boschloo, Gerrit

    2015-06-28

    Minimizing the driving force required for the regeneration of oxidized dyes using redox mediators in an electrolyte is essential to further improve the open-circuit voltage and efficiency of dye-sensitized solar cells (DSSCs). Appropriate combinations of redox mediators and dye molecules should be explored to achieve this goal. Herein, we present a triphenylamine dye, LEG4, in combination with a TEMPO-based electrolyte in acetonitrile (E(0) = 0.89 V vs. NHE), reaching an efficiency of up to 5.4% under one sun illumination and 40% performance improvement compared to the previously and widely used indoline dye D149. The origin of this improvement was found to be the increased dye regeneration efficiency of LEG4 using the TEMPO redox mediator, which regenerated more than 80% of the oxidized dye with a driving force of only ∼0.2 eV. Detailed mechanistic studies further revealed that in addition to electron recombination to oxidized dyes, recombination of electrons from the conducting substrate and the mesoporous TiO2 film to the TEMPO(+) redox species in the electrolyte accounts for the reduced short circuit current, compared to the state-of-the-art cobalt tris(bipyridine) electrolyte system. The diffusion length of the TEMPO-electrolyte based DSSCs was determined to be ∼0.5 μm, which is smaller than the ∼2.8 μm found for cobalt-electrolyte based DSSCs. These results show the advantages of using LEG4 as a sensitizer, compared to previously record indoline dyes, in combination with a TEMPO-based electrolyte. The low driving force for efficient dye regeneration presented by these results shows the potential to further improve the power conversion efficiency (PCE) of DSSCs by utilizing redox couples and dyes with a minimal need of driving force for high regeneration yields. PMID:26016854

  16. Deciphering the driving forces of short-term erosion in glacially impacted landscapes, an example from the Western Alps

    NASA Astrophysics Data System (ADS)

    Glotzbach, Christoph; van der Beek, Peter; Carcaillet, Julien; Delunel, Romain

    2013-04-01

    Tectonic uplift is the main driver of long-term erosion, but climate changes can markedly affect the link between tectonics and erosion, causing transient variations in short-term erosion rate. Here we study the driving forces of short-term erosion rates in the French Western Alps as estimated from in-situ produced cosmogenic 10Be and detrital apatite fission-track thermochronology analysis of stream sediments. Short-term erosion rates from 10Be analyses vary between ~0.27 and ~1.33 mm/yr, similar to rates measured in adjacent areas of the Alps. Part of the data scales positively with elevation, while the full dataset shows a significant positive correlation with steepness index of streams and normalized geophysical relief. Mean long-term exhumation and short-term erosion rates are comparable in areas that are exhuming rapidly (>0.4 km/Myr), but short-term rates are on average two-three (and up to six) times higher than long-term rates in areas where the latter are slow (<0.4 km/Myr). These findings are supported by detrital apatite fission-track age distributions that appear to require similar variations in erosion rates. Major glaciations strongly impacted the external part of the Alps, increasing both long-term exhumation rates as well as relief (e.g. Glotzbach et al. 2011; Häuselmann et al. 2007; Valla et al.). Based on our data, it seems that glacial impact in the more slowly eroding internal part is mainly restricted to relief, which is reflected in high transient short-term erosion rates. The data further reveal that normalized steepness index and ridgeline geophysical relief are well correlated with (and could be used as proxies for) short-term erosion, in contrast to slope, corroborating studies in purely fluvial landscapes. Our study demonstrates that climate change, e.g. through occurrence of major glaciations, can markedly perturb landscapes short-term erosion patterns in regions of tectonically controlled long-term exhumation. Glotzbach C., P.A. van

  17. [Spatio-temporal change of sand-fixing function and its driving forces in desertification control ecological function area of Hunshandake, China].

    PubMed

    Shen, Lu; Tian, Mei-rong; Gao, Ji-xi; Qian, Jin-ping

    2016-01-01

    Soil erosion is an important ecological and environmental problem in Hunshandake Desert, and the sand-fixing function determines the degree of ecological security in the entire region. In order to clarify the situation of windbreak and sand fixation in Hunshandake area, and to guide the prevention and treatment of desertification on regional scale, based on the meteorological and remote sensing data, this paper quantitatively analyzed the temporal and spatial pattern of windbreak and sand fixation ability between 2000-2010 by the revised wind erosion equation (RWEQ) model, meanwhile, the driving forces for each county ( or banner) in the functional zone were analyzed with the method of principal component analysis. The results showed that there was a fluctuation of the sand fixing capacity in Hunshandake over time, generally rendering a decline trend. The coniferous forest and grassland had strong windbreak and sand fixation capacity in unit area among the various land categories. In terms of spatial distribution, the windbreak and sand fixation function in western and southeastern region was weak and needed to be strengthened with ecological restoration efforts. Through the study of the social driving forces of each administrative region in the function zone, there were 3 main social driving forces of soil erosion in the administrative functions: the intensity of input-output, the level of economic development and the level of agriculture-husbandry development. PMID:27228595

  18. Polarization-dependent force driving the Eg mode in bismuth under optical excitation: comparison of first-principles theory with ultra-fast x-ray experiments

    NASA Astrophysics Data System (ADS)

    Fahy, Stephen; Murray, Eamonn

    2015-03-01

    Using first principles electronic structure methods, we calculate the induced force on the Eg (zone centre transverse optical) phonon mode in bismuth immediately after absorption of a ultrafast pulse of polarized light. To compare the results with recent ultra-fast, time-resolved x-ray diffraction experiments, we include the decay of the force due to carrier scattering, as measured in optical Raman scattering experiments, and simulate the optical absorption process, depth-dependent atomic driving forces, and x-ray diffraction in the experimental geometry. We find excellent agreement between the theoretical predictions and the observed oscillations of the x-ray diffraction signal, indicating that first-principles theory of optical absorption is well suited to the calculation of initial atomic driving forces in photo-excited materials following ultrafast excitation. This work is supported by Science Foundation Ireland (Grant No. 12/IA/1601) and EU Commission under the Marie Curie Incoming International Fellowships (Grant No. PIIF-GA-2012-329695).

  19. The Scrunchworm Hypothesis: Transitions Between A-DNA and B-DNA Provide the Driving Force for Genome Packaging in Double-Stranded DNA Bacteriophages

    PubMed Central

    Harvey, Stephen C.

    2015-01-01

    Double-stranded DNA bacteriophages have motors that drive the genome into preformed capsids, using the energy releas ed by hydrolysis of ATP to overcome the forces opposing DNA packaging. Viral packaging motors are the strongest of all biological motors, but it is not known how they generate these forces. Several models for the process of mechanochemical force generation have been put forward, but there is no consensus on which, if any, of these is correct. All the existing models assume that protein-generated forces drive the DNA forward. The scrunchworm hypothesis proposes that the DNA molecule is the active force-generating core of the motor, not simply a substrate on which the motor operates. The protein components of the motor dehydrate a section of the DNA, converting it from the B form to the A form and shortening it by about 23%. The proteins then rehydrate the DNA, which converts back to the B form. Other regions of the motor grip and release the DNA to capture the shortening-lengthening motions of the B→A→B cycle (“scrunching”), so that DNA is pulled into the motor and pushed forward into the capsid. This DNA-centric mechanism provides a quantitative physical explanation for the magnitude of the forces generated by viral packaging motors. It also provides a simple explanation for the fact that each of the steps in the burst cycle advances the DNA by 2.5 base pairs. The scrunchworm hypothesis is consistent with a large body of published data, and it makes four experimentally testable predictions. PMID:25486612

  20. The Driving Forces of the Large-Scale Deformation in the India-Eurasia Collision Region: Joint Modeling of Lithosphere and Mantle Dynamics

    NASA Astrophysics Data System (ADS)

    Wang, X.; Holt, W. E.; Ghosh, A.

    2014-12-01

    The origin of the large-scale deformation of the India-Eurasia collision zone has been pursued for more than 4 decades. However, the driving forces for the largest area of continental deformation zone on earth have not been entirely resolved; the source of such driving forces remains enigmatic. One reason could be that the driving forces have to be sufficiently large to overcome the resistance of the Tibetan Plateau, created by excess gravitational potential energy (GPE) over a long time span. Another reason is that seismic experiments carried out in the Tibetan Plateau, due to the harsh natural conditions, are fewer, making it challenging to resolve high-resolution seismic structure beneath Tibet. We address this issue of driving forces in this deformation zone by quantifying the primary contributions to the lithospheric stress field. We take into account effects of topography and shallow lithosphere structure, as well as tractions originating from deeper mantle convection, in order to calculate model estimates of the total lithosphere stresses. We evaluate recent published global seismic tomographic models (P-wave, S-wave, and geodynamic models) and select a tomographic model which, when used in the semi-analytical mantle circulation model HC (Hager and O'Connell, 1981; Milner et al., 2009), provides a best fit to observations of geoid, surface motions, strain rates, and stress orientations. We use the joint modeling of lithosphere and mantle dynamics approach of Ghosh and Holt (2012) to compute the full lithosphere stresses, except that we use HC for the circulation model, which can only handle radial viscosity variations. After using the selected seismic tomographic model of SAW642AN (Panning and Romanowicz, 2006) to compute the global lithosphere stresses, we refine the calculated stresses in the India-Eurasia collision zone. Our results show that both the driving stresses from mantle convection and GPE differences contribute to the deviatoric stress field in

  1. Using geoinformatics and cultural anthropology to identify links between land change, driving forces and actors in the Okavango catchment

    NASA Astrophysics Data System (ADS)

    Röder, Achim; Stellmes, Marion; Pröpper, Michael; Schneibel, Anne

    2015-04-01

    intensive uses, although the same processes are likely to occur in parts of the Okavango region in the future. Literature: Banwart, S. (2011). "Save our soils." Nature 474: 151-152. Bürgi, M., A. M. Hersperger, et al. (2004). "Driving forces of landscape change - current and new directions." Landscape Ecology 19: 857-868. Butchart, S. H. M., M. Walpole, et al. (2010). "Global Biodiversity: Indicators of Recent Declines." Science 328(5982): 1164-1168. Ellis, E. C. and N. Ramankutty (2008). "Putting people in the map: anthropogenic biomes of the world." Frontiers in Ecology and the Environment 6(8): 439-447. Foley, J. A., R. Defries, et al. (2005). "Global consequences of land use." Science 309(5734): 570-574. Geist, H. J. and E. F. Lambin (2002). "Proximate causes and underlying driving forces of tropical deforestation." BioScience 52(2): 143-150. Haub, C. (2012) World Population Data Sheet. World Population Hein, L., K. van Koppen, et al. (2006). "Spatial scales, stakeholders and the valuation of ecosystem services." Ecological Economics 57: 209-228. Hersperger, A. M., M.-P. Gennaio, et al. (2010). "Linking land change with driving forces and actors: four conceptual models." Ecology and Society 15(4): 1-17. Huang, C., L. S. Davis, et al. (2002). "An assessment of support vector machines for land cover classification." International Journal of Remote Sensing 23(4): 725-749. IPCC (2013). Climate Change 2013: The Physical Science Basis. Contribution of Working Group I to the Fifth Assessment Report of the Intergovernmental Panel on Climate Change. T. F. Stocker, G. Qin, G.-K. Plattneret al. Cambridge, Cambridge University Press. Jönsson, P. and L. Eklundh (2004). "TIMESAT - a program for analysing time-series of satellite sensor data." Computers and Geosciences 30(833-845). Kowalski, B., N. Azebaze, et al. (2013). "Mashare - The People." Biodiversity & Ecology 5: 121-128. Lal, R. (2013). "Climate-strategic agriculture and the water-soil-waste nexus." Journal of Plant

  2. The Cardiomyopathy Lamin A/C D192G Mutation Disrupts Whole-Cell Biomechanics in Cardiomyocytes as Measured by Atomic Force Microscopy Loading-Unloading Curve Analysis

    PubMed Central

    Lanzicher, Thomas; Martinelli, Valentina; Puzzi, Luca; Del Favero, Giorgia; Codan, Barbara; Long, Carlin S.; Mestroni, Luisa; Taylor, Matthew R. G.; Sbaizero, Orfeo

    2015-01-01

    Atomic force microscopy (AFM) cell loading/unloading curves were used to provide comprehensive insights into biomechanical behavior of cardiomyocytes carrying the lamin A/C (LMNA) D192G mutation known to cause defective nuclear wall, myopathy and severe cardiomyopathy. Our results suggested that the LMNA D192G mutation increased maximum nuclear deformation load, nuclear stiffness and fragility as compared to controls. Furthermore, there seems to be a connection between this lamin nuclear mutation and cell adhesion behavior since LMNA D192G cardiomyocytes displayed loss of AFM probe-to-cell membrane adhesion. We believe that this loss of adhesion involves the cytoskeletal architecture since our microscopic analyses highlighted that mutant LMNA may also lead to a morphological alteration in the cytoskeleton. Furthermore, chemical disruption of the actin cytoskeleton by cytochalasin D in control cardiomyocytes mirrored the alterations in the mechanical properties seen in mutant cells, suggesting a defect in the connection between the nucleoskeleton, cytoskeleton and cell adhesion molecules in cells expressing the mutant protein. These data add to our understanding of potential mechanisms responsible for this fatal cardiomyopathy, and show that the biomechanical effects of mutant lamin extend beyond nuclear mechanics to include interference of whole-cell biomechanical properties. PMID:26323789

  3. AC magnetohydrodynamic microfluidic switch

    SciTech Connect

    Lemoff, A V; Lee, A P

    2000-03-02

    A microfluidic switch has been demonstrated using an AC Magnetohydrodynamic (MHD) pumping mechanism in which the Lorentz force is used to pump an electrolytic solution. By integrating two AC MHD pumps into different arms of a Y-shaped fluidic circuit, flow can be switched between the two arms. This type of switch can be used to produce complex fluidic routing, which may have multiple applications in {micro}TAS.

  4. Driving Forces of Dynamic Changes in Soil Erosion in the Dahei Mountain Ecological Restoration Area of Northern China Based on GIS and RS

    PubMed Central

    Li, Xiao; Niu, Xiang; Wang, Bing; Gao, Peng; Liu, Yu

    2016-01-01

    Dynamic change in soil erosion is an important focus of regional ecological restoration research. Here, the dynamic changes of soil erosion and its driving forces in the Dahei Mountain ecological restoration area of northern China were analyzed by LANDSAT TM remote sensing captured via geographic information system (GIS) technologies during three typical periods in 2004, 2008 and 2013. The results showed the following: (1) a decrease in intensive erosion and moderate erosion areas, as well as an increase in light erosion areas, was observed during two periods: one from 2004 to 2008 and the other from 2008 to 2013. (2) Between 2004 and 2008, the variation in the range of slight erosion was the largest (24.28%), followed by light erosion and intensive erosion; between 2008 and 2013, the variation in the range of intensive erosion area was the largest (9.89%), followed by slight erosion and moderate erosion. (3) Socioeconomic impact, accompanied by natural environmental factors, was the main driving force underlying the change in soil erosion within the ecological restoration area. In particular, the socioeconomic factors of per capita forest area and land reclamation rate, as well as the natural environmental factor of terrain slope, significantly influenced soil erosion changes within the ecological restoration area. PMID:26981637

  5. Multiple G-quartet structures in pre-edited mRNAs suggest evolutionary driving force for RNA editing in trypanosomes.

    PubMed

    Leeder, W-Matthias; Hummel, Niklas F C; Göringer, H Ulrich

    2016-01-01

    Mitochondrial transcript maturation in African trypanosomes requires a U-nucleotide specific RNA editing reaction. In its most extreme form hundreds of U's are inserted into and deleted from primary transcripts to generate functional mRNAs. Unfortunately, both origin and biological role of the process have remained enigmatic. Here we report a so far unrecognized structural feature of pre-edited mRNAs. We demonstrate that the cryptic pre-mRNAs contain numerous clustered G-nt, which fold into G-quadruplex (GQ) structures. We identified 27 GQ's in the different pre-mRNAs and demonstrate a positive correlation between the steady state abundance of guide (g)RNAs and the sequence position of GQ-elements. We postulate that the driving force for selecting G-rich sequences lies in the formation of DNA/RNA hybrid G-quadruplex (HQ) structures between the pre-edited transcripts and the non-template strands of mitochondrial DNA. HQ's are transcription termination/replication initiation sites and thus guarantee an unperturbed replication of the mt-genome. This is of special importance in the insect-stage of the parasite. In the transcription-on state, the identified GQ's require editing as a GQ-resolving activity indicating a link between replication, transcription and RNA editing. We propose that the different processes have coevolved and suggest the parasite life-cycle and the single mitochondrion as evolutionary driving forces. PMID:27436151

  6. Driving force for {gamma} {yields} {var{underscore}epsilon} martensitic transformation and stacking fault energy of {gamma} in Fe-Mn binary system

    SciTech Connect

    Lee, Y.K.; Choi, C.S.

    2000-02-01

    A regular solution model for the difference of the chemical free energy between {gamma} and {var{underscore}epsilon} phases during {gamma} {yields} {var{underscore}epsilon} martensitic transformation in the Fe-Mn binary system has been reexamined and partly modified based on many articles concerning the M{sub s} and A{sub s} temperatures of Fe-Mn alloys. Using the regular solution model, the measured M{sub s} temperatures, and a thermodynamic model for the stacking fault energy (SFE) of austenite ({gamma}), the driving force for {gamma} {yields} {epsilon} martensitic transformation, and the SFE of {gamma} have been calculated. The driving force for {gamma} {yields} {epsilon} martensitic transformation increases linearly from {minus}68 to {minus}120 J/mole with increasing Mn content from 16 to 24 wt pct. The SFE of {gamma} decreases to approximately 13 at. pct Mn and then increases with increasing Mn content, which is in better agreement with Schumann's result rather than Volosevich et al.'s result.

  7. Multiple Infections with Cardinium and Two Strains of Wolbachia in The Spider Mite Tetranychus phaselus Ehara: Revealing New Forces Driving the Spread of Wolbachia

    PubMed Central

    Zhao, Dong-Xiao; Chen, Da-Song; Ge, Cheng; Gotoh, Tetsuo; Hong, Xiao-Yue

    2013-01-01

    Cytoplasmic incompatibility (CI) has been proposed as a major mechanism by which certain strains of Wolbachia to invade and persist in host populations. However, mechanisms that underlie the invasion and persistence of non-CI strains are less well understood. Here, we established a spider mite Tetranychus phaselus population multiply infected by Cardinium as well as two distinct lineages of Wolbachia, designated wCon and wOri, to study the forces driving the spread of the non-CI strain of Wolbachia wOri. Interestingly, we found that wOri provided a longevity advantage to its female hosts under ideal conditions, making wOri stay longer in this population, and then being transmitted to more offspring. Furthermore, the lifespan of uninfected females was reduced when mated with multiple-infected males. As a result, the uninfected population is attenuated by the multiple-infected males. Thus, we infer that the host age effects of multiple infection may represent sufficient forces driving the spread of wOri through the host population. PMID:23355904

  8. Driving Forces of Dynamic Changes in Soil Erosion in the Dahei Mountain Ecological Restoration Area of Northern China Based on GIS and RS.

    PubMed

    Li, Xiao; Niu, Xiang; Wang, Bing; Gao, Peng; Liu, Yu

    2016-01-01

    Dynamic change in soil erosion is an important focus of regional ecological restoration research. Here, the dynamic changes of soil erosion and its driving forces in the Dahei Mountain ecological restoration area of northern China were analyzed by LANDSAT TM remote sensing captured via geographic information system (GIS) technologies during three typical periods in 2004, 2008 and 2013. The results showed the following: (1) a decrease in intensive erosion and moderate erosion areas, as well as an increase in light erosion areas, was observed during two periods: one from 2004 to 2008 and the other from 2008 to 2013. (2) Between 2004 and 2008, the variation in the range of slight erosion was the largest (24.28%), followed by light erosion and intensive erosion; between 2008 and 2013, the variation in the range of intensive erosion area was the largest (9.89%), followed by slight erosion and moderate erosion. (3) Socioeconomic impact, accompanied by natural environmental factors, was the main driving force underlying the change in soil erosion within the ecological restoration area. In particular, the socioeconomic factors of per capita forest area and land reclamation rate, as well as the natural environmental factor of terrain slope, significantly influenced soil erosion changes within the ecological restoration area. PMID:26981637

  9. Multiple G-quartet structures in pre-edited mRNAs suggest evolutionary driving force for RNA editing in trypanosomes

    PubMed Central

    Leeder, W.-Matthias; Hummel, Niklas F. C.; Göringer, H. Ulrich

    2016-01-01

    Mitochondrial transcript maturation in African trypanosomes requires a U-nucleotide specific RNA editing reaction. In its most extreme form hundreds of U’s are inserted into and deleted from primary transcripts to generate functional mRNAs. Unfortunately, both origin and biological role of the process have remained enigmatic. Here we report a so far unrecognized structural feature of pre-edited mRNAs. We demonstrate that the cryptic pre-mRNAs contain numerous clustered G-nt, which fold into G-quadruplex (GQ) structures. We identified 27 GQ’s in the different pre-mRNAs and demonstrate a positive correlation between the steady state abundance of guide (g)RNAs and the sequence position of GQ-elements. We postulate that the driving force for selecting G-rich sequences lies in the formation of DNA/RNA hybrid G-quadruplex (HQ) structures between the pre-edited transcripts and the non-template strands of mitochondrial DNA. HQ’s are transcription termination/replication initiation sites and thus guarantee an unperturbed replication of the mt-genome. This is of special importance in the insect-stage of the parasite. In the transcription-on state, the identified GQ’s require editing as a GQ-resolving activity indicating a link between replication, transcription and RNA editing. We propose that the different processes have coevolved and suggest the parasite life-cycle and the single mitochondrion as evolutionary driving forces. PMID:27436151

  10. A piezo motor based on a new principle with high output force, rigidity and integrity: the Tuna Drive.

    PubMed

    Liu, Xiaolong; Lu, Qingyou

    2012-11-01

    We present a linear piezoelectric motor as simple as one piezoelectric scanner tube (PST) spring-clamping a central shaft at both ends with roughly equal clamping forces. The clamping points are aligned with ±X electrodes at one end and ±Y electrodes at the other end. Thus, the ±X (or ±Y) push-pull motions of the PST can cause the push-pull motions of the clamping points on the shaft (called push-pull rubbing), which reduces the total dynamic friction force at one (or the other) end of the PST. This new piezo motor advances one step by fast push-pull rubbing at one end while slowly retracting the PST followed by fast push-pull rubbing at the other end while slowly elongating the PST. Apart from the obvious advantages of simplicity, rigidity, integrity, etc., we will also show that this motor can produce a large output force, which we believe is because of the huge drop of the clamping friction force when the push-pull rubbing occurs. PMID:23206102

  11. A piezo motor based on a new principle with high output force, rigidity and integrity: The Tuna Drive

    NASA Astrophysics Data System (ADS)

    Liu, Xiaolong; Lu, Qingyou

    2012-11-01

    We present a linear piezoelectric motor as simple as one piezoelectric scanner tube (PST) spring-clamping a central shaft at both ends with roughly equal clamping forces. The clamping points are aligned with ±X electrodes at one end and ±Y electrodes at the other end. Thus, the ±X (or ±Y) push-pull motions of the PST can cause the push-pull motions of the clamping points on the shaft (called push-pull rubbing), which reduces the total dynamic friction force at one (or the other) end of the PST. This new piezo motor advances one step by fast push-pull rubbing at one end while slowly retracting the PST followed by fast push-pull rubbing at the other end while slowly elongating the PST. Apart from the obvious advantages of simplicity, rigidity, integrity, etc., we will also show that this motor can produce a large output force, which we believe is because of the huge drop of the clamping friction force when the push-pull rubbing occurs.

  12. Light-induced hydrogen bonding pattern and driving force of electron transfer in AppA BLUF domain photoreceptor.

    PubMed

    Ishikita, Hiroshi

    2008-11-01

    The AppA BLUF (blue light sensing using FAD) domain from Rhodobacter sphaeroides serves as a blue light-sensing photoreceptor. The charge separation process between Tyr-21 and flavin plays an important role in the light signaling state by transforming the dark state conformation to the light state one. By solving the linearized Poisson-Boltzmann equation, I calculated E(m) for Tyr-21, flavin, and redox-active Trp-104 and revealed the electron transfer (ET) driving energy. Rotation of the Gln-63 side chain that converts protein conformation from the dark state to the light state is responsible for the decrease of 150 mV in E(m) for Tyr-21, leading to the significantly larger ET driving energy in the light state conformation. The pK(a) values of protonation for flavin anions are essentially the same in both dark and light state crystal structures. In contrast to the ET via Tyr-21, formation of the W state results in generation of only the dark state conformation (even if the initial conformation is in the light state); this could explain why Trp-104-mediated ET deactivates the light-sensing yield and why the activity of W104A mutant is similar to that of the light-adapted native BLUF. PMID:18647748

  13. The land use change characteristics and its driving force analysis of Shiyang river basin in northwest China

    NASA Astrophysics Data System (ADS)

    Han, Tao; Xie, Yaowen; Jiang, Youyan

    2015-12-01

    In the paper, the use of 1994 and 2005 Landsat TM data monitors the land use and changes of the Shiyang river basin with remote sensing classification comparison under the support of GIS. The result shows that from 1994 to 2005, the area of farmland and settlement land increased greatly and that of grass and forest reduces obviously in this basin; Minqin which is in the lower reaches of Shiyang river basin has a serious desertification with low grass coverage degradation into desert. With a comprehensive analysis about the driving factors of nature and human, population pressure and irrational use of water resource are the key factors of the Land use change and between the natural factor and human factor, human acts leading role.

  14. The endothermic ATP hydrolysis and crossbridge attachment steps drive the increase of force with temperature in isometric and shortening muscle.

    PubMed

    Offer, Gerald; Ranatunga, K W

    2015-04-15

    The isometric tetanic tension of skeletal muscle increases with temperature because attached crossbridge states bearing a relatively low force convert to those bearing a higher force. It was previously proposed that the tension-generating step(s) in the crossbridge cycle was highly endothermic and was therefore itself directly targeted by changes in temperature. However, this did not explain why a rapid rise in temperature (a temperature jump) caused a much slower rate of rise of tension than a rapid length step. This led to suggestions that the step targeted by a temperature rise is not the tension-generating step but is an extra step in the attached pathway of the crossbridge cycle, perhaps located on a parallel pathway. This enigma has been a major obstacle to a full understanding of the operation of the crossbridge cycle. We have now used a previously developed mechano-kinetic model of the crossbridge cycle in frog muscle to simulate the temperature dependence of isometric tension and shortening velocity. We allowed all five steps in the cycle to be temperature-sensitive. Models with different starting combinations of enthalpy changes and activation enthalpies for the five steps were refined by downhill simplex runs and scored by their ability to fit experimental data on the temperature dependence of isometric tension and the relationship between force and shortening velocity in frog muscle. We conclude that the first tension-generating step may be weakly endothermic and that the rise of tension with temperature is largely driven by the preceding two strongly endothermic steps of ATP hydrolysis and attachment of M.ADP.Pi to actin. The refined model gave a reasonable fit to the available experimental data and after a temperature jump the overall rate of tension rise was much slower than after a length step as observed experimentally. The findings aid our understanding of the crossbridge cycle by showing that it may not be necessary to include an additional

  15. The endothermic ATP hydrolysis and crossbridge attachment steps drive the increase of force with temperature in isometric and shortening muscle

    PubMed Central

    Offer, Gerald; Ranatunga, K W

    2015-01-01

    The isometric tetanic tension of skeletal muscle increases with temperature because attached crossbridge states bearing a relatively low force convert to those bearing a higher force. It was previously proposed that the tension-generating step(s) in the crossbridge cycle was highly endothermic and was therefore itself directly targeted by changes in temperature. However, this did not explain why a rapid rise in temperature (a temperature jump) caused a much slower rate of rise of tension than a rapid length step. This led to suggestions that the step targeted by a temperature rise is not the tension-generating step but is an extra step in the attached pathway of the crossbridge cycle, perhaps located on a parallel pathway. This enigma has been a major obstacle to a full understanding of the operation of the crossbridge cycle. We have now used a previously developed mechano-kinetic model of the crossbridge cycle in frog muscle to simulate the temperature dependence of isometric tension and shortening velocity. We allowed all five steps in the cycle to be temperature-sensitive. Models with different starting combinations of enthalpy changes and activation enthalpies for the five steps were refined by downhill simplex runs and scored by their ability to fit experimental data on the temperature dependence of isometric tension and the relationship between force and shortening velocity in frog muscle. We conclude that the first tension-generating step may be weakly endothermic and that the rise of tension with temperature is largely driven by the preceding two strongly endothermic steps of ATP hydrolysis and attachment of M.ADP.Pi to actin. The refined model gave a reasonable fit to the available experimental data and after a temperature jump the overall rate of tension rise was much slower than after a length step as observed experimentally. The findings aid our understanding of the crossbridge cycle by showing that it may not be necessary to include an additional

  16. Selective copper diffusion into quartz-hosted vapor inclusions: Evidence from other host minerals, driving forces, and consequences for Cu-Au ore formation

    NASA Astrophysics Data System (ADS)

    Seo, Jung Hun; Heinrich, Christoph A.

    2013-07-01

    Recent experimental studies have raised concerns that Cu concentrations in quartz-hosted fluid inclusions from magmatic-hydrothermal ore deposits do not represent pristine concentrations in the trapped fluids, but are modified by post-entrapment diffusional exchange through the host quartz. New microanalyses of fluid inclusions hosted in topaz show significantly lower Cu concentrations in vapor inclusions, compared to otherwise identical inclusions hosted by coexisting quartz, whereas coeval brine (hypersaline liquid) inclusions are very similar independent of host mineral in one sample. Sulfur is present as a major component in all vapor inclusions, as in most porphyry-related vapor inclusions, and Cu never exceeds S, but commonly matches the S content at a molar ratio of Cu:S ⩽ 2 in vapor inclusions hosted by quartz. Univalent ions with a radius smaller than ˜1 Å are known to diffuse rapidly through the channels of the quartz structure, parallel to its crystallographic c axis. Since only Cu concentrations differ between topaz- and quartz-hosted inclusions, we hypothesize that Cu+ and H+ re-equilibrate by diffusional ion exchange through these channels, while all other element concentrations remain essentially unchanged. A thermodynamic model considering charge-balanced Cu+H+ exchange and diffusive H2 re-equilibration of an initially Cu-poor but S-rich vapor inclusion with a typical rock-buffered fluid environment outside the host crystal demonstrates a strong chemical driving force for Cu+ to migrate from the surrounding rock into the fluid inclusion during cooling of the system. The driving force for Cu diffusion, against the gradient in total Cu concentration, is the abundant H+ liberated inside the inclusion by dissociation of HCl and particularly by the precipitation of CuFeS2 by reaction with the initially trapped H2S and/or SO2. Gold is not only a much larger ion, but is subject to an opposing driving force, suggesting that high concentrations of this

  17. Up-regulation of Rho/ROCK signaling in sarcoma cells drives invasion and increased generation of protrusive forces.

    PubMed

    Rösel, Daniel; Brábek, Jan; Tolde, Ondrej; Mierke, Claudia T; Zitterbart, Daniel P; Raupach, Carina; Bicanová, Krisýtyna; Kollmannsberger, Philip; Panková, Daniela; Vesely, Pavel; Folk, Petr; Fabry, Ben

    2008-09-01

    Tumor cell invasion is the most critical step of metastasis. Determination of the mode of invasion within the particular tumor is critical for effective cancer treatment. Protease-independent amoeboid mode of invasion has been described in carcinoma cells and more recently in sarcoma cells on treatment with protease inhibitors. To analyze invasive behavior, we compared highly metastatic sarcoma cells with parental nonmetastatic cells. The metastatic cells exhibited a functional up-regulation of Rho/ROCK signaling and, similarly to carcinoma cells, an amoeboid mode of invasion. Using confocal and traction force microscopy, we showed that an up-regulation of Rho/ROCK signaling leads to increased cytoskeletal dynamics, myosin light chain localization, and increased tractions at the leading edge of the cells and that all of these contributed to increased cell invasiveness in a three-dimensional collagen matrix. We conclude that cells of mesenchymal origin can use the amoeboid nonmesenchymal mode of invasion as their primary invading mechanism and show the dependence of ROCK-mediated amoeboid mode of invasion on the increased capacity of cells to generate force. PMID:18819929

  18. Interactions of aromatic heterocycles with water: the driving force from free-jet rotational spectroscopy and model electrostatic calculations.

    PubMed

    Maris, Assimo; Melandri, Sonia; Miazzi, Marta; Zerbetto, Francesco

    2008-06-23

    The interaction of isolated aromatic nitrogen atoms with water is explored within free jets by using rotational spectroscopy. To the existing data on diazines, we add the case of the 1:1 complex of 1,3,5-triazine and water (where water donates a proton to one of the nitrogen heterocyclic atoms to form a planar adduct). An electrostatic model based on distributed multipoles accurately reproduces the structures of the four azine-water complexes and allows us to understand the forces that stabilize these structures. The applied intermolecular potential allows us to estimate the changes in the thermodynamic functions of the complexes-compared to the separated constituents-and evaluate the temperature at which the complexes are stable under standard conditions. PMID:18470857

  19. Auto Focus and Leveling Control of Large-Scale High-Precision Scan-Stage Using Driving Force and Surface Shape of the Stage

    NASA Astrophysics Data System (ADS)

    Sakata, Koichi; Fujimoto, Hiroshi; Ohtomo, Takeshi; Saiki, Kazuaki

    The large-scale high-precision scan-stage is industrial equipment for microfabrications. The scan-stage needs not only fast and precise positioning but also the attitude control of the stage. The attitude of the stage is disturbed by the stage thrust in scanning. However, the sampling time of output is much longer than the sampling time of control input by DSP because image sensors are employed in the output encoder. It is difficult to reject the disturbances by single-rate feedback system. In this paper, we proposed the attitude control based on PTC (perfect tracking control) using driving force and surface shape of the stage. Finally, simulations and experiments are performed to show the advantages of the proposed control system.

  20. Non-tectonic base level forcings drive widespread transient incision and relief production in the waning Appalachian orogen

    NASA Astrophysics Data System (ADS)

    Prince, P. S.; Richardson, R. P.

    2012-12-01

    The development of knickpoints and steep bedrock gorges within otherwise low-relief landscapes of the Appalachian Highlands has long interested geomorphologists. While large tracts of muted Appalachian topography appear consistent with slow, steady exhumation of a thickened crustal root, active gorge development into lower-relief uplands suggests that Appalachian river systems have been re-energized to incise into bedrock and increase relief. Orogen-scale analysis of incision patterns, fluvial profiles, and surficial deposits indicate that two main sources of non-tectonic base level drop superimposed on the slowly-exhuming Appalachian landscape can explain the Cenozoic relief production observed. Along the Eastern Continental Divide on the southeast margin of the Highlands, repeated capture of headwaters of elevated, landward-draining streams of the Blue Ridge by Atlantic basin streams maintains the oversteepened slopes and bedrock gorges of the Blue Ridge Escarpment zone. Capture events induce a transient erosional response in which rapid knickpoint retreat carves deep gorges into the captured basin, ultimately adjusting topography to match the rest of the Atlantic slope. In the lower reaches of landward Appalachian rivers still following courses to the continental interior, hillslope steepening in the wake of migrating knickpoints is apparent against the backdrop of a comparatively low-relief upland. This landscape suggests that landward base level drop, possibly due to rapid, glacially-forced Plio-Pleistocene drainage rearrangement, has initiated transgressive waves of incision to adjust Highlands topography to the recently-established continental interior drainage pattern. Encroachment of both the post-rift seaward base level and the modern landward base level forces a rapid release of potential energy stored in the elevated Highlands, energizing streams to incise into bedrock without the introduction of new tectonic energy. The southern Appalachian landscape

  1. The effect of electric field geometry on the performance of electromembrane extraction systems: footprints of a third driving force along with migration and diffusion.

    PubMed

    Moazami, Hamid Reza; Hosseiny Davarani, Saied Saeed; Mohammadi, Jamil; Nojavan, Saeed; Abrari, Masoud

    2015-09-01

    The distribution of electric field vectors was first calculated for electromembrane extraction (EME) systems in classical and cylindrical electrode geometries. The results showed that supported liquid membrane (SLM) has a general field amplifying effect due to its lower dielectric constant in comparison with aqueous donor/acceptor solutions. The calculated norms of the electric field vector showed that a DC voltage of 50 V can create huge electric field strengths up to 64 kV m(-1) and 111 kV m(-1) in classical and cylindrical geometries respectively. In both cases, the electric field strength reached its peak value on the inner wall of the SLM. In the case of classical geometry, the field strength was a function of the polar position of the SLM whereas the field strength in cylindrical geometry was angularly uniform. In order to investigate the effect of the electrode geometry on the performance of real EME systems, the analysis was carried out in three different geometries including classical, helical and cylindrical arrangements using naproxen and sodium diclofenac as the model analytes. Despite higher field strength and extended cross sectional area, the helical and cylindrical geometries gave lower recoveries with respect to the classical EME. The observed decline of the signal was proved to be against the relations governing migration and diffusion processes, which means that a third driving force is involved in EME. The third driving force is the interaction between the radially inhomogeneous electric field and the analyte in its neutral form. PMID:26388374

  2. Analysis of Urban-Rural Land-Use Change during 1995-2006 and Its Policy Dimensional Driving Forces in Chongqing, China

    PubMed Central

    Long, Hualou; Wu, Xiuqin; Wang, Wenjie; Dong, Guihua

    2008-01-01

    This paper analyzes the urban-rural land-use change of Chongqing and its policy dimensional driving forces from 1995 to 2006, using high-resolution Landsat TM (Thematic Mapper) data of 1995, 2000 and 2006, and socio-economic data from both research institutes and government departments. The outcomes indicated that urban-rural land-use change in Chongqing can be characterized by two major trends: First, the non-agricultural land increased substantially from 1995 to 2006, thus causing agricultural land especially farmland to decrease continuously. Second, the aggregation index of urban settlements and rural settlements shows that local urban-rural development experienced a process of changing from aggregation (1995-2000) to decentralization (2000-2006). Chongqing is a special area getting immersed in many important policies, which include the establishment of the municipality directly under the Central Government, the building of Three Gorges Dam Project, the Western China Development Program and the Grain-for-Green Programme, and bring about tremendous influences on its land-use change. By analyzing Chongqing's land-use change and its policy driving forces, some implications for its new policy of ‘Urban-rural Integrated Reform’ are obtained. That is more attentions need to be paid to curbing excessive and idle rural housing and consolidating rural construction land, and to laying out a scientific land-use plan for its rural areas taking such rural land-use issues as farmland occupation and rural housing land management into accounts, so as to coordinate and balance the urban-rural development.

  3. Persistent disparities in stratospheric water vapor measurements drive large uncertainties in the radiative forcing by lower stratospheric water vapor

    NASA Astrophysics Data System (ADS)

    Hurst, D. F.; Rosenlof, K. H.; Portmann, R. W.; Voemel, H.; Schiller, C.; Smith, J. B.; Thornberry, T. D.; Rollins, A. W.; Hall, E.; Jordan, A.; Oltmans, S. J.

    2011-12-01

    Lower stratospheric water vapor is a powerful attenuator of outgoing long wave radiation, hence its strong influence on the Earth's radiation budget. The radiative forcing by lower stratospheric water vapor is, however, quite uncertain because of significant disparities in lower stratospheric water vapor measurements by different instruments. Specifically, measurement discrepancies of 0.5 to 2 ppmv H2O (15 to 60%) between several well-established aircraft- and balloon-borne instruments have now persisted for almost two decades. The Mid-latitude Airborne Cirrus Properties Experiment (MACPEX) in April 2011 provided not only a fresh opportunity to reexamine and reevaluate these persistent measurement discrepancies, but also to compare water vapor measurements by additional aircraft-based instrumentation. Here we compare the in situ measurements of lower stratospheric water vapor by five different instruments during MACPEX. Three of these instruments (Harvard water, FISH, and NOAA CIMS) were aboard the NASA WB-57 aircraft, while two (CFH and NOAA FPH) were launched on balloons. Substantial efforts were made to coordinate aircraft and balloon measurements in space and time, such that the aircraft would reach maximum altitude en route to the balloon rendezvous point, then both aircraft and balloon would descend together. Lower stratospheric water vapor measurements during MACPEX generally fall into two groups: CFH, NOAA FPH and FISH are in good agreement, while Harvard water and NOAA CIMS agree with each other but are significantly different than the other group. Differences between the two groups range from 0.5 to 1.0 ppmv (15 to 30%), with Harvard and NOAA CIMS mixing ratios consistently higher. Though these differences seem relatively large, they are smaller than some previously observed differences between the FPH/CFH and Harvard water. For example, Harvard stratospheric water vapor measurements during the 1993 CEPEX and 2006 CR-AVE campaigns were 1.5 and 2 ppmv

  4. Vibrational relaxation as the driving force for wavelength conversion in the peridinin-chlorophyll a-protein.

    PubMed

    Götze, Jan P; Karasulu, Bora; Patil, Mahendra; Thiel, Walter

    2015-12-01

    We present a computationally derived energy transfer model for the peridinin-chlorophyll a-protein (PCP), which invokes vibrational relaxation in the two lowest singlet excited states rather than internal conversion between them. The model allows an understanding of the photoinduced processes without assuming further electronic states or a dependence of the 2Ag state character on the vibrational sub-state. We report molecular dynamics simulations (CHARMM22 force field) and quantum mechanics/molecular mechanics (QM/MM) calculations on PCP. In the latter, the QM region containing a single peridinin (Per) chromophore or a Per-Chl a (chlorophyll a) pair is treated by density functional theory (DFT, CAM-B3LYP) for geometries and by DFT-based multireference configuration interaction (DFT/MRCI) for excitation energies. The calculations show that Per has a bright, green light absorbing 2Ag state, in addition to the blue light absorbing 1Bu state found in other carotenoids. Both states undergo a strong energy lowering upon relaxation, leading to emission in the red, while absorbing in the blue or green. The orientation of their transition dipole moments indicates that both states are capable of excited-state energy transfer to Chl a, without preference for either 1Bu or 2Ag as donor state. We propose that the commonly postulated partial intramolecular charge transfer (ICT) character of a donating Per state can be assigned to the relaxed 1Bu state, which takes on ICT character. By assuming that both 1Bu and 2Ag are able to donate to the Chl a Q band, one can explain why different chlorophyll species in PCP exhibit different acceptor capabilities. PMID:26231454

  5. Common drive unit

    NASA Technical Reports Server (NTRS)

    Ellis, R. C.; Fink, R. A.; Moore, E. A.

    1987-01-01

    The Common Drive Unit (CDU) is a high reliability rotary actuator with many versatile applications in mechanism designs. The CDU incorporates a set of redundant motor-brake assemblies driving a single output shaft through differential. Tachometers provide speed information in the AC version. Operation of both motors, as compared to the operation of one motor, will yield the same output torque with twice the output speed.

  6. Unlocking the biogeochemical black box: What drives microbial response to climate forcing in semi-arid soils?

    NASA Astrophysics Data System (ADS)

    Moravec, B. G.; McLain, J. E.; Lohse, K. A.

    2009-12-01

    Microbial mediated cycling of carbon (C) and nitrogen (N) and their loss from soils are closely linked to soil moisture and temperature. Yet, it is unclear how microbial communities will respond to climatic forcing (namely increased inter-annual precipitation variability and severe drought) and to what extent parent material controls these responses. We used Real Time Polymerase Chain Reaction (RT-PCR) and C utilization assays to determine the relative abundance and diversity of microbial populations during pre-, mid- and post-monsoon time intervals at four sites along a steep elevation gradient (temperature and precipitation range of >10°C and >50 cm, respectively) in the Santa Catalina Mountains, AZ. Contrasting parent materials (schist and granite) were paired at elevations. RT-PCR results showed large increases of bacterial and fungal biomarkers at high elevations with the onset of precipitation (pre- to mid- monsoon conditions) (as much as 824%). In contrast, bacteria biomarkers did not change at low elevation granite site as a result of the onset of precipitation whereas fungal biomarkers increased by 177% at this site. Both bacteria and fungal biomarkers increased substantially at low elevation schist sites with the onset of precipitation. Finally, C utilization assays indicated that high elevation sites had a relatively high diversity of C utilization compared to low elevation soils. We hypothesize that increased bacterial and fungal abundance in low elevation schist-derived soils relative to granite soils after the onset of monsoon rains may be a function of soil texture, with higher clay content in schist soils leading to higher soil moisture availability. Alternatively, differences in microbial responses may be due to higher C availability in schist soils compared to granite soils. Higher C utilization diversity as well as similar bacteria and fungal biomarker responses found at high elevation sites (both granite and schist soils) in response to

  7. Mediterranean coastal dune vegetation: Are disturbance and stress the key selective forces that drive the psammophilous succession?

    NASA Astrophysics Data System (ADS)

    Ciccarelli, Daniela

    2015-11-01

    Plant communities of coastal dunes are distributed along a characteristic sea-inland gradient. Generally, there is a shift from annual and short height species with small leaves in the initial successional stages to perennial tall shrubs with tough leaves in later phases. Assessing the community-weighted mean (CWM) trait values is used in plant ecology to describe ecosystem properties especially during succession. In particular, CSR (Competitive, Stress-tolerant, and Ruderal strategy) classification allows us to explore community functional shifts in terms of disturbance, stress and competition selective forces. The functional basis of the psammophilous succession was studied based on the following questions: (1) Can we circumscribe different functional types among plant species of Mediterranean coastal dunes? (2) How do CWM trait values vary along the environmental sea-inland gradient? (3) What is the relative importance of competition, stress and disturbance in the processes of plant community assembling? (4) Can we postulate that along primary successions there is generally a shift from ruderality to stress-tolerance? An explorative analysis of functional groups was performed by Non-Metric Multidimensional Scaling (NMDS) analysing nine morpho-functional traits measured for 45 taxa from 880 dune plots localised in Tuscany (central Italy, Europe). NMDS ordination showed a scattered distribution of psammophytes that could not be delimited in precise plant functional types. The first NMDS axis has been interpreted as a leaf economics axis because it was correlated to leaf area (LA) and leaf dry matter content (LDMC), while the second one was a plant size axis because of its correlation with canopy height. Along the sea-inland gradient, pioneer plant communities of upper beach were dominated by ruderals (with the lowest values of LDMC and specific leaf area - SLA), well-adapted to the harsh environmental conditions of coastal dunes. More distant from the sea, where

  8. 10-15 years of GST monitoring over mountain permafrost in Switzerland: Indicators for driving forces for permafrost evolution

    NASA Astrophysics Data System (ADS)

    Staub, Benno; Delaloye, Reynald; Hilbich, Christin; Lambiel, Christophe; Nötzli, Jeannette; Völksch, Ingo

    2013-04-01

    Ground Surface Temperatures (GST) are mainly controlled by atmospheric factors and topographical effects and represent an important standard element within the operational permafrost monitoring network PERMOS in Switzerland. Due to its shape, position and extent the Alpine arc is influenced by prevailing winds from several directions provoking a complex and highly variable pattern of precipitation in different regions of Switzerland with a general trend to a more continental climate in some inner-alpine valleys. The lower boundary for the occurrence of mountain permafrost in the Swiss Alps is located at about 2500 m asl., close to the free atmosphere where air temperatures are almost homogenous in all regions, but precipitation usually shows large regional differences regarding timing and quantity depending on the meteorological conditions. At the elevation range of mountain permafrost the ground surface remains snow-free only for about 4-5 months (between June and November) with a high temporal and spatial variability, while over the rest of the year it stays well shielded from the atmosphere (due to the high surface albedo and emissivity and low thermal conductivity of snow). Therefore, the influence of the atmosphere at this boundary layer on the ground thermal regime is well reflected by GST measurements on a very local, site-specific scale. Relative values like GST anomalies can serve as indicators describing processes of energy and heat transfer at the ground surface in a semi-quantitative way. This information is used in a signal-response analysis integrating GST with other permafrost monitoring elements that represent the permafrost response to external effects (e.g. relative changes in borehole temperatures, apparent electrical resistivities or rock glacier creep rates). To identify and quantify the dominant processes and factors controlling the response of Alpine permafrost to external forces, special consideration is devoted to the characteristics of

  9. A thermo-mechanical correlation with driving forces for hcp martensite and twin formations in the Fe–Mn–C system exhibiting multicomposition sets

    SciTech Connect

    Nakano, Jinichiro

    2013-03-15

    Thermodynamic properties of the Fe-Mn-C system were investigated by using an analytical model constructed by a CALPHAD approach. Stacking fault energy (SFE) of the fcc structure with respect to the hcp phase was always constant at T0, independent of composition and temperature when the other related parameters were assumed to be constant. Experimental limits for the thermal hcp formation and the mechanical (deformation-induced) hcp formation were separated by the SFE at T0. The driving force for the fcc to hcp transition, defined as a dimensionless value –dGm/(RT), was determined in the presence of Fe-rich and Mn-rich composition sets in each phase. Carbon tended to partition to the Mn-rich phase rather than to the Fe-rich phase for the studied compositions. The obtained results revealed a thermo-mechanical correlation with empirical yield strength, maximum true stress and maximum true strain. The proportionality between thermodynamics and mechanical properties is discussed.

  10. Mannose-Binding Lectin Inhibits the Motility of Pathogenic Salmonella by Affecting the Driving Forces of Motility and the Chemotactic Response

    PubMed Central

    Nakamura, Shuichi; Islam, Md. Shafiqul; Guo, Yijie; Ihara, Kohei; Tomioka, Rintaro; Masuda, Mizuki; Yoneyama, Hiroshi; Isogai, Emiko

    2016-01-01

    Mannose-binding lectin (MBL) is a key pattern recognition molecule in the lectin pathway of the complement system, an important component of innate immunity. MBL functions as an opsonin which enhances the sequential immune process such as phagocytosis. We here report an inhibitory effect of MBL on the motility of pathogenic bacteria, which occurs by affecting the energy source required for motility and the signaling pathway of chemotaxis. When Salmonella cells were treated with a physiological concentration of MBL, their motile fraction and free-swimming speed decreased. Rotation assays of a single flagellum showed that the flagellar rotation rate was significantly reduced by the addition of MBL. Measurements of the intracellular pH and membrane potential revealed that MBL affected a driving force for the Salmonella flagellum, the electrochemical potential difference of protons. We also found that MBL treatment increased the reversal frequency of Salmonella flagellar rotation, which interfered with the relative positive chemotaxis toward an attractive substrate. We thus propose that the motility inhibition effect of MBL may be secondarily involved in the attack against pathogens, potentially facilitating the primary role of MBL in the complement system. PMID:27104738

  11. An ANCCA/PRO2000-miR-520a-E2F2 regulatory loop as a driving force for the development of hepatocellular carcinoma.

    PubMed

    Huang, J; Yang, J; Lei, Y; Gao, H; Wei, T; Luo, L; Zhang, F; Chen, H; Zeng, Q; Guo, L

    2016-01-01

    Hepatocellular carcinoma (HCC) is one of the most common malignancies in Asia especially in China. We previously identified that ANCCA/PRO2000 as an important proliferation-associated protein predicted poor prognosis of patients with HCC. However, the molecular mechanisms of ANCCA/PRO2000 leading to hepatocarcinogenesis and progression are still obscure. In the present study, we found that ANCCA/PRO2000 overexpression in HCC specimens correlated with aggressive tumor behavior and poor survival. Furthermore, ANCCA/PRO2000 exerts strong oncogenic function in HCC and promotes cell proliferation by regulating E2F2 expression, a critical cell cycle regulator. Notably, miR-520a is an intermediate regulator between ANCCA/PRO2000 and E2F2. Mechanistically, ANCCA/PRO2000 not only interacts with E2F2 but also negatively regulates miR-520a that inhibits E2F2 to cooperatively promote in vitro and in vivo growth of HCC cells. Moreover, we demonstrated that ANCCA/PRO2000 enhances the migratory capacity of HCC cells partially by suppressing ERO1L and G3BP2 expression. Additional research identified that miR-372, as a prognostic factor for HCC, could directly target ANCCA/PRO2000. Our results suggest the ANCCA/PRO2000-miR-520a-E2F2 regulatory loop as a driving force for HCC development and ANCCA/PRO2000 as a potential therapeutic target for HCC. PMID:27239961

  12. Variation in the Chemical Driving Force for Intragranular Nucleation in the Multi-pass Weld Metal of Ti-Containing High-Strength Low-Alloy Steel

    NASA Astrophysics Data System (ADS)

    Kang, Yongjoon; Han, Kyutae; Park, Joo Hyun; Lee, Changhee

    2015-08-01

    The variation of the Mn-depleted zone (MDZ) around the inclusion during multi-pass welding of Ti-containing high-strength low-alloy (HSLA) steel was investigated by taking the changes in the impact toughness and microstructure into account. As-deposited weld metal specimens were prepared by single-pass, bead-in-groove welding, and reheated weld metal specimens were obtained by a thermal simulation technique. Two types of chemical compositions were prepared, mainly by controlling the Ti content in order to form two types of phases at inclusion/matrix interface: spinel and ilmenite. When the reheating thermal cycle is applied to the as-deposited weld metal, the MDZ depth varied depending on the inclusion surface phase; this could be explained by the competition of the homogenization effect and the dissolution effect, which occurred near the inclusion/matrix interface. In order to enhance the chemical driving force for intragranular nucleation in both as-deposited weld metal and reheated weld metal, the formation of ilmenite phase is recommended.

  13. A thermo-mechanical correlation with driving forces for hcp martensite and twin formations in the Fe–Mn–C system exhibiting multicomposition sets

    DOE PAGESBeta

    Nakano, Jinichiro

    2013-03-15

    Thermodynamic properties of the Fe-Mn-C system were investigated by using an analytical model constructed by a CALPHAD approach. Stacking fault energy (SFE) of the fcc structure with respect to the hcp phase was always constant at T0, independent of composition and temperature when the other related parameters were assumed to be constant. Experimental limits for the thermal hcp formation and the mechanical (deformation-induced) hcp formation were separated by the SFE at T0. The driving force for the fcc to hcp transition, defined as a dimensionless value –dGm/(RT), was determined in the presence of Fe-rich and Mn-rich composition sets in eachmore » phase. Carbon tended to partition to the Mn-rich phase rather than to the Fe-rich phase for the studied compositions. The obtained results revealed a thermo-mechanical correlation with empirical yield strength, maximum true stress and maximum true strain. The proportionality between thermodynamics and mechanical properties is discussed.« less

  14. The spatial-temporal patterns and the driving forces of land-use/cover change in the Dongting Lake area of the middle Yangtze River basin

    NASA Astrophysics Data System (ADS)

    Li, Rendong; Liu, Jiyuan; Zhuang, Dafang; Gao, Zhiqiang

    2004-11-01

    Dongting Lake area, located on the southern bank of the middle Yangtze River in central China, is one of the regions experiencing rapid land use change and seriously suffering from flooding disaster in the country. In this paper, a series of land-use coverage was generated through visually interpreting Landsat MSS, TM and ETM images, of 1980, 1990 and 2000 respectively. Then, the spatial-temporal characteristics and the driving forces of the land use changes were analyzed in the study area. The results show that, from 1980 to 2000, the areas of farmland, woodland and non-used land decreased, while those of built-up land, water area and grassland increased. There was a significant shifting from farmland to water or built-up area, and the large-scale reclamation from the lake ever in history has not been found since 1980. The fastest changed area was in Shishou City, Yueyang City and Jinshi City, and the slowest in the eastern and southeastern area. About 49% of the changes were caused by the adjustment of agricultural economic structure, 29.75% by the urbanization and industrialization, and 21.41% by the environmental pressure. The policy, market price and tax on land products also have definitively influences on the land-use changes.

  15. Fixed negative charge and the Donnan effect: a description of the driving forces associated with brain tissue swelling and oedema

    PubMed Central

    Elkin, Benjamin S.; Shaik, Mohammed A.; Morrison, Barclay

    2010-01-01

    Cerebral oedema or brain tissue swelling is a significant complication following traumatic brain injury or stroke that can increase the intracranial pressure (ICP) and impair blood flow. Here, we have identified a potential driver of oedema: the negatively charged molecules fixed within cells. This fixed charge density (FCD), once exposed, could increase ICP through the Donnan effect. We have shown that metabolic processes and membrane integrity are required for concealing this FCD as slices of rat cortex swelled immediately (within 30 min) following dissection if treated with 2 deoxyglucose + cyanide (2DG+CN) or Triton X-100. Slices given ample oxygen and glucose, however, did not swell significantly. We also found that dead brain tissue swells and shrinks in response to changes in ionic strength of the bathing medium, which suggests that the Donnan effect is capable of pressurizing and swelling brain tissue. As predicted, a non-ionic osmolyte, 1,2 propanediol, elicited no volume change at 2000×10−3 osmoles l−1 (Osm). Swelling data were well described by triphasic mixture theory with the calculated reference state FCD similar to that measured with a 1,9 dimethylmethylene blue assay. Taken together, these data suggest that intracellular fixed charges may contribute to the driving forces responsible for brain swelling. PMID:20047940

  16. Driving forces of researchers mobility

    PubMed Central

    Gargiulo, Floriana; Carletti, Timoteo

    2014-01-01

    Starting from the dataset of the publication corpus of the APS during the period 1955–2009, we reconstruct the individual researchers trajectories, namely the list of the consecutive affiliations for each scholar. Crossing this information with different geographic datasets we embed these trajectories in a spatial framework. Using methods from network theory and complex systems analysis we characterise these patterns in terms of topological network properties and we analyse the dependence of an academic path across different dimensions: the distance between two subsequent positions, the relative importance of the institutions (in terms of number of publications) and some socio–cultural traits. We show that distance is not always a good predictor for the next affiliation while other factors like “the previous steps” of the career of the researchers (in particular the first position) or the linguistic and historical similarity between two countries can have an important impact. Finally we show that the dataset exhibit a memory effect, hence the fate of a career strongly depends from the first two affiliations. PMID:24810800

  17. Driving forces of researchers mobility

    NASA Astrophysics Data System (ADS)

    Gargiulo, Floriana; Carletti, Timoteo

    2014-05-01

    Starting from the dataset of the publication corpus of the APS during the period 1955-2009, we reconstruct the individual researchers trajectories, namely the list of the consecutive affiliations for each scholar. Crossing this information with different geographic datasets we embed these trajectories in a spatial framework. Using methods from network theory and complex systems analysis we characterise these patterns in terms of topological network properties and we analyse the dependence of an academic path across different dimensions: the distance between two subsequent positions, the relative importance of the institutions (in terms of number of publications) and some socio-cultural traits. We show that distance is not always a good predictor for the next affiliation while other factors like ``the previous steps'' of the career of the researchers (in particular the first position) or the linguistic and historical similarity between two countries can have an important impact. Finally we show that the dataset exhibit a memory effect, hence the fate of a career strongly depends from the first two affiliations.

  18. Driving forces of researchers mobility.

    PubMed

    Gargiulo, Floriana; Carletti, Timoteo

    2014-01-01

    Starting from the dataset of the publication corpus of the APS during the period 1955-2009, we reconstruct the individual researchers trajectories, namely the list of the consecutive affiliations for each scholar. Crossing this information with different geographic datasets we embed these trajectories in a spatial framework. Using methods from network theory and complex systems analysis we characterise these patterns in terms of topological network properties and we analyse the dependence of an academic path across different dimensions: the distance between two subsequent positions, the relative importance of the institutions (in terms of number of publications) and some socio-cultural traits. We show that distance is not always a good predictor for the next affiliation while other factors like "the previous steps" of the career of the researchers (in particular the first position) or the linguistic and historical similarity between two countries can have an important impact. Finally we show that the dataset exhibit a memory effect, hence the fate of a career strongly depends from the first two affiliations. PMID:24810800

  19. Driving forces push Italian exploration

    SciTech Connect

    Steven, R.R.

    1982-03-01

    The Italian offshore is one of the most active in Europe. Although it cannot be compared with the North Sea in terms of hydrocarbon production or potential, Italy is expending a great deal of effort in order to reduce imported oil and gas from the current level of around 90% of total domestic consumption of 147 million tons of oil equivalent a year. The drilling program, major targets, and development of new oil fields are discussed briefly. (JMT)

  20. Driving forces and risk management

    EPA Science Inventory

    From a public health perspective, food safety is the overall goal and there are two distinct areas where interventions to this end can take place – either pre- or post-harvest. In pre-harvest, water quality management is the focus whereas post-harvest quality management depends ...

  1. A Driving Force in NASCAR

    ERIC Educational Resources Information Center

    Matthews, Frank J.

    2007-01-01

    Minority participation and interest in sports is legendary--depending on what sport you are talking about. Blacks have long been a major factor in the popularity of basketball and football. Tiger Woods' success has contributed to an explosion of interest in golf within the Black community. Arthur Ashe brought tennis into the Black consciousness,…

  2. Comparison of DC and AC Transport in 1.5-7.5 nm Oligophenylene Imine Molecular Wires across Two Junction Platforms: Eutectic Ga-In versus Conducting Probe Atomic Force Microscope Junctions.

    PubMed

    Sangeeth, C S Suchand; Demissie, Abel T; Yuan, Li; Wang, Tao; Frisbie, C Daniel; Nijhuis, Christian A

    2016-06-15

    We have utilized DC and AC transport measurements to measure the resistance and capacitance of thin films of conjugated oligophenyleneimine (OPI) molecules ranging from 1.5 to 7.5 nm in length. These films were synthesized on Au surfaces utilizing the imine condensation chemistry between terephthalaldehyde and 1,4-benzenediamine. Near edge X-ray absorption fine structure (NEXAFS) spectroscopy yielded molecular tilt angles of 33-43°. To probe DC and AC transport, we employed Au-S-OPI//GaOx/EGaIn junctions having contact areas of 9.6 × 10(2) μm(2) (10(9) nm(2)) and compared to previously reported DC results on the same OPI system obtained using Au-S-OPI//Au conducting probe atomic force microscopy (CP-AFM) junctions with 50 nm(2) areas. We found that intensive observables agreed very well across the two junction platforms. Specifically, the EGaIn-based junctions showed: (i) a crossover from tunneling to hopping transport at molecular lengths near 4 nm; (ii) activated transport for wires >4 nm in length with an activation energy of 0.245 ± 0.008 eV for OPI-7; (iii) exponential dependence of conductance with molecular length with a decay constant β = 2.84 ± 0.18 nm(-1) (DC) and 2.92 ± 0.13 nm(-1) (AC) in the tunneling regime, and an apparent β = 1.01 ± 0.08 nm(-1) (DC) and 0.99 ± 0.11 nm(-1) (AC) in the hopping regime; (iv) previously unreported dielectric constant of 4.3 ± 0.2 along the OPI wires. However, the absolute resistances of Au-S-OPI//GaOx/EGaIn junctions were approximately 100 times higher than the corresponding CP-AFM junctions due to differences in metal-molecule contact resistances between the two platforms. PMID:27172452

  3. H2O-rich melt inclusions in fayalitic olivine from Hekla volcano: Implications for phase relationships in silicic systems and driving forces of explosive volcanism on Iceland

    NASA Astrophysics Data System (ADS)

    Portnyagin, Maxim; Hoernle, Kaj; Storm, Sonja; Mironov, Nikita; van den Bogaard, Christel; Botcharnikov, Roman

    2012-12-01

    Silicic Icelandic magmas are widely believed to contain low to moderate H2O content prior to degassing, and that their high explosivity mostly results from the interaction of the magmas with ice or meteoric water. Here we report the compositions of glass inclusions (SiO2=57-72 wt%, K2O=1.3-2.6 wt%) in Fe-rich olivines (Fo2-42) from the largest Holocene eruptions of Hekla volcano (H3 and H4) on Iceland, which preserved quenched melts with very high primary H2O contents (3.3-6.2 wt%). The silicic Hekla melts originate primarily by extensive (˜90%) crystal fractionation of H2O-poor (˜0.6 wt%) basalts and represent an end member in the systematics of terrestrial magmas because they originate at low fO2 (ΔQFM ˜-0.1 to -0.4) and have as high H2O contents as significantly more oxidized island-arc magmas (ΔQFM≥1). This demonstrates that H2O and ΔQFM do not correlate in silicic magmas from different tectonic settings, and that fO2, not H2O content, shows a major difference between silicic ocean-island (e.g., Icelandic) and island-arc magmas. Analysis of available experimental data suggests that high H2O activity and low fO2 expand the field of olivine stability in silicic melts. Low fO2 and low MgO content could also suppress crystallization of amphibole. On the basis of these results we propose that an anhydrous mineral assemblage bearing Fe-rich olivine in evolved volcanic and Skaergaard-type intrusive rocks does not imply low H2O in magmas prior to degassing but, in contrast to the commonly held view, is an indicator of H2O-rich silicic parental magmas crystallized at low fO2. Finally, the high H2O content in magma was a major driving force of the largest explosive eruptions of Hekla volcano and must be at least as important for driving silicic explosive volcanism on Iceland as magma-ice interaction.

  4. Magnetostrictive roller drive motor

    NASA Astrophysics Data System (ADS)

    Vranish, John M.

    1992-01-01

    A magnetostrictive drive motor is disclosed which has a rotary drive shaft in the form of a drum which is encircled by a plurality of substantially equally spaced roller members in the form of two sets of cones which are in contact with the respective cam surfaces on the inside surface of an outer drive ring. The drive ring is attached to sets of opposing pairs of magnetostrictive rods. Each rod in a pair is mutually positioned end to end within respective energizing coils. When one of the coils in an opposing pair is energized, the energized rod expands while the other rod is caused to contract, causing the drive ring to rock, i.e., rotate slightly in either the clockwise or counterclockwise direction, depending upon which rod in a pair is energized. As the drive ring is activated in repetitive cycles in either direction, one set of drive cones attempts to roll up their respective cam surface but are pinned between the drive shaft drum and the drive ring. As the frictional force preventing sliding builds up, the cones become locked, setting up reaction forces including a tangential component which is imparted to the drive shaft drum to provide a source of motor torque. Simultaneously the other set of cones are disengaged from the drive shaft drum. Upon deactivation of the magnetostrictive rod coils, the force on the drive cones is released, causing the system to return to an initial rest position. By repetitively cycling the energization of the magnetostrictive rods, the drive shaft drum indexes in microradian rotational steps.

  5. Driving forces for metamorphic vein filling during bauxite dehydration: insights from Li and Al transfer illustrated by LIBS compositional profiles (Western Alps)

    NASA Astrophysics Data System (ADS)

    Verlaguet, Anne; Brunet, Fabrice; Goffé, Bruno; Menut, Denis; Findling, Nathaniel; Poinssot, Christophe

    2015-04-01

    In subduction zones, the significant amounts of aqueous fluid released in the course of the successive dehydration reactions occurring during prograde metamorphism are expected to strongly influence the rock rheology, as well as kinetics of metamorphic reactions and mass transfer efficiency. Mineralized veins, ubiquitous in metamorphic rocks, can be seen as preserved witnesses of fluid and mass redistribution that partly accommodate the rock deformation (lateral segregation). However, the driving forces and mechanisms of mass transfer towards fluid-filled open spaces remain somewhat unclear. The aim of this study is to investigate the vein-forming processes and the modalities of mass transfer during local fluid-rock interactions, and their links with fluid production and rock deformation, with new insights from Laser Induced Breakdown Spectroscopy (LIBS) profiles. This study focuses on karstic pockets (metre scale) of Triassic metabauxites embedded in thick carbonate units, that have been isolated from large-scale fluid flow during HP-LT Alpine metamorphism (W. Vanoise, French Alps). These rocks display several generations of metamorphic veins containing various Al-bearing minerals, which give particular insights into mass transfer processes. It is proposed that the internally-derived fluid (~13 vol% produced by successive dehydration reactions) has promoted the opening of fluid-filled open spaces (euhedral habits of vein minerals) and served as medium for diffusive mass transfer from rock to vein. Based on mineralogical and textural features, two vein types can be distinguished: (1) some veins are filled with newly formed products of either prograde (chloritoid) or retrograde (chlorite) metamorphic reactions; in this case, fluid-filled open spaces seem to offer energetically favourable nucleation/growth sites; (2) the second vein type is filled with cookeite (Li-Al-rich chlorite) or pyrophyllite, which were present in the host-rock prior to the vein formation. In

  6. Interactions between seasonality and oceanic forcing drive the phytoplankton variability in the tropical-temperate transition zone (~ 30°S) of Eastern Australia

    NASA Astrophysics Data System (ADS)

    Armbrecht, Linda H.; Schaeffer, Amandine; Roughan, Moninya; Armand, Leanne K.

    2015-04-01

    The East Australian Current (EAC) has been shown to be warming rapidly, which is expected to cause latitudinal shifts in phytoplankton abundance, distribution and composition along the east Australian coast. Yet a lack of phytoplankton information exists northward of 34°S. Here, we provide the first detailed taxonomic time-series survey (monthly sampling for about one annual cycle, 2011-2012) in the east Australian tropical-temperate transition zone (~ 30°S, upstream of the EAC separation point at ~ 31-32°S). All phytoplankton (categorised depending on their association with specific water-types) show a seasonal signal with abundance maxima (minima) during summer (winter). This seasonal signal is most pronounced in the seasonal/bloom category and least expressed by deep-water taxa, which prefer cold, saline and dense bottom water independent of the season. Different extents of EAC encroachment onto the continental shelf drive the cross-shelf phytoplankton composition and distribution, such that a weak EAC is associated with phytoplankton community being organised along 'depth' and 'distance from the coast' gradients with high phytoplankton abundances inshore. A strong EAC favours the occurrence of warm-water taxa offshore and an increase in diatom abundance on the mid-shelf (53% shelf width). We conclude that the phytoplankton community in the tropical-temperate transition zone of Eastern Australia is driven by an interaction of intrinsic seasonal cycles and primarily EAC-driven oceanic forcing. Our findings benefit studies located in Western Boundary Current systems worldwide, in which warming and strengthening of these currents are predicted to severely impact phytoplankton dynamics.

  7. The SCOPSCO deep drilling program in ancient Lake Ohrid: Unravelling the driving forces of speciation in Europe's oldest and most biodiverse lake

    NASA Astrophysics Data System (ADS)

    Wilke, Thomas; Wagner, Bernd; Albrecht, Christian; Levkov, Zlatko; Francke, Alexander; Hauffe, Torsten; Cvetkoska, Aleksandra; Jovanovska, Elena; Zhang, Xiaosen; Reed, Jane M.; Wagner-Cremer, Friederike; Stelbrink, Björn; Viehberg, Finn

    2015-04-01

    Ancient Lake Ohrid on the Balkan Peninsula constitutes the oldest and most biodiverse lake in Europe. The processes generating this extraordinary species richness with a high share of endemic taxa, however, are poorly understood. In order to unravel the geological and biological history of the lake and to study, among others, the influence of major geological and environmental events on the evolution of endemic taxa, an international research initiative - the SCOPSCO project - was launched. The project combines sedimentological, tephro-stratigraphical, seismic and paleontological (diatoms, mollusks, ostracods) studies of lake sediment cores with molecular-dating and empirical modelling approaches applied to extant taxa. Preliminary analyses of sediment core and borehole logging data from drill sites with a maximum penetration depth of 569 m below lake floor and an overall recovery of > 95 % indicate that Lake Ohrid is roughly 1.3 to 1.5 My old. Intriguingly, these data fully reinforce the results of molecular clock analyses conducted prior to the drilling operation. Moreover, the combined geological and biological studies suggest that the extraordinary biodiversity in Lake Ohrid is largely driven by 1) the long and continuous existence of the lake, 2) the lack of catastrophic events (e.g., desiccation, full glaciation or salinization) during its lifetime potentially causing massive extinctions, 3) the high buffer capacity of the lake to environmental change and/or the high resilience of its taxa, and 4) distinct turnovers in species composition over time promoting frequency dependent selection. The cumulative effect of these factors, in turn, resulted in overall low extinction rates and continuous speciation and radiation events. These findings not only shed new light on patterns and processes of evolution in Europe's oldest lake, they also show that data from sediment cores can contribute to a better understanding of the driving forces of biotic evolution

  8. Selective transport of amino acids into the gas phase: driving forces for amino acid solubilization in gas-phase reverse micelles.

    PubMed

    Fang, Yigang; Bennett, Andrew; Liu, Jianbo

    2011-01-28

    We report a study on encapsulation of various amino acids into gas-phase sodium bis(2-ethylhexyl) sulfosuccinate (NaAOT) reverse micelles, using electrospray ionization guided-ion-beam tandem mass spectrometry. Collision-induced dissociation of mass-selected reverse micellar ions with Xe was performed to probe structures of gas-phase micellar assemblies, identify solute-surfactant interactions, and determine preferential incorporation sites of amino acids. Integration into gas-phase reverse micelles depends upon amino acid hydrophobicity and charge state. For examples, glycine and protonated amino acids (such as protonated tryptophan) are encapsulated within the micellar core via electrostatic interactions; while neutral tryptophan is adsorbed in the surfactant layer. As verified using model polar hydrophobic compounds, the hydrophobic effect and solute-interface hydrogen-bonding do not provide sufficient driving force needed for interfacial solubilization of neutral tryptophan. Neutral tryptophan, with a zwitterionic structure, is intercalated at the micellar interface between surfactant molecules through complementary effects of electrostatic interactions between tryptophan backbone and AOT polar heads, and hydrophobic interactions between tryptophan side chain and AOT alkyl tails. Protonation of tryptophan could significantly improve its incorporation capacity into gas-phase reverse micelles, and displace its incorporation site from the micellar interfacial zone to the core; protonation of glycine, on the other hand, has little effect on its encapsulation capacity. Another interesting observation is that amino acids of different isoelectric points could be selectively encapsulated into, and transported by, reverse micelles from solution to the gas phase, based upon their competition for protonation and subsequent encapsulation within the micellar core. PMID:21140022

  9. Simulation of an ac electro-osmotic pump with step microelectrodes

    NASA Astrophysics Data System (ADS)

    Kim, Byoung Jae; Lee, Seung-Hyun; Rezazadeh, Soghra; Sung, Hyung Jin

    2011-05-01

    Pumps with step microelectrodes subjected to an ac voltage are known to have faster pumping rates than those with planar asymmetric microelectrodes. The driving force for pumping in these systems is ac electro-osmosis. This paper aims to understand the flow behaviors of pumps with step microelectrodes by using a realistic model applicable to high external voltages. This model takes the steric effect due to the finite sizes of ions into account and copes with the exponential sensitivity of the counterion concentration to voltage. The effects on the pumping flow rate of varying the pump parameters were investigated. The geometrical parameters were optimized, and the effects of varying the ac frequency and amplitude were examined. The electrical potential of the fluid and the electrical charge at the electrode surface were solved simultaneously, and the Stokes equation was used to describe the fluid flow.

  10. Study on HCl Driving Force for the Reaction of NaCl-Maleic Acid Mixing Single Droplet Using Micro-FTIR Spectroscopy

    NASA Astrophysics Data System (ADS)

    He, Xiang; Zhang, Yunhong

    2016-04-01

    Chemical aging is the one of the most important physicochemical process in atmospheric aerosols. Mixing of sea salt and water-soluble organic components has profound effects on the volatile characteristic and evolving chemical composition of the anthropogenic origin aerosols, which are poorly understood. In this study, the chemical reaction behavior of the mixture of NaCl and maleic acid (H2MA) micron-level single droplet was investigated using a gas-flow system combined with microscopic Fourier transform infrared (micro-FTIR) spectrometer over the range of relative humidity (63˜95% RH) for the first time. The results showed that the mixture of NaCl and H2MA single droplet could react to form monosodium maleate salt (NaHMA) at the constant RH from the characterization of the FTIR. The reaction is a result of an acid displacement reaction R1, which is driven by high volatility of the HCl product. NaCl(aq)+H2MA(aq)=NaHMA(aq)+HCl(aq,g) (R1) According to the change tendency of the absorbance values of 1579 cm‑1 COO‑ stretching band of the NaHMA dependent upon reaction times at different RHs, the growth range of the trend which could lead to the faster reaction rate was obvious at lower RH. The water content of the droplet was also more likely to reduce rapidly with the loss of the RH from the absorbance changes of 3400 cm‑1H2O stretching band dependent upon reaction times. These may be due to irreversible evaporation of HCl gas which is the main driving force for this type of reaction and the NaHMA is a less hygroscopic component compared to H2MA. And the HCl gas is more likely to evaporate faster from the single droplet and promote the reaction rate and the consumption of water content at lower RH. These results could help in understanding the chemical conversion processes of water-soluble dicarboxylic acids to dicarboxylate salts, as well as the consumption of Cl in sea salt aerosols by organic acids in the atmosphere.

  11. Frequency modulation drive for a piezoelectric motor

    DOEpatents

    Mittas, Anthony

    2001-01-01

    A piezoelectric motor has peak performance at a specific frequency f.sub.1 that may vary over a range of frequencies. A drive system is disclosed for operating such a motor at peak performance without feedback. The drive system consists of the motor and an ac source connected to power the motor, the ac source repeatedly generating a frequency over a range from f.sub.1 -.DELTA.x to f.sub.1 +.DELTA.y.

  12. Quality-Factor Enhancement of Nanoelectromechanical Systems by Capacitive Driving Beyond Resonance

    NASA Astrophysics Data System (ADS)

    Barois, T.; Perisanu, S.; Poncharal, P.; Vincent, P.; Purcell, S. T.; Ayari, A.

    2016-07-01

    Nanoelectromechanical systems are considered as ultrasensitive devices for mass and force detection. Capacitive actuation is widely used in these devices but is known to degrade the quality factor of the resonator due to dc electrostatic damping. We report the enhancement of the quality factor of SiC vibrating nanowires detected nano-optomechanically and electrically by applying an ac capacitive driving at a frequency above both the resonance frequency and the electrical cutoff frequency. Self-oscillations are demonstrated for optimal conditions. We develop an analytical model of the phenomenon and show that it can lead to an improvement of the force sensitivity.

  13. CONTROL ROD DRIVE

    DOEpatents

    Chapellier, R.A.

    1960-05-24

    BS>A drive mechanism was invented for the control rod of a nuclear reactor. Power is provided by an electric motor and an outside source of fluid pressure is utilized in conjunction with the fluid pressure within the reactor to balance the loadings on the motor. The force exerted on the drive mechanism in the direction of scramming the rod is derived from the reactor fluid pressure so that failure of the outside pressure source will cause prompt scramming of the rod.

  14. iDriving (Intelligent Driving)

    2012-09-17

    iDriving identifies the driving style factors that have a major impact on fuel economy. An optimization framework is used with the aim of optimizing a driving style with respect to these driving factors. A set of polynomial metamodels is constructed to reflect the responses produced in fuel economy by changing the driving factors. The optimization framework is used to develop a real-time feedback system, including visual instructions, to enable drivers to alter their driving stylesmore » in responses to actual driving conditions to improve fuel efficiency.« less

  15. iDriving (Intelligent Driving)

    SciTech Connect

    Malikopoulos, Andreas

    2012-09-17

    iDriving identifies the driving style factors that have a major impact on fuel economy. An optimization framework is used with the aim of optimizing a driving style with respect to these driving factors. A set of polynomial metamodels is constructed to reflect the responses produced in fuel economy by changing the driving factors. The optimization framework is used to develop a real-time feedback system, including visual instructions, to enable drivers to alter their driving styles in responses to actual driving conditions to improve fuel efficiency.

  16. Method of driving liquid flow at or near the free surface using magnetic microparticles

    DOEpatents

    Snezhko, Oleksiy; Aronson, Igor; Kwok, Wai-Kwong; Belkin, Maxim V.

    2011-10-11

    The present invention provides a method of driving liquid flow at or near a free surface using self-assembled structures composed of magnetic particles subjected to an external AC magnetic field. A plurality of magnetic particles are supported at or near a free surface of liquid by surface tension or buoyancy force. An AC magnetic field traverses the free surface and dipole-dipole interaction between particles produces in self-assembled snake structures which oscillate at the frequency of the traverse AC magnetic field. The snake structures independently move across the free surface and may merge with other snake structures or break up and coalesce into additional snake structures experiencing independent movement across the liquid surface. During this process, the snake structures produce asymmetric flow vortices across substantially the entirety of the free surface, effectuating liquid flow across the free surface.

  17. Impaired Driving

    MedlinePlus

    ... Risk Factors BAC Effects Prevention Additional Resources How big is the problem? In 2014, 9,967 people ... Driving: A Threat to Everyone (October 2011) Additional Data Drunk Driving State Data and Maps Motor Vehicle ...

  18. Drugged Driving

    MedlinePlus

    ... Infographics » Drugged Driving Drugged Driving Email Facebook Twitter Text Description of Infographic Top Right Figure : In 2009, ... crash than those who don't smoke. Bottom Text: Develop Social Strategies Offer to be a designated ...

  19. Control rod drive

    SciTech Connect

    Hawke, Basil C.

    1986-01-01

    A control rod drive uses gravitational forces to insert one or more control rods upwardly into a reactor core from beneath the reactor core under emergency conditions. The preferred control rod drive includes a vertically movable weight and a mechanism operatively associating the weight with the control rod so that downward movement of the weight is translated into upward movement of the control rod. The preferred control rod drive further includes an electric motor for driving the control rods under normal conditions, an electrically actuated clutch which automatically disengages the motor during a power failure and a decelerator for bringing the control rod to a controlled stop when it is inserted under emergency conditions into a reactor core.

  20. Voight variable speed drive. [for windpowered generator

    NASA Technical Reports Server (NTRS)

    Tompkin, J.

    1973-01-01

    The variable speed drive transmission is mounted within the gondola and connected with the wind turbine blades and the hub. This unit is designed for the production of ac power. The turbine turns by means of the variable speed drive and a set of synchronous three phase generators. This motion is controlled automatically by two wind rosettes in such a way that the wind turbine always opposes the wind direction. The Voight variable speed drive is a mechanical variable positive drive gear transmission. It has an unlimited power and torque transmission, a constant ratio with high degree of accuracy, a speed variation over a wide range, and a nonslip drive.

  1. Pile Driving

    NASA Technical Reports Server (NTRS)

    1987-01-01

    Machine-oriented structural engineering firm TERA, Inc. is engaged in a project to evaluate the reliability of offshore pile driving prediction methods to eventually predict the best pile driving technique for each new offshore oil platform. Phase I Pile driving records of 48 offshore platforms including such information as blow counts, soil composition and pertinent construction details were digitized. In Phase II, pile driving records were statistically compared with current methods of prediction. Result was development of modular software, the CRIPS80 Software Design Analyzer System, that companies can use to evaluate other prediction procedures or other data bases.

  2. 7. VIEW OF THREE BOATHOUSES FROM 'PENN AC ROWING ASSN' ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. VIEW OF THREE BOATHOUSES FROM 'PENN AC ROWING ASSN' TO NORTH END OF 'VESPER,' LOOKING EAST FROM WEST BANK OF SCHUYLKILL RIVER - Boathouse Row, East River Drive, Philadelphia, Philadelphia County, PA

  3. Intermodulation electrostatic force microscopy for imaging surface photo-voltage

    SciTech Connect

    Borgani, Riccardo Forchheimer, Daniel; Thorén, Per-Anders; Haviland, David B.; Bergqvist, Jonas; Inganäs, Olle

    2014-10-06

    We demonstrate an alternative to Kelvin Probe Force Microscopy for imaging surface potential. The open-loop, single-pass technique applies a low-frequency AC voltage to the atomic force microscopy tip while driving the cantilever near its resonance frequency. Frequency mixing due to the nonlinear capacitance gives intermodulation products of the two drive frequencies near the cantilever resonance, where they are measured with high signal to noise ratio. Analysis of this intermodulation response allows for quantitative reconstruction of the contact potential difference. We derive the theory of the method, validate it with numerical simulation and a control experiment, and we demonstrate its utility for fast imaging of the surface photo-voltage on an organic photo-voltaic material.

  4. Electric drive motors for industrial robots

    NASA Astrophysics Data System (ADS)

    Fichtner, K.

    1985-04-01

    In robotized industrial plants it is possible to use electric motors in the technological process and also for control, assembly, transport, testing, and measurements. Particularly suitable for these applications are permanent-magnet d.c. motors. A new special series was developed for industrial robots with hinge joints in kinematic pairs. The complete drive includes thyristors or transistor controls with regulators and, if necessary, a line transformer as well as a servomotor with tachometer and odometer for speed, current, and position control. The drive is coupled to a robot tong through mechanical torque and force converters. In addition to a 0 to 4000 rpm speed regulation, without wobble at low speeds, and a high torque-to-weight ratio for repetitive short-time heavy duty, these low-inertia motors develop high starting and accelerating torques over the entire speed range. They operate from a 1 to O 220 V a.c. line through a rectifier. The motors are totally enclosed, or of open construction for better ventilation. Their windings have class F insulation for operation at ambient temperatures up to 40 C.

  5. Vegetation dynamics and its driving forces from climate change and human activities in the Three-River Source Region, China from 1982 to 2012.

    PubMed

    Zhang, Ying; Zhang, Chaobin; Wang, Zhaoqi; Chen, Yizhao; Gang, Chengcheng; An, Ru; Li, Jianlong

    2016-09-01

    The Three-River Source Region (TRSR), a region with key importance to the ecological security of China, has undergone climate changes and a shift in human activities driven by a series of ecological restoration projects in recent decades. To reveal the spatiotemporal dynamics of vegetation dynamics and calculate the contributions of driving factors in the TRSR across different periods from 1982 to 2012, net primary productivity (NPP) estimated using the Carnegie-Ames-Stanford approach model was used to assess the status of vegetation. The actual effects of different climatic variation trends on interannual variation in NPP were analyzed. Furthermore, the relationships of NPP with different climate factors and human activities were analyzed quantitatively. Results showed the following: from 1982 to 2012, the average NPP in the study area was 187.37gcm(-2)yr(-1). The average NPP exhibited a fluctuation but presented a generally increasing trend over the 31-year study period, with an increase rate of 1.31gcm(-2)yr(-2). During the entire study period, the average contributions of temperature, precipitation, and solar radiation to NPP interannual variation over the entire region were 0.58, 0.73, and 0.09gcm(-2)yr(-2), respectively. Radiation was the climate factor with the greatest influence on NPP interannual variation. The factor that restricted NPP increase changed from temperature and radiation to precipitation. The average contributions of climate change and human activities to NPP interannual variation were 1.40gcm(-2)yr(-2) and -0.08gcm(-2)yr(-2), respectively. From 1982 to 2000, the general climate conditions were favorable to vegetation recovery, whereas human activities had a weaker negative impact on vegetation growth. From 2001 to 2012, climate conditions began to have a negative impact on vegetation growth, whereas human activities made a favorable impact on vegetation recovery. PMID:27135584

  6. Distracted Driving

    MedlinePlus

    ... combines all three types of distraction. 3 How big is the problem? Deaths In 2013, 3,154 ... European countries. More A CDC study analyzed 2011 data on distracted driving, including talking on a cell ...

  7. Distracted driving

    MedlinePlus

    ... stay safe with a cell phone in the car. ... for Disease Control and Prevention Injury Prevention & Control. Motor Vehicle Safety. www.cdc.gov/motorvehiclesafety/distracted_driving . Accessed May ...

  8. Driving Safely

    MedlinePlus

    ... drivers’ flexibility and coordination, and reduced driving errors. S l Hand grip strengthening to help you hold on to the steering wheel l Shoulder and upper arm flexibility exercises to make ...

  9. Head tilt during driving.

    PubMed

    Zikovitz, D C; Harris, L R

    1999-05-01

    In order to distinguish between the use of visual and gravito-inertial force reference frames, the head tilt of drivers and passengers were measured as they went around corners at various speeds. The visual curvature of the corners were thus dissociated from the magnitude of the centripetal forces (0.30-0.77 g). Drivers' head tilts were highly correlated with the visually-available estimate of the curvature of the road (r2=0.86) but not with the centripetal force (r2<0.1). Passengers' head tilts were inversely correlated with the lateral forces (r2=0.3-0.7) and seem to reflect a passive sway. The strong correlation of the tilt of drivers' heads with a visual aspect of the road ahead, supports the use of a predominantly visual reference frame for the driving task. PMID:10722313

  10. Hairless mutation: a driving force of humanization from a human–ape common ancestor by enforcing upright walking while holding a baby with both hands

    PubMed Central

    Sutou, Shizuyo

    2012-01-01

    Three major characteristics distinguish humans from other primates: bipedality, practical nakedness, and the family as a social unit. A hairless mutation introduced into the chimpanzee/human last common ancestor (CLCA) 6 million years ago (Mya) diverged hairless human and hairy chimpanzee lineages. All primates except humans can carry their babies without using their hands. A hairless mother would be forced to stand and walk upright. Her activities would be markedly limited. The male partner would have to collect food and carry it to her by hand to keep her and their baby from starving; irresponsible and selfish males could not have left their offspring. The mother would have sexually accepted her partner at any time as a reward for food. Sexual relations irrespective of estrus cycles might have strengthened the pair bond. Molecular and paleontological dating indicates that CLCA existed 6 Mya, and early hominin fossils show that they were bipeds, indicating that humanization from CLCA occurred rapidly. A single mutation in animals with scalp hair is known to induce hairless phenotype (ectodermal dysplasia). Bipedalism and hairlessness are disadvantageous traits; only those who could survive trials and tribulations in cooperation with family members must have been able to evolve as humans. PMID:22404045

  11. Dielectric Analysis for the Spherical and Rodlike Micelle Aggregates Formed from a Gemini Surfactant: Driving Forces of Micellization and Stability of Micelles.

    PubMed

    Wang, Shanshan; Zhao, Kongshuang

    2016-08-01

    The self-aggregation behavior of Gemini surfactant 12-2-12 (ethanediyl-1,2-bis(dimethyldodecylammonium bromide)) in water was investigated by dielectric relaxation spectroscopy (DRS) over a frequency range from 40 Hz to 110 MHz. Dielectric determination shows that well-defined spherical micelles formed when the concentration of the surfactant was above a critical micelle concentration CMC1 of 3 mM and rodlike micelles formed above CMC2, 16 mM. The formation mechanism of the spherical micelles and their transition mechanism to clubbed micelles were proposed by calculating the degree of counterion binding of the micelles. The interactions between the head groups and the hydrophobic chains of the surfactant led to the formation of the micelles, whereas the transition is mainly attributed to the interaction among the hydrophobic chains. By analyzing the dielectric relaxation observed at about 10(7) Hz based on the interface polarization theory, the permittivity and conductivity of micelle aggregates (spherical and clubbed) and volume fraction of micelles were calculated theoretically as well as the electrical properties of the solution medium. Furthermore, we also calculated the electrokinetic parameters of the micelle particle surface, surface conductivity, surface charge density, and zeta potential, using the relaxation parameters and phase parameters. On the basis of these results, the balance of forces controlling morphological transitions, interfacial electrokinetic properties, and the stability of the micelle aggregates was discussed. PMID:27396495

  12. QPSK modulation for AC-power-signal-biased visible light communication system

    NASA Astrophysics Data System (ADS)

    Liu, Yu-Feng; Yeh, Chien-Hung; Chow, Chi-Wai; Liu, Yang

    2013-01-01

    With the integration of light emitting diode (LED), visible light communication (VLC) can provide wireless communication link using the lightning system. Due to the consideration of power efficiency, AC-LED has the design of reducing energy waste with alternating current from the power outlet. In this work, we propose an AC-power-signalbiased system that provides communication on both DC-LED and AC-LED. The bias circuit is designed to combine ACpower signal and the message signal with QPSK format. This driving scheme needs no AC-to-DC converters and it is suitable for driving AC LED. Synchronization is completed to avoid threshold effect of LED.

  13. Protein-protein interfaces from cytochrome c oxidase I evolve faster than nonbinding surfaces, yet negative selection is the driving force.

    PubMed

    Aledo, Juan Carlos; Valverde, Héctor; Ruíz-Camacho, Manuel; Morilla, Ian; López, Francisco Demetrio

    2014-01-01

    Respiratory complexes are encoded by two genomes (mitochondrial DNA [mtDNA] and nuclear DNA [nDNA]). Although the importance of intergenomic coadaptation is acknowledged, the forces and constraints shaping such coevolution are largely unknown. Previous works using cytochrome c oxidase (COX) as a model enzyme have led to the so-called "optimizing interaction" hypothesis. According to this view, mtDNA-encoded residues close to nDNA-encoded residues evolve faster than the rest of positions, favoring the optimization of protein-protein interfaces. Herein, using evolutionary data in combination with structural information of COX, we show that failing to discern the effects of interaction from other structural and functional effects can lead to deceptive conclusions such as the "optimizing hypothesis." Once spurious factors have been accounted for, data analysis shows that mtDNA-encoded residues engaged in contacts are, in general, more constrained than their noncontact counterparts. Nevertheless, noncontact residues from the surface of COX I subunit are a remarkable exception, being subjected to an exceptionally high purifying selection that may be related to the maintenance of a suitable heme environment. We also report that mtDNA-encoded residues involved in contacts with other mtDNA-encoded subunits are more constrained than mtDNA-encoded residues interacting with nDNA-encoded polypeptides. This differential behavior cannot be explained on the basis of predicted thermodynamic stability, as interactions between mtDNA-encoded subunits contribute more weakly to the complex stability than those interactions between subunits encoded by different genomes. Therefore, the higher conservation observed among mtDNA-encoded residues involved in intragenome interactions is likely due to factors other than structural stability. PMID:25359921

  14. Protein–Protein Interfaces from Cytochrome c Oxidase I Evolve Faster than Nonbinding Surfaces, yet Negative Selection Is the Driving Force

    PubMed Central

    Aledo, Juan Carlos; Valverde, Héctor; Ruíz-Camacho, Manuel; Morilla, Ian; López, Francisco Demetrio

    2014-01-01

    Respiratory complexes are encoded by two genomes (mitochondrial DNA [mtDNA] and nuclear DNA [nDNA]). Although the importance of intergenomic coadaptation is acknowledged, the forces and constraints shaping such coevolution are largely unknown. Previous works using cytochrome c oxidase (COX) as a model enzyme have led to the so-called “optimizing interaction” hypothesis. According to this view, mtDNA-encoded residues close to nDNA-encoded residues evolve faster than the rest of positions, favoring the optimization of protein–protein interfaces. Herein, using evolutionary data in combination with structural information of COX, we show that failing to discern the effects of interaction from other structural and functional effects can lead to deceptive conclusions such as the “optimizing hypothesis.” Once spurious factors have been accounted for, data analysis shows that mtDNA-encoded residues engaged in contacts are, in general, more constrained than their noncontact counterparts. Nevertheless, noncontact residues from the surface of COX I subunit are a remarkable exception, being subjected to an exceptionally high purifying selection that may be related to the maintenance of a suitable heme environment. We also report that mtDNA-encoded residues involved in contacts with other mtDNA-encoded subunits are more constrained than mtDNA-encoded residues interacting with nDNA-encoded polypeptides. This differential behavior cannot be explained on the basis of predicted thermodynamic stability, as interactions between mtDNA-encoded subunits contribute more weakly to the complex stability than those interactions between subunits encoded by different genomes. Therefore, the higher conservation observed among mtDNA-encoded residues involved in intragenome interactions is likely due to factors other than structural stability. PMID:25359921

  15. ACS Quicklook PDF products

    NASA Astrophysics Data System (ADS)

    Suchkov, Anatoly

    1999-12-01

    This report details the features of the ACS quicklook PDF products produced by the HST data pipeline. The requirements closely follow the design of paper products recommended by the Data Quality Committee, with appropriate changes required to fully support ACS.

  16. Probing cellular traction forces with magnetic nanowires and microfabricated force sensor arrays

    NASA Astrophysics Data System (ADS)

    Lin, Yi-Chia; Kramer, Corinne M.; Chen, Christopher S.; Reich, Daniel H.

    2012-02-01

    In this paper, the use of magnetic nanowires for the study of cellular response to force is demonstrated. High-aspect ratio Ni rods with diameter 300 nm and lengths up to 20 μm were bound to or internalized by pulmonary artery smooth muscle cells (SMCs) cultured on arrays of flexible micropost force sensors. Forces and torques were applied to the cells by driving the nanowires with AC magnetic fields in the frequency range 0.1-10 Hz, and the changes in cellular contractile forces were recorded with the microposts. These local stimulations yield global force reinforcement of the cells’ traction forces, but this contractile reinforcement can be effectively suppressed upon addition of a calcium channel blocker, ruthenium red, suggesting the role of calcium channels in the mechanical response. The responsiveness of the SMCs to actuation depends on the frequency of the applied stimulation. These results show that the combination of magnetic nanoparticles and micropatterned, flexible substrates can provide new approaches to the study of cellular mechanotransduction.

  17. Variable frequency drive applications guide

    SciTech Connect

    Laloudakis, D.J.

    1991-10-01

    Traditionally, fans and pumps have been designed to be capable of handling the maximum demand of the system in which they are installed. However, quite often the actual demand can vary and it can be much lower than the original design capacity. These situations have been corrected in the past through additions of outlet dampers to fans or throttling valves to pumps. While these can be effective and simple controls they severely affect the efficiency of the system. Variable frequency (speed) is the most efficient means of capacity control. The most cost effective method of achieving variable speed capacity control is using AC adjustable frequency drives. AC adjustable frequency controls convert any fixed speed AC motor into an adjustable speed device. Adjusting the speed of a motor, by controlling the frequency of the AC power to that motor, reduces its horsepower requirements. According to pump and fan laws, capacity is proportional to speed while horsepower is proportional to the cube of the speed. Therefore, by reducing the speed of an AC motor by 20 percent the horsepower requirement is reduced by nearly 50 percent. Reduced speed through variable frequency control allows for flexibility of meeting changing weather and comfort requirements without operating costly equipment at full capacity.

  18. Transition between locked and running states for dimer motion induced by periodic external driving.

    PubMed

    Hennig, D; Martens, S; Fugmann, S

    2008-07-01

    We study the motion of a dimer in a one-dimensional spatially periodic washboard potential. The tilt of the latter is time-periodically modulated by an ac field. We focus interest on the detrapping of the (static) ground state solution of the dimer caused by the ac field. Moreover, we demonstrate that slow tilt modulations not only induce a trapping-detrapping transition but drive the dimer dynamics into a regime of transient long-range running states. Most strikingly, the motion proceeds then unidirectionally, so that the dimer covers huge distances regardless of the fact that the bias force in the driven system vanishes on the average. We elucidate the underlying dynamics in phase space and associate long-lasting running states with the motion in ballistic channels occurring due to stickiness to invariant tori. PMID:18763916

  19. Stochastic Dynamics of DC and AC Driven Dislocation Kinks

    NASA Astrophysics Data System (ADS)

    Vardanyan, A.; Kteyan, A.

    2013-02-01

    Dynamics of a pinned dislocation kink controlled by the acting DC and AC forces is studied analytically. The motion of the kink, described by sine-Gordon (sG) equation, is explored within the framework of McLaughlin-Scott perturbation theory. Assuming weakness of the acting AC force, the equation of motion of the dislocation kink in the pinning potential is linearized. Based on the equations derived, we study stochastic behavior of the kink, and determine the probability of its depinning. The dependencies of the depinning probability on DC and AC forces are analyzed in detail.

  20. Electric vehicle drive train with contactor protection

    DOEpatents

    Konrad, C.E.; Benson, R.A.

    1994-11-29

    A drive train for an electric vehicle includes a traction battery, a power drive circuit, a main contactor for connecting and disconnecting the traction battery and the power drive circuit, a voltage detector across contacts of the main contactor, and a controller for controlling the main contactor to prevent movement of its contacts to the closed position when the voltage across the contacts exceeds a predetermined threshold, to thereby protect the contacts of the contactor. The power drive circuit includes an electric traction motor and a DC-to-AC inverter with a capacitive input filter. The controller also inhibits the power drive circuit from driving the motor and thereby discharging the input capacitor if the contacts are inadvertently opened during motoring. A precharging contactor is controlled to charge the input filter capacitor prior to closing the main contactor to further protect the contacts of the main contactor. 3 figures.

  1. Electric vehicle drive train with contactor protection

    DOEpatents

    Konrad, Charles E.; Benson, Ralph A.

    1994-01-01

    A drive train for an electric vehicle includes a traction battery, a power drive circuit, a main contactor for connecting and disconnecting the traction battery and the power drive circuit, a voltage detector across contacts of the main contactor, and a controller for controlling the main contactor to prevent movement of its contacts to the closed position when the voltage across the contacts exceeds a predetermined threshold, to thereby protect the contacts of the contactor. The power drive circuit includes an electric traction motor and a DC-to-AC inverter with a capacitive input filter. The controller also inhibits the power drive circuit from driving the motor and thereby discharging the input capacitor if the contacts are inadvertently opened during motoring. A precharging contactor is controlled to charge the input filter capacitor prior to closing the main contactor to further protect the contacts of the main contactor.

  2. [Using the 'Driving Force - Pressure - State - Exposure - Effects - Action' (DPSEEA) model of the World Health Organization (WHO) for the analysis of risks related to the use of pesticides in agricultural activities in the state of Rio de Janeiro].

    PubMed

    Araújo-Pinto, Mariana de; Peres, Frederico; Moreira, Josino Costa

    2012-06-01

    This paper seeks to apply the DPSEEA model (WHO) to identify major health risks to rural workers and the environment associated with the intensive use of pesticides in the State of Rio de Janeiro, based on an analysis of official public documents and a review of the (national and international) literature. It emphasizes the two main representative branches of agriculture in the state: family farming in the mountain region and the monoculture of sugarcane in the flatlands. Results show that the bulk of the determinants identified in the DPSEEA Matrix are related to deficiencies in actions for monitoring and surveillance of pesticide use, as well as a lack of technical assistance provided by the Public Sector in Rio de Janeiro State. Most of the actions developed in the state address the effects of pesticide exposure and, to a lesser extent, exposure to these chemicals, failing to focus on the higher levels of the matrix (such as driving forces and pressure). These are considered, by several authors, as the most appropriate when tackling the complex and systemic issues, such as the scope of this paper. By means of this study, an attempt was made to enable the application of the DPSEEA Model to assist in environmental and occupational health surveillance initiatives. PMID:22699645

  3. Pattern-formation under acoustic driving forces

    NASA Astrophysics Data System (ADS)

    Valverde, Jose Manuel

    2015-07-01

    Chemical and metallurgical processes enhanced by high intensity acoustic waves, thermoacoustic engines and refrigerators, fuel rods in nuclear reactors, heat exchanger tubes, offshore and vibrating structures, solar thermal collectors, acoustic levitators, microfluidic devices, cycling, musical acoustics, blood flow through veins/arteries, hearing in the mammalian ear, carbon nanotube loudspeakers, etc. The evolution of a myriad of processes involving the oscillation of viscous fluids in the presence of solid boundaries is up to a certain extent influenced by acoustic streaming. In addition to the sound field, viscous energy dissipation at the fluid-solid boundary causes a time-independent fluid circulation, which can lead to a significant enhancement of heat, mass and momentum transfer at large oscillation amplitudes. A particularly relevant phenomenon that can be notably affected by acoustic streaming is the promotion of sound waves by temperature gradients or viceversa (thermoacoustics), which is at the basis of potentially efficient and environmental friendly engines and refrigerators that have attracted a renewed interest in the last years. In the present manuscript, historical developments and the underlying basic physics behind acoustic streaming and thermoacoustics are reviewed from an unifying perspective.

  4. The community as a driving force.

    PubMed

    1993-12-01

    A Workshop on Effective Strategies for Sustainable Community-based Family Planning (FP) and Maternal and Child Health (MCH) was held on October 14-23, 1993, as part of an Asian regional project focusing on women. Bangladesh, China, Laos, Nepal, the Philippines, and Viet Nam were represented at the workshop. The program introduced participants to effective community participation strategies in FP and MCH in Indonesia and allowed for the exchange of information. The UN Population Fund expressed support and encouragement for the exchange and recognition of Indonesia's government support for efforts at regional exchanges. Indonesia established integrated service posts or "Posyandu" in villages during the 1980s for women volunteers as health advocates. FP/MCH was later integrated in these health posts. The service posts aim to reduce infant mortality and maternal mortality through growth monitoring of children aged under five years, provision of FP, nutrition services for pregnant mothers, immunization, and monitoring of high-risk pregnancies. Trained volunteers and community people are aides to either government personnel or nongovernmental (NGO) workers. The Indonesian government FP program evolved from a program "for" the people, to "with" the people, and finally "by" the people. Fees for contraception, which are still below retail prices, are being introduced as a means of achieving sustainability. The government trains doctors and midwives in FP. NGOs such as Yayasan Kusuma Buana (YKB) in Jakarta provide a mix of quality services. YKB is active in promoting awareness of FP. Community outreach is achieved through mothers' classes, urban Posyandu services, and training of traditional birth attendants. The Indonesian Planned Parenthood Association maintains self-reliance programs in FP/MCH. Day-care centers and youth counseling centers are used in promoting FP/MCH. YKB methods were demonstrated for workshop participants (posters used in local shops and awareness activities for school health programs). Workshop participants were exposed to many activities in FP/MCH. Participants learned the importance of government commitment and the importance of people's acceptance that FP is necessary for improving the quality of life. PMID:12287329

  5. On the driving force of PAH production

    NASA Technical Reports Server (NTRS)

    Frenklach, Michael

    1989-01-01

    The kinetic factors affecting the production of polycyclic aromatic hydrocarbons (PAH) in high-temperature pyrolysis and combustion environments are analyzed. A lumped kinetic model representing polymerization-type growth by one irreversible step and two reversible steps is considered. It is shown that at high temperatures, PAH growth is controlled by the superequilibrium of hydrogen atoms; at low temperatures and low H2 concentrations, the PAH growth rate is proportional to the rate of the H-abstraction of a hydrogen atom from aromatic molecules; while at low temperatures and high H2 concentrations, it is controlled by the thermodynamics of the H-abstraction and the kinetics of acetylene addition to aromatic radicals. The presence of oxygen mainly affects the small-molecule reactions during the induction period.

  6. Refiners respond to strategic driving forces

    SciTech Connect

    Gonzalez, R.G.

    1996-05-01

    Better days should lie ahead for the international refining industry. While political unrest, lingering uncertainty regarding environmental policies, slowing world economic growth, over capacity and poor image will continue to plague the industry, margins in most areas appear to have bottomed out. Current margins, and even modestly improved margins, do not cover the cost of capital on certain equipment nor provide the returns necessary to achieve reinvestment economics. Refiners must determine how to improve the financial performance of their assets given this reality. Low margins and returns are generally characteristic of mature industries. Many of the business strategies employed by emerging businesses are no longer viable for refiners. The cost-cutting programs of the `90s have mainly been realized, leaving little to be gained from further reduction. Consequently, refiners will have to concentrate on increasing efficiency and delivering higher value products to survive. Rather than focusing solely on their competition, companies will emphasize substantial improvements in their own operations to achieve financial targets. This trend is clearly shown by the growing reliance on benchmarking services.

  7. Collaboration: The Driving Force for Success

    ERIC Educational Resources Information Center

    Rourke, James; Boone, Elizabeth

    2008-01-01

    Nestled in the mountains and surrounded by Christmas tree farms, Ashe County Middle School is a small, rural school in the far northwest corner of North Carolina. Recognized nationally for its fine academic and co-curricular programs, the school prepares students for high school and real-life situations by teaching important concepts, essential…

  8. Inflammation: a driving force speeds cancer metastasis

    PubMed Central

    Wu, Yadi; Zhou, Binhua P.

    2013-01-01

    It has been increasingly recognized that tumor microenvironment plays an important role in carcinogenesis. Inflammatory component is present and contributes to tumor proliferation, angiogenesis, metastasis, and resistance to hormonal and chemotherapy. This review highlights the role of inflammation in the tumor metastasis. We focus on the function of proinflammatory factors, particularly cytokines during tumor metastasis. Understanding of the mechanisms by which inflammation contributes to metastasis will lead to innovative approach for treating cancer. PMID:19770594

  9. Corporate Universities: Driving Force of Knowledge Innovation

    ERIC Educational Resources Information Center

    Rademakers, Martijn

    2005-01-01

    Purpose: This paper aims to explain the rapid emergence of corporate universities on the basis of fundamental developments presently shaping the economy and society on a world-wide scale. Design/methodology/approach: Four key forms of innovation are identified and combined with the corporate university concept. The paper explains why corporate…

  10. SCM-Forcing Data

    DOE Data Explorer

    Xie, Shaocheng; Tang,Shuaiqi; Zhang,Yunyan; Zhang,Minghua

    2016-07-01

    Single-Column Model (SCM) Forcing Data are derived from the ARM facility observational data using the constrained variational analysis approach (Zhang and Lin 1997 and Zhang et al., 2001). The resulting products include both the large-scale forcing terms and the evaluation fields, which can be used for driving the SCMs and Cloud Resolving Models (CRMs) and validating model simulations.

  11. An AC magnetohydrodynamic micropump: towards a true integrated microfluidic system

    SciTech Connect

    Lee, A P; Lemoff, A V; McConaghy, C F; Miles, R R

    1999-03-01

    An AC Magnetohydrodynamic (MHD) micropump has been demonstrated in which the Lorentz force is used to propel an electrolytic solution along a microchannel etched in silicon. This micropump has no moving parts, produces a continuous (not pulsatile) flow, and is compatible with solutions containing biological specimens. micropump, using the Lorentz force as the pumping mechanism for biological analysis. The AC Magnetohydrodynamic (MHD) micropump investigated produces a continuous flow and allows for complex microchannel design.

  12. Metal band drives in spacecraft mechanisms

    NASA Technical Reports Server (NTRS)

    Maus, Daryl

    1993-01-01

    Transmitting and changing the characteristics of force and stroke is a requirement in nearly all mechanisms. Examples include changing linear to rotary motion, providing a 90 deg change in direction, and amplifying stroke or force. Requirements for size, weight, efficiency and reliability create unique problems in spacecraft mechanisms. Flexible metal band and cam drive systems provide powerful solutions to these problems. Band drives, rack and pinion gears, and bell cranks are compared for effectiveness. Band drive issues are discussed including materials, bend radius, fabrication, attachment and reliability. Numerous mechanisms are shown which illustrate practical applications of band drives.

  13. Input Power Quality Improvement in Switched Reluctance Motor Drive using Minnesota Rectifier

    NASA Astrophysics Data System (ADS)

    Singh, B.; Rajesh, M.

    2013-09-01

    This paper deals with an input power quality improvement in a midpoint converter based switched reluctance motor (SRM) drive at ac mains using Minnesota rectifier. Normally a midpoint converter is used as a power converter for SRM drive. Conventionally three phase ac mains fed bridge rectifier is used as a dc source to feed this power converter which produces high content of harmonics at ac mains with a very low power factor. The proposed Minnesota rectifier with a midpoint converter fed SRM drive improves the power factor at ac mains with low current harmonics. This method provides constant dc link voltage and balanced capacitor voltages of the midpoint converter. The Minnesota rectifier fed SRM drive is modelled and its performance is simulated in Matlab/Simulink environment. The performance of Minnesota rectifier is compared with a conventional bridge topology for SRM drive to demonstrate improved power quality at ac mains.

  14. The Thermodynamics of Drunk Driving

    NASA Astrophysics Data System (ADS)

    Thompson, Robert Q.

    1997-05-01

    Chemical and instrumental tests for driving under the influence of alcohol (DUI) measure the concentration of ethanol in the breath (BrAC), while state DUI laws are described in terms of blood alcohol concentration (BAC). Consequently, accurate and fair conversion from BrAC to BAC is crucial to the judicial process. Theoretical treatment of the water-air-ethanol equilibrium system and the related blood-breath-ethanol system, based on principles from general chemistry and biology, yields an equation relating the ratio of BAC to BrAC to the absolute temperature of the breath, the fraction of water in the blood, and the enthalpy and entropy of vaporization of ethanol from aqueous solution. The model equation predicts an average value for the ratio of 2350+100, not significantly different from reported experimental values. An exponential temperature dependence is predicted and has been confirmed experimentally as well. Biological, chemical, and instrumental variables are described along with their contributions to the overall uncertainty in the value of BrAC/BAC. While the forensic science community uses, and debates, a fixed ratio of 2100, the theoretical model suggests that a value of 1880 should be used to reduce the fraction of false positives to <1%.

  15. Landau-Zener interference at bichromatic driving

    NASA Astrophysics Data System (ADS)

    Forster, Florian; Mühlbacher, Max; Blattmann, Ralf; Schuh, Dieter; Wegscheider, Werner; Ludwig, Stefan; Kohler, Sigmund

    2015-12-01

    We investigate experimentally and theoretically the interference at avoided crossings which are repeatedly traversed as a consequence of an applied ac field. Our model system is a charge qubit in a serial double quantum dot connected to two leads. Our focus lies on effects caused by simultaneous driving with two different frequencies. We work out how the commensurability of the driving frequencies affects the symmetry of the interference patterns both in real space and in Fourier space. For commensurable frequencies, the symmetry depends sensitively on the relative phase between the two modes, whereas for incommensurable frequencies the symmetry of monochromatic driving is always recovered.

  16. Characterization of New Isolates of Apricot vein clearing-associated virus and of a New Prunus-Infecting Virus: Evidence for Recombination as a Driving Force in Betaflexiviridae Evolution.

    PubMed

    Marais, Armelle; Faure, Chantal; Mustafayev, Eldar; Candresse, Thierry

    2015-01-01

    Double stranded RNAs from Prunus samples gathered from various surveys were analyzed by a deep-sequencing approach. Contig annotations revealed the presence of a potential new viral species in an Azerbaijani almond tree (Prunus amygdalus) and its genome sequence was completed. Its genomic organization is similar to that of the recently described Apricot vein clearing associated virus (AVCaV) for which two new isolates were also characterized, in a similar fashion, from two Japanese plums (Prunus salicina) from a French germplasm collection. The amino acid identity values between the four proteins encoded by the genome of the new virus have identity levels with those of AVCaV which fall clearly outside the species demarcation criteria. The new virus should therefore be considered as a new species for which the name of Caucasus prunus virus (CPrV) has been proposed. Phylogenetic relationships and nucleotide comparisons suggested that together with AVCaV, CPrV could define a new genus (proposed name: Prunevirus) in the family Betaflexiviridae. A molecular test targeting both members of the new genus was developed, allowing the detection of additional AVCaV isolates, and therefore extending the known geographical distribution and the host range of AVCaV. Moreover, the phylogenetic trees reconstructed with the amino acid sequences of replicase, movement and coat proteins of representative Betaflexiviridae members suggest that Citrus leaf blotch virus (CLBV, type member of the genus Citrivirus) may have evolved from a recombination event involving a Prunevirus, further highlighting the importance of recombination as a driving force in Betaflexiviridae evolution. The sequences reported in the present manuscript have been deposited in the GenBank database under accession numbers KM507061-KM504070. PMID:26086395

  17. Characterization of New Isolates of Apricot vein clearing-associated virus and of a New Prunus-Infecting Virus: Evidence for Recombination as a Driving Force in Betaflexiviridae Evolution

    PubMed Central

    Marais, Armelle; Faure, Chantal; Mustafayev, Eldar; Candresse, Thierry

    2015-01-01

    Double stranded RNAs from Prunus samples gathered from various surveys were analyzed by a deep-sequencing approach. Contig annotations revealed the presence of a potential new viral species in an Azerbaijani almond tree (Prunus amygdalus) and its genome sequence was completed. Its genomic organization is similar to that of the recently described Apricot vein clearing associated virus (AVCaV) for which two new isolates were also characterized, in a similar fashion, from two Japanese plums (Prunus salicina) from a French germplasm collection. The amino acid identity values between the four proteins encoded by the genome of the new virus have identity levels with those of AVCaV which fall clearly outside the species demarcation criteria. The new virus should therefore be considered as a new species for which the name of Caucasus prunus virus (CPrV) has been proposed. Phylogenetic relationships and nucleotide comparisons suggested that together with AVCaV, CPrV could define a new genus (proposed name: Prunevirus) in the family Betaflexiviridae. A molecular test targeting both members of the new genus was developed, allowing the detection of additional AVCaV isolates, and therefore extending the known geographical distribution and the host range of AVCaV. Moreover, the phylogenetic trees reconstructed with the amino acid sequences of replicase, movement and coat proteins of representative Betaflexiviridae members suggest that Citrus leaf blotch virus (CLBV, type member of the genus Citrivirus) may have evolved from a recombination event involving a Prunevirus, further highlighting the importance of recombination as a driving force in Betaflexiviridae evolution. The sequences reported in the present manuscript have been deposited in the GenBank database under accession numbers KM507061-KM504070. PMID:26086395

  18. Novel method for driving the ultrasonic motor.

    PubMed

    Kim, Hyeoung woo; Dong, Shuxiang; Laoratanakul, Pitak; Uchino, Kenji; Park, Tae gone

    2002-10-01

    This paper reports a novel driving method for an annular plate-type ultrasonic motor. Instead of the direct current/alternating current (DC/AC) converter type driver using conventional electromagnetic transformer, a compact disc-type piezoelectric transformer is used to obtain high voltage output for driving the ultrasonic motor. The piezoelectric transformer is operated in the radial vibration mode at resonance frequency close to the resonance frequency of the ultrasonic motor. Later, it was found that the piezoelectric transformer could drive the ultrasonic motor, even if their resonance frequencies are not exactly the same by incorporating the matching network in the circuit. The maximum speed of the ultrasonic motor obtained by using this driving method is over 300 rpm. It is believed that the results of this study will have impact on the integration and miniaturization of the ultrasonic motor and its driving circuit. PMID:12403137

  19. Dementia and driving

    MedlinePlus

    ... not drive at times of the day when traffic is heaviest. Do not drive when the weather is bad. Do not drive long distances. Drive only on roads the person is used to. Caregivers should try to lessen ...

  20. Microfabricated AC impedance sensor

    DOEpatents

    Krulevitch, Peter; Ackler, Harold D.; Becker, Frederick; Boser, Bernhard E.; Eldredge, Adam B.; Fuller, Christopher K.; Gascoyne, Peter R. C.; Hamilton, Julie K.; Swierkowski, Stefan P.; Wang, Xiao-Bo

    2002-01-01

    A microfabricated instrument for detecting and identifying cells and other particles based on alternating current (AC) impedance measurements. The microfabricated AC impedance sensor includes two critical elements: 1) a microfluidic chip, preferably of glass substrates, having at least one microchannel therein and with electrodes patterned on both substrates, and 2) electrical circuits that connect to the electrodes on the microfluidic chip and detect signals associated with particles traveling down the microchannels. These circuits enable multiple AC impedance measurements of individual particles at high throughput rates with sufficient resolution to identify different particle and cell types as appropriate for environmental detection and clinical diagnostic applications.

  1. Camshaft driving device for internal combustion engine

    SciTech Connect

    Ebesu, H.

    1988-06-14

    A camshaft driving device for use in a double overhead cam type internal combustion engine having a cylinder block, an upper deck formed at an upper portion of the cylinder block, a cylinder head disposed on the cylinder block, a driving shaft rotatably mounted at a lower portion of the cylinder block, and a pair of camshafts rotatably mounted at an upper portion of the cylinder head, is described comprising: driving force transmitting endless chain members engaging in the reduction gear means for transmitting a driving force from the driving shaft to the pair of camshaft through the reduction gear means. The camshaft driving device further including chain tensioners for tightening the chain, a nozzle means for supplying a lubricating oil to the driving force chain members on the side of the drive shaft and an oil guide wall formed immediately above the sprocket of the transmitting portion of the reduction gear means at a lower end portion of the journal boss and lapping thereover both in the radial direction and in the axial direction of the driving shaft. A mounting boss for mounting the reduction gear means thereon is formed on the upper deck of the cylinder block.

  2. Design and construction of shaft-driving type piezoceramic ultrasonic motor.

    PubMed

    Wen, Fuh-Liang; Mou, Shann-Chyi; Ouyang, Minsun

    2004-10-01

    A new approach in design of shaft-driving type piezoceramic ultrasonic motor is proposed. The stator of motor consisted of a commercial available buzzer disk in which a piezoceramic membrane is adhered to a metal sheet. The wave propagation on the metal sheet was generated by extended-shrunk force from piezoceramic oscillation. Driving energy came from the vibration modes by mechanical-electrical oscillation of the metal sheet in corresponding to converse piezoelectric effect using a single-phase AC voltage power. Where the relative elliptic motion was occurred between the bearing seat and rotor in order to kinematical delivery, the rotor being driven was connected directly on the bearing seat to transmit the dynamic power with frictional contact force. In analysis of dynamic features, the system transfer function of admittance and equivalent circuit was obtained. The rotating speed of the prototype motor could be reached as high as 2000 rpm on the driving condition of 72 kHz, +/-10 V(pp), and 0.2 A. The maximum torque was less than 0.003 Nm. It could be utilized in the driver of CD, or the cooling fan in the computer CPU. PMID:15358527

  3. ACS Symposium Support

    SciTech Connect

    Kenneth D. Jordan

    2010-02-20

    The funds from this DOE grant were used to help cover the travel costs of five students and postdoctoral fellows who attended a symposium on 'Hydration: From Clusters to Aqueous Solutions' held at the Fall 2007 American Chemical Society Meeting in Boston, MA, August 19-23. The Symposium was sponsored by the Physical Chemistry Division, ACS. The technical program for the meeting is available at http://phys-acs.org/fall2007.html.

  4. Manipulating Flames with AC Electric Fields

    NASA Astrophysics Data System (ADS)

    Bishop, Kyle

    2013-11-01

    Time-oscillating electric fields applied to plasmas present in flames create steady flows of gas capable of shaping, directing, enhancing, or even extinguishing flames. Interestingly, electric winds induced by AC electric fields can be stronger that those due to static fields of comparable magnitude. Furthermore, unlike static fields, the electric force due to AC fields is localized near the surface of the flame. Consequently, the AC response depends only on the local field at the surface of the flame - not on the position of the electrodes used to generate the field. These results suggest that oscillating electric fields can be used to manipulate and control combustion processes at a distance. To characterize and explain these effects, we investigate a simple experimental system comprising a laminar methane-air flame positioned between two parallel-plate electrodes. We quantify both the electric and hydrodynamic response of the flame as a function of frequency and magnitude of the applied field. A theoretical model shows how steady gas flows emerge from the time-averaged electrical force due to the field-induced motion of ions generated within the flame and by their disappearance by recombination. These results provide useful insights into the application of AC fields to direct combustion processes.

  5. IMPROVING AC MOTOR EFFICIENCY WITH FUZZY LOGIC ENERGY OPTIMIZER

    EPA Science Inventory

    The paper discusses EPA's research program to develop fuzzy-logic-based energy optimizers for alternating-current (AC) induction motors driven by Adjustable Speed Drives (ASDs). he technical goals of the program are to increase the efficiency of ASD/motor combinations (especially...

  6. How mantle slabs drive plate tectonics.

    PubMed

    Conrad, Clinton P; Lithgow-Bertelloni, Carolina

    2002-10-01

    The gravitational pull of subducted slabs is thought to drive the motions of Earth's tectonic plates, but the coupling between slabs and plates is not well established. If a slab is mechanically attached to a subducting plate, it can exert a direct pull on the plate. Alternatively, a detached slab may drive a plate by exciting flow in the mantle that exerts a shear traction on the base of the plate. From the geologic history of subduction, we estimated the relative importance of "pull" versus "suction" for the present-day plates. Observed plate motions are best predicted if slabs in the upper mantle are attached to plates and generate slab pull forces that account for about half of the total driving force on plates. Slabs in the lower mantle are supported by viscous mantle forces and drive plates through slab suction. PMID:12364804

  7. New levitation scheme with AC superconducting magnet for EDS MAGLEV system

    SciTech Connect

    Kim, D.H.; Lee, J.K.; Hahn, S.Y.; Cha, G.

    1996-09-01

    This paper proposes a new magnetic levitation scheme which is able to generate levitation force for all speeds including a standstill. Auxiliary wheels which are needed in EDS MAGLEV vehicle can be eliminated. This scheme uses AC superconducting magnets to generate levitation force. In this paper, magnetic fields, forces and power dissipations generated by AC magnets moving above a conducting slab are calculated analytically. Results of calculation show characteristics of EDS system with AC magnet, such as levitation force and loss, are superior to those of EDS system with DC magnets for all speeds.

  8. Simulation of Trolleybus Traction Induction Drive With Supercapacitor Energy Storage System

    NASA Astrophysics Data System (ADS)

    Brazis, V.; Latkovskis, L.; Grigans, L.

    2010-01-01

    The article considers the possibilities of saving the regenerative braking energy in Škoda 24Tr type trolleybuses by installing the onboard supercapacitor energy storage system (ESS) and improving its performance with automated switching to the autonomous traction mode. Proposed is an ESS control system with constant DC bus voltage in the supercapacitor charging mode and supercapacitor current proportional to the AC drive current in the discharging mode. The authors investigate stability of the trolleybus ESS control system operating together with AC traction drive in various overhead voltage failure modes. The co-simulation of ESS operation was done by Matlab/Simulink AC drive and PSIM ESS continuous models.

  9. Magnetostrictive direct drive motors

    NASA Technical Reports Server (NTRS)

    Naik, Dipak; Dehoff, P. H.

    1992-01-01

    A new rare earth alloy, Terfenol-D, combines low frequency operation and extremely high energy density with high magnetostriction. Its material properties make it suitable as a drive element for actuators requiring high output torque. The high strains, the high forces and the high controllability of Terfenol alloys provide a powerful and challenging basis for new ways to generate motion in actuators. Two prototypes of motors using Terfenol-D rods were developed at NASA Goddard. The basic principles of operation are provided of the motor along with other relevant details. A conceptual design of a torque limiting safety clutch/brake under development is illustrated. Also, preliminary design drawings of a linear actuator using Terfenol-D is shown.

  10. QUICK RELEASABLE DRIVE

    DOEpatents

    Dickson, J.J.

    1958-07-01

    A quick releasable mechanical drive system suitable for use in a nuclear reactor is described. A small reversible motor positions a control rod by means of a worm and gear speed reducer, a magnetic torque clutch, and a bell crank. As the control rod is raised to the operating position, a heavy coil spring is compressed. In the event of an emergency indicated by either a''scram'' signal or a power failure, the current to the magnetic clutch is cut off, thereby freeing the coil spring and the bell crank positioner from the motor and speed reduction gearing. The coil spring will immediately act upon the bell crank to cause the insertion of the control rod. This arrangement will allow the slow, accurate positioning of the control rod during reactor operation, while providing an independent force to rapidly insert the rod in the event of an emergency.

  11. Future trends in adjustable speed drives

    SciTech Connect

    Murphy, H.G.

    1995-12-31

    Adjustable speed drives are an evolving technology stimulated by the demand for improved process control and tempered by environmental conditions--an evolution controlled by the dynamics of electrical power, power devices and traditional control methods. How these factors interact controls future trends and product offerings for a variety of adjustable speed motor controllers. With the topic of adjustable speed motor controllers` a reasonable place to start would be with the motor. Although many types of motors can be used for variable speed applications, this paper will focus on the ac motor and the electronic controllers associated with ac motors. Both frequency and voltage are controllable motor parameters. Controlling either or both can improve the performance of the ac motor within a given application. Each type of controller offers a unique set of advantages and disadvantages, however, the simultaneous control of frequency and voltage provides the greatest benefits. The adjustable speed controller that provides simultaneous control of frequency and voltage for ac motors is the AFD or adjustable frequency drive.

  12. Tevatron AC dipole system

    SciTech Connect

    Miyamoto, R.; Kopp, S.E.; Jansson, A.; Syphers, M.J.; /Fermilab

    2007-06-01

    The AC dipole is an oscillating dipole magnet which can induce large amplitude oscillations without the emittance growth and decoherence. These properties make it a good tool to measure optics of a hadron synchrotron. The vertical AC dipole for the Tevatron is powered by an inexpensive high power audio amplifier since its operating frequency is approximately 20 kHz. The magnet is incorporated into a parallel resonant system to maximize the current. The use of a vertical pinger magnet which has been installed in the Tevatron made the cost relatively inexpensive. Recently, the initial system was upgraded with a more powerful amplifier and oscillation amplitudes up to 2-3{sigma} were achieved with the 980 GeV proton beam. This paper discusses details of the Tevatron AC dipole system and also shows its test results.

  13. The Energetics of Motivated Cognition: A Force-Field Analysis

    ERIC Educational Resources Information Center

    Kruglanski, Arie W.; Belanger, Jocelyn J.; Chen, Xiaoyan; Kopetz, Catalina; Pierro, Antonio; Mannetti, Lucia

    2012-01-01

    A force-field theory of motivated cognition is presented and applied to a broad variety of phenomena in social judgment and self-regulation. Purposeful cognitive activity is assumed to be propelled by a "driving force" and opposed by a "restraining force". "Potential" driving force represents the maximal amount of energy an individual is prepared…

  14. ac bidirectional motor controller

    NASA Technical Reports Server (NTRS)

    Schreiner, K.

    1988-01-01

    Test data are presented and the design of a high-efficiency motor/generator controller at NASA-Lewis for use with the Space Station power system testbed is described. The bidirectional motor driver is a 20 kHz to variable frequency three-phase ac converter that operates from the high-frequency ac bus being designed for the Space Station. A zero-voltage-switching pulse-density-modulation technique is used in the converter to shape the low-frequency output waveform.

  15. Efficient Driving of Piezoelectric Transducers Using a Biaxial Driving Technique

    PubMed Central

    2015-01-01

    Efficient driving of piezoelectric materials is desirable when operating transducers for biomedical applications such as high intensity focused ultrasound (HIFU) or ultrasound imaging. More efficient operation reduces the electric power required to produce the desired bioeffect or contrast. Our preliminary work [Cole et al. Journal of Physics: Condensed Matter. 2014;26(13):135901.] suggested that driving transducers by applying orthogonal electric fields can significantly reduce the coercivity that opposes ferroelectric switching. We present here the experimental validation of this biaxial driving technique using piezoelectric ceramics typically used in HIFU. A set of narrow-band transducers was fabricated with two sets of electrodes placed in an orthogonal configuration (following the propagation and the lateral mode). The geometry of the ceramic was chosen to have a resonance frequency similar for the propagation and the lateral mode. The average (± s.d.) resonance frequency of the samples was 465.1 (± 1.5) kHz. Experiments were conducted in which each pair of electrodes was driven independently and measurements of effective acoustic power were obtained using the radiation force method. The efficiency (acoustic/electric power) of the biaxial driving method was compared to the results obtained when driving the ceramic using electrodes placed only in the pole direction. Our results indicate that the biaxial method increases efficiency from 50% to 125% relative to the using a single electric field. PMID:26418550

  16. Efficient Driving of Piezoelectric Transducers Using a Biaxial Driving Technique.

    PubMed

    Pichardo, Samuel; Silva, Rafael R C; Rubel, Oleg; Curiel, Laura

    2015-01-01

    Efficient driving of piezoelectric materials is desirable when operating transducers for biomedical applications such as high intensity focused ultrasound (HIFU) or ultrasound imaging. More efficient operation reduces the electric power required to produce the desired bioeffect or contrast. Our preliminary work [Cole et al. Journal of Physics: Condensed Matter. 2014;26(13):135901.] suggested that driving transducers by applying orthogonal electric fields can significantly reduce the coercivity that opposes ferroelectric switching. We present here the experimental validation of this biaxial driving technique using piezoelectric ceramics typically used in HIFU. A set of narrow-band transducers was fabricated with two sets of electrodes placed in an orthogonal configuration (following the propagation and the lateral mode). The geometry of the ceramic was chosen to have a resonance frequency similar for the propagation and the lateral mode. The average (± s.d.) resonance frequency of the samples was 465.1 (± 1.5) kHz. Experiments were conducted in which each pair of electrodes was driven independently and measurements of effective acoustic power were obtained using the radiation force method. The efficiency (acoustic/electric power) of the biaxial driving method was compared to the results obtained when driving the ceramic using electrodes placed only in the pole direction. Our results indicate that the biaxial method increases efficiency from 50% to 125% relative to the using a single electric field. PMID:26418550

  17. Electric vehicle drive train components

    SciTech Connect

    Silver, F.

    1994-12-31

    Power Control Systems has developed a family of electric vehicle drive systems that range from 65 horsepower through 300 horse power. These propulsion systems support vehicle applications ranging from light cars and pickups to buses and trucks weighing as much as 40,000 lbs (18,400 kg). These robust systems are designed specifically for automotive applications including safety, electromagnetic emissions, and environment ruggedness. Dolphin Drive Systems are very flexible. Their inverter controllers are programmable and can be provided as stand alone components matched to customer specified motors. A selection of pre-calibrated systems including motor and inverter/controller can be provided. Accessory tools are also available for customer self programming. Dolphin Drive Systems provide precision control of AC induction motors providing excellent torque-speed performance usually eliminating the need for multistage transmissions. In addition, they are very efficient over a wide speed/torque range. This provides for excellent power management over a variety of continuous speed and stop and go applications.

  18. Force measurements during vibration testing

    SciTech Connect

    Smallwood, D.O.; Coleman, R.G.

    1993-12-31

    Experimental measurements of force into a ``rigid`` test item representing a typical system level vibration test were conducted to evaluate several methods of force measurements. The methods evaluated included: (1) Direct measurement with force gages between the test item and the fixturing; (2) Measurement of the force at the shaker/fixture interface and correcting the force required to drive the fixturing using two methods, (a) mass subtraction and (b) SWAT (sum of weighted accelerations technique), (3) Force deduced from voltage and current needed to drive the test item. All of the methods worked over a limited frequency range of five to a few hundred Hertz. The widest bandwidth was achieved with force at the shaker/fixture interface with SWAT corrections and from the voltage and current measurements.

  19. Fuzzy efficiency optimization of AC induction motors

    NASA Technical Reports Server (NTRS)

    Jani, Yashvant; Sousa, Gilberto; Turner, Wayne; Spiegel, Ron; Chappell, Jeff

    1993-01-01

    This paper describes the early states of work to implement a fuzzy logic controller to optimize the efficiency of AC induction motor/adjustable speed drive (ASD) systems running at less than optimal speed and torque conditions. In this paper, the process by which the membership functions of the controller were tuned is discussed and a controller which operates on frequency as well as voltage is proposed. The membership functions for this dual-variable controller are sketched. Additional topics include an approach for fuzzy logic to motor current control which can be used with vector-controlled drives. Incorporation of a fuzzy controller as an application-specific integrated circuit (ASIC) microchip is planned.

  20. Camshaft driving system for internal combustion engine

    SciTech Connect

    Hiroshima, K.A.

    1987-06-23

    This patent describes camshaft driving system for a double overhead camshaft engine cylinder rows extend parallel to the crankshaft of the engine. The second cylinder row is rearwardly displaced from the first cylinder row in the axial direction of the crankshaft so that vacant spaces are formed respectively behind the first cylinder row and in front of the second cylinder row. All the pistons in the cylinders of the first and second cylinder rows are connected to the crankshaft and a pair of camshafts for driving the intake and exhaust valves are provided in the cylinder head of each cylinder row to extend in the direction of the crankshaft. The camshaft driving system comprises a timing pulley provided on one of the intake and exhaust camshafts of each cylinder row to rotate together with the camshaft; A crank pulley is driven by the crankshaft; A first driving force transmission means transmits rotation of the crank pulley to the timing pulleys of the first and second cylinder rows; a second driving force transmission means transmits rotation of the timing pulley of the first cylinder row to the other of the camshafts of the first cylinder row; and a third driving force transmission means transmits rotation of the timing pulley of the second cylinder row to the other of the camshafts of the second cylinder row. The second driving force transmission means is disposed in the vacant space behind the first cylinder row and the third driving force transmission means is disposed in the vacant space in front of the second cylinder row.

  1. Extended Driving Impairs Nocturnal Driving Performances

    PubMed Central

    Sagaspe, Patricia; Taillard, Jacques; Åkerstedt, Torbjorn; Bayon, Virginie; Espié, Stéphane; Chaumet, Guillaume; Bioulac, Bernard; Philip, Pierre

    2008-01-01

    Though fatigue and sleepiness at the wheel are well-known risk factors for traffic accidents, many drivers combine extended driving and sleep deprivation. Fatigue-related accidents occur mainly at night but there is no experimental data available to determine if the duration of prior driving affects driving performance at night. Participants drove in 3 nocturnal driving sessions (3–5am, 1–5am and 9pm–5am) on open highway. Fourteen young healthy men (mean age [±SD] = 23.4 [±1.7] years) participated Inappropriate line crossings (ILC) in the last hour of driving of each session, sleep variables, self-perceived fatigue and sleepiness were measured. Compared to the short (3–5am) driving session, the incidence rate ratio of inappropriate line crossings increased by 2.6 (95% CI, 1.1 to 6.0; P<.05) for the intermediate (1–5am) driving session and by 4.0 (CI, 1.7 to 9.4; P<.001) for the long (9pm–5am) driving session. Compared to the reference session (9–10pm), the incidence rate ratio of inappropriate line crossings were 6.0 (95% CI, 2.3 to 15.5; P<.001), 15.4 (CI, 4.6 to 51.5; P<.001) and 24.3 (CI, 7.4 to 79.5; P<.001), respectively, for the three different durations of driving. Self-rated fatigue and sleepiness scores were both positively correlated to driving impairment in the intermediate and long duration sessions (P<.05) and increased significantly during the nocturnal driving sessions compared to the reference session (P<.01). At night, extended driving impairs driving performances and therefore should be limited. PMID:18941525

  2. AC/RF Superconductivity

    SciTech Connect

    Ciovati, Gianluigi

    2015-02-01

    This contribution provides a brief introduction to AC/RF superconductivity, with an emphasis on application to accelerators. The topics covered include the surface impedance of normal conductors and superconductors, the residual resistance, the field dependence of the surface resistance, and the superheating field.

  3. AC solar cell

    SciTech Connect

    Schutten, H.P.; Benjamin, J.A.; Lade, R.W.

    1986-03-18

    An AC solar cell is described comprising: a pair of PN junction type solar cells connected in antiparallel between a pair of main terminals; and means for electrically directing light alternatingly without mechanical movement on the PN junctions to generate an alternating potential across the main terminals.

  4. AC 67 Launch Video

    NASA Technical Reports Server (NTRS)

    1987-01-01

    Live footage of the Unmanned Atlas Centaur (AC) 67 launch is presented on March 26, 1987 at the WESH television station in Florida. Lightning is shown after 49 seconds into the flight. The vehicle is totally destroyed due to a cloud-to-ground lightning flash.

  5. Electrical drive for automobile

    SciTech Connect

    Fobbs, H.

    1980-09-16

    Electrical apparatus for driving an automobile is described that is comprised of a dc motor operationally connected to the rear axle through a drive shaft with the motor energized from storage batteries and recharged from alternators coupled to the drive shaft adjacent a clutch at the rear end of the automobile through an auxiliary drive shaft.

  6. Coaxial Redundant Drives

    NASA Technical Reports Server (NTRS)

    Brissette, R.

    1983-01-01

    Harmonic drives allow redundancy and high out put torque in small package. If main drive fails, standby drive takes over and produces torque along same axis as main drive. Uses include power units in robot for internal pipeline inspection, manipulators in deep submersible probes or other applications in which redundancy protects against costly failures.

  7. Dynamics and control of instrumented harmonic drives

    NASA Technical Reports Server (NTRS)

    Kazerooni, H.; Ellis, S. R. (Principal Investigator)

    1995-01-01

    Since torque in harmonic drives is transmitted by a pure couple, harmonic drives do not generate radial forces and therefore can be instrumented with torque sensors without interference from radial forces. The installation of torque sensors on the stationary component of harmonic drives (the Flexipline cup in this research work) produce backdrivability needed for robotic and telerobotic compliant maneuvers. Backdrivability of a harmonic drive, when used as torque increaser, means that the output shaft can be rotated via finite amount of torque. A high ratio harmonic drive is non-backdrivable because its output shaft cannot be turned by applying a torque on it. This article first develops the dynamic behavior of a harmonic drive, in particular the non-backdrivability, in terms of a sensitivity transfer function. The instrumentation of the harmonic drive with torque sensor is then described. This leads to a description of the control architecture which allows modulation of the sensitivity transfer function within the limits established by the closed-loop stability. A set of experiments on an active hand controller, powered by a DC motor coupled to an instrumented harmonic drive, is given to exhibit this method's limitations.

  8. Solar array drive system

    NASA Technical Reports Server (NTRS)

    Berkopec, F. D.; Sturman, J. C.; Stanhouse, R. W.

    1976-01-01

    A solar array drive system consisting of a solar array drive mechanism and the corresponding solar array drive electronics is being developed. The principal feature of the solar array drive mechanism is its bidirectional capability which enables its use in mechanical redundancy. The solar array drive system is of a widely applicable design. This configuration will be tested to determine its acceptability for generic mission sets. Foremost of the testing to be performed is the testing for extended duration.

  9. Thin Shell evolution of NIF capsule with asymmetric drive and the resulting neutron diagnostics

    NASA Astrophysics Data System (ADS)

    Buchoff, Michael; Hammer, Jim

    2015-11-01

    One of the major impediments to achieving ignition via ICF is the non-spherical implosion arising from small asymmetries in the drive forcing the collapse of the capsule. Likewise, an experimental diagnostic for quantifying the characteristics of the implosion asymmetry is the final state neutrons, whose number and velocity distributions are not experimentally consistent with the expectation of a spherical implosion. In principle, connecting these initial and final state asymmetries could be solved via hydrodynamic simulations, but due to the multiple scales traversed throughout this process, these calculations are difficult and expensive, leaving much of the potential drive asymmetry profiles unexplored. In this work, we solve the resulting analytic equations from the thin-shell model proposed by Ott et. al. to evolve the capsule over a range of different drive asymmetries from its initial state (when the shell aspect ratio is much greater than 1) to a radius of roughly 250 microns, consisting of a layer of dense CH, a cold layer of dense DT, and a warm core of sparsely distributed DT. At this stage, more tractable hydrodynamical simulations are performed in the ARES code suite, determining the distribution of neutron from thermonuclear yield. These and future results allow for a multitude of tests of asymmetric sources to compare with and potentially guide experiment. This work was performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344.

  10. Interplay between electron overheating and ac Josephson effect

    NASA Astrophysics Data System (ADS)

    De Cecco, A.; Le Calvez, K.; Sacépé, B.; Winkelmann, C. B.; Courtois, H.

    2016-05-01

    We study the response of high-critical-current proximity Josephson junctions to a microwave excitation. Electron overheating in such devices is known to create hysteretic dc voltage-current characteristics. Here we demonstrate that it also strongly influences the ac response. The interplay of electron overheating and ac Josephson dynamics is revealed by the evolution of the Shapiro steps with the microwave drive amplitude. Extending the resistively shunted Josephson junction model by including a thermal balance for the electronic bath coupled to phonons, a strong electron overheating is obtained.

  11. The ac propulsion system for an electric vehicle, phase 1

    NASA Technical Reports Server (NTRS)

    Geppert, S.

    1981-01-01

    A functional prototype of an electric vehicle ac propulsion system was built consisting of a 18.65 kW rated ac induction traction motor, pulse width modulated (PWM) transistorized inverter, two speed mechanically shifted automatic transmission, and an overall drive/vehicle controller. Design developmental steps, and test results of individual components and the complex system on an instrumented test frame are described. Computer models were developed for the inverter, motor and a representative vehicle. A preliminary reliability model and failure modes effects analysis are given.

  12. EXT-II: a second generation advanced ac propulsion system

    SciTech Connect

    Bates, B.; Patil, P.B.; Ciccarelli, M.F.

    1986-01-01

    This paper discusses the characteristics of the concept and includes discussion of the system constraints, including traction battery constraints, and brief descriptions of the major subsystems being developed. The components discussed include: the system controller, dc to ac inverter, an internal permanent magnet ac motor and a two-speed automatic transmission with an integral final drive and differential. The motor and transmission are on a common axis and are integrated into one compact unit that is integral with the rear axle of the vehicle.

  13. AC power systems handbook

    SciTech Connect

    Whitaker, J.

    1991-01-01

    Transient disturbances are what headaches are made of. Whatever you call them-spikes, surges, are power bumps-they can take your equipment down and leave you with a complicated and expensive repair job. Protection against transient disturbances is a science that demands attention to detail. This book explains how the power distribution system works, what can go wrong with it, and how to protect a facility against abnormalities. system grounding and shielding are covered in detail. Each major method of transient protection is analyzed and its relative merits discussed. The book provides a complete look at the critical elements of the ac power system. Provides a complete look at the ac power system from generation to consumption. Discusses the mechanisms that produce transient disturbances and how to protect against them. Presents diagrams to facilitate system design. Covers new areas, such as the extent of the transient disturbance problem, transient protection options, and stand-by power systems.

  14. Wind-powered asynchronous AC/DC/AC converter system. [for electric power supply regulation

    NASA Technical Reports Server (NTRS)

    Reitan, D. K.

    1973-01-01

    Two asynchronous ac/dc/ac systems are modelled that utilize wind power to drive a variable or constant hertz alternator. The first system employs a high power 60-hertz inverter tie to the large backup supply of the power company to either supplement them from wind energy, storage, or from a combination of both at a preset desired current; rectifier and inverter are identical and operate in either mode depending on the silicon control rectifier firing angle. The second system employs the same rectification but from a 60-hertz alternator arrangement; it provides mainly dc output, some sinusoidal 60-hertz from the wind bus and some high harmonic content 60-hertz from an 800-watt inverter.

  15. Control rod drive for reactor shutdown

    DOEpatents

    McKeehan, Ernest R.; Shawver, Bruce M.; Schiro, Donald J.; Taft, William E.

    1976-01-20

    A means for rapidly shutting down or scramming a nuclear reactor, such as a liquid metal-cooled fast breeder reactor, and serves as a backup to the primary shutdown system. The control rod drive consists basically of an in-core assembly, a drive shaft and seal assembly, and a control drive mechanism. The control rod is driven into the core region of the reactor by gravity and hydraulic pressure forces supplied by the reactor coolant, thus assuring that common mode failures will not interfere with or prohibit scramming the reactor when necessary.

  16. Development of a 10 kW High Temperature High Power Density Three-Phase AC-DC-AC SiC Converter

    SciTech Connect

    Ning, Puqi

    2012-01-01

    This paper presents the development and experimental performance of a 10 kW, all SiC, 250 C junction temperature high-power-density three-phase ac-dc-ac converter. The electromagnetic interference filter, thermal system, high temperature package, and gate drive design are discussed in detail. Finally, tests confirming the feasibility and validating the theoretical basis of the prototype converter system are described.

  17. Alternating-Current Motor Drive for Electric Vehicles

    NASA Technical Reports Server (NTRS)

    Krauthamer, S.; Rippel, W. E.

    1982-01-01

    New electric drive controls speed of a polyphase as motor by varying frequency of inverter output. Closed-loop current-sensing circuit automatically adjusts frequency of voltage-controlled oscillator that controls inverter frequency, to limit starting and accelerating surges. Efficient inverter and ac motor would give electric vehicles extra miles per battery charge.

  18. Driving and neurodegenerative diseases.

    PubMed

    Uc, Ergun Y; Rizzo, Matthew

    2008-09-01

    The proportion of elderly people in the general population is rising, resulting in greater numbers of drivers with neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease. These neurodegenerative disorders impair cognition, visual perception, and motor function, leading to reduced driver fitness and greater crash risk. Yet neither medical diagnosis nor age alone is reliable enough to predict driver safety or crashes or to revoke the driving privileges of these individuals. Driving research utilizes tools such as questionnaires about driving habits and history, driving simulators, standardized road tests utilizing instrumented vehicles, and state driving records. Research challenges include outlining the evolution of driving safety, understanding the mechanisms of driving impairment, and developing a reliable and efficient standardized test battery for prediction of driver safety in neurodegenerative disorders. This information will enable healthcare providers to advise their patients with neurodegenerative disorders with more certainty, affect policy, and help develop rehabilitative measures for driving. PMID:18713573

  19. Gear bearing drive

    NASA Technical Reports Server (NTRS)

    Weinberg, Brian (Inventor); Mavroidis, Constantinos (Inventor); Vranish, John M. (Inventor)

    2011-01-01

    A gear bearing drive provides a compact mechanism that operates as an actuator providing torque and as a joint providing support. The drive includes a gear arrangement integrating an external rotor DC motor within a sun gear. Locking surfaces maintain the components of the drive in alignment and provide support for axial loads and moments. The gear bearing drive has a variety of applications, including as a joint in robotic arms and prosthetic limbs.

  20. Combination spindle-drive system for high precision machining

    DOEpatents

    Gerth, Howard L.

    1977-07-26

    A combination spindle-drive is provided for fabrication of optical quality surface finishes. Both the spindle-and-drive utilize the spindle bearings for support, thereby removing the conventional drive-means bearings as a source of vibration. An airbearing spindle is modified to carry at the drive end a highly conductive cup-shaped rotor which is aligned with a stationary stator to produce torque in the cup-shaped rotor through the reaction of eddy currents induced in the rotor. This arrangement eliminates magnetic attraction forces and all force is in the form of torque on the cup-shaped rotor.

  1. Circuit for Driving Piezoelectric Transducers

    NASA Technical Reports Server (NTRS)

    Randall, David P.; Chapsky, Jacob

    2009-01-01

    The figure schematically depicts an oscillator circuit for driving a piezoelectric transducer to excite vibrations in a mechanical structure. The circuit was designed and built to satisfy application-specific requirements to drive a selected one of 16 such transducers at a regulated amplitude and frequency chosen to optimize the amount of work performed by the transducer and to compensate for both (1) temporal variations of the resonance frequency and damping time of each transducer and (2) initially unknown differences among the resonance frequencies and damping times of different transducers. In other words, the circuit is designed to adjust itself to optimize the performance of whichever transducer is selected at any given time. The basic design concept may be adaptable to other applications that involve the use of piezoelectric transducers in ultrasonic cleaners and other apparatuses in which high-frequency mechanical drives are utilized. This circuit includes three resistor-capacitor networks that, together with the selected piezoelectric transducer, constitute a band-pass filter having a peak response at a frequency of about 2 kHz, which is approximately the resonance frequency of the piezoelectric transducers. Gain for generating oscillations is provided by a power hybrid operational amplifier (U1). A junction field-effect transistor (Q1) in combination with a resistor (R4) is used as a voltage-variable resistor to control the magnitude of the oscillation. The voltage-variable resistor is part of a feedback control loop: Part of the output of the oscillator is rectified and filtered for use as a slow negative feedback to the gate of Q1 to keep the output amplitude constant. The response of this control loop is much slower than 2 kHz and, therefore, does not introduce significant distortion of the oscillator output, which is a fairly clean sine wave. The positive AC feedback needed to sustain oscillations is derived from sampling the current through the

  2. Magnetic drive coupling

    NASA Technical Reports Server (NTRS)

    Carter, Edward L. (Inventor)

    1987-01-01

    The driving and driven members of a magnetic drive are separated by en enlarged gap to provide clearance for a conduit or other member. Flux pins in the gap maintain the torque transmitting capability of the drive. The spacing between two of the flux pins is increased to provide space for the conduit.

  3. Magnetic drive coupling

    NASA Technical Reports Server (NTRS)

    Carter, Edward L. (Inventor)

    1989-01-01

    The driving (30) and driven (32) members of a magnetic drive (20) are separated by an enlarged gap (35) to provide clearance for a conduit (23) or other member. Flux pins (40) in the gap (35) maintain the torque transmitting capability of the drive (20). The spacing between two of the flux pins is increased to provide space for the conduit (23).

  4. Sequential Dependencies in Driving

    ERIC Educational Resources Information Center

    Doshi, Anup; Tran, Cuong; Wilder, Matthew H.; Mozer, Michael C.; Trivedi, Mohan M.

    2012-01-01

    The effect of recent experience on current behavior has been studied extensively in simple laboratory tasks. We explore the nature of sequential effects in the more naturalistic setting of automobile driving. Driving is a safety-critical task in which delayed response times may have severe consequences. Using a realistic driving simulator, we find…

  5. Grieving while Driving

    ERIC Educational Resources Information Center

    Rosenblatt, Paul C.

    2004-01-01

    Secondary analysis of data from 84 people in 2 interview studies shows that some bereaved people grieve actively while driving. The grief can be intense, even years after a death. Grief while driving may erupt spontaneously or be set off by a wide range of reminders. Some bereaved people seem to save their grieving for times when they drive,…

  6. Electric versus hydraulic drives

    SciTech Connect

    Not Available

    1983-01-01

    This volume records the proceedings of a conference organised by the Engineering Manufacturing Industries Division of the Institution of Mechanical Engineers. Topics considered include high performance position control - a review of the current state of developments; hydrostatic drives - present and future; electric drives - present and future trends; electrical and hydraulic drives for heavy industrial robots; the development of an electro-mechanical tilt system for the advanced passenger train; industrial hydraulic ring mains - effective or efficient. the comparison of performance of servo feed-drive systems; overhead crane drives; the future of d.c. servodrives; the choice of actuator for military systems; linear electro-hydraulic actuators; and actuation for industrial robots.

  7. Blocked force measurement of an electro-active paper actuator using a cantilevered force transducer

    NASA Astrophysics Data System (ADS)

    Yun, Gyu-young; Kim, Heung Soo; Kim, Jaehwan

    2008-04-01

    The blocked force of an electro-active paper (EAPap) actuator was measured by a custom-built force transducer. The tip deflection of the force transducer was measured and converted into force using a simple Euler beam model. Since the blocked force is the maximum force generated at the tip of a bending actuator without displacement, the blocked force was found from the measured force of the transducer by extrapolating it. The force transducer was made from a thin steel cantilever beam and calibrated using a linear stage and a micro-balance. The measured maximum free bending displacement of the EAPap actuator was 4.4 mm and the blocked force was 224 µN under 350 V mm-1 AC electric field and 33 µN under DC electric field with the same field strength. When an AC electric field was applied to the actuator, the generated blocked force of the EAPap was about 700% larger than that caused by DC excitation. The proposed blocked force measurement is accurate down to a micro-Newton resolution under DC as well as AC electric fields.

  8. Identification of /sup 233/Ac

    SciTech Connect

    Chu, Y.Y.; Zhou, M.L.

    1983-09-01

    We report in this paper identification of the new isotope /sup 233/Ac. Uranium targets were irradiated with 28 GeV protons; after rapid retrieval of the target and separation of actinium from thorium, /sup 233/Ac was allowed to decay into the known /sup 233/Th daughter. Exhaustive chemical purification was employed to permit the identification of /sup 233/Th via its characteristic ..gamma.. radiations. The half-life derived for /sup 233/Ac from several experiments is 2.3 +- 0.3 min. The production cross section for /sup 233/Ac is 100 ..mu..b.

  9. AC resistance measuring instrument

    DOEpatents

    Hof, P.J.

    1983-10-04

    An auto-ranging AC resistance measuring instrument for remote measurement of the resistance of an electrical device or circuit connected to the instrument includes a signal generator which generates an AC excitation signal for application to a load, including the device and the transmission line, a monitoring circuit which provides a digitally encoded signal representing the voltage across the load, and a microprocessor which operates under program control to provide an auto-ranging function by which range resistance is connected in circuit with the load to limit the load voltage to an acceptable range for the instrument, and an auto-compensating function by which compensating capacitance is connected in shunt with the range resistance to compensate for the effects of line capacitance. After the auto-ranging and auto-compensation functions are complete, the microprocessor calculates the resistance of the load from the selected range resistance, the excitation signal, and the load voltage signal, and displays of the measured resistance on a digital display of the instrument. 8 figs.

  10. AC Resistance measuring instrument

    DOEpatents

    Hof, Peter J.

    1983-01-01

    An auto-ranging AC resistance measuring instrument for remote measurement of the resistance of an electrical device or circuit connected to the instrument includes a signal generator which generates an AC excitation signal for application to a load, including the device and the transmission line, a monitoring circuit which provides a digitally encoded signal representing the voltage across the load, and a microprocessor which operates under program control to provide an auto-ranging function by which range resistance is connected in circuit with the load to limit the load voltage to an acceptable range for the instrument, and an auto-compensating function by which compensating capacitance is connected in shunt with the range resistance to compensate for the effects of line capacitance. After the auto-ranging and auto-compensation functions are complete, the microprocessor calculates the resistance of the load from the selected range resistance, the excitation signal, and the load voltage signal, and displays of the measured resistance on a digital display of the instrument.

  11. Prediction and analysis of variable reluctance stepmotor drive systems

    NASA Astrophysics Data System (ADS)

    Pulle, D. W. J.

    1982-01-01

    A relationship between the electric terminal parameters and output/input power is derived for conventional doubly-salient synchronous machines and extended to include the variable reluctance motor. The advantages and limitations of the drive-schemes are shown in Blondel diagrams and torque speed curves. A general method for obtaining a quantitative assessment of drive-schemes is developed by the introduction of so-called performance figures, related to the output power and efficiency. From this method applied to four drive schemes, it is concluded that severe performance degradation is the result of using a forging resistance in a drive-scheme. A forced decay unipolar chopper drive is presented.

  12. Drill drive mechanism

    DOEpatents

    Dressel, Michael O.

    1979-01-01

    A drill drive mechanism is especially adapted to provide both rotational drive and axial feed for a drill of substantial diameter such as may be used for drilling holes for roof bolts in mine shafts. The drill shaft is made with a helical pattern of scroll-like projections on its surface for removal of cuttings. The drill drive mechanism includes a plurality of sprockets carrying two chains of drive links which are arranged to interlock around the drill shaft with each drive link having depressions which mate with the scroll-like projections. As the chain links move upwardly or downwardly the surfaces of the depressions in the links mate with the scroll projections to move the shaft axially. Tangs on the drive links mate with notch surfaces between scroll projections to provide a means for rotating the shaft. Projections on the drive links mate together at the center to hold the drive links tightly around the drill shaft. The entire chain drive mechanism is rotated around the drill shaft axis by means of a hydraulic motor and gear drive to cause rotation of the drill shaft. This gear drive also connects with a differential gearset which is interconnected with a second gear. A second motor is connected to the spider shaft of the differential gearset to produce differential movement (speeds) at the output gears of the differential gearset. This differential in speed is utilized to drive said second gear at a speed different from the speed of said gear drive, this speed differential being utilized to drive said sprockets for axial movement of said drill shaft.

  13. AC Zeeman potentials for atom chip-based ultracold atoms

    NASA Astrophysics Data System (ADS)

    Fancher, Charles; Pyle, Andrew; Ziltz, Austin; Aubin, Seth

    2015-05-01

    We present experimental and theoretical progress on using the AC Zeeman force produced by microwave magnetic near-fields from an atom chip to manipulate and eventually trap ultracold atoms. These AC Zeeman potentials are inherently spin-dependent and can be used to apply qualitatively different potentials to different spin states simultaneously. Furthermore, AC Zeeman traps are compatible with the large DC magnetic fields necessary for accessing Feshbach resonances. Applications include spin-dependent trapped atom interferometry and experiments in 1D many-body physics. Initial experiments and results are geared towards observing the bipolar detuning-dependent nature of the AC Zeeman force at 6.8 GHz with ultracold 87Rb atoms trapped in the vicinity of an atom chip. Experimental work is also underway towards working with potassium isotopes at frequencies of 1 GHz and below. Theoretical work is focused on atom chip designs for AC Zeeman traps produced by magnetic near-fields, while also incorporating the effect of the related electric near-fields. Electromagnetic simulations of atom chip circuits are used for mapping microwave propagation in on-chip transmission line structures, accounting for the skin effect, and guiding impedance matching.

  14. Stepper motor drive for on load tapchanger in electric locomotive

    SciTech Connect

    Aruna Kumar, G.V.D.; Kumar, S.; Mishra, P.; Wadhonkar, N.K.

    1995-12-31

    Indian Railways have a fleet of 2,200 electrical locomotives running on 25 KV ac traction. An on-load tap changer is used to select voltage for speed control of dc traction motor. A four stroke reciprocating type air motor is used presently to drive the tap changer (GR). Complex gear and camshaft mechanism is used to move tap changer and to generate various logic signals for safe loco operation. The annual failure rate for tap changer and its drive is of the order of 20%. A microprocessor controlled stepper motor drive has been designed and constructed to drive the on-load tap changer. A current controlled chopper is used to drive the motor and control logic has been generated through an optimum hardware and software combination. The assembly has been tested on a prototype tap changer in the laboratory.

  15. Proposal of Current Control Method for High-Speed AC Motor System

    NASA Astrophysics Data System (ADS)

    Furutani, Shinichi; Satake, Akira

    In this paper, current control method for High-Speed AC Motor System is proposed. In High-Speed driving operation, Current controller tends to lose stability because of dead time caused by computational delay and Electromagnetic coupling included AC Motor Model. The Main purpose of the proposed method is reduction of dead time on current controller. Proposed method based model predictive control and optimizing of start timing. The Effectiveness of proposed method is confirmed by simulation results.

  16. AC propulsion system for an electric vehicle, phase 2

    NASA Technical Reports Server (NTRS)

    Slicker, J. M.

    1983-01-01

    A second-generation prototype ac propulsion system for a passenger electric vehicle was designed, fabricated, tested, installed in a modified Mercury Lynx vehicle and track tested at the Contractor's site. The system consisted of a Phase 2, 18.7 kw rated ac induction traction motor, a 192-volt, battery powered, pulse-width-modulated, transistorized inverter packaged for under rear seat installation, a 2-axis, 2-speed, automatically-shifted mechanical transaxle and a microprocessor-based powertrain/vehicle controller. A diagnostics computer to assist tuning and fault finding was fabricated. Dc-to-mechanical-system efficiency varied from 78% to 82% as axle speed/torque ranged from 159 rpm/788 nm to 65 rpm/328 nm. Track test efficiency results suggest that the ac system will be equal or superior to dc systems when driving urban cycles. Additional short-term work is being performed under a third contract phase (AC-3) to raise transaxle efficiency to predicted levels, and to improve starting and shifting characteristics. However, the long-term challenge to the system's viability remains inverter cost. A final report on the Phase 2 system, describing Phase 3 modifications, will be issued at the conclusion of AC-3.

  17. AC propulsion system for an electric vehicle, phase 2

    NASA Astrophysics Data System (ADS)

    Slicker, J. M.

    1983-06-01

    A second-generation prototype ac propulsion system for a passenger electric vehicle was designed, fabricated, tested, installed in a modified Mercury Lynx vehicle and track tested at the Contractor's site. The system consisted of a Phase 2, 18.7 kw rated ac induction traction motor, a 192-volt, battery powered, pulse-width-modulated, transistorized inverter packaged for under rear seat installation, a 2-axis, 2-speed, automatically-shifted mechanical transaxle and a microprocessor-based powertrain/vehicle controller. A diagnostics computer to assist tuning and fault finding was fabricated. Dc-to-mechanical-system efficiency varied from 78% to 82% as axle speed/torque ranged from 159 rpm/788 nm to 65 rpm/328 nm. Track test efficiency results suggest that the ac system will be equal or superior to dc systems when driving urban cycles. Additional short-term work is being performed under a third contract phase (AC-3) to raise transaxle efficiency to predicted levels, and to improve starting and shifting characteristics. However, the long-term challenge to the system's viability remains inverter cost. A final report on the Phase 2 system, describing Phase 3 modifications, will be issued at the conclusion of AC-3.

  18. Cooling Floor AC Systems

    NASA Astrophysics Data System (ADS)

    Jun, Lu; Hao, Ding; Hong, Zhang; Ce, Gao Dian

    The present HVAC equipments for the residential buildings in the Hot-summer-and-Cold-winter climate region are still at a high energy consuming level. So that the high efficiency HVAC system is an urgently need for achieving the preset government energy saving goal. With its advantage of highly sanitary, highly comfortable and uniform of temperature field, the hot-water resource floor radiation heating system has been widely accepted. This paper has put forward a new way in air-conditioning, which combines the fresh-air supply unit and such floor radiation system for the dehumidification and cooling in summer or heating in winter. By analyze its advantages and limitations, we found that this so called Cooling/ Heating Floor AC System can improve the IAQ of residential building while keep high efficiency quality. We also recommend a methodology for the HVAC system designing, which will ensure the reduction of energy cost of users.

  19. Digital ac monitor

    DOEpatents

    Hart, George W.; Kern, Jr., Edward C.

    1987-06-09

    An apparatus and method is provided for monitoring a plurality of analog ac circuits by sampling the voltage and current waveform in each circuit at predetermined intervals, converting the analog current and voltage samples to digital format, storing the digitized current and voltage samples and using the stored digitized current and voltage samples to calculate a variety of electrical parameters; some of which are derived from the stored samples. The non-derived quantities are repeatedly calculated and stored over many separate cycles then averaged. The derived quantities are then calculated at the end of an averaging period. This produces a more accurate reading, especially when averaging over a period in which the power varies over a wide dynamic range. Frequency is measured by timing three cycles of the voltage waveform using the upward zero crossover point as a starting point for a digital timer.

  20. Thermionic triode generates ac power

    NASA Technical Reports Server (NTRS)

    Kniazzeh, A. G. F.; Scharz, F. C.

    1970-01-01

    Electrostatic grid controls conduction cycle of thermionic diode to convert low dc output voltages to high ac power without undesirable power loss. An ac voltage applied to the grid of this new thermionic triode enables it to convert heat directly into high voltage electrical power.

  1. Automated ac galvanomagnetic measurement system

    NASA Technical Reports Server (NTRS)

    Szofran, F. R.; Espy, P. N.

    1985-01-01

    An automated, ac galvanomagnetic measurement system is described. Hall or van der Pauw measurements in the temperature range 10-300 K can be made at a preselected magnetic field without operator attendance. Procedures to validate sample installation and correct operation of other system functions, such as magnetic field and thermometry, are included. Advantages of ac measurements are discussed.

  2. 15. TYPE H, BUILDING #321451 BREENE DRIVE, INTERIOR, FIRST FLOOR, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    15. TYPE H, BUILDING #321-451 BREENE DRIVE, INTERIOR, FIRST FLOOR, LIVING ROOM, SOUTHEAST VIEW. - Wright-Patterson Air Force Base, Brick Officers' Quarters, Types G & H, Area A, Dayton, Montgomery County, OH

  3. 16. TYPE H, BUILDING #321451 BREENE DRIVE, INTERIOR, SECOND FLOOR, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    16. TYPE H, BUILDING #321-451 BREENE DRIVE, INTERIOR, SECOND FLOOR, HALLWAY, BEDROOM AND HALLWAY, NORTH VIEW. - Wright-Patterson Air Force Base, Brick Officers' Quarters, Types G & H, Area A, Dayton, Montgomery County, OH

  4. 14. TYPE H, BUILDING #321451 BREENE DRIVE, INTERIOR, FIRST FLOOR, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    14. TYPE H, BUILDING #321-451 BREENE DRIVE, INTERIOR, FIRST FLOOR, LIVING ROOM, EAST VIEW. - Wright-Patterson Air Force Base, Brick Officers' Quarters, Types G & H, Area A, Dayton, Montgomery County, OH

  5. 17. View of Mercury Avenue from Apollo Drive, looking north ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    17. View of Mercury Avenue from Apollo Drive, looking north at E-wing - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

  6. 15. Threequarter view of Gwing from intersection of Apollo Drive ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    15. Three-quarter view of G-wing from intersection of Apollo Drive and Mercury Avenue, looking northwest - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

  7. Phonon-Induced Electron-Hole Excitation and ac Conductance in Molecular Junction

    NASA Astrophysics Data System (ADS)

    Ueda, Akiko; Utsumi, Yasuhiro; Imamura, Hiroshi; Tokura, Yasuhiro

    2016-04-01

    We investigate the linear ac conductance of molecular junctions under a fixed dc bias voltage in the presence of an interaction between a transporting electron and a single local phonon in a molecule with energy ω0. The electron-phonon interaction is treated by the perturbation expansion. The ac conductance as a function of the ac frequency ωac decreases or increases compared with the noninteracting case depending on the magnitude of the dc bias voltage. Furthermore, a dip emerges at ωac ˜ 2ω0. The dip originates from the modification of electron-hole excitation by the ac field, which cannot be obtained by treating the phonon in the linear regime of a classical forced oscillation.

  8. Improved transistorized AC motor controller for battery powered urban electric passenger vehicles

    NASA Technical Reports Server (NTRS)

    Peak, S. C.

    1982-01-01

    An ac motor controller for an induction motor electric vehicle drive system was designed, fabricated, tested, evaluated, and cost analyzed. A vehicle performance analysis was done to establish the vehicle tractive effort-speed requirements. These requirements were then converted into a set of ac motor and ac controller requirements. The power inverter is a three-phase bridge using power Darlington transistors. The induction motor was optimized for use with an inverter power source. The drive system has a constant torque output to base motor speed and a constant horsepower output to maximum speed. A gear shifting transmission is not required. The ac controller was scaled from the base 20 hp (41 hp peak) at 108 volts dec to an expanded horsepower and battery voltage range. Motor reversal was accomplished by electronic reversal of the inverter phase sequence. The ac controller can also be used as a boost chopper battery charger. The drive system was tested on a dynamometer and results are presented. The current-controlled pulse width modulation control scheme yielded improved motor current waveforms. The ac controller favors a higher system voltage.

  9. Superluminal warp drive

    NASA Astrophysics Data System (ADS)

    González-Díaz, Pedro F.

    2007-09-01

    In this Letter we consider a warp drive spacetime resulting from that suggested by Alcubierre when the spaceship can only travel faster than light. Restricting to the two dimensions that retains most of the physics, we derive the thermodynamic properties of the warp drive and show that the temperature of the spaceship rises up as its apparent velocity increases. We also find that the warp drive spacetime can be exhibited in a manifestly cosmological form.

  10. Aligned Immobilization of Proteins Using AC Electric Fields.

    PubMed

    Laux, Eva-Maria; Knigge, Xenia; Bier, Frank F; Wenger, Christian; Hölzel, Ralph

    2016-03-01

    Protein molecules are aligned and immobilized from solution by AC electric fields. In a single-step experiment, the enhanced green fluorescent proteins are immobilized on the surface as well as at the edges of planar nanoelectrodes. Alignment is found to follow the molecules' geometrical shape with their longitudinal axes parallel to the electric field. Simultaneous dielectrophoretic attraction and AC electroosmotic flow are identified as the dominant forces causing protein movement and alignment. Molecular orientation is determined by fluorescence microscopy based on polarized excitation of the proteins' chromophores. The chromophores' orientation with respect to the whole molecule supports X-ray crystal data. PMID:26779699

  11. Sensing mode atomic force microscope

    DOEpatents

    Hough, Paul V. C.; Wang, Chengpu

    2003-01-01

    An atomic force microscope utilizes a pulse release system and improved method of operation to minimize contact forces between a probe tip affixed to a flexible cantilever and a specimen being measured. The pulse release system includes a magnetic particle affixed proximate the probe tip and an electromagnetic coil. When energized, the electromagnetic coil generates a magnetic field which applies a driving force on the magnetic particle sufficient to overcome adhesive forces exhibited between the probe tip and specimen. The atomic force microscope includes two independently displaceable piezo elements operable along a Z-axis. A controller drives the first Z-axis piezo element to provide a controlled approach between the probe tip and specimen up to a point of contact between the probe tip and specimen. The controller then drives the first Z-axis piezo element to withdraw the cantilever from the specimen. The controller also activates the pulse release system which drives the probe tip away from the specimen during withdrawal. Following withdrawal, the controller adjusts the height of the second Z-axis piezo element to maintain a substantially constant approach distance between successive samples.

  12. Diabetes and driving.

    PubMed

    Inkster, B; Frier, B M

    2013-09-01

    The principal safety concern for driving for people treated with insulin or insulin secretagogues is hypoglycaemia, which impairs driving performance. Other complications, such as those causing visual impairment and peripheral neuropathy, are also relevant to medical fitness to drive. Case control studies have suggested that drivers with diabetes pose a modestly increased but acceptable and measurable risk of motor vehicle accidents compared to non-diabetic drivers, but many studies are limited and of poor quality. Factors which have been shown to increase driving risk include previous episodes of severe hypoglycaemia, previous hypoglycaemia while driving, strict glycaemic control (lower HbA1c) and absence of blood glucose monitoring before driving. Impaired awareness of hypoglycaemia may be counteracted by frequent blood glucose testing. The European Union Third directive on driving (2006) has necessitated changes in statutory regulations for driving licences for people with diabetes in all European States, including the UK. Stricter criteria have been introduced for Group 1 vehicle licences while those for Group 2 licences have been relaxed. Insulin-treated drivers can now apply to drive Group 2 vehicles, but in the UK must meet very strict criteria and be assessed by an independent specialist to be issued with a 1-year licence. PMID:23350766

  13. Dielectrophoretic Force Imaging of Biological Systems

    NASA Astrophysics Data System (ADS)

    Simpson, Garth J.

    2004-03-01

    A new scanning probe microscopic technique is demonstrated, exploiting AC electrokinetic forces for real-time functional imaging of biological interfaces with nanometer-scale spatial resolution. Dielectrophoresis (DEP) describes the mobility of particles in radio-frequency AC electric fields and is related to the frequency-dependent polarizability. Similar to the forces in optical trapping, DEP interactions are greatest for large field gradients, such as those adjacent to highly curved electrodes. Moderate AC potentials (5 Vpp) are more than sufficient to induce surface forces strong enough for reliable feedback during imaging. Simply changing the AC frequency can change the nature of the DEP force from repulsive to attractive. By scanning the AC frequency, dielectrophoretic spectroscopy using light with a wavelength of ˜ 1/2 km can be performed with spatial resolution of a few nanometers (about 11 to 12 orders of magnitude below the diffraction-limit), representing a new level of achievement in near-field microscopy. Among other things, the facile applicability of DEP imaging in aqueous media is ideally suited for ultrahigh resolution microscopy of biological systems, including supported lipid bilayer membranes, immobilized organelles, and living cells.

  14. Proceedings of the international conference on maglev and linear drives

    SciTech Connect

    Not Available

    1986-01-01

    This book contains papers presented at a conference on Maglev and linear drives. Topics covered include: Development of superconducting magnets for the Canadian electrodynamic Maglev vehicle; Power supply system to drive HSST - Expo '86; and Thrust and levitation force characteristics of linear synchronous motors.

  15. Characterization and snubbing of a bidirectional MCT in a resonant ac link converter

    NASA Technical Reports Server (NTRS)

    Lee, Tony; Elbuluk, Malik E.; Zinger, Donald S.

    1993-01-01

    The MOS-Controlled Thyristor (MCT) is emerging as a powerful switch that combines the better characteristics of existing power devices. A study of switching stresses on an MCT switch under zero voltage resonant switching is presented. The MCT is used as a bidirectional switch in an ac/ac pulse density modulated inverter for induction motor drive. Current and voltage spikes are observed and analyzed with variations in the timing of the switching. Different snubber circuit configurations are under investigation to minimize the effect of these transients. The results will be extended to study and test the MCT switching in a medium power (5 hp) induction motor drive.

  16. Nuclear forces

    SciTech Connect

    Machleidt, R.

    2013-06-10

    These lectures present an introduction into the theory of nuclear forces. We focus mainly on the modern approach, in which the forces between nucleons emerge from low-energy QCD via chiral effective field theory.

  17. Reading Text While Driving

    PubMed Central

    Horrey, William J.; Hoffman, Joshua D.

    2015-01-01

    Objective In this study, we investigated how drivers adapt secondary-task initiation and time-sharing behavior when faced with fluctuating driving demands. Background Reading text while driving is particularly detrimental; however, in real-world driving, drivers actively decide when to perform the task. Method In a test track experiment, participants were free to decide when to read messages while driving along a straight road consisting of an area with increased driving demands (demand zone) followed by an area with low demands. A message was made available shortly before the vehicle entered the demand zone. We manipulated the type of driving demands (baseline, narrow lane, pace clock, combined), message format (no message, paragraph, parsed), and the distance from the demand zone when the message was available (near, far). Results In all conditions, drivers started reading messages (drivers’ first glance to the display) before entering or before leaving the demand zone but tended to wait longer when faced with increased driving demands. While reading messages, drivers looked more or less off road, depending on types of driving demands. Conclusions For task initiation, drivers avoid transitions from low to high demands; however, they are not discouraged when driving demands are already elevated. Drivers adjust time-sharing behavior according to driving demands while performing secondary tasks. Nonetheless, such adjustment may be less effective when total demands are high. Application This study helps us to understand a driver’s role as an active controller in the context of distracted driving and provides insights for developing distraction interventions. PMID:25850162

  18. Labor Force

    ERIC Educational Resources Information Center

    Occupational Outlook Quarterly, 2012

    2012-01-01

    The labor force is the number of people ages 16 or older who are either working or looking for work. It does not include active-duty military personnel or the institutionalized population, such as prison inmates. Determining the size of the labor force is a way of determining how big the economy can get. The size of the labor force depends on two…

  19. Laterally self-oscillated and force-balanced microvibratory gyroscope packaged in a vacuum package with a conditioning ASIC

    NASA Astrophysics Data System (ADS)

    Park, Kyu-Yeon; Lee, Chong-Won; Oh, Yong-Soo; Lee, Byeungleul

    1997-11-01

    A novel concept self-oscillator and dynamically tunable micro vibratory gyroscope, where oscillating, position- sensing and force-balancing take place on the wafer surface, has been developed. The gyroscope consists of: a grid-type planar mass which oscillates on the wafer surface; pairs of the differential capacitor type with LT shape position sense electrodes; a pair of force-balancing electrodes; oppositely placed comb-drive and comb-sensor for mass self-oscillation; fish hook shape springs to match the first and second modes with the mass oscillating and position sensing modes, respectively. The natural frequency of the position sensing mode is lowered and tuned by the DC bias voltage applied to the position sense electrodes and then finely tuned by DC bias on a pair of force-balancing electrodes. To reduce the mass exciting along the sensing direction, we drive the mass by the same DC and opposite AC driving voltage on the oppositely placed comb-drives. It also features that the position sensing electric interference ins reduced. The mass is self-oscillated by the condition of limit cycle, so the mass is always oscillated in the natural frequency even if the natural frequency is varied by the environment and/or it has displacement-force nonlinear behavior. The gyroscope is fabricated on the silicon wafer by surface micromachining technology and the polysilicon is used as an active structure. The gyroscope has an active size of 700 by 600 micro meters, the thickness of the structure is 7 micron meters and the proof mass of 1 micro gram. To improve the resolution of the gyro, it is packaged in the 50 mili-torr vacuum package with a conditioning ASIC. Experimental results show that the gyroscope has the equivalent noise level of 0.1 deg/sec at 2 Hz, the bandwidth of 100 Hz, linearity of 1 percent FS and the sensing range of 90 deg/sec.

  20. Operation Method for AC Motor Control during Power Interruption in Direct AC/AC Converter System

    NASA Astrophysics Data System (ADS)

    Shizu, Keiichiro; Azuma, Satoshi

    Direct AC/AC converters have been studied due to their potential use in power converters with no DC-link capacitor, which can contribute to the miniaturization of power converters. However, the absence of a DC-link capacitor makes it difficult to control the AC motor during power interruption. First, this paper proposes a system that realizes AC motor control during power interruption by utilizing a clamp capacitor. In general, direct AC/AC converters have a clamp circuit consisting of a rectifier diode(s) and a clamp capacitor in order to avoid over-voltages. In the proposed system, there is an additional semiconductor switch reverse-parallel to the rectifier diode(s), and the clamp capacitor voltage can be utilized for AC motor control by turning on the additional switch. Second, this paper discusses an operation method for AC motor control and clamp capacitor voltage control during power interruption. In the proposed method “DC-link voltage control”, the kinetic energy in the AC motor is transformed into electrical energy and stored in the clamp capacitor; the clamp capacitor is therefore charged and the capacitor voltage is controlled to remain constant at an instruction value. Third, this paper discusses a switching operation during power interruption. A dead-time is introduced between the operation of turning off all switches on the rectifier side and the operation of turning on the additional switch, which prevents the occurrence of a short circuit between the interrupted power source and the clamp capacitor. Finally, experimental results are presented. During power interruptions, an output current was continuously obtained and the clamp capacitor voltage was maintained to be equal to the instruction value of the capacitor voltage. These results indicate that both AC motor control and capacitor voltage control were successfully achieved by using the proposed system.

  1. Multilevel converters for large electric drives

    SciTech Connect

    Tolbert, L.M.; Peng, F.Z.

    1997-11-01

    Traditional two-level high frequency pulse width modulation (PWM) inverters for motor drives have several problems associated with their high frequency switching which produces common-mode voltage and high voltage change (dV/dt) rates to the motor windings. Multilevel inverters solve these problems because their devices can switch at a much lower frequency. Two different multilevel topologies are identified for use as a converter for electric drives, a cascade inverter with separate dc sources and a back-to-back diode clamped converter. The cascade inverter is a natural fit for large automotive all electric drives because of the high VA ratings possible and because it uses several levels of dc voltage sources which would be available from batteries or fuel cells. The back to back diode damped converter is ideal where a source of ac voltage is available such as a hybrid electric vehicle. Simulation and experimental results show the superiority of these two converters over PWM based drives.

  2. Piezoelectric drive circuit

    DOEpatents

    Treu, C.A. Jr.

    1999-08-31

    A piezoelectric motor drive circuit is provided which utilizes the piezoelectric elements as oscillators and a Meacham half-bridge approach to develop feedback from the motor ground circuit to produce a signal to drive amplifiers to power the motor. The circuit automatically compensates for shifts in harmonic frequency of the piezoelectric elements due to pressure and temperature changes. 7 figs.

  3. Piezoelectric drive circuit

    DOEpatents

    Treu, Jr., Charles A.

    1999-08-31

    A piezoelectric motor drive circuit is provided which utilizes the piezoelectric elements as oscillators and a Meacham half-bridge approach to develop feedback from the motor ground circuit to produce a signal to drive amplifiers to power the motor. The circuit automatically compensates for shifts in harmonic frequency of the piezoelectric elements due to pressure and temperature changes.

  4. Dual drive actuators

    NASA Technical Reports Server (NTRS)

    Packard, D. T.

    1982-01-01

    A new class of electromechanical actuators is described. These dual drive actuators were developed for the NASA-JPL Galileo Spacecraft. The dual drive actuators are fully redundant and therefore have high inherent reliability. They can be used for a variety of tasks, and they can be fabricated quickly and economically.

  5. Design of traction drives

    NASA Technical Reports Server (NTRS)

    Loewenthal, S. H.; Zaretsky, E. V.

    1985-01-01

    Traction drives are among the simplest of all speed-changing mechanisms. Because of their simplicity and their ability to smoothly and continuously adjust speed, they are excellent choices for many drive system applications. They have been used in industrial service for more than 100 years. Today's traction drives have power capacities which rival the best gear and belt drives due to modern traction fluids and highly fatigue-resistant bearing steels. This report summarizes methods to analyze and size traction drives. Lubrication principles, contact kinematics, stress, fatigue life, and performance prediction methods are presented. The effects of the lubricant's traction characteristics on life and power loss are discussed. An example problem is given which illustrates the effects of spin on power loss. Loading mechanism design and the design of nonlubricated friction wheels and rings are also treated.

  6. AC photovoltaic module magnetic fields

    SciTech Connect

    Jennings, C.; Chang, G.J.; Reyes, A.B.; Whitaker, C.M.

    1997-12-31

    Implementation of alternating current (AC) photovoltaic (PV) modules, particularly for distributed applications such as PV rooftops and facades, may be slowed by public concern about electric and magnetic fields (EMF). This paper documents magnetic field measurements on an AC PV module, complementing EMF research on direct-current PV modules conducted by PG and E in 1993. Although not comprehensive, the PV EMF data indicate that 60 Hz magnetic fields (the EMF type of greatest public concern) from PV modules are comparable to, or significantly less than, those from household appliances. Given the present EMF research knowledge, AC PV module EMF may not merit considerable concern.

  7. A friction regulation hybrid driving method for backward motion restraint of the smooth impact drive mechanism

    NASA Astrophysics Data System (ADS)

    Wang, Liang; Chen, Dong; Cheng, Tinghai; He, Pu; Lu, Xiaohui; Zhao, Hongwei

    2016-08-01

    The smooth impact drive mechanism (SIDM) is a type of piezoelectric actuator that has been developed for several decades. As a kind of driving method for the SIDM, the traditional sawtooth (TS) wave is always employed. The kinetic friction force during the rapid contraction stage usually results in the generation of a backward motion. A friction regulation hybrid (FRH) driving method realized by a composite waveform for the backward motion restraint of the SIDM is proposed in this paper. The composite waveform is composed of a sawtooth driving (SD) wave and a sinusoidal friction regulation (SFR) wave which is applied to the rapid deformation stage of the SD wave. A prototype of the SIDM was fabricated and its output performance under the excitation of the FRH driving method and the TS wave driving method was tested. The results indicate that the backward motion can be restrained obviously using the FRH driving method. Compared with the driving effect of the TS wave, the backward rates of the prototype in forward and reverse motions are decreased by 83% and 85%, respectively.

  8. Tuning of peptide assembly through force balance adjustment.

    PubMed

    Cao, Meiwen; Cao, Changhai; Zhang, Lijuan; Xia, Daohong; Xu, Hai

    2013-10-01

    Controlled self-assembly of amphiphilic tripeptides into distinct nanostructures is achieved via a controlled design of the molecular architecture. The tripeptide Ac-Phe-Phe-Lys-CONH2 (FFK), hardly soluble in water, forms long amyloid-like tubular structures with the aid of β-sheet hydrogen bonding and aromatic π-π stacking. Substitution of phenylalanine (F) with tyrosine (Y), that is, only a subtle structural variation in adding a hydroxyl group to the phenyl ring, results in great change in molecular self-assembly behavior. When one F is substituted with Y, the resulting molecules of FYK and YFK self-assemble into long thinner fibrils with high propensity for lateral association. When both Fs are substituted with Y, the resulting YYK molecule forms spherical aggregates. Introduction of hydroxyl groups into the molecule modifies aromatic interactions and introduces hydrogen bonding. Moreover, since the driving forces for peptide self-assembly including hydrogen bonding, electrostatic repulsion, and π-π stacking have high interdependence with each other, changes in aromatic interaction induce a Domino effect and cause a shift of force balance to a new state. This leads to significant variations in self-assembly behavior. PMID:23871602

  9. Magnetic drive system for a new centrifugal rotary blood pump.

    PubMed

    Hilton, Andrew; Tansley, Geoff

    2008-10-01

    The purpose of this investigation was to design a novel magnetic drive and bearing system for a new centrifugal rotary blood pump (CRBP). The drive system consists of two components: (i) permanent magnets within the impeller of the CRBP; and (ii) the driving electromagnets. Orientation of the magnets varies from axial through to 60 degrees included out-lean (conical configuration). Permanent magnets replace the electromagnet drive to allow easier characterization. The performance characteristics tested were the axial force of attraction between the stator and rotor at angles of rotational alignment, Ø, and the corresponding torque at those angles. The drive components were tested for various magnetic cone angles, theta. The test was repeated for three backing conditions: (i) non-backed; (ii) steel-cupped; and (iii) steel plate back-iron, performed on an Instron tensile testing machine. Experimental results were expanded upon through finite element and boundary element analysis (BEM). The force/torque characteristics were maximal for a 12-magnet configuration at 0 degree cone angle with steel-back iron (axial force = 60 N, torque = 0.375 Nm). BEM showed how introducing a cone angle increases the radial restoring force threefold while not compromising axial bearing force. Magnets in the drive system may be orientated not only to provide adequate coupling to drive the CRBP, but to provide significant axial and radial bearing forces capable of withstanding over 100 m/s(2) shock excitation on the impeller. Although the 12 magnet 0 degree (theta) configuration yielded the greatest force/torque characteristic, this was seen as potentially unattractive as this magnetic cone angle yielded poor radial restoring force characteristics. PMID:18959665

  10. Ac traction gets on track

    SciTech Connect

    O`Connor, L.

    1995-09-01

    This article describes inverter-based ac traction systems which give freight locomotives greater adhesion, pulling power, and braking capacity. In the 1940s, dc traction replaced the steam engine as a source of train propulsion, and it has ruled the freight transportation industry ever since. But now, high-performance ac-traction systems, with their unprecedented levels of pulling power and adhesion, are becoming increasingly common on America`s freight railroads. In thousands of miles of demonstration tests, today`s ac-traction systems have outperformed traditional dc-motor driven systems. Major railroad companies are convinced enough of the benefits of ac traction to have integrated it into their freight locomotives.

  11. Vision and Driving

    PubMed Central

    Owsley, Cynthia; McGwin, Gerald

    2010-01-01

    Driving is the primary means of personal travel in many countries and is relies heavily on vision for its successful execution. Research over the past few decades has addressed the role of vision in driver safety (motor vehicle collision involvement) and in driver performance (both on-road and using interactive simulators in the laboratory). Here we critically review what is currently known about the role of various aspects of visual function in driving. We also discuss translational research issues on vision screening for licensure and re-licensure and rehabilitation of visually impaired persons who want to drive. PMID:20580907

  12. Redundant motor drive system

    NASA Technical Reports Server (NTRS)

    Calvert, J. A. (Inventor)

    1980-01-01

    A drive system characterized by a base supporting a pair of pillars arranged in spaced parallelism, a shaft extended between and supported by the pillars for rotation about the longitudinal axis thereof, a worm gear affixed to the shaft and supported in coaxial relation therewith is described. A bearing housing of a sleeve like configuration is concentrically related to the shaft and is supported thereby for free rotation. A first and a second quiescent drive train, alternatively activatable, is provided for imparting rotation into said bearing housing. Each of the drive trains is characterized by a selectively energizable motor connected to a spur gear.

  13. The Test Drive

    NASA Technical Reports Server (NTRS)

    2004-01-01

    This image taken at NASA's Jet Propulsion Laboratory shows engineers rehearsing the sol 133 (June 8, 2004) drive into 'Endurance' crater by NASA's Mars Exploration Rover Opportunity. Engineers and scientists have recreated the martian surface and slope the rover will encounter using a combination of bare and thinly sand-coated rocks, simulated martian 'blueberries' and a platform tilted at a 25-degree angle. The results of this test convinced engineers that the rover was capable of driving up and down a straight slope before it attempted the actual drive on Mars.

  14. Assessment of US electric vehicle programs with ac powertrains

    SciTech Connect

    Kevala, R.J. . Transportation Consulting Div.)

    1990-02-01

    AC powertrain technology is a promising approach to improving the performance of electric vehicles. Four major programs are now under way in the United States to develop ac powertrains: the Ford/General Electric single-shaft electric propulsion system (ETX-II), the Eaton dual-shaft electric propulsion system (DSEP), the Jet Propulsion Laboratories (JPL) integrated ac motor drive and recharge system, and the Massachusetts Institute of Technology (MIT) variable reluctance motor (VRM) drive. The JPL program is sponsored by EPRI; the other three programs are funded by the US Department of Energy. This preliminary assessment of the four powertrain programs focuses on potential performance, costs, safety, and commercial feasibility. Interviews with program personnel were supplemented by computer simulations of electric vehicle performance using the four systems. Each of the four powertrains appears superior to standard dc powertrain technology in terms of performance and weight. The powertrain technologies studied in this assessment are at varying degrees of technological maturity. One or more of the systems may be ready for incorporation into an advanced electric vehicle during the early 1990s. Each individual report will have a separate abstract. 5 refs., 37 figs., 29 tabs.

  15. A fluctuation theorem for non-equilibrium relaxational systems driven by external forces

    NASA Astrophysics Data System (ADS)

    Zamponi, Francesco; Bonetto, Federico; Cugliandolo, Leticia F.; Kurchan, Jorge

    2005-09-01

    We discuss an extension of the fluctuation theorem to stochastic models that, in the limit of zero external drive, are not able to equilibrate with their environment, extending earlier results of Sellitto. We show that if the entropy production rate is suitably defined, its probability distribution function verifies the fluctuation relation with the ambient temperature replaced by a (frequency dependent) effective temperature. We derive modified Green-Kubo relations. We illustrate these results with the simple example of an oscillator coupled to a non-equilibrium bath driven by an external force. We discuss the relevance of our results for driven glasses and the diffusion of Brownian particles in out-of-equilibrium media and propose a concrete experimental strategy for measuring the low frequency value of the effective temperature using the fluctuations of the work done by an ac conservative field. We compare our results to related ones that appeared in the literature recently.

  16. Dementia and driving

    MedlinePlus

    ... getting more dangerous include: Getting lost on familiar roads Reacting more slowly in traffic Driving too slowly ... attention to traffic signs Taking chances on the road Drifting into other lanes Getting more agitated in ...

  17. Drive program documentation

    NASA Technical Reports Server (NTRS)

    Graham, S.

    1979-01-01

    The program description and user's guide for the Downlist Requirement Integrated Verification and Evaluation (DRIVE) program is provided. The program is used to compare existing telemetry downlist files with updated downlist requirements.

  18. Safe driving for teens

    MedlinePlus

    ... drivers. Do not use cell phones for talking, texting, or email when you are driving. Mobile phones ... pull off of the road before answering or texting. Other tips include: Avoid putting on makeup while ...

  19. Labs drive the arms race

    SciTech Connect

    DeWitt, H.E.

    1984-11-01

    The conviction of laboratory managers that high technology can provide safety and national security in a dangerous world and that technological solutions are paramount over political solutions has been a major driving force in perpetuating the nuclear arms race. The credo in the laboratories appears to be that there are never enough designs of nuclear weapons for deterrence so that there is always a need to develop such new ideas as the nuclear-pumped X-ray laser as a defense against energy missiles. The author outlines several alternative steps, including the ratification and reaffirmation of arms control treaties, negotiations, and a halt to the Star Wars program. A central point is to stop nuclear weapons testing. 7 references.

  20. Direct drive wind turbine

    DOEpatents

    Bywaters, Garrett Lee; Danforth, William; Bevington, Christopher; Stowell, Jesse; Costin, Daniel

    2006-09-19

    A wind turbine is provided that minimizes the size of the drive train and nacelle while maintaining the power electronics and transformer at the top of the tower. The turbine includes a direct drive generator having an integrated disk brake positioned radially inside the stator while minimizing the potential for contamination. The turbine further includes a means for mounting a transformer below the nacelle within the tower.

  1. Direct drive wind turbine

    DOEpatents

    Bywaters, Garrett; Danforth, William; Bevington, Christopher; Jesse, Stowell; Costin, Daniel

    2007-02-27

    A wind turbine is provided that minimizes the size of the drive train and nacelle while maintaining the power electronics and transformer at the top of the tower. The turbine includes a direct drive generator having an integrated disk brake positioned radially inside the stator while minimizing the potential for contamination. The turbine further includes a means for mounting a transformer below the nacelle within the tower.

  2. Direct drive wind turbine

    DOEpatents

    Bywaters, Garrett; Danforth, William; Bevington, Christopher; Stowell, Jesse; Costin, Daniel

    2006-07-11

    A wind turbine is provided that minimizes the size of the drive train and nacelle while maintaining the power electronics and transformer at the top of the tower. The turbine includes a direct drive generator having an integrated disk brake positioned radially inside the stator while minimizing the potential for contamination. The turbine further includes a means for mounting a transformer below the nacelle within the tower.

  3. Direct drive wind turbine

    DOEpatents

    Bywaters, Garrett; Danforth, William; Bevington, Christopher; Jesse, Stowell; Costin, Daniel

    2006-10-10

    A wind turbine is provided that minimizes the size of the drive train and nacelle while maintaining the power electronics and transformer at the top of the tower. The turbine includes a direct drive generator having an integrated disk brake positioned radially inside the stator while minimizing the potential for contamination. The turbine further includes a means for mounting a transformer below the nacelle within the tower.

  4. Self-driving carsickness.

    PubMed

    Diels, Cyriel; Bos, Jelte E

    2016-03-01

    This paper discusses the predicted increase in the occurrence and severity of motion sickness in self-driving cars. Self-driving cars have the potential to lead to significant benefits. From the driver's perspective, the direct benefits of this technology are considered increased comfort and productivity. However, we here show that the envisaged scenarios all lead to an increased risk of motion sickness. As such, the benefits this technology is assumed to bring may not be capitalised on, in particular by those already susceptible to motion sickness. This can negatively affect user acceptance and uptake and, in turn, limit the potential socioeconomic benefits that this emerging technology may provide. Following a discussion on the causes of motion sickness in the context of self-driving cars, we present guidelines to steer the design and development of automated vehicle technologies. The aim is to limit or avoid the impact of motion sickness and ultimately promote the uptake of self-driving cars. Attention is also given to less well known consequences of motion sickness, in particular negative aftereffects such as postural instability, and detrimental effects on task performance and how this may impact the use and design of self-driving cars. We conclude that basic perceptual mechanisms need to be considered in the design process whereby self-driving cars cannot simply be thought of as living rooms, offices, or entertainment venues on wheels. PMID:26446454

  5. Parkinson disease and driving

    PubMed Central

    Classen, Sherrilene; Uc, Ergun Y.

    2012-01-01

    ABSTRACT The growing literature on driving in Parkinson disease (PD) has shown that driving is impaired in PD compared to healthy comparison drivers. PD is a complex neurodegenerative disorder leading to motor, cognitive, and visual impairments, all of which can affect fitness to drive. In this review, we examined studies of driving performance (on-road tests and simulators) in PD for outcome measures and their predictors. We searched through various databases and found 25 (of 99) primary studies, all published in English. Using the American Academy of Neurology criteria, a study class of evidence was assigned (I–IV, I indicating the highest level of evidence) and recommendations were made (Level A: predictive or not; B: probably predictive or not; C: possibly predictive or not; U: no recommendations). From available Class II and III studies, we identified various cognitive, visual, and motor measures that met different levels of evidence (usually Level B or C) with respect to predicting on-road and simulated driving performance. Class I studies reporting Level A recommendations for definitive predictors of driving performance in drivers with PD are needed by policy makers and clinicians to develop evidence-based guidelines. PMID:23150533

  6. Modeling of ac dielectric barrier discharge

    SciTech Connect

    Shang, J. S.; Huang, P. G.

    2010-06-15

    The qualitative electrodynamic field of the dielectric barrier discharge in air is studied by a three-component, drift-diffusion plasma model including the Poisson equation of plasmadynamics. The critical media interface boundary conditions independent of the detailed mechanisms of surface absorption, diffusion, recombination, and charge accumulation on electrode or dielectrics are developed from the theory of electromagnetics. The computational simulation duplicates the self-limiting feature of dielectric barrier discharge for preventing corona-to-spark transition, and the numerical results of the breakdown voltage are compared very well with data. According to the present modeling, the periodic electrodynamic force due to charge separation over the electrodes also exerts on alternative directions from the exposed to encapsulated electrodes over a complete ac cycle as experimental observations.

  7. Hydraulic drive system prevents backlash

    NASA Technical Reports Server (NTRS)

    Acord, J. D.

    1965-01-01

    Hydraulic drive system uses a second drive motor operating at reduced torque. This exerts a relative braking action which eliminates the normal gear train backlash that is intolerable when driving certain heavy loads.

  8. Family Influences and Unconscious Drives.

    ERIC Educational Resources Information Center

    English, Fanita

    2001-01-01

    Drives for survival, expression, and quiescence influence early human development and continue to influence career development throughout life. Turmoil may arise when a drive conflicts with others or is suppressed by other drives. (SK)

  9. Driving platform for OLED lighting investigations

    NASA Astrophysics Data System (ADS)

    Vogel, Uwe; Elgner, Andreas; Kreye, Daniel; Amelung, Jörg; Scholles, Michael

    2006-08-01

    OLED technology may be excellently suitable for lighting applications by combining high efficiency, cost effective manufacturing and the use of low cost materials. Certain issues remain to be solved so far, including OLED brightness, color, lifetime, large area uniformity and encapsulation. Another aspect, that might be capable in addressing some of the mentioned issues, is OLED lighting electrical driving. We report on the design of a driving platform for OLED lighting test panels or substrates. It is intended for being a test environment for lighting substrates as well as demonstration/presentation environment. It is based on a 128-channel passive-matrix driver/controller ASIC OC2. Its key component is an MSP430-compatible 16-bit micro-controller core including embedded Flash memory (program), EEPROM (parameter), and RAM (data memory). A significant feature of the device is an electronic approach for improving the lifetime/uniformity behavior of connected OLED. The embedded micro-controller is the key to the high versatility of OC2, since by firmware modification it can be adapted to various applications and conditions. Here its application for an OLED lighting driving platform is presented. Major features of this platform are PC-control mode (via USB interface), stand-alone mode (no external control necessary, just power supply), on-board OLED panel parameter storage, flat geometry of OLED lighting panel carrier (board), AC and DC driving regimes, adjustable reverse voltage, dedicated user SW (PC/Windows-based), sub-tile patterning and single sub-tile control, combination of multiple channels for increasing driving current. This publication contains results of the project "High Brightness OLEDs for ICT & Next Generation Lighting Applications" (OLLA), funded by the European Commission.

  10. Labor Force

    ERIC Educational Resources Information Center

    Occupational Outlook Quarterly, 2010

    2010-01-01

    The labor force is the number of people aged 16 or older who are either working or looking for work. It does not include active-duty military personnel or institutionalized people, such as prison inmates. Quantifying this total supply of labor is a way of determining how big the economy can get. Labor force participation rates vary significantly…

  11. One Force

    NASA Astrophysics Data System (ADS)

    Kotas, Ronald R.

    2002-04-01

    There is only one entity that can extend force and couple through space; and it should be apparent that Electromagnetism is that entity. In the cases of the nuclear strong force and the nuclear weak force, this is the same fundamental Electromagnetism manifesting itself in two different ways in the nucleus. It remains the same basic Electromagnetism. On the other hand, General Relativity fails to produce force at a distance, fails the Cavendish experiment, and does not allow an apple to fall to the ground. The result shows there is only Electromagnetism that functions through physical nature providing gravity, actions in the nucleus, as well as all other physical actions universally, including Gravity and Gravitation. There are many direct proofs of this, the same proofs as in NUCLEAR QUANTUM GRAVITATION. In contrast, General Relativity plainly relies on fallacy abstract and incoherent proofs; proofs which have now been mostly disproved. In the past it was deemed necessary by some to have an "ether" to propagate Electromagnetic waves. The fallacy concept of time space needs "space distortions" in order to cause gravity. However, Electromagnetic gravity does not have this problem. Clearly there is only ONE FORCE that causes Gravity, Electromagnetism, the Nuclear Strong Force, and the Nuclear Weak Force, and that ONE FORCE is Electromagnetism.

  12. Modulating Brain Oscillations to Drive Brain Function

    PubMed Central

    Thut, Gregor

    2014-01-01

    Do neuronal oscillations play a causal role in brain function? In a study in this issue of PLOS Biology, Helfrich and colleagues address this long-standing question by attempting to drive brain oscillations using transcranial electrical current stimulation. Remarkably, they were able to manipulate visual perception by forcing brain oscillations of the left and right visual hemispheres into synchrony using oscillatory currents over both hemispheres. Under this condition, human observers more often perceived an inherently ambiguous visual stimulus in one of its perceptual instantiations. These findings shed light on the mechanisms underlying neuronal computation. They show that it is the neuronal oscillations that drive the visual experience, not the experience driving the oscillations. And they indicate that synchronized oscillatory activity groups brain areas into functional networks. This points to new ways for controlled experimental and possibly also clinical interventions for the study and modulation of brain oscillations and associated functions. PMID:25549340

  13. Friction drive characterization breadboard: test results

    NASA Astrophysics Data System (ADS)

    Sedghi, B.; Lucuix, C.; Tortolani, J. M.; Brunetto, E.; Delrez, C.; Gabriel, E.

    2010-07-01

    The drive and bearing technologies have a major impact on the static and dynamic performance of steerable structures such as telescope and dome. Merging drive and bearing system into friction drive mechanical devices (bogie) can reduce the complexity and cost of the design. In the framework of ELT design study (European FP6) a breadboard test setup was realized to test and evaluate the static and dynamic behavior of such bogies. In this paper some of the characterization test results are presented. Characterization of the bogies and the setup structure in the frequency domain, quantification and measure of the most important parameters of the friction forces, the control of the bogies and the tracking performance of the test setup are among the main results discussed in this paper.

  14. Quantum recurrence and fractional dynamic localization in ac-driven perfect state transfer Hamiltonians

    SciTech Connect

    Longhi, Stefano

    2014-06-15

    Quantum recurrence and dynamic localization are investigated in a class of ac-driven tight-binding Hamiltonians, the Krawtchouk quantum chain, which in the undriven case provides a paradigmatic Hamiltonian model that realizes perfect quantum state transfer and mirror inversion. The equivalence between the ac-driven single-particle Krawtchouk Hamiltonian H{sup -hat} (t) and the non-interacting ac-driven bosonic junction Hamiltonian enables to determine in a closed form the quasi energy spectrum of H{sup -hat} (t) and the conditions for exact wave packet reconstruction (dynamic localization). In particular, we show that quantum recurrence, which is predicted by the general quantum recurrence theorem, is exact for the Krawtchouk quantum chain in a dense range of the driving amplitude. Exact quantum recurrence provides perfect wave packet reconstruction at a frequency which is fractional than the driving frequency, a phenomenon that can be referred to as fractional dynamic localization.

  15. Kelvin Probe Force Microscopy by Dissipative Electrostatic Force Modulation

    NASA Astrophysics Data System (ADS)

    Miyahara, Yoichi; Topple, Jessica; Schumacher, Zeno; Grutter, Peter

    2015-11-01

    We report an experimental technique for Kelvin probe force microscopy using the dissipation signal of frequency-modulation atomic force microscopy for bias-voltage feedback. It features a simple implementation and faster scanning as it requires no low-frequency modulation. The dissipation is caused by the oscillating electrostatic force that is coherent with the tip oscillation, which is induced by a sinusoidally oscillating voltage applied between the tip and sample. We analyze the effect of the phase of the oscillating force on the frequency shift and dissipation and found that the relative phase of 90° that causes only the dissipation is the most appropriate for Kelvin-probe-force-microscopy measurements. The present technique requires a significantly smaller ac-voltage amplitude by virtue of enhanced force detection due to the resonance enhancement and the use of fundamental flexural-mode oscillation for electrostatic force detection. This feature will be of great importance in the electrical characterizations of technically relevant materials whose electrical properties are influenced by the externally applied electric field as is the case in semiconductor electronic devices.

  16. Base drive for paralleled inverter systems

    NASA Technical Reports Server (NTRS)

    Nagano, S. (Inventor)

    1980-01-01

    In a paralleled inverter system, a positive feedback current derived from the total current from all of the modules of the inverter system is applied to the base drive of each of the power transistors of all modules, thereby to provide all modules protection against open or short circuit faults occurring in any of the modules, and force equal current sharing among the modules during turn on of the power transistors.

  17. Modeling of Passive Forces of Machine Tool Covers

    NASA Astrophysics Data System (ADS)

    Kolar, Petr; Hudec, Jan; Sulitka, Matej

    The passive forces acting against the drive force are phenomena that influence dynamical properties and precision of linear axes equipped with feed drives. Covers are one of important sources of passive forces in machine tools. The paper describes virtual evaluation of cover passive forces using the cover complex model. The model is able to compute interaction between flexible cover segments and sealing wiper. The result is deformation of cover segments and wipers which is used together with measured friction coefficient for computation of cover total passive force. This resulting passive force is dependent on cover position. Comparison of computational results and measurement on the real cover is presented in the paper.

  18. Improved linear ultrasonic motor performance with square-wave based driving-tip trajectory

    NASA Astrophysics Data System (ADS)

    Le, Adam Y.; Mills, James K.; Benhabib, Beno

    2015-03-01

    This paper proposes the application of a non-sinusoidal periodic excitation voltage to induce a near-square-wave driving tip trajectory in linear ultrasonic motors (LUSMs). A square-wave-based trajectory can deliver superior frictional force to the moving stage in the forward stroke of the driving tip motion and reduced frictional force during the return stroke. This would reduce lost power in the periodic driving tip motion, thereby, increasing the output force and power of the LUSM. An implementation procedure is suggested to achieve the near-square-wave driving tip trajectory. The proposed approach is illustrated through realistic finite-element-based simulations using a bimodal LUSM configuration.

  19. Mental workload and driving

    PubMed Central

    Paxion, Julie; Galy, Edith; Berthelon, Catherine

    2014-01-01

    The aim of this review is to identify the most representative measures of subjective and objective mental workload in driving, and to understand how the subjective and objective levels of mental workload influence the performance as a function of situation complexity and driving experience, i.e., to verify whether the increase of situation complexity and the lack of experience increase the subjective and physiological levels of mental workload and lead to driving performance impairments. This review will be useful to both researchers designing an experimental study of mental workload and to designers of drivers’ training content. In the first part, we will broach the theoretical approach with two factors of mental workload and performance, i.e., situation complexity and driving experience. Indeed, a low complex situation (e.g., highways), or conversely a high complex situation (e.g., town) can provoke an overload. Additionally, performing the driving tasks implies producing a high effort for novice drivers who have not totally automated the driving activity. In the second part, we will focus on subjective measures of mental workload. A comparison of questionnaires usually used in driving will allow identifying the most appropriate ones as a function of different criteria. Moreover, we will review the empirical studies to verify if the subjective level of mental workload is high in simple and very complex situations, especially for novice drivers compared to the experienced ones. In the third part, we will focus on physiological measures. A comparison of physiological indicators will be realized in order to identify the most correlated to mental workload. An empirical review will also take the effect of situation complexity and experience on these physiological indicators into consideration. Finally, a more nuanced comparison between subjective and physiological measures will be established from the impact on situation complexity and experience. PMID:25520678

  20. Force sensor

    DOEpatents

    Grahn, Allen R.

    1993-01-01

    A force sensor and related method for determining force components. The force sensor includes a deformable medium having a contact surface against which a force can be applied, a signal generator for generating signals that travel through the deformable medium to the contact surface, a signal receptor for receiving the signal reflected from the contact surface, a generation controller, a reception controller, and a force determination apparatus. The signal generator has one or more signal generation regions for generating the signals. The generation controller selects and activates the signal generation regions. The signal receptor has one or more signal reception regions for receiving signals and for generating detections signals in response thereto. The reception controller selects signal reception regions and detects the detection signals. The force determination apparatus measures signal transit time by timing activation and detection and, optionally, determines force components for selected cross-field intersections. The timer which times by activation and detection can be any means for measuring signal transit time. A cross-field intersection is defined by the overlap of a signal generation region and a signal reception region.