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Sample records for acad sci issn

  1. Energy data base. Serial titles with ISSN listing

    SciTech Connect

    Hendricks, P.L.

    1984-03-01

    This issue of Serial Titles with ISSN Listing is the first revision of DOE/TIC-4579 to include the International Standard Serial Number (ISSN) for journals. The TIC journal authority was established to bring about conformity in citing the approximately 16,000 titles contained in this authority. It can prove to be a valuable tool in establishing the precise journal by ISSN and CODEN indication, especially for journals with the same title published in different locations. Serial Titles with ISSN Listing is comprised of two parts. Part 1 is an alphabetical listing by full title of the publication and also includes abbreviated title, CODEN, ISSN, coverage code, and country code. Part 2 is an ISSN-title correlation arranged in numeric order by ISSN and also includes the CODEN and full title.

  2. ISSN Exercise & Sport Nutrition Review: Research & Recommendations

    PubMed Central

    Kreider, Richard B; Almada, Anthony L; Antonio, Jose; Broeder, Craig; Earnest, Conrad; Greenwood, Mike; Incledon, Thomas; Kalman, Douglas S; Kleiner, Susan M; Leutholtz, Brian; Lowery, Lonnie M; Mendel, Ron; Stout, Jeffrey R; Willoughby, Darryn S; Ziegenfuss, Tim N

    2004-01-01

    Sport nutrition is a constantly evolving field with literally thousands of research papers published annually. For this reason, keeping up to date with the literature is often difficult. This paper presents a well-referenced overview of the current state of the science related to how to optimize training through nutrition. More specifically, this article discusses: 1.) how to evaluate the scientific merit of nutritional supplements; 2.) general nutritional strategies to optimize performance and enhance recovery; and, 3.) our current understanding of the available science behind weight gain, weight loss, and performance enhancement supplements. Our hope is that ISSN members find this review useful in their daily practice and consultation with their clients.

  3. ISSN exercise & sport nutrition review: research & recommendations

    PubMed Central

    2010-01-01

    Sports nutrition is a constantly evolving field with hundreds of research papers published annually. For this reason, keeping up to date with the literature is often difficult. This paper is a five year update of the sports nutrition review article published as the lead paper to launch the JISSN in 2004 and presents a well-referenced overview of the current state of the science related to how to optimize training and athletic performance through nutrition. More specifically, this paper provides an overview of: 1.) The definitional category of ergogenic aids and dietary supplements; 2.) How dietary supplements are legally regulated; 3.) How to evaluate the scientific merit of nutritional supplements; 4.) General nutritional strategies to optimize performance and enhance recovery; and, 5.) An overview of our current understanding of the ergogenic value of nutrition and dietary supplementation in regards to weight gain, weight loss, and performance enhancement. Our hope is that ISSN members and individuals interested in sports nutrition find this review useful in their daily practice and consultation with their clients. PMID:20181066

  4. Energy Data Base: Serial titles with ISSN listing: Part 1, Alphabetic arrangement by title

    SciTech Connect

    Daniel, J.H.

    1986-12-01

    ''Serial Titles with ISSN Listing'' lists periodical titles which have been included in the OSTI (Office of Scientific and Technical Information) Journal Authority. The OSTI Journal Authority was established to standardize the citing of the approximately 23,000 titles contained in this authority. It is also a valuable tool for identifying journals by ISSN and CODEN, especially for journals with the same title which are published in different locations. This Part 1 is an alphabetical listing by full title of the journal publication and also includes abbreviated title, CODEN, ISSN, coverage code, and country code.

  5. Novel Target for Ameliorating Pain and Other Problems after SCI: Spontaneous Activityin Nociceptors

    DTIC Science & Technology

    2015-10-01

    the function of a sodium ion channel, Nav1.8, that is selectively expressed in primary afferent neurons (especially nociceptors) ameliorate reflex...potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat. Proc Natl Acad Sci U S A, 104:8520–8525

  6. Ready Reference. How To Obtain an ISBN; How To Obtain an ISSN; How To Obtain an SAN.

    ERIC Educational Resources Information Center

    Koltay, Emery

    2003-01-01

    These three articles describe ISBNs (International Standard Book Numbers); ISSNs (International Standard Serial Numbers); and SANs (Standard Address Numbers), for organizations served by the book industry; and explains how to apply to obtain the appropriate numbers. (LRW)

  7. Preface: SciDAC 2009

    NASA Astrophysics Data System (ADS)

    Simon, Horst

    2009-07-01

    By almost any measure, the SciDAC community has come a long way since DOE launched the SciDAC program back in 2001. At the time, we were grappling with how to efficiently run applications on terascale systems (the November 2001 TOP500 list was led by DOE's ASCI White IBM system at Lawrence Livermore achieving 7.2 teraflop/s). And the results stemming from the first round of SciDAC projects were summed up in two-page reports. The scientific results were presented at annual meetings, which were by invitation only and typically were attended by about 75 researchers. Fast forward to 2009 and we now have SciDAC Review, a quarterly magazine showcasing the scientific computing contributions of SciDAC projects and related programs, all focused on presenting a comprehensive look at Scientific Discovery through Advanced Computing. That is also the motivation behind the annual SciDAC conference that in 2009 was held from June 14-18 in San Diego. The annual conference, which can also be described as a celebration of all things SciDAC, grew out those meetings organized in the early days of the program. In 2005, the meeting was held in San Francisco and attendance was opened up to all members of the SciDAC community. The schedule was also expanded to include a keynote address, plenary speakers and other features found in a conference format. This year marks the fifth such SciDAC conference, which now comprises four days of computational science presentations, multiple poster sessions and, since last year, an evening event showcasing simulations and modeling runs resulting from SciDAC projects. The fifth annual SciDAC conference was remarkable on several levels. The primary purpose, of course, is to showcase the research accomplishments resulting from SciDAC programs in particular and computational science in general. It is these accomplishments, represented in 38 papers and 52 posters, that comprise this set of conference proceedings. These proceedings can stand alone as

  8. ISS-N1 makes the First FDA-approved Drug for Spinal Muscular Atrophy

    PubMed Central

    Ottesen, Eric W.

    2017-01-01

    Abstract Spinal muscular atrophy (SMA) is one of the leading genetic diseases of children and infants. SMA is caused by deletions or mutations of Survival Motor Neuron 1 (SMN1) gene. SMN2, a nearly identical copy of SMN1, cannot compensate for the loss of SMN1 due to predominant skipping of exon 7. While various regulatory elements that modulate SMN2 exon 7 splicing have been proposed, intronic splicing silencer N1 (ISS-N1) has emerged as the most promising target thus far for antisense oligonucleotide-mediated splicing correction in SMA. Upon procuring exclusive license from the University of Massachussets Medical School in 2010, Ionis Pharmaceuticals (formerly ISIS Pharamaceuticals) began clinical development of Spinraza™ (synonyms: Nusinersen, IONIS-SMNRX, ISIS-SMNRX), an antisense drug based on ISS-N1 target. Spinraza™ showed very promising results at all steps of the clinical development and was approved by US Food and Drug Administration (FDA) on December 23, 2016. Spinraza™ is the first FDA-approved treatment for SMA and the first antisense drug to restore expression of a fully functional protein via splicing correction. The success of Spinraza™ underscores the potential of intronic sequences as promising therapeutic targets and sets the stage for further improvement of antisense drugs based on advanced oligonucleotide chemistries and delivery protocols.

  9. Preface: SciDAC 2007

    NASA Astrophysics Data System (ADS)

    Keyes, David E.

    2007-09-01

    It takes a village to perform a petascale computation—domain scientists, applied mathematicians, computer scientists, computer system vendors, program managers, and support staff—and the village was assembled during 24-28 June 2007 in Boston's Westin Copley Place for the third annual Scientific Discovery through Advanced Computing (SciDAC) 2007 Conference. Over 300 registered participants networked around 76 posters, focused on achievements and challenges in 36 plenary talks, and brainstormed in two panels. In addition, with an eye to spreading the vision for simulation at the petascale and to growing the workforce, 115 participants—mostly doctoral students and post-docs complementary to the conferees—were gathered on 29 June 2007 in classrooms of the Massachusetts Institute of Technology for a full day of tutorials on the use of SciDAC software. Eleven SciDAC-sponsored research groups presented their software at an introductory level, in both lecture and hands-on formats that included live runs on a local BlueGene/L. Computation has always been about garnering insight into the behavior of systems too complex to explore satisfactorily by theoretical means alone. Today, however, computation is about much more: scientists and decision makers expect quantitatively reliable predictions from simulations ranging in scale from that of the Earth's climate, down to quarks, and out to colliding black holes. Predictive simulation lies at the heart of policy choices in energy and environment affecting billions of lives and expenditures of trillions of dollars. It is also at the heart of scientific debates on the nature of matter and the origin of the universe. The petascale is barely adequate for such demands and we are barely established at the levels of resolution and throughput that this new scale of computation affords. However, no scientific agenda worldwide is pushing the petascale frontier on all its fronts as vigorously as SciDAC. The breadth of this conference

  10. Preface: SciDAC 2006

    NASA Astrophysics Data System (ADS)

    Tang, William M., Dr.

    2006-01-01

    The second annual Scientific Discovery through Advanced Computing (SciDAC) Conference was held from June 25-29, 2006 at the new Hyatt Regency Hotel in Denver, Colorado. This conference showcased outstanding SciDAC-sponsored computational science results achieved during the past year across many scientific domains, with an emphasis on science at scale. Exciting computational science that has been accomplished outside of the SciDAC program both nationally and internationally was also featured to help foster communication between SciDAC computational scientists and those funded by other agencies. This was illustrated by many compelling examples of how domain scientists collaborated productively with applied mathematicians and computer scientists to effectively take advantage of terascale computers (capable of performing trillions of calculations per second) not only to accelerate progress in scientific discovery in a variety of fields but also to show great promise for being able to utilize the exciting petascale capabilities in the near future. The SciDAC program was originally conceived as an interdisciplinary computational science program based on the guiding principle that strong collaborative alliances between domain scientists, applied mathematicians, and computer scientists are vital to accelerated progress and associated discovery on the world's most challenging scientific problems. Associated verification and validation are essential in this successful program, which was funded by the US Department of Energy Office of Science (DOE OS) five years ago. As is made clear in many of the papers in these proceedings, SciDAC has fundamentally changed the way that computational science is now carried out in response to the exciting challenge of making the best use of the rapid progress in the emergence of more and more powerful computational platforms. In this regard, Dr. Raymond Orbach, Energy Undersecretary for Science at the DOE and Director of the OS has stated

  11. FAQs about Spinal Cord Injury (SCI)

    MedlinePlus

    ... spinal cord injury? Where is the nearest SCI Model System of Care? Emergency Medical Services Hospital (Acute) Care Rehabilitation More ... spinal cord injury? Where is the nearest SCI Model System of Care? Follow Us! Get Email Updates Questions & Comments Suggest ...

  12. Preface: SciDAC 2005

    NASA Astrophysics Data System (ADS)

    Mezzacappa, Anthony

    2005-01-01

    On 26-30 June 2005 at the Grand Hyatt on Union Square in San Francisco several hundred computational scientists from around the world came together for what can certainly be described as a celebration of computational science. Scientists from the SciDAC Program and scientists from other agencies and nations were joined by applied mathematicians and computer scientists to highlight the many successes in the past year where computation has led to scientific discovery in a variety of fields: lattice quantum chromodynamics, accelerator modeling, chemistry, biology, materials science, Earth and climate science, astrophysics, and combustion and fusion energy science. Also highlighted were the advances in numerical methods and computer science, and the multidisciplinary collaboration cutting across science, mathematics, and computer science that enabled these discoveries. The SciDAC Program was conceived and funded by the US Department of Energy Office of Science. It is the Office of Science's premier computational science program founded on what is arguably the perfect formula: the priority and focus is science and scientific discovery, with the understanding that the full arsenal of `enabling technologies' in applied mathematics and computer science must be brought to bear if we are to have any hope of attacking and ultimately solving today's computational Grand Challenge problems. The SciDAC Program has been in existence for four years, and many of the computational scientists funded by this program will tell you that the program has given them the hope of addressing their scientific problems in full realism for the very first time. Many of these scientists will also tell you that SciDAC has also fundamentally changed the way they do computational science. We begin this volume with one of DOE's great traditions, and core missions: energy research. As we will see, computation has been seminal to the critical advances that have been made in this arena. Of course, to

  13. Preface: SciDAC 2008

    NASA Astrophysics Data System (ADS)

    Stevens, Rick

    2008-07-01

    The fourth annual Scientific Discovery through Advanced Computing (SciDAC) Conference was held June 13-18, 2008, in Seattle, Washington. The SciDAC conference series is the premier communitywide venue for presentation of results from the DOE Office of Science's interdisciplinary computational science program. Started in 2001 and renewed in 2006, the DOE SciDAC program is the country's - and arguably the world's - most significant interdisciplinary research program supporting the development of advanced scientific computing methods and their application to fundamental and applied areas of science. SciDAC supports computational science across many disciplines, including astrophysics, biology, chemistry, fusion sciences, and nuclear physics. Moreover, the program actively encourages the creation of long-term partnerships among scientists focused on challenging problems and computer scientists and applied mathematicians developing the technology and tools needed to address those problems. The SciDAC program has played an increasingly important role in scientific research by allowing scientists to create more accurate models of complex processes, simulate problems once thought to be impossible, and analyze the growing amount of data generated by experiments. To help further the research community's ability to tap into the capabilities of current and future supercomputers, Under Secretary for Science, Raymond Orbach, launched the Innovative and Novel Computational Impact on Theory and Experiment (INCITE) program in 2003. The INCITE program was conceived specifically to seek out computationally intensive, large-scale research projects with the potential to significantly advance key areas in science and engineering. The program encourages proposals from universities, other research institutions, and industry. During the first two years of the INCITE program, 10 percent of the resources at NERSC were allocated to INCITE awardees. However, demand for supercomputing resources

  14. Complementary and alternative therapies and SCI nursing.

    PubMed

    Oliver, N R

    2001-01-01

    Increasing numbers of individuals are experimenting with different complementary and alternative techniques and practices in their quest to improve their health status or change symptom experiences. Consumer utilization patterns are described, activities to ensure the safety and efficacy of alternative practices are reviewed, and relationships to nursing interventions and nursing responsibilities are presented. The relationship between complementary/alternative therapies and spinal cord injury (SCI) nursing practice, education, and research are described, as well as strategies for integrating these therapies into SCI nursing. The potential roles for SCI nurses and benefits to individuals with SCI are unlimited.

  15. Novel Target for Ameliorating Pain and Other Problems after SCI: Spontaneous Activity in Nociceptors

    DTIC Science & Technology

    2016-06-01

    prediction that interventions that reduce the function of sodium ion channel Nav1.8 (primarily expressed in nociceptive primary afferent neurons) ameliorate...Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat. Proc Natl Acad Sci U S A, 104:8520–8525. Shields, SD, Ahn...gated sodium channel expressed by sensory neurons. Nature 379:257– 262. CrossRef Medline Akopian AN, Souslova V, England S, Okuse K, Ogata N, Ure J

  16. [SciELO: method for electronic publishing].

    PubMed

    Laerte Packer, A; Rocha Biojone, M; Antonio, I; Mayumi Takemaka, R; Pedroso García, A; Costa da Silva, A; Toshiyuki Murasaki, R; Mylek, C; Carvalho Reisl, O; Rocha F Delbucio, H C

    2001-01-01

    It describes the SciELO Methodology Scientific Electronic Library Online for electronic publishing of scientific periodicals, examining issues such as the transition from traditional printed publication to electronic publishing, the scientific communication process, the principles which founded the methodology development, its application in the building of the SciELO site, its modules and components, the tools use for its construction etc. The article also discusses the potentialities and trends for the area in Brazil and Latin America, pointing out questions and proposals which should be investigated and solved by the methodology. It concludes that the SciELO Methodology is an efficient, flexible and wide solution for the scientific electronic publishing.

  17. Astronomy Popularization via Sci-fi Movies

    NASA Astrophysics Data System (ADS)

    Li, Qingkang

    2015-08-01

    It is astronomers’ duty to let more and more young people know a bit astronomy and be interested in astronomy and appreciate the beauty and great achievements in astronomy. One of the most effective methods to popularize astronomy to young people nowadays might be via enjoying some brilliant sci-fi movies related to astronomy with some guidance from astronomers. Firstly, we will introduce the basic information of our selective course “Appreciation of Sci-fi Movies in Astronomy” for the non-major astronomy students in our University, which is surely unique in China, then we will show its effect on astronomy popularization based on several rounds of teaching.

  18. Learning by Creating and Exchanging Objects: The SCY Experience

    ERIC Educational Resources Information Center

    De Jong, Ton; Van Joolingen, Wouter R.; Giemza, Adam; Girault, Isabelle; Hoppe, Ulrich; Kindermann, Jorg; Kluge, Anders; Lazonder, Ard W.; Vold, Vibeke; Weinberger, Armin; Weinbrenner, Stefan; Wichmann, Astrid; Anjewierden, Anjo; Bodin, Marjolaine; Bollen, Lars; D'Ham, Cedric; Dolonen, Jan; Engler, Jan; Geraedts, Caspar; Grosskreutz, Henrik; Hovardas, Tasos; Julien, Rachel; Lechner, Judith; Ludvigsen, Sten; Matteman, Yuri; Meistadt, Oyvind; Naess, Bjorge; Ney, Muriel; Pedaste, Margus; Perritano, Anthony; Rinket, Marieke; Von Schlanbusch, Henrik; Sarapuu, Tago; Schulz, Florian; Sikken, Jakob; Slotta, Jim; Toussaint, Jeremy; Verkade, Alex; Wajeman, Claire; Wasson, Barbara; Zacharia, Zacharias C.; Van Der Zanden, Martine

    2010-01-01

    Science Created by You (SCY) is a project on learning in science and technology domains. SCY uses a pedagogical approach that centres around products, called "emerging learning objects" (ELOs) that are created by students. Students work individually and collaboratively in SCY-Lab (the general SCY learning environment) on "missions" that are guided…

  19. Ready Reference. Publishers' Toll-Free Telephone Numbers and Web Sites; How To Obtain an ISBN; How To Obtain an ISSN; How To Obtain an SAN.

    ERIC Educational Resources Information Center

    Koltay, Emery

    2002-01-01

    Includes four articles: one lists publishers' toll-free telephone numbers and Web sites; and the others explain how to obtain an ISBN (International Standard Book Number), an ISSN (International Standard Serial Number), and an SAN (Standard Address Number) for organizations involved in the book industry. (LRW)

  20. Opening Comments: SciDAC 2008

    NASA Astrophysics Data System (ADS)

    Strayer, Michael

    2008-07-01

    Welcome to Seattle and the 2008 SciDAC Conference. This conference, the fourth in the series, is a continuation of the PI meetings we first began under SciDAC-1. I would like to start by thanking the organizing committee, and Rick Stevens in particular, for organizing this year's meeting. This morning I would like to look briefly at SciDAC, to give you a brief history of SciDAC and also look ahead to see where we plan to go over the next few years. I think the best description of SciDAC, at least the simulation part, comes from a quote from Dr Ray Orbach, DOE's Under Secretary for Science and Director of the Office of Science. In an interview that appeared in the SciDAC Review magazine, Dr Orbach said, `SciDAC is unique in the world. There isn't any other program like it anywhere else, and it has the remarkable ability to do science by bringing together physical scientists, mathematicians, applied mathematicians, and computer scientists who recognize that computation is not something you do at the end, but rather it needs to be built into the solution of the very problem that one is addressing'. Of course, that is extended not just to physical scientists, but also to biological scientists. This is a theme of computational science, this partnership among disciplines, which goes all the way back to the early 1980s and Ken Wilson. It's a unique thread within the Department of Energy. SciDAC-1, launched around the turn of the millennium, created a new generation of scientific simulation codes. It advocated building out mathematical and computing system software in support of science and a new collaboratory software environment for data. The original concept for SciDAC-1 had topical centers for the execution of the various science codes, but several corrections and adjustments were needed. The ASCR scientific computing infrastructure was also upgraded, providing the hardware facilities for the program. The computing facility that we had at that time was the big 3

  1. Web life: Planet SciCast

    NASA Astrophysics Data System (ADS)

    2009-08-01

    So what is the site about? Planet SciCast is an online repository for short films about science - a bit like a science-specific, moderated version of YouTube. As of July 2009, the site hosts over 150 films on topics ranging from CERN's Large Hadron Collider to fun things to do with treacle. New content appears on the site every few weeks, and some films include links to information about related experiments, demos and activities. The site also runs an annual competition aimed at getting more people involved in making science films, with prizes in categories like "best original score" and "best presenter".

  2. Opening Remarks: SciDAC 2007

    NASA Astrophysics Data System (ADS)

    Strayer, Michael

    2007-09-01

    Good morning. Welcome to Boston, the home of the Red Sox, Celtics and Bruins, baked beans, tea parties, Robert Parker, and SciDAC 2007. A year ago I stood before you to share the legacy of the first SciDAC program and identify the challenges that we must address on the road to petascale computing—a road E E Cummins described as `. . . never traveled, gladly beyond any experience.' Today, I want to explore the preparations for the rapidly approaching extreme scale (X-scale) generation. These preparations are the first step propelling us along the road of burgeoning scientific discovery enabled by the application of X- scale computing. We look to petascale computing and beyond to open up a world of discovery that cuts across scientific fields and leads us to a greater understanding of not only our world, but our universe. As part of the President's America Competitiveness Initiative, the ASCR Office has been preparing a ten year vision for computing. As part of this planning the LBNL together with ORNL and ANL hosted three town hall meetings on Simulation and Modeling at the Exascale for Energy, Ecological Sustainability and Global Security (E3). The proposed E3 initiative is organized around four programmatic themes: Engaging our top scientists, engineers, computer scientists and applied mathematicians; investing in pioneering large-scale science; developing scalable analysis algorithms, and storage architectures to accelerate discovery; and accelerating the build-out and future development of the DOE open computing facilities. It is clear that we have only just started down the path to extreme scale computing. Plan to attend Thursday's session on the out-briefing and discussion of these meetings. The road to the petascale has been at best rocky. In FY07, the continuing resolution provided 12% less money for Advanced Scientific Computing than either the President, the Senate, or the House. As a consequence, many of you had to absorb a no cost extension for your

  3. Using SciDB to Support Photon Science Data Analysis

    SciTech Connect

    Becla, Jack; Wang, Daniel; lim, Kian-Tat; /SLAC

    2012-02-15

    Array data analytic systems like SciDB hold great potential to accelerate processing data from SLAC's Linac Coherent Light Source and other experiments. SciDB is unique in its ability to integrate storage and processing of array data efficiently, providing both space-efficient storage and out-of-memory efficient parallel array processing. We describe a recent effort to leverage SciDB to store and process LCLS data. The work includes development of software to import data into SciDB, subsequent benchmarks, and interactive manipulation of data in SciDB.

  4. SciDAC Institute for Ultrascale Visualization

    SciTech Connect

    Humphreys, Grigori R.

    2008-09-30

    The Institute for Ultrascale Visualization aims to address visualization needs of SciDAC science domains, including research topics in advanced scientific visualization architectures, algorithms, and interfaces for understanding large, complex datasets. During the current project period, the focus of the team at the University of Virginia has been interactive remote rendering for scientific visualization. With high-performance computing resources enabling increasingly complex simulations, scientists may desire to interactively visualize huge 3D datasets. Traditional large-scale 3D visualization systems are often located very close to the processing clusters, and are linked to them with specialized connections for high-speed rendering. However, this tight coupling of processing and display limits possibilities for remote collaboration, and prohibits scientists from using their desktop workstations for data exploration. In this project, we are developing a client/server system for interactive remote 3D visualization on desktop computers.

  5. Opening Comments: SciDAC 2009

    NASA Astrophysics Data System (ADS)

    Strayer, Michael

    2009-07-01

    Welcome to San Diego and the 2009 SciDAC conference. Over the next four days, I would like to present an assessment of the SciDAC program. We will look at where we've been, how we got to where we are and where we are going in the future. Our vision is to be first in computational science, to be best in class in modeling and simulation. When Ray Orbach asked me what I would do, in my job interview for the SciDAC Director position, I said we would achieve that vision. And with our collective dedicated efforts, we have managed to achieve this vision. In the last year, we have now the most powerful supercomputer for open science, Jaguar, the Cray XT system at the Oak Ridge Leadership Computing Facility (OLCF). We also have NERSC, probably the best-in-the-world program for productivity in science that the Office of Science so depends on. And the Argonne Leadership Computing Facility offers architectural diversity with its IBM Blue Gene/P system as a counterbalance to Oak Ridge. There is also ESnet, which is often understated—the 40 gigabit per second dual backbone ring that connects all the labs and many DOE sites. In the President's Recovery Act funding, there is exciting news that ESnet is going to build out to a 100 gigabit per second network using new optical technologies. This is very exciting news for simulations and large-scale scientific facilities. But as one noted SciDAC luminary said, it's not all about the computers—it's also about the science—and we are also achieving our vision in this area. Together with having the fastest supercomputer for science, at the SC08 conference, SciDAC researchers won two ACM Gordon Bell Prizes for the outstanding performance of their applications. The DCA++ code, which solves some very interesting problems in materials, achieved a sustained performance of 1.3 petaflops, an astounding result and a mark I suspect will last for some time. The LS3DF application for studying nanomaterials also required the development of a

  6. A millenium approach to Data Acquisition: SCI and PCI

    NASA Astrophysics Data System (ADS)

    Müller, Hans; Bogaerts, A.; Lindenstruth, V.

    The international SCI standard IEEE/ANSI 1596a [Ref. 1.] is on its way to become the computer interconnect of the year 2000 since for a first time, low latency desktop multiprocessing and cluster computing can be implemented at low cost. The PCI bus is todays's dominating local bus extension for all major computer platforms as well as for buses like VMEbus. PCI is a self configuring memory and I/O system for peripheral components with a hierarchical architecture. SCI is a scalable, bus-like interconnect for distributed processors and memories. It allows for optionally coherent data caching and assures errorfree data delivery. First measurement with commercial SCI products (SBUS-SCI) confirm simulations that SCI can handle even the highest data rates of LHC experiments. The eventbuilder layer for a millenium very high rate DAQ system can therefore be viewed as a SCI network ( bridges, cables & switches) interfaced between PCI buses on the frontend (VMEb ) side and on the processor farm ( Multi-CPU) side. Such a combination of SCI and PCI enables PCI-PCI memory access, transparently across SCI. It also allows for a novel, low level trigger technique: the trigger algorithm can access VME data buffers with bus-like latencies like local memory, i.e. full data transfers become redundent. The first prototype of a PCI-SCI bridge for DAQ is presented as starting point for a test system with built-in scalability.

  7. Complex I assembly function and fatty acid oxidation enzyme activity of ACAD9 both contribute to disease severity in ACAD9 deficiency

    PubMed Central

    Schiff, Manuel; Haberberger, Birgit; Xia, Chuanwu; Mohsen, Al-Walid; Goetzman, Eric S.; Wang, Yudong; Uppala, Radha; Zhang, Yuxun; Karunanidhi, Anuradha; Prabhu, Dolly; Alharbi, Hana; Prochownik, Edward V.; Haack, Tobias; Häberle, Johannes; Munnich, Arnold; Rötig, Agnes; Taylor, Robert W.; Nicholls, Robert D.; Kim, Jung-Ja; Prokisch, Holger; Vockley, Jerry

    2015-01-01

    Acyl-CoA dehydrogenase 9 (ACAD9) is an assembly factor for mitochondrial respiratory chain Complex I (CI), and ACAD9 mutations are recognized as a frequent cause of CI deficiency. ACAD9 also retains enzyme ACAD activity for long-chain fatty acids in vitro, but the biological relevance of this function remains controversial partly because of the tissue specificity of ACAD9 expression: high in liver and neurons and minimal in skin fibroblasts. In this study, we hypothesized that this enzymatic ACAD activity is required for full fatty acid oxidation capacity in cells expressing high levels of ACAD9 and that loss of this function is important in determining phenotype in ACAD9-deficient patients. First, we confirmed that HEK293 cells express ACAD9 abundantly. Then, we showed that ACAD9 knockout in HEK293 cells affected long-chain fatty acid oxidation along with Cl, both of which were rescued by wild type ACAD9. Further, we evaluated whether the loss of ACAD9 enzymatic fatty acid oxidation affects clinical severity in patients with ACAD9 mutations. The effects on ACAD activity of 16 ACAD9 mutations identified in 24 patients were evaluated using a prokaryotic expression system. We showed that there was a significant inverse correlation between residual enzyme ACAD activity and phenotypic severity of ACAD9-deficient patients. These results provide evidence that in cells where it is strongly expressed, ACAD9 plays a physiological role in fatty acid oxidation, which contributes to the severity of the phenotype in ACAD9-deficient patients. Accordingly, treatment of ACAD9 patients should aim at counteracting both CI and fatty acid oxidation dysfunctions. PMID:25721401

  8. Complex I assembly function and fatty acid oxidation enzyme activity of ACAD9 both contribute to disease severity in ACAD9 deficiency.

    PubMed

    Schiff, Manuel; Haberberger, Birgit; Xia, Chuanwu; Mohsen, Al-Walid; Goetzman, Eric S; Wang, Yudong; Uppala, Radha; Zhang, Yuxun; Karunanidhi, Anuradha; Prabhu, Dolly; Alharbi, Hana; Prochownik, Edward V; Haack, Tobias; Häberle, Johannes; Munnich, Arnold; Rötig, Agnes; Taylor, Robert W; Nicholls, Robert D; Kim, Jung-Ja; Prokisch, Holger; Vockley, Jerry

    2015-06-01

    Acyl-CoA dehydrogenase 9 (ACAD9) is an assembly factor for mitochondrial respiratory chain Complex I (CI), and ACAD9 mutations are recognized as a frequent cause of CI deficiency. ACAD9 also retains enzyme ACAD activity for long-chain fatty acids in vitro, but the biological relevance of this function remains controversial partly because of the tissue specificity of ACAD9 expression: high in liver and neurons and minimal in skin fibroblasts. In this study, we hypothesized that this enzymatic ACAD activity is required for full fatty acid oxidation capacity in cells expressing high levels of ACAD9 and that loss of this function is important in determining phenotype in ACAD9-deficient patients. First, we confirmed that HEK293 cells express ACAD9 abundantly. Then, we showed that ACAD9 knockout in HEK293 cells affected long-chain fatty acid oxidation along with Cl, both of which were rescued by wild type ACAD9. Further, we evaluated whether the loss of ACAD9 enzymatic fatty acid oxidation affects clinical severity in patients with ACAD9 mutations. The effects on ACAD activity of 16 ACAD9 mutations identified in 24 patients were evaluated using a prokaryotic expression system. We showed that there was a significant inverse correlation between residual enzyme ACAD activity and phenotypic severity of ACAD9-deficient patients. These results provide evidence that in cells where it is strongly expressed, ACAD9 plays a physiological role in fatty acid oxidation, which contributes to the severity of the phenotype in ACAD9-deficient patients. Accordingly, treatment of ACAD9 patients should aim at counteracting both CI and fatty acid oxidation dysfunctions.

  9. SciDB and Geoinformatics Analysis

    NASA Astrophysics Data System (ADS)

    Brown, Paul

    2015-04-01

    The SciDB project took as its design goals a list of features identified as being critical to scientific data management in a survey of working scientists (Stonebraker et al 2009). Earth scientists working with remote sensing data were well represented among those polled so it should come as no surprise that the platform has been embraced by that community. In this talk we focus on work done by researchers at NASA and INPE, and on applications created by commercial data providers in Korea and the United States. For each use-case, we will review the project team's objectives, the nature and quantity of the data involved, the their workload queries. As we discuss each use-case we will describe what is emerging as "best practice" for data management and analysis in this space. M. Stonebraker, J. Becla, D. J. DeWitt, K. T. Lim, D. Maier, O. Ratzesberger, and S. B. Zdonik. Requirements for science data bases and scidb. In CIDR 2009, Fourth Biennial Conference on Innovative Data Systems Research, Asilomar, CA, USA, January 4-7, 2009, Online Proceedings, 2009.

  10. Experiences using SciPy for computer vision research

    SciTech Connect

    Eads, Damian R; Rosten, Edward J

    2008-01-01

    SciPy is an effective tool suite for prototyping new algorithms. We share some of our experiences using it for the first time to support our research in object detection. SciPy makes it easy to integrate C code, which is essential when algorithms operating on large data sets cannot be vectorized. The universality of Python, the language in which SciPy was written, gives the researcher access to a broader set of non-numerical libraries to support GUI development, interface with databases, manipulate graph structures. render 3D graphics, unpack binary files, etc. Python's extensive support for operator overloading makes SciPy's syntax as succinct as its competitors, MATLAB, Octave, and R. More profoundly, we found it easy to rework research code written with SciPy into a production application, deployable on numerous platforms.

  11. 75 FR 24747 - SCI, LLC/Zener-Rectifier Operations Division A Wholly Owned Subsidiary of SCI, LLC/ON...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-05

    ... Phoenix, AZ; Amended Certification Regarding Eligibility To Apply for Worker Adjustment Assistance In... of SCI, LLC/ON Semiconductor, Phoenix, Arizona. The notice was published in the Federal Register on... at the Phoenix Arizona location of SCI LLC/Zener-Rectifier, Operations Division, a wholly...

  12. Reliability and validity of the Automatic Cognitive Assessment Delivery (ACAD).

    PubMed

    Di Rosa, Elisa; Hannigan, Caoimhe; Brennan, Sabina; Reilly, Richard; Rapčan, Viliam; Robertson, Ian H

    2014-01-01

    IN THIS STUDY WE EVALUATED RELIABILITY AND VALIDITY OF THE AUTOMATIC COGNITIVE ASSESSMENT DELIVERY (ACAD): a short computerized battery composed by memory and attention tests, delivered online, and designed primarily for the elderly. Reliability was examined with a test-retest design and validity was assessed by means of comparison with standard neuropsychological tests. Older (N = 32) and young adult participants (N = 21) were involved. We found that the ACAD is free from any practice effect. Test-retest reliability was confirmed via significant correlations and high percentage agreements between the scores of three repeated assessments. ACAD scores were lower for older than for young adult participants and correlated significantly with the standardized measures of memory and attention. Results demonstrate that the ACAD battery provides a reliable and valid measure of both immediate and delayed recognition memory and sustained attention, and may be useful for convenient and efficient cognitive assessment and monitoring in older adults.

  13. Status of FNAL SciBooNE experiment

    SciTech Connect

    Nakajima, Yasuhiro; /Kyoto U.

    2007-12-01

    SciBooNE is a new experiment at FNAL which will make precision neutrino-nucleus cross section measurements in the one GeV region. These measurements are essential for the future neutrino oscillation experiments. We started data taking in the antineutrino mode on June 8, 2007, and collected 5.19 x 10{sup 19} protons on target (POT) before the accelerator shutdown in August. The first data from SciBooNE are reported in this article.

  14. Introduction to Searching with SciFinder Scholar

    NASA Astrophysics Data System (ADS)

    Ridley, Damon D.

    2001-04-01

    With SciFinder Scholar now one of the preferred access routes to information in the sciences, many college information retrieval courses that dealt with online networks need to be redesigned. Although one of the basic assumptions within the design of SciFinder Scholar is that staff and students may retrieve valuable answers with little training, nevertheless, with a little instruction improved search results may be obtained. We present here our basic teaching program for senior undergraduate and postgraduate classes.

  15. Solving Large-scale Eigenvalue Problems in SciDACApplications

    SciTech Connect

    Yang, Chao

    2005-06-29

    Large-scale eigenvalue problems arise in a number of DOE applications. This paper provides an overview of the recent development of eigenvalue computation in the context of two SciDAC applications. We emphasize the importance of Krylov subspace methods, and point out its limitations. We discuss the value of alternative approaches that are more amenable to the use of preconditioners, and report the progression using the multi-level algebraic sub-structuring techniques to speed up eigenvalue calculation. In addition to methods for linear eigenvalue problems, we also examine new approaches to solving two types of non-linear eigenvalue problems arising from SciDAC applications.

  16. SciTech Clubs for Girls. [Annual] technical report

    SciTech Connect

    Nogal, A.M.

    1993-02-01

    Since January 1992, 9 exhibits have been constructed by the SciTech Clubs for Girls, which involved 63 girls, ages 10 to 14. These exhibits are: Bubble Shapes by the St. Charles Cadette Girl Scout Troop No. 109. Density Games by the South Elgin Cadette Girl Scout Troop No. 132. Electric Fleas by the Warrenville Junior Girl Scout Troop No. 305. Energy vs. Power by the Aurora Junior Girl Scout Troop No. 242. The Organ Pipe by the Bartlett Junior Girl Scout Troop No. 107. Ohm`s Law by the Geneva Junior Girl Scout Troop No. 401. What is Gravity by the Pilsen YMCA girls. Insulation at Work by the Algonquin Junior Girl Scout Troop No. 303. Series vs. Parallel by the Leland Junior Girl Scout Troop No. 50. The report is a description of each exhibit and the group that built the exhibit. Each group had a minimum of 10 hours of contact time at SciTech with the SciTech Clubs for Girls Program Coordinator. All mentors are female. Each exhibit building experience includes a trip to the hardware store to purchase supplies. After the exhibit is complete, the girls receive certificates of achievement and a SciTech Club Patch.

  17. Combined SCI and TBI: recovery of forelimb function after unilateral cervical spinal cord injury (SCI) is retarded by contralateral traumatic brain injury (TBI), and ipsilateral TBI balances the effects of SCI on paw placement.

    PubMed

    Inoue, Tomoo; Lin, Amity; Ma, Xiaokui; McKenna, Stephen L; Creasey, Graham H; Manley, Geoffrey T; Ferguson, Adam R; Bresnahan, Jacqueline C; Beattie, Michael S

    2013-10-01

    A significant proportion (estimates range from 16 to 74%) of patients with spinal cord injury (SCI) have concomitant traumatic brain injury (TBI), and the combination often produces difficulties in planning and implementing rehabilitation strategies and drug therapies. For example, many of the drugs used to treat SCI may interfere with cognitive rehabilitation, and conversely drugs that are used to control seizures in TBI patients may undermine locomotor recovery after SCI. The current paper presents an experimental animal model for combined SCI and TBI to help drive mechanistic studies of dual diagnosis. Rats received a unilateral SCI (75 kdyn) at C5 vertebral level, a unilateral TBI (2.0 mm depth, 4.0 m/s velocity impact on the forelimb sensori-motor cortex), or both SCI+TBI. TBI was placed either contralateral or ipsilateral to the SCI. Behavioral recovery was examined using paw placement in a cylinder, grooming, open field locomotion, and the IBB cereal eating test. Over 6weeks, in the paw placement test, SCI+contralateral TBI produced a profound deficit that failed to recover, but SCI+ipsilateral TBI increased the relative use of the paw on the SCI side. In the grooming test, SCI+contralateral TBI produced worse recovery than either lesion alone even though contralateral TBI alone produced no observable deficit. In the IBB forelimb test, SCI+contralateral TBI revealed a severe deficit that recovered in 3 weeks. For open field locomotion, SCI alone or in combination with TBI resulted in an initial deficit that recovered in 2 weeks. Thus, TBI and SCI affected forelimb function differently depending upon the test, reflecting different neural substrates underlying, for example, exploratory paw placement and stereotyped grooming. Concurrent SCI and TBI had significantly different effects on outcomes and recovery, depending upon laterality of the two lesions. Recovery of function after cervical SCI was retarded by the addition of a moderate TBI in the contralateral

  18. Combined SCI and TBI: Recovery of forelimb function after unilateral cervical spinal cord injury (SCI) is retarded by contralateral traumatic brain injury (TBI), and ipsilateral TBI balances the effects of SCI on paw placement

    PubMed Central

    Inoue, Tomoo; Lin, Amity; Ma, Xiaokui; McKenna, Stephen L.; Creasey, Graham H.; Manley, Geoffrey T.; Ferguson, Adam R.; Bresnahan, Jacqueline C.; Beattie, Michael S.

    2015-01-01

    A significant proportion (estimates range from 16–74%) of patients with spinal cord injury (SCI) have concomitant traumatic brain injury (TBI), and the combination often produces difficulties in planning and implementing rehabilitation strategies and drug therapies. For example, many of the drugs used to treat SCI may interfere with cognitive rehabilitation, and conversely drugs that are used to control seizures in TBI patients may undermine locomotor recovery after SCI. The current paper presents an experimental animal model for combined SCI and TBI to help drive mechanistic studies of dual diagnosis. Rats received a unilateral SCI (75 kdyn) at C5 vertebral level, a unilateral TBI (2.0 mm depth, 4.0 m/s velocity impact on the forelimb sensori-motor cortex), or both SCI + TBI. TBI was placed either contralateral or ipsilateral to the SCI. Behavioral recovery was examined using paw placement in a cylinder, grooming, open field locomotion, and the IBB cereal eating test. Over 6 weeks, in the paw placement test, SCI + contralateral TBI produced a profound deficit that failed to recover, but SCI + ipsilateral TBI increased the relative use of the paw on the SCI side. In the grooming test, SCI + contralateral TBI produced worse recovery than either lesion alone even though contralateral TBI alone produced no observable deficit. In the IBB forelimb test, SCI + contralateral TBI revealed a severe deficit that recovered in 3 weeks. For open field locomotion, SCI alone or in combination with TBI resulted in an initial deficit that recovered in 2 weeks. Thus, TBI and SCI affected forelimb function differently depending upon the test, reflecting different neural substrates underlying, for example, exploratory paw placement and stereotyped grooming. Concurrent SCI and TBI had significantly different effects on outcomes and recovery, depending upon laterality of the two lesions. Recovery of function after cervical SCI was retarded by the addition of a moderate TBI in the

  19. Overview of the Scalable Coherent Interface, IEEE STD 1596 (SCI)

    SciTech Connect

    Gustavson, D.B.; James, D.V.; Wiggers, H.A.

    1992-10-01

    The Scalable Coherent Interface standard defines a new generation of interconnection that spans the full range from supercomputer memory `bus` to campus-wide network. SCI provides bus-like services and a shared-memory software model while using an underlying, packet protocol on many independent communication links. Initially these links are 1 GByte/s (wires) and 1 GBit/s (fiber), but the protocol scales well to future faster or lower-cost technologies. The interconnect may use switches, meshes, and rings. The SCI distributed-shared-memory model is simple and versatile, enabling for the first time a smooth integration of highly parallel multiprocessors, workstations, personal computers, I/O, networking and data acquisition.

  20. Distributed job scheduling in SCI Local Area MultiProcessors

    SciTech Connect

    Agasaveeran, S.; Li, Qiang

    1996-12-31

    Local Area MultiProcessors (LAMP) is a network of personal workstations with distributed shared physical memory provided by high performance technologies such as SCI. LAMP is more tightly coupled than the traditional local area networks (LAN) but is more loosely coupled than the bus based multiprocessors. This paper presents a distributed scheduling algorithm which exploits the distributed shared memory in SCI-LAMP to schedule the idle remote processors among the requesting workstations. It considers fairness by allocating remote processing capacity to the requesting workstations based on their priorities according to the decay-usage scheduling approach. The performance of the algorithm in scheduling both sequential and parallel jobs is evaluated by simulation. It is found that the higher priority nodes achieve faster job response times and higher speedups than that of the lower priority nodes. Lower scheduling overhead allows finer granularity of remote processors sharing than in LAN.

  1. Molecular Determinants Fundamental to Axon Regeneration after SCI

    DTIC Science & Technology

    2013-10-01

    adult zebrafish (Specific Aim 1). We also will examine in vivo the role of PTP σ in inhibition of axon regeneration (Specific Aim 2). In addition, we...AWARD NUMBER: W81XWH-11-1-0645 TITLE: Molecular Determinants Fundamental to Axon Regeneration ... Regeneration after SCI 5b. GRANT NUMBER W81XWH-11-1-0645 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER Jeffrey Alan Plunkett, Ph.D

  2. Utilization of SciFinder Scholar at an Undergraduate Institution

    NASA Astrophysics Data System (ADS)

    O'Reilly, Stacy A.; Wilson, Anne M.; Howes, Barbara

    2002-04-01

    The use of tools to search chemical information databases continues to be important to science educators. The ability to perform online searches of Chemical Abstracts Service can have a significant impact on teaching and research. The implementation of SciFinder Scholar at Butler University has resulted in significant changes in teaching, student-based research, and faculty development in the Chemistry Department. Details of these changes in courses, student research projects and proposals, and the professional growth of the faculty are discussed.

  3. Online Registries for Researchers: Using ORCID and SciENcv.

    PubMed

    Vrabel, Mark

    2016-12-01

    The Open Researcher and Contributor ID (ORCID) registry helps resolve name ambiguity by assigning persistent unique identifiers that automatically link to a researcher's publications, grants, and other activities. This article provides an overview of ORCID and its benefits, citing several examples of its use in cancer and nursing journals. The article also briefly describes My NCBI and the Science Experts Network Curriculum Vitae (SciENcv) and its connection to ORCID.

  4. An Implantable Neuroprosthetic Device to Normalize Bladder Function after SCI

    DTIC Science & Technology

    2014-12-01

    experiments using cats . These results have laid the foundation for us to further design and develop an implantable stimulator for human application in...experiments using cats . These results have laid the foundation for us to further design and develop this implantable stimulator into human application in...stimulator system Our previous studies [1-4] in anesthetized chronic SCI cats showed that blocking pudendal nerves using high-frequency (6-10 kHz

  5. 75 FR 19626 - Notice of Intent To Grant Exclusive Patent License: SciTech Medical Inc.

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-15

    ... Exclusive Patent License: SciTech Medical Inc. AGENCY: Department of the Navy, DoD. ACTION: Notice. SUMMARY... SciTech Medical Inc. The proposed license is a revocable, nonassignable, partially exclusive...

  6. OPENING REMARKS: SciDAC: Scientific Discovery through Advanced Computing

    NASA Astrophysics Data System (ADS)

    Strayer, Michael

    2005-01-01

    Good morning. Welcome to SciDAC 2005 and San Francisco. SciDAC is all about computational science and scientific discovery. In a large sense, computational science characterizes SciDAC and its intent is change. It transforms both our approach and our understanding of science. It opens new doors and crosses traditional boundaries while seeking discovery. In terms of twentieth century methodologies, computational science may be said to be transformational. There are a number of examples to this point. First are the sciences that encompass climate modeling. The application of computational science has in essence created the field of climate modeling. This community is now international in scope and has provided precision results that are challenging our understanding of our environment. A second example is that of lattice quantum chromodynamics. Lattice QCD, while adding precision and insight to our fundamental understanding of strong interaction dynamics, has transformed our approach to particle and nuclear science. The individual investigator approach has evolved to teams of scientists from different disciplines working side-by-side towards a common goal. SciDAC is also undergoing a transformation. This meeting is a prime example. Last year it was a small programmatic meeting tracking progress in SciDAC. This year, we have a major computational science meeting with a variety of disciplines and enabling technologies represented. SciDAC 2005 should position itself as a new corner stone for Computational Science and its impact on science. As we look to the immediate future, FY2006 will bring a new cycle to SciDAC. Most of the program elements of SciDAC will be re-competed in FY2006. The re-competition will involve new instruments for computational science, new approaches for collaboration, as well as new disciplines. There will be new opportunities for virtual experiments in carbon sequestration, fusion, and nuclear power and nuclear waste, as well as collaborations

  7. Orthostatic Responses to Anticholinesterase Inhibition in Persons with SCI

    PubMed Central

    Wecht, Jill M.; Cirnigliaro, Christopher M.; Azarelo, Frank; Bauman, William A.; Kirshblum, Steven C.

    2015-01-01

    Acetylcholine (Ach) is the pre-synaptic neurotransmitter of the sympathetic nervous system. Increased pre-synaptic Ach may augment post-synaptic release of norepinephrine thereby increasing systemic blood pressure (BP). The primary objective of this investigation was to determine the hemodynamic effect of pyridostigmine bromide (PYRIDO: 60 mg), an Ach inhibitor (AchI), compared to no-drug (NO-D) during head-up tilt (HUT) in individuals with spinal cord injury (SCI). Secondarily we aimed to determine the effects of PYRIDO compared to NO-D on symptoms of orthostatic intolerance (OI) and adverse event reporting (AE). Ten individuals with SCI (C4–C7) were studied on 2 occasions: visit 1) NO-D and visit 2) PYRIDO. On each visit subjects underwent a progressive HUT maneuver to 15°, 25°, 35° for 5 minutes at each angle and 45 minutes at 45°. Supine and orthostatic heart rate (HR), systolic and diastolic BP (SBP & DBP) were monitored and symptoms of OI and AE recorded. Supine hemodynamics did not differ between the trials. The significant fall in SBP during the NO-D trial was diminished with PYRIDO and five subjects had an increased DBP during HUT with PYRIDO compared to the NO-D trial. Individuals that responded to PYRIDO with an increase in orthostatic BP had significantly lower resting HR than non-responders (p<0.01), which suggests increased levels of pre-synaptic Ach. Subjective symptoms of OI and AE reporting did not differ between the two trials. These preliminary data suggest that PYRIDO is safe and may be effective at ameliorating the orthostatic fall in BP in select individuals with SCI. PMID:25916633

  8. Nuclear Physics in the SciDAC Era

    SciTech Connect

    Robert Edwards

    2009-08-01

    Lattice QCD currently provides our only means of solving QCD (Quantum Chromo Dynamics) -- the theory of the strong nuclear force -- in the low-energy regime, and thus of crucial importance for theoretical and experimental research programs in High Energy and Nuclear Physics. Under the SciDAC program, a software infrastructure has been developed for lattice QCD that effectively utilize the capabilities of the INCITE facilities. These developments have enabled a new generation of Nuclear Physics calculations investigating the spectrum and structure of matter, such as the origin of mass and spin. This software infrastructure is described and recent results are reviewed.

  9. Strategies for chemical reaction searching in SciFinder

    PubMed

    Ridley

    2000-09-01

    The bibliographic, chemical structure, and chemical reaction databases produced by Chemical Abstracts Service allow a number of possibilities for chemical reaction searching. While these same databases may be searched through the STN network, many end-users find the intuitive software interface SciFinder simpler, but there still are issues to address. Searching may be performed through keywords, chemical structures, or chemical reactions, and the answers may vary with respect to precision and comprehension. Often combinations of search options may be needed to best solve the problem. Retrosynthetic analyses are easily performed in the chemical reaction database and can give unique insights into synthetic alternatives.

  10. Introduction to Structure Searching with SciFinder Scholar

    NASA Astrophysics Data System (ADS)

    Ridley, Damon D.

    2001-04-01

    CAS Registry Numbers provide a key to searching for chemical substances in CAS databases, and the challenge is to obtain the Registry Numbers for all the substances required. When the substances can be represented by structures, then one option is to find the Registry Numbers through structure searches. With SciFinder Scholar, the process of drawing and searching structures is intuitive; however, there are underlying issues and opportunities that need some explanation in courses on chemical information retrieval.We describe here our introductory course, which addresses the major ones.

  11. Psychometric evaluation of the Spanish version of the MPI-SCI

    PubMed Central

    Soler, MD; Cruz-Almeida, Y; Saurí, J; Widerström-Noga, EG

    2013-01-01

    Study design Postal surveys. Objectives To confirm the factor structure of the Spanish version of the MPI-SCI (MPI-SCI-S, Multidimensional Pain Inventory in the SCI population) and to test its internal consistency and construct validity in a Spanish population. Setting Guttmann Institute, Barcelona, Spain. Methods The MPI-SCI-S along with Spanish measures of pain intensity (Numerical Rating Scale), pain interference (Brief Pain Inventory), functional independence (Functional Independence Measure), depression (Beck Depression Inventory), locus of control (Multidimensional health Locus of Control), support (Functional Social Support Questionnaire (Duke-UNC)), psychological well-being (Psychological Global Well-Being Index) and demographic/injury characteristics were assessed in persons with spinal cord injury (SCI) and chronic pain (n = 126). Results Confirmatory factor analysis suggested an adequate factor structure for the MPI-SCI-S. The internal consistency of the MPI-SCI-S subscales ranged from acceptable (r = 0.66, Life Control) to excellent (r = 0.94, Life Interference). All MPI-SCI-S subscales showed adequate construct validity, with the exception of the Negative and Solicitous Responses subscales. Conclusions The Spanish version of the MPI-SCI is adequate for evaluating chronic pain impact following SCI in a Spanish-speaking population. Future studies should include additional measures of pain-related support in the Spanish-speaking SCI population. PMID:23608807

  12. SciFi - A large scintillating fibre tracker for LHCb

    NASA Astrophysics Data System (ADS)

    Kirn, Thomas

    2017-02-01

    The LHCb detector will be upgraded during the Long Shutdown 2 (LS2) of the LHC in order to cope with higher instantaneous luminosities and to read out the data at 40 MHz using a trigger-less read-out system. All front-end electronics will be replaced and several sub-detectors must be redesigned to cope with higher occupancy. The current tracking detectors downstream of the LHCb dipole magnet will be replaced by the Scintillating Fibre (SciFi) Tracker. Concept, design and operational parameters are driven by the challenging LHC environment including significant ionising and neutron radiation levels. Over a total active surface of 360 m2 the SciFi Tracker will use scintillating fibres (∅ = 0.25 mm) read out by state-of-the-art multi-channel Silicon Photomultipliers (SiPMs) arrays. A custom ASIC will be used to digitise the signals from the SiPMs. The project is now at the transition from R&D to series production. We will present the evolution of the design and the latest lab and test beam results.

  13. A Design Method for FES Bone Health Therapy in SCI

    PubMed Central

    Andrews, Brian; Shippen, James; Armengol, Monica; Gibbons, Robin; Holderbaum, William; Harwin, William

    2016-01-01

    FES assisted activities such as standing, walking, cycling and rowing induce forces within the leg bones and have been proposed to reduce osteoporosis in spinal cord injury (SCI). However, details of the applied mechanical stimulus for osteogenesis is often not reported. Typically, comparisons of bone density results are made after costly and time consuming clinical trials. These studies have produced inconsistent results and are subject to sample size variations. Here we propose a design process that may be used to predict the clinical outcome based on biomechanical simulation and mechano-biology. This method may allow candidate therapies to be optimized and quantitatively compared. To illustrate the approach we have used data obtained from a rower with complete paraplegia using the RowStim (III) system. PMID:28078075

  14. eSciMart: Web Platform for Scientific Software Marketplace

    NASA Astrophysics Data System (ADS)

    Kryukov, A. P.; Demichev, A. P.

    2016-10-01

    In this paper we suggest a design of a web marketplace where users of scientific application software and databases, presented in the form of web services, as well as their providers will have presence simultaneously. The model, which will be the basis for the web marketplace is close to the customer-to-customer (C2C) model, which has been successfully used, for example, on the auction sites such as eBay (ebay.com). Unlike the classical model of C2C the suggested marketplace focuses on application software in the form of web services, and standardization of API through which application software will be integrated into the web marketplace. A prototype of such a platform, entitled eSciMart, is currently being developed at SINP MSU.

  15. ScienceDirect through SciVerse: a new way to approach Elsevier.

    PubMed

    Bengtson, Jason

    2011-01-01

    SciVerse is the new combined portal from Elsevier that services their ScienceDirect collection, SciTopics, and their Scopus database. Using SciVerse to access ScienceDirect is the specific focus of this review. Along with advanced keyword searching and citation searching options, SciVerse also incorporates a very useful image search feature. The aim seems to be not only to create an interface that provides broad functionality on par with other database search tools that many searchers use regularly but also to create an open platform that could be changed to respond effectively to the needs of customers.

  16. Methodology for the development and calibration of the SCI-QOL item banks

    PubMed Central

    Tulsky, David S.; Kisala, Pamela A.; Victorson, David; Choi, Seung W.; Gershon, Richard; Heinemann, Allen W.; Cella, David

    2015-01-01

    Objective To develop a comprehensive, psychometrically sound, and conceptually grounded patient reported outcomes (PRO) measurement system for individuals with spinal cord injury (SCI). Methods Individual interviews (n = 44) and focus groups (n = 65 individuals with SCI and n = 42 SCI clinicians) were used to select key domains for inclusion and to develop PRO items. Verbatim items from other cutting-edge measurement systems (i.e. PROMIS, Neuro-QOL) were included to facilitate linkage and cross-population comparison. Items were field tested in a large sample of individuals with traumatic SCI (n = 877). Dimensionality was assessed with confirmatory factor analysis. Local item dependence and differential item functioning were assessed, and items were calibrated using the item response theory (IRT) graded response model. Finally, computer adaptive tests (CATs) and short forms were administered in a new sample (n = 245) to assess test-retest reliability and stability. Participants and Procedures A calibration sample of 877 individuals with traumatic SCI across five SCI Model Systems sites and one Department of Veterans Affairs medical center completed SCI-QOL items in interview format. Results We developed 14 unidimensional calibrated item banks and 3 calibrated scales across physical, emotional, and social health domains. When combined with the five Spinal Cord Injury – Functional Index physical function banks, the final SCI-QOL system consists of 22 IRT-calibrated item banks/scales. Item banks may be administered as CATs or short forms. Scales may be administered in a fixed-length format only. Conclusions The SCI-QOL measurement system provides SCI researchers and clinicians with a comprehensive, relevant and psychometrically robust system for measurement of physical-medical, physical-functional, emotional, and social outcomes. All SCI-QOL instruments are freely available on Assessment CenterSM. PMID:26010963

  17. "Sci-Tech - Couldn't be without it !"

    NASA Astrophysics Data System (ADS)

    2002-03-01

    Launch of a Major European Outreach Programme Seven of Europe's leading Research Organizations [1] launch joint outreach programme for the European Science and Technology Week at the Technopolis Museum in Brussels on 22 March. Their aim is to show Europeans how today's society couldn't be without fundamental research . Could you imagine life without mobile phones, cars, CD players, TV, refrigerators, computers, the internet and the World Wide Web, antibiotics, vitamins, anaesthetics, vaccination, heating, pampers, nylon stockings, glue, bar codes, metal detectors, contact lenses, modems, laser printers, digital cameras, gameboys, play stations...? Technology is everywhere and used by everyone in today's society, but how many Europeans suspect that without studies on the structure of the atom, lasers would not exist, and neither would CD players? Most do not realise that most things they couldn't be without have required years of fundamental research . To fill this knowledge gap, the leading Research Organizations in Europe [1], with the support of the research directorate of the European Commission, have joined forces to inform Europeans how technology couldn't be without science, and how science can no longer progress without technology. The project is called...... Sci-Tech - Couldn't be without it! Sci-Tech - Couldn't be without it! invites Europeans to vote online in a survey to identify the top ten technologies they can't live without. It will show them through a dynamic and entertaining Web space where these top technologies really come from, and it will reveal their intimate links with research. Teaching kits will be developed to explain to students how their favourite gadgets actually work, and how a career in science can contribute to inventions that future generations couldn't be without. The results of the survey will be presented as a series of quiz shows live on the Internet during the Science Week, from 4 to 10 November. Sci-tech - Couldn't be without

  18. rOpenSci - open tools for open science

    NASA Astrophysics Data System (ADS)

    Ram, K.

    2013-12-01

    Solving many of the basic and applied challenges in ecology and evolution requires access to large amounts of data, often spanning long spatial and temporal scales. The long-established model where researchers collect and analyze their own data will soon be replaced by one where disparate datasets are brought to bear on both basic and applied problems. As science becomes more data-driven, it faces a whole new set of challenges. Researchers will not only have to maintain expertise in their domains but also learn new skills to curate, retrieve, and analyze these newly available data. In order to fully realize the potential of data-driven science and allow researchers to draw insights from these vast data stores, we need to address challenges associated with all aspects of the research life cycle. To foster and support a new generation of data-driven science, my colleagues and I founded a project called rOpenSci (http://ropensci.org). The project is an integrated effort to build tools and training using Ecology and Evolution as a model community. In this talk I will outline several of the barriers that need to be overcome including better incentive mechanisms for data, training gaps, and lowering technical barriers.

  19. SciDAC-Center for Plasma Edge Simulation

    SciTech Connect

    Chang, Choong Seock

    2012-06-04

    The SciDAC ProtoFSP Center for Plasma Edge Simulation (CPES) [http://www.cims.nyu.edu/cpes/] was awarded to New York University, Courant Institute of Mathematical Sciences in FY 2006. C.S. Chang was the institutional and national project PI. It's mission was 1) to build kinetic simulation code applicable to tokamak edge region including magnetic divertor geometry, 2) to build a computer science framework which can integrate the kinetic code with MHD/fluid codes in multiscale, 3) to conduct scientific research using the developed tools. CPES has built two such edge kinetic codes XGC0 and XGC1, which are still the only working kinetic edge plasma codes capable of including the diverted magnetic field geometry. CPES has also built the code coupling framework EFFIS (End-to-end Framework for Fusion Integrated Simulation), which incubated and used the Adios (www.olcf.ornl.gov/center-projects/adios/) and eSiMon (http://www.olcf.ornl.gov/center-projects/esimmon/) technologies, together with the Kepler technology.

  20. STARtorialist: Astronomy Outreach via Fashion, Sci-Fi, & Pop Culture

    NASA Astrophysics Data System (ADS)

    Rice, Emily L.; Ash, Summer

    2015-01-01

    Astronomical images in the public domain have increasingly been used as inspiration and patterns for clothing, accessories, and home decor. These 'AstroFashion' items are as diverse as DIY projects, handmade and boutique products, mass-produced commercial items, and haute couture. STARtorialist is a Tumblr-based blog that curates the proliferation of these products with the goal of celebrating the beauty of the universe and highlighting the science behind the images. The blog also includes sci-fi, space, and science-related aspects of popular culture. Each post features images and descriptions of the products, and often where/how we found them and/or the people wearing them, with links to the original astronomical images or other relevant science content. The popularity of each post is evident in the number of 'notes', including 'faves' (personal bookmarks) and 'reblogs' (shares with other users). Since launching the blog in December 2013, with an average of one post per day, we've attracted hundreds of followers on Tumblr and Twitter and thousands of notes on Tumblr. We will present our most popular posts and recommend how education, outreach, and press offices can add Tumblr to their social media repertoire.

  1. panMetaDocs, eSciDoc, and DOIDB - an infrastructure for the curation and publication of file-based datasets for 'GFZ Data Services'

    NASA Astrophysics Data System (ADS)

    Ulbricht, Damian; Elger, Kirsten; Bertelmann, Roland; Klump, Jens

    2016-04-01

    With the foundation of DataCite in 2009 and the technical infrastructure installed in the last six years it has become very easy to create citable dataset DOIs. Nowadays, dataset DOIs are increasingly accepted and required by journals in reference lists of manuscripts. In addition, DataCite provides usage statistics [1] of assigned DOIs and offers a public search API to make research data count. By linking related information to the data, they become more useful for future generations of scientists. For this purpose, several identifier systems, as ISBN for books, ISSN for journals, DOI for articles or related data, Orcid for authors, and IGSN for physical samples can be attached to DOIs using the DataCite metadata schema [2]. While these are good preconditions to publish data, free and open solutions that help with the curation of data, the publication of research data, and the assignment of DOIs in one software seem to be rare. At GFZ Potsdam we built a modular software stack that is made of several free and open software solutions and we established 'GFZ Data Services'. 'GFZ Data Services' provides storage, a metadata editor for publication and a facility to moderate minted DOIs. All software solutions are connected through web APIs, which makes it possible to reuse and integrate established software. Core component of 'GFZ Data Services' is an eSciDoc [3] middleware that is used as central storage, and has been designed along the OAIS reference model for digital preservation. Thus, data are stored in self-contained packages that are made of binary file-based data and XML-based metadata. The eSciDoc infrastructure provides access control to data and it is able to handle half-open datasets, which is useful in embargo situations when a subset of the research data are released after an adequate period. The data exchange platform panMetaDocs [4] makes use of eSciDoc's REST API to upload file-based data into eSciDoc and uses a metadata editor [5] to annotate the files

  2. Particles in Action. Study Guide. Unit C2. ZIM-SCI, Zimbabwe Secondary School Science Project.

    ERIC Educational Resources Information Center

    Stocklmayer, Sue

    The Zimbabwe Secondary School Science Project (ZIM-SCI) developed student study guides, corresponding teaching guides, and science kits for a low-cost science course which could be taught during the first 2 years of secondary school without the aid of qualified teachers and conventional laboratories. This ZIM-SCI study guide is a four-part unit…

  3. Close Encounters of the Best Kind: The Latest Sci-Fi

    ERIC Educational Resources Information Center

    Kunzel, Bonnie

    2008-01-01

    Not only is science fiction alive and well--it's flourishing. From the big screen (howdy, Wall-E) to the big books (like Suzanne Collins's The Hunger Games, which has attracted loads of prepublication praise), 2008 has been a great year for sci-fi. Publishers have released truckloads of new sci-fi titles this year, but what's particularly…

  4. The Adequacy of the Science Citation Index (SCI) as an Indicator of International Scientific Activity.

    ERIC Educational Resources Information Center

    Carpenter, Mark P.; Narin, Francis

    1981-01-01

    Presents the results of a study of Science Citation Index (SCI) as a source for developing indicators of international scientific activity. Journal counts based on SCI and British Library Lending Division (BLLD) cataloging records are compared and reference patterns in key journals are described. Eleven references are listed. (JL)

  5. What is Matter? Study Guide. Unit C1. ZIM-SCI, Zimbabwe Secondary School Science Project.

    ERIC Educational Resources Information Center

    Stocklmayer, Sue

    The Zimbabwe Secondary School Science Project (ZIM-SCI) developed student study guides, corresponding teaching guides, and science kits for a low-cost science course which could be taught during the first 2 years of secondary school without the aid of qualified teachers and conventional laboratories. This ZIM-SCI study guide is a two-part unit…

  6. Detection of Abnormal Muscle Activations during Walking Following Spinal Cord Injury (SCI)

    ERIC Educational Resources Information Center

    Wang, Ping; Low, K. H.; McGregor, Alison H.; Tow, Adela

    2013-01-01

    In order to identify optimal rehabilitation strategies for spinal cord injury (SCI) participants, assessment of impaired walking is required to detect, monitor and quantify movement disorders. In the proposed assessment, ten healthy and seven SCI participants were recruited to perform an over-ground walking test at slow walking speeds. SCI…

  7. What Makes Things Happen? Study Guide. Unit B. ZIM-SCI, Zimbabwe Secondary School Science Project.

    ERIC Educational Resources Information Center

    Dube, Peter

    The Zimbabwe Secondary School Science Project (ZIM-SCI) developed student study guides, corresponding teaching guides, and science kits for a low-cost science course which could be taught during the first 2 years of secondary school without the aid of qualified teachers and conventional laboratories. This ZIM-SCI study guide presents activities…

  8. Membrane Targeting and Insertion of the C-Tail Protein SciP.

    PubMed

    Pross, Eva; Soussoula, Lavinia; Seitl, Ines; Lupo, Domenico; Kuhn, Andreas

    2016-10-09

    C-tailed membrane proteins insert into the bilayer post-translationally because the hydrophobic anchor segment leaves the ribosome at the end of translation. Nevertheless, we find here evidence that the targeting of SciP to the membrane of Escherichia coli occurs co-translationally since signal elements in the N-terminal part of the SciP protein sequence are present. Two short hydrophobic sequences were identified that targeted a green fluorescent protein-SciP fusion protein to the membrane involving the signal recognition particle. After targeting, the membrane insertion of SciP is catalyzed by YidC independent of the SecYEG translocase. However, when the C-terminal tail of SciP was extended to 21 aa residues, we found that SecYEG becomes involved and makes its membrane insertion more efficient.

  9. First time experiences using SciPy for computer vision research

    SciTech Connect

    Eads, Damian R; Rosten, Edward J

    2008-01-01

    SciPy is an effective tool suite for prototyping new algorithms. We share some of our experiences using it for the first time to support our research in object detection. SciPy makes it easy to integrate C code, which is essential when algorithms operating on large data sets cannot be vectorized. Python's extensive support for operator overloading makes SciPy's syntax as succinct as its competitors, MATLAB. Octave. and R. The universality of Python. the language in which SciPy was written, gives the researcher access to a broader set of non-numerical libraries to support GUI development. interface with databases, manipulate graph structures, render 3D graphics, unpack binary files, etc. More profoundly, we found it easy to rework research code written with SciPy into a production application, deployable on numerous platforms.

  10. Data Sharing and Publication Using the SciDrive Service

    NASA Astrophysics Data System (ADS)

    Mishin, D.; Medvedev, D.; Szalay, A. S.; Plante, R.; Graham, M.

    2014-05-01

    Despite all the progress made during the last years in the field of cloud data storage, the problem of fast and reliable data storage for the scientific community still remains open. The SciDrive project meets the need for a free open-source scientific data publishing platform. Having the primary target audience of astronomers as the largest data producers, the platform however is not bound to any scientific domain and can be used by different communities. Our current installation provides a free and safe storage platform for scientists to publish their data and share it with the community with the simplicity of Dropbox. The system allows service providers to harvest from the files and derive their broader context in a fairly automated fashion. Collecting various scientific data files in a single location or multiple connected sites allows building an intelligent system of metadata extractors. Our system is aimed at simplifying the cataloging and processing of large file collections for the long tail of scientific data. We propose an extensible plugin architecture for automatic metadata extraction and storage. The current implementation targets some of the data formats commonly used by the astronomy communities, including FITS, ASCII and Excel tables, TIFF images, and YT simulations data archives. Along with generic metadata, format-specific metadata is also processed. For example, basic information about celestial objects is extracted from FITS files and TIFF images, if present. This approach makes the simple BLOB storage a smart system providing access to various data in its own representation, such as a database for files containing tables, or providing additional search and access features such as full-text search, image pyramids or thumbnails creation, simulation dataset id extractor for fast search. A 100TB implementation has just been put into production at Johns Hopkins University.

  11. Data publication and sharing using the SciDrive service

    NASA Astrophysics Data System (ADS)

    Mishin, Dmitry; Medvedev, D.; Szalay, A. S.; Plante, R. L.

    2014-01-01

    Despite the last years progress in scientific data storage, still remains the problem of public data storage and sharing system for relatively small scientific datasets. These are collections forming the “long tail” of power log datasets distribution. The aggregated size of the long tail data is comparable to the size of all data collections from large archives, and the value of data is significant. The SciDrive project's main goal is providing the scientific community with a place to reliably and freely store such data and provide access to it to broad scientific community. The primary target audience of the project is astoromy community, and it will be extended to other fields. We're aiming to create a simple way of publishing a dataset, which can be then shared with other people. Data owner controls the permissions to modify and access the data and can assign a group of users or open the access to everyone. The data contained in the dataset will be automaticaly recognized by a background process. Known data formats will be extracted according to the user's settings. Currently tabular data can be automatically extracted to the user's MyDB table where user can make SQL queries to the dataset and merge it with other public CasJobs resources. Other data formats can be processed using a set of plugins that upload the data or metadata to user-defined side services. The current implementation targets some of the data formats commonly used by the astronomy communities, including FITS, ASCII and Excel tables, TIFF images, and YT simulations data archives. Along with generic metadata, format-specific metadata is also processed. For example, basic information about celestial objects is extracted from FITS files and TIFF images, if present. A 100TB implementation has just been put into production at Johns Hopkins University. The system features public data storage REST service supporting VOSpace 2.0 and Dropbox protocols, HTML5 web portal, command-line client and Java

  12. Effects of Early Acute Care on Autonomic Outcomes in SCI: Bedside to Bench and Back

    DTIC Science & Technology

    2014-10-30

    spinal cord injury (SCI), but evidence-based protocols are needed. Optimal early treatment and management of SCI has not been established in clinical...and electronic medical records of SCI patients We have held meetings with the SFGH spinal cord injury clinicians and have established methods for...of  blood  pressure  in  the  rats  after   spinal  cord   injury  at  the  high  thoracic  level  using  the

  13. Evidence of a wide spectrum of cardiac involvement due to ACAD9 mutations: Report on nine patients.

    PubMed

    Dewulf, Joseph P; Barrea, Catherine; Vincent, Marie-Françoise; De Laet, Corinne; Van Coster, Rudy; Seneca, Sara; Marie, Sandrine; Nassogne, Marie-Cécile

    2016-07-01

    Acyl-CoA dehydrogenase 9 (ACAD9) is a mitochondrial protein involved in oxidative phosphorylation complex I biogenesis. This protein also exhibits acyl-CoA dehydrogenase (ACAD) activity. ACAD9-mutated patients have been reported to suffer from primarily heart, muscle, liver, and nervous system disorders. ACAD9 mutation is suspected in cases of elevated lactic acid levels combined with complex I deficiency, and confirmed by ACAD9 gene analysis. At least 18 ACAD9-mutated patients have previously been reported, usually displaying severe cardiac involvement. We retrospectively studied nine additional patients from three unrelated families with a wide spectrum of cardiac involvement between the families as well as the patients from the same families. All patients exhibited elevated lactate levels. Deleterious ACAD9 mutations were identified in all patients except one for whom it was not possible to recover DNA. To our knowledge, this is one of the first reports on isolated mild ventricular hypertrophy due to ACAD9 mutation in a family with moderate symptoms during adolescence. This report also confirms that dilated cardiomyopathy may occur in conjunction with ACAD9 mutation and that some patients may respond clinically to riboflavin treatment. Of note, several patients suffered from patent ductus arteriosus (PDA), with one exhibiting a complex congenital heart defect. It is yet unknown whether these cardiac manifestations were related to ACAD9 mutation. In conclusion, this disorder should be suspected in the presence of lactic acidosis, complex I deficiency, and any cardiac involvement, even mild.

  14. Sci-Hub: What Librarians Should Know and Do about Article Piracy.

    PubMed

    Hoy, Matthew B

    2017-01-01

    The high cost of journal articles has driven many researchers to turn to a new way of getting access: "pirate" article sites. Sci-Hub, the largest and best known of these sites, currently offers instant access to more than 58 million journal articles. Users attracted by the ease of use and breadth of the collection may not realize that these articles are often obtained using stolen credentials and downloading them may be illegal. This article will briefly describe Sci-Hub and how it works, the legal and ethical issues it raises, and the problems it may cause for librarians. Librarians should be aware of Sci-Hub and the ways it may change their patrons' expectations. They should also understand the risks Sci-Hub can pose to their patrons and their institutions.

  15. 76 FR 10395 - BreconRidge Manufacturing Solutions, Now Known as Sanmina-SCI Corporation, Division...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-24

    ... Corporation, Division Optoelectronic and Microelectronic Design and Manufacturing, a Subsidiary of Sanmina-SCI Corporation, Including On- Site Leased Workers From Kelly Services, Penski, Inc., and Whitney Enterprises... Corporation, Division Optoelectronic and Microelectronic Design and Manufacturing, a subsidiary of...

  16. Complementary use of the SciSearch database for improved biomedical information searching.

    PubMed Central

    Brown, C M

    1998-01-01

    The use of at least two complementary online biomedical databases is generally considered critical for biomedical scientists seeking to keep fully abreast of recent research developments as well as to retrieve the highest number of relevant citations possible. Although the National Library of Medicine's MEDLINE is usually the database of choice, this paper illustrates the benefits of using another database, the Institute for Scientific Information's SciSearch, when conducting a biomedical information search. When a simple query about red wine consumption and coronary artery disease was posed simultaneously in both MEDLINE and SciSearch, a greater number of relevant citations were retrieved through SciSearch. This paper also provides suggestions for carrying out a comprehensive biomedical literature search in a rapid and efficient manner by using SciSearch in conjunction with MEDLINE. PMID:9549014

  17. SciServer Compute brings Analysis to Big Data in the Cloud

    NASA Astrophysics Data System (ADS)

    Raddick, Jordan; Medvedev, Dmitry; Lemson, Gerard; Souter, Barbara

    2016-06-01

    SciServer Compute uses Jupyter Notebooks running within server-side Docker containers attached to big data collections to bring advanced analysis to big data "in the cloud." SciServer Compute is a component in the SciServer Big-Data ecosystem under development at JHU, which will provide a stable, reproducible, sharable virtual research environment.SciServer builds on the popular CasJobs and SkyServer systems that made the Sloan Digital Sky Survey (SDSS) archive one of the most-used astronomical instruments. SciServer extends those systems with server-side computational capabilities and very large scratch storage space, and further extends their functions to a range of other scientific disciplines.Although big datasets like SDSS have revolutionized astronomy research, for further analysis, users are still restricted to downloading the selected data sets locally - but increasing data sizes make this local approach impractical. Instead, researchers need online tools that are co-located with data in a virtual research environment, enabling them to bring their analysis to the data.SciServer supports this using the popular Jupyter notebooks, which allow users to write their own Python and R scripts and execute them on the server with the data (extensions to Matlab and other languages are planned). We have written special-purpose libraries that enable querying the databases and other persistent datasets. Intermediate results can be stored in large scratch space (hundreds of TBs) and analyzed directly from within Python or R with state-of-the-art visualization and machine learning libraries. Users can store science-ready results in their permanent allocation on SciDrive, a Dropbox-like system for sharing and publishing files. Communication between the various components of the SciServer system is managed through SciServer‘s new Single Sign-on Portal.We have created a number of demos to illustrate the capabilities of SciServer Compute, including Python and R scripts

  18. Novel Target for Ameliorating Pain and Other Problems after SCI: Spontaneous Activity in Nociceptors

    DTIC Science & Technology

    2014-10-01

    Pain gests that interventions preferentially targeting nociceptive pri- mary afferent neurons, such as antagonists of Nav1.8 (Jarvis et al., 2007) or... pain afflicts a majority of SCI patients (Dijkers et al., 2009). This pain is typically divided into two major classes, nociceptive and neuropathic...Bryce et al., 2012). The largest prospective pain study of patients with traumatic SCI found that moderate-to-severe nociceptive and neuro- pathic pain

  19. SCI Survey to Determine Pressure Ulcer Vulnerability in the Outpatient Population

    DTIC Science & Technology

    2011-10-01

    include an analysis of osteomyelitis diagnosis and treatment with plans to submit a proposed algorithm to the SCI-QUERI‘ (SCI-Quality Enhancement...34, is there independent ability to % SERVICE CONNECTED BOWEL PRGM LOC # HRS PER TREATMENT BLADDER CONTINENT BLADDER MANAGEMENT INDEWELLING CATHETER...ANEMIA AUTONOMIC DYSREFLEXIA DIABETES1 DIABETES2 HETEROTOPIC OSSIFICATION HYPERTHYROID HYPOTHYROID OSTEOMYELITIS PAIN LEVEL 1-10 TOBACCO USE PAST

  20. FES-Rowing versus Zoledronic Acid to Improve Bone Health in SCI

    DTIC Science & Technology

    2013-10-01

    SCI, although the risk is high in this population of osteoporosis -related bone fracture. This study aims to learn if the severe osteoporosis in lower... Osteoporosis , FES-rowing, zoledronic acid, exercise, bone health 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT 18. NUMBER OF PAGES 19a...Introduction Serious spinal cord injury (SCI) causes osteoporosis in the lower extremities, significantly increasing the risk of bone fracture in

  1. Mid-year Status of MESSENGER SciBox Science Planning and Commanding

    NASA Astrophysics Data System (ADS)

    Nguyen, L.; Choo, T. H.; Steele, R. J.; Lucks, M.; Nair, H.; Perry, M. E.; Anderson, B. J.; Berman, A. F.; Solomon, S. C.

    2011-12-01

    More than halfway into its primary orbital mission, MESSENGER has successfully exploited the SciBox planning and commanding system to automate science observation scheduling and command generation for its full instrument suite, as well as its radio-frequency communication and guidance and control systems. MESSENGER's SciBox software coordinates instrument observations to determine the optimal conflict-free science schedule for the entire orbital mission and generates weekly command sequences for submission to mission operations. SciBox maximizes science return by filling all available observing opportunities and fully utilizing onboard storage and downlink bandwidth. As of four months into its one-year orbital mission, MESSENGER SciBox had scheduled the acquisition and downlink of nearly 40,000 images and comparable data sets from the spacecraft's six other instruments. The flexibility of MESSENGER SciBox allows for rapid re-optimization of schedules in the event of unforeseen circumstances. It has also allowed the science and planning teams to analyze rapidly the effects of modifying operational parameters and adding new observations. Within two hours, the entire mission can be re-optimized, schedules and command sequences generated, and a full set of plots and reports produced. The effects on resource usage, observational coverage, and compliance with operational constraints may be quickly assessed. This rapid turnaround ensures that optimal schedules are produced regardless of circumstances. We present an overview of the MESSENGER SciBox design and its operation.

  2. Targeting Translational Successes through CANSORT-SCI: Using Pet Dogs To Identify Effective Treatments for Spinal Cord Injury.

    PubMed

    Moore, Sarah A; Granger, Nicolas; Olby, Natasha J; Spitzbarth, Ingo; Jeffery, Nick D; Tipold, Andrea; Nout-Lomas, Yvette S; da Costa, Ronaldo C; Stein, Veronika M; Noble-Haeusslein, Linda J; Blight, Andrew R; Grossman, Robert G; Basso, D Michele; Levine, Jonathan M

    2017-03-22

    Translation of therapeutic interventions for spinal cord injury (SCI) from laboratory to clinic has been historically challenging, highlighting the need for robust models of injury that more closely mirror the human condition. The high prevalence of acute, naturally occurring SCI in pet dogs provides a unique opportunity to evaluate expeditiously promising interventions in a population of animals that receive diagnoses and treatment clinically in a manner similar to persons with SCI, while adhering to National Institutes of Health guidelines for scientific rigor and transparent reporting. In addition, pet dogs with chronic paralysis are often maintained long-term by their owners, offering a similarly unique population for study of chronic SCI. Despite this, only a small number of studies have used the clinical dog model of SCI. The Canine Spinal Cord Injury Consortium (CANSORT-SCI) was recently established by a group of veterinarians and basic science researchers to promote the value of the canine clinical model of SCI. The CANSORT-SCI group held an inaugural meeting November 20 and 21, 2015 to evaluate opportunities and challenges to the use of pet dogs in SCI research. Key challenges identified included lack of familiarity with the model among nonveterinary scientists and questions about how and where in the translational process the canine clinical model would be most valuable. In light of these, we review the natural history, outcome, and available assessment tools associated with canine clinical SCI with emphasis on their relevance to human SCI and the translational process.

  3. Impact of Health Behaviors and Health Management on Employment After SCI: Psychological Health and Health Management

    PubMed Central

    Meade, Michelle A.; Krause, James S.

    2016-01-01

    Objective: The purpose of this study was to examine the relationship between employment and psychological health and health management as described by individuals with spinal cord injury (SCI) who were employed at least once following injury. Methods: A qualitative approach used 6 focus groups at 2 sites with 44 participants who were at least 10 years post SCI. All had been employed at some point since injury. Heterogeneous and homogeneous groups were delineated based on specific characteristics, such as education, gender, or race. Group sessions followed a semi-structured interview format with questions about personal, environmental, and policy related factors influencing employment following SCI. All group sessions were recorded, transcribed, and coded into conceptual categories to identify topics, themes, and patterns. Inferences were drawn about their meaning. NVivo 10 software using the constant comparative method was used for data analysis. Results: Narratives discussed the relationship between employment and psychological and emotional health and health management. Four themes were identified: (1) adjustment and dealing with emotional reactions, (2) gaining self-confidence, (3) preventing burnout, and (4) attitudes and perspectives. Most themes reflected issues that varied based on severity of injury as well as stage of employment. Conclusions: Individuals with SCI who are successful in working following injury must determine how to perform the behaviors necessary to manage their health and prevent emotional or physical complications. The emotional consequences of SCI must be recognized and addressed and specific behaviors enacted in order to optimize employment outcomes.

  4. Biomaterial scaffolds used for the regeneration of spinal cord injury (SCI).

    PubMed

    Kim, Moonhang; Park, So Ra; Choi, Byung Hyune

    2014-11-01

    This review presents a summary of various types of scaffold biomaterials used alone or together with therapeutic drugs and cells to regenerate spinal cord injury (SCI). The inhibitory environment and loss of axonal connections after SCI give rise to critical obstacles to regeneration of lost tissues and neuronal functions. Biomaterial scaffolds can provide a bridge to connect lost tissues, an adhesion site for implanted or host cells, and sustained release of therapeutic drugs in the injured spinal cord. In addition, they not only provide a structural platform, but can play active roles by inhibiting apoptosis of cells, inflammation and scar formation, and inducing neurogenesis, axonal growth and angiogenesis. Many synthetic and natural biomaterial scaffolds have been extensively investigated and tested in vitro and in animal SCI models for these purposes. We summarized the literature on the biomaterials commonly used for spinal cord regeneration in terms of historical backgrounds and current approaches.

  5. Charged-Current Neutral Pion production at SciBooNE

    SciTech Connect

    Catala-Perez, J.; /Valencia U., IFIC

    2009-10-01

    SciBooNE, located in the Booster Neutrino Beam at Fermilab, collected data from June 2007 to August 2008 to accurately measure muon neutrino and anti-neutrino cross sections on carbon below 1 GeV neutrino energy. SciBooNE is studying charged current interactions. Among them, neutral pion production interactions will be the focus of this poster. The experimental signature of neutrino-induced neutral pion production is constituted by two electromagnetic cascades initiated by the conversion of the {pi}{sup 0} decay photons, with an additional muon in the final state for CC processes. In this poster, I will present how we reconstruct and select charged-current muon neutrino interactions producing {pi}{sup 0}'s in SciBooNE.

  6. Implementing Connected Component Labeling as a User Defined Operator for SciDB

    NASA Technical Reports Server (NTRS)

    Oloso, Amidu; Kuo, Kwo-Sen; Clune, Thomas; Brown, Paul; Poliakov, Alex; Yu, Hongfeng

    2016-01-01

    We have implemented a flexible User Defined Operator (UDO) for labeling connected components of a binary mask expressed as an array in SciDB, a parallel distributed database management system based on the array data model. This UDO is able to process very large multidimensional arrays by exploiting SciDB's memory management mechanism that efficiently manipulates arrays whose memory requirements far exceed available physical memory. The UDO takes as primary inputs a binary mask array and a binary stencil array that specifies the connectivity of a given cell to its neighbors. The UDO returns an array of the same shape as the input mask array with each foreground cell containing the label of the component it belongs to. By default, dimensions are treated as non-periodic, but the UDO also accepts optional input parameters to specify periodicity in any of the array dimensions. The UDO requires four stages to completely label connected components. In the first stage, labels are computed for each subarray or chunk of the mask array in parallel across SciDB instances using the weighted quick union (WQU) with half-path compression algorithm. In the second stage, labels around chunk boundaries from the first stage are stored in a temporary SciDB array that is then replicated across all SciDB instances. Equivalences are resolved by again applying the WQU algorithm to these boundary labels. In the third stage, relabeling is done for each chunk using the resolved equivalences. In the fourth stage, the resolved labels, which so far are "flattened" coordinates of the original binary mask array, are renamed with sequential integers for legibility. The UDO is demonstrated on a 3-D mask of O(1011) elements, with O(108) foreground cells and O(106) connected components. The operator completes in 19 minutes using 84 SciDB instances.

  7. Bringing the SciBar detector to the booster neutrino beam

    SciTech Connect

    Aguilar-Arevalo, A.A.; Alcaraz, J.; Andringa, S.; Brice, S.J.; Brown, B.C.; Bugel, L.; Catala, J.; Cervera, A.; Conrad, J.M.; Couce, E.; Dore, U.; Espinal, X.; Finley, D.A.; Gomez-Cadenas, J.J.; Hayato, Y.; Hiraide, K.; Ishii, T.; Jover, G.; Kobilarcik, T.; Kurimoto, Y.; Kurosawa, Y.; /Columbia U. /Fermilab /KEK, Tsukuba /Barcelona, IFAE /Tokyo U., ICRR /Valencia U., IFIC /Kyoto U. /Los Alamos /Louisiana State U. /Stratton Mountain Sch. /Rome U. /INFN, Rome /Colorado U.

    2006-01-01

    This document presents the physics case for bringing SciBar, the fully active, finely segmented tracking detector at KEK, to the FNAL Booster Neutrino Beam (BNB) line. This unique opportunity arose with the termination of K2K beam operations in 2005. At that time, the SciBar detector became available for use in other neutrino beam lines, including the BNB, which has been providing neutrinos to the MiniBooNE experiment since late 2002. The physics that can be done with SciBar/BNB can be put into three categories, each involving several measurements. First are neutrino cross section measurements which are interesting in their own right, including analyses of multi-particle final states, with unprecedented statistics. Second are measurements of processes that represent the signal and primary background channels for the upcoming T2K experiment. Third are measurements which improve existing or planned MiniBooNE analyses and the understanding of the BNB, both in neutrino and antineutrino mode. For each of these proposed measurements, the SciBar/BNB combination presents a unique opportunity or will significantly improve upon current or near-future experiments for several reasons. First, the fine granularity of SciBar allows detailed reconstruction of final states not possible with the MiniBooNE detector. Additionally, the BNB neutrino energy spectrum is a close match to the expected T2K energy spectrum in a region where cross sections are expected to vary dramatically with energy. As a result, the SciBar/BNB combination will provide cross-section measurements in an energy range complementary to MINERvA and complete the knowledge of neutrino cross sections over the entire energy range of interest to the upcoming off-axis experiments.

  8. CitSci.org: A New Model for Managing, Documenting, and Sharing Citizen Science Data.

    PubMed

    Wang, Yiwei; Kaplan, Nicole; Newman, Greg; Scarpino, Russell

    2015-10-01

    Citizen science projects have the potential to advance science by increasing the volume and variety of data, as well as innovation. Yet this potential has not been fully realized, in part because citizen science data are typically not widely shared and reused. To address this and related challenges, we built CitSci.org (see www.citsci.org), a customizable platform that allows users to collect and generate diverse datasets. We hope that CitSci.org will ultimately increase discoverability and confidence in citizen science observations, encouraging scientists to use such data in their own scientific research.

  9. Final Report for DOE Project: Portal Web Services: Support of DOE SciDAC Collaboratories

    SciTech Connect

    Mary Thomas, PI; Geoffrey Fox, Co-PI; Gannon, D; Pierce, M; Moore, R; Schissel, D; Boisseau, J

    2007-10-01

    Grid portals provide the scientific community with familiar and simplified interfaces to the Grid and Grid services, and it is important to deploy grid portals onto the SciDAC grids and collaboratories. The goal of this project is the research, development and deployment of interoperable portal and web services that can be used on SciDAC National Collaboratory grids. This project has four primary task areas: development of portal systems; management of data collections; DOE science application integration; and development of web and grid services in support of the above activities.

  10. SciServer: An Online Collaborative Environment for Big Data in Research and Education

    NASA Astrophysics Data System (ADS)

    Raddick, Jordan; Souter, Barbara; Lemson, Gerard; Taghizadeh-Popp, Manuchehr

    2017-01-01

    For the past year, SciServer Compute (http://compute.sciserver.org) has offered access to big data resources running within server-side Docker containers. Compute has allowed thousands of researchers to bring advanced analysis to big datasets like the Sloan Digital Sky Survey and others, while keeping the analysis close to the data for better performance and easier read/write access. SciServer Compute is just one part of the SciServer system being developed at Johns Hopkins University, which provides an easy-to-use collaborative research environment for astronomy and many other sciences.SciServer enables these collaborative research strategies using Jupyter notebooks, in which users can write their own Python and R scripts and execute them on the same server as the data. We have written special-purpose libraries for querying, reading, and writing data. Intermediate results can be stored in large scratch space (hundreds of TBs) and analyzed directly from within Python or R with state-of-the-art visualization and machine learning libraries. Users can store science-ready results in their permanent allocation on SciDrive, a Dropbox-like system for sharing and publishing files.SciServer Compute’s virtual research environment has grown with the addition of task management and access control functions, allowing collaborators to share both data and analysis scripts securely across the world. These features also open up new possibilities for education, allowing instructors to share datasets with students and students to write analysis scripts to share with their instructors. We are leveraging these features into a new system called “SciServer Courseware,” which will allow instructors to share assignments with their students, allowing students to engage with big data in new ways.SciServer has also expanded to include more datasets beyond the Sloan Digital Sky Survey. A part of that growth has been the addition of the SkyQuery component, which allows for simple, fast

  11. GeoSciML version 3: A GML application for geologic information

    NASA Astrophysics Data System (ADS)

    International Union of Geological Sciences., I. C.; Richard, S. M.

    2011-12-01

    After 2 years of testing and development, XML schema for GeoSciML version 3 are now ready for application deployment. GeoSciML draws from many geoscience data modelling efforts to establish a common suite of feature types to represent information associated with geologic maps (materials, structures, and geologic units) and observations including structure data, samples, and chemical analyses. After extensive testing and use case analysis, in December 2008 the CGI Interoperability Working Group (IWG) released GeoSciML 2.0 as an application schema for basic geological information. GeoSciML 2.0 is in use to deliver geologic data by the OneGeology Europe portal, the Geological Survey of Canada Groundwater Information Network (wet GIN), and the Auscope Mineral Resources portal. GeoSciML to version 3.0 is updated to OGC Geography Markup Language v3.2, re-engineered patterns for association of element values with controlled vocabulary concepts, incorporation of ISO19156 Observation and Measurement constructs for representing numeric and categorical values and for representing analytical data, incorporation of EarthResourceML to represent mineral occurrences and mines, incorporation of the GeoTime model to represent GSSP and stratigraphic time scale, and refactoring of the GeoSciML namespace to follow emerging ISO practices for decoupling of dependencies between standardized namespaces. These changes will make it easier for data providers to link to standard vocabulary and registry services. The depth and breadth of GeoSciML remains largely unchanged, covering the representation of geologic units, earth materials and geologic structures. ISO19156 elements and patterns are used to represent sampling features such as boreholes and rock samples, as well as geochemical and geochronologic measurements. Geologic structures include shear displacement structures (brittle faults and ductile shears), contacts, folds, foliations, lineations and structures with no preferred

  12. Cloning and functional characterization of ACAD-9, a novel member of human acyl-CoA dehydrogenase family.

    PubMed

    Zhang, Jia; Zhang, Weiping; Zou, Dajin; Chen, Guoyou; Wan, Tao; Zhang, Minghui; Cao, Xuetao

    2002-10-04

    Acyl-CoA dehydrogenases (ACADs) are a family of mitochondrial enzymes catalyzing the initial rate-limiting step in the beta-oxidation of fatty acyl-CoA. The reaction provides main source of energy for human heart and skeletal muscle. Eight human ACADs have been described. Deficiency of these enzymes, especially very long-chain acyl-CoA dehydrogenase (VLCAD), usually leads to severe human organic diseases, such as sudden death in infancy, infantile cardiomyopathy (CM), hypoketotic hypoglycemia, or hepatic dysfunction. By large-scale random sequencing, we identified a novel homolog of ACADs from human dendritic cell (DC) cDNA library. It contains an open reading frame (ORF) of 1866bp, which encodes a 621 amino acid protein. It shares approximately 47% amino acid identity and 65% similarity with human VLCAD. So, the novel molecule is named as acyl-CoA dehydrogenase-9 (ACAD-9), the ninth member of ACADs. The new gene consists of 18 exons and 17 introns, and is mapped to chromosome 3q26. It contains the two signatures shared by all members of the ACADs. ACAD-9 mRNA is ubiquitously expressed in most normal human tissues and cancer cell lines with high level of expression in heart, skeletal muscles, brain, kidney, and liver. Enzymatic assay proved that the recombinant ACAD-9 protein has the dehydrogenase activity on palmitoyl-coenzyme A (C16:0) and stearoyl-coenzyme A (C18:0). Our results indicate that ACAD-9 is a novel member of ACADs.

  13. Sleep-Disordered Breathing in Chronic SCI: A Randomized Controlled Trial of Treatment Impact on Cognition, Quality of Life, and Cardiovascular Disease

    DTIC Science & Technology

    2014-10-01

    AWARD NUMBER: W81XWH-13-1-0479 TITLE: Sleep-Disordered Breathing in Chronic SCI: A...5a. CONTRACT NUMBER Sleep-Disordered Breathing in Chronic SCI: A Randomized Controlled Trial of Treatment Impact on Cognition...SCI. In this prospective randomized controlled trial, we will objectively measure sleep disordered breathing (SDB) in chronic SCI patients using

  14. Scalable Earth-observation Analytics for Geoscientists: Spacetime Extensions to the Array Database SciDB

    NASA Astrophysics Data System (ADS)

    Appel, Marius; Lahn, Florian; Pebesma, Edzer; Buytaert, Wouter; Moulds, Simon

    2016-04-01

    Today's amount of freely available data requires scientists to spend large parts of their work on data management. This is especially true in environmental sciences when working with large remote sensing datasets, such as obtained from earth-observation satellites like the Sentinel fleet. Many frameworks like SpatialHadoop or Apache Spark address the scalability but target programmers rather than data analysts, and are not dedicated to imagery or array data. In this work, we use the open-source data management and analytics system SciDB to bring large earth-observation datasets closer to analysts. Its underlying data representation as multidimensional arrays fits naturally to earth-observation datasets, distributes storage and computational load over multiple instances by multidimensional chunking, and also enables efficient time-series based analyses, which is usually difficult using file- or tile-based approaches. Existing interfaces to R and Python furthermore allow for scalable analytics with relatively little learning effort. However, interfacing SciDB and file-based earth-observation datasets that come as tiled temporal snapshots requires a lot of manual bookkeeping during ingestion, and SciDB natively only supports loading data from CSV-like and custom binary formatted files, which currently limits its practical use in earth-observation analytics. To make it easier to work with large multi-temporal datasets in SciDB, we developed software tools that enrich SciDB with earth observation metadata and allow working with commonly used file formats: (i) the SciDB extension library scidb4geo simplifies working with spatiotemporal arrays by adding relevant metadata to the database and (ii) the Geospatial Data Abstraction Library (GDAL) driver implementation scidb4gdal allows to ingest and export remote sensing imagery from and to a large number of file formats. Using added metadata on temporal resolution and coverage, the GDAL driver supports time-based ingestion of

  15. [Analysis of the citation of the articles published in National Journal of Andrology by SCI periodicals from 2002 to 2008].

    PubMed

    Huang, Hai

    2009-03-01

    Science Citation Index (SCI) is one of the world's most important and influential information retrieval systems. Today Web of Science covers over 9000 international and regional journals and book series in every field of natural sciences, social sciences, and arts and humanities. More and more Chinese periodicals have been cited by SCI. This paper briefly introduces the SCI database and its selection process and analyzes the citation of the articles published in National Journal of Andrology (NJA) by SCI journals from 2002 to 2008, aiming to provide some information for the internationalization of NJA.

  16. What Makes Things Happen? Teacher's Guide. Unit B. ZIM-SCI, Zimbabwe Secondary School Science Project.

    ERIC Educational Resources Information Center

    Dube, Peter

    The Zimbabwe Secondary School Science Project (ZIM-SCI) developed student study guides, corresponding teaching guides, and science kits for a low-cost science course which could be taught during the first 2 years of secondary school without the aid of qualified teachers and conventional laboratories. This teaching guide, designed to be read in…

  17. Particles in Action. Teacher's Guide. Unit C2. ZIM-SCI, Zimbabwe Secondary School Science Project.

    ERIC Educational Resources Information Center

    Stocklmayer, Sue

    The Zimbabwe Secondary School Science Project (ZIM-SCI) developed student study guides, corresponding teaching guides, and science kits for a low-cost science course which could be taught during the first 2 years of secondary school without the aid of qualified teachers and conventional laboratories. This teaching guide, designed to be read in…

  18. Purification and biochemical characterisation of human and murine stem cell inhibitors (SCI).

    PubMed

    Graham, G J; Freshney, M G; Donaldson, D; Pragnell, I B

    1992-01-01

    We have recently characterised an inhibitor of haemopoietic stem cell proliferation (SCI/MIP-1 alpha) and report here on its purification and initial biological and biochemical characterisation. The activity can be detected by direct addition to the CFU-A stem cell assay and this simple test for inhibitory activity has greatly facilitated the purification of the molecule. The purification involves a combination of Mono Q ion exchange chromatography, heparin-sepharose affinity chromatography and Blue Sepharose affinity chromatography. The purified stem cell inhibitor is an 8 kD peptide which is identical to the previously described peptide macrophage inflammatory protein 1 alpha. The peptide has a natural tendency to form large self-aggregates and appears, in physiological buffers, to have a native molecular weight of around 90 kD. SCI is a heat stable, protease sensitive protein which is half maximally active at between 10 and 25 pM in the CFU-A assay. The self-aggregates can be disrupted by dilute solutions of acetic acid and it appears that disruption increases the specific activity of SCI preparations. We also report the characterisation of the human homologue of the stem cell inhibitor (human SCI/MIP-1 alpha) which is 74% identical to murine MIP-1 alpha and which shares all the above features of the murine inhibitor.

  19. National Computational Infrastructure for Lattice Gauge Theory SciDAC-2 Closeout Report Indiana University Component

    SciTech Connect

    Gottlieb, Steven Arthur; DeTar, Carleton; Tousaint, Doug

    2014-07-24

    This is the closeout report for the Indiana University portion of the National Computational Infrastructure for Lattice Gauge Theory project supported by the United States Department of Energy under the SciDAC program. It includes information about activities at Indian University, the University of Arizona, and the University of Utah, as those three universities coordinated their activities.

  20. Cross section analyses in MiniBooNE and SciBooNE experiments

    SciTech Connect

    Katori, Teppei

    2015-05-15

    The MiniBooNE experiment (2002-2012) and the SciBooNE experiment (2007-2008) are modern high statistics neutrino experiments, and they developed many new ideas in neutrino cross section analyses. In this note, I discuss selected topics of these analyses.

  1. SciJourn is magic: construction of a science journalism community of practice

    NASA Astrophysics Data System (ADS)

    Nicholas, Celeste R.

    2016-01-01

    This article is the first to describe the discoursal construction of an adolescent community of practice (CoP) in a non-school setting. CoPs can provide optimal learning environments. The adolescent community centered around science journalism and positioned itself dichotomously in relationship to school literacy practices. The analysis focuses on recordings from a panel-style research interview from an early implementation of the Science Literacy Through Science Journalism (SciJourn) project. Researchers trained high school students participating in a youth development program to write science news articles. Students engaged in the authentic practices of professional science journalists, received feedback from a professional editor, and submitted articles for publication. I used a fine-grained critical discourse analysis of genre, discourse, and style to analyze student responses about differences between writing in SciJourn and in school. Students described themselves as agentic in SciJourn and passive in school, using an academic writing discourse of deficit to describe schooling experiences. They affiliated with and defined a SciJourn CoP, constructing positive journalistic identities therein. Educators are encouraged to develop similar CoPs. The discursive features presented may be used to monitor the development of communities of practice in a variety of settings.

  2. SCI Survey to Determine Pressure Ulcer Vulnerability in the Outpatient Population

    DTIC Science & Technology

    2012-10-01

    2009. Patients with or without pressure ulcers were included. Patients with SCI due to terminal disease, multiple sclerosis of amyotrophic lateral ... sclerosis were excluded. A data extraction tool was used to compile information known to impact the development of pressure ulcers in persons with

  3. SciEthics Interactive: Science and Ethics Learning in a Virtual Environment

    ERIC Educational Resources Information Center

    Nadolny, Larysa; Woolfrey, Joan; Pierlott, Matthew; Kahn, Seth

    2013-01-01

    Learning in immersive 3D environments allows students to collaborate, build, and interact with difficult course concepts. This case study examines the design and development of the TransGen Island within the SciEthics Interactive project, a National Science Foundation-funded, 3D virtual world emphasizing learning science content in the context of…

  4. Performance Engineering Research Institute SciDAC-2 Enabling Technologies Institute Final Report

    SciTech Connect

    Lucas, Robert

    2013-04-20

    Enhancing the performance of SciDAC applications on petascale systems had high priority within DOE SC at the start of the second phase of the SciDAC program, SciDAC-2, as it continues to do so today. Achieving expected levels of performance on high-end computing (HEC) systems is growing ever more challenging due to enormous scale, increasing architectural complexity, and increasing application complexity. To address these challenges, the University of Southern California?s Information Sciences Institute organized the Performance Engineering Research Institute (PERI). PERI implemented a unified, tripartite research plan encompassing: (1) performance modeling and prediction; (2) automatic performance tuning; and (3) performance engineering of high profile applications. Within PERI, USC?s primary research activity was automatic tuning (autotuning) of scientific software. This activity was spurred by the strong user preference for automatic tools and was based on previous successful activities such as ATLAS, which automatically tuned components of the LAPACK linear algebra library, and other recent work on autotuning domain-specific libraries. Our other major component was application engagement, to which we devoted approximately 30% of our effort to work directly with SciDAC-2 applications. This report is a summary of the overall results of the USC PERI effort.

  5. Evaluating soil organic C sequestration in the Cotton Belt with the soil conditioning index (SCI)

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Simulation models that are sensitive to management, edaphic factors, and climate could provide insightful probes of how land owners and producers might be able to sequester soil organic C and engage in emerging carbon markets. We used the soil conditioning index (SCI) embedded in the RUSLE2 model t...

  6. SciTech Clubs for Girls. [Final report], September 1, 1991--April 30, 1994

    SciTech Connect

    Malamud, E.; Diaz, O.; Cox, J.

    1994-12-31

    The program of SciTech Clubs for Girls and its progress are described. This is a program that promotes the learning of science and mathematics by girls in the age range of 9 to 13 years through the process of building exhibits and learning from local professionals. A list of exhibits and a critique of the program are given.

  7. Microlithography and resist technology information at your fingertips via SciFinder

    NASA Astrophysics Data System (ADS)

    Konuk, Rengin; Macko, John R.; Staggenborg, Lisa

    1997-07-01

    Finding and retrieving the information you need about microlithography and resist technology in a timely fashion can make or break your competitive edge in today's business environment. Chemical Abstracts Service (CAS) provides the most complete and comprehensive database of the chemical literature in the CAplus, REGISTRY, and CASREACT files including 13 million document references, 15 million substance records and over 1.2 million reactions. This includes comprehensive coverage of positive and negative resist formulations and processing, photoacid generation, silylation, single and multilayer resist systems, photomasks, dry and wet etching, photolithography, electron-beam, ion-beam and x-ray lithography technologies and process control, optical tools, exposure systems, radiation sources and steppers. Journal articles, conference proceedings and patents related to microlithography and resist technology are analyzed and indexed by scientific information analysts with strong technical background in these areas. The full CAS database, which is updated weekly with new information, is now available at your desktop, via a convenient, user-friendly tool called 'SciFinder.' Author, subject and chemical substance searching is simplified by SciFinder's smart search features. Chemical substances can be searched by chemical structure, chemical name, CAS registry number or molecular formula. Drawing chemical structures in SciFinder is easy and does not require compliance with CA conventions. Built-in intelligence of SciFinder enables users to retrieve substances with multiple components, tautomeric forms and salts.

  8. The SciELO Open Access: A Gold Way from the South

    ERIC Educational Resources Information Center

    Packer, Abel L.

    2009-01-01

    Open access has long emphasized access to scholarly materials. However, open access can also mean access to the means of producing visible and recognized journals. This issue is particularly important in developing and emergent countries. The SciELO (Scientific Electronic Library On-line) project, first started in Brazil and, shortly afterward, in…

  9. SciSpark's SRDD : A Scientific Resilient Distributed Dataset for Multidimensional Data

    NASA Astrophysics Data System (ADS)

    Palamuttam, R. S.; Wilson, B. D.; Mogrovejo, R. M.; Whitehall, K. D.; Mattmann, C. A.; McGibbney, L. J.; Ramirez, P.

    2015-12-01

    Remote sensing data and climate model output are multi-dimensional arrays of massive sizes locked away in heterogeneous file formats (HDF5/4, NetCDF 3/4) and metadata models (HDF-EOS, CF) making it difficult to perform multi-stage, iterative science processing since each stage requires writing and reading data to and from disk. We have developed SciSpark, a robust Big Data framework, that extends ApacheTM Spark for scaling scientific computations. Apache Spark improves the map-reduce implementation in ApacheTM Hadoop for parallel computing on a cluster, by emphasizing in-memory computation, "spilling" to disk only as needed, and relying on lazy evaluation. Central to Spark is the Resilient Distributed Dataset (RDD), an in-memory distributed data structure that extends the functional paradigm provided by the Scala programming language. However, RDDs are ideal for tabular or unstructured data, and not for highly dimensional data. The SciSpark project introduces the Scientific Resilient Distributed Dataset (sRDD), a distributed-computing array structure which supports iterative scientific algorithms for multidimensional data. SciSpark processes data stored in NetCDF and HDF files by partitioning them across time or space and distributing the partitions among a cluster of compute nodes. We show usability and extensibility of SciSpark by implementing distributed algorithms for geospatial operations on large collections of multi-dimensional grids. In particular we address the problem of scaling an automated method for finding Mesoscale Convective Complexes. SciSpark provides a tensor interface to support the pluggability of different matrix libraries. We evaluate performance of the various matrix libraries in distributed pipelines, such as Nd4jTM and BreezeTM. We detail the architecture and design of SciSpark, our efforts to integrate climate science algorithms, parallel ingest and partitioning (sharding) of A-Train satellite observations from model grids. These

  10. SCY-078 Is Fungicidal against Candida Species in Time-Kill Studies

    PubMed Central

    Scorneaux, Bernard; Angulo, David; Borroto-Esoda, Katyna; Ghannoum, Mahmoud; Peel, Michael

    2017-01-01

    ABSTRACT SCY-078 is an orally bioavailable ß-1,3-glucan synthesis inhibitor (GSI) and the first-in-class of structurally novel triterpene antifungals in clinical development for treating candidemia and invasive candidiasis. In vitro susceptibilities by broth microdilution, antifungal carryover, and time-kill dynamics were determined for three reference (ATCC) strains (Candida albicans 90028, Candida parapsilosis 90018, and Candida tropicalis 750), a quality-control (QC) strain (Candida krusei 6258), and four other strains (C. albicans MYA-2732, 64124, and 76485 and Candida glabrata 90030). Caspofungin (CASP), fluconazole (FLC), and voriconazole (VRC) were comparators. For time-kill experiments, SCY-078 and CASP were evaluated at 0.25, 1, 2, 4, 8, and 16 times the MIC80, and FLU and VRC were evaluated at 4× MIC80. The time to reach 50%, 90%, and 99.9% reduction in the number of CFUs from the starting inoculum was determined. Net change in the number of CFU per milliliter was used to determine 50% and 90% effective concentrations and maximum effect (EC50, EC90, and Emax, respectively). The SCY-078 MIC range was between 0.0625 and 1 μg/ml and generally similar to that of CASP. Antifungal carryover was not observed for SCY-078. SCY-078 was fungicidal against seven isolates at ≥4× MIC (kill of ≥3 log10) and achieved a 1.7-log10 reduction in CFU count/milliliter against C. albicans 90028. CASP behaved similarly against each isolate and achieved a 1.5-log10 reduction in the number of CFU/milliliter against C. albicans 90028. Reductions of 50% in CFU count/milliliter were achieved rapidly (1 to 2.8 h); fungicidal endpoints were reached at 12.1 to 21.8 h at ≥4× MIC. EC90 was reached at ∼5× MIC at each time point to 24 h. The EC50 and EC90 values were generally similar (8 to 24 h). Time-kill behavior of CASP was similar to that of SCY-078. FLC and VRC were fungistatic. Overall, SCY-078 has primarily fungicidal activity against Candida spp. and behaved

  11. SCY-078 Is Fungicidal against Candida Species in Time-Kill Studies.

    PubMed

    Scorneaux, Bernard; Angulo, David; Borroto-Esoda, Katyna; Ghannoum, Mahmoud; Peel, Michael; Wring, Stephen

    2017-03-01

    SCY-078 is an orally bioavailable ß-1,3-glucan synthesis inhibitor (GSI) and the first-in-class of structurally novel triterpene antifungals in clinical development for treating candidemia and invasive candidiasis. In vitro susceptibilities by broth microdilution, antifungal carryover, and time-kill dynamics were determined for three reference (ATCC) strains (Candida albicans 90028, Candida parapsilosis 90018, and Candida tropicalis 750), a quality-control (QC) strain (Candida krusei 6258), and four other strains (C. albicans MYA-2732, 64124, and 76485 and Candida glabrata 90030). Caspofungin (CASP), fluconazole (FLC), and voriconazole (VRC) were comparators. For time-kill experiments, SCY-078 and CASP were evaluated at 0.25, 1, 2, 4, 8, and 16 times the MIC80, and FLU and VRC were evaluated at 4× MIC80 The time to reach 50%, 90%, and 99.9% reduction in the number of CFUs from the starting inoculum was determined. Net change in the number of CFU per milliliter was used to determine 50% and 90% effective concentrations and maximum effect (EC50, EC90, and Emax, respectively). The SCY-078 MIC range was between 0.0625 and 1 μg/ml and generally similar to that of CASP. Antifungal carryover was not observed for SCY-078. SCY-078 was fungicidal against seven isolates at ≥4× MIC (kill of ≥3 log10) and achieved a 1.7-log10 reduction in CFU count/milliliter against C. albicans 90028. CASP behaved similarly against each isolate and achieved a 1.5-log10 reduction in the number of CFU/milliliter against C. albicans 90028. Reductions of 50% in CFU count/milliliter were achieved rapidly (1 to 2.8 h); fungicidal endpoints were reached at 12.1 to 21.8 h at ≥4× MIC. EC90 was reached at ∼5× MIC at each time point to 24 h. The EC50 and EC90 values were generally similar (8 to 24 h). Time-kill behavior of CASP was similar to that of SCY-078. FLC and VRC were fungistatic. Overall, SCY-078 has primarily fungicidal activity against Candida spp. and behaved comparably to CASP.

  12. Understanding Quality of Life in Adults with Spinal Cord Injury Via SCI-Related Needs and Secondary Complications

    PubMed Central

    Noreau, Luc; Leblond, Jean; Dumont, Frédéric S.

    2014-01-01

    Background: Understanding the factors that can predict greater quality of life (QoL) is important for adults with spinal cord injury (SCI), given that they report lower levels of QoL than the general population. Objectives: To build a conceptual model linking SCI-related needs, secondary complications, and QoL in adults with SCI. Prior to testing the conceptual model, we aimed to develop and evaluate the factor structure for both SCI-related needs and secondary complications. Methods: Individuals with a traumatic SCI (N = 1,137) responded to an online survey measuring 13 SCI-related needs, 13 secondary complications, and the Life Satisfaction Questionnaire to assess QoL. The SCI-related needs and secondary complications were conceptualized into factors, tested with a confirmatory factor analysis, and subsequently evaluated in a structural equation model to predict QoL. Results: The confirmatory factor analysis supported a 2-factor model for SCI related needs, χ2(61, N = 1,137) = 250.40, P <.001, comparative fit index (CFI) = .93, root mean square error of approximation (RMSEA) = .05, standardized root mean square residual (SRMR) = .04, and for 11 of the 13 secondary complications, χ2(44, N = 1,137) = 305.67, P < .001, CFI = .91, RMSEA = .060, SRMR = .033. The final 2 secondary complications were kept as observed constructs. In the structural model, both vital and personal development unmet SCI-related needs (β = -.22 and -.20, P < .05, respectively) and the neuro-physiological systems factor (β = -.45, P < .05) were negatively related with QoL. Conclusions: Identifying unmet SCI-related needs of individuals with SCI and preventing or managing secondary complications are essential to their QoL. PMID:25477745

  13. Science Classroom Inquiry (SCI) Simulations: A Novel Method to Scaffold Science Learning

    PubMed Central

    Peffer, Melanie E.; Beckler, Matthew L.; Schunn, Christian; Renken, Maggie; Revak, Amanda

    2015-01-01

    Science education is progressively more focused on employing inquiry-based learning methods in the classroom and increasing scientific literacy among students. However, due to time and resource constraints, many classroom science activities and laboratory experiments focus on simple inquiry, with a step-by-step approach to reach predetermined outcomes. The science classroom inquiry (SCI) simulations were designed to give students real life, authentic science experiences within the confines of a typical classroom. The SCI simulations allow students to engage with a science problem in a meaningful, inquiry-based manner. Three discrete SCI simulations were created as website applications for use with middle school and high school students. For each simulation, students were tasked with solving a scientific problem through investigation and hypothesis testing. After completion of the simulation, 67% of students reported a change in how they perceived authentic science practices, specifically related to the complex and dynamic nature of scientific research and how scientists approach problems. Moreover, 80% of the students who did not report a change in how they viewed the practice of science indicated that the simulation confirmed or strengthened their prior understanding. Additionally, we found a statistically significant positive correlation between students’ self-reported changes in understanding of authentic science practices and the degree to which each simulation benefitted learning. Since SCI simulations were effective in promoting both student learning and student understanding of authentic science practices with both middle and high school students, we propose that SCI simulations are a valuable and versatile technology that can be used to educate and inspire a wide range of science students on the real-world complexities inherent in scientific study. PMID:25786245

  14. Science classroom inquiry (SCI) simulations: a novel method to scaffold science learning.

    PubMed

    Peffer, Melanie E; Beckler, Matthew L; Schunn, Christian; Renken, Maggie; Revak, Amanda

    2015-01-01

    Science education is progressively more focused on employing inquiry-based learning methods in the classroom and increasing scientific literacy among students. However, due to time and resource constraints, many classroom science activities and laboratory experiments focus on simple inquiry, with a step-by-step approach to reach predetermined outcomes. The science classroom inquiry (SCI) simulations were designed to give students real life, authentic science experiences within the confines of a typical classroom. The SCI simulations allow students to engage with a science problem in a meaningful, inquiry-based manner. Three discrete SCI simulations were created as website applications for use with middle school and high school students. For each simulation, students were tasked with solving a scientific problem through investigation and hypothesis testing. After completion of the simulation, 67% of students reported a change in how they perceived authentic science practices, specifically related to the complex and dynamic nature of scientific research and how scientists approach problems. Moreover, 80% of the students who did not report a change in how they viewed the practice of science indicated that the simulation confirmed or strengthened their prior understanding. Additionally, we found a statistically significant positive correlation between students' self-reported changes in understanding of authentic science practices and the degree to which each simulation benefitted learning. Since SCI simulations were effective in promoting both student learning and student understanding of authentic science practices with both middle and high school students, we propose that SCI simulations are a valuable and versatile technology that can be used to educate and inspire a wide range of science students on the real-world complexities inherent in scientific study.

  15. Atoms and Molecules. Study Guide. Unit 2. ZIM-SCI, Zimbabwe Secondary School Science Project. Year 3.

    ERIC Educational Resources Information Center

    Mandizha, George

    The Zimbabwe Secondary School Science Project (ZIM-SCI) developed student study guides, corresponding teaching guides, and science kits for a low-cost science course which could be taught during the third year of secondary school without the aid of qualified teachers and conventional laboratories. This ZIM-SCI study guide is a four-part unit…

  16. Using Electricity. Study Guide. Unit I2. ZIM-SCI, Zimbabwe Secondary School Science Project. Year 2.

    ERIC Educational Resources Information Center

    Chidume, Kwashira

    The Zimbabwe Secondary School Science Project (ZIM-SCI) developed student study guides, corresponding teaching guides, and science kits for a low-cost science course which could be taught during the first 2 years of secondary school without the aid of qualified teachers and conventional laboratories. This ZIM-SCI study guide presents activities…

  17. Understanding Electricity. Study Guide. Unit I1. ZIM-SCI, Zimbabwe Secondary School Science Project. Year 2.

    ERIC Educational Resources Information Center

    Chidume, Kwashira

    The Zimbabwe Secondary School Science Project (ZIM-SCI) developed student study guides, corresponding teaching guides, and science kits for a low-cost science course which could be taught during the first 2 years of secondary school without the aid of qualified teachers and conventional laboratories. This ZIM-SCI study guide presents activities…

  18. Ranking Business and Economics Journals in South America Using the Scientific Electronic Library Online (SciELO)

    ERIC Educational Resources Information Center

    Alexander, Jennifer K.; Pradenas, Lorena; Parada, Victor; Scherer, Robert F.

    2012-01-01

    Access to published research for knowledge creation and education in the administrative science disciplines in South America has been enhanced since the introduction of the Scientific Electronic Library Online (SciELO). Although SciELO has been available as an online journal indexing and publication service since 1998, there have been no…

  19. 32 CFR 147.32 - Temporary eligibility for access at the top secret and SCI levels and temporary eligibility for...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 1 2011-07-01 2011-07-01 false Temporary eligibility for access at the top secret and SCI levels and temporary eligibility for âQâ access authorization: For someone who is not the... Guidelines for Temporary Access § 147.32 Temporary eligibility for access at the top secret and SCI...

  20. 32 CFR 147.32 - Temporary eligibility for access at the top secret and SCI levels and temporary eligibility for...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false Temporary eligibility for access at the top secret and SCI levels and temporary eligibility for âQâ access authorization: For someone who is not the... Guidelines for Temporary Access § 147.32 Temporary eligibility for access at the top secret and SCI...

  1. What Do You Know about Water? Study Guide. Unit D. ZIM-SCI, Zimbabwe Secondary School Science Project.

    ERIC Educational Resources Information Center

    Dube, Peter

    The Zimbabwe Secondary School Science Project (ZIM-SCI) developed student study guides, corresponding teaching guides, and science kits for a low-cost science course which could be taught during the first 2 years of secondary school without the aid of qualified teachers and conventional laboratories. This ZIM-SCI study guide is a three-part unit…

  2. Life, Beginning and Growing. Study Guide. Unit E1. ZIM-SCI, Zimbabwe Secondary School Science Project.

    ERIC Educational Resources Information Center

    Hosking, Bunty

    The Zimbabwe Secondary School Science Project (ZIM-SCI) developed student study guides, corresponding teaching guides, and science kits for a low-cost science course which could be taught during the first 2 years of secondary school without the aid of qualified teachers and conventional laboratories. This ZIM-SCI study guide is a three-part unit…

  3. 32 CFR 147.32 - Temporary eligibility for access at the top secret and SCI levels and temporary eligibility for...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 1 2014-07-01 2014-07-01 false Temporary eligibility for access at the top secret and SCI levels and temporary eligibility for âQâ access authorization: For someone who is not the... Guidelines for Temporary Access § 147.32 Temporary eligibility for access at the top secret and SCI...

  4. Our Planet Earth. Teacher's Guide. Unit F1. ZIM-SCI, Zimbabwe Secondary School Science Project. Year 2.

    ERIC Educational Resources Information Center

    Stocklmayer, Sue

    The Zimbabwe Secondary School Science Project (ZIM-SCI) developed student study guides, corresponding teaching guides, and science kits for a low-cost science course which could be taught during the first 2 years of secondary school without the aid of qualified teachers and conventional laboratories. This ZIM-SCI study guide presents activities,…

  5. Reproducing by Flowers and Seeds. Study Guide. Unit E2. ZIM-SCI, Zimbabwe Secondary School Science Project.

    ERIC Educational Resources Information Center

    Zesaguli, Josie

    The Zimbabwe Secondary School Science Project (ZIM-SCI) developed student study guides, corresponding teaching guides, and science kits for a low-cost science course which could be taught during the first 2 years of secondary school without the aid of qualified teachers and environmental laboratories. This ZIM-SCI study guide consists of…

  6. Sense from Senses. Study Guide. Unit J. ZIM-SCI, Zimbabwe Secondary School Science Project. Year 2.

    ERIC Educational Resources Information Center

    Simango, Sam

    The Zimbabwe Secondary School Science Project (ZIM-SCI) developed student study guides, corresponding teaching guides, and science kits for a low-cost science course which could be taught during the first 2 years of secondary school without the aid of qualified teachers and conventional laboratories. This ZIM-SCI study guide presents activities…

  7. Forces in Living Things. Study Guide. Unit H2. ZIM-SCI, Zimbabwe Secondary School Science Project. Year 2.

    ERIC Educational Resources Information Center

    Hosking, Bunty; Zesaguli, Josie

    The Zimbabwe Secondary School Science Project (ZIM-SCI) developed student study guides, corresponding teaching guides, and science kits for a low-cost science course which could be taught during the first 2 years of secondary school without the aid of qualified teachers and conventional laboratories. This ZIM-SCI study guide presents activities…

  8. Learning to be a Scientist. Study Guide. Unit A1. ZIM-SCI, Zimbabwe Secondary School Science Project.

    ERIC Educational Resources Information Center

    Stocklmayer, Sue

    The Zimbabwe Secondary School Science Project (ZIM-SCI) developed student study guides, corresponding teaching guides, and science kits for a low-cost science course which could be taught during the first 2 years of secondary school without the aid of qualified teachers and conventional laboratories. This ZIM-SCI study guide introduces students to…

  9. Living Things and Their Food. Study Guide. Unit G2. ZIM-SCI, Zimbabwe Secondary School Science Project. Year 2.

    ERIC Educational Resources Information Center

    Hosking, Bunty

    The Zimbabwe Secondary School Science Project (ZIM-SCI) developed student study guides, corresponding teaching guides, and science kits for a low-cost science course which could be taught during the first 2 years of secondary school without the aid of qualified teachers and conventional laboratories. This ZIM-SCI study guide presents activities…

  10. Energy for Living. Study Guide. Unit G1. ZIM-SCI, Zimbabwe Secondary School Science Project. Year 2.

    ERIC Educational Resources Information Center

    Hosking, Bunty

    The Zimbabe Secondary School Science Project (ZIM-SCI) developed student study guides, corresponding teaching guides, and science kits for a low-cost science course which could be taught during the first 2 years of secondary school without the aid of qualified teachers and conventional laboratories. This ZIM-SCI study guide includes activities and…

  11. Forces in Action. Study Guide. Unit H1. ZIM-SCI, Zimbabwe Secondary School Science Project. Year 2.

    ERIC Educational Resources Information Center

    Dube, Peter

    The Zimbabwe Secondary School Science Project (ZIM-SCI) developed student study guides, corresponding teaching guides, and science kits for a low-cost science course which could be taught during the first 2 years of secondary school without the aid of qualified teachers and conventional laboratories. This ZIM-SCI study guide presents activities…

  12. Interaction of polyethylene glycol (PEG) with the membrane-binding domains following spinal cord injury (SCI): introduction of a mechanism for SCI repair.

    PubMed

    Rad, Iman; Khodayari, Kaveh; Hadi Alijanvand, Saeid; Mobasheri, Hamid

    2015-01-01

    Lipid-binding domains regulate positioning of the membrane proteins via specific interactions with phospholipid's head groups. Spinal cord injury (SCI) diminishes the integrity of neural fiber membranes at nanoscopic level. In cases that the ruptured zone size is beyond the natural resealing ability, there is a need for reinforcing factors such as polymers (e.g. Polyethylene glycol) to patch the dismantled axoplasm. Certain conserved sequential and structural patterns of interacting residues specifically bind to PEGs. It is also found that PEG600, PEG400 and PEG200 share the strongest interaction with the lipid-binding domains even more successful than phospholipid head groups. The alpha helix structure composed of hydrophobic, neutral and acidic residues prepares an opportunity for PEG400 to play an amphipathic role in the interaction with injured membrane. This in-silico study introduces a mechanism for PEG restorative ability at the molecular level. It is believed that PEG400 interrelates the injured membrane to their underneath axoplasm while retaining the integrity of ruptured membrane via interaction with ENTH domains of membrane proteins. This privilege of PEG400 in treating injured membrane must be considered in designing of polymeric biomaterials that are introduced for SCI repair.

  13. GENESIS SciFlo: Enabling Multi-Instrument Atmospheric Science Using Grid Workflows

    NASA Astrophysics Data System (ADS)

    Wilson, B. D.; Tang, B.; Manipon, G.; Yunck, T.; Fetzer, E.; Braverman, A.; Dobinson, E.

    2004-12-01

    The General Earth Science Investigation Suite (GENESIS) project is a NASA-sponsored partnership between the Jet Propulsion Laboratory, academia, and NASA data centers to develop a new suite of web services tools to facilitate multi-sensor investigations in Earth System Science. The goal of GENESIS is to enable large-scale, multi-instrument atmospheric science using combined datasets from the AIRS, MODIS, MISR, and GPS sensors. Investigations will include cross-comparison of spaceborne climate sensors, cloud spectral analysis, study of upper troposphere-strato-sphere water transport, study of the aerosol indirect cloud effect, and global climate model validation. The challenges are to bring together very large datasets, reformat and understand the individual instrument retrievals, co-register or re-grid the retrieved physical parameters, perform computationally-intensive data fusion and data mining operations, and accumulate complex statistics over months to years of data. To meet these challenges, we are developing a Grid computing and dataflow framework, named SciFlo, in which we are deploying a set of versatile and reusable operators for data access, subsetting, registration, mining, fusion, compression, and advanced statistical analysis. SciFlo is a system for Scientific Knowledge Creation on the Grid using a Semantically-Enabled Dataflow Execution Environment. SciFlo leverages Simple Object Access Protocol (SOAP) Web Services and the Grid Computing standards (Globus Alliance toolkits), and enables scientists to do multi-instrument Earth Science by assembling reusable web services and executable operators into a distributed computing flow (operator tree). The SciFlo client & server engines optimize the execution of such distributed data flows and allow the user to transparently find and use datasets and operators without worrying about the actual location of the Grid resources. The scientist injects a distributed computation into the Grid by simply filling out

  14. GeoSciGraph: An Ontological Framework for EarthCube Semantic Infrastructure

    NASA Astrophysics Data System (ADS)

    Gupta, A.; Schachne, A.; Condit, C.; Valentine, D.; Richard, S.; Zaslavsky, I.

    2015-12-01

    The CINERGI (Community Inventory of EarthCube Resources for Geosciences Interoperability) project compiles an inventory of a wide variety of earth science resources including documents, catalogs, vocabularies, data models, data services, process models, information repositories, domain-specific ontologies etc. developed by research groups and data practitioners. We have developed a multidisciplinary semantic framework called GeoSciGraph semantic ingration of earth science resources. An integrated ontology is constructed with Basic Formal Ontology (BFO) as its upper ontology and currently ingests multiple component ontologies including the SWEET ontology, GeoSciML's lithology ontology, Tematres controlled vocabulary server, GeoNames, GCMD vocabularies on equipment, platforms and institutions, software ontology, CUAHSI hydrology vocabulary, the environmental ontology (ENVO) and several more. These ontologies are connected through bridging axioms; GeoSciGraph identifies lexically close terms and creates equivalence class or subclass relationships between them after human verification. GeoSciGraph allows a community to create community-specific customizations of the integrated ontology. GeoSciGraph uses the Neo4J,a graph database that can hold several billion concepts and relationships. GeoSciGraph provides a number of REST services that can be called by other software modules like the CINERGI information augmentation pipeline. 1) Vocabulary services are used to find exact and approximate terms, term categories (community-provided clusters of terms e.g., measurement-related terms or environmental material related terms), synonyms, term definitions and annotations. 2) Lexical services are used for text parsing to find entities, which can then be included into the ontology by a domain expert. 3) Graph services provide the ability to perform traversal centric operations e.g., finding paths and neighborhoods which can be used to perform ontological operations like

  15. Paul Langevin's 1908 paper ``On the Theory of Brownian Motion'' [``Sur la théorie du mouvement brownien,'' C. R. Acad. Sci. (Paris) 146, 530-533 (1908)

    NASA Astrophysics Data System (ADS)

    Lemons, Don S.; Gythiel, Anthony

    1997-11-01

    We present a translation of Paul Langevin's landmark paper. In it Langevin successfully applied Newtonian dynamics to a Brownian particle and so invented an analytical approach to random processes which has remained useful to this day.

  16. Inroads into base excision repair II. The discovery of DNA glycosylases. "An N-glycosidase from Escherichia coli that releases free uracil from DNA containing deaminated cytosine residues," Proc. Nat. Acad. Sci. USA, 1974.

    PubMed

    Friedberg, Errol C; Lindahl, Tomas

    2004-11-02

    The discovery of a DNA glycosylase that specifically removes uracil from DNA, opened the door for uncovering a large class of such enzymes that are fundamental to the process of base excision repair of DNA.

  17. Proteolysis of the class II-associated invariant chain generates a peptide binding site in intracellular HLA-DR molecules. Proc. Natl. Acad. Sci. USA. 1991. 88: 3150-3154.

    PubMed

    Roche, Paul A; Cresswell, Peter

    2011-08-01

    HLA-DR molecules are heterodimeric transmembrane glycoproteins that associate intracellularly with a polypeptide known as the invariant (I) chain. Shortly before expression of the HLA-DR αβ dimer on the cell surface, however the I chain is removed from the intracellular αβI complex by a mechanism thought to involve proteolysis . In this report, we show that treatment of purified αβI with the cysteine proteinase cathepsin B results in the specific proteolysis of the HLA-DR-associated I chain in vitro. As a consequence of this, the I chain is removed and free αβ dimers are released from αβI. Although αβI fails to bind an immunogenic peptide, the released αβ dimers acquire the ability to bind the peptide after proteolysis of the I chain. These results suggest that the I chain inhibits immunogenic peptide binding to αβI early during intracellular transport and demonstrate that proteolysis is likely to be the in vivo mechanism of I chain removal.

  18. SCiP at 35: an idiosyncratic history of the society for computers in psychology.

    PubMed

    Wolfe, Christopher R

    2006-05-01

    SCiP history may be divided into three eras: the Paleozoic (1971-1982), the Mesozoic (1982-1994), and the Cenozoic (1994-present). Following a list of Secretary-Treasurers, a list of all SCiP Presidents is provided in Table 1. Next I present personal highlights, including the first symposium on psychology and the World-Wide Web; David Rumelhart's mathematical explanation of connectionism; and Stevan Hamad's discussion of "freeing" the journal literature. I observe that a small conference is becoming more intimate and that much of our mission involves figuring out how to conduct high-quality scientific research with consumer-grade electronics. I argue that we are an increasingly international organization, that graduate students are welcome, and that we should become more inclusive in the areas of gender and ethnicity and should make membership more meaningful I conclude by looking ahead and attempting to predict the future.

  19. Simulations with SCI as a data carrier in data acquisition systems

    SciTech Connect

    Kristiansen, E.H. Univ. of Oslo . Dept. of Physics); Bothner, J.W.; Hulaas, T.I.; Skaali, T.B. ); Rongved, E. )

    1994-02-01

    Detailed simulations of processor networks based on the Scalable Coherent Interface (SCI) show that SCI is suitable as data carrier in data acquisition systems where the total bandwidth need is in the multi GBytes/s range and a low latency is required. The objective of these simulations was to find topologies with low latency and high bandwidth, but also with the cost of implementation in mind. A ring-to-ring bridge has been used as the building element for the networks. The simulations have been performed on regular k-ary n-cubes type topologies from a few tens of nodes and up to about 500 nodes under different load conditions. Among the parameters which has been manipulated in the simulations are the number of nodes, topology structure, number of outstanding requests and load in the system.

  20. Assembling Large, Multi-Sensor Climate Datasets Using the SciFlo Grid Workflow System

    NASA Astrophysics Data System (ADS)

    Wilson, B. D.; Manipon, G.; Xing, Z.; Fetzer, E.

    2008-12-01

    NASA's Earth Observing System (EOS) is the world's most ambitious facility for studying global climate change. The mandate now is to combine measurements from the instruments on the A-Train platforms (AIRS, AMSR-E, MODIS, MISR, MLS, and CloudSat) and other Earth probes to enable large-scale studies of climate change over periods of years to decades. However, moving from predominantly single-instrument studies to a multi-sensor, measurement-based model for long-duration analysis of important climate variables presents serious challenges for large-scale data mining and data fusion. For example, one might want to compare temperature and water vapor retrievals from one instrument (AIRS) to another instrument (MODIS), and to a model (ECMWF), stratify the comparisons using a classification of the cloud scenes from CloudSat, and repeat the entire analysis over years of AIRS data. To perform such an analysis, one must discover & access multiple datasets from remote sites, find the space/time matchups between instruments swaths and model grids, understand the quality flags and uncertainties for retrieved physical variables, and assemble merged datasets for further scientific and statistical analysis. To meet these large-scale challenges, we are utilizing a Grid computing and dataflow framework, named SciFlo, in which we are deploying a set of versatile and reusable operators for data query, access, subsetting, co-registration, mining, fusion, and advanced statistical analysis. SciFlo is a semantically-enabled ("smart") Grid Workflow system that ties together a peer-to-peer network of computers into an efficient engine for distributed computation. The SciFlo workflow engine enables scientists to do multi-instrument Earth Science by assembling remotely-invokable Web Services (SOAP or http GET URLs), native executables, command-line scripts, and Python codes into a distributed computing flow. A scientist visually authors the graph of operation in the VizFlow GUI, or uses a

  1. Assembling Large, Multi-Sensor Climate Datasets Using the SciFlo Grid Workflow System

    NASA Astrophysics Data System (ADS)

    Wilson, B.; Manipon, G.; Xing, Z.; Fetzer, E.

    2009-04-01

    NASA's Earth Observing System (EOS) is an ambitious facility for studying global climate change. The mandate now is to combine measurements from the instruments on the "A-Train" platforms (AIRS, AMSR-E, MODIS, MISR, MLS, and CloudSat) and other Earth probes to enable large-scale studies of climate change over periods of years to decades. However, moving from predominantly single-instrument studies to a multi-sensor, measurement-based model for long-duration analysis of important climate variables presents serious challenges for large-scale data mining and data fusion. For example, one might want to compare temperature and water vapor retrievals from one instrument (AIRS) to another instrument (MODIS), and to a model (ECMWF), stratify the comparisons using a classification of the "cloud scenes" from CloudSat, and repeat the entire analysis over years of AIRS data. To perform such an analysis, one must discover & access multiple datasets from remote sites, find the space/time "matchups" between instruments swaths and model grids, understand the quality flags and uncertainties for retrieved physical variables, assemble merged datasets, and compute fused products for further scientific and statistical analysis. To meet these large-scale challenges, we are utilizing a Grid computing and dataflow framework, named SciFlo, in which we are deploying a set of versatile and reusable operators for data query, access, subsetting, co-registration, mining, fusion, and advanced statistical analysis. SciFlo is a semantically-enabled ("smart") Grid Workflow system that ties together a peer-to-peer network of computers into an efficient engine for distributed computation. The SciFlo workflow engine enables scientists to do multi-instrument Earth Science by assembling remotely-invokable Web Services (SOAP or http GET URLs), native executables, command-line scripts, and Python codes into a distributed computing flow. A scientist visually authors the graph of operation in the Viz

  2. Psychosocial and Behavioral Factors Associated with Bowel and Bladder Management after SCI

    DTIC Science & Technology

    2013-10-01

    family in the Jersey Shore and we stopped in Hershey, Pennsylvania. We stopped there for the night and we were thinking we’d go tour the chocolate ... mood , going out into the community and taking care of bowel and bladder dysfunction. The study is asking persons with SCI (civilians and veterans) and...You will also complete a series of questionnaires about your mood , the quality of care you get, and you bowel and bladder program and any specific

  3. FES-Rowing versus Zoledronic Acid to Improve Bone Health in SCI

    DTIC Science & Technology

    2012-10-01

    loss or to induce new bone formation following SCI, although the risk is high in this population of osteoporosis -related bone fracture. This study...aims to learn if the severe osteoporosis in lower extremities caused by spinal cord injuries can be slowed or reversed with a combination of an... exercise that simulates weight-bearing and a bisphosphonate medication. 70 Individuals with T3-12 spinal cord injuries will be enrolled in a 12-month

  4. T-1025 IU SciBath-768 detector tests in MI-12

    SciTech Connect

    Tayloe, Rex; Cooper, R.; Garrison, L.; Thornton, T.; Rebenitsch, L.; DeJongh, Fritz; Loer, Benjamin; Ramberg, Erik; Yoo, Jonghee; /Fermilab

    2012-02-11

    This is a memorandum of understanding between the Fermi National Accelerator Laboratory (Fermilab) and the experimenters of Department of Physics and Center for Exploration of Energy and Matter, Indiana University, who have committed to participate in detector tests to be carried out during the 2012 Fermilab Neutrino program. The memorandum is intended solely for the purpose of recording expectations for budget estimates and work allocations for Fermilab, the funding agencies and the participating institutions. it reflects an arrangement that currently is satisfactory to the parties; however, it is recognized and anticipated that changing circumstances of the evolving research program will necessitate revisions. The parties agree to modify this memorandum to reflect such required adjustments. Actual contractual obligations will be set forth in separate documents. The experimenters propsoe to test their prototype 'SciBat-768' detector in the MI-12 building for 3 months (February-April) in Spring 2012. The major goal of this effort is to measure or limit the flux of beam-induced neutrons in a far-off-axis (> 45{sup o}) location of the Booster Neutrino Beamline (BNB). This flux is of interest for a proposed coherent neutral-current neutrino-argon elastic scattering experiment. A second goal is to collect more test data for the SciBath-768 to enable better understanding and calibration of the device. The SciBath-768 detector successfully ran for 3 months in the MINOS Underground Area in Fall 2011 as testbeam experiment T-1014 and is currently running above ground in the MINOS service building. For the run proposed here, the experiments are requesting: space in MI-12 in which to run the SciBath detector during February-April 2012 while the BNB is operating; technical support to help with moving the equipment on site; access to power, internet, and accelerator signals; and a small office space from which to run and monitor the experiment.

  5. SciDAC Visualization and Analytics Center for EnablingTechnology

    SciTech Connect

    Bethel, E. Wes; Johnson, Chris; Joy, Ken; Ahern, Sean; Pascucci,Valerio; Childs, Hank; Cohen, Jonathan; Duchaineau, Mark; Hamann, Bernd; Hansen, Charles; Laney, Dan; Lindstrom, Peter; Meredith, Jeremy; Ostrouchov, George; Parker, Steven; Silva, Claudio; Sanderson, Allen; Tricoche, Xavier

    2006-11-28

    The SciDAC2 Visualization and Analytics Center for EnablingTechnologies (VACET) began operation on 10/1/2006. This document, dated11/27/2006, is the first version of the VACET project management plan. Itwas requested by and delivered to ASCR/DOE. It outlines the Center'saccomplishments in the first six weeks of operation along with broadobjectives for the upcoming future (12-24 months).

  6. Developing a Meaningful Life: Social Reintegration of Service-Members and Veterans with SCI

    DTIC Science & Technology

    2014-10-01

    military veteran who suffered a service-related traumatic SCI. Methods: An in-depth anthropological interview was used with Jake, a 28-year old marine...spinal cord injury. 9 Participants Seth Messinger, Principal Investigator Associate Professor of Anthropology Seth Messinger is responsible...Networks for Veterans with Spinal Cord Injury in Obtaining Employment. Annals of Anthropological Practice. 37,2:40-56 Fritz, H., Lysack, C

  7. Improvement in student science proficiency through InSciEd out.

    PubMed

    Pierret, Chris; Sonju, James D; Leicester, Jean E; Hoody, Maggie; LaBounty, Thomas J; Frimannsdottir, Katrin R; Ekker, Stephen C

    2012-12-01

    Integrated Science Education Outreach (InSciEd Out) is a collaboration formed between Mayo Clinic, Winona State University, and Rochester Public Schools (MN) with the shared vision of achieving excellence in science education. InSciEd Out employs an equitable partnership model between scientists, teachers, education researchers, and the community. Teams of teachers from all disciplines within a single school experience cutting-edge science using the zebrafish model system, as well as current pedagogical methods, during a summer internship at the Mayo Clinic. Within the internship, the teachers produce new curriculum that directly addresses opportunities for science education improvement at their own school. Zebrafish are introduced within the new curriculum to support a living model of the practice of science. Following partnership with the InSciEd Out program and 2 years of implementation in the classroom, teacher-interns from a K-8 public school reported access to local scientific technology and expertise they had not previously recognized. Teachers also reported improved integration of other disciplines into the scientific curriculum and a flow of concepts vertically from K through 8. Students more than doubled selection of an Honors science track in high school to nearly 90%. 98% of students who took the Minnesota Comprehensive Assessments in their 5(th) and 8(th) grade year (a span that includes 2 years of InSciEd Out) showed medium or high growth in science proficiency. These metrics indicate that cooperation between educators and scientists can result in positive change in student science proficiency and demonstrate that a higher expectation in science education can be achieved in US public schools.

  8. Improvement in Student Science Proficiency Through InSciEd Out

    PubMed Central

    Sonju, James D.; Leicester, Jean E.; Hoody, Maggie; LaBounty, Thomas J.; Frimannsdottir, Katrin R.; Ekker, Stephen C.

    2012-01-01

    Abstract Integrated Science Education Outreach (InSciEd Out) is a collaboration formed between Mayo Clinic, Winona State University, and Rochester Public Schools (MN) with the shared vision of achieving excellence in science education. InSciEd Out employs an equitable partnership model between scientists, teachers, education researchers, and the community. Teams of teachers from all disciplines within a single school experience cutting-edge science using the zebrafish model system, as well as current pedagogical methods, during a summer internship at the Mayo Clinic. Within the internship, the teachers produce new curriculum that directly addresses opportunities for science education improvement at their own school. Zebrafish are introduced within the new curriculum to support a living model of the practice of science. Following partnership with the InSciEd Out program and 2 years of implementation in the classroom, teacher-interns from a K–8 public school reported access to local scientific technology and expertise they had not previously recognized. Teachers also reported improved integration of other disciplines into the scientific curriculum and a flow of concepts vertically from K through 8. Students more than doubled selection of an Honors science track in high school to nearly 90%. 98% of students who took the Minnesota Comprehensive Assessments in their 5th and 8th grade year (a span that includes 2 years of InSciEd Out) showed medium or high growth in science proficiency. These metrics indicate that cooperation between educators and scientists can result in positive change in student science proficiency and demonstrate that a higher expectation in science education can be achieved in US public schools. PMID:23244687

  9. The Small Carry-on Impactor (SCI) and the Hayabusa2 Impact Experiment

    NASA Astrophysics Data System (ADS)

    Saiki, T.; Imamura, H.; Arakawa, M.; Wada, K.; Takagi, Y.; Hayakawa, M.; Shirai, K.; Yano, H.; Okamoto, C.

    2016-10-01

    Hayabusa2 is a sample return mission of JAXA launched on 3 December 2014. Hayabusa2 is the successor of Hayabusa, which returned samples from the asteroid Itokawa to the Earth. Although the design of Hayabusa2 follows that of Hayabusa, the former is equipped with some new components. The small carry-on impactor (SCI) is one of those components. The SCI is a compact kinetic impactor designed to remove the asteroid surface regolith locally and create an artificial crater. One of the most important scientific objectives of Hayabusa2 is to investigate the chemical and physical properties of the internal materials and structures of the target body, asteroid Ryugu. Hayabusa2 will attempt to observe the resultant crater with some scientific instruments and to get samples from around the crater. High kinetic energy is required to create a meaningful crater, however, the impact system design needs to fit within strict constraints. Complicated functions, such as a guidance and control system, are not permitted. A special type of shaped charge is used for the acceleration of the impactor of the SCI in order to make system simpler. Using this explosion technique makes it possible to accelerate the impactor very quickly and to hit the asteroid without a guidance system. However, the impact operation will be complicated because the explosive is very powerful and it scatters high-speed debris at the detonation. This paper describes an overview of the SCI system, the results of the development testing and an outline of the impact experiment of the Hayabusa2 mission.

  10. Obesity/Overweight in Persons With Early and Chronic SCI: A Randomized, Multicenter, Controlled Lifestyle Intervention

    DTIC Science & Technology

    2014-10-01

    modeled after the landmark Diabetes Prevention Program (DPP) on obesity and component disease risks. The TLI consists of a 6-month clinical program...clinical trial (RCT) conducted at 2 SCI rehabilitation research centers and a Veterans Affairs Medical Centers. The study is modeled after the Diabetes ...Prevention Program (DPP), an NIH-sponsored 27-center RCT that reported a sustained 7% body weight reduction in pre- diabetic individuals accompanied by

  11. Pressure Relief Behaviors and Weight Shifting Activities to Prevent Pressure Ulcers in Persons with SCI

    DTIC Science & Technology

    2015-10-01

    PRINCIPAL INVESTIGATOR: Stephen Sprigle, PhD, PT CONTRACTING ORGANIZATION: Georgia Tech Research Corporation Atlanta GA 30332-0001 REPORT DATE...AND ADDRESS(ES) AND ADDRESS(ES) 8. PERFORMING ORGANIZATION REPORT NUMBER Georgia Tech Research Corporation 505 10th St NW Atlanta GA 30332-0001 9...activities in persons with SCI Submitted to and Approved by: - Georgia Tech , Shepherd Center, Kessler have each approved the protocol - HRPO

  12. SciDAC Center for Gyrokinetic Particle Simulation of Turbulent Transport in Burning Plasmas

    SciTech Connect

    Lin, Zhihong

    2013-12-18

    During the first year of the SciDAC gyrokinetic particle simulation (GPS) project, the GPS team (Zhihong Lin, Liu Chen, Yasutaro Nishimura, and Igor Holod) at the University of California, Irvine (UCI) studied the tokamak electron transport driven by electron temperature gradient (ETG) turbulence, and by trapped electron mode (TEM) turbulence and ion temperature gradient (ITG) turbulence with kinetic electron effects, extended our studies of ITG turbulence spreading to core-edge coupling. We have developed and optimized an elliptic solver using finite element method (FEM), which enables the implementation of advanced kinetic electron models (split-weight scheme and hybrid model) in the SciDAC GPS production code GTC. The GTC code has been ported and optimized on both scalar and vector parallel computer architectures, and is being transformed into objected-oriented style to facilitate collaborative code development. During this period, the UCI team members presented 11 invited talks at major national and international conferences, published 22 papers in peer-reviewed journals and 10 papers in conference proceedings. The UCI hosted the annual SciDAC Workshop on Plasma Turbulence sponsored by the GPS Center, 2005-2007. The workshop was attended by about fifties US and foreign researchers and financially sponsored several gradual students from MIT, Princeton University, Germany, Switzerland, and Finland. A new SciDAC postdoc, Igor Holod, has arrived at UCI to initiate global particle simulation of magnetohydrodynamics turbulence driven by energetic particle modes. The PI, Z. Lin, has been promoted to the Associate Professor with tenure at UCI.

  13. Supporting Research using Satellite Data: A Framework for Spatiotemporal Queries in SciDB

    NASA Astrophysics Data System (ADS)

    Ho, S. S.; Krcal, L.

    2015-12-01

    Natural phenomena such as haze, hurricane, and blizzard that evolve over time usually do not have well-defined boundaries. Their features may be captured by multiple satellites. To process and extract information from the large-scale satellite data, one needs a data-intensive architecture for distributed storage and computation resources. Such architecture allows end users such as scientists to effectively run their computation tasks with sharing computational resources and intermediate results, but without data replication. The satellite data is most conveniently represented using arrays, exploiting its multidimensional nature. For our investigation, we use the open-source distributed, array-based SciDB as a platform for our spatiotemporal framework. SciDB conforms with the data-intensive architecture, providing a highly effectively computational and data storage platform. Moreover, it provides standard extension points, i.e., user defined data types, operators and functions. Our current work focuses on more sophisticated indices including cartesian-coordinate indices, hierarchical triangular mesh and hybrid indices with data statistics and indexing. Furthermore, we introduce a spatiotemporal framework that allows us to generate and maintain indices according to given criteria and perform spatial and temporal operators and predicates. This framework overcomes weaknesses in SciDB where standard underlying array operations are less effective. We will demonstrate some examples (e.g., hurricane research using satellite data) of the functionalities in the proposed spatiotemporal framework.

  14. Comparing NetCDF and SciDB on managing and querying 5D hydrologic dataset

    NASA Astrophysics Data System (ADS)

    Liu, Haicheng; Xiao, Xiao

    2016-11-01

    Efficiently extracting information from high dimensional hydro-meteorological modelling datasets requires smart solutions. Traditional methods are mostly based on files, which can be edited and accessed handily. But they have problems of efficiency due to contiguous storage structure. Others propose databases as an alternative for advantages such as native functionalities for manipulating multidimensional (MD) arrays, smart caching strategy and scalability. In this research, NetCDF file based solutions and the multidimensional array database management system (DBMS) SciDB applying chunked storage structure are benchmarked to determine the best solution for storing and querying 5D large hydrologic modelling dataset. The effect of data storage configurations including chunk size, dimension order and compression on query performance is explored. Results indicate that dimension order to organize storage of 5D data has significant influence on query performance if chunk size is very large. But the effect becomes insignificant when chunk size is properly set. Compression of SciDB mostly has negative influence on query performance. Caching is an advantage but may be influenced by execution of different query processes. On the whole, NetCDF solution without compression is in general more efficient than the SciDB DBMS.

  15. [SciELO: A cooperative project for the dissemination of science].

    PubMed

    Bojo Canales, C; Fraga Medín, C; Hernández Villegas, S; Primo Peña, E

    2009-10-01

    The article describes the SciELO (Scientific Electronic Library Online) model for the electronic publication and dissemination of scientific journals, its origin and evolution, methodology, components, services and potential, and its implantation in Spain. It consists of thirteen participant countries with eight certified web portals, with another 5 under development and another two thematic ones. In February 2009 Scielo.org had 611 magazines and 195,789 articles of which 46% were about health sciences. Spain became a project member in 1999 and launched the SciELO web portal in 2001, as well as 4 magazines. It currently has 39 titles in the field of Health Sciences; one of which is the Revista Española de Sanidad Penitenciaria, which joined the project in 2007 and which currently has 6 issues from 2007 and 2008 available. This makes it one of the most important open access initiatives existing. The report concludes by stating that the SciELO model contributes to the development of research and science by offering an effective and efficient method of promoting and increasing the dissemination of scientific publications in Latin America.

  16. An Exploratory Analysis of the Potential Association Between SCI Secondary Health Conditions and Daily Activities

    PubMed Central

    Cobb, John; Dumont, Frédéric S.; Leblond, Jean; Park, So Eyun; Noonan, Vanessa K.

    2014-01-01

    Background: Secondary health conditions (SHCs) are common following traumatic spinal cord injury (tSCI) and are believed to influence a person’s ability to participate in daily activities (DAs). This association should be understood so that health care providers may target interventions with clarity and purpose to manage SHCs and facilitate DAs to maximal effect. Objective: To explore the association between SHCs and DAs expressed as the increased chance of not participating as much as wanted in a DA when an SHC is present. Methods: Community-dwelling persons with tSCI (n = 1,137) responded to the SCI Community Survey. The occurrence and frequency of 21 SHCs were determined. The extent of participation in 26 DAs was measured. The relative risk (RR) of not participating as much as wanted in a DA when a SHC is present was calculated. Results: When some SHC were present, the RR of not participating as much as wanted increased significantly (range, 15%-153%; P < .001). Certain SHCs (light-headedness/dizziness, fatigue, weight problems, constipation, shoulder problems) were associated with a greater chance of not participating in many DAs. No single SHC was associated with every DA and conversely not every DA was associated with an SHC. Conclusions: Maximizing participation in DAs requires minimizing SHCs in every instance. Understanding the association between SHCs and DAs may facilitate targeted care resulting in less severe SHCs, greater participation in DAs, and benefits to both the individual and society. PMID:25477741

  17. [Analysis on acupuncture literature in Science Citation Index (SCI) periodicals in 2007].

    PubMed

    Gao, Liang; Tian, Li-xin; Guo, Yi

    2009-06-01

    To grasp the international developing tendency of acupuncture research and provide some references for promoting acupuncture and moxibustion internationalization process, the articles about acupuncture in Science Citation Index (SCI) periodicals in 2007 were retrieved by adopting the retrieval tactics on line in combination with database searching. Results indicate that 257 articles about acupuncture had been retrived from the SCI Web databases. These articles were published in 125 journals respectively, most of which were Euramerican journals. Among these journals, the impact factor of the Journal of the American Medical Association (JAMA), 25. 547, is the highest one. It is shown that the impact factors of the SCI periodicals, in which acupuncture articles embodied are increased, the quality of these articles are improved obviously and the types of the articles are various in 2007, but there is obvious difference in the results of these studies due to the difference of experimental methods, the subjects of these experiments and acupuncture manipulations. Therefore, standardization of many problems arising from the researches on acupuncture is extremely imminent.

  18. Family dynamics and psychosocial functioning in children with SCI/D from Colombia, South America

    PubMed Central

    Nicolais, Christina J.; Perrin, Paul B.; Panyavin, Ivan; Nicholls, Elizabeth G.; Olivera Plaza, Silvia Leonor; Quintero, Lorena Medina; Arango-Lasprilla, Juan Carlos

    2016-01-01

    Objective The purpose of this study was to examine the connections between family dynamics and the psychosocial functioning of children with spinal cord injuries and disorders (SCI/D). Design Cross-sectional. Setting Participants were recruited from communities in Neiva, Colombia. Participants Thirty children with SCI/D and their primary caregiver participated. Children were between 8 and 17 years of age, and had sustained their injury at least six months prior to data collection. Interventions NA. Outcome measures Participating children completed measures assessing their own psychosocial functioning (Children's Depression Inventory, Revised Children's Manifest Anxiety Scale-2, Pediatric Quality of Life Inventory), and their primary caregiver completed measures of family dynamics (Family Adaptability and Cohesion Evaluation Scale- Fourth Edition, Family Communication Scale, Family Assessment Device- General Functioning, Family Satisfaction Scale, Relationship-Focused Coping Scale). Results A correlation matrix showed a number of significant bivariate correlations between child and family variables, and three multiple regressions showed that family satisfaction, empathy, and flexibility significantly explained 27% of the variance in child worry; family satisfaction and communication explained 18% of the variance in child social anxiety; and family cohesion and communication explained 23% of the variance in child emotional functioning. Conclusions These findings highlight the importance of rehabilitation professionals considering the association between family dynamics and the psychosocial functioning of children with SCI/D when working with this population. PMID:25582185

  19. GeoSciML v3.0 - a significant upgrade of the CGI-IUGS geoscience data model

    NASA Astrophysics Data System (ADS)

    Raymond, O.; Duclaux, G.; Boisvert, E.; Cipolloni, C.; Cox, S.; Laxton, J.; Letourneau, F.; Richard, S.; Ritchie, A.; Sen, M.; Serrano, J.-J.; Simons, B.; Vuollo, J.

    2012-04-01

    GeoSciML version 3.0 (http://www.geosciml.org), released in late 2011, is the latest version of the CGI-IUGS* Interoperability Working Group geoscience data interchange standard. The new version is a significant upgrade and refactoring of GeoSciML v2 which was released in 2008. GeoSciML v3 has already been adopted by several major international interoperability initiatives, including OneGeology, the EU INSPIRE program, and the US Geoscience Information Network, as their standard data exchange format for geoscience data. GeoSciML v3 makes use of recently upgraded versions of several Open Geospatial Consortium (OGC) and ISO data transfer standards, including GML v3.2, SWE Common v2.0, and Observations and Measurements v2 (ISO 19156). The GeoSciML v3 data model has been refactored from a single large application schema with many packages, into a number of smaller, but related, application schema modules with individual namespaces. This refactoring allows the use and future development of modules of GeoSciML (eg; GeologicUnit, GeologicStructure, GeologicAge, Borehole) in smaller, more manageable units. As a result of this refactoring and the integration with new OGC and ISO standards, GeoSciML v3 is not backwardly compatible with previous GeoSciML versions. The scope of GeoSciML has been extended in version 3.0 to include new models for geomorphological data (a Geomorphology application schema), and for geological specimens, geochronological interpretations, and metadata for geochemical and geochronological analyses (a LaboratoryAnalysis-Specimen application schema). In addition, there is better support for borehole data, and the PhysicalProperties model now supports a wider range of petrophysical measurements. The previously used CGI_Value data type has been superseded in favour of externally governed data types provided by OGC's SWE Common v2 and GML v3.2 data standards. The GeoSciML v3 release includes worked examples of best practice in delivering geochemical

  20. SciNews: Incorporating Science Current Events in 21st Century Classrooms

    NASA Astrophysics Data System (ADS)

    DiMaggio, E.

    2011-12-01

    Middle school students are instructed with the aid of textbooks, lectures, and activities to teach topics that satisfy state standards. However, teaching materials created to convey standard-aligned science concepts often leave students asking how the content relates to their lives and why they should be learning it. Conveying relevance is important for student learning and retention, especially in science where abstract concepts can often be incorrectly perceived as irrelevant. One way to create an educational link between classroom content and everyday life is through the use of scientific current events. Students read, hear, and watch media coverage of natural events (such as the 2011 earthquake and tsunami in Japan), but do not necessarily relate the scientific information from media sources to classroom studies. Taking advantage of these brief 'teachable moments'--when student interest is high--provides a valuable opportunity to make classroom-to-everyday life associations and to incorporate inquiry based learning. To address this need, I create pre-packaged current event materials for middle to high school teachers that align to state standards, and which are short, effective, and easy to implement in the classroom. Each lesson takes approximately 15-30 minutes to implement, allowing teachers time to facilitate brief but meaningful discussions. I assemble materials within approximately one week of the regional or global science event, consisting of short slide shows, maps, videos, pictures, and real-time data. I use a listserv to send biweekly emails to subscribed instructors containing the current event topic and a link to download the materials. All materials are hosted on the Arizona State University Education Outreach SciNews website (http://sese.asu.edu/teacher-resources) and are archived. Currently, 285 educators subscribe to the SciNews listserv, representing 36 states and 19 countries. In order to assess the effectiveness and usefulness of Sci

  1. The High-resolution Stereo Color Imager (HiSCI) on ExoMars Trace Gas Orbiter (TGO)

    NASA Astrophysics Data System (ADS)

    McEwen, A. S.; Thomas, N.; Bridges, J.; Byrne, S.; Cremonese, G.; Delamere, W.; Hansen, C.; Hauber, E.; Ivanov, A.; Kestay, L.; Kirk, R.; Mangold, N.; Markiewicz, W.; Massironi, M.; Mattson, S.; Okubo, C.; Wray, J.

    2011-10-01

    HiSCI has been chosen for the payload of the ExoMars Trace Gas Orbiter (TGO), a joint ESA/NASA mission scheduled to arrive at Mars in 2016 [1]. There are 3 major HiSCI partners: (1) the telescope assembly will be built in Switzerland overseen by the University of Bern; (2) the overall design, electronics, and integration will be by Ball Aerospace in Colorado; and (3) operations will be joint with MRO's High Resolution Imaging Science Experiment (HiRISE) [2] at the University of Arizona. HiSCI will acquire the best-ever colour and stereo images over significant areas of Mars.

  2. Antifungal activities of SCY-078 (MK-3118) and standard antifungal agents against clinical non-Aspergillus mold isolates.

    PubMed

    Lamoth, Frédéric; Alexander, Barbara D

    2015-07-01

    The limited armamentarium of active and oral antifungal drugs against emerging non-Aspergillus molds is of particular concern. Current antifungal agents and the new orally available beta-1,3-d-glucan synthase inhibitor SCY-078 were tested in vitro against 135 clinical non-Aspergillus mold isolates. Akin to echinocandins, SCY-078 showed no or poor activity against Mucoromycotina and Fusarium spp. However, SCY-078 was highly active against Paecilomyces variotii and was the only compound displaying some activity against notoriously panresistant Scedosporium prolificans.

  3. Publishing datasets with eSciDoc and panMetaDocs

    NASA Astrophysics Data System (ADS)

    Ulbricht, D.; Klump, J.; Bertelmann, R.

    2012-04-01

    Currently serveral research institutions worldwide undertake considerable efforts to have their scientific datasets published and to syndicate them to data portals as extensively described objects identified by a persistent identifier. This is done to foster the reuse of data, to make scientific work more transparent, and to create a citable entity that can be referenced unambigously in written publications. GFZ Potsdam established a publishing workflow for file based research datasets. Key software components are an eSciDoc infrastructure [1] and multiple instances of the data curation tool panMetaDocs [2]. The eSciDoc repository holds data objects and their associated metadata in container objects, called eSciDoc items. A key metadata element in this context is the publication status of the referenced data set. PanMetaDocs, which is based on PanMetaWorks [3], is a PHP based web application that allows to describe data with any XML-based metadata schema. The metadata fields can be filled with static or dynamic content to reduce the number of fields that require manual entries to a minimum and make use of contextual information in a project setting. Access rights can be applied to set visibility of datasets to other project members and allow collaboration on and notifying about datasets (RSS) and interaction with the internal messaging system, that was inherited from panMetaWorks. When a dataset is to be published, panMetaDocs allows to change the publication status of the eSciDoc item from status "private" to "submitted" and prepare the dataset for verification by an external reviewer. After quality checks, the item publication status can be changed to "published". This makes the data and metadata available through the internet worldwide. PanMetaDocs is developed as an eSciDoc application. It is an easy to use graphical user interface to eSciDoc items, their data and metadata. It is also an application supporting a DOI publication agent during the process of

  4. A Novel Approach for Effectively Treating SCI Pain, Improving Opioid Efficacy, and Preventing Opioid-Induced Constipation: Key Role of Toll-Like Receptor 4 (TLR4)

    DTIC Science & Technology

    2015-10-01

    pain ; however, morphine for 7 d post-SCI has little effect on chronic thermal nociceptive thresholds in this model. Establishing effects of post-SCI...AWARD NUMBER: W81XWH-13-1-0277 TITLE: A Novel Approach for Effectively Treating SCI Pain , Improving Opioid Efficacy, and Preventing Opioid...SCI Pain , Improving Opioid Efficacy, and Preventing Opioid-Induced Constipation: Key Role of Toll-Like Receptor 4 (TLR4) 5a. CONTRACT NUMBER 5b

  5. Collaborative Science Using Web Services and the SciFlo Grid Dataflow Engine

    NASA Astrophysics Data System (ADS)

    Wilson, B. D.; Manipon, G.; Xing, Z.; Yunck, T.

    2006-12-01

    The General Earth Science Investigation Suite (GENESIS) project is a NASA-sponsored partnership between the Jet Propulsion Laboratory, academia, and NASA data centers to develop a new suite of Web Services tools to facilitate multi-sensor investigations in Earth System Science. The goal of GENESIS is to enable large-scale, multi-instrument atmospheric science using combined datasets from the AIRS, MODIS, MISR, and GPS sensors. Investigations include cross-comparison of spaceborne climate sensors, cloud spectral analysis, study of upper troposphere-stratosphere water transport, study of the aerosol indirect cloud effect, and global climate model validation. The challenges are to bring together very large datasets, reformat and understand the individual instrument retrievals, co-register or re-grid the retrieved physical parameters, perform computationally-intensive data fusion and data mining operations, and accumulate complex statistics over months to years of data. To meet these challenges, we have developed a Grid computing and dataflow framework, named SciFlo, in which we are deploying a set of versatile and reusable operators for data access, subsetting, registration, mining, fusion, compression, and advanced statistical analysis. SciFlo leverages remote Web Services, called via Simple Object Access Protocol (SOAP) or REST (one-line) URLs, and the Grid Computing standards (WS-* &Globus Alliance toolkits), and enables scientists to do multi-instrument Earth Science by assembling reusable Web Services and native executables into a distributed computing flow (tree of operators). The SciFlo client &server engines optimize the execution of such distributed data flows and allow the user to transparently find and use datasets and operators without worrying about the actual location of the Grid resources. In particular, SciFlo exploits the wealth of datasets accessible by OpenGIS Consortium (OGC) Web Mapping Servers & Web Coverage Servers (WMS/WCS), and by Open Data

  6. The Fulldome Curriculum for the Spitz SciDome Digital Planetarium: Volume 2

    NASA Astrophysics Data System (ADS)

    Bradstreet, David H.; Sanders, S. J.; Huggins, S.

    2014-01-01

    The Spitz Fulldome Curriculum (FDC) for the SciDome digital planetarium ushered in a new and innovative way to present astronomical pedagogy via its use of the unique teaching attributes of the digital planetarium. In the case of the FDC, which uses the ubiquitous Starry Night planetarium software as its driving engine, these engaging and novel teaching techniques have also been made usable to desktop computers and flat-screen video projectors for classroom use. Volume 2 of the FDC introduces exciting new classes and mini-lessons to further enlighten and invigorate students as they struggle with often difficult three dimensional astronomical concepts. Additionally, other topics with related astronomical ties have been created to integrate history into planetarium presentations. One of the strongest advantages of the SciDome is its use of Starry Night as its astronomical engine. With it students can create their own astronomical configurations in the computer lab or at home, using the PC or Mac version. They can then simply load their creations onto the SciDome planetarium system and display them for their classmates on the dome. This poster will discuss and illustrate some of the new content that has been developed for Volume 2. Topics covered in Volume 2 include eclipses, plotting planet locations on a curtate orbit chart by observing their positions in the sky, time and timekeeping (including sidereal day, hour angles, sidereal time, LAST, LMST, time zones and the International Date Line), teaching to the Boy Scout Merit Badge requirements, plotting scale analemmas on the surface of planets and interpreting them, precession, astronomical events in revolutionary Boston, the Lincoln Almanac Trial, eclipsing binaries, lunar librations, a trip through the universe, watching the speed of light move in real time, stellar sizes and the Milky Way.

  7. Weight-supported treadmill vs over-ground training for walking after acute incomplete SCI

    PubMed Central

    Dobkin, B; Apple, D.; Barbeau, H.; Basso, M.; Behrman, A.; Deforge, D.; Ditunno, J.; Dudley, G.; Elashoff, R.; Fugate, L.; Harkema, S.; Saulino, M.; Scott, M.

    2014-01-01

    Objective To compare the efficacy of step training with body weight support on a treadmill (BWSTT) with over-ground practice to the efficacy of a defined over-ground mobility therapy (CONT) in patients with incomplete spinal cord injury (SCI) admitted for inpatient rehabilitation. Methods A total of 146 subjects from six regional centers within 8 weeks of SCI were entered in a single-blinded, multicenter, randomized clinical trial (MRCT). Subjects were graded on the American Spinal Injury Association Impairment Scale (ASIA) as B, C, or D with levels from C5 to L3 and had a Functional Independence Measure for locomotion (FIM-L) score <4. They received 12 weeks of equal time of BWSTT or CONT. Primary outcomes were FIM-L for ASIA B and C subjects and walking speed for ASIA C and D subjects 6 months after SCI. Results No significant differences were found at entry between treatment groups or at 6 months for FIM-L (n = 108) or walking speed and distance (n = 72). In the upper motor neuron (UMN) subjects, 35% of ASIA B, 92% of ASIA C, and all ASIA D subjects walked independently. Velocities for UMN ASIA C and D subjects were not significantly different for BWSTT (1.1 ± 0.6 m/s, n = 30) and CONT (1.1 ± 0.7, n = 25) groups. Conclusions The physical therapy strategies of body weight support on a treadmill and defined overground mobility therapy did not produce different outcomes. This finding was partly due to the unexpectedly high percentage of American Spinal Injury Association C subjects who achieved functional walking speeds, irrespective of treatment. The results provide new insight into disability after incomplete spinal cord injury and affirm the importance of the multicenter, randomized clinical trial to test rehabilitation strategies. PMID:16505299

  8. Studying the History of the Intergalactic Medium with the SCI-HI Experiment

    NASA Astrophysics Data System (ADS)

    Voytek, Tabitha Christine

    The Cosmic Dawn (z ˜ 15 -- 35) is the period in the history of our universe when stars first began to form in small Dark Matter minihalos. Light from these first stars is too dim for telescopes to see, which means that the Cosmic Dawn has never been directly measured. However, the first stars impacted the gas, or intergalactic medium (IGM), around them. The impact of the first stars was heating and eventual ionization of the IGM. The process of heating and ionization creates a spectrum that varies over redshift, namely the spatially averaged brightness temperature spectrum of 21-cm light from the IGM. Measurement of this spectrum will give us a first glimpse of the Cosmic Dawn. The "Sonda Cosmologica de las Islas para la Deteccion de Hidrogeno Neutro" (SCIHI) experiment is a collaboration between Carnegie Mellon University (CMU) and Instituto Nacional de Astrofisica, Optica y Electronica (INAOE) in Mexico and was designed to make this measurement. The SCI-HI experiment is a small-scale system which travels with the team to remote locations for deployments. These remote locations are necessary to avoid radio frequency interference and other environmental impacts on the system. This thesis describes the development and deployment of the SCI-HI experiment. It starts with the original design and covers development of the system over time. Deployment location selection is then discussed, including the results of site evaluations. In addition, the thesis outlines the data analysis process used for the system and shows results from data collected during the June 2013 deployment of the experiment. Finally, the thesis describes plans for the future of the SCI-HI experiment, including deployment to South Africa in 2015.

  9. A Characterization Of The GNAT SciTech STAR Class 0.5m Prototype Telescope

    NASA Astrophysics Data System (ADS)

    Barentine, J. C.; Culver, R. B.

    2002-05-01

    In 1995 the Global Network of Automated Telescopes (GNAT) acquired an option to purchase a 0.5m "STAR" class telescope, manufactured by SciTech Corporation of Forresthill, CA, contingent upon its attainment of performance specifications published by SciTech. In spite of a concerted, and protracted effort, the telescope has not yet approached the manufacturer's specifications, and has proven largely unusable for its intended purpose. In light of the difficult history of commercial development of true automated telescopes (see Sinnott 1996 and Henry 1994) it is important to understand the current state of such commercial systems. We present results of a characterization of this telescope and recommendations for how to proceed in light of its failure to attain specifications. Principle failings of the telescope can be summarized as follows: 1) the mechanical structure was inadequately designed and built, yielding large and unacceptable pointing and tracking errors, 2) the autoguider system was never successfully implemented, limiting the system to very short integrations, 3) the autofocus mechanism was never successfully implemented, resulting in periodic, unacceptable focus drifts during automatic operation, 4) the telescope control system as provided with the telescope did not work and ultimately had to be developed by an independent contractor recommended by GNAT and contracted through SciTech, and 5) the telescope optical system design did not adequately accommodate scattered light issues, yielding significant scattered light contributions to the images under certain conditions. Based on analyses of these issues, we present recommendations for improvements in this system. Support of this work has been provided by Colorado State University and GNAT. REFERENCES Sinnott, R.W. Sky And Telescope vol.91, no.6, p.38 (1996) Henry, G.W. IAPPP Communication No.57, Autumn 1994, p.57

  10. MicroRNA-146a Contributes to SCI Recovery via Regulating TRAF6 and IRAK1 Expression

    PubMed Central

    Wei, Jinsong; Zhou, Yulan; Yan, Shouquan

    2016-01-01

    MicroRNA-146a participates in spinal cord injury (SCI) recovery. Until recently, how miRNA-146a participates in SCI remained unclear. In this study, we tried to explore the roles of miRNA-146a in the recovery of SCI using a rat model. The expression of the probable target genes of miRNA-146a (including IRAK1 and TARF6) as well as proinflammation cytokines were measured until 7 days after surgery in the three groups (sham group, SCI group, and miRNA-146a antagomir injection group). Also, the animals' motivations were estimated using Basso Beattie Bresnahan (BBB) during the whole experiment. A luciferase assay was performed to demonstrate that miRNA-146a could directly target the mRNAs of IRAK1 and TRAF6. Our experiments indicate that miRNA-146a inhibits proinflammatory cytokine secretion by suppressing IRAK1 and TRAF6 expression in the SCI model. In contrast, miRNA-146a may be upregulated by inflammatory mediators via the IRAK1/TRAF6 pathway in the spinal cord. As a negative feedback element, miRNA-146a could make sure that the expression of IRAK1- and TRAF6-mediated genes was under tight control. Thus, miRNA-146a may serve as a novel therapeutic target for SCI interventions. PMID:27830143

  11. SciSpark: Highly Interactive and Scalable Model Evaluation and Climate Metrics

    NASA Astrophysics Data System (ADS)

    Wilson, B. D.; Palamuttam, R. S.; Mogrovejo, R. M.; Whitehall, K. D.; Mattmann, C. A.; Verma, R.; Waliser, D. E.; Lee, H.

    2015-12-01

    Remote sensing data and climate model output are multi-dimensional arrays of massive sizes locked away in heterogeneous file formats (HDF5/4, NetCDF 3/4) and metadata models (HDF-EOS, CF) making it difficult to perform multi-stage, iterative science processing since each stage requires writing and reading data to and from disk. We are developing a lightning fast Big Data technology called SciSpark based on ApacheTM Spark under a NASA AIST grant (PI Mattmann). Spark implements the map-reduce paradigm for parallel computing on a cluster, but emphasizes in-memory computation, "spilling" to disk only as needed, and so outperforms the disk-based ApacheTM Hadoop by 100x in memory and by 10x on disk. SciSpark will enable scalable model evaluation by executing large-scale comparisons of A-Train satellite observations to model grids on a cluster of 10 to 1000 compute nodes. This 2nd generation capability for NASA's Regional Climate Model Evaluation System (RCMES) will compute simple climate metrics at interactive speeds, and extend to quite sophisticated iterative algorithms such as machine-learning based clustering of temperature PDFs, and even graph-based algorithms for searching for Mesocale Convective Complexes. We have implemented a parallel data ingest capability in which the user specifies desired variables (arrays) as several time-sorted lists of URL's (i.e. using OPeNDAP model.nc?varname, or local files). The specified variables are partitioned by time/space and then each Spark node pulls its bundle of arrays into memory to begin a computation pipeline. We also investigated the performance of several N-dim. array libraries (scala breeze, java jblas & netlib-java, and ND4J). We are currently developing science codes using ND4J and studying memory behavior on the JVM. On the pyspark side, many of our science codes already use the numpy and SciPy ecosystems. The talk will cover: the architecture of SciSpark, the design of the scientific RDD (sRDD) data structure, our

  12. SciSpark: Highly Interactive and Scalable Model Evaluation and Climate Metrics

    NASA Astrophysics Data System (ADS)

    Wilson, B. D.; Mattmann, C. A.; Waliser, D. E.; Kim, J.; Loikith, P.; Lee, H.; McGibbney, L. J.; Whitehall, K. D.

    2014-12-01

    Remote sensing data and climate model output are multi-dimensional arrays of massive sizes locked away in heterogeneous file formats (HDF5/4, NetCDF 3/4) and metadata models (HDF-EOS, CF) making it difficult to perform multi-stage, iterative science processing since each stage requires writing and reading data to and from disk. We are developing a lightning fast Big Data technology called SciSpark based on ApacheTM Spark. Spark implements the map-reduce paradigm for parallel computing on a cluster, but emphasizes in-memory computation, "spilling" to disk only as needed, and so outperforms the disk-based ApacheTM Hadoop by 100x in memory and by 10x on disk, and makes iterative algorithms feasible. SciSpark will enable scalable model evaluation by executing large-scale comparisons of A-Train satellite observations to model grids on a cluster of 100 to 1000 compute nodes. This 2nd generation capability for NASA's Regional Climate Model Evaluation System (RCMES) will compute simple climate metrics at interactive speeds, and extend to quite sophisticated iterative algorithms such as machine-learning (ML) based clustering of temperature PDFs, and even graph-based algorithms for searching for Mesocale Convective Complexes. The goals of SciSpark are to: (1) Decrease the time to compute comparison statistics and plots from minutes to seconds; (2) Allow for interactive exploration of time-series properties over seasons and years; (3) Decrease the time for satellite data ingestion into RCMES to hours; (4) Allow for Level-2 comparisons with higher-order statistics or PDF's in minutes to hours; and (5) Move RCMES into a near real time decision-making platform. We will report on: the architecture and design of SciSpark, our efforts to integrate climate science algorithms in Python and Scala, parallel ingest and partitioning (sharding) of A-Train satellite observations from HDF files and model grids from netCDF files, first parallel runs to compute comparison statistics and PDF

  13. [Analysis of acupuncture literatures published in Science Citation Index (SCI) periodicals in 2010].

    PubMed

    Xiang, Yan; Li, Rui

    2012-08-01

    Acupuncture-related literatures published in foreign medical journal in Science Citation Index (SCI) periodicals in 2010 were retrieved, summarized and analyzed. The result shows that the recognition of acupuncture clinic abroad was still in the initial period. Most of the researches were still remained in the section of clinical efficacy verification. There was comparatively less studies on its working mechanism. Traditional treatments according to differentiation of syndromes were still deficient in clinical researches. There were big differences on research results, however, most of the result equated therapeutic effect of acupuncture with placeboes. And it was lack of unified and standard estimation system on the effect of acupuncture.

  14. Measurement of Neutron and Muon Fluxes 100~m Underground with the SciBath Detector

    SciTech Connect

    Garrison, Lance

    2014-01-01

    The SciBath detector is an 80 liter liquid scintillator detector read out by a three dimensional grid of 768 wavelength-shifting fibers. Initially conceived as a fine-grained charged particle detector for neutrino studies that could image charged particle tracks in all directions, it is also sensitive to fast neutrons (15-200 MeV). In fall of 2011 the apparatus performed a three month run to measure cosmic-induced muons and neutrons 100~meters underground in the FNAL MINOS near-detector area. Data from this run has been analyzed and resulted in measurements of the cosmic muon flux as \

  15. Highlights from day three of the EuroSciCon 2015 Sports Science Summit

    PubMed Central

    Chawla, Amit; McGregor, Alison

    2015-01-01

    This EuroSciCon Sports Science Summit represented a significant gathering of leading professionals in the field of sports science. The conference was held on 13–15 January 2015 at the O2 arena, London, UK. The chairman on the third day was Mr Greg Robertson, a specialist trainee Orthopedic surgeon from Edinburgh. The conference attracted over 80 attendants from all over the world, with 32 presentations from invited speakers and peer-reviewed submissions. This meeting report provides a summary of the best abstracts from the conference. PMID:28031889

  16. Transposon-Assisted Genetic Engineering with Mos1-Mediated Single-Copy Insertion (MosSCI).

    PubMed

    Frøkjær-Jensen, Christian

    2015-01-01

    Transgenesis in model organisms is necessary to determine the function, expression, and subcellular localization of gene products. In Caenorhabditis elegans, injected DNA can be propagated as multicopy extrachromosomal arrays but transgenes in arrays are mosaic, over-expressed in some tissues and silenced in the germline. Here, a method to insert a transgene into a specific genomic location called Mos1-mediated single-copy insertion (MosSCI) is described. Single-copy insertion allows transgene expression at levels that approximate endogenous gene expression as well as expression in the germline.

  17. [Analysis on acupuncture related articles published in periodicals in science citation index (SCI) in 2008].

    PubMed

    Wang, Chao; He, Wen-Ju; Guo, Yi

    2010-09-01

    Acupuncture related articles published in periodicals in Science Citation Index (SCI) in 2008 were summarized and analyzed. About 583 articles were collected using "acupuncture" and "in 2008" as keywords in the Web of Science data base by information retrieval. These papers were summarized and analyzed from various aspects of country, language, subject category, literature type, publication sources, impact factor, research method, acupoints, disease category and needling methods by using Excel software combined with manual sorting of the literature, the aim is to provide a reference for domestic acupuncture research.

  18. SciFinder Scholar 2006: an empirical analysis of research topic query processing.

    PubMed

    Wagner, A Ben

    2006-01-01

    Topical search queries in SciFinder Scholar are processed through an extensive set of natural language processing algorithms that greatly enhance the relevance and comprehensiveness of the search results. Little detailed documentation on these algorithms has been published. However, a careful examination of the highlighted hit terms coupled with a comparison of results from small variations in query language reveal much additional, useful information about these algorithms. An understanding of how these algorithms work can lead to better search results and explain many unexpected results, including differing hit counts for singular versus plural query words and phrases.

  19. What's Manifest in the History of SciTech: Reflections on The History Manifesto.

    PubMed

    Kevles, Daniel J

    2016-06-01

    Making nuts-and-bolts public policy is not--and never has been--the long suit of professional historians, but general historical work, whatever its durée, has done a good deal to shape discourse on public issues. Jo Guldi and David Armitage neglect that fact, as well as the opinion-shaping influence of history conveyed via nonprint media. They also ignore the large body of scholarship produced in all media during recent decades in the history of science, technology, and science-related medicine (SciTech), even though SciTech itself looms enormously large in the modern era as an instrument of national and international security, a driver of the economy, and a transformer of medicine, public health, and the environment. Much of this scholarship, even though of short durée, can illuminate salient contemporary issues, including innovation; patronage and practice; government and policy; imperialism and globalization; intellectual property; science and religion; and human rights, environment, energy, and disasters.

  20. Performance Engineering Research Institute SciDAC-2 Enabling Technologies Institute Final Report

    SciTech Connect

    Hall, Mary

    2014-09-19

    Enhancing the performance of SciDAC applications on petascale systems has high priority within DOE SC. As we look to the future, achieving expected levels of performance on high-end com-puting (HEC) systems is growing ever more challenging due to enormous scale, increasing archi-tectural complexity, and increasing application complexity. To address these challenges, PERI has implemented a unified, tripartite research plan encompassing: (1) performance modeling and prediction; (2) automatic performance tuning; and (3) performance engineering of high profile applications. The PERI performance modeling and prediction activity is developing and refining performance models, significantly reducing the cost of collecting the data upon which the models are based, and increasing model fidelity, speed and generality. Our primary research activity is automatic tuning (autotuning) of scientific software. This activity is spurred by the strong user preference for automatic tools and is based on previous successful activities such as ATLAS, which has automatically tuned components of the LAPACK linear algebra library, and other re-cent work on autotuning domain-specific libraries. Our third major component is application en-gagement, to which we are devoting approximately 30% of our effort to work directly with Sci-DAC-2 applications. This last activity not only helps DOE scientists meet their near-term per-formance goals, but also helps keep PERI research focused on the real challenges facing DOE computational scientists as they enter the Petascale Era.

  1. Building a Universal Nuclear Energy Density Functional (UNEDF). SciDAC-2 Project

    SciTech Connect

    Vary, James P.; Carlson, Joe; Furnstahl, Dick; Horoi, Mihai; Lusk, Rusty; Nazarewicz, Witek; Ng, Esmond; Thompson, Ian

    2012-09-29

    An understanding of the properties of atomic nuclei is crucial for a complete nuclear theory, for element formation, for properties of stars, and for present and future energy and defense applications. During the period of Dec. 1 2006 – Jun. 30, 2012, the UNEDF collaboration carried out a comprehensive study of all nuclei, based on the most accurate knowledge of the strong nuclear interaction, the most reliable theoretical approaches, the most advanced algorithms, and extensive computational resources, with a view towards scaling to the petaflop platforms and beyond. Until recently such an undertaking was hard to imagine, and even at the present time such an ambitious endeavor would be far beyond what a single researcher or a traditional research group could carry out. The UNEDF SciDAC project has developed several key computational codes and algorithms for reaching the goal of solving the nuclear quantum many-body problem throughout the chart of nuclei. Without such developments, scientific progress would not be possible. In addition the UNEDF SciDAC successfully applied these developments to solve many forefront research problems.

  2. Scientific support of SciTech museum exhibits and outreach programs

    SciTech Connect

    Peshkin, M.

    1995-08-01

    SciTech (Science and Technology Interactive Center) is a small hands-on science museum located in Aurora, Illinois, not far from Argonne National Laboratory. Its constituency includes prosperous suburbs and economically disadvantaged minority communities in Aurora and Chicago. Its mission is to contribute to the country`s scientific literacy initiative by offering hands-on experiences on the museum floor and through outreach programs extended to school children, their teachers, and other groups. Argonne`s participation is focused mainly on the development of exhibits to carry the ideas of modern science and technology to the public. This is an area in which traditional museums are weak, but in which SciTech has become a nationally recognized leader with the assistance of Argonne, Fermilab, nearby technological companies, and many volunteer scientists and engineers. We also participate in development and improvement of the museum`s general exhibits and outreach programs. Argonne`s Director, Alan Schriesheim, serves as a member of the museum`s Board of Directors. Murray Peshkin serves part-time as the museum`s Senior Scientist. Dale Henderson serves part-time as an exhibit developer. That work is supported by the Laboratory Director`s discretionary funds. In addition, several members of the Physics Division voluntarily assist with exhibit development and the Division makes facilities available for that effort.

  3. SciDAC - The Scientific Data Management Center (http://sdmcenter.lbl.gov)

    SciTech Connect

    Ling Liu Calton Pu

    2005-06-20

    In SciDAC SDM project, the main assignment to the Georgia Institute of Technology team (according to the proposed work) is to develop advanced information extraction and information integration technologies on top of the XWRAP technology originated from Georgia Tech [LPH01]. We have developed XWRAPComposer technology to enable the XWRAP code generator to generate Java information wrappers that are capable of extraction of data from multiple linked pages. These information wrappers are used as gateways or adaptors for scientific information mediators to access and fuse interesting data and answering complex queries over a large collection of heterogeneous scientific information sources. Our accomplishments over the SciDAC sponsored years (July 2001 to July 2004) can be summarized along two dimensions. Technically, we have produced a number of major software releases and published over 30 research papers in both international conferences and international journals. The planned software releases include 1. Five Java wrappers and five WDSL-enabled wrappers for SDM Pilot scenarios, which were released in early 2003, 2. The XWRAPComposer toolkit (command line version) which was first released in late 2003 and then released in Summer 2004, 3. Five Ptolemy wrapper actors which were released first in Summer 2003, and then released again in Fall 2005. 4. The decomposable XWRAPComposer actor in Ptolemy, which we have made it available as open source in end of 2004 and tested it in early 2005.

  4. Neuroinflammatory contributions to pain after SCI: roles for central glial mechanisms and nociceptor-mediated host defense.

    PubMed

    Walters, Edgar T

    2014-08-01

    Neuropathic pain after spinal cord injury (SCI) is common, often intractable, and can be severely debilitating. A number of mechanisms have been proposed for this pain, which are discussed briefly, along with methods for revealing SCI pain in animal models, such as the recently applied conditioned place preference test. During the last decade, studies of animal models have shown that both central neuroinflammation and behavioral hypersensitivity (indirect reflex measures of pain) persist chronically after SCI. Interventions that reduce neuroinflammation have been found to ameliorate pain-related behavior, such as treatment with agents that inhibit the activation states of microglia and/or astroglia (including IL-10, minocycline, etanercept, propentofylline, ibudilast, licofelone, SP600125, carbenoxolone). Reversal of pain-related behavior has also been shown with disruption by an inhibitor (CR8) and/or genetic deletion of cell cycle-related proteins, deletion of a truncated receptor (trkB.T1) for brain-derived neurotrophic factor (BDNF), or reduction by antisense knockdown or an inhibitor (AMG9810) of the activity of channels (TRPV1 or Nav1.8) important for electrical activity in primary nociceptors. Nociceptor activity is known to drive central neuroinflammation in peripheral injury models, and nociceptors appear to be an integral component of host defense. Thus, emerging results suggest that spinal and systemic effects of SCI can activate nociceptor-mediated host defense responses that interact via neuroinflammatory signaling with complex central consequences of SCI to drive chronic pain. This broader view of SCI-induced neuroinflammation suggests new targets, and additional complications, for efforts to develop effective treatments for neuropathic SCI pain.

  5. Brain Transcriptional Responses to High-Fat Diet in Acads-Deficient Mice Reveal Energy Sensing Pathways

    PubMed Central

    Kruger, Claudia; Kumar, K. Ganesh; Mynatt, Randall L.; Volaufova, Julia; Richards, Brenda K.

    2012-01-01

    Background How signals from fatty acid metabolism are translated into changes in food intake remains unclear. Previously we reported that mice with a genetic inactivation of Acads (acyl-coenzyme A dehydrogenase, short-chain), the enzyme responsible for mitochondrial beta-oxidation of C4–C6 short-chain fatty acids (SCFAs), shift consumption away from fat and toward carbohydrate when offered a choice between diets. In the current study, we sought to indentify candidate genes and pathways underlying the effects of SCFA oxidation deficiency on food intake in Acads−/− mice. Methodology/Principal Findings We performed a transcriptional analysis of gene expression in brain tissue of Acads−/− and Acads+/+ mice fed either a high-fat (HF) or low-fat (LF) diet for 2 d. Ingenuity Pathway Analysis revealed three top-scoring pathways significantly modified by genotype or diet: oxidative phosphorylation, mitochondrial dysfunction, and CREB signaling in neurons. A comparison of statistically significant responses in HF Acads−/− vs. HF Acads+/+ (3917) and Acads+/+ HF vs. LF Acads+/+ (3879) revealed 2551 genes or approximately 65% in common between the two experimental comparisons. All but one of these genes were expressed in opposite direction with similar magnitude, demonstrating that HF-fed Acads-deficient mice display transcriptional responses that strongly resemble those of Acads+/+ mice fed LF diet. Intriguingly, genes involved in both AMP-kinase regulation and the neural control of food intake followed this pattern. Quantitative RT-PCR in hypothalamus confirmed the dysregulation of genes in these pathways. Western blotting showed an increase in hypothalamic AMP-kinase in Acads−/− mice and HF diet increased, a key protein in an energy-sensing cascade that responds to depletion of ATP. Conclusions Our results suggest that the decreased beta-oxidation of short-chain fatty acids in Acads-deficient mice fed HF diet produces a state of energy deficiency in the

  6. Transporter Protein-Coupled DPCPX Nanoconjugates Induce Diaphragmatic Recovery after SCI by Blocking Adenosine A1 Receptors

    PubMed Central

    Minic, Zeljka; Zhang, Yanhua; Mao, Guangzhao

    2016-01-01

    Respiratory complications in patients with spinal cord injury (SCI) are common and have a negative impact on the quality of patients' lives. Systemic administration of drugs that improve respiratory function often cause deleterious side effects. The present study examines the applicability of a novel nanotechnology-based drug delivery system, which induces recovery of diaphragm function after SCI in the adult rat model. We developed a protein-coupled nanoconjugate to selectively deliver by transsynaptic transport small therapeutic amounts of an A1 adenosine receptor antagonist to the respiratory centers. A single administration of the nanoconjugate restored 75% of the respiratory drive at 0.1% of the systemic therapeutic drug dose. The reduction of the systemic dose may obviate the side effects. The recovery lasted for 4 weeks (the longest period studied). These findings have translational implications for patients with respiratory dysfunction after SCI. SIGNIFICANCE STATEMENT The leading causes of death in humans following SCI are respiratory complications secondary to paralysis of respiratory muscles. Systemic administration of methylxantines improves respiratory function but also leads to the development of deleterious side effects due to actions of the drug on nonrespiratory sites. The importance of the present study lies in the novel drug delivery approach that uses nanotechnology to selectively deliver recovery-inducing drugs to the respiratory centers exclusively. This strategy allows for a reduction in the therapeutic drug dose, which may reduce harmful side effects and markedly improve the quality of life for SCI patients. PMID:27013674

  7. Development and psychometric characteristics of the SCI-QOL Bladder Management Difficulties and Bowel Management Difficulties item banks and short forms and the SCI-QOL Bladder Complications scale

    PubMed Central

    Tulsky, David S.; Kisala, Pamela A.; Tate, Denise G.; Spungen, Ann M.; Kirshblum, Steven C.

    2015-01-01

    Objective To describe the development and psychometric properties of the Spinal Cord Injury – Quality of Life (SCI-QOL) Bladder Management Difficulties and Bowel Management Difficulties item banks and Bladder Complications scale. Design Using a mixed-methods design, a pool of items assessing bladder and bowel-related concerns were developed using focus groups with individuals with spinal cord injury (SCI) and SCI clinicians, cognitive interviews, and item response theory (IRT) analytic approaches, including tests of model fit and differential item functioning. Setting Thirty-eight bladder items and 52 bowel items were tested at the University of Michigan, Kessler Foundation Research Center, the Rehabilitation Institute of Chicago, the University of Washington, Craig Hospital, and the James J. Peters VA Medical Center, Bronx, NY. Participants Seven hundred fifty-seven adults with traumatic SCI. Results The final item banks demonstrated unidimensionality (Bladder Management Difficulties CFI = 0.965; RMSEA = 0.093; Bowel Management Difficulties CFI = 0.955; RMSEA = 0.078) and acceptable fit to a graded response IRT model. The final calibrated Bladder Management Difficulties bank includes 15 items, and the final Bowel Management Difficulties item bank consists of 26 items. Additionally, 5 items related to urinary tract infections (UTI) did not fit with the larger Bladder Management Difficulties item bank but performed relatively well independently (CFI = 0.992, RMSEA = 0.050) and were thus retained as a separate scale. Conclusion The SCI-QOL Bladder Management Difficulties and Bowel Management Difficulties item banks are psychometrically robust and are available as computer adaptive tests or short forms. The SCI-QOL Bladder Complications scale is a brief, fixed-length outcomes instrument for individuals with a UTI. PMID:26010964

  8. ScyFlow: An Environment for the Visual Specification and Execution of Scientific Workflows

    NASA Technical Reports Server (NTRS)

    McCann, Karen M.; Yarrow, Maurice; DeVivo, Adrian; Mehrotra, Piyush

    2004-01-01

    With the advent of grid technologies, scientists and engineers are building more and more complex applications to utilize distributed grid resources. The core grid services provide a path for accessing and utilizing these resources in a secure and seamless fashion. However what the scientists need is an environment that will allow them to specify their application runs at a high organizational level, and then support efficient execution across any given set or sets of resources. We have been designing and implementing ScyFlow, a dual-interface architecture (both GUT and APT) that addresses this problem. The scientist/user specifies the application tasks along with the necessary control and data flow, and monitors and manages the execution of the resulting workflow across the distributed resources. In this paper, we utilize two scenarios to provide the details of the two modules of the project, the visual editor and the runtime workflow engine.

  9. SciData: a data model and ontology for semantic representation of scientific data.

    PubMed

    Chalk, Stuart J

    2016-01-01

    With the move toward global, Internet enabled science there is an inherent need to capture, store, aggregate and search scientific data across a large corpus of heterogeneous data silos. As a result, standards development is needed to create an infrastructure capable of representing the diverse nature of scientific data. This paper describes a fundamental data model for scientific data that can be applied to data currently stored in any format, and an associated ontology that affords semantic representation of the structure of scientific data (and its metadata), upon which discipline specific semantics can be applied. Application of this data model to experimental and computational chemistry data are presented, implemented using JavaScript Object Notation for Linked Data. Full examples are available at the project website (Chalk in SciData: a scientific data model. http://stuchalk.github.io/scidata/, 2016).

  10. VACET: Proposed SciDAC2 Visualization and Analytics Center forEnabling Technologies

    SciTech Connect

    Bethel, W.; Johnson, Chris; Hansen, Charles; Parker, Steve; Sanderson, Allen; Silva, Claudio; Tricoche, Xavier; Pascucci, Valerio; Childs, Hank; Cohen, Jonathon; Duchaineau, Mark; Laney, Dan; Lindstrom,Peter; Ahern, Sean; Meredith, Jeremy; Ostrouchov, George; Joy, Ken; Hamann, Bernd

    2006-06-19

    This paper accompanies a poster that is being presented atthe SciDAC 2006 meeting in Denver, CO. This project focuses on leveragingscientific visualization and analytics software technology as an enablingtechnology for increasing scientific productivity and insight. Advancesincomputational technology have resultedin an "information big bang,"which in turn has createda significant data understanding challenge. Thischallenge is widely acknowledged to be one of the primary bottlenecks incontemporary science. The vision for our Center is to respond directly tothat challenge by adapting, extending, creating when necessary anddeploying visualization and data understanding technologies for ourscience stakeholders. Using an organizational model as a Visualizationand Analytics Center for Enabling Technologies (VACET), we are wellpositioned to be responsive to the needs of a diverse set of scientificstakeholders in a coordinated fashion using a range of visualization,mathematics, statistics, computer and computational science and datamanagement technologies.

  11. Open for collaboration: an academic platform for drug discovery and development at SciLifeLab.

    PubMed

    Arvidsson, Per I; Sandberg, Kristian; Forsberg-Nilsson, Karin

    2016-10-01

    The Science for Life Laboratory Drug Discovery and Development (SciLifeLab DDD) platform reaches out to Swedish academia with an industry-standard infrastructure for academic drug discovery, supported by earmarked funds from the Swedish government. In this review, we describe the build-up and operation of the platform, and reflect on our first two years of operation, with the ambition to share learnings and best practice with academic drug discovery centers globally. We also discuss how the Swedish Teacher Exemption Law, an internationally unique aspect of the innovation system, has shaped the operation. Furthermore, we address how this investment in infrastructure and expertise can be utilized to facilitate international collaboration between academia and industry in the best interest of those ultimately benefiting the most from translational pharmaceutical research - the patients.

  12. Recent progress in CdTe solar cell research at SCI

    NASA Astrophysics Data System (ADS)

    Sasala, R. A.; Powell, R. C.; Dorer, G. L.; Reiter, N.

    1997-02-01

    Research at Solar Cells Inc. is focused on developing processes which will lead to high volume and low cost manufacturing of solar cells and to increase the performance of our present technology. The process research has focused on developing vapor transport deposition of the semiconductors, eliminating wet chemistry steps while minimizing the chloride treatment time, forming a low-loss back contact using only dry processing, and an improved interconnection technique. The performance improvement work has focused on the increase of the photocurrent by a combination of more transparent glass substrates and a thinner CdS window layer deposited on an i-SnO2 buffer layer. SCI record 13.0% 1 cm2 devices have been fabricated using these techniques. Stability monitoring continues and shows minimal degradation for over 20,000 hours of continuous light soak at 0.8 sun illumination.

  13. The Virtual Earth-Solar Observatory of the SCiESMEX

    NASA Astrophysics Data System (ADS)

    De la Luz, V.; Gonzalez-Esparza, A.; Cifuentes-Nava, G.

    2015-12-01

    The Mexican Space Weather Service (SCiESMEX, http://www.sciesmex.unam.mx) started operations in October 2014. The project includes the Virtual Earth-Solar Observatory (VESO, http://www.veso.unam.mx). The VESO is a improved project wich objetive is integrate the space weather instrumentation network from the National Autonomous University of Mexico (UNAM). The network includes the Mexican Array Radiotelescope (MEXART), the Callisto receptor (MEXART), a Neutron Telescope, a Cosmic Ray Telescope. the Schumann Antenna, the National Magnetic Service, and the mexican GPS network (TlalocNet). The VESO facility is located at the Geophysics Institute campus Michoacan (UNAM). We offer the service of data store, real-time data, and quasi real-time data. The hardware of VESO includes a High Performance Computer (HPC) dedicated specially to big data storage.

  14. Extraordinary tools for extraordinary science: the impact of SciDAC on accelerator science and technology

    NASA Astrophysics Data System (ADS)

    Ryne, Robert D.

    2006-09-01

    Particle accelerators are among the most complex and versatile instruments of scientific exploration. They have enabled remarkable scientific discoveries and important technological advances that span all programs within the DOE Office of Science (DOE/SC). The importance of accelerators to the DOE/SC mission is evident from an examination of the DOE document, ''Facilities for the Future of Science: A Twenty-Year Outlook.'' Of the 28 facilities listed, 13 involve accelerators. Thanks to SciDAC, a powerful suite of parallel simulation tools has been developed that represent a paradigm shift in computational accelerator science. Simulations that used to take weeks or more now take hours, and simulations that were once thought impossible are now performed routinely. These codes have been applied to many important projects of DOE/SC including existing facilities (the Tevatron complex, the Relativistic Heavy Ion Collider), facilities under construction (the Large Hadron Collider, the Spallation Neutron Source, the Linac Coherent Light Source), and to future facilities (the International Linear Collider, the Rare Isotope Accelerator). The new codes have also been used to explore innovative approaches to charged particle acceleration. These approaches, based on the extremely intense fields that can be present in lasers and plasmas, may one day provide a path to the outermost reaches of the energy frontier. Furthermore, they could lead to compact, high-gradient accelerators that would have huge consequences for US science and technology, industry, and medicine. In this talk I will describe the new accelerator modeling capabilities developed under SciDAC, the essential role of multi-disciplinary collaboration with applied mathematicians, computer scientists, and other IT experts in developing these capabilities, and provide examples of how the codes have been used to support DOE/SC accelerator projects.

  15. PACIFIC: the readout ASIC for the SciFi Tracker of the upgraded LHCb detector

    NASA Astrophysics Data System (ADS)

    Mazorra, J.; Chanal, H.; Comerma, A.; Gascón, D.; Gómez, S.; Han, X.; Pillet, N.; Vandaele, R.

    2016-02-01

    The LHCb detector will be upgraded during the Long Shutdown 2 (LS2) of the LHC in order to cope with higher instantaneous luminosities and will switch to a 40 MHz readout rate using a trigger-less software based system. All front-end electronics will be replaced and several sub-detectors must be redesigned to cope with the higher detector occupancy and radiation damage. The current tracking detectors downstream of the LHCb dipole magnet will be replaced by the Scintillating Fibre (SciFi) Tracker. The SciFi Tracker will use scintillating fibres read out by Silicon Photomultipliers (SiPMs). State-of-the-art multi-channel SiPM arrays are being developed and a custom ASIC, called the low-Power ASIC for the sCIntillating FIbres traCker (PACIFIC), will be used to digitise the signals from the SiPMs. This article presents an overview of the R&D for the PACIFIC. It is a 64-channel ASIC implemented in 130 nm CMOS technology, aiming at a radiation tolerant design with a power consumption below 10 mW per channel. It interfaces directly with the SiPM anode through a current mode input, and provides a configurable non-linear 2-bit per channel digital output. The SiPM signal is acquired by a current conveyor and processed with a fast shaper and a gated integrator. The digitization is performed using a three threshold non-linear flash ADC operating at 40 MHz. Simulation and test results show the PACIFIC chip prototypes functioning well.

  16. Extraordinary Tools for Extraordinary Science: The Impact ofSciDAC on Accelerator Science&Technology

    SciTech Connect

    Ryne, Robert D.

    2006-08-10

    Particle accelerators are among the most complex and versatile instruments of scientific exploration. They have enabled remarkable scientific discoveries and important technological advances that span all programs within the DOE Office of Science (DOE/SC). The importance of accelerators to the DOE/SC mission is evident from an examination of the DOE document, ''Facilities for the Future of Science: A Twenty-Year Outlook''. Of the 28 facilities listed, 13 involve accelerators. Thanks to SciDAC, a powerful suite of parallel simulation tools has been developed that represent a paradigm shift in computational accelerator science. Simulations that used to take weeks or more now take hours, and simulations that were once thought impossible are now performed routinely. These codes have been applied to many important projects of DOE/SC including existing facilities (the Tevatron complex, the Relativistic Heavy Ion Collider), facilities under construction (the Large Hadron Collider, the Spallation Neutron Source, the Linac Coherent Light Source), and to future facilities (the International Linear Collider, the Rare Isotope Accelerator). The new codes have also been used to explore innovative approaches to charged particle acceleration. These approaches, based on the extremely intense fields that can be present in lasers and plasmas, may one day provide a path to the outermost reaches of the energy frontier. Furthermore, they could lead to compact, high-gradient accelerators that would have huge consequences for US science and technology, industry, and medicine. In this talk I will describe the new accelerator modeling capabilities developed under SciDAC, the essential role of multi-disciplinary collaboration with applied mathematicians, computer scientists, and other IT experts in developing these capabilities, and provide examples of how the codes have been used to support DOE/SC accelerator projects.

  17. Measurement of the nu(mu)-CCQE cross-section in the SciBooNE experiment

    SciTech Connect

    Alcaraz-Aunion, Jose Luis; Walding, Joseph; /Imperial Coll., London

    2009-09-01

    SciBooNE is a neutrino and anti-neutrino cross-section experiment at Fermilab, USA. The SciBooNE experiment is summarized and two independent CCQE analyses are described. For one of the analyses, an absolute {nu}{sub {mu}}-CCQE cross section in the neutrino energy region (0.6-1.6) GeV is shown and the technique developed for such a purpose is also explained. The total cross section measured over this energy range agrees well with expectations, based on the NEUT event generator and using a value of 1.21 GeV for the CCQE axial mass.

  18. SciNOvA: A Measurement of Neutrino-Nucleus Scattering in a Narrow-Band Beam

    SciTech Connect

    Paley, J.; Djurcic, Z.; Harris, D.; Tesarek, R.; Feldman, G.; Corwin, L.; Messier, M.D.; Mayer, N.; Musser, J.; Paley, J.; Tayloe, R.; /Indiana U. /Iowa State U. /Minnesota U. /South Carolina U. /Wichita State U. /William-Mary Coll.

    2010-10-15

    We propose to construct and deploy a fine-grained detector in the Fermilab NOvA 2 GeV narrow-band neutrino beam. In this beam, the detector can make unique contributions to the measurement of quasi-elastic scattering, neutral-current elastic scattering, neutral-current {pi}{sup 0} production, and enhance the NOvA measurements of electron neutrino appearance. To minimize cost and risks, the proposed detector is a copy of the SciBar detector originally built for the K2K long baseline experiment and used recently in the SciBooNE experiment.

  19. A Novel Approach for Effectively Treating SCI Pain, Improving Opioid Efficacy, and Preventing Opioid-Induced Constipation: Key Role of Toll-Like Receptor 4 (TLR4)

    DTIC Science & Technology

    2014-10-01

    Approved for Public Release; Distribution Unlimited 13. SUPPLEMENTARY NOTES 14. ABSTRACT Spinal cord injury (SCI) is a disabling and costly condition... Spinal cord injury (SCI) is a disabling and costly condition affecting wounded military personnel (1). SCI is also one of the leading causes of...of life for service-members, veterans, caretakers, and the general population. Keywords Spinal cord injury, central neuropathic pain, rat

  20. Measuring stigma after spinal cord injury: Development and psychometric characteristics of the SCI-QOL Stigma item bank and short form

    PubMed Central

    Kisala, Pamela A.; Tulsky, David S.; Pace, Natalie; Victorson, David; Choi, Seung W.; Heinemann, Allen W.

    2015-01-01

    Objective To develop a calibrated item bank and computer adaptive test (CAT) to assess the effects of stigma on health-related quality of life in individuals with spinal cord injury (SCI). Design Grounded-theory based qualitative item development methods, large-scale item calibration field testing, confirmatory factor analysis, and item response theory (IRT)-based psychometric analyses. Setting Five SCI Model System centers and one Department of Veterans Affairs medical center in the United States. Participants Adults with traumatic SCI. Main Outcome Measures SCI-QOL Stigma Item Bank Results A sample of 611 individuals with traumatic SCI completed 30 items assessing SCI-related stigma. After 7 items were iteratively removed, factor analyses confirmed a unidimensional pool of items. Graded Response Model IRT analyses were used to estimate slopes and thresholds for the final 23 items. Conclusions The SCI-QOL Stigma item bank is unique not only in the assessment of SCI-related stigma but also in the inclusion of individuals with SCI in all phases of its development. Use of confirmatory factor analytic and IRT methods provide flexibility and precision of measurement. The item bank may be administered as a CAT or as a 10-item fixed-length short form and can be used for research and clinical applications. PMID:26010973

  1. Therapeutic effects of anti-spastic medication on neuromuscular abnormalities in SCI: a system identification approach.

    PubMed

    Mirbagheri, M M; Kindig, M; Niu, X; Varoqui, D

    2013-01-01

    Previous attempts to investigate the effects of antispastic medications are limited to clinical studies using that use clinical evaluations to assess. Since these measures are neither objective nor quantitative, the therapeutic effects of such medications on neuromuscular properties have not been fully evaluated. In this study, as a first attempt, we examined the effect of tizanidine, an anti-spastic medication, on modification of the neuromuscular properties of patients with chronic incomplete spinal cord injury (SCI). Each patient was administered 2 mg of tizanidine four times per day for four weeks. The spastic ankle of each patient was evaluated at baseline (prior to any medication, and then 1, 2, and 4 weeks after the start of medication. The ankle was perturbed with a small-amplitude Pseudo-Random Binary Sequence (PRBS) perturbation at various positions over the ankle range-of-motion. A parallel-cascade system identification technique, which provides an objective and quantitative measure of neuromuscular properties, was used to calculate the intrinsic and reflex stiffness. The stiffness vs. joint angle trends were then calculated for each evaluation; these curves were compared across the intervention time to determine the recovery pattern (i.e. change over time) due to the tizanidine intervention. All patients exhibited decreases in reflex stiffness (which abnormally increase after SCI) due to the medication; however, patients were observed to exhibit multiple recovery patterns. For some patients, the reflex stiffness continuously reduced over the four-week intervention period, while for other patients, the decrease during the first week (i.e. between the baseline and 1-Week evaluations) was most pronounced. Also, some patients presented a significant decrease with time, while others presented no improvement in the intrinsic stiffness. These findings suggest that tizanidine may be effective in reducing not only reflex stiffness, but also the subject

  2. A preliminary study of intravenous surfactants in paraplegic dogs: polymer therapy in canine clinical SCI.

    PubMed

    Laverty, Peter H; Leskovar, Alenka; Breur, Gert J; Coates, Joan R; Bergman, Robert L; Widmer, William R; Toombs, James P; Shapiro, Scott; Borgens, Richard B

    2004-12-01

    Hydrophilic polymers, both surfactants and triblock polymers, are known to seal defects in cell membranes. In previous experiments using laboratory animals, we have exploited this capability using polyethylene glycol (PEG) to repair spinal axons after severe, standardized spinal cord injury (SCI) in guinea pigs. Similar studies were conducted using a related co-polymer Poloxamer 188 (P 188). Here we carried out initial investigations of an intravenous application of PEG or P 188 (3500 Daltons, 30% w/w in saline; 2 mL/kg I.V. and 2 mL/kg body weight or 300 mL P 188 per kg, respectively) to neurologically complete cases of paraplegia in dogs. Our aim was to first determine if this is a clinically safe procedure in cases of severe naturally occurring SCI in dogs. Secondarily, we wanted to obtain preliminary evidence if this therapy could be of clinical benefit when compared to a larger number of similar, but historical, control cases. Strict entry criteria permitted recruitment of only neurologically complete paraplegic dogs into this study. Animals were treated by a combination of conventional and experimental techniques within approximately 72 h of admission for spinal trauma secondary to acute, explosive disk herniation. Outcome measures consisted of measurements of voluntary ambulation, deep and superficial pain perception, conscious proprioception in hindlimbs, and evoked potentials (somatosensory evoked potentials [SSEP]). We determined that polymer injection is a safe adjunct to the conventional management of severe neurological injury in dogs. We did not observe any unacceptable clinical response to polymer injection; there were no deaths, nor any other problem arising from, or associated with, the procedures. Outcome measures over the 6-8-week trial were improved by polymer injection when compared to historical cases. This recovery was unexpectedly rapid compared to these comparator groups. The results of this pilot trial provides evidence consistent with the

  3. Observing Some Life Cycles. Teacher's Guide. Unit E3. ZIM-SCI, Zimbabwe Secondary School Science Project.

    ERIC Educational Resources Information Center

    Chitepo, Thoko; And Others

    The Zimbabwe Secondary School Science Project (ZIM-SCI) developed student study guides, corresponding teaching guides, and science kits for a low-cost science course which could be taught during the first 2 years of secondary school without the aid of qualified teachers and conventional laboratories. This teaching guide contains instructional…

  4. Atoms and Molecules. 'O' Level. Teacher's Guide. Unit 2. ZIM-SCI, Zimbabwe Secondary School Science Project. Year 3.

    ERIC Educational Resources Information Center

    Mandizha, George

    The Zimbabwe Secondary School Science Project (ZIM-SCI) developed student study guides, corresponding teaching guides, and science kits for a low-cost science course which could be taught during the third year of secondary school without the aid of qualified teachers and conventional laboratories. This teaching guide, designed to be used in…

  5. Using Electricity. Teacher's Guide. Unit I2. ZIM-SCI, Zimbabwe Secondary School Science Project. Year 2.

    ERIC Educational Resources Information Center

    Chidume, Kwashira

    The Zimbabwe Secondary School Science Project (ZIM-SCI) developed student study guides, corresponding teaching guides, and science kits for a low-cost science course which could be taught during the first 2 years of secondary school without the aid of qualified teachers and conventional laboratories. This teaching guide, designed to be used in…

  6. Understanding Electricity. Teacher's Guide. Unit I1. ZIM-SCI, Zimbabwe Secondary School Science Project. Year 2.

    ERIC Educational Resources Information Center

    Chidume, Kwashira

    The Zimbabwe Secondary School Science Project (ZIM-SCI) developed student study guides, corresponding teaching guides, and science kits for a low-cost science course which could be taught during the first 2 years of secondary school without the aid of qualified teachers and conventional laboratories. This teaching guide, designed to be read in…

  7. Reactions of the rat musculoskeletal system to compressive spinal cord injury (SCI) and whole body vibration (WBV) therapy.

    PubMed

    Schwarz, A; Pick, C; Harrach, R; Stein, G; Bendella, H; Ozsoy, O; Ozsoy, U; Schoenau, E; Jaminet, P; Sarikcioglu, L; Dunlop, S; Angelov, D N

    2015-06-01

    Traumatic spinal cord injury (SCI) causes a loss of locomotor function with associated compromise of the musculo-skeletal system. Whole body vibration (WBV) is a potential therapy following SCI, but little is known about its effects on the musculo-skeletal system. Here, we examined locomotor recovery and the musculo-skeletal system after thoracic (T7-9) compression SCI in adult rats. Daily WBV was started at 1, 7, 14 and 28 days after injury (WBV1-WBV28 respectively) and continued over a 12-week post-injury period. Intact rats, rats with SCI but no WBV (sham-treated) and a group that received passive flexion and extension (PFE) of their hind limbs served as controls. Compared to sham-treated rats, neither WBV nor PFE improved motor function. Only WBV14 and PFE improved body support. In line with earlier studies we failed to detect signs of soleus muscle atrophy (weight, cross sectional diameter, total amount of fibers, mean fiber diameter) or bone loss in the femur (length, weight, bone mineral density). One possible explanation is that, despite of injury extent, the preservation of some axons in the white matter, in combination with quadripedal locomotion, may provide sufficient trophic and neuronal support for the musculoskeletal system.

  8. A Comprehensive Evaluation of H2SO4 formation from OH and sCI pathways in high BVOC environments

    NASA Astrophysics Data System (ADS)

    Kim, S.; Seco, R.; Park, J. H.; Guenther, A. B.; Smith, J. N.; Kuang, C.; Bustillos, J. O. V.; Tota, J.; Souza, R. A. F. D.

    2014-12-01

    The recently highlighted importance of stabilized Criegee intermediates (sCI) as an oxidant for atmospheric SO2 triggered a number of studies to assess the atmospheric implications of H2SO4 formation from the sCI reaction pathway. In addition, it has not been clear why new particle formation events are not observed in the Amazon rain forest. The mostly widely speculated reason has been a very low H2SO4 level. We will present quantitative assessments of SO2 oxidation by sCI leading to the H2SO4 production using a comprehensive observational dataset from a tropical rainforest study during the GOAmazon field campaign at the T3 site in Manacapuru, Amazonas, Brazil. To our best knowledge, this is the first observation of H2SO4 and OH in Amazon and is unique for all tropical sites due to the accompanying comprehensive gas and aerosol observations such as CO, NOX, SO2, VOCs, and physical and chemical characteristics of aerosols. We will discuss observed H2SO4 levels during the GOAmazon field campaigns to demonstrate 1) H2SO4 formation potential from OH and sCI oxidation pathways by contrasting extremely clean and relatively polluted air masses and 2) the Implications of the observed H2SO4 levels in new particle formation and particle growth events.

  9. What Do You Know about Water? Teacher's Guide. Unit D. ZIM-SCI, Zimbabwe Secondary School Science Project.

    ERIC Educational Resources Information Center

    Dube, Peter

    The Zimbabwe Secondary School Science Project (ZIM-SCI) developed student study guides, corresponding teaching guides, and science kits for a low-cost science course which could be taught during the first 2 years of secondary school without the aid of qualified teachers and conventional laboratories. This teaching guide, designed to be read in…

  10. Reactions of the rat musculoskeletal system to compressive spinal cord injury (SCI) and whole body vibration (WBV) therapy

    PubMed Central

    Schwarz, A.; Pick, C.; Harrach, R.; Stein, G.; Bendella, H.; Ozsoy, O.; Ozsoy, U.; Schoenau, E.; Jaminet, P.; Sarikcioglu, L.; Dunlop, S.; Angelov, D.N.

    2015-01-01

    Traumatic spinal cord injury (SCI) causes a loss of locomotor function with associated compromise of the musculo-skeletal system. Whole body vibration (WBV) is a potential therapy following SCI, but little is known about its effects on the musculo-skeletal system. Here, we examined locomotor recovery and the musculo-skeletal system after thoracic (T7-9) compression SCI in adult rats. Daily WBV was started at 1, 7, 14 and 28 days after injury (WBV1-WBV28 respectively) and continued over a 12-week post-injury period. Intact rats, rats with SCI but no WBV (sham-treated) and a group that received passive flexion and extension (PFE) of their hind limbs served as controls. Compared to sham-treated rats, neither WBV nor PFE improved motor function. Only WBV14 and PFE improved body support. In line with earlier studies we failed to detect signs of soleus muscle atrophy (weight, cross sectional diameter, total amount of fibers, mean fiber diameter) or bone loss in the femur (length, weight, bone mineral density). One possible explanation is that, despite of injury extent, the preservation of some axons in the white matter, in combination with quadripedal locomotion, may provide sufficient trophic and neuronal support for the musculoskeletal system. PMID:26032204

  11. Our Planet Earth. Study Guide. Unit F1. ZIM-SCI, Zimbabwe Secondary School Science Project. Year 2.

    ERIC Educational Resources Information Center

    Stocklmayer, Sue

    The Zimbabwe Secondary School Science Project (ZIM-SCI) developed student study guides, corresponding teaching guides, and science kits for a low-cost science course which could be taught during the first 2 years of secondary school without the aid of qualified teachers and conventional laboratories. This teaching guide, designed to be read in…

  12. "Publish SCI Papers or No Degree": Practices of Chinese Doctoral Supervisors in Response to the Publication Pressure on Science Students

    ERIC Educational Resources Information Center

    Li, Yongyan

    2016-01-01

    Publishing English papers in journals listed in Science Citation Index (SCI) has become a requirement for degree conferment for doctoral science students at many universities in China. The publication requirement engenders high pressure for doctoral students and their supervisors and shapes the politics of the relationship between the two parties.…

  13. Life, Beginning and Growing. Teacher's Guide. Unit E1. ZIM-SCI, Zimbabwe Secondary School Science Project.

    ERIC Educational Resources Information Center

    Hosking, Bunty

    The Zimbabwe Secondary School Science Project (ZIM-SCI) developed student study guides, corresponding teaching guides, and science kits for a low-cost science course which could be taught during the first 2 years of secondary school without the aid of qualified teachers and conventional laboratories. This teaching guide, designed to be read in…

  14. Reproducing by Flowers and Seeds. Teacher's Guide. Unit E2. ZIM-SCI, Zimbabwe Secondary School Science Project.

    ERIC Educational Resources Information Center

    Zesaguli, Josie

    The Zimbabwe Secondary School Science Project (ZIM-SCI) developed student study guides, corresponding teaching guides, and science kits for a low-cost science course which could be taught during the first 2 years of secondary school without the aid of qualified teachers and conventional laboratories. This teaching guide, designed to be read in…

  15. Sense from Senses. Teacher's Guide. Unit J. ZIM-SCI, Zimbabwe Secondary School Science Project. Year 2.

    ERIC Educational Resources Information Center

    Simango, Sam

    The Zimbabwe Secondary School Science Project (ZIM-SCI) developed student study guides, corresponding teaching guides, and science kits for a low-cost science course which could be taught during the first 2 years of secondary school without the aid of qualified teachers and conventional laboratories. This teaching guide, designed to be read in…

  16. Living Things and Their Food. Teacher's Guide. Unit G2. ZIM-SCI, Zimbabwe Secondary School Science Project. Year 2.

    ERIC Educational Resources Information Center

    Hosking, Bunty

    The Zimbabwe Secondary School Science Project (ZIM-SCI) developed student study guides, corresponding teaching guides, and science kits for a low-cost science course which could be taught during the first 2 years of secondary school without the aid of qualified teachers and conventional laboratories. This teaching guide, designed to be read in…

  17. Energy for Living. Teacher's Guide. Unit G1. ZIM-SCI, Zimbabwe Secondary School Science Project. Year 2.

    ERIC Educational Resources Information Center

    Hosking, Bunty

    The Zimbabwe Secondary School Science Project (ZIM-SCI) developed student study guides, corresponding teaching guides, and science kits for a low-cost science course which could be taught during the first 2 years of secondary school without the aid of qualified teachers and conventional laboratories. This teaching guide, designed to be read in…

  18. Forces. Teacher's Guide. Units H1 and H2. ZIM-SCI, Zimbabwe Secondary School Science Project. Year 2.

    ERIC Educational Resources Information Center

    Dock, Alan; Hosking, Bunty

    The Zimbabwe Secondary School Science Project (ZIM-SCI) developed student study guides, corresponding teaching guides, and science kits for a low-cost science course which could be taught during the first 2 years of secondary school without the aid of qualified teachers and conventional laboratories. This teaching guide, designed to be read in…

  19. Measurement of the absolute vμ-CCQE cross section at the SciBooNE experiment

    SciTech Connect

    Aunion, Jose Luis Alcaraz

    2010-07-01

    This thesis presents the measurement of the charged current quasi-elastic (CCQE) neutrino-nucleon cross section at neutrino energies around 1 GeV. This measurement has two main physical motivations. On one hand, the neutrino-nucleon interactions at few GeV is a region where existing old data are sparse and with low statistics. The current measurement populates low energy regions with higher statistics and precision than previous experiments. On the other hand, the CCQE interaction is the most useful interaction in neutrino oscillation experiments. The CCQE channel is used to measure the initial and final neutrino fluxes in order to determine the neutrino fraction that disappeared. The neutrino oscillation experiments work at low neutrino energies, so precise measurement of CCQE interactions are essential for flux measurements. The main goal of this thesis is to measure the CCQE absolute neutrino cross section from the SciBooNE data. The SciBar Booster Neutrino Experiment (SciBooNE) is a neutrino and anti-neutrino scattering off experiment. The neutrino energy spectrum works at energies around 1 GeV. SciBooNE was running from June 8th 2007 to August 18th 2008. In that period, the experiment collected a total of 2.65 x 1020 protons on target (POT). This thesis has used full data collection in neutrino mode 0.99 x 1020 POT. A CCQE selection cut has been performed, achieving around 70% pure CCQE sample. A fit method has been exclusively developed to determine the absolute CCQE cross section, presenting results in a neutrino energy range from 0.2 to 2 GeV. The results are compatible with the NEUT predictions. The SciBooNE measurement has been compared with both Carbon (MiniBoonE) and deuterium (ANL and BNL) target experiments, showing a good agreement in both cases.

  20. Bibliometric analysis of the Korean Journal of Parasitology: measured from SCI, PubMed, Scopus, and Synapse databases.

    PubMed

    Lee, Choon Shil

    2009-10-01

    The Korean Journal of Parasitology (KJP) is the official journal of the Korean Society for Parasitology which is celebrating its 50th anniversary in 2009. To assess the contributions and achievements of the KJP, bibliometric analysis was conducted based on the citation data retrieved from 4 major databases; SCI, PubMed, Synapse, and Scopus. It was found that the KJP articles were constantly cited by the articles published in major international journals represented in these databases. More than 60% of 1,370 articles published in the KJP from 1963 to June 2009 were cited at least once by SCI articles. The overall average times cited by SCI articles are 2.6. The rate is almost 3 times higher for the articles published in the last 10 years compared to 1.0 for the articles of the 1960s. The SCI journal impact factor for 2008 is calculated as 0.871. It is increasing and it is expected to increase further with the introduction of the KJP in the database in 2008. The more realistic h-indices were measured from the study data set covering all the citations to the KJP; 17 for SCI, 6 for PubMed, 19 for Synapse, and 17 for Scopus. Synapse extensively picked up the citations to the earlier papers not retrievable from the other 3 databases. It identified many papers published in the 1960s and in the 1980s which have been cited heavily, proving the central role of the KJP in the dissemination of the important research findings over the last 5 decades.

  1. Sci-Fin: Visual Mining Spatial and Temporal Behavior Features from Social Media

    PubMed Central

    Pu, Jiansu; Teng, Zhiyao; Gong, Rui; Wen, Changjiang; Xu, Yang

    2016-01-01

    Check-in records are usually available in social services, which offer us the opportunity to capture and analyze users’ spatial and temporal behaviors. Mining such behavior features is essential to social analysis and business intelligence. However, the complexity and incompleteness of check-in records bring challenges to achieve such a task. Different from the previous work on social behavior analysis, in this paper, we present a visual analytics system, Social Check-in Fingerprinting (Sci-Fin), to facilitate the analysis and visualization of social check-in data. We focus on three major components of user check-in data: location, activity, and profile. Visual fingerprints for location, activity, and profile are designed to intuitively represent the high-dimensional attributes. To visually mine and demonstrate the behavior features, we integrate WorldMapper and Voronoi Treemap into our glyph-like designs. Such visual fingerprint designs offer us the opportunity to summarize the interesting features and patterns from different check-in locations, activities and users (groups). We demonstrate the effectiveness and usability of our system by conducting extensive case studies on real check-in data collected from a popular microblogging service. Interesting findings are reported and discussed at last. PMID:27999398

  2. Impact of SciDAC on accelerator projects across the office of science through electromagnetic modeling

    NASA Astrophysics Data System (ADS)

    Ko, K.; Folwell, N.; Ge, L.; Guetz, A.; Ivanov, V.; Kabel, A.; Kowalski, M.; Lee, L.; Li, Z.; Ng, C.; Prudencio, E.; Schussman, G.; Uplenchwar, R.; Xiao, L.; Collaborators, ISICs/SAPP

    2005-01-01

    Electromagnetic Modelling led by SLAC is a principal component of the "Advanced Computing for 21st Century Accelerator Science and Technology" SciDAC project funded through the Office of High Energy Physics. This large team effort comprises three other national laboratories (LBNL, LLNL, SNL) and six universities (CMU, Columbia, RPI, Stanford, UC Davis and U of Wisconsin) with the goal to develop a set of parallel electromagnetic codes based on unstructured grids to target challenging problems in accelerators, and solve them to unprecedented realism and accuracy. Essential to the code development are the collaborations with the ISICs/SAPP in eigensolvers, meshing, adaptive refinement, shape optimization and visualization (see "Achievements in ISICs/SAPP Collaborations for Electromagnetic Modelling of Accelerators"). Supported by these advances in computational science, we have successfully performed the large-scale simulations that have impacted important accelerator projects across the Office of Science (SC) including the Positron Electron Project (PEP) -II, Next Linear Collider (NLC) and the International Linear Collider (ILC) in High Energy Physics (HEP), the Rare Isotope Accelerator (RIA) in Nuclear Physics (NP) and the Linac Coherent Light Source (LCLS) in Basic Energy Science (BES).

  3. Measurement of neutrino induced charged current neutral pion production cross section at SciBooNE

    SciTech Connect

    Catala-Perez, Juan

    2014-01-01

    SciBooNE is a neutrino scattering experiment located in the Booster Neutrino Beam at Fermilab. It collected data from June 2007 to August 2008 to accurately measure muon neutrino and anti-neutrino cross sections on carbon around 1 GeV neutrino energy. In this thesis we present the results on the measurement of the muon neutrino cross section resulting in a μ- plus a single π0 final state (CC- π0 channel). The present work will show the steps taken to achieve this result: from the reconstruction improvements to the background extraction. The flux-averaged CC - π0 production cross section measurement obtained in this thesis < σCC- π0 > Φ = (5.6 ± 1.9fit ± 0.7beam ± 0.5int - 0.7det) × 10-40 cm2/N at an average energy of 0.89 GeV is found to agree well both with the expectation from the Monte Ca

  4. Sci-Fin: Visual Mining Spatial and Temporal Behavior Features from Social Media.

    PubMed

    Pu, Jiansu; Teng, Zhiyao; Gong, Rui; Wen, Changjiang; Xu, Yang

    2016-12-20

    Check-in records are usually available in social services, which offer us the opportunity to capture and analyze users' spatial and temporal behaviors. Mining such behavior features is essential to social analysis and business intelligence. However, the complexity and incompleteness of check-in records bring challenges to achieve such a task. Different from the previous work on social behavior analysis, in this paper, we present a visual analytics system, Social Check-in Fingerprinting (Sci-Fin), to facilitate the analysis and visualization of social check-in data. We focus on three major components of user check-in data: location, activity, and profile. Visual fingerprints for location, activity, and profile are designed to intuitively represent the high-dimensional attributes. To visually mine and demonstrate the behavior features, we integrate WorldMapper and Voronoi Treemap into our glyph-like designs. Such visual fingerprint designs offer us the opportunity to summarize the interesting features and patterns from different check-in locations, activities and users (groups). We demonstrate the effectiveness and usability of our system by conducting extensive case studies on real check-in data collected from a popular microblogging service. Interesting findings are reported and discussed at last.

  5. Assessing ComSciCon 2013: A science communication workshop for STEM graduate students (Invited)

    NASA Astrophysics Data System (ADS)

    Kohler, S.; Ranjan, S.; Sanders, N.; Morey, S.

    2013-12-01

    We report on the efficacy of Communicating Science 2013, a science communication workshop for graduate students. Effective science communication is imperative for the sharing of scientific ideas, continued funding and support from policy makers, and education of the public. Science graduate students are a prime group to target for communication training, as they will be our future scientists, educators, and EPO professionals. To this end, Communicating Science 2013 (ComSciCon), a workshop organized by and for STEM graduate students, was held in June of this year. This workshop taught graduate students from around the nation to effectively communicate science to both their peers and the public. To learn about grad students' attitudes toward science communication and establish the workshop's efficacy, we surveyed the participants both before and after the workshop. This assessment probed topics such as communication preparation the participants have already received, how science communication is perceived in their home department, and what participants gained from the workshop. We report the results here.

  6. What Is Required In Uganda? The 2007 Report Of The Japan Sci-edu. Support Project

    NASA Astrophysics Data System (ADS)

    Uchida, Tatsuhiro

    2010-07-01

    The development of ability for technology and invention is required as self-sustaining growth of science and technology in Asian and African developing countries. Science education that connects to the real world is the required education for the self-sustaining growth. But in fact, it is very common to study for the entrance examination. According to C. Camilla, S. and Sjo/berg, [The Re-emergence of Values in the Science Curriculum. Rotterdam, 2007, Sense Publishers], Ugandan students are the most interested ones in science and technology (I would like to be a scientist, I would like to get a job in technology) in the world. Science education should mortgages future of youth. Especially science education of developing countries should be directly connected to the real world. Because they need a lot of engineers as skilled worker, we implemented physics education that was directly connected with manufacturing by the sci-edu. support project in Uganda. The best results were achieved by contrivance in spite of poverty area. Our education method gave one form of New Science Education in Asia and Africa.

  7. Final Technical Report - SciDAC Cooperative Agreement: Center for Wave Interactions with Magnetohydrodynamics

    SciTech Connect

    Schnack, Dalton D.

    2012-07-01

    Final technical report for research performed by Dr. Thomas G. Jenkins in collaboration with Professor Dalton D. Schnack on SciDAC Cooperative Agreement: Center for Wave Interactions with Magnetohydrodyanics, DE-FC02-06ER54899, for the period of 8/15/06 - 8/14/11. This report centers on the Slow MHD physics campaign work performed by Dr. Jenkins while at UW-Madison and then at Tech-X Corporation. To make progress on the problem of RF induced currents affect magnetic island evolution in toroidal plasmas, a set of research approaches are outlined. Three approaches can be addressed in parallel. These are: (1) Analytically prescribed additional term in Ohm's law to model the effect of localized ECCD current drive; (2) Introduce an additional evolution equation for the Ohm's law source term. Establish a RF source 'box' where information from the RF code couples to the fluid evolution; and (3) Carry out a more rigorous analytic calculation treating the additional RF terms in a closure problem. These approaches rely on the necessity of reinvigorating the computation modeling efforts of resistive and neoclassical tearing modes with present day versions of the numerical tools. For the RF community, the relevant action item is - RF ray tracing codes need to be modified so that general three-dimensional spatial information can be obtained. Further, interface efforts between the two codes require work as well as an assessment as to the numerical stability properties of the procedures to be used.

  8. [Systematic review of studies on quality of life indexed on the SciELO database].

    PubMed

    Landeiro, Graziela Macedo Bastos; Pedrozo, Celine Cristina Raimundo; Gomes, Maria José; Oliveira, Elizabete Regina de Araújo

    2011-10-01

    Interest in the quality of life construct has increased in the same proportion as the output of instruments to measure it. In order to analyze the scientific literature on the subject to provide a reflection on this construct in Brazil, a systematic review of the SciELO database covering the period from January 2001 to December 2006 was conducted. It was divided into 3 phases: the first involving 180 publications, the second 124, and the third 10. Of the 180 publications, 77.4% consisted of production in the last three years, with growth of 32.4% from 2001 to 2006. Of these, 124 were selected for methodological analysis in accordance with the category of the study: 79 (63.9%) instrument application articles; 25 (20.1%) translation, validation, adaptation and construction of a QOL instrument; 10 (8%) qualitative studies on QOL; 5 (4%) bibliographical review, 5 (4%) on the quality of life concept. The next stage involved the use of questionnaires and/or interview scripts in order to obtain a broader consensus on perceived quality of life from the interviewees. It was seen that there was significant scientific output in the period under scrutiny, with diversification of approaches and methodologies, highlighting the complexity of the quality of life construct.

  9. Lambda Station: Alternate network path forwarding for production SciDAC applications

    SciTech Connect

    Grigoriev, Maxim; Bobyshev, Andrey; Crawford, Matt; DeMar, Phil; Grigaliunas, Vyto; Moibenko, Alexander; Petravick, Don; Newman, Harvey; Steenberg, Conrad; Thomas, Michael; /Caltech

    2007-09-01

    The LHC era will start very soon, creating immense data volumes capable of demanding allocation of an entire network circuit for task-driven applications. Circuit-based alternate network paths are one solution to meeting the LHC high bandwidth network requirements. The Lambda Station project is aimed at addressing growing requirements for dynamic allocation of alternate network paths. Lambda Station facilitates the rerouting of designated traffic through site LAN infrastructure onto so-called 'high-impact' wide-area networks. The prototype Lambda Station developed with Service Oriented Architecture (SOA) approach in mind will be presented. Lambda Station has been successfully integrated into the production version of the Storage Resource Manager (SRM), and deployed at US CMS Tier1 center at Fermilab, as well as at US-CMS Tier-2 site at Caltech. This paper will discuss experiences using the prototype system with production SciDAC applications for data movement between Fermilab and Caltech. The architecture and design principles of the production version Lambda Station software, currently being implemented as Java based web services, will also be presented in this paper.

  10. Exploration tools for drug discovery and beyond: applying SciFinder to interdisciplinary research.

    PubMed

    Haldeman, Margaret; Vieira, Barbara; Winer, Fred; Knutsen, Lars J S

    2005-06-01

    Chemists have long recognized the value of online databases for surveying the literature of their field. Chemical Abstracts Service (CAS) databases covering almost a century's worth of journal articles and patent documents are among the best known and widely used for searching information on compounds. Today's research presents a new challenge, however, as the boundaries of chemistry and biological sciences overlap increasingly. This trend is especially true in the drug discovery field where published findings relating to both chemical and biological entities and their interactions are examined. CAS has expanded its resources to meet the requirements of the new, interdisciplinary challenges faced by today's researchers. This is evident both in the content of CAS databases, which have been expanded to include more biology-related information, and in the technology of the search tools now available to researchers on their desktop. It is the integration of content and search-and-retrieval technology that enables new insights to be made in the vast body of accumulated information. CAS's SciFinder is a widely used research tool for this purpose.

  11. OptoSci educator kits: an immediate solution to photonics teaching laboratories

    NASA Astrophysics Data System (ADS)

    Walsh, Douglas; Moodie, David; Mauchline, Iain; Johnstone, Walter; Culshaw, Brian

    2003-10-01

    The burgeoning growth of the worldwide photonics and optical communications industry has imposed ever increasing demands on the supply of suitably skilled engineers and scientists who can design, install and operate modern photonics systems. In recognition of this need OptoSci, in collaboration with university academics, has commercially developed a series of hardware based teaching packages in optics, optoelectronics and optical communications. Each educator kit is fully self-contained, including all of the optoelectronic hardware and comprehensive literature support. This saves the academic tutor considerable development time and enables the kits to be immediately installed in the photonics teaching laboratory to support accompanying lecture courses. A fundamental design objective of our educator kits is to provide students with hands-on practical experience of photonics components, instruments and systems and allow them to investigate essential physical principles and key technical issues relevant to their lecture courses. This paper will outline the design philosophy behind the products to meet the desired educational aims, and then examine the specific educational objectives and topics investigated in each educator kit.

  12. Active correction of aperture discontinuities (ACAD) for space telescope pupils: a parametic analysis

    NASA Astrophysics Data System (ADS)

    Mazoyer, Johan; Pueyo, Laurent; Norman, Colin; N'Diaye, Mamadou; Mawet, Dimitri; Soummer, Rémi; Perrin, Marshall; Choquet, Élodie; Carlotti, Alexis

    2015-09-01

    As the performance of coronagraphs improves, the achievable contrast is more and more dependent of the shape of the pupil. The future generation of space and ground based coronagraphic instruments will have to achieve high contrast levels on on-axis and/or segmented telescopes. To correct for the high amplitude aberrations introduced by secondary mirror structures and segmentation of the primary mirror, we explore a two deformable mirror (DM) method. The major difficulty of several DM methods is the non-linear relation linking actuator strokes to the point spread function in the coronagraph focal plane. The Active Compensation of Aperture Discontinuities (ACAD) method is achieving this minimization by solving a non linear differential Monge Ampere equation. Once this open loop method have reached the minimum, a close-loop stroke minimization method can be applied to correct for phase and amplitude aberrations to achieve the ultimate contrast. In this paper, I describe the results of the parametric analysis that that I have undertaken on this method. After recalling the principle of the method, I will described the explored parameter space (deformable mirror set-up, shape of the pupil, bandwidth, coronagraph designs). I will precisely described the way I simulated the Vortex coronagraph for this numerical simulation. Finally I will present the preliminary results of this parametric analysis for space telescope pupils only.

  13. Public Data Set: Erratum: "Multi-point, high-speed passive ion velocity distribution diagnostic on the Pegasus Toroidal Experiment" [Rev. Sci. Instrum. 83, 10D516 (2012)

    SciTech Connect

    Burke, Marcus G.; Fonck, Raymond J.; Bongard, Michael W.; Schlossberg, David J.; Winz, Gregory R.

    2016-07-18

    This data set contains openly-documented, machine readable digital research data corresponding to figures published in M.G. Burke et al., 'Erratum: "Multi-point, high-speed passive ion velocity distribution diagnostic on the Pegasus Toroidal Experiment" [Rev. Sci. Instrum. 83, 10D516 (2012)],' Rev. Sci. Instrum. 87, 079902 (2016).

  14. Towards flash flood disaster prevention: the SciNetNat Haz proposal

    NASA Astrophysics Data System (ADS)

    Konstantinos, Papatheodorou; Elena, Tzanou; Carmen, Maftei; Ozgur, Kirca; Hafzullah, Aksoy

    2015-04-01

    Floods occur with a continuously increasing frequency due to climatic changes and cause serious damage in the wider Black Sea area, endangering human life and property. As societies continuously expand, these phenomena are expected to play an increasingly important role, blocking sustainable development unless properly tackled. Flash flood prevention seems at this point, to be the target of effectively mitigating the potential threat. Since in many cases, there is a cross-border character of the problem, collaborative efforts have to be made involving cooperation between countries. To this end, a variety of problems exist, including the "information gap" related to the unavailability of data and the multitude of methodologies used to assess flood hazard; a fact that renders comparison of hazard assessment results and cross border cooperation ineffective. An effort made within the context of the SciNetNatHaz project, suggests a two step approach to produce reliable the results which can lead to decision making regarding designing preventive measures. The first step aims at defining the flood prone areas on a regional scale, using geomorphometric models and readily available topographic data; thus overcoming the problem of data availability for any region of interest. The second step follows a vulnerability and risk assessment of the flood prone areas of interest and focuses on the calculation of flood parameters on a local scale using hydraulic models. Implementation of the full process is based on Open Source software tools so that it can be implemented with minimal costs by anyone interested. Implementation of the proposed procedure in three different cases in Greece and in Romania shows that it can provide accurate and reliable results to support decision making regarding the design of preventive measures. Keywords: Flash floods, hazard assessment, flood disaster prevention, HEC-RAS, SAGA GIS . Acknowledgements: This work is partially funded by the EU through the

  15. Reactivity of stabilized Criegee intermediates (sCI) from isoprene and monoterpene ozonolysis toward SO2 and organic acids

    NASA Astrophysics Data System (ADS)

    Sipilä, M.; Jokinen, T.; Berndt, T.; Richters, S.; Makkonen, R.; Donahue, N. M.; Mauldin, R. L., III; Kurten, T.; Paasonen, P.; Sarnela, N.; Ehn, M.; Junninen, H.; Rissanen, M. P.; Thornton, J.; Stratmann, F.; Herrmann, H.; Worsnop, D. R.; Kulmala, M.; Kerminen, V.-M.; Petäjä, T.

    2014-01-01

    Oxidation processes in Earth's atmosphere are tightly connected to many environmental and human health issues and are essential drivers for biogeochemistry. Until the recent discovery of the atmospheric relevance of stabilized Criegee intermediates (sCI), atmospheric oxidation processes were thought to be dominated by few main oxidants: ozone, hydroxyl radicals (OH), nitrate radicals and, e.g. over oceans, halogen atoms such as chlorine. Here, we report results from laboratory experiments at 293 K and atmospheric pressure focusing on sCI formation from the ozonolysis of isoprene and the most abundant monoterpenes (α-pinene and limonene), and subsequent reactions of the resulting sCIs with SO2 producing sulphuric acid (H2SO4). The measured sCI yields were (0.15 ± 0.07), (0.27 ± 0.12) and (0.58 ± 0.26) for the ozonolysis of α-pinene, limonene and isoprene, respectively. The ratio between the rate coefficient for the sCI loss (including thermal decomposition and the reaction with water vapour) and the rate coefficient for the reaction of sCI with SO2, k(loss) / k(sCI + SO2), was determined at relative humidities of 10% and 50%. Observed values represent the average reactivity of all sCIs produced from the individual alkene used in the ozonolysis. For the monoterpene derived sCIs, the relative rate coefficients k(loss) / k(sCI + SO2) were in the range (2.0-2.4) × 1012 molecule cm-3 and nearly independent on the relative humidity. This fact points to a minor importance of the sCI + H2O reaction in the case of the sCI arising from α-pinene and limonene. For the isoprene sCIs, however, the ratio k(loss) / k(sCI + SO2) was strongly dependent on the relative humidity. To explore whether sCIs could have a more general role in atmospheric oxidation, we investigated as an example the reactivity of acetone oxide (sCI from the ozonolysis of 2,3-dimethyl-2-butene) toward small organic acids, i.e. formic and acetic acid. Acetone oxide was found to react faster with the

  16. Exploring Earth and the Solar System: Educational Outreach Through NASA's Space Place, SciJinks, and Climate Kids Websites

    NASA Technical Reports Server (NTRS)

    Meneses, Joseph Chistopher

    2012-01-01

    NASA's Space Place team publishes engaging content and creates an effective environment to inspire a young audience to dare mighty things. NASA uses the Space Place, Climate Kids, and SciJinks websites to cultivate interest among elementary-school-aged children in both science and technology. During my summer internship at Jet Propulsion Laboratory I used Adobe Flash and ActionScript 3 to develop content for the Space Place, Climate Kids, and SciJinks sites. In addition, I was involved in the development process for ongoing and new projects during my internship. My involvement allowed me to follow a project from concept to design, implementation, and release. I personally worked on three projects this summer, two of which are currently in deployment. The first is a scrambled letter-tile guessing game titled Solar System Scramble. The second, Butterfrog Mix-Up, is a rotating-tile puzzle game. The third project is a unfinished prototype for a maze game.

  17. [Letters to the editor published in Peruvian biomedical journals indexed in SciELO-Peru 2006-2013].

    PubMed

    Montenegro-Idrogo, Juan José; Mejía-Dolores, Jhon William; Chalco-Huamán, Joel L

    2015-01-01

    This bibliometric study describes the characteristics of letters to the editor published between 2006-2013 in biomedical journals indexed in SciELO-Peru.253 letters (10.3% of total publications) were collected. Most letters (139) were in the Peruvian Journal of Experimental Medicine and Public Health, with marked increase throughout those years. 25% of letters submitted included medical student participation. 14% of authors presented with international affiliations and 27% with endogenous affiliation - common in university journals (Anales de la Facultad de Medicina, Revista Médica Herediana).The usual criteria justifying the publication of letters were: opinion of medical fact or public domain (35.6%) and discussion of results, methodological flaws or interpretation (22.9%). In biomedical journals indexed in SciELO Peru the letters to the editor comprise a percentage of publications that has increased in recent years, with low publication of letters of findings or primary data, compared with opinion or criticism.

  18. Clinical Trial of AC105 (Mg/PEG) for Treatment of Acute Spinal Cord Injury (SCI). Phase 2

    DTIC Science & Technology

    2013-10-01

    505-9. Kwon BK, Roy J, Lee JH, Okon E, Zhang H, Marx JC, Kindy MS. (2009) Magnesium chloride in a polyethylene glycol formulation as a...13. SUPPLEMENTARY NOTES 14. ABSTRACT Acorda Therapeutics, Inc. is developing the polymer formulation of magnesium , known as AC-105...15. SUBJECT TERMS AC-105, Magnesium , Mg, Spinal Cord Injury, SCI 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT 18. NUMBER OF

  19. Development of a Small Molecule P2X7R Antagonist as a Treatment for Acute SCI

    DTIC Science & Technology

    2013-10-01

    microglia in response to SCI, and of the role of P2X7 receptor activation in that process . Indeed, in parallel work using uninjured human brain tissue...distinct glial fates are instructed, and how that process may be manipulated for therapeutic purposes. Thus, on the basis of the injury-associated...autocrine loop for the self -maintenance of glial progenitors, the perturbation of which might dictate progenitor recruitment as either reactive glia or

  20. Development of a Small Molecule P2X7R Antagonist as a Treatment for Acute SCI

    DTIC Science & Technology

    2011-10-01

    evaluated the impact of deletion of connexins (Cx30/Cx43) in astrocytes on post-traumatic ATP release. In vivo bioluminescence imaging showed a...Introduction The proposed studies were based on the observati on that ATP release and activation of P2X7 receptors drives the innate inf lammatory...tissue swelling. Prior studies have shown that excess ive ATP release from peri-traumatic regions contributes to the inflammatory response to SCI by

  1. Development of a Small Molecule P2X7R Antagonist as a Treatment for Acute SCI

    DTIC Science & Technology

    2011-10-01

    impact of deletion of connexins (Cx30/Cx43) in astrocytes on post-traumatic ATP release. In vivo bioluminescence imaging showed a significant reduction...the observation that ATP release and activation of P2X7 receptors drives the innate inflammatory response initiated by spinal cord injury. P2X7R...swelling. Prior studies have shown that excessive ATP release from peri-traumatic regions contributes to the inflammatory response to SCI by

  2. SCI1, the first member of the tissue-specific inhibitors of CDK (TIC) class, is probably connected to the auxin signaling pathway

    PubMed Central

    DePaoli, Henrique; Goldman, Gustavo; Goldman, Maria-Helena

    2012-01-01

    The recent finding of a tissue-specific cell cycle regulator (SCI1) that inhibits cell proliferation/differentiation in the upper pistil points to an unanticipated way of controlling plant morphogenesis. The similarity between the SCI1 RNAi-silenced plants and some auxin-related phenotypes suggested that SCI1 could be involved in the auxin signaling pathway. To address this hypothesis, we analyzed the expression of three auxin-related genes in transgenic plants in which SCI1 was silenced and overexpressed. The results showed that the expression levels of the auxin-related genes largely correlated with the SCI1 expression level. Additionally, we analyzed the Arabidopsis SCI1 upstream regulatory region and found putative cis-acting elements also present in the AtCYCB1;1 AtYUC1, AtYUC2 and AtYUC4 URRs, suggesting a cell cycle- and auxin-related transcriptional regulation. Based on our previous and the current studies, we propose SCI1 as a signal transducer engaging auxin signaling and cell division/differentiation. PMID:22301969

  3. Hydrogen and the First Stars: First Results from the SCI-HI 21-cm all-sky spectrum experiment

    NASA Astrophysics Data System (ADS)

    Voytek, Tabitha; Peterson, Jeffrey; Lopez-Cruz, Omar; Jauregui-Garcia, Jose-Miguel; SCI-HI Experiment Team

    2015-01-01

    The 'Sonda Cosmologica de las Islas para la Deteccion de Hidrogeno Neutro' (SCI-HI) experiment is an all-sky 21-cm brightness temperature spectrum experiment studying the cosmic dawn (z~15-35). The experiment is a collaboration between Carnegie Mellon University (CMU) and Instituto Nacional de Astrofísica, Óptica y Electrónica (INAOE) in Mexico. Initial deployment of the SCI-HI experiment occurred in June 2013 on Guadalupe; a small island about 250 km off of the Pacific coast of Baja California in Mexico. Preliminary measurements from this deployment have placed the first observational constraints on the 21-cm all-sky spectrum around 70 MHz (z~20), see Voytek et al (2014).Neutral Hydrogen (HI) is found throughout the universe in the cold gas that makes up the intergalactic medium (IGM). HI can be observed through the spectral line at 21 cm (1.4 GHz) due to hyperfine structure. Expansion of the universe causes the wavelength of this spectral line to stretch at a rate defined by the redshift z, leading to a signal which can be followed through time.Now the strength of the 21-cm signal in the IGM is dependent only on a small number of variables; the temperature and density of the IGM, the amount of HI in the IGM, the UV energy density in the IGM, and the redshift. This means that 21-cm measurements teach us about the history and structure of the IGM. The SCI-HI experiment focuses on the spatially averaged 21-cm spectrum, looking at the temporal evolution of the IGM during the cosmic dawn before reionization.Although the SCI-HI experiment placed first constraints with preliminary data, this data was limited to a narrow frequency regime around 60-85 MHz. This limitation was caused by instrumental difficulties and the presence of residual radio frequency interference (RFI) in the FM radio band (~88-108 MHz). The SCI-HI experiment is currently undergoing improvements and we plan to have another deployment soon. This deployment would be to Socorro and Clarion, two

  4. Acyl-CoA dehydrogenase 9 (ACAD 9) is the long-chain acyl-CoA dehydrogenase in human embryonic and fetal brain.

    PubMed

    Oey, N A; Ruiter, J P N; Ijlst, L; Attie-Bitach, T; Vekemans, M; Wanders, R J A; Wijburg, F A

    2006-07-21

    We recently reported the expression and activity of several fatty acid oxidation enzymes in human embryonic and fetal tissues including brain and spinal cord. Liver and heart showed expression of both very long-chain acyl-CoA dehydrogenase (VLCAD) and long-chain 3-hydroxyacyl-CoA dehydrogenase (LCHAD) mRNA. However, while mRNA expression of LCHAD could be clearly detected in the retina and spinal cord, expression of VLCAD mRNA was low to undetectable in these tissues. Nevertheless, abundant acyl-CoA dehydrogenase (ACAD) activity was detected with palmitoyl-CoA as substrate in fetal central nervous tissue. These conflicting data suggested the presence of a different long-chain ACAD in human embryonic and fetal brain. In this study, using in situ hybridization as well as enzymatic studies, we identified acyl-CoA dehydrogenase 9 (ACAD 9) as the long-chain ACAD in human embryonic and fetal central nervous tissue. Until now, no clinical signs and symptoms of central nervous system involvement have been reported in VLCAD deficiency. A novel long-chain FAO defect, i.e., ACAD 9 deficiency with only central nervous system involvement, could, if not lethal during intra uterine development, easily escape proper diagnosis, since probably no classical signs and symptoms of FAO deficiency will be observed. Screening for ACAD 9 deficiency in patients with undefined neurological symptoms and/or impairment in neurological development of unknown origin is necessary to establish if ACAD 9 deficiency exists as a separate disease entity.

  5. GENESIS SciFlo: Scientific Knowledge Creation on the Grid Using a Semantically-Enabled Dataflow Execution Environment

    NASA Astrophysics Data System (ADS)

    Wilson, B. D.; Manipon, G.; Tang, B.; Mazzoni, D.; Fetzer, E.; Dobinson, E.; Yunck, T.

    2005-12-01

    The General Earth Science Investigation Suite (GENESIS) project is a NASA-sponsored partnership between the Jet Propulsion Laboratory, academia, and NASA data centers to develop a new suite of Web Services tools to facilitate multi-sensor investigations in Earth System Science. The goal of GENESIS is to enable large-scale, multi-instrument atmospheric science using combined datasets from the AIRS, MODIS, MISR, and GPS sensors. Investigations include cross-comparison of spaceborne climate sensors, cloud spectral analysis, study of upper troposphere-stratosphere water transport, study of the aerosol indirect cloud effect, and global climate model validation. The challenges are to bring together very large datasets, reformat and understand the individual instrument retrievals, co-register or re-grid the retrieved physical parameters, perform computationally-intensive data fusion and data mining operations, and accumulate complex statistics over months to years of data. To meet these challenges, we have developed a Grid computing and dataflow framework, named SciFlo, in which we are deploying a set of versatile and reusable operators for data access, subsetting, registration, mining, fusion, compression, and advanced statistical analysis. SciFlo is a system for Scientific Knowledge Creation on the Grid using a Semantically-Enabled Dataflow Execution Environment. SciFlo leverages Simple Object Access Protocol (SOAP) Web Services and the Grid Computing standards (WS-* & Globus Alliance toolkits), and enables scientists to do multi-instrument Earth Science by assembling reusable Web Services and native executables into a distributed computing flow (tree of operators). The SciFlo client & server engines optimize the execution of such distributed data flows and allow the user to transparently find and use datasets and operators without worrying about the actual location of the Grid resources. The scientist injects a distributed computation into the Grid by simply filling

  6. GENESIS SciFlo: Choreographing Interoperable Web Services on the Grid using a Semantically-Enabled Dataflow Execution Environment

    NASA Astrophysics Data System (ADS)

    Wilson, B. D.; Manipon, G.; Xing, Z.

    2007-12-01

    The General Earth Science Investigation Suite (GENESIS) project is a NASA-sponsored partnership between the Jet Propulsion Laboratory, academia, and NASA data centers to develop a new suite of Web Services tools to facilitate multi-sensor investigations in Earth System Science. The goal of GENESIS is to enable large-scale, multi-instrument atmospheric science using combined datasets from the AIRS, MODIS, MISR, and GPS sensors. Investigations include cross-comparison of spaceborne climate sensors, cloud spectral analysis, study of upper troposphere-stratosphere water transport, study of the aerosol indirect cloud effect, and global climate model validation. The challenges are to bring together very large datasets, reformat and understand the individual instrument retrievals, co-register or re-grid the retrieved physical parameters, perform computationally-intensive data fusion and data mining operations, and accumulate complex statistics over months to years of data. To meet these challenges, we have developed a Grid computing and dataflow framework, named SciFlo, in which we are deploying a set of versatile and reusable operators for data access, subsetting, registration, mining, fusion, compression, and advanced statistical analysis. SciFlo leverages remote Web Services, called via Simple Object Access Protocol (SOAP) or REST (one-line) URLs, and the Grid Computing standards (WS-* & Globus Alliance toolkits), and enables scientists to do multi- instrument Earth Science by assembling reusable Web Services and native executables into a distributed computing flow (tree of operators). The SciFlo client & server engines optimize the execution of such distributed data flows and allow the user to transparently find and use datasets and operators without worrying about the actual location of the Grid resources. In particular, SciFlo exploits the wealth of datasets accessible by OpenGIS Consortium (OGC) Web Mapping Servers & Web Coverage Servers (WMS/WCS), and by Open Data

  7. The Fulldome Curriculum for the Spitz SciDome Digital Planetarium: A New Age for Planetarium Education

    NASA Astrophysics Data System (ADS)

    Bradstreet, David H.; Huggins, S. L.

    2010-01-01

    Astronomy education received a huge boost from the Space Program in the 1960's and early 1970's as evidenced by a large increase in school planetariums built nationwide at that time. But with the waning of manned explorations so also went the push for astronomy in the schools, and many school planetariums are underutilized or not used at all. This poster will discuss and illustrate some of the new Fulldome Curriculum that has been developed specifically for the Spitz SciDome digital planetarium powered by Starry Night. It is now possible to teach astronomical concepts in new and exciting ways and present topics that were extremely difficult to convey to lay audiences in the past. One of the strongest advantages of the SciDome is that, since it uses Starry Night as its astronomical engine, students can create their own astronomical configurations in the computer lab or at home using the PC or Mac version and then simply load them onto the SciDome planetarium system and display them for the class on the dome. Additionally, the instructor can create artificial bodies to pose "What if” scenarios, for example, "What would the Moon look like if it didn't rotate synchronously?", or "What would the analemma look like if the Earth's orbit were circular and not an ellipse?" Topics covered in the series include The Moon, Seasons, Coordinate Systems, Roemer's Method of Measuring the Speed of Light, Analemmas in the Solar System, Precession, Mimas and the Cassini Division, Halley's Comet in 1910, Dog Days, Galactic Distributions of Celestial Bodies, Retrograde Paths of Mars, Mercury's Orbit and the Length of the Mercurian Day, Altitude of the North Celestial Pole, Why Polaris Appears Mostly Stationary, Circumpolar Contellations, Planet Definition, Scale of the Solar System, Stonehenge, The Changing Aspect of Saturn's Appearance and Scorpio's Claws.

  8. Observation of cosmic ray hadrons at the top of the Sierra Negra volcano in Mexico with the SciCRT prototype

    SciTech Connect

    Ortiz, E.; Valdés-Galicia, J. F.; Matsubara, Y.; Nagai, Y.; Hurtado, A.; Musalem, O.; García, R.; Anzorena, M. A.; González, L. X.; Itow, Y.; Sako, T.; Lopez, D.; Sasai, Y.; Munakata, K.; Kato, C.; Kozai, M.; Shibata, S.; Takamaru, H.; Kojima, H.; Watanabe, K.; Tsuchiya, H.; Koi, T.

    2016-02-16

    In this study we report the flux of protons and neutral emission measured at the top of the Sierra Negra volcano at 4600 m.a.s.l. (575 g/cm2), in Eastern Mexico. As an example of the capability of the mini-SciCR as a cosmic ray detector we present the Forbush decrease recorded on March 7, 2012. These data were obtained with a cosmic ray detector prototype called mini-SciCR that was operating from October 2010 to July 2012. Our main aims were to measure the hadronic component flux of the secondary cosmic ray and to show the appropriate performance of all system of the detector. To separate the signals of protons from other charged particles we obtained the energy deposition pattern when they cross the detector using a Monte Carlo simulation, and to separate the signals of neutral emission we used an anticoincidence system between the edge bars and the internal bars of the detector. The mini-SciCR is a prototype of a new cosmic ray detector called SciBar Cosmic Ray Telescope (SciCRT) installed in the same place, which is in the process of calibration. The SciCRT will work mainly as a Solar Neutron and Muon Telescope, it is designed to achieve: (1) larger effective area than the current Solar Neutron Telescope, (2) higher energy resolution to determine the energy spectrum of solar neutrons, (3) lower energy threshold, and (4) higher particle identification ability.

  9. Observation of cosmic ray hadrons at the top of the Sierra Negra volcano in Mexico with the SciCRT prototype

    NASA Astrophysics Data System (ADS)

    Ortiz, E.; Valdés-Galicia, J. F.; Matsubara, Y.; Nagai, Y.; Hurtado, A.; Musalem, O.; García, R.; Anzorena, M. A.; González, L. X.; Itow, Y.; Sako, T.; Lopez, D.; Sasai, Y.; Munakata, K.; Kato, C.; Kozai, M.; Shibata, S.; Takamaru, H.; Kojima, H.; Watanabe, K.; Tsuchiya, H.; Koi, T.

    2016-11-01

    In this work we report the flux of protons and neutral emission measured at the top of the Sierra Negra volcano at 4600 m.a.s.l. (575 g/cm2), in Eastern Mexico. As an example of the capability of the mini-SciCR as a cosmic ray detector we present the Forbush decrease recorded on March 7, 2012. These data were obtained with a cosmic ray detector prototype called mini-SciCR that was operating from October 2010 to July 2012. Our main aims were to measure the hadronic component flux of the secondary cosmic ray and to show the appropriate performance of all system of the detector. To separate the signals of protons from other charged particles we obtained the energy deposition pattern when they cross the detector using a Monte Carlo simulation, and to separate the signals of neutral emission we used an anticoincidence system between the edge bars and the internal bars of the detector. The mini-SciCR is a prototype of a new cosmic ray detector called SciBar Cosmic Ray Telescope (SciCRT) installed in the same place, which is in the process of calibration. The SciCRT will work mainly as a Solar Neutron and Muon Telescope, it is designed to achieve: (1) larger effective area than the current Solar Neutron Telescope, (2) higher energy resolution to determine the energy spectrum of solar neutrons, (3) lower energy threshold, and (4) higher particle identification ability.

  10. DOE's SciDAC Visualization and Analytics Center for EnablingTechnologies -- Strategy for Petascale Visual Data Analysis Success

    SciTech Connect

    Bethel, E Wes; Johnson, Chris; Aragon, Cecilia; Rubel, Oliver; Weber, Gunther; Pascucci, Valerio; Childs, Hank; Bremer, Peer-Timo; Whitlock, Brad; Ahern, Sean; Meredith, Jeremey; Ostrouchov, George; Joy, Ken; Hamann, Bernd; Garth, Christoph; Cole, Martin; Hansen, Charles; Parker, Steven; Sanderson, Allen; Silva, Claudio; Tricoche, Xavier

    2007-10-01

    The focus of this article is on how one group of researchersthe DOE SciDAC Visualization and Analytics Center for EnablingTechnologies (VACET) is tackling the daunting task of enabling knowledgediscovery through visualization and analytics on some of the world slargest and most complex datasets and on some of the world's largestcomputational platforms. As a Center for Enabling Technology, VACET smission is the creation of usable, production-quality visualization andknowledge discovery software infrastructure that runs on large, parallelcomputer systems at DOE's Open Computing facilities and that providessolutions to challenging visual data exploration and knowledge discoveryneeds of modern science, particularly the DOE sciencecommunity.

  11. The effect of complex rehabilitation training for 12 weeks on trunk muscle function and spine deformation of patients with SCI.

    PubMed

    Sung, Dong-Hun; Yoon, Seong-Deok; Park, Gi Duck

    2015-03-01

    [Purpose] It is important for patients with incomplete spinal cord injury (SCI) to strengthen their muscle strength and return to the work force one of the ultimate objectives of rehabilitation. This study reports how a single patient with SCI became stabilized in terms of abdominal muscles and back extension muscles, as well as returning the back to the neutral position from spinal deformation, as result of complex exercises performed for 12 weeks. [Subjects] The degree of damage of the subject was rated as C grade. The subject of this study had unstable posture due to paralysis in the lower extremities of the left side after removal of a malignant tumor by surgical operation, and tilting and torsion in the pelvis increased followed by increase of kyphosis in the thoracolumbar spine. The subject was more than two years since diagnosis of incomplete SCI after surgery. [Methods] Using isokinetic lumbar muscle strength measurement equipment, peak torque/weight, total work and average power in flexion and extension of the lumbar region were measured. A trunk measurement system (Formetric 4D, DIERS, Germany), which is a 3D image processing apparatus with high resolution for vertebrae, was used in order to measure 3D vertebrae and pelvis deformation as well as static balance abilities. As an exercise method, a foam roller was used to conduct fascia relaxation massage for warming-up, and postural kyphosis was changed into postural lordosis by lat pull-down using equipment, performed in 5 sets of 15 times preset at 60% intensity of 1RM 4 set of 10 crunch exercises per set using Togu's were done while sitting at the end of Balance pad, and 4 sets of 15 bridge exercises. [Results] All angular speed tests showed a gradual increase in muscle strength. Flexion and extension showed 10% and 3% improvements, respectively. The spine deformation test showed that isokinetic exercise and lat pull-down exercise for 12 weeks resulted in improved spinal shape. [Conclusion] In this study

  12. Development of a Small Molecule P2X7R Antagonist as a Treatment for Acute SCI

    DTIC Science & Technology

    2012-10-01

    brain edema. Methods Mice. Aqp4−/− mice were generated by GenOway by cloning and sequencing of a targeted region of the murine Aqp4 gene in a 129/Sv... genetic back- ground. The strategy was to design a targeted locus allowing us to delete exons 1–3 to avoid any expression of putative splice variants...was made on the back region and a laminectomy was performed aseptically at the T11-T12 level. Before SCI, a catheter was placed in the left femoral

  13. DOE SciDAC's Earth System Grid Center for Enabling Technologies Final Report

    SciTech Connect

    Williams, Dean N.

    2011-09-27

    report at the end of project funding. To continue to serve the climate-science community, we are currently seeking additional funding. Such funding would allow us to maintain and enhance ESGF production and operation of this vital endeavor of cataloging, serving, and analyzing ultra-scale climate science data. At this time, the entire ESG-CET team would like to take this opportunity to sincerely thank our funding agencies in the DOE Scientific Discovery through Advanced Computing (SciDAC) program and the Office of Biological and Environmental Research (OBER) - as well as our national and international collaborators, stakeholders, and partners - for allowing us to work with you and serve the community these past several years.

  14. AACR, ISBD(S) and ISSN: A Comment

    ERIC Educational Resources Information Center

    Fasana, Paul

    1975-01-01

    The recommendation to abandon AACR 6 (Anglo-American Cataloging Rules) should be rejected because of the adverse impact it will have on the quality, integrity, and continuity of existing library catalogs and library collections. (Author)

  15. Challenges of animal models in SCI research: Effects of pre-injury task-specific training in adult rats before lesion.

    PubMed

    May, Zacnicte; Fouad, Karim; Shum-Siu, Alice; Magnuson, David S K

    2015-09-15

    A rarely explored subject in animal research is the effect of pre-injury variables on behavioral outcome post-SCI. Low reporting of such variables may underlie some discrepancies in findings between laboratories. Particularly, intensive task-specific training before a SCI might be important, considering that sports injuries are one of the leading causes of SCI. Thus, individuals with SCI often underwent rigorous training before their injuries. In the present study, we asked whether training before SCI on a grasping task or a swimming task would influence motor recovery in rats. Swim pre-training impaired recovery of swimming 2 and 4 weeks post-injury. This result fits with the idea of motor learning interference, which posits that learning something new may disrupt learning of a new task; in this case, learning strategies to compensate for functional loss after SCI. In contrast to swimming, grasp pre-training did not influence grasping ability after SCI at any time point. However, grasp pre-trained rats attempted to grasp more times than untrained rats in the first 4 weeks post-injury. Also, lesion volume of grasp pre-trained rats was greater than that of untrained rats, a finding which may be related to stress or activity. The increased participation in rehabilitative training of the pre-trained rats in the early weeks post-injury may have potentiated spontaneous plasticity in the spinal cord and counteracted the deleterious effect of interference and bigger lesions. Thus, our findings suggest that pre-training plays a significant role in recovery after CNS damage and needs to be carefully controlled for.

  16. Measuring self-esteem after spinal cord injury: Development, validation and psychometric characteristics of the SCI-QOL Self-esteem item bank and short form

    PubMed Central

    Kalpakjian, Claire Z.; Tate, Denise G.; Kisala, Pamela A.; Tulsky, David S.

    2015-01-01

    Objective To describe the development and psychometric properties of the Spinal Cord Injury-Quality of Life (SCI-QOL) Self-esteem item bank. Design Using a mixed-methods design, we developed and tested a self-esteem item bank through the use of focus groups with individuals with SCI and clinicians with expertise in SCI, cognitive interviews, and item-response theory- (IRT) based analytic approaches, including tests of model fit, differential item functioning (DIF) and precision. Setting We tested a pool of 30 items at several medical institutions across the United States, including the University of Michigan, Kessler Foundation, the Rehabilitation Institute of Chicago, the University of Washington, Craig Hospital, and the James J. Peters/Bronx Department of Veterans Affairs hospital. Participants A total of 717 individuals with SCI completed the self-esteem items. Results A unidimensional model was observed (CFI = 0.946; RMSEA = 0.087) and measurement precision was good (theta range between −2.7 and 0.7). Eleven items were flagged for DIF; however, effect sizes were negligible with little practical impact on score estimates. The final calibrated item bank resulted in 23 retained items. Conclusion This study indicates that the SCI-QOL Self-esteem item bank represents a psychometrically robust measurement tool. Short form items are also suggested and computer adaptive tests are available. PMID:26010972

  17. Measuring resilience after spinal cord injury: Development, validation and psychometric characteristics of the SCI-QOL Resilience item bank and short form

    PubMed Central

    Victorson, David; Tulsky, David S.; Kisala, Pamela A.; Kalpakjian, Claire Z.; Weiland, Brian; Choi, Seung W.

    2015-01-01

    Objective To describe the development and psychometric properties of the Spinal Cord Injury - Quality of Life (SCI-QOL) Resilience item bank and short form. Design Using a mixed-methods design, we developed and tested a resilience item bank through the use of focus groups with individuals with SCI and clinicians with expertise in SCI, cognitive interviews, and item-response theory based analytic approaches, including tests of model fit and differential item functioning (DIF). Setting We tested a 32-item pool at several medical institutions across the United States, including the University of Michigan, Kessler Foundation, the Rehabilitation Institute of Chicago, the University of Washington, Craig Hospital and the James J. Peters/Bronx Department of Veterans Affairs medical center. Participants A total of 717 individuals with SCI completed the Resilience items. Results A unidimensional model was observed (CFI = 0.968; RMSEA = 0.074) and measurement precision was good (theta range between −3.1 and 0.9). Ten items were flagged for DIF, however, after examination of effect sizes we found this to be negligible with little practical impact on score estimates. The final calibrated item bank resulted in 21 retained items. Conclusion This study indicates that the SCI-QOL Resilience item bank represents a psychometrically robust measurement tool. Short form items are also suggested and computer adaptive tests are available. PMID:26010971

  18. Measurement of Neutrino-Nucleon Neutral-Current Elastic Scattering Cross-section at SciBooNE

    SciTech Connect

    Takei, Hideyuki

    2009-02-01

    In this thesis, results of neutrino-nucleon neutral current (NC) elastic scattering analysis are presented. Neutrinos interact with other particles only with weak force. Measurement of cross-section for neutrino-nucleon reactions at various neutrino energy are important for the study of nucleon structure. It also provides data to be used for beam flux monitor in neutrino oscillation experiments. The cross-section for neutrino-nucleon NC elastic scattering contains the axial vector form factor GA(Q2) as well as electromagnetic form factors unlike electromagnetic interaction. GA is propotional to strange part of nucleon spin (Δs) in Q2 → 0 limit. Measurement of NC elastic cross-section with smaller Q2 enables us to access Δs. NC elastic cross-sections of neutrino-nucleon and antineutrino-nucleon were measured earlier by E734 experiment at Brookheaven National Laboratory (BNL) in 1987. In this experiment, cross-sections were measured in Q2 > 0.4 GeV2 region. Result from this experiment was the only published data for NC elastic scattering cross-section published before our experiment. SciBooNE is an experiment for the measurement of neutrino-nucleon scattering cross-secitons using Booster Neutrino Beam (BNB) at FNAL. BNB has energy peak at 0.7 GeV. In this energy region, NC elastic scattering, charged current elastic scattering, charged current pion production, and neutral current pion production are the major reaction branches. SciBar, electromagnetic calorimeter, and Muon Range Detector are the detectors for SciBooNE. The SciBar consists of finely segmented scintillators and 14336 channels of PMTs. It has a capability to reconstruct particle track longer than 8 cm and separate proton from muons and pions using energy deposit information. Signal of NC elastic scattering is a single proton track. In vp → vp process, the recoil proton is detected. On the other hand, most of vn → vn is

  19. Toward Sci-φ: A Lightweight Cloud PaaS for Developing Embarrassingly Parallel Applications Based on Jini

    PubMed Central

    2014-01-01

    Embarrassingly parallel problems are characterised by a very small amount of information to be exchanged among the parts they are split in, during their parallel execution. As a consequence they do not require sophisticated, low-latency, high-bandwidth interconnection networks but can be efficiently computed in parallel by exploiting commodity hardware. Basically, this means cheap clusters, networks of workstations and desktops, and Computational Clouds. This computational model can be exploited to compute a quite large range of problems. This paper describes Sci-φ, an almost complete redesign of a previous tool of ours aimed at developing task parallel applications based on Java and Jini that were shown to be an effective and efficient solution in environments like clusters and networks of workstations and desktops. PMID:24701174

  20. Neonatal multiorgan failure due to ACAD9 mutation and complex I deficiency with mitochondrial hyperplasia in liver, cardiac myocytes, skeletal muscle, and renal tubules.

    PubMed

    Leslie, Nancy; Wang, Xinjian; Peng, Yanyan; Valencia, C Alexander; Khuchua, Zaza; Hata, Jessica; Witte, David; Huang, Taosheng; Bove, Kevin E

    2016-03-01

    Complex I deficiency causes Leigh syndrome, fatal infant lactic acidosis, and neonatal cardiomyopathy. Mutations in more than 100 nuclear DNA and mitochondrial DNA genes miscode for complex I subunits or assembly factors. ACAD9 is an acyl-CoA dehydrogenase with a novel function in assembly of complex I; biallelic mutations cause progressive encephalomyopathy, recurrent Reye syndrome, and fatal cardiomyopathy. We describe the first autopsy in fatal neonatal lethal lactic acidosis due to mutations in ACAD9 that reduced complex I activity. We identified mitochondrial hyperplasia in cardiac myocytes, diaphragm muscle, and liver and renal tubules in formalin-fixed, paraffin-embedded tissue using immunohistochemistry for mitochondrial antigens. Whole-exome sequencing revealed compound heterozygous variants in the ACAD9 gene: c.187G>T (p.E63*) and c.941T>C (p.L314P). The nonsense mutation causes late infantile lethality; the missense variant is novel. Autopsy-derived fibroblasts had reduced complex I activity (53% of control) with normal activity in complexes II to IV, similar to reported cases of ACAD9 deficiency.

  1. System Configuration and Operation Plan of Hayabusa2 DCAM3-D Camera System for Scientific Observation During SCI Impact Experiment

    NASA Astrophysics Data System (ADS)

    Ogawa, Kazunori; Shirai, Kei; Sawada, Hirotaka; Arakawa, Masahiko; Honda, Rie; Wada, Koji; Ishibashi, Ko; Iijima, Yu-ichi; Sakatani, Naoya; Nakazawa, Satoru; Hayakawa, Hajime

    2017-03-01

    An artificial impact experiment is scheduled for 2018-2019 in which an impactor will collide with asteroid 162137 Ryugu (1999 JU3) during the asteroid rendezvous phase of the Hayabusa2 spacecraft. The small carry-on impactor (SCI) will shoot a 2-kg projectile at 2 km/s to create a crater 1-10 m in diameter with an expected subsequent ejecta curtain of a 100-m scale on an ideal sandy surface. A miniaturized deployable camera (DCAM3) unit will separate from the spacecraft at about 1 km from impact, and simultaneously conduct optical observations of the experiment. We designed and developed a camera system (DCAM3-D) in the DCAM3, specialized for scientific observations of impact phenomenon, in order to clarify the subsurface structure, construct theories of impact applicable in a microgravity environment, and identify the impact point on the asteroid. The DCAM3-D system consists of a miniaturized camera with a wide-angle and high-focusing performance, high-speed radio communication devices, and control units with large data storage on both the DCAM3 unit and the spacecraft. These components were successfully developed under severe constraints of size, mass and power, and the whole DCAM3-D system has passed all tests verifying functions, performance, and environmental tolerance. Results indicated sufficient potential to conduct the scientific observations during the SCI impact experiment. An operation plan was carefully considered along with the configuration and a time schedule of the impact experiment, and pre-programed into the control unit before the launch. In this paper, we describe details of the system design concept, specifications, and the operating plan of the DCAM3-D system, focusing on the feasibility of scientific observations.

  2. NASA/DOD Aerospace Knowledge Diffusion Research Project. Paper 27: Knowledge diffusion and US government technology policy: Issues and opportunities for sci/tech librarians

    NASA Technical Reports Server (NTRS)

    Pinelli, Thomas E.; Barclay, Rebecca O.; Hannah, Stan; Lawrence, Barbara; Kennedy, John M.

    1992-01-01

    Federal involvement in simulating economic growth through the development and application of technology policy is currently the subject of serious debate. A recession and the recognition that an internationally competitive economy is a prerequisite for the attainment of national goals have fostered a number of technology policy initiatives aimed at improving the economic competitiveness of American industry. This paper suggests that the successful implementation of U.S. technology policy will require the adoption of a knowledge diffusion model, the development of user oriented information products and services, and a more 'activist' approach on the part of sci/tech librarians in the provision of scientific and technical information (STI). These changes will have a dramatic impact on the sci/tech library of the future and the preparation of sci/tech librarians.

  3. NASA/DoD Aerospace Knowledge Diffusion Research Project. XXVII - Knowledge diffusion and U.S. government technology policy: Issues and opportunities for sci/tech librarians

    NASA Technical Reports Server (NTRS)

    Pinelli, Thomas E.; Barclay, Rebecca O.; Hannah, Stan; Lawrence, Barbara; Kennedy, John M.

    1992-01-01

    Federal involvement in stimulating economic growth through the development and application of technology policy is currently the subject of serious debate. A recession and the recognition that an internationally competitive economy is a prerequisite for the attainment of national goals have fostered a number of technology policy initiatives aimed at improving the economic competitiveness of American industry. This paper suggests that the successful implementation of U.S. technology policy will require the adoption of a knowledge diffusion model, the development of user oriented information products and services, and a more 'activist' approach on the part of sci/tech librarians in the provision of scientific and technical information (STI). These changes will have a dramatic impact on the sci/tech library of the future and the preparation of sci/tech librarians.

  4. Observation of cosmic ray hadrons at the top of the Sierra Negra volcano in Mexico with the SciCRT prototype

    DOE PAGES

    Ortiz, E.; Valdés-Galicia, J. F.; Matsubara, Y.; ...

    2016-02-16

    In this study we report the flux of protons and neutral emission measured at the top of the Sierra Negra volcano at 4600 m.a.s.l. (575 g/cm2), in Eastern Mexico. As an example of the capability of the mini-SciCR as a cosmic ray detector we present the Forbush decrease recorded on March 7, 2012. These data were obtained with a cosmic ray detector prototype called mini-SciCR that was operating from October 2010 to July 2012. Our main aims were to measure the hadronic component flux of the secondary cosmic ray and to show the appropriate performance of all system of themore » detector. To separate the signals of protons from other charged particles we obtained the energy deposition pattern when they cross the detector using a Monte Carlo simulation, and to separate the signals of neutral emission we used an anticoincidence system between the edge bars and the internal bars of the detector. The mini-SciCR is a prototype of a new cosmic ray detector called SciBar Cosmic Ray Telescope (SciCRT) installed in the same place, which is in the process of calibration. The SciCRT will work mainly as a Solar Neutron and Muon Telescope, it is designed to achieve: (1) larger effective area than the current Solar Neutron Telescope, (2) higher energy resolution to determine the energy spectrum of solar neutrons, (3) lower energy threshold, and (4) higher particle identification ability.« less

  5. Leg joint power output during progressive resistance FES-LCE cycling in SCI subjects: developing an index of fatigue

    PubMed Central

    Haapala, Stephenie A; Faghri, Pouran D; Adams, Douglas J

    2008-01-01

    Background The purpose of this study was to investigate the biomechanics of the hip, knee and ankle during a progressive resistance cycling protocol in an effort to detect and measure the presence of muscle fatigue. It was hypothesized that knee power output can be used as an indicator of fatigue in order to assess the cycling performance of SCI subjects. Methods Six spinal cord injured subjects (2 incomplete, 4 complete) between the ages of twenty and fifty years old and possessing either a complete or incomplete spinal cord injury at or below the fourth cervical vertebra participated in this study. Kinematic data and pedal forces were recorded during cycling at increasing levels of resistance. Ankle, knee and hip power outputs and resultant pedal force were calculated. Ergometer cadence and muscle stimulation intensity were also recorded. Results The main findings of this study were: (a) ankle and knee power outputs decreased, whereas hip power output increased with increasing resistance, (b) cadence, stimulation intensity and resultant pedal force in that combined order were significant predictors of knee power output and (c) knowing the value of these combined predictors at 10 rpm, an index of fatigue can be developed, quantitatively expressing the power capacity of the knee joint with respect to a baseline power level defined as fatigue. Conclusion An index of fatigue was successfully developed, proportionalizing knee power capacity during cycling to a predetermined value of fatigue. The fatigue index value at 0/8th kp, measured 90 seconds into active, unassisted pedaling was 1.6. This indicates initial power capacity at the knee to be 1.6 times greater than fatigue. The fatigue index decreased to 1.1 at 2/8th kp, representing approximately a 30% decrease in the knee's power capacity within a 4 minute timespan. These findings suggest that the present cycling protocol is not sufficient for a rider to gain the benefits of FES and thus raises speculation as to

  6. Measurement of K+ production cross section by 8 GeV protons using high-energy neutrino interactions in the SciBooNE detector

    NASA Astrophysics Data System (ADS)

    Cheng, G.; Mariani, C.; Alcaraz-Aunion, J. L.; Brice, S. J.; Bugel, L.; Catala-Perez, J.; Conrad, J. M.; Djurcic, Z.; Dore, U.; Finley, D. A.; Franke, A. J.; Giganti, C.; Gomez-Cadenas, J. J.; Guzowski, P.; Hanson, A.; Hayato, Y.; Hiraide, K.; Jover-Manas, G.; Karagiorgi, G.; Katori, T.; Kobayashi, Y. K.; Kobilarcik, T.; Kubo, H.; Kurimoto, Y.; Louis, W. C.; Loverre, P. F.; Ludovici, L.; Mahn, K. B. M.; Masuike, S.; Matsuoka, K.; McGary, V. T.; Metcalf, W.; Mills, G. B.; Mitsuka, G.; Miyachi, Y.; Mizugashira, S.; Moore, C. D.; Nakajima, Y.; Nakaya, T.; Napora, R.; Nienaber, P.; Orme, D.; Otani, M.; Russell, A. D.; Sanchez, F.; Shaevitz, M. H.; Shibata, T.-A.; Sorel, M.; Stefanski, R. J.; Takei, H.; Tanaka, H.-K.; Tanaka, M.; Tayloe, R.; Taylor, I. J.; Tesarek, R. J.; Uchida, Y.; van de Water, R.; Walding, J. J.; Wascko, M. O.; White, H. B.; Yokoyama, M.; Zeller, G. P.; Zimmerman, E. D.

    2011-07-01

    The SciBooNE Collaboration reports K+ production cross section and rate measurements using high-energy daughter muon neutrino scattering data off the SciBar polystyrene (C8H8) target in the SciBooNE detector. The K+ mesons are produced by 8 GeV protons striking a beryllium target in Fermilab Booster Neutrino Beam line (BNB). Using observed neutrino and antineutrino events in SciBooNE, we measure (d2σ)/(dpdΩ)=(5.34±0.76)mb/(GeV/c×sr) for p+Be→K++X at mean K+ energy of 3.9 GeV and angle (with respect to the proton beam direction) of 3.7 degrees, corresponding to the selected K+ sample. Compared to Monte Carlo predictions using previous higher energy K+ production measurements, this measurement, which uses the NUANCE neutrino interaction generator, is consistent with a normalization factor of 0.85±0.12. This agreement is evidence that the extrapolation of the higher energy K+ measurements to an 8 GeV beam energy using Feynman scaling is valid. This measurement reduces the error on the K+ production cross section from 40% to 14%.

  7. The NASA SCI Files[TM]: The Case of the Shaky Quake. A Lesson Guide with Activities in Mathematics, Science, and Technology.

    ERIC Educational Resources Information Center

    Ricles, Shannon

    The NASA SCI Files is a series of instructional programs consisting of broadcast, print, and online elements emphasizing standards-based instruction, problem-based learning, and science as inquiry. The series seeks to motivate students in grades 3-5 to become critical thinkers and active problem solvers. In this program, the tree house detectives…

  8. The Case of the Physical Fitness Challenge: An Educator Guide with Activities in Mathematics, Science, and Technology. The NASA SCI Files. EG-2005-10-09-LARC

    ERIC Educational Resources Information Center

    Ricles, Shannon; Jaramillo, Becky; Fargo, Michelle

    2005-01-01

    In this companion to the "NASA SCI Files[TM]" episode "The Case of the Physical Fitness Challenge," the tree house detectives learn about anatomy, fitness and nutrition in preparation for the President's Challenge. The guide is divided into four segments aimed at grades 3-5, each of which includes an overview, a set of objectives, vocabulary to be…

  9. The NASA SCI Files[TM]: The Case of the Powerful Pulleys. A Lesson Guide with Activities in Mathematics, Science, and Technology.

    ERIC Educational Resources Information Center

    Ricles, Shannon

    This teacher's guide, with accompanying videotape, presents an episode of the NASA SCI Files. In this episode, one of the tree house detectives has had an accident and cannot get into the tree house. Using problem-based learning, the rest of the gang investigates the world of simple machines and physical science and "pull" together to…

  10. The Case of the Great Space Exploration: An Educator Guide with Activities in Mathematics, Science, and Technology. The NASA SCI Files. EG-2004-09-12-LARC

    ERIC Educational Resources Information Center

    Ricles, Shannon; Jaramillo, Becky; Fargo, Michelle

    2004-01-01

    In this companion to the "NASA SCI Files" episode "The Case of the Great Space Exploration," the tree house detectives learn about NASA's new vision for exploring space. In four segments aimed at grades 3-5, students learn about a variety of aspects of space exploration. Each segment of the guide includes an overview, a set of objectives,…

  11. Measurement of K+ production cross section by 8 GeV protons using high energy neutrino interactions in the SciBooNE detector

    DOE PAGES

    Cheng, G.

    2011-07-28

    The SciBooNE Collaboration reports K+ production cross section and rate measurements using high energy daughter muon neutrino scattering data off the SciBar polystyrene (C8H8) target in the SciBooNE detector. The K+ mesons are produced by 8 GeV protons striking a beryllium target in Fermilab Booster Neutrino Beam line (BNB). Using observed neutrino and antineutrino events in SciBooNE, we measure d2σ/dpdΩ = (5.34 ±0.76) mb/(GeV/c x sr) for p + Be =K+ + X at mean K+ energy of 3.9 GeV and angle (with respect to the proton beam direction) of 3.7 degrees, corresponding to the selected K+ sample. Compared tomore » Monte Carlo predictions using previous higher energy K+ production measurements, this measurement, which uses the NUANCE neutrino interaction generator, is consistent with a normalization factor of 0.85 ± 0.12. This agreement is evidence that the extrapolation of the higher energy K+ measurements to an 8 GeV beam energy using Feynman scaling is valid. This measurement reduces the error on the K+ production cross section from 40% to 14%.« less

  12. Measurement of K+ production cross section by 8 GeV protons using high energy neutrino interactions in the SciBooNE detector

    SciTech Connect

    Cheng, G.

    2011-07-28

    The SciBooNE Collaboration reports K+ production cross section and rate measurements using high energy daughter muon neutrino scattering data off the SciBar polystyrene (C8H8) target in the SciBooNE detector. The K+ mesons are produced by 8 GeV protons striking a beryllium target in Fermilab Booster Neutrino Beam line (BNB). Using observed neutrino and antineutrino events in SciBooNE, we measure d2σ/dpdΩ = (5.34 ±0.76) mb/(GeV/c x sr) for p + Be =K+ + X at mean K+ energy of 3.9 GeV and angle (with respect to the proton beam direction) of 3.7 degrees, corresponding to the selected K+ sample. Compared to Monte Carlo predictions using previous higher energy K+ production measurements, this measurement, which uses the NUANCE neutrino interaction generator, is consistent with a normalization factor of 0.85 ± 0.12. This agreement is evidence that the extrapolation of the higher energy K+ measurements to an 8 GeV beam energy using Feynman scaling is valid. This measurement reduces the error on the K+ production cross section from 40% to 14%.

  13. "A Ton of Faith in Science!" Nature and Role of Assumptions in, and Ideas about, Science and Epistemology Generated upon Watching a Sci-Fi Film

    ERIC Educational Resources Information Center

    Myers, John Y.; Abd-El-Khalick, Fouad

    2016-01-01

    This study (i) explicates the sorts of ideas about science and the nature of knowing that were generated among participant graduate students who viewed the sci-fi film, "Contact," and (ii) examines the interactions between these ideas and ontic stances with which participants approached viewing the film. Eleven doctoral students of…

  14. Erratum: “Multi-point, high-speed passive ion velocity distribution diagnostic on the Pegasus Toroidal Experiment” [Rev. Sci. Instrum. 83, 10D516 (2012)

    SciTech Connect

    Burke, Marcus G.; Fonck, Raymond J.; Bongard, Michael W.; Schlossberg, David J.; Winz, Gregory R.

    2016-07-18

    This article corrects an error in M.G. Burke et al., 'Multi-point, high-speed passive ion velocity distribution diagnostic on the Pegasus Toroidal Experiment,' Rev. Sci. Instrum. 83, 10D516 (2012) pertaining to ion temperature. The conclusions of this paper are not altered by the revised ion temperature measurements.

  15. Effects of Testosterone and Evoked Resistance Exercise after Spinal Cord Injury (TEREX-SCI): study protocol for a randomised controlled trial

    PubMed Central

    Gorgey, Ashraf S; Khalil, Refka E; Gill, Ranjodh; O'Brien, Laura C; Lavis, Timothy; Castillo, Teodoro; Cifu, David X; Savas, Jeannie; Khan, Rehan; Cardozo, Christopher; Lesnefsky, Edward J; Gater, David R; Adler, Robert A

    2017-01-01

    Introduction Individuals with spinal cord injury (SCI) are at a lifelong risk of obesity and chronic metabolic disorders including insulin resistance and dyslipidemia. Within a few weeks of injury, there is a significant decline in whole body fat-free mass, particularly lower extremity skeletal muscle mass, and subsequent increase in fat mass (FM). This is accompanied by a decrease in anabolic hormones including testosterone. Testosterone replacement therapy (TRT) has been shown to increase skeletal muscle mass and improve metabolic profile. Additionally, resistance training (RT) has been shown to increase lean mass and reduce metabolic disturbances in SCI and other clinical populations. Methods and analysis 26 individuals with chronic, motor complete SCI between 18 and 50 years old were randomly assigned to a RT+TRT group (n=13) or a TRT group (n=13). 22 participants completed the initial 16-week training phase of the study and 4 participants withdrew. 12 participants of the 22 completed 16 weeks of detraining. The TRT was provided via transdermal testosterone patches (4–6 mg/day). The RT+TRT group had 16 weeks of supervised unilateral progressive RT using surface neuromuscular electrical stimulation with ankle weights. This study will investigate the effects of evoked RT+TRT or TRT alone on body composition (muscle cross-sectional area, visceral adipose tissue, %FM) and metabolic profile (glucose and lipid metabolism) in individuals with motor complete SCI. Findings from this study may help in designing exercise therapies to alleviate the deterioration in body composition after SCI and decrease the incidence of metabolic disorders in this clinical population. Ethics and dissemination The study is currently approved by the McGuire VA Medical Center and Virginia Commonwealth University. All participants read and signed approved consent forms. Results will be submitted to peer-reviewed journals and presented at national and international conferences. Trial

  16. A multimethod research investigation of consumer involvement in Australian health service accreditation programmes: the ACCREDIT-SCI study protocol

    PubMed Central

    Greenfield, David; Hinchcliff, Reece; Moldovan, Max; Mumford, Virginia; Pawsey, Marjorie; Irene Westbrook, Johanna; Braithwaite, Jeffrey

    2012-01-01

    Introduction Health service accreditation programmes are a regulatory mechanism adopted to drive improvements inpatient safety and quality. Research investigating the benefits or limitations, of consumer involvement in accreditation programmes is negligible. To develop our knowledge in this area the ACCREDIT collaboration (Accreditation Collaborative for the Conduct of Research, Evaluation and Designated Investigations through Teamwork) has developed a research plan, known as the ACCREDIT-SCI (Standards of Consumer Involvement) study protocol. Two complementary studies have been designed: one, to examine the effectiveness of a standard for consumer participation and two, to explore how patient experiences vary across a range of settings with differing accreditation results. Methods and design The research setting is the Australian healthcare system, and the two studies focus on three accreditation programmes in the primary, acute and aged care domains. The studies will use multimethods: document analysis; interviews and surveys. Participants will be stakeholders across the three domains including: policy officers; frontline healthcare professionals; accreditation agency personnel, including surveyors and healthcare consumers. Drawing on previous experience, the research team has developed purpose-designed tools. Data will be analysed using thematic, narrative and statistical (descriptive and inferential) procedures. Ethics and dissemination The University of New South Wales Human Research Ethics Committee has approved the two studies (HREC 10274). Findings will be disseminated through seminars, conference presentations, academic publications and research partner websites. The findings will be formulated to facilitate uptake by policy and accreditation agency professionals, researchers and academics, and consumers, nationally and internationally. PMID:23059848

  17. Astrobites and GeoSciBites: Using Online Research Digests for Outreach to Undergraduates and the Broader Community

    NASA Astrophysics Data System (ADS)

    Ranjan, S.; Kohler, S.; Sanders, N.; Morey, S.

    2011-12-01

    Effective science communication is imperative for the sharing of scientific ideas, continued funding and support from policy makers, and education of the public. As future researchers and educators, it is particularly important to engage graduate students in science communication. Astrobites (http://astrobites.org) is an innovative education initiative developed by graduate students in planetary science, astronomy, and astrophysics. Our goal is to help undergraduates make the transition from the classroom to careers in research by introducing them to the astronomical literature in a pedagogical, approachable, and comprehensible way. Every day we select one new journal article posted to the astrophysics preprint server (arXiv.org/astro-ph) and prepare a brief summary describing methods and results, explain jargon, and provide context. We also write regular blog posts containing career advice, such as tips for applying for fellowships or demystifying the publishing process. The articles are written by 30 graduate students in astrophysics from throughout the US and Europe and are read by 1000 daily readers worldwide, including undergraduates, researchers, and interested non-scientists. We describe lessons learned in starting, sustaining, and expanding science outreach blogs like Astrobites. We survey our readership and present analysis summarizing our reader base and impact. We report on the foundation of other ';bites blogs, focusing on the foundation of GeoSciBites, a geophysical sciences outreach blog. We discuss future opportunities for additional outreach initiatives in new disciplines.

  18. Evaluation of university scientific research ability based on the output of sci-tech papers: A D-AHP approach

    PubMed Central

    Wang, Lifang

    2017-01-01

    University scientific research ability is an important indicator to express the strength of universities. In this paper, the evaluation of university scientific research ability is investigated based on the output of sci-tech papers. Four university alliances from North America, UK, Australia, and China, are selected as the case study of the university scientific research evaluation. Data coming from Thomson Reuters InCites are collected to support the evaluation. The work has contributed new framework to the issue of university scientific research ability evaluation. At first, we have established a hierarchical structure to show the factors that impact the evaluation of university scientific research ability. Then, a new MCDM method called D-AHP model is used to implement the evaluation and ranking of different university alliances, in which a data-driven approach is proposed to automatically generate the D numbers preference relations. Next, a sensitivity analysis has been given to show the impact of weights of factors and sub-factors on the evaluation result. At last, the results obtained by using different methods are compared and discussed to verify the effectiveness and reasonability of this study, and some suggestions are given to promote China’s scientific research ability. PMID:28212446

  19. Astrobites and GeoSciBites: Using Online Research Digests for Outreach to Undergraduates and the Broader Community

    NASA Astrophysics Data System (ADS)

    Ranjan, S.; Kohler, S.; Sanders, N.; Morey, S.

    2013-12-01

    Effective science communication is imperative for the sharing of scientific ideas, continued funding and support from policy makers, and education of the public. As future researchers and educators, it is particularly important to engage graduate students in science communication. Astrobites (http://astrobites.org) is an innovative education initiative developed by graduate students in planetary science, astronomy, and astrophysics. Our goal is to help undergraduates make the transition from the classroom to careers in research by introducing them to the astronomical literature in a pedagogical, approachable, and comprehensible way. Every day we select one new journal article posted to the astrophysics preprint server (arXiv.org/astro-ph) and prepare a brief summary describing methods and results, explain jargon, and provide context. We also write regular blog posts containing career advice, such as tips for applying for fellowships or demystifying the publishing process. The articles are written by 30 graduate students in astrophysics from throughout the US and Europe and are read by 1000 daily readers worldwide, including undergraduates, researchers, and interested non-scientists. We describe lessons learned in starting, sustaining, and expanding science outreach blogs like Astrobites. We survey our readership and present analysis summarizing our reader base and impact. We report on the foundation of other ';bites blogs, focusing on the foundation of GeoSciBites, a geophysical sciences outreach blog. We discuss future opportunities for additional outreach initiatives in new disciplines.

  20. Twenty years of Internet-based research at SCiP: A discussion of surviving concepts and new methodologies.

    PubMed

    Wolfe, Christopher R

    2017-02-07

    This discussion of the symposium 20 Years of Internet-Based Research at SCiP: Surviving Concepts, New Methodologies compares the issues faced by the pioneering Internet-based psychology researchers who presented at the first symposia on the topic, at the 1996 annual meeting of the Society for Computers in Psychology, to the issues facing researchers today. New methodologies unavailable in the early days of Web-based psychological research are discussed, with an emphasis on mobile computing with smartphones that is capitalizing on capabilities such as touch screens and gyro sensors. A persistent issue spanning the decades has been the challenge of conducting scientific research with consumer-grade electronics. In the 1996 symposia on Internet-based research, four advantages were identified: easy access to a geographically unlimited subject population, including subjects from very specific and previously inaccessible target populations; bringing the experiment to the subject; high statistical power through large sample size; and reduced cost. In retrospect, it appears that Internet-based research has largely lived up to this early promise-with the possible exception of sample size, since the public demand for controlled psychology experiments has not always been greater than the supply offered by researchers. There are many reasons for optimism about the future of Internet-based research. However, unless courses and textbooks on psychological research methods begin to give Web-based research the attention it deserves, the future of Internet-based psychological research will remain in doubt.

  1. ReSciPE for Scientific Inquiry: Professional Development for Scientists to Support Their Work With Education

    NASA Astrophysics Data System (ADS)

    Smith, L. K.; Laursen, S.; Schott, C.

    2006-12-01

    Funders and institutions are asking scientists to become more involved in communicating the "broader impacts" of their work with the public. Many scientists also wish to contribute to public science literacy and high-quality science education in schools. The ReSciPE Project--Resources for Scientists in Partnership with Education--is providing professional development workshops and other resources to scientists who are involved in education as volunteers or through professional commitments. As of fall 2006, we have presented 16 workshops on "Scientific Inquiry in the K-12 Classroom" to over 350 scientists and science educators at professional meetings, laboratories, and universities from Massachusetts to Hawaii. We will describe the project goals and our model for helping scientists to become more effective in working with students and teachers. Evaluation results from pre- and post-workshop surveys of over 200 workshop participants demonstrate that we are reaching an audience of working scientists as well as science educators and E/PO specialists, that our audience is diverse in gender, ethnicity, and career stage, and that the workshops are effective in broadening participants' ideas of their potential role in education. However, they also have ongoing needs for both knowledge and support. We argue that working with education or other public audiences is an increasingly important professional skill for scientists and offer this project as one experiment in providing appropriate professional development for this work.

  2. Evaluation of university scientific research ability based on the output of sci-tech papers: A D-AHP approach.

    PubMed

    Zong, Fan; Wang, Lifang

    2017-01-01

    University scientific research ability is an important indicator to express the strength of universities. In this paper, the evaluation of university scientific research ability is investigated based on the output of sci-tech papers. Four university alliances from North America, UK, Australia, and China, are selected as the case study of the university scientific research evaluation. Data coming from Thomson Reuters InCites are collected to support the evaluation. The work has contributed new framework to the issue of university scientific research ability evaluation. At first, we have established a hierarchical structure to show the factors that impact the evaluation of university scientific research ability. Then, a new MCDM method called D-AHP model is used to implement the evaluation and ranking of different university alliances, in which a data-driven approach is proposed to automatically generate the D numbers preference relations. Next, a sensitivity analysis has been given to show the impact of weights of factors and sub-factors on the evaluation result. At last, the results obtained by using different methods are compared and discussed to verify the effectiveness and reasonability of this study, and some suggestions are given to promote China's scientific research ability.

  3. The End of Alchemy? The Repudiation and Persistence of Chrysopoeia at the Académie Royale des Sciences in the Eighteenth Century.

    PubMed

    Principe, Lawrence M

    2014-01-01

    The general abandonment of serious endeavor toward metallic transmutation represents a major development in the history of chemistry, yet its exact causes and timing remain unclear. This essay examines the fate of chrysopoeia at the eighteenth-century Académie Royale des Sciences. It reveals a long-standing tension between Académie chemists, who pursued transmutation, and administrators, who tried to suppress it. This tension provides background for Etienne-François Geoffroy's 1722 paper describing fraudulent practices around transmutation. Although transmutation seems to disappear after Geoffroy's paper, manuscripts reveal that most of the institution's chemists continued to pursue it privately until at least the 1760s, long after widely accepted dates for the "demise of alchemy" in learned circles.

  4. Sci-Fi Science.

    ERIC Educational Resources Information Center

    Freudenrich, Craig C.

    2000-01-01

    Recommends using science fiction television episodes, novels, and films for teaching science and motivating students. Studies Newton's Law of Motion, principles of relativity, journey to Mars, interplanetary trajectories, artificial gravity, and Martian geology. Discusses science fiction's ability to capture student interest and the advantages of…

  5. Sci-Vis Framework

    SciTech Connect

    Arthur Bleeker, PNNL

    2015-03-11

    SVF is a full featured OpenGL 3d framework that allows for rapid creation of complex visualizations. The SVF framework handles much of the lifecycle and complex tasks required for a 3d visualization. Unlike a game framework SVF was designed to use fewer resources, work well in a windowed environment, and only render when necessary. The scene also takes advantage of multiple threads to free up the UI thread as much as possible. Shapes (actors) in the scene are created by adding or removing functionality (through support objects) during runtime. This allows a highly flexible and dynamic means of creating highly complex actors without the code complexity (it also helps overcome the lack of multiple inheritance in Java.) All classes are highly customizable and there are abstract classes which are intended to be subclassed to allow a developer to create more complex and highly performant actors. There are multiple demos included in the framework to help the developer get started and shows off nearly all of the functionality. Some simple shapes (actors) are already created for you such as text, bordered text, radial text, text area, complex paths, NURBS paths, cube, disk, grid, plane, geometric shapes, and volumetric area. It also comes with various camera types for viewing that can be dragged, zoomed, and rotated. Picking or selecting items in the scene can be accomplished in various ways depending on your needs (raycasting or color picking.) The framework currently has functionality for tooltips, animation, actor pools, color gradients, 2d physics, text, 1d/2d/3d textures, children, blending, clipping planes, view frustum culling, custom shaders, and custom actor states

  6. Basics of SCI Rehabilitation

    MedlinePlus Videos and Cool Tools

    ... Question Videos by Family Relationship Videos by Experts Resources The Short List Government Programs Family and Caregiver ... by Family Relationship Videos by Spinal Cord Experts Resources Forums Peer Counseling Blog About Us Contact Donate ...

  7. Preclinical Pharmacokinetics and Pharmacodynamic Target of SCY-078, a First-in-Class Orally Active Antifungal Glucan Synthesis Inhibitor, in Murine Models of Disseminated Candidiasis.

    PubMed

    Wring, Stephen A; Randolph, Ryan; Park, SeongHee; Abruzzo, George; Chen, Qing; Flattery, Amy; Garrett, Graig; Peel, Michael; Outcalt, Russell; Powell, Kendall; Trucksis, Michelle; Angulo, David; Borroto-Esoda, Katyna

    2017-04-01

    SCY-078 (MK-3118) is a novel, semisynthetic derivative of enfumafungin and represents the first compound of the triterpene class of antifungals. SCY-078 exhibits potent inhibition of β-(1,3)-d-glucan synthesis, an essential cell wall component of many pathogenic fungi, including Candida spp. and Aspergillus spp. SCY-078 is currently in phase 2 clinical development for the treatment of invasive fungal diseases. In vitro disposition studies to assess solubility, intestinal permeability, and metabolic stability were predictive of good oral bioavailability. Preclinical pharmacokinetic studies were consistent with once-daily administration to humans. After intravenous delivery, plasma clearance in rodents and dogs was low, representing <15% and <25% of hepatic blood flow, respectively. The terminal elimination-phase half-life was 5.5 to 8.7 h in rodents, and it was ∼9.3 h in dogs. The volume of distribution at steady-state was high (4.7 to 5.3 liters/kg), a finding suggestive of extensive tissue distribution. Exposure of SCY-078 in kidney tissue, a target organ for invasive fungal disease such as candidiasis, exceeded plasma by 20- to 25-fold for the area under the concentration-time curve from 0 h to infinity (AUC0-∞) and Cmax SCY-078 achieved efficacy endpoints following oral delivery across multiple murine models of disseminated candidiasis. The pharmacokinetic/pharmacodynamic indices Cmax/MIC and AUC/MIC correlated with outcome. Target therapeutic exposure, expressed as the plasma AUC0-24, was comparable across models, with an upper value of 11.2 μg·h/ml (15.4 μM·h); the corresponding mean value for free drug AUC/MIC was ∼0.75. Overall, these results demonstrate that SCY-078 has the oral and intravenous (i.v.) pharmacokinetic properties and potency in murine infection models of disseminated candidiasis to support further investigation as a novel i.v. and oral treatment for invasive fungal diseases.

  8. Preclinical Pharmacokinetics and Pharmacodynamic Target of SCY-078, a First-in-Class Orally Active Antifungal Glucan Synthesis Inhibitor, in Murine Models of Disseminated Candidiasis

    PubMed Central

    Randolph, Ryan; Park, SeongHee; Abruzzo, George; Chen, Qing; Flattery, Amy; Garrett, Graig; Peel, Michael; Outcalt, Russell; Powell, Kendall; Trucksis, Michelle; Angulo, David; Borroto-Esoda, Katyna

    2017-01-01

    ABSTRACT SCY-078 (MK-3118) is a novel, semisynthetic derivative of enfumafungin and represents the first compound of the triterpene class of antifungals. SCY-078 exhibits potent inhibition of β-(1,3)-d-glucan synthesis, an essential cell wall component of many pathogenic fungi, including Candida spp. and Aspergillus spp. SCY-078 is currently in phase 2 clinical development for the treatment of invasive fungal diseases. In vitro disposition studies to assess solubility, intestinal permeability, and metabolic stability were predictive of good oral bioavailability. Preclinical pharmacokinetic studies were consistent with once-daily administration to humans. After intravenous delivery, plasma clearance in rodents and dogs was low, representing <15% and <25% of hepatic blood flow, respectively. The terminal elimination-phase half-life was 5.5 to 8.7 h in rodents, and it was ∼9.3 h in dogs. The volume of distribution at steady-state was high (4.7 to 5.3 liters/kg), a finding suggestive of extensive tissue distribution. Exposure of SCY-078 in kidney tissue, a target organ for invasive fungal disease such as candidiasis, exceeded plasma by 20- to 25-fold for the area under the concentration-time curve from 0 h to infinity (AUC0–∞) and Cmax. SCY-078 achieved efficacy endpoints following oral delivery across multiple murine models of disseminated candidiasis. The pharmacokinetic/pharmacodynamic indices Cmax/MIC and AUC/MIC correlated with outcome. Target therapeutic exposure, expressed as the plasma AUC0–24, was comparable across models, with an upper value of 11.2 μg·h/ml (15.4 μM·h); the corresponding mean value for free drug AUC/MIC was ∼0.75. Overall, these results demonstrate that SCY-078 has the oral and intravenous (i.v.) pharmacokinetic properties and potency in murine infection models of disseminated candidiasis to support further investigation as a novel i.v. and oral treatment for invasive fungal diseases. PMID:28137806

  9. Ontological Encoding of GeoSciML and INSPIRE geological standard vocabularies and schemas: application to geological mapping

    NASA Astrophysics Data System (ADS)

    Lombardo, Vincenzo; Piana, Fabrizio; Mimmo, Dario; Fubelli, Giandomenico; Giardino, Marco

    2016-04-01

    Encoding of geologic knowledge in formal languages is an ambitious task, aiming at the interoperability and organic representation of geological data, and semantic characterization of geologic maps. Initiatives such as GeoScience Markup Language (last version is GeoSciML 4, 2015[1]) and INSPIRE "Data Specification on Geology" (an operative simplification of GeoSciML, last version is 3.0 rc3, 2013[2]), as well as the recent terminological shepherding of the Geoscience Terminology Working Group (GTWG[3]) have been promoting information exchange of the geologic knowledge. There have also been limited attempts to encode the knowledge in a machine-readable format, especially in the lithology domain (see e.g. the CGI_Lithology ontology[4]), but a comprehensive ontological model that connect the several knowledge sources is still lacking. This presentation concerns the "OntoGeonous" initiative, which aims at encoding the geologic knowledge, as expressed through the standard vocabularies, schemas and data models mentioned above, through a number of interlinked computational ontologies, based on the languages of the Semantic Web and the paradigm of Linked Open Data. The initiative proceeds in parallel with a concrete case study, concerning the setting up of a synthetic digital geological map of the Piemonte region (NW Italy), named "GEOPiemonteMap" (developed by the CNR Institute of Geosciences and Earth Resources, CNR IGG, Torino), where the description and classification of GeologicUnits has been supported by the modeling and implementation of the ontologies. We have devised a tripartite ontological model called OntoGeonous that consists of: 1) an ontology of the geologic features (in particular, GeologicUnit, GeomorphologicFeature, and GeologicStructure[5], modeled from the definitions and UML schemata of CGI vocabularies[6], GeoScienceML and INSPIRE, and aligned with the Planetary realm of NASA SWEET ontology[7]), 2) an ontology of the Earth materials (as defined by the

  10. SciDAC's Earth System Grid Center for Enabling Technologies Semiannual Progress Report October 1, 2010 through March 31, 2011

    SciTech Connect

    Williams, Dean N.

    2011-04-02

    This report summarizes work carried out by the Earth System Grid Center for Enabling Technologies (ESG-CET) from October 1, 2010 through March 31, 2011. It discusses ESG-CET highlights for the reporting period, overall progress, period goals, and collaborations, and lists papers and presentations. To learn more about our project and to find previous reports, please visit the ESG-CET Web sites: http://esg-pcmdi.llnl.gov/ and/or https://wiki.ucar.edu/display/esgcet/Home. This report will be forwarded to managers in the Department of Energy (DOE) Scientific Discovery through Advanced Computing (SciDAC) program and the Office of Biological and Environmental Research (OBER), as well as national and international collaborators and stakeholders (e.g., those involved in the Coupled Model Intercomparison Project, phase 5 (CMIP5) for the Intergovernmental Panel on Climate Change (IPCC) 5th Assessment Report (AR5); the Community Earth System Model (CESM); the Climate Science Computational End Station (CCES); SciDAC II: A Scalable and Extensible Earth System Model for Climate Change Science; the North American Regional Climate Change Assessment Program (NARCCAP); the Atmospheric Radiation Measurement (ARM) program; the National Aeronautics and Space Administration (NASA), the National Oceanic and Atmospheric Administration (NOAA)), and also to researchers working on a variety of other climate model and observation evaluation activities. The ESG-CET executive committee consists of Dean N. Williams, Lawrence Livermore National Laboratory (LLNL); Ian Foster, Argonne National Laboratory (ANL); and Don Middleton, National Center for Atmospheric Research (NCAR). The ESG-CET team is a group of researchers and scientists with diverse domain knowledge, whose home institutions include eight laboratories and two universities: ANL, Los Alamos National Laboratory (LANL), Lawrence Berkeley National Laboratory (LBNL), LLNL, NASA/Jet Propulsion Laboratory (JPL), NCAR, Oak Ridge National

  11. Variations in IBD (ACAD8) in children with elevated C4-carnitine detected by tandem mass spectrometry newborn screening.

    PubMed

    Pedersen, Christina B; Bischoff, Claus; Christensen, Ernst; Simonsen, Henrik; Lund, Allan M; Young, Sarah P; Koeberl, Dwight D; Millington, David S; Roe, Charles R; Roe, Diane S; Wanders, Ronald J A; Ruiter, Jos P N; Keppen, Laura D; Stein, Quinn; Knudsen, Inga; Gregersen, Niels; Andresen, Brage S

    2006-09-01

    The isobutyryl-CoA dehydrogenase (IBD) enzyme is involved in the degradation of valine. IBD deficiency was first reported in 1998 and subsequent genetic investigations identified acyl-CoA dehydrogenase (ACAD) 8, now IBD, as the gene responsible for IBD deficiency. Only three individuals homozygous or compound heterozygous for variations in the IBD gene have been reported. We present IBD deficiency in an additional four newborns with elevated C(4)-carnitine identified by tandem mass spectrometry (MS/MS) screening in Denmark and the United States. Three showed urinary excretions of isobutyryl-glycine, and in vitro probe analysis of fibroblasts from two newborns indicated enzymatic IBD defect. Molecular genetic analysis revealed seven new rare variations in the IBD gene (c.348C>A, c.400G>T, c.409G>A, c.455T>C, c.958G>A, c.1000C>T and c.1154G>A). Furthermore, sequence analysis of the short-chain acyl-CoA dehydrogenase (SCAD) gene revealed heterozygosity for the prevalent c.625G>A susceptibility variation in all newborns and in the first reported IBD patient. Functional studies in isolated mitochondria demonstrated that the IBD variations present in the Danish newborn (c.409G>A and c.958G>A) together with a previously published IBD variation (c.905G>A) disturbed protein folding and reduced the levels of correctly folded IBD tetramers. Accordingly, low/no IBD residual enzyme activity was detectable when the variant IBD proteins were overexpressed in Chang cells.

  12. Results of a Telephone Survey of Television Station Managers Concerning the NASA SCI Files(TM) and NASA CONNECT(TM)

    NASA Technical Reports Server (NTRS)

    Pinelli, Thomas E.; Perry, Jeannine

    2004-01-01

    A telephone survey of television station managers concerning 2 instructional television programs, the NASA SCI Files(TM) and NASA CONNECT(TM), offered by the NASA Langley Center for Distance Learning (CDL) was conducted. Using a 4-point scale, with 4 being very satisfied, survey participants reported that they were either very satisfied (77.1 percent) or satisfied (19.9 percent) with the overall (educational and technical) quality of the NASA SCI Files(TM). Using a 4-point scale, with 4 being very satisfied, survey participants reported that they were either very satisfied (77.9 percent) or satisfied (19.1 percent) with the overall (educational and technical) quality of NASA CONNECT(TM) .

  13. SciDAC's Earth System Grid Center for Enabling Technologies Semi-Annual Progress Report for the Period October 1, 2009 through March 31, 2010

    SciTech Connect

    Williams, Dean N.; Foster, I. T.; Middleton, D. E.; Ananthakrishnan, R.; Siebenlist, F.; Shoshani, A.; Sim, A.; Bell, G.; Drach, R.; Ahrens, J.; Jones, P.; Brown, D.; Chastang, J.; Cinquini, L.; Fox, P.; Harper, D.; Hook, N.; Nienhouse, E.; Strand, G.; West, P.; Wilcox, H.; Wilhelmi, N.; Zednik, S.; Hankin, S.; Schweitzer, R.; Bernholdt, D.; Chen, M.; Miller, R.; Shipman, G.; Wang, F.; Bharathi, S.; Chervenak, A.; Schuler, R.; Su, M.

    2010-04-21

    This report summarizes work carried out by the ESG-CET during the period October 1, 2009 through March 31, 2009. It includes discussion of highlights, overall progress, period goals, collaborations, papers, and presentations. To learn more about our project, and to find previous reports, please visit the Earth System Grid Center for Enabling Technologies (ESG-CET) website. This report will be forwarded to the DOE SciDAC program management, the Office of Biological and Environmental Research (OBER) program management, national and international collaborators and stakeholders (e.g., the Community Climate System Model (CCSM), the Intergovernmental Panel on Climate Change (IPCC) 5th Assessment Report (AR5), the Climate Science Computational End Station (CCES), the SciDAC II: A Scalable and Extensible Earth System Model for Climate Change Science, the North American Regional Climate Change Assessment Program (NARCCAP), and other wide-ranging climate model evaluation activities).

  14. Measuring grief and loss after spinal cord injury: Development, validation and psychometric characteristics of the SCI-QOL Grief and Loss item bank and short form

    PubMed Central

    Kalpakjian, Claire Z.; Tulsky, David S.; Kisala, Pamela A.; Bombardier, Charles H.

    2015-01-01

    Objective To develop an item response theory (IRT) calibrated Grief and Loss item bank as part of the Spinal Cord Injury – Quality of Life (SCI-QOL) measurement system. Design A literature review guided framework development of grief/loss. New items were created from focus groups. Items were revised based on expert review and patient feedback and were then field tested. Analyses included confirmatory factor analysis (CFA), graded response IRT modeling and evaluation of differential item functioning (DIF). Setting We tested a 20-item pool at several rehabilitation centers across the United States, including the University of Michigan, Kessler Foundation, Rehabilitation Institute of Chicago, the University of Washington, Craig Hospital and the James J. Peters/Bronx Department of Veterans Affairs hospital. Participants A total of 717 individuals with SCI answered the grief and loss questions. Results The final calibrated item bank resulted in 17 retained items. A unidimensional model was observed (CFI = 0.976; RMSEA = 0.078) and measurement precision was good (theta range between −1.48 to 2.48). Ten items were flagged for DIF, however, after examination of effect sizes found this to be negligible with little practical impact on score estimates. Conclusions This study indicates that the SCI-QOL Grief and Loss item bank represents a psychometrically robust measurement tool. Short form items are also suggested and computer adaptive tests are available. PMID:26010969

  15. Measuring psychological trauma after spinal cord injury: Development and psychometric characteristics of the SCI-QOL Psychological Trauma item bank and short form

    PubMed Central

    Kisala, Pamela A.; Victorson, David; Pace, Natalie; Heinemann, Allen W.; Choi, Seung W.; Tulsky, David S.

    2015-01-01

    Objective To describe the development and psychometric properties of the SCI-QOL Psychological Trauma item bank and short form. Design Using a mixed-methods design, we developed and tested a Psychological Trauma item bank with patient and provider focus groups, cognitive interviews, and item response theory based analytic approaches, including tests of model fit, differential item functioning (DIF) and precision. Setting We tested a 31-item pool at several medical institutions across the United States, including the University of Michigan, Kessler Foundation, Rehabilitation Institute of Chicago, the University of Washington, Craig Hospital and the James J. Peters/Bronx Veterans Administration hospital. Participants A total of 716 individuals with SCI completed the trauma items Results The 31 items fit a unidimensional model (CFI=0.952; RMSEA=0.061) and demonstrated good precision (theta range between 0.6 and 2.5). Nine items demonstrated negligible DIF with little impact on score estimates. The final calibrated item bank contains 19 items Conclusion The SCI-QOL Psychological Trauma item bank is a psychometrically robust measurement tool from which a short form and a computer adaptive test (CAT) version are available. PMID:26010967

  16. Product and market study for Los Alamos National Laboratory. Building resources for technology commercialization: The SciBus Analytical, Inc. paradigm

    SciTech Connect

    1996-02-01

    The study project was undertaken to investigate how entrepreneurial small businesses with technology licenses can develop product and market strategies sufficiently persuasive to attract resources and exploit commercialization opportunities. The study attempts to answer two primary questions: (1) What key business development strategies are likely to make technology transfers successful, and (2) How should the plan best be presented in order to attract resources (e.g., personnel, funding, channels of distribution)? In the opinion of the investigator, Calidex Corporation, if the business strategies later prove to be successful, then the plan model has relevance for any technology licensee attempting to accumulate resources and bridge from technology resident in government laboratories to the commercial marketplace. The study utilized SciBus Analytical, Inc. (SciBus), a Los Alamos National Laboratory CRADA participant, as the paradigm small business technology licensee. The investigator concluded that the optimum value of the study lay in the preparation of an actual business development plan for SciBus that might then have, hopefully, broader relevance and merit for other private sector technology transfer licensees working with various Government agencies.

  17. The psychometric properties of Chinese version of SCI Exercise Self-Efficacy Scale in patients with stroke

    PubMed Central

    Dong, Xiaofang; Liu, Yanjin; Wang, Aixia; Wang, Min

    2016-01-01

    Objective To test the Chinese version of the SCI Exercise Self-Efficacy Scale (C-ESES) in stroke patients and evaluate its validity and reliability. Background Physical inactivity is a well established and changeable risk factor for stroke, and regular exercise of 3–7 days per week is essential for stroke survivors and the general population. Though regular exercise is beneficial, it has been proved that duration, frequency, and intensity of exercise are generally low in stroke survivors. Methods The performance of the instrument was assessed in 350 Chinese stroke survivors and repeated in 50 patients to examine test–retest reliability. Questionnaires included a form on demographic and socioeconomic characteristics, C-ESES, and the Chinese version of the General Self-Efficacy Scale. The AMOS 20.0 and SPSS 17.0 were chosen to evaluate their validity and reliability. Results Even though 350 participants answered the questionnaires in the present study, useful data were obtained from 321 participants (response rate: 91.71%). Correlation between item and the total scale score (Item–Total Correlation) ranged from 0.551 to 0.718, indicating that no item needed to be omitted; two factors, with factor loading 0.620 and 0.806, were obtained from an exploratory principal components analysis, assuming 59.745% of the total variance. The two factors were named internal motivation and external motivation. A confirmatory factor analysis supported the results with a suitable model (χ5=291.157; df=185; P<0.001; root mean square error of approximation =0.044; goodness-of-fit index =0.938; adjusted goodness-of-fit index =0.914; comparative fit index =0.858). The C-ESES correlated well with the validated General Self-Efficacy Scale (r=0.827, P<0.01). Good internal consistency (Cronbach’s α=0.757 to 0.879) and test–retest reliability (r=0.750, P<0.01) were obtained. Conclusion The C-ESES is a short, easy to understand, and psychometrically sound measurement to evaluate

  18. Meeting Report: International nephrology days - In honor of the 75(th) anniversary of acad. Momir Polenakovic and 50 years of scientific work, 26-27 September 2014.

    PubMed

    Spasovski, G

    2015-01-01

    The International Nephrology Days in honor of the 75(th) anniversary of Academician Momir Polenakovic and 50 years of his scientific work were held in the Macedonian Academy of Sciences and Arts (MASA) on 26 and 27 September 2014. Organizers of the meeting were the Macedonian Academy of Sciences and Arts and the Macedonian Society of Nephrology, Dialysis, Transplantation and Artificial Organs (MSNDTAO). The days were programmed with the VII Macedonian-Croatian Nephrology Meeting and the Continuing Medical Education (CME) Course on "Renal Replacement Therapy - when & how - update on the outcome and cost-efficacy" organized by the MSNDTAO in cooperation with the European Renal Association (ERA-EDTA). Prominent academicians, researchers and nephrologists from Europe and neighboring countries contributed with their lectures and discussion at this scientific event. On September 26, 2014 the opening talk was given by Acad. V. Kambovski, President of the MASA, about the Life and Work of Academician Momir Polenakovic. In honor of his anniversary and valuable scientific opus, during the meeting Acad. Momir Polenakovic was awarded with Certificate of the European Renal Association (ERA-EDTA) for his significant role in the development of nephrology in the Balkan region and couple of other diplomas and acknowledgement. Prof. Polenakovic is founder of the MSNDTAO and his lifetime honorary president.

  19. Compound heterozygous mutations of ACADS gene in newborn with short chain acyl-CoA dehydrogenase deficiency: case report and literatures review

    PubMed Central

    An, Se Jin; Kim, Sook Za; Kim, Gu Hwan; Yoo, Han Wook

    2016-01-01

    Short-chain acyl-CoA dehydrogenase deficiency (SCADD) is a rare autosomal recessive mitochondrial disorder of fatty acid β-oxidation, and is associated with mutations in the acyl-CoA dehydrogenase (ACADS) gene. Recent advances in spectrometric screening for inborn errors of metabolism have helped detect several metabolic disorders, including SCADD, without symptoms in the neonate period. This allows immediate initiation of treatment and monitoring, so they remain largely symptomless metabolic disease. Here, we report a 15-month-old asymptomatic male, who was diagnosed with SCADD by newborn screening. Spectrometric screening for inborn errors of metabolism 72 hours after birth revealed an elevated butyrylcarnitine (C4) concentration of 2.25 µmol/L (normal, <0.99 µmol/L). Urinary excretion of ethylmalonic acid was also elevated, as detected by urine organic acid analysis. To confirm the diagnosis of SCADD, direct sequencing analysis of 10 coding exons and the exon-intron boundaries of the ACADS gene were performed. Subsequent sequence analysis revealed compound heterozygous missense mutations c.164C>T (p.Pro55Leu) and c.1031A>G (p.Glu344Gly) on exons 2 and 9, respectively. The patient is now growing up, unretarded by symptoms such as seizure and developmental delay. PMID:28018444

  20. Final Report on DOE SciDAC project on Next Generation of Multi-Scale Quantum Simulation Software for Strongly Correlated Materials

    SciTech Connect

    Bai, Zhaojun; Scalettar, Richard; Savrasov, Sergey

    2012-07-01

    This report summarizes the accomplishments of the University of California Davis team which is part of a larger SciDAC collaboration including Mark Jarrell of Louisiana State University, Karen Tomko of the Ohio Supercomputer Center, and Eduardo F. D'Azevedo and Thomas A. Maier of Oak Ridge National Laboratory. In this report, we focus on the major UCD accomplishments. As the paper authorship list emphasizes, much of our work is the result of a tightly integrated effort; hence this compendium of UCD efforts of necessity contains some overlap with the work at our partner institutions.

  1. Building Infrastructure to Accelerate Transfer of Basic Research in Spinal Cord Injury (SCI) to Clinical Practice: North American Clinical Trials Network

    DTIC Science & Technology

    2013-08-01

    Association for Collaborative Spine Research annual meeting in Chicago at the end of July and they will meet separately to decide how best to move forward with...Mild and moderate elevation of ALT and AST in SCI patients, as reported by Shepard and Bracken,23 was confirmed to occur within the first day of...Spine (Suppl.) 17, 119–128. 23. Shepard , M.J., and Bracken, M.B. (1994). The effect of methyl- prednisilone, naloxone, and spinal cord trauma on

  2. Comment on ``Implementing of a precision fast thermoelectric cooler using a personal computer parallel port connection and ADN8830 controller'' [Rev. Sci. Instrum. 74, 3862 (2003)

    NASA Astrophysics Data System (ADS)

    Sloman, A. W.

    2004-03-01

    Eli Flaxer has described a feedback controlled circuit to drive a Peltier junction to control the temperature of a specimen in the range 0 to 50 °C in a room temperature environment [Rev. Sci. Instrum. 74, 3862 (2003)]. The amount of heat transferred per unit current by a Peltier junction varies substantially with the temperature difference across the Peltier junction. Flaxer's circuit does not provide any mechanism to compensate for this variation. This means that if the proportional-integral-differential control loop he uses is optimized at any particular temperature differential, the control loop with be over-damped at lower specimen temperatures, and under-damped at higher specimen temperatures. A circuit using a second thermistor to monitor the temperature of the exhaust side of the Peltier junction, and a digital control loop, can minimize this problem [A. W. Sloman, Paul Buggs, James Molloy, and Douglas Stewart, Meas. Sci. Technol. 7, 1653 (1996)]. This circuit has the incidental advantage of offering ten times better temperature stability.

  3. Final Report for "Tech-X Corporation work for the SciDAC Center for Simulation of RF Wave Interactions with Magnetohydrodynamics (SWIM)"

    SciTech Connect

    Jenkins, Thomas G.; Kruger, Scott E.

    2013-03-25

    Work carried out by Tech-X Corporation for the DoE SciDAC Center for Simulation of RF Wave Interactions with Magnetohydrodynamics (SWIM; U.S. DoE Office of Science Award Number DE-FC02-06ER54899) is summarized and is shown to fulfil the project objectives. The Tech-X portion of the SWIM work focused on the development of analytic and computational approaches to study neoclassical tearing modes and their interaction with injected electron cyclotron current drive. Using formalism developed by Hegna, Callen, and Ramos [Phys. Plasmas 16, 112501 (2009); Phys. Plasmas 17, 082502 (2010); Phys. Plasmas 18, 102506 (2011)], analytic approximations for the RF interaction were derived and the numerical methods needed to implement these interactions in the NIMROD extended MHD code were developed. Using the SWIM IPS framework, NIMROD has successfully coupled to GENRAY, an RF ray tracing code; additionally, a numerical control system to trigger the RF injection, adjustment, and shutdown in response to tearing mode activity has been developed. We discuss these accomplishments, as well as prospects for ongoing future research that this work has enabled (which continue in a limited fashion under the SciDAC Center for Extended Magnetohydrodynamic Modeling (CEMM) project and under a baseline theory grant). Associated conference presentations, published articles, and publications in progress are also listed.

  4. Anti-preS responses influence the anti-HBs response in newborns after vaccination with the third generation Sci-B-Vac vaccine.

    PubMed

    Sylvan, Staffan P E; Madalinski, Kazimierz; Hellström, Ulla B

    2009-12-11

    We analysed the specificity and significance of the antibody response towards the linear preS1 sequence that has been shown to represent the "hepatocyte binding site" comprising amino acids preS1 (21-47) or the specific preS2 (131-140) antibody response to the "polymerised albumin receptor" in relation to the antibody response to hepatitis B surface antigen during immunisation of healthy children with the preS-containing Sci-B-Vac vaccine. Twenty-eight healthy newborns received three doses of the Sci-B-Vac vaccine according to a 0-, 1-, and 6-month scheme. Seventeen (61%) of the 28 newborns had detectable levels of anti-preS1 (21-47) antibodies and 14 (50%) were anti-preS2 (131-140) reactive at 6 and/or 9 months after initiation of the vaccination. The mean levels of anti-HBs were significantly higher in the anti-preS2 (131-140) non-reactive (24580+/-7815IU/l, mean+SEM) compared with the reactive sera (7287+/-2317IU/l, p<0.025). The highest anti-HBs levels were found in newborns who exhibited reactivity towards the aa 21-47 of the preS1 but lacked anti-preS2 (131-140) reactivity.

  5. Sterilization-CO2-Injection (SCI) BaPS: Establishment of a new method to measure rates of soil respiration and gross nitrification in calcareous agricultural soils

    NASA Astrophysics Data System (ADS)

    Conrads, Hannah; Ingwersen, Joachim; Streck, Thilo

    2013-04-01

    Soil respiration and nitrification are key processes in carbon and nitrogen cycling in soil. An exact measurement of these two processes is a prerequisite for understanding the release of trace gases from soils. During the last decades the Barometric Process Separation (BaPS) method has become a widely used method to measure the turnover rates of these two processes. Its application, however, is currently limited to acidic to slightly acidic soils. In calcareous soils huge amounts of CO2 from soil respiration are dissolved in the soil solution, and the application of the BaPS method is hampered by the exact quantification of this flux. Small errors in this flux may result in huge errors in the calculation of the nitrification and respiration rates. In order to overcome this shortcoming and to extend the applicability of the method to a wider range of soils (especially agricultural soils) we developed a new adaptive method, the Sterilization-CO2-Injection (SCI) method, which aims to determine the CO2 dissolution flux (CO2,aq) experimentally. Therefore, an additional measuring step is introduced in which a sterilized soil subsample is incubated in the BaPS apparatus and known amounts of a pure CO2 gas are injected into the system while CO2 partial pressure is monitored. After each injection peak CO2 partial pressure decreases until a new stable equilibrium concentration is reached. This behavior is used to compute the amount of CO2 transferred to the soil solution applying simple mass balance calculation. The paired information about CO2 and CO2,aq is used to derive a regression equation, which gives CO2,aq as a function of the CO2 partial pressure. This relation is further used within the standard BaPS method. Results of the SCI-BaPS method for gross nitrification rates will be presented and compared to data measured by the 15N pool dilution method (Kirkham and Bartholomew, 1954). Results were obtained with calcareous and acidic agricultural soil samples. It turned

  6. [Comparison and thinking on literatures of low back pain treated with acupuncture-moxibustion published in foreign SCI journals and domestic core journals].

    PubMed

    Lin, Xiang-Jun; Li, Rui

    2012-07-01

    The literatures of clinical research on acupuncture treatment of low back pain included in foreign SCI journals as well as the domestic core journals in the recent 10 years were collected in this article to discuss the divergence of views domestically and abroad. The result showed that acute and chronic back pain and low back pain were generally set as the targets of research abroad. While, diseases with western diagnosis such as lumbar disc herniation was often set as the study target by domestic researchers. It indicats that divergence existed in understanding and study methods between Chinese and foreign research fellows. Thus, comparison should be carried out so as to learn from the strong points of each other and close the gap.

  7. Comment on Neiser et al. Assessment of Dextran Antigenicity of Intravenous Iron Preparations with Enzyme-Linked Immunosorbent Assay (ELISA). Int. J. Mol. Sci. 2016, 17, 1185.

    PubMed

    Strom, Claes C; Andreasen, Hans B

    2017-01-10

    All IV iron complexes carry a risk of potentially fatal allergic type hypersensitivity reactions. The mechanism(s) behind these reactions is unknown but the limited data available suggests that classic IgE mediated allergy is exceedingly rare, if ever occurring. Iron-carbohydrate molecules are complex nano-particles and trying to reduce the risk of serious hypersensitivity to antibody binding of an artificial antibody seems meaningless. A recently published analysis of safety data from randomized clinical trials confirms the method reported by Neiser to be useless to predict reaction risk. In conclusion, the study by Neiser et al. is biased, contains no new information, and has no clinical relevance. We are concerned that the association of the authors with a commercial entity has caused a conflict of interest that biases not only the results, but the entire experimental setup against competitors. (Comment on Neiser et al. Int. J. Mol. Sci. 2016, 17, 1185, doi:10.3390/ijms17071185).

  8. PROBING THE DARK AGES AT z ∼ 20: THE SCI-HI 21 cm ALL-SKY SPECTRUM EXPERIMENT

    SciTech Connect

    Voytek, Tabitha C.; Natarajan, Aravind; Peterson, Jeffrey B.; Jáuregui García, José Miguel; López-Cruz, Omar

    2014-02-10

    We present first results from the SCI-HI experiment, which we used to measure the all-sky-averaged 21 cm brightness temperature in the redshift range 14.8 < z < 22.7. The instrument consists of a single broadband sub-wavelength size antenna and a sampling system for real-time data processing and recording. Preliminary observations were completed in 2013 June at Isla Guadalupe, a Mexican biosphere reserve located in the Pacific Ocean. The data was cleaned to excise channels contaminated by radio frequency interference, and the system response was calibrated by comparing the measured brightness temperature to the Global Sky Model of the Galaxy and by independent measurement of Johnson noise from a calibration terminator. We present our results, discuss the cosmological implications, and describe plans for future work.

  9. Evaluation of unique identifiers used as keys to match identical publications in Pure and SciVal – a case study from health science

    PubMed Central

    Madsen, Heidi Holst; Madsen, Dicte; Gauffriau, Marianne

    2016-01-01

    Unique identifiers (UID) are seen as an effective key to match identical publications across databases or identify duplicates in a database. The objective of the present study is to investigate how well UIDs work as match keys in the integration between Pure and SciVal, based on a case with publications from the health sciences. We evaluate the matching process based on information about coverage, precision, and characteristics of publications matched versus not matched with UIDs as the match keys. We analyze this information to detect errors, if any, in the matching process. As an example we also briefly discuss how publication sets formed by using UIDs as the match keys may affect the bibliometric indicators number of publications, number of citations, and the average number of citations per publication.  The objective is addressed in a literature review and a case study. The literature review shows that only a few studies evaluate how well UIDs work as a match key. From the literature we identify four error types: Duplicate digital object identifiers (DOI), incorrect DOIs in reference lists and databases, DOIs not registered by the database where a bibliometric analysis is performed, and erroneous optical or special character recognition. The case study explores the use of UIDs in the integration between the databases Pure and SciVal. Specifically journal publications in English are matched between the two databases. We find all error types except erroneous optical or special character recognition in our publication sets. In particular the duplicate DOIs constitute a problem for the calculation of bibliometric indicators as both keeping the duplicates to improve the reliability of citation counts and deleting them to improve the reliability of publication counts will distort the calculation of average number of citations per publication. The use of UIDs as a match key in citation linking is implemented in many settings, and the availability of UIDs may become

  10. Evaluation of unique identifiers used as keys to match identical publications in Pure and SciVal - a case study from health science.

    PubMed

    Madsen, Heidi Holst; Madsen, Dicte; Gauffriau, Marianne

    2016-01-01

    Unique identifiers (UID) are seen as an effective key to match identical publications across databases or identify duplicates in a database. The objective of the present study is to investigate how well UIDs work as match keys in the integration between Pure and SciVal, based on a case with publications from the health sciences. We evaluate the matching process based on information about coverage, precision, and characteristics of publications matched versus not matched with UIDs as the match keys. We analyze this information to detect errors, if any, in the matching process. As an example we also briefly discuss how publication sets formed by using UIDs as the match keys may affect the bibliometric indicators number of publications, number of citations, and the average number of citations per publication.  The objective is addressed in a literature review and a case study. The literature review shows that only a few studies evaluate how well UIDs work as a match key. From the literature we identify four error types: Duplicate digital object identifiers (DOI), incorrect DOIs in reference lists and databases, DOIs not registered by the database where a bibliometric analysis is performed, and erroneous optical or special character recognition. The case study explores the use of UIDs in the integration between the databases Pure and SciVal. Specifically journal publications in English are matched between the two databases. We find all error types except erroneous optical or special character recognition in our publication sets. In particular the duplicate DOIs constitute a problem for the calculation of bibliometric indicators as both keeping the duplicates to improve the reliability of citation counts and deleting them to improve the reliability of publication counts will distort the calculation of average number of citations per publication. The use of UIDs as a match key in citation linking is implemented in many settings, and the availability of UIDs may become

  11. Modified spectral count index (mSCI) for estimation of protein abundance by protein relative identification possibility (RIPpro): a new proteomic technological parameter.

    PubMed

    Sun, Aihua; Zhang, Jiyang; Wang, Chunping; Yang, Dong; Wei, Handong; Zhu, Yunping; Jiang, Ying; He, Fuchu

    2009-11-01

    Peptides Count (SC) was widely used for protein abundance estimation in proteomics. On the basis of that, Mann and co-workers corrected the SC by dividing spectrum counts by the number of observable peptides per protein and named it PAI. Here we present modified spectral count index (mSCI) for protein abundance estimation, which was defined as the number of observed peptides divided by protein relative identification possibility (RIPpro). RIPpro was derived from 6788 mRNA and protein expression data (collected from human liver samples) and related to proteins' three physical and chemical properties (MW/pI/Hp). For 46 proteins in mouse neuro2a cells, mSCI shows a linear relationship with the actual protein concentration, similar or better than PAI abundance. Also, multiple linear regressions were performed to quantitative assess several factors' impact on the mRNA/protein abundance correlation. Our results shown that the primary factor affecting protein levels was mRNA abundance (32-37%), followed by variability in protein measurement, MW and protein turnover (7-12%,7-9% and 2-3%, respectively). Interestingly, we found that the concordance between mRNA transcripts and protein expression was not consistent among all protein functional categories. This correlation was lower for signaling proteins as compared to metabolism genes. It was determined that RIPpro was the primary factor affecting signaling protein abundance (23% on average), followed by mRNA abundance (17%). In contrast, only 5% (on average) of the variability of metabolic protein abundance was explained by RIPpro, much lower than mRNA abundance (40%). These results provide the impetus for further investigation of the biological significance of mechanisms regulating the mRNA/protein abundance correlation and provide additional insight into the relative importance of the technological parameter (RIPpro) in mRNA/protein correlation research.

  12. Impact of locomotion training with a neurologic controlled hybrid assistive limb (HAL) exoskeleton on neuropathic pain and health related quality of life (HRQoL) in chronic SCI: a case study (.).

    PubMed

    Cruciger, Oliver; Schildhauer, Thomas A; Meindl, Renate C; Tegenthoff, Martin; Schwenkreis, Peter; Citak, Mustafa; Aach, Mirko

    2016-08-01

    Chronic neuropathic pain (CNP) is a common condition associated with spinal cord injury (SCI) and has been reported to be severe, disabling and often treatment-resistant and therefore remains a clinical challenge for the attending physicians. The treatment usually includes pharmacological and/or nonpharmacological approaches. Body weight supported treadmill training (BWSTT) and locomotion training with driven gait orthosis (DGO) have evolved over the last decades and are now considered to be an established part in the rehabilitation of SCI patients. Conventional locomotion training goes along with improvements of the patients' walking abilities in particular speed and gait pattern. The neurologic controlled hybrid assistive limb (HAL®, Cyberdyne Inc., Ibraki, Japan) exoskeleton, however, is a new tailored approach to support motor functions synchronously to the patient's voluntary drive. This report presents two cases of severe chronic and therapy resistant neuropathic pain due to chronic SCI and demonstrates the beneficial effects of neurologic controlled exoskeletal intervention on pain severity and health-related quality of life (HRQoL). Both of these patients were engaged in a 12 weeks period of daily HAL®-supported locomotion training. In addition to improvements in motor functions and walking abilities, both show significant reduction in pain severity and improvements in all HRQoL domains. Although various causal factors likely contribute to abatement of CNP, the reported results occurred due to a new approach in the rehabilitation of chronic spinal cord injury patients. These findings suggest not only the feasibility of this new approach but in conclusion, demonstrate the effectiveness of neurologic controlled locomotion training in the long-term management of refractory neuropathic pain. Implications for Rehabilitation CNP remains a challenge in the rehabilitation of chronic SCI patients. Locomotion training with the HAL exoskeleton seems to improve CNP

  13. Discussion of “Geomechanical modeling of the nucleation process of Australia's 1989 M5.6 Newcastle earthquake” by C.D. Klose [Earth Planet. Sci. Lett. 256 (2007) 547 553

    NASA Astrophysics Data System (ADS)

    Quinn, C. D.; Glen, R. A.; Diessel, C. F. K.

    2008-05-01

    On the basis of a numerical simulation, Klose [Earth Planet. Sci. Lett. 256: 547-553 (2007)] proposed that the MW = 5.2-5.6 earthquake that nucleated beneath Newcastle (New South Wales, Australia) at 10.30 AM December 28, 1989 (AEST), was the result of 200yr of coal mining in the region. We argue here that Klose's [Earth Planet. Sci. Lett. 256: 547-553 (2007)] ultimate conclusion is not supported by his own model or by available geological and seismic data. In particular, the 1989 Newcastle earthquake was not anomalous with respect to regional seismic activity.

  14. SciDAC's Earth System Grid Center for Enabling Technologies Semi-Annual Progress Report for the Period April 1, 2009 through September 30, 2009

    SciTech Connect

    Williams, Dean N.; Foster, I. T.; Middleton, D. E.

    2009-10-15

    This report summarizes work carried out by the ESG-CET during the period April 1, 2009 through September 30, 2009. It includes discussion of highlights, overall progress, period goals, collaborations, papers, and presentations. To learn more about our project, and to find previous reports, please visit the Earth System Grid Center for Enabling Technologies (ESG-CET) website. This report will be forwarded to the DOE SciDAC program management, the Office of Biological and Environmental Research (OBER) program management, national and international collaborators and stakeholders (e.g., the Community Climate System Model (CCSM), the Intergovernmental Panel on Climate Change (IPCC) 5th Assessment Report (AR5), the Climate Science Computational End Station (CCES), the SciDAC II: A Scalable and Extensible Earth System Model for Climate Change Science, the North American Regional Climate Change Assessment Program (NARCCAP), and other wide-ranging climate model evaluation activities). During this semi-annual reporting period, the ESG-CET team continued its efforts to complete software components needed for the ESG Gateway and Data Node. These components include: Data Versioning, Data Replication, DataMover-Lite (DML) and Bulk Data Mover (BDM), Metrics, Product Services, and Security, all joining together to form ESG-CET's first beta release. The launch of the beta release is scheduled for late October with the installation of ESG Gateways at NCAR and LLNL/PCMDI. Using the developed ESG Data Publisher, the ESG II CMIP3 (IPCC AR4) data holdings - approximately 35 TB - will be among the first datasets to be published into the new ESG enterprise system. In addition, the NCAR's ESG II data holdings will also be published into the new system - approximately 200 TB. This period also saw the testing of the ESG Data Node at various collaboration sites, including: the British Atmospheric Data Center (BADC), the Max-Planck-Institute for Meteorology, the University of Tokyo Center for

  15. Comment on Neiser et al. Assessment of Dextran Antigenicity of Intravenous Iron Preparations with Enzyme-Linked Immunosorbent Assay (ELISA). Int. J. Mol. Sci. 2016, 17, 1185.

    PubMed Central

    Strom, Claes C.; Andreasen, Hans B.

    2017-01-01

    All IV iron complexes carry a risk of potentially fatal allergic type hypersensitivity reactions. The mechanism(s) behind these reactions is unknown but the limited data available suggests that classic IgE mediated allergy is exceedingly rare, if ever occurring. Iron–carbohydrate molecules are complex nano-particles and trying to reduce the risk of serious hypersensitivity to antibody binding of an artificial antibody seems meaningless. A recently published analysis of safety data from randomized clinical trials confirms the method reported by Neiser to be useless to predict reaction risk. In conclusion, the study by Neiser et al. is biased, contains no new information, and has no clinical relevance. We are concerned that the association of the authors with a commercial entity has caused a conflict of interest that biases not only the results, but the entire experimental setup against competitors. (Comment on Neiser et al. Int. J. Mol. Sci. 2016, 17, 1185, doi:10.3390/ijms17071185). PMID:28075402

  16. PMEL contributions to the collaboration: SCALING THE EARTH SYSTEM GRID TO PETASCALE DATA for the DOE SciDACs Earth System Grid Center for Enabling Technologies

    SciTech Connect

    Hankin, Steve

    2012-06-01

    Drawing to a close after five years of funding from DOE's ASCR and BER program offices, the SciDAC-2 project called the Earth System Grid (ESG) Center for Enabling Technologies has successfully established a new capability for serving data from distributed centers. The system enables users to access, analyze, and visualize data using a globally federated collection of networks, computers and software. The ESG software now known as the Earth System Grid Federation (ESGF) has attracted a broad developer base and has been widely adopted so that it is now being utilized in serving the most comprehensive multi-model climate data sets in the world. The system is used to support international climate model intercomparison activities as well as high profile U.S. DOE, NOAA, NASA, and NSF projects. It currently provides more than 25,000 users access to more than half a petabyte of climate data (from models and from observations) and has enabled over a 1,000 scientific publications.

  17. [SciELO Public Health: the performance of Cadernos de Saúde Pública and Revista de Saúde Pública].

    PubMed

    Barata, Rita Barradas

    2007-12-01

    The aim of this paper was to analyze two Brazilian scientific journals included in the SciELO Library of Public Health, using a group of bibliometric indicators and scrutinizing the articles most viewed. Cadernos de Saúde Pública was accessed 3,743.59 times per month, with an average of 30.31 citations per article. The 50 articles most viewed (6.72 to 524.5 views) were mostly published in Portuguese (92%). 42% were theoretical essays, 20% surveys, and 16% descriptive studies. 42% used argumentative techniques, 34% quantitative techniques, 18% qualitative techniques, and 6% mathematical modeling. The most common themes were: health and work (50%), epidemiology (22%), and environmental health (8%). Revista de Saúde Pública was accessed 1,590.97 times per month, with an average of 26.27 citations per article. The 50 articles most viewed (7.33 and 56.50 views) were all published in Portuguese: 46% were surveys, 14% databases analysis, and 12% systematic reviews. Quantitative techniques were adopted in 66% of such articles, while mathematical modeling was the same as observed in Cadernos de Saúde Pública, as were qualitative techniques. The most common themes were health services organization (22%), nutrition (22%), health and work (18%), epidemiology (12%), and environmental health (12%).

  18. Sex and Fertility After SCI

    MedlinePlus

    ... About Blog Facing Disability Jeff Shannon Donate Experts \\ Sex and Fertility After Spinal Cord Injury Topics Adult ... Spasticity, Physical Therapy-Lokomat Spasticity, Physical Therapy-Lokomat Sex and Fertility After Spinal Cord Injury Sex and ...

  19. Biomaterial bridges enable regeneration and re-entry of corticospinal tract axons into the caudal spinal cord after SCI: Association with recovery of forelimb function.

    PubMed

    Pawar, Kiran; Cummings, Brian J; Thomas, Aline; Shea, Lonnie D; Levine, Ariel; Pfaff, Sam; Anderson, Aileen J

    2015-10-01

    Severed axon tracts fail to exhibit robust or spontaneous regeneration after spinal cord injury (SCI). Regeneration failure reflects a combination of factors, including the growth state of neuronal cell bodies and the regeneration-inhibitory environment of the central nervous system. However, while spared circuitry can be retrained, target reinnervation depends on longitudinally directed regeneration of transected axons. This study describes a biodegradable implant using poly(lactide-co-glycolide) (PLG) bridges as a carrier scaffold to support regeneration after injury. In order to detect regeneration of descending neuronal tracts into the bridge, and beyond into intact caudal parenchyma, we developed a mouse cervical implantation model and employed Crym:GFP transgenic mice. Characterization of Crym:GFP mice revealed that descending tracts, including the corticospinal tract, were labeled by green fluorescent protein (GFP), while ascending sensory neurons and fibers were not. Robust co-localization between GFP and neurofilament-200 (NF-200) as well as GFP and GAP-43 was observed at both the rostral and caudal bridge/tissue interface. No evidence of similar regeneration was observed in mice that received gelfoam at the lesion site as controls. Minimal co-localization between GFP reporter labeling and macrophage markers was observed. Taken together, these data suggest that axons originating from descending fiber tracts regenerated, entered into the PLG bridge at the rostral margin, continued through the bridge site, and exited to re-enter host tissue at the caudal edge of the intact bridge. Finally, regeneration through implanted bridges was associated with a reduction in ipsilateral forelimb errors on a horizontal ladder task.

  20. Developing quality of care indicators for patients with traumatic and non-traumatic spinal cord injury (SCI): A feasibility study using administrative health data

    PubMed Central

    Parsons, Daria; Craven, B. Catharine; Jaglal, Susan B.; Verrier, Molly

    2015-01-01

    Objectives (1) to inform the development of health system quality indicators for traumatic and non-traumatic spinal cord injury from acute care admission to community care discharge using administrative data, and (2) to examine characteristics and differences in care among type of care facility, and type of pathology using administrative data. Design Retrospective cohort study using administrative health data. Setting Ontario, Canada. Participants Using administrative health data, we used International Classification codes 10th version Canadian Edition to identify incident cases of SCI from April 1, 2006 to March 31, 2012. Results We identified 7,693 cases in our cohort, of whom 1,537 (20.0%) were categorized as traumatic spinal cord (TSCI) and 6,156 (80.0%) as non-traumatic (NTSCI). Of those identified with NTSCI, more than half (54.0%) were diagnosed with either Guillain Barré syndrome and Multiple Sclerosis (n = 3,326). More individuals admitted to a trauma/spine center were seen by an orthopedic surgeon or a neurosurgeon (20.3% compared to 5.6% for NTSCI; 77.7% compared to 24.9% for TSCI). Only 25.7% (n = 724) of the NTSCI cohort were admitted to a rehabilitation facility from a trauma/spine center, compared to 58.9% (n = 754) of those with TSCI. Conclusions Important challenges in data completeness and utility were identified. Province wide processes to flag incomplete data and provision of incentives for comprehensive data are urgently needed to develop quality indicators across the care continuum. Consensus on the coding for NTSCI for the purposes of developing health system indicators is required. PMID:26111282

  1. Scientific Objectives of Small Carry-on Impactor (SCI) and Deployable Camera 3 Digital (DCAM3-D): Observation of an Ejecta Curtain and a Crater Formed on the Surface of Ryugu by an Artificial High-Velocity Impact

    NASA Astrophysics Data System (ADS)

    Arakawa, M.; Wada, K.; Saiki, T.; Kadono, T.; Takagi, Y.; Shirai, K.; Okamoto, C.; Yano, H.; Hayakawa, M.; Nakazawa, S.; Hirata, N.; Kobayashi, M.; Michel, P.; Jutzi, M.; Imamura, H.; Ogawa, K.; Sakatani, N.; Iijima, Y.; Honda, R.; Ishibashi, K.; Hayakawa, H.; Sawada, H.

    2016-10-01

    The Small Carry-on Impactor (SCI) equipped on Hayabusa2 was developed to produce an artificial impact crater on the primitive Near-Earth Asteroid (NEA) 162173 Ryugu (Ryugu) in order to explore the asteroid subsurface material unaffected by space weathering and thermal alteration by solar radiation. An exposed fresh surface by the impactor and/or the ejecta deposit excavated from the crater will be observed by remote sensing instruments, and a subsurface fresh sample of the asteroid will be collected there. The SCI impact experiment will be observed by a Deployable CAMera 3-D (DCAM3-D) at a distance of ˜1 km from the impact point, and the time evolution of the ejecta curtain will be observed by this camera to confirm the impact point on the asteroid surface. As a result of the observation of the ejecta curtain by DCAM3-D and the crater morphology by onboard cameras, the subsurface structure and the physical properties of the constituting materials will be derived from crater scaling laws. Moreover, the SCI experiment on Ryugu gives us a precious opportunity to clarify effects of microgravity on the cratering process and to validate numerical simulations and models of the cratering process.

  2. Genetics Home Reference: aceruloplasminemia

    MedlinePlus

    ... PubMed Harris ZL. Aceruloplasminemia. J Neurol Sci. 2003 Mar 15;207(1-2):108-9. Review. Citation ... nervous system. Ann N Y Acad Sci. 2004 Mar;1012:267-81. Review. Citation on PubMed Vassiliev ...

  3. Final Report- "An Algorithmic and Software Framework for Applied Partial Differential Equations (APDEC): A DOE SciDAC Integrated Software Infrastructure Center (ISIC)

    SciTech Connect

    Elbridge Gerry Puckett

    2008-05-13

    been a Deputy Section Head at the National Center for Atmospheric Research in Colorado. My understanding is that Chris Algieri is the first person that Bill hired after coming to LBNL. The plan is that Chris Algieri will finish his PhD thesis while employed as a staff scientist in Bill's group. Both Sarah and Chris were supported in part with funds from DE-FC02-01ER25473. In Sarah's case she received support both while at U.C. Davis (UCD) taking classes and writing an MS thesis and during some of the time she was living in Berkeley, working at LBNL and finishing her PhD thesis. In Chris' case he was at U.C. Davis during the entire time he received support from DE-FC02-01ER25473. More specific details of their work are included in the report below. Finally my own research conducted under the auspices of DE-FC02-01ER25473 either involved direct collaboration with researchers at LBNL - Phil Colella and Peter Schwartz who is a member of Phil's Applied Numerical Algorithms Group - or was on problems that are closely related to research that has been and continues to be conducted by researchers at LBNL. Specific details of this work can be found below. Finally, I would like to note that the work conducted by my students and me under the auspices of this contract is closely related to work that I have performed with funding from my DOE MICS contract DE-FC02-03ER25579 'Development of High-Order Accurate Interface Tracking Algorithms and Improved Constitutive Models for Problems in Continuum Mechanics with Applications to Jetting' and with my CoPI on that grant Professor Greg Miller of the Department of Applied Science at UCD. In theory I tried to use funds from the SciDAC grant DE-FC02-01ER25473 to support work that directly involved implementing algorithms developed by my research group at U.C. Davis in software that was developed and is maintained by my SciDAC CoPI's at LBNL.

  4. SciDAC Fusiongrid Project--A National Collaboratory to Advance the Science of High Temperature Plasma Physics for Magnetic Fusion

    SciTech Connect

    SCHISSEL, D.P.; ABLA, G.; BURRUSS, J.R.; FEIBUSH, E.; FREDIAN, T.W.; GOODE, M.M.; GREENWALD, M.J.; KEAHEY, K.; LEGGETT, T.; LI, K.; McCUNE, D.C.; PAPKA, M.E.; RANDERSON, L.; SANDERSON, A.; STILLERMAN, J.; THOMPSON, M.R.; URAM, T.; WALLACE, G.

    2006-08-31

    This report summarizes the work of the National Fusion Collaboratory (NFC) Project funded by the United States Department of Energy (DOE) under the Scientific Discovery through Advanced Computing Program (SciDAC) to develop a persistent infrastructure to enable scientific collaboration for magnetic fusion research. A five year project that was initiated in 2001, it built on the past collaborative work performed within the U.S. fusion community and added the component of computer science research done with the USDOE Office of Science, Office of Advanced Scientific Computer Research. The project was a collaboration itself uniting fusion scientists from General Atomics, MIT, and PPPL and computer scientists from ANL, LBNL, Princeton University, and the University of Utah to form a coordinated team. The group leveraged existing computer science technology where possible and extended or created new capabilities where required. Developing a reliable energy system that is economically and environmentally sustainable is the long-term goal of Fusion Energy Science (FES) research. In the U.S., FES experimental research is centered at three large facilities with a replacement value of over $1B. As these experiments have increased in size and complexity, there has been a concurrent growth in the number and importance of collaborations among large groups at the experimental sites and smaller groups located nationwide. Teaming with the experimental community is a theoretical and simulation community whose efforts range from applied analysis of experimental data to fundamental theory (e.g., realistic nonlinear 3D plasma models) that run on massively parallel computers. Looking toward the future, the large-scale experiments needed for FES research are staffed by correspondingly large, globally dispersed teams. The fusion program will be increasingly oriented toward the International Thermonuclear Experimental Reactor (ITER) where even now, a decade before operation begins, a large

  5. Comment on 'Etch characteristics of CeO{sub 2} thin film in Ar/CF{sub 4}/Cl{sub 2} plasma' [J. Vac. Sci. Technol. A 21, 426 (2003)

    SciTech Connect

    Paparazzo, E.

    2004-09-01

    Comments are made on a recent article by Kim, Chang, and Kim [J. Vac. Sci. Technol. A 21, 426 (2003)], which describes the preparation and the x-ray photoemission spectroscopy study of the etching effects produced by Ar-based plasmas of different composition on the surface chemistry of a CeO{sub 2} film grown on Si. We discuss some chemical interactions taking place between Ce, Si, and the ambient humidity during the early stages of film deposition, and demonstrate that the many-body effects involved in Ce 3d spectra provide a key for better understanding of the etching mechanisms exerted by the plasma treatments.

  6. Performance of Hayabusa2 DCAM3-D Camera for Short-Range Imaging of SCI and Ejecta Curtain Generated from the Artificial Impact Crater Formed on Asteroid 162137 Ryugu (1999 JU3)

    NASA Astrophysics Data System (ADS)

    Ishibashi, K.; Shirai, K.; Ogawa, K.; Wada, K.; Honda, R.; Arakawa, M.; Sakatani, N.; Ikeda, Y.

    2016-11-01

    Deployable Camera 3-D (DCAM3-D) is a small high-resolution camera equipped on Deployable Camera 3 (DCAM3), one of the Hayabusa2 instruments. Hayabusa2 will explore asteroid 162137 Ryugu (1999 JU3) and conduct an impact experiment using a liner shooting device called Small Carry-on Impactor (SCI). DCAM3 will be detached from the Hayabusa2 spacecraft and observe the impact experiment. The purposes of the observation are to know the impact conditions, to estimate the surface structure of asteroid Ryugu, and to understand the physics of impact phenomena on low-gravity bodies. DCAM3-D requires high imaging performance because it has to image and detect multiple targets of different scale and radiance, i.e., the faint SCI before the shot from 1-km distance, the bright ejecta generated by the impact, and the asteroid. In this paper we report the evaluation of the performance of the CMOS imaging sensor and the optical system of DCAM3-D. We also describe the calibration of DCAM3-D. We confirmed that the imaging performance of DCAM3-D satisfies the required values to achieve the purposes of the observation.

  7. Ultrasonic Propagation in Liquids Under High Pressures

    DTIC Science & Technology

    1948-12-01

    34 Proc. Am, Acad. Arts Sci. 19, 143 (1923). 28. Bridgman P. W., "The Viscosity of Liquids under Pressure," Proc. Nat. Acad. Sci. 119 603 (1925). TM3...1932). 42. Ewell, R. H., and Eyring, H., "Theory of the Viscosity of Liquids as a Function of Temperature and Pressureg" J. Chem. Phys. 1, 726 (1937

  8. Metalloproteinase Expression is Associated with Traumatic Wound Failure

    DTIC Science & Technology

    2010-04-01

    Evaluation of immuno- assay-based MMP-8 detection in gingival crevicular fluid on a point-of-care platform. Ann NY Acad Sci 2007;1098:490. 27...Prescher N, Maier K, Munjal SK, eta!. Rapid quantitative chair- side test for active MMP-8 in gingival crevicular fluid: First clinical data. Ann NY Acad Sci 2007;1098:493.

  9. Fairy-Tale Physics Farewell to Reality Bankrupting Physics: Baggott-Unzicker-Jones Critiques Shame Physics' Shameless Media-Hype P.R. Spin-Doctoring Touting Sci-Fi Veracity-Abandonment ``Show-Biz'' Spectacle: Caveat Emptor!!!

    NASA Astrophysics Data System (ADS)

    Siegel, Edward

    2014-03-01

    Baggott[Farewell to Reality: How Fairy-Tale Physics Betrayed Search For Scientific Truth]-Unzicker [Bankrupting Physics: How Top Scientists Are Gambling Away Credibility] shame physics shameless rock-star media-hype P.R. spin-doctoring veracity-abandoning touting sci-fi show-biz aided by online proliferation of uncritical pop-sci science-writers verbal diarrhea, all spectacle vs little truth, lacking Kant-Popper skepticism/falsification, lemming-like stampedes to truth abandonment, qualified by vague adverbs: might, could, should, may,...vs factual is! Physics, motivated by financial greed, swept up in its very own hype, touts whatever next big thing/cutting-edge bombast ad infinitum/ad nauseum, turning it into mere trendy carney sideshow, full of fury(FOF) but signifying absolutely nothing! Witness: GIGO claims string-theory holographic-universe causes cuprates optical conductivity; failed Anderson RVB cuprates theory vs. Keimer discovery all cuprates ``paramagnons'' bosons aka Overhauser SDWs; Overbye NYT holographic-universe jargonial-obfuscation comments including one from APS journals editor-in-chief re. its unintelligibility, FOF but signifying absolutely nothing INTELLIGIBLE!; Bak/BNL SOC tad late rediscovery of F =ma mere renaming of Siegel acoustic-emission!; 2007 physics Nobel-prize Fert-Gruenberg rediscovery of Siegel[JMMM 7,312(78); https://www.flickr.com/search/?q=GIANT-MAGNETORESISTANCE] GMR. Each trendy latest big thing modulo lack of prior attribution aka out and out bombastic chicanery! Siegel caveat emptor ``Buzzwordism, Bandwagonism, Sloganeering for Fun Profit Survival Ego'' sociological-dysfunctionality thrives!

  10. Fairy-Tale Physics Farewell to Reality Bankrupting Physics: Baggott-Unzicker-Jones Critiques Shame Physics' Shameless Media-Hype P.R. Spin-Doctoring Touting Sci-Fi Veracity-Abandonment ``Show-Biz'' Spectacle: Caveat Emptor!!!

    NASA Astrophysics Data System (ADS)

    Siegel, Edward

    2014-03-01

    Baggott[Farewell to Reality: How Fairy-Tale Physics Betrayed Search For Scientific Truth]-Unzicker [Bankrupting Physics: How Top Scientists Are Gambling Away Credibility] shame physics shameless rock-star media-hype P.R. spin-doctoring veracity-abandoning touting sci-fi show-biz aided by online proliferation of uncritical pop-sci science-writers verbal diarrhea, all spectacle vs little truth, lacking Kant-Popper skepticism/ falsification, lemming-like stampedes to truth abandonment, qualified by vague adverbs: might, could, should, may,...vs factual is! Physics, motivated by financial greed, swept up in its very own hype, touts whatever next big thing/cutting-edge bombast ad infinitum/ad nauseum, turning it into mere trendy carney sideshow, full of fury(FOF) but signifying absolutely nothing! Witness: GIGO claims string-theory holographic-universe causes cuprates optical conductivity; failed Anderson RVB cuprates theory vs. Keimer discovery all cuprates ``paramagnons'' bosons aka Overhauser SDWs; Overbye NYT holographic-universe jargonial-obfuscation comments including one from APS journals editor-in-chief re. its unintelligibility, FOF but signifying absolutely nothing INTELLIGIBLE!; Bak/BNL SOC tad late rediscovery of F =ma mere renaming of Siegel acoustic-emission!; 2007 physics Nobel-prize Fert-Gruenberg rediscovery of Siegel[JMMM 7,312(78); https://www.flickr.com/search/?q = GIANT-MAGNETORESISTANCE] GMR. Each trendy latest big thing modulo lack of prior attribution aka out and out bombastic chicanery! Siegel caveat emptor ``Buzzwordism, Bandwagonism, Sloganeering for Fun Profit Survival Ego'' sociological-dysfunctionality thrives!

  11. The SciELO Brazilian Scientific Journal Gateway and Open Archives; Usability of Hypermedia Educational e-Books; Building Upon the MyLibrary Concept To Better Meet the Information Needs of College Students; Open Archives and UK Institutions; The Utah Digital Newspapers Project; Examples of Practical Digital Libraries.

    ERIC Educational Resources Information Center

    Marcondes, Carlos Henrique; Sayao, Luis Fernando; Diaz, Paloma; Gibbons, Susan; Pinfield, Stephen; Kenning, Arlitsch; Edge, Karen; Yapp, L.; Witten, Ian H.

    2003-01-01

    Includes six articles that focus on practical uses of technologies developed from digital library research in the areas of education and scholarship reflecting the international impact of digital library research initiatives. Includes the Scientific Electronic Library Online (SciELO) (Brazil); the National Science Foundation (NSF) (US); the Joint…

  12. Discussion on the article "Paleoseismological analysis of an intraplate extensional structure: the Concud fault (Iberian Chain, Eastern Spain)" by P. Lafuente, L. E. Arlegui, C. L. Liesa, and J. L. Simón (Int J Earth Sci)

    NASA Astrophysics Data System (ADS)

    Gutiérrez, Francisco; Lucha, Pedro; Guerrero, Jesús; Gutiérrez, Mateo; Carbonel, Domingo

    2012-03-01

    This discussion is focused on three aspects of the paper published by Lafuente et al. (Int J Earth Sci, doi: 10.1007/s00531-010-0542-1 , 2010) on Concud Fault, constitute the fundamental basis to assess the seismic potential of this capable structure: (1) A slip rate estimated for the Concud Fault based on an erroneous displacement value and a questionable correlation, obviating previously published datings, markedly different to those used by the authors. The wrong displacement value introduces an error of more than 25% in the calculated Quaternary slip rate. (2) A new paleoseismological interpretation of the outcrop of Condud Fault at Los Baños, adding two improperly justified paleoearthquakes to the four events previously inferred. (3) The attribution of faults affecting a young terrace to the most recent recorded earthquake on Concud Fault, ruling out implicitly the likely option of a gravitational origin for them, either landsliding or subsidence due to evaporite dissolution.

  13. Sustaining and Extending the Open Science Grid: Science Innovation on a PetaScale Nationwide Facility (DE-FC02-06ER41436) SciDAC-2 Closeout Report

    SciTech Connect

    Livny, Miron; Shank, James; Ernst, Michael; Blackburn, Kent; Goasguen, Sebastien; Tuts, Michael; Gibbons, Lawrence; Pordes, Ruth; Sliz, Piotr; Deelman, Ewa; Barnett, William; Olson, Doug; McGee, John; Cowles, Robert; Wuerthwein, Frank; Gardner, Robert; Avery, Paul; Wang, Shaowen; Lincoln, David Swanson

    2015-02-11

    Under this SciDAC-2 grant the project’s goal w a s t o stimulate new discoveries by providing scientists with effective and dependable access to an unprecedented national distributed computational facility: the Open Science Grid (OSG). We proposed to achieve this through the work of the Open Science Grid Consortium: a unique hands-on multi-disciplinary collaboration of scientists, software developers and providers of computing resources. Together the stakeholders in this consortium sustain and use a shared distributed computing environment that transforms simulation and experimental science in the US. The OSG consortium is an open collaboration that actively engages new research communities. We operate an open facility that brings together a broad spectrum of compute, storage, and networking resources and interfaces to other cyberinfrastructures, including the US XSEDE (previously TeraGrid), the European Grids for ESciencE (EGEE), as well as campus and regional grids. We leverage middleware provided by computer science groups, facility IT support organizations, and computing programs of application communities for the benefit of consortium members and the US national CI.

  14. SciDAC Computational Astrophysics Consortium

    SciTech Connect

    Burrows, Adam

    2008-06-18

    Supernova explosions are the central events in nuclear astrophysics. The core-collapse variety is a major source for the universe's heavy elements. The neutron stars, pulsars, and stellar-mass black holes of high-energy astrophysics are their products. Given their prodigious explosion energies, they are the major agencies of change in the interstellar medium, driving star formation and the evolution of galaxies. Their gas remnants are the birthplaces of the cosmic rays. Such is their brightness that they can be used as standard candles to measure the size and geometry of the universe. Recently, there is evidence that gamma-ray bursts (GRBs) originate in a small fraction of core collapses, thereby connecting two of the most energetic phenomena in the universe. However, the mechanism by which core-collapse supernovae explode has not yet been unambiguously determined. Arguably, this is one of the great unsolved problems in modern astrophysics and its investigation draws on nuclear physics, particle physics, radiative transfer, kinetic theory, gravitational physics, thermodynamics, and the numerical arts. Hence, supernovae are unrivaled astrophysical laboratories. It is the quest for the mechanism and new insights our team has recently had that motivate this proposal.

  15. Training-Induced Functional Gains following SCI

    PubMed Central

    Ward, P. J.; Herrity, A. N.; Harkema, S. J.; Hubscher, C. H.

    2016-01-01

    We previously demonstrated that daily, hour-long training sessions significantly improved both locomotor (limb kinematics, gait, and hindlimb flexor-extensor bursting patterns) and nonlocomotor (bladder function and at-level mechanical allodynia) functions following a moderate contusive spinal cord injury. The amount of training needed to achieve this recovery is unknown. Furthermore, whether this recovery is induced primarily by neuronal activity below the lesion or other aspects related to general exercise is unclear. Therefore, the current study objectives were to (1) test the efficacy of 30 minutes of step training for recovery following a clinically relevant contusion injury in male Wistar rats and (2) test the efficacy of training without hindlimb engagement. The results indicate that as little as 30 minutes of step training six days per week enhances overground locomotion in male rats with contusive spinal cord injury but does not alter allodynia or bladder function. Thirty minutes of forelimb-only exercise did not alter locomotion, allodynia, or bladder function, and neither training protocol altered the amount of in-cage activity. Taken together, locomotor improvements were facilitated by hindlimb step training for 30 minutes, but longer durations of training are required to affect nonlocomotor systems. PMID:27403345

  16. How Is Spinal Cord Injury (SCI) Diagnosed?

    MedlinePlus

    ... the standard ASIA (American Spinal Injury Association) Impairment Scale for this diagnosis. X-rays, MRIs, or more ... entire length of the spine. The ASIA Impairment Scale has five classification levels, ranging from complete loss ...

  17. Best of 2009 Sci-Tech Books

    ERIC Educational Resources Information Center

    Sapp, Gregg

    2010-01-01

    Science often reflects society's concerns, and a number of the top books of 2009 address two of the biggest headline-grabbing topics--climate change and health-care reform. This article presents a list of 35 titles that address climate change and health-care reform. Some titles cover the entirety of the global-warming threat (James Lovelock's "The…

  18. Best Sci-Tech Books of 2008

    ERIC Educational Resources Information Center

    Sapp, Gregg

    2009-01-01

    In tight economic times, the concerns and issues of science, viewed as not having enough practical value, can get pushed aside. But the top science books of 2008 demonstrate how science more often than not pays for itself. What's more practical than food (Tomorrow's Table), health (Our Daily Meds), the environment (The Hot Topics), or even--sex…

  19. Sci-Tech Archives and Manuscript Collections.

    ERIC Educational Resources Information Center

    Mount, Ellis, Ed.

    1989-01-01

    Selected collections of scientific and technical archives and manuscripts described in eight articles include the Edison Archives; American Museum of Natural History Library; MIT (Massachusetts Institute of Technology) Institute Archives and Special Collections; National Archives; Dard Hunter Paper Museum; American Zoo and Aquarium Archives; and…

  20. Weight Management Following SCI (Spinal Cord Injury)

    MedlinePlus

    ... eat more vegetables than fruits, more fruits than starches, more starches than meat and dairy foods, and more meat ... fats. 5 F OOD G ROUPS Vegetables Fruits Starches & Grains Meats & Dairies Fats & Oils Your body actually ...

  1. Treatment of Post-SCI Hypotension

    ClinicalTrials.gov

    2017-01-13

    Spinal Cord Injury; Autonomic Dysreflexia; Orthostatic Hypotension; Baroreceptor Integrity; Sympathetic Integrity; Vagal Integrity; Hypotension; Cerebral Blood Flow; Blood Pressure; Venous Occlusion Plethysmography

  2. "Sustaining the Shrinking City: Concepts, Dynamics and Management" (A special issue of Sustainability) (ISSN 2071-1050).

    EPA Science Inventory

    Sustainability can be broadly defined as the resilient outcome of the interaction among social equity, economic stability, and environmental quality factors. For example, the utilization of natural resource capitals are constrained by economic forces, and further modulated by soc...

  3. A bibliography for the conclusions to the special issue of Science of the Total Environment concerning 'The water quality of UK rivers entering the North Sea'. Sci. Tot. Environ., this volume.

    PubMed

    Neal, C; Turner, H

    2000-05-05

    In this document, a bibliography for the conclusions to the special issue of Science of the Total Environment concerning 'The water quality of UK rivers entering the North Sea'. Sci. Tot. Environ., this volume, is presented. It comprises a list of the papers presented in five special issues in learned journals, three in Science of the Total Environment (this volume and volumes 194/195, 1997 and 210/211, 1998) as well as Hydrological Processes (1999, vol 13: Special Issue, River Basin Sediment Dynamics, eds. Anderson, M.G., Peters, N.E. and Walling, D.E.) and Marine Pollution Bulletin [1999, vol 37(3-7) Special Issue: Flux of Materials between Rivers and Coastal Waters, eds. Stebbing, A.R.D., Huntley, D. and Leeks, G.J.L.]. The bibliography comprises six main sections with subsections for specific water quality issues. These are as follows: Section 1 deals with the introduction to LOIS and contained in this section is background material over the nature of the programme, the study area, remit, water quality issues and international context. Section 2 provides the main meat to the bibliography and it splits into Section 2.1 historical and Section 2.2 current water quality issues. Within Section 2.2 there are subsections dealing with specific current aspects of water quality (Section 2.2.1, major ions; Section 2.2.2, pH, dissolved carbon dioxide and dissolved oxygen; Section 2.2.3 nutrients; Section 2.2.4, trace elements; Section 2.2.5 micro-organics; Section 2.2.6 sediments; Section 2.2.7 biology). Section 3 deals with hydrology and climate variability, Section 4, modelling, Section 5 load estimation and Section 6 conclusions. A full listing of the LOIS programme is available from the LOIS programme office, CCMS, Plymouth Laboratory, Prospect Place, West Hoe, Plymouth, PL1 3DH, UK (e-mail lois@ccms.ac.uk).

  4. 77 FR 24497 - Government-Owned Inventions; Availability for Licensing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-24

    .... Exendin-4 ameliorates motor neuron degeneration in cellular and animal models of amyotrophic lateral... neurons in cellular and rodent models of stroke and Parkinsonism. Proc Natl Acad Sci USA. 2009 Jan...

  5. Genetics Home Reference: CHST3-related skeletal dysplasia

    MedlinePlus

    ... new recessive type of SED with progressive spinal involvement. Am J Med Genet A. 2004 May 1; ... results in severe human chondrodysplasia with progressive spinal involvement. Proc Natl Acad Sci U S A. 2004 Jul ...

  6. Genetics Home Reference: carbonic anhydrase VA deficiency

    MedlinePlus

    ... people with carbonic anhydrase VA deficiency have excess ammonia in the blood (hyperammonemia), problems with acid-base ... anhydrases VA and VB implicates both enzymes in ammonia detoxification and glucose metabolism. Proc Natl Acad Sci ...

  7. Social Support and Endocrine Function: A Randomized Trial with Breast Cancer Patients

    DTIC Science & Technology

    1999-08-01

    Psychol 1985:4: the immune response to influenza virus vaccine issues in behavioral immunology research with 25-41. in older adults. Proc Nat] Acad Sci U S...alters the immune response to influenza virus vaccine in older adults. Proc. Nat. Acad. Sci., 93 (1993). 22. Henderson, R.A., & Finn, O.J. Human tumor...recovery T-cell responses to an influenza virus vac- examined whether stress influences cel- (2). The negative psychologic responses cine (10),. and

  8. Neurotoxin Binding Site on the Acetylcholine Receptor

    DTIC Science & Technology

    1987-03-01

    8794. 40. Neumann,D., D. Barchan , A. Safran, J.M. Gershoni, and S. Fuchs (1986) Proc. Nat. Acad. Sci. USA 83:3008-3011. 41. Juillerat, M.A., B... Barchan , M. Fridkin, and S. Fuchs (1986) Proc. Nat. Acad. Sci. USA 83:9250-9253. 57. Burl ey, S.K. and G.A. Petsko (19855’Science 229:23-28. 58 ;a

  9. A Bibliography of the Physical Equilibria and Related Properties of Some Cryogenic Systems

    DTIC Science & Technology

    1960-05-01

    Equations of state , general 7. Corresponding states 8. Beattie - Bridgeman 9. Benedict - Webb - Rubin 10. Potential forms, general 11. Virial...of State for Fluids Proc. Am. Acad. Arts and Sci. 63, 229-308 (1928) 44. Beattie , J. A., and Bridgeman , 0. C.; A New Equation of State for Fluids. II...the Constants of the Beattie - Bridgeman Equation of State Proc. Am. Acad. Arts and Sci. 64, 127-76 (1930) 47. Beattie

  10. Geomorphology and anthropogenic impact including military constraints in a microtidal wave-dominated embayment in south western Sardinia (Porto Pino beach, SCI ITB040025, Mediterranean Sea). Implications for beach management.

    NASA Astrophysics Data System (ADS)

    De Muro, Sandro; Buosi, Carla; Pusceddu, Nicola; Frongia, Paolo; Passarella, Marinella; Ibba, Angelo

    2016-04-01

    The coastal zones of the Mediterranean have undergone increasing pressure over the last century. The intensifying coastal development and the increasing tourist impact have led to an intense transformation of the coastlines and adjacent marine areas. The beach and the coastal dune play an important role in protecting the coastline. Thus, the study of its geomorphological evolution and of its anthropic modification is fundamental in order to adopt the best management practices. In this regard, the LIFE Project (LIFE13NAT/IT/001013) SOSS DUNES (Safeguard and management Of South-western Sardinian Dunes) aims to safeguard the dune habitats and the beach system in a site belonging to the Natura 2000 network, an EUwide network of nature protection areas established under the 1992 Habitats Directive. This project is focused on a microtidal wave-dominated embayment located in south western Sardinia (Italy, Mediterranean Sea) called Porto Pino beach comprised in the SCI (Site of Community Importance) "Promontory, dunes and wetland of Porto Pino (ITB040025)". This research aims to investigate the geomorphological processes, the evolution and the main human impacts on Porto Pino beach as an useful tool for both conservation and coastal management. The coastal area of Porto Pino is represented by sandy shorelines extending for a total length of 5 km characterized by a wide primary and secondary dune systems, a backshore wetland lagoon and marsh area arranged parallel to the coastline. This littoral area can be ideally divided into three parts: the first, about 600 m long, in the north-west part characterized by the highest human pressure due to touristic activity on the foredunes and deposition of beach wrack; the second part in the south-east, about 1100 m long, characterized by a complex dune system (primary and secondary foredunes); and the third southernmost part included in a military area, about 3300 m long, characterized by transgressive dune system with low human

  11. Structure and Characterization of Nicotinic Acetylcholine Receptors from Peripheral and Central Nervous Systems.

    DTIC Science & Technology

    1991-11-07

    Barchan , D., Safran, A., Gershoni, J. M. & Fuchs, S. (1986a) Proc. Natl. Acad. Sci. USA 83:3008-3011. Nomoto, H., Takahashi, N., Nagaki, Y., Endo, S...690-694. Neumann, D., Barchan , D., Safran, A., Gershoni, JI M., & Fuchs, S. (1986a) Proc. Natl. Acad. Sci. U.S.A. 83, 3008-3011. Neumann, D., Barchan , D...Fridkin, M., & Fuchs, S. (1986b) Proc. Natl. A cad. Sci. U.S.A. 83, 9250-9253. Neumann, D., Barchan , D., Horowitz, M., Kochva, E., & Fuchs, S

  12. Sci-Tech Feature: Plutonium. Fuel for Controversy.

    ERIC Educational Resources Information Center

    Iikubo, Ryuko

    1993-01-01

    Despite opposition by environmental organizations, Japan plans to import plutonium from France and Great Britain. Interviews Toichi Sakata, director of the nuclear fuel division of the Science and Technology Agency, who explains why Japan needs the radioactive substance. (MDH)

  13. Final report for Utah State's SciDAC CEMM contribution

    SciTech Connect

    Dr. Eric Held

    2008-05-13

    This document represents a summary of work carried out at Utah State University in conjunction with the Center for Extended Magnetohyrodynamic Modeling (CEMM). The principal investigator, Dr. Eric Held, was aided in this work by two former graduate students, Drs. John James and Michael Addae-Kagyah, who completed their PhD's while being partially funded by CEMM monies. In addtion, Dr. Jeong-Young Ji, a postdoctoral researcher and Mukta Sharma, a graduate student were supported. The work associated with this grant focused on developing an efficient, hybrid fluid/kinetic model for fusion plasmas. Specifically, expressions for the parallel heat fluxes and stresses in magnetized plasmas were implemented and exercised in the NIMROD plasma fluid code.

  14. Falling for sport: a case report of skydiving and SCI.

    PubMed

    Esser, Stephan M; Baima, Jennifer; Hirschberg, Ronald

    2013-01-01

    Participation in extreme sports has increased over the last 25 years. Although spinal cord injury may be sustained during extreme and traditional sports alike, the associated risk, location, and severity of injury varies by sport. We describe the case of a 31-year-old man who sustained an L1 burst fracture while landing his inaugural skydiving jump. He developed a mixed pattern of neurologic injury with relative preservation of lower extremity strength and impaired bowel and bladder function. Sports medicine providers should be aware of the risks associated with air sports/extreme sports participation. Such awareness may help prevent injury and enhance the management of associated complications.

  15. What Are the Treatments for Spinal Cord Injury (SCI)?

    MedlinePlus

    ... transport the patient to the hospital In the Emergency Room Once the patient is at the hospital, ... for communication Occupational therapy focused on fine motor skills Techniques for self-grooming and bladder and bowel ...

  16. An Implantable Neuroprosthetic Device to Normalize Bladder Function after SCI

    DTIC Science & Technology

    2012-10-01

    alternating Page 26 19 current on axonal conduction through the vagus nerve ,” J. Neural Eng., vol.8, 056031, 2011. [3] C. Tai, J.R. Roppolo, W.C. de...Wattaja, J.J., Tweden, K.S., Honda, C.N. (2011). Effects of high frequency alternating current on axonal conduction through the vagus nerve . Journal of...design the novel neuroprosthetic device. Based on our previous studies, we propose in this project to use pudendal nerve stimulation and blockade to

  17. An Implantable Neuroprosthetic Device to Normalize Bladder Function after SCI

    DTIC Science & Technology

    2013-10-01

    high frequency blocking stimulation has also been verified by recent clinical studies to block the vagus nerve for diabetes treatment. 12,13 The...alternating current on axonal conduction through the vagus nerve . J Neural Eng 2011; 8:056013. FIGURE CAPTIONS Fig.1. The implantable stimulator (A...on our previous studies, we propose in this project to use pudendal nerve stimulation and blockade to restore both continence and micturition after

  18. Molecular Determinants Fundamental to Axon Regeneration After SCI

    DTIC Science & Technology

    2011-01-01

    Months 1-18) Introduction: The zebrafish spinal cord model system is unique because of the co-existence of brainstem neurons that do ( regenerators ) and...3: To identify genes involved in axon regeneration from brainstem neurons in the injured adult zebrafish spinal cord. Experiments will be...performed to label brainstem neurons with fast blue that do or do not, regenerate an axon across an injury in the adult zebrafish spinal cord. Non

  19. Molecular Determinants Fundamental to Axon Regeneration After SCI

    DTIC Science & Technology

    2010-07-01

    1-12) Introduction: The zebrafish spinal cord model system is unique because of the co-existence of brainstem neurons that do ( regenerators ) and...11 SOW: Specifc Aim 3: To identify genes involved in axon regeneration from brainstem neurons in the injured adult zebrafish spinal cord...Experiments will be performed to label brainstem neurons with fast blue that do or do not, regenerate an axon across an injury in the adult zebrafish

  20. Molecular Determinants Fundamental to Axon Regeneration after SCI

    DTIC Science & Technology

    2012-06-01

    will determine the relationship between L1.1 and neurocan and its role in axon regeneration from adult zebrafish brainstem neurons in vitro. The...determine the relationship between L1.1 and neurocan and its role in axon regeneration from adult zebrafish brainstem neurons in vitro. Increased...concerning the potential interactions between neurocan and L1 and the role they play in axonal regeneration seen in the zebrafish . 18 Figure

  1. CitSci.org: Multi-Scale Citizen Science Support

    NASA Astrophysics Data System (ADS)

    Newman, G. J.; Crall, A.; Graham, J.; Laituri, M.

    2011-12-01

    Citizen science and community-based monitoring programs are increasing in number and breadth, generating volumes of scientific data. Many programs are ill-equipped to effectively manage these data. We examined the art and science of multi-scale citizen science support, focusing on issues of integration and flexibility that arise when programs span multiple spatial, temporal, and social scales across many domains. Our objectives were to: (1) review existing citizen science approaches and data management needs; (2) develop a cyber-infrastructure to support citizen science program needs; and (3) describe lessons learned. We find that approaches differ in scope, scale, and activities and that citizen science programs need best practices for data collection, standardization, integration and analysis. We built a multi-scale cyber-infrastructure support system for citizen science programs (www.citsci.org) and show that carefully designed systems can support individual program requirements while promoting interoperability necessary for cross-program meta-analyses. The system allows users with different levels of permission to themselves easily customize features and attributes they wish to collect, while adhering to a growing user-contributed, yet vetted, set of attributes necessary for cross-discipline comparisons and meta-analyses. Program evaluation integrated into the cyber-infrastructure will improve our ability to track effectiveness. We discuss the importance of standards for interoperability and the challenges associated with system maintenance and long-term support and conclude by offering a vision of the future of citizen science data management and cyber-infrastructure support.

  2. Try Sci Fi for Reading That's Out of This World!

    ERIC Educational Resources Information Center

    Bell, Robert; Zjawin, Dorothy

    1983-01-01

    Teachers can capitalize on children's interest in recent science fiction movies by using books based on the films in their classrooms. Books taken from "E. T.,""Star Wars,""The Empire Strikes Back," and "The Wrath of Khan" are summarized, and learning activities to be used in conjunction with the books are suggested. (PP)

  3. Q&A: The sci-fi optimist

    NASA Astrophysics Data System (ADS)

    Merali, Zeeya

    2014-09-01

    Best-selling science-fiction writer Neal Stephenson's works cover everything from cryptography to Sumerian mythology. Ahead of next year's novel Seveneves, he talks about his influences, the stagnation in material technologies, and Hieroglyph, the forthcoming science-fiction anthology that he kick-started to stimulate the next generation of engineers.

  4. NASA SCI Files - The Case of The Zany Animal Antics

    NASA Video Gallery

    This video covers the animal kingdom, how animals are classified, their basic needs, the food chain, reproduction and why animals migrate. Also learn about animal populations and habitats, endanger...

  5. SciDAC - Center for Plasma Edge Simulation - Project Summary

    SciTech Connect

    Parker, Scott

    2014-11-03

    Final Technical Report: Center for Plasma Edge Simulation (CPES) Principal Investigator: Scott Parker, University of Colorado, Boulder Description/Abstract First-principle simulations of edge pedestal micro-turbulence are performed with the global gyrokinetic turbulence code GEM for both low and high confinement tokamak plasmas. The high confinement plasmas show a larger growth rate, but nonlinearly a lower particle and heat flux. Numerical profiles are obtained from the XGC0 neoclassical code. XGC0/GEM code coupling is implemented under the EFFIS (“End-to-end Framework for Fusion Integrated Simulation”) framework. Investigations are underway to clearly identify the micro-instabilities in the edge pedestal using global and flux-tube gyrokinetic simulation with realistic experimental high confinement profiles. We use both experimental profiles and those obtained using the EFFIS XGC0/GEM coupled code framework. We find there are three types of instabilities at the edge: a low-n, high frequency electron mode, a high-n, low frequency ion mode, and possibly an ion mode like kinetic ballooning mode (KBM). Investigations are under way for the effects of the radial electric field. Finally, we have been investigating how plasmas dominated by ion-temperature gradient (ITG) driven turbulence, how cold Deuterium and Tritium ions near the edge will naturally pinch radially inward towards the core. We call this mechanism “natural fueling.” It is due to the quasi-neutral heat flux dominated nature of the turbulence and still applies when trapped and passing kinetic electron effects are included. To understand this mechanism, examine the situation where the electrons are adiabatic, and there is an ion heat flux. In such a case, lower energy particles move inward and higher energy particles move outward. If a trace amount of cold particles are added, they will move inward.

  6. SciDAC Visualization and Analytics Center for Enabling Technologies

    SciTech Connect

    Joy, Kenneth I.

    2014-09-14

    This project focuses on leveraging scientific visualization and analytics software technology as an enabling technology for increasing scientific productivity and insight. Advances in computational technology have resulted in an "information big bang," which in turn has created a significant data understanding challenge. This challenge is widely acknowledged to be one of the primary bottlenecks in contemporary science. The vision for our Center is to respond directly to that challenge by adapting, extending, creating when necessary and deploying visualization and data understanding technologies for our science stakeholders. Using an organizational model as a Visualization and Analytics Center for Enabling Technologies (VACET), we are well positioned to be responsive to the needs of a diverse set of scientific stakeholders in a coordinated fashion using a range of visualization, mathematics, statistics, computer and computational science and data management technologies.

  7. Sci-Fi, Storytelling, and New-Media Literacy

    ERIC Educational Resources Information Center

    Subramaniam, Mega; Ahn, June; Waugh, Amanda; Druin, Allison

    2012-01-01

    Understanding how to better engage young students in science, technology, engineering, and math (STEM) is essential. The constraints of U.S. K-12 schools (e.g. insufficient institutional supports, lack of technology access, testing pressures, etc.) often make it difficult to create truly engaging STEM curricula with which students can deeply…

  8. Restoring Bladder Function by Spinal Cord Neuromodulation in SCI

    DTIC Science & Technology

    2015-10-01

    Doc/0/6AJR79U394LKPCNU2NDHOP0LE4/fromString.html 17/47 Social  Security Number Medical Record Number Health Plan Numbers Account Numbers License...4.1 If  social  security numbers will be collected explain why they are necessary, how they will be used, how they will be protected and how long they...will be retained. Social  Security Numbers are used for reimbursement. They will be protected by being kept in a locked file cabinet in a lockedroom

  9. Treatment of Neuropathic Pain after SCI with a Catalytic Oxidoreductant

    DTIC Science & Technology

    2015-10-01

    chronic morphine tolerance in a mouse model under conditions previously reported for earlier analogs MnTE(or nHex)-2-PyP5+ ([21] [Warner et al...Batinic‐Haberle, I. Pharmacokinetics, Brain  Hippocampus  and Cortex, and  Mitochondrial Accumulation of a New Generation of Lipophilic Redox‐Active...parameter that dominates the efficacy of metalloporphyrins in blocking the  development of  morphine  antinociceptive tolerance through peroxynitrite‐mediated

  10. Treatment of Neuropathic Pain after SCI with a Catalytic Oxidoreductant

    DTIC Science & Technology

    2014-10-01

    shown the potency of MnTnBuoE-2-PyP5+ in suppressing chronic morphine tolerance in a mouse model under conditions previously reported for earlier...Rajic, Z.; Warner, D. S.;  Clair, D. K.; Huang, T. T.; Batinic‐Haberle, I. Pharmacokinetics, Brain  Hippocampus  and Cortex, and  Mitochondrial...Salvemini, D.  Lipophilicity is a critical parameter that dominates the efficacy of metalloporphyrins in blocking the  development of  morphine

  11. Molecular Determinants Fundamental to Axon Regeneration after SCI

    DTIC Science & Technology

    2014-09-01

    Figure 10. Zebrafish Spinal cord transection. Isolated spinal column of transected zebrafish spinal cord (rostral to left), panel A. Arrows...mammalian spinal cord, axon regeneration is frustrated by inhibitors such as chondroitin sulfate proteoglycans (CSPGs) expressed by reactive astrocytes...present at the injury site. In adult zebrafish, Danio rerio, some brainstem neuronsare able to grow their axon beyond a spinal cord injury, even

  12. SciDAC Center for Plasma Edge Simulation

    SciTech Connect

    Lin, Zhihong

    2013-12-17

    This project with a total funding of $592,998 for six years has partially supported four postdoctoral researchers at the University of California, Irvine (UCI). The UCI team has formulated electrostatic and electromagnetic global gyrokinetic particle simulation models with kinetic electrons, implemented these models in the edge code XGC1, performed benchmark between GTC and XGC1, developed computational tools for gyrokinetic particle simulation in tokamak edge geometry, and initiated preparatory study of edge turbulence using GTC code. The research results has been published in 12 papers and presented at many international and national conferences.

  13. Molecular Determinants Fundamental to Axon Regeneration after SCI

    DTIC Science & Technology

    2012-10-01

    swimming ) recovery will be assessed through analysis of a number of parameters related to swimming behavior. Functional recovery will be correlated...small piece of Gelfoam containing either PTPσ morpholino or control morpholino will be placed in the transection site. Functional ( swimming ... swimming ) recovery analysis will be performed. We have established a low-cost video tracking system that utilizes a video camera and computer monitor to

  14. SciDAC-Center for Plasma Edge Simulation Report

    SciTech Connect

    Parker, Steven

    2013-12-24

    The Common Component Architecture (CCA) effort is the embodiment of a long-range program of research and development into the formulation, roles, and use of component technologies in high-performance scientific computing. CCA components can interoperate with other components in a variety of frameworks, including SCIRun2 from the University of Utah. The SCIRun2 framework is also developing the ability to connect components from a variety of different models through a mechanism called meta-components. The meta component model operates by providing a plugin architecture for component models. Abstract components are manipulated and managed by the SCIRun2 framework, while concrete component models perform the actual work and communicate with each other directly. We will leverage the SCIRun2 framework and the Kepler system to orchestrate components in the Fusion Simulation Project (FSP) and to provide a CCA-based interface with Kepler. The groundwork for this functionality is being performed with the Scientific Data Management center. The SDM center is developing CCA-compliant interfaces for expressing and executing workflows and create workflow components based on SCIRun and Ptolemy (Kepler) execution engines, including development of uniform interfaces for selecting, starting, and monitoring scientific workflows. Accomplishments include Introduction to CCA and Simulation Software Systems, Introduction into SCIRun2 and Bridging within SCIRun2, CCALoop: A scalable design for a distributed component framework, and Combining Workflow methodologies with Component Architectures.

  15. End-User Training for Sci-Tech Databases.

    ERIC Educational Resources Information Center

    Mount, Ellis, Ed.

    1989-01-01

    Issues related to end-user training for scientific and technical online databases are discussed in five articles. Topics covered include instruction in the use of controlled and natural language vocabularies; a planning assessment for end-user searching; the role of the information center in industrial research; training for health care…

  16. Fitness and Independence after SCI: Defining Meaningful Change and Thresholds

    DTIC Science & Technology

    2015-10-01

    PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. 1. REPORT DATE October 2015 2. REPORT TYPE Annual 3. DATES COVERED 29 Sep 2014 - 28 Sep...Coordinate with Sites for annual IRB** report for continuing review Key Outcomes:  Local IRB approval at UM, NRH, GMU achieved  HRPO approval for...possible? 7. If we could provide a report that described how your fitness level is affecting your ability to perform daily activities in a manner that

  17. Calculation of Protein Heat Capacity from Replica-Exchange Molecular Dynamics Simulations with Different Implicit Solvent Models

    DTIC Science & Technology

    2008-10-30

    definition and calculation of the Born radii. To evaluate the Born radii, two approximations are invoked. The first is the Coulomb field approximation (CFA...energy term, and depending on the particular GB formulation, higher-order non- Coulomb correction terms may be added to the Born radii to account for the...Proc. Natl. Acad. Sci. U.S.A. 2003, 100, 7587. (22) Lei , H.; Wu, C.; Liu, H.; Duan, Y. Proc. Natl. Acad. Sci. U.S.A. 2007, 104, 4925. (23) Martinez, J

  18. Targetable Polymer - Antiangiogenic Drug Conjugates for Systemic Breast Cancer Therapy

    DTIC Science & Technology

    2005-09-01

    1.7FL G-Fu_ Legends: HPMA= N-(2-hydroxypropyl) methacrylamide, G=Glycine, F=Phenylalanine, L= Leucine , Fu=Fumagillol, M,=weight average molecular...CM. The anti-angiogenic agent fumagillin covalently binds and inhibits the methionine aminopeptidase , MetAP-2. Proc NatlAcad Sci USA. 1997; 94(12...covalently modifies a conserved active-site histidine in the Escherichia coli methionine aminopeptidase . Proc Natl Acad Sci USA. 1998; 95(21): 12153-7

  19. A simplified method for extracting androgens from avian egg yolks.

    PubMed

    Kozlowski, Corinne P; Bauman, Joan E; Hahn, D Caldwell

    2009-03-01

    Female birds deposit significant amounts of steroid hormones into the yolks of their eggs. Studies have demonstrated that these hormones, particularly androgens, affect nestling growth and development. In order to measure androgen concentrations in avian egg yolks, most authors follow the extraction methods outlined by Schwabl (1993. Proc. Nat. Acad. Sci. USA 90:11446-11450). We describe a simplified method for extracting androgens from avian egg yolks. Our method, which has been validated through recovery and linearity experiments, consists of a single ethanol precipitation that produces substantially higher recoveries than those reported by Schwabl (1993. Proc. Nat. Acad. Sci. USA 90:11446-11450). Zoo Biol 28:137-143, 2009.

  20. Biology of Immunomodulators

    DTIC Science & Technology

    1987-07-01

    Acad. Sci. 75:4194, 1978. 10. Fidler, I.J., Raz, A., Fogler , W.E., Kirsh, R., Bugelski, P. and Poste, G. Cancer Res. 40:4460, 1980. 11. Fidler, I.J...Barnes, Z., Fogler , W.E., Kirsh, R., Bugelski, P. and Poste, G. Cancer Res. 42:496, 1982. 12. Rahman, Y.E., Cerny, E.A., Patel, D.R., Lau, E.H. and...Agents and Chemo. 27:903, 1985. 18. Fidler, I.J., Sone, S., Fogler , W.E. and Barnes, Z.L. Proc. Natl. Acad. Sci. USA 78:1680, 1981. 19. Sone, D. and Fidler

  1. Biology of Immunomodulators

    DTIC Science & Technology

    1988-07-01

    and Papahadjopoulos, D. Proc. Natl. Acad. Sci. 75:4194, 1978. 10. Fidler, I.J., Raz, A., Fogler , W.E., Kirsh, R., Bugelski, P. and Poste, G. Cancer Res...40:4460, 1980. 11. Fidler, I.J., Barnes, Z., Fogler , W.E., Kirsh, R.’, Bugelski, P. and Poste, G. Cancer Res. 42:496, 1982. 12. Rahman, Y.E., Cerny...G.M. and Canonico, P. Antimicrob. Agents and Chemo. 27:903, 1985. 18. Fidler, I.J., Sone, S., Fogler , W.E. and Barnes, Z.L. Proc. Natl. Acad. Sci. USA

  2. The Role of XMRV, a Novel Xenotropic Murine Retrovirus, in Human Prostate Cancers

    DTIC Science & Technology

    2011-05-01

    antiviral pathway from human prostate tumors. Proc Natl Acad Sci U S A 104:1655-60. 2. Dunn, G.P., K.C. Sheehan , L.J. Old, and R.D. Schreiber. 2005. IFN...sequences in blood of patients with chronic fatigue syndrome and healthy blood donors. Proc Natl Acad Sci U S A 5. Lombardi, V.C., F.W. Ruscetti...The views, opinions and/or findings contained in this report are those of the author( s ) and should not be construed as an official Department of

  3. Novel Interphases: Synthesis, Molecular Orientation and Grafting of Liquid Crystal Polymers on Carbon Fibers

    DTIC Science & Technology

    1990-01-01

    rigid molecules into an anisotropic phase have been reported. Lars Onsager (13) showed that steric interactions between rigid rods can lead to...will eventually undergo an Onsager orientational transition. From a properties point of view the occurrence of a high density surface layer with...Plate’, N. A., Adv. in Polym. Sci., 1984, 173. (12) Flory, P. J., Proc. Royal Soc. London, 1956, A234, 73. (13) Onsager , L., Ann. N. Y. Acad. Sci

  4. Prevention of the Angiogenic Switch in Human Breast Cancer

    DTIC Science & Technology

    2008-03-01

    contains a tumour. Thalidomide has a slightly higher incidence of thromboembolic complica- tions, as well as constipation and peripheral neuropathy ...through direct and indirect angiogenesis inhibition. Proc Natl Acad Sci USA ; 2008; 105(3):985-990. 7 Kang, S.Y., Halvorsen, O.J., Lee, J.M., Liu, N.W...Sci USA ; 2008; 105(3):985-990. 10 The term angiogenesis is generally applied to the growth of microvessel sprouts the size of

  5. Estimating maximum global wind power availability and associated climatic consequences

    NASA Astrophysics Data System (ADS)

    Miller, Lee; Gans, Fabian; Kleidon, Axel

    2010-05-01

    Natl Acad Sci, 106. [3] Liu, W.T., W. Tang, and X. Xie, (2008) Wind power distribution over the ocean, Geophys. Res. Lett., 35 L13808. [4] IPCC, (2008) IPCC scoping meeting on renewable energy sources - proceedings, Intergovernmental Panel on Climate Change [5] U.S. Department of Energy, (2008) 20% wind energy by 2030: increasing wind energy's contribution to U.S. electricity supply, U.S. Dept. of Energy - Energy Information Administration. [6] EEA, (2009) Europe's onshore and offshore wind energy potential, European Environment Agency, ISSN 1725-2237.

  6. Effect of EEG Biofeedback on Convulsive Response to Monomethylhydrazine in the Rhesus Monkey

    DTIC Science & Technology

    1978-06-01

    responses, AMRL-TR-67-67 (AD 663764), Aerospace Medical Research Laboratory, Wright-Patterson Air Force Base, Ohio. Kaplan, Bonnie J., 1975...Acad. of Sci. 157: 723-739. Wyler, A. R., Lockard , J. S., Ward, A. A. and Finch, C. A., 1976, Conditioned EEG desynchronization and seizure

  7. The Effect of Plastic Deformation on the Transport of Hydrogen in Nickel

    DTIC Science & Technology

    1979-09-01

    dragged by mobile dislocations. This was first suggested by Bastien and Azou (2,3). Later, this concept has been supported by observa- 11 F tions of...Institute (1973). 2. P. BastienandP. Azou , C.R. Acad. Sci. Paris, 21?, 1845 (1951). 3. P. Bastien and P. Azou , Proc. 1st World Metailurgical Congress, 535

  8. The Role of Grain Boundary Chemistry and the Environment on Intergranular Fracture.

    DTIC Science & Technology

    1980-10-01

    dragged by mobile dislocations. This was first suggested by Bastien and Azou (38, 39). Later, this concept was supported by observations of serrated...P. Azou : C. R. Acad. Sci. Paris, 1951, vol. 232, p. 1845 39. P. Bastien and P. Azou : Proc. ist World Metallurgical Congress, p. 535, ASM, Cleveland

  9. Hydrogen Induced Intergranular Cracking of Nickel-Base Alloys.

    DTIC Science & Technology

    1982-02-01

    locations as being an important step in the embrittle- ment mechanism. It was first suggested by Bastien and Azou (1) that mobile dislocations carry...W-7405-ENG-48 and the Office of Naval Research under contract number N00014-78-C-0002/NR 036-127. References 1. P. Bastien and P. Azou , C.R. Acad. Sci

  10. Advanced Sensors for TBI

    DTIC Science & Technology

    2011-07-01

    degrees C) in temperature within the biological range of 34-45 degrees C (Figure 14). REPORTABLE OUTCOMES: Lyeth B., Bonner D., Van K ...seizures, fever, and neurotrauma. Ann N Y Acad Sci. 1113:173-177. Bauman, R.A., Ling, G., Tong, L., Januszkiewicz , A., Agoston, D., Delanerolle, N., Kim

  11. Neck Fatigue and Comfort Effects Due to the Extended Wear of Law Enforcement Representative Head-Borne Personal Protective Equipment

    DTIC Science & Technology

    2010-12-01

    Moments of the Component Masses of the Human Body" Trans, of the Math-Phys., Royal Bavarian Acad. of Sci., 8(1), 69-96. Unpublished English Translation...please explain: 6. Are you using any bandages, moleskin, petroleum jelly , or powders on your feet? Yes No If Yes, please explain: 7. Do you

  12. A Fast and Accurate Algorithm for l1 Minimization Problems in Compressive Sampling (Preprint)

    DTIC Science & Technology

    2013-01-22

    performance of algorithms in terms of various error metrics, speed, and robustness to noise. All the experiments are performed in Matlab 7.11 on...online version available, (2011). [17] J.-J. Moreau, Fonctions convexes duales et points proximaux dans un espace hilbertien, C.R. Acad. Sci. Paris Sér

  13. Structure and Expression of Genes for Flavivirus Immunogens.

    DTIC Science & Technology

    1985-09-01

    RNA:DNA hybrid (ReVchoudhurv, et al., 1980). All cDNA preparations were introduced into the plasmid vector pBR322 ( Covarrubias et al., 1981) through the...Yabrov, R., Bittle, J., Hogle, J. and Baltimore, D. (1985) Proc. Natl. Acad. Sci., U.S.A. 82, 910. Covarrubias , L., Cervantes, L., Covarrubias , A

  14. Jagged-1 Signaling Pathway in Prostate Cancer Cell Growth and Angiogenesis

    DTIC Science & Technology

    2009-04-01

    intracellular domain and Jagged-1 cDNA plasmid were the kind gifts of L. Miele {Department of Biopharmaceutical Sciences and Cancer Center...rtavanis-Tsakonas,S. Alterations in Notch signaling in neoplastic lesions of the human cervix, Proc.Natl.Acad.Sci.U.S.A, 92: 6414-6418, 1995. 7 Miele

  15. Lipoxygenase, Angiogenicity, and Prostate Cancer Radioresistance

    DTIC Science & Technology

    2007-01-01

    N.). The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked ...Whang, Y. E., and Sawyers, C. L. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 15587–15591 42. McMenamin , M. E., Soung, P., Perera, S., Kaplan, I., Loda

  16. How Gender and Reformed Introductory Physics Impacts Student Success in Advanced Physics Courses and Continuation in the Physics Major

    ERIC Educational Resources Information Center

    Rodriguez, Idaykis; Potvin, Geoff; Kramer, Laird H.

    2016-01-01

    Active-learning approaches to teaching introductory physics have been found to improve student learning and affective gains on short-term outcomes [S. Freeman et al., "Proc. Natl. Acad. Sci. U.S.A. 111," 8410 (2014)]; however, whether or not the benefits of active learning impact women to the same degree as men has been a point of…

  17. Lapses in Alertness: Coherence of Fluctuations in Performance and EEG Spectrum

    DTIC Science & Technology

    1993-01-01

    panels. the regression equations derivcd to fit the Terzano and Parrino lh&: Pastclak-Price et al. 1 990)). first sessions were used to predict error rates...time. Ann. NY 1991: 57P. Acad. Sci., 1966, 138: 623-631. PERFORMANCE FLUCTUATIONS AND EEG SPECTRUM 35 Terzano. M.G. anti Parrino , L. The cyclic

  18. Development of a Nanotechnology Platform for Prostate Cancer Gene Therapy

    DTIC Science & Technology

    2011-07-01

    to Bedside: Tom Redelmeier of Northern Lipids Inc., David Owen of Starpharma, Derek O’Hagan of Novartis, Sonke Svenson of Cerulean Pharma Inc...K. Altendorf, Bafilomycins: a class of inhibitors of membrane ATPases from microorganisms, animal cells, and plant cells, Proc. Natl. Acad. Sci. U

  19. Genetics Home Reference: pseudohypoaldosteronism type 1

    MedlinePlus

    ... hyperkalaemic acidosis, pseudohypoaldosteronism type 1. Nat Genet. 1996 Mar;12(3):248-53. Citation on PubMed Chen ... sgk. Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):2514-9. Citation on PubMed ...

  20. Loss of PTEN as a Predictive Biomarker of Response to Lithium Chloride, A Potential Targeted Treatment for Breast Cancer

    DTIC Science & Technology

    2013-11-01

    Acad Sci USA 2007; 104:7564-9. 11. Carpten JD, Faber AL, Horn C, Donoho GP, Briggs SL, Robbins CM, et al. A transforming mutation in the pleckstrin...commercial research grant for Genentech Incorporation and is a consultant/advisory board member for Genentech Incorporation, Bristol Myers Squibb, and

  1. Mechanism of Ovarian Epithelial Tumor Predispostion in Individuals Carrying Germline BRCA1 Mutations

    DTIC Science & Technology

    2005-01-01

    are predisposed to ovarian cancer is that the ensuing decrease in BRCA1 gene dosage results in a disruption of normal cellular interactions between...Bioactivation of Mullerian inhibiting substance during gonadal development by a kex2/ subtilisin -like endoprotease. Proc. Natl. Acad. Sci. 93, 7711

  2. Engineering Bony Hybrid Organs In Vitro

    DTIC Science & Technology

    2006-11-01

    microfluidic cell culture system using elastomeric channels and Braille displays (Gu et al., 2004; Futai et al., 2004). We have now further developed this...Takayama S, 2004: Computerized microfluidic cell culture using elastomeric channels and braille displays. Proc. Natl. Acad. Sci. USA 101, 15861-15866

  3. To Measure and Characterize Metal Corrosion in Electrolyte Solutions by Exploiting the Properties of Superconducting

    DTIC Science & Technology

    1988-08-30

    electrochemical reactions. Investigation of BeSO 4 ( 3 1), KC1, butyric acid, isobutyric acid aqueous solutions( 3 2) have detected conductivity fluctuations with...Langevin, P., C. R. Acad. Sci. Paris , 141, 530 (1908) 18) Uhlenbeck, G. E., and Ornstein, L. S., Phys. Rev., 3, 823 (1930) 165 19) Tyagai, V. A., and

  4. Decreased Migration of Langerhans Precursor-Like Cells in Response to Human Keratinocytes Expressing HPV-16 E6/E7 is Related to Reduced Macrophage Inflammatory Protein-3Alpha Production

    DTIC Science & Technology

    2005-01-01

    infection. Introduction. Human papillomaviruses (HPVs) are small DNA viruses which exhibit tropism for cutaneous or mucosal epithelium. Commonly...retinoblastoma protein correlates with the transforming capacity of the E7 oncoproteins of the human papillomaviruses . Proc Natl Acad Sci U S A 89:4442-6

  5. Force-Free Magnetic Fields, Curl Eigenfunctions, and the Sphere in Transform Space, With Applications to Fluid Dynamics and Electromagnetic Theory

    DTIC Science & Technology

    1993-01-08

    recent work of Laurence and Avellaneda 3l’) were devoted to exploring the energy and stability of an FFMF by examining the behavior of a pseudoscalar...Variational Formulation. Proc National Acad. Sci. (USA), 45: 769-771. 39. Laurence, P., and Avellaneda , M. (1991) On Woltjer’s variational principle for

  6. DNA Precursor Metabolism and Mitochondrial Genome Stability

    DTIC Science & Technology

    2003-04-01

    mitochondrial thiamine pyrophosphate depletion, embryonic lethality, CNS malformations, and anemia. Proc. Natl. Acad. Sci. USA 103, 15927–15932. List of papers...to facilitate deoxyribonucleotide transport, with diphosphates being the preferred substrates. Biesecker’s laboratory had generated knockout mice...transport ribonucleotides in reconstituted liposomes, with diphosphates again being the preferred substrates. That led us to speculate that the

  7. Investigation of the Basis for Persistent Porin Serotypes of Neisseria Gonorrhoeae in Community Infections

    DTIC Science & Technology

    2006-01-01

    community outbreaks. N. gonorrhoeae has a number of highly phase variable surface structures, most notably, opacity (Opa) proteins, lipo- oligosaccharide ...Multilocus sequence typing: a portable approach to the identification of clones within populations of pathogenic microorganisms . Proc Natl Acad Sci U S

  8. Combining Chemoselective Ligation with Polyhistidine-Driven Self-Assembly for the Modular Display of Biomolecules on Quantum Dots

    DTIC Science & Technology

    2009-01-01

    Antimicrobial Resistance and the Viable but Nonculturable State in Human Pathogenic Vibrio spp. Proc. Natl. Acad. Sci. U.S.A. 2005, 102, 19109–19114. 26...Caspase-3 Is Enriched in Postsynaptic Densities and Increased in Alzheimer’s Disease. Am. J. Pathol. 2008, 173, 1488–1495. 34. Fischer , U.; Schulze-Osthoff

  9. Large Amplitude Ion Waves.

    DTIC Science & Technology

    1982-11-19

    p 488. 10. A. Sommerfeld, Gotting, Nachricht. U, 363 (1904). 11. E. Curie , Madame Curie (Heinemann, London 1941). 12. L. allett, C.R. Acad. Sci...observations of Cerenkov radiation. M. Curie in 1911 deduced that one component of radiation produced in the walls of a glass container containing

  10. Environmental Impact Research Program. Doveweeds (Croton supp.) Section 7.4.2, US Army Corps of Engineers Wildlife Resources Management Manual.

    DTIC Science & Technology

    1986-07-01

    1975. Flora of the Texas Coastal Bend. Welder Wildl. Found. Contrib. B-6. Mission Press, Corpus Christi, Tex. 262 pp. Korschgen, L. J. 1948. Late-fall...Illinois. Trans. Ill. Acad. Sci. 55:115-129. Radford, A. E., H. E. Ahles, and C. R. Bell. 1968. Manual of the Vascular Flora of the Carolinas. Univ. N.C

  11. Exploring the Interaction between TSC2, PTEN, and the NMDA Receptor in Animal Models of Tuberous Sclerosis

    DTIC Science & Technology

    2014-09-01

    Baker SJ (2003) mTor is required for hypertrophy of Pten-deficient neuronal soma in vivo. Proc Natl Acad Sci U S A 100:12923-12928. Kwon CH, Zhu X... hypertrophy in a mouse model of cortical dysplasia. Dis Model Mech 2:389-398. Mahimainathan L, Ghosh-Choudhury N, Venkatesan B, Das F, Mandal CC, Dey N

  12. New Organisational Structures and the Transformation of Academic Work

    ERIC Educational Resources Information Center

    Nyhagen, Gigliola Mathisen; Baschung, Lukas

    2013-01-01

    This article will particularly focus on Norway and the consequences for academic work. Frequently in studies of academic work, focus has been on academics' individual autonomy and to what extent the latter is challenged (Altbach in "Ann Am Acad Pol Soc Sci" 448:1-14, 1980; Shattock in "High Educ" 41:27-47, 2001). One of the…

  13. Multifactorial Assessment of Depleted Uranium Neurotoxicity

    DTIC Science & Technology

    2004-10-01

    Cytochem. 49(8), 1059-60. Portera-Cailliau C, Sung CH, Nathans J, Adler R. (1994) Apoptotic photoreceptor cell death in mouse models of retinitis ... pigmentosa . Proc Natl Acad Sci. 91(3), 974-8. Salminen WF Jr, Voellmy R, Roberts SM. (1997) Protection against hepatotoxicity by a single dose of

  14. 76 FR 61717 - Government-Owned Inventions; Availability for Licensing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-05

    ... HUMAN SERVICES National Institutes of Health Government-Owned Inventions; Availability for Licensing... function and immune complex-mediated granulocyte activation in human lymphatic filariasis. Am J Trop Med... human filarial parasite Brugia malayi and its endosymbiont Wolbachia. Proc Natl Acad Sci USA. 2011...

  15. PECAM-1 and Angiogenesis

    DTIC Science & Technology

    2009-12-01

    studies have shown that systemic delivery of an anti–PECAM-1 ribozyme suppresses the progression of already established tumor metastases (11). We...plasmid-based ribozyme targeting in adult mice. Proc Natl Acad Sci USA 99:3878–3883. 12. Vantyghem SA, Postenka CO, Chambers AF (2003) Estrous cycle

  16. Development of Aptamer Beacons for Antemortem Diagnosis of Chronic Wasting Disease

    DTIC Science & Technology

    2005-05-01

    binding aptamers." J Biol Chem 279(13): 13102-9. Schmerr, M. J., R. C. Cutlip, et al. (1998). "Capillary isoelectric focusing of the scrapie prion protein... scrapie ." Proc Natl Acad Sci U S A 83(16): 6146- 50. Wadsworth, J. D., S. Joiner, et al. (2001). "Tissue distribution of protease resistant prion

  17. Development and Validation of a Computational Model for Intra-Cellular Circadian Oscillators

    DTIC Science & Technology

    2005-05-01

    100: 14806- 14811 . Forger DB, Dean DA 2nd, Gurdziel K, Leloup JC, Lee C, Von Gall C, Etchegaray JP, Kronauer RE, Goldbeter A, Peskin CS, Jewett ME...Proc Natl Acad Sci U S A 100: 14806- 14811 . Forger DB, Dean DA 2nd, Gurdziel K, Leloup JC, Lee C, Von Gall C, Etchegaray JP, Kronauer RE, Goldbeter A

  18. Ennoblement Due to Biofilms: Indicator for Potential Corrosion and Source of Electrical Energy

    DTIC Science & Technology

    2013-01-01

    Several authors have demonstrated that microbiologically produced flavins, pyocyanin and phenazine enhance electron transfer in MFC [64-66...extracellular electron transfer. Proc Nat Acad Sci USA 2008; 105(10): 3969-73. [65] Rabaey K, Boon N, Hofte M, Verstraete W. Microbial phenazine

  19. Hsf1 in Her2-positive Breast Cancer

    DTIC Science & Technology

    2011-02-01

    CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT 18. NUMBER OF PAGES 19a. NAME OF RESPONSIBLE PERSON USAMRMC a. REPORT U b . ABSTRACT U c. THIS PAGE...induces metastatic disease. Proc Natl Acad Sci U S A. 1992 Nov 15;89(22):10578-82. 5. Muller WJ, Arteaga CL, Muthuswamy SK, Siegel PM, Webster MA

  20. Cellular Targets of Dietary Polyphenol Resveratrol

    DTIC Science & Technology

    2005-03-01

    corresponding mRNA from skin fibroblasts derived from Alzheimer disease patients. Proc Natl Acad Sci U S A 88: 5852. 8. Sporn, M. B., and Suh, N. 2002......Dietary Polyphenol Resveratrol 5b. GRANT NUMBER W81XWH-04-1-0059 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S

  1. Structural Characterization of the Putative Cholinergic Binding Region alpha(179-201) of the Nicotinic Acetylcholine Receptor. Part 1. Review and Experimental Design.

    DTIC Science & Technology

    1993-04-01

    alpha-subunit of the acetylcholine receptor. Proc. Natl. Acad. Sci USA, vol. 82, pp. 3490-3493, 1985 Neumann, D, Barchan , D., Safran, A., GershoniJ., and...pp. 3008-3011, 1986 MAY. Neumann, D., Barchan , D., Fuchs, S., Analysis of ligand binding to the synthetic dodeca-peptide 185-1% of the acetylcholine

  2. Guanidino Groups Greatly Enhance the Action of Antimicrobial Peptidomimetics Against Bacterial Cytoplasmic Membranes

    DTIC Science & Technology

    2014-05-28

    Chen, R.J. Doerksen, J. Kaplan, P.J. Carroll , M.L. Klein, W.F. DeGrado, De novo design of biomimetic antimicrobial polymers, Proc. Natl. Acad. Sci. U. S...J.J. Diaz-Mochon, L. Bialy, M. Bradley , Full orthogonality between Dde and Fmoc: the direct synthesis of PNA–peptide conjugates, Org. Lett. 6 (2004

  3. A Catalog of Solar White-Light Flares (1859-1982), Including Their Statistical Properties and Associated Emissions.

    DTIC Science & Technology

    1983-09-20

    d’eruption solaires en lumiere integrale , Orion 18:403. 9. Fritzova, L. , Kopecky, Al. , and Svestka, Z. (1958) Publ. Astron. Inst. Czech. Acad. Sci...protuberantielle au sein d’une tache solaire, L’Astronomie 36:276. 25. DuMartheray, M. (1948) Observations d’eruptions solaire en lumiere integrale

  4. Validation of Biomarkers Predictive of Recurrence Following Prostatectomy

    DTIC Science & Technology

    2011-04-14

    NM, Fernandes TF, Croce CM, Litwack G: Overexpressed full-length human BCL2 extends the survival of baculovirus-infected Sf9 insect cells, Proc Natl...the survival of baculovirus- infected Sf9 insect cells, Proc Natl Acad Sci U S A 1992, 89:7295-7299 58. Wagner AJ, Small MB, Hay N: Myc-mediated

  5. Genetic Analysis of the Nature of Genes Coding Early Enzymes in the Metabolism of Cresol in JPT3-4, a Derivative Strain of Pseudomonas Aeroginosis J1.

    DTIC Science & Technology

    1982-04-29

    sections, The cresols, phenol, and catechols were purchased from Aldrich. Crystalline catechols were vacuum- sublimated and stored in brown phials under...transmissible plasmid controlling camphor oxidation in Pseudomonas putida. Proc, Nat. Acad. Sci. U.S.A. 70:855-889. Ribbons, D, W. 1966, Metabolism of o

  6. Turnover of Acetylcholine Receptors: Mechanisms of Regulation

    DTIC Science & Technology

    1988-12-01

    ME, Whittingham S, and Duane DD (1976) Antibody to acetylcholine receptor in myasthenia gravis : prevalance, clinical correlates and diagnostic value...transferred to nitorcellulose. Proc Natl Acad Sci 77:5201-5205. Weinberg CB and Hall ZW (1979) Antibodies from patients with myasthenia gravis recognize

  7. Composition-spread Growth and the Robust Topological Surface State of Kondo Insulator SmB6 Thin Films

    DTIC Science & Technology

    2014-01-01

    of heterostructures for probing the long-sought Majorana fermions by coupling this material with a conventional superconductor 27 . In this...Natl. Acad. Sci. 111, 4798 (2014). 27. Fu, L. & Kane, C. L. Superconducting Proximity Effect and Majorana Fermions at the Surface of a

  8. Langevin Theory of Anomalous Brownian Motion Made Simple

    ERIC Educational Resources Information Center

    Tothova, Jana; Vasziova, Gabriela; Glod, Lukas; Lisy, Vladimir

    2011-01-01

    During the century from the publication of the work by Einstein (1905 "Ann. Phys." 17 549) Brownian motion has become an important paradigm in many fields of modern science. An essential impulse for the development of Brownian motion theory was given by the work of Langevin (1908 "C. R. Acad. Sci.", Paris 146 530), in which he proposed an…

  9. Relativistic Theory for Syntonization of Clocks in the Vicinity of the Earth

    DTIC Science & Technology

    1994-12-01

    uncertainty when using modern leveling techniques and gravimetry is below 0.5 mm/& ( Kasser 1989) and does therefore not exceed a few centimeters even... Kasser M., 1989, C. R. Acad. Sci. Paris, t. 309, Sdrie 11, p.695 Klioner S.A., 1992, Celestial Mechanics and Dynamical Astronomy 53, p.81 Kopejkin S.M

  10. OCCURRENCE AND ORIENTATION OF PARALICHTHID FLOUNDERS (BOTHIDAE: PARALICHTYS) ON AN INTERTIDAL BEACH

    EPA Science Inventory

    Middaugh, Douglas P. and Charles L. McKenney, Jr. 2003. Occurrence and Orientation of Flounders (Bothidae: Paralichthys) on an Intertidal Beach. J. North Carol. Acad. Sci. 119(4):157-171. (ERL,GB 1172).

    The intertidal movement and burying pattern of paralichthid flounders...

  11. A Novel Approach for Preventing HIV Infection and Reducing Risk to U.S. Military Personnel

    DTIC Science & Technology

    2013-09-01

    Kelly JW, Mothes W, Grivel JC, Margolis L, Keppler OT, Forssmann WG, Kirchhoff F. (2007) Semen-derived amyloid fibrils drastically enhance HIV...gallate counteracts semen- mediated enhancement of HIV infection. Proc Natl Acad Sci U S A 106:9033- 9038. 4. Roan NR, Munch J, Arhel N, Mothes W

  12. New Insights into the Hendra Virus Attachment and Entry Process from Structures of the Virus G Glycoprotein and Its Complex with Ephrin-B2

    DTIC Science & Technology

    2012-11-05

    and crystallized as described in [34]. Data collection and structure determination Crystals were cryo-protected in mother-liquor with 25% glycerol added...insight into effective vaccines . Proc Natl Acad Sci U S A. 40. Yuan P, Swanson KA, Leser GP, Paterson RG, Lamb RA, et al. (2011) Structure of the

  13. Using RNA Interference to Reveal Genetic Vulnerabilities in Human Cancer Cells

    DTIC Science & Technology

    2005-07-01

    Luo, B., Heard, A.D. & Lodish , H.F. Small interfering RNA production by enzymatic engineering of DNA (SPEED). Proc Natl Acad Sci U S A 101, 5494-9...suppressors identifies REST. Cell 121, 837-48 (2005). 44. Chen, C.Z., Li, L., Lodish , H.F. & Bartel, D.P. MicroRNAs modulate hematopoietic lineage

  14. Manipulating claudin expression in avian embryos.

    PubMed

    Collins, Michelle M; Ryan, Aimee K

    2011-01-01

    Since the discovery of Claudin-1 and -2 by Tsukita and colleagues in the late 1990s [Furuse et al. J Cell Biol 141:1539-50,1998], claudin family members have been found to have critical roles in maintaining the integrity of epithelial and endothelial tight junctions [Furuse and Moriwaki Ann N Y Acad Sci 1165:58-61, 2009; Morita et al. Proc Natl Acad Sci USA 96:511-6, 1999; Tsukita and Furuse Ann N Y Acad Sci 915:129-35, 2000; Turksen and Troy J Cell Sci 117:2435-47, 2004]. The properties of distinct claudin family members in tight junction permeability and specificity have been extensively studied in vitro using cell culture models. In vivo, claudin family members are dynamically regulated during embryogenesis and alterations in their expression patterns can have detrimental effects on the formation and physiological function of the tissues in which they are expressed. The chick embryo provides an excellent system to dissect the roles of specific family members in vivo and to explore the effects of modulating claudin expression during the epithelial-to-mesenchymal and mesenchymal-to-epithelial transitions that are associated with tissue morphogenesis and differentiation. We are using the chick embryo to understand the roles of the claudin family of tight junction proteins during gastrulation and left-right patterning during embryogenesis. Here, we describe methodologies for manipulating claudin gene expression in specific target tissues during chick embryogenesis.

  15. Teaching Astronomy Really Dynamically Involving Sci-Fi, or the Other TARDISTeaching Astronomy Really Dynamically Involving Sci-Fi, or the Other TARDIS

    NASA Astrophysics Data System (ADS)

    Larsen, K.

    2014-07-01

    Teaching science through science fiction films, series, and novels is not a new phenomenon; however, how many of us are still stuck using the original Star Trek (or even The Next Generation), Contact, and Deep Impact? These works often predate our current students' births by many years. Faculty members may still find them exciting and relevant, but we should periodically re-evaluate their relevance and effectiveness. In addition, there are works of popular culture in other genres, such as comedy and cartoons, that feature references to astronomical topics. A new generation of students should be taught through a new generation of media. This hands-on workshop introduced timely examples of popular culture that can be utilized to make astronomical concepts come alive in the introductory classroom, as well as methods for fishing for future examples as new media continues to be released.

  16. Response to V. A. Marichev's reply [Surf. Sci. 605(2011)2097] to the comments written by E. M. Gutman [Surf. Sci. 605(2011)1923

    NASA Astrophysics Data System (ADS)

    Gutman, Emmanuel M.

    2012-04-01

    For the first time, it is shown that the first and second Gokhshtein equations were originally derived by him from false fundamental equations violating criteria for applications of Maxwell relations and Legendre transforms. These equations are erroneous. For example, the direct connection between the electrode potential and charge density is actually independent of the tangential elastic strain of flat ideally polarizable electrode. The sequence of equations of Shuttleworth-Herring-Eriksson-Couchman-Jesser-Everet-Davidson-Rusanov has a common mathematical defect which consists of illegally equating the total differential to the partial differential.

  17. The Use of a Human Breast Tumor Progression Series and a 3-D Culture Model to Determine if Nuclear Structure Could Provide a Molecular and Therapeutic Marker

    DTIC Science & Technology

    2000-01-01

    beta-catenin. J Cell Biol 128:959-968. cadherin-binding protein plakoglobin. Proc Natl Acad Sci Gamallo C, Palacios J, Suarez A, Pizarro A, Navarro P...USA92:4522-4526. Quintanilla M, Cano A (1993): Correlation of E-cadherin Kartenbeck J, Schmid E, Franke WW, Geiger B (1982): expression with...catenin during axis speci- nuclear domains. J Cell Sci 110:239-247. fication inXenopus. J Cell Biol 139:229-243. Lallena M-J, Martinez C, Varcarcel J

  18. Synthesis and Small-Angle X-Ray Scattering Investigations of Ureido-Pyrimidone Hydrogen Bonding Star and Linear Poly(ethylene-co-propylene)s

    DTIC Science & Technology

    2006-02-01

    that are decorated N N O CH3 N O N N NO CH3 N O N H H H H H H 2 with the UPy moiety. Lange and coworkers demonstrated that end-functionalization...Kyogoku, Y.; Lord, R. C.; Rich, A. Proc. Natl. Acad. Sci. USA 1967, 57, 250–7. 6. Serge H. M.; Sijbesma, R. P.; van Genderen, H. P.; Meijer, E. W...J. Am. Chem. Soc. 2000, 122, 7487–7493. 7. Lange , R. F. M.; van Gurp, M.; Meijer, E. W. J. Polym. Sci. A: Polym. Chem. 1999, 37, 3657–3670. 8

  19. Testing General Relativity with Atomic Clocks

    NASA Astrophysics Data System (ADS)

    Reynaud, S.; Salomon, C.; Wolf, P.

    2009-12-01

    We discuss perspectives for new tests of general relativity which are based on recent technological developments as well as new ideas. We focus our attention on tests performed with atomic clocks and do not repeat arguments present in the other contributions to the present issue (Space Sci. Rev. 2009, This Issue). In particular, we present the scientific motivations of the space projects ACES (Salomon et al. in CR Acad. Sci. IV-2:1313, 2001) and SAGAS (Wolf et al. in Exp. Astron. 23:651, 2009).

  20. Reconciling disagreement over climate-conflict results in Africa.

    PubMed

    Hsiang, Solomon M; Meng, Kyle C

    2014-02-11

    A recent study by Burke et al. [Burke M, Miguel E, Satyanath S, Dykema J, Lobell D (2009) Proc Natl Acad Sci USA 106(49):20670-20674] reports statistical evidence that the likelihood of civil wars in African countries was elevated in hotter years. A following study by Buhaug [Buhaug H (2010) Proc Natl Acad Sci USA 107(38):16477-16482] reports that a reexamination of the evidence overturns Burke et al.'s findings when alternative statistical models and alternative measures of conflict are used. We show that the conclusion by Buhaug is based on absent or incorrect statistical tests, both in model selection and in the comparison of results with Burke et al. When we implement the correct tests, we find there is no evidence presented in Buhaug that rejects the original results of Burke et al.

  1. Reexamination of magnetic isotope and field effects on adenosine triphosphate production by creatine kinase.

    PubMed

    Crotty, Darragh; Silkstone, Gary; Poddar, Soumya; Ranson, Richard; Prina-Mello, Adriele; Wilson, Michael T; Coey, J M D

    2012-01-31

    The influence of isotopically enriched magnesium on the creatine kinase catalyzed phosphorylation of adenosine diphosphate is examined in two independent series of experiments where adenosine triphosphate (ATP) concentrations were determined by a luciferase-linked luminescence end-point assay or a real-time spectrophotometric assay. No increase was observed between the rates of ATP production with natural Mg, (24)Mg, and (25)Mg, nor was any significant magnetic field effect observed in magnetic fields from 3 to 1,000 mT. Our results are in conflict with those reported by Buchachenko et al. [J Am Chem Soc 130:12868-12869 (2008)], and they challenge these authors' general claims that a large (two- to threefold) magnetic isotope effect is "universally observable" for ATP-producing enzymes [Her Russ Acad Sci 80:22-28 (2010)] and that "enzymatic phosphorylation is an ion-radical, electron-spin-selective process" [Proc Natl Acad Sci USA 101:10793-10796 (2005)].

  2. Embryonal cell surface recognition. Extraction of an active plasma membrane component.

    PubMed

    Merrell, R; Gottlieb, D I; Glaser, L

    1975-07-25

    Plasma membranes obtained from different neural regions of the chicken embryo have previously been shown to specifically bind to homotypic cells and prevent cell aggregation (Merrell, R., and Glaser, L. (1973) Proc. Natl. Acad. Sci. U. S. A. 70, 2794-2798). Proteins responsible for the specific inhibition of cell aggregation have been solubilized from the plasma membrane of neural retina and optic tectum by delipidation with acetone followed by extraction with lithium diiodosalicylate. The extracts show the same regional and temporal specificity as previously shown for plasma membrane recognition by the same cells (Gottlieb, D. I., Merrell, R., and Glaser, L. (1974) Proc. Natl. Acad. Sci. U. S. A. 71, 1800-1802). Two micrograms of the most purified protein fraction inhibits the aggregation of 2.5 times 10(-4) cells under standard assay conditions. This represents a 20-fold increase in specific activity compared to whole membranes.

  3. Significance of endangered and threatened plant natural products in the control of human disease.

    PubMed

    Ibrahim, Mohamed Ali; Na, MinKyun; Oh, Joonseok; Schinazi, Raymond F; McBrayer, Tami R; Whitaker, Tony; Doerksen, Robert J; Newman, David J; Zachos, Louis G; Hamann, Mark T

    2013-10-15

    One in five of the world's plant species is threatened with extinction according to the 2010 first global analysis of extinction risk. Tilman et al. predicted a massive ecological change to terrestrial plants within the next 50-100 y, accompanied by an increase in the number of global plant species facing extinction [Tilman D, et al. (2001) Proc Natl Acad Sci USA 98(10):5433-5440]. Most of the drug-producing plant families contain endangered species never previously studied for their utility to human health, which strongly validates the need to prioritize protection and assessment of these fragile and endangered groups [Zhu F, et al. (2011) Proc Natl Acad Sci USA 108(31):12943-12948]. With little prior attention given to endangered and rare plant species, this report provides strong justification for conservation of the rare plant Diplostephium rhododendroides Hieron., as well as other potential drug-producing endangered species in this and other groups.

  4. Discovery of Potent Inhibitors for Breast Cancer Multidrug Resistance

    DTIC Science & Technology

    2006-03-01

    al., 1998; Ogino et al., 1996; Williams and Jacobs, 1993). These molecules typically have a smaller ring size than cycloporin A derivatives (hexa- or...1984). J. Ogino , R. E. Moore, G. M. L. Patterson, C. D. Smith, Journal of Natural Products 59, 581 (Jun, 1996). Klopman, L. M. Shi, A. Ramu...Acad. Sci. U. S. A. 87, 7225-7229 (1990). 26. Ogino , J., Moore, R.E., Patterson, G.M., Smith, C.D. Dendroamides, new cyclic hexapeptides from a

  5. Prevention of Human Mammary Carcinogenesis.

    DTIC Science & Technology

    1996-07-01

    of HER-2/neu oncogene-transformed human mammary epithelial cells by a green tea polyphenol. Breast Cancer Res Treat 38:100; 1996 8. Telang NT, Katdare...apoptosis and anchorage-dependent colony forming efficiency. Appendix Figure 5 (AF-5): Effect of (-) epigallo catechin gallate (EGCG) on 184- B5/HER cells is... tea polyphenol. Ann. NY Acad. Sci. 768: 215- 222, 1995. Appendix Pubilcation 5 (AP-5): Fishman J, Osborne MP, Telang NT. The role of estrogen in

  6. Network analysis of human heartbeat dynamics

    NASA Astrophysics Data System (ADS)

    Shao, Zhi-Gang

    2010-02-01

    We construct the complex networks of human heartbeat dynamics and investigate their statistical properties, using the visibility algorithm proposed by Lacasa and co-workers [Proc. Natl. Acad. Sci. U.S.A. 105, 4972 (2008)]. Our results show that the associated networks for the time series of heartbeat interval are always scale-free, high clustering, hierarchy, and assortative mixing. In particular, the assortative coefficient of associated networks could distinguish between healthy subjects and patients with congestive heart failure.

  7. Gene Therapy of Breast Cancer: Studies of Selective Promoter/Enhancer-Modified Vectors to Deliver Suicide Genes

    DTIC Science & Technology

    1998-09-01

    antigen - expressing tu- 36. Wickham. TJ.. P. Mathias. D.A. Cheresh. and G.R. Nemerow. 1993. In- mor cells in bone marrow aspirates by polymerase chain ...transduction of Escherichia Coi lacZ. Proc." 1992. Detection of tumor cells in bone marrow of patients with primary breast Nail. Acad. Sci. USA. 85:2603-2607...tissue specific /selective promoter or enhancer to direct the expression of a therapeutic gene in the desired target

  8. Molecular Basis of Paralytic Neurotoxin Action on Voltage-Sensitive Sodium Channels

    DTIC Science & Technology

    1988-10-20

    channels in intact membranes (Messner et al, 1986; Tejedor & Catterall, 1988). The a subunits of the sodium channels in these reconstimtpd vesicles...1986; Tejedor & Catterall, 1988). In preliminary experiments, proteases were screened to find experimental conditions under which the a subunit could...1688, Tejctor, FJ. and Catterall, W.A. (1988) Biochemistry, in press, Tejedor , F.J. and Catterall, W.A. (1988) Proc. Nail, Acad. Sci. USA, in press

  9. Large Eddy Simulation ... Where Do We Stand? International Workshop Held in St. Petersburg Beach, Florida on 19-21 December 1990.

    DTIC Science & Technology

    1990-01-01

    Contribution of Two-Point Closure to Large-Eddy Simulation. 3. A. J. Chorin Accesion For Application of Statistical Mechanics to Turbulence Modeling ...and DNS of Reacting Homogeneous Turbulence , 3. C. E. Leith Stochastic Backscatter in a Subgrid-Scale Model : 3D Compressible Flows. 4. G. Erlebacher and... models and non- linear viscosities. REFERENCES Bass, J., 1949: Sur les bases mathdmatiques de la thdorie de la turbulence d’Heisenberg. C. R. Acad. Sci

  10. Development of a Mouse Model for Determination of the Role of the Catechol Metabolites of Estradiol in Mammary Tumorigenesis

    DTIC Science & Technology

    2005-08-01

    renal tumorigenesis in the Syrian hamster model4 and DNA damage in human MCF-7 cells5, suggesting that COMT is highly protective against adverse effects...Wnt (COMTKO/ERKO /Wnt). However, ERKO females and males are infertile and Wnt females cannot nurse their young. Thus, the desired females must be...the initiation of cancer and other diseases by catechol quinones. Ann N Y Acad Sci 2004;1028:247-57. 3. Devanesan P, Santen RJ, Bocchinfuso WP, Korach

  11. Diagnosis and Treatment of Phantom Limb Pain: Mechanisms and Option FLow Sheet.

    DTIC Science & Technology

    1982-08-01

    related to causalgia like burning pain.4 u Beta blockers may be of some use to treat this portion of the problem. A recent report shows success upon...psychological aspects. Annals N.Y. Acad. Sci. 74:14, 1958. 4. Marsland, A., Weeks, J., Atkinson, R., and Leong, M.: Phantom limb pain: A case for beta ... blockers ? Pain 12, 295, 1982. 5. Meizack, R.: Phantom limb pain: Implications for treatment of pathologic pain. Anesthesiology 35(4):409, 񓟓. 6

  12. Algorithms for Automated DNA Assembly

    DTIC Science & Technology

    2010-01-01

    polyketide synthase gene cluster. Proc. Natl Acad. Sci. USA, 101, 15573–15578. 16. Shetty,R.P., Endy,D. and Knight,T.F. Jr (2008) Engineering BioBrick vectors...correct theoretical construction scheme is de- veloped manually, it is likely to be suboptimal by any number of cost metrics. Modular, robust and...to an exhaustive search on a small synthetic dataset and our results show that our algorithms can quickly find an optimal solution. Comparison with

  13. Preclinical Mouse Models of Neurofibromatosis

    DTIC Science & Technology

    2006-10-01

    Patients. Persons with NF1 are predisposed to benign neurofibromas, optic nerve gliomas, and to specific malignant neoplasms . Individuals with NF1...malignant neoplasms seen in NF1 patients include astrocytoma, malignant peripheral nerve sheath tumor (MPNST), pheochromocytoma, and juvenile...Kras in hematopoietic cells initiates a rapidly fatal myeloproliferative disorder. Proc Natl Acad Sci U S A 2004;101(2):597-602. 14. Chan IT, Kutok JL

  14. X-Ray Phase Imaging for Breast Cancer Detection

    DTIC Science & Technology

    2012-09-01

    Fla., 2003). 31. J. H. Hubbell, W. I. Veigele, E. A. Briggs , et al., “Atomic form factors, incohoerent scattering functions, and photon scattering...network,” Proc. Natl. Acad. Sci. 103, 14626–14630 (2006). 15T. Gureyev, D. Paganin, G. Myers , Ya. Nesterets, and S. Wilkins, “Phase- and-amplitude...Wagner, K. Doi, D. Brown, R. Nishikawa and K. Myers , Toward consensus on quantitative assessment of medical imaging systems, Medical Physics 22 (1995

  15. Stimulation of Estrogen Receptor Signaling in Breast Cancer by a Novel Chaperone Synuclein Gamma

    DTIC Science & Technology

    2005-06-01

    Research Institute, Department of Radiation Oncology , Long Island Jewish Medical Center, Albert Einstein College of Medicine, New Hyde Park, New York...Radiation Oncology , Long Island Jewish Medical Center, New Hyde Park, NY 11040. Phone: (718) 470-3086; Fax: (718) 470-9756; E-mail: shi@lij.Edu. 4539...and stimulates A beta aggregation. Proc Natl Acad Sci USA 92:9141–5. 12. Duda JE, Lee VM, Trojanowski JQ. Neuropathology of synuclein aggregates. J

  16. Spontaneous Buckling of Lipid Bilayer and Vesicle Budding Induced by Antimicrobial Peptide Magainin 2: A Coarse-Grained Simulation Study

    DTIC Science & Technology

    2011-05-30

    test of this hypothesis can be achieved by molecular simulation techniques, and here we report a study of magainin 2-induced membrane permeabilization...associated with the surface tension imbalance across the bilayer. The Size of Vesicular Bud Is Independent of System Sizes. In order to test how the...Proc. Natl. Acad. Sci. U.S.A. 2008, 105, 10803. (39) Lindahl, E.; Hess, B.; van der Spoel, D. J. Mol. Model. 2001, 7, 306. (40) Gesell , J.; Zasloff, M

  17. A Nonlinear Transfer Operator Theorem

    NASA Astrophysics Data System (ADS)

    Pollicott, Mark

    2017-02-01

    In recent papers, Kenyon et al. (Ergod Theory Dyn Syst 32:1567-1584 2012), and Fan et al. (C R Math Acad Sci Paris 349:961-964 2011, Adv Math 295:271-333 2016) introduced a form of non-linear thermodynamic formalism based on solutions to a non-linear equation using matrices. In this note we consider the more general setting of Hölder continuous functions.

  18. Memory neuron: synapse microchemistry for the memory component of a neuroconnective brain model.

    PubMed Central

    Wooldridge, D E

    1980-01-01

    This paper examines the synaptic microchemistry required if a memory neuron is to have the operating characteristics previously attributed to it [Wooldridge, D.E. (1980) Proc. Natl. Acad. Sci. USA, 77,2305-2308]. It is concluded that the requirements can be met by a combination of membrane mechanisms not very different from those that are commonly postulated to explain the properties of known types of neurons. PMID:6248883

  19. Unobserved time effects confound the identification of climate change impacts

    PubMed Central

    Auffhammer, Maximilian; Vincent, Jeffrey R.

    2012-01-01

    A recent study by Feng et al. [Feng S, Krueger A, Oppenheimer M (2010) Proc Natl Acad Sci USA 107:14257–14262] in PNAS reported statistical evidence of a weather-driven causal effect of crop yields on human migration from Mexico to the United States. We show that this conclusion is based on a different statistical model than the one stated in the paper. When we correct for this mistake, there is no evidence of a causal link. PMID:22783021

  20. Vaccine-Preventable Adenoviral Respiratory Illness in US Military Recruits, 1999-2004

    DTIC Science & Technology

    2007-08-29

    cell lines permissive to growth of adenovirus, influenza A, influenza B, parainfluenza viruses , enteroviruses, and respiratory syncytial virus ...PubMed: 13376914] 8. Hilleman MR. Epidemiology of adenovirus respiratory infections in military recruit populations. Ann N Y Acad Sci 1957;67(8):262–72...infectious virus dose and protective effect of enteric infection . Am J Epidemiol 1967;86(2):341–9. [PubMed: 4293744] 20. Buescher EL. Respiratory disease

  1. Complex Host Genetics Influence the Microbiome in Inflammatory Bowel Disease

    DTIC Science & Technology

    2016-09-09

    microbial ecology . Proc Natl Acad Sci U S A 2005, 102:11070–11075. 17. Hashimoto T, Perlot T, Rehman A, Trichereau J, Ishiguro H, Paolino M, Sigl V...JM: ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation. Nature 2012, 487:477–481. 18. Cortes A, Brown MA: Promise and...DeSantis TZ, Probst A, Andersen GL, Knight R, Hugenholtz P: An improved Greengenes taxonomy with explicit ranks for ecological and evolutionary analyses of

  2. Annotated Bibliography of Reports: Supplement No. 7, 1 July 1974 - 30 June 1975,

    DTIC Science & Technology

    1975-06-30

    N.A., Lu, S., and Maglin , R., Biochemical and Neuroendocrine Aspects of Exposure to Micro- waves. Proc. N.Y. Acad. Sci. Symp. on the Biological...Lewis, J.A. -19 * Lu, S. -19 Maglin , R. - 19 Marr, M.J. - 18 Maxwell, D.W. - 19 Michaelson, S.M. 1.j9 Miller, E.F. 11 1(1, 18 Moore, H.J. - 2 Moroney, W.F. - 8 Mosko, J.D. -20 21

  3. Protection by Purines in Toxin Models of Parkinson’s Disease

    DTIC Science & Technology

    2015-08-01

    pharmacological effects of inosine at doses that will further elevate urate, as it does in (UOx- deficient ) humans. Cre recombination was induced by routine...Jones P, Bradley A, Caskey CT. (1994) Hyperuricemia and urate nephropathy in urate oxidase- deficient mice. Proc Natl Acad Sci U S A. 91(2):742-6. 11...Dietary folate deficiency and elevated homocysteine levels endanger dopaminergic neurons in models of Parkinson’s disease. J Neurochem. 80, 101-10

  4. Tropomyosin-1, A Putative Tumor-Suppressor and a Biomarker of Human Breast Cancer

    DTIC Science & Technology

    2004-10-01

    in Caenorhabditis elegans show that CeTM inhibits ADF/ 5. Hendricks, M., and Weintraub, H. (1981) Proc. Natl. Acad. Sci. U. S. A. 78, 5633-5637...directed mutagenesis to introduce a silent mutation to create a Hindiii restriction site. This was accomplished by PCR and the resultant variants of...FMR1 gene which is mutated in fragile X isoform that is also found in fibroblasts [7]. In breast syndrome [17,25,26]. Consistent with this notion

  5. Repair Machinery for Radiation-Induced DNA Damage

    DTIC Science & Technology

    2002-07-01

    Chinese hamster CHO cell line as the system for producing knockout mutations, since they present the many advantages described in the original...Rainbow, and R. S. Nairn. 1997. Survival, mutagenesis, and host cell reactivation in a Chinese hamster ovary cell ERCC1 knock-out mutant. Mutagenesis...recombination at the endogenous adenine phosphoribosyltransferase locus in Chinese hamster cells . Proc. Natl. Acad. Sci. U.S.A. 86:4574-4578. 8

  6. Design and Synthesis of Substituted Cyclopropanes as Conformationally Restrained Dipeptide Mimics.

    DTIC Science & Technology

    1992-05-01

    M .; Cramer, R . D .; Opdenbosch, N. V. J . Comp. Chem. 1989, 8, 982. (b) Weiner, S . J .; Kollman, P. A.; Case, D . A.; Singh, U . C .; Ghio, C .; Alagona...Darke, P. L.; Diccarone, T. M .; Colton, C . D .; Rodkey, J . A.; Bennet, C . D .; Waxman, L. N.; Sigal, 1. S . Proc. Nati. Acad. Sci. U . S . A. 1988, 8S, 7129...Heinrikson, R . L.; Tomick, C . C . Biochemistry

  7. Wavelength Independent Optical Lithography.

    DTIC Science & Technology

    1986-06-06

    lamp because it has a smooth, broadband output in the visible and near UV. High Density Optical Intormation Storage The NSOM concept can be combined...stringent control can be maintained over the temperature of the entire apparatus. Ideally, both of these methods should be used. - . * S P. .~ V: -:V- TwT ...DNA helixes : enantiomers of tris(4, 7-diphenylpheanthroline)ruthenium (II). Proc. Natl. Acad. Sci. U.S.A. 81, 7 (1984). 27. J.M. Fernandez, E. Neher

  8. Two-Photon Porphyrin Core Dendrimers for Optical Power Limiting

    DTIC Science & Technology

    2006-09-30

    Gryko (Polish Acad. Sci,), we studied 2PA of novel corroles [9]. 7. We studied the requirements imposed on organic photochromes for 2PA terabyte...imposed on organic photochromes for two-photon absorption (2PA) terabyte volumetric optical storage. We present a quantitative model of signal-to...noise ratio (SNR) and signal-to-background ratio (SBR) when 2PA-induced photochromic switching is used for writing, and 2PA-induced fluorescence is

  9. Mechanisms and Chemoprevention of Ovarian Carcinogenesis

    DTIC Science & Technology

    2009-02-01

    Beauchamp R, et al. p53 gene mutations and protein accumulation in human ovarian cancer. Proc Natl Acad Sci USA 1993;90:4961–5. 34. Wang Y, Helland A, Holm R...39, 1339–1346. Nielsen,T.O., West,R.B., Linn,S.C., Alter,O., Knowling,M.A., O’Connell,J.X., Zhu,S., Fero,M., Sherlock ,G., Pollack,J.R. et al. (2002

  10. Glutamate Receptor Aptamers and ALS

    DTIC Science & Technology

    2008-01-01

    that the evolutionary conversion of a ribozyme (RNA) to a deoxribozyme (DNA) of the same function can be accomplished but only with some critical...the role of neutrality in adaptation. Proc Natl Acad Sci U S A 93, 397-401. 40. Schultes, E. A., and Bartel, D. P. (2000) One sequence, two ribozymes ...implications for the emergence of new ribozyme folds. Science 289, 448-452. 41. Mandal, M., and Breaker, R. R. (2004) Gene regulation by

  11. Chemical Communications

    DTIC Science & Technology

    2012-04-27

    characters; bubble shutter; infofuse; IR detection; IR emission; optical transmission; atomic emission beacon; info biology L. Mahadevan, David Walt, George...Faculty Supported National Academy MemberPERCENT_SUPPORTEDNAME George M. Whitesides 0.10 Yes L. Mahadevan 0.08 David Walt 0.10 0.28FTE Equivalent...biofilm consortium. Proc Natl Acad Sci USA 104(44):17300-17304. 18. Tamsir A, Tabor JJ, & Voigt CA (2011) Robust multicellular computing using

  12. BioCores: identification of a drug/natural product-based privileged structural motif for small-molecule lead discovery.

    PubMed

    Kombarov, Roman; Altieri, Andrea; Genis, Dmitry; Kirpichenok, Mikhail; Kochubey, Valeriy; Rakitina, Natalia; Titarenko, Zoya

    2010-02-01

    The analysis of known drugs (Comprehensive Medicinal Chemistry database (2008 version): http://www.mdl.com/products/knowledge/medicinal_chem/index.jsp ) and natural products (Koch et al., Proc Natl Acad Sci USA 102:17272-17277, 2008) has led to the identification of privileged saturated and aromatic heterocyclic ring pairs that we have termed as "BioCores." This article explains how the BioCores can be used for the design of novel lead-like scaffolds.

  13. Proceedings of the 2nd Annual Conference on Atmospheric Contamination in Confined Spaces, 4 and 5 May 1966

    DTIC Science & Technology

    1966-12-01

    With respect to the ultrastructure of the damages, our findings differ in some points from those of Cedergren et al (ref 14). We could not find any...as compared to the earlier work of Cedergren et al. In the other points our observations agree, particularly with respect to the occurrence of...N. Y. Acad. Sci., Vol 121, p 823, 1965. 145 REFERENCES (CONT’D) 14. Cedergren , B., L. Gyllensten, and J. Wersall, Acta Pediat., Vol 48, p 477, 1959

  14. Biomarker Discovery and Mechanistic Studies of Prostate Cancer using Targeted Proteomic Approaches

    DTIC Science & Technology

    2012-07-01

    from OligoEngine according to the manufac- turer’s instruction. Plasmids were amplified in DH5a cell and confirmed by sequencing . Subconfluent cell...non-coding, double stranded RNA molecules that can induce gene transcription by targeting promoter regions specific to the gene of interest... sequences of human and rat androgen receptors. Proc Natl Acad Sci USA 85: 7211-7215, 1988. 19. hsing AW, Chokkalingam AP, Gao YT, et al: Polymorphic CAG

  15. Impact of Erb-B Signaling on Myelin Repair in the CNS Following Virus-Induced Damage

    DTIC Science & Technology

    2012-03-01

    of single - stranded RNA viruses by Toll-like receptor 7. Proc Nat Acad Sci USA 101, 5598-5603 (2004) 73. Brian G. Weinshenker, David Hebrink...gene compared to healthy controls 127. 156  No differences in frequency were observed. A different study examined single nucleotide 157  polymorphisms ...a single LNS domain functions as an independently folding ligand-binding unit. J Biol Chem 273: 34716-34723. 3. Missler, M. and T. C. Südhof

  16. Thermodynamic Functions of Fluorine and Some of its Compounds

    DTIC Science & Technology

    1950-07-01

    whereas a Gerhard & Dcnnison extrapolation of measurements on the Q, P and R branches give I. = 98, I-g = I_ = 401 which arc obviously too low. The...1948) 398. 14. Venkateswarlu. Proc. Ind. Acad. Sci. 24*i (1946) 473, 480; 25A (1947) 119, 133, 151. 15. G. Herzberg . ’Molecular Spectra...1949) 501. 22. G. Herzberg . ’Molecular Spectra & Molecular Structure*, II. New York 1947. /23. -15 - RESTRICTED RESTRICTED 23. Ta-You-Wu

  17. Maintenance of Glucose Homeostasis through Acetylation of the Metabolic Transcriptional Coactivator PGC-1alpha

    DTIC Science & Technology

    2008-02-01

    GCN5 in cells using adenoviruses that encode both proteins. 12 hours before harvesting, cells were treated with nicotinamide (a SIRT1 deacetylase...Hepatic SIRT1 . Proc. Natl. Acad. Sci. USA. 2007 104(31) 12861-12866. C. Lerin, T.J. Kelly, W. Haas, S.P. Gygi, and P. Puigserver. GCN5-Mediated...Puigserver. Metabolic Adaptations Through PGC-1α and SIRT1 Pathways. FEBS Letters. 582: 46-53. 2008 - University of Utah. Department of

  18. DNA Damage in Embryonic Stem Cells Caused by Nanodiamonds

    DTIC Science & Technology

    2011-03-03

    have important implications for future applications of NDs in biological applications . KEYWORDS: nanodiamond . DNA damage . embryonic stem cells... Application of Single Fluorescent Nanodiamonds as Cellular Biomarkers. Proc. Natl. Acad. Sci. U.S.A. 2007, 104, 727–732. 7. Vial, S.; Mansuy, C.; Sagan...S.; Pozdnyakova, I. O.; Puzyr, A. P. Applications of Nanodiamonds for Separation and Purification of Proteins. Phys. Solid State 2004, 46, 758–760

  19. ERG Expression Levels in Prostate Tumors Reflect Functional Status of the Androgen Receptor (AR) as a Consequence of Fusion of ERG with AR Regulated Gene Promoters

    DTIC Science & Technology

    2010-01-01

    literature review. Asian J Androl 2008; 10: 855-63. [30] Donovan MJ , Osman I, Khan FM, et al. Androgen receptor expression is associated with...Nat Rev Urol 2009; 6: 429-39. [8] Heinlein CA, Chang C. Androgen receptor in prostate cancer. Endocr Rev 2004; 25: 276-308. [9] Linja MJ , Visakorpi...Klezovitch O , Risk M, Coleman I, et al. A causal role for ERG in neoplastic transformation of prostate epithelium. Proc Natl Acad Sci USA 2008; 105: 2105

  20. Normal Coagulation

    DTIC Science & Technology

    2014-09-04

    protein E deficiency exhibit an increased atherosclerotic burden.112 These observations suggest a role for TFPI in pro- tection from atherosclerosis and...Clin Invest 103:475–482, 1999. 112. Westrick RJ, et al: Deficiency of tissue factor pathway inhibitor pro- motes atherosclerosis and thrombosis in...system. Ann N Y Acad Sci 936:226–236, 2001. 223. Hansson GK: Inflammation, atherosclerosis , and coronary artery disease. N Engl J Med 352:1685–1695

  1. Pathophysiology of Post Amputation Pain

    DTIC Science & Technology

    2014-12-01

    nociception and pain : analysis through imaging. Proc Natl Acad Sci U S A 1999;96:7668-74. 44. Casey KL, Minoshima S, Morrow TJ, Koeppe RA. Comparison of...trials. Eur J Pain 2006;10:77-88. 95. Dotson RM. Clinical neurophysiology laboratory tests to assess the nociceptive system in humans. J Clin...Award Number: W81XWH-11-1-0815 TITLE: Pathophysiology of Post Amputation Pain PRINCIPAL INVESTIGATOR: Dr. R. Norman Harden CONTRACTING

  2. Radiometric Methods for Rapid Diagnosis of Viral Infection.

    DTIC Science & Technology

    2014-09-26

    Miller G: Assay for Epstein - Barr virus based on stimulation of DNA synthesis in mixed leukocytes from human umbilical cord blood. J Virol 15: 1065...Activation of Epstein - Barr virus by 5-bromodeoxyuridine in " virus -free" human cells. Proc Natl Acad Sci USA 69: 83-85, 1972. 24. LeMevel BP, Wells SA...Thus, there are viruses , such as West Nile virus , which multiply in the cell culture, but do not produce any cytopathic effect. Our radlometric technique

  3. Newton’s Rotating Water Bucket: A Simple Model

    DTIC Science & Technology

    2013-01-01

    University of America Press, Washington, DC Abstract Isaac Newton proposed hanging a bucket of water by a cord in the Principia. If the cord is...Acad. Sci. 99, 15 (Summer 2013) 14. ABSTRACT Isaac Newton proposed hanging a bucket of water by a cord in the Principia. If the cord is twisted and...As the bucket spins faster, the water level drops in the center and rises up near the walls, as Newton noted. 18 Washington Academy of Sciences

  4. Overexpression of Human Senescence Marker Protein 30 in Mice Fails to Offer Protection Against Challenge with Organophosphorus Compounds

    DTIC Science & Technology

    2011-09-01

    organophosphate poisoning . Proc Natl Acad Sci U S A 104: 13603-13608. 8. Ashani Y, Pistinner S (2004) Estimation of the upper limit of human...life-threatening risk to both soldiers and civilians [1]. Current antidotal regimen for OP poisoning includes anticholinergic drugs to counteract the...Eyer P, Felgenhauer N, Zilker T, Worek F. (2007) Lessons to be learnt from organophosphorus pesticide poisoning for the treatment of nerve agent

  5. Environmental Genome Analysis: Polymerase Chain Reaction Fingerprinting on In Situ Extracted Bacterial mRNA from Contaminated Soils.

    DTIC Science & Technology

    1998-03-31

    PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) 8. PERFORMING ORGANIZATION REPORT NUMBER University of Tennessee 404 Andy Holt Tower Knoxville, TN 37996-0140... Tennessee Knoxville, TN 37932 (423) 974-8080 Table of contents Abstract ......................... ............................... 1 Introduction...and M. McClelland. 1994. Stress-inducible gene of Salmonella typhimurium identified by arbitrarily primed PCR of RNA. Proc. Natl. Acad. Sci. 91:639

  6. Helicity-Selective Phase-Matching and Quasi-Phase matching of Circularly Polarized High-Order Harmonics: Towards Chiral Attosecond Pulses

    DTIC Science & Technology

    2016-05-23

    efficiency Proc. Natl Acad. Sci. USA 112 4846–51 [13] Miao J, Ishikawa T, Robinson I K and Murnane M M 2015 Beyond crystallography: diffractive imaging using...Kosuge A, Hayashi T, Kanai T, Itatani J, Adachi S and Watanabe S 2008 Quantum path selection in high-harmonic generation by a phase-locked two- color ...resolution imaging of atoms, molecules, condensed matter and nano-structures [1–14]. While many schemes were Journal of Physics B: Atomic, Molecular

  7. Field Survey of Heavy Metal Uptake by Naturally Occurring Saltwater and Freshwater Marsh Plants.

    DTIC Science & Technology

    1981-06-01

    Marcks, B. G. 1974. Preliminary reports on the flora of Wisconsin. No. 66. Cyperaceae II - Sedge family I. The genus Ojperus - the umbrella sedges ...field were collected from areas that flooded during rains and subsequently dried out. Additionally, the Cyperaceae are among the first species present in...Trans. Wis. Acad. Sci. Arts Lett. 62:261-284. Mohlenbrock, R. H. 1960. The Cyperaceae of Illinois. I. Cyperus. Am. Mid. Nat. 63:270-306. Reddy, C. N

  8. Temporal Progression of Pneumonic Plague in Blood of Nonhuman Primate: A Transcriptomic Analysis

    DTIC Science & Technology

    2016-03-22

    Johnston SA (2004) The temporal expression profile of Mycobacte- rium tuberculosis infection in mice. Proc Natl Acad Sci U S A 101: 4602–4607. PMID...omics approach with comprehensive evaluation of the organs, such as lungs which showed early bacterial infection , is essential. PLOS ONE | DOI:10.1371...pestis (Y. pestis) to rapidly multiply, coupled with its atypical symptoms at the initial stage of infection , presents daunting challenges for

  9. Quantifying Hurricane Wind Speed with Undersea Sound

    DTIC Science & Technology

    2006-06-01

    138]. These second order non-linear or perturbation-based theories should not be con- fused with the linear theories proposed by Banerji [5] and Bowen...October 2001. Technical report, National Hurricane Center, 2001. [5] S. K. Banerji . Microseisms associated with disturbed weather in the indian seas...Phil. Trans. Roy. Soc. Lon. Ser. A., 229:287-328, 1930. [6] S. K. Banerji . Theory of microseisms. Proc. Indian Acad. Sci., 1:727-753, 1935. [7] R. L

  10. A Molecular Epidemiologic Case-Case Study of Prostate Cancer Susceptibility.

    DTIC Science & Technology

    1999-09-01

    and Krolick., K. A. Acetylcholine receptor-reactive antibodies in experimental Autoimmune myasthenia gravis differing in disease-causing potential...and Krolick, K. A. Preferential use of a T cell receptor VB gene by acetylcholine receptor-reactive T cells from myasthenia gravis susceptible mice. J...on the induction of experimental myasthenia gravis . Ann. New York Acad. Sci. 681:179-197, 1993. Thompson, P. A., McAtee, R., Infante, A. J., Currier

  11. Isolation and Growth of Prostate Stem Cells and Establishing Cancer Cell Lines from Human Prostate Tumors

    DTIC Science & Technology

    2009-05-01

    RU, Cheng D, and Witte ON. Isolation and functional characterization of murine prostate stem cells. Proc Natl Acad Sci U S A 2006; 29. Cunha GR...Hopkins School of Medicine Flow Sorting Facility) for their expert assistance and Jessica Hicks and Yuko Konishi (Johns Hopkins Department of...P. Mouse urogenital development: a practical approach. Differentiation 2003;71:402–13. 29. Xin L, Ide H, Kim Y, Dubey P, Witte ON. In vivo

  12. Isolation and Growth of Prostate Stem Cells and Establishing Cancer Cell Lines from Human Prostate Tumors

    DTIC Science & Technology

    2008-05-01

    Kim, Y., Dubey, P., and Witte , O. N. In vivo regeneration of murine prostate from dissociated cell populations of postnatal epithelia and urogenital...R. U., Cheng, D., and Witte , O. N. Isolation and functional characterization of murine prostate stem cells. Proc Natl Acad Sci U S A, 2006. 34...of Medicine Flow Sorting Facility) for their expert assistance and Jessica Hicks and Yuko Konishi (Johns Hopkins Department of Pathology) for the

  13. Growth Suppression and Therapy Sensitization of Breast Cancer

    DTIC Science & Technology

    2000-07-01

    Laboratories Inc.), which incorporates an internal ribosome binding site (IRES) and generates a bicistronic message in which the subcloned gene of interest...suppression and apoptosis." Presented at the AACR Special Conference on DNA repair Defects, San Diego CA, January 14- 18, 2000. 12 PROPRIETARY...alter p53 in breast cancer: mutation and nuclear exclusion. Proc. Natl. Acad. Sci., USA 89:7262-7266. 5. Hendersin, I.C., Harris, J.R., Kinne, D.W

  14. Novel Therapeutic and Prophylactic Modalities to Protect U.S. Armed Forces Against Major Biological Threat Agents

    DTIC Science & Technology

    2004-10-01

    gelatinolytic activities of anthrax proteases. The proteins secreted by three Bacillus species (B. anthracis, B. cereus and B. subtilis) into culture...of 1979. Proc Natl Acad Sci U S A. 90(6):2291-4. Akesson A., Hedstrom SA, and Ripa T (1991). Bacillus cereus : a significant pathogen in postoperative...and Bacillus cereus culture filtrates. 1963. Am J Pathol;43:201-11. Brown SB, Savill J (1999) Phagocytosis triggers macrophage release of Fas ligand and

  15. First International Conference on Numerical Ship Hydrodynamics Held in Gaithersburg, Maryland on 20-22 October 1975.

    DTIC Science & Technology

    1975-01-01

    innovative mathematician and philosopher with a wide range of interests. His impact upon the development of theoretical and numerical hydrodynamics is...Springer-Verlag, Berlin. Gilbarg, D. 1949 Proc. Nat. Acad. Sci. U.S.A., 35, 609-612. Helrnholtz, H. 1868 Uber diskontinuierliche Flits sigkeitsbewegungen...The force of impact on a cone striking a water surface. Comm. Pure Appl. Math. 4, 379-417. Southwell, R. V. and Vaisey, G 1946 Fluid motions

  16. Rickettsia Felis in Xenopsylla Cheopis, Java, Indonesia

    DTIC Science & Technology

    2006-08-01

    Gonzalez JP, et al. Identification of Rickettsia spp. and Bartonella spp. in fleas from the Thai-Myanmar border. Ann N Y Acad Sci. 2003;990:173–81. 6...Oriental rat fleas (Xenopsylla cheopis) collect- ed from rodents and shrews in Java, Indonesia. We describe the first evidence of R. felis in...Indonesia and nat- urally occurring R. felis in Oriental rat fleas . Murine typhus (endemic typhus, fleaborne typhus),caused by Rickettsia typhi, is

  17. Comments on the Special Issue of Communications in Statistics (Volume A8, Number 10) Concerned with Weather Modification Experiments.

    DTIC Science & Technology

    1979-11-01

    Appl. Meteor., 18, 1233-1237. 18 Lovasich, J.L. , Neyman, J ., Scott , E.L. and Wells, M.A. (1971). Further studies of the Whitetop cloud seeding...experiments. Proc. Nat’l Acad. Sci., 68, 649-652. Neyman, J ., Scott , E.L., and Wells, M.A. (1969). Statistics in meteor- ology. Rev. Int’l Stat. Inst., 37

  18. Biologically Plausible Neural Model for the Recognition of Biological Motion and Actions

    DTIC Science & Technology

    2002-08-01

    Natl. Acad. Sci USA, 98, 11656 (2001). 18. A. Puce et al., J. Neurosc. 18, 2188 (1998); J.V. Haxby, E.A. Hoffman, M. I Gobbini, TICS 4, 223 (2000); T...Allison, A. Puce , G. McCarthy, TICS 4, 267 (2000). 19. S.T.Grafton et al., Exp. Brain Res. 112, 103 (1996); G. Rizzolatti et al., Exp. Brain Res

  19. Development of Novel Technetium-99m-Labeled Steroids as Estrogen-Responsive Breast Cancer Imaging Agents

    DTIC Science & Technology

    2007-06-01

    2001, 60, 123-147. 9. Macgregor, J. I.; Jordan, V. C. Basic guide to the mechanisms of antiestrogen action. Pharmacol Rev 1998 , 50, 151-196. 10...recognition and the antagonism of this interaction by tamoxifen. Cell 1998 , 95, 927-937. 14. Tanenbaum, D. M.; Wang, Y.; Williams, S. P.; Sigler, P. B...Crystallographic comparison of the estrogen and progesterone receptor’s ligand binding domains. Proc. Natl. Acad. Sci. U.S.A. 1998 , 95, 5998-6003

  20. Identification of Novel Genes and Candidate Targets in CML Stem Cells

    DTIC Science & Technology

    2008-07-01

    defined developing C57BL/6J mouse tissue and cells. Proc Natl Acad Sci USA 102:18485-18490, 2005. 11. Hirst M, Delaney A, Rogers SA, Schnerch A...than 104 cells. Because of the very low frequency of normal or malignant stem cells in many primary tissues , this limitation still hampers the use of...consent were provided by the Northwest Tissue Center (Seattle). After thawing, human cells expressing lineage (lin) markers of mature blood cells (CD2, CD3