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Sample records for academy press nap

  1. Naps (For Parents)

    MedlinePlus

    ... KidsHealth in the Classroom What Other Parents Are Reading Upsetting News Reports? What to Say Vaccines: Which Ones ... Text Size What's in this article? The Importance of Naps Sleep Needs by Age Signs of ...

  2. NAPS-MS

    PubMed Central

    Gudesblatt, Mark; Kresa-Reahl, Kiren; Brandes, David W.; Sater, Pamela

    2016-01-01

    Background: Patients with multiple sclerosis (MS) have higher rates of fatigue, mood disturbance, and cognitive impairments than healthy populations. Disease-modifying agents may affect sleep. Although patients taking natalizumab often show improvement in fatigue during the first year of therapy, the mechanism behind this effect is unknown. The aim of the NAPS-MS study was to investigate whether natalizumab affected objective measures of sleep as determined by polysomnography (PSG) and multiple sleep latency testing (MSLT) in patients with MS with fatigue or sleepiness initiating therapy. Additional goals were to evaluate changes in measures of fatigue, mood, and cognition and to correlate these measures with objective sleep measures. Methods: Patients underwent PSG and MSLT before their first natalizumab infusion and after their seventh. Patients completed the Modified Fatigue Impact Scale, Fatigue Severity Scale (FSS), Epworth Sleepiness Scale (ESS), and visual analogue scale for fatigue (VAS-F) at their first, fourth, and seventh natalizumab infusions. NeuroTrax cognitive tests and the Hospital Anxiety and Depression Scale (HADS) were performed at the first and seventh natalizumab infusions. Results: Changes in sleep efficiency, wakefulness after sleep onset, and multiple sleep latency from baseline to 6 months of therapy did not reach significance. The FSS, VAS-F, ESS, and HADS scores were significantly improved after 6 months of therapy; cognitive scores were not significantly improved. Conclusions: Although treatment with natalizumab was associated with improvements in fatigue, sleepiness, and mood, changes in objective measures of sleep were not significant. PMID:27551242

  3. The effects of napping on cognitive functioning.

    PubMed

    Lovato, Nicole; Lack, Leon

    2010-01-01

    Naps (brief sleeps) are a global and highly prevalent phenomenon, thus warranting consideration for their effects on cognitive functioning. Naps can reduce sleepiness and improve cognitive performance. The benefits of brief (5-15 min) naps are almost immediate after the nap and last a limited period (1-3h). Longer naps (> 30 min) can produce impairment from sleep inertia for a short period after waking but then produce improved cognitive performance for a longer period (up to many hours). Other factors that affect the benefits from the nap are the circadian timing of the nap with early afternoon being the most favourable time. Longer periods of prior wakefulness favour longer naps over brief naps. Those who regularly nap seem to show greater benefits than those who rarely nap. These conclusions, however, need to be accepted cautiously until more comprehensive research programmes are conducted in which all these parameters are varied. Research is also needed to test the benefits of brief naps taken more naturalistically at the time when sleepiness becomes intrusive. The significant benefits of a brief nap, containing virtually no slow wave EEG activity, are not predicted by the present theory of homeostatic sleep drive (Process S). A new biological process (Process O) suggests that sleep onset followed by only 7-10 min of sleep can result in a substantial increase of alertness because it allows the rapid dissipation of inhibition in the 'wake-active' cells associated with the 'sleep-switch' mechanism rather than the dissipation of Process S.

  4. Alertness management in flight operations - Strategic napping

    NASA Technical Reports Server (NTRS)

    Rosekind, Mark R.; Gander, Philippa H.; Dinges, David F.

    1991-01-01

    Strategic napping in two different flight operation environments is considered to illustrate its application as a fatigue countermeasure. Data obtained from commercial short-haul and long-haul operations demonstrated the utility and current practices of strategic napping. A preplanned cockpit nap acted as an acute 'safety valve' for the sleep loss, circadian disruption, and fatigue that occurs in long-haul flying.

  5. The effects of napping on cognitive functioning.

    PubMed

    Lovato, Nicole; Lack, Leon

    2010-01-01

    Naps (brief sleeps) are a global and highly prevalent phenomenon, thus warranting consideration for their effects on cognitive functioning. Naps can reduce sleepiness and improve cognitive performance. The benefits of brief (5-15 min) naps are almost immediate after the nap and last a limited period (1-3h). Longer naps (> 30 min) can produce impairment from sleep inertia for a short period after waking but then produce improved cognitive performance for a longer period (up to many hours). Other factors that affect the benefits from the nap are the circadian timing of the nap with early afternoon being the most favourable time. Longer periods of prior wakefulness favour longer naps over brief naps. Those who regularly nap seem to show greater benefits than those who rarely nap. These conclusions, however, need to be accepted cautiously until more comprehensive research programmes are conducted in which all these parameters are varied. Research is also needed to test the benefits of brief naps taken more naturalistically at the time when sleepiness becomes intrusive. The significant benefits of a brief nap, containing virtually no slow wave EEG activity, are not predicted by the present theory of homeostatic sleep drive (Process S). A new biological process (Process O) suggests that sleep onset followed by only 7-10 min of sleep can result in a substantial increase of alertness because it allows the rapid dissipation of inhibition in the 'wake-active' cells associated with the 'sleep-switch' mechanism rather than the dissipation of Process S. PMID:21075238

  6. Daytime nap controls toddlers’ nighttime sleep

    PubMed Central

    Nakagawa, Machiko; Ohta, Hidenobu; Nagaoki, Yuko; Shimabukuro, Rinshu; Asaka, Yoko; Takahashi, Noriko; Nakazawa, Takayo; Kaneshi, Yousuke; Morioka, Keita; Oishi, Yoshihisa; Azami, Yuriko; Ikeuchi, Mari; Takahashi, Mari; Hirata, Michio; Ozawa, Miwa; Cho, Kazutoshi; Kusakawa, Isao; Yoda, Hitoshi

    2016-01-01

    Previous studies have demonstrated that afternoon naps can have a negative effect on subsequent nighttime sleep in children. These studies have mainly been based on sleep questionnaires completed by parents. To investigate the effect of napping on such aspects of sleep quality, we performed a study in which child activity and sleep levels were recorded using actigraphy. The parents were asked to attach actigraphy units to their child’s waist by an adjustable elastic belt and complete a sleep diary for 7 consecutive days. 50 healthy young toddlers of approximately 1.5 years of age were recruited. There was a significant negative correlation between nap duration and both nighttime sleep duration and sleep onset time, suggesting that long nap sleep induces short nighttime sleep duration and late sleep onset time. We also found a significant negative correlation between nap timing and nighttime sleep duration and also a significant positive correlation between nap timing and sleep onset time, suggesting that naps in the late afternoon also lead to short nighttime sleep duration and late sleep onset. Our findings suggest that duration-controlled naps starting early in the afternoon can induce a longer nighttime sleep in full-term infants of approximately 1.5 years of age. PMID:27277329

  7. Academy Rewards.

    ERIC Educational Resources Information Center

    Schnitzer, Denise K.

    2003-01-01

    Granby High School in Norfolk, Virginia, is a large comprehensive high school restructured into four smaller academies that allow students a more personal learning environment. Positive growth is shown in test scores, dropout rates, and the narrowing achievement gap between minority and majority students. (MLF)

  8. Daydreams and nap dreams: Content comparisons.

    PubMed

    Carr, Michelle; Nielsen, Tore

    2015-11-01

    Differences between nighttime REM and NREM dreams are well-established but only rarely are daytime REM and NREM nap dreams compared with each other or with daydreams. Fifty-one participants took daytime naps (with REM or NREM awakenings) and provided both waking daydream and nap dream reports. They also provided ratings of their bizarreness, sensory experience, and emotion intensity. Recall rates for REM (96%) and NREM (89%) naps were elevated compared to typical recall rates for nighttime dreams (80% and 43% respectively), suggesting an enhanced circadian influence. All attribute ratings were higher for REM than for NREM dreams, replicating findings for nighttime dreams. Compared with daydreams, NREM dreams had lower ratings for emotional intensity and sensory experience while REM dreams had higher ratings for bizarreness and sensory experience. Results support using daytime naps in dream research and suggest that there occurs selective enhancement and inhibition of specific dream attributes by REM, NREM and waking state mechanisms. PMID:26164253

  9. Daydreams and nap dreams: Content comparisons.

    PubMed

    Carr, Michelle; Nielsen, Tore

    2015-11-01

    Differences between nighttime REM and NREM dreams are well-established but only rarely are daytime REM and NREM nap dreams compared with each other or with daydreams. Fifty-one participants took daytime naps (with REM or NREM awakenings) and provided both waking daydream and nap dream reports. They also provided ratings of their bizarreness, sensory experience, and emotion intensity. Recall rates for REM (96%) and NREM (89%) naps were elevated compared to typical recall rates for nighttime dreams (80% and 43% respectively), suggesting an enhanced circadian influence. All attribute ratings were higher for REM than for NREM dreams, replicating findings for nighttime dreams. Compared with daydreams, NREM dreams had lower ratings for emotional intensity and sensory experience while REM dreams had higher ratings for bizarreness and sensory experience. Results support using daytime naps in dream research and suggest that there occurs selective enhancement and inhibition of specific dream attributes by REM, NREM and waking state mechanisms.

  10. A novel NAP member GhNAP is involved in leaf senescence in Gossypium hirsutum

    PubMed Central

    Fan, Kai; Bibi, Noreen; Gan, Susheng; Li, Feng; Yuan, Shuna; Ni, Mi; Wang, Ming; Shen, Hao; Wang, Xuede

    2015-01-01

    Premature leaf senescence has a negative influence on the yield and quality of cotton, and several genes have been found to regulate leaf senescence. Howeer, many underlying transcription factors are yet to be identified. In this study, a NAP-like transcription factor (GhNAP) was isolated from Gossypium hirsutum. GhNAP has the typical NAC structure and a conserved novel subdomain in its divergent transcription activation region (TAR). GhNAP was demonstrated to be a nuclear protein, and it showed transcriptional activation activity in yeast. Furthermore, the expression of GhNAP was closely associated with leaf senescence. GhNAP could rescue the delayed-senescence phenotype of the atnap null mutant. Overexpression of GhNAP could cause precocious senescence in Arabidopsis. However, down-regulation of GhNAP delayed leaf senescence in cotton, and affected cotton yield and its fibre quality. Moreover, the expression of GhNAP can be induced by abscisic acid (ABA), and the delayed leaf senescence phenotype in GhNAPi plants might be caused by the decreased ABA level and reduced expression level of ABA-responsive genes. All of the results suggested that GhNAP could regulate the leaf senescence via the ABA-mediated pathways and was further related to the yield and quality in cotton. PMID:25991739

  11. America's Service Academies, Your Service Academies

    ERIC Educational Resources Information Center

    Born, Dana H.; Phillips, Andrew T.; Trainor, Timothy E.

    2012-01-01

    The United States Air Force Academy, United States Naval Academy, and United States Military Academy are America's three largest service academies. They are "the" primary undergraduate institutions and commissioning sources that educate and develop the officers who are expected to lead this nation's armed forces. They are special places that have…

  12. The Timing of the Circadian Clock and Sleep Differ between Napping and Non-Napping Toddlers.

    PubMed

    Akacem, Lameese D; Simpkin, Charles T; Carskadon, Mary A; Wright, Kenneth P; Jenni, Oskar G; Achermann, Peter; LeBourgeois, Monique K

    2015-01-01

    The timing of the internal circadian clock shows large inter-individual variability across the lifespan. Although the sleep-wakefulness pattern of most toddlers includes an afternoon nap, the association between napping and circadian phase in early childhood remains unexplored. This study examined differences in circadian phase and sleep between napping and non-napping toddlers. Data were collected on 20 toddlers (34.2±2.0 months; 12 females; 15 nappers). Children followed their habitual napping and non-napping sleep schedules (monitored with actigraphy) for 5 days before an in-home salivary dim light melatonin onset (DLMO) assessment. On average, napping children fell asleep during their nap opportunities on 3.6±1.2 of the 5 days before the DLMO assessment. For these napping children, melatonin onset time was 38 min later (p = 0.044; d = 0.93), actigraphically-estimated bedtime was 43 min later (p = 0.014; d = 1.24), sleep onset time was 59 min later (p = 0.006; d = 1.46), and sleep onset latency was 16 min longer (p = 0.030; d = 1.03) than those not napping. Midsleep and wake time did not differ by napping status. No difference was observed in the bedtime, sleep onset, or midsleep phase relationships with DLMO; however, the wake time phase difference was 47 min smaller for napping toddlers (p = 0.029; d = 1.23). On average, nappers had 69 min shorter nighttime sleep durations (p = 0.006; d = 1.47) and spent 49 min less time in bed (p = 0.019; d = 1.16) than non-nappers. Number of days napping was correlated with melatonin onset time (r = 0.49; p = 0.014). Our findings indicate that napping influences individual variability in melatonin onset time in early childhood. The delayed bedtimes of napping toddlers likely permits light exposure later in the evening, thereby delaying the timing of the clock and sleep. Whether the early developmental trajectory of circadian phase involves an advance associated with the decline in napping is a question necessitating

  13. The Nap family proteins, CG5017/Hanabi and Nap1, are essential for Drosophila spermiogenesis.

    PubMed

    Kimura, Shuhei

    2013-04-01

    Spermiogenesis is a dynamic process leading to alterations in cell morphology. In spermiogenesis, the roles of the histone chaperones are largely unknown. Here, I report the unexpected roles of two Nap family proteins, CG5017/Hanabi and nucleosome assembly protein 1 (Nap1) in Drosophila. Hanabi is mainly localized in the cytoplasm, and the hanabi mutant shows fully scattered nuclei and abnormality of nuclear shaping in spermatid elongation. In contrast, Nap1 is localized at the apical tip of the sperm head, and the nap1 mutant exhibits disruption of the nuclear bundle in the later stage. These findings imply that Nap family proteins might individually sustain cytoskeleton-based morphogenesis, rather than histone biogenesis. PMID:23454210

  14. [Profile of the elderly who naps].

    PubMed

    dos Santos, Ariene Angelini; de Oliveira, Simone Camargo; Freitas, Denise Cuoghi de Carvalho Veríssimo; Ceolim, Maria Filomena; Pavarini, Sofia Cristina Iost; da Rocha, Maria Cecília Pires

    2013-12-01

    This study aimed to characterize the elderly who naps according to sociodemographic characteristics and frailty. A descriptive, cross-sectional study part of the multicenter project Frailty in the Elderly Brazilians. We evaluated 1,866 elderly people using a sociodemographic questionnaire. The frailty was assessed using the phenotype proposed by Fried. The data were analyzed with descriptive statistics. The results showed that the profile of the elderly who naps consists predominantly of women, married, retired, pre-frail, with an average age of 73 years, four years of study, with monthly family income of 3.9 minimum salary, with 4,4 children who were living with them only. The elderly reported napping on average 5.9 days per week, lasting 53.5 minutes per nap. Knowing the profile of the elderly who naps contributes to health professionals in the development of actions in relation to sleep problems of the frail/pre-frail elderly, preventing, minimizing or solving these problems. PMID:24626360

  15. NAPS: Network Analysis of Protein Structures

    PubMed Central

    Chakrabarty, Broto; Parekh, Nita

    2016-01-01

    Traditionally, protein structures have been analysed by the secondary structure architecture and fold arrangement. An alternative approach that has shown promise is modelling proteins as a network of non-covalent interactions between amino acid residues. The network representation of proteins provide a systems approach to topological analysis of complex three-dimensional structures irrespective of secondary structure and fold type and provide insights into structure-function relationship. We have developed a web server for network based analysis of protein structures, NAPS, that facilitates quantitative and qualitative (visual) analysis of residue–residue interactions in: single chains, protein complex, modelled protein structures and trajectories (e.g. from molecular dynamics simulations). The user can specify atom type for network construction, distance range (in Å) and minimal amino acid separation along the sequence. NAPS provides users selection of node(s) and its neighbourhood based on centrality measures, physicochemical properties of amino acids or cluster of well-connected residues (k-cliques) for further analysis. Visual analysis of interacting domains and protein chains, and shortest path lengths between pair of residues are additional features that aid in functional analysis. NAPS support various analyses and visualization views for identifying functional residues, provide insight into mechanisms of protein folding, domain-domain and protein–protein interactions for understanding communication within and between proteins. URL:http://bioinf.iiit.ac.in/NAPS/. PMID:27151201

  16. NAPS: Network Analysis of Protein Structures.

    PubMed

    Chakrabarty, Broto; Parekh, Nita

    2016-07-01

    Traditionally, protein structures have been analysed by the secondary structure architecture and fold arrangement. An alternative approach that has shown promise is modelling proteins as a network of non-covalent interactions between amino acid residues. The network representation of proteins provide a systems approach to topological analysis of complex three-dimensional structures irrespective of secondary structure and fold type and provide insights into structure-function relationship. We have developed a web server for network based analysis of protein structures, NAPS, that facilitates quantitative and qualitative (visual) analysis of residue-residue interactions in: single chains, protein complex, modelled protein structures and trajectories (e.g. from molecular dynamics simulations). The user can specify atom type for network construction, distance range (in Å) and minimal amino acid separation along the sequence. NAPS provides users selection of node(s) and its neighbourhood based on centrality measures, physicochemical properties of amino acids or cluster of well-connected residues (k-cliques) for further analysis. Visual analysis of interacting domains and protein chains, and shortest path lengths between pair of residues are additional features that aid in functional analysis. NAPS support various analyses and visualization views for identifying functional residues, provide insight into mechanisms of protein folding, domain-domain and protein-protein interactions for understanding communication within and between proteins. URL:http://bioinf.iiit.ac.in/NAPS/. PMID:27151201

  17. Nap-Dependent Learning in Infants

    ERIC Educational Resources Information Center

    Hupbach, Almut; Gomez, Rebecca L.; Bootzin, Richard R.; Nadel, Lynn

    2009-01-01

    Sleep has been shown to aid a variety of learning and memory processes in adults (Stickgold, 2005 ). Recently, we showed that infants' learning also benefits from subsequent sleep such that infants who nap are able to abstract the general grammatical pattern of a briefly presented artificial language (Gomez, Bootzin & Nadel, 2006 ). In the present…

  18. Napping after complex motor learning enhances juggling performance.

    PubMed

    Morita, Yuko; Ogawa, Keiko; Uchida, Sunao

    2016-01-01

    The present study examined whether a nap after complex motor learning enhanced the following day's physical performance. Eighteen volunteers met the inclusion criteria and were assigned to either a nap (n=9; men=5; mean age=21.0±1.5) or no-nap group (n=9; men=5; mean age=21.9±0.3). Participants practiced juggling in the morning and were tested immediately afterwards. Participants of the nap group were given a 70-minute nap opportunity after juggling practice, while the no-nap group stayed awake. Juggling performance was then tested in the evening (retest-1) and the next morning (retest-2). Two-way analysis of variance (group: nap, no-nap×time: test, retest-1, retest-2) found there was a significant effect of test time and a significant group×time interaction. The juggling performance of both groups improved from test to retest-1, respectively. However, the juggling performance level of the nap group was higher than that of the no-nap group at the retest-1. As predicted, a nap promptly after learning motor skills was associated with subsequently improved performance. Moreover, the juggling performance of the nap group showed additional significant improvements in the retest-2. In the no-nap group, however, there were no significant improvements in the juggling performance after nocturnal sleep. These results demonstrate that the benefits of a nap following learning were further enhanced after nocturnal sleep. The present results may provide justification for introducing nap periods into daily athletic training as an active method to improve performance. PMID:27656276

  19. Sleep spindles in midday naps enhance learning in preschool children.

    PubMed

    Kurdziel, Laura; Duclos, Kasey; Spencer, Rebecca M C

    2013-10-22

    Despite the fact that midday naps are characteristic of early childhood, very little is understood about the structure and function of these sleep bouts. Given that sleep benefits memory in young adults, it is possible that naps serve a similar function for young children. However, children transition from biphasic to monophasic sleep patterns in early childhood, eliminating the nap from their daily sleep schedule. As such, naps may contain mostly light sleep stages and serve little function for learning and memory during this transitional age. Lacking scientific understanding of the function of naps in early childhood, policy makers may eliminate preschool classroom nap opportunities due to increasing curriculum demands. Here we show evidence that classroom naps support learning in preschool children by enhancing memories acquired earlier in the day compared with equivalent intervals spent awake. This nap benefit is greatest for children who nap habitually, regardless of age. Performance losses when nap-deprived are not recovered during subsequent overnight sleep. Physiological recordings of naps support a role of sleep spindles in memory performance. These results suggest that distributed sleep is critical in early learning; when short-term memory stores are limited, memory consolidation must take place frequently. PMID:24062429

  20. Sleep spindles in midday naps enhance learning in preschool children

    PubMed Central

    Kurdziel, Laura; Duclos, Kasey; Spencer, Rebecca M. C.

    2013-01-01

    Despite the fact that midday naps are characteristic of early childhood, very little is understood about the structure and function of these sleep bouts. Given that sleep benefits memory in young adults, it is possible that naps serve a similar function for young children. However, children transition from biphasic to monophasic sleep patterns in early childhood, eliminating the nap from their daily sleep schedule. As such, naps may contain mostly light sleep stages and serve little function for learning and memory during this transitional age. Lacking scientific understanding of the function of naps in early childhood, policy makers may eliminate preschool classroom nap opportunities due to increasing curriculum demands. Here we show evidence that classroom naps support learning in preschool children by enhancing memories acquired earlier in the day compared with equivalent intervals spent awake. This nap benefit is greatest for children who nap habitually, regardless of age. Performance losses when nap-deprived are not recovered during subsequent overnight sleep. Physiological recordings of naps support a role of sleep spindles in memory performance. These results suggest that distributed sleep is critical in early learning; when short-term memory stores are limited, memory consolidation must take place frequently. PMID:24062429

  1. The Napping Company: bringing science to the workplace.

    PubMed

    Anthony, William A; Anthony, Camille W

    2005-01-01

    Increasing emphasis is currently being given to the importance of bringing knowledge gained from science into places where people live and work, in order to increase the impact science has on the general public's quality of life. Scientific findings about the positive impact of napping on mood and performance are an example of research generated knowledge that needs to be brought to the workplace. A major goal of the Napping Company (www.napping.com) is to bring the science of napping to the workers and the workplace so that employees and employers can act on this knowledge and change worker napping behavior and employer napping policies. The present paper overviews the challenges inherent in making scientific knowledge useful to how we live our lives. The Napping Company is guided by five principles of knowledge transfer in the company's attempts to disseminate and increase utilization of napping research. Examples are given to illustrate how the Napping Company has used these principles to bridge the gap between napping science and nap behavior and policies in the workplace.

  2. National Academy of Sciences

    MedlinePlus

    ... Read More » Proceedings of the National Academy of Sciences (PNAS) PNAS is one of the world’s most- ... Exchange Evolution Resources Biographical Memoirs National Academy of Sciences About The NAS Mission History Organization Leadership and ...

  3. Why a Steiner Academy?

    ERIC Educational Resources Information Center

    Avison, Kevin

    2008-01-01

    This article examines the curious position of the Academy model in the English school system and how a potential Hereford Steiner Waldorf Academy might figure in this. It sketches the background to the Steiner movement in the UK and goes on to set out the key aspirations and concerns of Steiner educators regarding an Academy. The article provides…

  4. Career Academy Course Sequences.

    ERIC Educational Resources Information Center

    Markham, Thom; Lenz, Robert

    This career academy course sequence guide is designed to give teachers a quick overview of the course sequences of well-known career academy and career pathway programs from across the country. The guide presents a variety of sample course sequences for the following academy themes: (1) arts and communication; (2) business and finance; (3)…

  5. Academies and School Diversity

    ERIC Educational Resources Information Center

    Curtis, Andrew

    2009-01-01

    This article considers the implications of Academies for the diversity of schooling in England. It seeks to establish the extent to which Academies are distinctive compared to other types of state secondary schools and whether this has been affected by a number of recent reforms. Different types of Academies are also be examined. Previous work in…

  6. Promoting alertness with a short nap during a night shift.

    PubMed

    Sallinen, M; Härmä, M; Akerstedt, T; Rosa, R; Lillqvist, O

    1998-12-01

    The use of a short (< 1 h) nap in improving alertness during the early morning hours in the first night shift was examined under laboratory conditions. The study contained four experimental, non-consecutive night shifts with a nap of either 50 or 30 min at 01.00 or 04.00 hours. An experimental night shift without a nap served as a control condition. Each experimental shift was followed by daytime sleep. Fourteen experienced male shift workers went through all of the experimental conditions. The results showed that the naps improved the ability to respond to visual signals during the second half of the night shift. Physiological sleepiness was alleviated by the early naps, as measured 50 min after awakening, but not at the end of the shift. Subjective sleepiness was somewhat decreased by the naps. The naps produced sleep inertia which lasted for about 10-15 min. Daytime sleep was somewhat impaired by the 50 min naps. The study shows that a nap shorter than 1 h is able to improve alertness to a certain extent during the first night shift.

  7. Nap sleep spindle correlates of intelligence

    PubMed Central

    Ujma, Péter P.; Bódizs, Róbert; Gombos, Ferenc; Stintzing, Johannes; Konrad, Boris N.; Genzel, Lisa; Steiger, Axel; Dresler, Martin

    2015-01-01

    Sleep spindles are thalamocortical oscillations in non-rapid eye movement (NREM) sleep, that play an important role in sleep-related neuroplasticity and offline information processing. Several studies with full-night sleep recordings have reported a positive association between sleep spindles and fluid intelligence scores, however more recently it has been shown that only few sleep spindle measures correlate with intelligence in females, and none in males. Sleep spindle regulation underlies a circadian rhythm, however the association between spindles and intelligence has not been investigated in daytime nap sleep so far. In a sample of 86 healthy male human subjects, we investigated the correlation between fluid intelligence and sleep spindle parameters in an afternoon nap of 100 minutes. Mean sleep spindle length, amplitude and density were computed for each subject and for each derivation for both slow and fast spindles. A positive association was found between intelligence and slow spindle duration, but not any other sleep spindle parameter. As a positive correlation between intelligence and slow sleep spindle duration in full-night polysomnography has only been reported in females but not males, our results suggest that the association between intelligence and sleep spindles is more complex than previously assumed. PMID:26607963

  8. Nap sleep spindle correlates of intelligence.

    PubMed

    Ujma, Péter P; Bódizs, Róbert; Gombos, Ferenc; Stintzing, Johannes; Konrad, Boris N; Genzel, Lisa; Steiger, Axel; Dresler, Martin

    2015-11-26

    Sleep spindles are thalamocortical oscillations in non-rapid eye movement (NREM) sleep, that play an important role in sleep-related neuroplasticity and offline information processing. Several studies with full-night sleep recordings have reported a positive association between sleep spindles and fluid intelligence scores, however more recently it has been shown that only few sleep spindle measures correlate with intelligence in females, and none in males. Sleep spindle regulation underlies a circadian rhythm, however the association between spindles and intelligence has not been investigated in daytime nap sleep so far. In a sample of 86 healthy male human subjects, we investigated the correlation between fluid intelligence and sleep spindle parameters in an afternoon nap of 100 minutes. Mean sleep spindle length, amplitude and density were computed for each subject and for each derivation for both slow and fast spindles. A positive association was found between intelligence and slow spindle duration, but not any other sleep spindle parameter. As a positive correlation between intelligence and slow sleep spindle duration in full-night polysomnography has only been reported in females but not males, our results suggest that the association between intelligence and sleep spindles is more complex than previously assumed.

  9. Napping facilitates word learning in early lexical development.

    PubMed

    Horváth, Klára; Myers, Kyle; Foster, Russell; Plunkett, Kim

    2015-10-01

    Little is known about the role that night-time sleep and daytime naps play in early cognitive development. Our aim was to investigate how napping affects word learning in 16-month-olds. Thirty-four typically developing infants were assigned randomly to nap and wake groups. After teaching two novel object-word pairs to infants, we tested their initial performance with an intermodal preferential looking task in which infants are expected to increase their target looking time compared to a distracter after hearing its auditory label. A second test session followed after approximately a 2-h delay. The delay contained sleep for the nap group or no sleep for the wake group. Looking behaviour was measured with an automatic eye-tracker. Vocabulary size was assessed using the Oxford Communicative Development Inventory. A significant interaction between group and session was found in preferential looking towards the target picture. The performance of the nap group increased after the nap, whereas that of the wake group did not change. The gain in performance correlated positively with the expressive vocabulary size in the nap group. These results indicate that daytime napping helps consolidate word learning in infancy. PMID:25950233

  10. Napping in College Students and Its Relationship with Nighttime Sleep

    ERIC Educational Resources Information Center

    Ye, Lichuan; Hutton Johnson, Stacy; Keane, Kathleen; Manasia, Michael; Gregas, Matt

    2015-01-01

    Objective: To examine the habit of napping and its relationship with nighttime sleep in college students. Participants: Four hundred and forty undergraduate students who responded to an anonymous online survey in April 2010. Methods: Three questions were asked to determine the frequency, length, and timing of napping during the past month. Sleep…

  11. Talent Management in Academies

    ERIC Educational Resources Information Center

    Davies, Brent; Davies, Barbara J.

    2010-01-01

    Purpose: Academies are semi-autonomous schools set up outside the normal local government structures with sponsors from business and charity groups to create new and innovative ways of creating and sustaining school transformation. The aim of this paper is to assist in a strategic conversation within the academy movement on talent development.…

  12. Researching Academies in England

    ERIC Educational Resources Information Center

    Gunter, Helen; Woods, Philip; Woods, Glenys

    2008-01-01

    In 2002 the New Labour government launched the Academies programme (known initially as City Academies) with the target of 400, of which 200 are to opened by 2010. The espoused aim has been to tackle underachievement and encourage diversity of provision. However, it continues to be a controversial policy that is being driven by the Specialist…

  13. Physiological and evolutionary studies of NAP systems in Shewanella piezotolerans WP3

    PubMed Central

    Chen, Ying; Wang, Fengping; Xu, Jun; Mehmood, Muhammad Aamer; Xiao, Xiang

    2011-01-01

    Most of the Shewanella species contain two periplasmic nitrate reductases (NAP-α and NAP-β), which is a unique feature of this genus. In the present study, the physiological function and evolutionary relationship of the two NAP systems were studied in the deep-sea bacterium Shewanella piezotolerans WP3. Both of the WP3 nap gene clusters: nap-α (napD1A1B1C) and nap-β (napD2A2B2) were shown to be involved in nitrate respiration. Phylogenetic analyses suggest that NAP-β originated earlier than NAP-α. Tetraheme cytochromes NapC and CymA were found to be the major electron deliver proteins, and CymA also served as a sole electron transporter towards nitrite reductase. Interestingly, a ΔnapA2 mutant with the single functional NAP-α system showed better growth than the wild-type strain, when grown in nitrate medium, and it had a selective advantage to the wild-type strain. On the basis of these results, we proposed the evolution direction of nitrate respiration system in Shewanella: from a single NAP-β to NAP-β and NAP-α both, followed by the evolution to a single NAP-α. Moreover, the data presented here will be very useful for the designed engineering of Shewanella for more efficient respiring capabilities for environmental bioremediation. PMID:21124486

  14. The use of caffeine versus prophylactic naps in sustained performance.

    PubMed

    Bonnet, M H; Gomez, S; Wirth, O; Arand, D L

    1995-02-01

    Previous studies have shown that performance during sleep loss is improved by prophylactic naps as a function of varying nap length. Based on single-dose caffeine studies, a similar dose-response effect has been hypothesized on performance, alertness and mood during sleep loss. The present study compared the effects of repeated versus single-dose administration of caffeine and varying amounts of sleep taken prior to sleep loss on performance, mood and physiological measures during 2 nights and days of sleep loss. A total of 140 normal, young adult males participated at one of two study sites. Ninety-eight subjects at one site were randomly assigned to one of four nap conditions (0, 2, 4 or 8 hours) and 42 subjects at the second site were assigned to one of four caffeine conditions. After a normal baseline night of sleep and morning baseline tests of performance, mood and nap latency, subjects in the nap groups returned to bed at noon, 1600 hours, 1800 hours or not at all. Bedtimes were varied so that all naps ended at 2000 hours. Subjects in the caffeine groups received either a single 400-mg dose of caffeine at 0130 hours each night or repeated doses of 150 or 300 mg every 6 hours starting at 0130 hours on the 1st night of sleep loss. A placebo control group (no nap and placebo administered every 6 hours on the repeated caffeine schedule) was run at both sites.(ABSTRACT TRUNCATED AT 250 WORDS)

  15. A 30-Minute, but Not a 10-Minute Nighttime Nap is Associated with Sleep Inertia

    PubMed Central

    Hilditch, Cassie J.; Centofanti, Stephanie A.; Dorrian, Jillian; Banks, Siobhan

    2016-01-01

    Study Objectives: To assess sleep inertia following 10-min and 30-min naps during a simulated night shift. Methods: Thirty-one healthy adults (aged 21–35 y; 18 females) participated in a 3-day laboratory study that included one baseline (BL) sleep (22:00–07:00) and one experimental night involving randomization to either: total sleep deprivation (NO-NAP), a 10-min nap (10-NAP) or a 30-min nap (30-NAP). Nap opportunities ended at 04:00. A 3-min psychomotor vigilance task (PVT-B), digit-symbol substitution task (DSST), fatigue scale, sleepiness scale, and self-rated performance scale were undertaken pre-nap (03:00) and at 2, 17, 32, and 47 min post-nap. Results: The 30-NAP (14.7 ± 5.7 min) had more slow wave sleep than the 10-NAP (0.8 ± 1.5 min; P < 0.001) condition. In the NO-NAP condition, PVT-B performance was worse than pre-nap (4.6 ± 0.3 1/sec) at 47 min post-nap (4.1 ± 0.4 1/sec; P < 0.001). There was no change across time in the 10-NAP condition. In the 30-NAP condition, performance immediately deteriorated from pre-nap (4.3 ± 0.3 1/sec) and was still worse at 47 min post-nap (4.0 ± 0.5 1/sec; P < 0.015). DSST performance deteriorated in the NO-NAP (worse than pre-nap from 17 to 47 min; P < 0.008), did not change in the 10-NAP, and was impaired 2 min post-nap in the 30-NAP condition (P = 0.028). All conditions self-rated performance as better than pre-nap for all post-nap test points (P < 0.001). Conclusions: This study is the first to show that a 10-min (but not a 30-min) nighttime nap had minimal sleep inertia and helped to mitigate short-term performance impairment during a simulated night shift. Self-rated performance did not reflect objective performance following a nap. Citation: Hilditch CJ, Centofanti SA, Dorrian J, Banks S. A 30-minute, but not a 10-minute nighttime nap is associated with sleep inertia. SLEEP 2016;39(3):675–685. PMID:26715234

  16. Electron transport to periplasmic nitrate reductase (NapA) of Wolinella succinogenes is independent of a NapC protein.

    PubMed

    Simon, Jörg; Sänger, Monica; Schuster, Stephan C; Gross, Roland

    2003-07-01

    The rumen bacterium Wolinella succinogenes grows by respiratory nitrate ammonification with formate as electron donor. Whereas the enzymology and coupling mechanism of nitrite respiration is well known, nitrate reduction to nitrite has not yet been examined. We report here that intact cells and cell fractions catalyse nitrate and chlorate reduction by reduced viologen dyes with high specific activities. A gene cluster encoding components of a putative periplasmic nitrate reductase system (napA, G, H, B, F, L, D) was sequenced. The napA gene was inactivated by inserting a kanamycin resistance gene cassette. The resulting mutant did not grow by nitrate respiration and did not reduce nitrate during growth by fumarate respiration, in contrast to the wild type. An antigen was detected in wild-type cells using an antiserum raised against the periplasmic nitrate reductase (NapA) from Paracoccus pantotrophus. This antigen was absent in the W. succinogenes napA mutant. It is concluded that the periplasmic nitrate reductase NapA is the only respiratory nitrate reductase in W. succinogenes, although a second nitrate-reducing enzyme is apparently induced in the napA mutant. The nap cluster of W. succinogenes lacks a napC gene whose product is thought to function in quinol oxidation and electron transfer to NapA in other bacteria. The W. succinogenes genome encodes two members of the NapC/NirT family, NrfH and FccC. Characterization of corresponding deletion mutants indicates that neither of these two proteins is required for nitrate respiration. A mutant lacking the genes encoding respiratory nitrite reductase (nrfHA) had wild-type properties with respect to nitrate respiration. A model of the electron transport chain of nitrate respiration is proposed in which one or more of the napF, G, H and L gene products mediate electron transport from menaquinol to the periplasmic NapAB complex. Inspection of the W. succinogenes genome sequence suggests that ammonia formation from

  17. Reduction of Nitrate in Shewanella oneidensis depends on atypical NAP and NRF systems with NapB as a preferred electron transport protein from CymA to NapA

    SciTech Connect

    Gao, Haichun; Yang, Zamin; Barua, Soumitra; Reed, Samantha B.; Romine, Margaret F.; Nealson, Kenneth H.; Fredrickson, Jim K.; Tiedje, James M.; Zhou, Jizhong

    2009-04-23

    In the genome of Shewanella oneidensis, a napDAGHB gene cluster encoding periplasmic nitrate reductase (NapA) and accessory proteins and an nrfA gene encoding periplasmic nitrite reductase (NrfA) have been identified. These two systems seem to be atypical because the genome lacks genes encoding cytoplasmic membrane electron transport proteins, NapC for NAP and NrfBCD/NrfH for NRF, respectively. Here, we present evidence that reduction of nitrate to ammonium in S. oneidensis is carried out by these atypical systems in a two-step manner. Transcriptional and mutational analyses suggest that CymA, a cytoplasmic membrane electron transport protein, is likely to be the functional replacement of both NapC and NrfH in S. oneidensis. Surprisingly, a strain devoid of napB encoding the small subunit of nitrate reductase exhibited the maximum cell density sooner than the wild type. Further characterization of this strain showed that nitrite was not detected as a free intermediate in its culture and NapB provides a fitness gain for S. oneidensis to compete for nitrate in the environments. On the basis results from mutational analyses of napA, napB, nrfA and napBnrfA in-frame deletion mutants, we propose that NapB is able to favor nitrate reduction by routing electrons to NapA exclusively.

  18. Photocopy of original nap (from feeder book), New York State ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of original nap (from feeder book), New York State Archives and Manuscripts, Albany, New York), Holnes Hutchinson, surveyor, 1834 - Glens Falls Feeder, Sluice, Along south side of Glens Falls Feeder between locks 10 & 20, Hudson Falls, Washington County, NY

  19. Practice and nap schedules modulate children's motor learning.

    PubMed

    Ren, Jie; Guo, Wei; Yan, Jin H; Liu, Guanmin; Jia, Fujun

    2016-01-01

    Night- or day-time sleep enhances motor skill acquisition. However, prominent issues remained about the circadian (time-of-day) and homeostatic (time since last sleep) effects of sleep on developmental motor learning. Therefore, we examined the effects of nap schedules and nap-test-intervals (NTIs) on the learning of finger tapping sequences on computer keyboards. Children aged 6-7, 8-9, and 10-11 years explicitly acquired the short and long tapping orders that share the same movement strings (4-2-3-1-4, 4-2-3-1-4-2-3-1-4). Following a constant 8- or 10-hr post-learning period in one of the four NTIs (2, 4, 5, 7 hr), children in the morning napping groups, the afternoon napping groups, or the waking group performed the original long sequence in retention test (4-2-3-1-4-2-3-1-4) and the mirrored-order sequence in transfer test (1-3-2-4-1-3-2-4-1). Age and treatment differences in the movement time (MT, ms) and sequence accuracy (SA, %) were compared during skill learning and in retrieval tests. Results suggest that practice or nap affects MT and SA in a greater extent for the younger learners than for the older learners. The circadian effects might not change nap-based skill learning. Importantly, the longer NTIs resulted in superior retention performance than the shorter ones, suggesting that children require a relatively longer post-nap period to form motor memory. Finally, nap-based motor learning was more marked in skill retention than in skill transfer. Brain development may play an important role in motor learning. Our discussion centers on memory consolidation and its relevance for skill acquisition from early to late childhood. PMID:26582507

  20. Practice and nap schedules modulate children's motor learning.

    PubMed

    Ren, Jie; Guo, Wei; Yan, Jin H; Liu, Guanmin; Jia, Fujun

    2016-01-01

    Night- or day-time sleep enhances motor skill acquisition. However, prominent issues remained about the circadian (time-of-day) and homeostatic (time since last sleep) effects of sleep on developmental motor learning. Therefore, we examined the effects of nap schedules and nap-test-intervals (NTIs) on the learning of finger tapping sequences on computer keyboards. Children aged 6-7, 8-9, and 10-11 years explicitly acquired the short and long tapping orders that share the same movement strings (4-2-3-1-4, 4-2-3-1-4-2-3-1-4). Following a constant 8- or 10-hr post-learning period in one of the four NTIs (2, 4, 5, 7 hr), children in the morning napping groups, the afternoon napping groups, or the waking group performed the original long sequence in retention test (4-2-3-1-4-2-3-1-4) and the mirrored-order sequence in transfer test (1-3-2-4-1-3-2-4-1). Age and treatment differences in the movement time (MT, ms) and sequence accuracy (SA, %) were compared during skill learning and in retrieval tests. Results suggest that practice or nap affects MT and SA in a greater extent for the younger learners than for the older learners. The circadian effects might not change nap-based skill learning. Importantly, the longer NTIs resulted in superior retention performance than the shorter ones, suggesting that children require a relatively longer post-nap period to form motor memory. Finally, nap-based motor learning was more marked in skill retention than in skill transfer. Brain development may play an important role in motor learning. Our discussion centers on memory consolidation and its relevance for skill acquisition from early to late childhood.

  1. Arabidopsis NAP1 Regulates the Formation of Autophagosomes.

    PubMed

    Wang, Pengwei; Richardson, Christine; Hawes, Chris; Hussey, Patrick J

    2016-08-01

    The SCAR/WAVE complex is required for ARP2/3-mediated actin nucleation, and these complexes are highly conserved in plants and animals [1, 2]. Proteins from the SCAR/WAVE complex have been found to be membrane associated in plants [3]. Using fluorescent protein fusions, we have found that NAP1 [4], a component of the SCAR/WAVE complex, locates to vesicles or puncta that appear upon applied pressure. These NAP1 vesicles can be endoplasmic reticulum (ER)-associated, can co-align with the cytoskeleton, and fuse to each other homotypically. More interestingly, the majority co-localizes with the autophagosome marker ATG8, and anti-NAP1 identifies autophagosomes in immuno-TEM. Macroautophagy (hereafter referred to as autophagy) is enhanced under certain stress conditions such as nitrogen starvation and salt stress. We show that fewer autophagosomes are generated in the NAP1 knockout mutant during starvation stress. The nap1 mutant (and KO mutants of other components of the SCAR/WAVE and ARP2/3 complexes) is more susceptible to nitrogen starvation and is less salt tolerant, indicating defective autophagy. In conclusion, our data show that NAP1 has another function in plant cells, and that is as a regulator of autophagy. PMID:27451899

  2. Involvement of Nucleocytoplasmic Shuttling of Yeast Nap1 in Mitotic Progression

    PubMed Central

    Miyaji-Yamaguchi, Mary; Kato, Kohsuke; Nakano, Ryosuke; Akashi, Tomohiro; Kikuchi, Akihiko; Nagata, Kyosuke

    2003-01-01

    Nucleosome assembly protein 1 (Nap1) is widely conserved from yeasts to humans and facilitates nucleosome formation in vitro as a histone chaperone. Nap1 is generally localized in the cytoplasm, except that subcellular localization of Drosophila melanogaster Nap1 is dynamically regulated between the cytoplasm and nucleus during early development. The cytoplasmic localization of Nap1 is seemingly incompatible with the proposed role of Nap1 in nucleosome formation, which should occur in the nucleus. Here, we have examined the roles of a putative nuclear export signal (NES) sequence in yeast Nap1 (yNap1). yNap1 mutants lacking the NES-like sequence were localized predominantly in the nucleus. Deletion of NAP1 in cells harboring a single mitotic cyclin gene is known to cause mitotic delay and temperature-sensitive growth. A wild-type NAP1 complemented these phenotypes while nap1 mutant genes lacking the NES-like sequence or carboxy-terminal region did not. These and other results suggest that yNap1 is a nucleocytoplasmic shuttling protein and that its shuttling is important for yNap1 function during mitotic progression. This study also provides a possible explanation for Nap1's involvement in nucleosome assembly and/or remodeling in the nucleus. PMID:12944491

  3. Free Schools and Academies

    ERIC Educational Resources Information Center

    Eades, Jane

    2014-01-01

    The number and range of problems associated with academies and "free" schools is worrying and can be attributed to the lack of ability of central Government to oversee the increasingly fragmented education provision. In this article, the author looks at just a few of those problems which have been reported since she started to log them…

  4. Legends of the Academy

    ERIC Educational Resources Information Center

    Hernandez, Arelis

    2009-01-01

    For this special edition on "Higher Education Careers," "Diverse" caught up with some legends whose careers have made an indelible impact on the academy. "Diverse" found that even in retirement, or semi-retirement, these pioneers never venture far from the passions that made them great educators and diversity advocates. This article features four…

  5. Valor Collegiate Academies

    ERIC Educational Resources Information Center

    EDUCAUSE, 2015

    2015-01-01

    The four guiding principles behind the blended, competency-based, personalized learning model of Valor Collegiate Academies, a charter organization serving grades 5-12 in Nashville, TN: (1) Reflect the diversity of both our country and local community; (2) Personalize a student's experience to meet his/her unique academic and non-academic needs;…

  6. Dual Enrollment Academy Programs

    ERIC Educational Resources Information Center

    Gonzalez, Nicolas; Chavez, Guadalupe

    2009-01-01

    Dual Enrollment Engineering (DEEA) and Medical Science (DEMSA) Academies are two-year dual enrollment programs for high school students. Students explore engineering and medical careers through college coursework. Students prepare for higher education in engineering and medical fields while completing associate degrees in biology or engineering…

  7. Benjamin Franklin Street Academy.

    ERIC Educational Resources Information Center

    Wohl, Seth F.

    In this evaluation report of the sixth year of operation of the Benjamin Franklin-Urban League Street Academy in New York City, it is recommended that the program be continued for the seventh year despite the poorer than expected student gains in all studied components and the sporadic student attendance pattern and high dropout rate. Students…

  8. Academy Engages Incarcerated Youths

    ERIC Educational Resources Information Center

    Zehr, Mary Ann

    2010-01-01

    It's not easy to keep young people on task for learning in a youth prison, but David Domenici, the principal of the Maya Angelou Academy, a charter-like school serving incarcerated juveniles, is trying to do it while at the same time creating a model program for improving educational services for young offenders. Located at the New Beginnings…

  9. Brightside Academy: Pittsburgh, Pennsylvania

    ERIC Educational Resources Information Center

    Horn, Sarah

    2009-01-01

    Since its inception in 1992, Brightside Academy has been providing quality care to children six weeks to 12 years old. Operating 49 locations in Pennsylvania, Ohio, and New York, the company is committed to strengthening learners and respecting families. Currently, the organization provides early education for 6,700 children on a daily basis. 90%…

  10. American Academy of Forensic Sciences

    MedlinePlus

    ... American Society of Forensic Odontology Research Grants Academy Standards Board (ASB) Account ... The American Academy of Forensic Sciences is a multi-disciplinary professional organization that provides leadership to advance ...

  11. Molecular evolution and species-specific expansion of the NAP members in plants.

    PubMed

    Fan, Kai; Shen, Hao; Bibi, Noreen; Li, Feng; Yuan, Shuna; Wang, Ming; Wang, Xuede

    2015-08-01

    The NAP (NAC-Like, Activated by AP3 /PI) subfamily is one of the important plant-specific transcription factors, and controls many vital biological processes in plants. In the current study, 197 NAP proteins were identified from 31 vascular plants, but no NAP members were found in eight non-vascular plants. All NAP proteins were phylogenetically classified into two groups (NAP I and NAP II), and the origin time of the NAP I group might be relatively later than that of the NAP II group. Furthermore, species-specific gene duplications, caused by segmental duplication events, resulted in the expansion of the NAP subfamily after species-divergence. Different groups have different expansion rates, and the NAP group preference was found during the expansion in plants. Moreover, the expansion of NAP proteins may be related to the gain and loss of introns. Besides, functional divergence was limited after the gene duplication. Abscisic acid (ABA) might play an important role in leaf senescence, which is regulated by NAP subfamily. These results could lay an important foundation for expansion and evolutionary analysis of NAP subfamily in plants.

  12. Use of NAP gene to manipulate leaf senescence in plants

    DOEpatents

    Gan, Susheng; Guo, Yongfeng

    2013-04-16

    The present invention discloses transgenic plants having an altered level of NAP protein compared to that of a non-transgenic plant, where the transgenic plants display an altered leaf senescence phenotype relative to a non-transgenic plant, as well as mutant plants comprising an inactivated NAP gene, where mutant plants display a delayed leaf senescence phenotype compared to that of a non-mutant plant. The present invention also discloses methods for delaying leaf senescence in a plant, as well as methods of making a mutant plant having a decreased level of NAP protein compared to that of a non-mutant plant, where the mutant plant displays a delayed leaf senescence phenotype relative to a non-mutant plant. Methods for causing precocious leaf senescence or promoting leaf senescence in a plant are also disclosed. Also disclosed are methods of identifying a candidate plant suitable for breeding that displays a delayed leaf senescence and/or enhanced yield phenotype.

  13. Academy of General Dentistry

    MedlinePlus

    ... Meeting & Exhibits PACE Contact Us Advocacy Hot Issues Government Relations Take Action Resources/Policies AGD Advocacy Fund Contact Us Publications & Media Publications Self-Instruction Social Media Press Room Contact Us Patient Resources Find an ...

  14. Calar Alto Academy

    NASA Astrophysics Data System (ADS)

    Pedraz, Santos; Galadí, David

    Calar Alto Academy was initiated in 2007 with the aim to give students from different Spanish universities the chance to perform professional observational work at Calar Alto Observatory. The second edition of this innovative educational project has increased the number of participating universities and has almost doubled the quantity of visiting students, in a significant step towards the consolidation of this undergraduate and graduate school of observational astronomy.

  15. Press Start

    NASA Astrophysics Data System (ADS)

    Harteveld, Casper

    This level sets the stage for the design philosophy called “Triadic Game Design” (TGD). This design philosophy can be summarized with the following sentence: it takes two to tango, but it takes three to design a meaningful game or a game with a purpose. Before the philosophy is further explained, this level will first delve into what is meant by a meaningful game or a game with a purpose. Many terms and definitions have seen the light and in this book I will specifically orient at digital games that aim to have an effect beyond the context of the game itself. Subsequently, a historical overview is given of the usage of games with a serious purpose which starts from the moment we human beings started to walk on our feet till our contemporary society. It turns out that we have been using games for all kinds of non-entertainment purposes for already quite a long time. With this introductory material in the back of our minds, I will explain the concept of TGD by means of a puzzle. After that, the protagonist of this book, the game Levee Patroller, is introduced. Based on the development of this game, the idea of TGD, which stresses to balance three different worlds, the worlds of Reality, Meaning, and Play, came into being. Interested? Then I suggest to quickly “press start!”

  16. Nap Schedules and Sleep Practices in Infant-Toddler Groups.

    ERIC Educational Resources Information Center

    Siren-Tiusanen, Helena; Robinson, Helja Antola

    2001-01-01

    Analyzed sleep-wake schedules and nap times in multiage infant-toddler groups through three case studies in Finnish day care centers. Found complex interactions among family daily patterns, day care patterns, and young children's sleep disturbances. Identified major differences in day care practices regarding sleep quality related to timing,…

  17. Nap1 regulates proper CENP-B binding to nucleosomes.

    PubMed

    Tachiwana, Hiroaki; Miya, Yuta; Shono, Nobuaki; Ohzeki, Jun-ichirou; Osakabe, Akihisa; Otake, Koichiro; Larionov, Vladimir; Earnshaw, William C; Kimura, Hiroshi; Masumoto, Hiroshi; Kurumizaka, Hitoshi

    2013-03-01

    CENP-B is a widely conserved centromeric satellite DNA-binding protein, which specifically binds to a 17-bp DNA sequence known as the CENP-B box. CENP-B functions positively in the de novo assembly of centromeric nucleosomes, containing the centromere-specific histone H3 variant, CENP-A. At the same time, CENP-B also prevents undesired assembly of the CENP-A nucleosome through heterochromatin formation on satellite DNA integrated into ectopic sites. Therefore, improper CENP-B binding to chromosomes could be harmful. However, no CENP-B eviction mechanism has yet been reported. In the present study, we found that human Nap1, an acidic histone chaperone, inhibited the non-specific binding of CENP-B to nucleosomes and apparently stimulated CENP-B binding to its cognate CENP-B box DNA in nucleosomes. In human cells, the CENP-B eviction activity of Nap1 was confirmed in model experiments, in which the CENP-B binding to a human artificial chromosome or an ectopic chromosome locus bearing CENP-B boxes was significantly decreased when Nap1 was tethered near the CENP-B box sequence. In contrast, another acidic histone chaperone, sNASP, did not promote CENP-B eviction in vitro and in vivo and did not stimulate specific CENP-B binding to CENP-A nucleosomes in vitro. We therefore propose a novel mechanism of CENP-B regulation by Nap1. PMID:23325853

  18. Electrocatalytic reduction of nitrate and selenate by NapAB.

    PubMed

    Gates, Andrew J; Butler, Clive S; Richardson, David J; Butt, Julea N

    2011-01-01

    Bacterial cellular metabolism is renowned for its metabolic diversity and adaptability. However, certain environments present particular challenges. Aerobic metabolism of highly reduced carbon substrates by soil bacteria such as Paracoccus pantotrophus presents one such challenge since it may result in excessive electron delivery to the respiratory redox chain when compared with the availability of terminal oxidant, O2. The level of a periplasmic ubiquinol-dependent nitrate reductase, NAP, is up-regulated in the presence of highly reduced carbon substrates. NAP oxidizes ubiquinol at the periplasmic face of the cytoplasmic membrane and reduces nitrate in the periplasm. Thus its activity counteracts the accumulation of excess reducing equivalents in ubiquinol, thereby maintaining the redox poise of the ubiquinone/ubiquinol pool without contributing to the protonmotive force across the cytoplasmic membrane. Although P. pantotrophus NapAB shows a high level of substrate specificity towards nitrate, the enzyme has also been reported to reduce selenate in spectrophotometric solution assays. This transaction draws on our current knowledge concerning the bacterial respiratory nitrate reductases and extends the application of PFE (protein film electrochemistry) to resolve and quantify the selenate reductase activity of NapAB. PMID:21265780

  19. Delayed benefit of naps on motor learning in preschool children.

    PubMed

    Desrochers, Phillip C; Kurdziel, Laura B F; Spencer, Rebecca M C

    2016-03-01

    Sleep benefits memory consolidation across a variety of domains in young adults. However, while declarative memories benefit from sleep in young children, such improvements are not consistently seen for procedural skill learning. Here we examined whether performance improvements on a procedural task, although not immediately observed, are evident after a longer delay when augmented by overnight sleep (24 h after learning). We trained 47 children, aged 33-71 months, on a serial reaction time task and, using a within-subject design, evaluated performance at three time points: immediately after learning, after a daytime nap (nap condition) or equivalent wake opportunity (wake condition), and 24 h after learning. Consistent with previous studies, performance improvements following the nap did not differ from performance improvements following an equivalent interval spent awake. However, significant benefits of the nap were found when performance was assessed 24 h after learning. This research demonstrates that motor skill learning is benefited by sleep, but that this benefit is only evident after an extended period of time.

  20. Types of Primary Insomnia: Is Hyperarousal Also Present during Napping?

    PubMed Central

    Pérusse, Alexandra D.; Turcotte, Isabelle; St-Jean, Geneviève; Ellis, Jason; Hudon, Carol; Bastien, Célyne H.

    2013-01-01

    Study Objectives: The objective of this study was to identify if hyperarousal is a 24-hour phenomenon in insomnia by comparing sleep during napping between good sleepers (GS) and Insomnia sufferers (INS) (subdivided into paradoxical “PARA-I” and psychophysiological “PSY-I”) following a mentally challenging battery of cognitive tests. Design: Cross-sectional comparisons of GS, PSY-I, and PARA-I. Setting: Participants slept for 4 consecutive nights in the laboratory where PSG was recorded. Upon awakening on mornings 2 and 3, cognitive testing (lasting 90-120 min) was administered, followed by a 20-minute nap. Participants: Fourteen PSY-I, 12 PARA-I, and 23 GS completed the study, comprising home questionnaires, clinical interviews, night PSG recordings, cognitive testing, and nap PSG recordings. All participants were between 25 and 50 years of age and met inclusion criteria for PSY-I, PARA-I, or GS. Interventions: N/A. Measurements and Results: On objective nap parameters, GS had a longer total sleep time (TST; p = 0.008) and better sleep efficiency (SE; p = 0.009), than PSY-I and PARA-I, and both groups of INS were awake significantly longer than GS (p = 0.003). Also, PARA-I took significantly more time than GS to fall asleep (p = 0.014). Subjectively reported sleepiness was comparable across the three groups. Positive relationships were observed between SE over the night and SE over the nap the following day. Conclusions: Results show that GS sleep better than INS during naps following prolonged cognitive testing, suggesting that, in INS, hyperarousal predominates over mental fatigue resulting from these tests. These results may parallel what is observed at night when INS experience increased cognitive load but are unable to fall asleep. Citation: Pérusse AD; Turcotte I; St-Jean G; Ellis J; Hudon C; Bastien CH. Types of primary insomnia: is hyperarousal also present during napping? J Clin Sleep Med 2013;9(12):1273-1280. PMID:24340289

  1. Napping Reverses Increased Pain Sensitivity Due to Sleep Restriction

    PubMed Central

    Faraut, Brice; Léger, Damien; Medkour, Terkia; Dubois, Alexandre; Bayon, Virginie; Chennaoui, Mounir; Perrot, Serge

    2015-01-01

    Study Objective To investigate pain sensitivity after sleep restriction and the restorative effect of napping. Design A strictly controlled randomized crossover study with continuous polysomnography monitoring was performed. Setting Laboratory-based study. Participants 11 healthy male volunteers. Interventions Volunteers attended two three-day sessions: “sleep restriction” alone and “sleep restriction and nap”. Each session involved a baseline night of normal sleep, a night of sleep deprivation and a night of free recovery sleep. Participants were allowed to sleep only from 02:00 to 04:00 during the sleep deprivation night. During the “sleep restriction and nap” session, volunteers took two 30-minute naps, one in the morning and one in the afternoon. Measurements and Results Quantitative sensory testing was performed with heat, cold and pressure, at 10:00 and 16:00, on three areas: the supraspinatus, lower back and thigh. After sleep restriction, quantitative sensory testing revealed differential changes in pain stimuli thresholds, but not in thermal threshold detection: lower back heat pain threshold decreased, pressure pain threshold increased in the supraspinatus area and no change was observed for the thigh. Napping restored responses to heat pain stimuli in the lower back and to pressure stimuli in the supraspinatus area. Conclusions Sleep restriction induces different types of hypersensitivity to pain stimuli in different body areas, consistent with multilevel mechanisms, these changes being reversed by napping. The napping restorative effect on pain thresholds result principally from effects on pain mechanisms, since it was independent of vigilance status. PMID:25723495

  2. Study of NAP adsorption and assembly on the surface of HOPG.

    PubMed

    Korolkov, Vladimir V; Allen, Stephanie; Roberts, Clive J; Gozes, Illana; Tendler, Saul J B

    2014-12-01

    NAP is an octapeptide that has demonstrated a neuroprotective/therapeutic efficacy at very low concentrations in preclinical studies and in a number of clinical trials. Yet little is known about its structural organization at low concentrations. Here, we have employed atomic force microscopy to investigate NAP peptide assembly on graphite in aqueous media at nanomolar concentration. High spatial resolution scans of NAP assemblies reveal their fine structure with clearly resolved single NAP units. This observation leads us to conclude that NAP molecules do not form complex self-assembled structures at nanomolar concentration when adsorbed on graphite surface.

  3. [The Military Medical Academy's website].

    PubMed

    Kuvakin, V I; Vasil'ev, G G

    2013-12-01

    The article deals with the organization of work, evaluation and optimization of the official web site of the Kirov Military Medical Academy. The website of the Kirov Academy is presented as a multifunctional IT tool for support of its activity. Tasks and functions of the Kirov Academy web site, as well as technological features of its work are listed. Some of its quantitative characteristics as a user tool for the access to information resources of the Kirov Academy are given. The description of the site structure and its pages are presented. The requirements for information materials submitted for posting on the site are set out. The data of webometric ranking of Russian institutions of higher education and research institutes are analyzed, the location of the Academy web site in this rating is shown. The areas for further improvement of the Academy web site, its structure and services are stated. PMID:24738276

  4. Resolution of two native monomeric 90 kDa nitrate reductase active proteins from Shewanella gelidimarina and the sequence of two napA genes

    SciTech Connect

    Simpson, Philippa J.L.; McKinzie, Audra A.; Codd, Rachel

    2010-07-16

    Research highlights: {yields} Two monomeric 90 kDa nitrate reductase active proteins from Shewanella gelidimarina. {yields} Sequence of napA from napEDABC-type operon and napA from NapDAGHB-type operon. {yields} Isolation of NAP as NapA or NapAB correlated with NapA P47E amino acid substitution. -- Abstract: The reduction of nitrate to nitrite in the bacterial periplasm occurs in the 90 kDa NapA subunit of the periplasmic nitrate reductase (NAP) system. Most Shewanella genomes contain two nap operons: napEDABC and napDAGHB, which is an unusual feature of this genus. Two native, monomeric, 90 kDa nitrate reductase active proteins were resolved by hydrophobic interaction chromatography from aerobic cultures of Shewanella gelidimarina replete with reduced nitrogen compounds. The 90 kDa protein obtained in higher yield was characterized as NapA by electronic absorption and electron paramagnetic resonance spectroscopies and was identified by LC/MS/MS and MALDI-TOF/TOF MS as NapA from the napEDABC-type operon. The other 90 kDa protein, which was unstable and produced in low yields, was posited as NapA from the napDAGHB-type operon. Two napA genes have been sequenced from the napEDABC-type and napDAGHB-type operons of S. gelidimarina. Native NAP from S. putrefaciens was resolved as one NapA monomer and one NapAB heterodimer. Two amino acid substitutions in NapA correlated with the isolation of NAP as a NapA monomer or a NapAB heterodimer. The resolution of native, redox-active NapA isoforms in Shewanella provides new insight into the respiratory versatility of this genus, which has implications in bioremediation and the assembly of microbial fuel cells.

  5. Brief naps during post-lunch rest: effects on alertness, performance, and autonomic balance.

    PubMed

    Takahashi, M; Fukuda, H; Arito, H

    1998-07-01

    This study was designed to examine the effects of brief naps taken after lunch on alertness, performance, and autonomic balance. Three groups each comprising ten healthy subjects, who had slept normally at home the previous night, were randomly assigned to groups taking one of three 'lengths of nap (0, 15, and 45 min) after lunch. The P300, an event-related potential which is a neurophysiological correlate of cognitive function, subjective sleepiness (visual analogue scale), and electrocardiogram were measured before, 30 min after, and 3 h after the naps. Each measurement was followed by an English transcription task lasting 90 min. The P300 latency was significantly shorter after the 15-min than after the 45-min nap, or after no nap had been taken, while its amplitude was not affected by the length of nap. Subjective sleepiness was lower after both naps than after no nap. The task performance was significantly better during the second half of the last task session after the 15-min nap than after no nap. The high-frequency component of the R-R interval spectrum increased significantly during the 45-min nap, showing a temporary shift to a predominance of the parasympathetic nervous system. Mean total sleep times during the 15- and 45-min naps were 7.3 and 30.1 min, respectively. These results would indicate that the 15-min nap may serve to shorten the stimulus evaluation time, reducing subjective sleepiness, and slightly improving task performance. Our data demonstrated that in our subjects a brief nap after lunch was effective for enhancing subsequent alertness and performance after normal sleep the previous night.

  6. Maintenance of alertness and performance by a brief nap after lunch under prior sleep deficit.

    PubMed

    Takahashi, M; Arito, H

    2000-09-15

    We examined the effects of a 15-min nap after lunch on subsequent alertness, performance, and autonomic function following a short sleep the preceding night. Subjects were 12 healthy students who had slept for only 4 hours the night before being tested. They experienced both nap and no-nap conditions in a counterbalanced order, at least a week apart. The nap condition included a 15-min nap opportunity (12:30-12:45) in bed with polygraphic monitoring. We measured the P300 event-related potential, subjective sleepiness (Visual Analog Scale), and electrocardiogram (ECG) at 10:00, 13:15, and 16:15, and task performance (logical reasoning and digit span) at 10:00, 11:30, 13:15, 14:45, 16:15, and 17:45. Mean home sleep measured by actigraphy was 3.5 hours under both conditions. At 13:15, the P300 latency after the nap was significantly shorter than after no nap, but its amplitude was not affected by napping. Subjective sleepiness at 13:15 and 14:45 was significantly lower, and accuracy of logical reasoning at 13:15 was significantly higher after the nap than after no nap. No other performance measures or the ECG R-R interval variability parameters differed significantly between the nap and no-nap conditions. Mean total sleep time during the nap was 10.2 min, and no stage 3 and 4 sleep was observed. The above results suggest that under prior sleep deficit, a 15-min nap during post-lunch rest maintains subsequent alertness and performance, particularly in the mid-afternoon.

  7. Intranasal Delivery of Recombinant NT4-NAP/AAV Exerts Potential Antidepressant Effect.

    PubMed

    Ma, Xian-Cang; Chu, Zheng; Zhang, Xiao-Ling; Jiang, Wen-Hui; Jia, Min; Dang, Yong-Hui; Gao, Cheng-Ge

    2016-06-01

    The present study was designed to construct a recombinant adeno-associated virus (rAAV) which can express NAP in the brain and examine whether this virus can produce antidepressant effects on C57 BL/6 mice that had been subjected to open field test and forced swimming test, via nose-to-brain pathway. When the recombinant plasmid pGEM-T Easy/NT4-NAP was digested by EcoRI, 297 bp fragments can be obtained and NT4-NAP sequence was consistent with the designed sequence confirmed by DNA sequencing. When the recombinant plasmid pSSCMV/NT4-NAP was digested by EcoRI, 297 bp fragments is visible. Immunohistochemical staining of fibroblasts revealed that expression of NAP was detected in NT4-NAP/AAV group. Intranasal delivery of NT4-NAP/AAV significantly reduced immobility time when the FST was performed after 1 day from the last administration. The effects observed in the FST could not be attributed to non-specific increases in activity since intranasal delivery of NT4-NAP/AAV did not alter the behavior of the mice during the open field test. The results indicated that a recombinant AAV vector which could express NAP in cells was successfully constructed and NAP may be a potential target for therapeutic action of antidepressant treatment. PMID:26846142

  8. Distance Teaching and Learning Academy.

    ERIC Educational Resources Information Center

    Gosmire, Doreen; Vondruska, Judy

    2001-01-01

    Describes the DTL (Distance Teaching and Learning) Academy that was developed to help South Dakota's teachers use technology more effectively, including two-way videoconferencing equipment. Topics include goals; influence of the TTL (Teaching and Learning Academy); developing distance education courses; professional development opportunities for…

  9. Education at the National Academies

    ERIC Educational Resources Information Center

    Labov, Jay B.

    2003-01-01

    The past three issues of "Cell Biology Education" (CBE) have provided overviews of education projects within the National Research Council's (NRC's) Center for Education, Board on Life Sciences, National Academy of Engineering, and National Academy of Science's Office of Public Understanding of Science. In this article, the author provides…

  10. Strasbourg's "Academy" observatory

    NASA Astrophysics Data System (ADS)

    Heck, André

    2011-08-01

    The observing post located on the roof of Strasbourg's 19th-century "Academy" is generally considered as the second astronomical observatory of the city: a transitional facility between the (unproductive) turret lantern at the top of the Hospital Gate and the German (Wilhelminian) Observatory. The current paper reviews recent findings from archives (blueprints, inventories, correspondence, decrees and other documents) shedding some light on this observatory of which virtually nothing was known to this day. While being, thanks to Chrétien Kramp (1760-1826), an effective attempt to establish an actual observatory equipped with genuine instrumentation, the succession of political regimes in France and the continual bidding for moving the university to other locations, together with the faltering of later scholars, torpedoed any significant scientific usage of the place. A meridian instrument with a Cauchoix objective doublet was however recovered by the German observatory and is still existing.

  11. User's reference guide for Noise Assessment Prediction System (NAPS)

    NASA Astrophysics Data System (ADS)

    Smith, Joyce A.; Luers, James K.; Dietenberger, Mark A.

    1992-07-01

    The noise assessment and prediction system (NAPS) model provides an estimate of the surface peak noise intensity in all directions surrounding a blast source. The model makes use of a personal computer. An essential feature of the model is its ability to account for meteorological and topographical variations in the calculation of blast sound propagation. In performing noise intensity estimates, acoustic ray traces are generated over a sufficient range of azimuth and elevation angles to define the focusing and shadow regions in the area surrounding the airblast. The acoustics of the model include the effects of spherical acoustic spreading, absorption, focusing, shadow zones, reflection of rays from water, interference of multiple rays arriving at the same location, and the directional asymmetry of a blastwave. The NAPS model has been implemented at Aberdeen Proving Ground, Maryland, using acoustic sounder, upper air, and surface station data to provide on-line meteorological input. Plots of ray trace trajectories and sound intensity contour levels on a background map of the Aberdeen area, along with tabular data, are included as model features. This user's reference guide describes the procedures for running the NAPS model. It also includes examples of the required input data files and examples of the graphic outputs generated by the model.

  12. American Academy of Home Care Medicine

    MedlinePlus

    ... Newsletter Certification/Training Donate Featured Members Home Care Medicine in America The American Academy of Home Care ... Resources with the American Academy of Home Care Medicine. The American Academy of Home Care Medicine understands ...

  13. The efficacy of naps as a fatigue countermeasure: a meta-analytic integration.

    PubMed

    Driskell, James E; Mullen, Brian

    2005-01-01

    Modern requirements for extended operations in aviation, transportation, the military, and industry have led to extensive research on countermeasures to mitigate the adverse effects of fatigue. The goals of this research were to (a) summarize and integrate existing research on naps as a fatigue countermeasure using meta-analysis, (b) identify the strength and significance of the effects of naps on performance and feelings of fatigue, and (c) identify factors that may moderate the effects of napping as a fatigue countermeasure. The results of these analyses can be used to predict nap efficacy as a function of length of the nap and the postnap interval. The results of these analyses also suggest an approach to work design that takes into account the optimal effects of naps as a fatigue countermeasure. Actual or potential applications of this research include the development of optimal work schedules to minimize fatigue and increase safety.

  14. The histone chaperones Vps75 and Nap1 form ring-like, tetrameric structures in solution.

    PubMed

    Bowman, Andrew; Hammond, Colin M; Stirling, Andrew; Ward, Richard; Shang, Weifeng; El-Mkami, Hassane; Robinson, David A; Svergun, Dmitri I; Norman, David G; Owen-Hughes, Tom

    2014-05-01

    NAP-1 fold histone chaperones play an important role in escorting histones to and from sites of nucleosome assembly and disassembly. The two NAP-1 fold histone chaperones in budding yeast, Vps75 and Nap1, have previously been crystalized in a characteristic homodimeric conformation. In this study, a combination of small angle X-ray scattering, multi angle light scattering and pulsed electron-electron double resonance approaches were used to show that both Vps75 and Nap1 adopt ring-shaped tetrameric conformations in solution. This suggests that the formation of homotetramers is a common feature of NAP-1 fold histone chaperones. The tetramerisation of NAP-1 fold histone chaperones may act to shield acidic surfaces in the absence of histone cargo thus providing a 'self-chaperoning' type mechanism. PMID:24688059

  15. The histone chaperones Vps75 and Nap1 form ring-like, tetrameric structures in solution

    PubMed Central

    Bowman, Andrew; Hammond, Colin M.; Stirling, Andrew; Ward, Richard; Shang, Weifeng; El-Mkami, Hassane; Robinson, David A.; Svergun, Dmitri I.; Norman, David G.; Owen-Hughes, Tom

    2014-01-01

    NAP-1 fold histone chaperones play an important role in escorting histones to and from sites of nucleosome assembly and disassembly. The two NAP-1 fold histone chaperones in budding yeast, Vps75 and Nap1, have previously been crystalized in a characteristic homodimeric conformation. In this study, a combination of small angle X-ray scattering, multi angle light scattering and pulsed electron–electron double resonance approaches were used to show that both Vps75 and Nap1 adopt ring-shaped tetrameric conformations in solution. This suggests that the formation of homotetramers is a common feature of NAP-1 fold histone chaperones. The tetramerisation of NAP-1 fold histone chaperones may act to shield acidic surfaces in the absence of histone cargo thus providing a ‘self-chaperoning’ type mechanism. PMID:24688059

  16. Does Increased Consolidated Nighttime Sleep Facilitate Attentional Control? A Pilot Study of Nap Restriction in Preschoolers

    PubMed Central

    Lam, Janet C.; Koriakin, Taylor A.; Scharf, Steven M.; Mason, Thornton B. A.; Mahone, E. Mark

    2016-01-01

    Objective The aim of this study is to understand the impact of a 5-day period of nap restriction on sleep patterns and cognitive function in typically developing preschoolers, aged 3 to 4 years. Method Following 1 week of baseline assessment, 28 children were randomly assigned to either a “napping as usual” group (n = 15) or a 5-day period of nap restriction (n = 13). Sleep was assessed with sleep logs and actigraphy; cognition was assessed at baseline and at the end of the intervention week. Results No group differences in sleep or cognitive function were observed at baseline. For the no-nap group, the 5-day period of daytime nap restriction resulted in increased nighttime sleep. Children in the no-nap group also showed a significant improvement in attentional control compared with baseline, whereas no such changes were observed among children in the napping-as-usual group. Conclusion In preschool children who typically take naps, short-term nap restriction is associated with increased nighttime sleep and may contribute to improved attentional function. PMID:25646024

  17. Reciprocating pellet press

    DOEpatents

    Jones, Charles W.

    1981-04-07

    A machine for pressing loose powder into pellets using a series of reciprocating motions has an interchangeable punch and die as its only accurately machines parts. The machine reciprocates horizontally between powder receiving and pressing positions. It reciprocates vertically to press, strip and release a pellet.

  18. The Global University Press

    ERIC Educational Resources Information Center

    Dougherty, Peter J.

    2012-01-01

    The modern world's understanding of American university press has long been shaped by university-press books. American university-press books are good international advertisements for the universities whose logos grace their spines. The growth of transnational scholarship and the expansion of digital communications networks are converging in ways…

  19. Utah Principals Academy, 1987-1988.

    ERIC Educational Resources Information Center

    Utah State Board of Education, Salt Lake City.

    Improving instructional leadership skills of principals is the focus of the academy. Following a foreword and mission statement by James R. Moss, the state superintendent of public instruction, the booklet describes three programs that help to achieve the academy's goals: Academy Fellows, Academy Seminars, and Cluster Grants. Titles and authors of…

  20. 46 CFR 310.67 - Academy regulations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false Academy regulations. 310.67 Section 310.67 Shipping... Training of Midshipmen at the United States Merchant Marine Academy § 310.67 Academy regulations. The Superintendent of the Academy is delegated authority to issue all regulations necessary for the accomplishment...

  1. 46 CFR 310.67 - Academy regulations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 8 2014-10-01 2014-10-01 false Academy regulations. 310.67 Section 310.67 Shipping... Training of Midshipmen at the United States Merchant Marine Academy § 310.67 Academy regulations. The Superintendent of the Academy is delegated authority to issue all regulations necessary for the accomplishment...

  2. 46 CFR 310.67 - Academy regulations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 8 2013-10-01 2013-10-01 false Academy regulations. 310.67 Section 310.67 Shipping... Training of Midshipmen at the United States Merchant Marine Academy § 310.67 Academy regulations. The Superintendent of the Academy is delegated authority to issue all regulations necessary for the accomplishment...

  3. 46 CFR 310.67 - Academy regulations.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 8 2012-10-01 2012-10-01 false Academy regulations. 310.67 Section 310.67 Shipping... Training of Midshipmen at the United States Merchant Marine Academy § 310.67 Academy regulations. The Superintendent of the Academy is delegated authority to issue all regulations necessary for the accomplishment...

  4. The Peninsula Academies. Third Yearly Interim Report.

    ERIC Educational Resources Information Center

    Reynolds, Dorothy F.

    The performance of the Peninsula Academies of Electronics and Computer Technology was assessed for the program's third year of operation in two host schools in the Sequoia Union High School District. Data were collected for approximately 190 Academy students and for a comparison group of non-Academy students. Academies students missed fewer days…

  5. Periplasmic Nitrate Reductase (NapABC Enzyme) Supports Anaerobic Respiration by Escherichia coli K-12

    PubMed Central

    Stewart, Valley; Lu, Yiran; Darwin, Andrew J.

    2002-01-01

    Periplasmic nitrate reductase (NapABC enzyme) has been characterized from a variety of proteobacteria, especially Paracoccus pantotrophus. Whole-genome sequencing of Escherichia coli revealed the structural genes napFDAGHBC, which encode NapABC enzyme and associated electron transfer components. E. coli also expresses two membrane-bound proton-translocating nitrate reductases, encoded by the narGHJI and narZYWV operons. We measured reduced viologen-dependent nitrate reductase activity in a series of strains with combinations of nar and nap null alleles. The napF operon-encoded nitrate reductase activity was not sensitive to azide, as shown previously for the P. pantotrophus NapA enzyme. A strain carrying null alleles of narG and narZ grew exponentially on glycerol with nitrate as the respiratory oxidant (anaerobic respiration), whereas a strain also carrying a null allele of napA did not. By contrast, the presence of napA+ had no influence on the more rapid growth of narG+ strains. These results indicate that periplasmic nitrate reductase, like fumarate reductase, can function in anaerobic respiration but does not constitute a site for generating proton motive force. The time course of Φ(napF-lacZ) expression during growth in batch culture displayed a complex pattern in response to the dynamic nitrate/nitrite ratio. Our results are consistent with the observation that Φ(napF-lacZ) is expressed preferentially at relatively low nitrate concentrations in continuous cultures (H. Wang, C.-P. Tseng, and R. P. Gunsalus, J. Bacteriol. 181:5303-5308, 1999). This finding and other considerations support the hypothesis that NapABC enzyme may function in E. coli when low nitrate concentrations limit the bioenergetic efficiency of nitrate respiration via NarGHI enzyme. PMID:11844760

  6. Education at the National Academies: Three Recent Reports on Improving Science Education

    ERIC Educational Resources Information Center

    Labov, Jay B.

    2006-01-01

    In this article, the author describes three reports conducted by the National Academies, a private, nonprofit organization whose charter is to assist the federal government and the American people in analyzing pressing science and technology policy issues. These reports are: (1) "Rising Above the Gathering Storm: Energizing and Employing America…

  7. Histone chaperones Nap1 and Vps75 regulate histone acetylation during transcription elongation.

    PubMed

    Xue, Yu-Ming; Kowalska, Anna K; Grabowska, Kamila; Przybyt, Katarzyna; Cichewicz, Magda A; Del Rosario, Brian C; Pemberton, Lucy F

    2013-04-01

    Histone chaperones function in chromatin assembly and disassembly, suggesting they have important regulatory roles in transcription elongation. The Saccharomyces cerevisiae proteins Nap1 and Vps75 are structurally related, evolutionarily conserved histone chaperones. We showed that Nap1 genetically interacts with several transcription elongation factors and that both Nap1 and Vps75 interact with the RNA polymerase II kinase, CTK1. Loss of NAP1 or VPS75 suppressed cryptic transcription within the open reading frame (ORF) observed when strains are deleted for the kinase CTK1. Loss of the histone acetyltransferase Rtt109 also suppressed ctk1-dependent cryptic transcription. Vps75 regulates Rtt109 function, suggesting that they function together in this process. Histone H3 K9 was found to be the important lysine that is acetylated by Rtt109 during ctk1-dependent cryptic transcription. We showed that both Vps75 and Nap1 regulate the relative level of H3 K9 acetylation in the STE11 ORF. This supports a model in which Nap1, like Vps75, directly regulates Rtt109 activity or regulates the assembly of acetylated chromatin. Although Nap1 and Vps75 share many similarities, due to their distinct interactions with SET2, Nap1 and Vps75 may also play separate roles during transcription elongation. This work sheds further light on the importance of histone chaperones as general regulators of transcription elongation. PMID:23401858

  8. Multisite phosphorylation of C-Nap1 releases it from Cep135 to trigger centrosome disjunction.

    PubMed

    Hardy, Tara; Lee, Miseon; Hames, Rebecca S; Prosser, Suzanna L; Cheary, Donna-Marie; Samant, Mugdha D; Schultz, Francisca; Baxter, Joanne E; Rhee, Kunsoo; Fry, Andrew M

    2014-06-01

    During mitotic entry, centrosomes separate to establish the bipolar spindle. Delays in centrosome separation can perturb chromosome segregation and promote genetic instability. However, interphase centrosomes are physically tethered by a proteinaceous linker composed of C-Nap1 (also known as CEP250) and the filamentous protein rootletin. Linker disassembly occurs at the onset of mitosis in a process known as centrosome disjunction and is triggered by the Nek2-dependent phosphorylation of C-Nap1. However, the mechanistic consequences of C-Nap1 phosphorylation are unknown. Here, we demonstrate that Nek2 phosphorylates multiple residues within the C-terminal domain of C-Nap1 and, collectively, these phosphorylation events lead to loss of oligomerization and centrosome association. Mutations in non-phosphorylatable residues that make the domain more acidic are sufficient to release C-Nap1 from the centrosome, suggesting that it is an increase in overall negative charge that is required for this process. Importantly, phosphorylation of C-Nap1 also perturbs interaction with the core centriolar protein, Cep135, and interaction of endogenous C-Nap1 and Cep135 proteins is specifically lost in mitosis. We therefore propose that multisite phosphorylation of C-Nap1 by Nek2 perturbs both oligomerization and Cep135 interaction, and this precipitates centrosome disjunction at the onset of mitosis. PMID:24695856

  9. Comparing the benefits of Caffeine, Naps and Placebo on Verbal, Motor and Perceptual Memory

    PubMed Central

    Mednick, Sara C.; Cai, Denise J.; Kanady, Jennifer; Drummond, Sean P.A.

    2008-01-01

    Caffeine, the world’s most common psychoactive substance, is used by approximately 90% of North Americans everyday. Little is known, however, about its benefits for memory. Napping has been shown to increase alertness and promote learning on some memory tasks. We directly compared caffeine (200mg) with napping (60–90 minutes) and placebo on three distinct memory processes: declarative verbal memory, procedural motor skills, and perceptual learning. In the verbal task, recall and recognition for unassociated words were tested after a 7hr retention period (with a between-session nap or drug intervention). A second, different, word list was administered post-intervention and memory was tested after a 20min retention period. The non-declarative tasks (finger tapping task and texture discrimination task) were trained before the intervention and then retested afterwards. Naps enhanced recall of words after a 7hr and 20min retention interval relative to both caffeine and placebo. Caffeine significantly impaired motor learning compared to placebo and naps. Napping produced robust perceptual learning compared with placebo; however, naps and caffeine were not significantly different. These findings provide evidence of the limited benefits of caffeine for memory improvement compared with napping. We hypothesize that impairment from caffeine may be restricted to tasks that contain explicit information; whereas strictly implicit learning is less compromised. PMID:18554731

  10. Naps in school can enhance the duration of declarative memories learned by adolescents

    PubMed Central

    Lemos, Nathalia; Weissheimer, Janaina; Ribeiro, Sidarta

    2014-01-01

    Sleep helps the consolidation of declarative memories in the laboratory, but the pro-mnemonic effect of daytime naps in schools is yet to be fully characterized. While a few studies indicate that sleep can indeed benefit school learning, it remains unclear how best to use it. Here we set out to evaluate the influence of daytime naps on the duration of declarative memories learned in school by students of 10–15 years old. A total of 584 students from 6th grade were investigated. Students within a regular classroom were exposed to a 15-min lecture on new declarative contents, absent from the standard curriculum for this age group. The students were then randomly sorted into nap and non-nap groups. Students in the nap group were conducted to a quiet room with mats, received sleep masks and were invited to sleep. At the same time, students in the non-nap group attended regular school classes given by their usual teacher (Experiment I), or English classes given by another experimenter (Experiment II). These 2 versions of the study differed in a number of ways. In Experiment I (n = 371), students were pre-tested on lecture-related contents before the lecture, were invited to nap for up to 2 h, and after 1, 2, or 5 days received surprise tests with similar content but different wording and question order. In Experiment II (n = 213), students were invited to nap for up to 50 min (duration of a regular class); surprise tests were applied immediately after the lecture, and repeated after 5, 30, or 110 days. Experiment I showed a significant ~10% gain in test scores for both nap and non-nap groups 1 day after learning, in comparison with pre-test scores. This gain was sustained in the nap group after 2 and 5 days, but in the non-nap group it decayed completely after 5 days. In Experiment II, the nap group showed significantly higher scores than the non-nap group at all times tested, thus precluding specific conclusions. The results suggest that sleep can be used to enhance

  11. Naps in school can enhance the duration of declarative memories learned by adolescents.

    PubMed

    Lemos, Nathalia; Weissheimer, Janaina; Ribeiro, Sidarta

    2014-01-01

    Sleep helps the consolidation of declarative memories in the laboratory, but the pro-mnemonic effect of daytime naps in schools is yet to be fully characterized. While a few studies indicate that sleep can indeed benefit school learning, it remains unclear how best to use it. Here we set out to evaluate the influence of daytime naps on the duration of declarative memories learned in school by students of 10-15 years old. A total of 584 students from 6th grade were investigated. Students within a regular classroom were exposed to a 15-min lecture on new declarative contents, absent from the standard curriculum for this age group. The students were then randomly sorted into nap and non-nap groups. Students in the nap group were conducted to a quiet room with mats, received sleep masks and were invited to sleep. At the same time, students in the non-nap group attended regular school classes given by their usual teacher (Experiment I), or English classes given by another experimenter (Experiment II). These 2 versions of the study differed in a number of ways. In Experiment I (n = 371), students were pre-tested on lecture-related contents before the lecture, were invited to nap for up to 2 h, and after 1, 2, or 5 days received surprise tests with similar content but different wording and question order. In Experiment II (n = 213), students were invited to nap for up to 50 min (duration of a regular class); surprise tests were applied immediately after the lecture, and repeated after 5, 30, or 110 days. Experiment I showed a significant ~10% gain in test scores for both nap and non-nap groups 1 day after learning, in comparison with pre-test scores. This gain was sustained in the nap group after 2 and 5 days, but in the non-nap group it decayed completely after 5 days. In Experiment II, the nap group showed significantly higher scores than the non-nap group at all times tested, thus precluding specific conclusions. The results suggest that sleep can be used to enhance

  12. Effects of afternoon "siesta" naps on sleep, alertness, performance, and circadian rhythms in the elderly

    NASA Technical Reports Server (NTRS)

    Monk, T. H.; Buysse, D. J.; Carrier, J.; Billy, B. D.; Rose, L. R.

    2001-01-01

    STUDY OBJECTIVES: To determine the effects of a 90-minute afternoon nap regimen on nocturnal sleep, circadian rhythms, and evening alertness and performance levels in the healthy elderly. DESIGN AND SETTING: Nine healthy elderly subjects (4m, 5f, age range 74y-87y) each experienced both nap and no-nap conditions in two studies each lasting 17 days (14 at home, 3 in the laboratory). In the nap condition a 90-minute nap was enforced between 13:30 and 15:00 every day, in the no-nap condition daytime napping was prohibited, and activity encouraged in the 13:30-15:00 interval. The order of the two conditions was counterbalanced. PARTICIPANTS: N/A INTERVENTIONS: N/A MEASUREMENTS: Diary measures, pencil and paper alertness tests, and wrist actigraphy were used at home. In the 72 hour laboratory studies, these measures were augmented by polysomnographic sleep recording, continuous rectal temperature measurement, a daily evening single trial of a Multiple Sleep Latency Test (MSLT), and computerized tests of mood, activation and performance efficiency. RESULTS: By the second week in the "at home" study, an average of 58 minutes of sleep was reported per siesta nap; in the laboratory, polysomnography confirmed an average of 57 minutes of sleep per nap. When nap and no-nap conditions were compared, mixed effects on nocturnal sleep were observed. Diary measures indicated no significant difference in nocturnal sleep duration, but a significant increase (of 38 mins.) in 24-hour Total Sleep Time (TST) when nocturnal sleeps and naps were added together (p<0.025). The laboratory study revealed a decrease of 2.4% in nocturnal sleep efficiency in the nap condition (p<0.025), a reduction of nocturnal Total Sleep Time (TST) by 48 mins. in the nap condition (p<0.001) which resulted primarily from significantly earlier waketimes (p<0.005), but no reliable effects on Wake After Sleep Onset (WASO), delta sleep measures, or percent stages 1 & 2. Unlike the diary study, the laboratory study

  13. Stable complex formation between HIV Rev and the nucleosome assembly protein, NAP1, affects Rev function

    SciTech Connect

    Cochrane, Alan; Murley, Laura Lea; Gao Mian; Wong, Raymond; Clayton, Kiera; Brufatto, Nicole; Canadien, Veronica; Mamelak, Daniel; Chen, Tricia; Richards, Dawn; Zeghouf, Mahel; Greenblatt, Jack; Burks, Christian; Frappier, Lori

    2009-05-25

    The Rev protein of HIV-1 is essential for HIV-1 proliferation due to its role in exporting viral RNA from the nucleus. We used a modified version of tandem affinity purification (TAP) tagging to identify proteins interacting with HIV-1 Rev in human cells and discovered a prominent interaction between Rev and nucleosome assembly protein 1 (Nap1). This interaction was also observed by specific retention of Nap1 from human cell lysates on a Rev affinity column. Nap1 was found to bind Rev through the Rev arginine-rich domain and altered the oligomerization state of Rev in vitro. Overexpression of Nap1 stimulated the ability of Rev to export RNA, reduced the nucleolar localization of Rev, and affected Rev nuclear import rates. The results suggest that Nap-1 may influence Rev function by increasing the availability of Rev.

  14. 1997 NASA Academy in Aeronautics

    NASA Technical Reports Server (NTRS)

    Andrisani, Dominick, II

    1998-01-01

    The NASA Academy in Aeronautics at the Dryden Flight Research Center (DFRC) was a ten-week summer leadership training program conducted for the first time in the summer of 1997. Funding was provided by a contract between DFRC and Purdue University. Mr. Lee Duke of DFRC was the contract monitor, and Professor Dominick Andrisani was the principal investigator. Five student research associates participated in the program. Biographies of the research associates are given in Appendix 1. Dominick Andrisani served as Dean of the NASA Academy in Aeronautics. NASA Academy in Aeronautics is a unique summer institute of higher learning that endeavors to provide insight into all of the elements that make NASA aeronautical research possible. At the same time the Academy assigns the research associate to be mentored by one of NASA!s best researchers so that they can contribute towards an active flight research program. Aeronautical research and development are an investment in the future, and NASA Academy is an investment in aeronautical leaders of the future. The Academy was run by the Indiana Space Grant Consortium at Purdue in strategic partnership with the National Space Grant College and Fellowship Program. Research associates at the Academy were selected with help from the Space Grant Consortium that sponsored the research associate. Research associate stipend and travel to DFRC were paid by the students' Space Grant Consortium. All other student expenses were paid by the Academy. Since the Academy at DFRC had only five students the opportunity for individual growth and attention was unique in the country. About 30% of the working time and most of the social time of the students were be spent as a "group" or "team." This time was devoted to exchange of ideas, on forays into the highest levels of decision making, and in executing aeronautical research. This was done by interviewing leaders throughout the aerospace industry, seminars, working dinners, and informal

  15. University Presses: Problems and Prospects.

    ERIC Educational Resources Information Center

    Meeker, Robert B.

    Historical information on university presses and their problems are considered. University presses in the United States have their roots in 15th century England when the Oxford University Press was established in 1478. The first U.S. press to use the term "university press" was Cornell University; the press operated from 1869 until it was closed…

  16. Racial Differences in Reported Napping and Nocturnal Sleep in 2- to 8-Year-Old Children

    PubMed Central

    Crosby, Brian; LeBourgeois, Monique K.; Harsh, John

    2010-01-01

    Objectives The objectives of this study were to examine racial differences in reported napping and nighttime sleep of 2- to 8-year-old children, to identify factors accounting for these differences, and to determine if variability in napping was related to psychosocial functioning. Methods Caretakers of 1043 children (73.5% non-Hispanic white; 50.4% male) 2 to 8 years old from a community sample reported on their children’s napping behavior and nighttime sleep. Caretakers of 255 preschool children (3–5 years old) also completed the Behavior Assessment System for Children. Results A more gradual age-related decline in napping was found for black children. At age 8, 39.1% of black children were reported to nap, compared with only 4.9% of white children. Black children also napped significantly more days per week, had shorter average nocturnal sleep durations, and slept significantly less on weekdays than on weekend nights. Despite differences in sleep distribution, total weekly sleep duration (diurnal and nocturnal) was nearly identical for the 2 racial groups at each year of age. Logistic regression analysis revealed that demographic variables were related to but did not fully explain napping differences. Napping in a subset of preschoolers was not significantly related to psychosocial functioning. Conclusions There are remarkable racial differences in reported napping and nighttime sleep patterns beginning as early as age 3 and extending to at least 8 years of age. These differences are independent of commonly investigated demographic factors. Differences in napping behavior do not seem to have psychosocial significance in a sample of preschool children. PMID:15866856

  17. SCN controlled circadian arousal and the afternoon "nap zone".

    PubMed

    Broughton, R J

    1998-01-01

    This paper outlines a conceptual model for the regulation of the circasemidian sleep propensity process with emphasis on a possible mechanism of the afternoon "nap zone". It is proposed that the afternoon nap zone is due to increasing sleep propensity after morning wakening (Borb ly's Process-S) being overwhelmed by a light-sensitive SCN-dependent circadian arousal process of the type discovered by Edgar et al., (1993) and currently being identified in its pathways and neurochemistry by Jouvet and colleagues. It is maintained that this arousal process is reflected in the circadian core body temperature pattern, and that under normal entrained conditions the latter does not resemble a sine-wave or skewed sine-wave. Rather it is very asymmetrical in time and somewhat asymmetrical in amplitude. Cosinor type analyses which enforce symmetry in time and amplitude are therefore ill suited to adequately curve-fit the empirical data. The shape of the circadian arousal system was clarified by meta-analyses of data from three laboratories for three conditions: the normal entrained state, the constant routine, and temporal isolation. Under normal entrained conditions for about one-third of the circadian day core body temperature, and therefore the assumed intensity of the circadian arousal system, is below the mesor with the nadir being at about 0500h; and for about two-thirds of the circadian day it is above the mesor with the acrophase on average being at about 2100h. For modeling purposes, the homeostatic process (Process-S) employed the actual data of the Zurich laboratories for night sleep, but altered the equation for the daytime period to ensure an exponential increase after wake-up. Combining these modified processes indicated that the nap zone could be explained, as predicted, by an increasing homeostatic pressure for sleep across the daytime being reversed by the circadian arousal process. This 2-process combination predicted quite well the shape of the entire

  18. Duration of sleep inertia after napping during simulated night work and in extended operations.

    PubMed

    Signal, Tracey Leigh; van den Berg, Margo J; Mulrine, Hannah M; Gander, Philippa H

    2012-07-01

    Due to the mixed findings of previous studies, it is still difficult to provide guidance on how to best manage sleep inertia after waking from naps in operational settings. One of the few factors that can be manipulated is the duration of the nap opportunity. The aim of the present study was to investigate the magnitude and time course of sleep inertia after waking from short (20-, 40- or 60-min) naps during simulated night work and extended operations. In addition, the effect of sleep stage on awakening and duration of slow wave sleep (SWS) on sleep inertia was assessed. Two within-subject protocols were conducted in a controlled laboratory setting. Twenty-four healthy young men (Protocol 1: n = 12, mean age = 25.1 yrs; Protocol 2: n = 12, mean age = 23.2 yrs) were provided with nap opportunities of 20-, 40-, and 60-min (and a control condition of no nap) ending at 02:00 h after ∼20 h of wakefulness (Protocol 1 [P1]: simulated night work) or ending at 12:00 h after ∼30 h of wakefulness (Protocol 2 [P2]: simulated extended operations). A 6-min test battery, including the Karolinska Sleepiness Scale (KSS) and the 4-min 2-Back Working Memory Task (WMT), was repeated every 15 min the first hour after waking. Nap sleep was recorded polysomnographically, and in all nap opportunities sleep onset latency was short and sleep efficiency high. Mixed-model analyses of variance (ANOVA) for repeated measures were calculated and included the factors time (time post-nap), nap opportunity (duration of nap provided), order (order in which the four protocols were completed), and the interaction of these terms. Results showed no test x nap opportunity effect (i.e., no effect of sleep inertia) on KSS. However, WMT performance was impaired (slower reaction time, fewer correct responses, and increased omissions) on the first test post-nap, primarily after a 40- or 60-min nap. In P2 only, performance improvement was evident 45 min post-awakening for naps of 40 min or more. In ANOVAs

  19. Coordinated Action of Nap1 and RSC in Disassembly of Tandem Nucleosomes.

    PubMed

    Prasad, Rashmi; D'Arcy, Sheena; Hada, Arjan; Luger, Karolin; Bartholomew, Blaine

    2016-09-01

    The SWI/SNF and RSC family of ATP-dependent chromatin remodelers disassembles nucleosomes by moving nucleosomes into the vicinity of adjoining nucleosomes. We found that the histone chaperone Nap1 efficiently promotes disassembly of adjacent nucleosomes with which RSC collides and not the disassembly of nucleosomes mobilized by RSC. Nap1 is specific to RSC, as it does not target SWI/SNF, its paralog in Saccharomyces cerevisiae Extensive mutational analysis of Nap1 has revealed that Nap1 affinity for histones H2A-H2B and H3-H4 and its ability to displace histones from DNA are required for Nap1 to enhance RSC-mediated disassembly. Other histone chaperones, such as Vps75, that also bind histones are not able to enhance RSC-mediated disassembly. Our study suggests a mechanism by which Nap1 is recruited to actively transcribed regions and assists in the passage of the transcription complex through chromatin, and it provides a novel mechanism for the coordinated action of RSC and Nap1.

  20. Coordinated Action of Nap1 and RSC in Disassembly of Tandem Nucleosomes.

    PubMed

    Prasad, Rashmi; D'Arcy, Sheena; Hada, Arjan; Luger, Karolin; Bartholomew, Blaine

    2016-09-01

    The SWI/SNF and RSC family of ATP-dependent chromatin remodelers disassembles nucleosomes by moving nucleosomes into the vicinity of adjoining nucleosomes. We found that the histone chaperone Nap1 efficiently promotes disassembly of adjacent nucleosomes with which RSC collides and not the disassembly of nucleosomes mobilized by RSC. Nap1 is specific to RSC, as it does not target SWI/SNF, its paralog in Saccharomyces cerevisiae Extensive mutational analysis of Nap1 has revealed that Nap1 affinity for histones H2A-H2B and H3-H4 and its ability to displace histones from DNA are required for Nap1 to enhance RSC-mediated disassembly. Other histone chaperones, such as Vps75, that also bind histones are not able to enhance RSC-mediated disassembly. Our study suggests a mechanism by which Nap1 is recruited to actively transcribed regions and assists in the passage of the transcription complex through chromatin, and it provides a novel mechanism for the coordinated action of RSC and Nap1. PMID:27273866

  1. Knowledge Management and the Academy

    ERIC Educational Resources Information Center

    Cain, Timothy J.; Branin, Joseph J.; Sherman, W. Michael

    2008-01-01

    Universities and colleges generate extraordinary quantities of knowledge and innovation, but in many ways the academy struggles to keep pace with the digital revolution. Growing pressures are reshaping how universities must do business--students expecting enhanced access and support, administrators eager to make data-driven strategic decisions,…

  2. Carnegie Science Academy Web Site

    NASA Astrophysics Data System (ADS)

    Kotwicki, John; Atzinger, Joe; Turso, Denise

    1997-11-01

    The Carnegie Science Academy is a professional society "For Teens...By Teens" at the Carnegie Science Center in Pittsburgh. The CSA Web Site [ http://csa.clpgh.org ] is designed for teens who have an interest in science and technology. This online or virtual science academy provides resources for teens in high school science classes. The Web site also allows students around the world to participate and communicate with other students, discuss current events in science, share opinions, find answers to questions, or make online friends. Visitors can enjoy the main components of the site or sign up for a free membership which allows access to our chat room for monthly meeting, online newsletter, members forum, and much more. Main components to the site include a spot for cool links and downloads, available for any visitor to download or view. Online exhibits are created by students to examine and publish an area of study and also allow teachers to easily post classroom activities as exhibits by submitting pictures and text. Random Access, the interactive part of the academy, allows users to share ideas and opinions. Planet CSA focuses on current events in science and the academy. In the future the CSA Web site will become a major resource for teens and science teachers providing materials that will allow students to further enhance their interest and experiences in science.

  3. INSPIRED High School Computing Academies

    ERIC Educational Resources Information Center

    Doerschuk, Peggy; Liu, Jiangjiang; Mann, Judith

    2011-01-01

    If we are to attract more women and minorities to computing we must engage students at an early age. As part of its mission to increase participation of women and underrepresented minorities in computing, the Increasing Student Participation in Research Development Program (INSPIRED) conducts computing academies for high school students. The…

  4. Caliber Schools. Caliber: Beta Academy

    ERIC Educational Resources Information Center

    EDUCAUSE, 2015

    2015-01-01

    Caliber: Beta Academy is reimagining education as we know it, with the belief that the innovations in its model will allow 100% of its students to graduate ready to attend and succeed in a competitive four-year college and beyond. The academic model of the school features personalized learning plans, blended learning for English and math,…

  5. High School Press Freedom.

    ERIC Educational Resources Information Center

    Maurer, Diana J.

    This report focuses on controversial articles written by the high school press, decisions made by the courts regarding students' press freedoms, and reactions to the articles and rulings. Particular attention is given to two rulings concerning censorship of articles about students' sexual atttiudes and activities, the issue of prior restraint of…

  6. High School Press Pressures.

    ERIC Educational Resources Information Center

    Rogers, Luella P.

    History shows that the high school press suffers through cycles that reflect economic factors and cultural climates within communities, states, and the nation. The direction of that cycle in the 1960s and early 1970s was toward more open, free-flowing information by a vigorous student press, but those economic and cultural signs now are pointing…

  7. Lyndon Johnson's Press Conferences.

    ERIC Educational Resources Information Center

    Cooper, Stephen

    Because President Lyndon Johnson understood well the publicity value of the American news media, he sought to exploit them. He saw reporters as "torch bearers" for his programs and policies and used the presidential press conference chiefly for promotional purposes. Although he met with reporters often, his press conferences were usually…

  8. The Segregation Academy and the Law

    ERIC Educational Resources Information Center

    Champagne, Anthony M.

    1973-01-01

    A case study of one private school which functions as a segregation academy'' was done in order to learn more about what segregation academies are, how they operate, and how they relate to the community. (Author/JM)

  9. Reality and dreams: state of the academy.

    PubMed

    Torabi, Mohammad R

    2005-01-01

    These remarks were presented at the opening ceremony of the American Academy of Health Behavior (AAHB) annual scientific conference held in Charleston, SC, in February 2005 by the outgoing president of the Academy. PMID:16336101

  10. Building Career Tech Programs into Career Academies

    ERIC Educational Resources Information Center

    Delano, Rick; Mittelsteadt, Sandy

    2005-01-01

    In Manatee County, Florida, not only did they build career tech programs into career academies, but they also developed an evaluation process to ensure these career academies were credible. A District Academic team created the "Documentation of Academy Assessment Criteria" with 12 core components and a rubric that helps evaluators determine the…

  11. Authentic Assessment in the First Steiner Academy

    ERIC Educational Resources Information Center

    Burnett, John

    2009-01-01

    In August 2008, the then Schools Minister, Andrew Adonis, gave the go-ahead for the privately funded Hereford Waldorf School to reopen as a tax-payer-funded Academy, sponsored by the Steiner Waldorf Schools Fellowship of Great Britain. Accordingly, the Steiner Academy Hereford opened in September 2008. In common with the 132 other Academies opened…

  12. New Petrochemical Science and Technology Academy

    ERIC Educational Resources Information Center

    Majka, Connie

    2005-01-01

    In 1969, the first academy opened at Thomas Edison High School in Philadelphia. Called the Academy of Applied Electrical Science, the program was set up as an independent not-for-profit corporation with its own board of directors. Over the years, three more career areas--business, health and automotive--opened academies as independent entities. …

  13. Regulation of nap Gene Expression and Periplasmic Nitrate Reductase Activity in the Phototrophic Bacterium Rhodobacter sphaeroides DSM158

    PubMed Central

    Gavira, Mónica; Roldán, M. Dolores; Castillo, Francisco; Moreno-Vivián, Conrado

    2002-01-01

    Bacterial periplasmic nitrate reductases (Nap) can play different physiological roles and are expressed under different conditions depending on the organism. Rhodobacter sphaeroides DSM158 has a Nap system, encoded by the napKEFDABC gene cluster, but nitrite formed is not further reduced because this strain lacks nitrite reductase. Nap activity increases in the presence of nitrate and oxygen but is unaffected by ammonium. Reverse transcription-PCR and Northern blots demonstrated that the napKEFDABC genes constitute an operon transcribed as a single 5.5-kb product. Northern blots and nap-lacZ fusions revealed that nap expression is threefold higher under aerobic conditions but is regulated by neither nitrate nor ammonium, although it is weakly induced by nitrite. On the other hand, nitrate but not nitrite causes a rapid enzyme activation, explaining the higher Nap activity found in nitrate-grown cells. Translational nap′-′lacZ fusions reveal that the napK and napD genes are not efficiently translated, probably due to mRNA secondary structures occluding the translation initiation sites of these genes. Neither butyrate nor caproate increases nap expression, although cells growing phototrophically on these reduced substrates show a very high Nap activity in vivo (nitrite accumulation is sevenfold higher than in medium with malate). Phototrophic growth on butyrate or caproate medium is severely reduced in the NapA− mutants. Taken together, these results indicate that nitrate reduction in R. sphaeroides is mainly regulated at the level of enzyme activity by both nitrate and electron supply and confirm that the Nap system is involved in redox balancing using nitrate as an ancillary oxidant to dissipate excess reductant. PMID:11872721

  14. Identification of Peach NAP Transcription Factor Genes and Characterization of their Expression in Vegetative and Reproductive Organs during Development and Senescence

    PubMed Central

    Li, Fang; Li, Jinjin; Qian, Ming; Han, Mingyu; Cao, Lijun; Liu, Hangkong; Zhang, Dong; Zhao, Caiping

    2016-01-01

    The NAP (NAC-like, activated by AP3/P1) transcription factor belongs to a subfamily of the NAC transcription factor family, and is believed to have an important role in regulating plant growth and development. However, there is very little information about this subfamily in Rosaceous plants. We identified seven NAP genes in the peach genome. PpNAP2 was categorized in the NAP I group, and contained a conserved transcription activation region. The other PpNAP genes belonged to the NAP II group. The expression patterns of the PpNAP genes differed in various organs and developmental stages. PpNAP1 and PpNAP2 were highly expressed in mature and senescing flowers, but not in leaves, fruits, and flower buds. PpNAP3 and PpNAP5 were only expressed in leaves. The PpNAP4 expression level was high in mature and senescing fruits, while PpNAP6 and PpNAP7 expression was up-regulated in mature and senescent leaves and flowers. During the fruit development period, the PpNAP4 and PpNAP6 expression levels rapidly increased during the S1 and S4 stages, which suggests these genes are involved in the first exponential growth phase and fruit ripening. During the fruit ripening and softening period, the PpNAP1, PpNAP4, and PpNAP6 expression levels were high during the early storage period, which was accompanied by a rapid increase in ethylene production. PpNAP1, PpNAP4, and PpNAP6 expression slowly increased during the middle or late storage periods, and peaked at the end of the storage period. Additionally, abscisic acid (ABA)-treated fruits were softer and produced more ethylene than the controls. Furthermore, the PpNAP1, PpNAP4, and PpNAP6 expression levels were higher in ABA-treated fruits. These results suggest that PpNAP1, PpNAP4, and PpNAP6 are responsive to ABA and may regulate peach fruit ripening. PMID:26909092

  15. [Insomnia symptoms, daytime naps and physical leisure activities in the elderly: FIBRA Study Campinas].

    PubMed

    Monteiro, Natália Tonon; Neri, Anita Liberalesso; Coelim, Maria Filomena

    2014-04-01

    The practice of physical activities contributes to reducing the risk of chronic diseases and improves sleep patterns in the elderly. This research aimed to investigate the association between insomnia symptoms and daytime nap and the participation in physical leisure activities in elderly community residents. Data from the Studies Network of the Fragility in Brazilian Elderly (Campinas site), were used. Information from 689 elderly was analyzed, regarding sociodemographic characterization, physical leisure activity, occurrence of daytime napping and its duration, symptoms of insomnia and use of sleep medication. A significant association was found between the practice of walking and the daytime nap of short duration. Studies indicate that a short nap can benefit the quality of sleep and health of the elderly. Therefore, promoting the practice of walking can be a nursing intervention that favors the sleep patterns of the elderly. PMID:24918882

  16. Relational Memory: A Daytime Nap Facilitates the Abstraction of General Concepts

    PubMed Central

    Lau, Hiuyan; Alger, Sara E.; Fishbein, William

    2011-01-01

    It is increasingly evident that sleep strengthens memory. However, it is not clear whether sleep promotes relational memory, resultant of the integration of disparate memory traces into memory networks linked by commonalities. The present study investigates the effect of a daytime nap, immediately after learning or after a delay, on a relational memory task that requires abstraction of general concept from separately learned items. Specifically, participants learned English meanings of Chinese characters with overlapping semantic components called radicals. They were later tested on new characters sharing the same radicals and on explicitly stating the general concepts represented by the radicals. Regardless of whether the nap occurred immediately after learning or after a delay, the nap participants performed better on both tasks. The results suggest that sleep – even as brief as a nap – facilitates the reorganization of discrete memory traces into flexible relational memory networks. PMID:22110606

  17. [Insomnia symptoms, daytime naps and physical leisure activities in the elderly: FIBRA Study Campinas].

    PubMed

    Monteiro, Natália Tonon; Neri, Anita Liberalesso; Coelim, Maria Filomena

    2014-04-01

    The practice of physical activities contributes to reducing the risk of chronic diseases and improves sleep patterns in the elderly. This research aimed to investigate the association between insomnia symptoms and daytime nap and the participation in physical leisure activities in elderly community residents. Data from the Studies Network of the Fragility in Brazilian Elderly (Campinas site), were used. Information from 689 elderly was analyzed, regarding sociodemographic characterization, physical leisure activity, occurrence of daytime napping and its duration, symptoms of insomnia and use of sleep medication. A significant association was found between the practice of walking and the daytime nap of short duration. Studies indicate that a short nap can benefit the quality of sleep and health of the elderly. Therefore, promoting the practice of walking can be a nursing intervention that favors the sleep patterns of the elderly.

  18. A High School Research-Oriented Academy

    NASA Astrophysics Data System (ADS)

    Adkins, J.

    2011-12-01

    For the past several years Deer Valley High School (Antioch, CA) has hosted a science research academy (DVSRA). This academy has promoted original student primary research in engineering, behavior science, astronomy and physics topics and initiated the school's first entries into science fair and directed a number of students into science careers. During the previous school year the Antioch Unified School District has supported the expansion of the academy into a general research academy encompassing all areas of science and humanities, a move into a new building, purchase of a new planetarium and the development of a collegiate academy model making it easier to integrate the academy into the larger school's academic program. The presentation will discuss the design of the academy and the involvement of students in projects connected to the Teachers in Space Suborbital Flight Opportunity program, NASA's WISE, Mars Global Surveyor, Spitzer, and other missions.

  19. Histone chaperone NAP1 mediates sister chromatid resolution by counteracting protein phosphatase 2A.

    PubMed

    Moshkin, Yuri M; Doyen, Cecile M; Kan, Tsung-Wai; Chalkley, Gillian E; Sap, Karen; Bezstarosti, Karel; Demmers, Jeroen A; Ozgur, Zeliha; van Ijcken, Wilfred F J; Verrijzer, C Peter

    2013-01-01

    Chromosome duplication and transmission into daughter cells requires the precisely orchestrated binding and release of cohesin. We found that the Drosophila histone chaperone NAP1 is required for cohesin release and sister chromatid resolution during mitosis. Genome-wide surveys revealed that NAP1 and cohesin co-localize at multiple genomic loci. Proteomic and biochemical analysis established that NAP1 associates with the full cohesin complex, but it also forms a separate complex with the cohesin subunit stromalin (SA). NAP1 binding to cohesin is cell-cycle regulated and increases during G2/M phase. This causes the dissociation of protein phosphatase 2A (PP2A) from cohesin, increased phosphorylation of SA and cohesin removal in early mitosis. PP2A depletion led to a loss of centromeric cohesion. The distinct mitotic phenotypes caused by the loss of either PP2A or NAP1, were both rescued by their concomitant depletion. We conclude that the balanced antagonism between NAP1 and PP2A controls cohesin dissociation during mitosis. PMID:24086141

  20. Nap1 and Chz1 have separate Htz1-nuclear import and assembly functions

    PubMed Central

    Straube, Korinna; Blackwell, Jeffrey S.; Pemberton, Lucy F.

    2010-01-01

    We analyzed the nuclear import and regulation of the yeast histone variant Htz1 (H2A.Z), and the role of histone chaperones Nap1 and Chz1 in this process. Co-purification suggested that Htz1 and H2B dimerized in the cytoplasm prior to import. Like H2B, Htz1 contained an NLS in its N-terminus that is recognized by multiple karyopherins (also called importins), indicating multiple transport pathways into the nucleus. However, Kap114 and Kap123 appeared to play the major role in Htz1 import. We also identified a role for Nap1 in the import of Htz1/H2B heterodimers, and Nap1 formed a Ran-GTP insensitive import complex with Htz1/H2B and Kap114. Nap1 was necessary for maintaining a soluble pool of Htz1, indicating that its chaperone function may be important for the dynamic exchange of histones within nucleosomes. In contrast, Chz1 was imported by a distinct import pathway, and Chz1 did not appear to interact with Htz1 the cytoplasm. Genetic analysis indicated that NAP1 has a function in the absence of HTZ1 that is not shared with CHZ1. This provides further evidence that the histone chaperones Nap1 and Chz1 have separate Htz1-dependent and -independent functions. PMID:19929865

  1. Napping and Nighttime Sleep: Findings From an Occupation-Based Intervention

    PubMed Central

    Fogelberg, Donald; Sleight, Alix; Mallinson, Trudy; Vigen, Cheryl; Blanchard, Jeanine; Carlson, Mike; Clark, Florence

    2016-01-01

    OBJECTIVE. To describe sleeping behaviors and trends over time among an ethnically diverse group of community-living older adults. METHOD. A descriptive secondary data analysis of a subsample (n = 217) from the Lifestyle Redesign randomized controlled trial was done to explore baseline napping and sleeping patterns as well as 6-mo changes in these outcomes. RESULTS. At baseline, the average time sleeping was 8.2 hr daily (standard deviation = 1.7). Among all participants, 29% reported daytime napping at baseline, of which 36% no longer napped at follow-up. Among participants who stopped napping, those who received an occupation-based intervention (n = 98) replaced napping time with nighttime sleep, and those not receiving an intervention (n = 119) experienced a net loss of total sleep (p < .05). CONCLUSION. Among participants who stopped napping, the occupation-based intervention may be related to enhanced sleep. More research examining the role of occupation-based interventions in improving sleep is warranted. PMID:27294991

  2. Risperidone and NAP protect cognition and normalize gene expression in a schizophrenia mouse model.

    PubMed

    Vaisburd, Sinaya; Shemer, Zeev; Yeheskel, Adva; Giladi, Eliezer; Gozes, Illana

    2015-11-10

    Mutated disrupted in schizophrenia 1 (DISC1), a microtubule regulating protein, leads to schizophrenia and other psychiatric illnesses. It is hypothesized that microtubule stabilization may provide neuroprotection in schizophrenia. The NAP (NAPVSIPQ) sequence of activity-dependent neuroprotective protein (ADNP) contains the SxIP motif, microtubule end binding (EB) protein target, which is critical for microtubule dynamics leading to synaptic plasticity and neuroprotection. Bioinformatics prediction for FDA approved drugs mimicking SxIP-like motif which displace NAP-EB binding identified Risperidone. Risperidone or NAP effectively ameliorated object recognition deficits in the mutated DISC1 mouse model. NAP but not Risperidone, reduced anxiety in the mutated mice. Doxycycline, which blocked the expression of the mutated DISC1, did not reverse the phenotype. Transcripts of Forkhead-BOX P2 (Foxp2), a gene regulating DISC1 and associated with human ability to acquire a spoken language, were increased in the hippocampus of the DISC1 mutated mice and were significantly lowered after treatment with NAP, Risperidone, or the combination of both. Thus, the combination of NAP and standard of care Risperidone in humans may protect against language disturbances associated with negative and cognitive impairments in schizophrenia.

  3. Diminished nap effects on memory consolidation are seen under oral contraceptive use.

    PubMed

    Genzel, Lisa; Bäurle, Anna; Potyka, Alina; Wehrle, Renate; Adamczyk, Marek; Friess, Elisabeth; Steiger, Axel; Dresler, Martin

    2014-01-01

    Many young females take exogenous hormones as oral contraceptive (OC), a condition rarely controlled for in studies on sleep and memory consolidation even though sex hormones influence consolidation. This study investigated the effects of OCs on sleep-related consolidation of a motor and declarative task, utilizing a daytime nap protocol. Fifteen healthy, young females taking OCs came to the sleep lab for three different conditions: nap with previous learning, wake with previous learning and nap without learning. They underwent each condition twice, once during the "pill-active" weeks and once during the "pill-free" week, resulting in 6 visits. In all conditions, participants showed a significant off-line consolidation effect, independent of pill week or nap/wake condition. There were no significant differences in sleep stage duration, spindle activity or spectral EEG frequency bands between naps with or without the learning condition. The present data showed a significant off-line enhancement in memory irrespective of potential beneficial effects of a nap. In comparison to previous studies, this may suggest that the use of OCs may enhance off-line memory consolidation in motor and verbal tasks per se. These results stress the importance to control for the use of OCs in studies focusing on memory performance. PMID:25720656

  4. Physical Fitness of Police Academy Cadets: Baseline Characteristics and Changes During a 16-Week Academy

    PubMed Central

    Sherman, Ross A.; Crawley, William R.; Cosio-Lima, Ludmila M.

    2016-01-01

    Abstract Crawley, AA, Sherman, RA, Crawley, WR, and Cosio-Lima, LM. Physical fitness of police academy cadets: baseline characteristics and changes during a 16-week academy. J Strength Cond Res 30(5): 1416–1424, 2016—Police academies traditionally emphasize the importance of being physically fit. The purpose of this research was to determine cadet baseline physical fitness characteristics and assess effectiveness of a 16-week training program. Sixty-eight cadets (61 men, 7 women) volunteered to have baseline physical fitness characteristics assessed, and 55 cadets (49 men, 6 women) completed further testing at weeks 8 and 16. The testing comprised hand grip (strength), arm crank (upper-body power), 30 seconds Wingate (lower body power), sum of skinfolds and percentage body fat (body composition), 40-yard dash (sprint speed), 1 repetition maximum bench press (strength), T-test (agility), and sit-and-reach (flexibility). In addition, cadets completed standardized state testing (push-ups, sit-ups, vertical jump, and half-mile shuttle run). The training program consisted of 1 hour sessions, 3 d·wk−1, including aerobic, plyometrics, body weight, and resistance exercise. Significant changes were found in agility (p < 0.01), upper-body and lower-body peak power (p ≤ 0.05), sit-ups (p < 0.01), push-ups (p ≤ 0.05) across the first 8 weeks, and in agility (p ≤ 0.05), lower-body peak power (p ≤ 0.05), sit-ups (p < 0.01), push-ups (p ≤ 0.05), half-mile shuttle run (p < 0.01) across the full 16 weeks. However, none of the variables showed significant change across the second half of the program (weeks 8–16). A number of individual parameters of physical fitness showed evidence of improvement in the first 8 weeks, whereas none of the variables showed significant improvement in the second 8 weeks. This suggests modifications could be made to increase overall effectiveness of cadet physical training specifically after the 8-week mark. PMID:26466133

  5. [Modern medical science and Military Medical Academy].

    PubMed

    Gaĭdar, B V; Lobzin, Iu V; Chursin, I G; Tsygan, V N

    2005-08-01

    The article presents the information about the main directions of scientific investigations of Military Medical Academy and their results during the period of 1999-2000. The scientific work was conducted in conformity with demands of orders and directives of RF Ministry of Defense. 12 integrated scientific problems were formed in the annual plans of the Academy's research work. Together with traditional directions the new ones connected with the experience of troops medical support during the armed conflicts, liquidation of consequences of extreme situations, participation of military contingents in peace-making operations were developed. The complex clinical investigations of specific features of combat pathology due to firearms used by the enemy during the military operations in Afghanistan and in the Northern Caucasus are going on. In the most of clinical departments the problems of etiology, pathogenesis and treatment of servicemen' diseases under peacetime conditions are the main directions of scientific investigations. Every year the Academy's rationalizers and inventors produce 60-70 inventions and more than 500 rationalization proposals. Since 1995 the Academy publishes the journal "Clinical medicine and pathophysiology" and since 1999--"Bulletin of Russian Military Medical Academy". The Academy's scientific potential comprises 194 professors, 295 associate professors, 349 Doctors and 894 Candidates of Science, 20 Honoured Scientists of RF, 57 members and corresponding members of academies (Russian Academy of Medical Sciences, Russian Academy of Natural Sciences and other social academies). PMID:16259295

  6. A Guide to Press Relations.

    ERIC Educational Resources Information Center

    Fibre Box Association, Chicago, IL.

    Stressing that a positive press-relations program can be extremely helpful to businesses, this publication offers suggestions for establishing press contacts, preparing press releases, holding press conferences, illustrating a story, preparing materials for use in radio and television broadcasts, and developing policies to be followed in emergency…

  7. Reconsidering the Sporulation Characteristics of Hypervirulent Clostridium difficile BI/NAP1/027

    PubMed Central

    Cartman, Stephen T.; Minton, Nigel P.

    2011-01-01

    Clostridium difficile is the leading cause of antibiotic-associated diarrhoea and a major burden to healthcare services worldwide. In recent years, C. difficile strains belonging to the BI/NAP1/027 type have become highly represented among clinical isolates. These so-called ‘hypervirulent’ strains are associated with outbreaks of increased disease severity, higher relapse rates and an expanded repertoire of antibiotic resistance. Spores, formed during sporulation, play a pivotal role in disease transmission and it has been suggested that BI/NAP1/027 strains are more prolific in terms of sporulation in vitro than ‘non-epidemic’ C. difficile types. Work in our laboratory has since provided credible evidence to the contrary suggesting that the strain-to-strain variation in C. difficile sporulation characteristics is not type-associated. However, the BI/NAP1/027 type is still widely stated to have an increased rate of sporulation. In this study, we analysed the sporulation rates of 53 C. difficile strains, the largest sample size used to-date in such a study, including 28 BI/NAP1/027 isolates. Our data confirm that significant variation exists in the rate at which different C. difficile strains form spores. However, we clearly show that the sporulation rate of the BI/NAP1/027 type was no higher than that of non-BI/NAP1/027 strains. In addition, we observed substantial variation in sporulation characteristics within the BI/NAP1/027 type. This work highlights the danger of assuming that all strains of one type behave similarly without studying adequate sample sizes. Furthermore, we stress the need for more rigorous experimental procedures in order to quantify C. difficile sporulation more accurately in the future. PMID:21949780

  8. Relationship between napping during night shift work and household obligations of female nursing personnel.

    PubMed

    Silva-Costa, Aline; Fischer, Frida Marina; Griep, Rosane Harter; Rotenberg, Lúcia

    2013-01-01

    Night shift employment involves displacing sleep to the daytime. For female workers, the opportunity for daytime sleep is influenced by routine housework demands, which aggravates sleep deprivation. Allowing naps to be taken during the night shift of work is a frequent practice at some hospitals and can help reduce the effects of sleep deprivation. We hypothesize that an association between domestic work and the length of naps during night work exists for nursing professionals. To test this hypothesis, two cross-sectional studies were conducted in two different hospitals. In Study 1, female workers answered questionnaires regarding sleeping habits, professional work, and housework demands. In Study 2, data regarding napping during shifts was obtained by actigraphy, a noninvasive method of monitoring the human sleep-wake cycle. The demand for the performance of housework was measured by (i) domestic work hours (total time spent performing domestic work per week), and (ii) domestic workload, which considers the degree of sharing domestic tasks and the number of people living at home. The populations from the two studies were subdivided into groups, based on the duration of napping at work. Data on naps were analyzed according to domestic demands, using the Mann-Whitney and Chi-squared tests. Among the two study populations (Studies 1 and 2), those in Study 2 were older, had shorter professional weekly work hours, worked more night shifts, and dedicated more time to housework. significant associations were only found in Study 2, where greater time napping at work was associated with both greater time spent doing housework and greater domestic workload. The known benefits of napping during night shifts seem to be especially relevant for female workers who are more sleep-deprived from working more night shifts and who have higher demands for housework.

  9. Effects of Two 15-min Naps on the Subjective Sleepiness, Fatigue and Heart Rate Variability of Night Shift Nurses

    PubMed Central

    ORIYAMA, Sanae; MIYAKOSHI, Yukiko; KOBAYASHI, Toshio

    2013-01-01

    The purpose of this study was to examine the effects of two 15-min naps on nurses who work at night in a three-shift system. Of the 15 nurses who were included as study subjects on a night shift, eight took two short naps (the Nap condition), and seven worked without taking a nap (the No-nap condition) during the night shift. We measured sublingual temperature and the bispectral index (BIS), obtained heart rate and heart rate variability measures from an electrocardiogram (ECG), and evaluated sleepiness and fatigue levels every hour using the Visual Analog Scale (VAS). Both subjective sleepiness and fatigue increased between 4:00 and 5:00, with no significant differences observed between the two groups. However, the low- to high-frequency ratio (LF/HF) in the Nap condition group was found to be significantly lower than in the No-nap condition group. Furthermore, a sudden, brief increase in HF values was observed in the No-nap condition group in the morning. The results of this study suggest that taking two short naps may effectively reduce tension and prevent a brief increase in HF values by suppressing sympathetic nervous activity in the morning. PMID:24292879

  10. Glutamylation of Nap1 modulates histone H1 dynamics and chromosome condensation in Xenopus.

    PubMed

    Miller, Kelly E; Heald, Rebecca

    2015-04-27

    Linker histone H1 is required for mitotic chromosome architecture in Xenopus laevis egg extracts and, unlike core histones, exhibits rapid turnover on chromatin. Mechanisms regulating the recruitment, deposition, and dynamics of linker histones in mitosis are largely unknown. We found that the cytoplasmic histone chaperone nucleosome assembly protein 1 (Nap1) associates with the embryonic isoform of linker histone H1 (H1M) in egg extracts. Immunodepletion of Nap1 decreased H1M binding to mitotic chromosomes by nearly 50%, reduced H1M dynamics as measured by fluorescence recovery after photobleaching and caused chromosome decondensation similar to the effects of H1M depletion. Defects in H1M dynamics and chromosome condensation were rescued by adding back wild-type Nap1 but not a mutant lacking sites subject to posttranslational modification by glutamylation. Nap1 glutamylation increased the deposition of H1M on sperm nuclei and chromatin-coated beads, indicating that charge-shifting posttranslational modification of Nap1 contributes to H1M dynamics that are essential for higher order chromosome architecture. PMID:25897082

  11. NAP1 family histone chaperones are required for somatic homologous recombination in Arabidopsis.

    PubMed

    Gao, Juan; Zhu, Yan; Zhou, Wangbin; Molinier, Jean; Dong, Aiwu; Shen, Wen-Hui

    2012-04-01

    Homologous recombination (HR) is essential for maintaining genome integrity and variability. To orchestrate HR in the context of chromatin is a challenge, both in terms of DNA accessibility and restoration of chromatin organization after DNA repair. Histone chaperones function in nucleosome assembly/disassembly and could play a role in HR. Here, we show that the NUCLEOSOME ASSEMBLY PROTEIN1 (NAP1) family histone chaperones are required for somatic HR in Arabidopsis thaliana. Depletion of either the NAP1 group or NAP1-RELATED PROTEIN (NRP) group proteins caused a reduction in HR in plants under normal growth conditions as well as under a wide range of genotoxic or abiotic stresses. This contrasts with the hyperrecombinogenic phenotype caused by the depletion of the CHROMATIN ASSEMBLY FACTOR-1 (CAF-1) histone chaperone. Furthermore, we show that the hyperrecombinogenic phenotype caused by CAF-1 depletion relies on NRP1 and NRP2, but the telomere shortening phenotype does not. Our analysis of DNA lesions, H3K56 acetylation, and expression of DNA repair genes argues for a role of NAP1 family histone chaperones in nucleosome disassembly/reassembly during HR. Our study highlights distinct functions for different families of histone chaperones in the maintenance of genome stability and establishes a crucial function for NAP1 family histone chaperones in somatic HR. PMID:22534127

  12. Motor Performance Is not Enhanced by Daytime Naps in Older Adults

    PubMed Central

    Backhaus, Winifried; Braass, Hanna; Renné, Thomas; Gerloff, Christian; Hummel, Friedhelm C.

    2016-01-01

    The impact of sleep on motor learning in the aging brain was investigated using an experimental diurnal nap setup. As the brain ages several components of learning as well as motor performance change. In addition, aging is also related to sleep architectural changes. This combination of slowed learning processes and impaired sleep behavior raises the question of whether sleep can enhance learning and specifically performance of procedural tasks in healthy, older adults. Previous research was able to show sleep-dependent consolidation overnight for numerous tasks in young adults. Some of these study findings can also be replicated for older adults. This study aims to clarify whether sleep-dependent consolidation can also be found during shorter periods of diurnal sleep. The impact of midday naps on motor consolidation was analyzed by comparing procedural learning using a sequence and a motor adaptation task, in a crossover fashion in healthy, non-sleep deprived, older adults randomly subjected to wake (45 min), short nap (10–20 min sleep) or long nap (50–70 min sleep) conditions. Older adults exhibited learning gains, these were not found to be sleep-dependent in either task. The results suggest that daytime naps do not have an impact on performance and motor learning in an aging population. PMID:27303292

  13. Sleeping pattern of kindergartners and nursery school children: function of daytime nap.

    PubMed

    Fukuda, Kazuhiko; Sakashita, Yukine

    2002-02-01

    With a questionnaire answered by parents this study investigated the sleeping pattern of children attending kindergartens or nursery schools and the function of an afternoon nap. Sleeping pattern was investigated by a questionnaire with 441 young children (229 boys and 212 girls) attending kindergartens or nursery schools at the ages of 3 to 6 years old. Nighttime sleep did not show any significant change, while daytime naps decreased drastically and almost disappeared by the age of 6. Nursery school children went to bed later at night, so nighttime sleep was shorter than that of kindergartners. They also reported having more 'difficulty to fall asleep', more frequent 'staying-up at late night', less 'not getting enough sleep', worse 'mood at rising', and more 'unwillingness to go to their schools'. To investigate whether afternoon naps, which are routine at Japanese nursery schools, can compensate for sleep insufficiency on the previous night and whether they have the effect of delaying the onset of the subsequent nighttime sleep, we compared sleep duration on the previous night and the sleep onset time between the days with and without an afternoon nap. The afternoon nap appeared to cause delayed sleep onset but was not a result of sleep deficiency. PMID:11883566

  14. The effects of biperiden on nap sleep after sleep deprivation in depressed patients.

    PubMed

    Dressing, H; Riemann, D; Gann, H; Berger, M

    1992-08-01

    Sixteen patients with a major depressive disorder were allowed to take a nap at 5 A.M. after a period of total sleep deprivation. The patients were randomly assigned to biperiden or placebo treatment prior to the nap to test the hypothesis that anticholinergic medication is capable of preventing a nap-related worsening of mood. Total sleep deprivation positively influenced mood for the whole group. Contrary to expectations, the rate of nap-related relapses of mood did not differ between placebo- and biperiden-treated individuals, and biperiden did not significantly suppress rapid eye movement (REM) sleep. There was only a tendency for lower REM time after administration of biperiden compared to placebo. This unexpected result may be due to a high cholinergic tone in the patient group investigated and a high REM propensity in the early morning hours. Studies with more selective M1/M2 receptor antagonists are necessary to clarify whether nap-related changes of mood can be prevented by anticholinergic blockade.

  15. Motor Performance Is not Enhanced by Daytime Naps in Older Adults.

    PubMed

    Backhaus, Winifried; Braass, Hanna; Renné, Thomas; Gerloff, Christian; Hummel, Friedhelm C

    2016-01-01

    The impact of sleep on motor learning in the aging brain was investigated using an experimental diurnal nap setup. As the brain ages several components of learning as well as motor performance change. In addition, aging is also related to sleep architectural changes. This combination of slowed learning processes and impaired sleep behavior raises the question of whether sleep can enhance learning and specifically performance of procedural tasks in healthy, older adults. Previous research was able to show sleep-dependent consolidation overnight for numerous tasks in young adults. Some of these study findings can also be replicated for older adults. This study aims to clarify whether sleep-dependent consolidation can also be found during shorter periods of diurnal sleep. The impact of midday naps on motor consolidation was analyzed by comparing procedural learning using a sequence and a motor adaptation task, in a crossover fashion in healthy, non-sleep deprived, older adults randomly subjected to wake (45 min), short nap (10-20 min sleep) or long nap (50-70 min sleep) conditions. Older adults exhibited learning gains, these were not found to be sleep-dependent in either task. The results suggest that daytime naps do not have an impact on performance and motor learning in an aging population. PMID:27303292

  16. Press-On Optics

    ERIC Educational Resources Information Center

    Thorson, Jon C.

    1972-01-01

    The article discusses the design, application, and clinical uses of press-on optics which are descirbed as 1 millimeter thick, flexible lenses or prisms that may be produced in virtually any desired plus or minus dioptric power as ophthalmic lenses, or in any range of usable prism diopter power. (GW)

  17. Optically Aligned Drill Press

    NASA Technical Reports Server (NTRS)

    Adderholdt, Bruce M.

    1994-01-01

    Precise drill press equipped with rotary-indexing microscope. Microscope and drill exchange places when turret rotated. Microscope axis first aligned over future hole, then rotated out of way so drill axis assumes its precise position. New procedure takes less time to locate drilling positions and produces more accurate results. Apparatus adapted to such other machine tools as milling and measuring machines.

  18. Reinventing the University Press.

    ERIC Educational Resources Information Center

    Bryant, Eric

    1994-01-01

    Discusses how librarians and university press staffers could cooperate to improve the scholarly communication system. Causes of system decline, the environment for cooperation, several change models, possible changes to the publish or perish tenure system, and the probability of a slow transition to a new scholarly communications model are…

  19. Slow wave sleep during a daytime nap is necessary for protection from subsequent interference and long-term retention.

    PubMed

    Alger, Sara E; Lau, Hiuyan; Fishbein, William

    2012-09-01

    While it is now generally accepted that sleep facilitates the processing of newly acquired declarative information, questions still remain as to the type and length of sleep necessary to best benefit declarative memories. A better understanding could lend support in one direction or another as to the much-debated role of sleep, be it passive, permissive, or active, in memory processing. The present study employed a napping paradigm and compared performance on a bimodal paired-associates task of those who obtained a 10-min nap, containing only Stages 1 and 2 sleep, to those whose nap contained slow-wave sleep (SWS) and rapid eye movement (REM) sleep (60-min nap), as well as to subjects who remained awake. Measurements were obtained for baseline performance at training, after a sleep/no sleep interval for short-term retention, after a subsequent stimulus-related interference task, and again after a weeklong retention period. While all groups learned the information similarly, both nap groups performed better than the Wake group when examining short-term retention, approximately 1.5h after training (10-min p=.052, 60-min p=.002). However, performance benefits seen in the 10-min nap group proved to be temporary. Performance after a stimulus-related interference task revealed significantly better memory retention in the 60-min nap group, with interference disrupting the memory trace far less than both the Wake and 10-min nap groups (p<.001, p=.006, respectively). After a weeklong retention period, sleep's benefit to memory persisted in the 60-min nap group, with performance significantly greater than both the Wake and 10-min nap groups (p<.001, p=.004, respectively). It is our conclusion that SWS, obtained only by those in the 60-min nap group, served to actively facilitate the consolidation of learned bimodal paired-associates, supported by theories such as the Standard Theory of Consolidation as well as the Synaptic Homeostasis Hypothesis.

  20. Slow wave sleep during a daytime nap is necessary for protection from subsequent interference and long-term retention.

    PubMed

    Alger, Sara E; Lau, Hiuyan; Fishbein, William

    2012-09-01

    While it is now generally accepted that sleep facilitates the processing of newly acquired declarative information, questions still remain as to the type and length of sleep necessary to best benefit declarative memories. A better understanding could lend support in one direction or another as to the much-debated role of sleep, be it passive, permissive, or active, in memory processing. The present study employed a napping paradigm and compared performance on a bimodal paired-associates task of those who obtained a 10-min nap, containing only Stages 1 and 2 sleep, to those whose nap contained slow-wave sleep (SWS) and rapid eye movement (REM) sleep (60-min nap), as well as to subjects who remained awake. Measurements were obtained for baseline performance at training, after a sleep/no sleep interval for short-term retention, after a subsequent stimulus-related interference task, and again after a weeklong retention period. While all groups learned the information similarly, both nap groups performed better than the Wake group when examining short-term retention, approximately 1.5h after training (10-min p=.052, 60-min p=.002). However, performance benefits seen in the 10-min nap group proved to be temporary. Performance after a stimulus-related interference task revealed significantly better memory retention in the 60-min nap group, with interference disrupting the memory trace far less than both the Wake and 10-min nap groups (p<.001, p=.006, respectively). After a weeklong retention period, sleep's benefit to memory persisted in the 60-min nap group, with performance significantly greater than both the Wake and 10-min nap groups (p<.001, p=.004, respectively). It is our conclusion that SWS, obtained only by those in the 60-min nap group, served to actively facilitate the consolidation of learned bimodal paired-associates, supported by theories such as the Standard Theory of Consolidation as well as the Synaptic Homeostasis Hypothesis. PMID:22732649

  1. Clinical Utility of Laboratory Detection of Clostridium difficile Strain BI/NAP1/027

    PubMed Central

    Gerding, Dale N.

    2015-01-01

    Clostridium difficile strain BI/NAP1/027 is associated with increased C. difficile infection (CDI) rates and severity, and the efficacy of some CDI therapies may be strain dependent. Although cultured C. difficile isolates can be reliably subtyped by various methods, the long turnaround times, high cost, and limited availability of strain typing preclude their routine use. Nucleic acid amplification tests identify BI/NAP1/027 rapidly from stool, but the emergence of closely related strains compromises test specificity. Although detection of epidemiologically significant pathogens is generally useful for infection control programs, specific data supporting use of rapid detection of BI/NAP1/027 as an infection control tool are still awaited. PMID:26511742

  2. Clinical Utility of Laboratory Detection of Clostridium difficile Strain BI/NAP1/027.

    PubMed

    Kociolek, Larry K; Gerding, Dale N

    2016-01-01

    Clostridium difficile strain BI/NAP1/027 is associated with increased C. difficile infection (CDI) rates and severity, and the efficacy of some CDI therapies may be strain dependent. Although cultured C. difficile isolates can be reliably subtyped by various methods, the long turnaround times, high cost, and limited availability of strain typing preclude their routine use. Nucleic acid amplification tests identify BI/NAP1/027 rapidly from stool, but the emergence of closely related strains compromises test specificity. Although detection of epidemiologically significant pathogens is generally useful for infection control programs, specific data supporting use of rapid detection of BI/NAP1/027 as an infection control tool are still awaited. PMID:26511742

  3. Naval Academy Continues Its Diversity Trend

    ERIC Educational Resources Information Center

    Cooper, Kenneth J.

    2009-01-01

    Sixty years after graduating its first Black midshipman, Wesley Brown, the U.S. Naval Academy has admitted its most diverse class, which boasts the largest numbers and percentages of African-Americans and Hispanics ever to enter Annapolis. The academy has touted the racial and ethnic composition of the class of 2013 as the result of aggressive…

  4. Academy Schools and Entrepreneurialism in Education

    ERIC Educational Resources Information Center

    Woods, Philip A.; Woods, Glenys J.; Gunter, Helen

    2007-01-01

    The academy schools programme in England is presented by Government as the means by which increased diversity and private participation in the provision of public education can be used to solve educational and wider social problems. The entrepreneurial features of academy schools are examined, through a study of the sponsors and the ethos, values…

  5. A Peace Academy to Build the Channels.

    ERIC Educational Resources Information Center

    Mapes, Milton C., Jr.

    1984-01-01

    Legislation to establish the National Peace Academy is currently under consideration by the United States Congress. The Peace Academy should develop as the center and the hub of a national and international movement to change the way our society deals with conflict. (MLW)

  6. The Career Academy Concept. OJJDP Fact Sheet.

    ERIC Educational Resources Information Center

    Coffee, Joseph N.; Pestridge, Scott

    Career academies are schools within schools that link students with peers, teachers, and community partners in a disciplined environment, thereby fostering academic success and mental and emotional health. The career academy concept includes the following three key elements: (1) small learning communities; (2) a college preparatory curriculum with…

  7. The Academy for Positive Peer Culture

    ERIC Educational Resources Information Center

    Laursen, Erik K.

    2010-01-01

    Positive Peer Culture [PPC] creates a pro-social climate in schools and youth programs by enlisting youth in helping their peers. Research and training in PPC is coordinated by the Academy for Positive Peer Culture. Established in 2006, the Academy provides networking and is a clearinghouse for resources, training, and consultation for PPC. It…

  8. Academies: A Breakthrough or Yet More Spin?

    ERIC Educational Resources Information Center

    Sinnott, Steve

    2008-01-01

    In this article the General Secretary of the National Union of Teachers outlines the reasons why the Union opposes Academies, and gives an overview of the changes in the relationship between local authorities and Academies. The NUT recognises that the change of government presents an opportunity for a change of direction and welcomes reports that…

  9. Anthropometric and Physical Profiles of English Academy Rugby Union Players.

    PubMed

    Darrall-Jones, Joshua D; Jones, Ben; Till, Kevin

    2015-08-01

    The purpose of this study was to evaluate the anthropometric and physical characteristics of English regional academy rugby union players by age category (under 16s, under 18s and under 21s). Data were collected on 67 academy players at the beginning of the preseason period and comprised anthropometric (height, body mass, and sum of 8 skinfolds) and physical (5-, 10-, 20-, and 40-m sprint, acceleration, velocity, and momentum; agility 505; vertical jump; Yo-Yo intermittent recovery test level 1; 30-15 intermittent fitness test; absolute and relative 3 repetition maximum front squat, split squat, bench press, prone row, and chin; and isometric mid-thigh pull). One-way analysis of variance demonstrated significant increases across the 3 age categories (p ≤ 0.05) for height (e.g., 16s = 178.8 ± 7.1; 18s = 183.5 ± 7.2; 21s = 186.7 ± 6.61 cm), body mass (e.g., 16s = 79.4 ± 12.8; 18s = 88.3 ± 11.9; 21s = 98.3 ± 10.4 kg), countermovement jump height and peak power, sprint momentum, velocity, and acceleration; absolute, relative, and isometric (e.g., 16s = 2,157.9 ± 309.9; 18s = 2,561.3 ± 339.4; 21s = 3,104.5 ± 354.0 N) strength. Momentum, maximal speed, and the ability to maintain acceleration were all discriminating factors between age categories, suggesting that these variables may be more important to monitor rather than sprint times. These findings highlight that anthropometric and physical characteristics develop across age categories and provide comparative data for English Academy Rugby Union players.

  10. Fatigue on the flight deck: the consequences of sleep loss and the benefits of napping.

    PubMed

    Hartzler, Beth M

    2014-01-01

    The detrimental effects of fatigue in aviation are well established, as evidenced by both the number of fatigue-related mishaps and numerous studies which have found that most pilots experience a deterioration in cognitive performance as well as increased stress during the course of a flight. Further, due to the nature of the average pilot's work schedule, with frequent changes in duty schedule, early morning starts, and extended duty periods, fatigue may be impossible to avoid. Thus, it is critical that fatigue countermeasures be available which can help to combat the often overwhelming effects of sleep loss or sleep disruption. While stimulants such as caffeine are typically effective at maintaining alertness and performance, such countermeasures do nothing to address the actual source of fatigue - insufficient sleep. Consequently, strategic naps are considered an efficacious means of maintaining performance while also reducing the individual's sleep debt. These types of naps have been advocated for pilots in particular, as opportunities to sleep either in the designated rest facilities or on the flight deck may be beneficial in reducing both the performance and alertness impairments associated with fatigue, as well as the subjective feelings of sleepiness. Evidence suggests that strategic naps can reduce subjective feelings of fatigue and improve performance and alertness. Despite some contraindications to implementing strategic naps while on duty, such as sleep inertia experienced upon awakening, both researchers and pilots agree that the benefits associated with these naps far outweigh the potential risks. This article is a literature review detailing both the health and safety concerns of fatigue among commercial pilots as well as benefits and risks associated with strategic napping to alleviate this fatigue. PMID:24215936

  11. Toddler's self-regulation strategies in a challenge context are nap-dependent.

    PubMed

    Miller, Alison L; Seifer, Ronald; Crossin, Rebecca; Lebourgeois, Monique K

    2015-06-01

    Early childhood represents a time of developmental changes in both sleep and self-regulation, a construct reflecting the ability to control one's behaviour, attention and emotions when challenged. Links between sleep and self-regulation processes have been proposed, but experimental evidence with young children is lacking. In the current study, we tested the effects of acute sleep restriction (nap deprivation) on toddlers' self-regulation. Healthy children (n = 12; four males; aged 30-36 months (33.9 ± 1.7)) slept on a strict schedule (verified with actigraphy and sleep diaries) for 5 days before each of two afternoon assessments following a nap and a no-nap condition (~11-day protocol). Children were videotaped while attempting an unsolvable puzzle, and 10 mutually exclusive self-regulation strategies were later coded. On average, children lost ~90 min of sleep on the no-nap versus the nap day. Nap deprivation resulted in moderate-to-large effects on self-regulation strategies, with decreases in scepticism (d = 0.77; 7% change), negative self-appraisal (d = 0.92; 5% change) and increases in physical self-soothing (d = 0.68; 10% change), focus on the puzzle piece that would not fit (perseveration; d = 0.50; 9% change) and insistence on completing the unsolvable puzzle (d = 0.91; 10% change). Results suggest that sleep serves an important role in the way that toddlers respond to challenging events in their daily lives. After losing daytime sleep, toddlers were less able to engage effectively in a difficult task and reverted to less mature self-regulation strategies than when they were well rested. Over time, chronically missed sleep may impair young children's self-regulation abilities, resulting in risk for social-emotional, behavioural and school problems. PMID:25394169

  12. Toddler's self-regulation strategies in a challenge context are nap-dependent.

    PubMed

    Miller, Alison L; Seifer, Ronald; Crossin, Rebecca; Lebourgeois, Monique K

    2015-06-01

    Early childhood represents a time of developmental changes in both sleep and self-regulation, a construct reflecting the ability to control one's behaviour, attention and emotions when challenged. Links between sleep and self-regulation processes have been proposed, but experimental evidence with young children is lacking. In the current study, we tested the effects of acute sleep restriction (nap deprivation) on toddlers' self-regulation. Healthy children (n = 12; four males; aged 30-36 months (33.9 ± 1.7)) slept on a strict schedule (verified with actigraphy and sleep diaries) for 5 days before each of two afternoon assessments following a nap and a no-nap condition (~11-day protocol). Children were videotaped while attempting an unsolvable puzzle, and 10 mutually exclusive self-regulation strategies were later coded. On average, children lost ~90 min of sleep on the no-nap versus the nap day. Nap deprivation resulted in moderate-to-large effects on self-regulation strategies, with decreases in scepticism (d = 0.77; 7% change), negative self-appraisal (d = 0.92; 5% change) and increases in physical self-soothing (d = 0.68; 10% change), focus on the puzzle piece that would not fit (perseveration; d = 0.50; 9% change) and insistence on completing the unsolvable puzzle (d = 0.91; 10% change). Results suggest that sleep serves an important role in the way that toddlers respond to challenging events in their daily lives. After losing daytime sleep, toddlers were less able to engage effectively in a difficult task and reverted to less mature self-regulation strategies than when they were well rested. Over time, chronically missed sleep may impair young children's self-regulation abilities, resulting in risk for social-emotional, behavioural and school problems.

  13. Rapid-Eye-Movement-Sleep (REM) Associated Enhancement of Working Memory Performance after a Daytime Nap.

    PubMed

    Lau, Esther Yuet Ying; Wong, Mark Lawrence; Lau, Kristy Nga Ting; Hui, Florence Wai Ying; Tseng, Chia-huei

    2015-01-01

    The main objective was to study the impact of a daytime sleep opportunity on working memory and the mechanism behind such impact. This study adopted an experimental design in a sleep research laboratory. Eighty healthy college students (Age:17-23, 36 males) were randomized to either have a polysomnography-monitored daytime sleep opportunity (Nap-group, n=40) or stay awake (Wake-group, n=40) between the two assessment sessions. All participants completed a sleep diary and wore an actigraph-watch for 5 days before and one day after the assessment sessions. They completed the state-measurement of sleepiness and affect, in addition to a psychomotor vigilance test and a working memory task before and after the nap/wake sessions. The two groups did not differ in their sleep characteristics prior to and after the lab visit. The Nap-group had higher accuracy on the working memory task, fewer lapses on the psychomotor vigilance test and lower state-sleepiness than the Wake-group. Within the Nap-group, working memory accuracy was positively correlated with duration of rapid eye movement sleep (REM) and total sleep time during the nap. Our findings suggested that "sleep gain" during a daytime sleep opportunity had significant positive impact on working memory performance, without affecting subsequent nighttime sleep in young adult, and such impact was associated with the duration of REM. While REM abnormality has long been noted in pathological conditions (e.g. depression), which are also presented with cognitive dysfunctions (e.g. working memory deficits), this was the first evidence showing working memory enhancement associated with REM in daytime napping in college students, who likely had habitual short sleep duration but were otherwise generally healthy. PMID:25970511

  14. Rapid-Eye-Movement-Sleep (REM) Associated Enhancement of Working Memory Performance after a Daytime Nap

    PubMed Central

    Lau, Kristy Nga Ting; Hui, Florence Wai Ying; Tseng, Chia-huei

    2015-01-01

    The main objective was to study the impact of a daytime sleep opportunity on working memory and the mechanism behind such impact. This study adopted an experimental design in a sleep research laboratory. Eighty healthy college students (Age:17-23, 36 males) were randomized to either have a polysomnography-monitored daytime sleep opportunity (Nap-group, n=40) or stay awake (Wake-group, n=40) between the two assessment sessions. All participants completed a sleep diary and wore an actigraph-watch for 5 days before and one day after the assessment sessions. They completed the state-measurement of sleepiness and affect, in addition to a psychomotor vigilance test and a working memory task before and after the nap/wake sessions. The two groups did not differ in their sleep characteristics prior to and after the lab visit. The Nap-group had higher accuracy on the working memory task, fewer lapses on the psychomotor vigilance test and lower state-sleepiness than the Wake-group. Within the Nap-group, working memory accuracy was positively correlated with duration of rapid eye movement sleep (REM) and total sleep time during the nap. Our findings suggested that “sleep gain” during a daytime sleep opportunity had significant positive impact on working memory performance, without affecting subsequent nighttime sleep in young adult, and such impact was associated with the duration of REM. While REM abnormality has long been noted in pathological conditions (e.g. depression), which are also presented with cognitive dysfunctions (e.g. working memory deficits), this was the first evidence showing working memory enhancement associated with REM in daytime napping in college students, who likely had habitual short sleep duration but were otherwise generally healthy. PMID:25970511

  15. Rapid-Eye-Movement-Sleep (REM) Associated Enhancement of Working Memory Performance after a Daytime Nap.

    PubMed

    Lau, Esther Yuet Ying; Wong, Mark Lawrence; Lau, Kristy Nga Ting; Hui, Florence Wai Ying; Tseng, Chia-huei

    2015-01-01

    The main objective was to study the impact of a daytime sleep opportunity on working memory and the mechanism behind such impact. This study adopted an experimental design in a sleep research laboratory. Eighty healthy college students (Age:17-23, 36 males) were randomized to either have a polysomnography-monitored daytime sleep opportunity (Nap-group, n=40) or stay awake (Wake-group, n=40) between the two assessment sessions. All participants completed a sleep diary and wore an actigraph-watch for 5 days before and one day after the assessment sessions. They completed the state-measurement of sleepiness and affect, in addition to a psychomotor vigilance test and a working memory task before and after the nap/wake sessions. The two groups did not differ in their sleep characteristics prior to and after the lab visit. The Nap-group had higher accuracy on the working memory task, fewer lapses on the psychomotor vigilance test and lower state-sleepiness than the Wake-group. Within the Nap-group, working memory accuracy was positively correlated with duration of rapid eye movement sleep (REM) and total sleep time during the nap. Our findings suggested that "sleep gain" during a daytime sleep opportunity had significant positive impact on working memory performance, without affecting subsequent nighttime sleep in young adult, and such impact was associated with the duration of REM. While REM abnormality has long been noted in pathological conditions (e.g. depression), which are also presented with cognitive dysfunctions (e.g. working memory deficits), this was the first evidence showing working memory enhancement associated with REM in daytime napping in college students, who likely had habitual short sleep duration but were otherwise generally healthy.

  16. The Arecibo Observatory Space Academy

    NASA Astrophysics Data System (ADS)

    Rodriguez-Ford, Linda A.; Zambrano-Marin, Luisa; Petty, Bryan M.; Sternke, Elizabeth; Ortiz, Andrew M.; Rivera-Valentin, Edgard G.

    2015-11-01

    The Arecibo Observatory Space Academy (AOSA) is a ten (10) week pre-college research program for students in grades 9-12. Our mission is to prepare students for academic and professional careers by allowing them to receive an independent and collaborative research experience on topics related to space and aide in their individual academic and social development. Our objectives are to (1) Supplement the student’s STEM education via inquiry-based learning and indirect teaching methods, (2) Immerse students in an ESL environment, further developing their verbal and written presentation skills, and (3) To foster in every student an interest in science by exploiting their natural curiosity and knowledge in order to further develop their critical thinking and investigation skills. AOSA provides students with the opportunity to share lectures with Arecibo Observatory staff, who have expertise in various STEM fields. Each Fall and Spring semester, selected high school students, or Cadets, from all over Puerto Rico participate in this Saturday academy where they receive experience designing, proposing, and carrying out research projects related to space exploration, focusing on four fields: Physics/Astronomy, Biology, Engineering, and Sociology. Cadets get the opportunity to explore their topic of choice while practicing many of the foundations of scientific research with the goal of designing a space settlement, which they present at the NSS-NASA Ames Space Settlement Design Contest. At the end of each semester students present their research to their peers, program mentors, and Arecibo Observatory staff. Funding for this program is provided by NASA SSERVI-LPI: Center for Lunar Science and Exploration with partial support from the Angel Ramos Visitor Center through UMET and management by USRA.

  17. American Academy of Facial Plastic and Reconstructive Surgery

    MedlinePlus

    ... Contact Us Shopping Cart American Academy of Facial Plastic and Reconstructive Surgery Home Meetings & Courses Find a ... About Our Academy The American Academy of Facial Plastic and Reconstructive Surgery is the world's largest specialty ...

  18. Afternoon nap and bright light exposure improve cognitive flexibility post lunch.

    PubMed

    Slama, Hichem; Deliens, Gaétane; Schmitz, Rémy; Peigneux, Philippe; Leproult, Rachel

    2015-01-01

    Beneficial effects of napping or bright light exposure on cognitive performance have been reported in participants exposed to sleep loss. Nonetheless, few studies investigated the effect of these potential countermeasures against the temporary drop in performance observed in mid-afternoon, and even less so on cognitive flexibility, a crucial component of executive functions. This study investigated the impact of either an afternoon nap or bright light exposure on post-prandial alterations in task switching performance in well-rested participants. Twenty-five healthy adults participated in two randomized experimental conditions, either wake versus nap (n=15), or bright light versus placebo (n=10). Participants were tested on a switching task three times (morning, post-lunch and late afternoon sessions). The interventions occurred prior to the post-lunch session. In the nap/wake condition, participants either stayed awake watching a 30-minute documentary or had the opportunity to take a nap for 30 minutes. In the bright light/placebo condition, participants watched a documentary under either bright blue light or dim orange light (placebo) for 30 minutes. The switch cost estimates cognitive flexibility and measures task-switching efficiency. Increased switch cost scores indicate higher difficulties to switch between tasks. In both control conditions (wake or placebo), accuracy switch-cost score increased post lunch. Both interventions (nap or bright light) elicited a decrease in accuracy switch-cost score post lunch, which was associated with diminished fatigue and decreased variability in vigilance. Additionally, there was a trend for a post-lunch benefit of bright light with a decreased latency switch-cost score. In the nap group, improvements in accuracy switch-cost score were associated with more NREM sleep stage N1. Thus, exposure to bright light during the post-lunch dip, a countermeasure easily applicable in daily life, results in similar beneficial effects as

  19. Afternoon Nap and Bright Light Exposure Improve Cognitive Flexibility Post Lunch

    PubMed Central

    Schmitz, Rémy; Peigneux, Philippe; Leproult, Rachel

    2015-01-01

    Beneficial effects of napping or bright light exposure on cognitive performance have been reported in participants exposed to sleep loss. Nonetheless, few studies investigated the effect of these potential countermeasures against the temporary drop in performance observed in mid-afternoon, and even less so on cognitive flexibility, a crucial component of executive functions. This study investigated the impact of either an afternoon nap or bright light exposure on post-prandial alterations in task switching performance in well-rested participants. Twenty-five healthy adults participated in two randomized experimental conditions, either wake versus nap (n=15), or bright light versus placebo (n=10). Participants were tested on a switching task three times (morning, post-lunch and late afternoon sessions). The interventions occurred prior to the post-lunch session. In the nap/wake condition, participants either stayed awake watching a 30-minute documentary or had the opportunity to take a nap for 30 minutes. In the bright light/placebo condition, participants watched a documentary under either bright blue light or dim orange light (placebo) for 30 minutes. The switch cost estimates cognitive flexibility and measures task-switching efficiency. Increased switch cost scores indicate higher difficulties to switch between tasks. In both control conditions (wake or placebo), accuracy switch-cost score increased post lunch. Both interventions (nap or bright light) elicited a decrease in accuracy switch-cost score post lunch, which was associated with diminished fatigue and decreased variability in vigilance. Additionally, there was a trend for a post-lunch benefit of bright light with a decreased latency switch-cost score. In the nap group, improvements in accuracy switch-cost score were associated with more NREM sleep stage N1. Thus, exposure to bright light during the post-lunch dip, a countermeasure easily applicable in daily life, results in similar beneficial effects as

  20. The Effects of a Nighttime Nap on the Error-Monitoring Functions During Extended Wakefulness

    PubMed Central

    Asaoka, Shoichi; Fukuda, Kazuhiko; Murphy, Timothy I.; Abe, Takashi; Inoue, Yuichi

    2012-01-01

    Study Objectives: To examine the effects of a 1-hr nighttime nap, and the associated sleep inertia, on the error-monitoring functions during extended wakefulness using the 2 event-related potential components thought to reflect error detection and emotional or motivational evaluation of the error, i.e., the error-related negativity/error-negativity (ERN/Ne) and error-positivity (Pe), respectively. Design: Participants awakened at 07:00 the morning of the experimental day, and performed a stimulus-response compatibility (arrow-orientation) task at 21:00, 02:00, and 03:00. Setting: A cognitive task with EEG data recording was performed in a laboratory setting. Participants: Twenty young adults (mean age 21.3 ± 1.0 yr, 14 males) participated. Interventions: Half of the participants took a 1-hr nap, and the others had a 1-hr awake-rest period from 01:00-02:00. Measurements and Results: Behavioral performance and amplitude of the Pe declined after midnight (i.e., 02:00 and 03:00) compared with the 21:00 task period in both groups. During the task period starting at 03:00, the participants in the awake-rest condition reported less alertness and showed fewer correct responses than those who napped. However, there were no effects of a nap on the amplitude of the ERN/Ne or Pe. Conclusions: Our results suggest that a 1-hr nap can alleviate the decline in subjective alertness and response accuracy during nighttime; however, error-monitoring functions, especially emotional or motivational evaluation of the error, might remain impaired by extended wakefulness even after the nap. This phenomenon could imply that night-shift workers experiencing extended wakefulness should not overestimate the positive effects of a nighttime 1-hr nap during extended wakefulness. Citation: Asaoka S; Fukuda K; Murphy TI; Abe T; Inoue Y. The effects of a nighttime nap on the error-monitoring functions during extended wakefulness. SLEEP 2012;35(6):871-878. PMID:22654206

  1. A Brief Nap Is Beneficial for Human Route-Learning: The Role of Navigation Experience and EEG Spectral Power

    ERIC Educational Resources Information Center

    Wamsley, Erin J.; Tucker, Matthew A.; Payne, Jessica D.; Stickgold, Robert

    2010-01-01

    Here, we examined the effect of a daytime nap on changes in virtual maze performance across a single day. Participants either took a short nap or remained awake following training on a virtual maze task. Post-training sleep provided a clear performance benefit at later retest, but only for those participants with prior experience navigating in a…

  2. KSHV encoded LANA recruits Nucleosome Assembly Protein NAP1L1 for regulating viral DNA replication and transcription

    NASA Astrophysics Data System (ADS)

    Gupta, Namrata; Thakker, Suhani; Verma, Subhash C.

    2016-09-01

    The establishment of latency is an essential for lifelong persistence and pathogenesis of Kaposi’s sarcoma-associated herpesvirus (KSHV). Latency-associated nuclear antigen (LANA) is the most abundantly expressed protein during latency and is important for viral genome replication and transcription. Replication-coupled nucleosome assembly is a major step in packaging the newly synthesized DNA into chromatin, but the mechanism of KSHV genome chromatinization post-replication is not understood. Here, we show that nucleosome assembly protein 1-like protein 1 (NAP1L1) associates with LANA. Our binding assays revealed an association of LANA with NAP1L1 in KSHV-infected cells, which binds through its amino terminal domain. Association of these proteins confirmed their localization in specific nuclear compartments of the infected cells. Chromatin immunoprecipitation assays from NAP1L1-depleted cells showed LANA-mediated recruitment of NAP1L1 at the terminal repeat (TR) region of the viral genome. Presence of NAP1L1 stimulated LANA-mediated DNA replication and persistence of a TR-containing plasmid. Depletion of NAP1L1 led to a reduced nucleosome positioning on the viral genome. Furthermore, depletion of NAP1L1 increased the transcription of viral lytic genes and overexpression decreased the promoter activities of LANA-regulated genes. These results confirmed that LANA recruitment of NAP1L1 helps in assembling nucleosome for the chromatinization of newly synthesized viral DNA.

  3. KSHV encoded LANA recruits Nucleosome Assembly Protein NAP1L1 for regulating viral DNA replication and transcription

    PubMed Central

    Gupta, Namrata; Thakker, Suhani; Verma, Subhash C.

    2016-01-01

    The establishment of latency is an essential for lifelong persistence and pathogenesis of Kaposi’s sarcoma-associated herpesvirus (KSHV). Latency-associated nuclear antigen (LANA) is the most abundantly expressed protein during latency and is important for viral genome replication and transcription. Replication-coupled nucleosome assembly is a major step in packaging the newly synthesized DNA into chromatin, but the mechanism of KSHV genome chromatinization post-replication is not understood. Here, we show that nucleosome assembly protein 1-like protein 1 (NAP1L1) associates with LANA. Our binding assays revealed an association of LANA with NAP1L1 in KSHV-infected cells, which binds through its amino terminal domain. Association of these proteins confirmed their localization in specific nuclear compartments of the infected cells. Chromatin immunoprecipitation assays from NAP1L1-depleted cells showed LANA-mediated recruitment of NAP1L1 at the terminal repeat (TR) region of the viral genome. Presence of NAP1L1 stimulated LANA-mediated DNA replication and persistence of a TR-containing plasmid. Depletion of NAP1L1 led to a reduced nucleosome positioning on the viral genome. Furthermore, depletion of NAP1L1 increased the transcription of viral lytic genes and overexpression decreased the promoter activities of LANA-regulated genes. These results confirmed that LANA recruitment of NAP1L1 helps in assembling nucleosome for the chromatinization of newly synthesized viral DNA. PMID:27599637

  4. KSHV encoded LANA recruits Nucleosome Assembly Protein NAP1L1 for regulating viral DNA replication and transcription.

    PubMed

    Gupta, Namrata; Thakker, Suhani; Verma, Subhash C

    2016-01-01

    The establishment of latency is an essential for lifelong persistence and pathogenesis of Kaposi's sarcoma-associated herpesvirus (KSHV). Latency-associated nuclear antigen (LANA) is the most abundantly expressed protein during latency and is important for viral genome replication and transcription. Replication-coupled nucleosome assembly is a major step in packaging the newly synthesized DNA into chromatin, but the mechanism of KSHV genome chromatinization post-replication is not understood. Here, we show that nucleosome assembly protein 1-like protein 1 (NAP1L1) associates with LANA. Our binding assays revealed an association of LANA with NAP1L1 in KSHV-infected cells, which binds through its amino terminal domain. Association of these proteins confirmed their localization in specific nuclear compartments of the infected cells. Chromatin immunoprecipitation assays from NAP1L1-depleted cells showed LANA-mediated recruitment of NAP1L1 at the terminal repeat (TR) region of the viral genome. Presence of NAP1L1 stimulated LANA-mediated DNA replication and persistence of a TR-containing plasmid. Depletion of NAP1L1 led to a reduced nucleosome positioning on the viral genome. Furthermore, depletion of NAP1L1 increased the transcription of viral lytic genes and overexpression decreased the promoter activities of LANA-regulated genes. These results confirmed that LANA recruitment of NAP1L1 helps in assembling nucleosome for the chromatinization of newly synthesized viral DNA. PMID:27599637

  5. Nap it or leave it in the elderly: A nap after practice relaxes age-related limitations in procedural memory consolidation.

    PubMed

    Korman, M; Dagan, Y; Karni, A

    2015-10-01

    Using a training protocol that effectively induces procedural memory consolidation (PMC) in young adults, we show that older adults are good learners, robustly improving their motor performance during training. However, performance declined over the day, and overnight 'offline' consolidation phase performance gains were under-expressed. A post-training nap countered these deficits. PMC processes are preserved but under-engaged in the elderly; sleep can relax some of the age-related constraints on long-term plasticity. PMID:26348880

  6. Anthropometric and physical characteristics of english academy rugby league players.

    PubMed

    Till, Kevin; Tester, Emma; Jones, Ben; Emmonds, Stacey; Fahey, Jack; Cooke, Carlton

    2014-02-01

    The purpose of the present study was to evaluate the anthropometric and physical characteristics of English academy rugby league players by annual-age category (under 16s-under 20s) and between backs and forwards. Data were collected on 133 academy players over a 6-year period (resulting in a total of 257 assessments). Player assessments comprised of anthropometric (height, body mass, sum of 4 skinfolds) and physical (vertical jump, 10- and 20-m sprint, estimated V[Combining Dot Above]O2max via the yo-yo intermittent recovery test level 1, absolute 1 repetition maximum [1RM], and relative squat, bench press, and prone row) measures. Univariate analysis of variance demonstrated significant (p ≤ 0.05) increases in height, body mass, vertical jump, absolute, and relative strength measures across the 5 annual-age categories (e.g., body mass: under 16s = 75.2 ± 11.1, under 20s = 88.9 ± 8.5 kg; vertical jump: under 16s = 45.7 ± 5.2, under 20s = 52.8 ± 5.4 cm; 1RM bench press: under 16s = 73.9 ± 13.2, under 20s = 114.3 ± 15.3 kg). Independent t-tests identified significant (p ≤ 0.05) differences between backs and forwards for anthropometric (e.g., under 16s body mass: backs = 68.4 ± 8.6, forwards = 80.9 ± 9.7 kg) and physical (e.g., under 19s 20-m sprint: backs = 3.04 ± 0.08, forwards = 3.14 ± 0.12s; under 18s relative squat: backs = 1.65 ± 0.18, forwards = 1.51 ± 0.17 kg·kg) characteristics that were dependent on the age category and measure assessed. Findings highlight that anthropometric and physical characteristics develop across annual-age categories and between backs and forwards in academy rugby league players. These findings provide comparative data for such populations and support the need to monitor player development in junior rugby league players.

  7. A NAP-AAO3 Regulatory Module Promotes Chlorophyll Degradation via ABA Biosynthesis in Arabidopsis Leaves[W][OPEN

    PubMed Central

    Yang, Jiading; Worley, Eric

    2014-01-01

    Chlorophyll degradation is an important part of leaf senescence, but the underlying regulatory mechanisms are largely unknown. Excised leaves of an Arabidopsis thaliana NAC-LIKE, ACTIVATED BY AP3/PI (NAP) transcription factor mutant (nap) exhibited lower transcript levels of known chlorophyll degradation genes, STAY-GREEN1 (SGR1), NON-YELLOW COLORING1 (NYC1), PHEOPHYTINASE (PPH), and PHEIDE a OXYGENASE (PaO), and higher chlorophyll retention than the wild type during dark-induced senescence. Transcriptome coexpression analysis revealed that abscisic acid (ABA) metabolism/signaling genes were disproportionately represented among those positively correlated with NAP expression. ABA levels were abnormally low in nap leaves during extended darkness. The ABA biosynthetic genes 9-CIS-EPOXYCAROTENOID DIOXYGENASE2, ABA DEFICIENT3, and ABSCISIC ALDEHYDE OXIDASE3 (AAO3) exhibited abnormally low transcript levels in dark-treated nap leaves. NAP transactivated the promoter of AAO3 in mesophyll cell protoplasts, and electrophoretic mobility shift assays showed that NAP can bind directly to a segment (−196 to −162 relative to the ATG start codon) of the AAO3 promoter. Exogenous application of ABA increased the transcript levels of SGR1, NYC1, PPH, and PaO and suppressed the stay-green phenotype of nap leaves during extended darkness. Overexpression of AAO3 in nap leaves also suppressed the stay-green phenotype under extended darkness. Collectively, the results show that NAP promotes chlorophyll degradation by enhancing transcription of AAO3, which leads to increased levels of the senescence-inducing hormone ABA. PMID:25516602

  8. Ramelteon Prior to a Short Evening Nap Impairs Neurobehavioral Performance for up to 12 Hours after Awakening

    PubMed Central

    Cohen, Daniel A.; Wang, Wei; Klerman, Elizabeth B.; Rajaratnam, Shantha M.W.

    2010-01-01

    Study Objectives: Planned naps can improve performance when the habitual or nocturnal sleep schedule is disrupted. It may be difficult, however, to achieve sleep during a nap, particularly during the circadian peak in alertness in the early evening. Prior studies with the melatonin agonist, ramelteon, reported that this hypnotic does not impair neurobehavioral performance. We tested whether ramelteon could improve nap efficiency in the early evening and subsequent performance during a simulated 8-h night shift. Methods: 10 healthy volunteers aged 19-31 years participated in an inpatient randomized, double-blind, placebo-controlled crossover study. Ramelteon 8 mg or placebo was administered 30 min prior to a 2-h nap opportunity commencing 13 h after each individual's habitual morning wake time. Results: Ramelteon did not significantly affect sleep efficiency during the nap prior to the night shift. Following the nap, ramelteon was associated with significantly worse neurobehavioral performance on assessments immediately following the nap and during the simulated night shift. Conclusions: Although ramelteon did not significantly affect sleep during the nap, it was associated with significant impairments in neurobehavioral performance for up to 12 h after administration. High homeostatic sleep pressure combined with the circadian performance nadir may increase the vulnerability to hypnotic-induced neurobehavioral impairments. The findings do not support the use of ramelteon prior to an evening prophylactic nap, as there may be residual effects that last for several hours. Furthermore, this study highlights the pitfalls of applying side-effect profiles obtained in one context to another. Citation: Cohen DA; Wang W; Klerman EB; Rajaratnam SMW. Ramelteon prior to a short evening nap impairs neurobehavioral performance for up to 12 hours after awakening. J Clin Sleep Med 2010;6(6):565-571. PMID:21206545

  9. Centlein mediates an interaction between C-Nap1 and Cep68 to maintain centrosome cohesion.

    PubMed

    Fang, Guoliang; Zhang, Dachuan; Yin, Huilong; Zheng, Lu; Bi, Xiaolin; Yuan, Li

    2014-04-15

    Centrosome cohesion, mostly regarded as a proteinaceous linker between parental centrioles, ensures that the interphase centrosome(s) function as a single microtubule-organizing center. Impairment of centrosome cohesion leads to the splitting of centrosomes. Although the list of cohesion proteins is growing, the precise composition and regulation of centrosome cohesion are still largely unknown. In this study, we show that the centriolar protein centlein (also known as CNTLN) localizes to the proximal ends of the centrioles and directly interacts with both C-Nap1 (also known as Cep250) and Cep68. Moreover, centlein complexes with C-Nap1 and Cep68 at the proximal ends of centrioles during interphase and functions as a molecular link between C-Nap1 and Cep68. Depletion of centlein impairs recruitment of Cep68 to the centrosomes and, in turn, results in centrosome splitting. Both centlein and Cep68 are novel Nek2A substrates. Collectively, our data demonstrate that centrosome cohesion is maintained by the newly identified complex of C-Nap1-centlein-Cep68. PMID:24554434

  10. NAP-1, Nucleosome assembly protein 1, a histone chaperone involved in Drosophila telomeres.

    PubMed

    López-Panadès, Elisenda; Casacuberta, Elena

    2016-03-01

    Telomere elongation is a function that all eukaryote cells must accomplish in order to guarantee, first, the stability of the end of the chromosomes and second, to protect the genetic information from the inevitable terminal erosion. The targeted transposition of the telomere transposons HeT-A, TART and TAHRE perform this function in Drosophila, while the telomerase mechanism elongates the telomeres in most eukaryotes. In order to integrate telomere maintenance together with cell cycle and metabolism, different components of the cell interact, regulate, and control the proteins involved in telomere elongation. Different partners of the telomerase mechanism have already been described, but in contrast, very few proteins have been related with assisting the telomere transposons of Drosophila. Here, we describe for the first time, the implication of NAP-1 (Nucleosome assembly protein 1), a histone chaperone that has been involved in nuclear transport, transcription regulation, and chromatin remodeling, in telomere biology. We find that Nap-1 and HeT-A Gag, one of the major components of the Drosophila telomeres, are part of the same protein complex. We also demonstrate that their close interaction is necessary to guarantee telomere stability in dividing cells. We further show that NAP-1 regulates the transcription of the HeT-A retrotransposon, pointing to a positive regulatory role of NAP-1 in telomere expression. All these results facilitate the understanding of the transposon telomere maintenance mechanism, as well as the integration of telomere biology with the rest of the cell metabolism.

  11. Deep-sea hydrothermal vent Epsilonproteobacteria encode a conserved and widespread nitrate reduction pathway (Nap)

    PubMed Central

    Vetriani, Costantino; Voordeckers, James W; Crespo-Medina, Melitza; O'Brien, Charles E; Giovannelli, Donato; Lutz, Richard A

    2014-01-01

    Despite the frequent isolation of nitrate-respiring Epsilonproteobacteria from deep-sea hydrothermal vents, the genes coding for the nitrate reduction pathway in these organisms have not been investigated in depth. In this study we have shown that the gene cluster coding for the periplasmic nitrate reductase complex (nap) is highly conserved in chemolithoautotrophic, nitrate-reducing Epsilonproteobacteria from deep-sea hydrothermal vents. Furthermore, we have shown that the napA gene is expressed in pure cultures of vent Epsilonproteobacteria and it is highly conserved in microbial communities collected from deep-sea vents characterized by different temperature and redox regimes. The diversity of nitrate-reducing Epsilonproteobacteria was found to be higher in moderate temperature, diffuse flow vents than in high temperature black smokers or in low temperatures, substrate-associated communities. As NapA has a high affinity for nitrate compared with the membrane-bound enzyme, its occurrence in vent Epsilonproteobacteria may represent an adaptation of these organisms to the low nitrate concentrations typically found in vent fluids. Taken together, our findings indicate that nitrate reduction is widespread in vent Epsilonproteobacteria and provide insight on alternative energy metabolism in vent microorganisms. The occurrence of the nap cluster in vent, commensal and pathogenic Epsilonproteobacteria suggests that the ability of these bacteria to respire nitrate is important in habitats as different as the deep-sea vents and the human body. PMID:24430487

  12. Deep-sea hydrothermal vent Epsilonproteobacteria encode a conserved and widespread nitrate reduction pathway (Nap).

    PubMed

    Vetriani, Costantino; Voordeckers, James W; Crespo-Medina, Melitza; O'Brien, Charles E; Giovannelli, Donato; Lutz, Richard A

    2014-07-01

    Despite the frequent isolation of nitrate-respiring Epsilonproteobacteria from deep-sea hydrothermal vents, the genes coding for the nitrate reduction pathway in these organisms have not been investigated in depth. In this study we have shown that the gene cluster coding for the periplasmic nitrate reductase complex (nap) is highly conserved in chemolithoautotrophic, nitrate-reducing Epsilonproteobacteria from deep-sea hydrothermal vents. Furthermore, we have shown that the napA gene is expressed in pure cultures of vent Epsilonproteobacteria and it is highly conserved in microbial communities collected from deep-sea vents characterized by different temperature and redox regimes. The diversity of nitrate-reducing Epsilonproteobacteria was found to be higher in moderate temperature, diffuse flow vents than in high temperature black smokers or in low temperatures, substrate-associated communities. As NapA has a high affinity for nitrate compared with the membrane-bound enzyme, its occurrence in vent Epsilonproteobacteria may represent an adaptation of these organisms to the low nitrate concentrations typically found in vent fluids. Taken together, our findings indicate that nitrate reduction is widespread in vent Epsilonproteobacteria and provide insight on alternative energy metabolism in vent microorganisms. The occurrence of the nap cluster in vent, commensal and pathogenic Epsilonproteobacteria suggests that the ability of these bacteria to respire nitrate is important in habitats as different as the deep-sea vents and the human body.

  13. Physical Fitness of Police Academy Cadets: Baseline Characteristics and Changes During a 16-Week Academy.

    PubMed

    Crawley, Amy A; Sherman, Ross A; Crawley, William R; Cosio-Lima, Ludmila M

    2016-05-01

    Police academies traditionally emphasize the importance of being physically fit. The purpose of this research was to determine cadet baseline physical fitness characteristics and assess effectiveness of a 16-week training program. Sixty-eight cadets (61 men, 7 women) volunteered to have baseline physical fitness characteristics assessed, and 55 cadets (49 men, 6 women) completed further testing at weeks 8 and 16. The testing comprised hand grip (strength), arm crank (upper-body power), 30 seconds Wingate (lower body power), sum of skinfolds and percentage body fat (body composition), 40-yard dash (sprint speed), 1 repetition maximum bench press (strength), T-test (agility), and sit-and-reach (flexibility). In addition, cadets completed standardized state testing (push-ups, sit-ups, vertical jump, and half-mile shuttle run). The training program consisted of 1 hour sessions, 3 d·wk, including aerobic, plyometrics, body weight, and resistance exercise. Significant changes were found in agility (p < 0.01), upper-body and lower-body peak power (p ≤ 0.05), sit-ups (p < 0.01), push-ups (p ≤ 0.05) across the first 8 weeks, and in agility (p ≤ 0.05), lower-body peak power (p ≤ 0.05), sit-ups (p < 0.01), push-ups (p ≤ 0.05), half-mile shuttle run (p < 0.01) across the full 16 weeks. However, none of the variables showed significant change across the second half of the program (weeks 8-16). A number of individual parameters of physical fitness showed evidence of improvement in the first 8 weeks, whereas none of the variables showed significant improvement in the second 8 weeks. This suggests modifications could be made to increase overall effectiveness of cadet physical training specifically after the 8-week mark. PMID:26466133

  14. Einstein Session of the Pontifical Academy.

    ERIC Educational Resources Information Center

    Science, 1980

    1980-01-01

    The texts of four speeches, given at the 1979 Einstein Session of the Pontifical Academy held in Rome, are presented. Each address relates to some aspect of the life and times of Albert Einstein. (SA)

  15. Control of periplasmic nitrate reductase gene expression (napEDABC) from Paracoccus pantotrophus in response to oxygen and carbon substrates.

    PubMed

    Sears, H J; Sawers, G; Berks, B C; Ferguson, S J; Richardson, D J

    2000-11-01

    The napEDABC operon of Paracoccus pantotrophus encodes a periplasmic nitrate reductase (NAP), together with electron-transfer components and proteins required for the synthesis of a fully functional enzyme. Previously, it had been shown that high NAP activity was observed when P. pantotrophus was grown aerobically on highly reduced carbon sources such as butyrate or caproate, but not when cultured on more oxidized substrates such as succinate or malate. The enzyme is not present to any extent when the organism is grown anaerobically under denitrifying conditions, regardless of the carbon source. Transcriptional analyses of the nap operon have now identified two initiation sites which were differentially regulated in response to the carbon source, with expression being maximal when cells were grown aerobically with butyrate. Analysis of a P. pantotrophus mutant (M6) deregulated for NAP activity identified a single C-->A transversion in a heptameric inverted-repeat sequence that partially overlapped the proximal promoter. Transcription analysis of this mutant revealed that expression of nap was completely derepressed under all growth conditions examined. Taken together, these findings indicate that nap transcription is negatively regulated during anaerobiosis, such that expression is restricted to aerobic growth, but only when the carbon source is highly reduced. PMID:11065376

  16. Napping in older people 'at risk' of dementia: relationships with depression, cognition, medical burden and sleep quality.

    PubMed

    Cross, Nathan; Terpening, Zoe; Rogers, Naomi L; Duffy, Shantel L; Hickie, Ian B; Lewis, Simon J G; Naismith, Sharon L

    2015-10-01

    Sleep disturbance is prevalent in older adults, particularly so in those at a greater risk of dementia. However, so far the clinical, medical and neuropsychological correlates of daytime sleep have not been examined. The aims of this study were to investigate the characteristics and effects of napping using actigraphy in older people, particularly in those 'at risk' of dementia. The study used actigraphy and sleep diaries to measure napping habits in 133 older adults 'at risk' of dementia (mean age = 65.5 years, SD = 8.4 years), who also underwent comprehensive medical, psychiatric and neuropsychological assessment. When defined by actigraphy, napping was present in 83.5% (111/133) of participants; however, duration and timing varied significantly among subjects. Nappers had significantly greater medical burden and body mass index, and higher rates of mild cognitive impairment. Longer and more frequent naps were associated with poorer cognitive functioning, as well as higher levels of depressive symptoms, while the timing of naps was associated with poorer nocturnal sleep quality (i.e. sleep latency and wake after sleep onset). This study highlights that in older adults 'at risk' of dementia, napping is associated with underlying neurobiological changes such as depression and cognition. Napping characteristics should be more routinely monitored in older individuals to elucidate their relationship with psychological and cognitive outcomes.

  17. Cloning and characterization of Arabidopsis thaliana AtNAP57--a homologue of yeast pseudouridine synthase Cbf5p.

    PubMed

    Maceluch, J; Kmieciak, M; Szweykowska-Kulińska, Z; Jarmołowski, A

    2001-01-01

    Rat Nap57 and its yeast homologue Cbf5p are pseudouridine synthases involved in rRNA biogenesis, localized in the nucleolus. These proteins, together with H/ACA class of snoRNAs compose snoRNP particles, in which snoRNA guides the synthase to direct site-specific pseudouridylation of rRNA. In this paper we present an Arabidopsis thaliana protein that is highly homologous to Cbf5p (72% identity and 85% homology) and NAP57 (67% identity and 81% homology). Moreover, the plant protein has conserved structural motifs that are characteristic features of pseudouridine synthases of the TruB class. We have named the cloned and characterized protein AtNAP57 (Arabidopsis thaliana homologue of NAP57). AtNAP57 is a 565 amino-acid protein and its calculated molecular mass is 63 kDa. The protein is encoded by a single copy gene located on chromosome 3 of the A. thaliana genome. Interestingly, the AtNAP57 gene does not contain any introns. Mutations in the human DKC1 gene encoding dyskerin (human homologue of yeast Cbf5p and rat NAP57) cause dyskeratosis congenita a rare inherited bone marrow failure syndrome characterized by abnormal skin pigmentation, nail dystrophy and mucosal leukoplakia.

  18. The Bulgarian Academy of Sciences in Transition from Learned Society to Totalitarian Academy (1944 1949)

    NASA Astrophysics Data System (ADS)

    Vavrek, Alexander

    The process of transforming the Bulgarian Academy of Sciences and Arts, founded in 1869 as a Bulgarian Learned Society, into a national research center began in 1940 and was significantly accelerated in 1944, immediately after the coup d''état of September 9, 1944, called during the last 50 years a ''socialist revolution''. Strong pressure was exerted on the Bulgarian ''bourgeois intelligentsia'' by the new Fatherland Front ruling circles controlled by the communists. Closing down of the old and appointing a new ''progressive'' Academy was also discussed. The urgent actions of the Executive Council of the Academy prevented these plans. A number of progressive-minded scholars and artists were elected to the Bulgarian Academy of Sciences and Arts in January 1945 and July 1946, and a plan for reorganizing the Academy was approved in November 1945. This opening stage of self-restructuring of the Academy was crossed out by the Law of the Bulgarian Academy of Sciences of 1947. By this law the Academy was transformed into a governmental organization, but some academic autonomy and respect for the academic traditions were preserved. Only two and a half years later, however, when the Bulgarian Communist Party had an absolute majority in the Parliament and the ''open building of socialism in the People''s Republic of Bulgaria'' had been already announced, a new, completely totalitarian, Law on the Bulgarian Academy of Sciences was passed.

  19. 32 CFR 575.6 - Catalogue, United States Military Academy.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 3 2014-07-01 2014-07-01 false Catalogue, United States Military Academy. 575.6... ADMISSION TO THE UNITED STATES MILITARY ACADEMY § 575.6 Catalogue, United States Military Academy. The latest edition of the catalogue, United States Military Academy, contains additional...

  20. 32 CFR 575.6 - Catalogue, United States Military Academy.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 3 2013-07-01 2013-07-01 false Catalogue, United States Military Academy. 575.6... ADMISSION TO THE UNITED STATES MILITARY ACADEMY § 575.6 Catalogue, United States Military Academy. The latest edition of the catalogue, United States Military Academy, contains additional...

  1. 32 CFR 575.6 - Catalogue, United States Military Academy.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 3 2011-07-01 2009-07-01 true Catalogue, United States Military Academy. 575.6... ADMISSION TO THE UNITED STATES MILITARY ACADEMY § 575.6 Catalogue, United States Military Academy. The latest edition of the catalogue, United States Military Academy, contains additional...

  2. 32 CFR 575.6 - Catalogue, United States Military Academy.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 3 2012-07-01 2009-07-01 true Catalogue, United States Military Academy. 575.6... ADMISSION TO THE UNITED STATES MILITARY ACADEMY § 575.6 Catalogue, United States Military Academy. The latest edition of the catalogue, United States Military Academy, contains additional...

  3. 32 CFR 575.6 - Catalogue, United States Military Academy.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 3 2010-07-01 2010-07-01 true Catalogue, United States Military Academy. 575.6... ADMISSION TO THE UNITED STATES MILITARY ACADEMY § 575.6 Catalogue, United States Military Academy. The latest edition of the catalogue, United States Military Academy, contains additional...

  4. The Arecibo Observatory Space Academy

    NASA Astrophysics Data System (ADS)

    Rodriguez-Ford, Linda A.; Fernanda Zambrano Marin, Luisa; Aponte Hernandez, Betzaida; Soto, Sujeily; Rivera-Valentin, Edgard G.

    2016-10-01

    The Arecibo Observatory Space Academy (AOSA) is an intense fifteen-week pre-college research program for qualified high school students residing in Puerto Rico, which includes ten days for hands-on, on site research activities. Our mission is to prepare students for their professional careers by allowing them to receive an independent and collaborative research experience on topics related to the multidisciplinary field of space science. Our objectives are to (1) supplement the student's STEM education via inquiry-based learning and indirect teaching methods, (2) immerse students in an ESL environment, further developing their verbal and written presentation skills, and (3) foster in every student an interest in the STEM fields by harnessing their natural curiosity and knowledge in order to further develop their critical thinking and investigation skills. Students interested in participating in the program go through an application, interview and trial period before being offered admission. They are welcomed as candidates the first weeks, and later become cadets while experiencing designing, proposing, and conducting research projects focusing in fields like Physics, Astronomy, Geology, Chemistry, and Engineering. Each individual is evaluated with program compatibility based on peer interaction, preparation, participation, and contribution to class, group dynamics, attitude, challenges, and inquiry. This helps to ensure that specialized attention can be given to students who demonstrate a dedication and desire to learn. Deciding how to proceed in the face of setbacks and unexpected problems is central to the learning experience. At the end of the semester, students present their research to the program mentors, peers, and scientific staff. This year, AOSA students also focused on science communication and were trained by NASA's FameLab. Students additionally presented their research at this year's International Space Development Conference (ISDC), which was held in

  5. National Academies-Review of the Research Program of the FreedomCAR and Fuel Partnership. Third Report

    SciTech Connect

    none,

    2011-06-09

    This report by the National Research Council's (NRC's) Committee on Review of the FreedomCAR and Fuel Research Program, Phase 3, is the third NRC review. The Phase 1 and Phase 2 reviews were issued in 2005 and 2008, respectively (NRC, 2005, 2008). The long-range goals of the Partnership focus on a transition to a highway transportation system that uses sustainable energy resources and reduces emissions, including net carbon emissions, on a life-cycle or well (source)-to-wheels basis (DOE, 2004). The Partnership focuses on precompetitive research and development (R&D) that can help to accelerate the emergence of technologies that can meet the long-range goals. • This review document is published by National Academies Press. You may (a) read the text for free on the National Academies Press web site, (b) download a free PDF after providing some identifying information, or (c) purchase a paperback copy of the book.

  6. CIDER PRESS, LOOKING SOUTHEAST ACROSS THE SCHUYLKILL RIVER. THIS PRESS, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    CIDER PRESS, LOOKING SOUTHEAST ACROSS THE SCHUYLKILL RIVER. THIS PRESS, CARVED OUT OF A LARGE BOULDER AT THE RIVERS EDGE, PROBABLY DATES FROM THE LIFETIME OF JOHN BARTRAM, IF NOT TO THE SWEDISH SETTLERS BEFORE HIM. THE IRON FENCE IS A NINETEENTH-CENTURY ADDITION - John Bartram House & Garden, 54th Street & Lindbergh Boulevard, Philadelphia, Philadelphia County, PA

  7. PRESS SHOP. SEVEN BLISS PRESSES STAMP OUT A VARIETY OF ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    PRESS SHOP. SEVEN BLISS PRESSES STAMP OUT A VARIETY OF CARTRIDGE AND SHELL CASINGS. THIS DEPARTMENT WAS TRANSFORMED FROM A MONEY-LOSING OPERATION TO A PROFIT CENTER UNDER THE FIRST WORKER-MANAGED QUALITY CIRCLE IN THE PLANT. - American Brass Foundry, 70 Sayre Street, Buffalo, Erie County, NY

  8. 75 FR 52318 - Presidential Academies for American History and Civics Education; Congressional Academies for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-25

    ... Presidential Academies for American History and Civics Education; Congressional Academies for Students of American History and Civics Education AGENCY: Office of Innovation and Improvement, Department of Education... American History and Civics Education, and 34 CFR 75.261(c)(2), as it applies to the project funded...

  9. High School Teaching Career Academies: Profiles and Practices. Urban Teacher Academy Project.

    ERIC Educational Resources Information Center

    Council of the Great City Schools, Washington, DC.

    The Urban Teacher Academy Project (UTAP) promotes the recruitment and preparation of qualified and diverse teachers for urban schools by expanding a school-to-career approach through high school teaching career academies. The UTAP has documented the best practices and developed practical information to guide the formation of career teaching…

  10. Pediatric automotive restraints, pediatricians, and the academy.

    PubMed

    Lieberman, H M; Emmet, W L; Coulson, A H

    1976-09-01

    Over 70% of the 192 Southern California Academy pediatricians responding to a survey teach parents about pediatric automotive safety devices but less than 3% do so on every visit. To test two methods of increasing the frequency of teaching, these pediatricians were randomly assigned to either a mailing from the Academy's local chapter (mail group) or a brief presentation by a local pharmaceutical representative at his regular visit (interview group); a follow-up was conducted one month later by mail. Sixty-one percent of the mail group and 49% of the interview group claimed that their teaching on this subject had increased since the original contact. While this difference did not reach statistical significance, it was in the same direction as the preferences for sources of pediatric information expressed by both groups of pediatricians. A special letter from the Academy was ranked most effective and a visit from the pharmaceutical representative was judged least effective. Because of the magnitude of the problem, availability of a solution, proof that pediatricians can influence health behavior related to children and acknowledgment of the Academy's role in pediatric education, an appeal is made for an all-out campaign by the Academy and its members to promote use of appropriate pediatric automotive safety devices.

  11. [Peculiarities of medical backup of low flight course and nap-of-the-earth].

    PubMed

    blaginin, A A; Lizogub, I N; Sinel'niov, S N; Zhil'tsova, I I

    2014-07-01

    Authors presented peculiarities of low flight course and nap-of-the-earth: quick change of orientation cues, ground proximity, possible bird collision, loss of radio signal, exposure of oscillating acceleration, caused by increased atmosphere turbulence. It is showed that low flight course and nap-of-the-earth require special health status of pilots, who must be ready to evaluate obstacle distance, obstacle position relative to aircraft plane, gain in altitude, flight elevation and closing speed, new obstacles and make a decision to fly-by or turn. These circumstances cause emotional tension that affects working capacity and professional reliance. Air medical officer should take additional measures for medical backup of these flight courses.

  12. NAP SACC: Implementation of an Obesity Prevention Intervention in an American Indian Head Start Program.

    PubMed

    Mattingly, Julie A; Andresen, Pamela A

    2016-01-01

    Low-income American Indian preschoolers are at greatest risk for overweight and obesity among children aged 2-5 years. The Nutrition and Physical Activity Self-Assessment for Child Care (NAP SACC) program is an evidence-based intervention that promotes healthy weight development for children enrolled in child care centers. The goal of this continuous quality improvement program is for the child care staff to establish environmental policies and practices that positively influence nutrition and physical activity-related behaviors. A community needs assessment of a Head Start program on an American Indian reservation identified obesity as a priority issue. This project implemented NAP SACC at 15 Head Start sites on the reservation. PMID:27383778

  13. NAP-2 Secreted by Human NK Cells Can Stimulate Mesenchymal Stem/Stromal Cell Recruitment

    PubMed Central

    Almeida, Catarina R.; Caires, Hugo R.; Vasconcelos, Daniela P.; Barbosa, Mário A.

    2016-01-01

    Summary Strategies for improved homing of mesenchymal stem cells (MSCs) to a place of injury are being sought and it has been shown that natural killer (NK) cells can stimulate MSC recruitment. Here, we studied the chemokines behind this recruitment. Assays were performed with bone marrow human MSCs and NK cells freshly isolated from healthy donor buffy coats. Supernatants from MSC-NK cell co-cultures can induce MSC recruitment but not to the same extent as when NK cells are present. Antibody arrays and ELISA assays confirmed that NK cells secrete RANTES (CCL5) and revealed that human NK cells secrete NAP-2 (CXCL7), a chemokine that can induce MSC migration. Inhibition with specific antagonists of CXCR2, a receptor that recognizes NAP-2, abolished NK cell-mediated MSC recruitment. This capacity of NK cells to produce chemokines that stimulate MSC recruitment points toward a role for this immune cell population in regulating tissue repair/regeneration. PMID:27052313

  14. PR and the Student Press.

    ERIC Educational Resources Information Center

    Holland, Sandy

    1994-01-01

    Techniques for college public relations professionals to use in promoting a cooperative relationship with the student press are outlined. These include being available to students, having regular meetings, providing access to administrators, providing information that creates context for news, and releasing news directly to the student press. (MSE)

  15. Press, Politics and Popular Government.

    ERIC Educational Resources Information Center

    Will, George F., Ed.

    A panel discussion on politics and the press was held at the convention of the American Political Science Association in September 1971. This volume contains an essay delivered at that panel on the various functions or activities of the press--adversary, surrogate, sovereign--and remarks of the three discussants. In addition, an essay especially…

  16. The CIA and the Press.

    ERIC Educational Resources Information Center

    Carvalho, Bernardo A.

    The involvement of the Central Intelligence Agency (CIA) with both United States and foreign news media has been recorded in numerous publications. This report reviews the important aspects of the CIA-press relationships as they have appeared in print and discusses the implications of these relationsihps for the credibility of the press. Media…

  17. Erotic subset for the Nencki Affective Picture System (NAPS ERO): cross-sexual comparison study

    PubMed Central

    Wierzba, Małgorzata; Riegel, Monika; Pucz, Anna; Leśniewska, Zuzanna; Dragan, Wojciech Ł.; Gola, Mateusz; Jednoróg, Katarzyna; Marchewka, Artur

    2015-01-01

    Research on the processing of sexual stimuli has proved that such material has high priority in human cognition. Yet, although sex differences in response to sexual stimuli were extensively discussed in the literature, sexual orientation was given relatively little consideration, and material suitable for relevant research is difficult to come by. With this in mind, we present a collection of 200 erotic images, accompanied by their self-report ratings of emotional valence and arousal by homo- and heterosexual males and females (n = 80, divided into four equal-sized subsamples). The collection complements the Nencki Affective Picture System (NAPS) and is intended to be used as stimulus material in experimental research. The erotic images are divided into five categories, depending on their content: opposite-sex couple (50), male couple (50), female couple (50), male (25) and female (25). Additional 100 control images from the NAPS depicting people in a non-erotic context were also used in the study. We showed that recipient sex and sexual orientation strongly influenced the evaluation of erotic content. Thus, comparisons of valence and arousal ratings in different subject groups will help researchers select stimuli set for the purpose of various experimental designs. To facilitate the use of the dataset, we provide an on-line tool, which allows the user to browse the images interactively and select proper stimuli on the basis of several parameters. The NAPS ERO image collection together with the data are available to the scientific community for non-commercial use at http://naps.nencki.gov.pl. PMID:26441715

  18. Erotic subset for the Nencki Affective Picture System (NAPS ERO): cross-sexual comparison study.

    PubMed

    Wierzba, Małgorzata; Riegel, Monika; Pucz, Anna; Leśniewska, Zuzanna; Dragan, Wojciech Ł; Gola, Mateusz; Jednoróg, Katarzyna; Marchewka, Artur

    2015-01-01

    Research on the processing of sexual stimuli has proved that such material has high priority in human cognition. Yet, although sex differences in response to sexual stimuli were extensively discussed in the literature, sexual orientation was given relatively little consideration, and material suitable for relevant research is difficult to come by. With this in mind, we present a collection of 200 erotic images, accompanied by their self-report ratings of emotional valence and arousal by homo- and heterosexual males and females (n = 80, divided into four equal-sized subsamples). The collection complements the Nencki Affective Picture System (NAPS) and is intended to be used as stimulus material in experimental research. The erotic images are divided into five categories, depending on their content: opposite-sex couple (50), male couple (50), female couple (50), male (25) and female (25). Additional 100 control images from the NAPS depicting people in a non-erotic context were also used in the study. We showed that recipient sex and sexual orientation strongly influenced the evaluation of erotic content. Thus, comparisons of valence and arousal ratings in different subject groups will help researchers select stimuli set for the purpose of various experimental designs. To facilitate the use of the dataset, we provide an on-line tool, which allows the user to browse the images interactively and select proper stimuli on the basis of several parameters. The NAPS ERO image collection together with the data are available to the scientific community for non-commercial use at http://naps.nencki.gov.pl. PMID:26441715

  19. Modeling Napping, Post-Lunch Dip, and Other Variations in Human Sleep Propensity

    PubMed Central

    Bes, Frederik; Jobert, Marc; Schulz, Hartmut

    2009-01-01

    Study Objectives: To model sleep propensity (SP) as a continuous variable across 24 hours and to model the post-noon nap zone, or post-lunch dip in performance, and the early evening trough in SP. Methods: The present model is a variant of the 2-process model with 2 major modifications. (1) The circadian threshold process was replaced by sleep drive R, derived from REM sleep propensity, which shows a strong circadian modulation. (2) The model is based on a multiplicative interaction between the 2 input variables S and R. The model parameters S and R were estimated from experimental data. Thus, SP is modeled by multiplicative interaction of 2 sleep drives, S and R, the former of homeostatic, the latter of circadian nature. In short: SP = S × R. Results: Under the condition of normal phase and duration of nighttime sleep, SP across 24 hours displays 4 characteristics, (a) a major peak at nighttime, (b) a secondary increase, which peaks post-noon, (c) a first local minimum at sleep offset in the morning, and (d) a second local minimum in the early evening hours. Model simulations with either delayed or advanced sleep times suggest that the magnitude of the post-noon nap zone depends on the phase of the major sleep period within 24 hours. While the nap zone is attenuated or disappears when night sleep is delayed, SP increases during daytime when night sleep is advanced. In all conditions, the evening local minimum of SP remained stable. Conclusions: SP can be modeled as a continuous variable, based on the multiplicative interaction of 2 basic sleep drives. The model predictions are in agreement with known variations of SP across 24 hours. Citation: Bes F; Jobert M; Schulz H. Modeling napping, post-lunch dip, and other variations in human sleep propensity. SLEEP 2009;32(3):392-398. PMID:19294959

  20. The tumor suppressor proteins ASPP1 and ASPP2 interact with C-Nap1 and regulate centrosome linker reassembly.

    PubMed

    Zhang, Yuanyuan; Wang, Yuqi; Wei, Youheng; Ma, Jian; Peng, Jingtao; Wumaier, Reziya; Shen, Suqin; Zhang, Pingzhao; Yu, Long

    2015-03-13

    Centrosome linker tethers interphase centrosomes together allowing them to function as a single microtubule organization center. The centrosome linker is disrupted at the onset of mitosis to ensure timely centrosome disjunction and bipolar spindle formation and is reassembled at the end of mitosis. While the mechanism controlling centrosome linker disassembly at early mitosis has been well explored, little is known about how the linker is subsequently reassembled before mitotic exit. Here we report that ASPP1 and ASPP2, two members of the apoptosis stimulating proteins of p53 (ASPP) family, are involved in centrosome linker reassembly. We showed that ASPP1/2 interacted with centrosome linker protein C-Nap1. Co-depletion of ASPP1 and ASPP2 inhibited re-association of C-Nap1 with centrosome at the end of mitosis. Moreover, ASPP1/2 facilitated the interaction between C-Nap1 and PP1α, and this interaction was significantly reduced by co-depletion of ASPP1/2. ASPP1/2 antagonized the NEK2A-mediated C-Nap1 Ser2417/2421 phosphorylation in a PP1-dependent manner. Co-depletion of ASPP1 and ASPP2 inhibited dephosphorylation of C-Nap1 (Ser2417/2421) at the end of mitosis. Based on these findings, we propose that ASPP1/2 act as PP1-targeting subunits to facilitate C-Nap1 dephosphorylation and centrosome linker reassembly at the end of mitosis. PMID:25660448

  1. Removal of Ca2+ and Zn2+ from aqueous solutions by zeolites NaP and KP.

    PubMed

    Yusof, Alias Mohd; Malek, Nik Ahmad Nizam Nik; Kamaruzaman, Nurul Asyikin; Adil, Muhammad

    2010-01-01

    Zeolites P in sodium (NaP) and potassium (KP) forms were used as adsorbents for the removal of calcium (Ca2+) and zinc (Zn2+) cations from aqueous solutions. Zeolite KP was prepared by ion exchange of K+ with Na+ which neutralizes the negative charge of the zeolite P framework structure. The ion exchange capacity of K+ on zeolite NaP was determined through the Freundlich isotherm equilibrium study. Characterization of zeolite KP was determined using infrared spectroscopy and X-ray diffraction (XRD) techniques. From the characterization, the structure of zeolite KP was found to remain stable after the ion exchange process. Zeolites KP and NaP were used for the removal of Ca and Zn from solution. The amount of Ca2+ and Zn2+ in aqueous solution before and after the adsorption by zeolites was analysed using the flame atomic absorption spectroscopy method. The removal of Ca2+ and Zn2+ followed the Freundlich isotherm rather than the Langmuir isotherm model. This result also revealed that zeolite KP adsorbs Ca2+ and Zn2+ more than zeolite NaP and proved that modification of zeolite NaP with potassium leads to an increase in the adsorption efficiency of the zeolite. Therefore, the zeolites NaP and KP can be used for water softening (Ca removal) and reducing water pollution/toxicity (Zn removal). PMID:20232677

  2. Effects of Napping on Sleepiness and Sleep-Related Performance Deficits in Night-Shift Workers: A Systematic Review

    PubMed Central

    Ruggiero, Jeanne S.; Redeker, Nancy S.

    2014-01-01

    Night-shift workers are prone to sleep deprivation, misalignment of circadian rhythms, and subsequent sleepiness and sleep-related performance deficits. The purpose of this narrative systematic review is to critically review and synthesize the scientific literature regarding improvements in sleepiness and sleep-related performance deficits following planned naps taken during work-shift hours by night workers and to recommend directions for future research and practice. We conducted a literature search using the Medline, PsychInfo, CINAHL, Cochrane Library, and Health and Safety Science Abstracts databases and included English-language quasi-experimental and experimental studies that evaluated the effects of a nighttime nap taken during a simulated or actual night-work shift. We identified 13 relevant studies, which consisted primarily of small samples and mixed designs. Most investigators found that, despite short periods of sleep inertia immediately following naps, night-shift napping led to decreased sleepiness and improved sleep-related performance. None of the studies examined the effects of naps on safety outcomes in the workplace. Larger-scale randomized clinical trials of night-shift napping and direct safety outcomes are needed prior to wider implementation. PMID:23411360

  3. Cellular expression and localization of DGKζ-interacting NAP1-like proteins in the brain and functional implications under hypoxic stress.

    PubMed

    Takahashi, Nobuya; Hozumi, Yasukazu; Tanaka, Toshiaki; Okada, Masashi; Iseki, Ken; Hayasaka, Kiyoshi; Goto, Kaoru

    2014-11-01

    Diacylglycerol kinase (DGK) catalyzes conversion of a lipid second messenger diacylglycerol to another messenger molecule phosphatidic acid. Consequently, DGK plays a pivotal role in cellular pathophysiology by regulating the levels of these two messengers. We reported previously that DGKζ translocates from the nucleus to cytoplasm in hippocampal neurons under ischemic/hypoxic stress. In addition, we also identified nucleosome assembly protein 1 (NAP1)-like proteins NAP1L1 and NAP1L4 as novel DGKζ-interacting partners using a proteomic approach and revealed that these NAP1-like proteins induce cytoplasmic translocation of DGKζ in overexpressed cells because NAP1-like proteins associate with the nuclear localization signal of DGKζ and block its nuclear import via importin α. In the present study, we examined whether NAP1-like proteins are expressed in the brain and whether the molecular interaction of DGKζ and NAP1-like proteins would be changed in the brain after hypoxic stress. Immunohistochemistry revealed that NAP1L1 and NAP1L4 are widely expressed in neurons and glial cells in the brain with some differences. After 3 days of transient whole-body hypoxic stress, DGKζ translocated from the nucleus to cytoplasm in hippocampal pyramidal neurons, whereas NAP1-like proteins remained in the cytoplasm. Contrary to our expectations, NAP1-like proteins showed no change in their expression levels. The molecular interaction between DGKζ and NAP1-like proteins was attenuated after hypoxic stress. These results suggest that DGKζ cytoplasmic translocation in neurons under hypoxic stress is regulated by some mechanism which differs from that mediated by NAP1-like proteins. PMID:24893663

  4. Protocadherin-18b interacts with Nap1 to control motor axon growth and arborization in zebrafish.

    PubMed

    Biswas, Sayantanee; Emond, Michelle R; Duy, Phan Q; Hao, Le T; Beattie, Christine E; Jontes, James D

    2014-03-01

    The proper assembly of neural circuits during development requires the precise control of axon outgrowth, guidance, and arborization. Although the protocadherin family of cell surface receptors is widely hypothesized to participate in neural circuit assembly, their specific roles in neuronal development remain largely unknown. Here we demonstrate that zebrafish pcdh18b is involved in regulating axon arborization in primary motoneurons. Although axon outgrowth and elongation appear normal, antisense morpholino knockdown of pcdh18b results in dose-dependent axon branching defects in caudal primary motoneurons. Cell transplantation experiments show that this effect is cell autonomous. Pcdh18b interacts with Nap1, a core component of the WAVE complex, through its intracellular domain, suggesting a role in the control of actin assembly. Like that of Pcdh18b, depletion of Nap1 results in reduced branching of motor axons. Time-lapse imaging and quantitative analysis of axon dynamics indicate that both Pcdh18b and Nap1 regulate axon arborization by affecting the density of filopodia along the shaft of the extending axon. PMID:24371087

  5. C-NAP1 and rootletin restrain DNA damage-induced centriole splitting and facilitate ciliogenesis.

    PubMed

    Conroy, Pauline C; Saladino, Chiara; Dantas, Tiago J; Lalor, Pierce; Dockery, Peter; Morrison, Ciaran G

    2012-10-15

    Cilia are found on most human cells and exist as motile cilia or non-motile primary cilia. Primary cilia play sensory roles in transducing various extracellular signals, and defective ciliary functions are involved in a wide range of human diseases. Centrosomes are the principal microtubule-organizing centers of animal cells and contain two centrioles. We observed that DNA damage causes centriole splitting in non-transformed human cells, with isolated centrioles carrying the mother centriole markers CEP170 and ninein but not kizuna or cenexin. Loss of centriole cohesion through siRNA depletion of C-NAP1 or rootletin increased radiation-induced centriole splitting, with C-NAP1-depleted isolated centrioles losing mother markers. As the mother centriole forms the basal body in primary cilia, we tested whether centriole splitting affected ciliogenesis. While irradiated cells formed apparently normal primary cilia, most cilia arose from centriolar clusters, not from isolated centrioles. Furthermore, C-NAP1 or rootletin knockdown reduced primary cilium formation. Therefore, the centriole cohesion apparatus at the proximal end of centrioles may provide a target that can affect primary cilium formation as part of the DNA damage response. PMID:23070519

  6. Napping to renew learning capacity: enhanced encoding after stimulation of sleep slow oscillations.

    PubMed

    Antonenko, Daria; Diekelmann, Susanne; Olsen, Cathrin; Born, Jan; Mölle, Matthias

    2013-04-01

    As well as consolidating memory, sleep has been proposed to serve a second important function for memory, i.e. to free capacities for the learning of new information during succeeding wakefulness. The slow wave activity (SWA) that is a hallmark of slow wave sleep could be involved in both functions. Here, we aimed to demonstrate a causative role for SWA in enhancing the capacity for encoding of information during subsequent wakefulness, using transcranial slow oscillation stimulation (tSOS) oscillating at 0.75 Hz to induce SWA in healthy humans during an afternoon nap. Encoding following the nap was tested for hippocampus-dependent declarative materials (pictures, word pairs, and word lists) and procedural skills (finger sequence tapping). As compared with a sham stimulation control condition, tSOS during the nap enhanced SWA and significantly improved subsequent encoding on all three declarative tasks (picture recognition, cued recall of word pairs, and free recall of word lists), whereas procedural finger sequence tapping skill was not affected. Our results indicate that sleep SWA enhances the capacity for encoding of declarative materials, possibly by down-scaling hippocampal synaptic networks that were potentiated towards saturation during the preceding period of wakefulness. PMID:23301831

  7. Redox metabolites signal polymicrobial biofilm development via the NapA oxidative stress cascade in Aspergillus

    PubMed Central

    Zheng, He; Kim, Jaekuk; Liew, Mathew; Yan, John K.; Herrera, Oscar; Bok, JinWoo; Kelleher, Neil L.; Keller, Nancy P.; Wang, Yun

    2014-01-01

    Summary Background Filamentous fungi and bacteria form mixed-species biofilms in nature and diverse clinical contexts. They secrete a wealth of redox-active small molecule secondary metabolites, which are traditionally viewed as toxins that inhibit growth of competing microbes. Results Here we report that these “toxins” can act as interspecies signals, affecting filamentous fungal development via oxidative stress regulation. Specifically, in co-culture biofilms, Pseudomonas aeruginosa phenazine-derived metabolites differentially modulated Aspergillus fumigatus development, shifting from weak vegetative growth to induced asexual sporulation (conidiation) along a decreasing phenazine gradient. The A. fumigatus morphological shift correlated with the production of phenazine radicals and concomitant reactive oxygen species (ROS) production generated by phenazine redox cycling. Phenazine conidiation signaling was conserved in the genetic model A. nidulans, and mediated by NapA, a homolog of AP-1-like bZIP transcription factor, which is essential for the response to oxidative stress in humans, yeast, and filamentous fungi. Expression profiling showed phenazine treatment induced a NapA-dependent response of the global oxidative stress metabolome including the thioredoxin, glutathione and NADPH-oxidase systems. Conidiation induction in A. nidulans by another microbial redox-active secondary metabolite, gliotoxin, also required NapA. Conclusions This work highlights that microbial redox metabolites are key signals for sporulation in filamentous fungi, which are communicated through an evolutionarily conserved eukaryotic stress response pathway. It provides a foundation for interspecies signaling in environmental and clinical biofilms involving bacteria and filamentous fungi. PMID:25532893

  8. Procedural performance following sleep deprivation remains impaired despite extended practice and an afternoon nap

    PubMed Central

    Kurniawan, Irma Triasih; Cousins, James Nicholas; Chong, Pearlynne L. H.; Chee, Michael W. L.

    2016-01-01

    The negative impact of sleep loss on procedural memory is well established, yet it remains unclear how extended practice opportunities or daytime naps can modulate the effect of a night of sleep deprivation. Here, participants underwent three training and test conditions on a sequential finger tapping task (SFTT) separated by at least one week. In the first condition they were trained in the evening followed by a night of sleep. Two further conditions took place where evening training was followed by a night of total sleep deprivation (TSD). One of the TSD conditions included a one-hour nap opportunity (15:00). Compared to the condition in which sleep was permitted, a night of TSD resulted in poorer performance across 4 practices the following day (10:00–19:00). The deleterious effect of a single night of TSD on procedural performance, was neither clearly alleviated by an afternoon nap nor by multiple practice opportunities. Interestingly, significant gains in performance were observed in all conditions after a one-week delay. Recovery sleep on subsequent nights thus appeared to nullify the effect of a single night of sleep deprivation, underscoring the importance of offline consolidation on the acquisition of procedural skill. PMID:27782172

  9. C-NAP1 and rootletin restrain DNA damage-induced centriole splitting and facilitate ciliogenesis.

    PubMed

    Conroy, Pauline C; Saladino, Chiara; Dantas, Tiago J; Lalor, Pierce; Dockery, Peter; Morrison, Ciaran G

    2012-10-15

    Cilia are found on most human cells and exist as motile cilia or non-motile primary cilia. Primary cilia play sensory roles in transducing various extracellular signals, and defective ciliary functions are involved in a wide range of human diseases. Centrosomes are the principal microtubule-organizing centers of animal cells and contain two centrioles. We observed that DNA damage causes centriole splitting in non-transformed human cells, with isolated centrioles carrying the mother centriole markers CEP170 and ninein but not kizuna or cenexin. Loss of centriole cohesion through siRNA depletion of C-NAP1 or rootletin increased radiation-induced centriole splitting, with C-NAP1-depleted isolated centrioles losing mother markers. As the mother centriole forms the basal body in primary cilia, we tested whether centriole splitting affected ciliogenesis. While irradiated cells formed apparently normal primary cilia, most cilia arose from centriolar clusters, not from isolated centrioles. Furthermore, C-NAP1 or rootletin knockdown reduced primary cilium formation. Therefore, the centriole cohesion apparatus at the proximal end of centrioles may provide a target that can affect primary cilium formation as part of the DNA damage response.

  10. The histone chaperone protein Nucleosome Assembly Protein-1 (hNAP-1) binds HIV-1 Tat and promotes viral transcription

    PubMed Central

    Vardabasso, Chiara; Manganaro, Lara; Lusic, Marina; Marcello, Alessandro; Giacca, Mauro

    2008-01-01

    Background Despite the large amount of data available on the molecular mechanisms that regulate HIV-1 transcription, crucial information is still lacking about the interplay between chromatin conformation and the events that regulate initiation and elongation of viral transcription. During transcriptional activation, histone acetyltransferases and ATP-dependent chromatin remodeling complexes cooperate with histone chaperones in altering chromatin structure. In particular, human Nucleosome Assembly Protein-1 (hNAP-1) is known to act as a histone chaperone that shuttles histones H2A/H2B into the nucleus, assembles nucleosomes and promotes chromatin fluidity, thereby affecting transcription of several cellular genes. Results Using a proteomic screening, we identified hNAP-1 as a novel cellular protein interacting with HIV-1 Tat. We observed that Tat specifically binds hNAP1, but not other members of the same family of factors. Binding between the two proteins required the integrity of the basic domain of Tat and of two separable domains of hNAP-1 (aa 162–290 and 290–391). Overexpression of hNAP-1 significantly enhanced Tat-mediated activation of the LTR. Conversely, silencing of the protein decreased viral promoter activity. To explore the effects of hNAP-1 on viral infection, a reporter HIV-1 virus was used to infect cells in which hNAP-1 had been either overexpressed or knocked-down. Consistent with the gene expression results, these two treatments were found to increase and inhibit viral infection, respectively. Finally, we also observed that the overexpression of p300, a known co-activator of both Tat and hNAP-1, enhanced hNAP-1-mediated transcriptional activation as well as its interaction with Tat. Conclusion Our study reveals that HIV-1 Tat binds the histone chaperone hNAP-1 both in vitro and in vivo and shows that this interaction participates in the regulation of Tat-mediated activation of viral gene expression. PMID:18226242

  11. A comparison of impulse drying to double felted pressing on pilot- scale shoe presses and roll presses

    SciTech Connect

    Orloff, D.I.

    1992-08-01

    Pilot-scale shoe press and roll press experiments have been conducted to compare impulse drying and double felted pressing. Both ceramic coated and Beloit Type C press rolls have been evaluated. The experiments show that impulse drying can provide significantly higher outgoing solids than double felled pressing at the same impulse. For example, at an impulse of 0.234 MPa seconds (34 psi seconds), sheets at an ingoing solids of 52% were impulse dried (using the Beloit Type C press roll) to 68% solids while optimized double felled pressing could only yield press dryness of, at most, 60%.

  12. Lost Leaders: Women in the Global Academy

    ERIC Educational Resources Information Center

    Morley, Louise

    2014-01-01

    Drawing on data gathered from British Council seminars in Hong Kong, Tokyo and Dubai on "Absent Talent: Women in Research and Academic Leadership" (2012-2013), this paper discusses academic women's experiences and explanations for women's under-representation as knowledge leaders and producers in the global academy.…

  13. Common Ground. Feminist Collaboration in the Academy.

    ERIC Educational Resources Information Center

    Peck, Elizabeth G., Ed.; Mink, JoAnna Stephens, Ed.

    The fifteen articles in this anthology examine the process of collaboration as it fits into questions of gender. Articles include: "Educate, Organize, and Agitate: A Historical Overview of Feminist Collaboration in Great Britain and America, 1640-1930" (Melodie Andrews); "Beyond Feminism: An Intercultural Challenge for Transforming the Academy"…

  14. Extreme School Makeover: Career Academy Edition

    ERIC Educational Resources Information Center

    Thurman, Susan

    2007-01-01

    In this article, the author, a health and physical education teacher at the Red Bank High School in Chattanooga, Tennessee, describes the process of a school "makeover." Having been informed by the school principal that the plan was to develop a career academy and have it in place for the next school year, the author was assigned a new title:…

  15. Broad Academy's Growing Reach Draws Scrutiny

    ERIC Educational Resources Information Center

    Samuels, Christina A.

    2011-01-01

    Billionaire businessman Eli Broad, one of the country's most active philanthropists, founded the "Broad Superintendents Academy" in 2002 with an extraordinarily optimistic goal: Find leaders from both inside and outside education, train them, and have them occupying the superintendencies in a third of the 75 largest school districts--all in just…

  16. Broad Academy's Growing Reach Draws Scrutiny

    ERIC Educational Resources Information Center

    Samuels, Christina A.

    2011-01-01

    Billionaire businessman Eli Broad, one of the country's most active philanthropists, founded the Broad Superintendents Academy in 2002 with an extraordinarily optimistic goal: Find leaders from both inside and outside education, train them, and have them occupying the superintendencies in a third of the 75 largest school districts--in just two…

  17. Lafayette Academy Charter School: Safe and Predictable

    ERIC Educational Resources Information Center

    Principal Leadership, 2012

    2012-01-01

    This article features Lafayette Academy Charter School in New Orleans, Louisiana, which was recognized by the state board of education as a "center of excellence" in 2010, and given an automatic renewal of its charter--the only school in the state to receive this honor. The school has demonstrated impressive progress: the 2007 test results showed…

  18. Academy of the Canyons Report, Fall 2002.

    ERIC Educational Resources Information Center

    Meuschke, Daylene M.; Gribbons, Barry C.

    This report analyzes the Academy of the Canyons (AOC) program at College of the Canyons (COC), California. AOC, a middle college high school, is a collaboration between the William S. Hart High School District and College of the Canyons. The program is designed to provide a supportive, flexible, and academically enriched environment for students…

  19. Freedoms and Perils: Academy Schools in England

    ERIC Educational Resources Information Center

    Heilbronn, Ruth

    2016-01-01

    Can Dewey's Moral Principles in Education throw light on a contemporary policy issue in education, namely the privatisation of education through the establishment of academy schools in England? The article first considers what the policy entails, in terms of its conception of education as a market commodity. The next section suggests an…

  20. District Liaison Involvement in Partnership Academies

    ERIC Educational Resources Information Center

    Gustafson, Debra M.; Kiltz, Nancy

    2016-01-01

    In this article, Gustafson and Kiltz reflect on why they got involved in the very first master's level Professional Administrative Leadership Academy developed at Kansas State University (KSU). The authors had the opportunity to observe school leaders and noted that the most effective leaders shared their power and knowledge freely with others.…

  1. Disappearing Acts: Resuscitative Reflections on the Academy

    ERIC Educational Resources Information Center

    Twomey, Sarah

    2005-01-01

    To resuscitate means to revive or make go on. This paper is an exploration of my first six months at a Canadian university as a doctoral student. Through a chronological narrative, I explore my experiences through the governing relations of the academy as a way to provoke dialogue about the role of feminist researcher in the institution. By…

  2. General Education at the Coast Guard Academy.

    ERIC Educational Resources Information Center

    Sanders, William A.

    In seeking the most effective presentation of the liberal arts in curricula such as the heavily technical and professional curricula at the U.S. Coast Guard Academy, which leave little room for general education, general education course design must capture the imagination of students and motivate them for continuing self-education. Development of…

  3. Learning To Lead: The Galileo Leadership Academy.

    ERIC Educational Resources Information Center

    Kloosterhouse, Vicki

    2003-01-01

    Describes Michigan's Galileo Leadership Academy, a collaboration between K-12 and community college educators that develops leadership skills. Explains that 11 organizations participate in the program, and every two years each organization chooses five to nine leaders (primarily classroom educators) to be part of a new cohort. Asserts that the…

  4. Mater Academy Charter Middle School: Consistent Expectations

    ERIC Educational Resources Information Center

    Principal Leadership, 2010

    2010-01-01

    Mater Academy Charter Middle/High School is located in what was once a big box store in a commercial and industrial area of Hialeah Gardens, FL. The same energy that transformed a vacant store into a thriving campus for a grades 6-12 school is apparent in every classroom. Even the mayor of Hialeah Gardens credits the school with helping to…

  5. Difference, Power and Women in the Academy.

    ERIC Educational Resources Information Center

    Raddon, Arwen

    2003-01-01

    Reviews two books, "Identity and Difference in Higher Education: Outsiders Within" (Pauline Anderson and Jenny Williams, Eds.) and "Gender, Teaching and Research in Higher Education: Challenges for the 21st Century" (Gillian Howie and Ashley Tauchert, Eds.). Both books explore a range of key issues faced by women in the academy and the role that…

  6. Jupiter Environmental Research & Field Studies Academy.

    ERIC Educational Resources Information Center

    Huttemeyer, Bob

    1996-01-01

    Describes the development and workings of the Jupiter Environmental Research and Field Studies Academy that focuses on enabling both teachers and students to participate in real-life learning experiences. Discusses qualifications for admittance, curriculum, location, ongoing projects, students, academics, preparation for life, problem solving, and…

  7. What Are Academies the Answer to?

    ERIC Educational Resources Information Center

    Gorard, Stephen

    2009-01-01

    This paper builds upon an earlier analysis presented in this journal. Using official figures for school compositions and for outcomes at KS4 from 1997 to 2007, this paper considers each of the annual cohorts of new Academies in England, from 2002 to 2006. It shows that their level of success in comparison to their predecessors, national averages,…

  8. 78 FR 33836 - CPSC Safety Academy

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-05

    ... From the Federal Register Online via the Government Publishing Office CONSUMER PRODUCT SAFETY COMMISSION CPSC Safety Academy AGENCY: Consumer Product Safety Commission. ACTION: Notice. SUMMARY: The Consumer Product Safety Commission (CPSC, Commission, or we) is announcing its intent to hold a...

  9. Audience Perceptions of the Academy Awards Telecast.

    ERIC Educational Resources Information Center

    Real, Michael R.; Hassett, Christopher A.

    Residents in a southern California city were surveyed by telephone about their attitudes toward the telecast of the motion picture "Academy Awards" presentations. Of the 141 respondents, 71 had not watched the telecast, 42 had watched some of the broadcast, and 28 had watched all of it. Less than one third of the survey questions were specifically…

  10. Action Learning Drives the Emerald Academy

    ERIC Educational Resources Information Center

    Nalborczyk, Sarah; Sandelands, Luke

    2012-01-01

    This account examines the action learning process adopted by Emerald Group Publishing Ltd., embedded in the organization through the in-company Emerald Academy. In case study format, the paper emphasizes that in order to align learning with organizational objectives joined up thinking and practice is needed beyond the learning and development…

  11. Capital Wisdom: Papers from the Principals Academy.

    ERIC Educational Resources Information Center

    Walsh, Anne, Ed.; Feistritzer, Patricia, Ed.

    During the 1991 National Catholic Principals Academy, 30 elementary school principals came together to sharpen their skills, to be exposed to new trends and ideas, and to be empowered as Catholic education administrators. This handbook is the result of sharing ideas and is a compilation of tried and true processes, "how to" advice, and practical…

  12. Secrets of the STEM X Academy

    ERIC Educational Resources Information Center

    Teaching Science, 2016

    2016-01-01

    Science teachers, whether in primary or secondary schools, are in the front line for creating a more scientifically literate community. This article describes the STEM X Academy, a program created with the following goals: (1) demystify Science, Technology, Engineering, and Mathematics (STEM); (2) help teachers transform their teaching with…

  13. Corporate Features and Faith-Based Academies

    ERIC Educational Resources Information Center

    Green, Elizabeth

    2009-01-01

    This article forms an introductory exploration into the relationship between corporate features and religious values in Academies sponsored by a Christian foundation. This is a theme which arose from research comprising the ethnography of a City Technology College (CTC) with a Christian ethos. The Christian foundation which sponsors the CTC also…

  14. Analysing Religion and Education in Christian Academies

    ERIC Educational Resources Information Center

    Green, Elizabeth

    2012-01-01

    This paper asserts that the religious assumptions of Christian academies need to be fully examined in relation to any analysis of their cultural practices, impact or policy implications. It proposes that Bourdieu's concepts of habitus, cultural capital and symbolic power can be broadened out from their traditional use in accounting for social…

  15. Apprenticeship at the Academy of Music

    ERIC Educational Resources Information Center

    Nielsen, Klaus

    2006-01-01

    Inspired by studies of apprenticeship and theories of situated learning, this study argues that learning should be understood in relation to ongoing social practice. Using interview material and participant observation studying piano students' learning at the Academy of Music in Aarhus, it describes how transparency and access to the music culture…

  16. Comparison of Multilocus Sequence Typing and the Xpert C. difficile/Epi Assay for Identification of Clostridium difficile 027/NAP1/BI.

    PubMed

    McMillen, Tracy; Kamboj, Mini; Babady, N Esther

    2016-03-01

    Clostridium difficile 027/NAP1/BI is the most common C. difficile strain in the United States. The Xpert C. difficile/Epi assay allows rapid, presumptive identification of C. difficile NAP1. We compared Xpert C. difficile/Epi to multilocus sequence typing for identification of C. difficile NAP1 and found "very good" agreement at 97.9% (κ = 0.86; 95% confidence interval, 0.80 to 0.91).

  17. Predominance and high antibiotic resistance of the emerging Clostridium difficile genotypes NAPCR1 and NAP9 in a Costa Rican hospital over a 2-year period without outbreaks.

    PubMed

    López-Ureña, Diana; Quesada-Gómez, Carlos; Montoya-Ramírez, Mónica; del Mar Gamboa-Coronado, María; Somogyi, Teresita; Rodríguez, César; Rodríguez-Cavallini, Evelyn

    2016-01-01

    Clostridium difficile is the major causative agent of nosocomial antibiotic-associated diarrhea. In a 2009 outbreak of C. difficile-associated diarrhea that was recorded in a major Costa Rican hospital, the hypervirulent NAP1 strain (45%) predominated together with a local genotype variant (NAPCR1, 31%). Both strains were fluoroquinolone-resistant and the NAPCR1 genotype, in addition, was resistant to clindamycin and rifampicin. We now report on the genotypes and antibiotic susceptibilities of 68 C. difficile isolates from a major Costa Rican hospital over a 2-year period without outbreaks. In contrast to our previous findings, no NAP1 strains were detected, and for the first time in a Costa Rican hospital, a significant fraction of the isolates were NAP9 strains (n=14, 21%). The local NAPCR1 genotype remained prevalent (n=18, 26%) and coexisted with 14 strains (21%) of classic hospital NAP types (NAP2, NAP4, and NAP6), eight new genotypes (12%), four environmental strains classified as NAP10 or NAP11 (6%), three strains without NAP designation (4%) and seven non-toxigenic strains (10%). All 68 strains were resistant to ciprofloxacin, 88% were resistant to clindamycin and 50% were resistant to moxifloxacin and rifampicin. Metronidazole and vancomycin susceptibilities were universal. The NAPCR1 and NAP9 strains, which have been associated with more severe clinical infections, were more resistant to antibiotics than the other strains. Altogether, our results confirm that the epidemiology of C. difficile infection is dynamic and that A(-)B(+) strains from the NAP9 type are on the rise not only in the developed world. Moreover, our results reveal that the local NAPCR1 strains still circulate in the country without causing outbreaks but with equally high antibiotic-resistance rates and levels. PMID:27165560

  18. 75 FR 44276 - National Fire Academy Board of Visitors

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-28

    ... FR 39561) announcing a National Fire Academy Board of Visitors public teleconference meeting on... SECURITY Federal Emergency Management Agency National Fire Academy Board of Visitors AGENCY: Federal Emergency Management Agency, DHS. ACTION: Notice of cancellation of meeting. SUMMARY: The National...

  19. Radial Electromagnetic Press for Ignitor

    NASA Astrophysics Data System (ADS)

    Pizzuto, A.; Capriccioli, A.; Gasparotto, M.; Palmieri, A.; Rita, C.; Roccella, M.; Coppi, B.

    1996-11-01

    The active vertical press included so far in the Ignitor design can be substituted advantageously (e.g. in terms of the machine maintenance procedure) by a radial electromagnetic press, without involving modification of the main machine components. Only the bracing ring of the radial mechanical preloading system that is permanently applied requires some changes. The radial press has to compensate for the reduced ring load (from 200 MN to 120 MN) and the original vertical press load of 35 MN. To get an equivalent preloading system, the radial press load has to be 140 MN, which is 25 MN higher, to account for the lower efficiency of the radial load. The current needed to originate the 140 MN force is about 3.2 MA. The press is active for 2 s starting from the plasma current rise. The temperature increase is about 20 ^oC. The stray field at the plasma border is well within the allowable value and can be easily compensated by varying slightly the current of one couple of poloidal coils. The new machine layout is illustrated and the electromagnetic and mechanical analyses carried out for the new configuration are given. Sponsored by ENEA, CNR and ASP, of Italy, and by the US DoE

  20. 75 FR 18524 - National Fire Academy Board of Visitors

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-12

    ... SECURITY Federal Emergency Management Agency National Fire Academy Board of Visitors AGENCY: Federal... Meeting. ] SUMMARY: The National Fire Academy Board of Visitors will meet on April 28-29, 2010. DATES: The... background documents or comments received by the National Fire Academy Board of Visitors, go to...

  1. 76 FR 17425 - National Fire Academy Board of Visitors

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-29

    ... SECURITY Federal Emergency Management Agency National Fire Academy Board of Visitors AGENCY: Federal... Meeting. SUMMARY: The National Fire Academy Board of Visitors will meet on April 6-7, 2011. The meeting... the National Fire Academy Board of Visitors, go to http://www.regulations.gov . A public...

  2. 76 FR 20696 - National Fire Academy Board of Visitors

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-13

    ... Federal Register at 76 FR 17425 that the National Fire Academy Board of Visitors would meet on April 6 and... SECURITY Federal Emergency Management Agency National Fire Academy Board of Visitors AGENCY: Federal... National Fire Academy Board of Visitors meeting was held on Wednesday, April 6, 2011, from 8:30 a.m. to 5...

  3. 75 FR 2153 - National Fire Academy Board of Visitors

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-14

    ... SECURITY Federal Emergency Management Agency National Fire Academy Board of Visitors AGENCY: Federal... Advisory Committee Meeting. SUMMARY: The National Fire Academy Board of Visitors will meet by... documents or comments received by the National Fire Academy Board of Visitors, go to...

  4. 75 FR 39561 - National Fire Academy Board of Visitors

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-09

    ... SECURITY Federal Emergency Management Agency National Fire Academy Board of Visitors AGENCY: Federal... Meeting. SUMMARY: The National Fire Academy Board of Visitors will meet by teleconference on August 2... or comments received by the National Fire Academy Board of Visitors, go to...

  5. The U.S. Coast Guard Academy Curricula; An Evaluation.

    ERIC Educational Resources Information Center

    Powers, Theodore R.; And Others

    This report presents the results of research that had as its objective the evaluation of the curricula of the U.S. Coast Guard Academy. Over 125 Coast Guard officers and men were interviewed to gather detailed background information about the Coast Guard, the Coast Guard Academy, and job requirements of Academy graduates. These data were developed…

  6. Day of Dialogue: Research Priorities from the Researching Academies Conference

    ERIC Educational Resources Information Center

    Woods, Glenys J.; Woods, Philip A.

    2009-01-01

    The Researching Academies (RA) Conference, hosted by the University of Gloucestershire in Cheltenham on 12 November 2008 and organised by the authors, was a unique one-day event, funded as part of a research project (a case study of an Academy) supported by a British Academy (BA) grant, with additional support and funding from BELMAS. The RA…

  7. The Racial History of the U.S. Military Academies.

    ERIC Educational Resources Information Center

    Hansen, Susan D.

    1999-01-01

    Presents the history of the entry of African American students and faculty into the nation's prestigious military institutions: the U.S. Military Academy at West Point, the U.S. Naval Academy at Annapolis, and the U.S. Air Force Academy in Colorado Springs. Notes that the military's effort to diversify its troops and officer corps is a recent…

  8. Action Research at St Mark's Academy 2013

    ERIC Educational Resources Information Center

    Elwick, Alex, Ed.; Riggall, Anna, Ed.

    2013-01-01

    St Mark's Church of England Academy is an 11-18 academy situated in Mitcham, South London. It offers a commitment to high achievement within a community of care, underpinned by the Christian values of hope, love and trust. The academy encourages the development of the moral and spiritual well-being of students, alongside their academic…

  9. Haberdashers' Aske's: The Campaign against Academies in Lewisham

    ERIC Educational Resources Information Center

    Powell-Davies, Martin

    2008-01-01

    The National Union of Teachers' 2007 pamphlet "Academies--Looking Beyond the Spin: why the NUT calls for a different approach" lists six reasons why the NUT opposes Academies, schools run by private sponsors using public money. In this article, the Secretary of the Lewisham NUT presents evidence to show how the Academies operated by the…

  10. 75 FR 54086 - Global Intellectual Property Academy Program Survey

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-03

    ... Patent and Trademark Office Global Intellectual Property Academy Program Survey ACTION: Proposed... Property Academy Program Survey comment'' in the subject line of the message. Fax: 571-273-0112, marked to... Property Academy, United States Patent and Trademark Office, P.O. Box 1450, Alexandria, VA 22313-1450;...

  11. Selling Academies: Local Democracy and the Management of "Consultation"

    ERIC Educational Resources Information Center

    Hatcher, Richard

    2008-01-01

    Academies (state schools owned and run by private sponsors on a non-profit basis) are a key element in Labour's education agenda. Proposals to set up Academies, in most cases by taking over existing schools, have provoked local campaigns of opposition in many areas. Replacing a Local Authority with an Academy entails a process of consultation.…

  12. Work schedule and self-reported hypertension - the potential beneficial role of on-shift naps for night workers.

    PubMed

    Rotenberg, Lúcia; Silva-Costa, Aline; Vasconcellos-Silva, Paulo Roberto; Griep, Rosane Härter

    2016-01-01

    Data on the association between shift work and hypertension are controversial. Sleep restriction is hypothesized to be involved in this relationship. Since on-shift nap can partly compensate for sleep deprivation among night workers, this investigation is aimed at (i) comparing the prevalence of hypertension among workers considering both current and former night work, (ii) testing the association between on-shift naps and hypertension among night workers, and (iii) analyzing the influence of sleep complaints in the association between on-shift nap and hypertension. Nap was defined as a sleep episode with duration shorter than the average nighttime sleep. A cross-sectional study was performed at the 18 largest public hospitals in Rio de Janeiro, Brazil, in 2010-2011 (N = 2588 female registered nurses). Nurses were informally allowed to nap for up to three consecutive hours during working nights. Workers completed a multidimensional questionnaire including self-reported information on physician diagnosis of hypertension, napping, and sleep complaints (insomnia, diurnal sleepiness, and non-satisfactory sleep). Epidemiological and statistical treatment of data included binomial logistic regression and interaction tests. Higher chances of hypertension were observed for both current and former night workers compared with workers with no previous experience in night work, i.e. exclusive day workers (OR = 1.68; CI95% 1.22-2.33 and OR = 1.40; CI95% 1.01-1.96, respectively) after adjustment for age, race/ethnicity, physical activity, smoking, alcohol consumption, insomnia, weekly work hours, and BMI. Compared with exclusive day workers, both non-nappers and nappers were at a higher likelihood of reporting hypertension (OR = 1.93 CI95% 1.35-2.79 and OR = 1.41 CI95% 1.08-2.20, respectively). An interaction was observed between napping behavior and insomnia (p = 0.037). In the whole sample of night workers, the lower OR for nappers was confirmed when they were directly

  13. Work schedule and self-reported hypertension - the potential beneficial role of on-shift naps for night workers.

    PubMed

    Rotenberg, Lúcia; Silva-Costa, Aline; Vasconcellos-Silva, Paulo Roberto; Griep, Rosane Härter

    2016-01-01

    Data on the association between shift work and hypertension are controversial. Sleep restriction is hypothesized to be involved in this relationship. Since on-shift nap can partly compensate for sleep deprivation among night workers, this investigation is aimed at (i) comparing the prevalence of hypertension among workers considering both current and former night work, (ii) testing the association between on-shift naps and hypertension among night workers, and (iii) analyzing the influence of sleep complaints in the association between on-shift nap and hypertension. Nap was defined as a sleep episode with duration shorter than the average nighttime sleep. A cross-sectional study was performed at the 18 largest public hospitals in Rio de Janeiro, Brazil, in 2010-2011 (N = 2588 female registered nurses). Nurses were informally allowed to nap for up to three consecutive hours during working nights. Workers completed a multidimensional questionnaire including self-reported information on physician diagnosis of hypertension, napping, and sleep complaints (insomnia, diurnal sleepiness, and non-satisfactory sleep). Epidemiological and statistical treatment of data included binomial logistic regression and interaction tests. Higher chances of hypertension were observed for both current and former night workers compared with workers with no previous experience in night work, i.e. exclusive day workers (OR = 1.68; CI95% 1.22-2.33 and OR = 1.40; CI95% 1.01-1.96, respectively) after adjustment for age, race/ethnicity, physical activity, smoking, alcohol consumption, insomnia, weekly work hours, and BMI. Compared with exclusive day workers, both non-nappers and nappers were at a higher likelihood of reporting hypertension (OR = 1.93 CI95% 1.35-2.79 and OR = 1.41 CI95% 1.08-2.20, respectively). An interaction was observed between napping behavior and insomnia (p = 0.037). In the whole sample of night workers, the lower OR for nappers was confirmed when they were directly

  14. REM-Enriched Naps Are Associated with Memory Consolidation for Sad Stories and Enhance Mood-Related Reactivity

    PubMed Central

    Gilson, Médhi; Deliens, Gaétane; Leproult, Rachel; Bodart, Alice; Nonclercq, Antoine; Ercek, Rudy; Peigneux, Philippe

    2015-01-01

    Emerging evidence suggests that emotion and affect modulate the relation between sleep and cognition. In the present study, we investigated the role of rapid-eye movement (REM) sleep in mood regulation and memory consolidation for sad stories. In a counterbalanced design, participants (n = 24) listened to either a neutral or a sad story during two sessions, spaced one week apart. After listening to the story, half of the participants had a short (45 min) morning nap. The other half had a long (90 min) morning nap, richer in REM and N2 sleep. Story recall, mood evolution and changes in emotional response to the re-exposure to the story were assessed after the nap. Although recall performance was similar for sad and neutral stories irrespective of nap duration, sleep measures were correlated with recall performance in the sad story condition only. After the long nap, REM sleep density positively correlated with retrieval performance, while re-exposure to the sad story led to diminished mood and increased skin conductance levels. Our results suggest that REM sleep may not only be associated with the consolidation of intrinsically sad material, but also enhances mood reactivity, at least on the short term. PMID:26729175

  15. Nap environment control considering respiration rate and music tempo by using sensor agent robot

    NASA Astrophysics Data System (ADS)

    Nakaso, Sayaka; Mita, Akira

    2015-03-01

    We propose a system that controls a nap environment considering respiration rates and music tempo by using a sensor agent robot. The proposed system consists of two sub-systems. The first sub-system measures respiration rates using optical flow. We conducted preparatory experiments to verify the accuracy of this sub-system. The experimental results showed that this sub-system can measure the respiration rates accurately despite several positional relationships. It was also shown that the accuracy could be affected by clothes, movements and light. The second sub-system we constructed was the music play sub-system that chooses music with the certain tempo corresponding to the respiration rates measured by the first sub-system. We conducted verification experiments to verify the effectiveness of this music play sub-system. The experimental results showed the effectiveness of varying music tempo based on the respiration rates in taking a nap. We also demonstrated this system in a real environment; a subject entered into the room being followed by ebioNα. When the subject was considered sleeping, ebioNα started measuring respiration rates, controlling music based on the respiration rates. As a result, we showed that this system could be realized. As a next step, we would like to improve this system to a nap environment control system to be used in offices. To realize this, we need to update the first sub-system measuring respiration rates by removing disturbances. We also need to upgrade music play sub-system considering the numbers of tunes, the kinds of music and time to change music.

  16. Hanford Patrol Academy demolition sites closure plan

    SciTech Connect

    Not Available

    1993-09-30

    The Hanford Site is owned by the U.S. Government and operated by the U.S. Department of Energy, Richland Operations Office. Westinghouse Hanford Company is a major contractor to the U.S. Department of Energy, Richland Operations Office and serves as co-operator of the Hanford Patrol Academy Demolition Sites, the unit addressed in this paper. This document consists of a Hanford Facility Dangerous Waste Part A Permit Application, Form 3 (Revision 4), and a closure plan for the site. An explanation of the Part A Form 3 submitted with this closure plan is provided at the beginning of the Part A section. This Hanford Patrol Academy Demolition Sites Closure Plan submittal contains information current as of December 15, 1994.

  17. 7 CFR 550.29 - Press releases.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 6 2012-01-01 2012-01-01 false Press releases. 550.29 Section 550.29 Agriculture... Program Management § 550.29 Press releases. Press releases or other forms of public notification will be... opportunity to review, in advance, all written press releases and any other written information to be...

  18. 7 CFR 550.29 - Press releases.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 6 2013-01-01 2013-01-01 false Press releases. 550.29 Section 550.29 Agriculture... Program Management § 550.29 Press releases. Press releases or other forms of public notification will be... opportunity to review, in advance, all written press releases and any other written information to be...

  19. 7 CFR 550.29 - Press releases.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 6 2014-01-01 2014-01-01 false Press releases. 550.29 Section 550.29 Agriculture... Program Management § 550.29 Press releases. Press releases or other forms of public notification will be... opportunity to review, in advance, all written press releases and any other written information to be...

  20. 7 CFR 550.29 - Press releases.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Press releases. 550.29 Section 550.29 Agriculture... Program Management § 550.29 Press releases. Press releases or other forms of public notification will be... opportunity to review, in advance, all written press releases and any other written information to be...

  1. 7 CFR 550.29 - Press releases.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 6 2011-01-01 2011-01-01 false Press releases. 550.29 Section 550.29 Agriculture... Program Management § 550.29 Press releases. Press releases or other forms of public notification will be... opportunity to review, in advance, all written press releases and any other written information to be...

  2. Histone density is maintained during transcription mediated by the chromatin remodeler RSC and histone chaperone NAP1 in vitro.

    PubMed

    Kuryan, Benjamin G; Kim, Jessica; Tran, Nancy Nga H; Lombardo, Sarah R; Venkatesh, Swaminathan; Workman, Jerry L; Carey, Michael

    2012-02-01

    ATPases and histone chaperones facilitate RNA polymerase II (pol II) elongation on chromatin. In vivo, the coordinated action of these enzymes is necessary to permit pol II passage through a nucleosome while restoring histone density afterward. We have developed a biochemical system recapitulating this basic process. Transcription through a nucleosome in vitro requires the ATPase remodels structure of chromatin (RSC) and the histone chaperone nucleosome assembly protein 1 (NAP1). In the presence of NAP1, RSC generates a hexasome. Despite the propensity of RSC to evict histones, NAP1 reprograms the reaction such that the hexasome is retained on the template during multiple rounds of transcription. This work has implications toward understanding the mechanism of pol II elongation on chromatin. PMID:22308335

  3. Histone density is maintained during transcription mediated by the chromatin remodeler RSC and histone chaperone NAP1 in vitro.

    PubMed

    Kuryan, Benjamin G; Kim, Jessica; Tran, Nancy Nga H; Lombardo, Sarah R; Venkatesh, Swaminathan; Workman, Jerry L; Carey, Michael

    2012-02-01

    ATPases and histone chaperones facilitate RNA polymerase II (pol II) elongation on chromatin. In vivo, the coordinated action of these enzymes is necessary to permit pol II passage through a nucleosome while restoring histone density afterward. We have developed a biochemical system recapitulating this basic process. Transcription through a nucleosome in vitro requires the ATPase remodels structure of chromatin (RSC) and the histone chaperone nucleosome assembly protein 1 (NAP1). In the presence of NAP1, RSC generates a hexasome. Despite the propensity of RSC to evict histones, NAP1 reprograms the reaction such that the hexasome is retained on the template during multiple rounds of transcription. This work has implications toward understanding the mechanism of pol II elongation on chromatin.

  4. Benefits of napping and an extended duration of recovery sleep on alertness and immune cells after acute sleep restriction.

    PubMed

    Faraut, Brice; Boudjeltia, Karim Zouaoui; Dyzma, Michal; Rousseau, Alexandre; David, Elodie; Stenuit, Patricia; Franck, Thierry; Van Antwerpen, Pierre; Vanhaeverbeek, Michel; Kerkhofs, Myriam

    2011-01-01

    Understanding the interactions between sleep and the immune system may offer insight into why short sleep duration has been linked to negative health outcomes. We, therefore, investigated the effects of napping and extended recovery sleep after sleep restriction on the immune and inflammatory systems and sleepiness. After a baseline night, healthy young men slept for a 2-h night followed by either a standard 8-h recovery night (n=12), a 30-min nap (at 1 p.m.) in addition to an 8-h recovery night (n=10), or a 10-h extended recovery night (n=9). A control group slept 3 consecutive 8-h nights (n=9). Subjects underwent continuous electroencephalogram polysomnography and blood was sampled every day at 7 a.m. Leukocytes, inflammatory and atherogenesis biomarkers (high-sensitivity C-reactive protein, interleukin-8, myeloperoxidase, fibrinogen and apolipoproteins ApoB/ApoA), sleep patterns and sleepiness were investigated. All parameters remained unchanged in the control group. After sleep restriction, leukocyte and - among leukocyte subsets - neutrophil counts were increased, an effect that persisted after the 8-h recovery sleep, but, in subjects who had a nap or a 10-h recovery sleep, these values returned nearly to baseline. Inflammatory and atherogenesis biomarkers were unchanged except for higher myeloperoxidase levels after sleep restriction. The increased sleepiness after sleep restriction was reversed better in the nap and extended sleep recovery conditions. Saliva cortisol decreased immediately after the nap. Our results indicate that additional recovery sleep after sleep restriction provided by a midday nap prior to recovery sleep or a sleep extended night can improve alertness and return leukocyte counts to baseline values.

  5. Enhancement of Declarative Memory Performance Following a Daytime Nap Is Contingent on Strength of Initial Task Acquisition

    PubMed Central

    Tucker, Matthew A.; Fishbein, William

    2008-01-01

    Study Objectives: In this study we examined the benefit of a daytime nap containing only NREM sleep on the performance of three declarative memory tasks: unrelated paired associates, maze learning, and the Rey-Osterrieth complex figure. Additionally, we explored the impact of factors related to task acquisition on sleep-related memory processing. To this end, we examined whether testing of paired associates during training leads to sleep-related enhancement of memory compared to simply learning the word pairs without test. We also examined whether strength of task acquisition modulates sleep-related processing for each of the three tasks. Subjects and Procedure: Subjects (11 male, 22 female) arrived at 11:30, were trained on each of the declarative memory tasks at 12:15, and at 13:00 either took a nap or remained awake in the sleep lab. After the nap period, all subjects remained in the lab until retest at 16:00. Results: Compared to subjects who stayed awake during the training-retest interval, subjects who took a NREM nap demonstrated enhanced performance for word pairs that were tested during training, but not for untested word pairs. For each of the three declarative memory tasks, we observed a sleep-dependent performance benefit only for subjects that most strongly acquired the tasks during the training session. Conclusions: NREM sleep obtained during a daytime nap benefits declarative memory performance, with these benefits being intimately tied to how well subjects acquire the tasks and the way in which the information is acquired. Citation: Tucker MA; Fishbein W. Enhancement of declarative memory performance following a daytime nap is contingent on strength of initial task acquisition. SLEEP 2008;31(2):197–203. PMID:18274266

  6. STEM Summer Academy on the Navajo Reservation

    NASA Astrophysics Data System (ADS)

    Alexander, C. J.

    2012-12-01

    The US Rosetta Project is the NASA contribution to the International Rosetta Mission, an ESA cornerstone mission to comet Churyumov-Gerasimenko. While the project's outreach efforts span multi-media, and a variety of age and ethnic groups, a special emphasis has been made to find a way to provide meaningful outreach to the reservation communities. Because language preservation is an issue of urgent concern to the reservation communities, and because Rosetta, uniquely among NASA missions, has been named after the notion that keys to missing understanding of elements of the ancient past were found in the language on the original Rosetta stone, the US Rosetta Project has embarked upon outreach with a focus on STEM vocabulary in ancient US languages of the Navajo, Hopi, Ojibwe, and other tribal communities as the project expands. NASA image and science are used and described in the native language, alongside lay English and scientific English curriculum elements. Additionally, science (geology/chemistry/botany/physics) elements drawn from the reservation environment, including geomorphology, geochemistry, soil physics, are included and discussed in the native language as much as possible — with their analogs in other planetary environments (such as Mars). In this paper we will report on the most recent Summer Science Academy [2012], a four week summer course for middle school children, created in collaboration with teachers and administrators in the Chinle Unified School District. The concept of the Academy was initiated in 2011, and the first Academy was conducted shortly thereafter, in June 2011 with 14 children, 3 instructors, and a NASA teacher workshop. The community requested three topics: geology, astronomy, and botany. The 2012 Academy built on the curriculum already developed with more robust field trips, addressed to specific science topics, additional quantitative measurements and activities, with more written material for the cultural components from

  7. Synthesis of NaP zeolite at room temperature and short crystallization time by sonochemical method.

    PubMed

    Pal, Pameli; Das, Jugal K; Das, Nandini; Bandyopadhyay, Sibdas

    2013-01-01

    NaP zeolite nano crystals were synthesized by sonochemical method at room temperature with crystallization time of 3h. For comparison, to insure the effect of sonochemical method, the hydrothermal method at conventional synthesis condition, with same initial sol composition was studied. NaP zeolites are directly formed by ultrasonic treatment without the application of autogenous pressure and also hydrothermal treatment. The effect of ultrasonic energy and irradiation time showed that with increasing sonication energy, the crystallinity of the powders decreased but phase purity remain unchanged. The synthesized powders were characterized by XRD, IR, DTA TGA, FESEM, and TEM analysis. FESEM images revealed that 50 nm zeolite crystals were formed at room temperature by using sonochemical method. However, agglomerated particles having cactus/cabbage like structure was obtained by sonochemical method followed by hydrothermal treatment. In sonochemical process, formation of cavitation and the collapsing of bubbles produced huge energy which is sufficient for crystallization of zeolite compared to that supplied by hydrothermal process for conventional synthesis. With increasing irradiation energy and time, the crystallinity of the synthesized zeolite samples increased slightly.

  8. Napping during the night shift and recovery after work among hospital nurses1

    PubMed Central

    Palermo, Thaís Aparecida de Castro; Rotenberg, Lúcia; Zeitoune, Regina Célia Gollner; Silva-Costa, Aline; Souto, Ester Paiva; Griep, Rosane Härter

    2015-01-01

    OBJECTIVE: To analyze the association between the length of napping during the night shift and the recovery after work among nurses. METHOD: Cross-sectional epidemiological study involving 1940 nurses from 18 public hospitals in the City of Rio de Janeiro. A multidimensional and self-applied questionnaire was used with information about health, sociodemographic and occupational characteristics, health-related behaviors and housework. Multiple logistic regression was applied to identify the association, adjusted for confounding variables. RESULTS: The gross analyses showed 44%, 127% and 66% higher chances of a high level of recovery after work for nurses who sleep up to two hours, between 2.1 and 3 hours and 3.1 hours or more, respectively, when compared to the nurses who do not sleep. After adjusting for confounding variables, the association only continues significant for the group that sleeps 2.1 to 3 hours during the night shift (OR=1.79; 95%CI=1.33-2.41). CONCLUSION: The association between the length of napping and the high level of recovery after work, confirmed in the present results, can be included in the studies that aim to support more appropriate policies aimed at improving the workers' work, life and health conditions, not only in nursing, but night-shift workers in general. PMID:25806639

  9. No first night shift effect observed following a nocturnal main sleep and a prophylactic 1-h afternoon nap.

    PubMed

    Kosmadopoulos, Anastasi; Zhou, Xuan; Roach, Gregory D; Darwent, David; Sargent, Charli

    2016-01-01

    Neurobehavioural impairment on the first night shift is often greater than on subsequent night shifts due to extended wakefulness. The aim of the study was to determine whether a 1-h afternoon nap prior to the first night shift is sufficient to produce neurobehavioural performance at levels comparable to the second night shift. Twelve male volunteers (mean age 22.9 years) participated in a laboratory protocol that simulated two 12-h night shifts. A nap preceded the first shift and a 7-h daytime sleep was scheduled between shifts. Neurobehavioural performance and subjective sleepiness measured across each night did not significantly differ between first and second shifts. PMID:27077691

  10. A brief nap is beneficial for human route-learning: The role of navigation experience and EEG spectral power.

    PubMed

    Wamsley, Erin J; Tucker, Matthew A; Payne, Jessica D; Stickgold, Robert

    2010-07-01

    Here, we examined the effect of a daytime nap on changes in virtual maze performance across a single day. Participants either took a short nap or remained awake following training on a virtual maze task. Post-training sleep provided a clear performance benefit at later retest, but only for those participants with prior experience navigating in a three-dimensional (3D) environment. Performance improvements in experienced players were correlated with delta-rich stage 2 sleep. Complementing observations that learning-related brain activity is reiterated during post-navigation NREM sleep in rodents, the present data demonstrate that NREM sleep confers a performance advantage for spatial memory in humans.

  11. SNPs in the CpG island of NAP1L2: a possible link between DNA methylation and neural tube defects?

    PubMed

    Rogner, Ute Christine; Danoy, Patrick; Matsuda, Fumihiko; Moore, Gudrun Elizabeth; Stanier, Philip; Avner, Philip

    2002-07-01

    Deletion of the murine X-linked Nap1l2 gene causes lethality from midgestation onwards. The affected embryos exhibit neural tube defects (NTDs) closely resembling spina bifida and anencephaly in humans. X-linked familial and spontaneous cases of NTD were analyzed for sequence alterations in the human NAP1L2. No differences were found in the familial cases. However, a number of single nucleotide polymorphisms (SNPs) within the 5' region of NAP1L2 were identified both in cases of spontaneous NTD and in normal controls. Most of these SNPs lead to the replacement of guanidines or cytosines within a CpG island that is conserved between the human and the mouse promoter regions. Demethylation in vitro activates Nap1l2 transcriptional activity, suggesting the importance of the CpG island in regulating the activity of the Nap1l2/NAP1L2 genes, and the potential importance of the polymorphisms in modifying their transcriptional activity. NAP1L2/Nap1l2 expression may therefore depend on the genetic-environmental factors that are frequently associated with NTDs.

  12. Characterization of Clostridium difficile Strains in British Columbia, Canada: A Shift from NAP1 Majority (2008) to Novel Strain Types (2013) in One Region

    PubMed Central

    Jassem, Agatha N.; Prystajecky, Natalie; Marra, Fawziah; Kibsey, Pamela; Tan, Kennard; Umlandt, Patricia; Janz, Loretta; Champagne, Sylvie; Gamage, Bruce; Golding, George R.; Mulvey, Michael R.; Henry, Bonnie

    2016-01-01

    Background. Clostridium difficile is a major cause of gastrointestinal illness. Epidemic NAP1 strains contain toxins A and B, a deletion in repressor tcdC, and a binary toxin. Objectives. To determine the molecular epidemiology of C. difficile in British Columbia and compare between two time points in one region. Methods. C. difficile isolates from hospital and community laboratories (2008) and one Island Health hospital laboratory (2013) were characterized by pulsed-field gel electrophoresis, PCR-ribotyping, toxin possession, tcdC genotype, and antimicrobial susceptibility. Results. In 2008, 42.7% of isolates had NAP1 designation. Hospital-collected isolates were associated with older patients and more NAP1 types. Unlike other isolates, most NAP1 isolates possessed binary toxin and a 19 bp loss in tcdC. All isolates were susceptible to metronidazole and vancomycin. A 2013 follow-up revealed a 28.9% decrease in NAP1 isolates and 20.0% increase in isolates without NAP designation in one region. Then, community-associated cases were seen in younger patients, while NAP types were evenly distributed. Isolates without NAP designation did not cluster with a PFGE pattern or ribotype. Conclusions. Evaluation of C. difficile infections within British Columbia revealed demographic associations, epidemiological shifts, and characteristics of strain types. Continuous surveillance of C. difficile will enable detection of emerging strains. PMID:27366181

  13. Apollo 13 Facts: Press Conference

    NASA Technical Reports Server (NTRS)

    2001-01-01

    Flight Director Gene Krantz gives an overview of the Apollo 13 mission as corrections are made in the power down checklist, passive thermal control, and orbital burns after the spacecraft runs into problems. He then answers questions from the press with the help of Tony England, Bill Peters, and Dick Thorson. Footage then shows newspaper headlines 'We're Not Concerned' and 'Getting Ready to Land' as people watch televisions to see if the astronauts landed safely. The press conference section of this video has sound, the headlines section does not.

  14. Hot isostatic pressing: Conference proceedings

    SciTech Connect

    Froes, F.H.; Hebeisen, J.; Widmer, R.

    1996-12-31

    The International Conference on Hot Isostatic Pressing was held on May 20-22, 1996, in Andover, Massachusetts. This conference discussed the state-of-the-art of hot isostatic pressing (HIP) and competing compaction techniques. HIP allows complex cost-effective near net shapes to be produced from powder products, densification of castings thereby enhancing performance, retention of metastable structures such as nano-sized grains, and even creative food processing. Sections in the conference covered such items as fundamentals, mathematical modeling, equipment and instrumentation, advanced materials and processes, composite materials, casting densification, surface treatments, HIP bonding, and competing technologies. Forty five papers were processed separately for inclusion on the data base.

  15. Daytime Napping and the Risk of Cardiovascular Disease and All-Cause Mortality: A Prospective Study and Dose-Response Meta-Analysis

    PubMed Central

    Yamada, Tomohide; Hara, Kazuo; Shojima, Nobuhiro; Yamauchi, Toshimasa; Kadowaki, Takashi

    2015-01-01

    Study Objectives: To summarize evidence about the association between daytime napping and the risk of cardiovascular disease and all-cause mortality, and to quantify the potential dose-response relation. Design: Meta-analysis of prospective cohort studies. Methods and Results: Electronic databases were searched for articles published up to December 2014 using the terms nap, cardiovascular disease, and all-cause mortality. We selected well-adjusted prospective cohort studies reporting risk estimates for cardiovascular disease and all-cause mortality related to napping. Eleven prospective cohort studies were identified with 151,588 participants (1,625,012 person-years) and a mean follow-up period of 11 years (60% women, 5,276 cardiovascular events, and 18,966 all-cause deaths). Pooled analysis showed that a long daytime nap (≥ 60 min/day) was associated with a higher risk of cardiovascular disease (rate ratio [RR]: 1.82 [1.22–2.71], P = 0.003, I2 = 37%) compared with not napping. All-cause mortality was associated with napping for ≥ 60 min/day (RR: 1.27 [1.11–1.45], P < 0.001, I2 = 0%) compared with not napping. In contrast, napping for < 60 min/day was not associated with cardiovascular disease (P = 0.98) or all-cause mortality (P = 0.08). Meta-analysis demonstrated a significant J-curve dose-response relation between nap time and cardiovascular disease (P for nonlinearity = 0.01). The RR initially decreased from 0 to 30 min/day. Then it increased slightly until about 45 min/day, followed by a sharp increase at longer nap times. There was also a positive linear relation between nap time and all-cause mortality (P for non-linearity = 0.97). Conclusions: Nap time and cardiovascular disease may be associated via a J-curve relation. Further studies are needed to confirm the efficacy of a short nap. Citation: Yamada T, Hara K, Shojima N, Yamauchi T, Kadowaki T. Daytime napping and the risk of cardiovascular disease and all-cause mortality: a prospective study and

  16. Job demands and resting and napping opportunities for nurses during night shifts: impact on sleepiness and self-evaluated quality of healthcare

    PubMed Central

    BARTHE, Béatrice; TIRILLY, Ghislaine; GENTIL, Catherine; TOUPIN, Cathy

    2015-01-01

    The aim of this field study is to describe night shift resting and napping strategies and to examine their beneficial effects on sleepiness and quality of work. The study was carried out with 16 nurses working in an intensive care unit. Data collected during 20 night shifts were related to job demands (systematic observations), to the duration and timing of rests and naps taken by nurses (systematic observations, sleep diaries), to sleepiness (Karolinska Sleepiness Scale), and to quality of work scores (visual analog scale). The results showed that the number of rests and naps depended on the job demands. Resting and napping lowered the levels of sleepiness at the end of the shift. There was no direct relationship between sleepiness and the quality of work score. Discussions about the choice of indicators for the quality of work are necessary. Suggestions for implementing regulations for prescribed napping during night shifts are presented. PMID:26537999

  17. Geothermal Academy: Focus Center for Data Collection, Analysis, and Dissemination

    SciTech Connect

    Nakagawa, Masami, Ph.D.; Fujiono, Hendro, Ph.D.; McCartney, John S., Ph.D.; Reed, Adam, J.D., Esq.

    2011-10-31

    Geothermal Academy: A Pathway for Confirmation of Ground-Source Heat Pumps in the United States. In 2008, Oak Ridge National Laboratory issued a report on geothermal heats pumps (GHPs) focused on the market status, barriers to adoption, and actions to overcome these barriers (Hughes 2008). Of the barriers raised in this report, of the most pressing is the lack of performance and energy usage data for GHPs. Further, an associated barrier is a lack of a fair comparison of the energy usage of conventional heating and cooling systems for the same building. Because of these barriers, we are not able to say how much energy is used by well-designed GHP systems on a long-term basis, nor are we able to say how better their energy usage is compared to conventional systems. The need for a fair comparison with conventional systems is particularly relevant as modern versions of conventional air conditioners, gas furnaces, and boilers have also incorporated energy saving technologies. As a first step to address this barrier, the Geothermal Academy has developed a framework for data collection. This framework has already been applied to several geothermal installations in Colorado (Nakagawa etal. 2010). The framework classifies data into different categories based on the relevance of the dat to understanding the energy consumption of a GHP system. The categories are: direct energy consumption data, heat exchange performance data, and GHP design parameter data. The main recommendation of this project is to include a minimal data collection system on each heat pump installed in the U.S., capable of measuring the electrical energy consumed, the entering/exiting fluid temperatures, and circulation rates. This is a viable and cost effective solution which will provide performance data, as data collection systems are only a fraction of the cost of a GHP unit and modern GHP units already incorporate sensors to monitor energy usage and the entering and exiting fluid temperatures

  18. Censorship and the Student Press.

    ERIC Educational Resources Information Center

    Oettinger, Lauren

    The First Amendment rights provided to journalists--freedom of speech and of the press--are fundamental beliefs held by Americans. What students learn in the government class, however, may not be what they learn as editors-in-chief of student newspapers. U.S. schools are being charged with the censorship of student publications at an…

  19. Law and the Student Press.

    ERIC Educational Resources Information Center

    Stevens, George E.; Webster, John B.

    Court cases and legal decisions involving the student press in the late 1960s and early 1970s are brought together in this book in order to show how the law has been applied to school officials and student journalists in high school, college, and the underground. The ten chapters cover the following topics: censorship, libel, obscenity, contempt,…

  20. Gifted Education Press Quarterly, 1995.

    ERIC Educational Resources Information Center

    Fisher, Maurice D., Ed.

    1995-01-01

    This document consists of the four issues of the newsletter "Gifted Education Press Quarterly" published during 1995. This newsletter addresses issues in the education of gifted children and youth. The major articles are: (1) "Using Today's Technology: Parents Can Help Challenge Gifted Children" (Adrienne O'Neill); (2) "Outcomes-Based Education…

  1. The Alternative Press in Microform.

    ERIC Educational Resources Information Center

    Tsang, Daniel C.

    Presented is an analysis of what has been done regarding the preservation of alternative publications in microfilm. The alternative press was defined, for the purposes of this study, as "nonstandard, nonestablishment publications." Two projects undertaken to microfilm such publications, one by the Microphoto Division of Bell and Howell and the…

  2. Mars Observer Press Conference JPL

    NASA Technical Reports Server (NTRS)

    1993-01-01

    The Mars Observer mission spacecraft was primarily designed for exploring Mars and the Martian environment. The Mars Observer was launched on September 25, 1992. The spacecraft was lost in the vicinity of Mars on August 21, 1993 when the spacecraft began its maneuvering sequence for Martian orbital insertion. This videotape shows a press briefing, held after the spacecraft had not responded to attempts to communicate with it, to explain to the press the problems and the steps that were being taken to re-establish communication with the spacecraft. The communications had been shutdown prior to the orbital insertion burn to protect the instruments. At the time of the press conference, the communications system was still not operational, and attempts were being made to re-establish communication. Bob McMillan of the Public Affairs Office at JPL gives the initial announcement of the continuing communication problem with the spacecraft. Mr. McMillan introduces William Piotrowski, acting director of solar system exploration, who reiterates that there is indeed no communication with the Observer spacecraft. He is followed by Glenn Cunningham, the Project Manager of the Mars Observer who speaks about the attempts to re-establish contact. Mr. Cunningham is followed by Satenios Dallas, the Mission Manager for the Mars Observer Project, who speaks about the sequence of events leading up to the communication failure, and shows an animated video presenting the orbital insertion maneuvers. The briefing was then opened up for questions from the assembled press, both at JPL and at the other NASA Centers. The questions are about the possible reasons for the communication failure, and the attempts to restore communications with the spacecraft. Dr. Arden L. Albee, chief scientist for the Mars Observer Mission, joins the other panel members to answer questions. At the end of the press briefing the animation of the Mars orbital insertion is shown again.

  3. The Teachers Academy for Mathematics and Science

    SciTech Connect

    Not Available

    1992-01-01

    In his State of the Union address on January 31, 1990, President Bush set a goal for US students to be number one in the world in mathematics and science achievement by the year 2000. The Teachers Academy for Mathematics and Science in Chicago is an experiment of unprecedented boldness and scale that can provide a means to the President's goal, both for the Chicago area and as a national model. This document covers organization and governance, program activities, future training goals, and evaluation programs.

  4. Sleep and Behavioral Correlates of Napping among Young Adults: A Survey of First-Year University Students in Madrid, Spain

    ERIC Educational Resources Information Center

    Vela-Bueno, Antonio; Fernandez-Mendoza, Julio; Olavarrieta-Bernardino, Sara; Vgontzas, Alexandros N.; Bixler, Edward O.; de la Cruz-Troca, Juan Jose; Rodriguez-Munoz, Alfredo; Olivan-Palacios, Jesus

    2008-01-01

    Objective: Between November 2002 and March 2003, the authors assessed the prevalence and correlates of napping among Spanish university students. Participants: The sample comprised 1,276 first-year university students; the mean age was 18.74 [plus or minus] 1.24 years, and 35.45% were men. Methods: The study was cross-sectional, and the students…

  5. NAP1-assisted nucleosome assembly on DNA measured in real time by single-molecule magnetic tweezers.

    PubMed

    Vlijm, Rifka; Smitshuijzen, Jeremy S J; Lusser, Alexandra; Dekker, Cees

    2012-01-01

    While many proteins are involved in the assembly and (re)positioning of nucleosomes, the dynamics of protein-assisted nucleosome formation are not well understood. We study NAP1 (nucleosome assembly protein 1) assisted nucleosome formation at the single-molecule level using magnetic tweezers. This method allows to apply a well-defined stretching force and supercoiling density to a single DNA molecule, and to study in real time the change in linking number, stiffness and length of the DNA during nucleosome formation. We observe a decrease in end-to-end length when NAP1 and core histones (CH) are added to the dsDNA. We characterize the formation of complete nucleosomes by measuring the change in linking number of DNA, which is induced by the NAP1-assisted nucleosome assembly, and which does not occur for non-nucleosomal bound histones H3 and H4. By rotating the magnets, the supercoils formed upon nucleosome assembly are removed and the number of assembled nucleosomes can be counted. We find that the compaction of DNA at low force is about 56 nm per assembled nucleosome. The number of compaction steps and associated change in linking number indicate that NAP1-assisted nucleosome assembly is a two-step process. PMID:23050009

  6. The Role of Implied Motion in Engaging Audiences for Health Promotion: Encouraging Naps on a College Campus

    ERIC Educational Resources Information Center

    Mackert, Michael; Lazard, Allison; Guadagno, Marie; Hughes Wagner, Jessica

    2014-01-01

    Objective: Lack of sleep among college students negatively impacts health and academic outcomes. Building on research that implied motion imagery increases brain activity, this project tested visual design strategies to increase viewers' engagement with a health communication campaign promoting napping to improve sleep habits. Participants:…

  7. Optimizing sleep/wake schedules in space: Sleep during chronic nocturnal sleep restriction with and without diurnal naps

    NASA Astrophysics Data System (ADS)

    Mollicone, Daniel J.; Van Dongen, Hans P. A.; Dinges, David F.

    2007-02-01

    Effective sleep/wake schedules for space operations must balance severe time constraints with allocating sufficient time for sleep in order to sustain high levels of neurobehavioral performance. Developing such schedules requires knowledge about the relationship between scheduled "time in bed" (TIB) and actual physiological sleep obtained. A ground-based laboratory study in N=93 healthy adult subjects was conducted to investigate physiological sleep obtained in a range of restricted sleep schedules. Eighteen different conditions with restricted nocturnal anchor sleep, with and without diurnal naps, were examined in a response surface mapping paradigm. Sleep efficiency was found to be a function of total TIB per 24 h regardless of how the sleep was divided among nocturnal anchor sleep and diurnal nap sleep periods. The amounts of sleep stages 1+2 and REM showed more complex relationships with the durations of the anchor and nap sleep periods, while slow-wave sleep was essentially preserved among the different conditions of the experiment. The results of the study indicated that when sleep was chronically restricted, sleep duration was largely unaffected by whether the sleep was placed nocturnally or split between nocturnal anchor sleep periods and daytime naps. Having thus assessed that split-sleep schedules are feasible in terms of obtaining physiological sleep, further research will reveal whether these schedules and the associated variations in the distribution of sleep stages may be advantageous in mitigating neurobehavioral performance impairment in the face of limited time for sleep.

  8. [The National Academy of Medicine of Mexico (1836-1912)].

    PubMed

    Rodríguez Pérez, Martha Eugenia

    2013-01-01

    The article presents a summary of the development of the National Academy of Medicine of Mexico since its beginnings in 1836, when the first Academy was created, until 1912 when the organization became an official institution and an advisory authority for the Federal Government. The different stages that the Academy has gone through show the dynamism of the corporation and the activity and energy of its members. As a whole, they advanced medicine in the country at the same time as the Academy fought for the recognition, consolidation, and support of its research.

  9. Long-Term Single and Joint Effects of Excessive Daytime Napping on the HOMA-IR Index and Glycosylated Hemoglobin

    PubMed Central

    Li, Xue; Pang, Xiuyu; Zhang, Qiao; Qu, Qiannuo; Hou, Zhigang; Liu, Zhipeng; Lv, Lin; Na, Guanqiong; Zhang, Wei; Sun, Changhao; Li, Ying

    2016-01-01

    Abstract This prospective cohort study was conducted to assess the duration of daytime napping and its effect combined with night sleep deprivation on the risk of developing high HOMA-IR (homeostasis model assessment of insulin resistance) index and disadvantageous changes in glycosylated hemoglobin (HbA1c) levels. A total of 5845 diabetes-free subjects (2736 women and 3109 men), 30 to 65 years of age, were targeted for this cohort study since 2008. Multiple adjusted Cox regression models were performed to evaluate the single and joint effects of daytime napping on the risk of an elevated HbA1c level and high HOMA-IR index. After an average of 4.5 years of follow-up, >30 minutes of daytime napping was significantly associated with an increased risk of an elevated HbA1c level (>6.5%) in men and women (all P trend < 0.05). Hazard ratios (HRs) for an HbA1c level between 5.7% and 6.4% were also significant in the entire cohort and women, but nonsignificant in men. HRs (95% confidence interval, CIs) for the high HOMA-IR index in the entire cohort, men, and women were 1.33 (1.10–1.62), 1.46 (1.08–1.98), and 1.47 (1.12–1.91), respectively. The combination of sleep deprivation with no naps or >30 minutes napping and the combination of no sleep deprivation with >30 minutes daytime napping were all associated with an HbA1c level >6.5% (HR = 2.08, 95% CI = 1.24–3.51; HR = 4.00, 95% CI = 2.03–7.90; and HR = 2.05, 95% CI = 1.29–3.27, respectively). No sleep deprivation combined with >30 minutes daytime napping correlated with a high risk of an HbA1c level between 5.7% and 6.4% and high HOMA-IR index (HR = 2.12, 95% CI = 1.48–3.02; and HR = 1.35, 95% CI = 1.10–1.65, respectively). Daytime napping >30 minutes was associated with a high risk of an elevated HbA1c level and high HOMA-IR index. No sleep deprivation combined with napping >30 minutes carries a risk of abnormal glucose metabolism. Sleep deprivation combined with

  10. Fusion/Astrophysics Teacher Research Academy

    NASA Astrophysics Data System (ADS)

    Correll, Donald

    2005-10-01

    In order to engage California high school science teachers in the area of plasma physics and fusion research, LLNL's Fusion Energy Program has partnered with the UC Davis Edward Teller Education Center, ETEC (http://etec.ucdavis.edu), the Stanford University Solar Center (http://solar-center.stanford.edu) and LLNL's Science / Technology Education Program, STEP (http://education.llnl.gov). A four-level ``Fusion & Astrophysics Research Academy'' has been designed to give teachers experience in conducting research using spectroscopy with their students. Spectroscopy, and its relationship to atomic physics and electromagnetism, provides for an ideal plasma `bridge' to the CA Science Education Standards (http://www.cde.ca.gov/be/st/ss/scphysics.asp). Teachers attend multiple-day professional development workshops to explore new research activities for use in the high school science classroom. A Level I, 3-day program consists of two days where teachers learn how plasma researchers use spectrometers followed by instructions on how to use a research grade spectrometer for their own investigations. A 3rd day includes touring LLNL's SSPX (http://www.mfescience.org/sspx/) facility to see spectrometry being used to measure plasma properties. Spectrometry classroom kits are made available for loaning to participating teachers. Level I workshop results (http://education.llnl.gov/fusion&_slash;astro/) will be presented along with plans being developed for Level II (one week advanced SKA's), Level III (pre-internship), and Level IV (summer internship) research academies.

  11. Optimal guidance with obstacle avoidance for nap-of-the-earth flight

    NASA Technical Reports Server (NTRS)

    Pekelsma, Nicholas J.

    1988-01-01

    The development of automatic guidance is discussed for helicopter Nap-of-the-Earth (NOE) and near-NOE flight. It deals with algorithm refinements relating to automated real-time flight path planning and to mission planning. With regard to path planning, it relates rotorcraft trajectory characteristics to the NOE computation scheme and addresses real-time computing issues and both ride quality issues and pilot-vehicle interfaces. The automated mission planning algorithm refinements include route optimization, automatic waypoint generation, interactive applications, and provisions for integrating the results into the real-time path planning software. A microcomputer based mission planning workstation was developed and is described. Further, the application of Defense Mapping Agency (DMA) digital terrain to both the mission planning workstation and to automatic guidance is both discussed and illustrated.

  12. A laser image generation system for helicopter Nap-Of-the-Earth (NOE) flight training

    NASA Astrophysics Data System (ADS)

    Tong, H. M.

    1983-11-01

    The training effectiveness of the camera-modelboard visual system for low-altitude, nap-of-the-earth (NOE) flights, particularly for helicopters, is well established. Traditional camera-modelboard technology, however, has a number of inherent limitations which have been overcome by using a laser image generator instead of a TV camera as in the current generation of camera-modelboard systems. The first full-scale Laser Image Generation (LIG) visual system, developed by Singer-Link under the AH-lS Cobra Helicopter Flight Weapons Simulator contract, will be delivered to the U.S. Army in the near future. This new visual system offers improvements in many areas, some of which are discussed in this paper, together with the visual system technology involved and performance parameters achieved on the AH-lS simulator.

  13. Intranasal NAP (davunetide) decreases tau hyperphosphorylation and moderately improves behavioral deficits in mice overexpressing α-synuclein

    PubMed Central

    Magen, Iddo; Ostritsky, Regina; Richter, Franziska; Zhu, Chunni; Fleming, Sheila M; Lemesre, Vincent; Stewart, Alistair J; Morimoto, Bruce H; Gozes, Illana; Chesselet, Marie-Françoise

    2014-01-01

    Genome-wide association studies have identified strong associations between the risk of developing Parkinson's disease (PD) and polymorphisms in the genes encoding α-synuclein and the microtubule-associated protein tau. However, the contribution of tau and its phosphorylated form (p-tau) to α-synuclein-induced pathology and neuronal dysfunction remains controversial. We have assessed the effects of NAP (davunetide), an eight-amino acid peptide that decreases tau hyperphosphorylation, in mice overexpressing wild-type human α-synuclein (Thy1-aSyn mice), a model that recapitulates aspects of PD. We found that the p-tau/tau level increased in a subcortical tissue block that includes the striatum and brain stem, and in the cerebellum of the Thy1-aSyn mice compared to nontransgenic controls. Intermittent intranasal NAP administration at 2 μg/mouse per day, 5 days a week, for 24 weeks, starting at 4 weeks of age, significantly decreased the ratio of p-tau/tau levels in the subcortical region while a higher dose of 15 μg/mouse per day induced a decrease in p-tau/tau levels in the cerebellum. Both NAP doses reduced hyperactivity, improved habituation to a novel environment, and reduced olfactory deficits in the Thy1-aSyn mice, but neither dose improved the severe deficits of motor coordination observed on the challenging beam and pole, contrasting with previous data obtained with continuous daily administration of the drug. The data reveal novel effects of NAP on brain p-tau/tau and behavioral outcomes in this model of synucleinopathy and suggest that sustained exposure to NAP may be necessary for maximal benefits. PMID:25505609

  14. Napping-Ultra Flash Profile as a Tool for Category Identification and Subsequent Model System Formulation of Caramel Corn Products.

    PubMed

    Mayhew, Emily; Schmidt, Shelly; Lee, Soo-Yeun

    2016-07-01

    In a novel approach to formulation, the flash descriptive profiling technique Napping-Ultra Flash Profile (Napping-UFP) was used to characterize a wide range of commercial caramel corn products. The objectives were to identify product categories, develop model systems based on product categories, and correlate analytical parameters with sensory terms generated through the Napping-UFP exercise. In one 2 h session, 12 panelists participated in 4 Napping-UFP exercises, describing and grouping, on a 43×56 cm paper sheet, 12 commercial caramel corn samples by degree of similarity, globally and in terms of aroma-by-mouth, texture, and taste. The coordinates of each sample's placement on the paper sheet and descriptive terms generated by the panelists were used to conduct Multiple Factor Analysis (MFA) and hierarchical clustering of the samples. Strong trends in the clustering of samples across the 4 Napping-UFP exercises resulted in the determination of 3 overarching types of commercial caramel corn: "small-scale dark" (typified by burnt, rich caramel corn), "large-scale light" (typified by light and buttery caramel corn), and "large-scale dark" (typified by sweet and molasses-like caramel corn). Representative samples that best exemplified the properties of each category were used as guides in the formulation of 3 model systems that represent the spread of commercial caramel corn products. Analytical testing of the commercial products, including aw measurement, moisture content determination, and thermal characterization via differential scanning calorimetry, were conducted and results related to sensory descriptors using Spearman's correlation. PMID:27249670

  15. Morning REM Sleep Naps Facilitate Broad Access to Emotional Semantic Networks

    PubMed Central

    Carr, Michelle; Nielsen, Tore

    2015-01-01

    Study Objectives: The goals of the study were to assess semantic priming to emotion and nonemotion cue words using a novel measure of associational breadth for participants who either took rapid eye movement (REM) or nonrapid eye movement (NREM) naps or who remained awake, and to assess the relation of priming to REM sleep consolidation and REM sleep inertia effects. Design: The associational breadth task was applied in both a priming condition, where cue words were signaled to be memorized prior to sleep (primed), and a nonpriming condition, where cue words were not memorized (nonprimed). Cue words were either emotional (positive, negative) or nonemotional. Participants were randomly assigned to either an awake (WAKE) or a sleep condition, which was subsequently split into NREM or REM groups depending on stage at awakening. Setting: Hospital-based sleep laboratory. Participants: Fifty-eight healthy participants (22 male) ages 18 to 35 y (mean age = 23.3 ± 4.08 y). Measurements and Results: The REM group scored higher than the NREM or WAKE groups on primed, but not nonprimed emotional cue words; the effect was stronger for positive than for negative cue words. However, REM time and percent correlated negatively with degree of emotional priming. Priming occurred for REM awakenings but not for NREM awakenings, even when the latter sleep episodes contained some REM sleep. Conclusions: Associational breadth may be selectively consolidated during REM sleep for stimuli that have been tagged as important for future memory retrieval. That priming decreased with REM time and was higher only for REM sleep awakenings is consistent with two explanatory REM sleep processes: REM sleep consolidation serving emotional downregulation and REM sleep inertia. Citation: Carr M, Nielsen T. Morning REM sleep naps facilitate broad access to emotional semantic networks. SLEEP 2015;38(3):433–443. PMID:25409100

  16. Apollo 11 preflight press conference

    NASA Technical Reports Server (NTRS)

    1969-01-01

    The three prime crewmen of the Apollo 11 lunar landing mission participate in a pre-flight press conference in the bldg 1 auditorium on July 5, 1969. Left to right, are Astronauts Neil A. Armstrong, commander; Edwin E. Aldrin Jr., lunar module pilot; and Michael Collins, command module pilot. The box-like enclosure surrounding the three astronauts was part of elaborate precautions in effect to reduce the possibility of exposing the crewmen to infectious disease in the preflight period.

  17. The Burger Court and the Press.

    ERIC Educational Resources Information Center

    Higdon, Philip R.

    This report discusses recent cases involving freedom of the press that have been heard before the Burger court of the United States Supreme Court. The report discerns a trend toward treating the press like an ordinary citizen; this is a reversal of the view of the Warren court that the First Amendment creates special rights for the press so that…

  18. 28 CFR 540.64 - Press pools.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 28 Judicial Administration 2 2011-07-01 2011-07-01 false Press pools. 540.64 Section 540.64... PERSONS IN THE COMMUNITY Contact With News Media § 540.64 Press pools. (a) The Warden may establish a press pool whenever he or she determines that the frequency of requests for interviews and...

  19. 28 CFR 540.64 - Press pools.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 28 Judicial Administration 2 2014-07-01 2014-07-01 false Press pools. 540.64 Section 540.64... PERSONS IN THE COMMUNITY Contact With News Media § 540.64 Press pools. (a) The Warden may establish a press pool whenever he or she determines that the frequency of requests for interviews and...

  20. 28 CFR 540.64 - Press pools.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 28 Judicial Administration 2 2013-07-01 2013-07-01 false Press pools. 540.64 Section 540.64... PERSONS IN THE COMMUNITY Contact With News Media § 540.64 Press pools. (a) The Warden may establish a press pool whenever he or she determines that the frequency of requests for interviews and...

  1. 28 CFR 540.64 - Press pools.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 28 Judicial Administration 2 2012-07-01 2012-07-01 false Press pools. 540.64 Section 540.64... PERSONS IN THE COMMUNITY Contact With News Media § 540.64 Press pools. (a) The Warden may establish a press pool whenever he or she determines that the frequency of requests for interviews and...

  2. Attention that Indicators Receive in the Press

    ERIC Educational Resources Information Center

    Hendriks, Maria; Barzano, Giovanna; Brumana, Emanuela; Cremonesi, Claudia

    2004-01-01

    With the release of each edition of Education at a Glance, the Office for Economic Co-operation and Development (OECD) prepares a press briefing to be used for the international press release and which individual countries in preparing their national press releases can also use. Similarly, the European Union prepares a summary, not for use at the…

  3. 28 CFR 540.64 - Press pools.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Press pools. 540.64 Section 540.64... PERSONS IN THE COMMUNITY Contact With News Media § 540.64 Press pools. (a) The Warden may establish a press pool whenever he or she determines that the frequency of requests for interviews and...

  4. USAF Academy Center for Space Situational Awareness

    NASA Astrophysics Data System (ADS)

    Dearborn, M.; Chun, F.; Liu, J.; Tippets, R.

    2011-09-01

    Since the days of Sputnik, the Air Force has maintained the surveillance of space and a position catalog of objects that can be tracked by primarily ground-based radars and optical systems. Recent events in space such as the test of the Chinese anti-satellite weapon in 2007 and the collision between an Iridium and Russian Cosmo satellite have demonstrated the great need to have a more comprehensive awareness of the situation in space. Hence space situational awareness (SSA) has become an increasingly important mission to the Air Force and to the security of the United States. To help meet the need for future leaders knowledgeable about SSA, the Air Force Academy formally stood up the Center for Space Situational Awareness (CSSAR). The goal of the CSSAR is to provide a unique combination of educational operational experience as well as a world-class research capability for hands-on education in SSA. In order to meet this goal, the CSSAR is implementing an array of sensors, operations center, and associated software, and analysis tools. For example we have radar receivers for bi-static returns from the VHF space fence, a network of small aperture telescopes, AFSPC astro standards software, and Joint Mission System software. This paper focuses on the observational capabilities of our telescopes. In general, the preferable method for characterizing a satellite is to obtain a high-resolution image. However, high-resolution images from groundbased telescopes are only achievable if the satellite is large and close in range. Thus small satellites in low-earth orbits and large satellites in geosynchronous orbits are essentially unresolved in the focal plane of a ground-based telescope. Building ever larger telescopes capable of tracking fast enough for satellites at high resolution requires tremendous resources and funding. Cost is one of the reasons we decided to develop a network of small, commercially available telescopes spatially diverse and networked together. We call

  5. Evolution of a Planetary System. SETI Academy Planet Project.

    ERIC Educational Resources Information Center

    Search for Extraterrestrial Intelligence Inst., Mountain View, CA.

    The SETI Academy Planet Project provides an exciting, informative, and creative series of activities for elementary students (grades 5-6) in these activities each student plays the role of a cadet at the SETI Academy, a fictitious institution. This unit examines the evolution of stars and planets which is an important aspect of the search for…

  6. Boot Camp for Education CEOs: The Broad Foundation Superintendents Academy

    ERIC Educational Resources Information Center

    Jehlen, Alain

    2012-01-01

    The Broad Foundation Superintendents Academy is the most prominent and most controversial training institute for school chiefs. The Academy is the flagship program of the Eli and Edythe Broad Foundation, the smallest of a triumvirate of corporate foundations that are at the heart of the billionaire campaign to remake public education in the image…

  7. A Program Evaluation of a Leadership Academy for School Principals

    ERIC Educational Resources Information Center

    Wagner, Kristi E.

    2014-01-01

    This program evaluation focused on mid-range outcomes of a leadership academy for school principals. The mixed-methods evaluation included interviews, principals' instructional observation database, and teacher surveys. The Principal Academy program was designed to build principals' knowledge of high-yield instructional strategies (Hattie, 2009),…

  8. Ethos and Vision Realization in Sponsored Academy Schools

    ERIC Educational Resources Information Center

    Gibson, Mark T.

    2015-01-01

    This article investigates the realization of ethos and vision in the early stages of sponsored academy schools in England. It is a qualitative nested case study of ten academies. Nineteen key actors were interviewed, including principals and sponsor representatives. The nests were organized by sponsor type. Key themes are discussed within the…

  9. Academies and Maintained Schools: What Do We Know? Election Factsheet

    ERIC Educational Resources Information Center

    Gee, Geoff; Worth, Jack; Sims, David

    2015-01-01

    This election factsheet highlights the following points: (1) Academies receive their funding directly from the government, rather than through local authorities like other state funded schools; (2) There are two types: converter academies (those previously with "good" or "outstanding" Ofsted grades that have converted to…

  10. Academy of READING®. What Works Clearinghouse Intervention Report

    ERIC Educational Resources Information Center

    What Works Clearinghouse, 2014

    2014-01-01

    "Academy of READING"® is an online program that aims to improve students' reading skills using a structured and sequential approach to learning in five core areas--phonemic awareness, phonics, fluency, vocabulary, and comprehension. The What Works Clearinghouse (WWC) identified 38 studies of "Academy of READING"® for…

  11. Employer Involvement in Career Academies: Old Model Sparks New Involvement.

    ERIC Educational Resources Information Center

    Weil, Lindsay

    More employers have mobilized to support career academies. They say that in addition to improving student engagement in school, academies help to strengthen relationships among business leaders, educators, and civic leaders; prevent high risk students from dropping out; and expand their pipeline of qualified workers. Academic research has helped…

  12. Career Academies. What Works Clearinghouse Intervention Report. Updated September 2015

    ERIC Educational Resources Information Center

    What Works Clearinghouse, 2015

    2015-01-01

    "Career Academies" is a dropout prevention strategy for youth considered most at risk of dropping out of high school. Students in the program take both career-related and academic courses and acquire work experience through partnerships with local employers. "Career Academies" integrate rigorous academic curricula with career…

  13. Teachers' Experiences with the Transition to a Career Academy

    ERIC Educational Resources Information Center

    Spurlock, Charlene Denise

    2010-01-01

    Career academies, schools within schools that concentrate on career fields, require the intentional efforts of teachers working collaboratively and sharing best practices to increase students' achievement and employability. Little is known of the perceptions of career academies' teachers, however, as they attempt to make changes in practice. The…

  14. Academies in Action: Case Studies from Camden and Pimlico, 2007

    ERIC Educational Resources Information Center

    Benn, Melissa

    2008-01-01

    Both main UK political parties lend enthusiastic public support to academies, in the name of supporting the nation's poorest pupils. But Gordon Brown's Labour is, in reality, unsure about this undemocratic model while the Tories may well in the future exploit academy "independence" for retrograde ends. Two contemporary case studies from London, in…

  15. Parents in the Admission Process: A Service Academy's Perspective.

    ERIC Educational Resources Information Center

    Combs, Thomas D., Jr.

    1986-01-01

    Service academies have found that parental influence is a significant factor in the application and selection processes. Project Outreach of the Coast Guard Academy, a parent-to-parent contact using volunteers supervised by the Admissions Office, represents a way of showing concern regarding each student's uniqueness and of constructively…

  16. Math, Science Academies Favored to Challenge Top-Tier Students

    ERIC Educational Resources Information Center

    Cavanagh, Sean

    2006-01-01

    This article focuses on the specialized academies in math and science, aimed at serving students for whom even a rigorous high school lineup of college-preparatory and honors courses is not enough. Math and science academies have been a fixture in states and school districts for decades, but they are drawing renewed interest as educators and…

  17. Academies in Context: Politics, Business and Philanthropy and Heterarchical Governance

    ERIC Educational Resources Information Center

    Ball, Stephen J.

    2009-01-01

    The English Academies programme has become one of the most controversial aspects of the New Labour strategy for education and public sector reform. And in many ways, given the significance of the programme, that controversy is understandable and appropriate. This is particularly so because, as the author argues here, Academies are indicative of…

  18. Visible Leading: Principal Academy Connects and Empowers Principals

    ERIC Educational Resources Information Center

    Hindman, Jennifer; Rozzelle, Jan; Ball, Rachel; Fahey, John

    2015-01-01

    The School-University Research Network (SURN) Principal Academy at the College of William & Mary in Williamsburg, Virginia, has a mission to build a leadership development program that increases principals' instructional knowledge and develops mentor principals to sustain the program. The academy is designed to connect and empower principals…

  19. Vocational Education in the 19th Century American Academy.

    ERIC Educational Resources Information Center

    Law, Gordon F.

    The phrase "all things useful and all things ornamental," coined by Benjamin Franklin, describes the stated mission of most of the approximately 6,000 educational academies flourishing in America in the mid-19th century. Built upon the roots of Latin grammar schools, the academies evolved to include courses in many areas, from classical studies to…

  20. Diversity of Service Academy Entrants and Graduates. Monograph

    ERIC Educational Resources Information Center

    Kirby, Sheila Nataraj; Thie, Harry J.; Naftel, Scott; Adelson, Marisa

    2010-01-01

    In the wake of concern about the diversity of cadets/midshipmen selected by the service academies, Congress requested that the Secretary of Defense conduct a comprehensive assessment of the recruiting efforts, admissions policies, graduation rates, and career success rates of entrants and graduates at the United States Military Academy (USMA), the…

  1. Implementing Career Academies Schoolwide: 2001-2002 Developments, Promising Practices.

    ERIC Educational Resources Information Center

    Stern, David; Dayton, Charles; Lenz, Robert; Tidyman, Susan

    This document, which is based on the findings of case studies of how four high schools from across the country have successfully implemented the schoolwide career academy model, presents recent developments and best practices in schoolwide career academies. The document consists of a brief introduction describing the case studies and one chapter…

  2. OnTheMove Academy 2009 Organizers' Message

    NASA Astrophysics Data System (ADS)

    Spyns, Peter; Schanzenberger, Anja

    We are very happy to re-establish the tradition of organizing what is now called the OTM Academy, the workshop for coaching PhD students with promising work. The term "academy," originating from Greek antiquity, implies a strong mark of quality and excellence that is upheld and promoted by its members.

  3. Predictors of Student Enrollment Patterns in High School Career Academies

    ERIC Educational Resources Information Center

    Cox, E. Daniel

    2013-01-01

    The purpose of this study was to describe participation patterns at the district level of students enrolled in career academies and determine whether participation in career academies is a function of demographic and/or prior learning experience and prior performance variables. Ex-post facto data was used to determine six-year enrollment trends.…

  4. Academic Integrity at the United States Air Force Academy

    ERIC Educational Resources Information Center

    Derby, LeAnn

    2006-01-01

    In troubled times, where threats to honor abound, it is essential that people support students who may have been enculturated in social dishonesty. The United States Air Force Academy (USAFA) has worked hard to put in place a number of supports to help cadets to grow beyond social norms where dishonesty may be tolerated. The academy seeks to…

  5. Another School Is Possible: Developing Positive Alternatives to Academies

    ERIC Educational Resources Information Center

    Flack, Peter

    2010-01-01

    Low-attaining schools have been targeted by government for closure and transformation into academies. This article argues that opposition to academies is necessary but not sufficient. It is vital to do more than simply defend the status quo. In the city of Leicester an alternative vision for high-quality education, local authority led and grounded…

  6. The Academy Promotes, Unifies, and Evaluates Doctoral Education in Kinesiology

    ERIC Educational Resources Information Center

    Thomas, Jerry R.; Clark, Jane E.; Feltz, Deborah L.; Kretchmar, R. Scott; Morrow, James R., Jr.; Reeve, T. Gilmour; Wade, Michael G.

    2007-01-01

    This paper provides a description and documentation of two significant events in the history of our field: (1) the development of our field and the doctoral program review process and outcome by the American Academy of Kinesiology and Physical Education; and (2) the process by which the Academy successfully had "kinesiology" included as a…

  7. Science, Engineering, Mathematics and Aerospace Academy

    NASA Technical Reports Server (NTRS)

    1996-01-01

    The Science, Engineering, Mathematics and Aerospace Academy (SEMAA) was established in September, 1993, by Cuyahoga Community College and the NASA Lewis Research Center. Funding for SEMAA was provided by NASA Headquarters' Office of Equal Employment Opportunities. SEMAA brought together five preexisting youth programs at Cuyahoga Community College. All the programs shared the common goals of 1) Increasing the participation of underrepresented/underserved groups in science, mathematics and engineering and technology careers. 2) Increasing "success" rates of all students interested in science and mathematics. 3) Developing partnerships to recognize and support students interested in these fields. 4) Supporting continued success of highly successful students. The framework for each preexisting program allowed SEMAA to have a student population ranging from kindergarten through the twelfth-grade. This connectivness was the foundation for the many decisions which would make SEMAA a truly innovative program.

  8. Science, Engineering, Mathematics and Aerospace Academy

    NASA Technical Reports Server (NTRS)

    1997-01-01

    This is an annual report on the Science, Engineering, Mathematics, and Aerospace Academy (SEMAA), which is run as a collaborative effort of NASA Lewis Research Center, and Cuyahgoga Community College. The purpose of SEMA is to increase the percentage of African Americans, and Hispanics in the fields of science and technology. The SEMAA program reaches from kindergarden, to grade 12, involving the family of under-served minorities in the education of the children. The year being reported (i.e., 1996-1997) saw considerable achievement. The program served over 1,939 students, and 120 parents were involved in various seminars. The report goes on to review the program and its implementation for each grade level. It also summarizes the participation, by gender and ethnicity.

  9. The CORD Academy for scholarship in education in emergency medicine.

    PubMed

    Lamantia, Joseph; Kuhn, Gloria J; Searle, Nancy S

    2010-10-01

    In 2010 the Council of Emergency Medicine Residency Directors (CORD) established an Academy for Scholarship in Education in Emergency Medicine to define, promote, recognize, and reward excellence in education, education research, and education leadership in emergency medicine. In this article we describe the mission and aims of the Academy. Academies for medical educators are widespread in medical schools today and have produced many benefits both for faculty and for educational programs. Little effort, however, has been devoted to such a model in graduate medical education specialty societies. While CORD and other emergency medicine organizations have developed numerous initiatives to advance excellence in education, we believe that this effort will be accelerated if housed in the form of an Academy that emphasizes scholarship in teaching and other education activities. The CORD Academy for Scholarship in Education in Emergency Medicine is a new model for promoting excellence in education in graduate medical education specialty societies.

  10. [The contribution of the Military Medical Academy to space exploration].

    PubMed

    Belevitin, A B; Tsygan, V N; Blaginin, A A; Kaltygin, M V

    2011-04-01

    The article examines the contribution of the Military Medical Academy as an educational, research and medical institutions in the establishment and development of the national Russian manned spaceflight. Lists the names of the Academy's scientists, working in laboratories and in the Cosmonaut Training Center. In 1958 the academy was formed Department of Aviation Medicine from the research laboratories of aviation medicine, psychophysiology, and encephalography, a division of pressure chambers and furnaces. Direct contribution to the preparation of the first manned space flight made by graduates of the academy, E.A. Karpov (the first chief of Cosmonauts Training Center. Yuri Gagarin) and I.A. Kolosov. Over the half century history of the Russian Space Military Medical Academy, prepared and sent to the CPC Gagarin more than 110 of its graduates.

  11. [The contribution of the Military Medical Academy to space exploration].

    PubMed

    Belevitin, A B; Tsygan, V N; Blaginin, A A; Kaltygin, M V

    2011-04-01

    The article examines the contribution of the Military Medical Academy as an educational, research and medical institutions in the establishment and development of the national Russian manned spaceflight. Lists the names of the Academy's scientists, working in laboratories and in the Cosmonaut Training Center. In 1958 the academy was formed Department of Aviation Medicine from the research laboratories of aviation medicine, psychophysiology, and encephalography, a division of pressure chambers and furnaces. Direct contribution to the preparation of the first manned space flight made by graduates of the academy, E.A. Karpov (the first chief of Cosmonauts Training Center. Yuri Gagarin) and I.A. Kolosov. Over the half century history of the Russian Space Military Medical Academy, prepared and sent to the CPC Gagarin more than 110 of its graduates. PMID:21770320

  12. 76 FR 9760 - Presidential Academies for Teaching of American History and Civics; Office of Innovation and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-22

    ... Presidential Academies for Teaching of American History and Civics; Office of Innovation and Improvement; Overview Information; Presidential Academies for Teaching of American History and Civics; Notice Inviting... program supports the establishment of Presidential Academies for Teaching of American History and...

  13. National Academy of Sciences Recommends Continued Support of ALMA Project

    NASA Astrophysics Data System (ADS)

    2000-05-01

    A distinguished panel of scientists today announced their support for the continued funding of the Atacama Large Millimeter Array (ALMA) Project at a press conference given by the National Academy of Sciences. The ALMA Project is an international partnership between U.S. and European astronomy organizations to build a complete imaging telescope that will produce astronomical images at millimeter and submillimeter wavelengths. The U.S. partner is the National Science Foundation, through Associated Universities, Inc., (AUI), led by Dr. Riccardo Giacconi, and the National Radio Astronomy Observatory (NRAO). "We are delighted at this show of continued support from our peers in the scientific community," said Dr. Robert Brown, ALMA U.S. Project Director and Deputy Director of NRAO. "The endorsement adds momentum to the recent strides we've made toward the building of this important telescope." In 1998, the National Research Council, the working arm of the National Academy of Sciences, charged the Astronomy and Astrophysics Survey Committee to "survey the field of space- and ground-based astronomy and astrophysics" and to "recommend priorities for the most important new initiatives of the decade 2000-2010." In a report released today, the committee wrote that it "re-affirms the recommendations of the 1991 Astronomy and Astrophysics Survey Committee by endorsing the completion of . . . the Millimeter Array (MMA, now part of the Atacama Large Millimeter Array)." In the 1991 report "The Decade of Discovery," a previous committee chose the Millimeter Array as one of the most important projects of the decade 1990-2000. Early last year, the National Science Foundation signed a Memorandum of Understanding with a consortium of European organizations that effectively merged the MMA Project with the European Large Southern Array project. The combined project was christened the Atacama Large Millimeter Array. ALMA, expected to consist of 64 antennas with 12-meter diameter dishes

  14. C-Nap1 mutation affects centriole cohesion and is associated with a Seckel-like syndrome in cattle.

    PubMed

    Floriot, Sandrine; Vesque, Christine; Rodriguez, Sabrina; Bourgain-Guglielmetti, Florence; Karaiskou, Anthi; Gautier, Mathieu; Duchesne, Amandine; Barbey, Sarah; Fritz, Sébastien; Vasilescu, Alexandre; Bertaud, Maud; Moudjou, Mohammed; Halliez, Sophie; Cormier-Daire, Valérie; Hokayem, Joyce E L; Nigg, Erich A; Manciaux, Luc; Guatteo, Raphaël; Cesbron, Nora; Toutirais, Geraldine; Eggen, André; Schneider-Maunoury, Sylvie; Boichard, Didier; Sobczak-Thépot, Joelle; Schibler, Laurent

    2015-01-01

    Caprine-like Generalized Hypoplasia Syndrome (SHGC) is an autosomal-recessive disorder in Montbéliarde cattle. Affected animals present a wide range of clinical features that include the following: delayed development with low birth weight, hind limb muscular hypoplasia, caprine-like thin head and partial coat depigmentation. Here we show that SHGC is caused by a truncating mutation in the CEP250 gene that encodes the centrosomal protein C-Nap1. This mutation results in centrosome splitting, which neither affects centriole ultrastructure and duplication in dividing cells nor centriole function in cilium assembly and mitotic spindle organization. Loss of C-Nap1-mediated centriole cohesion leads to an altered cell migration phenotype. This discovery extends the range of loci that constitute the spectrum of autosomal primary recessive microcephaly (MCPH) and Seckel-like syndromes. PMID:25902731

  15. The histone chaperones Nap1 and Vps75 bind histones H3 and H4 in a tetrameric conformation.

    PubMed

    Bowman, Andrew; Ward, Richard; Wiechens, Nicola; Singh, Vijender; El-Mkami, Hassane; Norman, David George; Owen-Hughes, Tom

    2011-02-18

    Histone chaperones physically interact with histones to direct proper assembly and disassembly of nucleosomes regulating diverse nuclear processes such as DNA replication, promoter remodeling, transcription elongation, DNA damage, and histone variant exchange. Currently, the best-characterized chaperone-histone interaction is that between the ubiquitous chaperone Asf1 and a dimer of H3 and H4. Nucleosome assembly proteins (Nap proteins) represent a distinct class of histone chaperone. Using pulsed electron double resonance (PELDOR) measurements and protein crosslinking, we show that two members of this class, Nap1 and Vps75, bind histones in the tetrameric conformation also observed when they are sequestered within the nucleosome. Furthermore, H3 and H4 trapped in their tetrameric state can be used as substrates in nucleosome assembly and chaperone-mediated lysine acetylation. This alternate mode of histone interaction provides a potential means of maintaining the integrity of the histone tetramer during cycles of nucleosome reassembly.

  16. C-Nap1 mutation affects centriole cohesion and is associated with a Seckel-like syndrome in cattle.

    PubMed

    Floriot, Sandrine; Vesque, Christine; Rodriguez, Sabrina; Bourgain-Guglielmetti, Florence; Karaiskou, Anthi; Gautier, Mathieu; Duchesne, Amandine; Barbey, Sarah; Fritz, Sébastien; Vasilescu, Alexandre; Bertaud, Maud; Moudjou, Mohammed; Halliez, Sophie; Cormier-Daire, Valérie; Hokayem, Joyce E L; Nigg, Erich A; Manciaux, Luc; Guatteo, Raphaël; Cesbron, Nora; Toutirais, Geraldine; Eggen, André; Schneider-Maunoury, Sylvie; Boichard, Didier; Sobczak-Thépot, Joelle; Schibler, Laurent

    2015-04-23

    Caprine-like Generalized Hypoplasia Syndrome (SHGC) is an autosomal-recessive disorder in Montbéliarde cattle. Affected animals present a wide range of clinical features that include the following: delayed development with low birth weight, hind limb muscular hypoplasia, caprine-like thin head and partial coat depigmentation. Here we show that SHGC is caused by a truncating mutation in the CEP250 gene that encodes the centrosomal protein C-Nap1. This mutation results in centrosome splitting, which neither affects centriole ultrastructure and duplication in dividing cells nor centriole function in cilium assembly and mitotic spindle organization. Loss of C-Nap1-mediated centriole cohesion leads to an altered cell migration phenotype. This discovery extends the range of loci that constitute the spectrum of autosomal primary recessive microcephaly (MCPH) and Seckel-like syndromes.

  17. The Molybdate-Responsive Escherichia coli ModE Transcriptional Regulator Coordinates Periplasmic Nitrate Reductase (napFDAGHBC) Operon Expression with Nitrate and Molybdate Availability

    PubMed Central

    McNicholas, Paul M.; Gunsalus, Robert P.

    2002-01-01

    Expression of the Escherichia coli napFDAGHBC operon (also known as aeg46.5), which encodes the periplasmic molybdoenzyme for nitrate reduction, is increased in response to anaerobiosis and further stimulated by the addition of nitrate or to a lesser extent by nitrite to the cell culture medium. These changes are mediated by the transcription factors Fnr and NarP, respectively. Utilizing a napF-lacZ operon fusion, we demonstrate that napF gene expression is impaired in strain defective for the molybdate-responsive ModE transcription factor. This control abrogates nitrate- or nitrite-dependent induction during anaerobiosis. Gel shift and DNase I footprinting analyses establish that ModE binds to the napF promoter with an apparent Kd of about 35 nM at a position centered at −133.5 relative to the start of napF transcription. Although the ModE binding site sequence is similar to other E. coli ModE binding sites, the location is atypical, because it is not centered near the start of transcription. Introduction of point mutations in the ModE recognition site severely reduced or abolished ModE binding in vitro and conferred a modE phenotype (i.e., loss of molybdate-responsive gene expression) in vivo. In contrast, deletion of the upstream ModE region site rendered napF expression independent of modE. These findings indicate the involvement of an additional transcription factor to help coordinate nitrate- and molybdate-dependent napF expression by the Fnr, NarP, NarL, and ModE proteins. The upstream ModE regulatory site functions to override nitrate control of napF gene expression when the essential enzyme component, molybdate, is limiting in the cell environment. PMID:12029041

  18. The Periplasmic Nitrate Reductase NapABC Supports Luminal Growth of Salmonella enterica Serovar Typhimurium during Colitis

    PubMed Central

    Lopez, Christopher A.; Rivera-Chávez, Fabian; Byndloss, Mariana X.

    2015-01-01

    The food-borne pathogen Salmonella enterica serovar Typhimurium benefits from acute inflammation in part by using host-derived nitrate to respire anaerobically and compete successfully with the commensal microbes during growth in the intestinal lumen. The S. Typhimurium genome contains three nitrate reductases, encoded by the narGHI, narZYV, and napABC genes. Work on homologous genes present in Escherichia coli suggests that nitrate reductase A, encoded by the narGHI genes, is the main enzyme promoting growth on nitrate as an electron acceptor in anaerobic environments. Using a mouse colitis model, we found, surprisingly, that S. Typhimurium strains with defects in either nitrate reductase A (narG mutant) or the regulator inducing its transcription in the presence of high concentrations of nitrate (narL mutant) exhibited growth comparable to that of wild-type S. Typhimurium. In contrast, a strain lacking a functional periplasmic nitrate reductase (napA mutant) exhibited a marked growth defect in the lumen of the colon. In E. coli, the napABC genes are transcribed maximally under anaerobic growth conditions in the presence of low nitrate concentrations. Inactivation of narP, encoding a response regulator that activates napABC transcription in response to low nitrate concentrations, significantly reduced the growth of S. Typhimurium in the gut lumen. Cecal nitrate measurements suggested that the murine cecum is a nitrate-limited environment. Collectively, our results suggest that S. Typhimurium uses the periplasmic nitrate reductase to support its growth on the low nitrate concentrations encountered in the gut, a strategy that may be shared with other enteric pathogens. PMID:26099579

  19. Histone Chaperone Nap1 Is a Major Regulator of Histone H2A-H2B Dynamics at the Inducible GAL Locus

    PubMed Central

    Chen, Xu; D'Arcy, Sheena; Radebaugh, Catherine A.; Krzizike, Daniel D.; Giebler, Holli A.; Huang, Liangquan; Nyborg, Jennifer K.; Luger, Karolin

    2016-01-01

    Histone chaperones, like nucleosome assembly protein 1 (Nap1), play a critical role in the maintenance of chromatin architecture. Here, we use the GAL locus in Saccharomyces cerevisiae to investigate the influence of Nap1 on chromatin structure and histone dynamics during distinct transcriptional states. When the GAL locus is not expressed, cells lacking Nap1 show an accumulation of histone H2A-H2B but not histone H3-H4 at this locus. Excess H2A-H2B interacts with the linker DNA between nucleosomes, and the interaction is independent of the inherent DNA-binding affinity of H2A-H2B for these particular sequences as measured in vitro. When the GAL locus is transcribed, excess H2A-H2B is reversed, and levels of all chromatin-bound histones are depleted in cells lacking Nap1. We developed an in vivo system to measure histone exchange at the GAL locus and observed considerable variability in the rate of exchange across the locus in wild-type cells. We recapitulate this variability with in vitro nucleosome reconstitutions, which suggests a contribution of DNA sequence to histone dynamics. We also find that Nap1 is required for transcription-dependent H2A-H2B exchange. Altogether, these results indicate that Nap1 is essential for maintaining proper chromatin composition and modulating the exchange of H2A-H2B in vivo. PMID:26884462

  20. Chaperone Nap1 shields histone surfaces used in a nucleosome and can put H2A-H2B in an unconventional tetrameric form.

    PubMed

    D'Arcy, Sheena; Martin, Kyle W; Panchenko, Tanya; Chen, Xu; Bergeron, Serge; Stargell, Laurie A; Black, Ben E; Luger, Karolin

    2013-09-12

    The histone H2A-H2B heterodimer is an integral component of the nucleosome. The cellular localization and deposition of H2A-H2B into chromatin is regulated by numerous factors, including histone chaperones such as nucleosome assembly protein 1 (Nap1). We use hydrogen-deuterium exchange coupled to mass spectrometry to characterize H2A-H2B and Nap1. Unexpectedly, we find that at low ionic strength, the α helices in H2A-H2B are frequently sampling partially disordered conformations and that binding to Nap1 reduces this conformational sampling. We identify the interaction surface between H2A-H2B and Nap1 and confirm its relevance both in vitro and in vivo. We show that two copies of H2A-H2B bound to a Nap1 homodimer form a tetramer with contacts between H2B chains similar to those in the four-helix bundle structural motif. The organization of the complex reveals that Nap1 competes with histone-DNA and interhistone interactions observed in the nucleosome, thereby regulating the availability of histones for chromatin assembly. PMID:23973327

  1. Histone Chaperone Nap1 Is a Major Regulator of Histone H2A-H2B Dynamics at the Inducible GAL Locus.

    PubMed

    Chen, Xu; D'Arcy, Sheena; Radebaugh, Catherine A; Krzizike, Daniel D; Giebler, Holli A; Huang, Liangquan; Nyborg, Jennifer K; Luger, Karolin; Stargell, Laurie A

    2016-04-01

    Histone chaperones, like nucleosome assembly protein 1 (Nap1), play a critical role in the maintenance of chromatin architecture. Here, we use the GAL locus in Saccharomyces cerevisiae to investigate the influence of Nap1 on chromatin structure and histone dynamics during distinct transcriptional states. When the GAL locus is not expressed, cells lacking Nap1 show an accumulation of histone H2A-H2B but not histone H3-H4 at this locus. Excess H2A-H2B interacts with the linker DNA between nucleosomes, and the interaction is independent of the inherent DNA-binding affinity of H2A-H2B for these particular sequences as measured in vitro When the GAL locus is transcribed, excess H2A-H2B is reversed, and levels of all chromatin-bound histones are depleted in cells lacking Nap1. We developed an in vivo system to measure histone exchange at the GAL locus and observed considerable variability in the rate of exchange across the locus in wild-type cells. We recapitulate this variability with in vitro nucleosome reconstitutions, which suggests a contribution of DNA sequence to histone dynamics. We also find that Nap1 is required for transcription-dependent H2A-H2B exchange. Altogether, these results indicate that Nap1 is essential for maintaining proper chromatin composition and modulating the exchange of H2A-H2B in vivo. PMID:26884462

  2. Chaperone Nap1 shields histone surfaces used in a nucleosome and can put H2A-H2B in an unconventional tetrameric form

    PubMed Central

    D’Arcy, Sheena; Martin, Kyle W.; Panchenko, Tanya; Chen, Xu; Bergeron, Serge; Stargell, Laurie A.; Black, Ben E.; Luger, Karolin

    2013-01-01

    Summary The histone H2A-H2B heterodimer is an integral component of the nucleosome. The cellular localization and deposition of H2A-H2B into chromatin is regulated by numerous factors including histone chaperones such as Nucleosome Assembly Protein 1 (Nap1). We use hydrogen-deuterium exchange coupled to mass spectrometry to characterize H2A-H2B and Nap1. Unexpectedly, we find that at low ionic strength the α-helices in H2A-H2B are frequently sampling partially disordered conformations, and that binding to Nap1 reduces this conformational sampling. We identify the interaction surface between H2A-H2B and Nap1, and confirm its relevance both in vitro and in vivo. We show that two copies of H2A-H2B bound to a Nap1 homodimer form a tetramer with contacts between H2B chains similar to those in the four-helix bundle structural motif. The organization of the complex reveals that Nap1 competes with histone-DNA and inter-histone interactions observed in the nucleosome, thereby regulating the availability of histones for chromatin assembly. PMID:23973327

  3. Nap1 stimulates homologous recombination by RAD51 and RAD54 in higher-ordered chromatin containing histone H1.

    PubMed

    Machida, Shinichi; Takaku, Motoki; Ikura, Masae; Sun, Jiying; Suzuki, Hidekazu; Kobayashi, Wataru; Kinomura, Aiko; Osakabe, Akihisa; Tachiwana, Hiroaki; Horikoshi, Yasunori; Fukuto, Atsuhiko; Matsuda, Ryo; Ura, Kiyoe; Tashiro, Satoshi; Ikura, Tsuyoshi; Kurumizaka, Hitoshi

    2014-01-01

    Homologous recombination plays essential roles in mitotic DNA double strand break (DSB) repair and meiotic genetic recombination. In eukaryotes, RAD51 promotes the central homologous-pairing step during homologous recombination, but is not sufficient to overcome the reaction barrier imposed by nucleosomes. RAD54, a member of the ATP-dependent nucleosome remodeling factor family, is required to promote the RAD51-mediated homologous pairing in nucleosomal DNA. In higher eukaryotes, most nucleosomes form higher-ordered chromatin containing the linker histone H1. However, the mechanism by which RAD51/RAD54-mediated homologous pairing occurs in higher-ordered chromatin has not been elucidated. In this study, we found that a histone chaperone, Nap1, accumulates on DSB sites in human cells, and DSB repair is substantially decreased in Nap1-knockdown cells. We determined that Nap1 binds to RAD54, enhances the RAD54-mediated nucleosome remodeling by evicting histone H1, and eventually stimulates the RAD51-mediated homologous pairing in higher-ordered chromatin containing histone H1. PMID:24798879

  4. Van Allen Probes Mission Space Academy: Educating middle school students about Earth's mysterious radiation belts

    NASA Astrophysics Data System (ADS)

    Butler, L.; Turney, D.; Matiella Novak, A.; Smith, D.; Simon, M.

    2013-12-01

    How's the weather in space? Why on Earth did NASA send two satellites above Earth to study radiation belts and space weather? To learn the answer to questions about NASA's Van Allen Probes mission, 450 students and their teachers from Maryland middle schools attended Space Academy events highlighting the Van Allen Probes mission. Sponsored by the Applied Physics Laboratory (APL) and Discovery Education, the events are held at the APL campus in Laurel, MD. Space Academies take students and teachers on behind-the-scenes exploration of how spacecraft are built, what they are designed to study, and introduces them to the many professionals that work together to create some of NASA's most exciting projects. Moderated by a public relations representative in the format of an official NASA press conference, the daylong event includes a student press conference with students as reporters and mission experts as panelists. Lunch with mission team members gives students a chance to ask more questions. After lunch, students don souvenir clean room suits, enjoy interactive science demonstrations, and tour APL facilities where the Van Allen Probes were built and tested before launch. Students may even have an opportunity to peek inside a clean room to view spacecraft being assembled. Prior to the event, teachers are provided with classroom activities, lesson plans, and videos developed by APL and Discovery Education to help prepare students for the featured mission. The activities are aligned to National Science Education Standards and appropriate for use in the classroom. Following their visit, student journalists are encouraged to write a short article about their field trip; selections are posted on the Space Academy web site. Designed to engage, inspire, and influence attitudes about space science and STEM careers, Space Academies provide an opportunity to attract underserved populations and emphasize that space science is for everyone. Exposing students to a diverse group of

  5. A NAP-Family Histone Chaperone Functions in Abiotic Stress Response and Adaptation1[OPEN

    PubMed Central

    Pareek, Ashwani; Singla-Pareek, Sneh Lata

    2016-01-01

    Modulation of gene expression is one of the most significant molecular mechanisms of abiotic stress response in plants. Via altering DNA accessibility, histone chaperones affect the transcriptional competence of genomic loci. However, in contrast to other factors affecting chromatin dynamics, the role of plant histone chaperones in abiotic stress response and adaptation remains elusive. Here, we studied the physiological function of a stress-responsive putative rice (Oryza sativa) histone chaperone of the NAP superfamily: OsNAPL6. We show that OsNAPL6 is a nuclear-localized H3/H4 histone chaperone capable of assembling a nucleosome-like structure. Utilizing overexpression and knockdown approaches, we found a positive correlation between OsNAPL6 expression levels and adaptation to multiple abiotic stresses. Results of comparative transcriptome profiling and promoter-recruitment studies indicate that OsNAPL6 functions during stress response via modulation of expression of various genes involved in diverse functions. For instance, we show that OsNAPL6 is recruited to OsRad51 promoter, activating its expression and leading to more efficient DNA repair and abrogation of programmed cell death under salinity and genotoxic stress conditions. These results suggest that the histone chaperone OsNAPL6 may serve a regulatory role in abiotic stress physiology possibly via modulating nucleosome dynamics at various stress-associated genomic loci. Taken together, our findings establish a hitherto unknown link between histone chaperones and abiotic stress response in plants. PMID:27342307

  6. NASA/MSFC Large Stretch Press Study

    NASA Technical Reports Server (NTRS)

    Choate, M. W.; Nealson, W. P.; Jay, G. C.; Buss, W. D.

    1985-01-01

    The purpose of this study was to: A. assess and document the advantages/disadvantages of a government agency investment in a large stretch form press on the order of 5000 tons capacity (per jaw); B. develop a procurement specification for the press; and C. provide trade study data that will permit an optimum site location. Tasks were separated into four major elements: cost study, user survey, site selection, and press design/procurement specification.

  7. [The Academy of Ideas - second edition 2014].

    PubMed

    2014-01-01

    The Academy of Ideas is an initiative of the Italian Society of Nephrology, dedicated to young people who work in nephrology. The 2014 edition wants to foster innovative ideas at different levels of maturity along the research and innovation process, through two distinct sections meant for people who present basic or applied research ideas and for people who submit proofs of concepts transferable to products or services in a relatively short time period. The proposal aims to enhance grant application skills, giving to young researchers the opportunity of collaborating with multi-disciplinary groups of professionals; help young researchers to exploit ideas arising from clinical research and showing a Technology Readiness Level that allows immediate or close in time applicability; foster the understanding of the business perspective in the nephrology sector: giving to young scientists the opportunity to have in-hand experience on challenges related to bringing to the market research results; create a network of knowledge and collaboration among young researchers to facilitate the establishment of collaborative relationships and promote the creation of new projects and publications of high scientific impact. PMID:24945044

  8. [The press and family planning].

    PubMed

    Abraham De D'ornellas, R

    1987-01-01

    The treatment in the press of family planning hinges on two fundamental factors: the taboo of the leftist groups and the taboo of the Catholic Church, whose head is against abortion under any circumstances. Leftist views insinuate that family planning is the genocidal plan of North American imperialists against the Third World and, in particular, against Latin America. This genocidal plan is supposed to subject poor populations to international schemes. In the press family planning is often treated in a sanctimonious fashion, lumping it together with topics like pornography, sex, and violence. In 1983 the daily newspaper Expreso published a supplement running every week for almost three months about the issue of population, which dealt fairly extensively with such topics as population and housing, education, employment, and urban proliferation, as well as responsible parenthood and child survival. In addition, there was a detailed description of contraceptive methods. In October 1986 another surprising thing happened: the President of Peru talked about the topic of family planning, which at the time was an act of courage. Since then much has changed; the whole world is interested in family planning and certain aspects of population. Since October 1986 more has been published in this domain than during the preceding 20 years. In contrast, the Church reacted differently to this issue: after some initial caution, the conference of Peruvian bishops attacked all methods of modern contraceptives and private institutions of family planning. The information boom in family planning will certainly continue. At the moment this flood of articles and editorials about the issue is an expression of the anxiety of families related to uncontrolled reproduction and the fear of overpopulation in large cities devoid of minimal services. PMID:12281466

  9. Identification of two domains and distal histidine ligands to the four haems in the bacterial c-type cytochrome NapC; the prototype connector between quinol/quinone and periplasmic oxido-reductases.

    PubMed

    Cartron, Michaël L; Roldán, M Dolores; Ferguson, Stuart J; Berks, Ben C; Richardson, David J

    2002-12-01

    NapC is a tetra-haem member of a family of bacterial membrane-anchored multi-haem c -type cytochromes implicated in electron transfer between membrane quinols and periplasmic enzymes. The water-soluble tetra-haem fragment of Paracoccus pantotrophus NapC has been expressed as a periplasmic protein (NapC(sol)) in Paracoccus denitrificans, P. pantotrophus and Escherichia coli. Site-specific mutagenesis of NapC(sol), combined with spectroscopic studies, suggests that each haem iron centre has bis -histidinyl co-ordination. Four proximal ligands arise from each of four Cys-Xaa-Xaa-Cys-His haem-binding motifs; candidates for the four distal ligands are His(81), His(99), His(174) and His(194). NapC(H81A), NapC(H99A), NapC(H174A) and NapC(H194A) mutants (with alanine substituted for each of the four candidate residues) have all been purified from E. coli. In each case, one of the haems has become high-spin, as judged by the presence of a broad absorption band between 620 nm and 650 nm for the oxidized cytochrome; this feature is absent for wild-type protein and presumably arises because of the absence of the distal histidine ligand from one of the haems. NapC(H81A) and NapC(H174A) are less well expressed in E. coli than NapC(H99A) and NapC(H194A) and cannot be detected when expressed in P. denitrificans or P. pantotrophus. In vitro and in vivo complementation studies demonstrate that the soluble periplasmic NapC can mediate electron transfer from quinols to the periplasmic nitrate reductase. This capacity was retained in vitro with the NapC(H99A) and NapC(H194A) mutants but was lost in vivo. A model for the structural organization of NapC(sol) into two domains, each containing a di-haem pair, is proposed. In this model, each haem pair obtains one distal haem ligand from its own domain and a second from the other domain. The suggestion of two domains is supported by observations that the 24 kDa NapC(sol) cleaves to yield a 12 kDa haem-staining band. Determination of the

  10. The Academy of Science of Bologna and the kidney.

    PubMed

    Bonomini, V; Campieri, C; Zuccoli, M

    1999-01-01

    The Academy of Science of Bologna, founded in 1711, played an important role in the development of medicine. Receiving the heritage of Malpighi's and Morgagni's researches, the academy encouraged nephrological studies, which produced articles published in its journal, the Commentarii. Since the Commentarii were widely distributed all over Europe, the nephrological research practiced in Bologna reached all the main academies of science, in a fruitful circulation of knowledge. The paper presents the nephrological contributions to the Commentarii in the 18th century, thus introducing physicians, like Domenico Galeazzi and Luigi Galvani, who were both professors at the University of Bologna and at the Academy of Science. In their work three main topics can be identified: uroscopy, anatomy of the kidney and renal pathologies.

  11. American Academy of Pain Medicine and Integrative Healthcare Symposium.

    PubMed

    Alexander, Walter

    2016-04-01

    Featured topics: benzhydrocodone, hydrocodone, and an opioid taper program at the American Academy of Pain Medicine; and disruption of the gut microbiome by drugs plus new approaches to depression at the Integrative Healthcare Symposium. PMID:27069345

  12. The Academy of Science of Bologna and the kidney.

    PubMed

    Bonomini, V; Campieri, C; Zuccoli, M

    1999-01-01

    The Academy of Science of Bologna, founded in 1711, played an important role in the development of medicine. Receiving the heritage of Malpighi's and Morgagni's researches, the academy encouraged nephrological studies, which produced articles published in its journal, the Commentarii. Since the Commentarii were widely distributed all over Europe, the nephrological research practiced in Bologna reached all the main academies of science, in a fruitful circulation of knowledge. The paper presents the nephrological contributions to the Commentarii in the 18th century, thus introducing physicians, like Domenico Galeazzi and Luigi Galvani, who were both professors at the University of Bologna and at the Academy of Science. In their work three main topics can be identified: uroscopy, anatomy of the kidney and renal pathologies. PMID:10213815

  13. The Press vs. Professional Wrestling: How the Press Covered WrestleMania III.

    ERIC Educational Resources Information Center

    Ortizano, Giacomo L.

    This paper analyzes the relationship between the press and professional wrestling. It examines professional wrestling as a business and the conflicting goals of the promoters and the press. The paper focuses on how the press covered the most widely viewed professional wrestling show of all time, WrestleMania III (looking at newspaper coverage…

  14. Chain Effects: The Impact of Academy Chains on Low Income Students

    ERIC Educational Resources Information Center

    Hutchings, Merryn; Francis, Becky; De Vries, Robert

    2014-01-01

    The authors analysed school performance data to review how well disadvantaged pupils achieve in academy chains. They included chains only if they had at least three academies in 2013, and two sponsored secondary academies for the whole period from September 2010 to July 2013. This means that academies are included in our analysis only when there…

  15. The Impact of Career Academy Programs on Student Achievement in a New Jersey Urban High School

    ERIC Educational Resources Information Center

    Ahmad, Abdul-Azeem

    2009-01-01

    The Talent Development High School (TDHS) reform model, with career academy programs, was introduced at Randolph High School. Three academies were implemented, one called the Arts and Humanities Academy (A&H) focused on careers in creative arts, law, and public service; another titled the Business and Industrial Technology Academy (BAIT) was…

  16. 77 FR 57102 - Board of Visitors for the National Fire Academy

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-17

    ... SECURITY Federal Emergency Management Agency Board of Visitors for the National Fire Academy AGENCY... Committee Meeting. SUMMARY: The Board of Visitors for the National Fire Academy (Board) will meet on October... programs of the National Fire Academy (Academy) and advise the Administrator of the Federal...

  17. 77 FR 41196 - Board of Visitors for the National Fire Academy

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-12

    ... SECURITY Federal Emergency Management Agency Board of Visitors for the National Fire Academy AGENCY... Committee Teleconference Meeting. SUMMARY: The Board of Visitors for the National Fire Academy (Board) will... programs of the National Fire Academy (Academy) and advise the Administrator of the Federal...

  18. 77 FR 21576 - Board of Visitors for the National Fire Academy

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-10

    ... SECURITY Federal Emergency Management Agency Board of Visitors for the National Fire Academy AGENCY... Committee Teleconference Meeting. SUMMARY: The Board of Visitors for the National Fire Academy (Board) will... The purpose of the Board is to review annually the programs of the National Fire Academy (Academy)...

  19. The Prussian Academy of Sciences and Humanities during the Weimar Republic

    ERIC Educational Resources Information Center

    Hardtwig, Wolfgang

    2004-01-01

    The German Revolution of November 1918 dramatically altered the Academy's view of its relationship with government. In particular, the Academy's Prussian tradition had to be rethought. From initial wariness to grudging acceptance, the Academy came to accept the Weimar regime. This paper studies the politics of the Academy, uncovers factions and…

  20. California Partnership Academies: 1987-88 Evaluation Report. Policy Paper No. PP 89-9-1.

    ERIC Educational Resources Information Center

    Dayton, Charles; And Others

    During the 1987-88 school year, 12 academy programs were operating in California under state sponsorship, including the two original Peninsula Academies in operation since 1981, and 10 replications of these, called Partnership Academies. The academies are designed to reduce the number of dropouts among at-risk high school youth. They combine a…

  1. 77 FR 36292 - Proposed Collection, Comments Requested: FBI National Academy Level III Evaluation; FBI National...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-18

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF JUSTICE... Evaluation; FBI National Academy Post-Course Questionnaire for Graduates, FBI National Academy Post-Course... National Academy Post-Course Questionnaire for Graduates. FBI National Academy Post-Course...

  2. A comparison of impulse drying to double felted pressing on pilot- scale shoe presses and roll presses. Progress report, No. 6

    SciTech Connect

    Orloff, D.I.

    1992-08-01

    Pilot-scale shoe press and roll press experiments have been conducted to compare impulse drying and double felted pressing. Both ceramic coated and Beloit Type C press rolls have been evaluated. The experiments show that impulse drying can provide significantly higher outgoing solids than double felled pressing at the same impulse. For example, at an impulse of 0.234 MPa seconds (34 psi seconds), sheets at an ingoing solids of 52% were impulse dried (using the Beloit Type C press roll) to 68% solids while optimized double felled pressing could only yield press dryness of, at most, 60%.

  3. Effects of the transport site conformation on the binding of external NAP-taurine to the human erythrocyte anion exchange system: evidence for intrinsic asymmetry

    SciTech Connect

    Knauf, P.A.; Law, F.Y.; Tarshis, T.; Furuya, W.

    1984-05-01

    External N-(4-azido (NAP-taurine) inhibits human red cell chloride exchange by binding to a site that is distinct from the chloride transport site. Increases in the intracellular chloride concentration (at constant external chloride) cause an increase in the inhibitory potency of external NAP-taurine. This effect is not due to the changes in pH or membrane potential that usually accompany a chloride gradient, since even when these changes are reversed or eliminated the inhibitory potency remains high. According to the ping-pong model for anion exchange, such transmembrane effects of intracellular chloride on external NAP-taurine can be explained if NAP-taurine only binds to its site when the transport site is in the outward-facing (E/sub o/ or ECl/sub o/) form. Since NAP-taurine prevents the conformational change from ECl/sub o/ to ECl/sub i/, it must lock the system in the outward-facing form. NAP-taurine can therefore be used just like the competitive inhibitor H/sub 2/DIDS (4,4'-diisothiocyano-1,2-diphenylethane-2,2'-disulfonic acid) to monitor the fraction of transport sites that face outward. A quantitative analysis of the effects of chloride gradients on the inhibitory potency of NAP-taurine and H/sub 2/DIDS reveals that the transport system is intrinsically asymmetric, such that when Cl/sub i/ = Cl/sub o/, most of the unloaded transport sites face the cytoplasmic side of the membrane. 30 references, 7 figures, 3 tables.

  4. Influence of night-shift and napping at work on urinary melatonin, 17-β-estradiol and clock gene expression in pre-menopausal nurses.

    PubMed

    Bracci, M; Copertaro, A; Manzella, N; Staffolani, S; Strafella, E; Nocchi, L; Barbaresi, M; Copertaro, B; Rapisarda, V; Valentino, M; Santarelli, L

    2013-01-01

    Night-workers experience disruption of the sleep-wake cycle and light at night which may increase breast cancer risk by suppressing the nocturnal melatonin surge, resulting in higher levels of circulating estrogens. Night-work may also deregulate peripheral clock genes which have been found to be altered in breast cancer. This study investigated urinary 6-sulfatoxymelatonin (aMT6s), serum 17-beta-estradiol levels in premenopausal shift nurses at the end of the night-shift compared to a control group of daytime nurses. Peripheral clock gene expression in lymphocytes were also investigated. All participants were sampled in the follicular phase of the menstrual cycle. The effect of nurses’ ability to take a short nap during the night-shift was also explored. The shift-work group had significantly lower aMT6s levels than daytime nurses independently of a nap. Night-shift napping significantly influences 17-beta-estradiol levels resulting in higher outcomes in nurses who do not take a nap compared to napping group and daytime workers. Peripheral clock genes expression investigated was not significantly different among the groups. Our findings suggest that shift nurses experience changes in aMT6s levels after a night-shift. Napping habits influence 17-beta-estradiol levels at the end of a night-shift. These findings might be related to the increased cancer risk reported in night-shift workers and suggest that a short nap during night-shifts may exert a positive effect. PMID:23489707

  5. Influence of night-shift and napping at work on urinary melatonin, 17-β-estradiol and clock gene expression in pre-menopausal nurses.

    PubMed

    Bracci, M; Copertaro, A; Manzella, N; Staffolani, S; Strafella, E; Nocchi, L; Barbaresi, M; Copertaro, B; Rapisarda, V; Valentino, M; Santarelli, L

    2013-01-01

    Night-workers experience disruption of the sleep-wake cycle and light at night which may increase breast cancer risk by suppressing the nocturnal melatonin surge, resulting in higher levels of circulating estrogens. Night-work may also deregulate peripheral clock genes which have been found to be altered in breast cancer. This study investigated urinary 6-sulfatoxymelatonin (aMT6s), serum 17-beta-estradiol levels in premenopausal shift nurses at the end of the night-shift compared to a control group of daytime nurses. Peripheral clock gene expression in lymphocytes were also investigated. All participants were sampled in the follicular phase of the menstrual cycle. The effect of nurses’ ability to take a short nap during the night-shift was also explored. The shift-work group had significantly lower aMT6s levels than daytime nurses independently of a nap. Night-shift napping significantly influences 17-beta-estradiol levels resulting in higher outcomes in nurses who do not take a nap compared to napping group and daytime workers. Peripheral clock genes expression investigated was not significantly different among the groups. Our findings suggest that shift nurses experience changes in aMT6s levels after a night-shift. Napping habits influence 17-beta-estradiol levels at the end of a night-shift. These findings might be related to the increased cancer risk reported in night-shift workers and suggest that a short nap during night-shifts may exert a positive effect.

  6. In the Stocks: Perilous Press Releases.

    ERIC Educational Resources Information Center

    Morton, Linda P.; Loving, Bill

    1994-01-01

    Reviews some of the legal responsibilities of public relations practitioners in the preparation of press releases. Discusses legal criteria for judging the fraudulence of press releases and discusses the timeframe for fraudulent action. Concludes with lessons that practitioners need to understand. (SR)

  7. The Egyptian Press: An Official Fourth Estate.

    ERIC Educational Resources Information Center

    Lawhorne, Clifton O.

    A descriptive study based on Egyptian law, printed sources, and interviews clarifies our picture of the Egyptian Press by examining its status as a constitutionally mandated "Fourth Estate." The constitutional amendment, the resultant Egyptian Press Law, and the "Law Of Shame" (all passed in 1980), are designed to create a heavily controlled press…

  8. Fracture toughness of hot-pressed beryllium

    NASA Technical Reports Server (NTRS)

    Lemon, D. D.; Brown, W. F., Jr.

    1985-01-01

    This paper presents the results of an investigation into the fracture toughness, sustained-load flaw growth, and fatigue-crack propagation resistance of S200E hot-pressed beryllium at room temperature. It also reviews the literature pertaining to the influence of various factors on the fracture toughness of hot-pressed beryllium determined using fatigue-cracked specimens.

  9. Characteristics of nitrogen release from synthetic zeolite Na-P1 occluding NH4NO3.

    PubMed

    Park, Man; Kim, Jong Su; Choi, Choong Lyeal; Kim, Jang-Eok; Heo, Nam Ho; Komarneni, Sridhar; Choi, Jyung

    2005-08-18

    Zeolites can accommodate a considerable amount of occluded salt such as NH4NO3, which can serve as a good source of slow-release plant nutrient. This study evaluates the kinetics of ion release from NH4NO3-occluded Na-P1 (N-NaP) using a simulated soil solution and deionized water as leaching solutions. The patterns of ion releases were examined as a function of leaching time under both static and continuous-flow conditions for more than one month. Releases of both NH4+ and NO3- from N-NaP were found to be slow and steady under both the above conditions. The soil solution affected the release of NH4+ and NO3- differently, while deionized water released nearly the same equivalents of these ions. This clearly indicates that ion release from salt-occluded zeolite involves two different reactions, cation exchange and dissolution. The kinetics of ion release from occluded NH4NO3 under static condition was best described by the standard Elovich model while the power function model best expressed these under continuous-flow condition. The initial ion release patterns under both conditions exhibited considerable deviation from the simulated models, probably as a result of the presence of hydrated occluded NH4NO3. Flow condition and the presence of electrolytes in leaching solution affected the release kinetics significantly. Release of occluded NH4NO3 was delayed by the presence of the NH4NO3 coated on zeolite crystals. These results indicate that the ion release property of occluded salt could be predicted and controlled. This study clearly shows that NH4NO3-occluded zeolites could be developed as slow release fertilizers. PMID:15963593

  10. Characteristics of nitrogen release from synthetic zeolite Na-P1 occluding NH4NO3.

    PubMed

    Park, Man; Kim, Jong Su; Choi, Choong Lyeal; Kim, Jang-Eok; Heo, Nam Ho; Komarneni, Sridhar; Choi, Jyung

    2005-08-18

    Zeolites can accommodate a considerable amount of occluded salt such as NH4NO3, which can serve as a good source of slow-release plant nutrient. This study evaluates the kinetics of ion release from NH4NO3-occluded Na-P1 (N-NaP) using a simulated soil solution and deionized water as leaching solutions. The patterns of ion releases were examined as a function of leaching time under both static and continuous-flow conditions for more than one month. Releases of both NH4+ and NO3- from N-NaP were found to be slow and steady under both the above conditions. The soil solution affected the release of NH4+ and NO3- differently, while deionized water released nearly the same equivalents of these ions. This clearly indicates that ion release from salt-occluded zeolite involves two different reactions, cation exchange and dissolution. The kinetics of ion release from occluded NH4NO3 under static condition was best described by the standard Elovich model while the power function model best expressed these under continuous-flow condition. The initial ion release patterns under both conditions exhibited considerable deviation from the simulated models, probably as a result of the presence of hydrated occluded NH4NO3. Flow condition and the presence of electrolytes in leaching solution affected the release kinetics significantly. Release of occluded NH4NO3 was delayed by the presence of the NH4NO3 coated on zeolite crystals. These results indicate that the ion release property of occluded salt could be predicted and controlled. This study clearly shows that NH4NO3-occluded zeolites could be developed as slow release fertilizers.

  11. New Worlds, New Horizons in Astronomy and Astrophysics, Washington, D.C.: National Academies Press, 2010. Panel Reports New Worlds, New Horizons in Astronomy and Astrophysics, Washington, D.C.: National Academies Press, 2010. Report of the Panel on Implementing Recommendations from the New Worlds, New Horizons Decadal Survey, Washington, D.C.: National Academies Press, 2010. 2020 Vision: An Overview of New Worlds, New Horizons in Astronomy and Astrophysics, Washington, D.C.: National Academies Press, 2011

    SciTech Connect

    Shapero, Donald C.

    2012-04-05

    The NRC's Astronomy and Astrophysics decadal survey Astro2010 was organized under the umbrella of the BPA and its sister board the Space Studies Board (SSB). NASA, NSF, and DOE are the sponsors of this survey that was asked to evaluate the field of space- and ground-based astronomy and astrophysics, recommending priorities for the most important scientific and technical activities of the decade 2010-2020. The principal goals of this study were to carry out an assessment of activities in astronomy and astrophysics, including both new and previously identified concept, and to prepare a concise report that addresses the agencies supporting the field, the Congressional committees with jurisdiction over those agencies, the scientific community, and the public. Over the past 40 years, the Astronomy and Astrophysics decadal reviews have played a vital role in the selection of major astronomical activities and subsequent scientific discoveries. Some decadal survey prioritization highlights include the development of adaptive optics systems, the Very Long Baseline Array, the Hubble Space Telescope, and the Spitzer Space Telescope.

  12. Research at the Intersection of the Physical and Life Sciences, Washington, D.C.: National Academies Press, 2010.

    SciTech Connect

    Committee on Forefronts of Science at the Interface of Physical and Life Sciences

    2009-11-01

    Traditionally, the natural sciences have been divided into two branches: the biological sciences and the physical sciences. Today, an increasing number of scientists are addressing problems lying at the intersection of the two. These problems are most often biological in nature, but examining them through the lens of the physical sciences can yield exciting results and opportunities. For example, one area producing effective cross-discipline research opportunities centers on the dynamics of systems. Equilibrium, multi-stability, and stochastic behavior--concepts familiar to physicists and chemists--are now being used to tackle issues associated with living systems such as adaptation, feedback, and emergent behavior. Research at the Intersection of the Physical and Life Sciences discusses how some of the most important scientific and societal challenges can be addressed, at least in part, by collaborative research that lies at the intersection of traditional disciplines, including biology, chemistry, and physics. This book describes how some of the mysteries of the biological world are being addressed using tools and techniques developed in the physical sciences, and identifies five areas of potentially transformative research. Work in these areas would have significant impact in both research and society at large by expanding our understanding of the physical world and by revealing new opportunities for advancing public health, technology, and stewardship of the environment. This report recommends several ways to accelerate such cross-discipline research. Many of these recommendations are directed toward those administering the faculties and resources of our great research institutions--and the stewards of our research funders, making this book an excellent resource for academic and research institutions, scientists, universities, and federal and private funding agencies.

  13. Systemic Mentoring for Competitiveness: The Model of the Timbuktu Academy

    NASA Astrophysics Data System (ADS)

    Bagayoko, Diola

    2010-02-01

    The Timbuktu Academy is a comprehensive, systemic mentoring program at Southern University and A&M College in Baton Rouge (SUBR), Louisiana. We define systemic mentoring as one that is woven into the core functions of an organization. For most universities, those functions include instruction, research, and service. While the Academy has programs for pre-college and graduate students, its Ten-Strand Systemic Mentoring Model was specifically tailored to undergraduate education. We discuss basic considerations that led to the paradigm, programs, activities, and results of the Timbuktu Academy. The proper implementation of the Ten-Strand Systemic Mentoring Model couples teaching and superior learning, on the one hand, and integrates research and education, on the other hand. For undergraduate education, key strands include support (financially or otherwise), scientific advisement, research participation (academic year or summer), immersion in a professional culture, monitoring, and guidance to graduate school. From the summer of 1994 to 2009, the Academy has engaged 2,093 pre-college scholars in its summer programs. To date, the Academy has assisted in the production of one hundred seventy (170) minority undergraduate scholars who have earned a Bachelor of Science degree. Seventy (70) of 83 physics graduates, twenty (20) of 29 chemistry graduates, and twenty-two (22) of 49 engineering graduates have earned graduate degrees or are successfully enrolled in graduate school, with emphasis on the pursuit of the Ph.D. For the above model and results, the Timbuktu Academy received the 2002 U.S. Presidential Award for Excellence in Science, Mathematics, and Engineering Mentoring. Its director was among the first individual recipients of this award in 1996. The handouts accompanying this presentation are intended to facilitate the adaptive replication of the Timbuktu Academy by individuals, departments, colleges and universities, and other organizations. )

  14. Hierarchy of Carbon Source Selection in Paracoccus pantotrophus: Strict Correlation between Reduction State of the Carbon Substrate and Aerobic Expression of the nap Operon

    PubMed Central

    Ellington, M. J. K.; Bhakoo, K. K.; Sawers, G.; Richardson, D. J.; Ferguson, S. J.

    2002-01-01

    Paracoccus pantotrophus can express a periplasmic nitrate reductase (Nap) during aerobic growth. A proposed role for this enzyme is the dissipation of excess redox energy during oxidative metabolism of reduced carbon substrates. To investigate the regulation of nap expression, a transcriptional fusion between the nap promoter region of P. pantotrophus and the lacZ gene was constructed. When this fusion was used, analyses showed that transcription from the nap promoter increases as the average reduction state of the carbon atoms increases. Thus, β-galactosidase activities increase as the carbon source changes in the order succinate-acetate-butyrate. This result was obtained regardless of which of the three carbon sources was used for culture of the inoculum. If two carbon sources were presented together, the β-galactosidase activity was always the same as it was when the least-reduced carbon source was added alone. This suggests that the regulation is dependent upon metabolism of the more-reduced carbon sources rather than just their presence in the medium. Analysis of culture medium by 1H nuclear magnetic resonance showed that for aerobic growth P. pantotrophus strictly selected its carbon source in the order succinate-acetate-butyrate. This was reflected by diauxic growth kinetics on medium containing mixed carbon substrates. The regulatory mechanism underpinning such a selection is unknown but is likely to be related to the mechanism which controls the transcription of the nap operon. PMID:12169601

  15. An AP-1-like transcription factor, NAP-1, regulates expression of the glutathione S-transferase and NADH:flavin oxidoreductase genes in Neurospora crassa.

    PubMed

    Takahashi, Masakazu; Yamashita, Kazuhiro; Shiozawa, Azusa; Ichiishi, Akihiko; Fukumori, Fumiyasu; Fujimura, Makoto

    2010-01-01

    AP-1-like transcription factors play crucial roles in oxidative stress responses in yeast and filamentous fungi. The deletion of an AP-1-like transcription factor gene, nap-1, in Neurospora crassa slightly increased its sensitivity to oxidative stressors, including menadione. Microarray and quantitative real-time reverse transcriptase-PCR analyses were employed to identify menadione-inducible genes (migs) and the roles of NAP-1 in their regulation. N. crassa migs include three putative glutathione S-transferase genes and two NADH:flavin oxidoreductase genes, orthologs of OYE2 and OYE3, both of which play roles in menadione tolerance in Saccharomyces cerevisiae. Menadione induced nuclear localization of NAP-1, and oxidative upregulation of many of migs were NAP-1 dependent. Genes for a thioredoxin, a glutathione reductase, and a glutathione peroxidase were slightly upregulated by the chemical only in the wild-type strain, suggesting that NAP-1 is involved in their oxidative induction and probably dose not contribute to high-level constitutive expressions of such genes.

  16. An intervention to promote healthy weight: Nutrition and Physical Activity Self-Assessment for Child Care (NAP SACC) theory and design.

    PubMed

    Ammerman, Alice S; Ward, Dianne S; Benjamin, Sara E; Ball, Sarah C; Sommers, Janice K; Molloy, Meg; Dodds, Janice M

    2007-07-01

    Health professionals are faced with the growing challenge of addressing childhood overweight. Few overweight prevention efforts have targeted young children, particularly children in child care settings. We describe the theory and development of a novel nutrition and physical activity environmental intervention. On the basis of findings from interviews and focus groups, a review of national recommendations and standards, and a review of the literature, we developed a nutrition and physical activity environmental self-assessment instrument to assess physical activity and nutrition policies and practices in child care settings. An intervention model was built around existing public health infrastructure to support use of the self-assessment instrument and encourage environmental changes at the child care level, and this intervention model became the Nutrition and Physical Activity Self-Assessment for Child Care (NAP SACC) program. The NAP SACC program was designed for dissemination and has potential for implementation in many settings. Broad interest in NAP SACC has been expressed by a number of states and institutions, and many groups are using NAP SACC intervention and materials. The NAP SACC program shows promise as a useful approach to promoting healthy weight behaviors in child care settings.

  17. A single administration of the peptide NAP induces long-term protective changes against the consequences of head injury: gene Atlas array analysis.

    PubMed

    Romano, Jacob; Beni-Adani, Liana; Nissenbaum, Orlev Levy; Brenneman, Douglas E; Shohami, Esther; Gozes, Illana

    2002-01-01

    The femtomolar-acting eight-amino-acid peptide (NAP), derived from activity-dependent neuroprotective protein (ADNP), provides long-term protection against the deleterious effects of closed head injury (CHI) in mice. Fifteen minutes after injury, mice were divided into two groups, control and NAP-treated and a single subcutaneous injection of NAP or vehicle was administered. A third group served as sham-treated (not subjected to head trauma). Each mouse was assessed for its clinical function, using neurological severity score, at various time intervals following CHI, up to 30-45 d. Total cerebral cortex RNA was prepared from the site of injury of CHI mice, and from parallel regions in peptide-treated and sham brains. RNA was then reversed transcribed to yield radioactive cDNA preparations that were hybridized to Atlas array membranes containing 1200 cDNAs spots. Comparison of sham-treated individual mice showed differential expression levels of at least 15 mRNA species. Furthermore, results indicated that one of the genes that did not change among individuals but specifically increased after CHI and decreased after NAP treatment was the cell surface glycoprotein Mac-1 (CD11B antigen). Thus, Mac-1 is suggested as a marker for the long-term outcome of head injury and as a potential target for NAP protective actions.

  18. Seasonal changes in anthropometric and physical characteristics within English academy rugby league players.

    PubMed

    Till, Kevin; Jones, Ben; Emmonds, Stacey; Tester, Emma; Fahey, Jack; Cooke, Carlton

    2014-09-01

    Professional rugby league clubs implement training programmes for the development of anthropometric and physical characteristics within an academy programme. However, research that examines seasonal changes in these characteristics is limited. The purpose of the study was to evaluate the seasonal changes in anthropometric and physical characteristics of academy rugby league players by age category (i.e., under 14, 16, 18, 20). Data were collected on 75 players pre- and postseason over a 6-year period (resulting in a total of 195 assessments). Anthropometric (body mass, sum of 4 skinfolds) and physical (10- and 20-m sprint, vertical jump, Yo-Yo intermittent recovery test and 1 repetition maximum squat, bench press, and prone row) measures were collected. The under 14s and 16s showed greater seasonal improvements in body mass (e.g., under 14s = 7.4 ± 4.3% vs. under 20s = 1.2 ± 3.3%) and vertical jump performance than under 18s and under 20s. In contrast, under 18s and under 20s players showed greater seasonal improvements in Yo-Yo performance and 10-m sprint (e.g., under 14s = 1.3 ± 3.9% vs. under 20s = -1.9 ± 1.2%) in comparison to under 14s and under 16s. Seasonal strength improvements were greater for the under 18s compared with under 20s. This study provides comparative data for seasonal changes in anthropometric and physical characteristics within rugby league players aged 13-20 years. Coaches should be aware that seasonal improvements in speed may not exist within younger age categories, until changes in body mass stabilize and consider monitoring changes in other characteristics (e.g., momentum). Large interplayer variability suggests that player development should be considered on an individual and longitudinal basis.

  19. 5th National Audit Project (NAP5) on accidental awareness during general anaesthesia: summary of main findings and risk factors.

    PubMed

    Pandit, J J; Andrade, J; Bogod, D G; Hitchman, J M; Jonker, W R; Lucas, N; Mackay, J H; Nimmo, A F; O'Connor, K; O'Sullivan, E P; Paul, R G; Palmer, J H M G; Plaat, F; Radcliffe, J J; Sury, M R J; Torevell, H E; Wang, M; Hainsworth, J; Cook, T M

    2014-10-01

    We present the main findings of the 5th National Audit Project (NAP5) on accidental awareness during general anaesthesia (AAGA). Incidences were estimated using reports of accidental awareness as the numerator, and a parallel national anaesthetic activity survey to provide denominator data. The incidence of certain/probable and possible accidental awareness cases was ~1:19,600 anaesthetics (95% confidence interval 1:16,700-23,450). However, there was considerable variation across subtypes of techniques or subspecialities. The incidence with neuromuscular block (NMB) was ~1:8200 (1:7030-9700), and without, it was ~1:135,900 (1:78,600-299,000). The cases of AAGA reported to NAP5 were overwhelmingly cases of unintended awareness during NMB. The incidence of accidental awareness during Caesarean section was ~1:670 (1:380-1300). Two-thirds (82, 66%) of cases of accidental awareness experiences arose in the dynamic phases of anaesthesia, namely induction of and emergence from anaesthesia. During induction of anaesthesia, contributory factors included: use of thiopental, rapid sequence induction, obesity, difficult airway management, NMB, and interruptions of anaesthetic delivery during movement from anaesthetic room to theatre. During emergence from anaesthesia, residual paralysis was perceived by patients as accidental awareness, and commonly related to a failure to ensure full return of motor capacity. One-third (43, 33%) of accidental awareness events arose during the maintenance phase of anaesthesia, mostly due to problems at induction or towards the end of anaesthesia. Factors increasing the risk of accidental awareness included: female sex, age (younger adults, but not children), obesity, anaesthetist seniority (junior trainees), previous awareness, out-of-hours operating, emergencies, type of surgery (obstetric, cardiac, thoracic), and use of NMB. The following factors were not risk factors for accidental awareness: ASA physical status, race, and use or omission

  20. Powder pressing in a macrosonic field

    NASA Technical Reports Server (NTRS)

    Protipopescu, A.; Dragan, O.; Ciovica, D.

    1974-01-01

    An investigation was conducted to extend the technology of powder product manufacturing to new forms and sizes, to improve their quality as well as pressing efficiency and to reduce waste. In the course of metal and nonmetal powder briquette pressing, macrosounds were associated with the external static pressing force, which led to an increase in the relative height, density and physicomechanical characteristics of the briquettes. This method permits the extension of the range of products that can be manufactured from powders and the improvement of their quality.

  1. STS-8 onboard crew press conference

    NASA Technical Reports Server (NTRS)

    1983-01-01

    Six news reporters listen to a response from Astronaut Guion S. Bluford (note TV monitor) in a rare space-to-Earth press conference involving all the STS-8 crew. The participants are, left to right, Gary Schwitzer, Cable News Network; Morton Dean, CBS; Roy Neal, NBC; Lynn Sherr, ABC; Howard Benedict, Associated Press; Al Rossiter, United Press International. The astronauts on the monitor are Richard H. Truly, cneter left, crew commander; Daniel C. Brandenstein, lower left, pilot; and Dr. William E. Thornton, upper left, Guion S. Bluford, upper right; and Dale E. Gardner, all mission specialists.

  2. An American Academy for Training Safeguards Inspectors - An Idea Revisited

    SciTech Connect

    Philip Casey Durst; Robert Bean

    2010-07-01

    In 2009, we presented the idea of an American academy for training safeguards inspectors for the International Atomic Energy Agency (IAEA), due to the declining percentage of Americans in that international organization. In this paper we assert that there is still a compelling need for this academy. While the American Safeguards Academy would be useful in preparing and pre-training American inspectors for the IAEA, it would also be useful for preparing Americans for domestic safeguards duties in the U.S. Department of Energy (DOE), U.S. DOE National Laboratories, and the U.S. Nuclear Regulatory Commission (NRC). It is envisioned that such an academy would train graduate and post-graduate university students, DOE National Laboratory interns, and nuclear safeguards professionals in the modern equipment, safeguards measures, and approaches currently used by the IAEA. It is also envisioned that the Academy would involve the domestic nuclear industry, which could provide use of commercial nuclear facilities for tours and demonstrations of the safeguards tools and methods in actual nuclear facilities. This would be in support of the U.S. DOE National Nuclear Security Administration’s Next Generation Safeguards Initiative (NGSI). This training would also help American nuclear safeguards and non-proliferation professionals better understand the potential limitations of the current tools used by the IAEA and give them a foundation from which to consider even more effective and efficient safeguards measures and approaches.

  3. CosmoAcademy Training and Certification for Scientists and Engineers

    NASA Astrophysics Data System (ADS)

    Noel-Storr, Jacob; Buxner, Sanlyn; Grier, Jennifer A.; Gay, Pamela L.; CosmoQuest Team

    2016-10-01

    CosmoQuest is a virtual research facility bringing together scientists, citizens, and learners of all ages. CosmoQuest offers classes, training, and learning opportunities online through CosmoAcademy, offering opportunities for all kinds of learners to become more connected to the science of the Universe. In this poster we describe CosmoAcademy opportunities for Subject Matter Experts (SMEs), scientists and engineers who are interested in broadening their impact of their work by providing learning opportunities for those outside of the scientific community. CosmoAcademy offers SME programs at a variety of levels and across a variety of topics in formal and informal education and outreach -- ranging from sharing the results of your work on social media, through delivering an online class series, to partnering with teachers and schools. SMEs may combine sequences of training to earn certification at various levels for their participation in the CosmoAcademy programs. SMEs who have been trained may also apply to teach CosmoAcademy classes for the community on subjects of their expertise to build a rich and engaging learning resource for members of society who wish to understand more about the Universe.

  4. Designing and implementing the Army Nursing Leader Academy.

    PubMed

    Dunemn, Kathleen; Hopkins-Chadwick, Denise L; Connally, Tina; Bramley, Kelly

    2011-01-01

    In 2008, the Chief of the Army Nurse Corps directed a thorough review of existing training programs available to and provided for Army Nursing personnel for the development of full-spectrum leaders for Army Nursing. The review provided the gap analysis necessary to restructure courses provided by the Department of Nursing Science at the Army Medical Department Center and School. This new grouping of courses is referred to as the Army Nursing Leader Academy. The Army Nursing Leader Academy is the first of its kind in that it addresses career-long learning of all Army Nursing by focusing on building skills, knowledge, and behaviors to produce sustainable, full-spectrum leaders. The Nursing Leader Academy consists of a series of sequential nurse leader development courses combined with a web based resource center. Grounded in the Patient CaringTouch System, guided by nurse competencies, and gauged by the Leader Capabilities Map, the Nursing Leader Academy provides learning that is relevant and timely designed to reinforce enterprise values and culture to ensure readiness for successive roles and positions. Full implementation of the Nursing Leader Academy will include the evidence-based elements of formal schooling, coaching, self-development, functional/technical (competency attainment), and professional experiences.

  5. The Management Academy for Public Health: the South Carolina experience.

    PubMed

    Cumbey, Dorothy A; Ellison, Lu Anne

    2006-01-01

    In the late 1990s, the South Carolina Department of Health and Environmental Control (SCDHEC) was faced with the challenges of a workforce that was not prepared in public health; the impending loss of significant agency expertise, leadership, and institutional knowledge through retirement; the lack of available and accessible training; and continuing state budget cuts. Preparedness for bioterrorism and other public health emergencies was also of concern, a need made more urgent after 2001. To respond to current and emerging public health challenges, the SCDHEC had to have a workforce with the knowledge and skills necessary for the delivery of essential public health services. To address these challenges, the department partnered with the University of North Carolina in the pilot of the Management Academy for Public Health. The Management Academy is now integrated into the South Carolina workforce development strategy, and 199 staff members and 22 community partners have graduated from the program. Along with increased knowledge, skills, and abilities of individual staff and increased organizational and community capacity, a significant result of South Carolina's experience with the Management Academy for Public Health is the development of a training program for emergency preparedness modeled on the Management Academy. This highly successful program illustrates the replicability of the Management Academy model. PMID:16912610

  6. Designing and implementing the Army Nursing Leader Academy.

    PubMed

    Dunemn, Kathleen; Hopkins-Chadwick, Denise L; Connally, Tina; Bramley, Kelly

    2011-01-01

    In 2008, the Chief of the Army Nurse Corps directed a thorough review of existing training programs available to and provided for Army Nursing personnel for the development of full-spectrum leaders for Army Nursing. The review provided the gap analysis necessary to restructure courses provided by the Department of Nursing Science at the Army Medical Department Center and School. This new grouping of courses is referred to as the Army Nursing Leader Academy. The Army Nursing Leader Academy is the first of its kind in that it addresses career-long learning of all Army Nursing by focusing on building skills, knowledge, and behaviors to produce sustainable, full-spectrum leaders. The Nursing Leader Academy consists of a series of sequential nurse leader development courses combined with a web based resource center. Grounded in the Patient CaringTouch System, guided by nurse competencies, and gauged by the Leader Capabilities Map, the Nursing Leader Academy provides learning that is relevant and timely designed to reinforce enterprise values and culture to ensure readiness for successive roles and positions. Full implementation of the Nursing Leader Academy will include the evidence-based elements of formal schooling, coaching, self-development, functional/technical (competency attainment), and professional experiences. PMID:22124867

  7. Longitudinal development of anthropometric and physical characteristics within academy rugby league players.

    PubMed

    Till, Kevin; Jones, Ben; Darrall-Jones, Josh; Emmonds, Stacey; Cooke, Carlton

    2015-06-01

    The purpose of this study was to evaluate the annual and long-term (i.e., 4 years) development of anthropometric and physical characteristics in academy (16-20 years) rugby league players. Players were assessed at the start of preseason over a 6-year period and were required to be assessed on consecutive years to be included in the study (Under 16-17, n = 35; Under 17-18, n = 44; Under 18-19, n = 35; Under 19-20, n = 16). A subset of 15 players were assessed for long-term changes over 4 years (Under 16-19). Anthropometric (height, body mass, sum of 4 skinfolds) and physical (10- and 20-m sprint, 10-m momentum, vertical jump, yo-yo intermittent recovery test level 1, 1 repetition maximum [1RM] squat, bench press, and prone row) assessments were collected. Paired t-tests and repeated measures analysis of variance demonstrated significant annual (e.g., body mass, U16 = 76.4 ± 8.4, U17 = 81.3 ± 8.3 kg; p < 0.001, d = 0.59) and long-term (e.g., vertical jump, Under 16 = 44.1 ± 3.8, Under 19 = 52.1 ± 5.3 cm; p < 0.001, d = 1.74) changes in anthropometric and physical characteristics. Greater percentage changes were identified between the Under 16-17 age categories compared with the other ages (e.g., 1RM squat, U16-17 = 22.5 ± 19.5 vs. U18-19 = 4.8 ± 6.4%). Findings demonstrate the annual and long-term development of anthropometric and physical characteristics in academy rugby league players establishing greater changes occur at younger ages upon the commencement of a structured training program within an academy. Coaches should understand the long-term development of physical characteristics and use longitudinal methods for monitoring and evaluating player performance and development.

  8. Gas-driven filter pressing in magmas

    USGS Publications Warehouse

    Sisson, T.W.; Bacon, C.R.

    1999-01-01

    Most silicic and some mafic magmas expand via second boiling if they crystallize at depths of about 10 km or less. The buildup of gas pressure due to second boiling can be relieved by expulsion of melt out of the region of crystallization, and this process of gas-driven filter pressing assists the crystallization differentiation of magmas. For gas-driven filter pressing to be effective, the region of crystallization must inflate slowly relative to buildup of pressure and expulsion of melt These conditions are satisfied in undercooled magmatic inclusions and in thin sheets of primitive magma underplating cooler magma reservoirs. Gas-driven filter pressing thereby adds fractionated melt to magma bodies. Gas-driven filter pressing is probably the dominant process by which highly evolved melts segregate from crystal mush to form aplitic dikes in granitic plutons; this process could also account for the production of voluminous, crystal-poor rhyolites.

  9. Health policy, ethics, and the Kansas Legislative Health Academy.

    PubMed

    Blacksher, Erika; Maree, Gina; Schrandt, Suzanne; Soderquist, Chris; Steffensmeier, Tim; St Peter, Robert

    2015-03-01

    We describe a unique program, the Kansas Legislative Health Academy, that brings together state legislators from across the political spectrum to build their capacity in advancing policies that can improve the health of Kansans. To that end, the academy helps legislators develop new skills to deliberate the ethics of health policy, use systems thinking to understand the long- and short-term effects of policy action and inaction, and engage in acts of civic leadership. The academy also seeks to foster an environment of respectful open dialogue and to build new cross-chamber and cross-party relationships. Among the most important outcomes cited by program participants is the value of sustained, personal interaction and problem solving with individuals holding differing political views.

  10. Health policy, ethics, and the Kansas Legislative Health Academy.

    PubMed

    Blacksher, Erika; Maree, Gina; Schrandt, Suzanne; Soderquist, Chris; Steffensmeier, Tim; St Peter, Robert

    2015-03-01

    We describe a unique program, the Kansas Legislative Health Academy, that brings together state legislators from across the political spectrum to build their capacity in advancing policies that can improve the health of Kansans. To that end, the academy helps legislators develop new skills to deliberate the ethics of health policy, use systems thinking to understand the long- and short-term effects of policy action and inaction, and engage in acts of civic leadership. The academy also seeks to foster an environment of respectful open dialogue and to build new cross-chamber and cross-party relationships. Among the most important outcomes cited by program participants is the value of sustained, personal interaction and problem solving with individuals holding differing political views. PMID:25607945

  11. [Navy medical academy (to the 75th anniversary of establishment)].

    PubMed

    Chernikov, O G; Zaimagov, S V

    2016-02-01

    The article is devoted to the history of the creation in 1940 of the Naval Medical Academy on the basis of the 3rd Leningrad Medical Institute and the Institute for sanitary-chemical protection of the People's Commissariat of the USSR. The structure of this institution included, faculties management staff of the medical service, medical and sanitation, Higher Naval Medical School, the Marine Research Institute Medical, higher courses for officers of the medical service, clinical naval hospital. During the period of its activity (1940-1956), the staff of the Naval Medical Academy made a great contribution to the naval medicine and practical public health. The merit of the Academy is not only a beautifully staged academic, medical, research process, but also in the creation of the spirit of the high sea camaraderie, accomplishment and pride for the work which its graduates have dedicated their lives. PMID:27263215

  12. The Periplasmic Nitrate Reductase Nap Is Required for Anaerobic Growth and Involved in Redox Control of Magnetite Biomineralization in Magnetospirillum gryphiswaldense

    PubMed Central

    Li, Yingjie; Katzmann, Emanuel; Borg, Sarah

    2012-01-01

    The magnetosomes of many magnetotactic bacteria consist of membrane-enveloped magnetite crystals, whose synthesis is favored by a low redox potential. However, the cellular redox processes governing the biomineralization of the mixed-valence iron oxide have remained unknown. Here, we show that in the alphaproteobacterium Magnetospirillum gryphiswaldense, magnetite biomineralization is linked to dissimilatory nitrate reduction. A complete denitrification pathway, including gene functions for nitrate (nap), nitrite (nir), nitric oxide (nor), and nitrous oxide reduction (nos), was identified. Transcriptional gusA fusions as reporters revealed that except for nap, the highest expression of the denitrification genes coincided with conditions permitting maximum magnetite synthesis. Whereas microaerobic denitrification overlapped with oxygen respiration, nitrate was the only electron acceptor supporting growth in the entire absence of oxygen, and only the deletion of nap genes, encoding a periplasmic nitrate reductase, and not deletion of nor or nos genes, abolished anaerobic growth and also delayed aerobic growth in both nitrate and ammonium media. While loss of nosZ or norCB had no or relatively weak effects on magnetosome synthesis, deletion of nap severely impaired magnetite biomineralization and resulted in fewer, smaller, and irregular crystals during denitrification and also microaerobic respiration, probably by disturbing the proper redox balance required for magnetite synthesis. In contrast to the case for the wild type, biomineralization in Δnap cells was independent of the oxidation state of carbon substrates. Altogether, our data demonstrate that in addition to its essential role in anaerobic respiration, the periplasmic nitrate reductase Nap has a further key function by participating in redox reactions required for magnetite biomineralization. PMID:22730130

  13. The napF and narG Nitrate Reductase Operons in Escherichia coli Are Differentially Expressed in Response to Submicromolar Concentrations of Nitrate but Not Nitrite

    PubMed Central

    Wang, Henian; Tseng, Ching-Ping; Gunsalus, Robert P.

    1999-01-01

    Escherichia coli synthesizes two biochemically distinct nitrate reductase enzymes, a membrane-bound enzyme encoded by the narGHJI operon and a periplasmic cytochrome c-linked nitrate reductase encoded by the napFDAGHBC operon. To address why the cell makes these two enzymes, continuous cell culture techniques were used to examine napF and narG gene expression in response to different concentrations of nitrate and/or nitrite. Expression of the napF-lacZ and narG-lacZ reporter fusions in strains grown at different steady-state levels of nitrate revealed that the two nitrate reductase operons are differentially expressed in a complementary pattern. The napF operon apparently encodes a “low-substrate-induced” reductase that is maximally expressed only at low levels of nitrate. Expression is suppressed under high-nitrate conditions. In contrast, the narGHJI operon is only weakly expressed at low nitrate levels but is maximally expressed when nitrate is elevated. The narGHJI operon is therefore a “high-substrate-induced” operon that somehow provides a second and distinct role in nitrate metabolism by the cell. Interestingly, nitrite, the end product of each enzyme, had only a minor effect on the expression of either operon. Finally, nitrate, but not nitrite, was essential for repression of napF gene expression. These studies reveal that nitrate rather than nitrite is the primary signal that controls the expression of these two nitrate reductase operons in a differential and complementary fashion. In light of these findings, prior models for the roles of nitrate and nitrite in control of narG and napF expression must be reconsidered. PMID:10464201

  14. The periplasmic nitrate reductase nap is required for anaerobic growth and involved in redox control of magnetite biomineralization in Magnetospirillum gryphiswaldense.

    PubMed

    Li, Yingjie; Katzmann, Emanuel; Borg, Sarah; Schüler, Dirk

    2012-09-01

    The magnetosomes of many magnetotactic bacteria consist of membrane-enveloped magnetite crystals, whose synthesis is favored by a low redox potential. However, the cellular redox processes governing the biomineralization of the mixed-valence iron oxide have remained unknown. Here, we show that in the alphaproteobacterium Magnetospirillum gryphiswaldense, magnetite biomineralization is linked to dissimilatory nitrate reduction. A complete denitrification pathway, including gene functions for nitrate (nap), nitrite (nir), nitric oxide (nor), and nitrous oxide reduction (nos), was identified. Transcriptional gusA fusions as reporters revealed that except for nap, the highest expression of the denitrification genes coincided with conditions permitting maximum magnetite synthesis. Whereas microaerobic denitrification overlapped with oxygen respiration, nitrate was the only electron acceptor supporting growth in the entire absence of oxygen, and only the deletion of nap genes, encoding a periplasmic nitrate reductase, and not deletion of nor or nos genes, abolished anaerobic growth and also delayed aerobic growth in both nitrate and ammonium media. While loss of nosZ or norCB had no or relatively weak effects on magnetosome synthesis, deletion of nap severely impaired magnetite biomineralization and resulted in fewer, smaller, and irregular crystals during denitrification and also microaerobic respiration, probably by disturbing the proper redox balance required for magnetite synthesis. In contrast to the case for the wild type, biomineralization in Δnap cells was independent of the oxidation state of carbon substrates. Altogether, our data demonstrate that in addition to its essential role in anaerobic respiration, the periplasmic nitrate reductase Nap has a further key function by participating in redox reactions required for magnetite biomineralization.

  15. Rein and Zheng Elected to American Academy of Microbiology | Poster

    Cancer.gov

    By Nancy Parrish, Staff Writer Earlier this year, Alan Rein, Ph.D., and Zhi-Ming (Thomas) Zheng, M.D., Ph.D., were elected to fellowship in the American Academy of Microbiology, the honorific leadership group within the American Society for Microbiology (ASM). They were among 88 microbiologists who were elected to the academy “through a highly selective, peer-review process, based on their records of scientific achievement and original contributions that have advanced microbiology,” according to the society’s website.

  16. Rethinking Leadership in the Academy: An Australian Case

    ERIC Educational Resources Information Center

    Bianchini, Stefano; Maxwell, Tudor; Dovey, Ken

    2014-01-01

    As with higher education institutions in other Organisation for Economic Cooperation and Development countries, Australian universities are facing significant challenges. One particular challenge is that of the declining quality of the teaching and learning experience within the academy. This paper describes an attempt to sustain the quality of a…

  17. Second Chances Academy: Alternative School or Pathway to Prison?

    ERIC Educational Resources Information Center

    Horsford, Sonya Douglass; Powell, Keyona L.

    2016-01-01

    This case considers the leadership challenge facing district officials in a mid-sized urban-suburban school district receiving negative media coverage for the overrepresentation of poor, Black, and Latino males in its alternative high school, Second Chances Academy. Many of its students also qualify for special education and English learner…

  18. [Lancisi, Baglivi and the medical academies in Rome].

    PubMed

    Angeletti, L R

    2000-01-01

    Many medical academies were active in Rome during the 17th century; they were promoted by noble patrons, ecclesiastics or eminent physicians, and equipped with libraries. Their role was important in the spreading of the new biomedical thought, founded on the comparison between ideas and experimental data. As an epistemological heritage of Marcello Malpighi and as a connection to the new scientific European ideas, Baglivi directed his efforts towards a leading role of the experimental observations, whereas his predecessor Lancisi was bound to the theorical "ipse dixit" role of the masters of medicine. The analysis of the statutes of the Roman Academies bring to light the new experimentalism, due to the "virtuosi" (vituous men) and "curiosoni" (inquisitive/odd persons) of the Academies: Baglivi, in his De praxi medica, invites the princes to establish in every Metropolitan Hospital an Academy - Medicorum Collegium, in which discussion on clinical aspects should be performed: extraordinary importance is devoted to the epistemological difference between "experientia" (guided in the profession by a membrum - litteratum, thought the direct comparison on the texts) and "experimentum" (following the clinical observation, guided by a membrum historicum-practicum).

  19. The Prussian Academy of Sciences during the Third Reich

    ERIC Educational Resources Information Center

    Notzoldt, Peter; Walther, Peter Th.

    2004-01-01

    In 1933, the Prussian Academy of Sciences and Humanities was an exclusive learned society, out of touch with modern methods and funding, which had also failed to re-establish itself as a "centre of research". During the Nazi regime, it was at best peripherally involved in the restructuring of German academia. While some of its members played a…

  20. The Agony or the Ecstasy? The Academy at the Crossroads.

    ERIC Educational Resources Information Center

    Wheal, James R.

    2000-01-01

    Contemporary schooling, particularly high schools, could benefit from a return to the model of Plato's Academy in which ecstatic experience provided a central and informative role in addressing the higher stages of human development. Supplementing traditional curricula with integral practices that address body, mind, and spirit, and reviving the…

  1. 75 FR 21223 - National Academy of Sciences Study

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-23

    ... INVESTIGATION BOARD National Academy of Sciences Study AGENCY: Chemical Safety and Hazard Investigation Board... of Sciences (NAS) to examine the use and storage of methyl isocyanate, including the feasibility of... CropScience facility in Institute, West Virginia. With this notice, the CSB is outlining the scope...

  2. Personality Traits of Police Cadets: Relationship to Academy Performance.

    ERIC Educational Resources Information Center

    Topp, Bruce W.; Kardash, Carol Anne

    A study examined the relationship of the personality traits of 94 police cadets to their performance at a southwestern state law enforcement academy. The overall training success (percentage of total points earned) of recruits enrolled in 11 weeks of on-site training classes was the primary criterion of the study, and raw personality factor scores…

  3. Performatively Queer: Sole Parent Postgraduates in the Australian Academy

    ERIC Educational Resources Information Center

    Hook, Genine A.

    2015-01-01

    This paper draws on research that considers how gender and agency influence the engagement of sole parent postgraduates within the Australian academy. I argue that parental care responsibilities critically influence participation in higher education for sole parents. I suggest that the gendered construct of caring for children is a feminine…

  4. The Air Force Academy Instructor Workstation (IWS): II. Effectiveness.

    ERIC Educational Resources Information Center

    Gist, Thomas E.; And Others

    1989-01-01

    Discusses the results of measuring the in-class effectiveness of a computer-controlled instructor workstation (IWS) that was developed at the Air Force Academy. Treatments for the experimental and control groups in an introductory physics course are described, and effects on student performance, student attitudes, and instructor attitudes are…

  5. The Role of the Humanities in Decolonising the Academy

    ERIC Educational Resources Information Center

    Prinsloo, Estelle H.

    2016-01-01

    This short paper argues that the #RhodesMustFall movement, which originated at the University of Cape Town, has brought renewed attention to the need to decolonise the academy in South Africa. It further argues that the Humanities are ideally placed to engage with the intellectual problems and questions presented by the decolonisation debate. Deep…

  6. KIPP DIAMOND Academy Year Three (2004-2005) Evaluation Report

    ERIC Educational Resources Information Center

    Thompson, Susan; McDonald, Aaron; Sterbinsky, Allan

    2005-01-01

    The purpose of the present evaluation study was to examine the progress made in program implementation, school climate, and student achievement by the KIPP (Knowledge Is Power Program) DIAMOND (Daring Individual Achievers Making Outstanding New Dreams) Academy (KIPP:DA) housed in Cypress Junior High School in Memphis, Tennessee. The school began…

  7. KIPP DIAMOND Academy: Year Three (2004-2005) Evaluation Report

    ERIC Educational Resources Information Center

    Thompson, Susan, McDonald, Aaron; Sterbinsky, Allan

    2005-01-01

    The KIPP (Knowledge Is Power Program) Diamond (Daring Individual Achievers Making Outstanding New Dreams) Academy, housed in Cypress Junior High School in Memphis, Tennessee, opened in the summer of 2002. KIPP goals include enhancement of academic achievement and promotion of positive student leadership through an innovative redesign of…

  8. Personal Problems of Seventh-Day Adventist Academy Students

    ERIC Educational Resources Information Center

    Crosby, Ellen; Freed, Shirley; Gabriel, Elvin

    2006-01-01

    The Personal Problems Checklist for Adolescents (PPC-A) was administered to students in 14 Adventist academies for the purpose of determining the extent of their personal problems. Descriptive and inferential statistics were used to analyze the data. The results showed that the top 10 problems were: (1) poor study habits; (2) worrying about future…

  9. Internationalizing the Academy: Lessons of Leadership in Higher Education

    ERIC Educational Resources Information Center

    Merkx, Gilbert W., Ed.; Nolan, Riall W., Ed.

    2015-01-01

    "Internationalizing the Academy" is the first book to offer a detailed look at efforts to bring ambitious and expanding portfolios of international programs to US campuses. Gilbert W. Merkx and Riall W. Nolan, leading figures in the burgeoning international higher education sector, provide a thorough examination of how numerous…

  10. Implementing Ninth Grade Academies in Broward County, Florida

    ERIC Educational Resources Information Center

    Legters, Nettie; Parise, Leigh; Rappaport, Shelley

    2013-01-01

    Researchers from MDRC and Johns Hopkins University partnered with Florida's Broward County Public Schools (BCPS) in 2009 to launch an independent evaluation of the district's initiative to implement Ninth Grade Academies (NGAs) in every district high school. An NGA is a self-contained learning community for ninth-graders that operates as…

  11. Engaged Scholarship in the Academy: Reflections from the Margins

    ERIC Educational Resources Information Center

    Drame, Elizabeth R.; Martell, Sandra Toro; Mueller, Jennifer; Oxford, Raquel; Wisneski, Debora B.; Xu, Yaoying

    2011-01-01

    This paper represents a series of reflections on collective and individual efforts of diverse women scholars to reconcile alternative views of scholarship within the academy. We document our collective experience with embedding the concept of the "scholarship of engagement" in our practice of research, teaching, and service through a process of…

  12. A Day in the Life at DaVita Academy

    ERIC Educational Resources Information Center

    Weinstein, Margery

    2010-01-01

    When a company name means "giving life," the bar for learning and development programs is held high. In this article, the author describes what it takes to graduate from DaVita Academy, the soft skills training program dialysis services company DaVita offers all its employees. DaVita's chief executive officer, Kent Thiry, states that the Academy…

  13. Victims Deserve More: The Building of a Forensics Academy

    ERIC Educational Resources Information Center

    Johnson, Lili K.

    2007-01-01

    Because victims deserve more, The American Academy of Applied Forensics at Central Piedmont Community College was created to link cutting-edge forensics research to its field applications. It does this by enhancing the knowledge, skill, and ability levels of crime scene investigators, thereby increasing the likelihood that truth will be revealed…

  14. The Case: Bunche-Da Vinci Learning Partnership Academy

    ERIC Educational Resources Information Center

    Eisenberg, Nicole; Winters, Lynn; Alkin, Marvin C.

    2005-01-01

    The Bunche-Da Vinci case described in this article presents a situation at Bunche Elementary School that four theorists were asked to address in their evaluation designs (see EJ791771, EJ719772, EJ791773, and EJ792694). The Bunche-Da Vinci Learning Partnership Academy, an elementary school located between an urban port city and a historically…

  15. Empowerment Zone: Coaching Academy Primes Teachers to Become Instructional Leaders

    ERIC Educational Resources Information Center

    Mayer, Linda

    2013-01-01

    This article describes a program instituted by the Northern Valley Schools (New Jersey, USA) Curriculum Consortium's Coaching Academy. This program was born in mid-2012 with the goal of building a cadre of instructional coaches who could provide increased classroom support for teachers to navigate 21st-century educational demands. Planning…

  16. The Academy of Cognitive Therapy: Purpose, History, and Future Prospects

    ERIC Educational Resources Information Center

    Dobson, Keith S.; Beck, Judith S.; Beck, Aaron T.

    2005-01-01

    The Academy of Cognitive Therapy (ACT) was developed as a means to identify and credential mental health professionals who demonstrate competence in cognitive therapy. Its missions include certifying clinicians from all disciplines as competent cognitive therapists and educating the public about this empirically supported treatment. This article…

  17. The Leadership Practices of the Dean of Combined Arms Academy

    ERIC Educational Resources Information Center

    Tafere, Matebe

    2014-01-01

    This study is on the leadership practices of the dean of Combined Army Academy. The research is a qualitative design. The academic staff members were the participants of the study. Formal and informal conversational interview approaches, personal observation and document analysis were the instruments of the study. Thematic analysis was used for…

  18. The Place of the Humanities at a Military Academy

    ERIC Educational Resources Information Center

    Flammang, Lucretia A.

    2007-01-01

    The author, a captain in the U.S. Coast Guard and professor of English at the Coast Guard Academy in New London, Connecticut, argues in this article that, contrary to images perpetuated in popular culture, military officers do not eschew the arts as exemplified in such films as "Platoon" and "Full Metal Jacket" where the audience is expected to…

  19. The National Insurance Academy: Serving India's Insurance Professionals and Researchers

    ERIC Educational Resources Information Center

    Sane, Bhagyashree

    2011-01-01

    This article discusses how a special library can meet the needs of a specific industry. The author focuses on India's National Insurance Academy (NIA) Library, which serves the insurance industry of India and some neighboring countries. It is where the author serves as the chief librarian.

  20. Career Academies: Impacts on Labor Market Outcomes and Educational Attainment

    ERIC Educational Resources Information Center

    Kemple, James J.

    2004-01-01

    Career Academies offer high schools--particularly those in urban communities that struggle to keep students in school and to prepare them for post-secondary education and employment opportunities--a systematic approach to addressing a range of challenges. Typically serving between 150 and 200 students from grades 9 or 10 through grade 12, Career…

  1. Leading the Academy or Being Led? Hong Kong Women Academics

    ERIC Educational Resources Information Center

    Aiston, Sarah Jane

    2014-01-01

    This paper provides a new gender-based analysis of survey data collected on Hong Kong academics in 2008. First, it illustrates the gender differences that exist in the Hong Kong academy. Second, it discusses possible explanations for these differences as informed by the data. And third, it offers a novel argument, again informed by the data, for…

  2. Pinunuuchi Po'og'ani: Southern Ute Indian Academy.

    ERIC Educational Resources Information Center

    Oberly, Stacey Inez (Wachimamachi [Antelope Woman])

    2002-01-01

    Describes the Pinunuuchi Po'og'ani, the Southern Ute Indian Academy, providing Montessori education for Southern Ute tribal members ages 6 weeks through 10 years and reviving the use of the Southern Ute language and culture among young students and their families. Describes how the program supports families, students, and staff, and incorporates…

  3. L'Academie Francaise and Anglophone Language Ideologies

    ERIC Educational Resources Information Center

    Estival, Dominique; Pennycook, Alastair

    2011-01-01

    The notion in popular linguistic discourse that French suffers from a narrow and prescriptive tradition of language policing, with the "Academie Francaise" (AF) as the central player, is frequently contrasted with an image of English as a democratic, borrowing language, better suited to its global role. This misrepresents the role of the AF in the…

  4. Faculty Unions, Business Models, and the Academy's Future

    ERIC Educational Resources Information Center

    Rhoades, Gary

    2011-01-01

    In this article, the author addresses questions about the future of faculty unions, business models, and the academy by providing some current and historical context regarding the causes of and conflicts about faculty unions. He also reviews trends in college and university management over the past three decades, using California, Ohio, and…

  5. Scheduling Guide for Small Learning Communities/Career Academies

    ERIC Educational Resources Information Center

    Clark, Patricia; Dayton, Charles; Tidyman, Susan; Hanna, Tracy

    2006-01-01

    Small Learning Communities (SLCs) and Career Academies, one variety of SLC, have grown rapidly in recent years. They are among the few high school reform approaches that seem promising and popular, bringing students together into cohorts where they support each other, teachers into teams where they do the same, and students and teachers into…

  6. West Virginia University's Health Sciences and Technology Academy

    ERIC Educational Resources Information Center

    Chester, Ann; Dooley, Elizabeth

    2011-01-01

    This article describes the Health Sciences and Technology Academy, an outreach and engagement program by West Virginia University to encourage higher education faculty members and administrators, public school teachers, and community leaders to assume the responsibility of mentoring high school students. The primary goal is to increase the college…

  7. Undergraduate Design Learning in Multiple Partnerships: For Academies

    ERIC Educational Resources Information Center

    Butcher, John; Schaber, Friedemann

    2013-01-01

    This article reports research into undergraduate design learning through an off-campus partnership. The Sorrell Foundation's Joinedupdesign for Academies programme involved partnerships between university design departments, "failing" 11-18 schools and professional designers, in the context of a funding commitment to rebuild/renew…

  8. When the Corporate Storm Strikes the Academy: Faculty Response Required

    ERIC Educational Resources Information Center

    DeBoy, James L.

    2015-01-01

    When the corporate storm strikes the academy, faculty must be willing and able to repel administrative assaults upon academic freedom, shared governance, and tenure. This paper will describe the on-going clash between administrators who embrace the corporate mindset and faculty who cherish traditions of shared governance and collegial…

  9. The CUNY Fatherhood Academy: A Qualitative Evaluation. Research Report

    ERIC Educational Resources Information Center

    McDaniel, Marla; Simms, Margaret C.; Monson, William; de Leon, Erwin

    2015-01-01

    Knowing the economic challenges young fathers without postsecondary education face in providing for their families, New York City's Young Men's Initiative launched a fatherhood program housed in LaGuardia Community College in spring 2012. The CUNY Fatherhood Academy (CFA) aims to connect young fathers to academic and employment opportunities while…

  10. The Status Gap: Female Faculty in the Legal Academy

    ERIC Educational Resources Information Center

    Monopoli, Paula A.

    2014-01-01

    Status in the legal academy can mean two things. The first is one's rank, with the highest status being a tenured, full professor. The second is the prestige of one's home institution in the law school rankings. Women have been graduating from law schools in significant numbers for more than thirty years. However, they continue to be…

  11. Academy Conversion: A View from the Governing Body

    ERIC Educational Resources Information Center

    Gann, Nigel

    2011-01-01

    The case for conversion to academy status is being made in a number of arenas, not least on the Department for Education website. As a matter of balance, school governors considering conversion need to take into account a range of factors. How does this fundamental shift in the ownership of schools fit into a discernible historical pattern?…

  12. The Ohio Principals' Leadership Academy: Entry Year Program.

    ERIC Educational Resources Information Center

    Beebe, Robert J.; Hoffman, Daniel; Lindley, Fred; Prestley, Carole

    The paper is intended to disseminate information and to seek participant suggestions concerning the most recent phase of an ongoing program of state policy research focused on the professional development and state licensure of early career principals. The program, known as the Ohio Principals' Leadership Academy: Entry Year Program (OPLA:EYP), is…

  13. Schools "Flip" for Lesson Model Promoted by Khan Academy

    ERIC Educational Resources Information Center

    Sparks, Sarah D.

    2011-01-01

    The author reports on a "flip model" of instruction that has gotten national media attention lately, thanks to its promotion by Khan Academy, the high-profile nonprofit online-tutoring library created by Salman A. Khan, a Massachusetts Institute of Technology graduate who was looking for a way to help his young relatives with their homework. The…

  14. Hand's Academy Challenge: Some Starter Questions

    ERIC Educational Resources Information Center

    Gardner, Peter

    2014-01-01

    Michael Hand has recently challenged certain religious organisations that run Academies in the United Kingdom to devise and pursue their own faith-based curricula in their schools. In this short article I examine some of the problems Hand's challenge might encounter, including whether religious conceptions of worthwhile activities and of…

  15. Computer Academy. Western Michigan University: Summer 1985-Present.

    ERIC Educational Resources Information Center

    Kramer, Jane E.

    The Computer Academy at Western Michigan University (Kalamazoo) is a series of intensive, one-credit-hour workshops to assist professionals in increasing their level of computer competence. At the time they were initiated, in 1985, the workshops targeted elementary and secondary school teachers and administrators, were offered on Apple IIe…

  16. The French Academy: Arbitrator of Taste, Order, Genius--Immortality.

    ERIC Educational Resources Information Center

    Buzash, Michael D.

    The French Academy is the oldest of the scholarly societies of France. Its ideals and preferences of order, genius, and immortality have influenced the schools, conservatories, universities, and archives and the intellectual and artistic tastes of the time. Its foundation was laid by nine lettered, well-educated laymen and ecclesiastics around…

  17. The School Academies Programme: A New Direction or Total Abandonment?

    ERIC Educational Resources Information Center

    Chitty, Clyde

    2008-01-01

    The concept of City Academies owes much to the plan for a network of City Technology Colleges announced by Conservative Education Secretary Kenneth Baker in 1986. This article argues that all this can be viewed as part of the inroad of business into state education, with private sponsorship seen by government as the magical solution to the…

  18. The CUNY Fatherhood Academy: A Qualitative Evaluation. Executive Summary

    ERIC Educational Resources Information Center

    McDaniel, Marla; Simms, Margaret C.; Monson, William; de Leon, Erwin

    2015-01-01

    Knowing the economic challenges young fathers without postsecondary education face in providing for their families, New York City's Young Men's Initiative launched a fatherhood program housed in LaGuardia Community College in spring 2012. The CUNY Fatherhood Academy (CFA) aims to connect young fathers to academic and employment opportunities while…

  19. Improving the Status of Women in the Academy

    ERIC Educational Resources Information Center

    Gee, Michele V.; Norton, Sue Margaret

    2009-01-01

    While women have always faced gender inequities in the general workplace, the academic world has traditionally prided itself on equality and transparency. Sadly, despite substantial gains in the number of doctorates awarded to women and in their employment in academic institutions, there is still much room for improvement in the academy. The…

  20. Remember 9-11! White Belligerency in the Academy

    ERIC Educational Resources Information Center

    Valandra, Edward C.

    2003-01-01

    This author states that, although white belligerency is not new, it exists in a ubiquitous low to midlevel state. As nonwhite experiences reveal and the white historical record distinctly shows, there has been an ongoing controversy over a whole host of issues within the academy that involve the Color Line, like a racially separate but unequal…

  1. A Proposed E-Learning Policy Field for the Academy

    ERIC Educational Resources Information Center

    Parchoma, Gale

    2006-01-01

    In this article, Lewin's (1951) social field theory is used as a framework for analyzing the potential for implementing scalable and sustainable e-learning initiatives in the academy. Powerful external economic and social forces coming to bear on academic leadership decisions are considered. The impacts of the emergence of the global learning…

  2. Enhancing Literacy for Jobs and Productivity. Academy Final Report.

    ERIC Educational Resources Information Center

    Chynoweth, Judith K.

    This document reports how the Council of State Policy and Planning Agencies (CSPA) Academy process helped nine states develop workplace literacy initiatives involving their governors' offices, the Job Training Partnership Act system, and the educational system. The states were Florida, Idaho, Massachusetts, Michigan, North Carolina, Tennessee,…

  3. Lessons Learned: The Teacher Academy for Mathematics and Science.

    ERIC Educational Resources Information Center

    Allen, Ethan E.; Lederman, Leon

    1998-01-01

    Chartered in 1990 by a consortium of 14 universities an colleges in the Chicago area, the Teachers Academy for Mathematics and Science aimed to improve the inservice training and professional development of K-8 math and science teachers. The accompanying Comprehensive School Development Process has four phases: readiness, instruction,…

  4. Further Reflections on the Great City Academy Fraud

    ERIC Educational Resources Information Center

    Beckett, Francis

    2008-01-01

    Academy sponsors have generally behaved with great arrogance, knowing that they enjoyed the enthusiastic support of Tony Blair's Government. And this has been particularly true of Catholic and evangelical sponsors, who believed that Blair's premiership was the best chance they would ever have of bringing about a seismic shift of power in schools…

  5. Career Academies as Instruments of School Reform and Change

    ERIC Educational Resources Information Center

    Blomenkamp, Joel

    2009-01-01

    For many, today's classroom is a relic of an industrial-age school system that, perhaps, has outlived its usefulness. Educator Joel Blomenkamp suggests that the career academy model is one way to enter a new age of education and learning--one in which students are excited about the acquisition of knowledge because they are learning in a dynamic…

  6. A Contentious Triangle: Grading and Academic Freedom in the Academy

    ERIC Educational Resources Information Center

    Hill, Duncan

    2011-01-01

    This article examines the tensions created by academic freedom and grading in universities between academic staff and academic administration. Additionally, the impact of grading and academic standards on students' academic freedom is addressed, as well as the impact of corporatisation in the academy. By reviewing the existing literature and case…

  7. Graphic Arts: Book Three. The Press and Related Processes.

    ERIC Educational Resources Information Center

    Farajollahi, Karim; And Others

    The third of a three-volume set of instructional materials for a graphic arts course, this manual consists of nine instructional units dealing with presses and related processes. Covered in the units are basic press fundamentals, offset press systems, offset press operating procedures, offset inks and dampening chemistry, preventive maintenance…

  8. Textbook Sales Drop, and University Presses Search for Reasons

    ERIC Educational Resources Information Center

    Howard, Jennifer

    2008-01-01

    This article reports that textbook sales are falling at many university presses, a trend that has accelerated in the past couple of months. That's the word from press directors anxious about the decline but unsure what's causing it or how to stop it. Not every press has been affected. Two of the biggest players, Oxford University Press and…

  9. Along Freedom's Double Edge: The Arab Press Under Israeli Occupation.

    ERIC Educational Resources Information Center

    Nasser, Munir K.

    This paper examines the Arab press under Israeli occupation and presents two hypotheses: freedom of the press under occupation serves both Israeli interests and the Arab population, and freedom of the Arab press under occupation is "relative" and "controlled." By allowing freedom of expression, the Israelis achieve several aims: a free press will…

  10. 75 FR 37780 - Proposed Waivers and Extensions of Project Periods: Presidential Academies and Congressional...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-30

    ... for Students of American History and Civics Education. These regulations, respectively, generally... five-year grants funded under the Presidential Academies for American History and Civics Education... under the Congressional Academies for Students of American History and Civics Education would...

  11. Particle Characterization of Pressed Granular HMX

    NASA Astrophysics Data System (ADS)

    Burnside, N. J.; Son, S. F.; Skidmore, C. B.; Asay, B. W.

    1997-07-01

    Often, little material characterization is reported in studies that use granular explosives, such as deflagration-to-detonation transition (DDT) experiments. This lack of characterization makes modeling and interpretation of the experiments difficult. Further, very little is known about how particle size changes with compaction processes, even for quasi-static pressing. Changes in available surface area could significantly affect the initiation of such materials. In this work we report measurements of the particle size distribution of original granular HMX, as well as the size distribution of pressed (higher density) samples. Scanning electron microscope (SEM) pictures are presented and are found to be useful in interpreting the size distribution measurements of the granular HMX, as well as helping to more fully characterizing the state of the particles. We find that the particle size distribution changes significantly with pressing. That is, particles are observed to be highly fractured and damaged at higher pressed densities. Also, we have found that sample preparation can significantly affect size distribution measurements. In particular, even short duration sonication can have a significant effect on the measured size distributions of pressed HMX samples.

  12. Lever-press conditioning in the crab.

    PubMed

    Abramson, C I; Feinman, R D

    1990-08-01

    An operant chamber has been developed for studying lever-press conditioning in the green crab Carcinus maenas. In one series of experiments, animals were presented with a single bar and were reinforced with food for every bar press. Performance increased over time and high rates of responding were observed after 2 days of training. The response rate was always higher than that for a yoked (noncontingent) control group. When the contingencies were switched, the animals adjusted to the new conditions. Discrimination in the lever-press apparatus was demonstrated in a second experiment in which crabs had to choose between two bars, one (S+) caused food to be dispensed while the other (S-) was inactive. Experimental animals pressed the S+ bar at a significantly higher rate than the S- bar. When the contingencies associated with the lever were reversed, animals learned to switch to the correct bar by the second day. It was not necessary to reinforce every response: animals maintained high rates of responding on a schedule where every other response was reinforced. Animals used different methods of pressing the bar; the most common was extension of the claw, predominantly at the meropodite-carpopodite joint. PMID:2255730

  13. AUPress: A Comparison of an Open Access University Press with Traditional Presses

    ERIC Educational Resources Information Center

    McGreal, Rory; Chen, Nian-Shing

    2011-01-01

    This study is a comparison of AUPress with three other traditional (non-open access) Canadian university presses. The analysis is based on the rankings that are correlated with book sales on Amazon.com and Amazon.ca. Statistical methods include the sampling of the sales ranking of randomly selected books from each press. The results of one-way…

  14. Speaking of a Free Press: 200 Years of Notable Quotations about Press Freedoms.

    ERIC Educational Resources Information Center

    American Newspaper Publishers Association Foundation, Washington, DC.

    Intended to summarize the ideals underlying the struggle for freedom of the press and to reinforce the basic Constitutional principles upon which the United States functions, this collection of quotations reflects the beliefs of prominent people throughout history who have championed press freedom, as well as the ideas of some who have opposed it.…

  15. Rigor and academic achievement: Career academies versus traditional class structure

    NASA Astrophysics Data System (ADS)

    Kyees, Linda L.

    The purpose of this study was to determine if students who attended high school Career Academy classes, as part of Career and Technical Education, showed greater academic achievement than students who attended traditional high school classes. While all participants attended schools in the same school district, and were seeking the same goal of graduation with a standard diploma, the Career Academy students had the benefit of all classes being directed by a team of teachers who helped them connect their learning to their desired career through collaborative learning projects and assignments. The traditional high school classes taught each subject independent of other subjects and did not have specific connections to desired career goals of the students. The study used a causal-comparative research design and the participants included 1,142 students from 11th and 12th grades who attended 9 high schools in a diversely populated area of central Florida with 571 enrolled in the Career Academies and 571 enrolled in traditional classes. The 10th-grade FCAT scores served as the dependent variable. All students attended similar classes with similar content, making the primary variable the difference in academic gains between students participating in the Career Academy design and the traditional design classes. Using the Man-Whitney U Test resulted in the Career Academy group achieving the higher scores overall. This resulted in rejection of the first null-hypothesis. Further examination determined that the 10th-grade FCAT scores were greater for the average students group, which comprised the largest portion of the participant group, also resulted in rejection of the second null-hypothesis. The gifted and at-risk student group scores resulted in failure to reject the third and fourth null-hypotheses.

  16. New Members and Foreign Associates Elected to the National Academy of Sciences on May 2, 2000

    PubMed Central

    2000-01-01

    The Academy has elected 60 new members and 15 foreign associates from 9 countries in recognition of their distinguished and continuing achievements in original research. The election was held during the business session of the 137th annual meeting of the Academy. Election to membership in the Academy is considered one of the highest honors that can be accorded a U.S. scientist or engineer. Foreign associates are non-voting members of the Academy, with citizenship outside of the United States.

  17. Integrated synthesis of zeolites 4A and Na-P1 using coal fly ash for application in the formulation of detergents and swine wastewater treatment.

    PubMed

    Cardoso, Ariela M; Horn, Martha B; Ferret, Lizete S; Azevedo, Carla M N; Pires, Marçal

    2015-04-28

    Several researchers have reported zeolite synthesis using coal ash for a wide range of applications. However, little attention has been given to green processes, including moderate synthesis conditions, using waste as raw material and effluent reuse or reduction. In this study, Brazilian coal fly ashes were used for integrated synthesis of zeolites 4A and Na-P1 by two different routes and under moderate operating conditions (temperature and pressure). Both procedures produced zeolites with similar conversions (zeolite 4A at 82% purity and zeolite Na-P1 at 57-61%) and high CEC values (zeolites 4A: 4.5meqCa(2+)g(-1) and zeolites Na-P1: 2.6-2.8meqNH4(+)g(-1)). However, process 1 generated less effluent for the zeolite mass produced (7mLg(-1)), with low residual Si and Al levels and 74% of the Si available in the coal fly ash incorporated into the zeolite, while only 55% is used in process 2. For use as a builder in detergents, synthetic zeolite 4A exhibited conformity parameters equal to or greater than those of the commercial zeolite adopted as reference. Treatment of swine wastewater with zeolite Na-P1 resulted in a high removal capacity for total ammoniacal nitrogen (31mgg(-1)).

  18. A Study of Attrition of U.S. Coast Guard Academy Cadets and Junior Officers Who Are Academy Graduates.

    ERIC Educational Resources Information Center

    Enger, Isadore; And Others

    The objective was to improve procedures for selecting entrants with better potential for (a) completing the Coast Guard Academy and (b) remaining on active duty after graduation beyond the mandatory five-year period. Stepwise multiple regression was applied to the information on 10 instruments to develop equations for predicting graduation. Five…

  19. From the National Academies: A Tribute to the Science Education Legacy of National Academy of Sciences President Bruce Alberts

    ERIC Educational Resources Information Center

    Labov, Jay B.

    2005-01-01

    This column, "From the National Academies," was Bruce Alberts' idea, one of so many for improving education. As a long-standing member of the American Society for Cell Biology, the namesake for the prize that is awarded annually to cell biologists for excellence in science education, and one of the founding editors of this journal, Alberts…

  20. The Negotiation and Articulation of Identity, Position and Ethos in Joint Church Academies

    ERIC Educational Resources Information Center

    Green, Elizabeth

    2014-01-01

    This paper summarises the key findings of a research project into the identity, position and ethos of jointly sponsored church academies. The research sought to investigate how joint church academies are situated within the field, how they relate to existing academies and the maintained church school sector and how they articulate their vision and…

  1. 77 FR 49830 - Proposed Collection, Comments Requested: FBI National Academy Post-Course Questionnaire for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-17

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF JUSTICE Federal Bureau of Investigation Proposed Collection, Comments Requested: FBI National Academy Post-Course Questionnaire for Graduates and FBI National Academy Post- Course Questionnaire for Supervisors of Graduates; FBI National Academy Level...

  2. Diversity and the Success of Entering Classes at the U.S. Service Academies. Research Brief

    ERIC Educational Resources Information Center

    Kirby, Sheila Nataraj

    2010-01-01

    The United States Military Academy (USMA) at West Point, the United States Air Force Academy (USAFA) at Colorado Springs, and the United States Naval Academy (USNA) at Annapolis provide tuition-free, four-year undergraduate education and prepare entrants to be officers of the U.S. military services. Graduates are commissioned as officers for a…

  3. 76 FR 36933 - Board of Visitors for the National Fire Academy

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-23

    ... SECURITY Federal Emergency Management Agency Board of Visitors for the National Fire Academy AGENCY... Federal Advisory Committee Meeting. SUMMARY: The Board of Visitors for the National Fire Academy (Board... Board The purpose of the Board is to review annually the programs of the National Fire Academy...

  4. 78 FR 59045 - Board of Visitors for the National Fire Academy

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-25

    ... SECURITY Federal Emergency Management Agency Board of Visitors for the National Fire Academy AGENCY... Committee Meeting. SUMMARY: The Board of Visitors for the National Fire Academy (Board) will meet on October... or comments received by the National Fire Academy Board of Visitors, go to...

  5. 78 FR 25289 - Board of Visitors for the National Fire Academy Teleconference

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-30

    ... SECURITY Federal Emergency Management Agency Board of Visitors for the National Fire Academy Teleconference... Advisory Committee Teleconference. SUMMARY: The Board of Visitors for the National Fire Academy (Board...: The Board of Visitors for the National Fire Academy will meet on Wednesday, May 15, 2013, from 1:30...

  6. 76 FR 58028 - Board of Visitors for the National Fire Academy

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-19

    ... SECURITY Federal Emergency Management Agency Board of Visitors for the National Fire Academy AGENCY... Committee Meeting. SUMMARY: The Board of Visitors for the National Fire Academy (Board) will meet on October... Board The purpose of the Board is to review annually the programs of the National Fire Academy...

  7. 78 FR 72094 - Board of Visitors for the National Fire Academy

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-02

    ... SECURITY Federal Emergency Management Agency Board of Visitors for the National Fire Academy AGENCY... Committee Meeting. SUMMARY: The Board of Visitors for the National Fire Academy (Board) will meet on... or comments received by the National Fire Academy Board of Visitors, go to...

  8. 76 FR 6149 - National Fire Academy Board of Visitors; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-03

    ... SECURITY Federal Emergency Management Agency National Fire Academy Board of Visitors; Notice of Meeting... Advisory Committee Meeting. SUMMARY: The National Fire Academy Board of Visitors will meet on February 22... background documents or comments received by the National Fire Academy Board of Visitors, go to...

  9. 76 FR 5143 - Board of Visitors, United States Military Academy (USMA)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-28

    ... Department of the Army Board of Visitors, United States Military Academy (USMA) AGENCY: Department of the... States Military Academy Board of Visitors. This is the 2011 Organizational Meeting of the USMA Board of... States Military Academy Board of Visitors. 2. Date: Wednesday, February 16, 2011. ] 3. Time: 12...

  10. 76 FR 70980 - Meeting of the U.S. Naval Academy Board of Visitors

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-16

    ... Department of the Navy Meeting of the U.S. Naval Academy Board of Visitors AGENCY: Department of the Navy, DoD. ACTION: Notice of Partially Closed Meeting. SUMMARY: The U.S. Naval Academy Board of Visitors... Naval Academy. The executive session of this meeting from 11 a.m. to 12 p.m. on December 5, 2011,...

  11. 76 FR 27031 - Meeting of the U.S. Naval Academy Board of Visitors

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-10

    ... Department of the Navy Meeting of the U.S. Naval Academy Board of Visitors AGENCY: Department of the Navy, DoD. ACTION: Notice of Partially Closed Meeting. SUMMARY: The U.S. Naval Academy Board of Visitors... Naval Academy. The executive session of this meeting from 11 a.m. to 12 p.m. on June 6, 2011,...

  12. 77 FR 31591 - Meeting of the U.S. Naval Academy Board of Visitors

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-29

    ... Department of the Navy Meeting of the U.S. Naval Academy Board of Visitors AGENCY: Department of the Navy, DoD. ACTION: Notice of partially closed meeting. SUMMARY: The U.S. Naval Academy Board of Visitors... Naval Academy. The executive session of this meeting from 11:00 a.m. to 12:00 p.m. on June 11,...

  13. 76 FR 10341 - Meeting of the U.S. Naval Academy Board of Visitors

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-24

    ... Department of the Navy Meeting of the U.S. Naval Academy Board of Visitors AGENCY: Department of the Navy, DoD. ACTION: Notice of partially closed meeting. SUMMARY: The U.S. Naval Academy Board of Visitors... Naval Academy. The executive session of this meeting from 11 a.m. to 12 p.m. on March 7, 2011,...

  14. 75 FR 51247 - Meeting of the U.S. Naval Academy Board of Visitors

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-19

    ... Department of the Navy Meeting of the U.S. Naval Academy Board of Visitors AGENCY: Department of the Navy, DoD. ACTION: Notice of Partially Closed Meeting. SUMMARY: The U.S. Naval Academy Board of Visitors... Naval Academy. The executive session of this meeting from 11 a.m. to 12 p.m. on September 13, 2010,...

  15. 77 FR 65870 - Meeting of the U.S. Naval Academy Board of Visitors

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-31

    ... Department of the Navy Meeting of the U.S. Naval Academy Board of Visitors AGENCY: Department of the Navy, DoD. ACTION: Notice of partially closed meeting. SUMMARY: The U.S. Naval Academy Board of Visitors... Naval Academy. The executive session of this meeting from 11:00 a.m. to 12:00 p.m. on December 3,...

  16. 75 FR 18167 - Meeting of the U.S. Naval Academy Board of Visitors

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-09

    ... Department of the Navy Meeting of the U.S. Naval Academy Board of Visitors AGENCY: Department of the Navy, DoD. ACTION: Notice of partially closed meeting. SUMMARY: The U.S. Naval Academy Board of Visitors... Naval Academy. The executive session of this meeting from 11 a.m. to 12 p.m. on June 28, 2010,...

  17. 78 FR 5424 - Meeting of the U.S. Naval Academy Board of Visitors

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-25

    ... Department of the Navy Meeting of the U.S. Naval Academy Board of Visitors AGENCY: Department of the Navy, DoD. ACTION: Notice of Partially Closed Meeting. SUMMARY: The U.S. Naval Academy Board of Visitors... Naval Academy. The executive session of this meeting from 11:00 a.m. to 12:00 p.m. on March 4,...

  18. 78 FR 53430 - Meeting of the U.S. Naval Academy Board of Visitors

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-29

    ... Department of the Navy Meeting of the U.S. Naval Academy Board of Visitors AGENCY: Department of the Navy, DoD. ACTION: Notice of partially closed meeting. SUMMARY: The U.S. Naval Academy Board of Visitors... Naval Academy. The executive session of this meeting from 11:00 a.m. to 12:00 p.m. on September 30,...

  19. 78 FR 29124 - Meeting of the U.S. Naval Academy Board of Visitors

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-17

    ... Department of the Navy Meeting of the U.S. Naval Academy Board of Visitors AGENCY: Department of the Navy, DoD. ACTION: Notice of partially closed meeting. SUMMARY: The United States Naval Academy Board of... Naval Academy. The executive session of this meeting from 11:00 a.m. to 12:00 p.m. on June 3, 2013,...

  20. 76 FR 54223 - Meeting of the U.S. Naval Academy Board of Visitors

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-31

    ... Department of the Navy Meeting of the U.S. Naval Academy Board of Visitors AGENCY: Department of the Navy, DoD. ACTION: Notice of partially closed meeting. SUMMARY: The U.S. Naval Academy Board of Visitors... Naval Academy. The executive session of this meeting from 11 a.m. to 12 p.m. on September 19, 2011,...

  1. 75 FR 68773 - Meeting of the U.S. Naval Academy Board of Visitors

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-09

    ... Department of the Navy Meeting of the U.S. Naval Academy Board of Visitors AGENCY: Department of the Navy, DoD. ACTION: Notice of partially closed meeting. SUMMARY: The U.S. Naval Academy Board of Visitors... Naval Academy. The executive session of this meeting from 11 a.m. to 12 p.m. on December 6, 2010,...

  2. The Politics of the Academies Programme: Natality and Pluralism in Education Policy-Making

    ERIC Educational Resources Information Center

    Gunter, Helen M.; McGinity, Ruth

    2014-01-01

    Our investigations into the politics of the Academies Programme in England have generated thinking that draws on data about the conversion process from two projects. We engage with an early City Academy that replaced two "failing" schools, and a recent Academy that replaced a "successful" high school. We deploy Hannah…

  3. The American Academy of Kinesiology and Physical Education, 1940-1984: Innovation, Introspection, Identity, and Involvement

    ERIC Educational Resources Information Center

    Jable, J. Thomas

    2006-01-01

    In 2005, the American Academy of Kinesiology and Physical Education reached its 75th anniversary. In celebration of this momentous occasion, this paper examines 44 years of the Academy's history from 1940 to 1984. During the 1940s, the Academy was engaged in the war effort. Then in the 1950s, it sought to define more precisely its role and…

  4. Commitment to Liberal Education at the United States Air Force Academy

    ERIC Educational Resources Information Center

    Enger, Rolf C.; Jones, Steven K.; Born, Dana H.

    2010-01-01

    Located just north of Colorado Springs, Colorado, the United States Air Force Academy (USAFA) is one of the nation's federally funded military service academies. With an enrollment of approximately 4,400 undergraduates, the academy offers an integrated four-year curriculum of academics, athletics, leadership and character development, military…

  5. "I Love My Work, but This Is Not My Life": Women of Color in the Academy

    ERIC Educational Resources Information Center

    Mena, Jasmine A.

    2016-01-01

    The present study used critical ethnography and intersectionality theory to better understand the experiences of Women of Color (WOC) in the academy. WOC experience numerous and significant challenges in the academy that have the potential to stifle their career growth. Claiming increased acceptance and diversity in the academy without a…

  6. Academies: It's Time to Learn the Lessons. NFER Thinks: What the Evidence Tells Us

    ERIC Educational Resources Information Center

    Worth, Jack

    2015-01-01

    Academies are now a part of the English school landscape. Future policy should focus on learning the lessons from the growth of academy schools. In this "NFER Thinks," the author presents the case that any future expansion in the number of academies should be motivated by a clear vision of the long-term outcomes for learners that…

  7. Long-Term Single and Joint Effects of Excessive Daytime Napping on the HOMA-IR Index and Glycosylated Hemoglobin: A Prospective Cohort Study.

    PubMed

    Li, Xue; Pang, Xiuyu; Zhang, Qiao; Qu, Qiannuo; Hou, Zhigang; Liu, Zhipeng; Lv, Lin; Na, Guanqiong; Zhang, Wei; Sun, Changhao; Li, Ying

    2016-02-01

    This prospective cohort study was conducted to assess the duration of daytime napping and its effect combined with night sleep deprivation on the risk of developing high HOMA-IR (homeostasis model assessment of insulin resistance) index and disadvantageous changes in glycosylated hemoglobin (HbA1c) levels.A total of 5845 diabetes-free subjects (2736 women and 3109 men), 30 to 65 years of age, were targeted for this cohort study since 2008. Multiple adjusted Cox regression models were performed to evaluate the single and joint effects of daytime napping on the risk of an elevated HbA1c level and high HOMA-IR index.After an average of 4.5 years of follow-up, >30 minutes of daytime napping was significantly associated with an increased risk of an elevated HbA1c level (>6.5%) in men and women (all P trend < 0.05). Hazard ratios (HRs) for an HbA1c level between 5.7% and 6.4% were also significant in the entire cohort and women, but nonsignificant in men. HRs (95% confidence interval, CIs) for the high HOMA-IR index in the entire cohort, men, and women were 1.33 (1.10-1.62), 1.46 (1.08-1.98), and 1.47 (1.12-1.91), respectively. The combination of sleep deprivation with no naps or >30 minutes napping and the combination of no sleep deprivation with >30 minutes daytime napping were all associated with an HbA1c level >6.5% (HR = 2.08, 95% CI = 1.24-3.51; HR = 4.00, 95% CI = 2.03-7.90; and HR = 2.05, 95% CI = 1.29-3.27, respectively). No sleep deprivation combined with >30 minutes daytime napping correlated with a high risk of an HbA1c level between 5.7% and 6.4% and high HOMA-IR index (HR = 2.12, 95% CI = 1.48-3.02; and HR = 1.35, 95% CI = 1.10-1.65, respectively).Daytime napping >30 minutes was associated with a high risk of an elevated HbA1c level and high HOMA-IR index. No sleep deprivation combined with napping >30 minutes carries a risk of abnormal glucose metabolism. Sleep deprivation combined with brief daytime napping <30

  8. Long-Term Single and Joint Effects of Excessive Daytime Napping on the HOMA-IR Index and Glycosylated Hemoglobin: A Prospective Cohort Study.

    PubMed

    Li, Xue; Pang, Xiuyu; Zhang, Qiao; Qu, Qiannuo; Hou, Zhigang; Liu, Zhipeng; Lv, Lin; Na, Guanqiong; Zhang, Wei; Sun, Changhao; Li, Ying

    2016-02-01

    This prospective cohort study was conducted to assess the duration of daytime napping and its effect combined with night sleep deprivation on the risk of developing high HOMA-IR (homeostasis model assessment of insulin resistance) index and disadvantageous changes in glycosylated hemoglobin (HbA1c) levels.A total of 5845 diabetes-free subjects (2736 women and 3109 men), 30 to 65 years of age, were targeted for this cohort study since 2008. Multiple adjusted Cox regression models were performed to evaluate the single and joint effects of daytime napping on the risk of an elevated HbA1c level and high HOMA-IR index.After an average of 4.5 years of follow-up, >30 minutes of daytime napping was significantly associated with an increased risk of an elevated HbA1c level (>6.5%) in men and women (all P trend < 0.05). Hazard ratios (HRs) for an HbA1c level between 5.7% and 6.4% were also significant in the entire cohort and women, but nonsignificant in men. HRs (95% confidence interval, CIs) for the high HOMA-IR index in the entire cohort, men, and women were 1.33 (1.10-1.62), 1.46 (1.08-1.98), and 1.47 (1.12-1.91), respectively. The combination of sleep deprivation with no naps or >30 minutes napping and the combination of no sleep deprivation with >30 minutes daytime napping were all associated with an HbA1c level >6.5% (HR = 2.08, 95% CI = 1.24-3.51; HR = 4.00, 95% CI = 2.03-7.90; and HR = 2.05, 95% CI = 1.29-3.27, respectively). No sleep deprivation combined with >30 minutes daytime napping correlated with a high risk of an HbA1c level between 5.7% and 6.4% and high HOMA-IR index (HR = 2.12, 95% CI = 1.48-3.02; and HR = 1.35, 95% CI = 1.10-1.65, respectively).Daytime napping >30 minutes was associated with a high risk of an elevated HbA1c level and high HOMA-IR index. No sleep deprivation combined with napping >30 minutes carries a risk of abnormal glucose metabolism. Sleep deprivation combined with brief daytime napping <30

  9. Aerial view of the Press Site

    NASA Technical Reports Server (NTRS)

    1998-01-01

    In this aerial view, The News Center sits beyond a large parking lot, on a hill at the northeastern end of the Launch Complex 39 Area , next to the turn basin (at left). From left, the grandstand faces the launch pads several miles away on the Atlantic seashore; behind it, the television studio is the site of media conferences; next, the large white-roofed building is the hub of information and activity for press representatives. Lined up on the right of the Press Site are various buildings and trailers, home to major news networks. The parking lot can accommodate the hundreds of media personnel who attend Space Shuttle launches.

  10. Study of resonant scattering of 21Na+p relevant to astrophysical 18Ne(α,p)21Na reaction

    NASA Astrophysics Data System (ADS)

    He, J. J.; Zhang, L. Y.; Xu, S. W.; Chen, S. Z.; Hu, J.; Ma, P.; Chen, R. F.; Yamaguchi, H.; Kubono, S.; Hashimoto, T.; Kahl, D.; Hayakawa, S.; Wakabayashi, Y.; Togano, Y.; Wang, H. W.; Tian, W. D.; Guo, B.; Teranishi, T.; Iwasa, N.; Yamada, T.; Komatsubara, T.

    2012-11-01

    Astrophysical 18Ne(α,p)21Na reaction is one of the most probable breakout routes, which lead to the rp-process from the hot-CNO cycle, converting the initial CNO elements into heavier elements in Type I x-ray bursters. Presently, there is no much experimental cross-section data reported at the energy of astrophysical interest, and resonant spectroscopic information in compound 22Mg is scarce as well. The experiment has been carried out by using the CNS radioactive ion beam separator (CRIB). Resonant properties in 22Mg have been studied via the resonant elastic scattering of 21Na+p, and cross section of the time-reversal reaction of 21Na(p,α)18Ne been measured simultaneously. A wide excitation energy region up to Ex ~ 9.5 MeV in 22Mg has been scanned with a thick-target method. Some preliminary results will be reported.

  11. Simulator investigations of side-stick controller/stability and control augmentation systems for night nap-of-earth flight

    NASA Technical Reports Server (NTRS)

    Landis, K. H.; Aiken, E. W.

    1984-01-01

    Several night nap-of-the-earth mission tasks were evaluated using a helmet-mounted display which provided a limited field-of-view image with superimposed flight control symbology. A wide range of stability and control augmentation designs was investigated. Variations in controller force-deflection characteristics and the number of axes controlled through an integrated side-stick controller were studied. In general, a small displacement controller is preferred over a stiffstick controller particularly for maneuvering flight. Higher levels of stability augmentation were required for IMC tasks to provide handling qualities comparable to those achieved for the same tasks conducted under simulated visual flight conditions. Previously announced in STAR as N82-23216

  12. Multicenter Approach to Recurrent Acute and Chronic Pancreatitis in the United States: The North American Pancreatitis Study 2 (NAPS2)

    PubMed Central

    Whitcomb, David C.; Yadav, Dhiraj; Adam, Slivka; Hawes, Robert H.; Brand, Randall E.; Anderson, Michelle A.; Money, Mary E.; Banks, Peter A.; Bishop, Michele D.; Baillie, John; Sherman, Stuart; DiSario, James; Burton, Frank R.; Gardner, Timothy B.; Amann, Stephen T.; Gelrud, Andres; Lo, Simon K.; DeMeo, Mark T.; Steinberg, William M.; Kochman, Michael L.; Etemad, Babak; Forsmark, Christopher E.; Elinoff, Beth; Greer, Julia B.; O’Connell, Michael; Lamb, Janette; Barmada, M. Michael

    2008-01-01

    Background Recurrent acute pancreatitis (RAP) and chronic pancreatitis (CP) are complex syndromes associated with numerous etiologies, clinical variables and complications. We developed the North American Pancreatitis Study 2 (NAPS2) to be sufficiently powered to understand the complex environmental, metabolic and genetic mechanisms underlying RAP and CP. Methods Between August 2000 and September 2006, a consortium of 20 expert academic and private sites prospectively ascertained 1,000 human subjects with RAP or CP, plus 695 controls (spouse, family, friend or unrelated). Standardized questionnaires were completed by both the physicians and study subjects and blood was drawn for genomic DNA and biomarker studies. All data were double-entered into a database and systematically reviewed to minimize errors and include missing data. Results A total of 1,000 subjects (460 RAP, 540 CP) and 695 controls who completed consent forms and questionnaires and donated blood samples comprised the final dataset. Data were organized according to diagnosis, supporting documentation, etiological classification, clinical signs and symptoms (including pain patterns and duration, and quality of life), past medical history, family history, environmental exposures (including alcohol and tobacco use), medication use and therapeutic interventions. Upon achieving the target enrollment, data were organized and classified to facilitate future analysis. The approaches, rationale and datasets are described, along with final demographic results. Conclusion The NAPS2 consortium has successfully completed a prospective ascertainment of 1,000 subjects with RAP and CP from the USA. These data will be useful in elucidating the environmental, metabolic and genetic conditions, and to investigate the complex interactions that underlie RAP and CP. PMID:18765957

  13. [RELATIONS BETWEEN STANISŁAW ESTREICHER AND THE ACADEMY OF ARTS AND SCIENCES AND THE POLISH ACADEMY OF ARTS AND SCIENCES (IN THE LIGHT OF ITS FILES)].

    PubMed

    Skrzyński, Tomasz

    2015-01-01

    Stanisław Estreicher, member of the Estreicher family, which rendered great service to Polish science and culture, was one of the most prominent Polish researchers in the history of law and vice-chancellor of the Jagiellonian University. This future professor for the first time appeared in the files of the Academy already in 1888. In 1914 he was elected associate member and in 1930--full member of the Academy. Because of his diverse interests, Estreicher's activity in the Academy included, i.a., his involvement with the Academy's authorities and the Department of History and Philosophy, his work dealing with general publications of the Academy, publishing his own writings and source editions, activity on the forums of six commissions, representing the Academy and giving opinions on scientific works to be published by the Academy. His involvement in the Academy was growing but these ties did not dominate his diverse activities. From the point of view of the Academy, the most of important was Professor Estreicher's participation in general publications' issues and his increasing influence on the institution's authorities, on the Department of History and Philosophy and the Legal Committee. On the other hand, from the point of view of Professor Estreicher himself, the most significant was "Polish Bibliography". PMID:26455001

  14. [RELATIONS BETWEEN STANISŁAW ESTREICHER AND THE ACADEMY OF ARTS AND SCIENCES AND THE POLISH ACADEMY OF ARTS AND SCIENCES (IN THE LIGHT OF ITS FILES)].

    PubMed

    Skrzyński, Tomasz

    2015-01-01

    Stanisław Estreicher, member of the Estreicher family, which rendered great service to Polish science and culture, was one of the most prominent Polish researchers in the history of law and vice-chancellor of the Jagiellonian University. This future professor for the first time appeared in the files of the Academy already in 1888. In 1914 he was elected associate member and in 1930--full member of the Academy. Because of his diverse interests, Estreicher's activity in the Academy included, i.a., his involvement with the Academy's authorities and the Department of History and Philosophy, his work dealing with general publications of the Academy, publishing his own writings and source editions, activity on the forums of six commissions, representing the Academy and giving opinions on scientific works to be published by the Academy. His involvement in the Academy was growing but these ties did not dominate his diverse activities. From the point of view of the Academy, the most of important was Professor Estreicher's participation in general publications' issues and his increasing influence on the institution's authorities, on the Department of History and Philosophy and the Legal Committee. On the other hand, from the point of view of Professor Estreicher himself, the most significant was "Polish Bibliography".

  15. Predicting the performance of belt filter presses using the Crown Press for laboratory simulation

    SciTech Connect

    Graham, T.M.

    1999-07-26

    Belt filter presses (BFPs) are among the most commonly used devices to dewater wastewater sludge. The concept used by a BFP to achieve dewatered cake solids is relatively simple; however, replicating this performance in the laboratory in order to predict the performance of a BFP with reasonable reliability has proven to be a challenge. The Crown Press is one tool that has been shown to replicate the performance of anaerobically digested sludge on a BFP. This study used the Crown Press to replicate and predict the performance of waste activated sludge (WAS) from the Mauldin Road wastewater treatment plant on BFPs. Several operational variables, including belt speed, belt tension, polymer type, and polymer dose, were changed on the Crown Press to predict how the changes on the BFP would affect performance. Two polymers were chosen to be tested on the BFPs at Mauldin Road based on Crown Press predictions. The first polymer performed the same as the plant`s current polymer in the lab, and the second performed better (achieved higher final cake solids) than the current polymer. These predictions were borne out in the BFP tests, showing that the Crown Press predictions were accurate. The Crown Press predictions were also compared to the predictions made by the capillary suction time (CST) and specific resistance to filtration (SRF) tests. The Crown Press provided more information regarding the affect of polymer type and dose on cake solids than either CST or SRF. The Crown Press was shown to be a viable tool to assess potential changes in BFP performance with WAS when operational variables change.

  16. Fnr-, NarP- and NarL-dependent regulation of transcription initiation from the Haemophilus influenzae Rd napF (periplasmic nitrate reductase) promoter in Escherichia coli K-12.

    PubMed

    Stewart, Valley; Bledsoe, Peggy J

    2005-10-01

    Periplasmic nitrate reductase (napFDAGHBC operon product) functions in anaerobic respiration. Transcription initiation from the Escherichia coli napF operon control region is activated by the Fnr protein in response to anaerobiosis and by the NarQ-NarP two-component regulatory system in response to nitrate or nitrite. The binding sites for the Fnr and phospho-NarP proteins are centered at positions -64.5 and -44.5, respectively, with respect to the major transcription initiation point. The E. coli napF operon is a rare example of a class I Fnr-activated transcriptional control region, in which the Fnr protein binding site is located upstream of position -60. To broaden our understanding of napF operon transcriptional control, we studied the Haemophilus influenzae Rd napF operon control region, expressed as a napF-lacZ operon fusion in the surrogate host E. coli. Mutational analysis demonstrated that expression required binding sites for the Fnr and phospho-NarP proteins centered at positions -81.5 and -42.5, respectively. Transcription from the E. coli napF operon control region is activated by phospho-NarP but antagonized by the orthologous protein, phospho-NarL. By contrast, expression from the H. influenzae napF-lacZ operon fusion in E. coli was stimulated equally well by nitrate in both narP and narL null mutants, indicating that phospho-NarL and -NarP are equally effective regulators of this promoter. Overall, the H. influenzae napF operon control region provides a relatively simple model for studying synergistic transcription by the Fnr and phospho-NarP proteins acting from class I and class II locations, respectively.

  17. Financial Operations of the Five Service Academies: Department of Defense, Department of Transportation, Department of Commerce. Report to the Congress by the Comptroller General of the United States.

    ERIC Educational Resources Information Center

    Comptroller General of the U.S., Washington, DC.

    This is the first report of the review of operations of five service academies operated by the government: U.S. Military Academy, West Point, New York; Naval Academy, Annapolis, Maryland; Air Force Academy, Colorado Springs, Colorado; Coast Guard Academy, New London, Connecticut; and Merchant Marine Academy, Kings Point, New York. This report…

  18. A Journalist's Guide to the Free Press.

    ERIC Educational Resources Information Center

    Ingelhart, Louis

    1996-01-01

    Summarizes the content of the federal constitution and various state constitutions regarding freedom of the press. Examines certain borderline issues, including actions and expressions, pornography, defamation, libel, and copyrighted material. States that regulation of unprotected material must be reasonable, specific, and clear. Discusses what…

  19. Press Site Auditorium dedicated to John Holliman

    NASA Technical Reports Server (NTRS)

    1999-01-01

    A ceremony dedicated the KSC Press Site auditorium as the John Holliman Auditorium to honor the correspondent for his enthusiastic, dedicated coverage of America's space program. The auditorium was built in 1980 and has been the focal point for new coverage of Space Shuttle launches. The ceremony followed the 94th launch of a Space Shuttle, on mission STS-96, earlier this morning.

  20. Neo-Lysenkoism, IQ, and the Press.

    ERIC Educational Resources Information Center

    Davis, Bernard D.

    1983-01-01

    In "The Mismeasure of Man," a history of efforts to measure intelligence, Stephen Jay Gould is highly selective in his account, and tests for scientific truth by the standards of his own social and political convictions. Specifically, to combat racist approaches to theories of intelligence, Gould presses for equal and opposite bias. (Author/GC)