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Sample records for academy press nap

  1. NATIONAL ACADEMY PRESS WEB SITE

    EPA Science Inventory

    The National Academy Press is the publisher for the National Academy of Sciences, the National Academy of Engineering, the Institute of Medicine, and the National Research Council. Through this web site, you have access to a virtual treasure trove of books, reports and publicatio...

  2. The Flight from Reason. Essays on Intellectual Freedom in the Academy, the Press, and the Library.

    ERIC Educational Resources Information Center

    Berninghausen, David K.

    David K. Berninghousen's writings on intellectual freedom in the library, the university, and the press are collected in this volume. These essays cover the education of librarians for intellectual freedom, the communications process, the threat to liberal values (intellectualism, objectivity) in the communications institutions, the erosion of…

  3. Naps (For Parents)

    MedlinePlus

    ... KidsHealth in the Classroom What Other Parents Are Reading Upsetting News Reports? What to Say Vaccines: Which Ones ... Text Size What's in this article? The Importance of Naps Sleep Needs by Age Signs of ...

  4. NAPS-MS

    PubMed Central

    Gudesblatt, Mark; Kresa-Reahl, Kiren; Brandes, David W.; Sater, Pamela

    2016-01-01

    Background: Patients with multiple sclerosis (MS) have higher rates of fatigue, mood disturbance, and cognitive impairments than healthy populations. Disease-modifying agents may affect sleep. Although patients taking natalizumab often show improvement in fatigue during the first year of therapy, the mechanism behind this effect is unknown. The aim of the NAPS-MS study was to investigate whether natalizumab affected objective measures of sleep as determined by polysomnography (PSG) and multiple sleep latency testing (MSLT) in patients with MS with fatigue or sleepiness initiating therapy. Additional goals were to evaluate changes in measures of fatigue, mood, and cognition and to correlate these measures with objective sleep measures. Methods: Patients underwent PSG and MSLT before their first natalizumab infusion and after their seventh. Patients completed the Modified Fatigue Impact Scale, Fatigue Severity Scale (FSS), Epworth Sleepiness Scale (ESS), and visual analogue scale for fatigue (VAS-F) at their first, fourth, and seventh natalizumab infusions. NeuroTrax cognitive tests and the Hospital Anxiety and Depression Scale (HADS) were performed at the first and seventh natalizumab infusions. Results: Changes in sleep efficiency, wakefulness after sleep onset, and multiple sleep latency from baseline to 6 months of therapy did not reach significance. The FSS, VAS-F, ESS, and HADS scores were significantly improved after 6 months of therapy; cognitive scores were not significantly improved. Conclusions: Although treatment with natalizumab was associated with improvements in fatigue, sleepiness, and mood, changes in objective measures of sleep were not significant. PMID:27551242

  5. Alertness management in flight operations - Strategic napping

    NASA Technical Reports Server (NTRS)

    Rosekind, Mark R.; Gander, Philippa H.; Dinges, David F.

    1991-01-01

    Strategic napping in two different flight operation environments is considered to illustrate its application as a fatigue countermeasure. Data obtained from commercial short-haul and long-haul operations demonstrated the utility and current practices of strategic napping. A preplanned cockpit nap acted as an acute 'safety valve' for the sleep loss, circadian disruption, and fatigue that occurs in long-haul flying.

  6. Peninsula Academies.

    ERIC Educational Resources Information Center

    Raby, Marilyn E.

    1984-01-01

    Describes the Peninsula Academies program developed by the Sequoia (California) Union High School District and 27 local high technology companies to help educationally disadvantaged students break the pattern of low academic achievement, lack of skills, and chronic unemployment. (FL)

  7. The effects of napping on cognitive functioning.

    PubMed

    Lovato, Nicole; Lack, Leon

    2010-01-01

    Naps (brief sleeps) are a global and highly prevalent phenomenon, thus warranting consideration for their effects on cognitive functioning. Naps can reduce sleepiness and improve cognitive performance. The benefits of brief (5-15 min) naps are almost immediate after the nap and last a limited period (1-3h). Longer naps (> 30 min) can produce impairment from sleep inertia for a short period after waking but then produce improved cognitive performance for a longer period (up to many hours). Other factors that affect the benefits from the nap are the circadian timing of the nap with early afternoon being the most favourable time. Longer periods of prior wakefulness favour longer naps over brief naps. Those who regularly nap seem to show greater benefits than those who rarely nap. These conclusions, however, need to be accepted cautiously until more comprehensive research programmes are conducted in which all these parameters are varied. Research is also needed to test the benefits of brief naps taken more naturalistically at the time when sleepiness becomes intrusive. The significant benefits of a brief nap, containing virtually no slow wave EEG activity, are not predicted by the present theory of homeostatic sleep drive (Process S). A new biological process (Process O) suggests that sleep onset followed by only 7-10 min of sleep can result in a substantial increase of alertness because it allows the rapid dissipation of inhibition in the 'wake-active' cells associated with the 'sleep-switch' mechanism rather than the dissipation of Process S. PMID:21075238

  8. Academy Rewards.

    ERIC Educational Resources Information Center

    Schnitzer, Denise K.

    2003-01-01

    Granby High School in Norfolk, Virginia, is a large comprehensive high school restructured into four smaller academies that allow students a more personal learning environment. Positive growth is shown in test scores, dropout rates, and the narrowing achievement gap between minority and majority students. (MLF)

  9. NAP (davunetide) provides functional and structural neuroprotection.

    PubMed

    Gozes, Illana

    2011-01-01

    NAP (davunetide) is an eight amino acid peptide (NAPVSIPQ) that has been shown to provide potent neuroprotection, in vitro and in vivo. In human clinical trials, NAP has been shown to increase memory scores in patients suffering from amnestic mild cognitive impairment, a precursor to Alzheimer's disease and to enhance functional daily behaviors in schizophrenia patients. NAP is derived from activity-dependent neuroprotective protein (ADNP) a molecule that is essential for brain formation, interacting with chromatin associated protein alpha and the chromatin remodeling complex SWI/SNF and regulating >400 genes during embryonic development. Partial loss in ADNP results in cognitive deficits and pathology of the microtubule associated protein tau (tauopathy) that is ameliorated in part by NAP replacement therapy. Recent studies increased the scope of NAP neuroprotection and provided further insights into the NAP mechanisms of action. Thus, it has been hypothesized that the presence of tau on axonal microtubules renders them notably less sensitive to the microtubule-severing protein katanin, and NAP was shown to protect microtubules from katanin disruption in the face of reduced tau expression. Parallel studies showed that NAP reduced the number of apoptotic neurons through activation of PI-3K/Akt pathway in the cortical plate or both PI-3K/Akt and MAPK/MEK1 kinases in the white matter. The interaction of these disparate yet complementary pathways is the subject of future studies toward human brain neuroprotection in the clinical scenario. PMID:21524250

  10. Daytime nap controls toddlers' nighttime sleep.

    PubMed

    Nakagawa, Machiko; Ohta, Hidenobu; Nagaoki, Yuko; Shimabukuro, Rinshu; Asaka, Yoko; Takahashi, Noriko; Nakazawa, Takayo; Kaneshi, Yousuke; Morioka, Keita; Oishi, Yoshihisa; Azami, Yuriko; Ikeuchi, Mari; Takahashi, Mari; Hirata, Michio; Ozawa, Miwa; Cho, Kazutoshi; Kusakawa, Isao; Yoda, Hitoshi

    2016-01-01

    Previous studies have demonstrated that afternoon naps can have a negative effect on subsequent nighttime sleep in children. These studies have mainly been based on sleep questionnaires completed by parents. To investigate the effect of napping on such aspects of sleep quality, we performed a study in which child activity and sleep levels were recorded using actigraphy. The parents were asked to attach actigraphy units to their child's waist by an adjustable elastic belt and complete a sleep diary for 7 consecutive days. 50 healthy young toddlers of approximately 1.5 years of age were recruited. There was a significant negative correlation between nap duration and both nighttime sleep duration and sleep onset time, suggesting that long nap sleep induces short nighttime sleep duration and late sleep onset time. We also found a significant negative correlation between nap timing and nighttime sleep duration and also a significant positive correlation between nap timing and sleep onset time, suggesting that naps in the late afternoon also lead to short nighttime sleep duration and late sleep onset. Our findings suggest that duration-controlled naps starting early in the afternoon can induce a longer nighttime sleep in full-term infants of approximately 1.5 years of age. PMID:27277329

  11. Daytime nap controls toddlers’ nighttime sleep

    PubMed Central

    Nakagawa, Machiko; Ohta, Hidenobu; Nagaoki, Yuko; Shimabukuro, Rinshu; Asaka, Yoko; Takahashi, Noriko; Nakazawa, Takayo; Kaneshi, Yousuke; Morioka, Keita; Oishi, Yoshihisa; Azami, Yuriko; Ikeuchi, Mari; Takahashi, Mari; Hirata, Michio; Ozawa, Miwa; Cho, Kazutoshi; Kusakawa, Isao; Yoda, Hitoshi

    2016-01-01

    Previous studies have demonstrated that afternoon naps can have a negative effect on subsequent nighttime sleep in children. These studies have mainly been based on sleep questionnaires completed by parents. To investigate the effect of napping on such aspects of sleep quality, we performed a study in which child activity and sleep levels were recorded using actigraphy. The parents were asked to attach actigraphy units to their child’s waist by an adjustable elastic belt and complete a sleep diary for 7 consecutive days. 50 healthy young toddlers of approximately 1.5 years of age were recruited. There was a significant negative correlation between nap duration and both nighttime sleep duration and sleep onset time, suggesting that long nap sleep induces short nighttime sleep duration and late sleep onset time. We also found a significant negative correlation between nap timing and nighttime sleep duration and also a significant positive correlation between nap timing and sleep onset time, suggesting that naps in the late afternoon also lead to short nighttime sleep duration and late sleep onset. Our findings suggest that duration-controlled naps starting early in the afternoon can induce a longer nighttime sleep in full-term infants of approximately 1.5 years of age. PMID:27277329

  12. Daydreams and nap dreams: Content comparisons.

    PubMed

    Carr, Michelle; Nielsen, Tore

    2015-11-01

    Differences between nighttime REM and NREM dreams are well-established but only rarely are daytime REM and NREM nap dreams compared with each other or with daydreams. Fifty-one participants took daytime naps (with REM or NREM awakenings) and provided both waking daydream and nap dream reports. They also provided ratings of their bizarreness, sensory experience, and emotion intensity. Recall rates for REM (96%) and NREM (89%) naps were elevated compared to typical recall rates for nighttime dreams (80% and 43% respectively), suggesting an enhanced circadian influence. All attribute ratings were higher for REM than for NREM dreams, replicating findings for nighttime dreams. Compared with daydreams, NREM dreams had lower ratings for emotional intensity and sensory experience while REM dreams had higher ratings for bizarreness and sensory experience. Results support using daytime naps in dream research and suggest that there occurs selective enhancement and inhibition of specific dream attributes by REM, NREM and waking state mechanisms. PMID:26164253

  13. America's Service Academies, Your Service Academies

    ERIC Educational Resources Information Center

    Born, Dana H.; Phillips, Andrew T.; Trainor, Timothy E.

    2012-01-01

    The United States Air Force Academy, United States Naval Academy, and United States Military Academy are America's three largest service academies. They are "the" primary undergraduate institutions and commissioning sources that educate and develop the officers who are expected to lead this nation's armed forces. They are special places that have…

  14. A novel NAP member GhNAP is involved in leaf senescence in Gossypium hirsutum

    PubMed Central

    Fan, Kai; Bibi, Noreen; Gan, Susheng; Li, Feng; Yuan, Shuna; Ni, Mi; Wang, Ming; Shen, Hao; Wang, Xuede

    2015-01-01

    Premature leaf senescence has a negative influence on the yield and quality of cotton, and several genes have been found to regulate leaf senescence. Howeer, many underlying transcription factors are yet to be identified. In this study, a NAP-like transcription factor (GhNAP) was isolated from Gossypium hirsutum. GhNAP has the typical NAC structure and a conserved novel subdomain in its divergent transcription activation region (TAR). GhNAP was demonstrated to be a nuclear protein, and it showed transcriptional activation activity in yeast. Furthermore, the expression of GhNAP was closely associated with leaf senescence. GhNAP could rescue the delayed-senescence phenotype of the atnap null mutant. Overexpression of GhNAP could cause precocious senescence in Arabidopsis. However, down-regulation of GhNAP delayed leaf senescence in cotton, and affected cotton yield and its fibre quality. Moreover, the expression of GhNAP can be induced by abscisic acid (ABA), and the delayed leaf senescence phenotype in GhNAPi plants might be caused by the decreased ABA level and reduced expression level of ABA-responsive genes. All of the results suggested that GhNAP could regulate the leaf senescence via the ABA-mediated pathways and was further related to the yield and quality in cotton. PMID:25991739

  15. The Timing of the Circadian Clock and Sleep Differ between Napping and Non-Napping Toddlers.

    PubMed

    Akacem, Lameese D; Simpkin, Charles T; Carskadon, Mary A; Wright, Kenneth P; Jenni, Oskar G; Achermann, Peter; LeBourgeois, Monique K

    2015-01-01

    The timing of the internal circadian clock shows large inter-individual variability across the lifespan. Although the sleep-wakefulness pattern of most toddlers includes an afternoon nap, the association between napping and circadian phase in early childhood remains unexplored. This study examined differences in circadian phase and sleep between napping and non-napping toddlers. Data were collected on 20 toddlers (34.2±2.0 months; 12 females; 15 nappers). Children followed their habitual napping and non-napping sleep schedules (monitored with actigraphy) for 5 days before an in-home salivary dim light melatonin onset (DLMO) assessment. On average, napping children fell asleep during their nap opportunities on 3.6±1.2 of the 5 days before the DLMO assessment. For these napping children, melatonin onset time was 38 min later (p = 0.044; d = 0.93), actigraphically-estimated bedtime was 43 min later (p = 0.014; d = 1.24), sleep onset time was 59 min later (p = 0.006; d = 1.46), and sleep onset latency was 16 min longer (p = 0.030; d = 1.03) than those not napping. Midsleep and wake time did not differ by napping status. No difference was observed in the bedtime, sleep onset, or midsleep phase relationships with DLMO; however, the wake time phase difference was 47 min smaller for napping toddlers (p = 0.029; d = 1.23). On average, nappers had 69 min shorter nighttime sleep durations (p = 0.006; d = 1.47) and spent 49 min less time in bed (p = 0.019; d = 1.16) than non-nappers. Number of days napping was correlated with melatonin onset time (r = 0.49; p = 0.014). Our findings indicate that napping influences individual variability in melatonin onset time in early childhood. The delayed bedtimes of napping toddlers likely permits light exposure later in the evening, thereby delaying the timing of the clock and sleep. Whether the early developmental trajectory of circadian phase involves an advance associated with the decline in napping is a question necessitating

  16. [Profile of the elderly who naps].

    PubMed

    dos Santos, Ariene Angelini; de Oliveira, Simone Camargo; Freitas, Denise Cuoghi de Carvalho Veríssimo; Ceolim, Maria Filomena; Pavarini, Sofia Cristina Iost; da Rocha, Maria Cecília Pires

    2013-12-01

    This study aimed to characterize the elderly who naps according to sociodemographic characteristics and frailty. A descriptive, cross-sectional study part of the multicenter project Frailty in the Elderly Brazilians. We evaluated 1,866 elderly people using a sociodemographic questionnaire. The frailty was assessed using the phenotype proposed by Fried. The data were analyzed with descriptive statistics. The results showed that the profile of the elderly who naps consists predominantly of women, married, retired, pre-frail, with an average age of 73 years, four years of study, with monthly family income of 3.9 minimum salary, with 4,4 children who were living with them only. The elderly reported napping on average 5.9 days per week, lasting 53.5 minutes per nap. Knowing the profile of the elderly who naps contributes to health professionals in the development of actions in relation to sleep problems of the frail/pre-frail elderly, preventing, minimizing or solving these problems. PMID:24626360

  17. Nap-Dependent Learning in Infants

    ERIC Educational Resources Information Center

    Hupbach, Almut; Gomez, Rebecca L.; Bootzin, Richard R.; Nadel, Lynn

    2009-01-01

    Sleep has been shown to aid a variety of learning and memory processes in adults (Stickgold, 2005 ). Recently, we showed that infants' learning also benefits from subsequent sleep such that infants who nap are able to abstract the general grammatical pattern of a briefly presented artificial language (Gomez, Bootzin & Nadel, 2006 ). In the present…

  18. NAPS: Network Analysis of Protein Structures.

    PubMed

    Chakrabarty, Broto; Parekh, Nita

    2016-07-01

    Traditionally, protein structures have been analysed by the secondary structure architecture and fold arrangement. An alternative approach that has shown promise is modelling proteins as a network of non-covalent interactions between amino acid residues. The network representation of proteins provide a systems approach to topological analysis of complex three-dimensional structures irrespective of secondary structure and fold type and provide insights into structure-function relationship. We have developed a web server for network based analysis of protein structures, NAPS, that facilitates quantitative and qualitative (visual) analysis of residue-residue interactions in: single chains, protein complex, modelled protein structures and trajectories (e.g. from molecular dynamics simulations). The user can specify atom type for network construction, distance range (in Å) and minimal amino acid separation along the sequence. NAPS provides users selection of node(s) and its neighbourhood based on centrality measures, physicochemical properties of amino acids or cluster of well-connected residues (k-cliques) for further analysis. Visual analysis of interacting domains and protein chains, and shortest path lengths between pair of residues are additional features that aid in functional analysis. NAPS support various analyses and visualization views for identifying functional residues, provide insight into mechanisms of protein folding, domain-domain and protein-protein interactions for understanding communication within and between proteins. URL:http://bioinf.iiit.ac.in/NAPS/. PMID:27151201

  19. National Academy of Sciences

    MedlinePlus

    ... Read More » Proceedings of the National Academy of Sciences (PNAS) PNAS is one of the world’s most- ... Exchange Evolution Resources Biographical Memoirs National Academy of Sciences About The NAS Mission History Organization Leadership and ...

  20. Sleep spindles in midday naps enhance learning in preschool children.

    PubMed

    Kurdziel, Laura; Duclos, Kasey; Spencer, Rebecca M C

    2013-10-22

    Despite the fact that midday naps are characteristic of early childhood, very little is understood about the structure and function of these sleep bouts. Given that sleep benefits memory in young adults, it is possible that naps serve a similar function for young children. However, children transition from biphasic to monophasic sleep patterns in early childhood, eliminating the nap from their daily sleep schedule. As such, naps may contain mostly light sleep stages and serve little function for learning and memory during this transitional age. Lacking scientific understanding of the function of naps in early childhood, policy makers may eliminate preschool classroom nap opportunities due to increasing curriculum demands. Here we show evidence that classroom naps support learning in preschool children by enhancing memories acquired earlier in the day compared with equivalent intervals spent awake. This nap benefit is greatest for children who nap habitually, regardless of age. Performance losses when nap-deprived are not recovered during subsequent overnight sleep. Physiological recordings of naps support a role of sleep spindles in memory performance. These results suggest that distributed sleep is critical in early learning; when short-term memory stores are limited, memory consolidation must take place frequently. PMID:24062429

  1. Sleep spindles in midday naps enhance learning in preschool children

    PubMed Central

    Kurdziel, Laura; Duclos, Kasey; Spencer, Rebecca M. C.

    2013-01-01

    Despite the fact that midday naps are characteristic of early childhood, very little is understood about the structure and function of these sleep bouts. Given that sleep benefits memory in young adults, it is possible that naps serve a similar function for young children. However, children transition from biphasic to monophasic sleep patterns in early childhood, eliminating the nap from their daily sleep schedule. As such, naps may contain mostly light sleep stages and serve little function for learning and memory during this transitional age. Lacking scientific understanding of the function of naps in early childhood, policy makers may eliminate preschool classroom nap opportunities due to increasing curriculum demands. Here we show evidence that classroom naps support learning in preschool children by enhancing memories acquired earlier in the day compared with equivalent intervals spent awake. This nap benefit is greatest for children who nap habitually, regardless of age. Performance losses when nap-deprived are not recovered during subsequent overnight sleep. Physiological recordings of naps support a role of sleep spindles in memory performance. These results suggest that distributed sleep is critical in early learning; when short-term memory stores are limited, memory consolidation must take place frequently. PMID:24062429

  2. Career Academy Course Sequences.

    ERIC Educational Resources Information Center

    Markham, Thom; Lenz, Robert

    This career academy course sequence guide is designed to give teachers a quick overview of the course sequences of well-known career academy and career pathway programs from across the country. The guide presents a variety of sample course sequences for the following academy themes: (1) arts and communication; (2) business and finance; (3)…

  3. Academies and School Diversity

    ERIC Educational Resources Information Center

    Curtis, Andrew

    2009-01-01

    This article considers the implications of Academies for the diversity of schooling in England. It seeks to establish the extent to which Academies are distinctive compared to other types of state secondary schools and whether this has been affected by a number of recent reforms. Different types of Academies are also be examined. Previous work in…

  4. Drill Presses.

    ERIC Educational Resources Information Center

    Engelbrecht, Nancy; And Others

    These instructional materials provide an orientation to the drill press for use at the postsecondary level. The first of seven sections lists seven types of drill presses. The second section identifies 14 drill press parts. The third section lists 21 rules for safe use of drilling machines. The fourth section identifies the six procedures for…

  5. Subjective and Objective Napping and Sleep in Older Adults: Are Evening Naps ‘Bad’ for Nighttime Sleep?

    PubMed Central

    Dautovich, Natalie D.; McCrae, Christina S.; Rowe, Meredeth

    2014-01-01

    Objectives To compare objective and subjective measurements of napping, and to examine the relationship between evening napping and nocturnal sleep in older adults. Design For twelve days, participants wore actigraphs and completed sleep diaries. Setting Community Participants 100 individuals who napped, 60–89 years (including good and poor sleepers with typical age-related medical comorbidities). Measurements Twelve days of sleep diary and actigraphy provided subjective and objective napping and sleep data. Results Evening naps (within 2 hours of bedtime) were characteristic of the sample with peak nap time occurring between 20:30–21:00 (average nap time occurred between 14:30–15:00). Two categories of nappers were identified: 1) day/evening – those who took both daytime and evening naps, and 2) daytime-only. Interestingly, no participants napped during the evening only. Day/evening nappers significantly underreported evening napping and demonstrated lower objectively measured sleep onset latencies (20 vs 26.5 minutes), less wake after sleep onset (51.4 vs 72.8 minutes), and higher sleep efficiencies (76.8 vs 82%) than daytime-only nappers. Conclusion Day/evening napping was prevalent amongst this sample of community-dwelling good/poor sleepers, but was not associated with impaired nocturnal sleep. Although the elimination or restriction of napping is a common element of cognitive-behavioral therapy for insomnia (CBTi), these results suggest that a uniform recommendation to restrict/eliminate napping (particularly evening napping) may not meet the needs of all older individuals with insomnia. PMID:18691289

  6. Association between Nighttime Sleep and Napping in Older Adults

    PubMed Central

    Goldman, Suzanne E.; Hall, Martica; Boudreau, Robert; Matthews, Karen A.; Cauley, Jane A.; Ancoli-Israel, Sonia; Stone, Katie L.; Rubin, Susan M.; Satterfield, Suzanne; Simonsick, Eleanor M.; Newman, Anne B.

    2008-01-01

    Study Objectives: Napping might indicate deficiencies in nighttime sleep, but the relationship is not well defined. We assessed the association of nighttime sleep duration and fragmentation with subsequent daytime sleep. Design: Cross-sectional study. Participants: 235 individuals (47.5% men, 29.7% black), age 80.1 (2.9) years. Measurements and Results: Nighttime and daytime sleep were measured with wrist actigraphy and sleep diaries for an average of 6.8 (SD 0.7) nights. Sleep parameters included total nighttime sleep (h), movement and fragmentation index (fragmentation), and total daytime sleep (h). The relationship of total nighttime sleep and fragmentation to napping (yes/no) was assessed using logistic regression. In individuals who napped, mixed random effects models were used to determine the association between the previous night sleep duration and fragmentation and nap duration, and nap duration and subsequent night sleep duration. All models were adjusted for age, race, gender, BMI, cognitive status, depression, cardiovascular disease, respiratory symptoms, diabetes, pain, fatigue, and sleep medication use. Naps were recorded in sleep diaries by 178 (75.7%) participants. The odds ratios (95% CI) for napping were higher for individuals with higher levels of nighttime fragmentation (2.1 [0.8, 5.7]), respiratory symptoms (2.4 [1.1, 5.4]), diabetes (6.1 [1.2, 30.7]), and pain (2.2 [1.0, 4.7]). Among nappers, neither sleep duration nor fragmentation the preceding night was associated with nap duration the next day. Conclusion: More sleep fragmentation was associated with higher odds of napping although not with nap duration. Further research is needed to determine the causal association between sleep fragmentation and daytime napping. Citation: Goldman SE; Hall M; Boudreau R; Matthews KA; Cauley JA; Ancoli-Israel S; Stone KL; Rubin SM; Satterfield S; Simonsick EM; Newman AB. Association between nighttime sleep and napping in older adults. SLEEP 2008

  7. American Academy of Audiology

    MedlinePlus

    ... ABA Certification Meetings & Events Employee Resources Research Practice Management Reimbursement Coding Compliance Resources and Tools Publications Audiology Today Journal of the American Academy of Audiology Books Brochures ...

  8. From the National Academies

    ERIC Educational Resources Information Center

    Labov, Jay B.

    2003-01-01

    In this issue, I provide information about an ongoing activity at the National Academies that will be of direct interest to biologists who are working to improve education in the life sciences. I also describe a recently published report and a forthcoming report on the Academies' efforts to help the nation develop a coherent strategy for improving…

  9. Talent Management in Academies

    ERIC Educational Resources Information Center

    Davies, Brent; Davies, Barbara J.

    2010-01-01

    Purpose: Academies are semi-autonomous schools set up outside the normal local government structures with sponsors from business and charity groups to create new and innovative ways of creating and sustaining school transformation. The aim of this paper is to assist in a strategic conversation within the academy movement on talent development.…

  10. Researching Academies in England

    ERIC Educational Resources Information Center

    Gunter, Helen; Woods, Philip; Woods, Glenys

    2008-01-01

    In 2002 the New Labour government launched the Academies programme (known initially as City Academies) with the target of 400, of which 200 are to opened by 2010. The espoused aim has been to tackle underachievement and encourage diversity of provision. However, it continues to be a controversial policy that is being driven by the Specialist…

  11. Napping facilitates word learning in early lexical development.

    PubMed

    Horváth, Klára; Myers, Kyle; Foster, Russell; Plunkett, Kim

    2015-10-01

    Little is known about the role that night-time sleep and daytime naps play in early cognitive development. Our aim was to investigate how napping affects word learning in 16-month-olds. Thirty-four typically developing infants were assigned randomly to nap and wake groups. After teaching two novel object-word pairs to infants, we tested their initial performance with an intermodal preferential looking task in which infants are expected to increase their target looking time compared to a distracter after hearing its auditory label. A second test session followed after approximately a 2-h delay. The delay contained sleep for the nap group or no sleep for the wake group. Looking behaviour was measured with an automatic eye-tracker. Vocabulary size was assessed using the Oxford Communicative Development Inventory. A significant interaction between group and session was found in preferential looking towards the target picture. The performance of the nap group increased after the nap, whereas that of the wake group did not change. The gain in performance correlated positively with the expressive vocabulary size in the nap group. These results indicate that daytime napping helps consolidate word learning in infancy. PMID:25950233

  12. Napping in College Students and Its Relationship with Nighttime Sleep

    ERIC Educational Resources Information Center

    Ye, Lichuan; Hutton Johnson, Stacy; Keane, Kathleen; Manasia, Michael; Gregas, Matt

    2015-01-01

    Objective: To examine the habit of napping and its relationship with nighttime sleep in college students. Participants: Four hundred and forty undergraduate students who responded to an anonymous online survey in April 2010. Methods: Three questions were asked to determine the frequency, length, and timing of napping during the past month. Sleep…

  13. Nap sleep spindle correlates of intelligence

    PubMed Central

    Ujma, Péter P.; Bódizs, Róbert; Gombos, Ferenc; Stintzing, Johannes; Konrad, Boris N.; Genzel, Lisa; Steiger, Axel; Dresler, Martin

    2015-01-01

    Sleep spindles are thalamocortical oscillations in non-rapid eye movement (NREM) sleep, that play an important role in sleep-related neuroplasticity and offline information processing. Several studies with full-night sleep recordings have reported a positive association between sleep spindles and fluid intelligence scores, however more recently it has been shown that only few sleep spindle measures correlate with intelligence in females, and none in males. Sleep spindle regulation underlies a circadian rhythm, however the association between spindles and intelligence has not been investigated in daytime nap sleep so far. In a sample of 86 healthy male human subjects, we investigated the correlation between fluid intelligence and sleep spindle parameters in an afternoon nap of 100 minutes. Mean sleep spindle length, amplitude and density were computed for each subject and for each derivation for both slow and fast spindles. A positive association was found between intelligence and slow spindle duration, but not any other sleep spindle parameter. As a positive correlation between intelligence and slow sleep spindle duration in full-night polysomnography has only been reported in females but not males, our results suggest that the association between intelligence and sleep spindles is more complex than previously assumed. PMID:26607963

  14. Determinants of cortisol awakening responses to naps and nighttime sleep.

    PubMed

    Devine, Jaime K; Wolf, Jutta M

    2016-01-01

    The cortisol awakening response (CAR) is a phenomenon describing the sharp increase in basal cortisol levels shortly after waking from sleep. While extensively studied, little is known about the role of sleep architecture contributing to CAR. Furthermore, the potential for CAR after a shorter bout of sleep--a nap--has not been directly investigated. The current studies thus aimed at assessed sleep duration, time of day, and sleep architecture as potential determinants of the cortisol awakening response. Saliva samples were collected during the first hour (0, 30, 45, 60 min) following several EEG-monitored laboratory sleep conditions. Those included afternoon naps wherein 17 participants (4 men; ages 18-26) napped for 50 min and 24 participants (11 men; ages 18-24) napped for 90 min. Furthermore, 20 participants (10 men; ages 18-35) visited the lab twice and in addition to staying overnight, napped 90 min in the morning either under placebo conditions or pharmacologically-manipulated sleep conditions (5mg Zolpidem). Cortisol increases were observed in response to each sleep condition except to 50-min afternoon naps. Furthermore, CARs were predicted by Stage 2 sleep when following nighttime sleep (r=.46, p=.04) and by Stage 1 sleep when following placebo morning naps (r=.54, p=.01). The current study established cortisol awakening responses to naps and implicates sleep duration and architecture in the generation of CAR to both napping and nighttime sleep. Assessing CAR in conjunction with the specific type of sleep may thus contribute to our understanding of mechanisms underlying positive and negative health effects of napping. PMID:26441231

  15. Physiological and evolutionary studies of NAP systems in Shewanella piezotolerans WP3

    PubMed Central

    Chen, Ying; Wang, Fengping; Xu, Jun; Mehmood, Muhammad Aamer; Xiao, Xiang

    2011-01-01

    Most of the Shewanella species contain two periplasmic nitrate reductases (NAP-α and NAP-β), which is a unique feature of this genus. In the present study, the physiological function and evolutionary relationship of the two NAP systems were studied in the deep-sea bacterium Shewanella piezotolerans WP3. Both of the WP3 nap gene clusters: nap-α (napD1A1B1C) and nap-β (napD2A2B2) were shown to be involved in nitrate respiration. Phylogenetic analyses suggest that NAP-β originated earlier than NAP-α. Tetraheme cytochromes NapC and CymA were found to be the major electron deliver proteins, and CymA also served as a sole electron transporter towards nitrite reductase. Interestingly, a ΔnapA2 mutant with the single functional NAP-α system showed better growth than the wild-type strain, when grown in nitrate medium, and it had a selective advantage to the wild-type strain. On the basis of these results, we proposed the evolution direction of nitrate respiration system in Shewanella: from a single NAP-β to NAP-β and NAP-α both, followed by the evolution to a single NAP-α. Moreover, the data presented here will be very useful for the designed engineering of Shewanella for more efficient respiring capabilities for environmental bioremediation. PMID:21124486

  16. American Academy of Ophthalmology

    MedlinePlus

    ... of millions of patients around the world. OPHTHALMOLOGY JOB CENTER Associate Vitreoretinal Surgeon & Medical Retina Physician | The ... physician hiring ophthalmologist / partnership opportunity | Confidential See all jobs Shop the Academy Store Focal Points 2016 Module: ...

  17. A 30-Minute, but Not a 10-Minute Nighttime Nap is Associated with Sleep Inertia

    PubMed Central

    Hilditch, Cassie J.; Centofanti, Stephanie A.; Dorrian, Jillian; Banks, Siobhan

    2016-01-01

    Study Objectives: To assess sleep inertia following 10-min and 30-min naps during a simulated night shift. Methods: Thirty-one healthy adults (aged 21–35 y; 18 females) participated in a 3-day laboratory study that included one baseline (BL) sleep (22:00–07:00) and one experimental night involving randomization to either: total sleep deprivation (NO-NAP), a 10-min nap (10-NAP) or a 30-min nap (30-NAP). Nap opportunities ended at 04:00. A 3-min psychomotor vigilance task (PVT-B), digit-symbol substitution task (DSST), fatigue scale, sleepiness scale, and self-rated performance scale were undertaken pre-nap (03:00) and at 2, 17, 32, and 47 min post-nap. Results: The 30-NAP (14.7 ± 5.7 min) had more slow wave sleep than the 10-NAP (0.8 ± 1.5 min; P < 0.001) condition. In the NO-NAP condition, PVT-B performance was worse than pre-nap (4.6 ± 0.3 1/sec) at 47 min post-nap (4.1 ± 0.4 1/sec; P < 0.001). There was no change across time in the 10-NAP condition. In the 30-NAP condition, performance immediately deteriorated from pre-nap (4.3 ± 0.3 1/sec) and was still worse at 47 min post-nap (4.0 ± 0.5 1/sec; P < 0.015). DSST performance deteriorated in the NO-NAP (worse than pre-nap from 17 to 47 min; P < 0.008), did not change in the 10-NAP, and was impaired 2 min post-nap in the 30-NAP condition (P = 0.028). All conditions self-rated performance as better than pre-nap for all post-nap test points (P < 0.001). Conclusions: This study is the first to show that a 10-min (but not a 30-min) nighttime nap had minimal sleep inertia and helped to mitigate short-term performance impairment during a simulated night shift. Self-rated performance did not reflect objective performance following a nap. Citation: Hilditch CJ, Centofanti SA, Dorrian J, Banks S. A 30-minute, but not a 10-minute nighttime nap is associated with sleep inertia. SLEEP 2016;39(3):675–685. PMID:26715234

  18. Electron transport to periplasmic nitrate reductase (NapA) of Wolinella succinogenes is independent of a NapC protein.

    PubMed

    Simon, Jörg; Sänger, Monica; Schuster, Stephan C; Gross, Roland

    2003-07-01

    The rumen bacterium Wolinella succinogenes grows by respiratory nitrate ammonification with formate as electron donor. Whereas the enzymology and coupling mechanism of nitrite respiration is well known, nitrate reduction to nitrite has not yet been examined. We report here that intact cells and cell fractions catalyse nitrate and chlorate reduction by reduced viologen dyes with high specific activities. A gene cluster encoding components of a putative periplasmic nitrate reductase system (napA, G, H, B, F, L, D) was sequenced. The napA gene was inactivated by inserting a kanamycin resistance gene cassette. The resulting mutant did not grow by nitrate respiration and did not reduce nitrate during growth by fumarate respiration, in contrast to the wild type. An antigen was detected in wild-type cells using an antiserum raised against the periplasmic nitrate reductase (NapA) from Paracoccus pantotrophus. This antigen was absent in the W. succinogenes napA mutant. It is concluded that the periplasmic nitrate reductase NapA is the only respiratory nitrate reductase in W. succinogenes, although a second nitrate-reducing enzyme is apparently induced in the napA mutant. The nap cluster of W. succinogenes lacks a napC gene whose product is thought to function in quinol oxidation and electron transfer to NapA in other bacteria. The W. succinogenes genome encodes two members of the NapC/NirT family, NrfH and FccC. Characterization of corresponding deletion mutants indicates that neither of these two proteins is required for nitrate respiration. A mutant lacking the genes encoding respiratory nitrite reductase (nrfHA) had wild-type properties with respect to nitrate respiration. A model of the electron transport chain of nitrate respiration is proposed in which one or more of the napF, G, H and L gene products mediate electron transport from menaquinol to the periplasmic NapAB complex. Inspection of the W. succinogenes genome sequence suggests that ammonia formation from

  19. Reduction of Nitrate in Shewanella oneidensis depends on atypical NAP and NRF systems with NapB as a preferred electron transport protein from CymA to NapA

    SciTech Connect

    Gao, Haichun; Yang, Zamin; Barua, Soumitra; Reed, Samantha B.; Romine, Margaret F.; Nealson, Kenneth H.; Fredrickson, Jim K.; Tiedje, James M.; Zhou, Jizhong

    2009-04-23

    In the genome of Shewanella oneidensis, a napDAGHB gene cluster encoding periplasmic nitrate reductase (NapA) and accessory proteins and an nrfA gene encoding periplasmic nitrite reductase (NrfA) have been identified. These two systems seem to be atypical because the genome lacks genes encoding cytoplasmic membrane electron transport proteins, NapC for NAP and NrfBCD/NrfH for NRF, respectively. Here, we present evidence that reduction of nitrate to ammonium in S. oneidensis is carried out by these atypical systems in a two-step manner. Transcriptional and mutational analyses suggest that CymA, a cytoplasmic membrane electron transport protein, is likely to be the functional replacement of both NapC and NrfH in S. oneidensis. Surprisingly, a strain devoid of napB encoding the small subunit of nitrate reductase exhibited the maximum cell density sooner than the wild type. Further characterization of this strain showed that nitrite was not detected as a free intermediate in its culture and NapB provides a fitness gain for S. oneidensis to compete for nitrate in the environments. On the basis results from mutational analyses of napA, napB, nrfA and napBnrfA in-frame deletion mutants, we propose that NapB is able to favor nitrate reduction by routing electrons to NapA exclusively.

  20. Daytime Sleepiness, Long Naps Linked to Heart Risks

    MedlinePlus

    ... release. "So, clarifying the relationship between naps and metabolic disease might offer a new strategy of treatment, especially as metabolic disease has been increasing steadily all over the world," ...

  1. Photocopy of original nap (from feeder book), New York State ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of original nap (from feeder book), New York State Archives and Manuscripts, Albany, New York), Holnes Hutchinson, surveyor, 1834 - Glens Falls Feeder, Sluice, Along south side of Glens Falls Feeder between locks 10 & 20, Hudson Falls, Washington County, NY

  2. Practice and nap schedules modulate children's motor learning.

    PubMed

    Ren, Jie; Guo, Wei; Yan, Jin H; Liu, Guanmin; Jia, Fujun

    2016-01-01

    Night- or day-time sleep enhances motor skill acquisition. However, prominent issues remained about the circadian (time-of-day) and homeostatic (time since last sleep) effects of sleep on developmental motor learning. Therefore, we examined the effects of nap schedules and nap-test-intervals (NTIs) on the learning of finger tapping sequences on computer keyboards. Children aged 6-7, 8-9, and 10-11 years explicitly acquired the short and long tapping orders that share the same movement strings (4-2-3-1-4, 4-2-3-1-4-2-3-1-4). Following a constant 8- or 10-hr post-learning period in one of the four NTIs (2, 4, 5, 7 hr), children in the morning napping groups, the afternoon napping groups, or the waking group performed the original long sequence in retention test (4-2-3-1-4-2-3-1-4) and the mirrored-order sequence in transfer test (1-3-2-4-1-3-2-4-1). Age and treatment differences in the movement time (MT, ms) and sequence accuracy (SA, %) were compared during skill learning and in retrieval tests. Results suggest that practice or nap affects MT and SA in a greater extent for the younger learners than for the older learners. The circadian effects might not change nap-based skill learning. Importantly, the longer NTIs resulted in superior retention performance than the shorter ones, suggesting that children require a relatively longer post-nap period to form motor memory. Finally, nap-based motor learning was more marked in skill retention than in skill transfer. Brain development may play an important role in motor learning. Our discussion centers on memory consolidation and its relevance for skill acquisition from early to late childhood. PMID:26582507

  3. NAP1 Strain Type Predicts Outcomes from Clostridium difficile Infection

    PubMed Central

    See, Isaac; Mu, Yi; Cohen, Jessica; Beldavs, Zintars G.; Winston, Lisa G.; Dumyati, Ghinwa; Holzbauer, Stacy; Dunn, John; Farley, Monica M.; Lyons, Carol; Johnston, Helen; Phipps, Erin; Perlmutter, Rebecca; Anderson, Lydia; Gerding, Dale N.; Lessa, Fernanda C.

    2015-01-01

    Background Studies conflict regarding the importance of the fluoroquinolone-resistant North American pulsed-field gel electrophoresis type 1 (NAP1) strain in Clostridium difficile infection (CDI) outcome. We describe strain types causing CDI and evaluate their association with patient outcomes. Methods CDI cases were identified from population-based surveillance. Multivariate regression models were used to evaluate the associations of strain type with severe disease (ileus, toxic megacolon, or pseudomembranous colitis within 5 days; or white blood cell count ≥15,000/mm3 within one day of positive test), severe outcome (intensive care unit admission after positive test, colectomy for C. difficile infection, or death within 30 days of positive test), and death within 14 days of positive test. Results Strain typing results were available for 2,057 cases. Severe disease occurred in 363 (17.7%) cases, severe outcome in 100 (4.9%), and death within 14 days in 56 (2.7%). The most common strain types were NAP1 (28.4%), NAP4 (10.2%) and NAP11 (9.1%). In unadjusted analysis, NAP1 was associated with greater odds of severe disease than other strains. After controlling for patient risk factors, healthcare exposure, and antibiotic use, NAP1 was associated with severe disease (adjusted odds ratio [aOR] 1.74, 95% confidence interval [CI], 1.36–2.22), severe outcome (aOR 1.66, 95% CI, 1.09–2.54), and death within 14 days (aOR 2.12, 95% CI, 1.22–3.68). Conclusion NAP1 was the most prevalent strain and a predictor of severe disease, severe outcome, and death. Strategies to reduce NAP1 prevalence, such as antibiotic stewardship to reduce fluoroquinolone use, might reduce CDI morbidity. PMID:24604900

  4. Napping and the selective consolidation of negative aspects of scenes.

    PubMed

    Payne, Jessica D; Kensinger, Elizabeth A; Wamsley, Erin J; Spreng, R Nathan; Alger, Sara E; Gibler, Kyle; Schacter, Daniel L; Stickgold, Robert

    2015-04-01

    After information is encoded into memory, it undergoes an offline period of consolidation that occurs optimally during sleep. The consolidation process not only solidifies memories, but also selectively preserves aspects of experience that are emotionally salient and relevant for future use. Here, we provide evidence that an afternoon nap is sufficient to trigger preferential memory for emotional information contained in complex scenes. Selective memory for negative emotional information was enhanced after a nap compared with wakefulness in 2 control conditions designed to carefully address interference and time-of-day confounds. Although prior evidence has connected negative emotional memory formation to REM sleep physiology, we found that non-REM delta activity and the amount of slow wave sleep (SWS) in the nap were robustly related to the selective consolidation of negative information. These findings suggest that the mechanisms underlying memory consolidation benefits associated with napping and nighttime sleep are not always the same. Finally, we provide preliminary evidence that the magnitude of the emotional memory benefit conferred by sleep is equivalent following a nap and a full night of sleep, suggesting that selective emotional remembering can be economically achieved by taking a nap. PMID:25706830

  5. Arabidopsis NAP1 Regulates the Formation of Autophagosomes.

    PubMed

    Wang, Pengwei; Richardson, Christine; Hawes, Chris; Hussey, Patrick J

    2016-08-01

    The SCAR/WAVE complex is required for ARP2/3-mediated actin nucleation, and these complexes are highly conserved in plants and animals [1, 2]. Proteins from the SCAR/WAVE complex have been found to be membrane associated in plants [3]. Using fluorescent protein fusions, we have found that NAP1 [4], a component of the SCAR/WAVE complex, locates to vesicles or puncta that appear upon applied pressure. These NAP1 vesicles can be endoplasmic reticulum (ER)-associated, can co-align with the cytoskeleton, and fuse to each other homotypically. More interestingly, the majority co-localizes with the autophagosome marker ATG8, and anti-NAP1 identifies autophagosomes in immuno-TEM. Macroautophagy (hereafter referred to as autophagy) is enhanced under certain stress conditions such as nitrogen starvation and salt stress. We show that fewer autophagosomes are generated in the NAP1 knockout mutant during starvation stress. The nap1 mutant (and KO mutants of other components of the SCAR/WAVE and ARP2/3 complexes) is more susceptible to nitrogen starvation and is less salt tolerant, indicating defective autophagy. In conclusion, our data show that NAP1 has another function in plant cells, and that is as a regulator of autophagy. PMID:27451899

  6. Academy Engages Incarcerated Youths

    ERIC Educational Resources Information Center

    Zehr, Mary Ann

    2010-01-01

    It's not easy to keep young people on task for learning in a youth prison, but David Domenici, the principal of the Maya Angelou Academy, a charter-like school serving incarcerated juveniles, is trying to do it while at the same time creating a model program for improving educational services for young offenders. Located at the New Beginnings…

  7. Valor Collegiate Academies

    ERIC Educational Resources Information Center

    EDUCAUSE, 2015

    2015-01-01

    The four guiding principles behind the blended, competency-based, personalized learning model of Valor Collegiate Academies, a charter organization serving grades 5-12 in Nashville, TN: (1) Reflect the diversity of both our country and local community; (2) Personalize a student's experience to meet his/her unique academic and non-academic needs;…

  8. Legends of the Academy

    ERIC Educational Resources Information Center

    Hernandez, Arelis

    2009-01-01

    For this special edition on "Higher Education Careers," "Diverse" caught up with some legends whose careers have made an indelible impact on the academy. "Diverse" found that even in retirement, or semi-retirement, these pioneers never venture far from the passions that made them great educators and diversity advocates. This article features four…

  9. Benjamin Franklin Street Academy.

    ERIC Educational Resources Information Center

    Wohl, Seth F.

    In this evaluation report of the sixth year of operation of the Benjamin Franklin-Urban League Street Academy in New York City, it is recommended that the program be continued for the seventh year despite the poorer than expected student gains in all studied components and the sporadic student attendance pattern and high dropout rate. Students…

  10. Dual Enrollment Academy Programs

    ERIC Educational Resources Information Center

    Gonzalez, Nicolas; Chavez, Guadalupe

    2009-01-01

    Dual Enrollment Engineering (DEEA) and Medical Science (DEMSA) Academies are two-year dual enrollment programs for high school students. Students explore engineering and medical careers through college coursework. Students prepare for higher education in engineering and medical fields while completing associate degrees in biology or engineering…

  11. Peninsula Academies Program.

    ERIC Educational Resources Information Center

    Sequoia Union High School District, Redwood City, CA.

    THE FOLLOWING IS THE FULL TEXT OF THIS DOCUMENT: The Peninsula Academies program helps educationally disadvantaged youth overcome the handicaps of low academic achievement, lack of skills, and chronic unemployment. This is accomplished by providing a high school curriculum that is clearly related to work, training in specific job skills, emphasis…

  12. Free Schools and Academies

    ERIC Educational Resources Information Center

    Eades, Jane

    2014-01-01

    The number and range of problems associated with academies and "free" schools is worrying and can be attributed to the lack of ability of central Government to oversee the increasingly fragmented education provision. In this article, the author looks at just a few of those problems which have been reported since she started to log them…

  13. The California Partnership Academies.

    ERIC Educational Resources Information Center

    Raby, Marilyn

    The California Partnership Academies Program is a highly successful school/business collaboration that allows students who are at risk of not graduating from high school to see clearly the connection between school and the workplace. The following key components are discussed: (1) an at-risk student population made up largely of the educationally…

  14. Education at the National Academies

    ERIC Educational Resources Information Center

    Labov, Jay B.

    2003-01-01

    This article highlights several programs at the National Academies that should be useful to educators in biology. These include works under the aegis of the National Academy of Sciences' Office on Public Understanding of Science, the National Academy of Engineering's (NAE's) ongoing work on improving technological literacy, and joint work by the…

  15. Calar Alto Academy

    NASA Astrophysics Data System (ADS)

    Pedraz, Santos; Galadí, David

    Calar Alto Academy was initiated in 2007 with the aim to give students from different Spanish universities the chance to perform professional observational work at Calar Alto Observatory. The second edition of this innovative educational project has increased the number of participating universities and has almost doubled the quantity of visiting students, in a significant step towards the consolidation of this undergraduate and graduate school of observational astronomy.

  16. Use of NAP gene to manipulate leaf senescence in plants

    DOEpatents

    Gan, Susheng; Guo, Yongfeng

    2013-04-16

    The present invention discloses transgenic plants having an altered level of NAP protein compared to that of a non-transgenic plant, where the transgenic plants display an altered leaf senescence phenotype relative to a non-transgenic plant, as well as mutant plants comprising an inactivated NAP gene, where mutant plants display a delayed leaf senescence phenotype compared to that of a non-mutant plant. The present invention also discloses methods for delaying leaf senescence in a plant, as well as methods of making a mutant plant having a decreased level of NAP protein compared to that of a non-mutant plant, where the mutant plant displays a delayed leaf senescence phenotype relative to a non-mutant plant. Methods for causing precocious leaf senescence or promoting leaf senescence in a plant are also disclosed. Also disclosed are methods of identifying a candidate plant suitable for breeding that displays a delayed leaf senescence and/or enhanced yield phenotype.

  17. Napping Promotes Inter-Session Habituation to Emotional Stimuli

    PubMed Central

    Pace-Schott, Edward F.; Shepherd, Elizabeth; Spencer, Rebecca M.C.; Marcello, Matthew; Tucker, Matthew; Propper, Ruth E.; Stickgold, Robert

    2010-01-01

    The effects of a daytime nap on inter-session habituation to aversive visual stimuli were investigated. Healthy young adult volunteers viewed repeated presentations of highly negative and emotionally neutral (but equally arousing) International Affective Picture System (IAPS) photographs during two afternoon sessions separated by 2.5 hrs. Half of the photographs were shown at both sessions (Repeated Sets) and half differed between sessions (Novel Sets). For each stimulus presentation, evoked skin conductance response (SCR), heart rate deceleration (HRD) and corrugator supercilii EMG response (EMG), were computed and range corrected using respective maximum session-1 responses. Following each presentation, subjects rated each photograph on dimensions of pleasantness and arousability. During the inter-session interval, Nap subjects had a 120-min polysomnographically monitored sleep opportunity, whereas Wake subjects watched a non-stimulating video. Nap and Wake subjects did not differ in their subjective ratings of photographs. However, for Repeated-Set photographs, Nap subjects demonstrated greater inter-session habituation in SCR and EMG but a trend toward lesser inter-session habituation in HRD. These group differences were absent for Novel-Set photographs. Group differences across all measures were greater for negative stimuli. Occurrence of SWS during the nap was associated with greater inter-session habituation of EMG whereas occurrence of REM was associated with lesser inter-session habituation of SCR to negative stimuli. Sleep may therefore promote emotional adjustment at the level of somatic responses. Physiological but not subjective inter-session habituation to aversive images was enhanced by a daytime nap. PMID:20969968

  18. Press Start

    NASA Astrophysics Data System (ADS)

    Harteveld, Casper

    This level sets the stage for the design philosophy called “Triadic Game Design” (TGD). This design philosophy can be summarized with the following sentence: it takes two to tango, but it takes three to design a meaningful game or a game with a purpose. Before the philosophy is further explained, this level will first delve into what is meant by a meaningful game or a game with a purpose. Many terms and definitions have seen the light and in this book I will specifically orient at digital games that aim to have an effect beyond the context of the game itself. Subsequently, a historical overview is given of the usage of games with a serious purpose which starts from the moment we human beings started to walk on our feet till our contemporary society. It turns out that we have been using games for all kinds of non-entertainment purposes for already quite a long time. With this introductory material in the back of our minds, I will explain the concept of TGD by means of a puzzle. After that, the protagonist of this book, the game Levee Patroller, is introduced. Based on the development of this game, the idea of TGD, which stresses to balance three different worlds, the worlds of Reality, Meaning, and Play, came into being. Interested? Then I suggest to quickly “press start!”

  19. Electrocatalytic reduction of nitrate and selenate by NapAB.

    PubMed

    Gates, Andrew J; Butler, Clive S; Richardson, David J; Butt, Julea N

    2011-01-01

    Bacterial cellular metabolism is renowned for its metabolic diversity and adaptability. However, certain environments present particular challenges. Aerobic metabolism of highly reduced carbon substrates by soil bacteria such as Paracoccus pantotrophus presents one such challenge since it may result in excessive electron delivery to the respiratory redox chain when compared with the availability of terminal oxidant, O2. The level of a periplasmic ubiquinol-dependent nitrate reductase, NAP, is up-regulated in the presence of highly reduced carbon substrates. NAP oxidizes ubiquinol at the periplasmic face of the cytoplasmic membrane and reduces nitrate in the periplasm. Thus its activity counteracts the accumulation of excess reducing equivalents in ubiquinol, thereby maintaining the redox poise of the ubiquinone/ubiquinol pool without contributing to the protonmotive force across the cytoplasmic membrane. Although P. pantotrophus NapAB shows a high level of substrate specificity towards nitrate, the enzyme has also been reported to reduce selenate in spectrophotometric solution assays. This transaction draws on our current knowledge concerning the bacterial respiratory nitrate reductases and extends the application of PFE (protein film electrochemistry) to resolve and quantify the selenate reductase activity of NapAB. PMID:21265780

  20. Nap Schedules and Sleep Practices in Infant-Toddler Groups.

    ERIC Educational Resources Information Center

    Siren-Tiusanen, Helena; Robinson, Helja Antola

    2001-01-01

    Analyzed sleep-wake schedules and nap times in multiage infant-toddler groups through three case studies in Finnish day care centers. Found complex interactions among family daily patterns, day care patterns, and young children's sleep disturbances. Identified major differences in day care practices regarding sleep quality related to timing,…

  1. Types of Primary Insomnia: Is Hyperarousal Also Present during Napping?

    PubMed Central

    Pérusse, Alexandra D.; Turcotte, Isabelle; St-Jean, Geneviève; Ellis, Jason; Hudon, Carol; Bastien, Célyne H.

    2013-01-01

    Study Objectives: The objective of this study was to identify if hyperarousal is a 24-hour phenomenon in insomnia by comparing sleep during napping between good sleepers (GS) and Insomnia sufferers (INS) (subdivided into paradoxical “PARA-I” and psychophysiological “PSY-I”) following a mentally challenging battery of cognitive tests. Design: Cross-sectional comparisons of GS, PSY-I, and PARA-I. Setting: Participants slept for 4 consecutive nights in the laboratory where PSG was recorded. Upon awakening on mornings 2 and 3, cognitive testing (lasting 90-120 min) was administered, followed by a 20-minute nap. Participants: Fourteen PSY-I, 12 PARA-I, and 23 GS completed the study, comprising home questionnaires, clinical interviews, night PSG recordings, cognitive testing, and nap PSG recordings. All participants were between 25 and 50 years of age and met inclusion criteria for PSY-I, PARA-I, or GS. Interventions: N/A. Measurements and Results: On objective nap parameters, GS had a longer total sleep time (TST; p = 0.008) and better sleep efficiency (SE; p = 0.009), than PSY-I and PARA-I, and both groups of INS were awake significantly longer than GS (p = 0.003). Also, PARA-I took significantly more time than GS to fall asleep (p = 0.014). Subjectively reported sleepiness was comparable across the three groups. Positive relationships were observed between SE over the night and SE over the nap the following day. Conclusions: Results show that GS sleep better than INS during naps following prolonged cognitive testing, suggesting that, in INS, hyperarousal predominates over mental fatigue resulting from these tests. These results may parallel what is observed at night when INS experience increased cognitive load but are unable to fall asleep. Citation: Pérusse AD; Turcotte I; St-Jean G; Ellis J; Hudon C; Bastien CH. Types of primary insomnia: is hyperarousal also present during napping? J Clin Sleep Med 2013;9(12):1273-1280. PMID:24340289

  2. Day-to-day Variability in Nap Duration Predicts Medical Morbidity in Older Adults

    PubMed Central

    Dautovich, Natalie D.; Kay, Daniel B.; Perlis, Michael L.; Dzierzewski, Joseph M.; Rowe, Meredeth A.; McCrae, Christina S.

    2014-01-01

    Objective The objectives for the present study were to: 1) examine within-person variability of nap duration and 2) assess how variability in nap duration is related to the number of health conditions in a sample of older adults. For highly variable behaviors such as sleep, it is important to consider fluctuations within the person instead of solely comparing averages of behaviors across persons. Methods Data were drawn from a previous study examining sleep in 103 community-dwelling older adults. Subjective estimates of napping behavior were obtained from sleep diaries and objective estimates of napping behavior were obtained using actigraphy. Both measures were collected for 14 consecutive days. The sampled data were aggregated in terms of: 1) average daily time spent napping and 2) average within-person fluctuations in daily nap duration. The health measure consisted of the number of self-reported health conditions. Results Both the objective and subjective measures revealed that there was considerable day-to-day fluctuation in nap duration and that variability in nap duration, not mean duration, uniquely predicted the number of health conditions, [b=.03, b*=.26, t(100)= 2.71, p = .01]. Conclusions Duration of napping in the elderly is a highly variable behavior, fluctuating as much within- as between-person. Further, variability in nap duration from day-to-day is predictive of greater medical morbidity, suggesting that clinicians should assess for inconsistencies in nap behavior in addition to duration, frequency, and timing. PMID:22369491

  3. Resolution of two native monomeric 90 kDa nitrate reductase active proteins from Shewanella gelidimarina and the sequence of two napA genes

    SciTech Connect

    Simpson, Philippa J.L.; McKinzie, Audra A.; Codd, Rachel; School of Medical Sciences and Bosch Institute, University of Sydney, NSW 2006

    2010-07-16

    Research highlights: {yields} Two monomeric 90 kDa nitrate reductase active proteins from Shewanella gelidimarina. {yields} Sequence of napA from napEDABC-type operon and napA from NapDAGHB-type operon. {yields} Isolation of NAP as NapA or NapAB correlated with NapA P47E amino acid substitution. -- Abstract: The reduction of nitrate to nitrite in the bacterial periplasm occurs in the 90 kDa NapA subunit of the periplasmic nitrate reductase (NAP) system. Most Shewanella genomes contain two nap operons: napEDABC and napDAGHB, which is an unusual feature of this genus. Two native, monomeric, 90 kDa nitrate reductase active proteins were resolved by hydrophobic interaction chromatography from aerobic cultures of Shewanella gelidimarina replete with reduced nitrogen compounds. The 90 kDa protein obtained in higher yield was characterized as NapA by electronic absorption and electron paramagnetic resonance spectroscopies and was identified by LC/MS/MS and MALDI-TOF/TOF MS as NapA from the napEDABC-type operon. The other 90 kDa protein, which was unstable and produced in low yields, was posited as NapA from the napDAGHB-type operon. Two napA genes have been sequenced from the napEDABC-type and napDAGHB-type operons of S. gelidimarina. Native NAP from S. putrefaciens was resolved as one NapA monomer and one NapAB heterodimer. Two amino acid substitutions in NapA correlated with the isolation of NAP as a NapA monomer or a NapAB heterodimer. The resolution of native, redox-active NapA isoforms in Shewanella provides new insight into the respiratory versatility of this genus, which has implications in bioremediation and the assembly of microbial fuel cells.

  4. Strasbourg's "Academy" observatory

    NASA Astrophysics Data System (ADS)

    Heck, André

    2011-08-01

    The observing post located on the roof of Strasbourg's 19th-century "Academy" is generally considered as the second astronomical observatory of the city: a transitional facility between the (unproductive) turret lantern at the top of the Hospital Gate and the German (Wilhelminian) Observatory. The current paper reviews recent findings from archives (blueprints, inventories, correspondence, decrees and other documents) shedding some light on this observatory of which virtually nothing was known to this day. While being, thanks to Chrétien Kramp (1760-1826), an effective attempt to establish an actual observatory equipped with genuine instrumentation, the succession of political regimes in France and the continual bidding for moving the university to other locations, together with the faltering of later scholars, torpedoed any significant scientific usage of the place. A meridian instrument with a Cauchoix objective doublet was however recovered by the German observatory and is still existing.

  5. Planning Guide for Career Academies

    ERIC Educational Resources Information Center

    Dayton, Charles

    2010-01-01

    A career academy is a small learning community within a high school, which selects a subset of students and teachers for a two-, three-, or four-year period. Students enter through a voluntary process; they must apply and be accepted, with parental knowledge and support. A career academy involves teachers from different subjects working together…

  6. Education at the National Academies

    ERIC Educational Resources Information Center

    Labov, Jay B.

    2003-01-01

    The past three issues of "Cell Biology Education" (CBE) have provided overviews of education projects within the National Research Council's (NRC's) Center for Education, Board on Life Sciences, National Academy of Engineering, and National Academy of Science's Office of Public Understanding of Science. In this article, the author provides…

  7. American Academy of Home Care Medicine

    MedlinePlus

    ... Newsletter Certification/Training Donate Featured Members Home Care Medicine in America The American Academy of Home Care ... Resources with the American Academy of Home Care Medicine. The American Academy of Home Care Medicine understands ...

  8. The utility of a 5th nap in multiple sleep latency test

    PubMed Central

    Lykouras, Dimosthenis; Rees, Kate

    2016-01-01

    Background This is the first study that aimed to look specifically at the utility of the 5th nap in the multiple sleep latency test (MSLT), a test used to assist in the diagnosis of narcolepsy. Methods Data was retrospectively collected from the Sleep Disorders Centre of a Tertiary Hospital on patients that had a 5th nap during their MSLT from the 08th November 2011 to 12th November 2014. Results Fifty-three patients had a 5th nap performed out of 378 MSLT studies. In 16% of cases a diagnosis of narcolepsy was given directly due to the inclusion of the 5th nap on the MSLT. Here a 5th nap allowed diagnostic criteria of mean sleep latency <8 minutes and >2 SOREMPS to be met. In 53% of cases the mean sleep latency increased due to 5th nap inclusion; the mean sleep latency of the first four naps was 5.6 vs. 6.7 after inclusion of the 5th nap. Conclusions The 5th nap is not often performed within the MSLT studies. Our study shows that only a few patients may benefit from a 5th nap opportunity which also led to increase of the mean sleep latency at the expense of extra time, cost, labour and increased patient anxiety. PMID:26904269

  9. Intranasal Delivery of Recombinant NT4-NAP/AAV Exerts Potential Antidepressant Effect.

    PubMed

    Ma, Xian-Cang; Chu, Zheng; Zhang, Xiao-Ling; Jiang, Wen-Hui; Jia, Min; Dang, Yong-Hui; Gao, Cheng-Ge

    2016-06-01

    The present study was designed to construct a recombinant adeno-associated virus (rAAV) which can express NAP in the brain and examine whether this virus can produce antidepressant effects on C57 BL/6 mice that had been subjected to open field test and forced swimming test, via nose-to-brain pathway. When the recombinant plasmid pGEM-T Easy/NT4-NAP was digested by EcoRI, 297 bp fragments can be obtained and NT4-NAP sequence was consistent with the designed sequence confirmed by DNA sequencing. When the recombinant plasmid pSSCMV/NT4-NAP was digested by EcoRI, 297 bp fragments is visible. Immunohistochemical staining of fibroblasts revealed that expression of NAP was detected in NT4-NAP/AAV group. Intranasal delivery of NT4-NAP/AAV significantly reduced immobility time when the FST was performed after 1 day from the last administration. The effects observed in the FST could not be attributed to non-specific increases in activity since intranasal delivery of NT4-NAP/AAV did not alter the behavior of the mice during the open field test. The results indicated that a recombinant AAV vector which could express NAP in cells was successfully constructed and NAP may be a potential target for therapeutic action of antidepressant treatment. PMID:26846142

  10. Sonochemical synthesis of zeolite NaP from clinoptilolite.

    PubMed

    Behin, Jamshid; Kazemian, Hossein; Rohani, Sohrab

    2016-01-01

    In the present work, natural clinoptilolite was converted to zeolite NaP using ultrasonic energy, in which the transformation time shortened remarkably. The effect of post-synthesis treatment using conventional hydrothermal was also investigated. The synthesized powders were characterized by XRD, TGA/DTA, SEM, and PSD analysis. The results showed that, increasing the sonication time (energy) has no significant effect on the product's morphology. The crystallinity of the synthesized samples increased slightly with increasing sonication time, but their yield remained relatively unchanged. Furthermore, post-synthesis hydrothermal treatment showed very little influence on properties of the final product. Because the ultrasonic irradiation creates acoustic cavitation cracks on the surface structure of clinoptilolite particulates and increases the concentration of soluble alumino-silicate species, which favors the prevailing super-saturation, crystallization and crystal growth of zeolite NaP happen faster. The particles of zeolite NaP synthesized by ultrasonic irradiation consist of small crystallites of uniform size. PMID:26341462

  11. Post-sleep inertia performance benefits of longer naps in simulated nightwork and extended operations.

    PubMed

    Mulrine, Hannah M; Signal, T Leigh; van den Berg, Margo J; Gander, Philippa H

    2012-11-01

    Operational settings involving shiftwork or extended operations require periods of prolonged wakefulness, which in conjunction with sleep loss and circadian factors, can have a negative impact on performance, alertness, and workplace safety. Napping has been shown to improve performance and alertness after periods of prolonged wakefulness and sleep loss. Longer naps may not only result in longer-lasting benefits but also increase the risk of sleep inertia immediately upon waking. The time course of performance after naps of differing durations is thus an important consideration in weighing the benefits and risks of napping in workplace settings. The objective of this study was to evaluate the effectiveness of nap opportunities of 20, 40, or 60 min for maintaining alertness and performance 1.5-6 h post-nap in simulated nightwork (P1) or extended operations (P2). Each protocol included 12 participants in a within-subjects design in a controlled laboratory environment. After a baseline 8 h time-in-bed, healthy young males (P1 mean age 25.1 yr; P2 mean age 23.2 yr) underwent either ≈ 20 h (P1) or ≈ 30 h (P2) of sleep deprivation on four separate occasions, followed by nap opportunities of 0, 20, 40, and 60 min. Sleep on the baseline night and during the naps was recorded polysomnographically. During the nap opportunities, sleep onset latency was short and sleep efficiency was high. A greater proportion of slow-wave sleep (SWS) was obtained in nap opportunities of 40 and 60 min compared with 20 min. Rapid eye movement (REM) sleep occurred infrequently. A subjective sleepiness rating (Karolinska Sleepiness Scale, KSS), 2-Back Working Memory Task (WMT), and Psychomotor Vigilance Task (PVT) were completed 1.5, 2, 2.5, 3, 4, 5, and 6 h post-nap. The slowest 10% of PVT responses were significantly faster after 40 and 60 min naps compared with a 20 min (P1) or no (P2) nap. There were significantly fewer PVT lapses after 40 and 60 min naps compared with no nap (P2), and

  12. The histone chaperones Vps75 and Nap1 form ring-like, tetrameric structures in solution

    PubMed Central

    Bowman, Andrew; Hammond, Colin M.; Stirling, Andrew; Ward, Richard; Shang, Weifeng; El-Mkami, Hassane; Robinson, David A.; Svergun, Dmitri I.; Norman, David G.; Owen-Hughes, Tom

    2014-01-01

    NAP-1 fold histone chaperones play an important role in escorting histones to and from sites of nucleosome assembly and disassembly. The two NAP-1 fold histone chaperones in budding yeast, Vps75 and Nap1, have previously been crystalized in a characteristic homodimeric conformation. In this study, a combination of small angle X-ray scattering, multi angle light scattering and pulsed electron–electron double resonance approaches were used to show that both Vps75 and Nap1 adopt ring-shaped tetrameric conformations in solution. This suggests that the formation of homotetramers is a common feature of NAP-1 fold histone chaperones. The tetramerisation of NAP-1 fold histone chaperones may act to shield acidic surfaces in the absence of histone cargo thus providing a ‘self-chaperoning’ type mechanism. PMID:24688059

  13. American Academy of Forensic Sciences

    MedlinePlus

    ... Scientific Meeting — New Orleans, Louisiana 2017 Discover More Forensic Science Education Programs Accreditation Commission (FEPAC) Read More So You Want to Be a Forensic Scientist! Read More ‹ › The American Academy of Forensic ...

  14. Utah Principals Academy, 1987-1988.

    ERIC Educational Resources Information Center

    Utah State Board of Education, Salt Lake City.

    Improving instructional leadership skills of principals is the focus of the academy. Following a foreword and mission statement by James R. Moss, the state superintendent of public instruction, the booklet describes three programs that help to achieve the academy's goals: Academy Fellows, Academy Seminars, and Cluster Grants. Titles and authors of…

  15. DIRECTORY AND PROCEEDINGS, ACADEMY-CONFERENCE - 1966.

    ERIC Educational Resources Information Center

    American Association for the Advancement of Science, Washington, DC.

    THIS DOCUMENT IS A REPORT OF THE 1966 AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE (AAAS) ACADEMY AND JUNIOR ACADEMY CONFERENCE AND A DIRECTORY TO OVER 40 STATE, REGIONAL, AND CITY ACADEMIES. REPORTED WERE (1) THE OFFICERS FOR 1966 AND 1967, (2) THE AAAS ACADEMY CONFERENCE COMMITTEES FOR 1966, (3) THE PRESIDENTIAL ADDRESS ON "THE REQUISITES…

  16. The Peninsula Academies. Third Yearly Interim Report.

    ERIC Educational Resources Information Center

    Reynolds, Dorothy F.

    The performance of the Peninsula Academies of Electronics and Computer Technology was assessed for the program's third year of operation in two host schools in the Sequoia Union High School District. Data were collected for approximately 190 Academy students and for a comparison group of non-Academy students. Academies students missed fewer days…

  17. 32 CFR 575.1 - Military Academy.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 3 2013-07-01 2013-07-01 false Military Academy. 575.1 Section 575.1 National... MILITARY ACADEMY § 575.1 Military Academy. (a) Organization and administration. (1) The United States Military Academy is under the general direction and supervision of the Department of the Army....

  18. 32 CFR 575.1 - Military Academy.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 3 2011-07-01 2009-07-01 true Military Academy. 575.1 Section 575.1 National... MILITARY ACADEMY § 575.1 Military Academy. (a) Organization and administration. (1) The United States Military Academy is under the general direction and supervision of the Department of the Army....

  19. Does Increased Consolidated Nighttime Sleep Facilitate Attentional Control? A Pilot Study of Nap Restriction in Preschoolers

    PubMed Central

    Lam, Janet C.; Koriakin, Taylor A.; Scharf, Steven M.; Mason, Thornton B. A.; Mahone, E. Mark

    2016-01-01

    Objective The aim of this study is to understand the impact of a 5-day period of nap restriction on sleep patterns and cognitive function in typically developing preschoolers, aged 3 to 4 years. Method Following 1 week of baseline assessment, 28 children were randomly assigned to either a “napping as usual” group (n = 15) or a 5-day period of nap restriction (n = 13). Sleep was assessed with sleep logs and actigraphy; cognition was assessed at baseline and at the end of the intervention week. Results No group differences in sleep or cognitive function were observed at baseline. For the no-nap group, the 5-day period of daytime nap restriction resulted in increased nighttime sleep. Children in the no-nap group also showed a significant improvement in attentional control compared with baseline, whereas no such changes were observed among children in the napping-as-usual group. Conclusion In preschool children who typically take naps, short-term nap restriction is associated with increased nighttime sleep and may contribute to improved attentional function. PMID:25646024

  20. Education at the National Academies: Three Recent Reports on Improving Science Education

    ERIC Educational Resources Information Center

    Labov, Jay B.

    2006-01-01

    In this article, the author describes three reports conducted by the National Academies, a private, nonprofit organization whose charter is to assist the federal government and the American people in analyzing pressing science and technology policy issues. These reports are: (1) "Rising Above the Gathering Storm: Energizing and Employing America…

  1. Reciprocating pellet press

    DOEpatents

    Jones, Charles W.

    1981-04-07

    A machine for pressing loose powder into pellets using a series of reciprocating motions has an interchangeable punch and die as its only accurately machines parts. The machine reciprocates horizontally between powder receiving and pressing positions. It reciprocates vertically to press, strip and release a pellet.

  2. The Global University Press

    ERIC Educational Resources Information Center

    Dougherty, Peter J.

    2012-01-01

    The modern world's understanding of American university press has long been shaped by university-press books. American university-press books are good international advertisements for the universities whose logos grace their spines. The growth of transnational scholarship and the expansion of digital communications networks are converging in ways…

  3. Periplasmic Nitrate Reductase (NapABC Enzyme) Supports Anaerobic Respiration by Escherichia coli K-12

    PubMed Central

    Stewart, Valley; Lu, Yiran; Darwin, Andrew J.

    2002-01-01

    Periplasmic nitrate reductase (NapABC enzyme) has been characterized from a variety of proteobacteria, especially Paracoccus pantotrophus. Whole-genome sequencing of Escherichia coli revealed the structural genes napFDAGHBC, which encode NapABC enzyme and associated electron transfer components. E. coli also expresses two membrane-bound proton-translocating nitrate reductases, encoded by the narGHJI and narZYWV operons. We measured reduced viologen-dependent nitrate reductase activity in a series of strains with combinations of nar and nap null alleles. The napF operon-encoded nitrate reductase activity was not sensitive to azide, as shown previously for the P. pantotrophus NapA enzyme. A strain carrying null alleles of narG and narZ grew exponentially on glycerol with nitrate as the respiratory oxidant (anaerobic respiration), whereas a strain also carrying a null allele of napA did not. By contrast, the presence of napA+ had no influence on the more rapid growth of narG+ strains. These results indicate that periplasmic nitrate reductase, like fumarate reductase, can function in anaerobic respiration but does not constitute a site for generating proton motive force. The time course of Φ(napF-lacZ) expression during growth in batch culture displayed a complex pattern in response to the dynamic nitrate/nitrite ratio. Our results are consistent with the observation that Φ(napF-lacZ) is expressed preferentially at relatively low nitrate concentrations in continuous cultures (H. Wang, C.-P. Tseng, and R. P. Gunsalus, J. Bacteriol. 181:5303-5308, 1999). This finding and other considerations support the hypothesis that NapABC enzyme may function in E. coli when low nitrate concentrations limit the bioenergetic efficiency of nitrate respiration via NarGHI enzyme. PMID:11844760

  4. 1997 NASA Academy in Aeronautics

    NASA Technical Reports Server (NTRS)

    Andrisani, Dominick, II

    1998-01-01

    The NASA Academy in Aeronautics at the Dryden Flight Research Center (DFRC) was a ten-week summer leadership training program conducted for the first time in the summer of 1997. Funding was provided by a contract between DFRC and Purdue University. Mr. Lee Duke of DFRC was the contract monitor, and Professor Dominick Andrisani was the principal investigator. Five student research associates participated in the program. Biographies of the research associates are given in Appendix 1. Dominick Andrisani served as Dean of the NASA Academy in Aeronautics. NASA Academy in Aeronautics is a unique summer institute of higher learning that endeavors to provide insight into all of the elements that make NASA aeronautical research possible. At the same time the Academy assigns the research associate to be mentored by one of NASA!s best researchers so that they can contribute towards an active flight research program. Aeronautical research and development are an investment in the future, and NASA Academy is an investment in aeronautical leaders of the future. The Academy was run by the Indiana Space Grant Consortium at Purdue in strategic partnership with the National Space Grant College and Fellowship Program. Research associates at the Academy were selected with help from the Space Grant Consortium that sponsored the research associate. Research associate stipend and travel to DFRC were paid by the students' Space Grant Consortium. All other student expenses were paid by the Academy. Since the Academy at DFRC had only five students the opportunity for individual growth and attention was unique in the country. About 30% of the working time and most of the social time of the students were be spent as a "group" or "team." This time was devoted to exchange of ideas, on forays into the highest levels of decision making, and in executing aeronautical research. This was done by interviewing leaders throughout the aerospace industry, seminars, working dinners, and informal

  5. Multisite phosphorylation of C-Nap1 releases it from Cep135 to trigger centrosome disjunction

    PubMed Central

    Hardy, Tara; Lee, Miseon; Hames, Rebecca S.; Prosser, Suzanna L.; Cheary, Donna-Marie; Samant, Mugdha D.; Schultz, Francisca; Baxter, Joanne E.; Rhee, Kunsoo; Fry, Andrew M.

    2014-01-01

    ABSTRACT During mitotic entry, centrosomes separate to establish the bipolar spindle. Delays in centrosome separation can perturb chromosome segregation and promote genetic instability. However, interphase centrosomes are physically tethered by a proteinaceous linker composed of C-Nap1 (also known as CEP250) and the filamentous protein rootletin. Linker disassembly occurs at the onset of mitosis in a process known as centrosome disjunction and is triggered by the Nek2-dependent phosphorylation of C-Nap1. However, the mechanistic consequences of C-Nap1 phosphorylation are unknown. Here, we demonstrate that Nek2 phosphorylates multiple residues within the C-terminal domain of C-Nap1 and, collectively, these phosphorylation events lead to loss of oligomerization and centrosome association. Mutations in non-phosphorylatable residues that make the domain more acidic are sufficient to release C-Nap1 from the centrosome, suggesting that it is an increase in overall negative charge that is required for this process. Importantly, phosphorylation of C-Nap1 also perturbs interaction with the core centriolar protein, Cep135, and interaction of endogenous C-Nap1 and Cep135 proteins is specifically lost in mitosis. We therefore propose that multisite phosphorylation of C-Nap1 by Nek2 perturbs both oligomerization and Cep135 interaction, and this precipitates centrosome disjunction at the onset of mitosis. PMID:24695856

  6. AGU members elected to Academy

    NASA Astrophysics Data System (ADS)

    Six AGU members are among the sixty new members and fifteen foreign associates elected on April 27 to the National Academy of Sciences in recognition of their distinguished and continuing achievements in original research.AGU members elected were AGU Past-President G. Brent Dalrymple of USGS, Menlo Park, Calif.; Donald J . DePaolo, University of California, Berkeley; Ho-Kwang (David) Mao, Carnegie Institution, Washington, D.C.; Mario J . Molina, Massachusetts Institute of Technology, Cambridge; and Alexandra Navrotsky, Princeton University, Princeton, N.J. Elected as foreign associates were Nikolai V. Sobolev, Russian Academy of Sciences, Novosibirsk, and Friedrich H. Busse, University of Bayreuth, Germany.

  7. Naps in school can enhance the duration of declarative memories learned by adolescents.

    PubMed

    Lemos, Nathalia; Weissheimer, Janaina; Ribeiro, Sidarta

    2014-01-01

    Sleep helps the consolidation of declarative memories in the laboratory, but the pro-mnemonic effect of daytime naps in schools is yet to be fully characterized. While a few studies indicate that sleep can indeed benefit school learning, it remains unclear how best to use it. Here we set out to evaluate the influence of daytime naps on the duration of declarative memories learned in school by students of 10-15 years old. A total of 584 students from 6th grade were investigated. Students within a regular classroom were exposed to a 15-min lecture on new declarative contents, absent from the standard curriculum for this age group. The students were then randomly sorted into nap and non-nap groups. Students in the nap group were conducted to a quiet room with mats, received sleep masks and were invited to sleep. At the same time, students in the non-nap group attended regular school classes given by their usual teacher (Experiment I), or English classes given by another experimenter (Experiment II). These 2 versions of the study differed in a number of ways. In Experiment I (n = 371), students were pre-tested on lecture-related contents before the lecture, were invited to nap for up to 2 h, and after 1, 2, or 5 days received surprise tests with similar content but different wording and question order. In Experiment II (n = 213), students were invited to nap for up to 50 min (duration of a regular class); surprise tests were applied immediately after the lecture, and repeated after 5, 30, or 110 days. Experiment I showed a significant ~10% gain in test scores for both nap and non-nap groups 1 day after learning, in comparison with pre-test scores. This gain was sustained in the nap group after 2 and 5 days, but in the non-nap group it decayed completely after 5 days. In Experiment II, the nap group showed significantly higher scores than the non-nap group at all times tested, thus precluding specific conclusions. The results suggest that sleep can be used to enhance

  8. Stable complex formation between HIV Rev and the nucleosome assembly protein, NAP1, affects Rev function

    SciTech Connect

    Cochrane, Alan; Murley, Laura Lea; Gao Mian; Wong, Raymond; Clayton, Kiera; Brufatto, Nicole; Canadien, Veronica; Mamelak, Daniel; Chen, Tricia; Richards, Dawn; Zeghouf, Mahel; Greenblatt, Jack; Burks, Christian; Frappier, Lori

    2009-05-25

    The Rev protein of HIV-1 is essential for HIV-1 proliferation due to its role in exporting viral RNA from the nucleus. We used a modified version of tandem affinity purification (TAP) tagging to identify proteins interacting with HIV-1 Rev in human cells and discovered a prominent interaction between Rev and nucleosome assembly protein 1 (Nap1). This interaction was also observed by specific retention of Nap1 from human cell lysates on a Rev affinity column. Nap1 was found to bind Rev through the Rev arginine-rich domain and altered the oligomerization state of Rev in vitro. Overexpression of Nap1 stimulated the ability of Rev to export RNA, reduced the nucleolar localization of Rev, and affected Rev nuclear import rates. The results suggest that Nap-1 may influence Rev function by increasing the availability of Rev.

  9. Effects of afternoon "siesta" naps on sleep, alertness, performance, and circadian rhythms in the elderly

    NASA Technical Reports Server (NTRS)

    Monk, T. H.; Buysse, D. J.; Carrier, J.; Billy, B. D.; Rose, L. R.

    2001-01-01

    STUDY OBJECTIVES: To determine the effects of a 90-minute afternoon nap regimen on nocturnal sleep, circadian rhythms, and evening alertness and performance levels in the healthy elderly. DESIGN AND SETTING: Nine healthy elderly subjects (4m, 5f, age range 74y-87y) each experienced both nap and no-nap conditions in two studies each lasting 17 days (14 at home, 3 in the laboratory). In the nap condition a 90-minute nap was enforced between 13:30 and 15:00 every day, in the no-nap condition daytime napping was prohibited, and activity encouraged in the 13:30-15:00 interval. The order of the two conditions was counterbalanced. PARTICIPANTS: N/A INTERVENTIONS: N/A MEASUREMENTS: Diary measures, pencil and paper alertness tests, and wrist actigraphy were used at home. In the 72 hour laboratory studies, these measures were augmented by polysomnographic sleep recording, continuous rectal temperature measurement, a daily evening single trial of a Multiple Sleep Latency Test (MSLT), and computerized tests of mood, activation and performance efficiency. RESULTS: By the second week in the "at home" study, an average of 58 minutes of sleep was reported per siesta nap; in the laboratory, polysomnography confirmed an average of 57 minutes of sleep per nap. When nap and no-nap conditions were compared, mixed effects on nocturnal sleep were observed. Diary measures indicated no significant difference in nocturnal sleep duration, but a significant increase (of 38 mins.) in 24-hour Total Sleep Time (TST) when nocturnal sleeps and naps were added together (p<0.025). The laboratory study revealed a decrease of 2.4% in nocturnal sleep efficiency in the nap condition (p<0.025), a reduction of nocturnal Total Sleep Time (TST) by 48 mins. in the nap condition (p<0.001) which resulted primarily from significantly earlier waketimes (p<0.005), but no reliable effects on Wake After Sleep Onset (WASO), delta sleep measures, or percent stages 1 & 2. Unlike the diary study, the laboratory study

  10. Racial Differences in Reported Napping and Nocturnal Sleep in 2- to 8-Year-Old Children

    PubMed Central

    Crosby, Brian; LeBourgeois, Monique K.; Harsh, John

    2010-01-01

    Objectives The objectives of this study were to examine racial differences in reported napping and nighttime sleep of 2- to 8-year-old children, to identify factors accounting for these differences, and to determine if variability in napping was related to psychosocial functioning. Methods Caretakers of 1043 children (73.5% non-Hispanic white; 50.4% male) 2 to 8 years old from a community sample reported on their children’s napping behavior and nighttime sleep. Caretakers of 255 preschool children (3–5 years old) also completed the Behavior Assessment System for Children. Results A more gradual age-related decline in napping was found for black children. At age 8, 39.1% of black children were reported to nap, compared with only 4.9% of white children. Black children also napped significantly more days per week, had shorter average nocturnal sleep durations, and slept significantly less on weekdays than on weekend nights. Despite differences in sleep distribution, total weekly sleep duration (diurnal and nocturnal) was nearly identical for the 2 racial groups at each year of age. Logistic regression analysis revealed that demographic variables were related to but did not fully explain napping differences. Napping in a subset of preschoolers was not significantly related to psychosocial functioning. Conclusions There are remarkable racial differences in reported napping and nighttime sleep patterns beginning as early as age 3 and extending to at least 8 years of age. These differences are independent of commonly investigated demographic factors. Differences in napping behavior do not seem to have psychosocial significance in a sample of preschool children. PMID:15866856

  11. Effects of sleep inertia after daytime naps vary with executive load and time of day.

    PubMed

    Groeger, John A; Lo, June C Y; Burns, Christopher G; Dijk, Derk-Jan

    2011-04-01

    The effects of executive load on working memory performance during sleep inertia after morning or afternoon naps were assessed using a mixed design with nap/wake as a between-subjects factor and morning/afternoon condition as a within-subject factor. Thirty-two healthy adults (mean 22.5 ± 3.0 years) attended two laboratory sessions after a night of restricted sleep (6 hrs), and at first visit, were randomly assigned to the Nap or Wake group. Working memory (n-back) and subjective workload were assessed approximately 5 and 25 minutes after 90-minute morning and afternoon nap opportunities and at the corresponding times in the Wake condition. Actigraphically assessed nocturnal sleep duration, subjective sleepiness, and psychomotor vigilance performance before daytime assessments did not vary across conditions. Afternoon naps showed shorter EEG assessed sleep latencies, longer sleep duration, and more Slow Wave Sleep than morning naps. Working memory performance deteriorated, and subjective mental workload increased at higher executive loadings. After afternoon naps, participants performed less well on more executive-function intensive working memory tasks (i.e., 3-back), but waking and napping participants performed equally well on simpler tasks. After some 30 minutes of cognitive activity, there were no longer performance differences between the waking and napping groups. Subjective Task Difficulty and Mental Effort requirements were less affected by sleep inertia and dissociated from objective measures when participants had napped in the afternoon. We conclude that executive functions take longer to return to asymptotic performance after sleep than does performance of simpler tasks which are less reliant on executive functions. PMID:21463024

  12. Learning by Doing Career Academies

    ERIC Educational Resources Information Center

    Stern, David; Wu, Christopher; Dayton, Charles; Maul, Andrew

    2005-01-01

    This paper's title summarizes the authors' two main aims. For a number of years, the authors have been helping high schools and districts that are attempting to create or improve career academies. Their assistance includes developing the schools' own capacity to keep track of results for students, relying mainly on information that is ordinarily…

  13. Blending Instruction with Khan Academy

    ERIC Educational Resources Information Center

    Cargile, Lori A.

    2015-01-01

    Khan Academy, the free Web-based tutorial program, landed on the education landscape in about 2011, when it was featured on the popular weekly news show "60 Minutes." The program is now used worldwide by more than 10 million learners each month and is used in more than 29,000 classrooms in 216 countries. Are classroom teachers using the…

  14. Carnegie Science Academy Web Site

    NASA Astrophysics Data System (ADS)

    Kotwicki, John; Atzinger, Joe; Turso, Denise

    1997-11-01

    The Carnegie Science Academy is a professional society "For Teens...By Teens" at the Carnegie Science Center in Pittsburgh. The CSA Web Site [ http://csa.clpgh.org ] is designed for teens who have an interest in science and technology. This online or virtual science academy provides resources for teens in high school science classes. The Web site also allows students around the world to participate and communicate with other students, discuss current events in science, share opinions, find answers to questions, or make online friends. Visitors can enjoy the main components of the site or sign up for a free membership which allows access to our chat room for monthly meeting, online newsletter, members forum, and much more. Main components to the site include a spot for cool links and downloads, available for any visitor to download or view. Online exhibits are created by students to examine and publish an area of study and also allow teachers to easily post classroom activities as exhibits by submitting pictures and text. Random Access, the interactive part of the academy, allows users to share ideas and opinions. Planet CSA focuses on current events in science and the academy. In the future the CSA Web site will become a major resource for teens and science teachers providing materials that will allow students to further enhance their interest and experiences in science.

  15. Internship Handbook for Career Academies.

    ERIC Educational Resources Information Center

    Winthrop, Jerauld

    Career academies are high school programs that frame academic learning around a career focus in order to increase student motivation and achievement. They generally have three defining features: a school-within-a-school structure, a college preparation curriculum with a career theme, and partnerships with employers, the community, and higher…

  16. Caliber Schools. Caliber: Beta Academy

    ERIC Educational Resources Information Center

    EDUCAUSE, 2015

    2015-01-01

    Caliber: Beta Academy is reimagining education as we know it, with the belief that the innovations in its model will allow 100% of its students to graduate ready to attend and succeed in a competitive four-year college and beyond. The academic model of the school features personalized learning plans, blended learning for English and math,…

  17. Knowledge Management and the Academy

    ERIC Educational Resources Information Center

    Cain, Timothy J.; Branin, Joseph J.; Sherman, W. Michael

    2008-01-01

    Universities and colleges generate extraordinary quantities of knowledge and innovation, but in many ways the academy struggles to keep pace with the digital revolution. Growing pressures are reshaping how universities must do business--students expecting enhanced access and support, administrators eager to make data-driven strategic decisions,…

  18. INSPIRED High School Computing Academies

    ERIC Educational Resources Information Center

    Doerschuk, Peggy; Liu, Jiangjiang; Mann, Judith

    2011-01-01

    If we are to attract more women and minorities to computing we must engage students at an early age. As part of its mission to increase participation of women and underrepresented minorities in computing, the Increasing Student Participation in Research Development Program (INSPIRED) conducts computing academies for high school students. The…

  19. American Academy of Dental Sleep Medicine

    MedlinePlus

    ... ProSomnus Sleep Technologies Nierman Practice Management ResMed SML-Space Maintainers Laboratory ... Copyright © American Academy of Dental Sleep Medicine, All Rights Reserved. American Academy of Dental Sleep ...

  20. The Segregation Academy and the Law

    ERIC Educational Resources Information Center

    Champagne, Anthony M.

    1973-01-01

    A case study of one private school which functions as a segregation academy'' was done in order to learn more about what segregation academies are, how they operate, and how they relate to the community. (Author/JM)

  1. Reality and dreams: state of the academy.

    PubMed

    Torabi, Mohammad R

    2005-01-01

    These remarks were presented at the opening ceremony of the American Academy of Health Behavior (AAHB) annual scientific conference held in Charleston, SC, in February 2005 by the outgoing president of the Academy. PMID:16336101

  2. Dry pressing technical ceramics

    SciTech Connect

    Lewis, W.A. Jr.

    1996-04-01

    Dry pressing of technical ceramics is a fundamental method of producing high-quality ceramic components. The goals of dry pressing technical ceramics are uniform compact size and green density, consistent part-to-part green density and defect-free compact. Dry pressing is the axial compaction of loosely granulated dry ceramic powders (< 3% free moisture) within a die/punch arrangement. The powder, under pressure, conforms to the specific shape of the punch faces and die. Powder compaction occurs within a rigid-walled die and usually between a top and bottom punch. Press configurations include anvil, rotary, multiple-punch and multiple-action.

  3. Status of automated nap-of-the-earth rotorcraft guidance

    NASA Technical Reports Server (NTRS)

    Coppenbarger, Richard A.; Cheng, Victor H. L.

    1991-01-01

    The status of automated nap-of-the-earth (NOE) flight guidance is discussed by examining two current research efforts that approach the problem of performing obstacle avoidance along a pre-planned course from different perspectives. The first, a real-time guidance system developed by Systems Technology Inc., focuses on the issue of pilot acceptable maneuvers, under the assumption of an ideal, but nonrealizable, obstacle detection system. The second, a system created at NASA Ames, concentrates on the utilization of realistic on-board sensor data for obstacle detection and avoidance-maneuver decisions. This paper examines the strengths and weaknesses of these two approaches, and how they might complement each other. The goal is an automatic NOE system that is both acceptable to pilots and capable of making intelligent use of realistic sensor information and path-selection logic.

  4. Coordinated Action of Nap1 and RSC in Disassembly of Tandem Nucleosomes.

    PubMed

    Prasad, Rashmi; D'Arcy, Sheena; Hada, Arjan; Luger, Karolin; Bartholomew, Blaine

    2016-09-01

    The SWI/SNF and RSC family of ATP-dependent chromatin remodelers disassembles nucleosomes by moving nucleosomes into the vicinity of adjoining nucleosomes. We found that the histone chaperone Nap1 efficiently promotes disassembly of adjacent nucleosomes with which RSC collides and not the disassembly of nucleosomes mobilized by RSC. Nap1 is specific to RSC, as it does not target SWI/SNF, its paralog in Saccharomyces cerevisiae Extensive mutational analysis of Nap1 has revealed that Nap1 affinity for histones H2A-H2B and H3-H4 and its ability to displace histones from DNA are required for Nap1 to enhance RSC-mediated disassembly. Other histone chaperones, such as Vps75, that also bind histones are not able to enhance RSC-mediated disassembly. Our study suggests a mechanism by which Nap1 is recruited to actively transcribed regions and assists in the passage of the transcription complex through chromatin, and it provides a novel mechanism for the coordinated action of RSC and Nap1. PMID:27273866

  5. Sleep to the beat: A nap favours consolidation of timing.

    PubMed

    Verweij, Ilse M; Onuki, Yoshiyuki; Van Someren, Eus J W; Van der Werf, Ysbrand D

    2016-06-01

    Growing evidence suggests that sleep is important for procedural learning, but few studies have investigated the effect of sleep on the temporal aspects of motor skill learning. We assessed the effect of a 90-min day-time nap on learning a motor timing task, using 2 adaptations of a serial interception sequence learning (SISL) task. Forty-two right-handed participants performed the task before and after a 90-min period of sleep or wake. Electroencephalography (EEG) was recorded throughout. The motor task consisted of a sequential spatial pattern and was performed according to 2 different timing conditions, that is, either following a sequential or a random temporal pattern. The increase in accuracy was compared between groups using a mixed linear regression model. Within the sleep group, performance improvement was modeled based on sleep characteristics, including spindle- and slow-wave density. The sleep group, but not the wake group, showed improvement in the random temporal, but especially and significantly more strongly in the sequential temporal condition. None of the sleep characteristics predicted improvement on either general of the timing conditions. In conclusion, a daytime nap improves performance on a timing task. We show that performance on the task with a sequential timing sequence benefits more from sleep than motor timing. More important, the temporal sequence did not benefit initial learning, because differences arose only after an offline period and specifically when this period contained sleep. Sleep appears to aid in the extraction of regularities for optimal subsequent performance. (PsycINFO Database Record PMID:27214501

  6. High School Press Pressures.

    ERIC Educational Resources Information Center

    Rogers, Luella P.

    History shows that the high school press suffers through cycles that reflect economic factors and cultural climates within communities, states, and the nation. The direction of that cycle in the 1960s and early 1970s was toward more open, free-flowing information by a vigorous student press, but those economic and cultural signs now are pointing…

  7. Lyndon Johnson's Press Conferences.

    ERIC Educational Resources Information Center

    Cooper, Stephen

    Because President Lyndon Johnson understood well the publicity value of the American news media, he sought to exploit them. He saw reporters as "torch bearers" for his programs and policies and used the presidential press conference chiefly for promotional purposes. Although he met with reporters often, his press conferences were usually…

  8. Regulation of nap Gene Expression and Periplasmic Nitrate Reductase Activity in the Phototrophic Bacterium Rhodobacter sphaeroides DSM158

    PubMed Central

    Gavira, Mónica; Roldán, M. Dolores; Castillo, Francisco; Moreno-Vivián, Conrado

    2002-01-01

    Bacterial periplasmic nitrate reductases (Nap) can play different physiological roles and are expressed under different conditions depending on the organism. Rhodobacter sphaeroides DSM158 has a Nap system, encoded by the napKEFDABC gene cluster, but nitrite formed is not further reduced because this strain lacks nitrite reductase. Nap activity increases in the presence of nitrate and oxygen but is unaffected by ammonium. Reverse transcription-PCR and Northern blots demonstrated that the napKEFDABC genes constitute an operon transcribed as a single 5.5-kb product. Northern blots and nap-lacZ fusions revealed that nap expression is threefold higher under aerobic conditions but is regulated by neither nitrate nor ammonium, although it is weakly induced by nitrite. On the other hand, nitrate but not nitrite causes a rapid enzyme activation, explaining the higher Nap activity found in nitrate-grown cells. Translational nap′-′lacZ fusions reveal that the napK and napD genes are not efficiently translated, probably due to mRNA secondary structures occluding the translation initiation sites of these genes. Neither butyrate nor caproate increases nap expression, although cells growing phototrophically on these reduced substrates show a very high Nap activity in vivo (nitrite accumulation is sevenfold higher than in medium with malate). Phototrophic growth on butyrate or caproate medium is severely reduced in the NapA− mutants. Taken together, these results indicate that nitrate reduction in R. sphaeroides is mainly regulated at the level of enzyme activity by both nitrate and electron supply and confirm that the Nap system is involved in redox balancing using nitrate as an ancillary oxidant to dissipate excess reductant. PMID:11872721

  9. Identification of Peach NAP Transcription Factor Genes and Characterization of their Expression in Vegetative and Reproductive Organs during Development and Senescence

    PubMed Central

    Li, Fang; Li, Jinjin; Qian, Ming; Han, Mingyu; Cao, Lijun; Liu, Hangkong; Zhang, Dong; Zhao, Caiping

    2016-01-01

    The NAP (NAC-like, activated by AP3/P1) transcription factor belongs to a subfamily of the NAC transcription factor family, and is believed to have an important role in regulating plant growth and development. However, there is very little information about this subfamily in Rosaceous plants. We identified seven NAP genes in the peach genome. PpNAP2 was categorized in the NAP I group, and contained a conserved transcription activation region. The other PpNAP genes belonged to the NAP II group. The expression patterns of the PpNAP genes differed in various organs and developmental stages. PpNAP1 and PpNAP2 were highly expressed in mature and senescing flowers, but not in leaves, fruits, and flower buds. PpNAP3 and PpNAP5 were only expressed in leaves. The PpNAP4 expression level was high in mature and senescing fruits, while PpNAP6 and PpNAP7 expression was up-regulated in mature and senescent leaves and flowers. During the fruit development period, the PpNAP4 and PpNAP6 expression levels rapidly increased during the S1 and S4 stages, which suggests these genes are involved in the first exponential growth phase and fruit ripening. During the fruit ripening and softening period, the PpNAP1, PpNAP4, and PpNAP6 expression levels were high during the early storage period, which was accompanied by a rapid increase in ethylene production. PpNAP1, PpNAP4, and PpNAP6 expression slowly increased during the middle or late storage periods, and peaked at the end of the storage period. Additionally, abscisic acid (ABA)-treated fruits were softer and produced more ethylene than the controls. Furthermore, the PpNAP1, PpNAP4, and PpNAP6 expression levels were higher in ABA-treated fruits. These results suggest that PpNAP1, PpNAP4, and PpNAP6 are responsive to ABA and may regulate peach fruit ripening. PMID:26909092

  10. Identification of Peach NAP Transcription Factor Genes and Characterization of their Expression in Vegetative and Reproductive Organs during Development and Senescence.

    PubMed

    Li, Fang; Li, Jinjin; Qian, Ming; Han, Mingyu; Cao, Lijun; Liu, Hangkong; Zhang, Dong; Zhao, Caiping

    2016-01-01

    The NAP (NAC-like, activated by AP3/P1) transcription factor belongs to a subfamily of the NAC transcription factor family, and is believed to have an important role in regulating plant growth and development. However, there is very little information about this subfamily in Rosaceous plants. We identified seven NAP genes in the peach genome. PpNAP2 was categorized in the NAP I group, and contained a conserved transcription activation region. The other PpNAP genes belonged to the NAP II group. The expression patterns of the PpNAP genes differed in various organs and developmental stages. PpNAP1 and PpNAP2 were highly expressed in mature and senescing flowers, but not in leaves, fruits, and flower buds. PpNAP3 and PpNAP5 were only expressed in leaves. The PpNAP4 expression level was high in mature and senescing fruits, while PpNAP6 and PpNAP7 expression was up-regulated in mature and senescent leaves and flowers. During the fruit development period, the PpNAP4 and PpNAP6 expression levels rapidly increased during the S1 and S4 stages, which suggests these genes are involved in the first exponential growth phase and fruit ripening. During the fruit ripening and softening period, the PpNAP1, PpNAP4, and PpNAP6 expression levels were high during the early storage period, which was accompanied by a rapid increase in ethylene production. PpNAP1, PpNAP4, and PpNAP6 expression slowly increased during the middle or late storage periods, and peaked at the end of the storage period. Additionally, abscisic acid (ABA)-treated fruits were softer and produced more ethylene than the controls. Furthermore, the PpNAP1, PpNAP4, and PpNAP6 expression levels were higher in ABA-treated fruits. These results suggest that PpNAP1, PpNAP4, and PpNAP6 are responsive to ABA and may regulate peach fruit ripening. PMID:26909092

  11. A High School Research-Oriented Academy

    NASA Astrophysics Data System (ADS)

    Adkins, J.

    2011-12-01

    For the past several years Deer Valley High School (Antioch, CA) has hosted a science research academy (DVSRA). This academy has promoted original student primary research in engineering, behavior science, astronomy and physics topics and initiated the school's first entries into science fair and directed a number of students into science careers. During the previous school year the Antioch Unified School District has supported the expansion of the academy into a general research academy encompassing all areas of science and humanities, a move into a new building, purchase of a new planetarium and the development of a collegiate academy model making it easier to integrate the academy into the larger school's academic program. The presentation will discuss the design of the academy and the involvement of students in projects connected to the Teachers in Space Suborbital Flight Opportunity program, NASA's WISE, Mars Global Surveyor, Spitzer, and other missions.

  12. Spread of epidemic Clostridium difficile NAP1/027 in Latin America: case reports in Panama.

    PubMed

    López-Ureña, Diana; Quesada-Gómez, Carlos; Miranda, Erick; Fonseca, Mercedes; Rodríguez-Cavallini, Evelyn

    2014-02-01

    The rate and severity of Clostridium difficile infection (CDI) have been linked to the emergence and spread of the hypervirulent toxigenic strain NAP1/027. This strain has been responsible for large outbreaks in healthcare facilities in North America and Europe and most recently in Latin America. This is the first report of the NAP1 strain in Panama. It suggests that the spread of C. difficile NAP1 throughout Latin America could be a possibility as evidenced in the following case reports. Five isolates typed as NAP1 had tcdA, tcdB, binary toxin gene cdtB and tcdC deletion. All isolates were resistant to clindamycin, fluoroquinolones and rifampicin. Under this scenario, surveillance programmes for CDI should be implemented in public health facilities in Latin America and diagnosis of CDI should be considered, especially in patients with predisposing factors. PMID:24287669

  13. [Insomnia symptoms, daytime naps and physical leisure activities in the elderly: FIBRA Study Campinas].

    PubMed

    Monteiro, Natália Tonon; Neri, Anita Liberalesso; Coelim, Maria Filomena

    2014-04-01

    The practice of physical activities contributes to reducing the risk of chronic diseases and improves sleep patterns in the elderly. This research aimed to investigate the association between insomnia symptoms and daytime nap and the participation in physical leisure activities in elderly community residents. Data from the Studies Network of the Fragility in Brazilian Elderly (Campinas site), were used. Information from 689 elderly was analyzed, regarding sociodemographic characterization, physical leisure activity, occurrence of daytime napping and its duration, symptoms of insomnia and use of sleep medication. A significant association was found between the practice of walking and the daytime nap of short duration. Studies indicate that a short nap can benefit the quality of sleep and health of the elderly. Therefore, promoting the practice of walking can be a nursing intervention that favors the sleep patterns of the elderly. PMID:24918882

  14. Physical Fitness of Police Academy Cadets: Baseline Characteristics and Changes During a 16-Week Academy

    PubMed Central

    Sherman, Ross A.; Crawley, William R.; Cosio-Lima, Ludmila M.

    2016-01-01

    Abstract Crawley, AA, Sherman, RA, Crawley, WR, and Cosio-Lima, LM. Physical fitness of police academy cadets: baseline characteristics and changes during a 16-week academy. J Strength Cond Res 30(5): 1416–1424, 2016—Police academies traditionally emphasize the importance of being physically fit. The purpose of this research was to determine cadet baseline physical fitness characteristics and assess effectiveness of a 16-week training program. Sixty-eight cadets (61 men, 7 women) volunteered to have baseline physical fitness characteristics assessed, and 55 cadets (49 men, 6 women) completed further testing at weeks 8 and 16. The testing comprised hand grip (strength), arm crank (upper-body power), 30 seconds Wingate (lower body power), sum of skinfolds and percentage body fat (body composition), 40-yard dash (sprint speed), 1 repetition maximum bench press (strength), T-test (agility), and sit-and-reach (flexibility). In addition, cadets completed standardized state testing (push-ups, sit-ups, vertical jump, and half-mile shuttle run). The training program consisted of 1 hour sessions, 3 d·wk−1, including aerobic, plyometrics, body weight, and resistance exercise. Significant changes were found in agility (p < 0.01), upper-body and lower-body peak power (p ≤ 0.05), sit-ups (p < 0.01), push-ups (p ≤ 0.05) across the first 8 weeks, and in agility (p ≤ 0.05), lower-body peak power (p ≤ 0.05), sit-ups (p < 0.01), push-ups (p ≤ 0.05), half-mile shuttle run (p < 0.01) across the full 16 weeks. However, none of the variables showed significant change across the second half of the program (weeks 8–16). A number of individual parameters of physical fitness showed evidence of improvement in the first 8 weeks, whereas none of the variables showed significant improvement in the second 8 weeks. This suggests modifications could be made to increase overall effectiveness of cadet physical training specifically after the 8-week mark. PMID:26466133

  15. A Daytime Nap Facilitates Generalization of Word Meanings in Young Toddlers

    PubMed Central

    Horváth, Klára; Liu, Siying; Plunkett, Kim

    2016-01-01

    Study Objectives: One of the key processes in language development is generalization—the selection and extension of relevant features and information to similar objects and concepts. Little is known about how sleep influences generalization, and studies on the topic are inconclusive. Our aim was to investigate how a nap affects generalization in 16-mo-olds. We hypothesized that a nap is necessary for successful generalization of word meanings. Methods: Twenty-eight 16-mo-old, typically developing toddlers were randomly assigned to nap and wake groups. We trained toddlers with two novel object-word pairs and tested their initial ability to generalize. Toddlers took part in an intermodal preferential looking task, in which they were shown different colored versions of the original objects and heard one of the trained labels. If toddlers understand the label, they are expected to increase their looking time to the target. Looking behavior was measured with an automated eye tracker. Afterward, the nap group went to sleep, while the wake group stayed awake for approximately 2 h. We then repeated the test of their performance on the generalization task. Results: A significant interaction of group and session was found in preferential looking. The performance of the nap group increased after the nap, whereas that of the wake group did not change. Conclusions: Our results suggest that napping improves generalization in toddlers. Citation: Horváth K, Liu S, Plunkett K. A daytime nap facilitates generalization of word meanings in young toddlers. SLEEP 2016;39(1):203–207. PMID:26237777

  16. Napping and Nighttime Sleep: Findings From an Occupation-Based Intervention

    PubMed Central

    Fogelberg, Donald; Sleight, Alix; Mallinson, Trudy; Vigen, Cheryl; Blanchard, Jeanine; Carlson, Mike; Clark, Florence

    2016-01-01

    OBJECTIVE. To describe sleeping behaviors and trends over time among an ethnically diverse group of community-living older adults. METHOD. A descriptive secondary data analysis of a subsample (n = 217) from the Lifestyle Redesign randomized controlled trial was done to explore baseline napping and sleeping patterns as well as 6-mo changes in these outcomes. RESULTS. At baseline, the average time sleeping was 8.2 hr daily (standard deviation = 1.7). Among all participants, 29% reported daytime napping at baseline, of which 36% no longer napped at follow-up. Among participants who stopped napping, those who received an occupation-based intervention (n = 98) replaced napping time with nighttime sleep, and those not receiving an intervention (n = 119) experienced a net loss of total sleep (p < .05). CONCLUSION. Among participants who stopped napping, the occupation-based intervention may be related to enhanced sleep. More research examining the role of occupation-based interventions in improving sleep is warranted. PMID:27294991

  17. Histone Chaperone NAP1 Mediates Sister Chromatid Resolution by Counteracting Protein Phosphatase 2A

    PubMed Central

    Kan, Tsung-Wai; Chalkley, Gillian E.; Sap, Karen; Bezstarosti, Karel; Demmers, Jeroen A.; Ozgur, Zeliha; van Ijcken, Wilfred F. J.; Verrijzer, C. Peter

    2013-01-01

    Chromosome duplication and transmission into daughter cells requires the precisely orchestrated binding and release of cohesin. We found that the Drosophila histone chaperone NAP1 is required for cohesin release and sister chromatid resolution during mitosis. Genome-wide surveys revealed that NAP1 and cohesin co-localize at multiple genomic loci. Proteomic and biochemical analysis established that NAP1 associates with the full cohesin complex, but it also forms a separate complex with the cohesin subunit stromalin (SA). NAP1 binding to cohesin is cell-cycle regulated and increases during G2/M phase. This causes the dissociation of protein phosphatase 2A (PP2A) from cohesin, increased phosphorylation of SA and cohesin removal in early mitosis. PP2A depletion led to a loss of centromeric cohesion. The distinct mitotic phenotypes caused by the loss of either PP2A or NAP1, were both rescued by their concomitant depletion. We conclude that the balanced antagonism between NAP1 and PP2A controls cohesin dissociation during mitosis. PMID:24086141

  18. Diminished nap effects on memory consolidation are seen under oral contraceptive use.

    PubMed

    Genzel, Lisa; Bäurle, Anna; Potyka, Alina; Wehrle, Renate; Adamczyk, Marek; Friess, Elisabeth; Steiger, Axel; Dresler, Martin

    2014-01-01

    Many young females take exogenous hormones as oral contraceptive (OC), a condition rarely controlled for in studies on sleep and memory consolidation even though sex hormones influence consolidation. This study investigated the effects of OCs on sleep-related consolidation of a motor and declarative task, utilizing a daytime nap protocol. Fifteen healthy, young females taking OCs came to the sleep lab for three different conditions: nap with previous learning, wake with previous learning and nap without learning. They underwent each condition twice, once during the "pill-active" weeks and once during the "pill-free" week, resulting in 6 visits. In all conditions, participants showed a significant off-line consolidation effect, independent of pill week or nap/wake condition. There were no significant differences in sleep stage duration, spindle activity or spectral EEG frequency bands between naps with or without the learning condition. The present data showed a significant off-line enhancement in memory irrespective of potential beneficial effects of a nap. In comparison to previous studies, this may suggest that the use of OCs may enhance off-line memory consolidation in motor and verbal tasks per se. These results stress the importance to control for the use of OCs in studies focusing on memory performance. PMID:25720656

  19. Risperidone and NAP protect cognition and normalize gene expression in a schizophrenia mouse model

    PubMed Central

    Vaisburd, Sinaya; Shemer, Zeev; Yeheskel, Adva; Giladi, Eliezer; Gozes, Illana

    2015-01-01

    Mutated disrupted in schizophrenia 1 (DISC1), a microtubule regulating protein, leads to schizophrenia and other psychiatric illnesses. It is hypothesized that microtubule stabilization may provide neuroprotection in schizophrenia. The NAP (NAPVSIPQ) sequence of activity-dependent neuroprotective protein (ADNP) contains the SxIP motif, microtubule end binding (EB) protein target, which is critical for microtubule dynamics leading to synaptic plasticity and neuroprotection. Bioinformatics prediction for FDA approved drugs mimicking SxIP-like motif which displace NAP-EB binding identified Risperidone. Risperidone or NAP effectively ameliorated object recognition deficits in the mutated DISC1 mouse model. NAP but not Risperidone, reduced anxiety in the mutated mice. Doxycycline, which blocked the expression of the mutated DISC1, did not reverse the phenotype. Transcripts of Forkhead-BOX P2 (Foxp2), a gene regulating DISC1 and associated with human ability to acquire a spoken language, were increased in the hippocampus of the DISC1 mutated mice and were significantly lowered after treatment with NAP, Risperidone, or the combination of both. Thus, the combination of NAP and standard of care Risperidone in humans may protect against language disturbances associated with negative and cognitive impairments in schizophrenia. PMID:26553741

  20. Risperidone and NAP protect cognition and normalize gene expression in a schizophrenia mouse model.

    PubMed

    Vaisburd, Sinaya; Shemer, Zeev; Yeheskel, Adva; Giladi, Eliezer; Gozes, Illana

    2015-01-01

    Mutated disrupted in schizophrenia 1 (DISC1), a microtubule regulating protein, leads to schizophrenia and other psychiatric illnesses. It is hypothesized that microtubule stabilization may provide neuroprotection in schizophrenia. The NAP (NAPVSIPQ) sequence of activity-dependent neuroprotective protein (ADNP) contains the SxIP motif, microtubule end binding (EB) protein target, which is critical for microtubule dynamics leading to synaptic plasticity and neuroprotection. Bioinformatics prediction for FDA approved drugs mimicking SxIP-like motif which displace NAP-EB binding identified Risperidone. Risperidone or NAP effectively ameliorated object recognition deficits in the mutated DISC1 mouse model. NAP but not Risperidone, reduced anxiety in the mutated mice. Doxycycline, which blocked the expression of the mutated DISC1, did not reverse the phenotype. Transcripts of Forkhead-BOX P2 (Foxp2), a gene regulating DISC1 and associated with human ability to acquire a spoken language, were increased in the hippocampus of the DISC1 mutated mice and were significantly lowered after treatment with NAP, Risperidone, or the combination of both. Thus, the combination of NAP and standard of care Risperidone in humans may protect against language disturbances associated with negative and cognitive impairments in schizophrenia. PMID:26553741

  1. Trashing the Press.

    ERIC Educational Resources Information Center

    McMasters, Paul

    1994-01-01

    Discusses ominous assaults on press freedom on college campuses across the United States. Laments the lack of concern about First Amendment issues involved in these incidents, in which student newspapers have been stolen, trashed, and burned. (SR)

  2. Midday Naps and the Risk of Coronary Artery Disease: Results of the Heinz Nixdorf Recall Study

    PubMed Central

    Stang, Andreas; Dragano, Nico; Moebus, Susanne; Möhlenkamp, Stefan; Schmermund, Axel; Kälsch, Hagen; Erbel, Raimund; Jöckel, Karl-Heinz

    2012-01-01

    Study Objectives: Several studies have assessed the association between midday nap and cardiovascular outcomes and reported heterogenous results. Concern exists that confounding might have distorted these results and contributed to discrepancies among them. This study prospectively examines the association between midday nap habits and the occurrence of coronary artery disease in a non-Mediterranean population. Participants: The baseline examination of 4,123 participants aged 45–75 years. Measurements: Measurements included interviews, physical examinations, laboratory tests, and electron beam computed tomography. We studied the influence of midday nap habits on risk of coronary artery disease. We adjusted for several potential confounders including measures of subclinical atherosclerosis—such as coronary calcium score and ankle brachial index—at baseline. Cardiac events during a median follow-up of 8.1 years were defined as nonfatal myocardial infarction and sudden cardiac death. Results: Overall, 135 of 4,123 subjects (3.3%) either suffered from acute myocardial infarction (81 subjects) or died due to a sudden cardiac death (54 subjects) during follow-up. After adjustment for several confounders including measures of subclinical atherosclerosis, regular long (> 60 min) midday nap was associated with an increased hazard ratio of cardiac events (hazard ratio 2.12, 95% confidence interval 1.11–4.05). Conclusions: As our detailed confounder analyses showed, confounding is not the sole explanation for this finding. Future research on midday naps should focus on biological mechanisms that may be responsible for increasing the risk of coronary artery disease among subjects taking regular long midday naps. Citation: Stang A; Dragano N; Moebus S; Möhlenkamp S; Schmermund A; Kälsch H; Erbel R; Jöckel KH. Midday naps and the risk of coronary artery disease: results of the Heinz Nixdorf Recall Study. SLEEP 2012;35(12):1705–1712. PMID:23204613

  3. Predictive Modeling of the Academic Performance of USAF Academy Preparatory School Graduates at the USAF Academy.

    ERIC Educational Resources Information Center

    Anderson, Kenneth R.

    This study used linear models developed by stepwise multiple regression to examine the relationship between performance at the United States Air Force Academy Preparatory School and subsequent grade point average (GPA) at the USAF Academy. Data collected on Prep School graduates in the Academy classes of '71 through '77 who had completed at least…

  4. The Career Academy Concept. OJJDP Fact Sheet.

    ERIC Educational Resources Information Center

    Coffee, Joseph N.; Pestridge, Scott

    Career academies are schools within schools that link students with peers, teachers, and community partners in a disciplined environment, thereby fostering academic success and mental and emotional health. The career academy concept includes the following three key elements: (1) small learning communities; (2) a college preparatory curriculum with…

  5. Naval Academy Continues Its Diversity Trend

    ERIC Educational Resources Information Center

    Cooper, Kenneth J.

    2009-01-01

    Sixty years after graduating its first Black midshipman, Wesley Brown, the U.S. Naval Academy has admitted its most diverse class, which boasts the largest numbers and percentages of African-Americans and Hispanics ever to enter Annapolis. The academy has touted the racial and ethnic composition of the class of 2013 as the result of aggressive…

  6. The Academy for Positive Peer Culture

    ERIC Educational Resources Information Center

    Laursen, Erik K.

    2010-01-01

    Positive Peer Culture [PPC] creates a pro-social climate in schools and youth programs by enlisting youth in helping their peers. Research and training in PPC is coordinated by the Academy for Positive Peer Culture. Established in 2006, the Academy provides networking and is a clearinghouse for resources, training, and consultation for PPC. It…

  7. Student Standards for the Junior Academy.

    ERIC Educational Resources Information Center

    Edison Project, New York, NY.

    This handbook describes the curriculum and academic standards of the Edison Project's Junior Academy for students aged 11-14. The academy features a student-centered environment, daily meetings in advisory groups, family involvement, exposure to the "Greats"--world-changing ideas, outstanding works of art from different cultures, and key…

  8. D-SAL and NAP: Two Peptides Sharing a SIP Domain.

    PubMed

    Gozes, Illana; Sragovich, Shlomo; Schirer, Yulie; Idan-Feldman, Anat

    2016-06-01

    NAPVSIPQ (NAP) and all D-amino acid SALLRSIPA (D-SAL) are neuroprotective peptides derived from activity-dependent neuroprotective protein (ADNP) and activity-dependent neurotrophic factor (ADNF), respectively. Both proteins were shown to protect against cognitive impairment, using different animal models and to increase neuronal survival following exposure to neurotoxins. NAP was extensively tested and found to increase microtubule stability, protect axonal transport, and inhibit apoptosis. Here, we aimed to further evaluate and correlate effects at the behavioral level, in a rat model of diabetes. Diabetes is primarily a metabolic disorder which presents secondary neurological manifestations. Diabetes induces peripheral nervous system damage which is translated into impaired sensory perception and is termed diabetic neuropathy. Diabetes-related central nervous system damage causes cognitive decline. The behavioral study aimed to evaluate the effect of NAP and D-SAL on peripheral neuropathy and cognitive decline. Peripheral neuropathy was tested by measuring the response to a thermal stimulus, and cognitive ability was measured by a social memory test and a spatial memory test using long- and short-term dependent tasks and a reference memory task. Results indicated an immediate sensory neuropathy in the diabetic model, which was prevented by both peptides and a later neuropathic phase, prevented only by NAP treatment. Cognitive tests revealed impaired performance in both social and spatial memory tests in the diabetes model. Each of the peptides improved different aspects of cognitive behavior, with NAP being more potent than D-SAL. Mechanistically, both NAP and SAL contain a SIP (SxIP) domain that has been shown to interact with microtubule end-binding proteins (EBs). Specifically, we have previously shown a direct interaction of NAP with EB1 and EB3; we have further shown an interaction of the NAP-derived 4 amino acid SKIP peptide with EB3, stimulating axonal

  9. The Arecibo Observatory Space Academy

    NASA Astrophysics Data System (ADS)

    Rodriguez-Ford, Linda A.; Zambrano-Marin, Luisa; Petty, Bryan M.; Sternke, Elizabeth; Ortiz, Andrew M.; Rivera-Valentin, Edgard G.

    2015-11-01

    The Arecibo Observatory Space Academy (AOSA) is a ten (10) week pre-college research program for students in grades 9-12. Our mission is to prepare students for academic and professional careers by allowing them to receive an independent and collaborative research experience on topics related to space and aide in their individual academic and social development. Our objectives are to (1) Supplement the student’s STEM education via inquiry-based learning and indirect teaching methods, (2) Immerse students in an ESL environment, further developing their verbal and written presentation skills, and (3) To foster in every student an interest in science by exploiting their natural curiosity and knowledge in order to further develop their critical thinking and investigation skills. AOSA provides students with the opportunity to share lectures with Arecibo Observatory staff, who have expertise in various STEM fields. Each Fall and Spring semester, selected high school students, or Cadets, from all over Puerto Rico participate in this Saturday academy where they receive experience designing, proposing, and carrying out research projects related to space exploration, focusing on four fields: Physics/Astronomy, Biology, Engineering, and Sociology. Cadets get the opportunity to explore their topic of choice while practicing many of the foundations of scientific research with the goal of designing a space settlement, which they present at the NSS-NASA Ames Space Settlement Design Contest. At the end of each semester students present their research to their peers, program mentors, and Arecibo Observatory staff. Funding for this program is provided by NASA SSERVI-LPI: Center for Lunar Science and Exploration with partial support from the Angel Ramos Visitor Center through UMET and management by USRA.

  10. Conservation of imprinting of MKRN3 and NAP1L5 in rabbits.

    PubMed

    Yuan, L; Lai, L; Duan, F; Chen, M; Deng, J; Li, Z

    2016-08-01

    Maternally imprinted genes of makorin ring finger protein 3 (MKRN3) and nucleosome assembly protein 1-like 5 (NAP1L5) have been identified in many species but have not yet been investigated in rabbits. In this study, a polymorphism-based approach and bisulfite-sequencing PCR (BSP) were used to determine the imprinting status of MKRN3 and NAP1L5 in rabbits. The single nucleotide polymorphism (SNP)-based sequencing results demonstrated that MKRN3 and NAP1L5 were expressed preferentially from the paternal allele. Furthermore, the BSP results showed the gamete-specific methylation patterns and hemimethylation in brain and full methylation in liver were observed in MKRN3 and NAP1L5 respectively. Thus, we provide the first evidence that MKRN3 and NAP1L5 are paternally expressed genes and that the CpG islands located in the promoter region may be the putative differentially methylated region of these two genes in rabbits. PMID:27091003

  11. Sleeping pattern of kindergartners and nursery school children: function of daytime nap.

    PubMed

    Fukuda, Kazuhiko; Sakashita, Yukine

    2002-02-01

    With a questionnaire answered by parents this study investigated the sleeping pattern of children attending kindergartens or nursery schools and the function of an afternoon nap. Sleeping pattern was investigated by a questionnaire with 441 young children (229 boys and 212 girls) attending kindergartens or nursery schools at the ages of 3 to 6 years old. Nighttime sleep did not show any significant change, while daytime naps decreased drastically and almost disappeared by the age of 6. Nursery school children went to bed later at night, so nighttime sleep was shorter than that of kindergartners. They also reported having more 'difficulty to fall asleep', more frequent 'staying-up at late night', less 'not getting enough sleep', worse 'mood at rising', and more 'unwillingness to go to their schools'. To investigate whether afternoon naps, which are routine at Japanese nursery schools, can compensate for sleep insufficiency on the previous night and whether they have the effect of delaying the onset of the subsequent nighttime sleep, we compared sleep duration on the previous night and the sleep onset time between the days with and without an afternoon nap. The afternoon nap appeared to cause delayed sleep onset but was not a result of sleep deficiency. PMID:11883566

  12. NAP1 family histone chaperones are required for somatic homologous recombination in Arabidopsis.

    PubMed

    Gao, Juan; Zhu, Yan; Zhou, Wangbin; Molinier, Jean; Dong, Aiwu; Shen, Wen-Hui

    2012-04-01

    Homologous recombination (HR) is essential for maintaining genome integrity and variability. To orchestrate HR in the context of chromatin is a challenge, both in terms of DNA accessibility and restoration of chromatin organization after DNA repair. Histone chaperones function in nucleosome assembly/disassembly and could play a role in HR. Here, we show that the NUCLEOSOME ASSEMBLY PROTEIN1 (NAP1) family histone chaperones are required for somatic HR in Arabidopsis thaliana. Depletion of either the NAP1 group or NAP1-RELATED PROTEIN (NRP) group proteins caused a reduction in HR in plants under normal growth conditions as well as under a wide range of genotoxic or abiotic stresses. This contrasts with the hyperrecombinogenic phenotype caused by the depletion of the CHROMATIN ASSEMBLY FACTOR-1 (CAF-1) histone chaperone. Furthermore, we show that the hyperrecombinogenic phenotype caused by CAF-1 depletion relies on NRP1 and NRP2, but the telomere shortening phenotype does not. Our analysis of DNA lesions, H3K56 acetylation, and expression of DNA repair genes argues for a role of NAP1 family histone chaperones in nucleosome disassembly/reassembly during HR. Our study highlights distinct functions for different families of histone chaperones in the maintenance of genome stability and establishes a crucial function for NAP1 family histone chaperones in somatic HR. PMID:22534127

  13. Sleep extension versus nap or coffee, within the context of 'sleep debt'.

    PubMed

    Horne, James; Anderson, Clare; Platten, Charlotte

    2008-12-01

    Though extended night-time sleep mostly reduces the 'afternoon dip', little is known about evening benefits to alertness, or about comparisons with an afternoon nap or caffeine. Twenty healthy carefully screened adults, normal waking alertness levels, underwent four counterbalanced conditions: usual night sleep; night sleep extended<90 min (usual bed-time); up to 20 min afternoon nap; and 150 mg afternoon caffeine (versus decaffeinated coffee). Sleepiness was measured by afternoon and evening multiple sleep latency test (MSLTs), longer psychomotor vigilance test (PVT) sessions and a subjective sleepiness scale. Sleep was extended by average of 74 min, and all participants could nap 15-20 min. Sleep extension had little effect on PVT determined modest levels of morning sleepiness. Afternoon and evening MSLTs showed all active treatments significantly reduced the 'dip', with nap most effective until mid-evening; next effective was caffeine, then extension. Late evening sleepiness and subsequent sleep did not differ between conditions. Arguably, participants may have experienced some 'sleep debt', given they extended sleep and reflected some sleepiness within settings sensitive to sleepiness. Nevertheless, extended sleep seemed largely superfluous and inefficient in reducing modest levels of sleepiness when compared with a timely nap, and even caffeine. Sleep, such as food and fluid intakes, can be taken to excess of real biological needs, and for many healthy adults, there is a level of modest daytime sleepiness, only unmasked by very sensitive laboratory measures. It may reflect a requirement for more sleep or simply be within the bounds of normal acceptability. PMID:19021851

  14. Characterization of the Nencki Affective Picture System by discrete emotional categories (NAPS BE).

    PubMed

    Riegel, Monika; Żurawski, Łukasz; Wierzba, Małgorzata; Moslehi, Abnoss; Klocek, Łukasz; Horvat, Marko; Grabowska, Anna; Michałowski, Jarosław; Jednoróg, Katarzyna; Marchewka, Artur

    2016-06-01

    The Nencki Affective Picture System (NAPS; Marchewka, Żurawski, Jednoróg, & Grabowska, Behavior Research Methods, 2014) is a standardized set of 1,356 realistic, high-quality photographs divided into five categories (people, faces, animals, objects, and landscapes). NAPS has been primarily standardized along the affective dimensions of valence, arousal, and approach-avoidance, yet the characteristics of discrete emotions expressed by the images have not been investigated thus far. The aim of the present study was to collect normative ratings according to categorical models of emotions. A subset of 510 images from the original NAPS set was selected in order to proportionally cover the whole dimensional affective space. Among these, using three available classification methods, we identified images eliciting distinguishable discrete emotions. We introduce the basic-emotion normative ratings for the Nencki Affective Picture System (NAPS BE), which will allow researchers to control and manipulate stimulus properties specifically for their experimental questions of interest. The NAPS BE system is freely accessible to the scientific community for noncommercial use as supplementary materials to this article. PMID:26205422

  15. Motor Performance Is not Enhanced by Daytime Naps in Older Adults

    PubMed Central

    Backhaus, Winifried; Braass, Hanna; Renné, Thomas; Gerloff, Christian; Hummel, Friedhelm C.

    2016-01-01

    The impact of sleep on motor learning in the aging brain was investigated using an experimental diurnal nap setup. As the brain ages several components of learning as well as motor performance change. In addition, aging is also related to sleep architectural changes. This combination of slowed learning processes and impaired sleep behavior raises the question of whether sleep can enhance learning and specifically performance of procedural tasks in healthy, older adults. Previous research was able to show sleep-dependent consolidation overnight for numerous tasks in young adults. Some of these study findings can also be replicated for older adults. This study aims to clarify whether sleep-dependent consolidation can also be found during shorter periods of diurnal sleep. The impact of midday naps on motor consolidation was analyzed by comparing procedural learning using a sequence and a motor adaptation task, in a crossover fashion in healthy, non-sleep deprived, older adults randomly subjected to wake (45 min), short nap (10–20 min sleep) or long nap (50–70 min sleep) conditions. Older adults exhibited learning gains, these were not found to be sleep-dependent in either task. The results suggest that daytime naps do not have an impact on performance and motor learning in an aging population. PMID:27303292

  16. Motor Performance Is not Enhanced by Daytime Naps in Older Adults.

    PubMed

    Backhaus, Winifried; Braass, Hanna; Renné, Thomas; Gerloff, Christian; Hummel, Friedhelm C

    2016-01-01

    The impact of sleep on motor learning in the aging brain was investigated using an experimental diurnal nap setup. As the brain ages several components of learning as well as motor performance change. In addition, aging is also related to sleep architectural changes. This combination of slowed learning processes and impaired sleep behavior raises the question of whether sleep can enhance learning and specifically performance of procedural tasks in healthy, older adults. Previous research was able to show sleep-dependent consolidation overnight for numerous tasks in young adults. Some of these study findings can also be replicated for older adults. This study aims to clarify whether sleep-dependent consolidation can also be found during shorter periods of diurnal sleep. The impact of midday naps on motor consolidation was analyzed by comparing procedural learning using a sequence and a motor adaptation task, in a crossover fashion in healthy, non-sleep deprived, older adults randomly subjected to wake (45 min), short nap (10-20 min sleep) or long nap (50-70 min sleep) conditions. Older adults exhibited learning gains, these were not found to be sleep-dependent in either task. The results suggest that daytime naps do not have an impact on performance and motor learning in an aging population. PMID:27303292

  17. Glutamylation of Nap1 modulates histone H1 dynamics and chromosome condensation in Xenopus.

    PubMed

    Miller, Kelly E; Heald, Rebecca

    2015-04-27

    Linker histone H1 is required for mitotic chromosome architecture in Xenopus laevis egg extracts and, unlike core histones, exhibits rapid turnover on chromatin. Mechanisms regulating the recruitment, deposition, and dynamics of linker histones in mitosis are largely unknown. We found that the cytoplasmic histone chaperone nucleosome assembly protein 1 (Nap1) associates with the embryonic isoform of linker histone H1 (H1M) in egg extracts. Immunodepletion of Nap1 decreased H1M binding to mitotic chromosomes by nearly 50%, reduced H1M dynamics as measured by fluorescence recovery after photobleaching and caused chromosome decondensation similar to the effects of H1M depletion. Defects in H1M dynamics and chromosome condensation were rescued by adding back wild-type Nap1 but not a mutant lacking sites subject to posttranslational modification by glutamylation. Nap1 glutamylation increased the deposition of H1M on sperm nuclei and chromatin-coated beads, indicating that charge-shifting posttranslational modification of Nap1 contributes to H1M dynamics that are essential for higher order chromosome architecture. PMID:25897082

  18. American Academy of Facial Plastic and Reconstructive Surgery

    MedlinePlus

    ... Contact Us Shopping Cart American Academy of Facial Plastic and Reconstructive Surgery Home Meetings & Courses Find a ... About Our Academy The American Academy of Facial Plastic and Reconstructive Surgery is the world's largest specialty ...

  19. Press-On Optics

    ERIC Educational Resources Information Center

    Thorson, Jon C.

    1972-01-01

    The article discusses the design, application, and clinical uses of press-on optics which are descirbed as 1 millimeter thick, flexible lenses or prisms that may be produced in virtually any desired plus or minus dioptric power as ophthalmic lenses, or in any range of usable prism diopter power. (GW)

  20. Meet the Press

    ERIC Educational Resources Information Center

    Quick, Brian L.

    2004-01-01

    Objective: To field questions from a room of students simulating a press conference. Type of speech: Impromptu. Point value: 10 participation points. To receive all 10 points, students must (1) address three questions from the lectern and ask three questions from their seat (3 points), (2) respond thoroughly to each question by providing a…

  1. Optically Aligned Drill Press

    NASA Technical Reports Server (NTRS)

    Adderholdt, Bruce M.

    1994-01-01

    Precise drill press equipped with rotary-indexing microscope. Microscope and drill exchange places when turret rotated. Microscope axis first aligned over future hole, then rotated out of way so drill axis assumes its precise position. New procedure takes less time to locate drilling positions and produces more accurate results. Apparatus adapted to such other machine tools as milling and measuring machines.

  2. Drill Press Work Sample.

    ERIC Educational Resources Information Center

    Shawsheen Valley Regional Vocational-Technical High School, Billerica, MA.

    This manual contains a work sample intended to assess a handicapped student's interest in and to screen interested students into a training program in basic machine shop I. (The course is based on the entry level of the drill press operator.) Section 1 describes the assessment, correlates the work performed and worker traits required for…

  3. Clinical Utility of Laboratory Detection of Clostridium difficile Strain BI/NAP1/027

    PubMed Central

    Gerding, Dale N.

    2015-01-01

    Clostridium difficile strain BI/NAP1/027 is associated with increased C. difficile infection (CDI) rates and severity, and the efficacy of some CDI therapies may be strain dependent. Although cultured C. difficile isolates can be reliably subtyped by various methods, the long turnaround times, high cost, and limited availability of strain typing preclude their routine use. Nucleic acid amplification tests identify BI/NAP1/027 rapidly from stool, but the emergence of closely related strains compromises test specificity. Although detection of epidemiologically significant pathogens is generally useful for infection control programs, specific data supporting use of rapid detection of BI/NAP1/027 as an infection control tool are still awaited. PMID:26511742

  4. Clinical Utility of Laboratory Detection of Clostridium difficile Strain BI/NAP1/027.

    PubMed

    Kociolek, Larry K; Gerding, Dale N

    2016-01-01

    Clostridium difficile strain BI/NAP1/027 is associated with increased C. difficile infection (CDI) rates and severity, and the efficacy of some CDI therapies may be strain dependent. Although cultured C. difficile isolates can be reliably subtyped by various methods, the long turnaround times, high cost, and limited availability of strain typing preclude their routine use. Nucleic acid amplification tests identify BI/NAP1/027 rapidly from stool, but the emergence of closely related strains compromises test specificity. Although detection of epidemiologically significant pathogens is generally useful for infection control programs, specific data supporting use of rapid detection of BI/NAP1/027 as an infection control tool are still awaited. PMID:26511742

  5. Rapid-Eye-Movement-Sleep (REM) Associated Enhancement of Working Memory Performance after a Daytime Nap

    PubMed Central

    Lau, Kristy Nga Ting; Hui, Florence Wai Ying; Tseng, Chia-huei

    2015-01-01

    The main objective was to study the impact of a daytime sleep opportunity on working memory and the mechanism behind such impact. This study adopted an experimental design in a sleep research laboratory. Eighty healthy college students (Age:17-23, 36 males) were randomized to either have a polysomnography-monitored daytime sleep opportunity (Nap-group, n=40) or stay awake (Wake-group, n=40) between the two assessment sessions. All participants completed a sleep diary and wore an actigraph-watch for 5 days before and one day after the assessment sessions. They completed the state-measurement of sleepiness and affect, in addition to a psychomotor vigilance test and a working memory task before and after the nap/wake sessions. The two groups did not differ in their sleep characteristics prior to and after the lab visit. The Nap-group had higher accuracy on the working memory task, fewer lapses on the psychomotor vigilance test and lower state-sleepiness than the Wake-group. Within the Nap-group, working memory accuracy was positively correlated with duration of rapid eye movement sleep (REM) and total sleep time during the nap. Our findings suggested that “sleep gain” during a daytime sleep opportunity had significant positive impact on working memory performance, without affecting subsequent nighttime sleep in young adult, and such impact was associated with the duration of REM. While REM abnormality has long been noted in pathological conditions (e.g. depression), which are also presented with cognitive dysfunctions (e.g. working memory deficits), this was the first evidence showing working memory enhancement associated with REM in daytime napping in college students, who likely had habitual short sleep duration but were otherwise generally healthy. PMID:25970511

  6. Fatigue on the flight deck: the consequences of sleep loss and the benefits of napping.

    PubMed

    Hartzler, Beth M

    2014-01-01

    The detrimental effects of fatigue in aviation are well established, as evidenced by both the number of fatigue-related mishaps and numerous studies which have found that most pilots experience a deterioration in cognitive performance as well as increased stress during the course of a flight. Further, due to the nature of the average pilot's work schedule, with frequent changes in duty schedule, early morning starts, and extended duty periods, fatigue may be impossible to avoid. Thus, it is critical that fatigue countermeasures be available which can help to combat the often overwhelming effects of sleep loss or sleep disruption. While stimulants such as caffeine are typically effective at maintaining alertness and performance, such countermeasures do nothing to address the actual source of fatigue - insufficient sleep. Consequently, strategic naps are considered an efficacious means of maintaining performance while also reducing the individual's sleep debt. These types of naps have been advocated for pilots in particular, as opportunities to sleep either in the designated rest facilities or on the flight deck may be beneficial in reducing both the performance and alertness impairments associated with fatigue, as well as the subjective feelings of sleepiness. Evidence suggests that strategic naps can reduce subjective feelings of fatigue and improve performance and alertness. Despite some contraindications to implementing strategic naps while on duty, such as sleep inertia experienced upon awakening, both researchers and pilots agree that the benefits associated with these naps far outweigh the potential risks. This article is a literature review detailing both the health and safety concerns of fatigue among commercial pilots as well as benefits and risks associated with strategic napping to alleviate this fatigue. PMID:24215936

  7. Rapid-Eye-Movement-Sleep (REM) Associated Enhancement of Working Memory Performance after a Daytime Nap.

    PubMed

    Lau, Esther Yuet Ying; Wong, Mark Lawrence; Lau, Kristy Nga Ting; Hui, Florence Wai Ying; Tseng, Chia-huei

    2015-01-01

    The main objective was to study the impact of a daytime sleep opportunity on working memory and the mechanism behind such impact. This study adopted an experimental design in a sleep research laboratory. Eighty healthy college students (Age:17-23, 36 males) were randomized to either have a polysomnography-monitored daytime sleep opportunity (Nap-group, n=40) or stay awake (Wake-group, n=40) between the two assessment sessions. All participants completed a sleep diary and wore an actigraph-watch for 5 days before and one day after the assessment sessions. They completed the state-measurement of sleepiness and affect, in addition to a psychomotor vigilance test and a working memory task before and after the nap/wake sessions. The two groups did not differ in their sleep characteristics prior to and after the lab visit. The Nap-group had higher accuracy on the working memory task, fewer lapses on the psychomotor vigilance test and lower state-sleepiness than the Wake-group. Within the Nap-group, working memory accuracy was positively correlated with duration of rapid eye movement sleep (REM) and total sleep time during the nap. Our findings suggested that "sleep gain" during a daytime sleep opportunity had significant positive impact on working memory performance, without affecting subsequent nighttime sleep in young adult, and such impact was associated with the duration of REM. While REM abnormality has long been noted in pathological conditions (e.g. depression), which are also presented with cognitive dysfunctions (e.g. working memory deficits), this was the first evidence showing working memory enhancement associated with REM in daytime napping in college students, who likely had habitual short sleep duration but were otherwise generally healthy. PMID:25970511

  8. Toddler's self-regulation strategies in a challenge context are nap-dependent.

    PubMed

    Miller, Alison L; Seifer, Ronald; Crossin, Rebecca; Lebourgeois, Monique K

    2015-06-01

    Early childhood represents a time of developmental changes in both sleep and self-regulation, a construct reflecting the ability to control one's behaviour, attention and emotions when challenged. Links between sleep and self-regulation processes have been proposed, but experimental evidence with young children is lacking. In the current study, we tested the effects of acute sleep restriction (nap deprivation) on toddlers' self-regulation. Healthy children (n = 12; four males; aged 30-36 months (33.9 ± 1.7)) slept on a strict schedule (verified with actigraphy and sleep diaries) for 5 days before each of two afternoon assessments following a nap and a no-nap condition (~11-day protocol). Children were videotaped while attempting an unsolvable puzzle, and 10 mutually exclusive self-regulation strategies were later coded. On average, children lost ~90 min of sleep on the no-nap versus the nap day. Nap deprivation resulted in moderate-to-large effects on self-regulation strategies, with decreases in scepticism (d = 0.77; 7% change), negative self-appraisal (d = 0.92; 5% change) and increases in physical self-soothing (d = 0.68; 10% change), focus on the puzzle piece that would not fit (perseveration; d = 0.50; 9% change) and insistence on completing the unsolvable puzzle (d = 0.91; 10% change). Results suggest that sleep serves an important role in the way that toddlers respond to challenging events in their daily lives. After losing daytime sleep, toddlers were less able to engage effectively in a difficult task and reverted to less mature self-regulation strategies than when they were well rested. Over time, chronically missed sleep may impair young children's self-regulation abilities, resulting in risk for social-emotional, behavioural and school problems. PMID:25394169

  9. Structural evidence for Nap1-dependent H2A-H2B deposition and nucleosome assembly.

    PubMed

    Aguilar-Gurrieri, Carmen; Larabi, Amédé; Vinayachandran, Vinesh; Patel, Nisha A; Yen, Kuangyu; Reja, Rohit; Ebong, Ima-O; Schoehn, Guy; Robinson, Carol V; Pugh, B Franklin; Panne, Daniel

    2016-07-01

    Nap1 is a histone chaperone involved in the nuclear import of H2A-H2B and nucleosome assembly. Here, we report the crystal structure of Nap1 bound to H2A-H2B together with in vitro and in vivo functional studies that elucidate the principles underlying Nap1-mediated H2A-H2B chaperoning and nucleosome assembly. A Nap1 dimer provides an acidic binding surface and asymmetrically engages a single H2A-H2B heterodimer. Oligomerization of the Nap1-H2A-H2B complex results in burial of surfaces required for deposition of H2A-H2B into nucleosomes. Chromatin immunoprecipitation-exonuclease (ChIP-exo) analysis shows that Nap1 is required for H2A-H2B deposition across the genome. Mutants that interfere with Nap1 oligomerization exhibit severe nucleosome assembly defects showing that oligomerization is essential for the chaperone function. These findings establish the molecular basis for Nap1-mediated H2A-H2B deposition and nucleosome assembly. PMID:27225933

  10. FlyNap (Triethylamine) Increases the Heart Rate of Mosquitoes and Eliminates the Cardioacceleratory Effect of the Neuropeptide CCAP

    PubMed Central

    Chen, Weihan; Hillyer, Julián F.

    2013-01-01

    FlyNap (triethylamine) is commonly used to anesthetize Drosophila melanogaster fruit flies. The purpose of this study was to determine whether triethylamine is a suitable anesthetic agent for research into circulatory physiology and immune competence in the mosquito, Anopheles gambiae (Diptera: Culicidae). Recovery experiments showed that mosquitoes awaken from traditional cold anesthesia in less than 7 minutes, but that recovery from FlyNap anesthesia does not begin for several hours. Relative to cold anesthesia, moderate exposures to FlyNap induce an increase in the heart rate, a decrease in the percentage of the time the heart contracts in the anterograde direction, and a decrease in the frequency of heartbeat directional reversals. Experiments employing various combinations of cold and FlyNap anesthesia then showed that cold exposure does not affect basal heart physiology, and that the differences seen between the cold and the FlyNap groups are due to a FlyNap-induced alteration of heart physiology. Furthermore, exposure to FlyNap eliminated the cardioacceleratory effect of crustacean cardioactive peptide (CCAP), and reduced a mosquito’s ability to survive a bacterial infection. Together, these data show that FlyNap is not a suitable substitute to cold anesthesia in experiments assessing mosquito heart function or immune competence. Moreover, these data also illustrate the intricate biology of the insect heart. Specifically, they confirm that the neurohormone CCAP modulates heart rhythms and that it serves as an anterograde pacemaker. PMID:23875027

  11. KSHV encoded LANA recruits Nucleosome Assembly Protein NAP1L1 for regulating viral DNA replication and transcription

    PubMed Central

    Gupta, Namrata; Thakker, Suhani; Verma, Subhash C.

    2016-01-01

    The establishment of latency is an essential for lifelong persistence and pathogenesis of Kaposi’s sarcoma-associated herpesvirus (KSHV). Latency-associated nuclear antigen (LANA) is the most abundantly expressed protein during latency and is important for viral genome replication and transcription. Replication-coupled nucleosome assembly is a major step in packaging the newly synthesized DNA into chromatin, but the mechanism of KSHV genome chromatinization post-replication is not understood. Here, we show that nucleosome assembly protein 1-like protein 1 (NAP1L1) associates with LANA. Our binding assays revealed an association of LANA with NAP1L1 in KSHV-infected cells, which binds through its amino terminal domain. Association of these proteins confirmed their localization in specific nuclear compartments of the infected cells. Chromatin immunoprecipitation assays from NAP1L1-depleted cells showed LANA-mediated recruitment of NAP1L1 at the terminal repeat (TR) region of the viral genome. Presence of NAP1L1 stimulated LANA-mediated DNA replication and persistence of a TR-containing plasmid. Depletion of NAP1L1 led to a reduced nucleosome positioning on the viral genome. Furthermore, depletion of NAP1L1 increased the transcription of viral lytic genes and overexpression decreased the promoter activities of LANA-regulated genes. These results confirmed that LANA recruitment of NAP1L1 helps in assembling nucleosome for the chromatinization of newly synthesized viral DNA. PMID:27599637

  12. A Brief Nap Is Beneficial for Human Route-Learning: The Role of Navigation Experience and EEG Spectral Power

    ERIC Educational Resources Information Center

    Wamsley, Erin J.; Tucker, Matthew A.; Payne, Jessica D.; Stickgold, Robert

    2010-01-01

    Here, we examined the effect of a daytime nap on changes in virtual maze performance across a single day. Participants either took a short nap or remained awake following training on a virtual maze task. Post-training sleep provided a clear performance benefit at later retest, but only for those participants with prior experience navigating in a…

  13. KSHV encoded LANA recruits Nucleosome Assembly Protein NAP1L1 for regulating viral DNA replication and transcription.

    PubMed

    Gupta, Namrata; Thakker, Suhani; Verma, Subhash C

    2016-01-01

    The establishment of latency is an essential for lifelong persistence and pathogenesis of Kaposi's sarcoma-associated herpesvirus (KSHV). Latency-associated nuclear antigen (LANA) is the most abundantly expressed protein during latency and is important for viral genome replication and transcription. Replication-coupled nucleosome assembly is a major step in packaging the newly synthesized DNA into chromatin, but the mechanism of KSHV genome chromatinization post-replication is not understood. Here, we show that nucleosome assembly protein 1-like protein 1 (NAP1L1) associates with LANA. Our binding assays revealed an association of LANA with NAP1L1 in KSHV-infected cells, which binds through its amino terminal domain. Association of these proteins confirmed their localization in specific nuclear compartments of the infected cells. Chromatin immunoprecipitation assays from NAP1L1-depleted cells showed LANA-mediated recruitment of NAP1L1 at the terminal repeat (TR) region of the viral genome. Presence of NAP1L1 stimulated LANA-mediated DNA replication and persistence of a TR-containing plasmid. Depletion of NAP1L1 led to a reduced nucleosome positioning on the viral genome. Furthermore, depletion of NAP1L1 increased the transcription of viral lytic genes and overexpression decreased the promoter activities of LANA-regulated genes. These results confirmed that LANA recruitment of NAP1L1 helps in assembling nucleosome for the chromatinization of newly synthesized viral DNA. PMID:27599637

  14. The Effects of a Nighttime Nap on the Error-Monitoring Functions During Extended Wakefulness

    PubMed Central

    Asaoka, Shoichi; Fukuda, Kazuhiko; Murphy, Timothy I.; Abe, Takashi; Inoue, Yuichi

    2012-01-01

    Study Objectives: To examine the effects of a 1-hr nighttime nap, and the associated sleep inertia, on the error-monitoring functions during extended wakefulness using the 2 event-related potential components thought to reflect error detection and emotional or motivational evaluation of the error, i.e., the error-related negativity/error-negativity (ERN/Ne) and error-positivity (Pe), respectively. Design: Participants awakened at 07:00 the morning of the experimental day, and performed a stimulus-response compatibility (arrow-orientation) task at 21:00, 02:00, and 03:00. Setting: A cognitive task with EEG data recording was performed in a laboratory setting. Participants: Twenty young adults (mean age 21.3 ± 1.0 yr, 14 males) participated. Interventions: Half of the participants took a 1-hr nap, and the others had a 1-hr awake-rest period from 01:00-02:00. Measurements and Results: Behavioral performance and amplitude of the Pe declined after midnight (i.e., 02:00 and 03:00) compared with the 21:00 task period in both groups. During the task period starting at 03:00, the participants in the awake-rest condition reported less alertness and showed fewer correct responses than those who napped. However, there were no effects of a nap on the amplitude of the ERN/Ne or Pe. Conclusions: Our results suggest that a 1-hr nap can alleviate the decline in subjective alertness and response accuracy during nighttime; however, error-monitoring functions, especially emotional or motivational evaluation of the error, might remain impaired by extended wakefulness even after the nap. This phenomenon could imply that night-shift workers experiencing extended wakefulness should not overestimate the positive effects of a nighttime 1-hr nap during extended wakefulness. Citation: Asaoka S; Fukuda K; Murphy TI; Abe T; Inoue Y. The effects of a nighttime nap on the error-monitoring functions during extended wakefulness. SLEEP 2012;35(6):871-878. PMID:22654206

  15. Afternoon Nap and Bright Light Exposure Improve Cognitive Flexibility Post Lunch

    PubMed Central

    Schmitz, Rémy; Peigneux, Philippe; Leproult, Rachel

    2015-01-01

    Beneficial effects of napping or bright light exposure on cognitive performance have been reported in participants exposed to sleep loss. Nonetheless, few studies investigated the effect of these potential countermeasures against the temporary drop in performance observed in mid-afternoon, and even less so on cognitive flexibility, a crucial component of executive functions. This study investigated the impact of either an afternoon nap or bright light exposure on post-prandial alterations in task switching performance in well-rested participants. Twenty-five healthy adults participated in two randomized experimental conditions, either wake versus nap (n=15), or bright light versus placebo (n=10). Participants were tested on a switching task three times (morning, post-lunch and late afternoon sessions). The interventions occurred prior to the post-lunch session. In the nap/wake condition, participants either stayed awake watching a 30-minute documentary or had the opportunity to take a nap for 30 minutes. In the bright light/placebo condition, participants watched a documentary under either bright blue light or dim orange light (placebo) for 30 minutes. The switch cost estimates cognitive flexibility and measures task-switching efficiency. Increased switch cost scores indicate higher difficulties to switch between tasks. In both control conditions (wake or placebo), accuracy switch-cost score increased post lunch. Both interventions (nap or bright light) elicited a decrease in accuracy switch-cost score post lunch, which was associated with diminished fatigue and decreased variability in vigilance. Additionally, there was a trend for a post-lunch benefit of bright light with a decreased latency switch-cost score. In the nap group, improvements in accuracy switch-cost score were associated with more NREM sleep stage N1. Thus, exposure to bright light during the post-lunch dip, a countermeasure easily applicable in daily life, results in similar beneficial effects as

  16. Physical Fitness of Police Academy Cadets: Baseline Characteristics and Changes During a 16-Week Academy.

    PubMed

    Crawley, Amy A; Sherman, Ross A; Crawley, William R; Cosio-Lima, Ludmila M

    2016-05-01

    Police academies traditionally emphasize the importance of being physically fit. The purpose of this research was to determine cadet baseline physical fitness characteristics and assess effectiveness of a 16-week training program. Sixty-eight cadets (61 men, 7 women) volunteered to have baseline physical fitness characteristics assessed, and 55 cadets (49 men, 6 women) completed further testing at weeks 8 and 16. The testing comprised hand grip (strength), arm crank (upper-body power), 30 seconds Wingate (lower body power), sum of skinfolds and percentage body fat (body composition), 40-yard dash (sprint speed), 1 repetition maximum bench press (strength), T-test (agility), and sit-and-reach (flexibility). In addition, cadets completed standardized state testing (push-ups, sit-ups, vertical jump, and half-mile shuttle run). The training program consisted of 1 hour sessions, 3 d·wk, including aerobic, plyometrics, body weight, and resistance exercise. Significant changes were found in agility (p < 0.01), upper-body and lower-body peak power (p ≤ 0.05), sit-ups (p < 0.01), push-ups (p ≤ 0.05) across the first 8 weeks, and in agility (p ≤ 0.05), lower-body peak power (p ≤ 0.05), sit-ups (p < 0.01), push-ups (p ≤ 0.05), half-mile shuttle run (p < 0.01) across the full 16 weeks. However, none of the variables showed significant change across the second half of the program (weeks 8-16). A number of individual parameters of physical fitness showed evidence of improvement in the first 8 weeks, whereas none of the variables showed significant improvement in the second 8 weeks. This suggests modifications could be made to increase overall effectiveness of cadet physical training specifically after the 8-week mark. PMID:26466133

  17. A NAP-AAO3 Regulatory Module Promotes Chlorophyll Degradation via ABA Biosynthesis in Arabidopsis Leaves[W][OPEN

    PubMed Central

    Yang, Jiading; Worley, Eric

    2014-01-01

    Chlorophyll degradation is an important part of leaf senescence, but the underlying regulatory mechanisms are largely unknown. Excised leaves of an Arabidopsis thaliana NAC-LIKE, ACTIVATED BY AP3/PI (NAP) transcription factor mutant (nap) exhibited lower transcript levels of known chlorophyll degradation genes, STAY-GREEN1 (SGR1), NON-YELLOW COLORING1 (NYC1), PHEOPHYTINASE (PPH), and PHEIDE a OXYGENASE (PaO), and higher chlorophyll retention than the wild type during dark-induced senescence. Transcriptome coexpression analysis revealed that abscisic acid (ABA) metabolism/signaling genes were disproportionately represented among those positively correlated with NAP expression. ABA levels were abnormally low in nap leaves during extended darkness. The ABA biosynthetic genes 9-CIS-EPOXYCAROTENOID DIOXYGENASE2, ABA DEFICIENT3, and ABSCISIC ALDEHYDE OXIDASE3 (AAO3) exhibited abnormally low transcript levels in dark-treated nap leaves. NAP transactivated the promoter of AAO3 in mesophyll cell protoplasts, and electrophoretic mobility shift assays showed that NAP can bind directly to a segment (−196 to −162 relative to the ATG start codon) of the AAO3 promoter. Exogenous application of ABA increased the transcript levels of SGR1, NYC1, PPH, and PaO and suppressed the stay-green phenotype of nap leaves during extended darkness. Overexpression of AAO3 in nap leaves also suppressed the stay-green phenotype under extended darkness. Collectively, the results show that NAP promotes chlorophyll degradation by enhancing transcription of AAO3, which leads to increased levels of the senescence-inducing hormone ABA. PMID:25516602

  18. Four Theories of the Press.

    ERIC Educational Resources Information Center

    Siebert, Fred S.; And Others

    A systematic understanding of the press requires an understanding of the social and political structures within which the press operates. This book discusses four theories that have determined the kind of press the Western world has had: authoritarian, libertarian, socially responsible, and Soviet communist. Each chapter discusses press…

  19. 77 FR 48506 - CPSC Safety Academy

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-14

    ... products, the mandatory toy standard, and compliance issues. The CPSC Safety Academy will be held on...: ``F963 Toy Standards''; ``Testing-Mandatory Testing, Component Parts Testing, Certificates of...

  20. Einstein Session of the Pontifical Academy.

    ERIC Educational Resources Information Center

    Science, 1980

    1980-01-01

    The texts of four speeches, given at the 1979 Einstein Session of the Pontifical Academy held in Rome, are presented. Each address relates to some aspect of the life and times of Albert Einstein. (SA)

  1. CAI in Thermodynamics at the USAF Academy.

    ERIC Educational Resources Information Center

    Byerley, Aaron R.; Winn, Robert C.

    1986-01-01

    Illustrates computer assisted instruction (CAI) at the United States Air Force (USAF) academy by presenting a sample CAI session involving thermodynamics. Comments on evaluation of the program. Future plans are included. (JN)

  2. The USAF Academy Basic Physics Exam File.

    ERIC Educational Resources Information Center

    Enger, Rolf C.

    1981-01-01

    Describes the purpose, construction, use, maintenance, and improvement of a basic physics examination file by the U.S. Air Force Academy. Includes nine sample objectives, two multiple-choice items, and an example of computer item analysis. (SK)

  3. French academy cries out over swingeing cuts

    NASA Astrophysics Data System (ADS)

    Dumé, Belle

    2014-02-01

    The French Academy of Sciences has issued what it calls a "cry of alarm" denouncing heavy cuts to the 2014 budget for the National Research Agency (ANR), which was set up in 2005 to fund project-based research.

  4. American Academy of Allergy, Asthma, and Immunology

    MedlinePlus

    ... learn about cutting-edge research and enrich your networking connections. Learn More about the American Academy Of ... Rights Reserved. Legal Notices | Site Map | Contact Us Social navigation Facebook Twitter Mobile navigation Home Conditions & Treatments ...

  5. Fracture of the Scaphoid During a Bench-Press Exercise.

    PubMed

    Mason, John S; Crowell, Michael S; Goss, Donald L

    2015-08-01

    The patient was a 21-year-old male cadet at a military academy who was evaluated by a physical therapist in a direct-access capacity for a chief complaint of left wrist pain that began 1 day after injuring his wrist while performing a bench-press exercise. Due to concern for a scaphoid fracture and because radiographic imaging was not immediately available, a physical therapist credentialed to utilize fluoroscopy evaluated the left wrist. Radiographs were subsequently ordered, which confirmed a mid-waist, nondisplaced scaphoid fracture. PMID:26232322

  6. The Bulgarian Academy of Sciences in Transition from Learned Society to Totalitarian Academy (1944 1949)

    NASA Astrophysics Data System (ADS)

    Vavrek, Alexander

    The process of transforming the Bulgarian Academy of Sciences and Arts, founded in 1869 as a Bulgarian Learned Society, into a national research center began in 1940 and was significantly accelerated in 1944, immediately after the coup d''état of September 9, 1944, called during the last 50 years a ''socialist revolution''. Strong pressure was exerted on the Bulgarian ''bourgeois intelligentsia'' by the new Fatherland Front ruling circles controlled by the communists. Closing down of the old and appointing a new ''progressive'' Academy was also discussed. The urgent actions of the Executive Council of the Academy prevented these plans. A number of progressive-minded scholars and artists were elected to the Bulgarian Academy of Sciences and Arts in January 1945 and July 1946, and a plan for reorganizing the Academy was approved in November 1945. This opening stage of self-restructuring of the Academy was crossed out by the Law of the Bulgarian Academy of Sciences of 1947. By this law the Academy was transformed into a governmental organization, but some academic autonomy and respect for the academic traditions were preserved. Only two and a half years later, however, when the Bulgarian Communist Party had an absolute majority in the Parliament and the ''open building of socialism in the People''s Republic of Bulgaria'' had been already announced, a new, completely totalitarian, Law on the Bulgarian Academy of Sciences was passed.

  7. Differential Immunodetection of Toxin B from Highly Virulent Clostridium difficile BI/NAP-1/027

    PubMed Central

    Song, Linan; Zhao, Mingwei; Duffy, David C.; Chen, Xinhua; Sambol, Susan P.; Gerding, Dale N.; Kelly, Ciarán P.

    2015-01-01

    We developed a simple immunoassay capable of differentially detecting toxin B from highly virulent strains of Clostridium difficile (BI/NAP-1/027) in stool. This assay can simultaneously confirm the presence of in vivo toxin production and provide strain-related information relevant to infection control epidemiology and disease prognosis. PMID:25716449

  8. The Effects of Morning Naps, Car Trips, and Maternal Separation on Adrenocortical Activity in Human Infants.

    ERIC Educational Resources Information Center

    Larson, Mary C.; And Others

    1991-01-01

    Three studies examined adrenocortical activity in infants. Morning naps were associated with decreases in salivary cortisol. Riding for 40 minutes in a car lowered salivary cortisol concentrations. Thirty minutes of maternal separation in the laboratory resulted in higher salivary cortisol concentrations than did 30 minutes of play with the mother…

  9. Deep-sea hydrothermal vent Epsilonproteobacteria encode a conserved and widespread nitrate reduction pathway (Nap)

    PubMed Central

    Vetriani, Costantino; Voordeckers, James W; Crespo-Medina, Melitza; O'Brien, Charles E; Giovannelli, Donato; Lutz, Richard A

    2014-01-01

    Despite the frequent isolation of nitrate-respiring Epsilonproteobacteria from deep-sea hydrothermal vents, the genes coding for the nitrate reduction pathway in these organisms have not been investigated in depth. In this study we have shown that the gene cluster coding for the periplasmic nitrate reductase complex (nap) is highly conserved in chemolithoautotrophic, nitrate-reducing Epsilonproteobacteria from deep-sea hydrothermal vents. Furthermore, we have shown that the napA gene is expressed in pure cultures of vent Epsilonproteobacteria and it is highly conserved in microbial communities collected from deep-sea vents characterized by different temperature and redox regimes. The diversity of nitrate-reducing Epsilonproteobacteria was found to be higher in moderate temperature, diffuse flow vents than in high temperature black smokers or in low temperatures, substrate-associated communities. As NapA has a high affinity for nitrate compared with the membrane-bound enzyme, its occurrence in vent Epsilonproteobacteria may represent an adaptation of these organisms to the low nitrate concentrations typically found in vent fluids. Taken together, our findings indicate that nitrate reduction is widespread in vent Epsilonproteobacteria and provide insight on alternative energy metabolism in vent microorganisms. The occurrence of the nap cluster in vent, commensal and pathogenic Epsilonproteobacteria suggests that the ability of these bacteria to respire nitrate is important in habitats as different as the deep-sea vents and the human body. PMID:24430487

  10. 32 CFR 575.6 - Catalogue, United States Military Academy.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 3 2012-07-01 2009-07-01 true Catalogue, United States Military Academy. 575.6... ADMISSION TO THE UNITED STATES MILITARY ACADEMY § 575.6 Catalogue, United States Military Academy. The latest edition of the catalogue, United States Military Academy, contains additional...

  11. 32 CFR 575.6 - Catalogue, United States Military Academy.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 3 2013-07-01 2013-07-01 false Catalogue, United States Military Academy. 575.6... ADMISSION TO THE UNITED STATES MILITARY ACADEMY § 575.6 Catalogue, United States Military Academy. The latest edition of the catalogue, United States Military Academy, contains additional...

  12. 32 CFR 575.6 - Catalogue, United States Military Academy.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 3 2014-07-01 2014-07-01 false Catalogue, United States Military Academy. 575.6... ADMISSION TO THE UNITED STATES MILITARY ACADEMY § 575.6 Catalogue, United States Military Academy. The latest edition of the catalogue, United States Military Academy, contains additional...

  13. 32 CFR 575.6 - Catalogue, United States Military Academy.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 3 2010-07-01 2010-07-01 true Catalogue, United States Military Academy. 575.6... ADMISSION TO THE UNITED STATES MILITARY ACADEMY § 575.6 Catalogue, United States Military Academy. The latest edition of the catalogue, United States Military Academy, contains additional...

  14. 32 CFR 575.6 - Catalogue, United States Military Academy.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 3 2011-07-01 2009-07-01 true Catalogue, United States Military Academy. 575.6... ADMISSION TO THE UNITED STATES MILITARY ACADEMY § 575.6 Catalogue, United States Military Academy. The latest edition of the catalogue, United States Military Academy, contains additional...

  15. Clostridium difficile infection caused by the epidemic BI/NAP1/027 strain.

    PubMed

    O'Connor, Jennifer R; Johnson, Stuart; Gerding, Dale N

    2009-05-01

    Rates and severity of Clostridium difficile infection (CDI) in hospitals in North America and Europe have increased since 2000 and correlate with dissemination of an epidemic strain characterized by higher than usual toxin A and B production, the presence of a third toxin, binary toxin, and high-level resistance to fluoroquinolone antibiotics. The strain, which is restriction endonuclease analysis group BI, pulse-field gel electrophoresis type NAP1, and polymerase chain reaction ribotype 027, is designated BI/NAP1/027. How this strain has become so widely distributed geographically and produces such severe CDI is the subject of active investigation. The deletion at position 117 of the tcdC gene, a repressor of toxin A and B production, is one possible contributor to increased levels of the toxins. The role of binary toxin is unknown. Recent isolates of BI/NAP1/027 were found to be resistant to fluoroquinolones, which is likely to contribute to the dissemination of this strain. Other virulence factors such as increased sporulation and surface layer protein adherence are also under investigation. Infections caused by this organism are particularly frequent among elderly hospitalized patients, in whom the attributable 30-day mortality is greater than 5%. Major risk factors for BI/NAP1/027 infection include advanced age, hospitalization, and exposure to specific antimicrobials, especially fluoroquinolones and cephalosporins. When CDI is severe, vancomycin treatment is more effective than metronidazole; for mild disease either agent can be used. Control of hospital outbreaks caused by BI/NAP1/027 is difficult but possible through a combination of barrier precautions, environmental cleaning, and antimicrobial stewardship. PMID:19457419

  16. Novel tubulin and tau neuroprotective fragments sharing structural similarities with the drug candidate NAP (Davuentide).

    PubMed

    Gozes, Illana; Iram, Tal; Maryanovsky, Evgenia; Arviv, Carmit; Rozenberg, Liora; Schirer, Yulie; Giladi, Eliezer; Furman-Assaf, Sharon

    2014-01-01

    NAP (NAPVSIPQ, davunetide) is a microtubule stabilizing peptide drug candidate. Here, we set out to identify NAP-like peptides that provide neuroprotection and reduce tau pathology. NAP-like peptides were derived using publically available search engines, which identified sequence homologies in the microtubule subunit tubulin and in the microtubule associated protein, tau. NATLSIHQ (NAT) and STPTAIPQ were derived from tubulin, and TAPVPMPD (TAP) was derived from tau. All peptides provided neuroprotection against the Alzheimer's disease (AD) toxin, the amyloid-β 1-42 peptide, although NAT and TAP were much more potent than STPTAIPQ. NAT also protected astrocytes, while STPTAIPQ was active only at micromolar concentrations. Because NAT and TAP were much more potent than STPTAIPQ in neuroprotection, those peptides were also tested for inhibition of tau-like aggregation (the second protein hallmark pathology of AD). Both NAT and TAP inhibited tau-like aggregation, with NAT being active over a very broad concentration range. NAT also protected in vivo in a frontotemporal dementia transgenic mouse model (Tau-Tg), when tested at the age of ~10 months. Results showed significantly decreased levels of the NAP parent protein, activity-dependent neuroprotective protein in the cerebral cortex of the Tau-Tg which was increased back to normal levels by NAT treatment. This was coupled to protection of Brain-Body weight ratio in the compromised Tau-Tg. With AD being the major tauopathy and with tau taking part in frontotemporal dementia, novel NAP derivatives that reduce tauopathy and provide neuroprotection are of basic and clinical interest. PMID:24503616

  17. Control of periplasmic nitrate reductase gene expression (napEDABC) from Paracoccus pantotrophus in response to oxygen and carbon substrates.

    PubMed

    Sears, H J; Sawers, G; Berks, B C; Ferguson, S J; Richardson, D J

    2000-11-01

    The napEDABC operon of Paracoccus pantotrophus encodes a periplasmic nitrate reductase (NAP), together with electron-transfer components and proteins required for the synthesis of a fully functional enzyme. Previously, it had been shown that high NAP activity was observed when P. pantotrophus was grown aerobically on highly reduced carbon sources such as butyrate or caproate, but not when cultured on more oxidized substrates such as succinate or malate. The enzyme is not present to any extent when the organism is grown anaerobically under denitrifying conditions, regardless of the carbon source. Transcriptional analyses of the nap operon have now identified two initiation sites which were differentially regulated in response to the carbon source, with expression being maximal when cells were grown aerobically with butyrate. Analysis of a P. pantotrophus mutant (M6) deregulated for NAP activity identified a single C-->A transversion in a heptameric inverted-repeat sequence that partially overlapped the proximal promoter. Transcription analysis of this mutant revealed that expression of nap was completely derepressed under all growth conditions examined. Taken together, these findings indicate that nap transcription is negatively regulated during anaerobiosis, such that expression is restricted to aerobic growth, but only when the carbon source is highly reduced. PMID:11065376

  18. Napping in older people 'at risk' of dementia: relationships with depression, cognition, medical burden and sleep quality.

    PubMed

    Cross, Nathan; Terpening, Zoe; Rogers, Naomi L; Duffy, Shantel L; Hickie, Ian B; Lewis, Simon J G; Naismith, Sharon L

    2015-10-01

    Sleep disturbance is prevalent in older adults, particularly so in those at a greater risk of dementia. However, so far the clinical, medical and neuropsychological correlates of daytime sleep have not been examined. The aims of this study were to investigate the characteristics and effects of napping using actigraphy in older people, particularly in those 'at risk' of dementia. The study used actigraphy and sleep diaries to measure napping habits in 133 older adults 'at risk' of dementia (mean age = 65.5 years, SD = 8.4 years), who also underwent comprehensive medical, psychiatric and neuropsychological assessment. When defined by actigraphy, napping was present in 83.5% (111/133) of participants; however, duration and timing varied significantly among subjects. Nappers had significantly greater medical burden and body mass index, and higher rates of mild cognitive impairment. Longer and more frequent naps were associated with poorer cognitive functioning, as well as higher levels of depressive symptoms, while the timing of naps was associated with poorer nocturnal sleep quality (i.e. sleep latency and wake after sleep onset). This study highlights that in older adults 'at risk' of dementia, napping is associated with underlying neurobiological changes such as depression and cognition. Napping characteristics should be more routinely monitored in older individuals to elucidate their relationship with psychological and cognitive outcomes. PMID:26096839

  19. The UCSF Academy of Medical Educators.

    PubMed

    Cooke, Molly; Irby, David M; Debas, Haile T

    2003-07-01

    The Academy of Medical Educators at the University of California, San Francisco (UCSF), was established in 2000 to (1) foster excellence in teaching, (2) support teachers of medicine, and (3) promote curricular innovation. A membership organization, it recognizes five categories of educational activity: direct teaching, curriculum development and assessment of learner performance, advising and mentoring, educational administration and leadership, and educational research. Excellent medical student teaching and outstanding accomplishment in one or more areas of educational activity qualify a teacher for membership. Candidates prepare a portfolio that is reviewed internally and by national experts in medical education. Currently 37 faculty members, 3% of the entire school of medicine faculty, belong to the academy. The academy's innovations funding program disburses one-year grants to support curricular development and comparisons of pedagogical approaches; through this mechanism, the academy has funded 20 projects at a total cost of $442,300. Three fourths of expended funds support faculty release time. Faculty development efforts include promotion of the use of an educator's portfolio and the establishment of a mentoring program for junior faculty members built around observation of teaching. The Academy of Medical Educators vigorously supports expanded scholarship in education; the academy-sponsored Education Day is an opportunity for educators to present their work locally. Recipients of innovations-funding program grants are expected to present their work in an appropriate national forum and are assisted in doing this through quarterly scholarship clinics. The Academy of Medical Educators has been well received at UCSF and is enhancing the status of medical education and teachers. PMID:12857682

  20. National Academies-Review of the Research Program of the FreedomCAR and Fuel Partnership. Third Report

    SciTech Connect

    none,

    2011-06-09

    This report by the National Research Council's (NRC's) Committee on Review of the FreedomCAR and Fuel Research Program, Phase 3, is the third NRC review. The Phase 1 and Phase 2 reviews were issued in 2005 and 2008, respectively (NRC, 2005, 2008). The long-range goals of the Partnership focus on a transition to a highway transportation system that uses sustainable energy resources and reduces emissions, including net carbon emissions, on a life-cycle or well (source)-to-wheels basis (DOE, 2004). The Partnership focuses on precompetitive research and development (R&D) that can help to accelerate the emergence of technologies that can meet the long-range goals. • This review document is published by National Academies Press. You may (a) read the text for free on the National Academies Press web site, (b) download a free PDF after providing some identifying information, or (c) purchase a paperback copy of the book.

  1. 75 FR 52318 - Presidential Academies for American History and Civics Education; Congressional Academies for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-25

    ... period in the Federal Register on June 30, 2010, (75 FR 37780). That notice contained background... Presidential Academies for American History and Civics Education; Congressional Academies for Students of American History and Civics Education AGENCY: Office of Innovation and Improvement, Department of...

  2. CIDER PRESS, LOOKING SOUTHEAST ACROSS THE SCHUYLKILL RIVER. THIS PRESS, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    CIDER PRESS, LOOKING SOUTHEAST ACROSS THE SCHUYLKILL RIVER. THIS PRESS, CARVED OUT OF A LARGE BOULDER AT THE RIVERS EDGE, PROBABLY DATES FROM THE LIFETIME OF JOHN BARTRAM, IF NOT TO THE SWEDISH SETTLERS BEFORE HIM. THE IRON FENCE IS A NINETEENTH-CENTURY ADDITION - John Bartram House & Garden, 54th Street & Lindbergh Boulevard, Philadelphia, Philadelphia County, PA

  3. PRESS SHOP. SEVEN BLISS PRESSES STAMP OUT A VARIETY OF ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    PRESS SHOP. SEVEN BLISS PRESSES STAMP OUT A VARIETY OF CARTRIDGE AND SHELL CASINGS. THIS DEPARTMENT WAS TRANSFORMED FROM A MONEY-LOSING OPERATION TO A PROFIT CENTER UNDER THE FIRST WORKER-MANAGED QUALITY CIRCLE IN THE PLANT. - American Brass Foundry, 70 Sayre Street, Buffalo, Erie County, NY

  4. Integrating nap and night-time sleep into sleep patterns reveals differential links to health-relevant outcomes.

    PubMed

    Devine, Jaime K; Wolf, Jutta M

    2016-04-01

    Both night-time sleep and nap behaviour have been linked consistently to health outcomes. Although reasons for napping are usually tied to night-time sleep, the majority of studies assess their effects independently. The current study thus aimed to examine the health relevance of patterns of sleep behaviour that take into account both night-time and daytime sleep habits. Night-time sleep, recorded during 7 days via actigraphy from 313 participants (aged 34-82 years) of the Midlife in the United States II Biomarker study, was assessed. Blood and urine specimens were assayed for noradrenaline, interleukin-6 and C-reactive protein. Participants self-reported nap behaviour, depressive symptoms, perceived chronic stress and the presence of medical symptoms and conditions. Overall, nappers (n = 208) showed elevated waist-hip ratios, C-reactive protein and interleukin-6 levels compared to non-nappers and reported more physiological symptoms and conditions (all P ≤ 0.019). Within nappers, cluster analysis revealed three patterns of sleep behaviour-infrequent nappers with good night-time sleep, frequent nappers with good night-time sleep and nappers with poor night-time sleep. Nappers with poor night-time sleep thereby exhibited elevated noradrenaline levels, depressive symptoms and perceived stress scores compared to other groups (all P ≤ 0.041). These findings support the idea that nap-health relationships are complex, in that frequency of napping and accumulation of nap sleep is not related linearly to health consequences. Assessing nap behaviour in conjunction with night-time sleep behaviour appeared crucial to elucidate further the health relevance of napping, particularly in terms of psychological health outcomes, including chronic stress and depressive symptoms. PMID:26718988

  5. NAP SACC: Implementation of an Obesity Prevention Intervention in an American Indian Head Start Program.

    PubMed

    Mattingly, Julie A; Andresen, Pamela A

    2016-01-01

    Low-income American Indian preschoolers are at greatest risk for overweight and obesity among children aged 2-5 years. The Nutrition and Physical Activity Self-Assessment for Child Care (NAP SACC) program is an evidence-based intervention that promotes healthy weight development for children enrolled in child care centers. The goal of this continuous quality improvement program is for the child care staff to establish environmental policies and practices that positively influence nutrition and physical activity-related behaviors. A community needs assessment of a Head Start program on an American Indian reservation identified obesity as a priority issue. This project implemented NAP SACC at 15 Head Start sites on the reservation. PMID:27383778

  6. NAP-2 Secreted by Human NK Cells Can Stimulate Mesenchymal Stem/Stromal Cell Recruitment

    PubMed Central

    Almeida, Catarina R.; Caires, Hugo R.; Vasconcelos, Daniela P.; Barbosa, Mário A.

    2016-01-01

    Summary Strategies for improved homing of mesenchymal stem cells (MSCs) to a place of injury are being sought and it has been shown that natural killer (NK) cells can stimulate MSC recruitment. Here, we studied the chemokines behind this recruitment. Assays were performed with bone marrow human MSCs and NK cells freshly isolated from healthy donor buffy coats. Supernatants from MSC-NK cell co-cultures can induce MSC recruitment but not to the same extent as when NK cells are present. Antibody arrays and ELISA assays confirmed that NK cells secrete RANTES (CCL5) and revealed that human NK cells secrete NAP-2 (CXCL7), a chemokine that can induce MSC migration. Inhibition with specific antagonists of CXCR2, a receptor that recognizes NAP-2, abolished NK cell-mediated MSC recruitment. This capacity of NK cells to produce chemokines that stimulate MSC recruitment points toward a role for this immune cell population in regulating tissue repair/regeneration. PMID:27052313

  7. Erotic subset for the Nencki Affective Picture System (NAPS ERO): cross-sexual comparison study

    PubMed Central

    Wierzba, Małgorzata; Riegel, Monika; Pucz, Anna; Leśniewska, Zuzanna; Dragan, Wojciech Ł.; Gola, Mateusz; Jednoróg, Katarzyna; Marchewka, Artur

    2015-01-01

    Research on the processing of sexual stimuli has proved that such material has high priority in human cognition. Yet, although sex differences in response to sexual stimuli were extensively discussed in the literature, sexual orientation was given relatively little consideration, and material suitable for relevant research is difficult to come by. With this in mind, we present a collection of 200 erotic images, accompanied by their self-report ratings of emotional valence and arousal by homo- and heterosexual males and females (n = 80, divided into four equal-sized subsamples). The collection complements the Nencki Affective Picture System (NAPS) and is intended to be used as stimulus material in experimental research. The erotic images are divided into five categories, depending on their content: opposite-sex couple (50), male couple (50), female couple (50), male (25) and female (25). Additional 100 control images from the NAPS depicting people in a non-erotic context were also used in the study. We showed that recipient sex and sexual orientation strongly influenced the evaluation of erotic content. Thus, comparisons of valence and arousal ratings in different subject groups will help researchers select stimuli set for the purpose of various experimental designs. To facilitate the use of the dataset, we provide an on-line tool, which allows the user to browse the images interactively and select proper stimuli on the basis of several parameters. The NAPS ERO image collection together with the data are available to the scientific community for non-commercial use at http://naps.nencki.gov.pl. PMID:26441715

  8. Erotic subset for the Nencki Affective Picture System (NAPS ERO): cross-sexual comparison study.

    PubMed

    Wierzba, Małgorzata; Riegel, Monika; Pucz, Anna; Leśniewska, Zuzanna; Dragan, Wojciech Ł; Gola, Mateusz; Jednoróg, Katarzyna; Marchewka, Artur

    2015-01-01

    Research on the processing of sexual stimuli has proved that such material has high priority in human cognition. Yet, although sex differences in response to sexual stimuli were extensively discussed in the literature, sexual orientation was given relatively little consideration, and material suitable for relevant research is difficult to come by. With this in mind, we present a collection of 200 erotic images, accompanied by their self-report ratings of emotional valence and arousal by homo- and heterosexual males and females (n = 80, divided into four equal-sized subsamples). The collection complements the Nencki Affective Picture System (NAPS) and is intended to be used as stimulus material in experimental research. The erotic images are divided into five categories, depending on their content: opposite-sex couple (50), male couple (50), female couple (50), male (25) and female (25). Additional 100 control images from the NAPS depicting people in a non-erotic context were also used in the study. We showed that recipient sex and sexual orientation strongly influenced the evaluation of erotic content. Thus, comparisons of valence and arousal ratings in different subject groups will help researchers select stimuli set for the purpose of various experimental designs. To facilitate the use of the dataset, we provide an on-line tool, which allows the user to browse the images interactively and select proper stimuli on the basis of several parameters. The NAPS ERO image collection together with the data are available to the scientific community for non-commercial use at http://naps.nencki.gov.pl. PMID:26441715

  9. The CIA and the Press.

    ERIC Educational Resources Information Center

    Carvalho, Bernardo A.

    The involvement of the Central Intelligence Agency (CIA) with both United States and foreign news media has been recorded in numerous publications. This report reviews the important aspects of the CIA-press relationships as they have appeared in print and discusses the implications of these relationsihps for the credibility of the press. Media…

  10. Press, Politics and Popular Government.

    ERIC Educational Resources Information Center

    Will, George F., Ed.

    A panel discussion on politics and the press was held at the convention of the American Political Science Association in September 1971. This volume contains an essay delivered at that panel on the various functions or activities of the press--adversary, surrogate, sovereign--and remarks of the three discussants. In addition, an essay especially…

  11. Napping to renew learning capacity: enhanced encoding after stimulation of sleep slow oscillations.

    PubMed

    Antonenko, Daria; Diekelmann, Susanne; Olsen, Cathrin; Born, Jan; Mölle, Matthias

    2013-04-01

    As well as consolidating memory, sleep has been proposed to serve a second important function for memory, i.e. to free capacities for the learning of new information during succeeding wakefulness. The slow wave activity (SWA) that is a hallmark of slow wave sleep could be involved in both functions. Here, we aimed to demonstrate a causative role for SWA in enhancing the capacity for encoding of information during subsequent wakefulness, using transcranial slow oscillation stimulation (tSOS) oscillating at 0.75 Hz to induce SWA in healthy humans during an afternoon nap. Encoding following the nap was tested for hippocampus-dependent declarative materials (pictures, word pairs, and word lists) and procedural skills (finger sequence tapping). As compared with a sham stimulation control condition, tSOS during the nap enhanced SWA and significantly improved subsequent encoding on all three declarative tasks (picture recognition, cued recall of word pairs, and free recall of word lists), whereas procedural finger sequence tapping skill was not affected. Our results indicate that sleep SWA enhances the capacity for encoding of declarative materials, possibly by down-scaling hippocampal synaptic networks that were potentiated towards saturation during the preceding period of wakefulness. PMID:23301831

  12. The impact of napping on memory for future-relevant stimuli: Prioritization among multiple salience cues.

    PubMed

    Bennion, Kelly A; Payne, Jessica D; Kensinger, Elizabeth A

    2016-06-01

    Prior research has demonstrated that sleep enhances memory for future-relevant information, including memory for information that is salient due to emotion, reward, or knowledge of a later memory test. Although sleep has been shown to prioritize information with any of these characteristics, the present study investigates the novel question of how sleep prioritizes information when multiple salience cues exist. Participants encoded scenes that were future-relevant based on emotion (emotional vs. neutral), reward (rewarded vs. unrewarded), and instructed learning (intentionally vs. incidentally encoded), preceding a delay consisting of a nap, an equivalent time period spent awake, or a nap followed by wakefulness (to control for effects of interference). Recognition testing revealed that when multiple dimensions of future relevance co-occur, sleep prioritizes top-down, goal-directed cues (instructed learning, and to a lesser degree, reward) over bottom-up, stimulus-driven characteristics (emotion). Further, results showed that these factors interact; the effect of a nap on intentionally encoded information was especially strong for neutral (relative to emotional) information, suggesting that once one cue for future relevance is present, there are diminishing returns with additional cues. Sleep may binarize information based on whether it is future-relevant or not, preferentially consolidating memory for the former category. Potential neural mechanisms underlying these selective effects and the implications of this research for educational and vocational domains are discussed. (PsycINFO Database Record PMID:27214500

  13. Redox metabolites signal polymicrobial biofilm development via the NapA oxidative stress cascade in Aspergillus

    PubMed Central

    Zheng, He; Kim, Jaekuk; Liew, Mathew; Yan, John K.; Herrera, Oscar; Bok, JinWoo; Kelleher, Neil L.; Keller, Nancy P.; Wang, Yun

    2014-01-01

    Summary Background Filamentous fungi and bacteria form mixed-species biofilms in nature and diverse clinical contexts. They secrete a wealth of redox-active small molecule secondary metabolites, which are traditionally viewed as toxins that inhibit growth of competing microbes. Results Here we report that these “toxins” can act as interspecies signals, affecting filamentous fungal development via oxidative stress regulation. Specifically, in co-culture biofilms, Pseudomonas aeruginosa phenazine-derived metabolites differentially modulated Aspergillus fumigatus development, shifting from weak vegetative growth to induced asexual sporulation (conidiation) along a decreasing phenazine gradient. The A. fumigatus morphological shift correlated with the production of phenazine radicals and concomitant reactive oxygen species (ROS) production generated by phenazine redox cycling. Phenazine conidiation signaling was conserved in the genetic model A. nidulans, and mediated by NapA, a homolog of AP-1-like bZIP transcription factor, which is essential for the response to oxidative stress in humans, yeast, and filamentous fungi. Expression profiling showed phenazine treatment induced a NapA-dependent response of the global oxidative stress metabolome including the thioredoxin, glutathione and NADPH-oxidase systems. Conidiation induction in A. nidulans by another microbial redox-active secondary metabolite, gliotoxin, also required NapA. Conclusions This work highlights that microbial redox metabolites are key signals for sporulation in filamentous fungi, which are communicated through an evolutionarily conserved eukaryotic stress response pathway. It provides a foundation for interspecies signaling in environmental and clinical biofilms involving bacteria and filamentous fungi. PMID:25532893

  14. General Education at the Coast Guard Academy.

    ERIC Educational Resources Information Center

    Sanders, William A.

    In seeking the most effective presentation of the liberal arts in curricula such as the heavily technical and professional curricula at the U.S. Coast Guard Academy, which leave little room for general education, general education course design must capture the imagination of students and motivate them for continuing self-education. Development of…

  15. Lafayette Academy Charter School: Safe and Predictable

    ERIC Educational Resources Information Center

    Principal Leadership, 2012

    2012-01-01

    This article features Lafayette Academy Charter School in New Orleans, Louisiana, which was recognized by the state board of education as a "center of excellence" in 2010, and given an automatic renewal of its charter--the only school in the state to receive this honor. The school has demonstrated impressive progress: the 2007 test results showed…

  16. Common Ground. Feminist Collaboration in the Academy.

    ERIC Educational Resources Information Center

    Peck, Elizabeth G., Ed.; Mink, JoAnna Stephens, Ed.

    The fifteen articles in this anthology examine the process of collaboration as it fits into questions of gender. Articles include: "Educate, Organize, and Agitate: A Historical Overview of Feminist Collaboration in Great Britain and America, 1640-1930" (Melodie Andrews); "Beyond Feminism: An Intercultural Challenge for Transforming the Academy"…

  17. Learning To Lead: The Galileo Leadership Academy.

    ERIC Educational Resources Information Center

    Kloosterhouse, Vicki

    2003-01-01

    Describes Michigan's Galileo Leadership Academy, a collaboration between K-12 and community college educators that develops leadership skills. Explains that 11 organizations participate in the program, and every two years each organization chooses five to nine leaders (primarily classroom educators) to be part of a new cohort. Asserts that the…

  18. Audience Perceptions of the Academy Awards Telecast.

    ERIC Educational Resources Information Center

    Real, Michael R.; Hassett, Christopher A.

    Residents in a southern California city were surveyed by telephone about their attitudes toward the telecast of the motion picture "Academy Awards" presentations. Of the 141 respondents, 71 had not watched the telecast, 42 had watched some of the broadcast, and 28 had watched all of it. Less than one third of the survey questions were specifically…

  19. How Academies Threaten the Comprehensive Curriculum

    ERIC Educational Resources Information Center

    Titcombe, Roger

    2008-01-01

    The Freedom of Information Act (FOI) was used over a three-year period to investigate the curriculum of state schools and academies. The resulting data has shown that spectacular apparent school improvement, in terms of five or more A*-C GCSE /GNVQ passes has been largely brought about by the substitution of mainstream curriculum subjects by much…

  20. Action Learning Drives the Emerald Academy

    ERIC Educational Resources Information Center

    Nalborczyk, Sarah; Sandelands, Luke

    2012-01-01

    This account examines the action learning process adopted by Emerald Group Publishing Ltd., embedded in the organization through the in-company Emerald Academy. In case study format, the paper emphasizes that in order to align learning with organizational objectives joined up thinking and practice is needed beyond the learning and development…

  1. Lost Leaders: Women in the Global Academy

    ERIC Educational Resources Information Center

    Morley, Louise

    2014-01-01

    Drawing on data gathered from British Council seminars in Hong Kong, Tokyo and Dubai on "Absent Talent: Women in Research and Academic Leadership" (2012-2013), this paper discusses academic women's experiences and explanations for women's under-representation as knowledge leaders and producers in the global academy.…

  2. Mater Academy Charter Middle School: Consistent Expectations

    ERIC Educational Resources Information Center

    Principal Leadership, 2010

    2010-01-01

    Mater Academy Charter Middle/High School is located in what was once a big box store in a commercial and industrial area of Hialeah Gardens, FL. The same energy that transformed a vacant store into a thriving campus for a grades 6-12 school is apparent in every classroom. Even the mayor of Hialeah Gardens credits the school with helping to…

  3. A Guide to the Evidence on Academies

    ERIC Educational Resources Information Center

    Sims, D.; Grayson, H.; Wespieser, K.

    2015-01-01

    Academic schools are a prominent feature of the educational landscape in England. Introduced in 2002, they are funded directly from central government and have become a major policy driver to reform the school system and increase educational attainment. Academies count for 60 percent of secondary schools and 13 percent of primaries. This report…

  4. Successful Transitions: The Sheyenne Ninth Grade Academy

    ERIC Educational Resources Information Center

    Hall, Brenda S.; Holland, Carol E. Buchholz; Karsh, Lisa; Wang, Ting

    2011-01-01

    In this article, we share outcomes from the implementation of a ninth-grade academy in a large, comprehensive, Northern Plains, United States, school district. The article discusses the effectiveness of this reform in terms of the academic and social preparedness for students during the ninth-grade year and transition to high school. Findings…

  5. Apprenticeship at the Academy of Music

    ERIC Educational Resources Information Center

    Nielsen, Klaus

    2006-01-01

    Inspired by studies of apprenticeship and theories of situated learning, this study argues that learning should be understood in relation to ongoing social practice. Using interview material and participant observation studying piano students' learning at the Academy of Music in Aarhus, it describes how transparency and access to the music culture…

  6. What Are Academies the Answer to?

    ERIC Educational Resources Information Center

    Gorard, Stephen

    2009-01-01

    This paper builds upon an earlier analysis presented in this journal. Using official figures for school compositions and for outcomes at KS4 from 1997 to 2007, this paper considers each of the annual cohorts of new Academies in England, from 2002 to 2006. It shows that their level of success in comparison to their predecessors, national averages,…

  7. Jupiter Environmental Research & Field Studies Academy.

    ERIC Educational Resources Information Center

    Huttemeyer, Bob

    1996-01-01

    Describes the development and workings of the Jupiter Environmental Research and Field Studies Academy that focuses on enabling both teachers and students to participate in real-life learning experiences. Discusses qualifications for admittance, curriculum, location, ongoing projects, students, academics, preparation for life, problem solving, and…

  8. Academy of the Canyons Report, Fall 2002.

    ERIC Educational Resources Information Center

    Meuschke, Daylene M.; Gribbons, Barry C.

    This report analyzes the Academy of the Canyons (AOC) program at College of the Canyons (COC), California. AOC, a middle college high school, is a collaboration between the William S. Hart High School District and College of the Canyons. The program is designed to provide a supportive, flexible, and academically enriched environment for students…

  9. The Academy for Career Education: Diffusion Issues.

    ERIC Educational Resources Information Center

    Maguire, Louis M.

    A model experience-based career education program for secondary school students in Philadelphia, called the Academy for Career Education, has been operated by Research for Better Schools, Inc. (RBS), for three years. It utilizes employer/community participants as instructional agents and learning sites for career exploration and specialization,…

  10. Researchers fear 'Putin's Academy of Sciences'

    NASA Astrophysics Data System (ADS)

    Moskvitch, Katia

    2013-11-01

    Scientists have voiced concerns about the future of the Russian Academy of Sciences (RAS) after the country's president, Vladimir Putin, signed a law that will make the 289-year-old body come under the direct control of a new government agency.

  11. Analysing Religion and Education in Christian Academies

    ERIC Educational Resources Information Center

    Green, Elizabeth

    2012-01-01

    This paper asserts that the religious assumptions of Christian academies need to be fully examined in relation to any analysis of their cultural practices, impact or policy implications. It proposes that Bourdieu's concepts of habitus, cultural capital and symbolic power can be broadened out from their traditional use in accounting for social…

  12. Charter Schools: Leadership Training Academy Workbook.

    ERIC Educational Resources Information Center

    Northwest Regional Educational Lab., Portland, OR.

    As part of the Model Leadership Training Program for charter-school founders and leaders, a workbook representing the training component developed during the first year was prepared. During the first year, 12 teams of charter-school founders and leaders (N=48) participated in the Charter School Leadership Training Academy. The workbook provides…

  13. American Academy of Podiatric Sports Medicine

    MedlinePlus

    ... Special Olympics Fit Feet Joint Commission on Sports Medicine & Science Medical Fitness Association Dr. Blakes Healing Sole Stop ... Injuries IRRA Sports Podiatry Runblogger Running Times The Science of ... Map Copyright © American Academy of Podiatric Sports Medicine Website Design, Maintenance and Hosting by Catalyst Marketing / ...

  14. Corporate Features and Faith-Based Academies

    ERIC Educational Resources Information Center

    Green, Elizabeth

    2009-01-01

    This article forms an introductory exploration into the relationship between corporate features and religious values in Academies sponsored by a Christian foundation. This is a theme which arose from research comprising the ethnography of a City Technology College (CTC) with a Christian ethos. The Christian foundation which sponsors the CTC also…

  15. Can Academic Freedom Work in Military Academies?

    ERIC Educational Resources Information Center

    Niday, Jackson A., II; Harrington, Kathleen

    2007-01-01

    This article addresses the thorny question of military discipline vs. academic freedom, demonstrating that the military academy is the perfect proving ground if you want to test the value of academic freedom. The authors, who are also Air Force officers, embarked on a two-year quest to determine what place academic freedom has at a military…

  16. The Press Research Centre, 1956-1976.

    ERIC Educational Resources Information Center

    Press Research Centre, Krakow (Poland).

    In 1956, the Press Research Centre was established in Cracow, Poland by a group of journalists and publishers, for the purpose of instituting press research that would have practical applications. The aims of the Centre were to conduct studies on the history of the Polish press, the contemporary press, press readership, and editorial techniques.…

  17. 75 FR 44276 - National Fire Academy Board of Visitors

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-28

    ... FR 39561) announcing a National Fire Academy Board of Visitors public teleconference meeting on... SECURITY Federal Emergency Management Agency National Fire Academy Board of Visitors AGENCY: Federal Emergency Management Agency, DHS. ACTION: Notice of cancellation of meeting. SUMMARY: The National...

  18. Developing a Project-Based Secondary School Science Academy

    NASA Astrophysics Data System (ADS)

    Adkins, J.

    2009-12-01

    For the past several years Deer Valley High School (Antioch, CA) has hosted a space academy known as the ESPACE academy (for Earth, Space Astronomy Center for Education). This academy has promoted original student primary research on astronomy and physics topics and initiated the school’s first entries into science fair and directed a number of students into science careers. During the next school year the Antioch Unified School District is supporting the expansion of the academy into a general science academy encompassing all areas of science, a move into a new building, and the development of a science academy model making it easier to integrate the academy into the larger school’s academic program. The presentation will discuss the design of the new academy and the involvement of students in projects connected to NASA’s WISE, Spitzer, and other missions.

  19. The U.S. Coast Guard Academy Curricula; An Evaluation.

    ERIC Educational Resources Information Center

    Powers, Theodore R.; And Others

    This report presents the results of research that had as its objective the evaluation of the curricula of the U.S. Coast Guard Academy. Over 125 Coast Guard officers and men were interviewed to gather detailed background information about the Coast Guard, the Coast Guard Academy, and job requirements of Academy graduates. These data were developed…

  20. Day of Dialogue: Research Priorities from the Researching Academies Conference

    ERIC Educational Resources Information Center

    Woods, Glenys J.; Woods, Philip A.

    2009-01-01

    The Researching Academies (RA) Conference, hosted by the University of Gloucestershire in Cheltenham on 12 November 2008 and organised by the authors, was a unique one-day event, funded as part of a research project (a case study of an Academy) supported by a British Academy (BA) grant, with additional support and funding from BELMAS. The RA…

  1. Haberdashers' Aske's: The Campaign against Academies in Lewisham

    ERIC Educational Resources Information Center

    Powell-Davies, Martin

    2008-01-01

    The National Union of Teachers' 2007 pamphlet "Academies--Looking Beyond the Spin: why the NUT calls for a different approach" lists six reasons why the NUT opposes Academies, schools run by private sponsors using public money. In this article, the Secretary of the Lewisham NUT presents evidence to show how the Academies operated by the…

  2. 76 FR 20696 - National Fire Academy Board of Visitors

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-13

    ... Federal Register at 76 FR 17425 that the National Fire Academy Board of Visitors would meet on April 6 and... SECURITY Federal Emergency Management Agency National Fire Academy Board of Visitors AGENCY: Federal... National Fire Academy Board of Visitors meeting was held on Wednesday, April 6, 2011, from 8:30 a.m. to 5...

  3. 76 FR 17425 - National Fire Academy Board of Visitors

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-29

    ... SECURITY Federal Emergency Management Agency National Fire Academy Board of Visitors AGENCY: Federal... Meeting. SUMMARY: The National Fire Academy Board of Visitors will meet on April 6-7, 2011. The meeting... the National Fire Academy Board of Visitors, go to http://www.regulations.gov . A public...

  4. 75 FR 39561 - National Fire Academy Board of Visitors

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-09

    ... SECURITY Federal Emergency Management Agency National Fire Academy Board of Visitors AGENCY: Federal... Meeting. SUMMARY: The National Fire Academy Board of Visitors will meet by teleconference on August 2... or comments received by the National Fire Academy Board of Visitors, go to...

  5. 75 FR 2153 - National Fire Academy Board of Visitors

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-14

    ... SECURITY Federal Emergency Management Agency National Fire Academy Board of Visitors AGENCY: Federal... Advisory Committee Meeting. SUMMARY: The National Fire Academy Board of Visitors will meet by... documents or comments received by the National Fire Academy Board of Visitors, go to...

  6. 75 FR 18524 - National Fire Academy Board of Visitors

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-12

    ... SECURITY Federal Emergency Management Agency National Fire Academy Board of Visitors AGENCY: Federal... Meeting. ] SUMMARY: The National Fire Academy Board of Visitors will meet on April 28-29, 2010. DATES: The... background documents or comments received by the National Fire Academy Board of Visitors, go to...

  7. The Brain Bank of America: Auditing the Academy

    ERIC Educational Resources Information Center

    Wade, Nicholas

    1975-01-01

    The National Academy of Sciences (NAS) comes under serious criticism for studies prepared by the academy's committees. It is recommended that the academy do less and do it better with emphasis on being more open and on presenting contrary points of view. (Author/EB)

  8. Action Research at St Mark's Academy 2013

    ERIC Educational Resources Information Center

    Elwick, Alex, Ed.; Riggall, Anna, Ed.

    2013-01-01

    St Mark's Church of England Academy is an 11-18 academy situated in Mitcham, South London. It offers a commitment to high achievement within a community of care, underpinned by the Christian values of hope, love and trust. The academy encourages the development of the moral and spiritual well-being of students, alongside their academic…

  9. The Racial History of the U.S. Military Academies.

    ERIC Educational Resources Information Center

    Hansen, Susan D.

    1999-01-01

    Presents the history of the entry of African American students and faculty into the nation's prestigious military institutions: the U.S. Military Academy at West Point, the U.S. Naval Academy at Annapolis, and the U.S. Air Force Academy in Colorado Springs. Notes that the military's effort to diversify its troops and officer corps is a recent…

  10. Investing in a Large Stretch Press

    NASA Technical Reports Server (NTRS)

    Choate, M.; Nealson, W.; Jay, G.; Buss, W.

    1986-01-01

    Press for forming large aluminum parts from plates provides substantial economies. Study assessed advantages and disadvantages of investing in large stretch-forming press, and also developed procurement specification for press.

  11. Predominance and high antibiotic resistance of the emerging Clostridium difficile genotypes NAPCR1 and NAP9 in a Costa Rican hospital over a 2-year period without outbreaks.

    PubMed

    López-Ureña, Diana; Quesada-Gómez, Carlos; Montoya-Ramírez, Mónica; del Mar Gamboa-Coronado, María; Somogyi, Teresita; Rodríguez, César; Rodríguez-Cavallini, Evelyn

    2016-01-01

    Clostridium difficile is the major causative agent of nosocomial antibiotic-associated diarrhea. In a 2009 outbreak of C. difficile-associated diarrhea that was recorded in a major Costa Rican hospital, the hypervirulent NAP1 strain (45%) predominated together with a local genotype variant (NAPCR1, 31%). Both strains were fluoroquinolone-resistant and the NAPCR1 genotype, in addition, was resistant to clindamycin and rifampicin. We now report on the genotypes and antibiotic susceptibilities of 68 C. difficile isolates from a major Costa Rican hospital over a 2-year period without outbreaks. In contrast to our previous findings, no NAP1 strains were detected, and for the first time in a Costa Rican hospital, a significant fraction of the isolates were NAP9 strains (n=14, 21%). The local NAPCR1 genotype remained prevalent (n=18, 26%) and coexisted with 14 strains (21%) of classic hospital NAP types (NAP2, NAP4, and NAP6), eight new genotypes (12%), four environmental strains classified as NAP10 or NAP11 (6%), three strains without NAP designation (4%) and seven non-toxigenic strains (10%). All 68 strains were resistant to ciprofloxacin, 88% were resistant to clindamycin and 50% were resistant to moxifloxacin and rifampicin. Metronidazole and vancomycin susceptibilities were universal. The NAPCR1 and NAP9 strains, which have been associated with more severe clinical infections, were more resistant to antibiotics than the other strains. Altogether, our results confirm that the epidemiology of C. difficile infection is dynamic and that A(-)B(+) strains from the NAP9 type are on the rise not only in the developed world. Moreover, our results reveal that the local NAPCR1 strains still circulate in the country without causing outbreaks but with equally high antibiotic-resistance rates and levels. PMID:27165560

  12. Predominance and high antibiotic resistance of the emerging Clostridium difficile genotypes NAPCR1 and NAP9 in a Costa Rican hospital over a 2-year period without outbreaks

    PubMed Central

    López-Ureña, Diana; Quesada-Gómez, Carlos; Montoya-Ramírez, Mónica; del Mar Gamboa-Coronado, María; Somogyi, Teresita; Rodríguez, César; Rodríguez-Cavallini, Evelyn

    2016-01-01

    Clostridium difficile is the major causative agent of nosocomial antibiotic-associated diarrhea. In a 2009 outbreak of C. difficile-associated diarrhea that was recorded in a major Costa Rican hospital, the hypervirulent NAP1 strain (45%) predominated together with a local genotype variant (NAPCR1, 31%). Both strains were fluoroquinolone-resistant and the NAPCR1 genotype, in addition, was resistant to clindamycin and rifampicin. We now report on the genotypes and antibiotic susceptibilities of 68 C. difficile isolates from a major Costa Rican hospital over a 2-year period without outbreaks. In contrast to our previous findings, no NAP1 strains were detected, and for the first time in a Costa Rican hospital, a significant fraction of the isolates were NAP9 strains (n=14, 21%). The local NAPCR1 genotype remained prevalent (n=18, 26%) and coexisted with 14 strains (21%) of classic hospital NAP types (NAP2, NAP4, and NAP6), eight new genotypes (12%), four environmental strains classified as NAP10 or NAP11 (6%), three strains without NAP designation (4%) and seven non-toxigenic strains (10%). All 68 strains were resistant to ciprofloxacin, 88% were resistant to clindamycin and 50% were resistant to moxifloxacin and rifampicin. Metronidazole and vancomycin susceptibilities were universal. The NAPCR1 and NAP9 strains, which have been associated with more severe clinical infections, were more resistant to antibiotics than the other strains. Altogether, our results confirm that the epidemiology of C. difficile infection is dynamic and that A−B+ strains from the NAP9 type are on the rise not only in the developed world. Moreover, our results reveal that the local NAPCR1 strains still circulate in the country without causing outbreaks but with equally high antibiotic-resistance rates and levels. PMID:27165560

  13. Hanford Patrol Academy demolition sites closure plan

    SciTech Connect

    Not Available

    1993-09-30

    The Hanford Site is owned by the U.S. Government and operated by the U.S. Department of Energy, Richland Operations Office. Westinghouse Hanford Company is a major contractor to the U.S. Department of Energy, Richland Operations Office and serves as co-operator of the Hanford Patrol Academy Demolition Sites, the unit addressed in this paper. This document consists of a Hanford Facility Dangerous Waste Part A Permit Application, Form 3 (Revision 4), and a closure plan for the site. An explanation of the Part A Form 3 submitted with this closure plan is provided at the beginning of the Part A section. This Hanford Patrol Academy Demolition Sites Closure Plan submittal contains information current as of December 15, 1994.

  14. ["The thirties" academy (politics and medicine)].

    PubMed

    Sánchez Granjel, Luis

    2008-01-01

    In the last century thirties the dictatorship overthrow brought to the Spanish people's life a period of political vehemence which influenced the life of the Academy; this fact gave as a result a completely new situation in its history; this situation is being analyzed in this study which is based on the information that comes from the Record Office and the medical journalism of that age. PMID:18777844

  15. Work schedule and self-reported hypertension - the potential beneficial role of on-shift naps for night workers.

    PubMed

    Rotenberg, Lúcia; Silva-Costa, Aline; Vasconcellos-Silva, Paulo Roberto; Griep, Rosane Härter

    2016-01-01

    Data on the association between shift work and hypertension are controversial. Sleep restriction is hypothesized to be involved in this relationship. Since on-shift nap can partly compensate for sleep deprivation among night workers, this investigation is aimed at (i) comparing the prevalence of hypertension among workers considering both current and former night work, (ii) testing the association between on-shift naps and hypertension among night workers, and (iii) analyzing the influence of sleep complaints in the association between on-shift nap and hypertension. Nap was defined as a sleep episode with duration shorter than the average nighttime sleep. A cross-sectional study was performed at the 18 largest public hospitals in Rio de Janeiro, Brazil, in 2010-2011 (N = 2588 female registered nurses). Nurses were informally allowed to nap for up to three consecutive hours during working nights. Workers completed a multidimensional questionnaire including self-reported information on physician diagnosis of hypertension, napping, and sleep complaints (insomnia, diurnal sleepiness, and non-satisfactory sleep). Epidemiological and statistical treatment of data included binomial logistic regression and interaction tests. Higher chances of hypertension were observed for both current and former night workers compared with workers with no previous experience in night work, i.e. exclusive day workers (OR = 1.68; CI95% 1.22-2.33 and OR = 1.40; CI95% 1.01-1.96, respectively) after adjustment for age, race/ethnicity, physical activity, smoking, alcohol consumption, insomnia, weekly work hours, and BMI. Compared with exclusive day workers, both non-nappers and nappers were at a higher likelihood of reporting hypertension (OR = 1.93 CI95% 1.35-2.79 and OR = 1.41 CI95% 1.08-2.20, respectively). An interaction was observed between napping behavior and insomnia (p = 0.037). In the whole sample of night workers, the lower OR for nappers was confirmed when they were directly

  16. REM-Enriched Naps Are Associated with Memory Consolidation for Sad Stories and Enhance Mood-Related Reactivity

    PubMed Central

    Gilson, Médhi; Deliens, Gaétane; Leproult, Rachel; Bodart, Alice; Nonclercq, Antoine; Ercek, Rudy; Peigneux, Philippe

    2015-01-01

    Emerging evidence suggests that emotion and affect modulate the relation between sleep and cognition. In the present study, we investigated the role of rapid-eye movement (REM) sleep in mood regulation and memory consolidation for sad stories. In a counterbalanced design, participants (n = 24) listened to either a neutral or a sad story during two sessions, spaced one week apart. After listening to the story, half of the participants had a short (45 min) morning nap. The other half had a long (90 min) morning nap, richer in REM and N2 sleep. Story recall, mood evolution and changes in emotional response to the re-exposure to the story were assessed after the nap. Although recall performance was similar for sad and neutral stories irrespective of nap duration, sleep measures were correlated with recall performance in the sad story condition only. After the long nap, REM sleep density positively correlated with retrieval performance, while re-exposure to the sad story led to diminished mood and increased skin conductance levels. Our results suggest that REM sleep may not only be associated with the consolidation of intrinsically sad material, but also enhances mood reactivity, at least on the short term. PMID:26729175

  17. NAP (davunetide) protects primary hippocampus culture by modulating expression profile of antioxidant genes during limiting oxygen conditions.

    PubMed

    Arya, A; Meena, R; Sethy, N K; Das, M; Sharma, M; Bhargava, K

    2015-04-01

    Hypoxia is a well-known threat to neuronal cells and triggers the pathophysiological syndromes in extreme environments such as high altitudes and traumatic conditions such as stroke. Among several prophylactic molecules proven suitable for ameliorating free radical damage, NAP (an octapeptide with initial amino acids: asparagine/N, alanine/A, and proline/P) can be considered superlative, primarily due to its high permeability into brain through blood-brain barrier and observed activity at femtomolar concentrations. Several mechanisms of action of NAP have been hypothesized for its protective role during hypoxia, yet any distinct mechanism is unknown. Oxidative stress is advocated as the leading event in hypoxia; we, therefore, investigated the regulation of key antioxidant genes to understand the regulatory role of NAP in providing neuroprotection. Primary neuronal culture of rat was subjected to cellular hypoxia by limiting the oxygen concentration to 0.5% for 72 h and observing the prophylactic efficacies of 15fM NAP by conventional cell death assays using flow cytometry. We performed real-time quantitative polymerase chain reaction to comprehend the regulatory mechanism. Further, we validated the significantly regulated candidates by enzyme assays and immunoblotting. In the present study, we report that NAP regulates a major clad of cellular antioxidants and there is an involvement of more than one route of action in neuroprotection during hypoxia. PMID:25727410

  18. REM-Enriched Naps Are Associated with Memory Consolidation for Sad Stories and Enhance Mood-Related Reactivity.

    PubMed

    Gilson, Médhi; Deliens, Gaétane; Leproult, Rachel; Bodart, Alice; Nonclercq, Antoine; Ercek, Rudy; Peigneux, Philippe

    2015-01-01

    Emerging evidence suggests that emotion and affect modulate the relation between sleep and cognition. In the present study, we investigated the role of rapid-eye movement (REM) sleep in mood regulation and memory consolidation for sad stories. In a counterbalanced design, participants (n = 24) listened to either a neutral or a sad story during two sessions, spaced one week apart. After listening to the story, half of the participants had a short (45 min) morning nap. The other half had a long (90 min) morning nap, richer in REM and N2 sleep. Story recall, mood evolution and changes in emotional response to the re-exposure to the story were assessed after the nap. Although recall performance was similar for sad and neutral stories irrespective of nap duration, sleep measures were correlated with recall performance in the sad story condition only. After the long nap, REM sleep density positively correlated with retrieval performance, while re-exposure to the sad story led to diminished mood and increased skin conductance levels. Our results suggest that REM sleep may not only be associated with the consolidation of intrinsically sad material, but also enhances mood reactivity, at least on the short term. PMID:26729175

  19. STEM Summer Academy on the Navajo Reservation

    NASA Astrophysics Data System (ADS)

    Alexander, C. J.

    2012-12-01

    The US Rosetta Project is the NASA contribution to the International Rosetta Mission, an ESA cornerstone mission to comet Churyumov-Gerasimenko. While the project's outreach efforts span multi-media, and a variety of age and ethnic groups, a special emphasis has been made to find a way to provide meaningful outreach to the reservation communities. Because language preservation is an issue of urgent concern to the reservation communities, and because Rosetta, uniquely among NASA missions, has been named after the notion that keys to missing understanding of elements of the ancient past were found in the language on the original Rosetta stone, the US Rosetta Project has embarked upon outreach with a focus on STEM vocabulary in ancient US languages of the Navajo, Hopi, Ojibwe, and other tribal communities as the project expands. NASA image and science are used and described in the native language, alongside lay English and scientific English curriculum elements. Additionally, science (geology/chemistry/botany/physics) elements drawn from the reservation environment, including geomorphology, geochemistry, soil physics, are included and discussed in the native language as much as possible — with their analogs in other planetary environments (such as Mars). In this paper we will report on the most recent Summer Science Academy [2012], a four week summer course for middle school children, created in collaboration with teachers and administrators in the Chinle Unified School District. The concept of the Academy was initiated in 2011, and the first Academy was conducted shortly thereafter, in June 2011 with 14 children, 3 instructors, and a NASA teacher workshop. The community requested three topics: geology, astronomy, and botany. The 2012 Academy built on the curriculum already developed with more robust field trips, addressed to specific science topics, additional quantitative measurements and activities, with more written material for the cultural components from

  20. Nap environment control considering respiration rate and music tempo by using sensor agent robot

    NASA Astrophysics Data System (ADS)

    Nakaso, Sayaka; Mita, Akira

    2015-03-01

    We propose a system that controls a nap environment considering respiration rates and music tempo by using a sensor agent robot. The proposed system consists of two sub-systems. The first sub-system measures respiration rates using optical flow. We conducted preparatory experiments to verify the accuracy of this sub-system. The experimental results showed that this sub-system can measure the respiration rates accurately despite several positional relationships. It was also shown that the accuracy could be affected by clothes, movements and light. The second sub-system we constructed was the music play sub-system that chooses music with the certain tempo corresponding to the respiration rates measured by the first sub-system. We conducted verification experiments to verify the effectiveness of this music play sub-system. The experimental results showed the effectiveness of varying music tempo based on the respiration rates in taking a nap. We also demonstrated this system in a real environment; a subject entered into the room being followed by ebioNα. When the subject was considered sleeping, ebioNα started measuring respiration rates, controlling music based on the respiration rates. As a result, we showed that this system could be realized. As a next step, we would like to improve this system to a nap environment control system to be used in offices. To realize this, we need to update the first sub-system measuring respiration rates by removing disturbances. We also need to upgrade music play sub-system considering the numbers of tunes, the kinds of music and time to change music.

  1. Experience-dependent induction of hypnagogic images during daytime naps: a combined behavioural and EEG study.

    PubMed

    Kusse, Caroline; Shaffii-LE Bourdiec, Anahita; Schrouff, Jessica; Matarazzo, Luca; Maquet, Pierre

    2012-02-01

    This study characterizes hypnagogic hallucinations reported during a polygraphically recorded 90-min daytime nap following or preceding practice of the computer game Tetris. In the experimental group (N = 16), participants played Tetris in the morning for 2 h during three consecutive days, while in a first control group (N = 13, controlling the effect of experience) participants did not play any game, and in a second control group (N = 14, controlling the effect of anticipation) participants played Tetris after the nap. During afternoon naps, participants were repetitively awakened 15, 45, 75, 120 or 180 s after the onset of S1, and were asked to report their mental content. Reports content was scored by three judges (inter-rater reliability 85%). In the experimental group, 48 out of 485 (10%) sleep-onset reports were Tetris-related. They mostly consisted of images and sounds with very little emotional content. They exactly reproduced Tetris elements or mixed them with other mnemonic components. By contrast, in the first control group, only one report out of 107 was scored as Tetris-related (1%), and in the second control group only three reports out of 112 were scored as Tetris-related (3%; between-groups comparison; P = 0.006). Hypnagogic hallucinations were more consistently induced by experience than by anticipation (P = 0.039), and they were predominantly observed during the transition of wakefulness to sleep. The observed attributes of experience-related hypnagogic hallucinations are consistent with the particular organization of regional brain activity at sleep onset, characterized by high activity in sensory cortices and in the default-mode network. PMID:21848802

  2. First Report of Clostridium difficile NAP1/027 in a Mexican Hospital

    PubMed Central

    Camacho-Ortiz, Adrián; López-Barrera, Daniel; Hernández-García, Raúl; Galván-De los Santos, Alejandra M.; Flores-Treviño, Samantha M.; Llaca-Díaz, Jorge M.; Garza, Héctor J. Maldonado; Bosques-Padilla, Francisco J.; Garza-González, Elvira

    2015-01-01

    Background and Objective Clostridium difficile NAP1/ribotype 027 is associated with severe disease and high mortality rates. Our aim was to determine the prevalence of NAP1/ribotype 027 among C. difficile isolates in a tertiary care hospital, and review the main clinical data. Methods We included 106 stool samples from 106 patients. Samples were tested for A&B toxins and were cultured on CCFA agar. The genes tcdA, tcdB, tcdC, cdtA, and cdtB were amplified using PCR in clinical isolates. The tcdA 3’-end deletion analysis, PCR-ribotyping, and pulsed-field gel electrophoresis (PFGE) were also performed. Stool samples that were positive for culture were tested by the GeneXpert C. difficile assay. Clinical data were collected. Results Thirty-six patients tested positive for A&B toxins; and 22 patients had positive culture for C. difficile, 14 of which tested positive for the A&B toxins and all 22 patients tested positive by the GeneXpert C. difficile assay. Risk factors included an average hospital stay of 16.1 days prior to toxin detection, average antibiotic use for 16.2 days, and a median of 3 antibiotics used. The 30-day crude mortality rate was 8.4%. Six of the 22 patients died, and 3 of those deaths were directly attributed to C. difficile infection. The majority of isolates, 90.9% (20/22), carried genes tcdB, tcdA, cdtA, and cdtB; and these strains carried the corresponding downregulator gene tcdC, with an 18-bp deletion. PFGE was performed on 17 isolates, and one main pattern was observed. Analysis of the ribotyping data showed similar results. Conclusion The above findings represent the clonal spread of C. difficile in our institution, which mainly includes the NAP1/027 strain. This is the first report of C. difficile ribotype NAP1/027 in Mexico. PMID:25915544

  3. OsNAP connects abscisic acid and leaf senescence by fine-tuning abscisic acid biosynthesis and directly targeting senescence-associated genes in rice

    PubMed Central

    Liang, Chengzhen; Wang, Yiqin; Zhu, Yana; Tang, Jiuyou; Hu, Bin; Liu, Linchuan; Ou, Shujun; Wu, Hongkai; Sun, Xiaohong; Chu, Jinfang; Chu, Chengcai

    2014-01-01

    It has long been established that premature leaf senescence negatively impacts the yield stability of rice, but the underlying molecular mechanism driving this relationship remains largely unknown. Here, we identified a dominant premature leaf senescence mutant, prematurely senile 1 (ps1-D). PS1 encodes a plant-specific NAC (no apical meristem, Arabidopsis ATAF1/2, and cup-shaped cotyledon2) transcriptional activator, Oryza sativa NAC-like, activated by apetala3/pistillata (OsNAP). Overexpression of OsNAP significantly promoted senescence, whereas knockdown of OsNAP produced a marked delay of senescence, confirming the role of this gene in the development of rice senescence. OsNAP expression was tightly linked with the onset of leaf senescence in an age-dependent manner. Similarly, ChIP-PCR and yeast one-hybrid assays demonstrated that OsNAP positively regulates leaf senescence by directly targeting genes related to chlorophyll degradation and nutrient transport and other genes associated with senescence, suggesting that OsNAP is an ideal marker of senescence onset in rice. Further analysis determined that OsNAP is induced specifically by abscisic acid (ABA), whereas its expression is repressed in both aba1 and aba2, two ABA biosynthetic mutants. Moreover, ABA content is reduced significantly in ps1-D mutants, indicating a feedback repression of OsNAP on ABA biosynthesis. Our data suggest that OsNAP serves as an important link between ABA and leaf senescence. Additionally, reduced OsNAP expression leads to delayed leaf senescence and an extended grain-filling period, resulting in a 6.3% and 10.3% increase in the grain yield of two independent representative RNAi lines, respectively. Thus, fine-tuning OsNAP expression should be a useful strategy for improving rice yield in the future. PMID:24951508

  4. [Feeding habitat of red-crowned crane and white-napped crane during their courtship period in Zhalong wetland].

    PubMed

    Zou, Hongfei; Wu, Qingming

    2006-03-01

    By the methods of fixed-spot observation, GPS positioning, plot sampling measurement and factor analysis, a comparative study was made on the feeding habitat of red-crowned and white-napped crane during their courtship period (from March to April) in Zhalong Nature Reserve in 2003 and 2004. The results showed that red-crowned crane preferred unique habitat for feed, mostly focused on water field (e. g., reed marsh). During its selection of microhabitat, food factor played a crucial role, followed by concealment factor, water factor, and identification factor. The feeding habitat of white-napped crane was of diversification, and dry field, e. g., Carex marsh, farmland and burned field, was the priority. White-napped crane had a strict requirement in selecting feeding microhabitat, with "valid food" factor as the most important ingredient, and disturbance and water factors as the subordinate one. PMID:16724740

  5. Enhancement of Declarative Memory Performance Following a Daytime Nap Is Contingent on Strength of Initial Task Acquisition

    PubMed Central

    Tucker, Matthew A.; Fishbein, William

    2008-01-01

    Study Objectives: In this study we examined the benefit of a daytime nap containing only NREM sleep on the performance of three declarative memory tasks: unrelated paired associates, maze learning, and the Rey-Osterrieth complex figure. Additionally, we explored the impact of factors related to task acquisition on sleep-related memory processing. To this end, we examined whether testing of paired associates during training leads to sleep-related enhancement of memory compared to simply learning the word pairs without test. We also examined whether strength of task acquisition modulates sleep-related processing for each of the three tasks. Subjects and Procedure: Subjects (11 male, 22 female) arrived at 11:30, were trained on each of the declarative memory tasks at 12:15, and at 13:00 either took a nap or remained awake in the sleep lab. After the nap period, all subjects remained in the lab until retest at 16:00. Results: Compared to subjects who stayed awake during the training-retest interval, subjects who took a NREM nap demonstrated enhanced performance for word pairs that were tested during training, but not for untested word pairs. For each of the three declarative memory tasks, we observed a sleep-dependent performance benefit only for subjects that most strongly acquired the tasks during the training session. Conclusions: NREM sleep obtained during a daytime nap benefits declarative memory performance, with these benefits being intimately tied to how well subjects acquire the tasks and the way in which the information is acquired. Citation: Tucker MA; Fishbein W. Enhancement of declarative memory performance following a daytime nap is contingent on strength of initial task acquisition. SLEEP 2008;31(2):197–203. PMID:18274266

  6. Benefits of napping and an extended duration of recovery sleep on alertness and immune cells after acute sleep restriction.

    PubMed

    Faraut, Brice; Boudjeltia, Karim Zouaoui; Dyzma, Michal; Rousseau, Alexandre; David, Elodie; Stenuit, Patricia; Franck, Thierry; Van Antwerpen, Pierre; Vanhaeverbeek, Michel; Kerkhofs, Myriam

    2011-01-01

    Understanding the interactions between sleep and the immune system may offer insight into why short sleep duration has been linked to negative health outcomes. We, therefore, investigated the effects of napping and extended recovery sleep after sleep restriction on the immune and inflammatory systems and sleepiness. After a baseline night, healthy young men slept for a 2-h night followed by either a standard 8-h recovery night (n=12), a 30-min nap (at 1 p.m.) in addition to an 8-h recovery night (n=10), or a 10-h extended recovery night (n=9). A control group slept 3 consecutive 8-h nights (n=9). Subjects underwent continuous electroencephalogram polysomnography and blood was sampled every day at 7 a.m. Leukocytes, inflammatory and atherogenesis biomarkers (high-sensitivity C-reactive protein, interleukin-8, myeloperoxidase, fibrinogen and apolipoproteins ApoB/ApoA), sleep patterns and sleepiness were investigated. All parameters remained unchanged in the control group. After sleep restriction, leukocyte and - among leukocyte subsets - neutrophil counts were increased, an effect that persisted after the 8-h recovery sleep, but, in subjects who had a nap or a 10-h recovery sleep, these values returned nearly to baseline. Inflammatory and atherogenesis biomarkers were unchanged except for higher myeloperoxidase levels after sleep restriction. The increased sleepiness after sleep restriction was reversed better in the nap and extended sleep recovery conditions. Saliva cortisol decreased immediately after the nap. Our results indicate that additional recovery sleep after sleep restriction provided by a midday nap prior to recovery sleep or a sleep extended night can improve alertness and return leukocyte counts to baseline values. PMID:20699115

  7. Geothermal Academy: Focus Center for Data Collection, Analysis, and Dissemination

    SciTech Connect

    Nakagawa, Masami, Ph.D.; Fujiono, Hendro, Ph.D.; McCartney, John S., Ph.D.; Reed, Adam, J.D., Esq.

    2011-10-31

    Geothermal Academy: A Pathway for Confirmation of Ground-Source Heat Pumps in the United States. In 2008, Oak Ridge National Laboratory issued a report on geothermal heats pumps (GHPs) focused on the market status, barriers to adoption, and actions to overcome these barriers (Hughes 2008). Of the barriers raised in this report, of the most pressing is the lack of performance and energy usage data for GHPs. Further, an associated barrier is a lack of a fair comparison of the energy usage of conventional heating and cooling systems for the same building. Because of these barriers, we are not able to say how much energy is used by well-designed GHP systems on a long-term basis, nor are we able to say how better their energy usage is compared to conventional systems. The need for a fair comparison with conventional systems is particularly relevant as modern versions of conventional air conditioners, gas furnaces, and boilers have also incorporated energy saving technologies. As a first step to address this barrier, the Geothermal Academy has developed a framework for data collection. This framework has already been applied to several geothermal installations in Colorado (Nakagawa etal. 2010). The framework classifies data into different categories based on the relevance of the dat to understanding the energy consumption of a GHP system. The categories are: direct energy consumption data, heat exchange performance data, and GHP design parameter data. The main recommendation of this project is to include a minimal data collection system on each heat pump installed in the U.S., capable of measuring the electrical energy consumed, the entering/exiting fluid temperatures, and circulation rates. This is a viable and cost effective solution which will provide performance data, as data collection systems are only a fraction of the cost of a GHP unit and modern GHP units already incorporate sensors to monitor energy usage and the entering and exiting fluid temperatures

  8. Characterization of Clostridium difficile Strains in British Columbia, Canada: A Shift from NAP1 Majority (2008) to Novel Strain Types (2013) in One Region

    PubMed Central

    Jassem, Agatha N.; Prystajecky, Natalie; Marra, Fawziah; Kibsey, Pamela; Tan, Kennard; Umlandt, Patricia; Janz, Loretta; Champagne, Sylvie; Gamage, Bruce; Golding, George R.; Mulvey, Michael R.; Henry, Bonnie

    2016-01-01

    Background. Clostridium difficile is a major cause of gastrointestinal illness. Epidemic NAP1 strains contain toxins A and B, a deletion in repressor tcdC, and a binary toxin. Objectives. To determine the molecular epidemiology of C. difficile in British Columbia and compare between two time points in one region. Methods. C. difficile isolates from hospital and community laboratories (2008) and one Island Health hospital laboratory (2013) were characterized by pulsed-field gel electrophoresis, PCR-ribotyping, toxin possession, tcdC genotype, and antimicrobial susceptibility. Results. In 2008, 42.7% of isolates had NAP1 designation. Hospital-collected isolates were associated with older patients and more NAP1 types. Unlike other isolates, most NAP1 isolates possessed binary toxin and a 19 bp loss in tcdC. All isolates were susceptible to metronidazole and vancomycin. A 2013 follow-up revealed a 28.9% decrease in NAP1 isolates and 20.0% increase in isolates without NAP designation in one region. Then, community-associated cases were seen in younger patients, while NAP types were evenly distributed. Isolates without NAP designation did not cluster with a PFGE pattern or ribotype. Conclusions. Evaluation of C. difficile infections within British Columbia revealed demographic associations, epidemiological shifts, and characteristics of strain types. Continuous surveillance of C. difficile will enable detection of emerging strains. PMID:27366181

  9. No first night shift effect observed following a nocturnal main sleep and a prophylactic 1-h afternoon nap.

    PubMed

    Kosmadopoulos, Anastasi; Zhou, Xuan; Roach, Gregory D; Darwent, David; Sargent, Charli

    2016-01-01

    Neurobehavioural impairment on the first night shift is often greater than on subsequent night shifts due to extended wakefulness. The aim of the study was to determine whether a 1-h afternoon nap prior to the first night shift is sufficient to produce neurobehavioural performance at levels comparable to the second night shift. Twelve male volunteers (mean age 22.9 years) participated in a laboratory protocol that simulated two 12-h night shifts. A nap preceded the first shift and a 7-h daytime sleep was scheduled between shifts. Neurobehavioural performance and subjective sleepiness measured across each night did not significantly differ between first and second shifts. PMID:27077691

  10. Napping during the night shift and recovery after work among hospital nurses1

    PubMed Central

    Palermo, Thaís Aparecida de Castro; Rotenberg, Lúcia; Zeitoune, Regina Célia Gollner; Silva-Costa, Aline; Souto, Ester Paiva; Griep, Rosane Härter

    2015-01-01

    OBJECTIVE: To analyze the association between the length of napping during the night shift and the recovery after work among nurses. METHOD: Cross-sectional epidemiological study involving 1940 nurses from 18 public hospitals in the City of Rio de Janeiro. A multidimensional and self-applied questionnaire was used with information about health, sociodemographic and occupational characteristics, health-related behaviors and housework. Multiple logistic regression was applied to identify the association, adjusted for confounding variables. RESULTS: The gross analyses showed 44%, 127% and 66% higher chances of a high level of recovery after work for nurses who sleep up to two hours, between 2.1 and 3 hours and 3.1 hours or more, respectively, when compared to the nurses who do not sleep. After adjusting for confounding variables, the association only continues significant for the group that sleeps 2.1 to 3 hours during the night shift (OR=1.79; 95%CI=1.33-2.41). CONCLUSION: The association between the length of napping and the high level of recovery after work, confirmed in the present results, can be included in the studies that aim to support more appropriate policies aimed at improving the workers' work, life and health conditions, not only in nursing, but night-shift workers in general. PMID:25806639

  11. Synthesis of NaP zeolite at room temperature and short crystallization time by sonochemical method.

    PubMed

    Pal, Pameli; Das, Jugal K; Das, Nandini; Bandyopadhyay, Sibdas

    2013-01-01

    NaP zeolite nano crystals were synthesized by sonochemical method at room temperature with crystallization time of 3h. For comparison, to insure the effect of sonochemical method, the hydrothermal method at conventional synthesis condition, with same initial sol composition was studied. NaP zeolites are directly formed by ultrasonic treatment without the application of autogenous pressure and also hydrothermal treatment. The effect of ultrasonic energy and irradiation time showed that with increasing sonication energy, the crystallinity of the powders decreased but phase purity remain unchanged. The synthesized powders were characterized by XRD, IR, DTA TGA, FESEM, and TEM analysis. FESEM images revealed that 50 nm zeolite crystals were formed at room temperature by using sonochemical method. However, agglomerated particles having cactus/cabbage like structure was obtained by sonochemical method followed by hydrothermal treatment. In sonochemical process, formation of cavitation and the collapsing of bubbles produced huge energy which is sufficient for crystallization of zeolite compared to that supplied by hydrothermal process for conventional synthesis. With increasing irradiation energy and time, the crystallinity of the synthesized zeolite samples increased slightly. PMID:22922038

  12. The Teachers Academy for Mathematics and Science

    SciTech Connect

    Not Available

    1992-01-01

    In his State of the Union address on January 31, 1990, President Bush set a goal for US students to be number one in the world in mathematics and science achievement by the year 2000. The Teachers Academy for Mathematics and Science in Chicago is an experiment of unprecedented boldness and scale that can provide a means to the President's goal, both for the Chicago area and as a national model. This document covers organization and governance, program activities, future training goals, and evaluation programs.

  13. Case Presentations from the Addiction Academy.

    PubMed

    Laes, JoAn R; Wiegand, Timothy

    2016-03-01

    In this article, a case-based format is used to address complex clinical issues in addiction medicine. The cases were developed from the authors' practice experience, and were presented at the American College of Medical Toxicology Addiction Academy in 2015. Section I: Drug and Alcohol Dependence and Pain explores cases of patients with co-occurring pain and substance use disorders. Section II: Legal and Policy Issues in Substance Use Disorders highlights difficult legal and policy questions in addiction medicine. Section III: Special Populations and Addictive Disorders delves into the complexity of addiction in special populations (pregnant, pediatric, and geriatric patients). PMID:26586253

  14. Daytime Napping and the Risk of Cardiovascular Disease and All-Cause Mortality: A Prospective Study and Dose-Response Meta-Analysis

    PubMed Central

    Yamada, Tomohide; Hara, Kazuo; Shojima, Nobuhiro; Yamauchi, Toshimasa; Kadowaki, Takashi

    2015-01-01

    Study Objectives: To summarize evidence about the association between daytime napping and the risk of cardiovascular disease and all-cause mortality, and to quantify the potential dose-response relation. Design: Meta-analysis of prospective cohort studies. Methods and Results: Electronic databases were searched for articles published up to December 2014 using the terms nap, cardiovascular disease, and all-cause mortality. We selected well-adjusted prospective cohort studies reporting risk estimates for cardiovascular disease and all-cause mortality related to napping. Eleven prospective cohort studies were identified with 151,588 participants (1,625,012 person-years) and a mean follow-up period of 11 years (60% women, 5,276 cardiovascular events, and 18,966 all-cause deaths). Pooled analysis showed that a long daytime nap (≥ 60 min/day) was associated with a higher risk of cardiovascular disease (rate ratio [RR]: 1.82 [1.22–2.71], P = 0.003, I2 = 37%) compared with not napping. All-cause mortality was associated with napping for ≥ 60 min/day (RR: 1.27 [1.11–1.45], P < 0.001, I2 = 0%) compared with not napping. In contrast, napping for < 60 min/day was not associated with cardiovascular disease (P = 0.98) or all-cause mortality (P = 0.08). Meta-analysis demonstrated a significant J-curve dose-response relation between nap time and cardiovascular disease (P for nonlinearity = 0.01). The RR initially decreased from 0 to 30 min/day. Then it increased slightly until about 45 min/day, followed by a sharp increase at longer nap times. There was also a positive linear relation between nap time and all-cause mortality (P for non-linearity = 0.97). Conclusions: Nap time and cardiovascular disease may be associated via a J-curve relation. Further studies are needed to confirm the efficacy of a short nap. Citation: Yamada T, Hara K, Shojima N, Yamauchi T, Kadowaki T. Daytime napping and the risk of cardiovascular disease and all-cause mortality: a prospective study and

  15. Apollo 13 Facts: Press Conference

    NASA Technical Reports Server (NTRS)

    2001-01-01

    Flight Director Gene Krantz gives an overview of the Apollo 13 mission as corrections are made in the power down checklist, passive thermal control, and orbital burns after the spacecraft runs into problems. He then answers questions from the press with the help of Tony England, Bill Peters, and Dick Thorson. Footage then shows newspaper headlines 'We're Not Concerned' and 'Getting Ready to Land' as people watch televisions to see if the astronauts landed safely. The press conference section of this video has sound, the headlines section does not.

  16. Job demands and resting and napping opportunities for nurses during night shifts: impact on sleepiness and self-evaluated quality of healthcare

    PubMed Central

    BARTHE, Béatrice; TIRILLY, Ghislaine; GENTIL, Catherine; TOUPIN, Cathy

    2015-01-01

    The aim of this field study is to describe night shift resting and napping strategies and to examine their beneficial effects on sleepiness and quality of work. The study was carried out with 16 nurses working in an intensive care unit. Data collected during 20 night shifts were related to job demands (systematic observations), to the duration and timing of rests and naps taken by nurses (systematic observations, sleep diaries), to sleepiness (Karolinska Sleepiness Scale), and to quality of work scores (visual analog scale). The results showed that the number of rests and naps depended on the job demands. Resting and napping lowered the levels of sleepiness at the end of the shift. There was no direct relationship between sleepiness and the quality of work score. Discussions about the choice of indicators for the quality of work are necessary. Suggestions for implementing regulations for prescribed napping during night shifts are presented. PMID:26537999

  17. An Academy for the Social Sciences: An Academy for the 21st Century.

    ERIC Educational Resources Information Center

    Turner, David

    2002-01-01

    Presents a personal view of the development of Britain's new Academy of Learned Societies for the Social Sciences. Discusses efforts to ensure that the new organization is inclusive, reflects balance in a number of ways, and is capable of self-reform to meet changing circumstances in the future. (EV)

  18. Women in the Military Academies: US Air Force Academy (Part 2 of 3).

    ERIC Educational Resources Information Center

    Petosa, Scott

    1989-01-01

    Discusses the evolution and structure of fitness programs for women at the U.S. Air Force Academy from 1977-87. Women's fitness level has continued to improve, although curriculum and physical fitness tests have remained the same for both sexes. (SM)

  19. Long sleep duration and afternoon napping are associated with higher risk of incident diabetes in middle-aged and older Chinese: the Dongfeng-Tongji cohort study.

    PubMed

    Han, Xu; Liu, Bing; Wang, Jing; Pan, An; Li, Yaru; Hu, Hua; Li, Xiulou; Yang, Kun; Yuan, Jing; Yao, Ping; Miao, Xiaoping; Wei, Sheng; Wang, Youjie; Liang, Yuan; Zhang, Xiaomin; Guo, Huan; Yang, Handong; Hu, Frank B; Wu, Tangchun; He, Meian

    2016-06-01

    Background In this study, we investigated the independent and combined effects of sleep duration and afternoon napping on the risk of incident diabetes among a cohort of middle-aged and older Chinese adults. Methods Information of sleep and napping was obtained by questionnaires during face-to-face interviews. We categorized sleep duration into <7 h, 7∼<8 h (reference), 8∼<9 h, 9∼<10 h, and ≥ 10 h. Afternoon napping was divided into no napping (0 min) (reference), 1-30 min, 31-60 min, 61-90 min, and > 90 min. Cox proportional hazard regression models were used. Results Compared with referential sleeping group, subjects sleeping ≥10 h had a 42% higher risk of developing diabetes. The HR was 1.28 for napping > 90 min when compared with no napping. These associations were more pronounced in individuals without hypertension. Combined effects of long sleep duration and afternoon napping were further identified. Individuals with both sleep duration ≥ 10 h and napping > 60 min had a 72% higher risk of incident diabetes than those with sleeping 7∼<8 h and napping 0 min (all above p < 0.05). Conclusions Both long sleep duration and afternoon napping were independently and jointly associated with higher risk of incident diabetes. Key messages Sleep duration was associated with diabetes, but whether it is a real cause of incident diabetes especially in Chinese still remains to be elucidated. The association of afternoon napping and diabetes was not consistent and definite, we clarified this association in a large prospective study. Long sleep duration and afternoon napping were independently and jointly associated with higher risk of incident diabetes. PMID:26969344

  20. [Spiritual ties of the Military Medical (Medical and Surgical) Academy].

    PubMed

    Gordienko, A V; Shamreĭ, V K

    2015-01-01

    Before the revolution in its educational, research and clinical potential of Military Medicine (medical and surgical) Academy was on the head position among European institutions. Not less outstanding position among all secular institutions Russian Academy held by the number and wealth of churches, chapels and baptisteries. In the temples of the academy was concentrated a significant number of miracle-working icons and of the particles holy relics, there served some of faith and piety devotees and some of them were canonized. The article presents a brief historical overview of the major Academy shrines--spiritual ties of the different generations. PMID:25916040

  1. Sex and experience in the academy award nomination process.

    PubMed

    Lincoln, Anne E

    2004-10-01

    Research has indicated significant age differences between male and female Academy Award nominees and winners. However, this discrepancy may be associated with sex differences in actors' ages when they first begin their acting careers. The present research uses event history analysis to investigate the duration of Academy Award nominees' careers from career start (first film) to first three Academy Award nominations. Analysis suggested controlling for an actor's age at first film explains the sex-age disparity between Academy Award nominees and winners. PMID:15587226

  2. Fusion/Astrophysics Teacher Research Academy

    NASA Astrophysics Data System (ADS)

    Correll, Donald

    2005-10-01

    In order to engage California high school science teachers in the area of plasma physics and fusion research, LLNL's Fusion Energy Program has partnered with the UC Davis Edward Teller Education Center, ETEC (http://etec.ucdavis.edu), the Stanford University Solar Center (http://solar-center.stanford.edu) and LLNL's Science / Technology Education Program, STEP (http://education.llnl.gov). A four-level ``Fusion & Astrophysics Research Academy'' has been designed to give teachers experience in conducting research using spectroscopy with their students. Spectroscopy, and its relationship to atomic physics and electromagnetism, provides for an ideal plasma `bridge' to the CA Science Education Standards (http://www.cde.ca.gov/be/st/ss/scphysics.asp). Teachers attend multiple-day professional development workshops to explore new research activities for use in the high school science classroom. A Level I, 3-day program consists of two days where teachers learn how plasma researchers use spectrometers followed by instructions on how to use a research grade spectrometer for their own investigations. A 3rd day includes touring LLNL's SSPX (http://www.mfescience.org/sspx/) facility to see spectrometry being used to measure plasma properties. Spectrometry classroom kits are made available for loaning to participating teachers. Level I workshop results (http://education.llnl.gov/fusion&_slash;astro/) will be presented along with plans being developed for Level II (one week advanced SKA's), Level III (pre-internship), and Level IV (summer internship) research academies.

  3. Gifted Education Press Quarterly, 1995.

    ERIC Educational Resources Information Center

    Fisher, Maurice D., Ed.

    1995-01-01

    This document consists of the four issues of the newsletter "Gifted Education Press Quarterly" published during 1995. This newsletter addresses issues in the education of gifted children and youth. The major articles are: (1) "Using Today's Technology: Parents Can Help Challenge Gifted Children" (Adrienne O'Neill); (2) "Outcomes-Based Education…

  4. Law and the Student Press.

    ERIC Educational Resources Information Center

    Stevens, George E.; Webster, John B.

    Court cases and legal decisions involving the student press in the late 1960s and early 1970s are brought together in this book in order to show how the law has been applied to school officials and student journalists in high school, college, and the underground. The ten chapters cover the following topics: censorship, libel, obscenity, contempt,…

  5. 30th Arniversary Press Conference

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Marking the occasion of the Apollo 11 30th Anniversary, members of the Apollo and Saturn astronaut programs attended festivities at Marshall Space Flight Center in Huntsville, AL. A press conference was held at the U. S. Space and Rocket Center for the visiting astronauts. Pictured are (L/R): Edgar Mitchell, Walt Cunningham, Charlie Duke, Buzz Aldrin, Dick Gordon and Owen Garriott.

  6. Inhibitory effects of rHP-NAP IgY against Helicobacter pylori attachment to AGS cell line.

    PubMed

    Borhani, Katayoun; Mohabati Mobarez, Ashraf; Khabiri, Ali Reza; Behmanesh, Mehrdad; Khoramabadi, Nima

    2016-08-01

    Helicobacter pylori is a major human pathogen related to gastric adenocarcinoma and gastroduodenal diseases. Treatment of H. pylori infections is complicated by the rise of antibiotic resistance, necessitating investigation of alternative therapies. One such alternative is passive immunization by oral administration of antibacterial immunoglobulin. In the present study, chicken immunoglobulin (IgY) was used for passive immunotherapy against a major virulence factor of H. pylori, namely recombinant HP-Nap protein. Recombinant HP-Nap was prepared and used to immunize hens. IgY was purified from the eggs by polyethylene glycol precipitation method with a total IgY-HP-NAP yield of 30 mg per egg. The inhibitory effect of specific IgY on H. pylori attachment was investigated in AGS cell line infected by the bacteria. The results demonstrate the potent effect of IgY- HP-NAP in inhibition of H. pylori attachment to the AGS cells. PMID:27265677

  7. Sleep and Behavioral Correlates of Napping among Young Adults: A Survey of First-Year University Students in Madrid, Spain

    ERIC Educational Resources Information Center

    Vela-Bueno, Antonio; Fernandez-Mendoza, Julio; Olavarrieta-Bernardino, Sara; Vgontzas, Alexandros N.; Bixler, Edward O.; de la Cruz-Troca, Juan Jose; Rodriguez-Munoz, Alfredo; Olivan-Palacios, Jesus

    2008-01-01

    Objective: Between November 2002 and March 2003, the authors assessed the prevalence and correlates of napping among Spanish university students. Participants: The sample comprised 1,276 first-year university students; the mean age was 18.74 [plus or minus] 1.24 years, and 35.45% were men. Methods: The study was cross-sectional, and the students…

  8. Optimizing sleep/wake schedules in space: Sleep during chronic nocturnal sleep restriction with and without diurnal naps

    NASA Astrophysics Data System (ADS)

    Mollicone, Daniel J.; Van Dongen, Hans P. A.; Dinges, David F.

    2007-02-01

    Effective sleep/wake schedules for space operations must balance severe time constraints with allocating sufficient time for sleep in order to sustain high levels of neurobehavioral performance. Developing such schedules requires knowledge about the relationship between scheduled "time in bed" (TIB) and actual physiological sleep obtained. A ground-based laboratory study in N=93 healthy adult subjects was conducted to investigate physiological sleep obtained in a range of restricted sleep schedules. Eighteen different conditions with restricted nocturnal anchor sleep, with and without diurnal naps, were examined in a response surface mapping paradigm. Sleep efficiency was found to be a function of total TIB per 24 h regardless of how the sleep was divided among nocturnal anchor sleep and diurnal nap sleep periods. The amounts of sleep stages 1+2 and REM showed more complex relationships with the durations of the anchor and nap sleep periods, while slow-wave sleep was essentially preserved among the different conditions of the experiment. The results of the study indicated that when sleep was chronically restricted, sleep duration was largely unaffected by whether the sleep was placed nocturnally or split between nocturnal anchor sleep periods and daytime naps. Having thus assessed that split-sleep schedules are feasible in terms of obtaining physiological sleep, further research will reveal whether these schedules and the associated variations in the distribution of sleep stages may be advantageous in mitigating neurobehavioral performance impairment in the face of limited time for sleep.

  9. NAP1-Assisted Nucleosome Assembly on DNA Measured in Real Time by Single-Molecule Magnetic Tweezers

    PubMed Central

    Vlijm, Rifka; Smitshuijzen, Jeremy S. J.; Lusser, Alexandra; Dekker, Cees

    2012-01-01

    While many proteins are involved in the assembly and (re)positioning of nucleosomes, the dynamics of protein-assisted nucleosome formation are not well understood. We study NAP1 (nucleosome assembly protein 1) assisted nucleosome formation at the single-molecule level using magnetic tweezers. This method allows to apply a well-defined stretching force and supercoiling density to a single DNA molecule, and to study in real time the change in linking number, stiffness and length of the DNA during nucleosome formation. We observe a decrease in end-to-end length when NAP1 and core histones (CH) are added to the dsDNA. We characterize the formation of complete nucleosomes by measuring the change in linking number of DNA, which is induced by the NAP1-assisted nucleosome assembly, and which does not occur for non-nucleosomal bound histones H3 and H4. By rotating the magnets, the supercoils formed upon nucleosome assembly are removed and the number of assembled nucleosomes can be counted. We find that the compaction of DNA at low force is about 56 nm per assembled nucleosome. The number of compaction steps and associated change in linking number indicate that NAP1-assisted nucleosome assembly is a two-step process. PMID:23050009

  10. The Role of Implied Motion in Engaging Audiences for Health Promotion: Encouraging Naps on a College Campus

    ERIC Educational Resources Information Center

    Mackert, Michael; Lazard, Allison; Guadagno, Marie; Hughes Wagner, Jessica

    2014-01-01

    Objective: Lack of sleep among college students negatively impacts health and academic outcomes. Building on research that implied motion imagery increases brain activity, this project tested visual design strategies to increase viewers' engagement with a health communication campaign promoting napping to improve sleep habits. Participants:…

  11. DOD Service Academies: More Changes Needed To Eliminate Hazing. Report to Congressional Requesters.

    ERIC Educational Resources Information Center

    General Accounting Office, Washington, DC. Div. of National Security and International Affairs.

    This study sought to review the extent of hazing at the three Department of Defense (DOD) service academies, the actions taken by the academies to control and eliminate hazing, and the impact of hazing on cadets and midshipmen. The three academies studied were the Naval Academy (Annapolis, Maryland), the Air Force Academy (Colorado Springs,…

  12. USAF Academy Center for Space Situational Awareness

    NASA Astrophysics Data System (ADS)

    Dearborn, M.; Chun, F.; Liu, J.; Tippets, R.

    2011-09-01

    Since the days of Sputnik, the Air Force has maintained the surveillance of space and a position catalog of objects that can be tracked by primarily ground-based radars and optical systems. Recent events in space such as the test of the Chinese anti-satellite weapon in 2007 and the collision between an Iridium and Russian Cosmo satellite have demonstrated the great need to have a more comprehensive awareness of the situation in space. Hence space situational awareness (SSA) has become an increasingly important mission to the Air Force and to the security of the United States. To help meet the need for future leaders knowledgeable about SSA, the Air Force Academy formally stood up the Center for Space Situational Awareness (CSSAR). The goal of the CSSAR is to provide a unique combination of educational operational experience as well as a world-class research capability for hands-on education in SSA. In order to meet this goal, the CSSAR is implementing an array of sensors, operations center, and associated software, and analysis tools. For example we have radar receivers for bi-static returns from the VHF space fence, a network of small aperture telescopes, AFSPC astro standards software, and Joint Mission System software. This paper focuses on the observational capabilities of our telescopes. In general, the preferable method for characterizing a satellite is to obtain a high-resolution image. However, high-resolution images from groundbased telescopes are only achievable if the satellite is large and close in range. Thus small satellites in low-earth orbits and large satellites in geosynchronous orbits are essentially unresolved in the focal plane of a ground-based telescope. Building ever larger telescopes capable of tracking fast enough for satellites at high resolution requires tremendous resources and funding. Cost is one of the reasons we decided to develop a network of small, commercially available telescopes spatially diverse and networked together. We call

  13. Long-Term Single and Joint Effects of Excessive Daytime Napping on the HOMA-IR Index and Glycosylated Hemoglobin

    PubMed Central

    Li, Xue; Pang, Xiuyu; Zhang, Qiao; Qu, Qiannuo; Hou, Zhigang; Liu, Zhipeng; Lv, Lin; Na, Guanqiong; Zhang, Wei; Sun, Changhao; Li, Ying

    2016-01-01

    Abstract This prospective cohort study was conducted to assess the duration of daytime napping and its effect combined with night sleep deprivation on the risk of developing high HOMA-IR (homeostasis model assessment of insulin resistance) index and disadvantageous changes in glycosylated hemoglobin (HbA1c) levels. A total of 5845 diabetes-free subjects (2736 women and 3109 men), 30 to 65 years of age, were targeted for this cohort study since 2008. Multiple adjusted Cox regression models were performed to evaluate the single and joint effects of daytime napping on the risk of an elevated HbA1c level and high HOMA-IR index. After an average of 4.5 years of follow-up, >30 minutes of daytime napping was significantly associated with an increased risk of an elevated HbA1c level (>6.5%) in men and women (all P trend < 0.05). Hazard ratios (HRs) for an HbA1c level between 5.7% and 6.4% were also significant in the entire cohort and women, but nonsignificant in men. HRs (95% confidence interval, CIs) for the high HOMA-IR index in the entire cohort, men, and women were 1.33 (1.10–1.62), 1.46 (1.08–1.98), and 1.47 (1.12–1.91), respectively. The combination of sleep deprivation with no naps or >30 minutes napping and the combination of no sleep deprivation with >30 minutes daytime napping were all associated with an HbA1c level >6.5% (HR = 2.08, 95% CI = 1.24–3.51; HR = 4.00, 95% CI = 2.03–7.90; and HR = 2.05, 95% CI = 1.29–3.27, respectively). No sleep deprivation combined with >30 minutes daytime napping correlated with a high risk of an HbA1c level between 5.7% and 6.4% and high HOMA-IR index (HR = 2.12, 95% CI = 1.48–3.02; and HR = 1.35, 95% CI = 1.10–1.65, respectively). Daytime napping >30 minutes was associated with a high risk of an elevated HbA1c level and high HOMA-IR index. No sleep deprivation combined with napping >30 minutes carries a risk of abnormal glucose metabolism. Sleep deprivation combined with

  14. Napping-Ultra Flash Profile as a Tool for Category Identification and Subsequent Model System Formulation of Caramel Corn Products.

    PubMed

    Mayhew, Emily; Schmidt, Shelly; Lee, Soo-Yeun

    2016-07-01

    In a novel approach to formulation, the flash descriptive profiling technique Napping-Ultra Flash Profile (Napping-UFP) was used to characterize a wide range of commercial caramel corn products. The objectives were to identify product categories, develop model systems based on product categories, and correlate analytical parameters with sensory terms generated through the Napping-UFP exercise. In one 2 h session, 12 panelists participated in 4 Napping-UFP exercises, describing and grouping, on a 43×56 cm paper sheet, 12 commercial caramel corn samples by degree of similarity, globally and in terms of aroma-by-mouth, texture, and taste. The coordinates of each sample's placement on the paper sheet and descriptive terms generated by the panelists were used to conduct Multiple Factor Analysis (MFA) and hierarchical clustering of the samples. Strong trends in the clustering of samples across the 4 Napping-UFP exercises resulted in the determination of 3 overarching types of commercial caramel corn: "small-scale dark" (typified by burnt, rich caramel corn), "large-scale light" (typified by light and buttery caramel corn), and "large-scale dark" (typified by sweet and molasses-like caramel corn). Representative samples that best exemplified the properties of each category were used as guides in the formulation of 3 model systems that represent the spread of commercial caramel corn products. Analytical testing of the commercial products, including aw measurement, moisture content determination, and thermal characterization via differential scanning calorimetry, were conducted and results related to sensory descriptors using Spearman's correlation. PMID:27249670

  15. Optimal guidance with obstacle avoidance for nap-of-the-earth flight

    NASA Technical Reports Server (NTRS)

    Pekelsma, Nicholas J.

    1988-01-01

    The development of automatic guidance is discussed for helicopter Nap-of-the-Earth (NOE) and near-NOE flight. It deals with algorithm refinements relating to automated real-time flight path planning and to mission planning. With regard to path planning, it relates rotorcraft trajectory characteristics to the NOE computation scheme and addresses real-time computing issues and both ride quality issues and pilot-vehicle interfaces. The automated mission planning algorithm refinements include route optimization, automatic waypoint generation, interactive applications, and provisions for integrating the results into the real-time path planning software. A microcomputer based mission planning workstation was developed and is described. Further, the application of Defense Mapping Agency (DMA) digital terrain to both the mission planning workstation and to automatic guidance is both discussed and illustrated.

  16. Directional handling qualities requirements for nap of the earth (NOE) tasks

    NASA Technical Reports Server (NTRS)

    Bivens, C. C.

    1985-01-01

    A piloted simulator experiment has been conducted to ascertain the directional axis handling requirements of hover and below 40-kt tasks of a scout/attack helicopter, with attention to such light helicopter configurations as those being considered for the 'LHX' program. Two types of yaw stability and control augmentation system were implemented: one consisted of a washed-out yaw rate feedback and shaped control unit, while the other involved a yaw rate command heading-hold system. Experiment results indicate that rotorcraft configurations with high directional gust sensitivity require greater minimum yaw damping to maintain satisfactory handling qualities in nap of the earth flight. Yaw damping and control response are critical handling qualities parameters in air-to-air target acquisition and tracking.

  17. A laser image generation system for helicopter Nap-Of-the-Earth (NOE) flight training

    NASA Astrophysics Data System (ADS)

    Tong, H. M.

    1983-11-01

    The training effectiveness of the camera-modelboard visual system for low-altitude, nap-of-the-earth (NOE) flights, particularly for helicopters, is well established. Traditional camera-modelboard technology, however, has a number of inherent limitations which have been overcome by using a laser image generator instead of a TV camera as in the current generation of camera-modelboard systems. The first full-scale Laser Image Generation (LIG) visual system, developed by Singer-Link under the AH-lS Cobra Helicopter Flight Weapons Simulator contract, will be delivered to the U.S. Army in the near future. This new visual system offers improvements in many areas, some of which are discussed in this paper, together with the visual system technology involved and performance parameters achieved on the AH-lS simulator.

  18. Academy issues report on Yucca Mountain

    NASA Astrophysics Data System (ADS)

    Bush, Susan

    The National Academy of Sciences released a report on April 13 concluding that Yucca Mountain, the proposed nuclear waste repository site located about 100 miles northwest of Las Vegas, Nev., is not at risk from groundwater infiltration. “There is no evidence to support the assertion that the water table has risen periodically hundreds of meters from deep within the crust,” the report states.According to vice chairman of the NAS panel George A. Thompson of Stanford University, the panel was charged with evaluating whether the water table has risen in the past to the level of the proposed repository or if this might happen in the future. The panel was not responsible for determining whether Yucca Mountain is suitable as a repository site.

  19. Science, Engineering, Mathematics and Aerospace Academy

    NASA Technical Reports Server (NTRS)

    1997-01-01

    This is an annual report on the Science, Engineering, Mathematics, and Aerospace Academy (SEMAA), which is run as a collaborative effort of NASA Lewis Research Center, and Cuyahgoga Community College. The purpose of SEMA is to increase the percentage of African Americans, and Hispanics in the fields of science and technology. The SEMAA program reaches from kindergarden, to grade 12, involving the family of under-served minorities in the education of the children. The year being reported (i.e., 1996-1997) saw considerable achievement. The program served over 1,939 students, and 120 parents were involved in various seminars. The report goes on to review the program and its implementation for each grade level. It also summarizes the participation, by gender and ethnicity.

  20. Science, Engineering, Mathematics and Aerospace Academy

    NASA Technical Reports Server (NTRS)

    1996-01-01

    The Science, Engineering, Mathematics and Aerospace Academy (SEMAA) was established in September, 1993, by Cuyahoga Community College and the NASA Lewis Research Center. Funding for SEMAA was provided by NASA Headquarters' Office of Equal Employment Opportunities. SEMAA brought together five preexisting youth programs at Cuyahoga Community College. All the programs shared the common goals of 1) Increasing the participation of underrepresented/underserved groups in science, mathematics and engineering and technology careers. 2) Increasing "success" rates of all students interested in science and mathematics. 3) Developing partnerships to recognize and support students interested in these fields. 4) Supporting continued success of highly successful students. The framework for each preexisting program allowed SEMAA to have a student population ranging from kindergarten through the twelfth-grade. This connectivness was the foundation for the many decisions which would make SEMAA a truly innovative program.

  1. Parents in the Admission Process: A Service Academy's Perspective.

    ERIC Educational Resources Information Center

    Combs, Thomas D., Jr.

    1986-01-01

    Service academies have found that parental influence is a significant factor in the application and selection processes. Project Outreach of the Coast Guard Academy, a parent-to-parent contact using volunteers supervised by the Admissions Office, represents a way of showing concern regarding each student's uniqueness and of constructively…

  2. Boot Camp for Education CEOs: The Broad Foundation Superintendents Academy

    ERIC Educational Resources Information Center

    Jehlen, Alain

    2012-01-01

    The Broad Foundation Superintendents Academy is the most prominent and most controversial training institute for school chiefs. The Academy is the flagship program of the Eli and Edythe Broad Foundation, the smallest of a triumvirate of corporate foundations that are at the heart of the billionaire campaign to remake public education in the image…

  3. Diversity of Service Academy Entrants and Graduates. Monograph

    ERIC Educational Resources Information Center

    Kirby, Sheila Nataraj; Thie, Harry J.; Naftel, Scott; Adelson, Marisa

    2010-01-01

    In the wake of concern about the diversity of cadets/midshipmen selected by the service academies, Congress requested that the Secretary of Defense conduct a comprehensive assessment of the recruiting efforts, admissions policies, graduation rates, and career success rates of entrants and graduates at the United States Military Academy (USMA), the…

  4. Implementing Career Academies Schoolwide: 2001-2002 Developments, Promising Practices.

    ERIC Educational Resources Information Center

    Stern, David; Dayton, Charles; Lenz, Robert; Tidyman, Susan

    This document, which is based on the findings of case studies of how four high schools from across the country have successfully implemented the schoolwide career academy model, presents recent developments and best practices in schoolwide career academies. The document consists of a brief introduction describing the case studies and one chapter…

  5. Academies and Maintained Schools: What Do We Know? Election Factsheet

    ERIC Educational Resources Information Center

    Gee, Geoff; Worth, Jack; Sims, David

    2015-01-01

    This election factsheet highlights the following points: (1) Academies receive their funding directly from the government, rather than through local authorities like other state funded schools; (2) There are two types: converter academies (those previously with "good" or "outstanding" Ofsted grades that have converted to…

  6. Teachers' Experiences with the Transition to a Career Academy

    ERIC Educational Resources Information Center

    Spurlock, Charlene Denise

    2010-01-01

    Career academies, schools within schools that concentrate on career fields, require the intentional efforts of teachers working collaboratively and sharing best practices to increase students' achievement and employability. Little is known of the perceptions of career academies' teachers, however, as they attempt to make changes in practice. The…

  7. Academic Integrity at the United States Air Force Academy

    ERIC Educational Resources Information Center

    Derby, LeAnn

    2006-01-01

    In troubled times, where threats to honor abound, it is essential that people support students who may have been enculturated in social dishonesty. The United States Air Force Academy (USAFA) has worked hard to put in place a number of supports to help cadets to grow beyond social norms where dishonesty may be tolerated. The academy seeks to…

  8. The Academy and the Engineering Sciences: An Unwelcome Royal Gift

    ERIC Educational Resources Information Center

    Konig, Wolfgang

    2004-01-01

    On 19 March 1900, at the bicentenary celebrations of the Prussian Academy of Sciences, Kaiser Wilhelm II established three new fellowships in engineering sciences. This was in many aspects an unwanted gift, and one which tested the Academy's relationship between pure and applied science. In the context of contemporary struggles between traditional…

  9. Predictors of Student Enrollment Patterns in High School Career Academies

    ERIC Educational Resources Information Center

    Cox, E. Daniel

    2013-01-01

    The purpose of this study was to describe participation patterns at the district level of students enrolled in career academies and determine whether participation in career academies is a function of demographic and/or prior learning experience and prior performance variables. Ex-post facto data was used to determine six-year enrollment trends.…

  10. The Indiana Principal Leadership Academy: A Model for Professional Development.

    ERIC Educational Resources Information Center

    Ellsberry, James; And Others

    In response to the need for professional growth opportunities for principals, the Indiana Principal Leadership Academy (IPLA) was founded in 1985. The IPLA was created to be a national training model for principals, as leaders of instructors, empowered with effective behaviors and practices. The academy's focus is on four proficiencies: (1)…

  11. Evolution of a Planetary System. SETI Academy Planet Project.

    ERIC Educational Resources Information Center

    Search for Extraterrestrial Intelligence Inst., Mountain View, CA.

    The SETI Academy Planet Project provides an exciting, informative, and creative series of activities for elementary students (grades 5-6) in these activities each student plays the role of a cadet at the SETI Academy, a fictitious institution. This unit examines the evolution of stars and planets which is an important aspect of the search for…

  12. Vocational Education in the 19th Century American Academy.

    ERIC Educational Resources Information Center

    Law, Gordon F.

    The phrase "all things useful and all things ornamental," coined by Benjamin Franklin, describes the stated mission of most of the approximately 6,000 educational academies flourishing in America in the mid-19th century. Built upon the roots of Latin grammar schools, the academies evolved to include courses in many areas, from classical studies to…

  13. Visible Leading: Principal Academy Connects and Empowers Principals

    ERIC Educational Resources Information Center

    Hindman, Jennifer; Rozzelle, Jan; Ball, Rachel; Fahey, John

    2015-01-01

    The School-University Research Network (SURN) Principal Academy at the College of William & Mary in Williamsburg, Virginia, has a mission to build a leadership development program that increases principals' instructional knowledge and develops mentor principals to sustain the program. The academy is designed to connect and empower principals…

  14. A Program Evaluation of a Leadership Academy for School Principals

    ERIC Educational Resources Information Center

    Wagner, Kristi E.

    2014-01-01

    This program evaluation focused on mid-range outcomes of a leadership academy for school principals. The mixed-methods evaluation included interviews, principals' instructional observation database, and teacher surveys. The Principal Academy program was designed to build principals' knowledge of high-yield instructional strategies (Hattie, 2009),…

  15. Academies in Context: Politics, Business and Philanthropy and Heterarchical Governance

    ERIC Educational Resources Information Center

    Ball, Stephen J.

    2009-01-01

    The English Academies programme has become one of the most controversial aspects of the New Labour strategy for education and public sector reform. And in many ways, given the significance of the programme, that controversy is understandable and appropriate. This is particularly so because, as the author argues here, Academies are indicative of…

  16. Academy of READING®. What Works Clearinghouse Intervention Report

    ERIC Educational Resources Information Center

    What Works Clearinghouse, 2014

    2014-01-01

    "Academy of READING"® is an online program that aims to improve students' reading skills using a structured and sequential approach to learning in five core areas--phonemic awareness, phonics, fluency, vocabulary, and comprehension. The What Works Clearinghouse (WWC) identified 38 studies of "Academy of READING"® for…

  17. The Academy Promotes, Unifies, and Evaluates Doctoral Education in Kinesiology

    ERIC Educational Resources Information Center

    Thomas, Jerry R.; Clark, Jane E.; Feltz, Deborah L.; Kretchmar, R. Scott; Morrow, James R., Jr.; Reeve, T. Gilmour; Wade, Michael G.

    2007-01-01

    This paper provides a description and documentation of two significant events in the history of our field: (1) the development of our field and the doctoral program review process and outcome by the American Academy of Kinesiology and Physical Education; and (2) the process by which the Academy successfully had "kinesiology" included as a…

  18. OnTheMove Academy 2009 Organizers' Message

    NASA Astrophysics Data System (ADS)

    Spyns, Peter; Schanzenberger, Anja

    We are very happy to re-establish the tradition of organizing what is now called the OTM Academy, the workshop for coaching PhD students with promising work. The term "academy," originating from Greek antiquity, implies a strong mark of quality and excellence that is upheld and promoted by its members.

  19. Neither Athens Nor Sparta? The American Service Academies in Transition.

    ERIC Educational Resources Information Center

    Lovell, John P.

    The images, realities, and transitions of the American service academies are examined in this book. The contradictions between the classical Athens emphasis on well-educated and cultured individuals, and the Spartan emphasis on discipline, physical prowess, courage, and honor that have been inherent in the academies are brought to task. The…

  20. Ethos and Vision Realization in Sponsored Academy Schools

    ERIC Educational Resources Information Center

    Gibson, Mark T.

    2015-01-01

    This article investigates the realization of ethos and vision in the early stages of sponsored academy schools in England. It is a qualitative nested case study of ten academies. Nineteen key actors were interviewed, including principals and sponsor representatives. The nests were organized by sponsor type. Key themes are discussed within the…

  1. Career Academy Programs in California: Outcomes and Implementation. CPRC Report.

    ERIC Educational Resources Information Center

    Maxwell, Nan L.; Rubin, Victor

    The outcomes and implementation of career academy programs in California were examined in a study of one school district's efforts to implement a uniform career academy model in 1990-1996. A cohort of approximately 10,000 students who were sophomores in the district's comprehensive high schools between 1990 and 1993 were followed through high…

  2. Morning REM Sleep Naps Facilitate Broad Access to Emotional Semantic Networks

    PubMed Central

    Carr, Michelle; Nielsen, Tore

    2015-01-01

    Study Objectives: The goals of the study were to assess semantic priming to emotion and nonemotion cue words using a novel measure of associational breadth for participants who either took rapid eye movement (REM) or nonrapid eye movement (NREM) naps or who remained awake, and to assess the relation of priming to REM sleep consolidation and REM sleep inertia effects. Design: The associational breadth task was applied in both a priming condition, where cue words were signaled to be memorized prior to sleep (primed), and a nonpriming condition, where cue words were not memorized (nonprimed). Cue words were either emotional (positive, negative) or nonemotional. Participants were randomly assigned to either an awake (WAKE) or a sleep condition, which was subsequently split into NREM or REM groups depending on stage at awakening. Setting: Hospital-based sleep laboratory. Participants: Fifty-eight healthy participants (22 male) ages 18 to 35 y (mean age = 23.3 ± 4.08 y). Measurements and Results: The REM group scored higher than the NREM or WAKE groups on primed, but not nonprimed emotional cue words; the effect was stronger for positive than for negative cue words. However, REM time and percent correlated negatively with degree of emotional priming. Priming occurred for REM awakenings but not for NREM awakenings, even when the latter sleep episodes contained some REM sleep. Conclusions: Associational breadth may be selectively consolidated during REM sleep for stimuli that have been tagged as important for future memory retrieval. That priming decreased with REM time and was higher only for REM sleep awakenings is consistent with two explanatory REM sleep processes: REM sleep consolidation serving emotional downregulation and REM sleep inertia. Citation: Carr M, Nielsen T. Morning REM sleep naps facilitate broad access to emotional semantic networks. SLEEP 2015;38(3):433–443. PMID:25409100

  3. Hot isostatic pressing of ceramics

    NASA Technical Reports Server (NTRS)

    Honma, K.

    1985-01-01

    A mixture containing glass 70 to 95 and BN or B4C powder (0.1-10 microns) 5 to 30 vol. % is used as a secondary pressure medium in hot isostatic pressing of ceramics. Thus, Pyrex beads were mixed with 15% vol. BN powder (average diameter 2 microns), fused at 1400 deg for 2 h, cooled, crushed, and put into a graphite crucible. A Si3N4 sintered body was embedded in the powder, heated in vacuum at 1200 deg for 2 h, treated in a hot isostatic press furnace at 1700 deg and 1000 atm. for 1 h, and cooled to give a Si3N4 ceramic. It was easily separated from the crucible.

  4. [The contribution of the Military Medical Academy to space exploration].

    PubMed

    Belevitin, A B; Tsygan, V N; Blaginin, A A; Kaltygin, M V

    2011-04-01

    The article examines the contribution of the Military Medical Academy as an educational, research and medical institutions in the establishment and development of the national Russian manned spaceflight. Lists the names of the Academy's scientists, working in laboratories and in the Cosmonaut Training Center. In 1958 the academy was formed Department of Aviation Medicine from the research laboratories of aviation medicine, psychophysiology, and encephalography, a division of pressure chambers and furnaces. Direct contribution to the preparation of the first manned space flight made by graduates of the academy, E.A. Karpov (the first chief of Cosmonauts Training Center. Yuri Gagarin) and I.A. Kolosov. Over the half century history of the Russian Space Military Medical Academy, prepared and sent to the CPC Gagarin more than 110 of its graduates. PMID:21770320

  5. A Conversation with Frank Press

    NASA Astrophysics Data System (ADS)

    Goodstein, Judith R.

    Geophysicist Frank Press was director of Caltech's Seismological Laboratory from 1957 to 1965. In this interview, he recalls his work with Maurice Ewing at Columbia's Lamont Geological Observatory; his directorship of Caltech's Seismological Laboratory and colleagues Charles Richter, Beno Gutenberg, and Hugo Benioff; his work on the free oscillations of the earth; and his part in establishing the worldwide network of seismographs for the detection of nuclear weapons testing.

  6. Radial Electromagnetic Press for IGNITOR

    NASA Astrophysics Data System (ADS)

    Cucchiaro, A.; Anzidei, L.; Capriccioli, A.; Celentano, G.; Crescenzi, C.; Gasparotto, M.; Guerrieri, A.; Pizzuto, A.; Palmieri, A.; Rita, C.; Roccella, M.; Coppi, B.

    1998-11-01

    The structural performance of the IGNITOR machine relies upon a combination of both bucking between Toroidal Field Coils (TFCs), Central Solenoid (CS) and the Central Post (CP), and wedging in a well-defined area of the TFCs and of the magnet mechanical structure (called C-Clamps). This requires a pre-loading system to enhance the load bearing capability. Several solutions have been assessed and compared with each other within the operational scenarios and eventually a radial electromagnetic press has been selected as reference(Pizzuto A. et al., ENEA Report IGN/MAC/001/96). The loading system is made up by active coils and passive restraining rings. The radial active press consists of two pairs of coils (200x200mm each), symmetrically located relative to the machine equatorial plane and seating onto the passive rings. The permanent pre--load of the rings is applied through a wedging system with a load of about 120 MN. A radial electromagnetic press has the purpose of modulating the axial pressure on the TFC inner legs during the pulse. Design aspects including stress analysis, manufacturing, assembly and operational scenarios of the selected solution are presented in this paper.

  7. The Small Book Press: A Cultural Essential.

    ERIC Educational Resources Information Center

    Henderson, Bill

    1984-01-01

    Discussion of small literary book publishers notes works of small-press authors (Thomas Paine, Washington Irving, Walt Whitman, Mark Twain, Upton Sinclair, Anais Nin); today's outstanding presses (Creative Arts Book Company, Persea Books, Full Court Press, Reed and Cannon Company, Tuumba Books); and role of little magazines. Thirty-seven…

  8. Yale University Press: Disseminating "Lux et Veritas"?

    ERIC Educational Resources Information Center

    Parrott, John B.

    2010-01-01

    America's university presses are situated within a network of over one hundred universities, learned societies, and scholarly associations. According to a pamphlet put out by the American Association of University Presses, these presses "make available to the broader public the full range and value of research generated by university faculty."…

  9. The Burger Court and the Press.

    ERIC Educational Resources Information Center

    Higdon, Philip R.

    This report discusses recent cases involving freedom of the press that have been heard before the Burger court of the United States Supreme Court. The report discerns a trend toward treating the press like an ordinary citizen; this is a reversal of the view of the Warren court that the First Amendment creates special rights for the press so that…

  10. The Assistant Principals' Academy: Technical Training and Socialization of Future Leaders.

    ERIC Educational Resources Information Center

    Peterson, Kent D.; And Others

    1987-01-01

    Assistant principal academies provide rigorous training for future administrators. Discusses the organizational frameworks and opportunities and hazards of such academies. Provides a description of the first academy held in McDowell County, North Carolina. Includes references. (MD)

  11. National Academy of Sciences Recommends Continued Support of ALMA Project

    NASA Astrophysics Data System (ADS)

    2000-05-01

    A distinguished panel of scientists today announced their support for the continued funding of the Atacama Large Millimeter Array (ALMA) Project at a press conference given by the National Academy of Sciences. The ALMA Project is an international partnership between U.S. and European astronomy organizations to build a complete imaging telescope that will produce astronomical images at millimeter and submillimeter wavelengths. The U.S. partner is the National Science Foundation, through Associated Universities, Inc., (AUI), led by Dr. Riccardo Giacconi, and the National Radio Astronomy Observatory (NRAO). "We are delighted at this show of continued support from our peers in the scientific community," said Dr. Robert Brown, ALMA U.S. Project Director and Deputy Director of NRAO. "The endorsement adds momentum to the recent strides we've made toward the building of this important telescope." In 1998, the National Research Council, the working arm of the National Academy of Sciences, charged the Astronomy and Astrophysics Survey Committee to "survey the field of space- and ground-based astronomy and astrophysics" and to "recommend priorities for the most important new initiatives of the decade 2000-2010." In a report released today, the committee wrote that it "re-affirms the recommendations of the 1991 Astronomy and Astrophysics Survey Committee by endorsing the completion of . . . the Millimeter Array (MMA, now part of the Atacama Large Millimeter Array)." In the 1991 report "The Decade of Discovery," a previous committee chose the Millimeter Array as one of the most important projects of the decade 1990-2000. Early last year, the National Science Foundation signed a Memorandum of Understanding with a consortium of European organizations that effectively merged the MMA Project with the European Large Southern Array project. The combined project was christened the Atacama Large Millimeter Array. ALMA, expected to consist of 64 antennas with 12-meter diameter dishes

  12. [The Academy of Ideas - second edition 2014].

    PubMed

    2014-01-01

    The Academy of Ideas is an initiative of the Italian Society of Nephrology, dedicated to young people who work in nephrology. The 2014 edition wants to foster innovative ideas at different levels of maturity along the research and innovation process, through two distinct sections meant for people who present basic or applied research ideas and for people who submit proofs of concepts transferable to products or services in a relatively short time period. The proposal aims to enhance grant application skills, giving to young researchers the opportunity of collaborating with multi-disciplinary groups of professionals; help young researchers to exploit ideas arising from clinical research and showing a Technology Readiness Level that allows immediate or close in time applicability; foster the understanding of the business perspective in the nephrology sector: giving to young scientists the opportunity to have in-hand experience on challenges related to bringing to the market research results; create a network of knowledge and collaboration among young researchers to facilitate the establishment of collaborative relationships and promote the creation of new projects and publications of high scientific impact. PMID:24945044

  13. Khan Academy: the world's free virtual school

    NASA Astrophysics Data System (ADS)

    Dijksman, Joshua A.; Khan, Salman

    2011-03-01

    Khan Academy offers an unprecedented set of educational material for science and math education, in the form of short, free, publicly available video clips. With a growing set of already over 2000 videos, it is easily the most exhaustive collection of structured educational material on the Internet. The content is made in digestible 10-20 minute chunks; the granular nature of the material allows learners to fill in almost any of their knowledge ``gaps.'' Importantly, the conversational style used in the videos offers a fresh, new perspective on math and science instruction. With our 2 M funding grant from Google and support from the Gates foundation, we envision covering all topics that would appear in typical high-school or collegiate-level Math and Science courses, and translating these videos to the major languages across the globe. Moreover, we also offer a free and fully integrated assessment system, which allows students to practice problems at their own pace and focus on the appropriate instruction to fill in their individual gaps. Many testimonials have already proven our methods to be a highly successful educational tool. Our goal is to allow educators to improve their teaching, but above all to bring simple, rewarding and enjoyable education to the minds of many young students. Supported by Google, the Gates Foundation, donors and volunteers.

  14. Van Allen Probes Mission Space Academy: Educating middle school students about Earth's mysterious radiation belts

    NASA Astrophysics Data System (ADS)

    Butler, L.; Turney, D.; Matiella Novak, A.; Smith, D.; Simon, M.

    2013-12-01

    How's the weather in space? Why on Earth did NASA send two satellites above Earth to study radiation belts and space weather? To learn the answer to questions about NASA's Van Allen Probes mission, 450 students and their teachers from Maryland middle schools attended Space Academy events highlighting the Van Allen Probes mission. Sponsored by the Applied Physics Laboratory (APL) and Discovery Education, the events are held at the APL campus in Laurel, MD. Space Academies take students and teachers on behind-the-scenes exploration of how spacecraft are built, what they are designed to study, and introduces them to the many professionals that work together to create some of NASA's most exciting projects. Moderated by a public relations representative in the format of an official NASA press conference, the daylong event includes a student press conference with students as reporters and mission experts as panelists. Lunch with mission team members gives students a chance to ask more questions. After lunch, students don souvenir clean room suits, enjoy interactive science demonstrations, and tour APL facilities where the Van Allen Probes were built and tested before launch. Students may even have an opportunity to peek inside a clean room to view spacecraft being assembled. Prior to the event, teachers are provided with classroom activities, lesson plans, and videos developed by APL and Discovery Education to help prepare students for the featured mission. The activities are aligned to National Science Education Standards and appropriate for use in the classroom. Following their visit, student journalists are encouraged to write a short article about their field trip; selections are posted on the Space Academy web site. Designed to engage, inspire, and influence attitudes about space science and STEM careers, Space Academies provide an opportunity to attract underserved populations and emphasize that space science is for everyone. Exposing students to a diverse group of

  15. The Molybdate-Responsive Escherichia coli ModE Transcriptional Regulator Coordinates Periplasmic Nitrate Reductase (napFDAGHBC) Operon Expression with Nitrate and Molybdate Availability

    PubMed Central

    McNicholas, Paul M.; Gunsalus, Robert P.

    2002-01-01

    Expression of the Escherichia coli napFDAGHBC operon (also known as aeg46.5), which encodes the periplasmic molybdoenzyme for nitrate reduction, is increased in response to anaerobiosis and further stimulated by the addition of nitrate or to a lesser extent by nitrite to the cell culture medium. These changes are mediated by the transcription factors Fnr and NarP, respectively. Utilizing a napF-lacZ operon fusion, we demonstrate that napF gene expression is impaired in strain defective for the molybdate-responsive ModE transcription factor. This control abrogates nitrate- or nitrite-dependent induction during anaerobiosis. Gel shift and DNase I footprinting analyses establish that ModE binds to the napF promoter with an apparent Kd of about 35 nM at a position centered at −133.5 relative to the start of napF transcription. Although the ModE binding site sequence is similar to other E. coli ModE binding sites, the location is atypical, because it is not centered near the start of transcription. Introduction of point mutations in the ModE recognition site severely reduced or abolished ModE binding in vitro and conferred a modE phenotype (i.e., loss of molybdate-responsive gene expression) in vivo. In contrast, deletion of the upstream ModE region site rendered napF expression independent of modE. These findings indicate the involvement of an additional transcription factor to help coordinate nitrate- and molybdate-dependent napF expression by the Fnr, NarP, NarL, and ModE proteins. The upstream ModE regulatory site functions to override nitrate control of napF gene expression when the essential enzyme component, molybdate, is limiting in the cell environment. PMID:12029041

  16. C-Nap1 mutation affects centriole cohesion and is associated with a Seckel-like syndrome in cattle

    PubMed Central

    Floriot, Sandrine; Vesque, Christine; Rodriguez, Sabrina; Bourgain-Guglielmetti, Florence; Karaiskou, Anthi; Gautier, Mathieu; Duchesne, Amandine; Barbey, Sarah; Fritz, Sébastien; Vasilescu, Alexandre; Bertaud, Maud; Moudjou, Mohammed; Halliez, Sophie; Cormier-Daire, Valérie; E.L. Hokayem, Joyce; Nigg, Erich A.; Manciaux, Luc; Guatteo, Raphaël; Cesbron, Nora; Toutirais, Geraldine; Eggen, André; Schneider-Maunoury, Sylvie; Boichard, Didier; Sobczak-Thépot, Joelle; Schibler, Laurent

    2015-01-01

    Caprine-like Generalized Hypoplasia Syndrome (SHGC) is an autosomal-recessive disorder in Montbéliarde cattle. Affected animals present a wide range of clinical features that include the following: delayed development with low birth weight, hind limb muscular hypoplasia, caprine-like thin head and partial coat depigmentation. Here we show that SHGC is caused by a truncating mutation in the CEP250 gene that encodes the centrosomal protein C-Nap1. This mutation results in centrosome splitting, which neither affects centriole ultrastructure and duplication in dividing cells nor centriole function in cilium assembly and mitotic spindle organization. Loss of C-Nap1-mediated centriole cohesion leads to an altered cell migration phenotype. This discovery extends the range of loci that constitute the spectrum of autosomal primary recessive microcephaly (MCPH) and Seckel-like syndromes. PMID:25902731

  17. C-Nap1 mutation affects centriole cohesion and is associated with a Seckel-like syndrome in cattle.

    PubMed

    Floriot, Sandrine; Vesque, Christine; Rodriguez, Sabrina; Bourgain-Guglielmetti, Florence; Karaiskou, Anthi; Gautier, Mathieu; Duchesne, Amandine; Barbey, Sarah; Fritz, Sébastien; Vasilescu, Alexandre; Bertaud, Maud; Moudjou, Mohammed; Halliez, Sophie; Cormier-Daire, Valérie; Hokayem, Joyce E L; Nigg, Erich A; Manciaux, Luc; Guatteo, Raphaël; Cesbron, Nora; Toutirais, Geraldine; Eggen, André; Schneider-Maunoury, Sylvie; Boichard, Didier; Sobczak-Thépot, Joelle; Schibler, Laurent

    2015-01-01

    Caprine-like Generalized Hypoplasia Syndrome (SHGC) is an autosomal-recessive disorder in Montbéliarde cattle. Affected animals present a wide range of clinical features that include the following: delayed development with low birth weight, hind limb muscular hypoplasia, caprine-like thin head and partial coat depigmentation. Here we show that SHGC is caused by a truncating mutation in the CEP250 gene that encodes the centrosomal protein C-Nap1. This mutation results in centrosome splitting, which neither affects centriole ultrastructure and duplication in dividing cells nor centriole function in cilium assembly and mitotic spindle organization. Loss of C-Nap1-mediated centriole cohesion leads to an altered cell migration phenotype. This discovery extends the range of loci that constitute the spectrum of autosomal primary recessive microcephaly (MCPH) and Seckel-like syndromes. PMID:25902731

  18. The Periplasmic Nitrate Reductase NapABC Supports Luminal Growth of Salmonella enterica Serovar Typhimurium during Colitis

    PubMed Central

    Lopez, Christopher A.; Rivera-Chávez, Fabian; Byndloss, Mariana X.

    2015-01-01

    The food-borne pathogen Salmonella enterica serovar Typhimurium benefits from acute inflammation in part by using host-derived nitrate to respire anaerobically and compete successfully with the commensal microbes during growth in the intestinal lumen. The S. Typhimurium genome contains three nitrate reductases, encoded by the narGHI, narZYV, and napABC genes. Work on homologous genes present in Escherichia coli suggests that nitrate reductase A, encoded by the narGHI genes, is the main enzyme promoting growth on nitrate as an electron acceptor in anaerobic environments. Using a mouse colitis model, we found, surprisingly, that S. Typhimurium strains with defects in either nitrate reductase A (narG mutant) or the regulator inducing its transcription in the presence of high concentrations of nitrate (narL mutant) exhibited growth comparable to that of wild-type S. Typhimurium. In contrast, a strain lacking a functional periplasmic nitrate reductase (napA mutant) exhibited a marked growth defect in the lumen of the colon. In E. coli, the napABC genes are transcribed maximally under anaerobic growth conditions in the presence of low nitrate concentrations. Inactivation of narP, encoding a response regulator that activates napABC transcription in response to low nitrate concentrations, significantly reduced the growth of S. Typhimurium in the gut lumen. Cecal nitrate measurements suggested that the murine cecum is a nitrate-limited environment. Collectively, our results suggest that S. Typhimurium uses the periplasmic nitrate reductase to support its growth on the low nitrate concentrations encountered in the gut, a strategy that may be shared with other enteric pathogens. PMID:26099579

  19. Histone chaperones ASF1 and NAP1 differentially modulate removal of active histone marks by LID-RPD3 complexes during NOTCH silencing.

    PubMed

    Moshkin, Yuri M; Kan, Tsung Wai; Goodfellow, Henry; Bezstarosti, Karel; Maeda, Robert K; Pilyugin, Maxim; Karch, Francois; Bray, Sarah J; Demmers, Jeroen A A; Verrijzer, C Peter

    2009-09-24

    Histone chaperones are involved in a variety of chromatin transactions. By a proteomics survey, we identified the interaction networks of histone chaperones ASF1, CAF1, HIRA, and NAP1. Here, we analyzed the cooperation of H3/H4 chaperone ASF1 and H2A/H2B chaperone NAP1 with two closely related silencing complexes: LAF and RLAF. NAP1 binds RPD3 and LID-associated factors (RLAF) comprising histone deacetylase RPD3, histone H3K4 demethylase LID/KDM5, SIN3A, PF1, EMSY, and MRG15. ASF1 binds LAF, a similar complex lacking RPD3. ASF1 and NAP1 link, respectively, LAF and RLAF to the DNA-binding Su(H)/Hairless complex, which targets the E(spl) NOTCH-regulated genes. ASF1 facilitates gene-selective removal of the H3K4me3 mark by LAF but has no effect on H3 deacetylation. NAP1 directs high nucleosome density near E(spl) control elements and mediates both H3 deacetylation and H3K4me3 demethylation by RLAF. We conclude that histone chaperones ASF1 and NAP1 differentially modulate local chromatin structure during gene-selective silencing. PMID:19782028

  20. The Academy of Science of Bologna and the kidney.

    PubMed

    Bonomini, V; Campieri, C; Zuccoli, M

    1999-01-01

    The Academy of Science of Bologna, founded in 1711, played an important role in the development of medicine. Receiving the heritage of Malpighi's and Morgagni's researches, the academy encouraged nephrological studies, which produced articles published in its journal, the Commentarii. Since the Commentarii were widely distributed all over Europe, the nephrological research practiced in Bologna reached all the main academies of science, in a fruitful circulation of knowledge. The paper presents the nephrological contributions to the Commentarii in the 18th century, thus introducing physicians, like Domenico Galeazzi and Luigi Galvani, who were both professors at the University of Bologna and at the Academy of Science. In their work three main topics can be identified: uroscopy, anatomy of the kidney and renal pathologies. PMID:10213815

  1. Ready-to-wear reading glasses. American Academy of Ophthalmology.

    PubMed

    1991-09-01

    The purpose of the Committee on Ophthalmic Procedures Assessment is to evaluate on a scientific basis new and existing ophthalmic tests, devices, and procedures for their safety, efficacy, clinical effectiveness and appropriate uses. Evaluations include examination of available literature, epidemiological analyses when appropriate, and compilation of opinions from recognized experts and other interested parties. After appropriate review by all contributors, including legal counsel, assessments are submitted to the Academy's Board of Directors for consideration as official Academy policy. PMID:1945327

  2. AACN CSI Academy, part 2: Nurses emerge as change leaders.

    PubMed

    Iacono, Laura; Altman, Marian

    2015-08-01

    In the first part of this three-part series, we explored how the American Association of Critical-Care Nurses (AACN) Clinical Scene Investigator (CSI) Academy aids clinical nurses in cultivating skills that measurably demonstrate how nonproductive time is a misnomer that interferes with achieving optimal patient outcomes. Join us for part 2, as we examine how the CSI Academy helped one hospital's neurosurgical ICU (NSCU) nurses achieve zero CAUTIs. PMID:26201044

  3. Cold press sintering of simulated lunar basalt

    NASA Technical Reports Server (NTRS)

    Altemir, D. A.

    1993-01-01

    In order to predict the conditions for which the lunar regolith may be adequately sintered, experiments were conducted in which samples of simulated lunar basalt (MLS-1) were pressed at high pressures and then heated in an electric furnace. This sintering process may be referred to as cold press sintering since the material is pressed at room temperature. Although test articles were produced which possessed compressive strengths comparable to that of terrestrial concrete, the cold press sintering process requires very high press pressures and sintering temperatures in order to achieve that strength. Additionally, the prospect of poor internal heat transfer adversely affecting the quality of sintered lunar material is a major concern. Therefore, it is concluded that cold press sintering will most likely be undesirable for the production of lunar construction materials.

  4. Slurry-pressing consolidation of silicon nitride

    NASA Technical Reports Server (NTRS)

    Sanders, William A.; Kiser, James D.; Freedman, Marc R.

    1989-01-01

    A baseline slurry-pressing method for a silicon nitride material is developed. The Si3N4 composition contained 5.8 wt percent SiO2 and 6.4 wt percent Y2O3. Slurry-pressing variables included volume percent solids, application of ultrasonic energy, and pH. Twenty vol percent slurry-pressed material was approximately 11 percent stronger than both 30 vol percent slurry-pressed and dry-pressed materials. The Student's t-test showed the difference to be significant at the 99 percent confidence level. Twenty volume percent (300 h) slurry-pressed test bars exhibited strengths as high as 980 MPa. Large, columnar beta-Si3N4 grains caused failure in the highest strength specimens. The improved strength correlated with better structural uniformity as determined by radiography, optical microscopy, and image analysis.

  5. Slurry-pressing consolidation of silicon nitride

    NASA Technical Reports Server (NTRS)

    Sanders, William A.; Kiser, James D.; Freedman, Marc R.

    1988-01-01

    A baseline slurry-pressing method for a silicon nitride material is developed. The Si3N4 composition contained 5.8 wt percent SiO2 and 6.4 wt percent Y2O3. Slurry-pressing variables included volume percent solids, application of ultrasonic energy, and pH. Twenty vol percent slurry-pressed material was approximately 11 percent stronger than both 30 vol percent slurry-pressed and dry-pressed materials. The Student's t-test showed the difference to be significant at the 99 percent confidence level. Twenty volume percent (300 h) slurry-pressed test bars exhibited strengths as high as 980 MPa. Large, columnar beta-Si3N4 grains caused failure in the highest strength specimens. The improved strength correlated with better structural uniformity as determined by radiography, optical microscopy, and image analysis.

  6. Effects of unconditioned stimulus intensity and fear extinction on subsequent sleep architecture in an afternoon nap.

    PubMed

    Sturm, Anna; Czisch, Michael; Spoormaker, Victor I

    2013-12-01

    Impaired fear extinction and disturbed sleep coincide in post-traumatic stress disorder (PTSD), but the nature of this relationship is unclear. Rapid eye movement (REM) sleep deprivation impairs fear extinction recall in rodents and young healthy subjects, and animal models have demonstrated both disrupted sleep after fear conditioning and normalized sleep after extinction learning. As a correlation between unconditioned stimulus (US) responding and subsequent sleep architecture has been observed in healthy subjects, the goal of this study was to test whether US intensity would causally affect subsequent sleep. Twenty-four young healthy subjects underwent a fear conditioning session with skin conductance response measurements before an afternoon session of polysomnographically recorded sleep (up to 120 min) in the sleep laboratory. Two factors were manipulated experimentally in a 2 × 2 design: US (electrical shock) was set at high or low intensity, and subjects did or did not receive an extinction session after fear conditioning. We observed that neither factor affected REM sleep amount, that high US intensity nominally increased sleep fragmentation (more Stage 1 sleep, stage shifts and wake after sleep onset), and that extinction increased Stage 4 amount. Moreover, reduced Stage 1 and increased Stage 4 and REM sleep were associated with subjective sleep quality of the afternoon nap. These results provide evidence for the notion that US intensity and extinction affect subsequent sleep architecture in young healthy subjects, which may provide a translational bridge from findings in animal studies to correlations observed in PTSD patients. PMID:23919462

  7. Visual field information in nap-of-the-earth flight by teleoperated helmet-mounted displays

    NASA Astrophysics Data System (ADS)

    Grunwald, Arthur J.; Kohn, S.; Merhav, S. J.

    1991-08-01

    The human ability to derive control-oriented visual field information from tele-operated helmet-mounted displays (HMDs) in nap-of-the-earth flight is investigated. The visual field with these types of displays originates from a forward looking infrared radiation camera, gimbal-mounted at the front of the aircraft and slaved to the pilot''s line-of-sight to obtain wide-angle visual coverage. Although these displays are proven effective in Apache and Cobra helicopter night operations, they demand very high pilot proficiency and work load. Experimental work presented in the paper has shown that part of the difficulties encountered in vehicular control by means of these displays can be attributed to the narrow viewing aperture and head/camera slaving system phase lags. Both these shortcomings will impair visuo- vestibular coordination, when voluntary head rotation is present. This might result in errors in estimating the control-oriented visual field information vital in vehicular control, such as the vehicle yaw rate or the anticipated flight path, or might even lead to visuo-vestibular conflicts (motion sickness). Since, under these conditions, the pilot will tend to minimize head rotation, the full wide-angle coverage of the HMD, provided by the line-of-sight slaving system, is not always fully utilized.

  8. A NAP-Family Histone Chaperone Functions in Abiotic Stress Response and Adaptation.

    PubMed

    Tripathi, Amit K; Pareek, Ashwani; Singla-Pareek, Sneh Lata

    2016-08-01

    Modulation of gene expression is one of the most significant molecular mechanisms of abiotic stress response in plants. Via altering DNA accessibility, histone chaperones affect the transcriptional competence of genomic loci. However, in contrast to other factors affecting chromatin dynamics, the role of plant histone chaperones in abiotic stress response and adaptation remains elusive. Here, we studied the physiological function of a stress-responsive putative rice (Oryza sativa) histone chaperone of the NAP superfamily: OsNAPL6. We show that OsNAPL6 is a nuclear-localized H3/H4 histone chaperone capable of assembling a nucleosome-like structure. Utilizing overexpression and knockdown approaches, we found a positive correlation between OsNAPL6 expression levels and adaptation to multiple abiotic stresses. Results of comparative transcriptome profiling and promoter-recruitment studies indicate that OsNAPL6 functions during stress response via modulation of expression of various genes involved in diverse functions. For instance, we show that OsNAPL6 is recruited to OsRad51 promoter, activating its expression and leading to more efficient DNA repair and abrogation of programmed cell death under salinity and genotoxic stress conditions. These results suggest that the histone chaperone OsNAPL6 may serve a regulatory role in abiotic stress physiology possibly via modulating nucleosome dynamics at various stress-associated genomic loci. Taken together, our findings establish a hitherto unknown link between histone chaperones and abiotic stress response in plants. PMID:27342307

  9. Directional handling qualities requirements for nap-of-the-earth tasks

    NASA Technical Reports Server (NTRS)

    Bivens, C. C.

    1986-01-01

    A piloted similator experiment designed to investigate directional axis handling qualities requirements for low-speed and hover tasks conducted by a scout/attack helicopter is described. Included were the directional characteristics of various candidate light helicopter family (LHX) configurations. The test also focused on conventional single main/tail rotor configurations where the first-order effects that contribute to the loss of tail rotor control experienced by the OH-58 series aircraft were modeled. Two types of yaw stability and control augmentation systems were implemented: washed-out yaw rate feedback and shaped control input, and a yaw rate command, heading-hold system. The results of the experiment indicate that rotorcraft configurations with high directional gust sensitivity require more yaw damping to maintain satisfactory handling qualities during nap-of-the-earth (NOE) flying tasks. It was also determined that both yaw damping and control response are critical handling qualities parameters in performing the air-to-air target acquisition and tracking task. The lack of substantial yaw damping and larger values of gust sensitivity increased the possibility of loss of directional control at low airspeeds for the tail rotor configurations.

  10. A NAP-Family Histone Chaperone Functions in Abiotic Stress Response and Adaptation1[OPEN

    PubMed Central

    Pareek, Ashwani; Singla-Pareek, Sneh Lata

    2016-01-01

    Modulation of gene expression is one of the most significant molecular mechanisms of abiotic stress response in plants. Via altering DNA accessibility, histone chaperones affect the transcriptional competence of genomic loci. However, in contrast to other factors affecting chromatin dynamics, the role of plant histone chaperones in abiotic stress response and adaptation remains elusive. Here, we studied the physiological function of a stress-responsive putative rice (Oryza sativa) histone chaperone of the NAP superfamily: OsNAPL6. We show that OsNAPL6 is a nuclear-localized H3/H4 histone chaperone capable of assembling a nucleosome-like structure. Utilizing overexpression and knockdown approaches, we found a positive correlation between OsNAPL6 expression levels and adaptation to multiple abiotic stresses. Results of comparative transcriptome profiling and promoter-recruitment studies indicate that OsNAPL6 functions during stress response via modulation of expression of various genes involved in diverse functions. For instance, we show that OsNAPL6 is recruited to OsRad51 promoter, activating its expression and leading to more efficient DNA repair and abrogation of programmed cell death under salinity and genotoxic stress conditions. These results suggest that the histone chaperone OsNAPL6 may serve a regulatory role in abiotic stress physiology possibly via modulating nucleosome dynamics at various stress-associated genomic loci. Taken together, our findings establish a hitherto unknown link between histone chaperones and abiotic stress response in plants. PMID:27342307

  11. Visual field information in Nap-of-the-Earth flight by teleoperated Helmet-Mounted displays

    NASA Technical Reports Server (NTRS)

    Grunwald, Arthur J.; Kohn, S.; Merhav, S. J.

    1991-01-01

    The human ability to derive Control-Oriented Visual Field Information from teleoperated Helmet-Mounted displays in Nap-of-the-Earth flight, is investigated. The visual field with these types of displays originates from a Forward Looking Infrared Radiation Camera, gimbal-mounted at the front of the aircraft and slaved to the pilot's line-of-sight, to obtain wide-angle visual coverage. Although these displays are proved to be effective in Apache and Cobra helicopter night operations, they demand very high pilot proficiency and work load. Experimental work presented in the paper has shown that part of the difficulties encountered in vehicular control by means of these displays can be attributed to the narrow viewing aperture and head/camera slaving system phase lags. Both these shortcomings will impair visuo-vestibular coordination, when voluntary head rotation is present. This might result in errors in estimating the Control-Oriented Visual Field Information vital in vehicular control, such as the vehicle yaw rate or the anticipated flight path, or might even lead to visuo-vestibular conflicts (motion sickness). Since, under these conditions, the pilot will tend to minimize head rotation, the full wide-angle coverage of the Helmet-Mounted Display, provided by the line-of-sight slaving system, is not always fully utilized.

  12. NASA/MSFC Large Stretch Press Study

    NASA Technical Reports Server (NTRS)

    Choate, M. W.; Nealson, W. P.; Jay, G. C.; Buss, W. D.

    1985-01-01

    The purpose of this study was to: A. assess and document the advantages/disadvantages of a government agency investment in a large stretch form press on the order of 5000 tons capacity (per jaw); B. develop a procurement specification for the press; and C. provide trade study data that will permit an optimum site location. Tasks were separated into four major elements: cost study, user survey, site selection, and press design/procurement specification.

  13. Identification of two domains and distal histidine ligands to the four haems in the bacterial c-type cytochrome NapC; the prototype connector between quinol/quinone and periplasmic oxido-reductases.

    PubMed

    Cartron, Michaël L; Roldán, M Dolores; Ferguson, Stuart J; Berks, Ben C; Richardson, David J

    2002-12-01

    NapC is a tetra-haem member of a family of bacterial membrane-anchored multi-haem c -type cytochromes implicated in electron transfer between membrane quinols and periplasmic enzymes. The water-soluble tetra-haem fragment of Paracoccus pantotrophus NapC has been expressed as a periplasmic protein (NapC(sol)) in Paracoccus denitrificans, P. pantotrophus and Escherichia coli. Site-specific mutagenesis of NapC(sol), combined with spectroscopic studies, suggests that each haem iron centre has bis -histidinyl co-ordination. Four proximal ligands arise from each of four Cys-Xaa-Xaa-Cys-His haem-binding motifs; candidates for the four distal ligands are His(81), His(99), His(174) and His(194). NapC(H81A), NapC(H99A), NapC(H174A) and NapC(H194A) mutants (with alanine substituted for each of the four candidate residues) have all been purified from E. coli. In each case, one of the haems has become high-spin, as judged by the presence of a broad absorption band between 620 nm and 650 nm for the oxidized cytochrome; this feature is absent for wild-type protein and presumably arises because of the absence of the distal histidine ligand from one of the haems. NapC(H81A) and NapC(H174A) are less well expressed in E. coli than NapC(H99A) and NapC(H194A) and cannot be detected when expressed in P. denitrificans or P. pantotrophus. In vitro and in vivo complementation studies demonstrate that the soluble periplasmic NapC can mediate electron transfer from quinols to the periplasmic nitrate reductase. This capacity was retained in vitro with the NapC(H99A) and NapC(H194A) mutants but was lost in vivo. A model for the structural organization of NapC(sol) into two domains, each containing a di-haem pair, is proposed. In this model, each haem pair obtains one distal haem ligand from its own domain and a second from the other domain. The suggestion of two domains is supported by observations that the 24 kDa NapC(sol) cleaves to yield a 12 kDa haem-staining band. Determination of the

  14. Identification of two domains and distal histidine ligands to the four haems in the bacterial c-type cytochrome NapC; the prototype connector between quinol/quinone and periplasmic oxido-reductases.

    PubMed Central

    Cartron, Michaël L; Roldán, M Dolores; Ferguson, Stuart J; Berks, Ben C; Richardson, David J

    2002-01-01

    NapC is a tetra-haem member of a family of bacterial membrane-anchored multi-haem c -type cytochromes implicated in electron transfer between membrane quinols and periplasmic enzymes. The water-soluble tetra-haem fragment of Paracoccus pantotrophus NapC has been expressed as a periplasmic protein (NapC(sol)) in Paracoccus denitrificans, P. pantotrophus and Escherichia coli. Site-specific mutagenesis of NapC(sol), combined with spectroscopic studies, suggests that each haem iron centre has bis -histidinyl co-ordination. Four proximal ligands arise from each of four Cys-Xaa-Xaa-Cys-His haem-binding motifs; candidates for the four distal ligands are His(81), His(99), His(174) and His(194). NapC(H81A), NapC(H99A), NapC(H174A) and NapC(H194A) mutants (with alanine substituted for each of the four candidate residues) have all been purified from E. coli. In each case, one of the haems has become high-spin, as judged by the presence of a broad absorption band between 620 nm and 650 nm for the oxidized cytochrome; this feature is absent for wild-type protein and presumably arises because of the absence of the distal histidine ligand from one of the haems. NapC(H81A) and NapC(H174A) are less well expressed in E. coli than NapC(H99A) and NapC(H194A) and cannot be detected when expressed in P. denitrificans or P. pantotrophus. In vitro and in vivo complementation studies demonstrate that the soluble periplasmic NapC can mediate electron transfer from quinols to the periplasmic nitrate reductase. This capacity was retained in vitro with the NapC(H99A) and NapC(H194A) mutants but was lost in vivo. A model for the structural organization of NapC(sol) into two domains, each containing a di-haem pair, is proposed. In this model, each haem pair obtains one distal haem ligand from its own domain and a second from the other domain. The suggestion of two domains is supported by observations that the 24 kDa NapC(sol) cleaves to yield a 12 kDa haem-staining band. Determination of the

  15. Chain Effects: The Impact of Academy Chains on Low Income Students

    ERIC Educational Resources Information Center

    Hutchings, Merryn; Francis, Becky; De Vries, Robert

    2014-01-01

    The authors analysed school performance data to review how well disadvantaged pupils achieve in academy chains. They included chains only if they had at least three academies in 2013, and two sponsored secondary academies for the whole period from September 2010 to July 2013. This means that academies are included in our analysis only when there…

  16. 26 CFR 1.1397E-1 - Qualified zone academy bonds.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... apply to bonds issued under section 1397E pursuant to allocations of the national qualified zone academy... 26 Internal Revenue 11 2012-04-01 2012-04-01 false Qualified zone academy bonds. 1.1397E-1 Section... academy bonds. (a) In general—(1) Overview. In general, a qualified zone academy bond (QZAB or QZABs) is...

  17. The Impact of Career Academy Programs on Student Achievement in a New Jersey Urban High School

    ERIC Educational Resources Information Center

    Ahmad, Abdul-Azeem

    2009-01-01

    The Talent Development High School (TDHS) reform model, with career academy programs, was introduced at Randolph High School. Three academies were implemented, one called the Arts and Humanities Academy (A&H) focused on careers in creative arts, law, and public service; another titled the Business and Industrial Technology Academy (BAIT) was…

  18. 77 FR 57102 - Board of Visitors for the National Fire Academy

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-17

    ... SECURITY Federal Emergency Management Agency Board of Visitors for the National Fire Academy AGENCY... Committee Meeting. SUMMARY: The Board of Visitors for the National Fire Academy (Board) will meet on October... programs of the National Fire Academy (Academy) and advise the Administrator of the Federal...

  19. 77 FR 41196 - Board of Visitors for the National Fire Academy

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-12

    ... SECURITY Federal Emergency Management Agency Board of Visitors for the National Fire Academy AGENCY... Committee Teleconference Meeting. SUMMARY: The Board of Visitors for the National Fire Academy (Board) will... programs of the National Fire Academy (Academy) and advise the Administrator of the Federal...

  20. 77 FR 21576 - Board of Visitors for the National Fire Academy

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-10

    ... SECURITY Federal Emergency Management Agency Board of Visitors for the National Fire Academy AGENCY... Committee Teleconference Meeting. SUMMARY: The Board of Visitors for the National Fire Academy (Board) will... The purpose of the Board is to review annually the programs of the National Fire Academy (Academy)...

  1. Career Academies: Educating Urban Students for Career Success. ERIC/CUE Digest, Number 84.

    ERIC Educational Resources Information Center

    Burnett, Gary

    This ERIC Digest reviews the school restructuring tool of career academies serving the non-college bound student. The career academy movement began with the Electrical Academy in Philadelphia, Pennsylvania. The model was exported to California where it became the basis for the Peninsula Academies in the Sequoia Union High School District and from…

  2. The Prussian Academy of Sciences and Humanities during the Weimar Republic

    ERIC Educational Resources Information Center

    Hardtwig, Wolfgang

    2004-01-01

    The German Revolution of November 1918 dramatically altered the Academy's view of its relationship with government. In particular, the Academy's Prussian tradition had to be rethought. From initial wariness to grudging acceptance, the Academy came to accept the Weimar regime. This paper studies the politics of the Academy, uncovers factions and…

  3. [The press and family planning].

    PubMed

    Abraham De D'ornellas, R

    1987-01-01

    The treatment in the press of family planning hinges on two fundamental factors: the taboo of the leftist groups and the taboo of the Catholic Church, whose head is against abortion under any circumstances. Leftist views insinuate that family planning is the genocidal plan of North American imperialists against the Third World and, in particular, against Latin America. This genocidal plan is supposed to subject poor populations to international schemes. In the press family planning is often treated in a sanctimonious fashion, lumping it together with topics like pornography, sex, and violence. In 1983 the daily newspaper Expreso published a supplement running every week for almost three months about the issue of population, which dealt fairly extensively with such topics as population and housing, education, employment, and urban proliferation, as well as responsible parenthood and child survival. In addition, there was a detailed description of contraceptive methods. In October 1986 another surprising thing happened: the President of Peru talked about the topic of family planning, which at the time was an act of courage. Since then much has changed; the whole world is interested in family planning and certain aspects of population. Since October 1986 more has been published in this domain than during the preceding 20 years. In contrast, the Church reacted differently to this issue: after some initial caution, the conference of Peruvian bishops attacked all methods of modern contraceptives and private institutions of family planning. The information boom in family planning will certainly continue. At the moment this flood of articles and editorials about the issue is an expression of the anxiety of families related to uncontrolled reproduction and the fear of overpopulation in large cities devoid of minimal services. PMID:12281466

  4. Systemic Mentoring for Competitiveness: The Model of the Timbuktu Academy

    NASA Astrophysics Data System (ADS)

    Bagayoko, Diola

    2010-02-01

    The Timbuktu Academy is a comprehensive, systemic mentoring program at Southern University and A&M College in Baton Rouge (SUBR), Louisiana. We define systemic mentoring as one that is woven into the core functions of an organization. For most universities, those functions include instruction, research, and service. While the Academy has programs for pre-college and graduate students, its Ten-Strand Systemic Mentoring Model was specifically tailored to undergraduate education. We discuss basic considerations that led to the paradigm, programs, activities, and results of the Timbuktu Academy. The proper implementation of the Ten-Strand Systemic Mentoring Model couples teaching and superior learning, on the one hand, and integrates research and education, on the other hand. For undergraduate education, key strands include support (financially or otherwise), scientific advisement, research participation (academic year or summer), immersion in a professional culture, monitoring, and guidance to graduate school. From the summer of 1994 to 2009, the Academy has engaged 2,093 pre-college scholars in its summer programs. To date, the Academy has assisted in the production of one hundred seventy (170) minority undergraduate scholars who have earned a Bachelor of Science degree. Seventy (70) of 83 physics graduates, twenty (20) of 29 chemistry graduates, and twenty-two (22) of 49 engineering graduates have earned graduate degrees or are successfully enrolled in graduate school, with emphasis on the pursuit of the Ph.D. For the above model and results, the Timbuktu Academy received the 2002 U.S. Presidential Award for Excellence in Science, Mathematics, and Engineering Mentoring. Its director was among the first individual recipients of this award in 1996. The handouts accompanying this presentation are intended to facilitate the adaptive replication of the Timbuktu Academy by individuals, departments, colleges and universities, and other organizations. )

  5. The Press vs. Professional Wrestling: How the Press Covered WrestleMania III.

    ERIC Educational Resources Information Center

    Ortizano, Giacomo L.

    This paper analyzes the relationship between the press and professional wrestling. It examines professional wrestling as a business and the conflicting goals of the promoters and the press. The paper focuses on how the press covered the most widely viewed professional wrestling show of all time, WrestleMania III (looking at newspaper coverage…

  6. New Worlds, New Horizons in Astronomy and Astrophysics, Washington, D.C.: National Academies Press, 2010. Panel Reports New Worlds, New Horizons in Astronomy and Astrophysics, Washington, D.C.: National Academies Press, 2010. Report of the Panel on Implementing Recommendations from the New Worlds, New Horizons Decadal Survey, Washington, D.C.: National Academies Press, 2010. 2020 Vision: An Overview of New Worlds, New Horizons in Astronomy and Astrophysics, Washington, D.C.: National Academies Press, 2011

    SciTech Connect

    Shapero, Donald C.

    2012-04-05

    The NRC's Astronomy and Astrophysics decadal survey Astro2010 was organized under the umbrella of the BPA and its sister board the Space Studies Board (SSB). NASA, NSF, and DOE are the sponsors of this survey that was asked to evaluate the field of space- and ground-based astronomy and astrophysics, recommending priorities for the most important scientific and technical activities of the decade 2010-2020. The principal goals of this study were to carry out an assessment of activities in astronomy and astrophysics, including both new and previously identified concept, and to prepare a concise report that addresses the agencies supporting the field, the Congressional committees with jurisdiction over those agencies, the scientific community, and the public. Over the past 40 years, the Astronomy and Astrophysics decadal reviews have played a vital role in the selection of major astronomical activities and subsequent scientific discoveries. Some decadal survey prioritization highlights include the development of adaptive optics systems, the Very Long Baseline Array, the Hubble Space Telescope, and the Spitzer Space Telescope.

  7. Research at the Intersection of the Physical and Life Sciences, Washington, D.C.: National Academies Press, 2010.

    SciTech Connect

    Committee on Forefronts of Science at the Interface of Physical and Life Sciences

    2009-11-01

    Traditionally, the natural sciences have been divided into two branches: the biological sciences and the physical sciences. Today, an increasing number of scientists are addressing problems lying at the intersection of the two. These problems are most often biological in nature, but examining them through the lens of the physical sciences can yield exciting results and opportunities. For example, one area producing effective cross-discipline research opportunities centers on the dynamics of systems. Equilibrium, multi-stability, and stochastic behavior--concepts familiar to physicists and chemists--are now being used to tackle issues associated with living systems such as adaptation, feedback, and emergent behavior. Research at the Intersection of the Physical and Life Sciences discusses how some of the most important scientific and societal challenges can be addressed, at least in part, by collaborative research that lies at the intersection of traditional disciplines, including biology, chemistry, and physics. This book describes how some of the mysteries of the biological world are being addressed using tools and techniques developed in the physical sciences, and identifies five areas of potentially transformative research. Work in these areas would have significant impact in both research and society at large by expanding our understanding of the physical world and by revealing new opportunities for advancing public health, technology, and stewardship of the environment. This report recommends several ways to accelerate such cross-discipline research. Many of these recommendations are directed toward those administering the faculties and resources of our great research institutions--and the stewards of our research funders, making this book an excellent resource for academic and research institutions, scientists, universities, and federal and private funding agencies.

  8. Teenagers as Victims in the Press

    ERIC Educational Resources Information Center

    Andersson, Gunvor; Lundstrom, Tommy

    2007-01-01

    Research into press reporting on young people has tended to concentrate on young people as offenders. In contrast, this article focuses on press coverage of teenagers as victims. Reports in two Swedish newspapers (a morning broadsheet and an evening tabloid) were studied over a period of four months and subjected to a qualitative analysis of…

  9. Special Section: University Presses and Libraries.

    ERIC Educational Resources Information Center

    Berry, John; And Others

    1986-01-01

    Describes issues discussed at the Association of American University Presses, June 1986 meeting, as being divided between those interested in using the techniques of commercial publishers and those committed to publishing what is worthy. Chandler Grannis describes "New Directions for University Presses" and Doug Armato "The Power of 'Serious'…

  10. The Lily-White University Presses.

    ERIC Educational Resources Information Center

    Shin, Annys

    1996-01-01

    Argues that the university presses are immune from racial change and discusses the problem of using location as an argument for not being able to lure blacks into university publishing. Howard University Press is used to illustrate the problem of budget cutting and the ability to boost black recruitment efforts or establish a united black press…

  11. The Mythology of the Penny Press.

    ERIC Educational Resources Information Center

    Nerone, John C.

    1987-01-01

    Examines common scholarly characterizations of the American penny press of the 1830s and 40s that together provide a myth of origins of the contemporary U.S. press. Criticizes inaccuracies and misleading elements in this mythology and its implications for subsequent debate about U.S. journalism. (JK)

  12. The Egyptian Press: An Official Fourth Estate.

    ERIC Educational Resources Information Center

    Lawhorne, Clifton O.

    A descriptive study based on Egyptian law, printed sources, and interviews clarifies our picture of the Egyptian Press by examining its status as a constitutionally mandated "Fourth Estate." The constitutional amendment, the resultant Egyptian Press Law, and the "Law Of Shame" (all passed in 1980), are designed to create a heavily controlled press…

  13. Freedom of the Press vs. Public Access.

    ERIC Educational Resources Information Center

    Schmidt, Benno C., Jr.

    This book surveys the implications of freedom of the press for a constitutionally rooted public right of access to electronic and print media. Part one provides general perspectives on access to the media, including discussions of access in relation to the Supreme Court, to First Amendment history and theory, to current perceptions of the press,…

  14. Fracture toughness of hot-pressed beryllium

    NASA Technical Reports Server (NTRS)

    Lemon, D. D.; Brown, W. F., Jr.

    1985-01-01

    This paper presents the results of an investigation into the fracture toughness, sustained-load flaw growth, and fatigue-crack propagation resistance of S200E hot-pressed beryllium at room temperature. It also reviews the literature pertaining to the influence of various factors on the fracture toughness of hot-pressed beryllium determined using fatigue-cracked specimens.

  15. The Pedagogical Press: Problems and Trends.

    ERIC Educational Resources Information Center

    Soviet Education, 1990

    1990-01-01

    Presents a discussion by journalists, scientists, and writers on educational problems in the Soviet Union. Focuses on the the role of the pedagogical press in restructuring public education in light of perestroika. Calls for press involvement in defining and developing public education. Lists questions for consideration and invites responses. (NL)

  16. Characteristics of nitrogen release from synthetic zeolite Na-P1 occluding NH4NO3.

    PubMed

    Park, Man; Kim, Jong Su; Choi, Choong Lyeal; Kim, Jang-Eok; Heo, Nam Ho; Komarneni, Sridhar; Choi, Jyung

    2005-08-18

    Zeolites can accommodate a considerable amount of occluded salt such as NH4NO3, which can serve as a good source of slow-release plant nutrient. This study evaluates the kinetics of ion release from NH4NO3-occluded Na-P1 (N-NaP) using a simulated soil solution and deionized water as leaching solutions. The patterns of ion releases were examined as a function of leaching time under both static and continuous-flow conditions for more than one month. Releases of both NH4+ and NO3- from N-NaP were found to be slow and steady under both the above conditions. The soil solution affected the release of NH4+ and NO3- differently, while deionized water released nearly the same equivalents of these ions. This clearly indicates that ion release from salt-occluded zeolite involves two different reactions, cation exchange and dissolution. The kinetics of ion release from occluded NH4NO3 under static condition was best described by the standard Elovich model while the power function model best expressed these under continuous-flow condition. The initial ion release patterns under both conditions exhibited considerable deviation from the simulated models, probably as a result of the presence of hydrated occluded NH4NO3. Flow condition and the presence of electrolytes in leaching solution affected the release kinetics significantly. Release of occluded NH4NO3 was delayed by the presence of the NH4NO3 coated on zeolite crystals. These results indicate that the ion release property of occluded salt could be predicted and controlled. This study clearly shows that NH4NO3-occluded zeolites could be developed as slow release fertilizers. PMID:15963593

  17. The Management Academy for Public Health: the South Carolina experience.

    PubMed

    Cumbey, Dorothy A; Ellison, Lu Anne

    2006-01-01

    In the late 1990s, the South Carolina Department of Health and Environmental Control (SCDHEC) was faced with the challenges of a workforce that was not prepared in public health; the impending loss of significant agency expertise, leadership, and institutional knowledge through retirement; the lack of available and accessible training; and continuing state budget cuts. Preparedness for bioterrorism and other public health emergencies was also of concern, a need made more urgent after 2001. To respond to current and emerging public health challenges, the SCDHEC had to have a workforce with the knowledge and skills necessary for the delivery of essential public health services. To address these challenges, the department partnered with the University of North Carolina in the pilot of the Management Academy for Public Health. The Management Academy is now integrated into the South Carolina workforce development strategy, and 199 staff members and 22 community partners have graduated from the program. Along with increased knowledge, skills, and abilities of individual staff and increased organizational and community capacity, a significant result of South Carolina's experience with the Management Academy for Public Health is the development of a training program for emergency preparedness modeled on the Management Academy. This highly successful program illustrates the replicability of the Management Academy model. PMID:16912610

  18. Designing and implementing the Army Nursing Leader Academy.

    PubMed

    Dunemn, Kathleen; Hopkins-Chadwick, Denise L; Connally, Tina; Bramley, Kelly

    2011-01-01

    In 2008, the Chief of the Army Nurse Corps directed a thorough review of existing training programs available to and provided for Army Nursing personnel for the development of full-spectrum leaders for Army Nursing. The review provided the gap analysis necessary to restructure courses provided by the Department of Nursing Science at the Army Medical Department Center and School. This new grouping of courses is referred to as the Army Nursing Leader Academy. The Army Nursing Leader Academy is the first of its kind in that it addresses career-long learning of all Army Nursing by focusing on building skills, knowledge, and behaviors to produce sustainable, full-spectrum leaders. The Nursing Leader Academy consists of a series of sequential nurse leader development courses combined with a web based resource center. Grounded in the Patient CaringTouch System, guided by nurse competencies, and gauged by the Leader Capabilities Map, the Nursing Leader Academy provides learning that is relevant and timely designed to reinforce enterprise values and culture to ensure readiness for successive roles and positions. Full implementation of the Nursing Leader Academy will include the evidence-based elements of formal schooling, coaching, self-development, functional/technical (competency attainment), and professional experiences. PMID:22124867

  19. An American Academy for Training Safeguards Inspectors - An Idea Revisited

    SciTech Connect

    Philip Casey Durst; Robert Bean

    2010-07-01

    In 2009, we presented the idea of an American academy for training safeguards inspectors for the International Atomic Energy Agency (IAEA), due to the declining percentage of Americans in that international organization. In this paper we assert that there is still a compelling need for this academy. While the American Safeguards Academy would be useful in preparing and pre-training American inspectors for the IAEA, it would also be useful for preparing Americans for domestic safeguards duties in the U.S. Department of Energy (DOE), U.S. DOE National Laboratories, and the U.S. Nuclear Regulatory Commission (NRC). It is envisioned that such an academy would train graduate and post-graduate university students, DOE National Laboratory interns, and nuclear safeguards professionals in the modern equipment, safeguards measures, and approaches currently used by the IAEA. It is also envisioned that the Academy would involve the domestic nuclear industry, which could provide use of commercial nuclear facilities for tours and demonstrations of the safeguards tools and methods in actual nuclear facilities. This would be in support of the U.S. DOE National Nuclear Security Administration’s Next Generation Safeguards Initiative (NGSI). This training would also help American nuclear safeguards and non-proliferation professionals better understand the potential limitations of the current tools used by the IAEA and give them a foundation from which to consider even more effective and efficient safeguards measures and approaches.

  20. ACTIVITY-DEPENDENT NEUROPROTECTIVE PROTEIN–DERIVED PEPTIDE, NAP, PREVENTING ALCOHOL-INDUCED APOPTOSIS IN FETAL BRAIN OF C57BL/6 MOUSE

    PubMed Central

    SARI, Y.

    2012-01-01

    Possible prevention of the effects of prenatal alcohol exposure has been investigated using peptides that were previously shown to be involved in neuroprotection both in vitro and in vivo. I focused in this study on investigating the neuro-protective effects of one of these peptides with regard to the determination of the downstream signaling pathways involved in neuroprotection. This peptide with the sequence NAPVSIPQ, known as NAP, a fragment of activity-dependent neuroprotective protein, demonstrated a potent protective effect against oxidative stress associated with alcohol exposure. On embryonic day 7 (E7), weight-matched C57BL/6 pregnant females were assigned the following groups: (1) Ethanol liquid diet group (ALC) 25% (4.49%, v/v) ethano-derived calories, (2) Pair-fed (PF) control group (3) Chow control group, (4) treatment groups with alcohol alongside i.p. injections of d-NAP (ALC/d-NAP, 20 or 30 μg/20 g body weight), (5) PF/d-NAP control group. On E13, fetal brains were collected and assayed for TdT-mediated dUTP nick end labeling (TUNEL) staining, caspase-3 colorimetric assay and ELISA for cytochrome c detection. My results show that NAP significantly prevented alcohol-induced weight reduction of the fetal brain. Apoptosis was determined by TUNEL staining; NAP administration significantly prevented alcohol-induced increases in TUNEL-positive cells in primordium cingulate cortex and basal ganglia eminence. The investigation of downstream signaling pathways involving NAP neuroprotection revealed that this peptide significantly prevented alcohol-induced increase in the concentrations of caspase-3 in E13 fetal brains. Moreover, ELISA for cytochrome c shows that NAP significantly prevented both alcohol-induced increases in the level of cytosolic cytochrome c and alcohol-induced decreases in the level of mitochondrial cytochrome c. These data provide an understanding of NAP intracellular target, and the downstream mechanisms of action that will pave a path

  1. The Reluctant Reformation: On Criticizing the Press in America.

    ERIC Educational Resources Information Center

    Brown , Lee

    This book examines the status of the press and the criticism surrounding it. Chapter 1 attempts to relate theories of criticism to the contemporary press, to define the public interest relative to the press, and to discuss the role of criticism and the social responsibility of the press. Chapter 2 presents a brief history of press criticism from…

  2. Hierarchy of Carbon Source Selection in Paracoccus pantotrophus: Strict Correlation between Reduction State of the Carbon Substrate and Aerobic Expression of the nap Operon

    PubMed Central

    Ellington, M. J. K.; Bhakoo, K. K.; Sawers, G.; Richardson, D. J.; Ferguson, S. J.

    2002-01-01

    Paracoccus pantotrophus can express a periplasmic nitrate reductase (Nap) during aerobic growth. A proposed role for this enzyme is the dissipation of excess redox energy during oxidative metabolism of reduced carbon substrates. To investigate the regulation of nap expression, a transcriptional fusion between the nap promoter region of P. pantotrophus and the lacZ gene was constructed. When this fusion was used, analyses showed that transcription from the nap promoter increases as the average reduction state of the carbon atoms increases. Thus, β-galactosidase activities increase as the carbon source changes in the order succinate-acetate-butyrate. This result was obtained regardless of which of the three carbon sources was used for culture of the inoculum. If two carbon sources were presented together, the β-galactosidase activity was always the same as it was when the least-reduced carbon source was added alone. This suggests that the regulation is dependent upon metabolism of the more-reduced carbon sources rather than just their presence in the medium. Analysis of culture medium by 1H nuclear magnetic resonance showed that for aerobic growth P. pantotrophus strictly selected its carbon source in the order succinate-acetate-butyrate. This was reflected by diauxic growth kinetics on medium containing mixed carbon substrates. The regulatory mechanism underpinning such a selection is unknown but is likely to be related to the mechanism which controls the transcription of the nap operon. PMID:12169601

  3. [Navy medical academy (to the 75th anniversary of establishment)].

    PubMed

    Chernikov, O G; Zaimagov, S V

    2016-02-01

    The article is devoted to the history of the creation in 1940 of the Naval Medical Academy on the basis of the 3rd Leningrad Medical Institute and the Institute for sanitary-chemical protection of the People's Commissariat of the USSR. The structure of this institution included, faculties management staff of the medical service, medical and sanitation, Higher Naval Medical School, the Marine Research Institute Medical, higher courses for officers of the medical service, clinical naval hospital. During the period of its activity (1940-1956), the staff of the Naval Medical Academy made a great contribution to the naval medicine and practical public health. The merit of the Academy is not only a beautifully staged academic, medical, research process, but also in the creation of the spirit of the high sea camaraderie, accomplishment and pride for the work which its graduates have dedicated their lives. PMID:27263215

  4. Health policy, ethics, and the Kansas Legislative Health Academy.

    PubMed

    Blacksher, Erika; Maree, Gina; Schrandt, Suzanne; Soderquist, Chris; Steffensmeier, Tim; St Peter, Robert

    2015-03-01

    We describe a unique program, the Kansas Legislative Health Academy, that brings together state legislators from across the political spectrum to build their capacity in advancing policies that can improve the health of Kansans. To that end, the academy helps legislators develop new skills to deliberate the ethics of health policy, use systems thinking to understand the long- and short-term effects of policy action and inaction, and engage in acts of civic leadership. The academy also seeks to foster an environment of respectful open dialogue and to build new cross-chamber and cross-party relationships. Among the most important outcomes cited by program participants is the value of sustained, personal interaction and problem solving with individuals holding differing political views. PMID:25607945

  5. 5th National Audit Project (NAP5) on accidental awareness during general anaesthesia: summary of main findings and risk factors.

    PubMed

    Pandit, J J; Andrade, J; Bogod, D G; Hitchman, J M; Jonker, W R; Lucas, N; Mackay, J H; Nimmo, A F; O'Connor, K; O'Sullivan, E P; Paul, R G; Palmer, J H M G; Plaat, F; Radcliffe, J J; Sury, M R J; Torevell, H E; Wang, M; Hainsworth, J; Cook, T M

    2014-10-01

    We present the main findings of the 5th National Audit Project (NAP5) on accidental awareness during general anaesthesia (AAGA). Incidences were estimated using reports of accidental awareness as the numerator, and a parallel national anaesthetic activity survey to provide denominator data. The incidence of certain/probable and possible accidental awareness cases was ~1:19,600 anaesthetics (95% confidence interval 1:16,700-23,450). However, there was considerable variation across subtypes of techniques or subspecialities. The incidence with neuromuscular block (NMB) was ~1:8200 (1:7030-9700), and without, it was ~1:135,900 (1:78,600-299,000). The cases of AAGA reported to NAP5 were overwhelmingly cases of unintended awareness during NMB. The incidence of accidental awareness during Caesarean section was ~1:670 (1:380-1300). Two-thirds (82, 66%) of cases of accidental awareness experiences arose in the dynamic phases of anaesthesia, namely induction of and emergence from anaesthesia. During induction of anaesthesia, contributory factors included: use of thiopental, rapid sequence induction, obesity, difficult airway management, NMB, and interruptions of anaesthetic delivery during movement from anaesthetic room to theatre. During emergence from anaesthesia, residual paralysis was perceived by patients as accidental awareness, and commonly related to a failure to ensure full return of motor capacity. One-third (43, 33%) of accidental awareness events arose during the maintenance phase of anaesthesia, mostly due to problems at induction or towards the end of anaesthesia. Factors increasing the risk of accidental awareness included: female sex, age (younger adults, but not children), obesity, anaesthetist seniority (junior trainees), previous awareness, out-of-hours operating, emergencies, type of surgery (obstetric, cardiac, thoracic), and use of NMB. The following factors were not risk factors for accidental awareness: ASA physical status, race, and use or omission

  6. Mechanical Properties from PBX 9501 Pressing Study

    NASA Astrophysics Data System (ADS)

    Graff Thompson, Darla; Wright, Walter J.

    2004-07-01

    A PBX 9501 pressing study was conducted by researchers in ESA-WMM, LANL, to identify the hydrostatic pressing parameters most important in fabricating high-density parts with uniform density. In this study, 31 charges were pressed using a full permutation of six pressing parameters. Five charges from the set of 31 were selected for an evaluation of their mechanical properties, specifically uniaxial compression and tension. Charges were selected to 1) span the density range of the study, and 2) allow two direct comparisons of pressing parameters independent of bulk density (density has a well-established affect on some material properties). Three PBX 9501 charges pressed isostatically at Pantex Plant in Amarillo, TX were also included in the study. The tensile properties of the 8 charges varied significantly. Careful evaluation of the results suggests that an increase in pressing temperature may correlate with an increase in tensile stress (strength) and a decrease in strain (ductility). Trends in compression exist but are less pronounced. In an effort to explore the relationship between pressing temperature and tensile strength, four sheets of Estane polymer (a component of the PBX 9501 binder) were compression molded at 70, 90, 110 and 130°C. The tensile strength of Estane was observed to increase by a factor of nearly 20 when the molding temperature was increased from 70 to 90°C (strength increase was negligible beyond 90°C). We present an outline of ongoing work that will irrefutably quantify the mechanical property affects of both pressing temperature and dwell time on PBX 9501.(LA-UR 03-4842).

  7. Rein and Zheng Elected to American Academy of Microbiology | Poster

    Cancer.gov

    By Nancy Parrish, Staff Writer Earlier this year, Alan Rein, Ph.D., and Zhi-Ming (Thomas) Zheng, M.D., Ph.D., were elected to fellowship in the American Academy of Microbiology, the honorific leadership group within the American Society for Microbiology (ASM). They were among 88 microbiologists who were elected to the academy “through a highly selective, peer-review process, based on their records of scientific achievement and original contributions that have advanced microbiology,” according to the society’s website.

  8. Rein and Zheng Elected to American Academy of Microbiology | Poster

    Cancer.gov

    By Nancy Parrish, Staff Writer Earlier this year, Alan Rein, Ph.D., and Zhi-Ming (Thomas) Zheng, M.D., Ph.D., were elected to fellowship in the American Academy of Microbiology, the honorific leadership group within the American Society for Microbiology (ASM). They were among 88 microbiologists who were elected to the academy “through a highly selective, peer-review process, based on their records of scientific achievement and original contributions that have advanced microbiology,” according to the society’s website.

  9. STS-8 onboard crew press conference

    NASA Technical Reports Server (NTRS)

    1983-01-01

    Six news reporters listen to a response from Astronaut Guion S. Bluford (note TV monitor) in a rare space-to-Earth press conference involving all the STS-8 crew. The participants are, left to right, Gary Schwitzer, Cable News Network; Morton Dean, CBS; Roy Neal, NBC; Lynn Sherr, ABC; Howard Benedict, Associated Press; Al Rossiter, United Press International. The astronauts on the monitor are Richard H. Truly, cneter left, crew commander; Daniel C. Brandenstein, lower left, pilot; and Dr. William E. Thornton, upper left, Guion S. Bluford, upper right; and Dale E. Gardner, all mission specialists.

  10. Powder pressing in a macrosonic field

    NASA Technical Reports Server (NTRS)

    Protipopescu, A.; Dragan, O.; Ciovica, D.

    1974-01-01

    An investigation was conducted to extend the technology of powder product manufacturing to new forms and sizes, to improve their quality as well as pressing efficiency and to reduce waste. In the course of metal and nonmetal powder briquette pressing, macrosounds were associated with the external static pressing force, which led to an increase in the relative height, density and physicomechanical characteristics of the briquettes. This method permits the extension of the range of products that can be manufactured from powders and the improvement of their quality.

  11. Course Does a Critical Study of Press in Capitalist Society.

    ERIC Educational Resources Information Center

    Winter, James

    1986-01-01

    Describes a course that documents in often laborious and relatively uncritical detail the history of the Canadian press and its American and British antecedents. Describes a course on the contemporary press consisting of various forms of press criticism. (HTH)

  12. Footprints of the EADV: a meeting report from the 17th Congress of the European Academy of Dermatology and Venereology.

    PubMed

    Alexandroff, A B; Burd, R

    2009-05-01

    The 17th Congress of the European Academy of Dermatology and Venereology took place in Paris on 17-20 September 2008 and brought together nearly 11,000 participants. Various plenary lectures, subspecialty meetings, 'free communications', 'top ten', 'test yourself' and 'junior' sessions, 19 courses and 14 'lunches with the expert', six forums, 27 symposia and 45 workshops were pressed into the 4 days of the meeting. Over 1700 posters were presented and exhibited. The themes of a number of symposiums, workshops and sessions overlapped, offering additional educational opportunities despite a very busy schedule. The meeting was well organized. Aesthetic dermatology comprised a significant part of the meeting. It is impossible to encompass all important presentations and we highlight a few medical pearls presented at the meeting; however, our report is not intended as a substitute for reading the conference proceedings and related references quoted in this article. PMID:19309366

  13. The Periplasmic Nitrate Reductase Nap Is Required for Anaerobic Growth and Involved in Redox Control of Magnetite Biomineralization in Magnetospirillum gryphiswaldense

    PubMed Central

    Li, Yingjie; Katzmann, Emanuel; Borg, Sarah

    2012-01-01

    The magnetosomes of many magnetotactic bacteria consist of membrane-enveloped magnetite crystals, whose synthesis is favored by a low redox potential. However, the cellular redox processes governing the biomineralization of the mixed-valence iron oxide have remained unknown. Here, we show that in the alphaproteobacterium Magnetospirillum gryphiswaldense, magnetite biomineralization is linked to dissimilatory nitrate reduction. A complete denitrification pathway, including gene functions for nitrate (nap), nitrite (nir), nitric oxide (nor), and nitrous oxide reduction (nos), was identified. Transcriptional gusA fusions as reporters revealed that except for nap, the highest expression of the denitrification genes coincided with conditions permitting maximum magnetite synthesis. Whereas microaerobic denitrification overlapped with oxygen respiration, nitrate was the only electron acceptor supporting growth in the entire absence of oxygen, and only the deletion of nap genes, encoding a periplasmic nitrate reductase, and not deletion of nor or nos genes, abolished anaerobic growth and also delayed aerobic growth in both nitrate and ammonium media. While loss of nosZ or norCB had no or relatively weak effects on magnetosome synthesis, deletion of nap severely impaired magnetite biomineralization and resulted in fewer, smaller, and irregular crystals during denitrification and also microaerobic respiration, probably by disturbing the proper redox balance required for magnetite synthesis. In contrast to the case for the wild type, biomineralization in Δnap cells was independent of the oxidation state of carbon substrates. Altogether, our data demonstrate that in addition to its essential role in anaerobic respiration, the periplasmic nitrate reductase Nap has a further key function by participating in redox reactions required for magnetite biomineralization. PMID:22730130

  14. The napF and narG Nitrate Reductase Operons in Escherichia coli Are Differentially Expressed in Response to Submicromolar Concentrations of Nitrate but Not Nitrite

    PubMed Central

    Wang, Henian; Tseng, Ching-Ping; Gunsalus, Robert P.

    1999-01-01

    Escherichia coli synthesizes two biochemically distinct nitrate reductase enzymes, a membrane-bound enzyme encoded by the narGHJI operon and a periplasmic cytochrome c-linked nitrate reductase encoded by the napFDAGHBC operon. To address why the cell makes these two enzymes, continuous cell culture techniques were used to examine napF and narG gene expression in response to different concentrations of nitrate and/or nitrite. Expression of the napF-lacZ and narG-lacZ reporter fusions in strains grown at different steady-state levels of nitrate revealed that the two nitrate reductase operons are differentially expressed in a complementary pattern. The napF operon apparently encodes a “low-substrate-induced” reductase that is maximally expressed only at low levels of nitrate. Expression is suppressed under high-nitrate conditions. In contrast, the narGHJI operon is only weakly expressed at low nitrate levels but is maximally expressed when nitrate is elevated. The narGHJI operon is therefore a “high-substrate-induced” operon that somehow provides a second and distinct role in nitrate metabolism by the cell. Interestingly, nitrite, the end product of each enzyme, had only a minor effect on the expression of either operon. Finally, nitrate, but not nitrite, was essential for repression of napF gene expression. These studies reveal that nitrate rather than nitrite is the primary signal that controls the expression of these two nitrate reductase operons in a differential and complementary fashion. In light of these findings, prior models for the roles of nitrate and nitrite in control of narG and napF expression must be reconsidered. PMID:10464201

  15. Apollo 13 Facts [Post Flight Press Conference

    NASA Technical Reports Server (NTRS)

    2001-01-01

    The Apollo 13 astronauts, James Lovell, Jr., John Swigert, Jr., and Fred Haise, Jr., are seen during this post flight press conference. They describe their mission and answer questions from the audience.

  16. Student Press Law: What Lies Ahead?

    ERIC Educational Resources Information Center

    Eveslage, Thomas

    1980-01-01

    Assesses recent developments in student press rights in the areas of prior restraint, libel and obscenity, and material and substantial disruption, and predicts future trends in student rights litigation. (TJ)

  17. Gas-driven filter pressing in magmas

    USGS Publications Warehouse

    Sisson, T.W.; Bacon, C.R.

    1999-01-01

    Most silicic and some mafic magmas expand via second boiling if they crystallize at depths of about 10 km or less. The buildup of gas pressure due to second boiling can be relieved by expulsion of melt out of the region of crystallization, and this process of gas-driven filter pressing assists the crystallization differentiation of magmas. For gas-driven filter pressing to be effective, the region of crystallization must inflate slowly relative to buildup of pressure and expulsion of melt These conditions are satisfied in undercooled magmatic inclusions and in thin sheets of primitive magma underplating cooler magma reservoirs. Gas-driven filter pressing thereby adds fractionated melt to magma bodies. Gas-driven filter pressing is probably the dominant process by which highly evolved melts segregate from crystal mush to form aplitic dikes in granitic plutons; this process could also account for the production of voluminous, crystal-poor rhyolites.

  18. Thermal Conductances of Pressed Copper Contacts

    NASA Technical Reports Server (NTRS)

    Salerno, L.; Kittel, P.; Spivak, A.

    1986-01-01

    Report describes investigation of thermal conductivities of smooth copper contacts pressed together at liquid-helium temperatures. Investigation prompted by need for accurate thermal models for infrared detectors and other cryogenic instruments.

  19. The Place of the Humanities at a Military Academy

    ERIC Educational Resources Information Center

    Flammang, Lucretia A.

    2007-01-01

    The author, a captain in the U.S. Coast Guard and professor of English at the Coast Guard Academy in New London, Connecticut, argues in this article that, contrary to images perpetuated in popular culture, military officers do not eschew the arts as exemplified in such films as "Platoon" and "Full Metal Jacket" where the audience is expected to…

  20. Teaching Psychology at the United States Military Academy.

    ERIC Educational Resources Information Center

    Beach, Johnston

    Psychology instruction through the Department of Behavioral Sciences and Leadership at the U.S. Military Academy, West Point, is described, along with faculty development and teaching philosophy. Courses offered by the department are part of an integrated curriculum in the behavioral sciences, with the central focus being leadership development.…

  1. KIPP DIAMOND Academy: Year Three (2004-2005) Evaluation Report

    ERIC Educational Resources Information Center

    Thompson, Susan, McDonald, Aaron; Sterbinsky, Allan

    2005-01-01

    The KIPP (Knowledge Is Power Program) Diamond (Daring Individual Achievers Making Outstanding New Dreams) Academy, housed in Cypress Junior High School in Memphis, Tennessee, opened in the summer of 2002. KIPP goals include enhancement of academic achievement and promotion of positive student leadership through an innovative redesign of…

  2. KIPP DIAMOND Academy Year Three (2004-2005) Evaluation Report

    ERIC Educational Resources Information Center

    Thompson, Susan; McDonald, Aaron; Sterbinsky, Allan

    2005-01-01

    The purpose of the present evaluation study was to examine the progress made in program implementation, school climate, and student achievement by the KIPP (Knowledge Is Power Program) DIAMOND (Daring Individual Achievers Making Outstanding New Dreams) Academy (KIPP:DA) housed in Cypress Junior High School in Memphis, Tennessee. The school began…

  3. Hand's Academy Challenge: Some Starter Questions

    ERIC Educational Resources Information Center

    Gardner, Peter

    2014-01-01

    Michael Hand has recently challenged certain religious organisations that run Academies in the United Kingdom to devise and pursue their own faith-based curricula in their schools. In this short article I examine some of the problems Hand's challenge might encounter, including whether religious conceptions of worthwhile activities and of…

  4. The National Insurance Academy: Serving India's Insurance Professionals and Researchers

    ERIC Educational Resources Information Center

    Sane, Bhagyashree

    2011-01-01

    This article discusses how a special library can meet the needs of a specific industry. The author focuses on India's National Insurance Academy (NIA) Library, which serves the insurance industry of India and some neighboring countries. It is where the author serves as the chief librarian.

  5. Career Academies: Impacts on Labor Market Outcomes and Educational Attainment

    ERIC Educational Resources Information Center

    Kemple, James J.

    2004-01-01

    Career Academies offer high schools--particularly those in urban communities that struggle to keep students in school and to prepare them for post-secondary education and employment opportunities--a systematic approach to addressing a range of challenges. Typically serving between 150 and 200 students from grades 9 or 10 through grade 12, Career…

  6. The Role of the Humanities in Decolonising the Academy

    ERIC Educational Resources Information Center

    Prinsloo, Estelle H.

    2016-01-01

    This short paper argues that the #RhodesMustFall movement, which originated at the University of Cape Town, has brought renewed attention to the need to decolonise the academy in South Africa. It further argues that the Humanities are ideally placed to engage with the intellectual problems and questions presented by the decolonisation debate. Deep…

  7. Northeast Ohio Principals Academy Pilot Entry Year Program Evaluation Report.

    ERIC Educational Resources Information Center

    Trenta, Louis; Covrig, Duane

    This evaluation determined the workability of the Northeast Ohio Principals Academy Pilot Entry Year Program, noting the differential effects of its major components in developing portfolios and as a contributing factor to school improvement. The program provides leadership and support to beginning principals, provides collaborative learning…

  8. The Role of Career Academies in Education Improvement

    ERIC Educational Resources Information Center

    Hyslop, Alisha

    2009-01-01

    ACTE Issue Briefs provide background information, highlight research, profile career and technical education (CTE) programs and include examples of how CTE is tied to a broader issue of national interest. This brief, "The Role of Career Academies in Education Improvement," was released in the spring of 2009 to capitalize on education reform…

  9. Undergraduate Astronautics at the United States Naval Academy.

    ERIC Educational Resources Information Center

    Bagaria, William J.

    1991-01-01

    The aerospace engineering curriculum at the U.S. Naval Academy which includes an astronautical and an aeronautical track is described. The objective of the program is to give students the necessary astronautical engineering background to perform a preliminary spacecraft design during the last semester of the program. (KR)

  10. 75 FR 54086 - Global Intellectual Property Academy Program Survey

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-03

    ... Patent and Trademark Office Global Intellectual Property Academy Program Survey ACTION: Proposed... following methods: E-mail: InformationCollection@uspto.gov . Include ``0651- 00xx Global Intellectual... information should be directed to the attention of J. David Binsted, Program Manager, Global...

  11. Schools "Flip" for Lesson Model Promoted by Khan Academy

    ERIC Educational Resources Information Center

    Sparks, Sarah D.

    2011-01-01

    The author reports on a "flip model" of instruction that has gotten national media attention lately, thanks to its promotion by Khan Academy, the high-profile nonprofit online-tutoring library created by Salman A. Khan, a Massachusetts Institute of Technology graduate who was looking for a way to help his young relatives with their homework. The…

  12. At Home in the Academy: Latina Faculty Counterstories and Resistances

    ERIC Educational Resources Information Center

    Oliva, Maricela; Rodriguez, Mariela A.; Alanis, Iliana; Quijada Cerecer, Patricia D.

    2013-01-01

    In the Academy, faculty and institutional leaders traditionally have been white, male, and heterosexual. Of the 173,395 Full Professors identified in the Integrated Postsecondary Education Data System (IPEDS) of the U.S. Department of Education in 2007, women represented almost 46,000, and Latinas held only 1,254 of those positions (U.S.…

  13. West Virginia University's Health Sciences and Technology Academy

    ERIC Educational Resources Information Center

    Chester, Ann; Dooley, Elizabeth

    2011-01-01

    This article describes the Health Sciences and Technology Academy, an outreach and engagement program by West Virginia University to encourage higher education faculty members and administrators, public school teachers, and community leaders to assume the responsibility of mentoring high school students. The primary goal is to increase the college…

  14. Second Chances Academy: Alternative School or Pathway to Prison?

    ERIC Educational Resources Information Center

    Horsford, Sonya Douglass; Powell, Keyona L.

    2016-01-01

    This case considers the leadership challenge facing district officials in a mid-sized urban-suburban school district receiving negative media coverage for the overrepresentation of poor, Black, and Latino males in its alternative high school, Second Chances Academy. Many of its students also qualify for special education and English learner…

  15. The Leadership Practices of the Dean of Combined Arms Academy

    ERIC Educational Resources Information Center

    Tafere, Matebe

    2014-01-01

    This study is on the leadership practices of the dean of Combined Army Academy. The research is a qualitative design. The academic staff members were the participants of the study. Formal and informal conversational interview approaches, personal observation and document analysis were the instruments of the study. Thematic analysis was used for…

  16. Victims Deserve More: The Building of a Forensics Academy

    ERIC Educational Resources Information Center

    Johnson, Lili K.

    2007-01-01

    Because victims deserve more, The American Academy of Applied Forensics at Central Piedmont Community College was created to link cutting-edge forensics research to its field applications. It does this by enhancing the knowledge, skill, and ability levels of crime scene investigators, thereby increasing the likelihood that truth will be revealed…

  17. Undergraduate Design Learning in Multiple Partnerships: For Academies

    ERIC Educational Resources Information Center

    Butcher, John; Schaber, Friedemann

    2013-01-01

    This article reports research into undergraduate design learning through an off-campus partnership. The Sorrell Foundation's Joinedupdesign for Academies programme involved partnerships between university design departments, "failing" 11-18 schools and professional designers, in the context of a funding commitment to rebuild/renew…

  18. Performatively Queer: Sole Parent Postgraduates in the Australian Academy

    ERIC Educational Resources Information Center

    Hook, Genine A.

    2015-01-01

    This paper draws on research that considers how gender and agency influence the engagement of sole parent postgraduates within the Australian academy. I argue that parental care responsibilities critically influence participation in higher education for sole parents. I suggest that the gendered construct of caring for children is a feminine…

  19. Faculty Unions, Business Models, and the Academy's Future

    ERIC Educational Resources Information Center

    Rhoades, Gary

    2011-01-01

    In this article, the author addresses questions about the future of faculty unions, business models, and the academy by providing some current and historical context regarding the causes of and conflicts about faculty unions. He also reviews trends in college and university management over the past three decades, using California, Ohio, and…

  20. Further Reflections on the Great City Academy Fraud

    ERIC Educational Resources Information Center

    Beckett, Francis

    2008-01-01

    Academy sponsors have generally behaved with great arrogance, knowing that they enjoyed the enthusiastic support of Tony Blair's Government. And this has been particularly true of Catholic and evangelical sponsors, who believed that Blair's premiership was the best chance they would ever have of bringing about a seismic shift of power in schools…

  1. Navigating Orientalism: Asian Women Faculty in the Canadian Academy

    ERIC Educational Resources Information Center

    Mayuzumi, Kimine

    2015-01-01

    While individuals of note have been documented, there has been a paucity of research into the collective voices of Asian women faculty in higher education. To fill this gap, the study brings forward the narratives of nine Asian women faculty members in the Canadian academy who have roots in East Asia. Employing the concept of Orientalism within a…

  2. The CUNY Fatherhood Academy: A Qualitative Evaluation. Executive Summary

    ERIC Educational Resources Information Center

    McDaniel, Marla; Simms, Margaret C.; Monson, William; de Leon, Erwin

    2015-01-01

    Knowing the economic challenges young fathers without postsecondary education face in providing for their families, New York City's Young Men's Initiative launched a fatherhood program housed in LaGuardia Community College in spring 2012. The CUNY Fatherhood Academy (CFA) aims to connect young fathers to academic and employment opportunities while…

  3. Personal Problems of Seventh-Day Adventist Academy Students

    ERIC Educational Resources Information Center

    Crosby, Ellen; Freed, Shirley; Gabriel, Elvin

    2006-01-01

    The Personal Problems Checklist for Adolescents (PPC-A) was administered to students in 14 Adventist academies for the purpose of determining the extent of their personal problems. Descriptive and inferential statistics were used to analyze the data. The results showed that the top 10 problems were: (1) poor study habits; (2) worrying about future…

  4. Personality Traits of Police Cadets: Relationship to Academy Performance.

    ERIC Educational Resources Information Center

    Topp, Bruce W.; Kardash, Carol Anne

    A study examined the relationship of the personality traits of 94 police cadets to their performance at a southwestern state law enforcement academy. The overall training success (percentage of total points earned) of recruits enrolled in 11 weeks of on-site training classes was the primary criterion of the study, and raw personality factor scores…

  5. A Proposed E-Learning Policy Field for the Academy

    ERIC Educational Resources Information Center

    Parchoma, Gale

    2006-01-01

    In this article, Lewin's (1951) social field theory is used as a framework for analyzing the potential for implementing scalable and sustainable e-learning initiatives in the academy. Powerful external economic and social forces coming to bear on academic leadership decisions are considered. The impacts of the emergence of the global learning…

  6. Specialist Schools and Academies Trust Annual Report, 2009-2010

    ERIC Educational Resources Information Center

    Schools Network, 2010

    2010-01-01

    The Specialist Schools and Academies Trust (SSAT) is an independent, not-for-profit membership organisation dedicated to raising levels of achievement in education. SSAT has a membership of over 5,500 schools and growing numbers of affiliated universities, colleges and local authorities. This 2009/2010 Annual Report shows clearly the practical …

  7. Remember 9-11! White Belligerency in the Academy

    ERIC Educational Resources Information Center

    Valandra, Edward C.

    2003-01-01

    This author states that, although white belligerency is not new, it exists in a ubiquitous low to midlevel state. As nonwhite experiences reveal and the white historical record distinctly shows, there has been an ongoing controversy over a whole host of issues within the academy that involve the Color Line, like a racially separate but unequal…

  8. The Agony or the Ecstasy? The Academy at the Crossroads.

    ERIC Educational Resources Information Center

    Wheal, James R.

    2000-01-01

    Contemporary schooling, particularly high schools, could benefit from a return to the model of Plato's Academy in which ecstatic experience provided a central and informative role in addressing the higher stages of human development. Supplementing traditional curricula with integral practices that address body, mind, and spirit, and reviving the…

  9. When the Corporate Storm Strikes the Academy: Faculty Response Required

    ERIC Educational Resources Information Center

    DeBoy, James L.

    2015-01-01

    When the corporate storm strikes the academy, faculty must be willing and able to repel administrative assaults upon academic freedom, shared governance, and tenure. This paper will describe the on-going clash between administrators who embrace the corporate mindset and faculty who cherish traditions of shared governance and collegial…

  10. Improving the Status of Women in the Academy

    ERIC Educational Resources Information Center

    Gee, Michele V.; Norton, Sue Margaret

    2009-01-01

    While women have always faced gender inequities in the general workplace, the academic world has traditionally prided itself on equality and transparency. Sadly, despite substantial gains in the number of doctorates awarded to women and in their employment in academic institutions, there is still much room for improvement in the academy. The…

  11. School 2.0: The Science Leadership Academy

    ERIC Educational Resources Information Center

    Lehmann, Christopher

    2007-01-01

    This article features the Science Leadership Academy, a new public partnership school in Philadelphia that incorporates core values of inquiry, research, collaboration, presentation, and reflection. Founded by the School District of Philadelphia and The Franklin Institute, SLA is one of four partnership high schools that opened in September 2006…

  12. 75 FR 21223 - National Academy of Sciences Study

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-23

    ... From the Federal Register Online via the Government Publishing Office CHEMICAL SAFETY AND HAZARD INVESTIGATION BOARD National Academy of Sciences Study AGENCY: Chemical Safety and Hazard Investigation Board... Chemical Safety and Hazard Investigation Board (CSB) provides funding for a study by the National...

  13. Implementing Ninth Grade Academies in Broward County, Florida

    ERIC Educational Resources Information Center

    Legters, Nettie; Parise, Leigh; Rappaport, Shelley

    2013-01-01

    Researchers from MDRC and Johns Hopkins University partnered with Florida's Broward County Public Schools (BCPS) in 2009 to launch an independent evaluation of the district's initiative to implement Ninth Grade Academies (NGAs) in every district high school. An NGA is a self-contained learning community for ninth-graders that operates as…

  14. Enhancing Literacy for Jobs and Productivity. Academy Final Report.

    ERIC Educational Resources Information Center

    Chynoweth, Judith K.

    This document reports how the Council of State Policy and Planning Agencies (CSPA) Academy process helped nine states develop workplace literacy initiatives involving their governors' offices, the Job Training Partnership Act system, and the educational system. The states were Florida, Idaho, Massachusetts, Michigan, North Carolina, Tennessee,…

  15. Leading the Academy or Being Led? Hong Kong Women Academics

    ERIC Educational Resources Information Center

    Aiston, Sarah Jane

    2014-01-01

    This paper provides a new gender-based analysis of survey data collected on Hong Kong academics in 2008. First, it illustrates the gender differences that exist in the Hong Kong academy. Second, it discusses possible explanations for these differences as informed by the data. And third, it offers a novel argument, again informed by the data, for…

  16. Program Development Trends and Issues: The Cleveland Leadership Academy.

    ERIC Educational Resources Information Center

    Crisci, Pat Eva; Tutela, Alfred D.

    This paper focuses on public school program development to correct the effects of segregation. It suggests concrete measures and plans for the Cleveland Leadership Academy, which is designed to enhance instruction and access. Cleveland City School District's Remedial Order is a court-approved blueprint for desegregation that mandated management…

  17. The CUNY Fatherhood Academy: A Qualitative Evaluation. Research Report

    ERIC Educational Resources Information Center

    McDaniel, Marla; Simms, Margaret C.; Monson, William; de Leon, Erwin

    2015-01-01

    Knowing the economic challenges young fathers without postsecondary education face in providing for their families, New York City's Young Men's Initiative launched a fatherhood program housed in LaGuardia Community College in spring 2012. The CUNY Fatherhood Academy (CFA) aims to connect young fathers to academic and employment opportunities while…

  18. Rethinking Leadership in the Academy: An Australian Case

    ERIC Educational Resources Information Center

    Bianchini, Stefano; Maxwell, Tudor; Dovey, Ken

    2014-01-01

    As with higher education institutions in other Organisation for Economic Cooperation and Development countries, Australian universities are facing significant challenges. One particular challenge is that of the declining quality of the teaching and learning experience within the academy. This paper describes an attempt to sustain the quality of a…

  19. The School Academies Programme: A New Direction or Total Abandonment?

    ERIC Educational Resources Information Center

    Chitty, Clyde

    2008-01-01

    The concept of City Academies owes much to the plan for a network of City Technology Colleges announced by Conservative Education Secretary Kenneth Baker in 1986. This article argues that all this can be viewed as part of the inroad of business into state education, with private sponsorship seen by government as the magical solution to the…

  20. A Day in the Life at DaVita Academy

    ERIC Educational Resources Information Center

    Weinstein, Margery

    2010-01-01

    When a company name means "giving life," the bar for learning and development programs is held high. In this article, the author describes what it takes to graduate from DaVita Academy, the soft skills training program dialysis services company DaVita offers all its employees. DaVita's chief executive officer, Kent Thiry, states that the Academy…

  1. The French Academy: Arbitrator of Taste, Order, Genius--Immortality.

    ERIC Educational Resources Information Center

    Buzash, Michael D.

    The French Academy is the oldest of the scholarly societies of France. Its ideals and preferences of order, genius, and immortality have influenced the schools, conservatories, universities, and archives and the intellectual and artistic tastes of the time. Its foundation was laid by nine lettered, well-educated laymen and ecclesiastics around…

  2. The links between medical school of Bologna and Ionian Academy.

    PubMed

    Lascaratos, J; Marketos, S

    1989-01-01

    The Ionian Academy, on the British dominion island of Corfu (Kerkyra), was founded in 1824 and his Medical School functioned during two separate periods (1824-1828, 1844-1865). It was the first Greek University. Among the 15 professors of the Academy's Medical School, 12 studied at various Italian universities. In particular, three of them, G. Therianos, Professor of Comparative Anatomy and Experimental Physics, G. Grassetti, Professor of Physiology and S. Arvanitakis, Professor of Pathology and Hygiene, either studied or graduated at the Medical school of Bologna University. Another Bologna graduate, Rokkos Pylarios, was appointed to the chair of Professor in Surgery and Gynecology - though it is not known if he actually took up the position. It is concluded that the Medical School of Bologna, as a centre of original medical study, contributed significantly to the foundation and development of the Ionian Academy. Moreover, the Greek physicians who had studied either at the University of Bologna or at the Ionian Academy, contributed to the renaissance of neohellenic medicine during the 19th century. PMID:11640087

  3. Teaching and Learning Resources: Curriculum Guide for Career Academies.

    ERIC Educational Resources Information Center

    Raby, Marilyn; Markham, Thom; Lenz, Bob; Ryan, Tricia

    This document profiles a total of 78 resources to assist individuals responsible for development and implementation of career academies. The resources are organized into sections that are each devoted to one of the following types of information resources: information indexes; search engines; World Wide Web portals for education; lesson plan…

  4. The Case: Bunche-Da Vinci Learning Partnership Academy

    ERIC Educational Resources Information Center

    Eisenberg, Nicole; Winters, Lynn; Alkin, Marvin C.

    2005-01-01

    The Bunche-Da Vinci case described in this article presents a situation at Bunche Elementary School that four theorists were asked to address in their evaluation designs (see EJ791771, EJ719772, EJ791773, and EJ792694). The Bunche-Da Vinci Learning Partnership Academy, an elementary school located between an urban port city and a historically…

  5. Academy Conversion: A View from the Governing Body

    ERIC Educational Resources Information Center

    Gann, Nigel

    2011-01-01

    The case for conversion to academy status is being made in a number of arenas, not least on the Department for Education website. As a matter of balance, school governors considering conversion need to take into account a range of factors. How does this fundamental shift in the ownership of schools fit into a discernible historical pattern?…

  6. The Prussian Academy of Sciences during the Third Reich

    ERIC Educational Resources Information Center

    Notzoldt, Peter; Walther, Peter Th.

    2004-01-01

    In 1933, the Prussian Academy of Sciences and Humanities was an exclusive learned society, out of touch with modern methods and funding, which had also failed to re-establish itself as a "centre of research". During the Nazi regime, it was at best peripherally involved in the restructuring of German academia. While some of its members played a…

  7. American Academy of Otolaryngology--Head and Neck Surgery

    MedlinePlus

    ... Program offers experience reviewing scholarly articles in Otolaryngology–Head and Neck Surgery to PGY-2 residents and above. Receive ... Log in © Copyright 2016. American Academy of Otolaryngology — Head and Neck Surgery 1650 Diagonal Rd Alexandria, VA 22314-2857 ...

  8. A Contentious Triangle: Grading and Academic Freedom in the Academy

    ERIC Educational Resources Information Center

    Hill, Duncan

    2011-01-01

    This article examines the tensions created by academic freedom and grading in universities between academic staff and academic administration. Additionally, the impact of grading and academic standards on students' academic freedom is addressed, as well as the impact of corporatisation in the academy. By reviewing the existing literature and case…

  9. [Lancisi, Baglivi and the medical academies in Rome].

    PubMed

    Angeletti, L R

    2000-01-01

    Many medical academies were active in Rome during the 17th century; they were promoted by noble patrons, ecclesiastics or eminent physicians, and equipped with libraries. Their role was important in the spreading of the new biomedical thought, founded on the comparison between ideas and experimental data. As an epistemological heritage of Marcello Malpighi and as a connection to the new scientific European ideas, Baglivi directed his efforts towards a leading role of the experimental observations, whereas his predecessor Lancisi was bound to the theorical "ipse dixit" role of the masters of medicine. The analysis of the statutes of the Roman Academies bring to light the new experimentalism, due to the "virtuosi" (vituous men) and "curiosoni" (inquisitive/odd persons) of the Academies: Baglivi, in his De praxi medica, invites the princes to establish in every Metropolitan Hospital an Academy - Medicorum Collegium, in which discussion on clinical aspects should be performed: extraordinary importance is devoted to the epistemological difference between "experientia" (guided in the profession by a membrum - litteratum, thought the direct comparison on the texts) and "experimentum" (following the clinical observation, guided by a membrum historicum-practicum). PMID:11624715

  10. The Status Gap: Female Faculty in the Legal Academy

    ERIC Educational Resources Information Center

    Monopoli, Paula A.

    2014-01-01

    Status in the legal academy can mean two things. The first is one's rank, with the highest status being a tenured, full professor. The second is the prestige of one's home institution in the law school rankings. Women have been graduating from law schools in significant numbers for more than thirty years. However, they continue to be…

  11. Biallelic expression of Tssc4, Nap1l4, Phlda2 and Osbpl5 in adult cattle.

    PubMed

    Wang, Mengnan; Li, Dongjie; Zhang, Mingyue; Yang, Wenzhi; Wu, Guojiang; Cui, Yali; Li, Shijie

    2015-09-01

    Genomic imprinting of the Cdkn1c/Kcnq1ot1 region shows lack of conservation between human and mouse. This region has been reported to be associated with Beckwith-Wiedemann syndrome (BWS) and cancer. To increase our understanding of imprinted genes in bovine Cdkn1c/Kcnq1ot1 imprinting cluster, we assessed the imprinting status of four cattle genes (Tssc4,Nap1l4, Phlda2 and Osbpl5) in seven types of tissues: heart, liver, spleen, lung, kidney, skeletal muscle and subcutaneous fat using polymorphism-based sequencing approach. It was found that all the four genes showed biallelic expression in tissues in which transcripts were detected. Nap1l4 and Tssc4 were detected in all examined tissues, while the expression of Phlda2 and Osbpl5 was tissue-specific. Phlda2 was not detected in heart and subcutaneous fat, and Osbpl5 was not detected in spleen and skeletal muscle. In addition, identification of species-specific imprinted genes is necessary to understand the evolution of genomic imprinting and to elucidate mechanisms leading to allele-specific expression. PMID:26440077

  12. Heterodimeric nitrate reductase (NapAB) from Cupriavidus necator H16: purification, crystallization and preliminary X-ray analysis

    SciTech Connect

    Coelho, Catarina; González, Pablo J.; Trincão, José; Carvalho, Ana L.; Najmudin, Shabir; Moura, José J. G.; Moura, Isabel; Romão, Maria J.

    2007-06-01

    Crystals of the oxidized form of the periplasmic nitrate reductase from Cupriavidus necator were obtained using polyethylene glycol 3350 as precipitant The periplasmic nitrate reductase from Cupriavidus necator (also known as Ralstonia eutropha) is a heterodimer that is able to reduce nitrate to nitrite. It comprises a 91 kDa catalytic subunit (NapA) and a 17 kDa subunit (NapB) that is involved in electron transfer. The larger subunit contains a molybdenum active site with a bis-molybdopterin guanine dinucleotide cofactor as well as one [4Fe–4S] cluster, while the small subunit is a di-haem c-type cytochrome. Crystals of the oxidized form of this enzyme were obtained using polyethylene glycol 3350 as precipitant. A single crystal grown at the High Throughput Crystallization Laboratory of the EMBL in Grenoble diffracted to beyond 1.5 Å at the ESRF (ID14-1), which is the highest resolution reported to date for a nitrate reductase. The unit-cell parameters are a = 142.2, b = 82.4, c = 96.8 Å, β = 100.7°, space group C2, and one heterodimer is present per asymmetric unit.

  13. The influence of daytime napping versus controlled activity on the subjective well-being of patients with major depression.

    PubMed

    Peth, Judith; Regen, Francesca; Bajbouj, Malek; Heuser, Isabella; Anghelescu, Ion; Hornung, Orla Patricia

    2012-12-30

    While the impact of sleep on cognitive functions such as memory is under extensive study, the role of sleep in modulating a persons' subjective well-being remains largely uncharacterized, especially in groups with psychiatric disorders. To gather more information on this topic a study was conducted with 20 patients suffering from Major Depression (MD) and 20 healthy controls, matched for age, gender and education. All subjects rated their subjective well-being at 10a.m. in the morning. Half of the subjects in each experimental group were given the opportunity to nap in the afternoon between 2p.m. and 3.30p.m., while the other half stayed awake accompanied by controlled activity. All subjects rated their subjective well-being again at 4p.m. Only the group of patients with MD who were given the opportunity to sleep during the day showed a significant improvement in subjective well-being from morning to afternoon. All the other subgroups showed no significant changes across the time interval. The results of this study suggest that depressive patients benefit from daytime naps with regard to their subjective well-being. Further research is needed to determine the exact mechanisms of this improvement. PMID:22789840

  14. New insights into alkylammonium-functionalized clinoptilolite and Na-P1 zeolite: Structural and textural features

    NASA Astrophysics Data System (ADS)

    Muir, Barbara; Matusik, Jakub; Bajda, Tomasz

    2016-01-01

    The area of zeolites' application could be expanded by utilizing their surfaces. Zeolites are frequently modified to increase their hydrophobicity and to generate the negative charge of the surface. The main objective of the study was to investigate and compare the features of natural clinoptilolite and synthetic zeolite Na-P1 modified by selected surfactants involving quaternary ammonium salts. The FTIR study indicates that with increasing carbon chain length in the surfactant attached to the zeolites surface the molecules adopt a more disordered structure. FTIR was also used to determine the efficiency of surface modification. Thermal analysis revealed that the presence of surfactant results in additional exothermic effects associated with the breaking of electrostatic bonds between zeolites and surfactants. The mass losses are in line with ECEC and CHN data. The textural study indicates that the synthetic zeolite Na-P1 has better sorption properties than natural clinoptilolite. The modification process always reduces the SBET and porosity of the material. With an increasing carbon chain length of surfactants all the texture parameters decrease.

  15. Rigor and academic achievement: Career academies versus traditional class structure

    NASA Astrophysics Data System (ADS)

    Kyees, Linda L.

    The purpose of this study was to determine if students who attended high school Career Academy classes, as part of Career and Technical Education, showed greater academic achievement than students who attended traditional high school classes. While all participants attended schools in the same school district, and were seeking the same goal of graduation with a standard diploma, the Career Academy students had the benefit of all classes being directed by a team of teachers who helped them connect their learning to their desired career through collaborative learning projects and assignments. The traditional high school classes taught each subject independent of other subjects and did not have specific connections to desired career goals of the students. The study used a causal-comparative research design and the participants included 1,142 students from 11th and 12th grades who attended 9 high schools in a diversely populated area of central Florida with 571 enrolled in the Career Academies and 571 enrolled in traditional classes. The 10th-grade FCAT scores served as the dependent variable. All students attended similar classes with similar content, making the primary variable the difference in academic gains between students participating in the Career Academy design and the traditional design classes. Using the Man-Whitney U Test resulted in the Career Academy group achieving the higher scores overall. This resulted in rejection of the first null-hypothesis. Further examination determined that the 10th-grade FCAT scores were greater for the average students group, which comprised the largest portion of the participant group, also resulted in rejection of the second null-hypothesis. The gifted and at-risk student group scores resulted in failure to reject the third and fourth null-hypotheses.

  16. 75 FR 37780 - Proposed Waivers and Extensions of Project Periods: Presidential Academies and Congressional...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-30

    ... they apply to projects funded under the Presidential Academies for American History and Civics... for Students of American History and Civics Education. These regulations, respectively, generally... five-year grants funded under the Presidential Academies for American History and Civics...

  17. A Study of Attrition of U.S. Coast Guard Academy Cadets and Junior Officers Who Are Academy Graduates.

    ERIC Educational Resources Information Center

    Enger, Isadore; And Others

    The objective was to improve procedures for selecting entrants with better potential for (a) completing the Coast Guard Academy and (b) remaining on active duty after graduation beyond the mandatory five-year period. Stepwise multiple regression was applied to the information on 10 instruments to develop equations for predicting graduation. Five…

  18. From the National Academies: A Tribute to the Science Education Legacy of National Academy of Sciences President Bruce Alberts

    ERIC Educational Resources Information Center

    Labov, Jay B.

    2005-01-01

    This column, "From the National Academies," was Bruce Alberts' idea, one of so many for improving education. As a long-standing member of the American Society for Cell Biology, the namesake for the prize that is awarded annually to cell biologists for excellence in science education, and one of the founding editors of this journal, Alberts…

  19. New Members and Foreign Associates Elected to the National Academy of Sciences on May 2, 2000

    PubMed Central

    2000-01-01

    The Academy has elected 60 new members and 15 foreign associates from 9 countries in recognition of their distinguished and continuing achievements in original research. The election was held during the business session of the 137th annual meeting of the Academy. Election to membership in the Academy is considered one of the highest honors that can be accorded a U.S. scientist or engineer. Foreign associates are non-voting members of the Academy, with citizenship outside of the United States.

  20. Implementing Career Academies in Florida: A Case Study Approach to Understanding Successes and Obstacles

    ERIC Educational Resources Information Center

    Dixon, Maressa L.; Cotner, Bridget A.; Wilson, Tasha-Neisha C.; Borman, Kathryn M.

    2011-01-01

    Recent legislation in Florida mandated that all school districts open at least one career academy by the 2008-2009 school-year, impacting career academy implementation dramatically. As the number of career academies in Florida increases, ensuring success requires attention to the complexities of implementation. Qualitative research conducted with…

  1. The Politics of the Academies Programme: Natality and Pluralism in Education Policy-Making

    ERIC Educational Resources Information Center

    Gunter, Helen M.; McGinity, Ruth

    2014-01-01

    Our investigations into the politics of the Academies Programme in England have generated thinking that draws on data about the conversion process from two projects. We engage with an early City Academy that replaced two "failing" schools, and a recent Academy that replaced a "successful" high school. We deploy Hannah…

  2. Diversity and the Success of Entering Classes at the U.S. Service Academies. Research Brief

    ERIC Educational Resources Information Center

    Kirby, Sheila Nataraj

    2010-01-01

    The United States Military Academy (USMA) at West Point, the United States Air Force Academy (USAFA) at Colorado Springs, and the United States Naval Academy (USNA) at Annapolis provide tuition-free, four-year undergraduate education and prepare entrants to be officers of the U.S. military services. Graduates are commissioned as officers for a…

  3. The American Academy of Kinesiology and Physical Education, 1940-1984: Innovation, Introspection, Identity, and Involvement

    ERIC Educational Resources Information Center

    Jable, J. Thomas

    2006-01-01

    In 2005, the American Academy of Kinesiology and Physical Education reached its 75th anniversary. In celebration of this momentous occasion, this paper examines 44 years of the Academy's history from 1940 to 1984. During the 1940s, the Academy was engaged in the war effort. Then in the 1950s, it sought to define more precisely its role and…

  4. 76 FR 3617 - U.S. Air Force Academy Board of Visitors Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-20

    ... Department of the Air Force U.S. Air Force Academy Board of Visitors Notice of Meeting AGENCY: U.S. Air Force Academy Board of Visitors, DoD. ACTION: Meeting notice. SUMMARY: Pursuant to Section 9355, Title 10, United States Code (U.S.C.), the United States Air Force Academy (USAFA) Board of Visitors (BoV)...

  5. 78 FR 25289 - Board of Visitors for the National Fire Academy Teleconference

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-30

    ... SECURITY Federal Emergency Management Agency Board of Visitors for the National Fire Academy Teleconference... Advisory Committee Teleconference. SUMMARY: The Board of Visitors for the National Fire Academy (Board...: The Board of Visitors for the National Fire Academy will meet on Wednesday, May 15, 2013, from 1:30...

  6. 76 FR 36933 - Board of Visitors for the National Fire Academy

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-23

    ... SECURITY Federal Emergency Management Agency Board of Visitors for the National Fire Academy AGENCY... Federal Advisory Committee Meeting. SUMMARY: The Board of Visitors for the National Fire Academy (Board... Board The purpose of the Board is to review annually the programs of the National Fire Academy...

  7. 76 FR 6149 - National Fire Academy Board of Visitors; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-03

    ... SECURITY Federal Emergency Management Agency National Fire Academy Board of Visitors; Notice of Meeting... Advisory Committee Meeting. SUMMARY: The National Fire Academy Board of Visitors will meet on February 22... background documents or comments received by the National Fire Academy Board of Visitors, go to...

  8. 78 FR 59045 - Board of Visitors for the National Fire Academy

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-25

    ... SECURITY Federal Emergency Management Agency Board of Visitors for the National Fire Academy AGENCY... Committee Meeting. SUMMARY: The Board of Visitors for the National Fire Academy (Board) will meet on October... or comments received by the National Fire Academy Board of Visitors, go to...

  9. 78 FR 72094 - Board of Visitors for the National Fire Academy

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-02

    ... SECURITY Federal Emergency Management Agency Board of Visitors for the National Fire Academy AGENCY... Committee Meeting. SUMMARY: The Board of Visitors for the National Fire Academy (Board) will meet on... or comments received by the National Fire Academy Board of Visitors, go to...

  10. 76 FR 58028 - Board of Visitors for the National Fire Academy

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-19

    ... SECURITY Federal Emergency Management Agency Board of Visitors for the National Fire Academy AGENCY... Committee Meeting. SUMMARY: The Board of Visitors for the National Fire Academy (Board) will meet on October... Board The purpose of the Board is to review annually the programs of the National Fire Academy...

  11. Career Academies. Communities of Support for Students and Teachers: Emerging Findings from a 10-Site Evaluation.

    ERIC Educational Resources Information Center

    Kemple, James J.

    This report studies career academies to explore students' and teachers' experiences and to contrast them with those of their peers in regular high school environments. Data are from questionnaires, interviews, and observations of Academy and non-Academy students (835 and 686 respectively) and teachers (65 and 403 respectively). Chapter 2 describes…

  12. Commitment to Liberal Education at the United States Air Force Academy

    ERIC Educational Resources Information Center

    Enger, Rolf C.; Jones, Steven K.; Born, Dana H.

    2010-01-01

    Located just north of Colorado Springs, Colorado, the United States Air Force Academy (USAFA) is one of the nation's federally funded military service academies. With an enrollment of approximately 4,400 undergraduates, the academy offers an integrated four-year curriculum of academics, athletics, leadership and character development, military…

  13. The Negotiation and Articulation of Identity, Position and Ethos in Joint Church Academies

    ERIC Educational Resources Information Center

    Green, Elizabeth

    2014-01-01

    This paper summarises the key findings of a research project into the identity, position and ethos of jointly sponsored church academies. The research sought to investigate how joint church academies are situated within the field, how they relate to existing academies and the maintained church school sector and how they articulate their vision and…

  14. 76 FR 70980 - Meeting of the U.S. Naval Academy Board of Visitors

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-16

    ... Department of the Navy Meeting of the U.S. Naval Academy Board of Visitors AGENCY: Department of the Navy, DoD. ACTION: Notice of Partially Closed Meeting. SUMMARY: The U.S. Naval Academy Board of Visitors... Naval Academy. The executive session of this meeting from 11 a.m. to 12 p.m. on December 5, 2011,...

  15. 76 FR 27031 - Meeting of the U.S. Naval Academy Board of Visitors

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-10

    ... Department of the Navy Meeting of the U.S. Naval Academy Board of Visitors AGENCY: Department of the Navy, DoD. ACTION: Notice of Partially Closed Meeting. SUMMARY: The U.S. Naval Academy Board of Visitors... Naval Academy. The executive session of this meeting from 11 a.m. to 12 p.m. on June 6, 2011,...

  16. 77 FR 31591 - Meeting of the U.S. Naval Academy Board of Visitors

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-29

    ... Department of the Navy Meeting of the U.S. Naval Academy Board of Visitors AGENCY: Department of the Navy, DoD. ACTION: Notice of partially closed meeting. SUMMARY: The U.S. Naval Academy Board of Visitors... Naval Academy. The executive session of this meeting from 11:00 a.m. to 12:00 p.m. on June 11,...

  17. 76 FR 10341 - Meeting of the U.S. Naval Academy Board of Visitors

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-24

    ... Department of the Navy Meeting of the U.S. Naval Academy Board of Visitors AGENCY: Department of the Navy, DoD. ACTION: Notice of partially closed meeting. SUMMARY: The U.S. Naval Academy Board of Visitors... Naval Academy. The executive session of this meeting from 11 a.m. to 12 p.m. on March 7, 2011,...

  18. 75 FR 51247 - Meeting of the U.S. Naval Academy Board of Visitors

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-19

    ... Department of the Navy Meeting of the U.S. Naval Academy Board of Visitors AGENCY: Department of the Navy, DoD. ACTION: Notice of Partially Closed Meeting. SUMMARY: The U.S. Naval Academy Board of Visitors... Naval Academy. The executive session of this meeting from 11 a.m. to 12 p.m. on September 13, 2010,...

  19. 77 FR 50090 - Meeting of the U.S. Naval Academy Board of Visitors

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-20

    ... Department of the Navy Meeting of the U.S. Naval Academy Board of Visitors AGENCY: Department of the Navy, DoD. ACTION: Notice of partially closed meeting. SUMMARY: The U.S. Naval Academy Board of Visitors... Naval Academy. The executive session of this meeting from 11 a.m. to 12 p.m. on September 10, 2012,...

  20. 77 FR 65870 - Meeting of the U.S. Naval Academy Board of Visitors

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-31

    ... Department of the Navy Meeting of the U.S. Naval Academy Board of Visitors AGENCY: Department of the Navy, DoD. ACTION: Notice of partially closed meeting. SUMMARY: The U.S. Naval Academy Board of Visitors... Naval Academy. The executive session of this meeting from 11:00 a.m. to 12:00 p.m. on December 3,...

  1. 75 FR 18167 - Meeting of the U.S. Naval Academy Board of Visitors

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-09

    ... Department of the Navy Meeting of the U.S. Naval Academy Board of Visitors AGENCY: Department of the Navy, DoD. ACTION: Notice of partially closed meeting. SUMMARY: The U.S. Naval Academy Board of Visitors... Naval Academy. The executive session of this meeting from 11 a.m. to 12 p.m. on June 28, 2010,...

  2. 78 FR 5424 - Meeting of the U.S. Naval Academy Board of Visitors

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-25

    ... Department of the Navy Meeting of the U.S. Naval Academy Board of Visitors AGENCY: Department of the Navy, DoD. ACTION: Notice of Partially Closed Meeting. SUMMARY: The U.S. Naval Academy Board of Visitors... Naval Academy. The executive session of this meeting from 11:00 a.m. to 12:00 p.m. on March 4,...

  3. 78 FR 53430 - Meeting of the U.S. Naval Academy Board of Visitors

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-29

    ... Department of the Navy Meeting of the U.S. Naval Academy Board of Visitors AGENCY: Department of the Navy, DoD. ACTION: Notice of partially closed meeting. SUMMARY: The U.S. Naval Academy Board of Visitors... Naval Academy. The executive session of this meeting from 11:00 a.m. to 12:00 p.m. on September 30,...

  4. 78 FR 29124 - Meeting of the U.S. Naval Academy Board of Visitors

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-17

    ... Department of the Navy Meeting of the U.S. Naval Academy Board of Visitors AGENCY: Department of the Navy, DoD. ACTION: Notice of partially closed meeting. SUMMARY: The United States Naval Academy Board of... Naval Academy. The executive session of this meeting from 11:00 a.m. to 12:00 p.m. on June 3, 2013,...

  5. 76 FR 54223 - Meeting of the U.S. Naval Academy Board of Visitors

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-31

    ... Department of the Navy Meeting of the U.S. Naval Academy Board of Visitors AGENCY: Department of the Navy, DoD. ACTION: Notice of partially closed meeting. SUMMARY: The U.S. Naval Academy Board of Visitors... Naval Academy. The executive session of this meeting from 11 a.m. to 12 p.m. on September 19, 2011,...

  6. 75 FR 68773 - Meeting of the U.S. Naval Academy Board of Visitors

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-09

    ... Department of the Navy Meeting of the U.S. Naval Academy Board of Visitors AGENCY: Department of the Navy, DoD. ACTION: Notice of partially closed meeting. SUMMARY: The U.S. Naval Academy Board of Visitors... Naval Academy. The executive session of this meeting from 11 a.m. to 12 p.m. on December 6, 2010,...

  7. Academies: It's Time to Learn the Lessons. NFER Thinks: What the Evidence Tells Us

    ERIC Educational Resources Information Center

    Worth, Jack

    2015-01-01

    Academies are now a part of the English school landscape. Future policy should focus on learning the lessons from the growth of academy schools. In this "NFER Thinks," the author presents the case that any future expansion in the number of academies should be motivated by a clear vision of the long-term outcomes for learners that…

  8. 78 FR 65977 - Board of Visitors, United States Military Academy (USMA)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-04

    ... Department of the Army Board of Visitors, United States Military Academy (USMA) AGENCY: Department of the... advisory committee meeting will not take place: 1. Name of Committee: United States Military Academy Board... of appropriations, the Department of Defense cancelled the meeting of the U.S. Military Academy...

  9. 77 FR 58529 - Board of Visitors, United States Military Academy (USMA)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-21

    ... Department of the Army Board of Visitors, United States Military Academy (USMA) AGENCY: Department of the... advisory committee meeting will take place: 1. Name of Committee: United States Military Academy Board of... statements should be sent to the Designated Federal Officer (DFO) at: United States Military Academy,...

  10. 76 FR 60816 - Board of Visitors, United States Military Academy (USMA)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-30

    ... Department of the Army Board of Visitors, United States Military Academy (USMA) AGENCY: Department of the... advisory committee meeting will take place: 1. Name of Committee: United States Military Academy Board of... statements should be sent to the Designated Federal Officer (DFO) at: United States Military Academy,...

  11. 76 FR 41490 - Board of Visitors, United States Military Academy (USMA)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-14

    ... Department of the Army Board of Visitors, United States Military Academy (USMA) AGENCY: Department of the... advisory committee meeting will take place: 1. Name of Committee: United States Military Academy Board of... States Military Academy, Office of the Secretary of the General Staff (MASG), 646 Swift Road, West...

  12. 76 FR 31308 - Board of Visitors, United States Military Academy (USMA)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-31

    ... Department of the Army Board of Visitors, United States Military Academy (USMA) AGENCY: Department of the... advisory committee meeting will take place: 1. Name of Committee: United States Military Academy Board of.... Agenda: The Academy leadership will provide the Board updates on the following: Military...

  13. 75 FR 7571 - Board of Visitors, United States Military Academy (USMA)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-22

    ... Department of the Army Board of Visitors, United States Military Academy (USMA) AGENCY: Department of the... Committee: United States Military Academy Board of Visitors. 2. Date: Tuesday, March 9, 2010. 3. Time: 12:30... Designated Federal Officer (DFO) at: United States Military ] Academy, Office of the Secretary of the...

  14. 76 FR 5143 - Board of Visitors, United States Military Academy (USMA)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-28

    ... Department of the Army Board of Visitors, United States Military Academy (USMA) AGENCY: Department of the... States Military Academy Board of Visitors. This is the 2011 Organizational Meeting of the USMA Board of... States Military Academy Board of Visitors. 2. Date: Wednesday, February 16, 2011. ] 3. Time: 12...

  15. Use of Biographical and Interview Information in Predicting Naval Academy Disenrollment.

    ERIC Educational Resources Information Center

    Dann, Joyce E.; Abrahams, Norman M.

    Given the attrition rate of nearly 30 percent for each entering U.S. Naval Academy class an attrition prediction instrument for use in selection could represent considerable monetary savings. In previous research, the Naval Academy Personal History Booklet (PHB) has shown some validity as a predictor of Academy disenrollment. The present research…

  16. 78 FR 13030 - Board of Visitors, United States Military Academy (USMA)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-26

    ... Department of the Army Board of Visitors, United States Military Academy (USMA) AGENCY: Department of the... advisory committee meeting will take place: 1. Name of Committee: United States Military Academy Board of... (DFO) at: United States Military Academy, Office of the Secretary of the General Staff (MASG),...

  17. Graphic Arts: Book Three. The Press and Related Processes.

    ERIC Educational Resources Information Center

    Farajollahi, Karim; And Others

    The third of a three-volume set of instructional materials for a graphic arts course, this manual consists of nine instructional units dealing with presses and related processes. Covered in the units are basic press fundamentals, offset press systems, offset press operating procedures, offset inks and dampening chemistry, preventive maintenance…

  18. Along Freedom's Double Edge: The Arab Press Under Israeli Occupation.

    ERIC Educational Resources Information Center

    Nasser, Munir K.

    This paper examines the Arab press under Israeli occupation and presents two hypotheses: freedom of the press under occupation serves both Israeli interests and the Arab population, and freedom of the Arab press under occupation is "relative" and "controlled." By allowing freedom of expression, the Israelis achieve several aims: a free press will…

  19. Textbook Sales Drop, and University Presses Search for Reasons

    ERIC Educational Resources Information Center

    Howard, Jennifer

    2008-01-01

    This article reports that textbook sales are falling at many university presses, a trend that has accelerated in the past couple of months. That's the word from press directors anxious about the decline but unsure what's causing it or how to stop it. Not every press has been affected. Two of the biggest players, Oxford University Press and…

  20. Roller presses -- Versatile equipment for mineral processing

    SciTech Connect

    Pietsch, W.

    1995-12-31

    Roller presses were first invented in the middle of the 19th century for the economical size enlargement of coal fines as fuels. In addition to contemporary coal briquetting, in fields such as smokeless fuel and form-coke, it was found that redesigned and modernized roller presses, which are now capable of exerting high forces, are versatile machines for many tasks in mineral processing. Today they are used for: the classic pressure agglomeration and the new high pressure comminution. In pressure agglomeration, the characteristics of fine minerals are improved by forming briquettes or granulated products from compacts. During size enlargement with roller presses briquettes are directly obtained while granular materials are produced by crushing and sizing of compacted sheets. A relatively new application of roller presses in mineral processing is the utilization of the crushing effect when brittle materials pass the nip area between the rollers. It was found that this crushing mechanism is very efficient thus saving energy, particularly in grinding circuits handling large capacities. The paper introduces the fundamentals of the process and describes the design as well as applications of modern roller presses in mineral processing.

  1. Lever-press conditioning in the crab.

    PubMed

    Abramson, C I; Feinman, R D

    1990-08-01

    An operant chamber has been developed for studying lever-press conditioning in the green crab Carcinus maenas. In one series of experiments, animals were presented with a single bar and were reinforced with food for every bar press. Performance increased over time and high rates of responding were observed after 2 days of training. The response rate was always higher than that for a yoked (noncontingent) control group. When the contingencies were switched, the animals adjusted to the new conditions. Discrimination in the lever-press apparatus was demonstrated in a second experiment in which crabs had to choose between two bars, one (S+) caused food to be dispensed while the other (S-) was inactive. Experimental animals pressed the S+ bar at a significantly higher rate than the S- bar. When the contingencies associated with the lever were reversed, animals learned to switch to the correct bar by the second day. It was not necessary to reinforce every response: animals maintained high rates of responding on a schedule where every other response was reinforced. Animals used different methods of pressing the bar; the most common was extension of the claw, predominantly at the meropodite-carpopodite joint. PMID:2255730

  2. AUPress: A Comparison of an Open Access University Press with Traditional Presses

    ERIC Educational Resources Information Center

    McGreal, Rory; Chen, Nian-Shing

    2011-01-01

    This study is a comparison of AUPress with three other traditional (non-open access) Canadian university presses. The analysis is based on the rankings that are correlated with book sales on Amazon.com and Amazon.ca. Statistical methods include the sampling of the sales ranking of randomly selected books from each press. The results of one-way…

  3. A precision press-fit instrument for assembling small parts

    NASA Astrophysics Data System (ADS)

    Lou, Zhifeng; Wang, Xiaodong; You, Bo; Xu, Yang

    2015-02-01

    In the paper, a precision press-fit instrument for assembling small interference fitting parts is introduced, which includes pressing module and parts alignment module. The pressing module was used to clamp and position parts, and parts alignment module was used for the two parts' alignment. Through analyzing press-fit control method, component alignment and adjustment strategy, and machine vision device calibration method, the instrument meets the pressing requirements of precision small components. Finite element method is used to predict the reasonable range of press-fit force, and pressing result of the instrument is tested by experiments.

  4. Evaluation of the Efficacy of the H. pylori Protein HP-NAP as a Therapeutic Tool for Treatment of Bladder Cancer in an Orthotopic Murine Model.

    PubMed

    Codolo, Gaia; Munari, Fabio; Fassan, Matteo; de Bernard, Marina

    2015-01-01

    Bladder cancer is one of the most common malignancies of the urogenital tract. Intravesical injection of Bacillus Calmette-Guérin (BCG) is the gold standard treatment for the high-grade non-muscle invasive bladder cancer (NMIBC). However, since the treatment-related side effects are relevant, newer biological response modifiers with a better benefit/side effects ratio are needed. The tumour microenvironment can influence both tumour development and therapy efficacy. In order to obtain a good model, it is desirable to implant tumour cells in the organ from which the cancer originates. In this protocol, we describe a method for establishing a tumour in the bladder cavity of female mice and subsequent delivery of therapeutic agents; the latter are exemplified by our use of Helicobacter pylori neutrophil activating protein (HP-NAP). A preliminary chemical burn of the mucosa, followed by the injection of mouse urothelial carcinoma cell line MB49 via urethral catheterization, enables the cells to attach to the bladder mucosa. After a period, required to allow an initial proliferation of the cells, mice are treated with HP-NAP, administrated again via catheterization. The anti-tumour activity of HP-NAP is evaluated comparing the tumour volume, the extent of necrosis and the degree of vascularization between vehicle- and HP-NAP-treated animals. PMID:26068073

  5. Integrated synthesis of zeolites 4A and Na-P1 using coal fly ash for application in the formulation of detergents and swine wastewater treatment.

    PubMed

    Cardoso, Ariela M; Horn, Martha B; Ferret, Lizete S; Azevedo, Carla M N; Pires, Marçal

    2015-04-28

    Several researchers have reported zeolite synthesis using coal ash for a wide range of applications. However, little attention has been given to green processes, including moderate synthesis conditions, using waste as raw material and effluent reuse or reduction. In this study, Brazilian coal fly ashes were used for integrated synthesis of zeolites 4A and Na-P1 by two different routes and under moderate operating conditions (temperature and pressure). Both procedures produced zeolites with similar conversions (zeolite 4A at 82% purity and zeolite Na-P1 at 57-61%) and high CEC values (zeolites 4A: 4.5meqCa(2+)g(-1) and zeolites Na-P1: 2.6-2.8meqNH4(+)g(-1)). However, process 1 generated less effluent for the zeolite mass produced (7mLg(-1)), with low residual Si and Al levels and 74% of the Si available in the coal fly ash incorporated into the zeolite, while only 55% is used in process 2. For use as a builder in detergents, synthetic zeolite 4A exhibited conformity parameters equal to or greater than those of the commercial zeolite adopted as reference. Treatment of swine wastewater with zeolite Na-P1 resulted in a high removal capacity for total ammoniacal nitrogen (31mgg(-1)). PMID:25621833

  6. [RELATIONS BETWEEN STANISŁAW ESTREICHER AND THE ACADEMY OF ARTS AND SCIENCES AND THE POLISH ACADEMY OF ARTS AND SCIENCES (IN THE LIGHT OF ITS FILES)].

    PubMed

    Skrzyński, Tomasz

    2015-01-01

    Stanisław Estreicher, member of the Estreicher family, which rendered great service to Polish science and culture, was one of the most prominent Polish researchers in the history of law and vice-chancellor of the Jagiellonian University. This future professor for the first time appeared in the files of the Academy already in 1888. In 1914 he was elected associate member and in 1930--full member of the Academy. Because of his diverse interests, Estreicher's activity in the Academy included, i.a., his involvement with the Academy's authorities and the Department of History and Philosophy, his work dealing with general publications of the Academy, publishing his own writings and source editions, activity on the forums of six commissions, representing the Academy and giving opinions on scientific works to be published by the Academy. His involvement in the Academy was growing but these ties did not dominate his diverse activities. From the point of view of the Academy, the most of important was Professor Estreicher's participation in general publications' issues and his increasing influence on the institution's authorities, on the Department of History and Philosophy and the Legal Committee. On the other hand, from the point of view of Professor Estreicher himself, the most significant was "Polish Bibliography". PMID:26455001

  7. Long-Term Single and Joint Effects of Excessive Daytime Napping on the HOMA-IR Index and Glycosylated Hemoglobin: A Prospective Cohort Study.

    PubMed

    Li, Xue; Pang, Xiuyu; Zhang, Qiao; Qu, Qiannuo; Hou, Zhigang; Liu, Zhipeng; Lv, Lin; Na, Guanqiong; Zhang, Wei; Sun, Changhao; Li, Ying

    2016-02-01

    This prospective cohort study was conducted to assess the duration of daytime napping and its effect combined with night sleep deprivation on the risk of developing high HOMA-IR (homeostasis model assessment of insulin resistance) index and disadvantageous changes in glycosylated hemoglobin (HbA1c) levels.A total of 5845 diabetes-free subjects (2736 women and 3109 men), 30 to 65 years of age, were targeted for this cohort study since 2008. Multiple adjusted Cox regression models were performed to evaluate the single and joint effects of daytime napping on the risk of an elevated HbA1c level and high HOMA-IR index.After an average of 4.5 years of follow-up, >30 minutes of daytime napping was significantly associated with an increased risk of an elevated HbA1c level (>6.5%) in men and women (all P trend < 0.05). Hazard ratios (HRs) for an HbA1c level between 5.7% and 6.4% were also significant in the entire cohort and women, but nonsignificant in men. HRs (95% confidence interval, CIs) for the high HOMA-IR index in the entire cohort, men, and women were 1.33 (1.10-1.62), 1.46 (1.08-1.98), and 1.47 (1.12-1.91), respectively. The combination of sleep deprivation with no naps or >30 minutes napping and the combination of no sleep deprivation with >30 minutes daytime napping were all associated with an HbA1c level >6.5% (HR = 2.08, 95% CI = 1.24-3.51; HR = 4.00, 95% CI = 2.03-7.90; and HR = 2.05, 95% CI = 1.29-3.27, respectively). No sleep deprivation combined with >30 minutes daytime napping correlated with a high risk of an HbA1c level between 5.7% and 6.4% and high HOMA-IR index (HR = 2.12, 95% CI = 1.48-3.02; and HR = 1.35, 95% CI = 1.10-1.65, respectively).Daytime napping >30 minutes was associated with a high risk of an elevated HbA1c level and high HOMA-IR index. No sleep deprivation combined with napping >30 minutes carries a risk of abnormal glucose metabolism. Sleep deprivation combined with brief daytime napping <30

  8. Management academy for public health: creating entrepreneurial managers.

    PubMed

    Orton, Stephen; Umble, Karl; Zelt, Sue; Porter, Janet; Johnson, Jim

    2007-04-01

    The Management Academy for Public Health develops public health managers' management skills. Ultimately, the program aims to develop civic entrepreneurs who can improve the efficiency and the effectiveness of their organizations. With help from a coach, teams write public health business plans to meet needs in their communities. An external evaluation found that 119 teams trained during the first 3 years of the program generated more than $6 million in enhanced revenue-including grants, contracts, and fees through their business plans--from $2 million in program funding. Approximately 38% of the teams expected to generate revenue from an academy business plan or a spin-off plan. Action-learning methods can help midcareer managers transfer their training to the workplace and build entrepreneurial skills. PMID:17329658

  9. Simulator investigations of side-stick controller/stability and control augmentation systems for night nap-of-earth flight

    NASA Technical Reports Server (NTRS)

    Landis, K. H.; Aiken, E. W.

    1984-01-01

    Several night nap-of-the-earth mission tasks were evaluated using a helmet-mounted display which provided a limited field-of-view image with superimposed flight control symbology. A wide range of stability and control augmentation designs was investigated. Variations in controller force-deflection characteristics and the number of axes controlled through an integrated side-stick controller were studied. In general, a small displacement controller is preferred over a stiffstick controller particularly for maneuvering flight. Higher levels of stability augmentation were required for IMC tasks to provide handling qualities comparable to those achieved for the same tasks conducted under simulated visual flight conditions. Previously announced in STAR as N82-23216

  10. Study of resonant scattering of 21Na+p relevant to astrophysical 18Ne(α,p)21Na reaction

    NASA Astrophysics Data System (ADS)

    He, J. J.; Zhang, L. Y.; Xu, S. W.; Chen, S. Z.; Hu, J.; Ma, P.; Chen, R. F.; Yamaguchi, H.; Kubono, S.; Hashimoto, T.; Kahl, D.; Hayakawa, S.; Wakabayashi, Y.; Togano, Y.; Wang, H. W.; Tian, W. D.; Guo, B.; Teranishi, T.; Iwasa, N.; Yamada, T.; Komatsubara, T.

    2012-11-01

    Astrophysical 18Ne(α,p)21Na reaction is one of the most probable breakout routes, which lead to the rp-process from the hot-CNO cycle, converting the initial CNO elements into heavier elements in Type I x-ray bursters. Presently, there is no much experimental cross-section data reported at the energy of astrophysical interest, and resonant spectroscopic information in compound 22Mg is scarce as well. The experiment has been carried out by using the CNS radioactive ion beam separator (CRIB). Resonant properties in 22Mg have been studied via the resonant elastic scattering of 21Na+p, and cross section of the time-reversal reaction of 21Na(p,α)18Ne been measured simultaneously. A wide excitation energy region up to Ex ~ 9.5 MeV in 22Mg has been scanned with a thick-target method. Some preliminary results will be reported.

  11. Financial Operations of the Five Service Academies: Department of Defense, Department of Transportation, Department of Commerce. Report to the Congress by the Comptroller General of the United States.

    ERIC Educational Resources Information Center

    Comptroller General of the U.S., Washington, DC.

    This is the first report of the review of operations of five service academies operated by the government: U.S. Military Academy, West Point, New York; Naval Academy, Annapolis, Maryland; Air Force Academy, Colorado Springs, Colorado; Coast Guard Academy, New London, Connecticut; and Merchant Marine Academy, Kings Point, New York. This report…

  12. Improvement of touch sensitivity by pressing.

    PubMed

    Jeong, Hie-yong; Higashimori, Mitsuru; Kaneko, Makoto

    2008-01-01

    It is really interesting to know how a blood flow has an influence on a touch sensitivity during human fingertip exploration over an environment. In this paper, we examine experimentally how the touch sensitivity is changed under the condition that the blood flow is interrupted compulsorily by pressing the proximal phalange of human finger. Through the weight discrimination test based on Weber's Law, we found that the touch sensitivity improves temporarily with the statistical significance test of below 0.1 %, when a finger proximal phalange is bound and pressed. Experimental results also show that there exists a meaningful correlationship between the stiffness of fingertip and the touch sensitivity. PMID:19163188

  13. STS-121: Discovery Post Launch Press Briefing

    NASA Technical Reports Server (NTRS)

    2006-01-01

    The briefing begins with Dean Acousta (NASA Press Secretary) introducing Michael Griffin (NASA Administrator), Bill Gerstenmaier (Associate Administrator for Space Operations) Wayne Hale (Space Shuttle Program Manager), John Shannon (Chairman, Mission Management Team, JSC), and Mike Leinbach (NASA Launch Director). The teams effort and dedication paid off in the form of a perfect launch and the weather cooperated. The Mission Management Team no problems during inspection. Debris assessment at 2 min. 47 sec. and 4 min. 50 sec. will be discussed when that information becomes available.The floor was then open for questions from the press.

  14. Aerial view of the Press Site

    NASA Technical Reports Server (NTRS)

    1998-01-01

    In this aerial view, The News Center sits beyond a large parking lot, on a hill at the northeastern end of the Launch Complex 39 Area , next to the turn basin (at left). From left, the grandstand faces the launch pads several miles away on the Atlantic seashore; behind it, the television studio is the site of media conferences; next, the large white-roofed building is the hub of information and activity for press representatives. Lined up on the right of the Press Site are various buildings and trailers, home to major news networks. The parking lot can accommodate the hundreds of media personnel who attend Space Shuttle launches.

  15. In Brief: Science academies' statement on climate change

    NASA Astrophysics Data System (ADS)

    Showstack, Randy

    2009-06-01

    “It is essential that world leaders agree on emissions reductions needed to combat negative consequences of anthropogenic climate change,” national science academies from 13 countries declared in a joint statement issued on 11 June. The statement, issued by the academies of the G8 countries—including England, France, Russia, and the United States—and five other countries (Brazil, China, India, Mexico, and South Africa), came in advance of a G8 meeting in Italy in July and prior to United Nations Framework Convention on Climate Change (UNFCCC) negotiations in Denmark in December. “The G8+5 should lead the transition to an energy-efficient and low-carbon world economy, and foster innovation and research and development for both mitigation and adaptation technologies,” the statement noted. The academies urged governments to agree at the UNFCCC negotiations to adopt a long-term global goal and short-term emissions reduction targets so that by 2050 global emissions would be reduced by about 50% from 1990 levels.

  16. Napping on the Night Shift: A Study of Sleep, Performance, and Learning in Physicians-in-Training

    PubMed Central

    McDonald, Jennifer; Potyk, Darryl; Fischer, David; Parmenter, Brett; Lillis, Teresa; Tompkins, Lindsey; Bowen, Angela; Grant, Devon; Lamp, Amanda; Belenky, Gregory

    2013-01-01

    Background Physicians in training experience fatigue from sleep loss, high workload, and working at an adverse phase of the circadian rhythm, which collectively degrades task performance and the ability to learn and remember. To minimize fatigue and sustain performance, learning, and memory, humans generally need 7 to 8 hours of sleep in every 24-hour period. Methods In a naturalistic, within-subjects design, we studied 17 first- and second-year internal medicine residents working in a tertiary care medical center, rotating between day shift and night float every 4 weeks. We studied each resident for 2 weeks while he/she worked the day shift and for 2 weeks while he/she worked the night float, objectively measuring sleep by wrist actigraphy, vigilance by the Psychomotor Vigilance Task test, and visual-spatial and verbal learning and memory by the Brief Visuospatial Memory Test-Revised and the Rey Auditory-Verbal Learning Test. Results Residents, whether working day shift or night float, slept approximately 7 hours in every 24-hour period. Residents, when working day shift, consolidated their sleep into 1 main sleep period at night. Residents working night float split their sleep, supplementing their truncated daytime sleep with nighttime on-duty naps. There was no difference in vigilance or learning and memory, whether residents worked day shift or night float. Conclusions Off-duty sleep supplemented with naps while on duty appears to be an effective strategy for sustaining vigilance, learning, and memory when working night float. PMID:24455014

  17. Multicenter Approach to Recurrent Acute and Chronic Pancreatitis in the United States: The North American Pancreatitis Study 2 (NAPS2)

    PubMed Central

    Whitcomb, David C.; Yadav, Dhiraj; Adam, Slivka; Hawes, Robert H.; Brand, Randall E.; Anderson, Michelle A.; Money, Mary E.; Banks, Peter A.; Bishop, Michele D.; Baillie, John; Sherman, Stuart; DiSario, James; Burton, Frank R.; Gardner, Timothy B.; Amann, Stephen T.; Gelrud, Andres; Lo, Simon K.; DeMeo, Mark T.; Steinberg, William M.; Kochman, Michael L.; Etemad, Babak; Forsmark, Christopher E.; Elinoff, Beth; Greer, Julia B.; O’Connell, Michael; Lamb, Janette; Barmada, M. Michael

    2008-01-01

    Background Recurrent acute pancreatitis (RAP) and chronic pancreatitis (CP) are complex syndromes associated with numerous etiologies, clinical variables and complications. We developed the North American Pancreatitis Study 2 (NAPS2) to be sufficiently powered to understand the complex environmental, metabolic and genetic mechanisms underlying RAP and CP. Methods Between August 2000 and September 2006, a consortium of 20 expert academic and private sites prospectively ascertained 1,000 human subjects with RAP or CP, plus 695 controls (spouse, family, friend or unrelated). Standardized questionnaires were completed by both the physicians and study subjects and blood was drawn for genomic DNA and biomarker studies. All data were double-entered into a database and systematically reviewed to minimize errors and include missing data. Results A total of 1,000 subjects (460 RAP, 540 CP) and 695 controls who completed consent forms and questionnaires and donated blood samples comprised the final dataset. Data were organized according to diagnosis, supporting documentation, etiological classification, clinical signs and symptoms (including pain patterns and duration, and quality of life), past medical history, family history, environmental exposures (including alcohol and tobacco use), medication use and therapeutic interventions. Upon achieving the target enrollment, data were organized and classified to facilitate future analysis. The approaches, rationale and datasets are described, along with final demographic results. Conclusion The NAPS2 consortium has successfully completed a prospective ascertainment of 1,000 subjects with RAP and CP from the USA. These data will be useful in elucidating the environmental, metabolic and genetic conditions, and to investigate the complex interactions that underlie RAP and CP. PMID:18765957

  18. 7 CFR 58.421 - Press.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Press. 58.421 Section 58.421 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) REGULATIONS AND STANDARDS UNDER THE AGRICULTURAL MARKETING ACT OF 1946 AND THE...

  19. Does Science Get the Press It Deserves?

    ERIC Educational Resources Information Center

    Wilkie, Tom

    1991-01-01

    Discusses concerns about public understanding of science in the United Kingdom in relation to structure and content of newspapers, particularly the inadequacy of the press to be a vehicle for promoting scientific literacy within the citizenry. Argues that changes in science coverage by the media must originate from the scientific community with…

  20. When International Press Rights "Are" the News

    ERIC Educational Resources Information Center

    Freedman, Eric

    2006-01-01

    In many countries, reporters and editors face criminal prosecution, censorship, self-censorship, exile, tax audits, loss of broadcast and publication licenses, loss of jobs, assault, and even assassination based on how they practice their profession. Press rights and human rights advocacy groups try to draw media and official attention to those…