Science.gov

Sample records for accelerated aging experiments

  1. Accelerated Aging Experiments for Capacitor Health Monitoring and Prognostics

    NASA Technical Reports Server (NTRS)

    Kulkarni, Chetan S.; Celaya, Jose Ramon; Biswas, Gautam; Goebel, Kai

    2012-01-01

    This paper discusses experimental setups for health monitoring and prognostics of electrolytic capacitors under nominal operation and accelerated aging conditions. Electrolytic capacitors have higher failure rates than other components in electronic systems like power drives, power converters etc. Our current work focuses on developing first-principles-based degradation models for electrolytic capacitors under varying electrical and thermal stress conditions. Prognostics and health management for electronic systems aims to predict the onset of faults, study causes for system degradation, and accurately compute remaining useful life. Accelerated life test methods are often used in prognostics research as a way to model multiple causes and assess the effects of the degradation process through time. It also allows for the identification and study of different failure mechanisms and their relationships under different operating conditions. Experiments are designed for aging of the capacitors such that the degradation pattern induced by the aging can be monitored and analyzed. Experimental setups and data collection methods are presented to demonstrate this approach.

  2. Menopause accelerates biological aging.

    PubMed

    Levine, Morgan E; Lu, Ake T; Chen, Brian H; Hernandez, Dena G; Singleton, Andrew B; Ferrucci, Luigi; Bandinelli, Stefania; Salfati, Elias; Manson, JoAnn E; Quach, Austin; Kusters, Cynthia D J; Kuh, Diana; Wong, Andrew; Teschendorff, Andrew E; Widschwendter, Martin; Ritz, Beate R; Absher, Devin; Assimes, Themistocles L; Horvath, Steve

    2016-08-16

    Although epigenetic processes have been linked to aging and disease in other systems, it is not yet known whether they relate to reproductive aging. Recently, we developed a highly accurate epigenetic biomarker of age (known as the "epigenetic clock"), which is based on DNA methylation levels. Here we carry out an epigenetic clock analysis of blood, saliva, and buccal epithelium using data from four large studies: the Women's Health Initiative (n = 1,864); Invecchiare nel Chianti (n = 200); Parkinson's disease, Environment, and Genes (n = 256); and the United Kingdom Medical Research Council National Survey of Health and Development (n = 790). We find that increased epigenetic age acceleration in blood is significantly associated with earlier menopause (P = 0.00091), bilateral oophorectomy (P = 0.0018), and a longer time since menopause (P = 0.017). Conversely, epigenetic age acceleration in buccal epithelium and saliva do not relate to age at menopause; however, a higher epigenetic age in saliva is exhibited in women who undergo bilateral oophorectomy (P = 0.0079), while a lower epigenetic age in buccal epithelium was found for women who underwent menopausal hormone therapy (P = 0.00078). Using genetic data, we find evidence of coheritability between age at menopause and epigenetic age acceleration in blood. Using Mendelian randomization analysis, we find that two SNPs that are highly associated with age at menopause exhibit a significant association with epigenetic age acceleration. Overall, our Mendelian randomization approach and other lines of evidence suggest that menopause accelerates epigenetic aging of blood, but mechanistic studies will be needed to dissect cause-and-effect relationships further. PMID:27457926

  3. Accelerated Aging Experiments for Prognostics of Damage Growth in Composite Materials

    NASA Technical Reports Server (NTRS)

    Saxena, Abhinav; Goebel, Kai Frank; Larrosa, Cecilia C.; Janapati, Vishnuvardhan; Roy, Surajit; Chang, Fu-Kuo

    2011-01-01

    Composite structures are gaining importance for use in the aerospace industry. Compared to metallic structures their behavior is less well understood. This lack of understanding may pose constraints on their use. One possible way to deal with some of the risks associated with potential failure is to perform in-situ monitoring to detect precursors of failures. Prognostic algorithms can be used to predict impending failures. They require large amounts of training data to build and tune damage model for making useful predictions. One of the key aspects is to get confirmatory feedback from data as damage progresses. These kinds of data are rarely available from actual systems. The next possible resource to collect such data is an accelerated aging platform. To that end this paper describes a fatigue cycling experiment with the goal to stress carbon-carbon composite coupons with various layups. Piezoelectric disc sensors were used to periodically interrogate the system. Analysis showed distinct differences in the signatures of growing failures between data collected at conditions. Periodic X-radiographs were taken to assess the damage ground truth. Results after signal processing showed clear trends of damage growth that were correlated to damage assessed from the X-ray images.

  4. Wake field acceleration experiments

    SciTech Connect

    Simpson, J.D.

    1988-01-01

    Where and how will wake field acceleration devices find use for other than, possibly, accelerators for high energy physics. I don't know that this can be responsibly answered at this time. What I can do is describe some recent results from an ongoing experimental program at Argonne which support the idea that wake field techniques and devices are potentially important for future accelerators. Perhaps this will spawn expanded interest and even new ideas for the use of this new technology. The Argonne program, and in particular the Advanced Accelerator Test Facility (AATF), has been reported in several fairly recent papers and reports. But because this is a substantially new audience for the subject, I will include a brief review of the program and the facility before describing experiments. 10 refs., 7 figs.

  5. PETN Coarsening - Predictions from Accelerated Aging Data

    SciTech Connect

    Maiti, Amitesh; Gee, Richard H.

    2011-03-30

    Ensuring good ignition properties over long periods of time necessitates maintaining a good level of porosity in powders of initiator materials and preventing particle coarsening. To simulate porosity changes of such powder materials over long periods of time a common strategy is to perform accelerated aging experiments over shorter time spans at elevated temperatures. In this paper we examine historical accelerated-aging data on powders of Pentaerythritol Tetranitrate (PETN), an important energetic material, and make predictions for long-term aging under ambient conditions. Lastly, we develop an evaporation-condensation- based model to provide some mechanistic understanding of the coarsening process.

  6. Non-accelerator experiments

    SciTech Connect

    Goldhaber, M.

    1986-01-01

    This report discusses several topics which can be investigated without the use of accelerators. Topics covered are: (1) proton decay, (2) atmospheric neutrinos, (3) neutrino detection, (4) muons from Cygnus X-3, and (5) the double-beta decay.

  7. Accelerated aging test on LEDs life estimation

    NASA Astrophysics Data System (ADS)

    Dong, Yi; Zhang, Shu-sheng; Du, Jiang-qi

    2011-11-01

    Light-emitting diodes(LEDs) have become very attractive in different application field such as Solid State Lighting, automotive and street lights, due to their long operative lifetime, lower energy consumption etc. This paper mainly introduces the accelerated aging test, we focus our attention on the study of a life model for LEDs by relating the time to failure with the supplying condition. The constant accelerated aging experiments were firstly performed on LED samples. Process the experiment data by exploiting the degradation of LED optical power formula and degradation coefficient. Finally, the average lifetime of the samples under normal conditions was calculated via using numerical analytical method. According to data, analysis the test result and the failure mechanism of LED, provide the technical basis to improve product design and quality assurance.

  8. The Orbital Acceleration Research Experiment

    NASA Astrophysics Data System (ADS)

    Blanchard, R. C.; Hendrix, M. K.; Fox, J. C.; Thomas, D. J.; Nicholson, J.

    The hardware and software of NASA's proposed Orbital Acceleration Research Experiment (OARE) are described. The OARE is to provide aerodynamic acceleration measurements along the Orbiter's principal axis in the free-molecular flow-flight regime at orbital attitude and in the transition regime during reentry. Models considering the effects of electromagnetic effects, solar radiation pressure, orbiter mass attraction, gravity gradient, orbital centripetal acceleration, out-of-orbital-plane effects, orbiter angular velocity, structural noise, mass expulsion signal sources, crew motion, and bias on acceleration are examined. The experiment contains an electrostatically balanced cylindrical proofmass accelerometer sensor with three orthogonal sensing axis outputs. The components and functions of the experimental calibration system and signal processor and control subsystem are analyzed. The development of the OARE software is discussed. The experimental equipment will be enclosed in a cover assembly that will be mounted in the Orbiter close to the center of gravity.

  9. The Orbital Acceleration Research Experiment

    NASA Technical Reports Server (NTRS)

    Blanchard, R. C.; Hendrix, M. K.; Fox, J. C.; Thomas, D. J.; Nicholson, J.

    1986-01-01

    The hardware and software of NASA's proposed Orbital Acceleration Research Experiment (OARE) are described. The OARE is to provide aerodynamic acceleration measurements along the Orbiter's principal axis in the free-molecular flow-flight regime at orbital attitude and in the transition regime during reentry. Models considering the effects of electromagnetic effects, solar radiation pressure, orbiter mass attraction, gravity gradient, orbital centripetal acceleration, out-of-orbital-plane effects, orbiter angular velocity, structural noise, mass expulsion signal sources, crew motion, and bias on acceleration are examined. The experiment contains an electrostatically balanced cylindrical proofmass accelerometer sensor with three orthogonal sensing axis outputs. The components and functions of the experimental calibration system and signal processor and control subsystem are analyzed. The development of the OARE software is discussed. The experimental equipment will be enclosed in a cover assembly that will be mounted in the Orbiter close to the center of gravity.

  10. Space experiments with particle accelerators

    SciTech Connect

    Obayashi, T.

    1981-11-01

    The purpose of space experiments with particle accelerators (SEPAC) is to carry out active and interactive experiments on and in the Earth's ionosphere and magnetosphere. It is also intended to make an initial performance test for an overall program of Spacelab/SEPAC experiments. The instruments to be used are an electron beam accelerator, magnetoplasma dynamic arcjet, and associated diagnostic equipment. The accelerators are installed on the pallet, with monitoring and diagnostic observations being made by the gas plume release, beam-monitor TV, and particle-wave measuring instruments also mounted on the pallet. Command and display systems are installed in the module. Three major classes of investigations to be performed are vehicle charge neutralization, beam plasma physics, and beam atmosphere interactions. The first two are mainly onboard plasma physics experiments to measure the effect of phenomena in the vicinity of Spacelab. The last one is concerned with atmospheric modification and is supported by other Spacelab 1 investigations as well as by ground-based, remote sensing observations.

  11. Accelerated Aging in Electrolytic Capacitors for Prognostics

    NASA Technical Reports Server (NTRS)

    Celaya, Jose R.; Kulkarni, Chetan; Saha, Sankalita; Biswas, Gautam; Goebel, Kai Frank

    2012-01-01

    The focus of this work is the analysis of different degradation phenomena based on thermal overstress and electrical overstress accelerated aging systems and the use of accelerated aging techniques for prognostics algorithm development. Results on thermal overstress and electrical overstress experiments are presented. In addition, preliminary results toward the development of physics-based degradation models are presented focusing on the electrolyte evaporation failure mechanism. An empirical degradation model based on percentage capacitance loss under electrical overstress is presented and used in: (i) a Bayesian-based implementation of model-based prognostics using a discrete Kalman filter for health state estimation, and (ii) a dynamic system representation of the degradation model for forecasting and remaining useful life (RUL) estimation. A leave-one-out validation methodology is used to assess the validity of the methodology under the small sample size constrain. The results observed on the RUL estimation are consistent through the validation tests comparing relative accuracy and prediction error. It has been observed that the inaccuracy of the model to represent the change in degradation behavior observed at the end of the test data is consistent throughout the validation tests, indicating the need of a more detailed degradation model or the use of an algorithm that could estimate model parameters on-line. Based on the observed degradation process under different stress intensity with rest periods, the need for more sophisticated degradation models is further supported. The current degradation model does not represent the capacitance recovery over rest periods following an accelerated aging stress period.

  12. Cytomegalovirus infection accelerates epigenetic aging.

    PubMed

    Kananen, Laura; Nevalainen, Tapio; Jylhävä, Juulia; Marttila, Saara; Hervonen, Antti; Jylhä, Marja; Hurme, Mikko

    2015-12-01

    Epigenetic mechanisms such as DNA methylation (DNAm) have a central role in the regulation of gene expression and thereby in cellular differentiation and tissue homeostasis. It has recently been shown that aging is associated with profound changes in DNAm. Several of these methylation changes take place in a clock-like fashion, i.e. correlating with the calendar age of an individual. Thus, the epigenetic clock based on these kind of DNAm changes could provide a new biomarker for human aging process, i.e. being able to separate the calendar and biological age. Information about the correlation of the time indicated by this clock to the various aspects of immunosenescence is still missing. As chronic cytomegalovirus (CMV) infection is probably one of the major driving forces of immunosenescence, we now have analyzed the correlation of CMV seropositivity with the epigenetic age in the Vitality 90+cohort 1920 (122 nonagenarians and 21 young controls, CMV seropositivity rates 95% and 57%, respectively). The data showed that CMV seropositivity was associated with a higher epigenetic age in both of these age groups (median 26.5 vs. 24.0 (p < 0.02,Mann–Whitney U-test) in the young controls and 76.0 vs. 70.0 (p < 0.01) in the nonagenarians). Thus, these data provide a new aspect to the CMV associated pathological processes. PMID:26485162

  13. Deuterium accelerator experiments for APT.

    SciTech Connect

    Causey, Rion A. (Sandia National Laboratories, Livermore, CA); Hertz, Kristin L. (Sandia National Laboratories, Livermore, CA); Cowgill, Donald F. (Sandia National Laboratories, Livermore, CA)

    2005-08-01

    Sandia National Laboratories in California initiated an experimental program to determine whether tritium retention in the tube walls and permeation through the tubes into the surrounding coolant water would be a problem for the Accelerator Production of Tritium (APT), and to find ways to mitigate the problem, if it existed. Significant holdup in the tube walls would limit the ability of APT to meet its production goals, and high levels of permeation would require a costly cleanup system for the cooling water. To simulate tritium implantation, a 200 keV accelerator was used to implant deuterium into Al 6061-T and SS3 16L samples at temperatures and particle fluxes appropriate for APT, for times varying between one week and five months. The implanted samples were characterized to determine the deuterium retention and Permeation. During the implantation, the D(d,p)T nuclear reaction was used to monitor the build-up of deuterium in the implant region of the samples. These experiments increased in sophistication, from mono-energetic deuteron implants to multi-energetic deuteron and proton implants, to more accurately reproduce the conditions expected in APT. Micron-thick copper, nickel, and anodized aluminum coatings were applied to the front surface of the samples (inside of the APT walls) in an attempt to lower retention and permeation. The reduction in both retention and permeation produced by the nickel coatings, and the ability to apply them to the inside of the APT tubes, indicate that both nickel-coated Al 6061-T6 and nickel-coated SS3 16L tubes would be effective for use in APT. The results of this work were submitted to the Accelerator Production of Tritium project in document number TPO-E29-Z-TNS-X-00050, APT-MP-01-17.

  14. Accelerated epigenetic aging in Down syndrome

    PubMed Central

    Horvath, Steve; Garagnani, Paolo; Bacalini, Maria Giulia; Pirazzini, Chiara; Salvioli, Stefano; Gentilini, Davide; Di Blasio, Anna Maria; Giuliani, Cristina; Tung, Spencer; Vinters, Harry V; Franceschi, Claudio

    2015-01-01

    Down Syndrome (DS) entails an increased risk of many chronic diseases that are typically associated with older age. The clinical manifestations of accelerated aging suggest that trisomy 21 increases the biological age of tissues, but molecular evidence for this hypothesis has been sparse. Here, we utilize a quantitative molecular marker of aging (known as the epigenetic clock) to demonstrate that trisomy 21 significantly increases the age of blood and brain tissue (on average by 6.6 years, P = 7.0 × 10−14). PMID:25678027

  15. Accelerated epigenetic aging in Down syndrome.

    PubMed

    Horvath, Steve; Garagnani, Paolo; Bacalini, Maria Giulia; Pirazzini, Chiara; Salvioli, Stefano; Gentilini, Davide; Di Blasio, Anna Maria; Giuliani, Cristina; Tung, Spencer; Vinters, Harry V; Franceschi, Claudio

    2015-06-01

    Down Syndrome (DS) entails an increased risk of many chronic diseases that are typically associated with older age. The clinical manifestations of accelerated aging suggest that trisomy 21 increases the biological age of tissues, but molecular evidence for this hypothesis has been sparse. Here, we utilize a quantitative molecular marker of aging (known as the epigenetic clock) to demonstrate that trisomy 21 significantly increases the age of blood and brain tissue (on average by 6.6 years, P = 7.0 × 10(-14)). PMID:25678027

  16. Obesity accelerates epigenetic aging of human liver.

    PubMed

    Horvath, Steve; Erhart, Wiebke; Brosch, Mario; Ammerpohl, Ole; von Schönfels, Witigo; Ahrens, Markus; Heits, Nils; Bell, Jordana T; Tsai, Pei-Chien; Spector, Tim D; Deloukas, Panos; Siebert, Reiner; Sipos, Bence; Becker, Thomas; Röcken, Christoph; Schafmayer, Clemens; Hampe, Jochen

    2014-10-28

    Because of the dearth of biomarkers of aging, it has been difficult to test the hypothesis that obesity increases tissue age. Here we use a novel epigenetic biomarker of aging (referred to as an "epigenetic clock") to study the relationship between high body mass index (BMI) and the DNA methylation ages of human blood, liver, muscle, and adipose tissue. A significant correlation between BMI and epigenetic age acceleration could only be observed for liver (r = 0.42, P = 6.8 × 10(-4) in dataset 1 and r = 0.42, P = 1.2 × 10(-4) in dataset 2). On average, epigenetic age increased by 3.3 y for each 10 BMI units. The detected age acceleration in liver is not associated with the Nonalcoholic Fatty Liver Disease Activity Score or any of its component traits after adjustment for BMI. The 279 genes that are underexpressed in older liver samples are highly enriched (1.2 × 10(-9)) with nuclear mitochondrial genes that play a role in oxidative phosphorylation and electron transport. The epigenetic age acceleration, which is not reversible in the short term after rapid weight loss induced by bariatric surgery, may play a role in liver-related comorbidities of obesity, such as insulin resistance and liver cancer. PMID:25313081

  17. Accelerated Aging with Electrical Overstress and Prognostics for Power MOSFETs

    NASA Technical Reports Server (NTRS)

    Saha, Sankalita; Celaya, Jose Ramon; Vashchenko, Vladislav; Mahiuddin, Shompa; Goebel, Kai F.

    2011-01-01

    Power electronics play an increasingly important role in energy applications as part of their power converter circuits. Understanding the behavior of these devices, especially their failure modes as they age with nominal usage or sudden fault development is critical in ensuring efficiency. In this paper, a prognostics based health management of power MOSFETs undergoing accelerated aging through electrical overstress at the gate area is presented. Details of the accelerated aging methodology, modeling of the degradation process of the device and prognostics algorithm for prediction of the future state of health of the device are presented. Experiments with multiple devices demonstrate the performance of the model and the prognostics algorithm as well as the scope of application. Index Terms Power MOSFET, accelerated aging, prognostics

  18. Experiment specific processing of residual acceleration data

    NASA Technical Reports Server (NTRS)

    Rogers, Melissa J. B.; Alexander, J. I. D.

    1992-01-01

    To date, most Spacelab residual acceleration data collection projects have resulted in data bases that are overwhelming to the investigator of low-gravity experiments. This paper introduces a simple passive accelerometer system to measure low-frequency accelerations. Model responses for experiments using actual acceleration data are produced and correlations are made between experiment response and the accelerometer time history in order to test the idea that recorded acceleration data and experimental responses can be usefully correlated. Spacelab 3 accelerometer data are used as input to a variety of experiment models, and sensitivity limits are obtained for particular experiment classes. The modeling results are being used to create experiment-specific residual acceleration data processing schemes for interested investigators.

  19. Space Experiments with Particle Accelerators (SEPAC)

    NASA Technical Reports Server (NTRS)

    Roberts, W. T.

    1985-01-01

    The space experiments with particle accelerators (SEPAC) instruments consist of an electron accelerator, a plasma accelerator, a neutral gas (N2) release device, particle and field diagnostic instruments, and a low light level television system. These instruments are used to accomplish multiple experiments: to study beam particle interactions and other plasma processes; as probes to investigate magnetospheric processes; and as perturbation devices to study energy coupling mechanisms in the magnetosphere, ionosphere, and upper atmosphere.

  20. Inverse Cerenkov laser acceleration experiment at ATF

    NASA Astrophysics Data System (ADS)

    Wang, X. J.; Pogorelsky, I.; Fernow, R.; Kusche, K. P.; Liu, Y.; Kimura, W. D.; Kim, G. H.; Romea, R. D.; Steinhauer, L. C.

    Inverse Cerenkov laser acceleration was demonstrated using an axicon optical system at the Brookhaven Accelerator Test Facility (ATF). The ATF S-band linac and a high power 10.6 MICROMETERSCO2 laser were used for the experiment. Experimental arrangement and the laser and the electron beams synchronization are discussed. The electrons were accelerated more than 0.7 MeV for a 34 MW CO2 laser power. More than 3.7 MeV acceleration was measured with 0.7 GW CO2 laser power, which is more than 20 times of the previous ICA experiment. The experimental results are compared with computer program TRANSPORT simulations.

  1. Insights into accelerated aging of SSL luminaires

    SciTech Connect

    Davis, J. Lynn; Lamvik, Michael; Bittle, James; Shepherd, Sarah; Yaga, Robert; Baldasaro, Nick; Solano, Eric; Bobashev, Georgiy

    2013-09-30

    Although solid-state lighting (SSL) products are often intended to have product lifetimes of 15 years or more, the rapid change in technology has created a need for accelerated life tests (ALTs) that can be performed in the span of several months. A critical element of interpreting results from any systems-level ALT is understanding of the impact of the test environment on each component. Because of its ubiquity in electronics, the use of temperature-humidity environments as potential ALTs for SSL luminaires was investigated. Results from testing of populations of three commercial 6” downlights in environments of 85oC and 85% relative humidity (RH) and 75oC and 75% RH are reported. These test environments were found to accelerate lumen depreciation of the entire luminaire optical system, including LEDs, lenses, and reflectors. The effects of aging were found to depend strongly on both the optical materials that were used and the design of the luminaire; this shows that the lumen maintenance behavior of SSL luminaires must be addressed at the optical systems level. Temperature-Humidity ALTs can be a useful test in understand lumainaire depreciation provided that proper consideration is given to the different aging rates of various materials. Since the impact of the temperature-humidity environment varies among components of the optical system, uniform aging of all system components in a single test is difficult to achieve.

  2. Insights into accelerated aging of SSL luminaires

    NASA Astrophysics Data System (ADS)

    Davis, J. Lynn; Lamvik, Michael; Bittle, James; Shepherd, Sarah; Yaga, Robert; Baldasaro, Nick; Solano, Eric; Bobashev, Georgiy

    2013-09-01

    Although solid-state lighting (SSL) products are often intended to have product lifetimes of 15 years or more, the rapid change in technology has created a need for accelerated life tests (ALTs) that can be performed in the span of several months. A critical element of interpreting results from any systems-level ALT is understanding of the impact of the test environment on each component. Because of its ubiquity in electronics, the use of temperature-humidity environments as potential ALTs for SSL luminaires was investigated. Results from testing of populations of three commercial 6" downlights in environments of 85°C and 85% relative humidity (RH) and 75°C and 75% RH are reported. These test environments were found to accelerate lumen depreciation of the entire luminaire optical system, including LEDs, lenses, and reflectors. The effects of aging were found to depend strongly on both the optical materials that were used and the design of the luminaire; this shows that the lumen maintenance behavior of SSL luminaires must be addressed at the optical systems level. Temperature-Humidity ALTs can be a useful test in understand lumainaire depreciation provided that proper consideration is given to the different aging rates of various materials. Since the impact of the temperature-humidity environment varies among components of the optical system, uniform aging of all system components in a single test is difficult to achieve.

  3. Insights into accelerated aging of SSL luminaires

    DOE PAGES

    Davis, J. Lynn; Lamvik, Michael; Bittle, James; Shepherd, Sarah; Yaga, Robert; Baldasaro, Nick; Solano, Eric; Bobashev, Georgiy

    2013-09-30

    Although solid-state lighting (SSL) products are often intended to have product lifetimes of 15 years or more, the rapid change in technology has created a need for accelerated life tests (ALTs) that can be performed in the span of several months. A critical element of interpreting results from any systems-level ALT is understanding of the impact of the test environment on each component. Because of its ubiquity in electronics, the use of temperature-humidity environments as potential ALTs for SSL luminaires was investigated. Results from testing of populations of three commercial 6” downlights in environments of 85oC and 85% relative humiditymore » (RH) and 75oC and 75% RH are reported. These test environments were found to accelerate lumen depreciation of the entire luminaire optical system, including LEDs, lenses, and reflectors. The effects of aging were found to depend strongly on both the optical materials that were used and the design of the luminaire; this shows that the lumen maintenance behavior of SSL luminaires must be addressed at the optical systems level. Temperature-Humidity ALTs can be a useful test in understand lumainaire depreciation provided that proper consideration is given to the different aging rates of various materials. Since the impact of the temperature-humidity environment varies among components of the optical system, uniform aging of all system components in a single test is difficult to achieve.« less

  4. Accelerated Aging of Lead-Free Propellant

    NASA Technical Reports Server (NTRS)

    Furrow, Keith W.; Jervey, David D.

    2000-01-01

    Following higher than expected 2-NDPA depletion rates in a lead-free doublebase formulation (RPD-422), an accelerated aging study was conducted to verify the depletion rates. A test plan was prepared to compare the aging characteristics of lead-free propellant and NOSIH-AA2. The study was also designed to determine which lead-free ballistic modifiers accelerated 2-NDPA depletion. The increased depletion rate occurred in propellants containing monobasic copper salicylate. Four lead-free propellants were then formulated to improved aging characteristics over previous lead-free propellant formulations. The new formulations reduced or replaced the monobasic copper salicylate. The new formulations had improved aging characteristics. Their burn rates, however, were unacceptable for use in a 2.75 inch rocket. To compare aging characteristics, stabilizer depletion rates of RPD-422, AA2, M28, and RLC 470/6A were measured or taken from the literature. The data were fit to a kinetic model. The model contained first and zero order terms which allowed the stabilizer concentration to go to zero. In the model, only the concentration of the primary stabilizer was considered. Derivatives beyond the first nitrated or nitroso derivative of 2-NPDA were not considered. The rate constants were fit to the Arrhenius equation and extrapolated to lower temperatures. The time to complete stabilizer depletion was estimated using the kinetic model. The four propellants were compared and the RPD-422 depleted faster at 45 C than both A22 and M28. These types of predictions depend on the validity of the model and on confidence in the Arrhenius relationship holding at lower temperatures. At 45 C, the zero order portion of the model dominates the depletion rate.

  5. Accelerated aging of EPDM and butyl elastomers

    SciTech Connect

    Wilson, M.H.

    1996-06-01

    This study was composed of three parts: a post cure study to optimize final properties of an ethylene-propylene-diene (EPDM) formulation, an accelerated aging study to compare the stress relaxation behavior of a butyl and an EPDM elastomer under compression, and a cursory evaluation of a new 70 Shore A EPDM. The optimum postcure for the EPDM was found to be 2 to 4 hours at 182{degrees}C in a vacuum. The EPDM was also shown to have superior aging characteristics compared to the butyl and is recommended for use instead of the butyl material. The physical properties for new 70 Shore A EPDM are satisfactory, and the stress relaxation behavior was only slightly inferior to the other EPDM.

  6. Degradation mechanisms and accelerated aging test design

    SciTech Connect

    Clough, R L; Gillen, K T

    1985-01-01

    The fundamental mechanisms underlying the chemical degradation of polymers can change as a function of environmental stress level. When this occurs, it greatly complicates any attempt to use accelerated tests for predicting long-term material degradation behaviors. Understanding how degradation mechanisms can change at different stress levels facilitates both the design and the interpretation of aging tests. Oxidative degradation is a predominant mechanism for many polymers exposed to a variety of different environments in the presence of air, and there are two mechanistic considerations which are widely applicable to material oxidation. One involves a physical process, oxygen diffusion, as a rate-limiting step. This mechanism can predominate at high stress levels. The second is a chemical process, the time-dependent decomposition of peroxide species. This leads to chain branching and can become a rate-controlling factor at lower stress levels involving time-scales applicable to use environments. The authors describe methods for identifying the operation of these mechanisms and illustrate the dramatic influence they can have on the degradation behaviors of a number of polymer types. Several commonly used approaches to accelerated aging tests are discussed in light of the behaviors which result from changes in degradation mechanisms. 9 references, 4 figures.

  7. US Particle Accelerators at Age 50.

    ERIC Educational Resources Information Center

    Wilson, R. R.

    1981-01-01

    Reviews the development of accelerators over the past 50 years. Topics include: types of accelerators, including cyclotrons; sociology of accelerators (motivation, financing, construction, and use); impact of war; national laboratories; funding; applications; future projects; foreign projects; and international collaborations. (JN)

  8. Results from non-accelerator experiments

    SciTech Connect

    Wilkerson, J.F.

    1992-01-01

    The diversity of non-accelerator experiments is at first look both dazzling and even daunting. However, nearly all of these experiments strive to attain the same goal, to search for new physics, beyond the current Standard Model. These measurements are also unified in the fact that their results are often dominated by systematic uncertainties. This review necessarily covers only a limited subset of non-accelerator experiments, and will concentrate on the experimental areas where there has been significant recent progress. The topics reviewed include neutrino mazes, double beta decay, solar neutrino, and long-baseline neutrino oscillation measurements.

  9. Accelerator/Experiment Operations - FY 2010

    SciTech Connect

    Adamson, M.; Appel, J.A.; Casarsa, M.; Coleman, R.; Denisov, D.; Dixon, R.; Escobar, C.; Ginther, G.; Gruenendahl, S.; Harris, D.; Henderson, S.; /Fermilab

    2010-11-01

    This Technical Memorandum (TM) summarizes the Fermilab accelerator and accelerator experiment operations for FY 2010. It is one of a series of annual publications intended to gather information in one place. In this case, the information concerns the FY 2010 Run II at the Tevatron Collider, the MINOS and MINER?A experiments using the Main Injector Neutrino Beam (NuMI), the MiniBooNE experiment running in the Booster Neutrino Beam (BNB), and the Meson Test Beam (MTest) activities in the 120 GeV external Switchyard beam (SY120). Each section was prepared by the relevant authors, and was somewhat edited for inclusion in this summary.

  10. Accelerator/Experiment Operations - FY 2011

    SciTech Connect

    Adamson, P.; Bernardi, G.; Casarsa, M.; Coleman, R.; Denisov, D.; Dixon, R.; Ginther, G.; Gruenendahl, S.; Hahn, S.; Harris, D.; Henderson, S.

    2011-11-01

    This Technical Memorandum (TM) summarizes the Fermilab accelerator and accelerator experiment operations for FY 2011. It is one of a series of annual publications intended to gather information in one place. In this case, the information concerns the FY 2011 Run II at the Tevatron Collider, the MINOS and MINERvA experiments using the Main Injector Neutrino Beam (NuMI), the MiniBooNE experiment running in the Booster Neutrino Beam (BNB), and the Meson Test Beam (MTest) activities in the 120 GeV external Switchyard beam (SY120).

  11. Accelerated Application Development: The ORNL Titan Experience

    SciTech Connect

    Joubert, Wayne; Archibald, Richard K.; Berrill, Mark A.; Brown, W. Michael; Eisenbach, Markus; Grout, Ray; Larkin, Jeff; Levesque, John; Messer, Bronson; Norman, Matthew R.; Philip, Bobby; Sankaran, Ramanan; Tharrington, Arnold N.; Turner, John A.

    2015-05-09

    The use of computational accelerators such as NVIDIA GPUs and Intel Xeon Phi processors is now widespread in the high performance computing community, with many applications delivering impressive performance gains. However, programming these systems for high performance, performance portability and software maintainability has been a challenge. In this paper we discuss experiences porting applications to the Titan system. Titan, which began planning in 2009 and was deployed for general use in 2013, was the first multi-petaflop system based on accelerator hardware. To ready applications for accelerated computing, a preparedness effort was undertaken prior to delivery of Titan. In this paper we report experiences and lessons learned from this process and describe how users are currently making use of computational accelerators on Titan.

  12. Accelerated Application Development: The ORNL Titan Experience

    DOE PAGES

    Joubert, Wayne; Archibald, Richard K.; Berrill, Mark A.; Brown, W. Michael; Eisenbach, Markus; Grout, Ray; Larkin, Jeff; Levesque, John; Messer, Bronson; Norman, Matthew R.; et al

    2015-05-09

    The use of computational accelerators such as NVIDIA GPUs and Intel Xeon Phi processors is now widespread in the high performance computing community, with many applications delivering impressive performance gains. However, programming these systems for high performance, performance portability and software maintainability has been a challenge. In this paper we discuss experiences porting applications to the Titan system. Titan, which began planning in 2009 and was deployed for general use in 2013, was the first multi-petaflop system based on accelerator hardware. To ready applications for accelerated computing, a preparedness effort was undertaken prior to delivery of Titan. In this papermore » we report experiences and lessons learned from this process and describe how users are currently making use of computational accelerators on Titan.« less

  13. Inverse Cerenkov laser acceleration experiment at ATF

    SciTech Connect

    Wang, X.J.; Pogorelsky, I.; Fernow, R.; Kusche, K.P.; Liu, Y.; Kimura, W.D.; Kim, G.H.; Romea, R.D.; Steinhauer, L.C.

    1994-09-01

    Inverse Cerenkov laser acceleration was demonstrated using an axicon optical system at the Brookhaven Accelerator Test Facility (ATF). The ATF S-band linac and a high power 10.6 {mu}m CO{sub 2} laser were used for the experiment. Experimental arrangement and the laser and the electron beams synchronization are discussed. The electrons were accelerated more than 0.7 MeV for a 34 MW CO{sub 2} laser power. More than 3.7 MeV acceleration was measured with 0.7 GW CO{sub 2} laser power, which is more than 20 times of the previous ICA experiment. The experimental results are compared with computer program TRANSPORT simulations.

  14. Space experiments with particle accelerators: SEPAC

    NASA Technical Reports Server (NTRS)

    Roberts, B.

    1986-01-01

    The SEPAC instruments consist of an electron accelerator, a plasma accelerator, a neutral gas (N2) release device, particle and field diagnostic instruments, and a low light level television system. These instruments are used to accomplish multiple experiments: to study beam-particle interactions and other plasma processes; as probes to investigate magnetospheric processes; and as perturbation devices to study energy coupling mechanisms in the magnetosphere, ionosphere, and upper atmosphere.

  15. Premature and accelerated aging: HIV or HAART?

    PubMed

    Smith, Reuben L; de Boer, Richard; Brul, Stanley; Budovskaya, Yelena; van Spek, Hans

    2012-01-01

    Highly active antiretroviral therapy (HAART) has significantly increased life expectancy of the human immunodeficiency virus (HIV)-positive population. Nevertheless, the average lifespan of HIV-patients remains shorter compared to uninfected individuals. Immunosenescence, a current explanation for this difference invokes heavily on viral stimulus despite HAART efficiency in viral suppression. We propose here that the premature and accelerated aging of HIV-patients can also be caused by adverse effects of antiretroviral drugs, specifically those that affect the mitochondria. The nucleoside reverse transcriptase inhibitor (NRTI) antiretroviral drug class for instance, is known to cause depletion of mitochondrial DNA via inhibition of the mitochondrial specific DNA polymerase-γ. Besides NRTIs, other antiretroviral drug classes such as protease inhibitors also cause severe mitochondrial damage by increasing oxidative stress and diminishing mitochondrial function. We also discuss important areas for future research and argue in favor of the use of Caenorhabditis elegans as a novel model system for studying these effects.

  16. Accelerated aging of polymer composite bridge materials

    NASA Astrophysics Data System (ADS)

    Carlson, Nancy M.; Blackwood, Larry G.; Torres, Lucinda L.; Rodriguez, Julio G.; Yoder, Timothy S.

    1999-05-01

    Accelerated aging research on samples of composite materials and candidate UV protective coatings is determining the effects of six environmental factors on material durability. Candidate fastener materials are being evaluated to determine corrosion rates and crevice corrosion effects at load-bearing joints. This work supports field testing of a 30-ft long, 18-ft wide polymer matrix composite (PMC) bridge at the Idaho National Engineering and Environmental Laboratory. Durability results and sensor data form test with live loads provide information required for determining the cost/benefit measures to use in life-cycle planning, determining a maintenance strategy, establishing applicable inspection techniques, and establishing guidelines, standards and acceptance criteria for PMC bridges for use in the transportation infrastructure.

  17. Accelerated Aging of Polymer Composite Bridge Materials

    SciTech Connect

    Carlson, Nancy Margaret; Blackwood, Larry Gene; Torres, Lucinda Laine; Rodriguez, Julio Gallardo; Yoder, Timothy Scott

    1999-03-01

    Accelerated aging research on samples of composite material and candidate ultraviolet (UV) protective coatings is determining the effects of six environmental factors on material durability. Candidate fastener materials are being evaluated to determine corrosion rates and crevice corrosion effects at load-bearing joints. This work supports field testing of a 30-ft long, 18-ft wide polymer matrix composite (PMC) bridge at the Idaho National Engineering and Environmental Laboratory (INEEL). Durability results and sensor data from tests with live loads provide information required for determining the cost/benefit measures to use in life-cycle planning, determining a maintenance strategy, establishing applicable inspection techniques, and establishing guidelines, standards, and acceptance criteria for PMC bridges for use in the transportation infrastructure.

  18. The FRC Acceleration Space Thruster (FAST) Experiment

    NASA Technical Reports Server (NTRS)

    Martin, Adam; Eskridge, Richard; Houts, Mike; Slough, John; Rodgers, Stephen L. (Technical Monitor)

    2002-01-01

    The objective of the FRC (Field Reversed Configuration) Acceleration Space Thruster (FAST) Experiment is to investigate the use of a repetitive FRC source as a thruster, specifically for an NEP (nuclear electric propulsion) system. The Field Reversed Configuration is a plasmoid with a closed poloidal field line structure, and has been extensively studied as a fusion reactor core. An FRC thruster works by repetitively producing FRCs and accelerating them to high velocity. An FRC thruster should be capable of I(sub sp)'s in the range of 5,000 - 25,000 seconds and efficiencies in the range of 60 - 80 %. In addition, they can have thrust densities as high as 10(exp 6) N/m2, and as they are inductively formed, they do not suffer from electrode erosion. The jet-power should be scalable from the low to the high power regime. The FAST experiment consists of a theta-pinch formation chamber, followed by an acceleration stage. Initially, we will produce and accelerate single FRCs. The initial focus of the experiment will be on the ionization, formation and acceleration of a single plasmoid, so as to determine the likely efficiency and I(sub sp). Subsequently, we will modify the device for repetitive burst-mode operation (5-10 shots). A variety of diagnostics are or will be available for this work, including a HeNe interferometer, high-speed cameras, and a Thomson-scattering system. The status of the experiment will be described.

  19. Accelerator/Experiment Operations - FY 2008

    SciTech Connect

    Brice, Stephen J.; Buehler, M.; Casarsa, M.; Coleman, R.; Denisov, D.; Ginther, G.; Grinstein, S.; Habig, A.; Holmes, S.; Hylen, J.; Kissel, W.; /Fermilab

    2008-10-01

    This Technical Memorandum (TM) summarizes the Fermilab accelerator and accelerator experiment operations for FY 2008. It is one of a series of annual publications intended to gather information in one place. In this case, the information concerns the FY 2008 Run II at the Tevatron Collider, MINOS using the Main Injector Neutrino Beam (NuMI), the MiniBooNE and SciBooNE experiments running in the Booster Neutrino Beam (BNB), and the Meson Test Beam (MTest) activities in the 120 GeV external Switchyard beam (SY120).

  20. Accelerator/Experiment Operations - FY 2009

    SciTech Connect

    Andrews, M.N; Appel, J.A.; Brice, S.; Casarsa, M.; Coleman, R.; Denisov, d.; Ginther, G.; Gruenendahl, S.; Holmes, S.; Kissel, W.; Lee, W.M.; /Fermilab

    2009-10-01

    This Technical Memorandum (TM) summarizes the Fermilab accelerator and accelerator experiment operations for FY 2009. It is one of a series of annual publications intended to gather information in one place. In this case, the information concerns the FY 2009 Run II at the Tevatron Collider, MINOS using the Main Injector Neutrino Beam (NuMI), the MiniBooNE experiment running in the Booster Neutrino Beam (BNB), and the Meson Test Beam (MTest) activities in the 120 GeV external Switchyard beam (SY120). Each section was prepared by the relevant authors, and was somewhat edited for inclusion in this summary.

  1. Accelerator/Experiment Operations - FY 2007

    SciTech Connect

    Brice, S.; Buchanan, N.; Coleman, R.; Convery, M.; Denisov, D.; Ginther, G.; Habig, A.; Holmes, S.; Kissel, W.; Lee, W.; Nakaya, T.; /Fermilab

    2007-10-01

    This Technical Memorandum (TM) summarizes the Fermilab accelerator and accelerator experiment operations for FY 2007. It is one of a series of annual publications intended to gather information in one place. In this case, the information concerns the FY 2007 Run II at the Tevatron Collider, the MiniBooNE and SciBooNE experiments running in the Booster Neutrino Beam (BNB), MINOS using the Main Injector Neutrino Beam (NuMI), and the Meson Test Beam (MTest) activities in the 120 GeV external Switchyard beam (SY120). Each section was prepared by the relevant authors, and was somewhat edited for inclusion in this summary.

  2. Accelerated aging syndromes, are they relevant to normal human aging?

    PubMed

    Dreesen, Oliver; Stewart, Colin L

    2011-09-01

    Hutchinson-Gilford Progeria (HGPS) and Werner syndromes are diseases that clinically resemble some aspects of accelerated aging. HGPS is caused by mutations in theLMNA gene resulting in post-translational processing defects that trigger Progeria in children. Werner syndrome, arising from mutations in the WRN helicase gene, causes premature aging in young adults. What are the molecular mechanism(s) underlying these disorders and what aspects of the diseases resemble physiological human aging? Much of what we know stems from the study of patient derived fibroblasts with both mutations resulting in increased DNA damage, primarily at telomeres. However, in vivo patients with Werner's develop arteriosclerosis, among other pathologies. In HGPS patients, including iPS derived cells from HGPS patients, as well as some mouse models for Progeria, vascular smooth muscle (VSM) appears to be among the most severely affected tissues. Defective Lamin processing, associated with DNA damage, is present in VSM from old individuals, indicating processing defects may be a factor in normal aging. Whether persistent DNA damage, particularly at telomeres, is the root cause for these pathologies remains to be established, since not all progeroid Lmna mutations result in DNA damage and genome instability.

  3. Tracking accelerated aging of composites with ultrasonic attenuation measurements

    SciTech Connect

    Chinn, D.J.; Durbin, P.F.; Thomas, G.H.; Groves, S.E.

    1996-10-01

    Composite materials are steadily replacing traditional materials in many industries. For many carbon composite materials, particularly in aerospace applications, durability is a critical design parameter which must be accurately characterized. Lawrence Livermore National Laboratory (LLNL) and Boeing Commercial Airplane Group have established a cooperative research and development agreement (CRADA) to assist in the high speed research program at Boeing. LLNL`s expertise in fiber composites, computer modeling, mechanical testing, chemical analysis and nondestructive evaluation (ND) will contribute to the study of advanced composite materials in commercial aerospace applications. Through thermo-mechanical experiments with periodic chemical analysis and nondestructive evaluation, the aging mechanisms in several continuous fiber polymer composites will be studied. Several measurement techniques are being studied for their correlation with aging. This paper describes through-transmission ultrasonic attenuation measurements of isothermally aged composite materials and their use as a tracking parameter for accelerated aging.

  4. Diagnostics for advanced laser acceleration experiments

    SciTech Connect

    Misuri, Alessio

    2002-06-01

    The first proposal for plasma based accelerators was suggested by 1979 by Tajima and Dawson. Since then there has been a tremendous progress both theoretically and experimentally. The theoretical progress is particularly due to the growing interest in the subject and to the development of more accurate numerical codes for the plasma simulations (especially particle-in-cell codes). The experimental progress follows from the development of multi-terawatt laser systems based on the chirped-pulse amplification technique. These efforts have produced results in several experiments world-wide, with the detection of accelerated electrons of tens of MeV. The peculiarity of these advanced accelerators is their ability to sustain extremely large acceleration gradients. In the conventional radio frequency linear accelerators (RF linacs) the acceleration gradients are limited roughly to 100 MV/m; this is partially due to breakdown which occurs on the walls of the structure. The electrical breakdown is originated by the emission of the electrons from the walls of the cavity. The electrons cause an avalanche breakdown when they reach other metal parts of the RF linacs structure.

  5. Accelerated optical polymer aging studies for LED luminaire applications

    NASA Astrophysics Data System (ADS)

    Estupiñán, Edgar; Wendling, Peter; Kostrun, Marijan; Garner, Richard

    2013-09-01

    There is a need in the lighting industry to design and implement accelerated aging methods that accurately simulate the aging process of LED luminaire components. In response to this need, we have built a flexible and reliable system to study the aging characteristics of optical polymer materials, and we have employed it to study a commercially available LED luminaire diffuser made of PMMA. The experimental system consists of a "Blue LED Emitter" and a working surface. Both the temperatures of the samples and the optical powers of the LEDs are appropriately characterized in the system. Several accelerated aging experiments are carried out at different temperatures and optical powers over a 90 hour period and the measured transmission values are used as inputs to a degradation model derived using plausibility arguments. This model seems capable of predicting the behavior of the material as a function of time, temperature and optical power. The model satisfactorily predicts the measured transmission values of diffusers aged in luminaires at two different times and thus can be used to make application recommendations for this material. Specifically, at 35000 hours (the manufacturer's stated life of the luminaire) and at the typical operational temperature of the diffuser, the model predicts a transmission loss of only a few percent over the original transmission of the material at 450 nm, which renders this material suitable for this application.

  6. Accelerator/Experiment operations - FY 2006

    SciTech Connect

    Brice, S.; Conrad, J.; Denisov, D.; Ginther, G.; Holmes, S.; James, C.; Lee, W.; Louis, W.; Moore, C.; Plunkett, R.; Raja, R.; /Fermilab

    2006-10-01

    This Technical Memorandum (TM) summarizes the Fermilab accelerator and experiment operations for FY 2006. It is one of a series of annual publications intended to gather information in one place. In this case, the information concerns the FY 2006 Run II at the Tevatron Collider, the MiniBooNE experiments running in the Booster Neutrino Beam in neutrino and antineutrino modes, MINOS using the Main Injector Neutrino Beam (NuMI), and SY 120 activities.

  7. Space Experiments with Particle Accelerators (SEPAC)

    NASA Technical Reports Server (NTRS)

    Obayashi, Tatsuzo

    1988-01-01

    The purpose of Space Experiments with Particle Accelerators (SEPAC) on the Atmospheric Laboratory for Applications and Science (ATLAS 1) mission, is to carry out active and interactive experiments on and in the earth's ionosphere, atmosphere, and magnetosphere. The instruments to be used are an electron beam accelerator (EBA), plasma contactor, and associated instruments the purpose of which is to perform diagnostic, monitoring, and general data taking functions. Four major classes of investigations are to be performed by SEPAC. They are: beam plasma physics, beam-atmosphere interactions, the use of modulated electron beams as transmitting antennas, and the use of electron beams for remote sensing of electric and magnetic fields. The first class consists mainly of onboard plasma physics experiments to measure the effects of phenomena in the vicinity of the shuttle. The last three are concerned with remote effects and are supported by other ATLAS 1 investigations as well as by ground-based observations.

  8. High temperature experiment for accelerator inertial fusion

    SciTech Connect

    Lee, E.P.

    1985-05-01

    The High Temperature Experiment (HTE) is intended to produce temperatures of 50 to 100 eV in solid density targets driven by heavy ion beams from a multiple beam induction linac. The fundamental variables (particle species, energy, number of beamlets, current and pulse length) must be fixed to achieve the temperature at minimum cost, subject to criteria of technical feasibility and relevance to the development of a Fusion Driver. The conceptual design begins with an assumed (radiation-limited) target temperature and uses limitations due to particle range, beamlet perveance, and target disassembly to bound the allowable values of mass number (A) and energy (E). An accelerator model is then applied to determine the minimum length accelerator, which is a guide to total cost. The accelerator model takes into account limits on transportable charge, maximum gradient, core mass per linear meter, and head-to-tail momentum variation within a pulse.

  9. Accelerator/Experiment Operations - FY 2015

    SciTech Connect

    Czarapata, P.

    2015-10-01

    This Technical Memorandum summarizes the Fermilab accelerator and experiment operations for FY 2015. It is one of a series of annual publications intended to gather information in one place. In this case, the information concerns the FY 2015 NOvA, MINOS+ and MINERvA experiments using the Main Injector Neutrino Beam (NuMI), the activities in the SciBooNE Hall using the Booster Neutrino Beam (BNB), and the SeaQuest experiment and Meson Test Beam (MTest) activities in the 120 GeV external Switchyard beam (SY120).

  10. Space experiments with particle accelerators. [Spacelab

    NASA Technical Reports Server (NTRS)

    Obayashi, T.

    1981-01-01

    The purpose of space experiments with particle accelerators (SEPAC) is to carry out active and interactive experiments on and in the Earth's ionosphere and magnetosphere. It is also intended to make an initial performance test for an overall program of Spacelab/SEPAC experiments. The instruments to be used are an electron beam accelerator, magnetoplasma dynamic arcjet, and associated diagnostic equipment. The accelerators are installed on the pallet, with monitoring and diagnostic observations being made by the gas plume release, beam-monitor TV, and particle-wave measuring instruments also mounted on the pallet. Command and display systems are installed in the module. Three major classes of investigations to be performed are vehicle charge neutralization, beam plasma physics, and beam atmosphere interactions. The first two are mainly onboard plasma physics experiments to measure the effect of phenomena in the vicinity of Spacelab. The last one is concerned with atmospheric modification and is supported by other Spacelab 1 investigations as well as by ground-based, remote sensing observations.

  11. The FAST (FRC Acceleration Space Thruster) Experiment

    NASA Technical Reports Server (NTRS)

    Martin, Adam; Eskridge, R.; Lee, M.; Richeson, J.; Smith, J.; Thio, Y. C. F.; Slough, J.; Rodgers, Stephen L. (Technical Monitor)

    2001-01-01

    The Field Reverse Configuration (FRC) is a magnetized plasmoid that has been developed for use in magnetic confinement fusion. Several of its properties suggest that it may also be useful as a thruster for in-space propulsion. The FRC is a compact toroid that has only poloidal field, and is characterized by a high plasma beta = (P)/(B (sup 2) /2Mu0), the ratio of plasma pressure to magnetic field pressure, so that it makes efficient use of magnetic field to confine a plasma. In an FRC thruster, plasmoids would be repetitively formed and accelerated to high velocity; velocities of = 250 km/s (Isp = 25,000s) have already been achieved in fusion experiments. The FRC is inductively formed and accelerated, and so is not subject to the problem of electrode erosion. As the plasmoid may be accelerated over an extended length, it can in principle be made very efficient. And the achievable jet powers should be scalable to the MW range. A 10 kW thruster experiment - FAST (FRC Acceleration Space Thruster) has just started at the Marshall Space Flight Center. The design of FAST and the status of construction and operation will be presented.

  12. Orbital Acceleration Research Experiment: Calibration Measurements

    NASA Technical Reports Server (NTRS)

    Blanchard, Robert C.; Nicholson, John Y.; Ritter, James R.; Larman, Kevin T.

    1995-01-01

    The Orbital Acceleration Research Experiment (OARE), which has flown on STS-40, STS-50, and STS-58, contains a three-axis accelerometer with a single, nonpendulous, electrostatically suspended proofmass, which can resolve accelerations to the 10(sub -9) g level. The experiment also contains a full calibration station to permit in situ bias and scale-factor calibration. This on-orbit calibration capability eliminates the large uncertainty of ground-based calibrations encountered with accelerometers flown in the past on the Orbiter, and thus provides absolute acceleration measurement accuracy heretofore unachievable. This is the first time accelerometer scale-factor measurements have been performed on orbit. A detailed analysis of the calibration process is given, along with results of the calibration factors from the on-orbit OARE flight measurements on STS-58. In addition, the analysis of OARE flight-maneuver data used to validate the scale-factor measurements in the sensor's most sensitive range are also presented. Estimates on calibration uncertainties are discussed. These uncertainty estimates provides bounds on the STS-58 absolute acceleration measurements for future applications.

  13. Space Experiments with Particle Accelerators: SEPAC

    NASA Technical Reports Server (NTRS)

    Burch, J. L.; Roberts, W. T.; Taylor, W. W. L.; Kawashima, N.; Marshall, J. A.; Moses, S. L.; Neubert, T.; Mende, S. B.; Choueiri, E. Y.

    1994-01-01

    The Space Experiments with Particle Accelerators (SEPAC), which flew on the Atmospheric Laboratory for Applications and Science (ATLAS) 1 mission, used new techniques to study natural phenomena in the Earth's upper atmosphere, ionosphere and magnetosphere by introducing energetic perturbations into the system from a high power electron beam with known characteristics. Properties of auroras were studied by directing the electron beam into the upper atmosphere while making measurements of optical emissions. Studies were also performed of the critical ionization velocity phenomenon.

  14. Accelerator-based neutrino oscillation experiments

    SciTech Connect

    Harris, Deborah A.; /Fermilab

    2007-12-01

    Neutrino oscillations were first discovered by experiments looking at neutrinos coming from extra-terrestrial sources, namely the sun and the atmosphere, but we will be depending on earth-based sources to take many of the next steps in this field. This article describes what has been learned so far from accelerator-based neutrino oscillation experiments, and then describe very generally what the next accelerator-based steps are. In section 2 the article discusses how one uses an accelerator to make a neutrino beam, in particular, one made from decays in flight of charged pions. There are several different neutrino detection methods currently in use, or under development. In section 3 these are presented, with a description of the general concept, an example of such a detector, and then a brief discussion of the outstanding issues associated with this detection technique. Finally, section 4 describes how the measurements of oscillation probabilities are made. This includes a description of the near detector technique and how it can be used to make the most precise measurements of neutrino oscillations.

  15. Subjective acceleration of time experience in everyday life across adulthood.

    PubMed

    John, Dennis; Lang, Frieder R

    2015-12-01

    Most people believe that time seems to pass more quickly as they age. Building on assumptions of socioemotional selectivity theory, we investigated whether awareness that one's future lifetime is limited is associated with one's experience of time during everyday activities across adulthood in 3 studies. In the first 2 studies (Study 1: N = 608; Study 2: N = 398), participants completed a web-based version of the day reconstruction method. In Study 3 (N = 392) participants took part in a newly developed tomorrow construction method, a web-based experimental method for assessing everyday life plans. Results confirmed that older adults' subjective interpretation of everyday episodes is that these episodes pass more quickly compared with younger adults. The subjective acceleration of time experience in old age was more pronounced during productive activities than during regenerative-consumptive activities. The age differences were partly related to limited time remaining in life. In addition, subjective acceleration of time experience was associated with positive evaluations of everyday activities. Findings suggest that subjective acceleration of time in older adults' daily lives reflects an adaptation to limitations in time remaining in life. (PsycINFO Database Record

  16. Magnetically accelerated foils for shock wave experiments

    NASA Astrophysics Data System (ADS)

    Neff, Stephan; Ford, Jessica; Martinez, David; Plechaty, Christopher; Wright, Sandra; Presura, Radu

    2008-04-01

    The interaction of shock waves with inhomogeneous media is important in many astrophysical problems, e.g. the role of shock compression in star formation. Using scaled experiments with inhomogeneous foam targets makes it possible to study relevant physics in the laboratory, to better understand the mechanisms of shock compression and to benchmark astrophysical simulation codes. Experiments with flyer-generated shock waves have been performed on the Z machine in Sandia. The Zebra accelerator at the Nevada Terawatt Facility (NTF) allows for complementary experiments with high repetition rate. First experiments on Zebra demonstrated flyer acceleration to sufficiently high velocities (around 2 km/s) and that laser shadowgraphy can image sound fronts in transparent targets. Based on this, we designed an optimized setup to improve the flyer parameters (higher speed and mass) to create shock waves in transparent media. Once x-ray backlighting with the Leopard laser at NTF is operational, we will switch to foam targets with parameters relevant for laboratory astrophysics.

  17. The LHCf experiment at the LHC accelerator

    SciTech Connect

    Bonechi, L.; Adriani, O.; Bongi, M.; D'Alessandro, R.; Papini, P.; Castellini, G.; Faus, A.; Velasco, J.; Haguenauer, M.; Itow, Y.; Mase, T.; Masuda, K.; Matsubara, Y.; Matsumoto, H.; Menjo, H.; Muraki, Y.; Sako, T.; Tanaka, K.; Watanabe, H.; Kasahara, K.

    2006-10-27

    The claimed discovery of atmospheric shower induced by cosmic-ray with energy beyond the GZK cutoff by the AGASA experiment in 1994-1995, although not confirmed by other important experiments like Fly's Eye and Hi-Res, together with the poor knowledge of the composition of cosmic rays around and beyond the Knee region, have highlighted the necessity of new experiments that should increase our present knowledge of HECR and UHECR. For this reason big efforts have been addressed to the development of new experiments, like Auger, TA and EUSO, for a systematic study of the UHE atmospheric showers with increased capabilities with respect to the previous experiments. Moreover complementary experiments should allow a precise calibration of the methods used for the reconstruction of cosmic-ray showers in atmosphere. Their aim is the measurement of quantities that are used in these procedures and that are not yet precisely known. Under this perspective the LHCf experiment is a compact experiment which has been proposed for the study of neutral pion and gamma production at high energy in proton-proton interaction in the very forward region of the LHC accelerator. It will help calibrating the algorithms that are used to reconstruct the atmospheric shower events for energy beyond the Knee. The LHCf apparatus and the results of the first beam test, held in 2004, are shortly discussed in this work.

  18. Acceleration of the aging process by oxygen

    NASA Technical Reports Server (NTRS)

    Miquel, J.; Lunderen, P. R.; Bensch, K. G.

    1975-01-01

    Tissue changes induced by hyperoxia have been compared with those of normal aging. Results of investigations using male flies prompt conclusion that normal aging, radiation syndrome, and hyperoxic injury share at least one common feature--lipid peroxidation damage to all mambranes resulting in accumulation of age pigment.

  19. Accelerated Aging of the M119 Simulator

    NASA Technical Reports Server (NTRS)

    Bixon, Eric R.

    2000-01-01

    This paper addresses the storage requirement, shelf life, and the reliability of M119 Whistling Simulator. Experimental conditions have been determined and the data analysis has been completed for the accelerated testing of the system. A general methodology to evaluate the shelf life of the system as a function of the storage time, temperature, and relative humidity is discussed.

  20. Choosing experiments to accelerate collective discovery

    SciTech Connect

    Rzhetsky, Andrey; Foster, Jacob G.; Foster, Ian T.; Evans, James A.

    2015-11-24

    Scientists perform a tiny subset of all possible experiments. What characterizes the experiments they choose? What are the consequences of those choices for the pace of scientific discovery? We model scientific knowledge as a network and science as a sequence of experiments designed to gradually uncover it. By analyzing millions of biomedical articles published over 30 y, we find that biomedical scientists pursue conservative research strategies exploring the local neighborhood of central, important molecules. Although such strategies probably serve scientific careers, we show that they slow scientific advance, especially in mature fields, where more risk and less redundant experimentation would accelerate discovery of the network. Lastly, we also consider institutional arrangements that could help science pursue these more efficient strategies.

  1. Choosing experiments to accelerate collective discovery

    DOE PAGES

    Rzhetsky, Andrey; Foster, Jacob G.; Foster, Ian T.; Evans, James A.

    2015-11-24

    Scientists perform a tiny subset of all possible experiments. What characterizes the experiments they choose? What are the consequences of those choices for the pace of scientific discovery? We model scientific knowledge as a network and science as a sequence of experiments designed to gradually uncover it. By analyzing millions of biomedical articles published over 30 y, we find that biomedical scientists pursue conservative research strategies exploring the local neighborhood of central, important molecules. Although such strategies probably serve scientific careers, we show that they slow scientific advance, especially in mature fields, where more risk and less redundant experimentation wouldmore » accelerate discovery of the network. Lastly, we also consider institutional arrangements that could help science pursue these more efficient strategies.« less

  2. Accelerated ageing experiments with crosslinked and conventional ultra-high molecular weight polyethylene (UHMW-PE) stabilised with alpha-tocopherol for total joint arthroplasty.

    PubMed

    Wolf, C; Macho, C; Lederer, K

    2006-12-01

    Samples of untreated ultra-high molecular weight polyethylene (UHMW-PE), UHMW-PE sterilized with gamma-rays in nitrogen atmosphere (conventional UHMW-PE, widely used for articulating surfaces in endoprostheses) and UHMW-PE, which has been crosslinked by electron beam irradiation and annealed subsequently, were stabilized with alpha-tocopherol and aged in air at 120 degrees C as well as in 10% aqueous hydrogenperoxide with 0.04 mg/ml FeCl3 as catalyst at 50 degrees C. The oxidative degradation was monitored with the help of infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), solubility measurements and size exclusion chromatography (SEC) and were compared to unstabilized samples. When aged in air at 120 degrees C, the crosslinked UHMW-PE showed a slightly slower increase of the carbonyl (CO)-number (according to DIN 53383) in FTIR than conventional UHMW-PE. A stabilisation with 0.4% w/w alpha-tocopherol resulted in an increase of lifetime by a factor of approx. 40 for all samples. Ageing in 10% aqueous H2O2 at 50 degrees C yielded similar results for all three unstabilised samples. The addition of the natural antioxidant alpha-tocopherol led to a prolongation of lifetime by a factor of approx. 2.5. A linear loss of alpha-tocopherol was detected during ageing. An increase of crystallinity as well as lamella thickness during ageing was observed with the help of DSC. The two-phase structure of crosslinked UHMW-PE with two melting endotherms at 114 degrees C and 137 degrees C was replaced very quickly by a single melting point at 130 degrees C. This effect was delayed with the stabilized samples. In the solubility and SEC measurements, a severe molecular degradation and drop of molar mass of all materials could be observed after ageing in H2O2, leading to a complete destruction and, in case of crosslinked UHMW-PE, to a serious damage of the molecular network, respectively. PMID:17143765

  3. An Epigenetic Clock Measures Accelerated Aging in Treated HIV Infection.

    PubMed

    Boulias, Konstantinos; Lieberman, Judy; Greer, Eric Lieberman

    2016-04-21

    In this issue of Molecular Cell, Gross et al. (2016) find a CpG DNA methylation signature in blood cells of patients with chronic well-controlled HIV infection that correlates with accelerated aging. PMID:27105110

  4. Magnetically accelerated foils for shock wave experiments

    NASA Astrophysics Data System (ADS)

    Neff, S.; Ford, J.; Wright, S.; Martinez, D.; Plechaty, C.; Presura, R.

    2009-08-01

    Many astrophysical phenomena involve the interaction of a shock wave with an inhomogeneous background medium. Using scaled experiments with inhomogeneous foam targets makes it possible to study relevant physics in the laboratory to better understand the mechanisms of shock compression and to benchmark astrophysical simulation codes. First experiments on Zebra at the Nevada Terawatt Facility (NTF) have demonstrated flyer acceleration to sufficiently high velocities (up to 5 km/s) and that laser shadowgraphy can image sound fronts in transparent targets. Based on this, we designed an optimized setup to improve the flyer parameters (higher speed and mass) to create shock waves in transparent media. Once x-ray backlighting with the Leopard laser at NTF is operational, we will switch to foam targets with parameters relevant for laboratory astrophysics.

  5. Space Experiments with Particle Accelerators (SEPAC)

    NASA Technical Reports Server (NTRS)

    Obayashi, T.; Kawashima, N.; Kuriki, K.; Nagatomo, M.; Ninomiya, K.; Sasaki, S.; Ushirokawa, A.; Kudo, I.; Ejiri, M.; Roberts, W. T.

    1982-01-01

    Plans for SEPAC, an instrument array to be used on Spacelab 1 to study vehicle charging and neutralization, beam-plasma interaction in space, beam-atmospheric interaction exciting artificial aurora and airglow, and the electromagnetic-field configuration of the magnetosphere, are presented. The hardware, consisting of electron beam accelerator, magnetoplasma arcjet, neutral-gas plume generator, power supply, diagnostic package (photometer, plasma probes, particle analyzers, and plasma-wave package), TV monitor, and control and data-management unit, is described. The individual SEPAC experiments, the typical operational sequence, and the general outline of the SEPAC follow-on mission are discussed. Some of the experiments are to be joint ventures with AEPI (INS 003) and will be monitored by low-light-level TV.

  6. E-157: A Plasma Wakefield Acceleration Experiment

    SciTech Connect

    Muggli, Patrick

    2000-10-20

    The E-157 plasma wakefield experiment addresses issues relevant to a meter long plasma accelerator module. In particular, a 1.4 m long plasma source has been developed for the experiment. The transverse dynamics of the beam in the plasma is studied: multiple betatron oscillations of the beam envelope, flipping of the beam tail, stability against the hose instability, emission of synchrotron radiation by the beam in the plasma. The bending of the 28.5 GeV beam at the plasma/vapor interface is observed for the first time. The longitudinal dynamics of the beam, i.e. the energy loss and gain by the electrons in the wake, is strongly affected by the oscillation of the beam tail instability.

  7. Pathology of Mouse Models of Accelerated Aging.

    PubMed

    Harkema, L; Youssef, S A; de Bruin, A

    2016-03-01

    Progeroid mouse models display phenotypes in multiple organ systems that suggest premature aging and resemble features of natural aging of both mice and humans. The prospect of a significant increase in the global elderly population within the next decades has led to the emergence of "geroscience," which aims at elucidating the molecular mechanisms involved in aging. Progeroid mouse models are frequently used in geroscience as they provide insight into the molecular mechanisms that are involved in the highly complex process of natural aging. This review provides an overview of the most commonly reported nonneoplastic macroscopic and microscopic pathologic findings in progeroid mouse models (eg, osteoporosis, osteoarthritis, degenerative joint disease, intervertebral disc degeneration, kyphosis, sarcopenia, cutaneous atrophy, wound healing, hair loss, alopecia, lymphoid atrophy, cataract, corneal endothelial dystrophy, retinal degenerative diseases, and vascular remodeling). Furthermore, several shortcomings in pathologic analysis and descriptions of these models are discussed. Progeroid mouse models are valuable models for aging, but thorough knowledge of both the mouse strain background and the progeria-related phenotype is required to guide interpretation and translation of the pathology data. PMID:26864891

  8. The Argon Geochronology Experiment (AGE)

    NASA Technical Reports Server (NTRS)

    Swindle, T. D.; Bode, R.; Fennema, A.; Chutjian, A.; MacAskill, J. A.; Darrach, M. R.; Clegg, S. M.; Wiens, R. C.; Cremers, D.

    2006-01-01

    This viewgraph presentation reviews the Argon Geochronology Experiment (AGE). Potassium-Argon dating is shown along with cosmic ray dating exposure. The contents include a flow diagram of the Argon Geochronology Experiment, and schematic diagrams of the mass spectrometer vacuum system, sample manipulation mechanism, mineral heater oven, and the quadrupole ion trap mass spectrometer. The Laser-Induced Breakdown Spectroscopy (LIBS) Operation with elemental abundances is also described.

  9. Pulsed power accelerator for material physics experiments

    NASA Astrophysics Data System (ADS)

    Reisman, D. B.; Stoltzfus, B. S.; Stygar, W. A.; Austin, K. N.; Waisman, E. M.; Hickman, R. J.; Davis, J.-P.; Haill, T. A.; Knudson, M. D.; Seagle, C. T.; Brown, J. L.; Goerz, D. A.; Spielman, R. B.; Goldlust, J. A.; Cravey, W. R.

    2015-09-01

    We have developed the design of Thor: a pulsed power accelerator that delivers a precisely shaped current pulse with a peak value as high as 7 MA to a strip-line load. The peak magnetic pressure achieved within a 1-cm-wide load is as high as 100 GPa. Thor is powered by as many as 288 decoupled and transit-time isolated bricks. Each brick consists of a single switch and two capacitors connected electrically in series. The bricks can be individually triggered to achieve a high degree of current pulse tailoring. Because the accelerator is impedance matched throughout, capacitor energy is delivered to the strip-line load with an efficiency as high as 50%. We used an iterative finite element method (FEM), circuit, and magnetohydrodynamic simulations to develop an optimized accelerator design. When powered by 96 bricks, Thor delivers as much as 4.1 MA to a load, and achieves peak magnetic pressures as high as 65 GPa. When powered by 288 bricks, Thor delivers as much as 6.9 MA to a load, and achieves magnetic pressures as high as 170 GPa. We have developed an algebraic calculational procedure that uses the single brick basis function to determine the brick-triggering sequence necessary to generate a highly tailored current pulse time history for shockless loading of samples. Thor will drive a wide variety of magnetically driven shockless ramp compression, shockless flyer plate, shock-ramp, equation of state, material strength, phase transition, and other advanced material physics experiments.

  10. Space Experiments with Particle Accelerators (SEPAC)

    NASA Technical Reports Server (NTRS)

    Taylor, William W. L.

    1994-01-01

    The scientific emphasis of this contract has been on the physics of beam ionosphere interactions, in particular, what are the plasma wave levels stimulated by the Space Experiments with Particle Accelerators (SEPAC) electron beam as it is ejected from the Electron Beam Accelerator (EBA) and passes into and through the ionosphere. There were two different phenomena expected. The first was generation of plasma waves by the interaction of the DC component of the beam with the plasma of the ionosphere, by wave particle interactions. The second was the generation of waves at the pulsing frequency of the beam (AC component). This is referred to as using the beam as a virtual antenna, because the beam of electrons is a coherent electrical current confined to move along the earth's magnetic field. As in a physical antenna, a conductor at a radio or TV station, the beam virtual antenna radiates electromagnetic waves at the frequency of the current variations. These two phenomena were investigated during the period of this contract.

  11. Plasma gun pellet acceleration modeling and experiment

    SciTech Connect

    Kincaid, R.W.; Bourham, M.A.; Gilligan, J.G.

    1996-12-31

    Modifications to the electrothermal plasma gun SIRENS have been completed to allow for acceleration experiments using plastic pellets. Modifications have been implemented to the 1-D, time dependent code ODIN to include pellet friction, momentum, and kinetic energy with options of variable barrel length. The code results in the new version, POSEIDON, compare favorably with experimental data and with code results from ODIN. Predicted values show an increased pellet velocity along the barrel length, achieving 2 km/s exit velocity. Measured velocity, at three locations along the barrel length, showed good correlation with predicted values. The code has also been used to investigate the effectiveness of longer pulse length on pellet velocity using simulated ramp up and down currents with flat top, and triangular current pulses with early and late peaking. 16 refs., 5 figs.

  12. Aging of organic materials around high-energy particle accelerators

    NASA Astrophysics Data System (ADS)

    Tavlet, Marc

    1997-08-01

    Around particle accelerators used for fundamental research on the basic structure of matter, materials and components are exposed to ionizing radiation caused by beam losses in the proton machines and by synchrotron radiation in the lepton machines. Furthermore, with the high-energy and high-intensity collisions produced from future colliders, radiation damage is also to be expected in particle-physics detectors. Therefore, for a safe and reliable operation, the radiation aging of most of the components has to be assessed prior to their selection. An extensive radiation-damage test program has been carried out at CERN for decades on a routine basis and many results have been published. The tests have mainly concentrated on magnet-coil insulations and cable-insulating materials; they are carried out in accordance with the IEC 544 standard which defines the mechanical tests to be performed and the methods of degradation evaluation. The mechanical tests are also used to assess the degradation of composite structural materials. Moreover, electrical properties of high-voltage insulations and optical properties of organic scintillators and wave guides have also been studied. Our long-term experience has pointed out many parameters to be taken into account for the estimate of the lifetime of components in the radiation environment of our accelerators. One of the main parameters is the dose-rate effect, but the influence of other parameters has sometimes to be taken into account.

  13. Disk Acceleration Experiment Utilizing Minimal Material (DAXUMM)

    NASA Astrophysics Data System (ADS)

    Biss, Matthew; Lorenz, Thomas; Sutherland, Gerrit

    2015-06-01

    A venture between the US Army Research Laboratory (ARL) and Lawrence Livermore National Laboratory (LLNL) is currently underway in an effort to characterize novel energetic material performance properties using a single, high-precision, gram-range charge. A nearly all-inclusive characterization experiment is proposed by combing LLNL's disk acceleration experiment (DAX) with the ARL explosive evaluation utilizing minimal material (AXEUMM) experiment. Spherical-cap charges fitted with a flat circular metal disk are centrally initiated using an exploding bridgewire detonator while photonic doppler velocimetry is used to probe the metal disk surface velocity and measure its temporal history. The metal disk's jump-off-velocity measurement is combined with conservation equations, material Hugoniots, and select empirical relationships to determine performance properties of the detonation wave (i.e., velocity, pressure, particle velocity, and density). Using the temporal velocity history with the numerical hydrocode CTH, a determination of the energetic material's equation of state and material expansion energy is possible. Initial experimental and computational results for the plastic-bonded energetic formulation PBXN-5 are presented.

  14. Nylon 6.6 accelerated aging studies : thermal-oxidative degradation and its interaction with hydrolysis.

    SciTech Connect

    Bernstein, Robert; Derzon, Dora Kay; Gillen, Kenneth T.

    2004-06-01

    Accelerated aging of Nylon 6.6 fibers used in parachutes has been conducted by following the tensile strength loss under both thermal-oxidative and 100% relative humidity conditions. Thermal-oxidative studies (air circulating ovens) were performed for time periods of weeks to years at temperatures ranging from 37 C to 138 C. Accelerated aging humidity experiments (100% RH) were performed under both an argon atmosphere to examine the 'pure' hydrolysis pathway, and under an oxygen atmosphere (oxygen partial pressure close to that occurring in air) to mimic true aging conditions. As expected the results indicated that degradation caused by humidity is much more important than thermal-oxidative degradation. Surprisingly when both oxygen and humidity were present the rate of degradation was dramatically enhanced relative to humidity aging in the absence of oxygen. This significant and previously unknown phenomena underscores the importance of careful accelerated aging that truly mimics real world storage conditions.

  15. Accelerated thermal and radiative ageing of hydrogenated NBR for DRC

    SciTech Connect

    Mares, G.; Notingher, P.

    1996-12-31

    The accelerated thermal and gamma radiation ageing of HNBR carbon black-T80 has been studied by measuring the residual deformation under constant deflection -- DRC, in air, using a relevant equation for the relaxation phenomena. The residual deformation under constant deflection during the process of accelerated ageing is increasing but the structure of polymer answers in the proper manner to the mechanical stress. The degradation equations were obtained, using Alfrey model for the relaxation polymer subject to compression and an Arrhenius dependence for the chemical reaction rate. The inverted relaxation time for the thermal degradation is depending on the chemical reaction rate and the dose rate of gamma radiation.

  16. Energy deposition via magnetoplasmadynamic acceleration: I. Experiment

    NASA Astrophysics Data System (ADS)

    Gilland, James; Mikellides, Pavlos; Marriott, Darin

    2009-02-01

    The expansion of a high-temperature fusion plasma through an expanding magnetic field is a process common to most fusion propulsion concepts. The propulsive efficiency of this process has a strong bearing on the overall performance of fusion propulsion. In order to simulate the expansion of a fusion plasma, a concept has been developed in which a high velocity plasma is first stagnated in a converging magnetic field to high (100s of eV) temperatures, then expanded though a converging/diverging magnetic nozzle. As a first step in constructing this experiment, a gigawatt magnetoplasmadynamic plasma accelerator was constructed to generate the initial high velocity plasma and has been characterized. The source is powered by a 1.6 MJ, 1.6 ms pulse forming network. The device has been operated with currents up to 300 kA and power levels up to 200 MWe. These values are among the highest levels reached in an magnetoplasmadynamic thruster. The device operation has been characterized by quasi-steady voltage and current measurements for helium mass flow rates from 0.5 to 27 g s-1. Probe results for downstream plasma density and electron temperature are also presented. The source behavior is examined in terms of current theories for magnetoplasmadynamic thrusters.

  17. Accelerated aging and flashover tests on 138 kV nonceramic line post insulators

    SciTech Connect

    Schneider, H.M.; Guidi, W.W. ); Burnham, J.T. ); Gorur, R.S. ); Hall, J.F. )

    1993-01-01

    The behavior of 138 kV nonceramic line post insulators is investigated by means of clean fog tests conducted before and after aging in a specially designed accelerated aging chamber. The laboratory aging cycles are justified on the basis of actual weather in the coastal regions of Florida. Analytical measurements quantifying the degree of artificial aging are discussed and comparisons of artificial aging with service experience are presented. Observations of audible noise and radio influence voltage during the clean fog tests are reported.

  18. Accelerated aging studies and environmental stability of prototype tamper tapes

    SciTech Connect

    Wright, B.W.; Wright, C.W.; Bunk, A.R.

    1995-05-01

    This report describes the results of accelerated aging experiments (weathering) conducted on prototype tamper tapes bonded to a variety of surface materials. The prototype tamper tapes were based on the patented Confirm{reg_sign} tamper-indicating technology developed and produced by 3M Company. Tamper tapes bonded to surfaces using pressure sensitive adhesive (PSA) and four rapid-set adhesives were evaluated. The configurations of the PSA-bonded tamper tapes were 1.27-cm-wide Confirm{reg_sign} 1700 windows with vinyl underlay and 2.54-cm-wide Confirm{reg_sign} 1700 windows with vinyl and polyester underlays. The configurations of the rapid-set adhesive-bonded tamper tapes were 2.54-cm-wide Confirm{reg_sign} (1700, 1500 with and without primer, and 1300) windows with vinyl underlay. Surfaces used for bonding included aluminum, steel, stainless steel, Kevlar{reg_sign}, brass, copper, fiberglass/resin with and without gel coat, polyurethane-painted steel, acrylonitrile:butadiene:styrene plastic, polyester fiberglass board, Lexan polycarbonate, and cedar wood. Weathering conditions included a QUV cabinet (ultraviolet light at 60{degrees}C, condensing humidity at 40{degrees}C), a thermal cycling cabinet (-18{degrees}C to 46{degrees}C), a Weather-O-Meter (Xenon lamp), and exposure outdoors in Daytona Beach, Florida. Environmental aging exposures lasted from 7 weeks to 5 months. After exposure, the tamper tapes were visually examined and tested for transfer resistance. Tamper tapes were also exposed to a variety of chemical liquids (including organic solvents, acids, bases, and oxidizing liquids) to determine chemical resistance and to sand to determine abrasion resistance.

  19. Accelerated aging of GaAs concentrator solar cells

    SciTech Connect

    Gregory, P.E.

    1982-04-01

    An accelerated aging study of AlGaAs/GaAs solar cells has been completed. The purpose of the study was to identify the possible degradation mechanisms of AlGaAs/GaAs solar cells in terrestrial applications. Thermal storage tests and accelerated AlGaAs corrosion studies were performed to provide an experimental basis for a statistical analysis of the estimated lifetime. Results of this study suggest that a properly designed and fabricated AlGaAs/GaAs solar cell can be mechanically rugged and environmentally stable with projected lifetimes exceeding 100 years.

  20. Cognitive deterioration in adult epilepsy: Does accelerated cognitive ageing exist?

    PubMed

    Breuer, L E M; Boon, P; Bergmans, J W M; Mess, W H; Besseling, R M H; de Louw, A; Tijhuis, A G; Zinger, S; Bernas, A; Klooster, D C W; Aldenkamp, A P

    2016-05-01

    A long-standing concern has been whether epilepsy contributes to cognitive decline or so-called 'epileptic dementia'. Although global cognitive decline is generally reported in the context of chronic refractory epilepsy, it is largely unknown what percentage of patients is at risk for decline. This review is focused on the identification of risk factors and characterization of aberrant cognitive trajectories in epilepsy. Evidence is found that the cognitive trajectory of patients with epilepsy over time differs from processes of cognitive ageing in healthy people, especially in adulthood-onset epilepsy. Cognitive deterioration in these patients seems to develop in a 'second hit model' and occurs when epilepsy hits on a brain that is already vulnerable or vice versa when comorbid problems develop in a person with epilepsy. Processes of ageing may be accelerated due to loss of brain plasticity and cognitive reserve capacity for which we coin the term 'accelerated cognitive ageing'. We believe that the concept of accelerated cognitive ageing can be helpful in providing a framework understanding global cognitive deterioration in epilepsy.

  1. Cognitive deterioration in adult epilepsy: Does accelerated cognitive ageing exist?

    PubMed

    Breuer, L E M; Boon, P; Bergmans, J W M; Mess, W H; Besseling, R M H; de Louw, A; Tijhuis, A G; Zinger, S; Bernas, A; Klooster, D C W; Aldenkamp, A P

    2016-05-01

    A long-standing concern has been whether epilepsy contributes to cognitive decline or so-called 'epileptic dementia'. Although global cognitive decline is generally reported in the context of chronic refractory epilepsy, it is largely unknown what percentage of patients is at risk for decline. This review is focused on the identification of risk factors and characterization of aberrant cognitive trajectories in epilepsy. Evidence is found that the cognitive trajectory of patients with epilepsy over time differs from processes of cognitive ageing in healthy people, especially in adulthood-onset epilepsy. Cognitive deterioration in these patients seems to develop in a 'second hit model' and occurs when epilepsy hits on a brain that is already vulnerable or vice versa when comorbid problems develop in a person with epilepsy. Processes of ageing may be accelerated due to loss of brain plasticity and cognitive reserve capacity for which we coin the term 'accelerated cognitive ageing'. We believe that the concept of accelerated cognitive ageing can be helpful in providing a framework understanding global cognitive deterioration in epilepsy. PMID:26900650

  2. Accelerated aging test results for aerospace wire insulation constructions

    NASA Technical Reports Server (NTRS)

    Dunbar, William G.

    1995-01-01

    Several wire insulation constructions were evaluated with and without continuous glow discharges at low pressure and high temperature to determine the aging characteristics of acceptable wire insulation constructions. It was known at the beginning of the test program that insulation aging takes several years when operated at normal ambient temperature and pressure of 20 C and 760 torr. Likewise, it was known that the accelerated aging process decreases insulation life by approximately 50% for each 10 C temperature rise. Therefore, the first phases of the program, not reported in these test results, were to select wire insulation constructions that could operate at high temperature and low pressure for over 10,000 hours with negligible shrinkage and little materials' deterioration.The final phase of the program was to determine accelerated aging characteristics. When an insulation construction is subjected to partial discharges the insulation is locally heated by the bombardment of the discharges, the insulation is also subjected to ozone and other deteriorating gas particles that may significantly increase the aging process. Several insulation systems using either a single material or combinations of teflon, kapton, and glass insulation constructions were tested. All constructions were rated to be partial discharge and/or corona-free at 240 volts, 400 Hz and 260 C (500 F) for 50, 000 hours at altitudes equivalent to the Paschen law. Minimum partial discharge aging tests were preceded by screening tests lasting 20 hours at 260 C. The aging process was accelerated by subjecting the test articles to temperatures up to 370 C (700 F) with and without partial discharges. After one month operation with continuous glow discharges surrounding the test articles, most insulation systems were either destroyed or became brittle, cracked, and unsafe for use. Time with space radiation as with partial discharges is accumulative.

  3. Accelerated aging and stabilization of radiation-vulcanized EPDM rubber

    NASA Astrophysics Data System (ADS)

    Basfar, A. A.; Abdel-Aziz, M. M.; Mofti, S.

    2000-03-01

    The effect of different antioxidants and their mixtures on the thermal aging and accelerated weathering of γ-radiation vulcanized EPDM rubber in presence of crosslinking coagent, was investigated. The compounds used were either a synergistic blend of phenolic and phosphite antioxidants, i.e. 1:4 Irganox 1076: Irgafos 168 or a blend of arylamine and quinoline type antioxidants, i.e. 1:1 IPPD: TMQ, at fixed concentration. Tinuvin 622 LD hindered amine light stabilized (HALS) was also used. The response was evaluated by the tensile strength and elongation at break for irradiated samples after thermal aging at 100°C for 28 days and accelerated weathering (Xenon test) up to 200 h.

  4. Inverse Cherenkov and inverse FEL accelerator experiments at the Brookhaven Accelerator Test Facility

    SciTech Connect

    Pogorelsky, I.V.; vanSteenbergen, A.; Babzien, M.

    1995-12-31

    Status update on the ongoing inverse Cherenkov acceleration experiment and prospects to its 100 MeV short-term upgrade. The first report on 1 MeV electron acceleration with the 0.5 GW CO{sub 2} laser used in the inverse FEL scheme. (author). 22 refs., 8 figs., 1 tab.

  5. TeV/m Nano-Accelerator: Current Status of CNT-Channeling Acceleration Experiment

    SciTech Connect

    Shin, Young Min; Lumpkin, Alex H.; Thangaraj, Jayakar Charles; Thurman-Keup, Randy Michael; Shiltsev, Vladimir D.

    2014-09-17

    Crystal channeling technology has offered various opportunities in the accelerator community with a viability of ultrahigh gradient (TV/m) acceleration for future HEP collider. The major challenge of channeling acceleration is that ultimate acceleration gradients might require a high power driver in the hard x-ray regime (~ 40 keV). This x-ray energy exceeds those for x-rays as of today, although x-ray lasers can efficiently excite solid plasma and accelerate particles inside a crystal channel. Moreover, only disposable crystal accelerators are possible at such high externally excited fields which would exceed the ionization thresholds destroying the atomic structure, so acceleration will take place only in a short time before full dissociation of the lattice. Carbon-based nanostructures have great potential with a wide range of flexibility and superior physical strength, which can be applied to channeling acceleration. This paper presents a beam- driven channeling acceleration concept with CNTs and discusses feasible experiments with the Advanced Superconducting Test Accelerator (ASTA) in Fermilab.

  6. Electrochemical migration technique to accelerate ageing of cementitious materials

    NASA Astrophysics Data System (ADS)

    Babaahmadi, A.; Tang, L.; Abbas, Z.

    2013-07-01

    Durability assessment of concrete structures for constructions in nuclear waste repositories requires long term service life predictions. As deposition of low and intermediate level radioactive waste (LILW) takes up to 100 000 years, it is necessary to analyze the service life of cementitious materials in this time perspective. Using acceleration methods producing aged specimens would decrease the need of extrapolating short term data sets. Laboratory methods are therefore, needed for accelerating the ageing process without making any influencing distortion in the properties of the materials. This paper presents an electro-chemical migration method to increase the rate of calcium leaching from cementitious specimens. This method is developed based on the fact that major long term deterioration process of hardened cement paste in concrete structures for deposition of LILW is due to slow diffusion of calcium ions. In this method the cementitious specimen is placed in an electrochemical cell as a porous path way through which ions can migrate at a rate far higher than diffusion process. The electrical field is applied to the cell in a way to accelerate the ion migration without making destructions in the specimen's micro and macroscopic properties. The anolyte and catholyte solutions are designed favoring dissolution of calcium hydroxide and compensating for the leached calcium ions with another ion like lithium.

  7. Towards Accelerated Aging Methodologies and Health Management of Power MOSFETs (Technical Brief)

    NASA Technical Reports Server (NTRS)

    Celaya, Jose R.; Patil, Nishad; Saha, Sankalita; Wysocki, Phil; Goebel, Kai

    2009-01-01

    Understanding aging mechanisms of electronic components is of extreme importance in the aerospace domain where they are part of numerous critical subsystems including avionics. In particular, power MOSFETs are of special interest as they are involved in high voltage switching circuits such as drivers for electrical motors. With increased use of electronics in aircraft control, it becomes more important to understand the degradation of these components in aircraft specific environments. In this paper, we present an accelerated aging methodology for power MOSFETs that subject the devices to indirect thermal overstress during high voltage switching. During this accelerated aging process, two major modes of failure were observed - latch-up and die attach degradation. In this paper we present the details of our aging methodology along with details of experiments and analysis of the results.

  8. The electron accelerator for the AWAKE experiment at CERN

    NASA Astrophysics Data System (ADS)

    Pepitone, K.; Doebert, S.; Burt, G.; Chevallay, E.; Chritin, N.; Delory, C.; Fedosseev, V.; Hessler, Ch.; McMonagle, G.; Mete, O.; Verzilov, V.; Apsimon, R.

    2016-09-01

    The AWAKE collaboration prepares a proton driven plasma wakefield acceleration experiment using the SPS beam at CERN. A long proton bunch extracted from the SPS interacts with a high power laser and a 10 m long rubidium vapour plasma cell to create strong wakefields allowing sustained electron acceleration. The electron bunch to probe these wakefields is supplied by a 20 MeV electron accelerator. The electron accelerator consists of an RF-gun and a short booster structure. This electron source should provide beams with intensities between 0.1 and 1 nC, bunch lengths between 0.3 and 3 ps and an emittance of the order of 2 mm mrad. The wide range of parameters should cope with the uncertainties and future prospects of the planned experiments. The layout of the electron accelerator, its instrumentation and beam dynamics simulations are presented.

  9. Accelerated aging tests of liners for uranium mill tailings disposal

    SciTech Connect

    Barnes, S.M.; Buelt, J.L.; Hale, V.Q.

    1981-11-01

    This document describes the results of accelerated aging tests to determine the long-term effectiveness of selected impoundment liner materials in a uranium mill tailings environment. The study was sponsored by the US Department of Energy under the Uranium Mill Tailings Remedial Action Project. The study was designed to evaluate the need for, and the performance of, several candidate liners for isolating mill tailings leachate in conformance with proposed Environmental Protection Agency and Nuclear Regulatory Commission requirements. The liners were subjected to conditions known to accelerate the degradation mechanisms of the various liners. Also, a test environment was maintained that modeled the expected conditions at a mill tailings impoundment, including ground subsidence and the weight loading of tailings on the liners. A comparison of installation costs was also performed for the candidate liners. The laboratory testing and cost information prompted the selection of a catalytic airblown asphalt membrane and a sodium bentonite-amended soil for fiscal year 1981 field testing.

  10. Infection susceptibility and immune senescence with advancing age replicated in accelerated aging Lmna(Dhe) mice.

    PubMed

    Xin, Lijun; Jiang, Tony T; Kinder, Jeremy M; Ertelt, James M; Way, Sing Sing

    2015-12-01

    Aging confers increased susceptibility to common pathogens including influenza A virus. Despite shared vulnerability to infection with advancing age in humans and rodents, the relatively long time required for immune senescence to take hold practically restricts the use of naturally aged mice to investigate aging-induced immunological shifts. Here, we show accelerated aging Lmna(Dhe) mice with spontaneous mutation in the nuclear scaffolding protein, lamin A, replicate infection susceptibility, and substantial immune cell shifts that occur with advancing age. Naturally aged (≥ 20 month) and 2- to 3-month-old Lmna(Dhe) mice share near identically increased influenza A susceptibility compared with age-matched Lmna(WT) control mice. Increased mortality and higher viral burden after influenza infection in Lmna(Dhe) mice parallel reduced accumulation of lung alveolar macrophage cells, systemic expansion of immune suppressive Foxp3⁺ regulatory T cells, and skewed immune dominance among viral-specific CD8⁺T cells similar to the immunological phenotype of naturally aged mice. Thus, aging-induced infection susceptibility and immune senescence are replicated in accelerated aging Lmna(Dhe) mice. PMID:26248606

  11. Cerebrolysin Accelerates Metamorphosis and Attenuates Aging-Accelerating Effect of High Temperature in Drosophila Melanogaster

    PubMed Central

    Navrotskaya, V.; Vorobyova, L.; Sharma, H.; Muresanu, D.; Summergrad, P.

    2015-01-01

    Cerebrolysin® (CBL) is a neuroprotective drug used for the treatment of neurodegenerative diseases. CBL’s mechanisms of action remain unclear. Involvement of tryptophan (TRP)–kynurenine (KYN) pathway in neuroprotective effect of CBL might be suggested considering that modulation of KYN pathway of TRP metabolism by CBL, and protection against eclosion defect and prolongation of life span of Drosophila melanogaster with pharmacologically or genetically-induced down-regulation of TRP conversion into KYN. To investigate possible involvement of TRP–KYN pathway in mechanisms of neuroprotective effect of CBL, we evaluated CBL effects on metamorphosis and life span of Drosophila melanogaster maintained at 23 °C and 28 °C ambient temperature. CBL accelerated metamorphosis, exerted strong tendency (p = 0.04) to prolong life span in female but not in male flies, and attenuated aging-accelerating effect of high (28 °C) ambient temperature in both female and male flies. Further research of CBL effects on metamorphosis and resistance to aging-accelerating effect of high temperature might offer new insights in mechanisms of its neuroprotective action and expand its clinical applications. PMID:25798213

  12. Estimates of effects of residual acceleration on USML-1 experiments

    NASA Technical Reports Server (NTRS)

    Naumann, Robert J.

    1995-01-01

    The purpose of this study effort was to develop analytical models to describe the effects of residual accelerations on the experiments to be carried on the first U.S. Microgravity Lab mission (USML-1) and to test the accuracy of these models by comparing the pre-flight predicted effects with the post-flight measured effects. After surveying the experiments to be performed on USML-1, it became evident that the anticipated residual accelerations during the USML-1 mission were well below the threshold for most of the primary experiments and all of the secondary (Glovebox) experiments and that the only set of experiments that could provide quantifiable effects, and thus provide a definitive test of the analytical models, were the three melt growth experiments using the Bridgman-Stockbarger type Crystal Growth Furnace (CGF). This class of experiments is by far the most sensitive to low level quasi-steady accelerations that are unavoidable on space craft operating in low earth orbit. Because of this, they have been the drivers for the acceleration requirements imposed on the Space Station. Therefore, it is appropriate that the models on which these requirements are based are tested experimentally. Also, since solidification proceeds directionally over a long period of time, the solidified ingot provides a more or less continuous record of the effects from acceleration disturbances.

  13. Accelerated ageing: from mechanism to therapy through animal models.

    PubMed

    Osorio, Fernando G; Obaya, Alvaro J; López-Otín, Carlos; Freije, José M P

    2009-02-01

    Ageing research benefits from the study of accelerated ageing syndromes such as Hutchinson-Gilford progeria syndrome (HGPS), characterized by the early appearance of symptoms normally associated with advanced age. Most HGPS cases are caused by a mutation in the gene LMNA, which leads to the synthesis of a truncated precursor of lamin A known as progerin that lacks the target sequence for the metallopotease FACE-1/ZMPSTE24 and remains constitutively farnesylated. The use of Face-1/Zmpste24-deficient mice allowed us to demonstrate that accumulation of farnesylated prelamin A causes severe abnormalities of the nuclear envelope, hyper-activation of p53 signalling, cellular senescence, stem cell dysfunction and the development of a progeroid phenotype. The reduction of prenylated prelamin A levels in genetically modified mice leads to a complete reversal of the progeroid phenotype, suggesting that inhibition of protein farnesylation could represent a therapeutic option for the treatment of progeria. However, we found that both prelamin A and its truncated form progerin can undergo either farnesylation or geranylgeranylation, revealing the need of targeting both activities for an efficient treatment of HGPS. Using Face-1/Zmpste24-deficient mice as model, we found that a combination of statins and aminobisphosphonates inhibits both types of modifications of prelamin A and progerin, improves the ageing-like symptoms of these mice and extends substantially their longevity, opening a new therapeutic possibility for human progeroid syndromes associated with nuclear-envelope defects. We discuss here the use of this and other animal models to investigate the molecular mechanisms underlying accelerated ageing and to test strategies for its treatment.

  14. Spiked Alloy Production for Accelerated Aging of Plutonium

    SciTech Connect

    Wilk, P A; McNeese, J A; Dodson, K E; Williams, W L; Krikorian, O H; Blau, M S; Schmitz, J E; Bajao, F G; Mew, D A; Matz, T E; Torres, R A; Holck, D M; Moody, K J; Kenneally, J M

    2009-07-10

    The accelerated aging effects on weapons grade plutonium alloys are being studied using {sup 238}Pu-enriched plutonium metal to increase the rate of formation of defect structures. Pyrochemical processing methods have been used to produce two {sup 238}Pu-spiked plutonium alloys with nominal compositions of 7.5 wt% {sup 238}Pu. Processes used in the preparation of the alloys include direct oxide reduction of PuO{sub 2} with calcium and electrorefining. Rolled disks were prepared from the spiked alloys for sampling. Test specimens were cut out of the disks for physical property measurements.

  15. Accelerated aging for testing polymeric biomaterials and medical devices.

    PubMed

    Hukins, D W L; Mahomed, A; Kukureka, S N

    2008-12-01

    Elevated temperature is frequently used to accelerate the aging process in polymers that are associated with medical devices and other applications. A common approach is to assume that the rate of aging is increased by a factor of 2(DeltaT/10), where DeltaT is the temperature increase. This result is a mathematical expression of the empirical observation that increasing the temperature by about 10 degrees C roughly doubles the rate of many polymer reactions. It is equivalent to assuming that the aging process is a first order chemical reaction with an activation energy of 10R/log(e)2, where R is the universal gas constant. A better approach would be to determine the activation energy for the process being considered but this is not always practicable. The simple approach does not depend on the temperature increase, provided that it is not so great that it initiates any physical or chemical process that is unlikely to be involved in normal aging. If a temperature increment theta were to increase a given polymer reaction rate n times, then an elevated temperature would increase the rate of aging by a factor of n(DeltaT/theta).

  16. Accelerator Preparations for Muon Physics Experiments at Fermilab

    SciTech Connect

    Syphers, M.J.; /Fermilab

    2009-10-01

    The use of existing Fermilab facilities to provide beams for two muon experiments - the Muon to Electron Conversion Experiment (Mu2e) and the New g-2 Experiment - is under consideration. Plans are being pursued to perform these experiments following the completion of the Tevatron Collider Run II, utilizing the beam lines and storage rings used today for antiproton accumulation without considerable reconfiguration. Operating scenarios being investigated and anticipated accelerator improvements or reconfigurations will be presented.

  17. Inverse-Transition Radiation Laser Acceleration Experiments at SLAC

    SciTech Connect

    Colby, Eric R.; Ischebeck, R.; Mcguinness, C.; Noble, R.J.; Sears, CMS; Siemann, Robert H.; Spencer, James E.; Walz, D.R.; Byer, R.L.; Plettner, T.; /Stanford U., Phys. Dept.

    2008-01-16

    We present a series of laser-driven particle acceleration experiments that are aimed at studying laser-particle acceleration as an inverse-radiation process. To this end we employ a semi-open vacuum setup with a thin planar boundary that interacts with the laser and the electromagnetic field of the electron beam. Particle acceleration from different types of boundaries will be studied and compared to the theoretical expectations from the Inverse-radiation picture and the field path integral method. We plan to measure the particle acceleration effect from transparent, reflective, black, and rough surface boundaries. While the agreement between the two acceleration pictures is straightforward to prove analytically for the transparent and reflective boundaries the equivalence is not clear-cut for the absorbing and rough-surface boundaries. Experimental observation may provide the evidence to distinguish between the models.

  18. Deactivation of Accelerated Engine-Aged and Field-Aged Fe-Zeolite SCR Catalysts

    SciTech Connect

    Toops, Todd J; Nguyen, Ke; Foster, Adam; Bunting, Bruce G; Hagaman, Edward {Ed} W; Jiao, Jian

    2010-01-01

    A single-cylinder diesel engine with an emissions control system - diesel oxidation catalyst (DOC), Fe-zeolite selective catalytic reduction (SCR) catalyst, and diesel particulate filter (DPF) - was used to perform accelerated thermal aging of the SCR catalyst. Cyclic aging is performed at SCR inlet temperatures of 650, 750 and 850 degrees C for up to 50 aging cycles. To assess the validity of the implemented accelerated thermal aging protocol, a field-aged SCR catalyst of similar formulation was also evaluated. The monoliths were cut into sections and evaluated for NO{sub x} performance in a bench-flow reactor. While the rear section of both the field-aged and the accelerated engine-aged SCR catalysts maintained high NO{sub x}conversion, 75-80% at 400 degrees C, the front section exhibited a drastic decrease to only 20-35% at 400 degrees C. This two-tiered deactivation was also observed for field-aged samples that were analyzed in this study. To understand the observed performance changes, thorough materials characterization was performed which revealed two primary degradation mechanisms. The first mechanism is a general Fe-zeolite deterioration which led to surface area losses, dealumination of the zeolite, and Fe{sub 2}O{sub 3} crystal growth. This degradation accelerated above 750 degrees C, and the effects were generally more severe in the front of the catalyst. The second deactivation mechanism is linked to trace levels of Pt that are suspected to be volatizing from the DOC and depositing on the front section of the SCR catalyst. Chemical evidence of this can be seen in the high levels of NH{sub 3} oxidation (80% conversion at 400 degrees C), which coincides with the decrease in performance.

  19. Parasite infection accelerates age polyethism in young honey bees

    PubMed Central

    Lecocq, Antoine; Jensen, Annette Bruun; Kryger, Per; Nieh, James C.

    2016-01-01

    Honey bees (Apis mellifera) are important pollinators and their health is threatened worldwide by persistent exposure to a wide range of factors including pesticides, poor nutrition, and pathogens. Nosema ceranae is a ubiquitous microsporidian associated with high colony mortality. We used lab micro-colonies of honey bees and video analyses to track the effects of N. ceranae infection and exposure on a range of individual and social behaviours in young adult bees. We provide detailed data showing that N. ceranae infection significantly accelerated the age polyethism of young bees, causing them to exhibit behaviours typical of older bees. Bees with high N. ceranae spore counts had significantly increased walking rates and decreased attraction to queen mandibular pheromone. Infected bees also exhibited higher rates of trophallaxis (food exchange), potentially reflecting parasite manipulation to increase colony infection. However, reduction in queen contacts could help bees limit the spread of infection. Such accelerated age polyethism may provide a form of behavioural immunity, particularly if it is elicited by a wide variety of pathogens. PMID:26912310

  20. Parasite infection accelerates age polyethism in young honey bees.

    PubMed

    Lecocq, Antoine; Jensen, Annette Bruun; Kryger, Per; Nieh, James C

    2016-01-01

    Honey bees (Apis mellifera) are important pollinators and their health is threatened worldwide by persistent exposure to a wide range of factors including pesticides, poor nutrition, and pathogens. Nosema ceranae is a ubiquitous microsporidian associated with high colony mortality. We used lab micro-colonies of honey bees and video analyses to track the effects of N. ceranae infection and exposure on a range of individual and social behaviours in young adult bees. We provide detailed data showing that N. ceranae infection significantly accelerated the age polyethism of young bees, causing them to exhibit behaviours typical of older bees. Bees with high N. ceranae spore counts had significantly increased walking rates and decreased attraction to queen mandibular pheromone. Infected bees also exhibited higher rates of trophallaxis (food exchange), potentially reflecting parasite manipulation to increase colony infection. However, reduction in queen contacts could help bees limit the spread of infection. Such accelerated age polyethism may provide a form of behavioural immunity, particularly if it is elicited by a wide variety of pathogens. PMID:26912310

  1. Acrylamide induces accelerated endothelial aging in a human cell model.

    PubMed

    Sellier, Cyril; Boulanger, Eric; Maladry, François; Tessier, Frédéric J; Lorenzi, Rodrigo; Nevière, Rémi; Desreumaux, Pierre; Beuscart, Jean-Baptiste; Puisieux, François; Grossin, Nicolas

    2015-09-01

    Acrylamide (AAM) has been recently discovered in food as a Maillard reaction product. AAM and glycidamide (GA), its metabolite, have been described as probably carcinogenic to humans. It is widely established that senescence and carcinogenicity are closely related. In vitro, endothelial aging is characterized by replicative senescence in which primary cells in culture lose their ability to divide. Our objective was to assess the effects of AAM and GA on human endothelial cell senescence. Human umbilical vein endothelial cells (HUVECs) cultured in vitro were used as model. HUVECs were cultured over 3 months with AAM or GA (1, 10 or 100 μM) until growth arrest. To analyze senescence, β-galactosidase activity and telomere length of HUVECs were measured by cytometry and semi-quantitative PCR, respectively. At all tested concentrations, AAM or GA reduced cell population doubling compared to the control condition (p < 0.001). β-galactosidase activity in endothelial cells was increased when exposed to AAM (≥10 μM) or GA (≥1 μM) (p < 0.05). AAM (≥10 μM) or GA (100 μM) accelerated telomere shortening in HUVECs (p < 0.05). In conclusion, in vitro chronic exposure to AAM or GA at low concentrations induces accelerated senescence. This result suggests that an exposure to AAM might contribute to endothelial aging.

  2. Parasite infection accelerates age polyethism in young honey bees.

    PubMed

    Lecocq, Antoine; Jensen, Annette Bruun; Kryger, Per; Nieh, James C

    2016-02-25

    Honey bees (Apis mellifera) are important pollinators and their health is threatened worldwide by persistent exposure to a wide range of factors including pesticides, poor nutrition, and pathogens. Nosema ceranae is a ubiquitous microsporidian associated with high colony mortality. We used lab micro-colonies of honey bees and video analyses to track the effects of N. ceranae infection and exposure on a range of individual and social behaviours in young adult bees. We provide detailed data showing that N. ceranae infection significantly accelerated the age polyethism of young bees, causing them to exhibit behaviours typical of older bees. Bees with high N. ceranae spore counts had significantly increased walking rates and decreased attraction to queen mandibular pheromone. Infected bees also exhibited higher rates of trophallaxis (food exchange), potentially reflecting parasite manipulation to increase colony infection. However, reduction in queen contacts could help bees limit the spread of infection. Such accelerated age polyethism may provide a form of behavioural immunity, particularly if it is elicited by a wide variety of pathogens.

  3. Ultraweak chemiluminescence of rice seeds during accelerated aging

    NASA Astrophysics Data System (ADS)

    Chen, Wenli; Xing, Da; He, Yonghong

    2002-04-01

    Ultraweak Chemiluminescence (UCL) studies of different aging degree of rice (Oryza sativa L.) seeds stored in a high temperature 40 degree(s)C and high relative humidity 90% environment (0 day, 8 days, 15 days, and 22 days) were carried out. We firstly observed that aging degree of rice seeds was positive correlation with ultraweak chemiluminescence during the early imbibition (0-1h). Addition of water to rice seeds stimulates ultraweak chemiluminescence, the intensity of which depends upon aging degree of seeds. The shorter the seed accelerated aging time was, the higher the intensity of the UCL in the early imbibition period, the lower hydrogen peroxide (H2O2) concentration of rice seeds, the higher percentage seed germination. The germination and superoxide dismutase (SOD) activity of dry rice seeds was obvious positive correlation with the intensity of UCL. While catalase (CAT) activity of rice seeds was determined. Mechanism of ultraweak chemiluminescence was discussed. It was concluded that the store time of rice seeds could be judged from their UCL characters during the early imbibition period, which might be a way to examine vigor of seeds.

  4. Choosing experiments to accelerate collective discovery.

    PubMed

    Rzhetsky, Andrey; Foster, Jacob G; Foster, Ian T; Evans, James A

    2015-11-24

    A scientist's choice of research problem affects his or her personal career trajectory. Scientists' combined choices affect the direction and efficiency of scientific discovery as a whole. In this paper, we infer preferences that shape problem selection from patterns of published findings and then quantify their efficiency. We represent research problems as links between scientific entities in a knowledge network. We then build a generative model of discovery informed by qualitative research on scientific problem selection. We map salient features from this literature to key network properties: an entity's importance corresponds to its degree centrality, and a problem's difficulty corresponds to the network distance it spans. Drawing on millions of papers and patents published over 30 years, we use this model to infer the typical research strategy used to explore chemical relationships in biomedicine. This strategy generates conservative research choices focused on building up knowledge around important molecules. These choices become more conservative over time. The observed strategy is efficient for initial exploration of the network and supports scientific careers that require steady output, but is inefficient for science as a whole. Through supercomputer experiments on a sample of the network, we study thousands of alternatives and identify strategies much more efficient at exploring mature knowledge networks. We find that increased risk-taking and the publication of experimental failures would substantially improve the speed of discovery. We consider institutional shifts in grant making, evaluation, and publication that would help realize these efficiencies.

  5. Choosing experiments to accelerate collective discovery

    PubMed Central

    Rzhetsky, Andrey; Foster, Jacob G.; Foster, Ian T.

    2015-01-01

    A scientist’s choice of research problem affects his or her personal career trajectory. Scientists’ combined choices affect the direction and efficiency of scientific discovery as a whole. In this paper, we infer preferences that shape problem selection from patterns of published findings and then quantify their efficiency. We represent research problems as links between scientific entities in a knowledge network. We then build a generative model of discovery informed by qualitative research on scientific problem selection. We map salient features from this literature to key network properties: an entity’s importance corresponds to its degree centrality, and a problem’s difficulty corresponds to the network distance it spans. Drawing on millions of papers and patents published over 30 years, we use this model to infer the typical research strategy used to explore chemical relationships in biomedicine. This strategy generates conservative research choices focused on building up knowledge around important molecules. These choices become more conservative over time. The observed strategy is efficient for initial exploration of the network and supports scientific careers that require steady output, but is inefficient for science as a whole. Through supercomputer experiments on a sample of the network, we study thousands of alternatives and identify strategies much more efficient at exploring mature knowledge networks. We find that increased risk-taking and the publication of experimental failures would substantially improve the speed of discovery. We consider institutional shifts in grant making, evaluation, and publication that would help realize these efficiencies. PMID:26554009

  6. Facilitating an accelerated experience-based co-design project.

    PubMed

    Tollyfield, Ruth

    This article describes an accelerated experience-based co-design (AEBCD) quality improvement project that was undertaken in an adult critical care setting and the facilitation of that process. In doing so the aim is to encourage other clinical settings to engage with their patients, carers and staff alike and undertake their own quality improvement project. Patient, carer and staff experience and its place in the quality sphere is outlined and the importance of capturing patient, carer and staff feedback established. Experience-based co-design (EBCD) is described along with the recently tested accelerated version of the process. An overview of the project and outline of the organisational tasks and activities undertaken by the facilitator are given. The facilitation of the process and key outcomes are discussed and reflected on. Recommendations for future undertakings of the accelerated process are given and conclusions drawn.

  7. Evidence of accelerated aging among African Americans and its implications for mortality.

    PubMed

    Levine, M E; Crimmins, E M

    2014-10-01

    Blacks experience morbidity and mortality earlier in the life course compared to whites. Such premature declines in health may be indicative of an acceleration of the aging process. The current study uses data on 7644 black and white participants, ages 30 and above, from the third National Health and Nutrition Examination Survey, to compare the biological ages of blacks and whites as indicated from a combination of ten biomarkers and to determine if such differences in biological age relative to chronological age account for racial disparities in mortality. At a specified chronological age, blacks are approximately 3 years older biologically than whites. Differences in biological age between blacks and whites appear to increase up until ages 60-65 and then decline, presumably due to mortality selection. Finally, differences in biological age were found to completely account for higher levels of all-cause, cardiovascular and cancer mortality among blacks. Overall, these results suggest that being black is associated with significantly higher biological age at a given chronological age and that this is a pathway to early death both overall and from the major age-related diseases.

  8. Induction Accelerator Technology Choices for the Integrated Beam Experiment (IBX)

    SciTech Connect

    Leitner, M.A.; Celata, C.M.; Lee, E.P.; Logan, B.G.; Sabbi, G.; Waldron, W.L.; Barnard, J.J.

    2003-09-15

    Over the next three years the research program of the Heavy Ion Fusion Virtual National Laboratory (HIF-VNL), a collaboration among LBNL, LLNL, and PPPL, is focused on separate scientific experiments in the injection, transport and focusing of intense heavy ion beams at currents from 100 mA to 1 A. As a next major step in the HIF-VNL program, we aim for a complete 'source-to-target' experiment, the Integrated Beam Experiment (IBX). By combining the experience gained in the current separate beam experiments IBX would allow the integrated scientific study of the evolution of a single heavy ion beam at high current ({approx}1 A) through all sections of a possible heavy ion fusion accelerator: the injection, acceleration, compression, and beam focusing.This paper describes the main parameters and technology choices of the planned IBX experiment. IBX will accelerate singly charged potassium or argon ion beams up to 10 MeV final energy and a longitudinal beam compression ratio of 10, resulting in a beam current at target of more than 10 Amperes. Different accelerator cell design options are described in detail: Induction cores incorporating either room temperature pulsed focusing-magnets or superconducting magnets.

  9. Space experiments with particle accelerators (SEPAC): Description of instrumentation

    NASA Technical Reports Server (NTRS)

    Taylor, W. W. L.; Roberts, W. T.; Reasoner, D. L.; Chappell, C. R.; Baker, B. B.; Burch, J. L.; Gibson, W. C.; Black, R. K.; Tomlinson, W. M.; Bounds, J. R.

    1987-01-01

    SEPAC (Space Experiments with Particle Accelerators) flew on Spacelab 1 (SL 1) in November and December 1983. SEPAC is a joint U.S.-Japan investigation of the interaction of electron, plasma, and neutral beams with the ionosphere, atmosphere and magnetosphere. It is scheduled to fly again on Atlas 1 in August 1990. On SL 1, SEPAC used an electron accelerator, a plasma accelerator, and neutral gas source as active elements and an array of diagnostics to investigate the interactions. For Atlas 1, the plasma accelerator will be replaced by a plasma contactor and charge collection devices to improve vehicle charging meutralization. This paper describes the SEPAC instrumentation in detail for the SL 1 and Atlas 1 flights and includes a bibliography of SEPAC papers.

  10. Accelerated Aging System for Prognostics of Power Semiconductor Devices

    NASA Technical Reports Server (NTRS)

    Celaya, Jose R.; Vashchenko, Vladislav; Wysocki, Philip; Saha, Sankalita

    2010-01-01

    Prognostics is an engineering discipline that focuses on estimation of the health state of a component and the prediction of its remaining useful life (RUL) before failure. Health state estimation is based on actual conditions and it is fundamental for the prediction of RUL under anticipated future usage. Failure of electronic devices is of great concern as future aircraft will see an increase of electronics to drive and control safety-critical equipment throughout the aircraft. Therefore, development of prognostics solutions for electronics is of key importance. This paper presents an accelerated aging system for gate-controlled power transistors. This system allows for the understanding of the effects of failure mechanisms, and the identification of leading indicators of failure which are essential in the development of physics-based degradation models and RUL prediction. In particular, this system isolates electrical overstress from thermal overstress. Also, this system allows for a precise control of internal temperatures, enabling the exploration of intrinsic failure mechanisms not related to the device packaging. By controlling the temperature within safe operation levels of the device, accelerated aging is induced by electrical overstress only, avoiding the generation of thermal cycles. The temperature is controlled by active thermal-electric units. Several electrical and thermal signals are measured in-situ and recorded for further analysis in the identification of leading indicators of failures. This system, therefore, provides a unique capability in the exploration of different failure mechanisms and the identification of precursors of failure that can be used to provide a health management solution for electronic devices.

  11. Correlating outdoor exposure with accelerated aging tests for aluminum solar reflectors

    NASA Astrophysics Data System (ADS)

    Wette, Johannes; Sutter, Florian; Fernández-García, Aránzazu

    2016-05-01

    Guaranteeing the durability of concentrated solar power (CSP) components is crucial for the success of the technology. The reflectors of the solar field are a key component of CSP plants, requiring reliable methods for service lifetime prediction. So far, no proven correlations exist to relate accelerated aging test results in climate chambers with relevant CSP exposure sites. In this work, correlations have been derived for selected testing conditions that excite the same degradation mechanisms as for outdoor exposure. Those testing conditions have been identified by performing an extensive microscopic comparison of the appearing degradation mechanisms on reference samples that have been weathered outdoors with samples that underwent a high variety of accelerated aging experiments. The herein developed methodology is derived for aluminum reflectors and future work will study its applicability to silvered-glass mirrors.

  12. Space Acceleration Measurement System (SAMS)/Orbital Acceleration Research Experiment (OARE)

    NASA Technical Reports Server (NTRS)

    Hakimzadeh, Roshanak

    1998-01-01

    The Life and Microgravity Spacelab (LMS) payload flew on the Orbiter Columbia on mission STS-78 from June 20th to July 7th, 1996. The LMS payload on STS-78 was dedicated to life sciences and microgravity experiments. Two accelerometer systems managed by the NASA Lewis Research Center (LERC) flew to support these experiments, namely the Orbital Acceleration Research Experiment (OARE) and the Space Acceleration Measurements System (SAMS). In addition, the Microgravity Measurement Assembly (NOAA), managed by the European Space Research and Technology Center (ESA/ESTEC), and sponsored by NASA, collected acceleration data in support of the experiments on-board the LMS mission. OARE downlinked real-time quasi-steady acceleration data, which was provided to the investigators. The SAMS recorded higher frequency data on-board for post-mission analysis. The MMA downlinked real-time quasi-steady as well as higher frequency acceleration data, which was provided to the investigators. The Principal Investigator Microgravity Services (PIMS) project at NASA LERC supports principal investigators of microgravity experiments as they evaluate the effects of varying acceleration levels on their experiments. A summary report was prepared by PIMS to furnish interested experiment investigators with a guide to evaluate the acceleration environment during STS-78, and as a means of identifying areas which require further study. The summary report provides an overview of the STS-78 mission, describes the accelerometer systems flown on this mission, discusses some specific analyses of the accelerometer data in relation to the various activities which occurred during the mission, and presents plots resulting from these analyses as a snapshot of the environment during the mission. Numerous activities occurred during the STS-78 mission that are of interest to the low-gravity community. Specific activities of interest during this mission were crew exercise, radiator deployment, Vernier Reaction

  13. Micro-Bubble Experiments at the Van de Graaff Accelerator

    SciTech Connect

    Sun, Z. J.; Wardle, Kent E.; Quigley, K. J.; Gromov, Roman; Youker, A. J.; Makarashvili, Vakhtang; Bailey, James; Stepinski, D. C.; Chemerisov, S. D.; Vandegrift, G. F.

    2015-02-01

    In order to test and verify the experimental designs at the linear accelerator (LINAC), several micro-scale bubble ("micro-bubble") experiments were conducted with the 3-MeV Van de Graaff (VDG) electron accelerator. The experimental setups included a square quartz tube, sodium bisulfate solution with different concentrations, cooling coils, gas chromatography (GC) system, raster magnets, and two high-resolution cameras that were controlled by a LabVIEW program. Different beam currents were applied in the VDG irradiation. Bubble generation (radiolysis), thermal expansion, thermal convection, and radiation damage were observed in the experiments. Photographs, videos, and gas formation (O2 + H2) data were collected. The micro-bubble experiments at VDG indicate that the design of the full-scale bubble experiments at the LINAC is reasonable.

  14. Constant Acceleration: Experiments with a Fan-Driven Dynamics Cart.

    ERIC Educational Resources Information Center

    Morse, Robert A.

    1993-01-01

    Describes the rebuilding of a Project Physics fan cart on a PASCO dynamics cart chassis for achieving greatly reduced frictional forces. Suggests four experiments for the rebuilt cart: (1) acceleration on a level track, (2) initial negative velocity, (3) different masses and different forces, and (4) inclines. (MVL)

  15. Nuclear effects in atmospheric and accelerator neutrino experiments

    SciTech Connect

    Chauhan, S.; Athar, M. Sajjad; Singh, S. K.

    2010-11-24

    We have studied the nuclear medium effects in the neutrino (antineutrino) induced interactions in nuclei at intermediate energy region. We have applied this study to calculate the event rates for atmospheric and accelerator neutrino experiments. The study of the nuclear effects has been done for the quasielastic lepton production and the charged current incoherent and coherent pion production processes.

  16. The Student Course Experience among Online, Accelerated, and Traditional Courses

    ERIC Educational Resources Information Center

    Bielitz, Colleen L.

    2016-01-01

    The demand by the public for a wider variety of course formats has led to complexity in determining a course's optimal delivery format as many faculty members still believe that online and accelerated courses do not offer students an equivalent experience to traditional face to face instruction. The purpose of this quantitative, comparative study…

  17. Volatile profile of Madeira wines submitted to traditional accelerated ageing.

    PubMed

    Pereira, Vanda; Cacho, Juan; Marques, José C

    2014-11-01

    The evolution of monovarietal fortified Madeira wines forced-aged by traditional thermal processing (estufagem) were studied in terms of volatiles. SPE extracts were analysed by GC-MS before and after heating at 45 °C for 3 months (standard) and at 70 °C for 1 month (overheating). One hundred and ninety volatile compounds were identified, 53 of which were only encountered in baked wines. Most chemical families increased after standard heating, especially furans and esters, up to 61 and 3-fold, respectively. On the contrary, alcohols, acetates and fatty acids decreased after heating. Varietal aromas, such as Malvasia's monoterpenic alcohols were not detected after baking. The accelerated ageing favoured the development of some volatiles previously reported as typical aromas of finest Madeira wines, particularly phenylacetaldeyde, β-damascenone and 5-ethoxymethylfurfural. Additionally, ethyl butyrate, ethyl 2-methylbutyrate, ethyl caproate, ethyl isovalerate, guaiacol, 5-hydroxymethylfurfural and γ-decalactone were also found as potential contributors to the global aroma of baked wines.

  18. Accelerator/Experiment Operations - FY 2001 Through FY 2003

    SciTech Connect

    Jeffrey A. Appel et al.

    2004-02-05

    This Technical Memorandum (TM) summarizes the accelerator and experiment operations for the period FY 2001 through FY 2003. The plan is to have an annual TM to gather such information in one place. In this case, the information concerns the startup of Run II at the Tevatron Collider and the beginning of the MiniBooNE neutrino experiment. While the focus is on the FY 2003 efforts, this document includes summaries of the earlier years where available for completeness.

  19. Magnetohydrodynamic Particle Acceleration Processes: SSX Experiments, Theory, and Astrophysical Applications

    SciTech Connect

    Brown, Michael R.

    2006-11-16

    Project Title: Magnetohydrodynamic Particle Acceleration Processes: SSX Experiments, Theory, and Astrophysical Applications PI: Michael R. Brown, Swarthmore College The purpose of the project was to provide theoretical and modeling support to the Swarthmore Spheromak Experiment (SSX). Accordingly, the theoretical effort was tightly integrated into the SSX experimental effort. During the grant period, Michael Brown and his experimental collaborators at Swarthmore, with assistance from W. Matthaeus as appropriate, made substantial progress in understanding the physics SSX plasmas.

  20. First results of the plasma wakefield acceleration experiment at PITZ

    NASA Astrophysics Data System (ADS)

    Lishilin, O.; Gross, M.; Brinkmann, R.; Engel, J.; Grüner, F.; Koss, G.; Krasilnikov, M.; Martinez de la Ossa, A.; Mehrling, T.; Osterhoff, J.; Pathak, G.; Philipp, S.; Renier, Y.; Richter, D.; Schroeder, C.; Schütze, R.; Stephan, F.

    2016-09-01

    The self-modulation instability of long particle beams was proposed as a new mechanism to produce driver beams for proton driven plasma wakefield acceleration (PWFA). The PWFA experiment at the Photo Injector Test facility at DESY, Zeuthen site (PITZ) was launched to experimentally demonstrate and study the self-modulation of long electron beams in plasma. Key aspects for the experiment are the very flexible photocathode laser system, a plasma cell and well-developed beam diagnostics. In this contribution we report about the plasma cell design, preparatory experiments and the results of the first PWFA experiment at PITZ.

  1. Comparative Study on Accelerated Thermal Ageing of Vegetable Insulating Oil-paperboard and Mineral Oil-paperboard

    NASA Astrophysics Data System (ADS)

    Zhou, Zhu-Jun; Hu, Ting; Cheng, Lin; Tian, Kai; Yang, Jun; Wang, Xuan; Fang, Fu-Xin; Kong, Hai-Yang; Qian, Hang

    2016-05-01

    To comparatively study the insulation ageing life of vegetable insulating oil-paperboard and mineral oil-paperboard, we conducted accelerated thermal ageing experiments at 170°C. Then according to the temperature rise of vegetable insulating oil transformer, we conducted accelerated thermal ageing experiments at 150°C for vegetable insulating oil-paperboard and at 140°C for mineral oil-paperboard. The appearance, polymerization degree, and SEM microstructure of the paperboard after different ageing experiments were comparative analyzed. The results show that after the oil-paperboard system is accelerated ageing for 1 000 h at 170°C, that is equivalent to 20 years natural ageing, the structure of paperboard in vegetable insulating oil is damaged severely, which indicates that the lifetime of transformer are in the late stage; while the structure of paperboard in mineral oil maintain complete, and the polymerization degree is still above 500, which indicate that the lifetime of transformer are in the middle stage. The accelerated ageing rate of the vegetable insulating oil-paperboard system at 150°C is slower than that of the mineral oil-paperboard system, which indicates that the lifetime of the vegetable insulating oil-paperboard is longer than that of the mineral oil-paperboard.

  2. Proposition of an Accelerated Ageing Method for Natural Fibre/Polylactic Acid Composite

    NASA Astrophysics Data System (ADS)

    Zandvliet, Clio; Bandyopadhyay, N. R.; Ray, Dipa

    2015-10-01

    Natural fibre composite based on polylactic acid (PLA) composite is of special interest because it is entirely from renewable resources and biodegradable. Some samples of jute/PLA composite and PLA alone made 6 years ago and kept in tropical climate on a shelf shows too fast ageing degradation. In this work, an accelerated ageing method for natural fibres/PLA composite is proposed and tested. Experiment was carried out with jute and flax fibre/PLA composite. The method was compared with the standard ISO 1037-06a. The residual flexural strength after ageing test was compared with the one of common wood-based panels and of real aged samples prepared 6 years ago.

  3. Experiment to Detect Accelerating Modes in a Photonic Bandgap Fiber

    SciTech Connect

    England, R.J.; Colby, E.R.; Ischebeck, R.; McGuinness, C.M.; Noble, R.; Plettner, T.; Sears, C.M.S.; Siemann, R.H.; Spencer, J.E.; Walz, D.; /SLAC

    2011-11-21

    An experimental effort is currently underway at the E-163 test beamline at Stanford Linear Accelerator Center to use a hollow-core photonic bandgap (PBG) fiber as a high-gradient laser-based accelerating structure for electron bunches. For the initial stage of this experiment, a 50pC, 60 MeV electron beam will be coupled into the fiber core and the excited modes will be detected using a spectrograph to resolve their frequency signatures in the wakefield radiation generated by the beam. They will describe the experimental plan and recent simulation studies of candidate fibers.

  4. Experiment to Detect Accelerating Modes in a Photonic Bandgap Fiber

    SciTech Connect

    England, R. J.; Colby, E. R.; McGuinness, C. M.; Noble, R.; Plettner, T.; Siemann, R. H.; Spencer, J. E.; Walz, D.; Ischebeck, R.; Sears, C. M. S.

    2009-01-22

    An experimental effort is currently underway at the E-163 test beamline at Stanford Linear Accelerator Center to use a hollow-core photonic bandgap (PBG) fiber as a high-gradient laser-based accelerating structure for electron bunches. For the initial stage of this experiment, a 50 pC, 60 MeV electron beam will be coupled into the fiber core and the excited modes will be detected using a spectrograph to resolve their frequency signatures in the wakefield radiation generated by the beam. We will describe the experimental plan and recent simulation studies of candidate fibers.

  5. Experimental test accelerator: description and results of initial experiments

    SciTech Connect

    Fessenden, T.; Birx, D.; Briggs, R.

    1980-06-02

    The ETA is a high current (10,000 Amp) linear induction accelerator that produces short (30 ns) pulses of electrons at 5 MeV twice per second or in bursts of 5 pulses separated by as little as one millisecond. At this time the machine has operated at 65% of its design current and 90% of the design voltage. This report contains a description of the accelerator and its diagnostics; the results of the initial year of operation; a comparison of design codes with experiments on beam transport; and a discussion of some of the special problems and their status.

  6. Effects of Accelerated Aging on Fiber Damage Thresholds

    SciTech Connect

    Setchell, R.E.

    1999-02-15

    internal defects. Damage characteristics obtained from fibers subjected to each of these aging environments were compared to results from fresh fibers tested under identical conditions. A surprising result was that internal damage was not observed in any of the tested fibers. Only breakdown at the fiber entrance face and catastrophic damage at both end faces were observed. Fiber end faces were not sealed during the accelerated aging environments, and thresholds at these faces were significantly lower in the aged fibers. However, most fibers transmitted relatively high pulse energies before damaging, and a large fraction never damaged before we reached the limits of our test laser. The absence of any observable affect on internal damage thresholds is encouraging, but the current results do not rule out the possibility that some other approach to accelerated aging could reveal a growth mechanism for internal defects.

  7. Acceleration results from the microwave inverse FEL experiment

    NASA Astrophysics Data System (ADS)

    Yoder, R. B.; Marshall, T. C.; Hirshfield, J. L.

    2001-05-01

    An inverse free-electron-laser accelerator has been developed, built, and operated in the microwave regime. Development of this device has been described at previous Workshops; the accelerator is driven by RF power at 2.8 GHz propagating in a smooth-walled circular waveguide surrounded by a pulsed bifilar helical undulator with tapered pitch, while an array of solenoid coils provides an axial guide magnetic field. In low-power experiments, injected electron beams at energies between 5 and 6 MeV have gained up to 0.35 MeV with minimal energy spread, and the phase sensitivity of the IFEL mechanism has been clearly demonstrated for the first time. Agreement with simulation is very good for accelerating phases, though less exact otherwise. Scaling the device to high power and high frequency is discussed.

  8. Sod2 haploinsufficiency does not accelerate aging of telomere dysfunctional mice.

    PubMed

    Guachalla, Luis Miguel; Ju, Zhenyu; Koziel, Rafal; von Figura, Guido; Song, Zhangfa; Fusser, Markus; Epe, Bernd; Jansen-Durr, Pidder; Rudolph, K Lenhard

    2009-03-05

    Telomere shortening represents a causal factor of cellular senescence. At the same time, several lines of evidence indicate a pivotal role of oxidative DNA damage for the aging process in vivo. A causal connection between the two observations was suggested by experiments showing accelerated telomere shorting under conditions of oxidative stress in cultured cells, but has never been studied in vivo. We therefore have analysed whether an increase in mitochondrial derived oxidative stress in response to heterozygous deletion of superoxide dismutase (Sod2(+/-)) would exacerbate aging phenotypes in telomere dysfunctional (mTerc(-/-)) mice. Heterozygous deletion of Sod2 resulted in reduced SOD2 protein levels and increased oxidative stress in aging telomere dysfunctional mice, but this did not lead to an increase in basal levels of oxidative nuclear DNA damage, an accumulation of nuclear DNA breaks, or an increased rate of telomere shortening in the mice. Moreover, heterozygous deletion of Sod2 did not accelerate the depletion of stem cells and the impairment in organ maintenance in aging mTerc(-/-) mice. In agreement with these observations, Sod2 haploinsufficiency did not lead to a further reduction in lifespan of mTerc(-/-) mice. Together, these results indicate that a decrease in SOD2-dependent antioxidant defence does not exacerbate aging in the context of telomere dysfunction.

  9. Accelerating Vaccine Formulation Development Using Design of Experiment Stability Studies.

    PubMed

    Ahl, Patrick L; Mensch, Christopher; Hu, Binghua; Pixley, Heidi; Zhang, Lan; Dieter, Lance; Russell, Ryann; Smith, William J; Przysiecki, Craig; Kosinski, Mike; Blue, Jeffrey T

    2016-10-01

    Vaccine drug product thermal stability often depends on formulation input factors and how they interact. Scientific understanding and professional experience typically allows vaccine formulators to accurately predict the thermal stability output based on formulation input factors such as pH, ionic strength, and excipients. Thermal stability predictions, however, are not enough for regulators. Stability claims must be supported by experimental data. The Quality by Design approach of Design of Experiment (DoE) is well suited to describe formulation outputs such as thermal stability in terms of formulation input factors. A DoE approach particularly at elevated temperatures that induce accelerated degradation can provide empirical understanding of how vaccine formulation input factors and interactions affect vaccine stability output performance. This is possible even when clear scientific understanding of particular formulation stability mechanisms are lacking. A DoE approach was used in an accelerated 37(°)C stability study of an aluminum adjuvant Neisseria meningitidis serogroup B vaccine. Formulation stability differences were identified after only 15 days into the study. We believe this study demonstrates the power of combining DoE methodology with accelerated stress stability studies to accelerate and improve vaccine formulation development programs particularly during the preformulation stage. PMID:27522919

  10. Absolute acceleration measurements on STS-50 from the Orbital Acceleration Research Experiment (OARE)

    NASA Technical Reports Server (NTRS)

    Blanchard, Robert C.; Nicholson, John Y.; Ritter, James R.

    1994-01-01

    Orbital Acceleration Research Experiment (OARE) data on Space Transportation System (STS)-50 have been examined in detail during a 2-day time period. Absolute acceleration levels have been derived at the OARE location, the orbiter center-of-gravity, and at the STS-50 spacelab Crystal Growth Facility. During the interval, the tri-axial OARE raw telemetered acceleration measurements have been filtered using a sliding trimmed mean filter in order to remove large acceleration spikes (e.g., thrusters) and reduce the noise. Twelve OARE measured biases in each acceleration channel during the 2-day interval have been analyzed and applied to the filtered data. Similarly, the in situ measured x-axis scale factors in the sensor's most sensitive range were also analyzed and applied to the data. Due to equipment problem(s) on this flight, both y- and z-axis sensitive range scale factors were determined in a separate process using orbiter maneuvers and subsequently applied to the data. All known significant low-frequency corrections at the OARE location (i.e., both vertical and horizontal gravity-gradient, and rotational effects) were removed from the filtered data in order to produce the acceleration components at the orbiter center-of-gravity, which are the aerodynamic signals along each body axis. Results indicate that there is a force being applied to the Orbiter in addition to the aerodynamic forces. The OARE instrument and all known gravitational and electromagnetic forces have been reexamined, but none produces the observed effect. Thus, it is tentatively concluded that the orbiter is creating the environment observed. At least part of this force is thought to be due to the Flash Evaporator System.

  11. The Awful Truth About Zero-Gravity: Space Acceleration Measurement System; Orbital Acceleration Research Experiment

    NASA Technical Reports Server (NTRS)

    2002-01-01

    Earth's gravity holds the Shuttle in orbit, as it does satellites and the Moon. The apparent weightlessness experienced by astronauts and experiments on the Shuttle is a balancing act, the result of free-fall, or continuously falling around Earth. An easy way to visualize what is happening is with a thought experiment that Sir Isaac Newton did in 1686. Newton envisioned a mountain extending above Earth's atmosphere so that friction with the air would be eliminated. He imagined a cannon atop the mountain and aimed parallel to the ground. Firing the cannon propels the cannonball forward. At the same time, Earth's gravity pulls the cannonball down to the surface and eventual impact. Newton visualized using enough powder to just balance gravity so the cannonball would circle the Earth. Like the cannonball, objects orbiting Earth are in continuous free-fall, and it appears that gravity has been eliminated. Yet, that appearance is deceiving. Activities aboard the Shuttle generate a range of accelerations that have effects similar to those of gravity. The crew works and exercises. The main data relay antenna quivers 17 times per second to prevent 'stiction,' where parts stick then release with a jerk. Cooling pumps, air fans, and other systems add vibration. And traces of Earth's atmosphere, even 200 miles up, drag on the Shuttle. While imperceptible to us, these vibrations can have a profound impact on the commercial research and scientific experiments aboard the Shuttle. Measuring these forces is necessary so that researchers and scientists can see what may have affected their experiments when analyzing data. On STS-107 this service is provided by the Space Acceleration Measurement System for Free Flyers (SAMS-FF) and the Orbital Acceleration Research Experiment (OARE). Precision data from these two instruments will help scientists analyze data from their experiments and eliminate outside influences from the phenomena they are studying during the mission.

  12. Ultra-High Gradient Dielectric Wakefield Accelerator Experiments

    SciTech Connect

    Thompson, M C; Badakov, H; Rosenzweig, J B; Travish, G; Hogan, M; Ischebeck, R; Kirby, N; Siemann, R; Walz, D; Muggli, P; Scott, A; Yoder, R

    2006-08-04

    Ultra-high gradient dielectric wakefield accelerators are a potential option for a linear collider afterburner since they are immune to the ion collapse and electron/positron asymmetry problems implicit in a plasma based afterburner. The first phase of an experiment to study the performance of dielectric Cerenkov wakefield accelerating structures at extremely high gradients in the GV/m range has been completed. The experiment took advantage of the unique SLAC FFTB electron beam and its ultra-short pulse lengths and high currents (e.g., {sigma}{sub z} = 20 {micro}m at Q = 3 nC). The FFTB electron beam was successfully focused down and sent through short lengths of fused silica capillary tubing (ID = 200 {micro}m/OD = 325 {micro}m). The pulse length of the electron beam was varied to produce a range of electric fields between 2 and 20 GV/m at the inner surface of the dielectric tubes. We observed a sharp increase in optical emissions from the capillaries in the middle part of this surface field range which we believe indicates the transition between sustainable field levels and breakdown. If this initial interpretation is correct, the surfaced fields that were sustained equate to on axis accelerating field of several GV/m. In future experiments being developed for the SLAC SABER and BNL ATF we plan to use the coherent Cerenkov radiation emitted from the capillary tube as a field strength diagnostic and demonstrate GV/m range particle energy gain.

  13. Ultra-High Gradient Dielectric Wakefield Accelerator Experiments

    SciTech Connect

    Thompson, M.C.; Badakov, H.; Rosenzweig, J.B.; Travish, G.; Hogan, M.; Ischebeck, R.; Kirby, N.; Siemann, R.; Walz, D.; Muggli, P.; Scott, A.; Yoder, R.; /LLNL, Livermore /UCLA /SLAC /Southern California U. /UC, Santa Barbara /Manhattan Coll., Riverdale

    2007-03-27

    Ultra-high gradient dielectric wakefield accelerators are a potential option for a linear collider afterburner since they are immune to the ion collapse and electron/positron asymmetry problems implicit in a plasma based afterburner. The first phase of an experiment to study the performance of dielectric Cerenkov wakefield accelerating structures at extremely high gradients in the GV/m range has been completed. The experiment took advantage of the unique SLAC FFTB electron beam and its ultra-short pulse lengths and high currents (e.g., {sigma}{sub z} = 20 {micro}m at Q = 3 nC). The FFTB electron beam was successfully focused down and sent through short lengths of fused silica capillary tubing (ID = 200 {micro}m/OD = 325 {micro}m). The pulse length of the electron beam was varied to produce a range of electric fields between 2 and 20 GV/m at the inner surface of the dielectric tubes. We observed a sharp increase in optical emissions from the capillaries in the middle part of this surface field range which we believe indicates the transition between sustainable field levels and breakdown. If this initial interpretation is correct, the surfaced fields that were sustained equate to on axis accelerating field of several GV/m. In future experiments being developed for the SLAC SABER and BNL ATF we plan to use the coherent Cerenkov radiation emitted from the capillary tube as a field strength diagnostic and demonstrate GV/m range particle energy gain.

  14. Accelerated long-term forgetting in aging and intra-sleep awakenings

    PubMed Central

    Mary, Alison; Schreiner, Svenia; Peigneux, Philippe

    2013-01-01

    The architecture of sleep and the functional neuroanatomical networks subtending memory consolidation processes are both modified with aging, possibly leading to accelerated forgetting in long-term memory. We investigated associative learning and declarative memory consolidation processes in 16 young (18–30 years) and 16 older (65–75 years) healthy adults. Performance was tested using a cued recall procedure at the end of learning (immediate recall), and 30 min and 7 days later. A delayed recognition test was also administered on day 7. Daily sleep diaries were completed during the entire experiment. Results revealed a similar percentage of correct responses at immediate and 30-min recall in young and older participants. However, recall was significantly decreased 7 days later, with an increased forgetting in older participants. Additionally, intra-sleep awakenings were more frequent in older participants than young adults during the seven nights, and were negatively correlated with delayed recall performance on day 7 in the older group. Altogether, our results suggest a decline in verbal declarative memory consolidation processes with aging, eventually leading to accelerated long-term forgetting indicating that increased sleep fragmentation due to more frequent intra-sleep awakenings in older participants contribute to the reported age-related decline in long-term memory retrieval. Our results highlight the sensitivity of long-term forgetting measures to evidence consolidation deficits in healthy aging. PMID:24137151

  15. Cryogenic supply for accelerators and experiments at FAIR

    SciTech Connect

    Kauschke, M.; Xiang, Y.; Schroeder, C. H.; Streicher, B.; Kollmus, H.

    2014-01-29

    In the coming years the new international accelerator facility FAIR (Facility for Antiproton and Ion Research), one of the largest research projects worldwide, will be built at GSI. In the final construction FAIR consists of synchrotrons and storage rings with up to 1,100 meters in circumference, two linear accelerators and about 3.5 kilometers beam transfer lines. The existing GSI accelerators serve as pre-accelerators. Partly the new machines will consist of superconducting magnets and therefore require a reliable supply with liquid helium. As the requirements for the magnets is depending on the machine and have a high variety, the cooling system is different for each machine; two phase cooling, forced flow cooling and bath cooling respectively. In addition the cold mass of the individual magnets varies between less than 1t up to 80t and some magnets will cause a dynamic heat load due to ramping that is higher than the static loads. The full cryogenic system will be operated above atmospheric pressure. The refrigeration and liquefaction power will be provided by two main cryogenic plants of 8 and 25 kW at 4K and two smaller plants next to the experiments.

  16. Dielectric Wakefield Accelerator Experiments at the SABER Facility

    SciTech Connect

    Kanareykin, A.; Thompson, M.C.; Berry, M.K.; Blumenfeld, I.; Decker, F.J.; Hogan, M.J.; Ischebeck, R.; Iverson, R.H.; Kirby, N.A.; Siemann, Robert H.; Walz, D.R.; Badakov, H.; Cook, A.M.; Rosenzweig, J.B.; Tikhoplav, R.; Travish, G.; Muggli, P.; /Southern California U.

    2008-01-28

    Electron bunches with the unparalleled combination of high charge, low emittances, and short time duration, as first produced at the SLAC Final Focus Test Beam (FFTB), are foreseen to be produced at the SABER facility. These types of bunches have enabled wakefield driven accelerating schemes of multi-GV/m in plasmas. In the context of the Dielectric Wakefield Accelerators (DWA) such beams, having rms bunch length as short as 20 um, have been used to drive 100 um and 200 um ID hollow tubes above 20 GV/m surface fields. These FFTB tests enabled the measurement of a breakdown threshold in fused silica (with full data analysis still ongoing) [1]. With the construction and commissioning of the SABER facility at SLAC, new experiments would be made possible to test further aspects of DWAs including materials, tube geometrical variations, direct measurements of the Cerenkov fields, and proof of acceleration in tubes >10 cm in length. This collaboration will investigate breakdown thresholds and accelerating fields in new materials including CVD diamond. Here we describe the experimental plans, beam parameters, simulations, and progress to date as well as future prospects for machines based of DWA structures.

  17. Color stability of repaired composite submitted to accelerated artificial aging.

    PubMed

    Souza, Ana Beatriz Silva; Silame, Francisca Daniele Jardilino; Alandia-Roman, Carla Cecilia; Cruvinel, Diogo Rodrigues; Garcia, Lucas da Fonseca Roberti; Pires-de-Souza, Fernanda de Carvalho Panzeri

    2012-01-01

    The aim of this study was to evaluate the color stability (ΔE) of nanoparticulate composite, with consideration for the type of surface treatment performed before repair. A Teflon matrix was used to fabricate 50 test specimens from composite. After initial color readout, the specimens were submitted to 100 hours of accelerated artificial aging (AAA). The samples were divided into five groups (n = 10), according to the surface treatment performed: sandblasting with aluminum oxide powder, phosphoric acid, and an adhesive system (Group 1); sandblasting with aluminum oxide powder, phosphoric acid, and a flowable composite (Group 2); abrasion with a diamond bur, phosphoric acid, and an adhesive system (Group 3); abrasion with a diamond bur, phosphoric acid, and a nanoparticulate composite (Group 4); and a control group (Group 5). After repair, a new color readout was taken, the test specimens were submitted to a new AAA cycle (300 hours), and the final color readout was taken. Comparison of the ΔE means (one-way ANOVA and Tukey tests, p < 0.05) demonstrated no statistically significant differences among the groups (p > 0.05) after 100 hours of AAA. After repair, Group 1 (4.61 ± 2.03) presented the highest color alteration with a statistically significant difference compared with the other groups (p < 0.05). After 300 hours, Group 4 specimens (13.84 ± 0.71) presented the lowest color alteration in comparison with the other groups, with a statistically significant difference (p < 0.05). It was concluded that the repair performed in Group 4 provided greater esthetic recovery, made possible by the regression in the ΔE values of the restorations after repair, and less color alteration of the restorations over the course of time. PMID:23032241

  18. Magnetic acceleration of aluminum foils for shock wave experiments

    NASA Astrophysics Data System (ADS)

    Neff, Stephan; Martinez, David; Plechaty, Christopher; Stein, Sandra; Presura, Radu

    2010-06-01

    Scaled experiments studying the interaction of shock waves with inhomogeneous background media are essential for understanding many astrophysical phenomena, since they can be used to test analytical theories and simulation codes. We are currently developing such experiments at the Nevada Terawatt Facility. We are using a pulsed power generator (1 MA peak current) to accelerate thin aluminum flyer plates. By impacting these foils on low-density foam targets, we will be able to carry out scaled experiments. We have demonstrated velocities of up to 8 km/s for 50 μm thick aluminum flyers, and are planning to further increase the flyer velocities. We have also carried out first impact tests with transparent polycarbonate targets. Several improvements for our setup are currently in planning, and these improvements will enable us to design scaled experiments for our facility.

  19. Structure Loaded Vacuum Laser-Driven Particle Acceleration Experiments at SLAC

    SciTech Connect

    Plettner, T.; Byer, R.L.; Colby, E.R.; Cowan, B.M.; Ischebeck, R.; McGuinness, C.; Lincoln, M.R.; Sears, C.M.; Siemann, R.H.; Spencer, J.E.; /SLAC /Stanford U., Phys. Dept.

    2007-04-09

    We present an overview of the future laser-driven particle acceleration experiments. These will be carried out at the E163 facility at SLAC. Our objectives include a reconfirmation of the proof-of-principle experiment, a staged buncher laser-accelerator experiment, and longer-term future experiments that employ dielectric laser-accelerator microstructures.

  20. Hypervelocity macroparticle accelerator experiments at CEM-UT

    SciTech Connect

    Weeks, D.A.; Weldon, W.F.; Zowarka, R.C. Jr. . Center for Electromechanics)

    1991-01-01

    This paper reports on several railgun experiments designed to accelerate projectile masses of 2 to 5 g to velocities greater than 6 km/s that were performed at the Center for Electromechanics at The University of Texas at Austin (CEM-UT). Two parallel rail-type accelerators with 12.7 mm square bores were used for the experiments. One gun is 2-m long, has molybdenum rails, alumina ceramic insulators, and the other gun is 1-m long, has molybdenum rails, and granite insulators. The greatest velocity achieved to date during the experiments was 5.1 kn/s. During the test program, the following ideas to enhance launcher performance were tested: stiff-gun structures to reduce plasma leakage and rail movement; refractory bore materials to reduce ablation and frictional losses; and prefilling the gun bore with gases which will eliminate precursor arcs. After three experiments utilizing the 2 m long launcher, with peak current ranging from 660 to 780 kA (bore pressures ranging from 62.6 to 87.5 ksi), a gun barrel comprised of 96% pure alumina ceramic insulators and 99.9% pure molybdenum rails (which is hydraulically contained and preloaded) has survived with minimal damage and no degradation of seals.

  1. Impulse noise exposure in early adulthood accelerates age-related hearing loss.

    PubMed

    Xiong, Min; Yang, Chuanhong; Lai, Huangwen; Wang, Jian

    2014-06-01

    The aim of this study was to investigate the influence of impulse noise on age-related hearing loss. The study consisted of two groups. Each group contained 109 men. Group I comprised veterans with normal hearing at the end of 1979 sino-vietnamese war. All these veterans were randomly selected from Guangzhou Military Command. Group II were men with no military experience randomly chosen from the health examination center of Guangzhou General Hospital of Guangzhou Military Command. Pure-tone thresholds of these two groups were measured and compared. The pure-tone thresholds of Group I were poorer than those of Group II at the frequencies of 4, 6 and 8 kHz. Thus, impulse noise accelerates age-related hearing loss.

  2. Analysis of Capillary Guided Laser Plasma Accelerator Experiments at LBNL

    SciTech Connect

    Nakamura, K.; Esarey, E.; Leemans, W. P.; Gonsalves, A. J.; Panasenko, D.; Toth, Cs.; Geddes, C. G. R.; Schroeder, C. B.; Lin, C.

    2009-01-22

    Laser wakefield acceleration experiments were carried out by using a hydrogen-filled capillary discharge waveguide. For a 15 mm long, 200 {mu}m diameter capillary, quasi-monoenergetic e-beams up to 300 MeV were observed. By de-tuning discharge delay from optimum guiding performance, self-trapping was found to be stabilized. For a 33 mm long, 300 {mu}m capillary, a parameter regime with high energy electron beams, up to 1 GeV, was found. In this regime, the electron beam peak energy was correlated with the amount of trapped electrons.

  3. Analysis of Capillary Guided Laser Plasma Accelerator Experiments at LBNL

    SciTech Connect

    Advanced Light Source; Nakamura, Kei; Gonsalves, Anthony; Panasenko, Dmitriy; Lin, Chen; Toth, Csaba; Geddes, Cameron; Schroeder, Carl; Esarey, Eric; Leemans, Wim

    2008-09-29

    Laser wakefield acceleration experiments were carried out by using a hydrogen-filledcapillary discharge waveguide. For a 15 mm long, 200 mu m diameter capillary, quasi-monoenergetic e-beams up to 300 MeV were observed. By de-tuning discharge delay from optimum guiding performance, self-trapping was found to be stabilized. For a 33 mm long, 300 mu m capillary, a parameter regime with high energy electron beams, up to 1 GeV, was found. In this regime, the electron beam peak energy was correlated with the amount of trapped electrons.

  4. High Temperature μSR Experiments for Accelerator Developments

    NASA Astrophysics Data System (ADS)

    Ohmori, Chihiro; Koda, Akihiro; Miyake, Yasuhiro; Nishiyama, Kusuo; Shimomura, Koichiro; Schnase, Alexander; Ezura, Eiji; Hara, Keigo; Hasegawa, Katsushi; Nomura, Masahiro; Shimada, Taihei; Takata, Koji; Tamura, Fumihiko; Toda, Makoto; Yamamoto, Masanobu; Yoshii, Masahito

    High temperature μSR is a powerful technique to study magnetic materials. In J-PARC accelerator synchrotrons, the Rapid Cycling Synchrotron (RCS) and Main Ring (MR), a unique magnetic alloy-loaded cavity is used for the beam acceleration and much higher field gradient has been achieved. Such high field gradient cavities made a compact RCS possible by reducing the length for beam acceleration. Now, further upgrades of the J-PARC, RF cavities with higher RF voltage and less power loss in the magnetic core are needed for the MR. For the improvements of the magnetic property of magnetic alloy core, the high temperature μSR (muon Spin Rotation/Relaxation) was used to investigate the crystallization process of the material. Based on the measurement results, the test production of the large ring cores of a magnetic alloy, FT3L, was tried. The FT3L is the magnetic alloy which has two times better performance than the present one, FT3M. For the FT3L production, the magnetic annealing is needed to control the easy-magnetized axis of the crystalline. After the success of the test production, a mass production was started in the industry to replace all existing cavities in the MR. The first 5-cell FT3L cavity is assembled for the bench test before the installation in the accelerator tunnel. By the new cavities, the total RF voltage of J-PARC MR will be doubled to increase the beam power for neutrino experiment. In future, the cavities will be also used for the RCS to increase the beam power beyond 1 MW.

  5. Characteristics of age-related behavioral changes in senescence-accelerated mouse SAMP8 and SAMP10.

    PubMed

    Miyamoto, M

    1997-01-01

    Senescence-Accelerated Mouse (SAM), a murine model of accelerated senescence, has been established by Takeda et al. (1981). SAM consists of senescence-accelerated-prone mouse (SAMP) and senescence-accelerated-resistant mouse (SAMR), the latter of which shows normal aging characteristics. In 1991 there were eight different substrains in the P-series, which commonly exhibited accelerated aging with a shortened life span (Takeda et al., 1991). Among the P-series, we have found that SAMP8 mice show significant impairments in a variety of learning tasks when compared with SAMR1 mice (Miyamoto et al., 1986). Further studies suggest that SAMP8 exhibits an age-related emotional disorder characterized by reduced anxiety-like behavior (Miyamoto et al., 1992). On the other hand, it has been shown that SAMP10 exhibits brain atrophy and learning impairments in an avoidance task (Shimada et al., 1992, 1993). Here, characteristics of age-related deficits in learning and memory, changes in emotional behavior, and abnormality of circadian rhythms in SAMP8 and SAMP10 mice are described. In the experiments, SAMP8/Ta (SAMP8), SAMP10/(/)Ta (SAMP10) and SAMR1TA (SAMR1) reared under specific pathogen-free conditions at Takeda Chemical Industries were used. PMID:9088911

  6. Subjective Acceleration of Time Experience in Everyday Life across Adulthood

    ERIC Educational Resources Information Center

    John, Dennis; Lang, Frieder R.

    2015-01-01

    Most people believe that time seems to pass more quickly as they age. Building on assumptions of socioemotional selectivity theory, we investigated whether awareness that one's future lifetime is limited is associated with one's experience of time during everyday activities across adulthood in 3 studies. In the first 2 studies (Study 1: N = 608;…

  7. Subpanel on accelerator-based neutrino oscillation experiments

    SciTech Connect

    1995-09-01

    Neutrinos are among nature`s fundamental constituents, and they are also the ones about which we know least. Their role in the universe is widespread, ranging from the radioactive decay of a single atom to the explosions of supernovae and the formation of ordinary matter. Neutrinos might exhibit a striking property that has not yet been observed. Like the back-and-forth swing of a pendulum, neutrinos can oscillate to-and-from among their three types (or flavors) if nature provides certain conditions. These conditions include neutrinos having mass and a property called {open_quotes}mixing.{close_quotes} The phenomenon is referred to as neutrino oscillations. The questions of the origin of neutrino mass and mixing among the neutrino flavors are unsolved problems for which the Standard Model of particle physics holds few clues. It is likely that the next critical step in answering these questions will result from the experimental observation of neutrino oscillations. The High Energy Physics Advisory Panel (HEPAP) Subpanel on Accelerator-Based Neutrino Oscillation Experiments was charged to review the status and discovery potential of ongoing and proposed accelerator experiments on neutrino oscillations, to evaluate the opportunities for the U.S. in this area of physics, and to recommend a cost-effective plan for pursuing this physics, as appropriate. The complete charge is provided in Appendix A. The Subpanel studied these issues over several months and reviewed all the relevant and available information on the subject. In particular, the Subpanel reviewed the two proposed neutrino oscillation programs at Fermi National Accelerator Laboratory (Fermilab) and at Brookhaven National Laboratory (BNL). The conclusions of this review are enumerated in detail in Chapter 7 of this report. The recommendations given in Chapter 7 are also reproduced in this summary.

  8. Hyper-velocity impact experiments with electrostatic dust accelerators

    NASA Astrophysics Data System (ADS)

    Mocker, Anna; Aust, Thomas; Bugiel, Sebastian; Hillier, Jonathan; Hornung, Klaus; Li, Yan-Wei; Strack, Heiko; Ralf, Srama

    2015-06-01

    Hypervelocity impacts (HVI) of micrometer-sized particles play an important role in a variety of fields such as the investigation of matter at extreme pressures and temperatures, shock waves in solid bodies, planetology and cosmic dust. The physical phenomena occurring upon impact are fragmentation and cratering, shock waves, the production of neutral and ionized gas, and light flashes. Advanced analysis techniques promise new insights into short time-scale high-pressure states of matter, requiring the production of high speed projectiles. Electrostatic accelerators act as a source of micrometer and sub-micrometer particles as projectiles for HVI experiments. This paper describes an HVI facility, capable of accelerating particles to over 100 km/s, currently located at the Max Planck Institute for Nuclear Physics in Heidelberg, together with planned improvements. The facility is about to be relocated to the University of Stuttgart. This is an opportunity to enhance the facility to meet the requirements of future experimental campaigns, necessary to better understand the micrometeoroid hypervelocity impact process and develop new in situ dust experiments. We will present the design of the new facility and the planned enhancements, including new diagnostic apparatus.

  9. Acceleration of age-associated methylation patterns in HIV-1-infected adults.

    PubMed

    Rickabaugh, Tammy M; Baxter, Ruth M; Sehl, Mary; Sinsheimer, Janet S; Hultin, Patricia M; Hultin, Lance E; Quach, Austin; Martínez-Maza, Otoniel; Horvath, Steve; Vilain, Eric; Jamieson, Beth D

    2015-01-01

    Patients with treated HIV-1-infection experience earlier occurrence of aging-associated diseases, raising speculation that HIV-1-infection, or antiretroviral treatment, may accelerate aging. We recently described an age-related co-methylation module comprised of hundreds of CpGs; however, it is unknown whether aging and HIV-1-infection exert negative health effects through similar, or disparate, mechanisms. We investigated whether HIV-1-infection would induce age-associated methylation changes. We evaluated DNA methylation levels at >450,000 CpG sites in peripheral blood mononuclear cells (PBMC) of young (20-35) and older (36-56) adults in two separate groups of participants. Each age group for each data set consisted of 12 HIV-1-infected and 12 age-matched HIV-1-uninfected samples for a total of 96 samples. The effects of age and HIV-1 infection on methylation at each CpG revealed a strong correlation of 0.49, p<1 x 10(-200) and 0.47, p<1 x 10(-200). Weighted gene correlation network analysis (WGCNA) identified 17 co-methylation modules; module 3 (ME3) was significantly correlated with age (cor=0.70) and HIV-1 status (cor=0.31). Older HIV-1+ individuals had a greater number of hypermethylated CpGs across ME3 (p=0.015). In a multivariate model, ME3 was significantly associated with age and HIV status (Data set 1: βage=0.007088, p=2.08 x 10(-9); βHIV=0.099574, p=0.0011; Data set 2: βage=0.008762, p=1.27 x 10(-5); βHIV=0.128649, p=0.0001). Using this model, we estimate that HIV-1 infection accelerates age-related methylation by approximately 13.7 years in data set 1 and 14.7 years in data set 2. The genes related to CpGs in ME3 are enriched for polycomb group target genes known to be involved in cell renewal and aging. The overlap between ME3 and an aging methylation module found in solid tissues is also highly significant (Fisher-exact p=5.6 x 10(-6), odds ratio=1.91). These data demonstrate that HIV-1 infection is associated with methylation patterns that are

  10. Can accelerated aqueous aging simulate in vivo oxidation of gamma-sterilized UHMWPE?

    PubMed

    Mazzucco, Daniel C; Dumbleton, John; Kurtz, Steven M

    2006-10-01

    Oxidation of ultrahigh molecular weight polyethylene (UHMWPE) gamma-sterilized arthroplasty components occurs in vivo. Though accelerated in vitro protocols have been developed to test the relative oxidation resistance of various types of UHMWPE, it is desirable to develop an accelerated aging protocol that more closely approximates the in vivo environment. The goal of this study was to investigate the effects of temperature, solute, and oxygen partial pressure in aqueous media on the oxidation of gamma-sterilized UHMWPE, as the basis for the development of improved accelerated aging protocols. The accelerated oxidation behavior of gamma-sterilized GUR 1150 was studied at 60 and 70 degrees C in an open vessel filled with distilled water or PBS in equilibrium with a controlled partial pressure of oxygen. The extent of oxidation was assessed using standardized mechanical and chemical evaluation techniques (small punch and Fourier transform infrared spectroscopy). Accelerated oxidation of UHMWPE was achieved in aqueous environments; however, both clinically relevant and nonrelevant oxidation species (e.g., aldehydes) were observed for long aging times at 60 degrees C, and for all aging times at 70 degrees C. These findings point the way to the development of an accelerated aging protocol. The current data, considered in conjunction with real-time aging studies, suggest that a temperature between body temperature and 60 degrees C may accelerate oxidative degradation without altering the oxidative patterns encountered in vivo.

  11. Accelerated aging of extruded dielectric power cables. Part 1; Control and monitoring methodology

    SciTech Connect

    Walton, M.S.; Smith, J.T. III ); Thue, W.A. )

    1992-04-01

    In accelerated cable life testing of power cables, cable samples are usually subjected to elevated voltages and temperatures in the presence of water in order to promote aging of the insulation and premature failures through the treeing mechanism. Failure to accurately control and monitor these accelerating facts can have adverse effects on test results and can lead to erroneous conclusions. In this paper, a new and improved accelerated cable life test is described. Through the use of programmable logic controllers (PLCs), very precise and consistent control of the accelerated aging process has been achieved. A computer has been utilized to make continuous real-time data acquisition and storage to key operating parameters possible. This precise control of monitoring methodology has permitted the study of the synergistic effects of voltage and temperature on the accelerated aging of full-sized cables in the laboratory.

  12. GPU-Accelerated Molecular Modeling Coming Of Age

    PubMed Central

    Stone, John E.; Hardy, David J.; Ufimtsev, Ivan S.

    2010-01-01

    Graphics processing units (GPUs) have traditionally been used in molecular modeling solely for visualization of molecular structures and animation of trajectories resulting from molecular dynamics simulations. Modern GPUs have evolved into fully programmable, massively parallel co-processors that can now be exploited to accelerate many scientific computations, typically providing about one order of magnitude speedup over CPU code and in special cases providing speedups of two orders of magnitude. This paper surveys the development of molecular modeling algorithms that leverage GPU computing, the advances already made and remaining issues to be resolved, and the continuing evolution of GPU technology that promises to become even more useful to molecular modeling. Hardware acceleration with commodity GPUs is expected to benefit the overall computational biology community by bringing teraflops performance to desktop workstations and in some cases potentially changing what were formerly batch-mode computational jobs into interactive tasks. PMID:20675161

  13. From the Discovery of Radioactivity to the First Accelerator Experiments

    NASA Astrophysics Data System (ADS)

    Walter, Michael

    The chapter reviews the historical phases of cosmic ray research from the very beginning around 1900 until the 1940s when first particle accelerators replaced cosmic particles as source for elementary particle interactions. In opposite to the discovery of X-rays or the ionising α-, β- and γ-rays, it was an arduous path to the definite acceptance of the new radiation. The starting point was the explanation that air becomes conductive by the ionising radiation of radioactive elements in the surroundings. In the following years the penetration power of the radiation was studied with the result, that there seems be a component harder than the known γ-rays. Victor F. Hess did in 1912 the key experiment with a hydrogen balloon. He measured with three detectors an increase of ionisation up to altitudes of 5 300 m and discovered the extraterrestrial penetrating radiation. The next phase is characterised by W. Kolhörster's confirmation in 1914, doubts by R.A. Millikan and others as well as the spectacular re-discovery of cosmic rays by Millikan in 1926. With the invention of new detectors as the cloud chamber and the Geiger-Müller counter and of the coincidence method the properties of cosmic rays could be investigated. One of the striking results was the discovery that cosmic rays are of corpuscular nature. The broad research activities starting end of the 1920s were the begin of a scientific success story, which nobody of the early protagonists might have imagined. In 1932 C.D. Anderson discovered the antiparticle of the electron. It was the birth of elementary particle physics. Four years later the muon was discovered which was for many years wrongly assumed to be the carrier of the short range nuclear force predicted by H. Yukawa. One of the last high-lights before the particle accelerators took over this field of fundamental research was the discovery of the Yukawa particle. In photographic emulsions exposed by cosmic particles the pion was found in 1947. This

  14. Huntington's disease accelerates epigenetic aging of human brain and disrupts DNA methylation levels

    PubMed Central

    Horvath, Steve; Langfelder, Peter; Kwak, Seung; Aaronson, Jeff; Rosinski, Jim; Vogt, Thomas F.; Eszes, Marika; Faull, Richard L.M.; Curtis, Maurice A.; Waldvogel, Henry J.; Choi, Oi-Wa; Tung, Spencer; Vinters, Harry V.; Coppola, Giovanni; Yang, X. William

    2016-01-01

    Age of Huntington's disease (HD) motoric onset is strongly related to the number of CAG trinucleotide repeats in the huntingtin gene, suggesting that biological tissue age plays an important role in disease etiology. Recently, a DNA methylation based biomarker of tissue age has been advanced as an epigenetic aging clock. We sought to inquire if HD is associated with an accelerated epigenetic age. DNA methylation data was generated for 475 brain samples from various brain regions of 26 HD cases and 39 controls. Overall, brain regions from HD cases exhibit a significant epigenetic age acceleration effect (p=0.0012). A multivariate model analysis suggests that HD status increases biological age by 3.2 years. Accelerated epigenetic age can be observed in specific brain regions (frontal lobe, parietal lobe, and cingulate gyrus). After excluding controls, we observe a negative correlation (r=−0.41, p=5.5×10−8) between HD gene CAG repeat length and the epigenetic age of HD brain samples. Using correlation network analysis, we identify 11 co-methylation modules with a significant association with HD status across 3 broad cortical regions. In conclusion, HD is associated with an accelerated epigenetic age of specific brain regions and more broadly with substantial changes in brain methylation levels. PMID:27479945

  15. Huntington's disease accelerates epigenetic aging of human brain and disrupts DNA methylation levels.

    PubMed

    Horvath, Steve; Langfelder, Peter; Kwak, Seung; Aaronson, Jeff; Rosinski, Jim; Vogt, Thomas F; Eszes, Marika; Faull, Richard L M; Curtis, Maurice A; Waldvogel, Henry J; Choi, Oi-Wa; Tung, Spencer; Vinters, Harry V; Coppola, Giovanni; Yang, X William

    2016-07-01

    Age of Huntington's disease (HD) motoric onset is strongly related to the number of CAG trinucleotide repeats in the huntingtin gene, suggesting that biological tissue age plays an important role in disease etiology. Recently, a DNA methylation based biomarker of tissue age has been advanced as an epigenetic aging clock. We sought to inquire if HD is associated with an accelerated epigenetic age. DNA methylation data was generated for 475 brain samples from various brain regions of 26 HD cases and 39 controls. Overall, brain regions from HD cases exhibit a significant epigenetic age acceleration effect (p=0.0012). A multivariate model analysis suggests that HD status increases biological age by 3.2 years. Accelerated epigenetic age can be observed in specific brain regions (frontal lobe, parietal lobe, and cingulate gyrus). After excluding controls, we observe a negative correlation (r=-0.41, p=5.5×10-8) between HD gene CAG repeat length and the epigenetic age of HD brain samples. Using correlation network analysis, we identify 11 co-methylation modules with a significant association with HD status across 3 broad cortical regions. In conclusion, HD is associated with an accelerated epigenetic age of specific brain regions and more broadly with substantial changes in brain methylation levels. PMID:27479945

  16. Accelerated heat-aging studies on fluororubber in various media

    NASA Technical Reports Server (NTRS)

    Kalfayan, S. H.; Silver, R. H.; Liu, S. S.

    1976-01-01

    Heat-aging studies were conducted on fluororubber (copolymers of vinylidene fluoride and perfluoropropylene) using N,N-dicinnamylidene-1,6-hexanediamine, a Schiff's base of 1,6-hexanediamine, and MgO as acid acceptor. The principal technique employed was chemical stress relaxation for determining network changes brought about in the heat-aged fluororubber. This technique was backed up by swelling measurements, gel permeation chromatography, and IR spectroscopy. Stress relaxation curves are plotted for a wide range of variation in parameters (time, crosslinking density, state of curing, temperature, intermittent and continuous relaxation).

  17. Rapamycin suppresses brain aging in senescence-accelerated OXYS rats.

    PubMed

    Kolosova, Nataliya G; Vitovtov, Anton O; Muraleva, Natalia A; Akulov, Andrey E; Stefanova, Natalia A; Blagosklonny, Mikhail V

    2013-06-01

    Cellular and organismal aging are driven in part by the MTOR (mechanistic target of rapamycin) pathway and rapamycin extends life span inC elegans, Drosophila and mice. Herein, we investigated effects of rapamycin on brain aging in OXYS rats. Previously we found, in OXYS rats, an early development of age-associated pathological phenotypes similar to several geriatric disorders in humans, including cerebral dysfunctions. Behavioral alterations as well as learning and memory deficits develop by 3 months. Here we show that rapamycin treatment (0.1 or 0.5 mg/kg as a food mixture daily from the age of 1.5 to 3.5 months) decreased anxiety and improved locomotor and exploratory behavior in OXYS rats. In untreated OXYS rats, MRI revealed an increase of the area of hippocampus, substantial hydrocephalus and 2-fold increased area of the lateral ventricles. Rapamycin treatment prevented these abnormalities, erasing the difference between OXYS and Wister rats (used as control). All untreated OXYS rats showed signs of neurodegeneration, manifested by loci of demyelination. Rapamycin decreased the percentage of animals with demyelination and the number of loci. Levels of Tau and phospho-Tau (T181) were increased in OXYS rats (compared with Wistar). Rapamycin significantly decreased Tau and inhibited its phosphorylation in the hippocampus of OXYS and Wistar rats. Importantly, rapamycin treatment caused a compensatory increase in levels of S6 and correspondingly levels of phospo-S6 in the frontal cortex, indicating that some downstream events were compensatory preserved, explaining the lack of toxicity. We conclude that rapamycin in low chronic doses can suppress brain aging.

  18. Low intensity laser therapy accelerates muscle regeneration in aged rats

    PubMed Central

    Vatansever, Fatma; Rodrigues, Natalia C.; Assis, Livia L.; Peviani, Sabrina S.; Durigan, Joao L.; Moreira, Fernando M.A.; Hamblin, Michael R.; Parizotto, Nivaldo A.

    2013-01-01

    Background Elderly people suffer from skeletal muscle disorders that undermine their daily activity and quality of life; some of these problems can be listed as but not limited to: sarcopenia, changes in central and peripheral nervous system, blood hypoperfusion, regenerative changes contributing to atrophy, and muscle weakness. Determination, proliferation and differentiation of satellite cells in the regenerative process are regulated by specific transcription factors, known as myogenic regulatory factors (MRFs). In the elderly, the activation of MRFs is inefficient which hampers the regenerative process. Recent studies found that low intensity laser therapy (LILT) has a stimulatory effect in the muscle regeneration process. However, the effects of this therapy when associated with aging are still unknown. Objective This study aimed to evaluate the effects of LILT (λ=830 nm) on the tibialis anterior (TA) muscle of aged rats. Subjects and methods The total of 56 male Wistar rats formed two population sets: old and young, with 28 animals in each set. Each of these sets were randomly divided into four groups of young rats (3 months of age) with n=7 per group and four groups of aged rats (10 months of age) with n=7 per group. These groups were submitted to cryoinjury + laser irradiation, cryoinjury only, laser irradiation only and the control group (no cryoinjury/no laser irradiation). The laser treatment was performed for 5 consecutive days. The first laser application was done 24 h after the injury (on day 2) and on the seventh day, the TA muscle was dissected and removed under anesthesia. After this the animals were euthanized. Histological analyses with toluidine blue as well as hematoxylin-eosin staining (for counting the blood capillaries) were performed for the lesion areas. In addition, MyoD and VEGF mRNA was assessed by quantitative polymerase chain reaction. Results The results showed significant elevation (p<0.05) in MyoD and VEGF genes expression levels

  19. Effect of accelerated aging on the viscoelastic properties of a medical grade silicone.

    PubMed

    Mahomed, Aziza; Hukins, David W L; Kukureka, Stephen N

    2015-01-01

    The viscoelastic properties of cylinders (diameter 5 mm, height 2.2 ± 0.2 mm) of Nagor silicone elastomer of medium hardness, were investigated before and after the specimens had undergone accelerated aging in saline solution at 70°C for 38, 76 and 114 days (to simulate aging at 37°C, for 1, 2 and 3 years, respectively). All sets of specimens were immersed in physiological saline solution at 37°C during testing and the properties were measured using dynamic mechanical analysis (DMA). A sinusoidal cyclic compression of 40 N ± 5 N was applied over a frequency range, f, of 0.02-25 Hz. Values of the storage, E', and loss, E″, moduli were found to depend on f; the dependence of E' or E″ on the logarithm (base 10) of f was represented by a second-order polynomial. After accelerated aging, the E' and E″ values did not increase significantly (p<0.05). Furthermore, scanning electron microscopy (SEM) showed that accelerated aging did not affect the surface morphology of silicone. Attenuated total reflectance Fourier transform infra-red spectroscopy (ATR-FTIR) showed that accelerated aging had a negligible effect on the surface chemical structures of the material. Differential scanning calorimetry (DSC) showed no changes to the bulk properties of silicone, following accelerated aging.

  20. Interlaboratory reproducibility of standard accelerated aging methods for oxidation of UHMWPE.

    PubMed

    Kurtz, S M; Muratoglu, O K; Buchanan, F; Currier, B; Gsell, R; Greer, K; Gualtieri, G; Johnson, R; Schaffner, S; Sevo, K; Spiegelberg, S; Shen, F W; Yau, S S

    2001-07-01

    During accelerating aging, experimental uncertainty may arise due to variability in the oxidation process, or due to limitations in the technique that is ultimately used to measure oxidation. The purpose of the present interlaboratory study was to quantify the repeatability and reproducibility of standard accelerated aging methods for ultra-high molecular weight polyethylene (UHMWPE). Sections (200 microm thick) were microtomed from the center of an extruded rod of GUR 4150 HP, gamma irradiated in air or nitrogen, and circulated to 12 institutions in the United States and Europe for characterization of oxidation before and after accelerated aging. Specimens were aged for 3 weeks at 80 degrees C in an air circulating oven or for 2 weeks at 70 degrees C in an oxygen bomb (maintained at 503 kPa (5 atm.) of O2) in accordance with the two standard protocols described in ASTM F 2003-00. FTIR spectra were collected from each specimen within 24 h of the start and finish of accelerated aging, and oxidation indices were calculated by normalizing the peak area of the carbonyl region by the reference peak areas at 1370 or 2022 cm(-1). The mean relative interlaboratory uncertainty of the oxidation data was 78.5% after oven aging and 129.1% after bomb aging. The oxidation index measurement technique was not found to be a significant factor in the reproducibility. Comparable relative intrainstitutional uncertainty was observed after oven aging and bomb aging. For both aging methods, institutions successfully discriminated between air-irradiated and control specimens. However, the large interinstitutional variation suggests that absolute performance standards for the oxidation index of UHMWPE after accelerated aging may not be practical at the present time.

  1. Methodology for designing accelerated aging tests for predicting life of photovoltaic arrays

    NASA Technical Reports Server (NTRS)

    Gaines, G. B.; Thomas, R. E.; Derringer, G. C.; Kistler, C. W.; Bigg, D. M.; Carmichael, D. C.

    1977-01-01

    A methodology for designing aging tests in which life prediction was paramount was developed. The methodology builds upon experience with regard to aging behavior in those material classes which are expected to be utilized as encapsulant elements, viz., glasses and polymers, and upon experience with the design of aging tests. The experiences were reviewed, and results are discussed in detail.

  2. Traumatic stress, oxidative stress and posttraumatic stress disorder: neurodegeneration and the accelerated-aging hypothesis

    PubMed Central

    Miller, Mark W.; Sadeh, Naomi

    2014-01-01

    Posttraumatic stress disorder (PTSD) is associated with elevated risk for a variety of age-related diseases and neurodegeneration. In this paper, we review evidence relevant to the hypothesis that chronic PTSD constitutes a form of persistent life stress that potentiates oxidative stress (OXS) and accelerates cellular aging. We provide an overview of empirical studies that have examined the effects of psychological stress on OXS, discuss the stress-perpetuating characteristics of PTSD, and then identify mechanisms by which PTSD might promote OXS and accelerated aging. We review studies on OXS-related genes and the role that they may play in moderating the effects of PTSD on neural integrity and conclude with a discussion of directions for future research on antioxidant treatments and biomarkers of accelerated aging in PTSD. PMID:25245500

  3. Physical Property Changes in Plutonium from Accelerated Aging using Pu-238 Enrichment

    SciTech Connect

    Chung, B W; Choi, B W; Saw, C K; Thompson, S R; Woods, C H; Hopkins, D J; Ebbinghaus, B B

    2006-12-20

    We present changes in volume, immersion density, and tensile properties observed from accelerated aged plutonium alloys. Accelerated alloys (or spiked alloys) are plutonium alloys enriched with approximately 7.5 weight percent of the faster-decaying {sup 238}Pu to accelerate the aging process by approximately 17 times the rate of unaged weapons-grade plutonium. After sixty equivalent years of aging on spiked alloys, the dilatometry shows the samples at 35 C have swelled in volume by 0.15 to 0.17 % and now exhibit a near linear volume increase due to helium in-growth. The immersion density of spiked alloys shows a decrease in density, similar normalized volumetric changes (expansion) for spiked alloys. Tensile tests show increasing yield and engineering ultimate strength as spiked alloys are aged.

  4. Accelerated thermal aging of petroleum-based ferrofluids

    NASA Astrophysics Data System (ADS)

    Segal, V.; Nattrass, D.; Raj, K.; Leonard, D.

    1999-07-01

    The effect of elevated temperature on the physical and insulating properties of ferrofluid specifically developed for use as a liquid dielectric (D-fluid) for power transformers has been investigated. The D-fluid was produced as a colloidal mix of a specifically synthesized ferrofluid with a conventional mineral oil, and it was subjected to thermal aging conditions modeled after a typical power transformer where the insulation fluid is expected to retain its dielectric performance for about 40 years of continuous service in a sealed tank. The well-known Arrhenius relationship was employed to model "life in service" for up to 40 years at 105°C which corresponded to holding the samples in sealed jars for 10 weeks at 185°C. Another set of small ampules (5 ml) was prepared to test the main physical properties after even longer aging. D-fluid tested after a period of 34 and 50 weeks at 185°C showed no degradation of thermal or colloid stability. The dielectric colloid was also subjected to a 21 day-long test at 110°C in a sealed jar in the presence of typical transformer materials: copper, cellulose, and silicon steel (so-called "bomb" test). Finally, the ferrofluid went through an oxidation stability test (ASTM D2440). Test results show that the newly developed dielectric colloid satisfies the long-term service requirements the transformer users typically apply to conventional mineral oils.

  5. Isentropic compression experiments on the Sandia Z accelerator

    SciTech Connect

    HALL,CLINT A.

    2000-02-21

    A long-standing goal of the equation of state (EOS) community has been the development of a loading capability for direct measurement of material properties along an isentrope. Previous efforts on smooth bore launchers have been somewhat successful, but quite difficult to accurately reproduce, had pressure limitations, or tended to be a series of small shocks as opposed to a smoothly increasing pressure load. A technique has recently been developed on the Sandia National Laboratories Z accelerator which makes use of the high current densities and magnetic fields available to produce nearly isentropic compression of samples that are approximately 1 mm in thickness over approximately 120 ns. Velocity interferometry is used to measure the rear surface motion of these samples. The resulting time resolved velocity profiles from multiple sample thicknesses provide information about mechanical response under isentropic loading conditions and phase transition kinetics. Feasibility experiments have been performed to pressures of approximately 130 kbar in copper and 300 kbar in iron with effects of the {alpha}-{var_epsilon} phase change kinetics in iron clearly observed. Work is in progress to achieve 1--2% accuracy in P-v space along an isentrope, provide uniaxial strain, and to eliminate magnetic field and current diffusion within the sample of interest.

  6. Fluorescence intensity of resin composites and dental tissues before and after accelerated aging: a comparative study.

    PubMed

    Takahashi, Marcos Kenzo; Vieira, Sergio; Rached, Rodrigo Nunes; de Almeida, Janaina Bertoncelo; Aguiar, Marcelo; de Souza, Evelise Machado

    2008-01-01

    This study quantitatively evaluated the fluorescence intensity of resin composites with different opacities and translucencies and determined changes in fluorescence after accelerated aging, using human enamel and dentin as controls. Six microhybrid and nanofilled composites, each in three different shades, were tested. Ten sound human incisors were used to obtain enamel and dentin specimens separately. Fluorescence measurements were obtained with a fluorescence spectrophotometer before (baseline) and after accelerated aging at 150 kJ energy for 120 hours. One-way analysis of variance (ANOVA) and Games-Howell multiple comparison tests were performed at a significance level of 0.05. Student's t-test was also used for comparison before and after aging. At baseline, there was no statistically significant difference (p>0.05) between the fluorescence intensity of dentin and any of the shades of Charisma or Opallis, Esthet-X dentin shade or Vit-l-escence enamel, or the translucent shades. After accelerated aging, all shades of the 4 Seasons, enamel and the translucent shades of Esthet-X had fluorescence intensities statistically similar to that of aged dentin (p>0.05). A significant reduction in fluorescence after aging (p<0.05) was observed for all the materials, except for human enamel and translucent Filtek Supreme XT. Accelerated aging reduced fluorescence in most of the composites evaluated.

  7. Are Anxiety Disorders Associated with Accelerated Aging? A Focus on Neuroprogression

    PubMed Central

    Perna, Giampaolo; Iannone, Giuseppe; Alciati, Alessandra; Caldirola, Daniela

    2016-01-01

    Anxiety disorders (AnxDs) are highly prevalent throughout the lifespan, with detrimental effects on daily-life functioning, somatic health, and quality of life. An emerging perspective suggested that AnxDs may be associated with accelerated aging. In this paper, we explored the association between AnxDs and hallmarks of accelerated aging, with a specific focus on neuroprogression. We reviewed animal and human findings that suggest an overlap between processes of impaired neurogenesis, neurodegeneration, structural, functional, molecular, and cellular modifications in AnxDs, and aging. Although this research is at an early stage, our review suggests a link between anxiety and accelerated aging across multiple processes involved in neuroprogression. Brain structural and functional changes that accompany normal aging were more pronounced in subjects with AnxDs than in coevals without AnxDs, including reduced grey matter density, white matter alterations, impaired functional connectivity of large-scale brain networks, and poorer cognitive performance. Similarly, molecular correlates of brain aging, including telomere shortening, Aβ accumulation, and immune-inflammatory and oxidative/nitrosative stress, were overrepresented in anxious subjects. No conclusions about causality or directionality between anxiety and accelerated aging can be drawn. Potential mechanisms of this association, limitations of the current research, and implications for treatments and future studies are discussed. PMID:26881136

  8. Models of accelerated sarcopenia: critical pieces for solving the puzzle of age-related muscle atrophy.

    PubMed

    Buford, Thomas W; Anton, Stephen D; Judge, Andrew R; Marzetti, Emanuele; Wohlgemuth, Stephanie E; Carter, Christy S; Leeuwenburgh, Christiaan; Pahor, Marco; Manini, Todd M

    2010-10-01

    Sarcopenia, the age-related loss of skeletal muscle mass, is a significant public health concern that continues to grow in relevance as the population ages. Certain conditions have the strong potential to coincide with sarcopenia to accelerate the progression of muscle atrophy in older adults. Among these conditions are co-morbid diseases common to older individuals such as cancer, kidney disease, diabetes, and peripheral artery disease. Furthermore, behaviors such as poor nutrition and physical inactivity are well-known to contribute to sarcopenia development. However, we argue that these behaviors are not inherent to the development of sarcopenia but rather accelerate its progression. In the present review, we discuss how these factors affect systemic and cellular mechanisms that contribute to skeletal muscle atrophy. In addition, we describe gaps in the literature concerning the role of these factors in accelerating sarcopenia progression. Elucidating biochemical pathways related to accelerated muscle atrophy may allow for improved discovery of therapeutic treatments related to sarcopenia.

  9. Accelerated growth of calcium silicate hydrates: Experiments and simulations

    SciTech Connect

    Nicoleau, Luc

    2011-12-15

    Despite the usefulness of isothermal calorimetry in cement analytics, without any further computations this brings only little information on the nucleation and growth of hydrates. A model originally developed by Garrault et al. is used in this study in order to simulate hydration curves of cement obtained by calorimetry with different known hardening accelerators. The limited basis set of parameters used in this model, having a physical or chemical significance, is valuable for a better understanding of mechanisms underlying in the acceleration of C-S-H precipitation. Alite hydration in presence of four different types of hardening accelerators was investigated. It is evidenced that each accelerator type plays a specific role on one or several growth parameters and that the model may support the development of new accelerators. Those simulations supported by experimental observations enable us to follow the formation of the C-S-H layer around grains and to extract interesting information on its apparent permeability.

  10. Degradation of mechanical behavior in UHMWPE after natural and accelerated aging.

    PubMed

    Edidin, A A; Jewett, C W; Kalinowski, A; Kwarteng, K; Kurtz, S M

    2000-07-01

    Ultra-high molecular weight polyethylene (UHMWPE) is known to degrade during natural (shelf) aging following gamma irradiation in air, but the mechanical signature of degradation remains poorly understood. Accelerated aging methods have been developed to reproduce the natural aging process as well as to precondition total joint replacement components prior to joint simulator wear testing. In this study, we compared the mechanical behavior of naturally (shelf) aged and accelerated aged tibial inserts using a previously validated miniature specimen testing technique known as the small punch test. Tibial inserts made-of GUR 1120 and sterilized with 25 to 40 kGy of gamma radiation (in air) in 1988, 1993, and 1997 were obtained; a subset of the 1997 implants were subjected to 4 weeks of accelerated aging in air at 80 degrees C. To determine the spatial variation of mechanical properties within each insert, miniature disk shaped specimens were machined from the surface and subsurface regions of the inserts. Analysis of variance of the test data showed that aging significantly affected the small punch test measures of elastic modulus, initial load, ultimate load, ultimate displacement, and work to failure. The accelerated aging protocol was unable to reproduce the spatial mechanical profile seen in shelf aged components, but it did mechanically degrade the surface of GUR 1120 tibial components to an extent comparable to that seen after 10 years of natural aging. Test specimens showed a fracture morphology consistent with the decreased ductility and toughness which was corroborated by the small punch test metrics of this study. Our data support the hypothesis that UHMWPE undergoes a spatially nonuniform change towards a less ductile (more brittle) mechanical behavior after gamma irradiation in air and shelf aging.

  11. Accelerated epigenetic aging in brain is associated with pre-mortem HIV-associated neurocognitive disorders.

    PubMed

    Levine, Andrew J; Quach, Austin; Moore, David J; Achim, Cristian L; Soontornniyomkij, Virawudh; Masliah, Eliezer; Singer, Elyse J; Gelman, Benjamin; Nemanim, Natasha; Horvath, Steve

    2016-06-01

    HIV infection leads to age-related conditions in relatively young persons. HIV-associated neurocognitive disorders (HAND) are considered among the most prevalent of these conditions. To study the mechanisms underlying this disorder, researchers need an accurate method for measuring biological aging. Here, we apply a recently developed measure of biological aging, based on DNA methylation, to the study of biological aging in HIV+ brains. Retrospective analysis of tissue bank specimens and pre-mortem data was carried out. Fifty-eight HIV+ adults underwent a medical and neurocognitive evaluation within 1 year of death. DNA was obtained from occipital cortex and analyzed with the Illumina Infinium Human Methylation 450K platform. Biological age determined via the epigenetic clock was contrasted with chronological age to obtain a measure of age acceleration, which was then compared between those with HAND and neurocognitively normal individuals. The HAND and neurocognitively normal groups did not differ with regard to demographic, histologic, neuropathologic, or virologic variables. HAND was associated with accelerated aging relative to neurocognitively normal individuals, with average relative acceleration of 3.5 years. Age acceleration did not correlate with pre-mortem neurocognitive functioning or HAND severity. This is the first study to demonstrate that the epigenetic age of occipital cortex samples is associated with HAND status in HIV+ individuals pre-mortem. While these results suggest that the increased risk of a neurocognitive disorder due to HIV might be mediated by an epigenetic aging mechanism, future studies will be needed to validate the findings and dissect causal relationships and downstream effects. PMID:26689571

  12. Senescence-accelerated mouse (SAM): a biogerontological resource in aging research.

    PubMed

    Takeda, T

    1999-01-01

    The senescence-accelerated mouse (SAM), consisting of 14 senescence-prone inbred strains (SAMP) and 4 senescence-resistant inbred strains (SAMR) has been under development since 1970 through the selective inbreeding of AKR/J strain mice donated by the Jackson laboratory in 1968, based on the data of the grading score of senescence, life span, and pathologic phenotypes. The characteristic feature of aging common to all SAMP and SAMR mice is accelerated senescence and normal aging, respectively. Furthermore, SAMP and SAMR strains manifest various pathobiological phenotypes which include such neurobiological phenotypes as deficits in learning and memory, emotional disorders, abnormal circadian rhythms, brain atrophy, hearing impairment, etc., and are often characteristic enough to differentiate the strains. Various efforts are currently being made using the SAM model to clarify the underlying mechanisms in accelerated senescence as well as the etiopathogenic mechanisms in age-associated pathobiologies. Genetic background and significance of SAM development are discussed. PMID:10537019

  13. Effects of fibers on the color change and stability of resin composites after accelerated aging.

    PubMed

    Tuncdemir, Ali Riza; Aykent, Filiz

    2012-01-01

    Composite resins were reinforced with glass and polyethylene fibers in this study, and the effect of fiber reinforcement on the color change of composite resins was investigated. After accelerated aging, the effect of fiber reinforcement on the color stability of composite resins was also examined. There were three experimental groups (n=12 disks per group): non-fiber-reinforced composite (non-FRC control), polyethylene fiber (Ribbond-THM)-reinforced composite, and glass fiber (everstick NET)-reinforced composite. According to the critical remarks of color change of National Bureau of Standarts (NSB), glass fiber-reinforced anterior composites showed trace color change and polyethylene-fiber reinforced composites showed slight color change before accelerated aging. After accelerated aging, both control and fiber-reinforced composite groups showed noticeable color change. It was concluded that both the types of fiber reinforcement and composite resin influenced the color change of fiber-reinforced composite resins.

  14. Maladaptive autonomic regulation in PTSD accelerates physiological aging

    PubMed Central

    Williamson, John B.; Porges, Eric C.; Lamb, Damon G.; Porges, Stephen W.

    2015-01-01

    A core manifestation of post-traumatic stress disorder (PTSD) is a disconnection between physiological state and psychological or behavioral processes necessary to adequately respond to environmental demands. Patients with PTSD experience abnormal oscillations in autonomic states supporting either fight and flight behaviors or withdrawal, immobilization, and dissociation without an intervening “calm” state that would provide opportunities for positive social interactions. This defensive autonomic disposition is adaptive in dangerous and life threatening situations, but in the context of every-day life may lead to significant psychosocial distress and deteriorating social relationships. The perpetuation of these maladaptive autonomic responses may contribute to the development of comorbid mental health issues such as depression, loneliness, and hostility that further modify the nature of cardiovascular behavior in the context of internal and external stressors. Over time, changes in autonomic, endocrine, and immune function contribute to deteriorating health, which is potently expressed in brain dysfunction and cardiovascular disease. In this theoretical review paper, we present an overview of the literature on the chronic health effects of PTSD. We discuss the brain networks underlying PTSD in the context of autonomic efferent and afferent contributions and how disruption of these networks leads to poor health outcomes. Finally, we discuss treatment approaches based on our theoretical model of PTSD. PMID:25653631

  15. Accelerated ageing and renal dysfunction links lower socioeconomic status and dietary phosphate intake

    PubMed Central

    McClelland, Ruth; Christensen, Kelly; Mohammed, Suhaib; McGuinness, Dagmara; Cooney, Josephine; Bakshi, Andisheh; Demou, Evangelia; MacDonald, Ewan; Caslake, Muriel; Stenvinkel, Peter; Shiels, Paul G.

    2016-01-01

    Background We have sought to explore the impact of dietary Pi intake on human age related health in the pSoBid cohort (n=666) to explain the disparity between health and deprivation status in this cohort. As hyperphosphataemia is a driver of accelerated ageing in rodent models of progeria we tested whether variation in Pi levels in man associate with measures of biological ageing and health. Results We observed significant relationships between serum Pi levels and markers of biological age (telomere length (p=0.040) and DNA methylation content (p=0.028), gender and chronological age (p=0.032). When analyses were adjusted for socio-economic status and nutritional factors, associations were observed between accelerated biological ageing (telomere length, genomic methylation content) and dietary derived Pi levels among the most deprived males, directly related to the frequency of red meat consumption. Conclusions Accelerated ageing is associated with high serum Pi levels and frequency of red meat consumption. Our data provide evidence for a mechanistic link between high intake of Pi and age-related morbidities tied to socio-economic status. PMID:27132985

  16. Evolution of morphology in UHMWPE following accelerated aging: the effect of heating rates.

    PubMed

    Kurtz, S M; Pruitt, L A; Crane, D J; Edidin, A A

    1999-07-01

    Accelerated aging methods are used to evaluate the oxidative stability of UHMWPE components for total joint replacements. In this study, we traced the evolution of the crystalline morphology during accelerated thermal aging of UHMWPE in air with the intent of explaining previous, counterintuitive heating rate effects. GUR4150HP extruded rod stock material was machined into miniature (0.5 mm thick) specimens that were either gamma irradiated in air or in nitrogen (27 +/- 3 kGy) or left unirradiated (control). Accelerated aging in an air furnace (at 80 degrees C, atmospheric pressure) was performed on half of the test samples at a heating rate of 0.1 degrees C/min and at 5 degrees C/min for the remaining half. Although the initial heating rate, as measured by changes in density, did influence the absolute degradation rate by up to 214%, the heating rate effect did not appear to influence the relative ranking of UHMWPE in terms of its oxidative stability. The heating rate effect is more consistent with a kinetic mechanism of the oxidation process than it is with a previously hypothesized diffusion mechanism. UHMWPE morphology, as characterized using a transmission electron microscope (TEM), demonstrated considerable rearrangement of the crystalline regions as a result of the accelerated aging. The stacking of the lamellae observed after accelerated aging was not consistent with the morphology of naturally aged UHMWPE components. The observed differences in crystalline morphology likely result from the enhanced mobility of the polymer chains due to thermal aging and may be analogous to an annealing process.

  17. Seismic-fragility tests of new and accelerated-aged Class 1E battery cells

    SciTech Connect

    Bonzon, L.L.; Janis, W.J.; Black, D.A.; Paulsen, G.A.

    1987-01-01

    The seismic-fragility response of naturally-aged nuclear station safety-related batteries is of interest for two reasons: (1) to determine actual failure modes and thresholds and (2) to determine the validity of using the electrical capacity of individual cells as an indicator of the potential survivability of a battery given a seismic event. Prior reports in this series discussed the seismic-fragility tests and results for three specific naturally-aged cell types: 12-year old NCX-2250, 10-year old LCU-13, and 10-year old FHC-19. This report focuses on the complementary approach, namely, the seismic-fragility response of accelerated-aged batteries. Of particular interest is the degree to which such approaches accurately reproduce the actual failure modes and thresholds. In these tests the significant aging effects observed, in terms of seismic survivability, were: embrittlement of cell cases, positive bus material and positive plate grids; and excessive sulphation of positive plate active material causing hardening and expansion of positive plates. The IEEE Standard 535 accelerated aging method successfully reproduced seismically significant aging effects in new cells but accelerated grid embrittlement an estimated five years beyond the conditional age of other components.

  18. A methodology for examining the plausibility of accelerated aging protocols for UHMWPE components.

    PubMed

    Lewis, G; Nyman, J S; Trieu, H H

    1998-01-01

    In light of the time-intensive nature of using real-time shelf-aged specimens in research into property changes of ultra-high-molecular-weight polyethylene (UHMWPE), accelerated thermal diffusion oxidative aging (usually referred to as accelerated aging) is frequently resorted to. A number of such aging protocols have been reported in the literature, with various claims for their producing changes in the properties of the polymer being the same as or similar to those seen in real-time shelf-aged samples. The thrust of the present work is the presentation of a methodology for examining such claims. The methodology is applied to six properties (% crystallinity, melting temperature, oxidation index, ultimate tensile strength, ultimate tensile elongation, and tensile toughness) of 4150HP UHMWPE grade, sterilized using six different methods, prior to and following the use of a specific accelerated aging protocol (oxygen gas at 70 degrees C and 507 kPa pressure; 14 d.). These six properties have been identified in the literature as being strongly correlated with the clinical wear of UHMWPE articular components. It is shown that the claim for the protocol used in the present work (in terms of the simulated equivalent shelf aging time) is plausible. It needs to be emphasized, however, that this conclusion is tentative given the paucity of the relevant literature results that are currently available and which are vital to the application of the methodology.

  19. Effect of an accelerated aging protocol on viscoelastic properties of UHMWPE.

    PubMed

    Lewis, Gladius

    2002-01-01

    The values of two viscoelastic properties (storage modulus and loss angle) of four sets of ultra-high-molecular-weight polyethylene specimens were obtained. Two sets comprised specimens that had been sterilized (using gamma radiation in air or ethylene oxide gas) while the other two sets comprised specimens that were sterilized and then exposed to an accelerated aging protocol that, in the literature, has been proposed as simulating 5 years of real-time shelf aging. An analysis of the present results from the four specimen sets and those obtained, in a previous study by the present author, on specimens machined from real-time shelf aged tibial inserts suggests that the claim made for the accelerated aging protocol may be conservative.

  20. Experiments on hypersonic ramjet propulsion cycles using a ram accelerator

    NASA Technical Reports Server (NTRS)

    Chew, G.; Knowlen, C.; Burnham, E. A.; Hertzberg, A.; Bruckner, A. P.

    1991-01-01

    Work on hypersonic propulsion research using a ram accelerator is presented. Several different ram accelerator propulsive cycles have been experimentally demonstrated over the Mach number range of 3 to 8.5. The subsonic, thermally choked combustion mode has accelerated projectiles to near the Chapman-Jouguet (C-J) detonation velocity within many different propellant mixtures. In the transdetonative velocity regime (85 to 115 percent of C-J speed), projectiles have established a propulsive cycle which allows them to transition smoothly from subdetonative to superdetonative velocities. Luminosity data indicate that the combustion process moves forward onto the projectile body as it approaches the C-J speed. In the superdetonative velocity range, the projectiles accelerate while always traveling faster than the C-J velocity. Ram accelerator projectiles operating continuously through these velocity regimes generate distinctive hypersonic phenomena which can be studied very effectively in the laboratory. These results would be very useful for validating sophisticated CFD computer codes and in collecting engineering data for potential airbreathing hypersonic propulsive systems.

  1. AWAKE, The Advanced Proton Driven Plasma Wakefield Acceleration Experiment at CERN

    NASA Astrophysics Data System (ADS)

    Gschwendtner, E.; Adli, E.; Amorim, L.; Apsimon, R.; Assmann, R.; Bachmann, A.-M.; Batsch, F.; Bauche, J.; Berglyd Olsen, V. K.; Bernardini, M.; Bingham, R.; Biskup, B.; Bohl, T.; Bracco, C.; Burrows, P. N.; Burt, G.; Buttenschön, B.; Butterworth, A.; Caldwell, A.; Cascella, M.; Chevallay, E.; Cipiccia, S.; Damerau, H.; Deacon, L.; Dirksen, P.; Doebert, S.; Dorda, U.; Farmer, J.; Fedosseev, V.; Feldbaumer, E.; Fiorito, R.; Fonseca, R.; Friebel, F.; Gorn, A. A.; Grulke, O.; Hansen, J.; Hessler, C.; Hofle, W.; Holloway, J.; Hüther, M.; Jaroszynski, D.; Jensen, L.; Jolly, S.; Joulaei, A.; Kasim, M.; Keeble, F.; Li, Y.; Liu, S.; Lopes, N.; Lotov, K. V.; Mandry, S.; Martorelli, R.; Martyanov, M.; Mazzoni, S.; Mete, O.; Minakov, V. A.; Mitchell, J.; Moody, J.; Muggli, P.; Najmudin, Z.; Norreys, P.; Öz, E.; Pardons, A.; Pepitone, K.; Petrenko, A.; Plyushchev, G.; Pukhov, A.; Rieger, K.; Ruhl, H.; Salveter, F.; Savard, N.; Schmidt, J.; Seryi, A.; Shaposhnikova, E.; Sheng, Z. M.; Sherwood, P.; Silva, L.; Soby, L.; Sosedkin, A. P.; Spitsyn, R. I.; Trines, R.; Tuev, P. V.; Turner, M.; Verzilov, V.; Vieira, J.; Vincke, H.; Wei, Y.; Welsch, C. P.; Wing, M.; Xia, G.; Zhang, H.

    2016-09-01

    The Advanced Proton Driven Plasma Wakefield Acceleration Experiment (AWAKE) aims at studying plasma wakefield generation and electron acceleration driven by proton bunches. It is a proof-of-principle R&D experiment at CERN and the world's first proton driven plasma wakefield acceleration experiment. The AWAKE experiment will be installed in the former CNGS facility and uses the 400 GeV/c proton beam bunches from the SPS. The first experiments will focus on the self-modulation instability of the long (rms ~12 cm) proton bunch in the plasma. These experiments are planned for the end of 2016. Later, in 2017/2018, low energy (~15 MeV) electrons will be externally injected into the sample wakefields and be accelerated beyond 1 GeV. The main goals of the experiment will be summarized. A summary of the AWAKE design and construction status will be presented.

  2. Exposure to light at night accelerates aging and spontaneous uterine carcinogenesis in female 129/Sv mice

    PubMed Central

    Popovich, Irina G.; Zabezhinski, Mark A.; Panchenko, Andrei V.; Piskunova, Tatiana S.; Semenchenko, Anna V.; Tyndyk, Maragriata L.; Yurova, Maria N.; Anisimov, Vladimir N.

    2013-01-01

    The effect of the constant illumination on the development of spontaneous tumors in female 129/Sv mice was investigated. Forty-six female 129/Sv mice starting from the age of 2 mo were kept under standard light/dark regimen [12 h light (70 lx):12hr dark; LD, control group], and 46 of 129/Sv mice were kept under constant illumination (24 h a day, 2,500 lx, LL) from the age of 5 mo until to natural death. The exposure to the LL regimen significantly accelerated body weight gain, increased body temperature as well as acceleration of age-related disturbances in estrous function, followed by significant acceleration of the development of the spontaneous uterine tumors in female 129/Sv mice. Total tumor incidence as well as a total number of total or malignant tumors was similar in LL and LD group (p > 0.05). The mice from the LL groups survived less than those from the LD group (χ2 = 8.5; p = 0.00351, log-rank test). According to the estimated parameters of the Cox’s regression model, constant light regimen increased the relative risk of death in female mice compared with the control (LD) group (p = 0.0041). The data demonstrate in the first time that the exposure to constant illumination was followed by the acceleration of aging and spontaneous uterine tumorigenesis in female 129/Sv mice. PMID:23656779

  3. Effect ofartificial accelerated aging on color stability and surface roughness of indirect composites.

    PubMed

    Zanin, Fabíola Rejane; Garcia, Lucas da Fonseca Roberti; Casemiro, Luciana Assirati; Pires-de-Souza, Fernanda de Carvalho Panzeri

    2008-03-01

    Direct and indirect composite resins have different forms of polymerization. Some materials require a post-cure system associating light and heat enhancing clinical properties. This study assessed the changes in color and surface roughness of three indirect composite resins after accelerated aging. Twelve specimens (15 x 2 mm) were obtained for each tested material. Subsequently, the first measurements for roughness tests and colorimetric spectrophotometry (CIE L*a*b* scale) were performed. Specimens were subject to accelerated aging for 384 hours. New measurements were then performed to evaluate the resulting change. Accelerated aging produced color change and increased surface roughness in all composite resins. Solidex resin showed color changes above the clinically accepted value (DeltaE = 4.31 +/- 0.22), and roughness values (Ra = 0.088 +/- 0.008 microm) statistically lower than that of Artglass (Ra = 0.141 +/- 0.026 microm) and Targis (Ra = 0.124 +/- 0.02 microm) (p<0.001). All the indirect resins tested showed color change and increased roughness after accelerated aging. Solidex showed color stability above a quantitative level considered clinically acceptable and lower roughness values compared to the other resins.

  4. Acceleration units for the Induction Linac Systems Experiment (ILSE)

    SciTech Connect

    Faltens, A.; Brady, V.; Brodzik, D.; Hansen, L.; Laslett, L.J.; Mukherjee, S.; Bubp, D.; Ravenscroft, D.; Reginato, L.

    1989-03-01

    The design of a high current heavy ion induction linac driver for inertial confinement fusion is optimized by adjusting the acceleration units along the length of the accelerator to match the beam current, energy, and pulse duration at any location. At the low energy end of the machine the optimum is a large number of electrostatically focused parallel beamlets, whereas at higher energies the optimum is a smaller number of magnetically focused beams. ILSE parallels this strategy by using 16 electrostatically focused beamlets at the low end followed by 4 magnetically focused beams after beam combining. 3 refs., 2 figs.

  5. Two-Channel Rectangular Dielectric Wake Field Accelerator Structure Experiment

    SciTech Connect

    Sotnikov, G. V.; Marshall, T. C.; Shchelkunov, S. V.; Didenko, A.; Hirshfield, J. L.

    2009-01-22

    A design is presented for a two-channel 30-GHz rectangular dielectric wake field accelerator structure being built for experimental tests at Argonne National Laboratory (ANL). This structure allows for a transformer ratio T much greater than two, and permits continuous coupling of energy from drive bunches to accelerated bunches. It consists of three planar slabs of cordierite ceramic ({epsilon} = 4.7) supported within a rectangular copper block, forming a drive channel 12 mmx6 mm, and an accelerator channel 2 mmx6 mm. When driven by a 50 nC, 14 MeV single bunch available at ANL, theory predicts an acceleration field of 6 MeV/m, and T = 12.6. Inherent transverse wake forces introduce deflections and some distortion of bunch profiles during transit through the structure that are estimated to be tolerable. Additionally, a cylindrical two-channel DWFA is introduced which shares many advantages of the rectangular structure including high T, and the added virtue of axisymmetry that eliminates lowest-order transverse deflecting forces.

  6. RF ACCELERATING STRUCTURE FOR THE MUON COOLING EXPERIMENT.

    SciTech Connect

    CORLETT,J.; GREEN,M.; LI,D.; HOLTKAMP,N.; MORETTI,A.; KIRK,H.G.; PALMER,R.B.; ZHAO,Y.; SUMMERS,D.

    1999-03-29

    The ionization cooling of muons requires longitudinal acceleration of the muons after scattering in a hydrogen target. In order to maximize the accelerating voltage, we propose using linear accelerating structures with cells bounded by thin beryllium metal foils. This produces an on-axis field equivalent to the maximum surface field, whereas with beam-pipes the accelerating field is approximately half that of the peak surface field in the cavity. The muons interact only weakly with the thin foils. A {pi}/2 interleaved cavity structure has been chosen, with alternate cells coupled together externally, and the two groups of cells fed in quadrature. At present they are considering an operating temperature of 77K to gain a factor of at least two in Q-value over room temperature. The authors describe the design of the {pi}/2 interleaved cavity structure, design of an alternative {pi}-mode open structure, preliminary experimental results from a low-power test cavity, and plans for high-power testing.

  7. Present and future high-energy accelerators for neutrino experiments

    SciTech Connect

    Kourbanis, I.; /Fermilab

    2007-06-01

    There is an active neutrino program making use of the high-energy (larger than 50 GeV) accelerators both in USA at Fermilab with NuMI and at CERN in Europe with CNGS. In this paper we will review the prospects for high intensity high energy beams in those two locations during the next decade.

  8. Prediction of brain age suggests accelerated atrophy after traumatic brain injury

    PubMed Central

    Cole, James H; Leech, Robert; Sharp, David J

    2015-01-01

    Objective The long-term effects of traumatic brain injury (TBI) can resemble observed in normal ageing, suggesting that TBI may accelerate the ageing process. We investigate this using a neuroimaging model that predicts brain age in healthy individuals and then apply it to TBI patients. We define individuals' differences in chronological and predicted structural "brain age," and test whether TBI produces progressive atrophy and how this relates to cognitive function. Methods A predictive model of normal ageing was defined using machine learning in 1,537 healthy individuals, based on magnetic resonance imaging–derived estimates of gray matter (GM) and white matter (WM). This ageing model was then applied to test 99 TBI patients and 113 healthy controls to estimate brain age. Results The initial model accurately predicted age in healthy individuals (r * 0.92). TBI brains were estimated to be "older," with a mean predicted age difference (PAD) between chronological and estimated brain age of 4.66 years (±10.8) for GM and 5.97 years (±11.22) for WM. This PAD predicted cognitive impairment and correlated strongly with the time since TBI, indicating that brain tissue loss increases throughout the chronic postinjury phase. Interpretation TBI patients' brains were estimated to be older than their chronological age. This discrepancy increases with time since injury, suggesting that TBI accelerates the rate of brain atrophy. This may be an important factor in the increased susceptibility in TBI patients for dementia and other age-associated conditions, motivating further research into the age-like effects of brain injury and other neurological diseases. PMID:25623048

  9. Compatibility and accelerated aging study for Li(Si)/FeS/sub 2 thermally activated batteries

    NASA Astrophysics Data System (ADS)

    Mead, J. W.; Searcy, J. Q.; Neiswander, P. N.; Poole, R. L.

    1983-12-01

    Thermally activated batteries using the lithium (silicon) iron disulfide (Li(Si)/FeS2) electrochemical system are used in weapons having a required storage life of 25 years and high reliability. A review of known data revealed no information on the compatibility of Li(Si)/FeS2 with the organic materials used in the system. The compatibility question is studied. Accelerated-aging data on pairs of materials were produced. In addition, a group of production batteries was aged and tested. Three aging temperatures were used during the one-year study. Gas analyses, electrical tests and mechanical tests were compared for control and aged samples. Two results, the depletion of oxygen and an increase in hydrogen in the compatibility and accelerated-aging samples, stimulated additional studies. No unexpected or significant changes were observed in the electrical or mechanical properties of the organic materials. Calorific output and chloride ion content of heat pellets indicated no degradation with aging. Ignition sensitivity and burn rate measurements suggested no heat pellet degradation. Oxygen content in aged lithium (silicon) anodes remained within acceptable limits. Single-cell tests and battery test results showed no degradation with aging.

  10. The role of oxidative and nitrosative stress in accelerated aging and major depressive disorder.

    PubMed

    Maurya, Pawan Kumar; Noto, Cristiano; Rizzo, Lucas B; Rios, Adiel C; Nunes, Sandra O V; Barbosa, Décio Sabbatini; Sethi, Sumit; Zeni, Maiara; Mansur, Rodrigo B; Maes, Michael; Brietzke, Elisa

    2016-02-01

    Major depressive disorder (MDD) affects millions of individuals and is highly comorbid with many age associated diseases such as diabetes mellitus, immune-inflammatory dysregulation and cardiovascular diseases. Oxidative/nitrosative stress plays a fundamental role in aging, as well as in the pathogenesis of neurodegenerative/neuropsychiatric disorders including MDD. In this review, we critically review the evidence for an involvement of oxidative/nitrosative stress in acceleration of aging process in MDD. There are evidence of the association between MDD and changes in molecular mechanisms involved in aging. There is a significant association between telomere length, enzymatic antioxidant activities (SOD, CAT, GPx), glutathione (GSH), lipid peroxidation (MDA), nuclear factor κB, inflammatory cytokines with MDD. Major depression also is characterized by significantly lower concentration of antioxidants (zinc, coenzyme Q10, PON1). Since, aging and MDD share a common biological base in their pathophysiology, the potential therapeutic use of antioxidants and anti-aging molecules in MDD could be promising.

  11. Effect of accelerated aging on the microhardness and color stability of flexible resins for dentures.

    PubMed

    Goiato, Marcelo Coelho; Santos, Daniela Micheline dos; Haddad, Marcela Filie; Pesqueira, Aldiéris Alves

    2010-01-01

    Acrylic resins have been widely used due to their acceptable esthetics and desirable characteristics such as easy handling, good thermal conductivity, low permeability to oral fluids and color stability. Flexible resins were introduced on the market as an alternative to the use of conventional acrylic resins in the construction of complete and partial removable dentures. Although these resins present advantages in terms of esthetics and comfort, studies assessing chromatic and microhardness alterations of these materials are still scarce in the related literature. The aim of this study was to evaluate the chromatic and microhardness alterations of two commercial brands of flexible resins in comparison to the conventional resin Triplex when submitted to accelerated aging. The resins were manipulated according to manufacturers' instructions and inserted into a silicone matrix to obtain 21 specimens divided into 3 groups: Triplex, Ppflex and Valplast. Triplex presented the highest microhardness value (p < 0.05) for all the aging periods, which was significantly different from that of the other resins, followed by the values of Valplast and Ppflex. Comparison between the flexible resins (Ppflex and Valplast) revealed a statistically significant difference (p < 0.05) as regards color. The flexible resin Ppflex and the conventional resin Triplex presented no statistically significant difference (p < 0.05) as regards aging. The accelerated aging significantly increased the microhardness values of the resins, with the highest values being observed for Triplex. Valplast presented the greatest chromatic alteration after accelerated aging. PMID:20339724

  12. In vitro cytotoxicity of maxillofacial silicone elastomers: effect of accelerated aging.

    PubMed

    Bal, Bilge Turhan; Yilmaz, Handan; Aydin, Cemal; Karakoca, Seçil; Yilmaz, Sükran

    2009-04-01

    The purpose of this in vitro study was to evaluate the cytotoxicity of three maxillofacial silicone elastomers at 24, 48, and 72 h on L-929 cells and to determine the effect of accelerated aging on the cytotoxicity of these silicone elastomers. Disc-shaped test samples of maxillofacial silicone elastomers (Cosmesil, Episil, Multisil) were fabricated according to manufacturers' instructions under aseptic conditions. Samples were then divided into three groups: (1) not aged; (2) aged for 150 h with an accelerated weathering tester; and (3) aged for 300 h. Then the samples were placed in Dulbecco's Modified Eagle Medium/Ham's F12 (DMEM/F12) for 24, 48, and 72 h. After the incubation periods, cytotoxicity of the extracts to cultured fibroblasts (L-929) was measured by MTT assay. The degree of cytotoxicity of each sample was determined according to the reference value represented by the cells with a control (culture without sample). Statistical significance was determined by repeated measurement ANOVA (p < 0.01) followed by Duncan's test (p < 0.05). All test materials in each group demonstrated high survival rates in MTT assay (Episil; 93.84%, Multisil; 88.30%, Cosmesil; 87.50%, respectively); however, in all groups, Episil material demonstrated significantly higher cell survival rate after each of the experimental incubation periods (p < 0.05). Accelerated aging for 150 and 300 h had no significant effect on the biocompatibility of maxillofacial silicone elastomers tested (p > 0.05).

  13. Acceleration factors for oxidative aging of polymeric materials by oxygen detection.

    SciTech Connect

    Assink, Roger Alan; Celina, Mathias Christopher; Skutnik, Julie Michelle

    2005-01-01

    Three methods that were used to measure the chemical changes associated with oxidative degradation of polymeric materials are presented. The first method is based on the nuclear activation of {sup 18}O in an elastomer that was thermally aged in an {sup 18}O{sub 2} atmosphere. Second, the alcohol groups in a thermally aged elastomer were derivatized with trifluoroacetic anhydride and their concentration measured via {sup 19}F NMR spectroscopy. Finally, a respirometer was used to directly measure the oxidative rates of a polyurethane foam as a function of aging temperature. The measurement of the oxidation rates enabled acceleration factors for oxidative degradation of these materials to be calculated.

  14. Accelerator physics of the Stanford Linear Collider and SLC accelerator experiments towards the Next Linear Collider

    SciTech Connect

    Seeman, J.T.

    1992-06-01

    The Stanford Linear Collider (SLC) was built to collide single bunches of electrons and positrons head-on at a single interaction point with single beam energies up to 55 GeV. The small beam sizes and high currents required for high luminosity operation have significantly pushed traditional beam quality limits. The Polarized Electron Source produces about 8 {times} 10{sup 10} electrons in each of two bunches with up to 28% polarization,. The Damping Rings provide coupled invariant emittances of 1.8 {times} 10{sup {minus}5} r-m with 4.5 {times} 10{sup 10} particles per bunch. The 57 GeV Linac has successfully accelerated over 3 {times} 10{sup 10} particles with design invariant emittances of 3 {times} 10{sup {minus}5} r-m. Both longitudinal and transverse wakefields affect strongly the trajectory and emittance corrections used for operations. The Arc systems routinely transport decoupled and betatron matched beams. In the Final Focus, the beams are chromatically corrected and demagnified producing spot sizes of 2 to 3 {mu}m at the focal point. Spot sizes below 2 {mu}m have been made during special tests. Instrumentation and feedback systems are well advanced, providing continuous beam monitoring and pulse-by-pulse control. A luminosity of 1.6 {times} 10{sup 29} cm{sup {minus}2}sec{sup {minus}1} has been produced. Several experimental tests for a Next Linear Collider (NLC) are being planned or constructed using the SLC accelerator as a test facility. The Final Focus Test Beam will demagnify a flat 50 GeV electron beam to dimensions near 60 nm vertically and 900 nm horizontally. A potential Emittance Dynamics Test Area has the capability to test the acceleration and transport of very low emittance beams, the compression of bunch lengths to 50 {mu}m, the acceleration and control of multiple bunches, and the properties of wakefields in the very short bunch length regime.

  15. DIANA - A deep underground accelerator for nuclear astrophysics experiments

    NASA Astrophysics Data System (ADS)

    Winklehner, Daniel; Lemut, Alberto; Leitner, Daniela; Couder, Manoel; Hodgkinson, Adrian; Wiescher, Michael

    2013-04-01

    DIANA (Dakota Ion Accelerator for Nuclear Astrophysics) is a proposed facility designed to be operated deep underground. The DIANA collaboration includes nuclear astrophysics groups from Lawrence Berkeley National Laboratory, Michigan State University, Western Michigan University, Colorado School of Mines, and the University of North Carolina, and is led by the University of Notre Dame. The scientific goals of the facility are measurements of low energy nuclear cross-sections associated with sun and pre-supernova stars in a laboratory setup at energies that are close to those in stars. Because of the low stellar temperatures associated with these environments, and the high Coulomb barrier, the reaction cross-sections are extremely low. Therefore these measurements are hampered by small signal to background ratios. By going underground the background due to cosmic rays can be reduced by several orders of magnitude. We report on the design status of the DIANA facility with focus on the 3 MV electrostatic accelerator.

  16. DIANA - A deep underground accelerator for nuclear astrophysics experiments

    SciTech Connect

    Winklehner, Daniel; Leitner, Daniela; Lemut, Alberto; Hodgkinson, Adrian; Couder, Manoel; Wiescher, Michael

    2013-04-19

    DIANA (Dakota Ion Accelerator for Nuclear Astrophysics) is a proposed facility designed to be operated deep underground. The DIANA collaboration includes nuclear astrophysics groups from Lawrence Berkeley National Laboratory, Michigan State University, Western Michigan University, Colorado School of Mines, and the University of North Carolina, and is led by the University of Notre Dame. The scientific goals of the facility are measurements of low energy nuclear cross-sections associated with sun and pre-supernova stars in a laboratory setup at energies that are close to those in stars. Because of the low stellar temperatures associated with these environments, and the high Coulomb barrier, the reaction cross-sections are extremely low. Therefore these measurements are hampered by small signal to background ratios. By going underground the background due to cosmic rays can be reduced by several orders of magnitude. We report on the design status of the DIANA facility with focus on the 3 MV electrostatic accelerator.

  17. Development of a lifetime prediction model for lithium-ion batteries based on extended accelerated aging test data

    NASA Astrophysics Data System (ADS)

    Ecker, Madeleine; Gerschler, Jochen B.; Vogel, Jan; Käbitz, Stefan; Hust, Friedrich; Dechent, Philipp; Sauer, Dirk Uwe

    2012-10-01

    Battery lifetime prognosis is a key requirement for successful market introduction of electric and hybrid vehicles. This work aims at the development of a lifetime prediction approach based on an aging model for lithium-ion batteries. A multivariable analysis of a detailed series of accelerated lifetime experiments representing typical operating conditions in hybrid electric vehicle is presented. The impact of temperature and state of charge on impedance rise and capacity loss is quantified. The investigations are based on a high-power NMC/graphite lithium-ion battery with good cycle lifetime. The resulting mathematical functions are physically motivated by the occurring aging effects and are used for the parameterization of a semi-empirical aging model. An impedance-based electric-thermal model is coupled to the aging model to simulate the dynamic interaction between aging of the battery and the thermal as well as electric behavior. Based on these models different drive cycles and management strategies can be analyzed with regard to their impact on lifetime. It is an important tool for vehicle designers and for the implementation of business models. A key contribution of the paper is the parameterization of the aging model by experimental data, while aging simulation in the literature usually lacks a robust empirical foundation.

  18. [Anti-aging studies on the senescence accelerated mouse (SAM) strains].

    PubMed

    Takahashi, Ryoya

    2010-01-01

    Senescence accelerated mouse (SAM), a murine model of accelerated senescence, was established by Toshio Takeda and colleagues. SAM consists of series of SAMP (prone) and SAMR (resistant) lines. All SAMP lines (from SAMP1 to SAMP11) are characterized by accelerated accumulation of senile features, earlier onset and faster progress of age-associated pathological phenotypes, such as amyloidosis, impaired immune response, senile osteoporosis and deficits in learning and memory. These SAMP lines are useful for evaluation of putative anti-aging therapies. For example, SAMP1 line is used to study the anti-aging effect of the antioxidant containing foods and various anti-oxidants, such as coenzyme Q10, vitamin C, lycopene. SAMP8 line exhibiting an early onset of impaired learning and memory is often used for test strategies for therapeutic intervention of dementia of early onset. SAMP6 is used as an animal model for developing new strategies for the treatment of osteoporosis in humans. Various lines of SAM (P1, P6, P8, P10 and R1) are now commercially available for research. In this review, I will briefly introduce various usages of SAM in anti-aging research. PMID:20046059

  19. Advocacy and Age: Issues, Experiences, Strategies.

    ERIC Educational Resources Information Center

    Kerschner, Paul A., Ed.

    This monograph seeks to bring understanding to one component of the advocacy field, that of advocacy and the aged, by overviewing this component through a series of articles. (Advocacy is an activity by which changes can be effected in a power structure to improve a subgroup's situation.) There are four parts to the document: part 1, entitled…

  20. Gamma radiation and magnetic field mediated delay in effect of accelerated ageing of soybean.

    PubMed

    Kumar, Mahesh; Singh, Bhupinder; Ahuja, Sumedha; Dahuja, Anil; Anand, Anjali

    2015-08-01

    Soybean seeds were exposed to gamma radiation (0.5, 1, 3 and 5 kGy), static magnetic field (50, 100 and 200 mT) and a combination of gamma radiation and magnetic energy (0.5 kGy + 200 mT and 5 kGy + 50 mT) and stored at room temperature for six months. These seeds were later subjected to accelerated ageing treatment at 42 °C temperature and 95-100 % relative humidity and were compared for various physical and biochemical characteristics between the untreated and the energized treatments. Energy treatment protected the quality of stored seeds in terms of its protein and oil content . Accelerated aging conditions, however, affected the oil and protein quantity and quality of seed negatively. Antioxidant enzymes exhibited a decline in their activity during aging while the LOX activity, which reflects the rate of lipid peroxidation, in general, increased during the aging. Gamma irradiated (3 and 5 kGy) and magnetic field treated seeds (100 and 200 mT) maintained a higher catalase and ascorbate peroxidase activity which may help in efficient scavenging of deleterious free radical produced during the aging. Aging caused peroxidative changes to lipids, which could be contributed to the loss of oil quality. Among the electromagnetic energy treatments, a dose of 1-5 kGy of gamma and 100 mT, 200 mT magnetic field effectively slowed the rate of biochemical degradation and loss of cellular integrity in seeds stored under conditions of accelerated aging and thus, protected the deterioration of seed quality. Energy combination treatments did not yield any additional protection advantage. PMID:26243899

  1. Experience in using FlexCtrl SCADA for accelerator automation

    NASA Astrophysics Data System (ADS)

    Nikiforov, A.; Aleinikov, V.; Sychev, A.; Borina, I.; Rukavishnikov, A.

    2012-07-01

    The programmed component of the automatic control of accelerators on the basis of licensed software packages (FlexCtrl SCADA, Photon Application Builder, and Cogent DataHub) and an additionally developed library of classes (related to visual programming with regard to functional capabilities and which all together represent an integrated media for producing the automation system) is described in the article. The number of features of the media components and the number of the components themselves can be increased since the developed media is characterized as open.

  2. Colour stability of temporary restorations with different thicknesses submitted to artificial accelerated aging.

    PubMed

    Silame, F D J; Tonani, R; Alandia-Roman, C C; Chinelatti, M; Panzeri, H; Pires-de-Souza, F C P

    2013-12-01

    This study evaluated the colour stability of temporary prosthetic restorations with different thicknesses submitted to artificial accelerated aging. The occlusal surfaces of 40 molars were grinded to obtain flat enamel surfaces. Twenty acrylic resin specimens [Polymethyl methacrylate (Duralay) and Bis-methyl acrylate (Luxatemp)] were made with two different thicknesses, 0.5 mm and 1.0 mm. Temporary restorations were fixed on enamel and CIE L*a*b* colour parameters of each specimen were assessed before and after artificial accelerated aging. All groups showed colour alterations above the clinically acceptable limit. Luxatemp showed the lowest colour alteration regardless its thickness and Duralay showed the greatest alteration with 0.5 mm. PMID:24479216

  3. Circadian disruption induced by light-at-night accelerates aging and promotes tumorigenesis in rats

    PubMed Central

    Vinogradova, Irina A.; Anisimov, Vladimir N.; Bukalev, Andrey V.; Semenchenko, Anna V.; Zabezhinski, Mark A.

    2009-01-01

    We evaluated the effect of various light/dark regimens on the survival, life span and tumorigenesis in rats. Two hundred eight male and 203 females LIO rats were subdivided into 4 groups and kept at various light/dark regimens: standard 12:12 light/dark (LD); natural lighting of the North-West of Russia (NL); constant light (LL), and constant darkness (DD) since the age of 25 days until natural death. We found that exposure to NL and LL regimens accelerated development of metabolic syndrome and spontaneous tumorigenesis, shortened life span both in male and females rats as compared to the standard LD regimen. We conclude that circadian disruption induced by light-at-night accelerates aging and promotes tumorigenesis in rats. This observation supports the conclusion of the International Agency Research on Cancer that shift-work that involves circadian disruption is probably carcinogenic to humans. PMID:20157558

  4. Colour stability of temporary restorations with different thicknesses submitted to artificial accelerated aging.

    PubMed

    Silame, F D J; Tonani, R; Alandia-Roman, C C; Chinelatti, M; Panzeri, H; Pires-de-Souza, F C P

    2013-12-01

    This study evaluated the colour stability of temporary prosthetic restorations with different thicknesses submitted to artificial accelerated aging. The occlusal surfaces of 40 molars were grinded to obtain flat enamel surfaces. Twenty acrylic resin specimens [Polymethyl methacrylate (Duralay) and Bis-methyl acrylate (Luxatemp)] were made with two different thicknesses, 0.5 mm and 1.0 mm. Temporary restorations were fixed on enamel and CIE L*a*b* colour parameters of each specimen were assessed before and after artificial accelerated aging. All groups showed colour alterations above the clinically acceptable limit. Luxatemp showed the lowest colour alteration regardless its thickness and Duralay showed the greatest alteration with 0.5 mm.

  5. Spectroscopic measurements of plasma emission light for plasma-based acceleration experiments

    NASA Astrophysics Data System (ADS)

    Filippi, F.; Anania, M. P.; Biagioni, A.; Chiadroni, E.; Cianchi, A.; Ferrario, M.; Mostacci, A.; Palumbo, L.; Zigler, A.

    2016-09-01

    Advanced particle accelerators are based on the excitation of large amplitude plasma waves driven by either electron or laser beams. Future experiments scheduled at the SPARC_LAB test facility aim to demonstrate the acceleration of high brightness electron beams through the so-called resonant Plasma Wakefield Acceleration scheme in which a train of electron bunches (drivers) resonantly excites wakefields into a preformed hydrogen plasma; the last bunch (witness) injected at the proper accelerating phase gains energy from the wake. The quality of the accelerated beam depends strongly on plasma density and its distribution along the acceleration length. The measurements of plasma density of the order of 1016-1017 cm-3 can be performed with spectroscopic measurements of the plasma-emitted light. The measured density distribution for hydrogen filled capillary discharge with both Balmer alpha and Balmer beta lines and shot-to-shot variation are here reported.

  6. Dynamic changes of DNA epigenetic marks in mouse oocytes during natural and accelerated aging.

    PubMed

    Qian, Yan; Tu, Jiajie; Tang, Nelson Leung Sang; Kong, Grace Wing Shan; Chung, Jacqueline Pui Wah; Chan, Wai-Yee; Lee, Tin-Lap

    2015-10-01

    Aging is a complex time-dependent biological process that takes place in every cell and organ, eventually leading to degenerative changes that affect normal biological functions. In the past decades, the number of older parents has increased significantly. While it is widely recognized that oocyte aging poses higher birth and reproductive risk, the exact molecular mechanisms remain largely elusive. DNA methylation of 5-cytosine (5mC) and histone modifications are among the key epigenetic mechanisms involved in critical developmental processes and have been linked to aging. However, the impact of oocyte aging on DNA demethylation pathways has not been examined. The recent discovery of Ten-Eleven-Translocation (TET) family proteins, thymine DNA glycosylase (TDG) and the demethylation intermediates 5hmC, 5fC and 5caC has provided novel clues to delineate the molecular mechanisms in DNA demethylation. In this study, we examined the cellular level of modified cytosines (5mC, 5hmC, 5fC and 5caC) and Tet/Tdg expression in oocytes obtained from natural and accelerated oocyte aging conditions. Here we show all the DNA demethylation marks are dynamically regulated in both aging conditions, which are associated with Tet3 over-expression and Tdg repression. Such an aberrant expression pattern was more profound in accelerated aging condition. The results suggest that DNA demethylation may be actively involved in oocyte aging and have implications for development of potential drug targets to rejuvenate aging oocytes. This article is part of a Directed Issue entitled: Epigenetics dynamics in development and disease.

  7. Does cyclic stress and accelerated ageing influence the wear behavior of highly crosslinked polyethylene?

    PubMed

    Affatato, Saverio; De Mattia, Jonathan Salvatore; Bracco, Pierangiola; Pavoni, Eleonora; Taddei, Paola

    2016-06-01

    First-generation (irradiated and remelted or annealed) and second-generation (irradiated and vitamin E blended or doped) highly crosslinked polyethylenes were introduced in the last decade to solve the problems of wear and osteolysis. In this study, the influence of the Vitamin-E addition on crosslinked polyethylene (XLPE_VE) was evaluated by comparing the in vitro wear behavior of crosslinked polyethylene (XLPE) versus Vitamin-E blended polyethylene XLPE and conventional ultra-high molecular weight polyethylene (STD_PE) acetabular cups, after accelerated ageing according to ASTM F2003-02 (70.0±0.1°C, pure oxygen at 5bar for 14 days). The test was performed using a hip joint simulator run for two millions cycles, under bovine calf serum as lubricant. Mass loss was found to decrease along the series XLPE_VE>STD_PE>XLPE, although no statistically significant differences were found between the mass losses of the three sets of cups. Micro-Raman spectroscopy was used to investigate at a molecular level the morphology changes induced by wear. The spectroscopic analyses showed that the accelerated ageing determined different wear mechanisms and molecular rearrangements during testing with regards to the changes in both the chain orientation and the distribution of the all-trans sequences within the orthorhombic, amorphous and third phases. The results of the present study showed that the addition of vitamin E was not effective to improve the gravimetric wear of PE after accelerated ageing. However, from a molecular point of view, the XLPE_VE acetabular cups tested after accelerated ageing appeared definitely less damaged than the STD_PE ones and comparable to XLPE samples. PMID:26970299

  8. On the Use of Accelerated Aging Methods for Screening High Temperature Polymeric Composite Materials

    NASA Technical Reports Server (NTRS)

    Gates, Thomas S.; Grayson, Michael A.

    1999-01-01

    A rational approach to the problem of accelerated testing of high temperature polymeric composites is discussed. The methods provided are considered tools useful in the screening of new materials systems for long-term application to extreme environments that include elevated temperature, moisture, oxygen, and mechanical load. The need for reproducible mechanisms, indicator properties, and real-time data are outlined as well as the methodologies for specific aging mechanisms.

  9. Declining expression of a single epithelial cell-autonomous gene accelerates age-related thymic involution

    PubMed Central

    Sun, Liguang; Guo, Jianfei; Brown, Robert; Amagai, Takashi; Zhao, Yong; Su, Dong-Ming

    2010-01-01

    SUMMARY Age-related thymic involution may be triggered by gene expression changes in lymphohematopoietic and/or non-hematopoietic thymic epithelial cells (TECs). The role of epithelial cell-autonomous gene FoxN1 may be involved in the process, but it is still a puzzle due to shortage of evidence from gradual loss-of-function and exogenous gain-of-function studies. Using our recently generated loxP-floxed-FoxN1(fx) mouse carrying the ubiquitous CreERT (uCreERT) transgene with a low dose of spontaneous activation, which causes gradual FoxN1 deletion with age, we found that the uCreERT-fx/fx mice showed an accelerated age-related thymic involution due to progressive loss of FoxN1+ TECs. The thymic aging phenotypes were clearly observable as early as at 3–6 months of age, resembling the naturally aged (18–22-month-old) murine thymus. By intrathymically supplying aged wild-type mice with exogenous FoxN1-cDNA, thymic involution and defective peripheral CD4+ T-cell function could be partially rescued. The results support the notion that decline of a single epithelial cell-autonomous gene FoxN1 levels with age causes primary deterioration in TECs followed by impairment of the total postnatal thymic microenvironment, and potentially triggers age-related thymic involution in mice. PMID:20156205

  10. Colour stability of denture teeth submitted to different cleaning protocols and accelerated artificial aging.

    PubMed

    Freire, T S; Aguilar, F G; Garcia, L da Fonseca Roberti; Pires-de-Souza, F de Carvalho Panzeri

    2014-03-01

    Acrylic resin is widely used for artificial teeth manufacturing due to several important characteristics; however, this material do not present acceptable colour stability over the course of time. This study evaluated the effect of different cleaning protocols and accelerated artificial aging on colour stability of denture teeth made of acrylic resin. Sixty denture teeth in dark and light shades were used, and separated according to the treatment to which they were submitted. Results demonstrated that colour stability of artificial teeth is influenced by the cleaning solution and artificial aging, being dark teeth more susceptible to colour alteration than lighter ones.

  11. Laser wakefield acceleration experiments at the University of Michigan

    SciTech Connect

    Matsuoka, T.; McGuffey, C.; Horovitz, Y.; Dollar, F.; Bulanov, S. S.; Chvykov, V.; Kalintchenko, G.; Reed, S.; Rousseau, P.; Yanovsky, V.; Maksimchuk, A.; Krushelnick, K.; Huntington, C. M.; Drake, R. P.; Levin, M.; Zigler, A.

    2009-01-22

    Laser wakefield acceleration (LWFA) in a supersonic gas-jet using a self-guided laser pulse was studied by changing the laser power and electron density. The recently upgraded HERCULES laser facility equipped with wavefront correction enables a peak intensity of 8x10{sup 19} W/cm{sup 2} at laser power of 100 TW to be delivered to the gas-jet using f/10 focusing optics. We found that electron beam charge was increased significantly with an increase of the laser power from 30 TW to 80 TW and showed density threshold behavior at a fixed laser power. Betatron motion of electrons was also observed depending on laser power and electron density.

  12. Accelerator Challenges and Opportunities for Future Neutrino Experiments

    SciTech Connect

    Zisman, Michael S

    2010-12-24

    There are three types of future neutrino facilities currently under study, one based on decays of stored beta-unstable ion beams (?Beta Beams?), one based on decays of stored muon beams (?Neutrino Factory?), and one based on the decays of an intense pion beam (?Superbeam?). In this paper we discuss the challenges each design team must face and the R&D being carried out to turn those challenges into technical opportunities. A new program, the Muon Accelerator Program, has begun in the U.S. to carry out the R&D for muon-based facilities, including both the Neutrino Factory and, as its ultimate goal, a Muon Collider. The goals of this program will be briefly described.

  13. Accelerator Challenges and Opportunities for Future Neutrino Experiments

    SciTech Connect

    Zisman, Michael S.

    2011-10-06

    There are three types of future neutrino facilities currently under study, one based on decays of stored beta-unstable ion beams ('Beta Beams'), one based on decays of stored muon beams ('Neutrino Factory'), and one based on the decays of an intense pion beam ('Superbeam'). In this paper we discuss the challenges each design team must face and the R and D being carried out to turn those challenges into technical opportunities. A new program, the Muon Accelerator Program, has begun in the U.S. to carry out the R and D for muon-based facilities, including both the Neutrino Factory and, as its ultimate goal, a Muon Collider. The goals of this program will be briefly described.

  14. Operational experience from a large EPICS-based accelerator facility

    SciTech Connect

    Ciarlette, D.J.; Gerig, R.

    1995-12-31

    The Advanced Photon Source (APS) at Argonne National Laboratory is a third-generation x-ray light source which uses the Experimental Physics and Industrial Control System (EPICS) to operate its linear accelerator, positron accumulator ring, booster synchrotron, and storage ring equipment. EPICS has been used at the APS since the beginning of installation and commissioning. Currently, EPICS controls approximately 100 VME crates containing over 100,000 process variables. With this complexity, the APS has had to review some of the methods originally employed and make changes as necessary. In addition, due to commissioning and operational needs, higher-level operator software needed to be created. EPICS has been flexible enough to allow this.

  15. Monitoring migration and transformation of nanomaterials in polymeric composites during accelerated aging

    NASA Astrophysics Data System (ADS)

    Vilar, G.; Fernández-Rosas, E.; Puntes, V.; Jamier, V.; Aubouy, L.; Vázquez-Campos, S.

    2013-04-01

    The incorporation of small amounts of nanoadditives in polymeric compounds can introduce new mechanical, physical, electrical, magnetic, thermal and/or optical properties. The properties of these advanced materials have enabled new applications in several industrial sectors (electronics, automotive, textile...). In particular, for the nanomaterials (NM) described in this work, multi-walled carbon nanotubes (MWCNT) and silicon dioxide nanoparticles (SiO2 NP), the following properties have been described: MWCNT act as nucleating agents in thermoplastics, and change viscosity, affecting dispersion, orientation, and therefore mechanical, thermal, and electrical properties; and SiO2 NP act as flame retardant and display improved electrical and mechanical properties. The work described here is focused on the evaluation of the migration and transformation of NM included in polymer nanocomposites (NC) during accelerated climatic ageing. To this aim, we generated polyamide 6 (PA6) NC with different degree of compatibility between the NM and the polymeric matrix. These NC were submitted to accelerated aging conditions to simulate outdoor conditions (simulation of the use phase of the polymeric NC). The NC contain as nanofillers MWCNT and SiO2 NP with different surface properties to influence the compatibility with the polymeric matrix. The generated NC were evaluated by scanning electron microscopy (SEM), transmission electron microscopy (TEM) with Energy-dispersive X-ray spectroscopy (EDX), thermogravimetry (TGA) and differential scanning calorimetry (DSC) before and after the aging process, to monitor the compatibility of the NM with the matrix: dispersion within the matrix, migration during aging, and modification of the polymer properties. The dispersion of SiO2 NP in the NC depended on their compatibility with the matrix. However, independently of their compatibility with the matrix, SiO2 NP were aggregated at the end of the accelerated aging process. In addition

  16. Accelerated changes in white matter microstructure during aging: a longitudinal diffusion tensor imaging study.

    PubMed

    Sexton, Claire E; Walhovd, Kristine B; Storsve, Andreas B; Tamnes, Christian K; Westlye, Lars T; Johansen-Berg, Heidi; Fjell, Anders M

    2014-11-12

    It is well established that human brain white matter structure changes with aging, but the timescale and spatial distribution of this change remain uncertain. Cross-sectional diffusion tensor imaging (DTI) studies indicate that, after a period of relative stability during adulthood, there is an accelerated decline in anisotropy and increase in diffusivity values during senescence; and, spatially, results have been discussed within the context of several anatomical frameworks. However, inferring trajectories of change from cross-sectional data can be challenging; and, as yet, there have been no longitudinal reports of the timescale and spatial distribution of age-related white matter change in healthy adults across the adult lifespan. In a longitudinal DTI study of 203 adults between 20 and 84 years of age, we used tract-based spatial statistics to characterize the pattern of annual change in fractional anisotropy, axial diffusivity, radial diffusivity, and mean diffusivity and examined whether there was an acceleration of change with age. We found extensive and overlapping significant annual decreases in fractional anisotropy, and increases in axial diffusivity, radial diffusivity, and mean diffusivity. Spatially, results were consistent with inferior-to-superior gradients of lesser-to-greater vulnerability. Annual change increased with age, particularly within superior regions, with age-related decline estimated to begin in the fifth decade. Charting white matter microstructural changes in healthy aging provides essential context to clinical studies, and future studies should compare age trajectories between healthy participants and at-risk populations and also explore the relationship between DTI rates of change and cognitive decline.

  17. Tooth loss early in life accelerates age-related bone deterioration in mice.

    PubMed

    Kurahashi, Minori; Kondo, Hiroko; Iinuma, Mitsuo; Tamura, Yasuo; Chen, Huayue; Kubo, Kin-ya

    2015-01-01

    Both osteoporosis and tooth loss are health concerns that affect many older people. Osteoporosis is a common skeletal disease of the elderly, characterized by low bone mass and microstructural deterioration of bone tissue. Chronic mild stress is a risk factor for osteoporosis. Many studies showed that tooth loss induced neurological alterations through activation of a stress hormone, corticosterone, in mice. In this study, we tested the hypothesis that tooth loss early in life may accelerate age-related bone deterioration using a mouse model. Male senescence-accelerated mouse strain P8 (SAMP8) mice were randomly divided into control and toothless groups. Removal of the upper molar teeth was performed at one month of age. Bone response was evaluated at 2, 5 and 9 months of age. Tooth loss early in life caused a significant increase in circulating corticosterone level with age. Osteoblast bone formation was suppressed and osteoclast bone resorption was activated in the toothless mice. Trabecular bone volume fraction of the vertebra and femur was decreased in the toothless mice with age. The bone quality was reduced in the toothless mice at 5 and 9 months of age, compared with the age-matched control mice. These findings indicate that tooth loss early in life impairs the dynamic homeostasis of the bone formation and bone resorption, leading to reduced bone strength with age. Long-term tooth loss may have a cumulative detrimental effect on bone health. It is important to take appropriate measures to treat tooth loss in older people for preventing and/or treating senile osteoporosis.

  18. Lamin Mutations Accelerate Aging via Defective Export of Mitochondrial mRNAs through Nuclear Envelope Budding.

    PubMed

    Li, Yihang; Hassinger, Linda; Thomson, Travis; Ding, Baojin; Ashley, James; Hassinger, William; Budnik, Vivian

    2016-08-01

    Defective RNA metabolism and transport are implicated in aging and degeneration [1, 2], but the underlying mechanisms remain poorly understood. A prevalent feature of aging is mitochondrial deterioration [3]. Here, we link a novel mechanism for RNA export through nuclear envelope (NE) budding [4, 5] that requires A-type lamin, an inner nuclear membrane-associated protein, to accelerated aging observed in Drosophila LaminC (LamC) mutations. These LamC mutations were modeled after A-lamin (LMNA) mutations causing progeroid syndromes (PSs) in humans. We identified mitochondrial assembly regulatory factor (Marf), a mitochondrial fusion factor (mitofusin), as well as other transcripts required for mitochondrial integrity and function, in a screen for RNAs that exit the nucleus through NE budding. PS-modeled LamC mutations induced premature aging in adult flight muscles, including decreased levels of specific mitochondrial protein transcripts (RNA) and progressive mitochondrial degradation. PS-modeled LamC mutations also induced the accelerated appearance of other phenotypes associated with aging, including a progressive accumulation of polyubiquitin aggregates [6, 7] and myofibril disorganization [8, 9]. Consistent with these observations, the mutants had progressive jumping and flight defects. Downregulating marf alone induced the above aging defects. Nevertheless, restoring marf was insufficient for rescuing the aging phenotypes in PS-modeled LamC mutations, as other mitochondrial RNAs are affected by inhibition of NE budding. Analysis of NE budding in dominant and recessive PS-modeled LamC mutations suggests a mechanism by which abnormal lamina organization prevents the egress of these RNAs via NE budding. These studies connect defects in RNA export through NE budding to progressive loss of mitochondrial integrity and premature aging. PMID:27451905

  19. A call for virtual experiments: accelerating the scientific process.

    PubMed

    Cooper, Jonathan; Vik, Jon Olav; Waltemath, Dagmar

    2015-01-01

    Experimentation is fundamental to the scientific method, whether for exploration, description or explanation. We argue that promoting the reuse of virtual experiments (the in silico analogues of wet-lab or field experiments) would vastly improve the usefulness and relevance of computational models, encouraging critical scrutiny of models and serving as a common language between modellers and experimentalists. We review the benefits of reusable virtual experiments: in specifying, assaying, and comparing the behavioural repertoires of models; as prerequisites for reproducible research; to guide model reuse and composition; and for quality assurance in the translational application of models. A key step towards achieving this is that models and experimental protocols should be represented separately, but annotated so as to facilitate the linking of models to experiments and data. Lastly, we outline how the rigorous, streamlined confrontation between experimental datasets and candidate models would enable a "continuous integration" of biological knowledge, transforming our approach to systems biology.

  20. The influence of the accelerated ageing on the black screen element of the Electroink prints

    NASA Astrophysics Data System (ADS)

    Majnaric, I.; Bolanca, Z.; Bolanca Mirkovic, I.

    2010-06-01

    Printing material and prints undergo changes during ageing which can be recognized in deterioration in the physical, chemical and optical properties. The aim of this work is to determine the optical changes of the prints caused by ageing of the printing material and of the prints obtained by the application of the indirect electrophotography. The change of the screen elements in lighter halftone areas, which was obtained by the usage of the microscopic image analysis, has been discussed in the article. For the preparation of samples the following papers were used: fine art paper, recycled paper and offset paper as well as black Electroink. Three sample series were observed: prints on nonaged paper and ElectroInk, prints on aged paper and ElectroInk and prints on aged paper and nonaged ElectroInk. The investigation results show that by ageing of the uncoated printing substrates the decrease of the dots on prints can be expected, while the printing on the aged paper results in the increased reproduction of the halftone dots. The obtained results are the contribution to the explanation of the influence of the accelerated ageing process of papers which are used for printing and the aged prints on the halftone dot changes. Except the mentioned determined scientific contribution the results are applicable in the area of the printing product quality as well as in the forensic science.

  1. "Accelerating aging" chemotherapy on aged animals: protective effect from nutraceutical modulation.

    PubMed

    Marotta, Francesco; Harada, Masatoshi; Minelli, Emilio; Ono-Nita, Suzanne K; Marandola, Paulo

    2008-04-01

    The aim of this study was to test a novel phytocompound in an experimental model of antitumor-induced immunosuppression. Five groups of mice were considered: young (Y) and aged (A) that were given intraperitoneally 10 doses of cyclophosphamide (CPX, 25mg/kg/bw) or CPX plus (150 mg/kg/bw) of the nutraceutical DTS (Denshichi-Tochiu-Sen), and control. After sacrifice, macrophage chemotaxis and serum levels of IFN-gamma, IL-2, and GM-CSF were determined. Liver and urinary bladder were examined histologically, as were the liver and kidney for redox enzymes. CPX significantly decreased macrophage chemotaxis and all cytokines (p < 0.05, A > Y). DTS restored macrophage function and cytokine concentration (p < 0.001) and partly improved the necro-inflammatory score and substance P receptor expression in the bladder and the redox status in liver and kidney (p < 0.05). Such data suggest that DTS effectively prevents CPX-induced immune suppression and oxidative-inflammatory damage, which are particularly enhanced in aged organisms.

  2. Effect of energy density on color stability in dental resin composites under accelerated aging.

    PubMed

    Zamarripa, Eliezer; Ancona, Adriana L; D'Accorso, Norma B; Macchi, Ricardo L; Abate, Pablo F

    2008-01-01

    The effects of the energy density that is used for polymerization on properties of dental resin composites are well known. However, few studies relate color stability to this factor. The aim of this study was to assess color changes (deltaE*), in vitro, in terms of accelerated aging under UV exposure of specimens prepared with different energy densities. Four commercial dental resin composites were included in the study. Thirty six specimens were prepared for each one of them, following the procedure established by ISO 4049 Standard, and assigned to three groups: A (3.75 J/cm2), B (9 J/cm2), C (24 J/cm2). Each group was further subdivided into four subgroups: 1 (no aging), 2 (500 hours aging), 3 (1000 hours aging) and 4 (1500 hours aging). The results were analyzed by means of ANOVA and Tukey's test (alpha = 0.05) to determine the effect of the factors. Correlation was performed in order to determine the possible relationship among variables. Energy density is not a significant factor in color stability. However aging is directly proportional to color changes. deltaE* depends on filler size; hybrid material presented deltaE* of 2.1(0.5), 2.4(0.6) and 3.3(0.3) at 500, 1000 and 1500 hours of accelerated aging respectively, and nanofilled material showed deltaE* of 3.0(0.6), 4.5(1.2) and 5.9(0.6) at the same times respectively. It can be concluded that deltaE* does not depend on energy density; however other factors are involved in color change. Further studies in this area are warranted.

  3. Effects of different polishing methods on color stability of resin composites after accelerated aging.

    PubMed

    Sirin Karaarslan, Emine; Bulbul, Mehmet; Yildiz, Esma; Secilmis, Asli; Sari, Fatih; Usumez, Aslihan

    2013-01-01

    The purpose of this study was to evaluate the effect of polishing procedures on the color stability of different types of composites after aging. Forty disk-shaped specimens (Ø10×2 mm) were prepared for each composite resin type (an ormocer, a packable, a nanohybrid, and a microhybrid) for a total of 160 specimens. Each composite group was divided into four subgroups according to polishing method (n=10): control (no finishing and polishing), polishing disk, polishing wheel, and glaze material. Color parameters (L*, a*, and b*) and surface roughness were measured before and after accelerated aging. Of the polishing methods, glazed specimens showed the lowest color change (∆E*), ∆L*, and ∆b* values (p<0.05). Of the composite resins, the microhybrid composite showed the lowest ∆E* value, whereas the ormocer showed the highest (p<0.05). For all composite types, the surface roughness of their control groups decreased after aging (p<0.05). In conclusion, all composite resins showed color changes after accelerated aging, with the use of glaze material resulting in the lowest color change.

  4. Hardness evaluation of prosthetic silicones containing opacifiers following chemical disinfection and accelerated aging.

    PubMed

    Goiato, Marcelo Coelho; Haddad, Marcela Filié; Santos, Daniela Micheline dos; Pesqueira, Aldiéris Alves; Moreno, Amália

    2010-01-01

    We evaluated the effects of disinfection and aging on the hardness of silicones containing opacifiers and intended for use in facial prosthetics. A total of 90 samples were produced using a cylindrical metal mold 3 mm in height and 30 mm in diameter. The samples were fabricated from Silastic MDX 4-4210 silicone in three groups: GI contained no opacifier, GII contained barium sulfate (Ba), and GIII contained titanium dioxide (Ti). The samples were disinfected using effervescent tablets (Ef), neutral soap (Ns), or 4% chlorhexidine (Cl) 3 times a week for 60 days. After this period the samples underwent 1,008 hours of accelerated aging. The hardness was measured using a durometer immediately following the disinfection period and after 252, 504, and 1,008 hours of aging. The data were statistically analyzed using 3-way ANOVA and the Tukey test (p < .05). The GIII group exhibited the greatest variation in hardness regardless of elapsed time. All groups displayed greater hardness after 1,008 hours of accelerated aging independent of disinfectant type. All of the hardness values were within the clinically acceptable range.

  5. Dicarbonyl-induced accelerated aging in vitro in human skin fibroblasts.

    PubMed

    Sejersen, Henrik; Rattan, Suresh I S

    2009-04-01

    Dicarbonyls glyoxal (GO) and methylglyoxal (MGO) produced during the autoxidation of reducing sugars are a source of macromolecular damage in cells. Since an accumulation of damaged macromolecules is a universal characteristic of aging, we have tested whether GO and MGO which cause oxidative damage to proteins and other macromolecules can bring about accelerated aging in normal human skin fibroblasts in vitro. A treatment of cells with 1.0 mM GO or 400 microM MGO leads to the appearance of senescent phenotype within 3 days, as judged by the following criteria: morphological phenotype, irreversible growth arrest and G2 arrest, increased senescence-associated beta-galactosidase (SABG) activity, increased H2O2 level, increased Nxi-(carboxymethyl)-lysine (CML) protein level, and altered activities of superoxide dismutase and catalase antioxidant enzymes. This experimental model of accelerated cellular aging in vitro can be useful for studies on testing the effects of various physical, chemical and biological conditions, including natural and synthetic molecules, for the modulation of aging.

  6. Accelerated Aging of BKC 44306-10 Rigid Polyurethane Foam: FT-IR Spectroscopy, Dimensional Analysis, and Micro Computed Tomography

    SciTech Connect

    Gilbertson, Robert D.; Patterson, Brian M.; Smith, Zachary

    2014-01-02

    An accelerated aging study of BKC 44306-10 rigid polyurethane foam was carried out. Foam samples were aged in a nitrogen atmosphere at three different temperatures: 50 °C, 65 °C, and 80 °C. Foam samples were periodically removed from the aging canisters at 1, 3, 6, 9, 12, and 15 month intervals when FT-IR spectroscopy, dimensional analysis, and mechanical testing experiments were performed. Micro Computed Tomography imaging was also employed to study the morphology of the foams. Over the course of the aging study the foams the decreased in size by a magnitude of 0.001 inches per inch of foam. Micro CT showed the heterogeneous nature of the foam structure likely resulting from flow effects during the molding process. The effect of aging on the compression and tensile strength of the foam was minor and no cause for concern. FT-IR spectroscopy was used to follow the foam chemistry. However, it was difficult to draw definitive conclusions about the changes in chemical nature of the materials due to large variability throughout the samples.

  7. Accelerated Aging of Intervertebral Discs in a Mouse Model of Progeria

    PubMed Central

    Vo, Nam; Seo, Hyoung-Yeon; Robinson, Andria; Sowa, Gwendolyn; Bentley, Douglas; Taylor, Lauren; Studer, Rebecca; Usas, Arvydas; Huard, Johnny; Alber, Sean; Watkins, Simon C.; Lee, Joon; Coehlo, Paulo; Wang, Dong; Loppini, Mattia; Robbins, Paul D.; Niedernhofer, Laura J.; Kang, James

    2012-01-01

    Intervertebral disc degeneration (IDD) is a common and debilitating disorder that results in reduced flexibility of the spine, pain, and reduced mobility. Risk factors for IDD include age, genetic predisposition, injury, and other environmental factors such as smoking. Loss of proteoglycans (PGs) contributes to IDD with advancing age. Currently there is a lack of a model for rapid investigation of disc aging and evaluation of therapeutic interventions. Here we examined progression of disc aging in a murine model of a human progeroid syndrome caused by deficiency of the DNA repair endonuclease, ERCC1–XPF (Ercc1−/Δ mice). The ERCC1-deficient mice showed loss of disc height and degenerative structural changes in their vertebral bodies similar to those reported for old rodents. Compared to their wild-type littermates, Ercc1−/Δ mice also exhibit other age-related IDD characteristics, including premature loss of disc PG, reduced matrix PG synthesis, and enhanced apoptosis and cell senescence. Finally, the onset of age-associated disc pathologies was further accelerated in Ercc1−/Δ mice following chronic treatment with the chemotherapeutic agent mechlorethamine. These results demonstrate that Ercc1−/Δ mice represent an accurate and rapid model of disc aging and provide novel evidence that DNA damage negatively impacts PG synthesis. PMID:20973062

  8. GPU acceleration experience with RRTMG long wave radiation model

    NASA Astrophysics Data System (ADS)

    Price, Erik; Mielikainen, Jarno; Huang, Bormin; Huang, HungLung A.; Lee, Tsengdar

    2013-10-01

    in many weather forecast and climate models. RRTMG_LW is in operational use in ECMWF weather forecast system, the NCEP global forecast system, the ECHAM5 climate model, Community Earth System Model (CESM) and the weather and forecasting (WRF) model. RRTMG_LW has also been evaluated for use in GFDL climate model. In this paper, we examine the feasibility of using graphics processing units (GPUs) to accelerate the RRTMG_LW as used by the WRF. GPUs can provide a substantial improvement in RRTMG speed by supporting the parallel computation of large numbers of independent radiative calculations. Furthermore, using commodity GPUs for accelerating RRTMG_LW allows getting a much higher computational performance at lower price point than traditional CPUs. Furthermore, power and cooling costs are significantly reduced by using GPUs. A GPU-compatible version of RRTMG was implemented and thorough testing was performed to ensure that the original level of accuracy is retained. Our results show that GPUs can provide significant speedup over conventional CPUs. In particular, Nvidia's GTX 680 GPU card can provide a speedup of 69x for the compared to its single-threaded Fortran counterpart running on Intel Xeon E5-2603 CPU.

  9. Colour stability, opacity and cross-link density of composites submitted to accelerated artificial aging.

    PubMed

    Mundim, Fabrício Mariano; Pires-de-Souza, Fernanda de Carvalho Panzeri; Garcia, Lucas da Fonseca Roberti; Consani, Simonides

    2010-06-01

    The study evaluated the influence of accelerated artificial aging on colour stability, opacity and cross-link density of resin-based composites (RBCs). Seven specimens were obtained of five RBCs (Heliomolar, 4 Seasons, Tetric Evo Ceram, SR Adoro), which were submitted to colour stability and opacity analysis and cross-link density evaluation. All tests were performed before and after aging. After statistical analysis (one-way ANOVA; Tukey; p<0.05), it was observed that QuiXfil and SR Adoro presented colour alteration values above those that are clinically acceptable (deltaE=5.77 and 4.34 respectively) and the variation in opacity was lowest for SR Adoro. There was an increase in the cross-link density of all studied materials after aging.

  10. The effect of accelerated aging on color stability of denture liners.

    PubMed

    Anil, N; Hekimoglu, C; Sahin, S

    1998-09-01

    The objective of the present study was to determine the color changes resulting from the aging process in two cold and three hot curing soft liners and two hard liners. Seven samples were fabricated for each material. The initial color measurements were made with a UV-Visible Recording Spectrophotometer. The samples were then placed in an accelerated aging chamber to simulate the aging process. The color of the samples was then measured again with a colorimeter, and the color changes (delta E) were calculated. The critical mark of color change (delta E) has been quantified by the NBS. It was concluded that cold curing soft liners were not color-stable, and that hot curing soft liners and hard liners had similar color durability. These results suggest that colorants used in cold curing soft liners must be reinforced.

  11. Anticedants and natural prevention of environmental toxicants induced accelerated aging of skin.

    PubMed

    Tanuja Yadav; Mishra, Shivangi; Das, Shefali; Aggarwal, Shikha; Rani, Vibha

    2015-01-01

    Skin is frequently exposed to a variety of environmental and chemical agents that accelerate ageing. External stress such as UV radiations (UVR) and environmental pollutants majorly deteriorate the skin morphology, by activating certain intrinsic factors such as Reactive Oxygen Species (ROS) which trigger the activation of Matrix Metalloproteinases (MMPs) and inflammatory responses hence damaging the extracellular matrix (ECM) components. To counter this, an exogenous supply of anti-oxidants, is required since the endogenous anti-oxidant system cannot alone suffice the need. Bio-prospecting of natural resources for anti-oxidants has hence been intensified. Immense research is being carried out to identify potential plants with potent anti-oxidant activity against skin ageing. This review summarizes the major factors responsible for premature skin ageing and the plants being targeted to lessen the impact of those. PMID:25555260

  12. Anticedants and natural prevention of environmental toxicants induced accelerated aging of skin.

    PubMed

    Tanuja Yadav; Mishra, Shivangi; Das, Shefali; Aggarwal, Shikha; Rani, Vibha

    2015-01-01

    Skin is frequently exposed to a variety of environmental and chemical agents that accelerate ageing. External stress such as UV radiations (UVR) and environmental pollutants majorly deteriorate the skin morphology, by activating certain intrinsic factors such as Reactive Oxygen Species (ROS) which trigger the activation of Matrix Metalloproteinases (MMPs) and inflammatory responses hence damaging the extracellular matrix (ECM) components. To counter this, an exogenous supply of anti-oxidants, is required since the endogenous anti-oxidant system cannot alone suffice the need. Bio-prospecting of natural resources for anti-oxidants has hence been intensified. Immense research is being carried out to identify potential plants with potent anti-oxidant activity against skin ageing. This review summarizes the major factors responsible for premature skin ageing and the plants being targeted to lessen the impact of those.

  13. Space Experiments with Particle Accelerators (SEPAC), status review, 23 September 1980

    NASA Technical Reports Server (NTRS)

    1980-01-01

    The development responsibilities of SEPAC include: accelerator systems, diagnostic systems, power systems, dedicated experiment processor, interface unit, control panel, and all flight software. The operations of SEPAC, including automated experiments under DEP command control and SEPAC manual operations, are outlined. A diagram of the system configuration is presented.

  14. 3D Simulations for a Micron-Scale, Dielectric-Based Acceleration Experiment

    SciTech Connect

    Yoder, R. B.; Travish, G.; Xu Jin; Rosenzweig, J. B.

    2009-01-22

    An experimental program to demonstrate a dielectric, slab-symmetric accelerator structure has been underway for the past two years. These resonant devices are driven by a side-coupled 800-nm laser and can be configured to maintain the field profile necessary for synchronous acceleration and focusing of relativistic or nonrelativistic particles. We present 3D simulations of various versions of the structure geometry, including a metal-walled structure relevant to ongoing cold tests on resonant properties, and an all-dielectric structure to be constructed for a proof-of-principle acceleration experiment.

  15. Time dependent diffusive shock acceleration and its application to middle aged supernova remnants

    NASA Astrophysics Data System (ADS)

    Tang, Xiaping; Chevalier, Roger A.

    2016-06-01

    Recent gamma-ray observations show that middle aged supernova remnants (SNRs) interacting with molecular clouds (MCs) can be sources of both GeV and TeV emission. Based on the MC association, two scenarios have been proposed to explain the observed gamma-ray emission. In one, energetic cosmic ray (CR) particles escape from the SNR and then illuminate nearby MCs, producing gamma-ray emission, while the other involves direct interaction between the SNR and MC. In the direct interaction scenario, re-acceleration of pre-existing CRs in the ambient medium is investigated while particles injected from the thermal pool are neglected in view of the slow shock speeds in middle aged SNRs. However, standard diffusive shock acceleration (DSA) theory produces a steady state particle spectrum that is too flat compared to observations, which suggests that the high energy part of the observed spectrum has not yet reached a steady state. We derive a time dependent DSA solution in the test particle limit for re-acceleration of pre-existing CRs case and show that it is capable of reproducing the observed gamma-ray emission in SNRs like IC 443 and W44, in the context of a MC interaction model. We also provide a simple physical picture to understand the time dependent DSA spectrum. A spatially averaged diffusion coefficient around the SNR can be estimated through fitting the gamma-ray spectrum. The spatially averaged diffusion coefficient in middle aged SNRs like IC 443 and W44 is estimated to be ~10^(25) cm^2/s at ~ 1GeV, which is between the Bohm limit and interstellar value.

  16. Length velocity acceleration at 9 months of age in a representative birth cohort of Dutch infants.

    PubMed

    Van den Broeck, J; Brand, R; Massa, G; Herngreen, W P; Wit, J M

    2000-01-01

    According to the ICP (infancy-childhood-puberty) growth model, statural growth can be divided into three partially superimposed components assumed to represent different physiologic mechanisms. This model predicts a sudden acceleration of length velocity (LV) at the onset of the childhood component around 9 months. The existence of such an infancy-childhood growth spurt has not yet been firmly corroborated by epidemiological studies. In the present study length measurements were made at the target ages of 1, 3, 6, 9, 12, 15, 18 and 24 months in a birth cohort of 2034 infants. In order to check whether length growth showed a continuous smooth pattern, different mathematical models were fitted to the individual growth curves. The models included Count and Guo functions, 5th order polynomial and combinations of 5th order polynomial with the logarithmic term of the Count function and the square root term of the Guo function. We showed that in boys and girls there is a small but systematic lack of fit of the mathematical modeling, due to a sudden acceleration of LV around 9 months. In addition there was an increase in variation of attained length at this age. Comparison of unbalanced ANOVA models with and without addition of dummy variables for the target ages confirmed that there was an acceleration around 9 months that, if corrected for, leads to a significantly improved model fit (likelihood ratio test p < 0.0001). In absolute terms of LV, the misfit at 9 months was not greater than 0.5 cm/year on average. We conclude that the results of this study support the existence of a late infancy growth spurt. In our opinion, however, the magnitude of the phenomenon does not legitimate construction and use of discontinuous growth references such as the ICP reference.

  17. Poetry Efforts by Aged Deaf: Expression of Life Cycle Experience.

    ERIC Educational Resources Information Center

    Wax, Teena M.

    1983-01-01

    Describes a day-long Aging Awareness workshop in which a group of 12 elderly were involved in a poetry-writing exercise focusing on meaningful life change. Ramifications of this positive experience are discussed in view of the cultural/language barrier and traditional aging awareness issues such as reminiscence. (JAC)

  18. Functionality, growth and accelerated aging of tissue engineered living autologous vascular grafts.

    PubMed

    Kelm, Jens M; Emmert, Maximilian Y; Zürcher, Armin; Schmidt, Dörthe; Begus Nahrmann, Yvonne; Rudolph, Karl L; Weber, Benedikt; Brokopp, Chad E; Frauenfelder, Thomas; Leschka, Sebastian; Odermatt, Bernhard; Jenni, Rolf; Falk, Volkmar; Zünd, Gregor; Hoerstrup, Simon P

    2012-11-01

    Living autologous tissue engineered vascular-grafts (TEVGs) with growth-capacity may overcome the limitations of contemporary artificial-prostheses. However, the multi-step in vitro production of TEVGs requires extensive ex vivo cell-manipulations with unknown effects on functionality and quality of TEVGs due to an accelerated biological age of the cells. Here, the impact of biological cell-age and tissue-remodeling capacity of TEVGs in relation to their clinical long-term functionality are investigated. TEVGs were implanted as pulmonary-artery (PA) replacements in juvenile sheep and followed for up to 240 weeks (∼4.5years). Telomere length and telomerase activity were compared amongst TEVGs and adjacent native tissue. Telomerase-activity of in vitro expanded autologous vascular-cells prior to seeding was <5% as compared to a leukemic cell line, indicating biological-aging associated with decreasing telomere-length with each cellular-doubling. Up to 100 weeks, the cells in the TEVGs had consistently shorter telomeres compared to the native counterpart, whereas no significant differences were detectable at 240 weeks. Computed tomography (CT) analysis demonstrated physiological wall-pressures, shear-stresses, and flow-pattern comparable to the native PA. There were no signs of degeneration detectable and continuous native-analogous growth was confirmed by vessel-volumetry. TEVGs exhibit a higher biological age compared to their native counterparts. However, despite of this tissue engineering technology related accelerated biological-aging, growth-capacity and long-term functionality was not compromised. To the contrary, extensive in-vivo remodeling processes with substantial endogenous cellular turnover appears to result in "TEVG rejuvenation" and excellent clinical performance. As these large-animal results can be extrapolated to approximately 20 human years, this study suggests long-term clinical-safety of cardiovascular in vitro tissue engineering and may

  19. Accelerated fibrosis and apoptosis with ageing and in atrial fibrillation: Adaptive responses with maladaptive consequences

    PubMed Central

    XU, GUO-JUN; GAN, TIAN-YI; TANG, BAO-PENG; CHEN, ZU-HENG; MAHEMUTI, AILIMAN; JIANG, TAO; SONG, JIAN-GUO; GUO, XIA; LI, YAO-DONG; MIAO, HAI-JUN; ZHOU, XIAN-HUI; ZHANG, YU; LI, JIN-XIN

    2013-01-01

    The aim of this study was to investigate whether abnormal expression of matrix metalloproteinase (MMP)-9/tissue inhibitors of MMPs (TIMP)-1 and B cell lymphoma 2 (BCL-2)/BCL-2-associated X protein (BAX) are correlated with the characteristic accelerated fibrosis and apoptosis during ageing and in atrial fibrillation (AF). Four groups of dogs were studied: adult dogs in sinus rhythm (SR), aged dogs in SR, adult dogs with AF induced by rapid atrial pacing and aged dogs with AF induced by rapid atrial pacing. The mRNA and protein expression levels of the target gene in the left atrium were measured by quantitative reverse transcription-polymerase chain reaction (RT-PCR) and western blot analysis. Pathohistological and ultrastructural changes were assessed by light and electron microscopy. The apoptotic indices of myocytes were detected by terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate (dUTP) nick end labeling (TUNEL). The mRNA and protein expression levels of MMP-9 and BAX and those of TIMP-1 and BCL-2 were significantly upregulated and down-regulated, respectively, in the aged groups compared with the adult groups. Compared with the control groups, the adult and aged groups with AF exhibited significantly increased mRNA and protein expression levels of MMP-9 and BAX and decreased expression levels of TIMP-1 and BCL-2. Samples of atrial tissue demonstrated abnormal pathohistological and ultrastructural changes, accelerated fibrosis and apoptosis. MMP-9/TIMP-1 and BCL-2/BAX hold potential for use as substrates conducive to AF and their abnormal expression plays a major role in structural remodeling of the atrium. PMID:23403858

  20. Psychiatric Disorders, Morbidity, and Mortality: Tracing Mechanistic Pathways to Accelerated Aging.

    PubMed

    Kiecolt-Glaser, Janice K; Wilson, Stephanie J

    2016-09-01

    A meta-analysis published in this issue of Psychosomatic Medicine provides convincing evidence that certain psychiatric populations have shorter telomeres than nonpsychiatric controls, in accord with the strong evidence linking psychiatric disorders with premature mortality. After addressing the clinical significance of shorter telomeres, this editorial describes mechanistic pathways that lead to telomere shortening. Additionally, two other novel methods for measuring biological markers of accelerated aging are briefly discussed: DNA methylation and cellular senescence based on p16. These innovative approaches could be used to confirm and extend our understanding of psychiatric patients' increased health and mortality risks.

  1. In silico analysis of gene expression profiles in the olfactory mucosae of aging senescence-accelerated mice.

    PubMed

    Getchell, Thomas V; Peng, Xuejun; Green, C Paul; Stromberg, Arnold J; Chen, Kuey-Chu; Mattson, Mark P; Getchell, Marilyn L

    2004-08-01

    We utilized high-density Affymetrix oligonucleotide arrays to investigate gene expression in the olfactory mucosae of near age-matched aging senescence-accelerated mice (SAM). The senescence-prone (SAMP) strain has a significantly shorter lifespan than does the senescence-resistant (SAMR) strain. To analyze our data, we applied biostatistical methods that included a correlation analysis to evaluate sources of methodologic and biological variability; a two-sided t-test to identify a subpopulation of Present genes with a biologically relevant P-value <0.05; and a false discovery rate (FDR) analysis adjusted to a stringent 5% level that yielded 127 genes with a P-value of <0.001 that were differentially regulated in near age-matched SAMPs (SAMP-Os; 13.75 months) compared to SAMRs (SAMR-Os, 12.5 months). Volcano plots related the variability in the mean hybridization signals as determined by the two-sided t-test to fold changes in gene expression. The genes were categorized into the six functional groups used previously in gene profiling experiments to identify candidate genes that may be relevant for senescence at the genomic and cellular levels in the aging mouse brain (Lee et al. [2000] Nat Genet 25:294-297) and in the olfactory mucosa (Getchell et al. [2003] Ageing Res Rev 2:211-243), which serves several functions that include chemosensory detection, immune barrier function, xenobiotic metabolism, and neurogenesis. Because SAMR-Os and SAMP-Os have substantially different median lifespans, we related the rate constant alpha in the Gompertz equation on aging to intrinsic as opposed to environmental mechanisms of senescence based on our analysis of genes modulated during aging in the olfactory mucosa. PMID:15248299

  2. Holocene age of the Yuha burial: Direct radiocarbon determinations by accelerator mass spectrometry

    USGS Publications Warehouse

    Stafford, Thomas W.; Jull, A.J.T.; Zabel, T.H.; Donahue, D.J.; Duhamel, R.C.; Brendel, K.; Haynes, C.V.; Bischoff, J.L.; Payen, L.A.; Taylor, R.E.

    1984-01-01

    The view that human populations may not have arrived in the Western Hemisphere before about 12,000 radiocarbon yr BP1,2 has been challenged by claims of much greater antiquity for a small number of archaeological sites and human skeleton samples. One such site is the Homo sapiens sapiens cairn burial excavated in 1971 from the Yuha desert, Imperial County, California3-5. Radiocarbon analysis of caliche coating one of the bones of the skeleton yielded a radiocarbon age of 21,500??1,000 yr BP4, while radiocarbon and uranium series analyses of caliche coating a cairn boulder yielded ages of 22,125??400 and 19,000??3,000 yr BP, respectively5. The late Pleistocene age assignment to the Yuha burial has been challenged by comparing the cultural context of the burial with other cairn burials in the same region6, on the basis of the site's geomorphological context and from radiocarbon analyses of soil caliches. 7,8 In rebuttal, arguments in defence of the original age assignment have been presented9,10 as well as an amino acid racemization analysis on the Yuha skeleton indicating an age of 23,600??2,600 yr BP11. The tandem accelerator mass spectrometer at the University of Arizona has now been used to measure the ratio of 14C/13C in several organic and inorganic fractions of post-cranial bone from the Yuha H. sapiens sapiens skeleton. Isotope ratios from six chemical fractions all yielded radiocarbon ages for the skeleton of less than 4,000 yr BP. These results indicate that the Yuha skeleton is of Holocene age, in agreement with the cultural context of the burial, and in disagreement with the previously assigned Pleistocene age of 19,000-23,000 yr. ?? 1984 Nature Publishing Group.

  3. Evaluation of commercial ADC radiation tolerance for accelerator experiments

    SciTech Connect

    Chen, K.; Chen, H.; Kierstead, J.; Takai, H.; Rescia, S.; Hu, X.; Xu, H.; Mead, J.; Lanni, F.; Minelli, M.

    2015-08-17

    Electronic components used in high energy physics experiments are subjected to a radiation background composed of high energy hadrons, mesons and photons. These particles can induce permanent and transient effects that affect the normal device operation. Ionizing dose and displacement damage can cause chronic damage which disable the device permanently. Transient effects or single event effects are in general recoverable with time intervals that depend on the nature of the failure. The magnitude of these effects is technology dependent with feature size being one of the key parameters. Analog to digital converters are components that are frequently used in detector front end electronics, generally placed as close as possible to the sensing elements to maximize signal fidelity. We report on radiation effects tests conducted on 17 commercially available analog to digital converters and extensive single event effect measurements on specific twelve and fourteen bit ADCs that presented high tolerance to ionizing dose. We discuss mitigation strategies for single event effects (SEE) for their use in the large hadron collider environment.

  4. Evaluation of commercial ADC radiation tolerance for accelerator experiments

    DOE PAGES

    Chen, K.; Chen, H.; Kierstead, J.; Takai, H.; Rescia, S.; Hu, X.; Xu, H.; Mead, J.; Lanni, F.; Minelli, M.

    2015-08-17

    Electronic components used in high energy physics experiments are subjected to a radiation background composed of high energy hadrons, mesons and photons. These particles can induce permanent and transient effects that affect the normal device operation. Ionizing dose and displacement damage can cause chronic damage which disable the device permanently. Transient effects or single event effects are in general recoverable with time intervals that depend on the nature of the failure. The magnitude of these effects is technology dependent with feature size being one of the key parameters. Analog to digital converters are components that are frequently used in detectormore » front end electronics, generally placed as close as possible to the sensing elements to maximize signal fidelity. We report on radiation effects tests conducted on 17 commercially available analog to digital converters and extensive single event effect measurements on specific twelve and fourteen bit ADCs that presented high tolerance to ionizing dose. We discuss mitigation strategies for single event effects (SEE) for their use in the large hadron collider environment.« less

  5. Improving Bone Microarchitecture in Aging with Diosgenin Treatment: A Study in Senescence-Accelerated OXYS Rats.

    PubMed

    Tikhonova, Maria A; Ting, Che-Hao; Kolosova, Nataliya G; Hsu, Chao-Yu; Chen, Jian-Horng; Huang, Chi-Wen; Tseng, Ging-Ting; Hung, Ching-Sui; Kao, Pan-Fu; Amstislavskaya, Tamara G; Ho, Ying-Jui

    2015-10-31

    Osteoporosis is a major disease associated with aging. We have previously demonstrated that diosgenin prevents osteoporosis in both menopause and D-galactose-induced aging rats. OXYS rats reveal an accelerated senescence and are used as a suitable model of osteoporosis. The aim of the present study was to analyze microarchitecture and morphological changes in femur of OXYS rats using morphological tests and microcomputed tomography scanning, and to evaluate the effects of oral administration of diosgenin at 10 and 50 mg/kg/day on femur in OXYS rats. The result showed that, compared with age-matched Wistar rats, the femur of OXYS rats revealed lower bone length, bone weight, bone volume, frame volume, frame density, void volume, porosity, external and internal diameters, cortical bone area, BV/TV, Tb.N, and Tb.Th, but higher Tb.Sp. Eight weeks of diosgenin treatment decreased porosity and Tb.Sp, but increased BV/TV, cortical bone area, Tb.N and bone mineral density, compared with OXYS rats treated with vehicle. These data reveal that microarchitecture and morphological changes in femur of OXYS rats showed osteoporotic aging features and suggest that diosgenin may have beneficial effects on aging-induced osteoporosis. PMID:26387656

  6. The signaling pathways by which the Fas/FasL system accelerates oocyte aging

    PubMed Central

    Zhu, Jiang; Lin, Fei-Hu; Zhang, Jie; Lin, Juan; Li, Hong; Li, You-Wei; Tan, Xiu-Wen; Tan, Jing-He

    2016-01-01

    In spite of great efforts, the mechanisms for postovulatory oocyte aging are not fully understood. Although our previous work showed that the FasL/Fas signaling facilitated oocyte aging, the intra-oocyte signaling pathways are unknown. Furthermore, the mechanisms by which oxidative stress facilitates oocyte aging and the causal relationship between Ca2+ rises and caspase-3 activation and between the cell cycle and apoptosis during oocyte aging need detailed investigations. Our aim was to address these issues by studying the intra-oocyte signaling pathways for Fas/FasL to accelerate oocyte aging. The results indicated that sFasL released by cumulus cells activated Fas on the oocyte by increasing reactive oxygen species via activating NADPH oxidase. The activated Fas triggered Ca2+ release from the endoplasmic reticulum by activating phospholipase C-γ pathway and cytochrome c pathway. The cytoplasmic Ca2+ rises activated calcium/calmodulin-dependent protein kinase II (CaMKII) and caspase-3. While activated CaMKII increased oocyte susceptibility to activation by inactivating maturation-promoting factor (MPF) through cyclin B degradation, the activated caspase-3 facilitated further Ca2+ releasing that activates more caspase-3 leading to oocyte fragmentation. Furthermore, caspase-3 activation and fragmentation were prevented in oocytes with a high MPF activity, suggesting that an oocyte must be in interphase to undergo apoptosis. PMID:26869336

  7. Skeletal Involution by Age-associated Oxidative Stress and Its Acceleration by Loss of Sex Steroids*

    PubMed Central

    Almeida, Maria; Han, Li; Martin-Millan, Marta; Plotkin, Lilian I.; Stewart, Scott A.; Roberson, Paula K.; Kousteni, Stavroula; O’Brien, Charles A.; Bellido, Teresita; Parfitt, A. Michael; Weinstein, Robert S.; Jilka, Robert L.; Manolagas, Stavros C.

    2011-01-01

    Both aging and loss of sex steroids have adverse effects on skeletal homeostasis, but whether and how they may influence each others negative impact on bone remains unknown. We report herein that both female and male C57BL/6 mice progressively lost strength (as determined by load-to-failure measurements) and bone mineral density in the spine and femur between the ages of 4 and 31 months. These changes were temporally associated with decreased rate of remodeling as evidenced by decreased osteoblast and osteoclast numbers and decreased bone formation rate; as well as increased osteoblast and osteocyte apoptosis, increased reactive oxygen species levels, and decreased glutathione reductase activity and a corresponding increase in the phosphorylation of p53 and p66shc, two key components of a signaling cascade that are activated by reactive oxygen species and influences apoptosis and lifespan. Exactly the same changes in oxidative stress were acutely reproduced by gonadectomy in 5-month-old females or males and reversed by estrogens or androgens in vivo as well as in vitro.We conclude that the oxidative stress that underlies physiologic organismal aging in mice may be a pivotal pathogenetic mechanism of the age-related bone loss and strength. Loss of estrogens or androgens accelerates the effects of aging on bone by decreasing defense against oxidative stress. PMID:17623659

  8. A small scale accelerator-driven subcritical assembly demonstration experiment at LAMPF

    SciTech Connect

    Wender, S.A.

    1994-12-31

    The coupling of a neutron-producing accelerator with a sub-critical fission assembly has been proposed at Los Alamos as a method of addressing (1) the destruction of weapons-grade plutonium, (2) the reduction of nuclear waste from commercial reactors and, (3) the generation of power using the thorium/uranium cycle. A small scale experiment is described that will demonstrate many of the aspects of this accelerator-driven transmutation technology. This experiment will use the high-power proton beam from the LAMPF accelerator. Beam currents of up to 1 mA will be used to produce neutrons with a molten lead target. The target is surrounded by a molten salt and graphite moderator blanket. Fissionable material can be added to the molten salt to demonstrate plutonium burning, transmutation of commercial spent fuel and energy production from thorium. The experiment will be operated at power levels around 5 MWt.

  9. Lived Experiences of College-Age Transsexual Individuals

    ERIC Educational Resources Information Center

    Goodrich, Kristopher M.

    2012-01-01

    This article reviews the lived experiences of 4 college-age transsexual individuals. A qualitative study using grounded theory was conducted to investigate their experiences influencing their later educational persistence. Results suggested that level of discomfort, perceived social supports, level of secrecy, and academic achievement all affected…

  10. Age and Gender Differences in Adolescents' Homework Experiences

    ERIC Educational Resources Information Center

    Kackar, Hayal Z.; Shumow, Lee; Schmidt, Jennifer A.; Grzetich, Janel

    2011-01-01

    Extant data collected through the Experience Sampling Method were analyzed to describe adolescents' subjective experiences of homework. Analyses explored age and gender differences in the time adolescents spend doing homework, and the situational variations (location and companions) in adolescents' reported concentration, effort, interest,…

  11. Impact absorption of four processed soft denture liners as influenced by accelerated aging.

    PubMed

    Kawano, F; Koran, A; Nuryanti, A; Inoue, S

    1997-01-01

    The cushioning effect of soft denture liners was evaluated by using a free drop test with an accelerometer. Materials tested included SuperSoft (Coe Laboratories, Chicago, IL), Kurepeet-Dough (Kreha Chemical, Tokyo), Molteno Soft (Molten, Hiroshima, Japan), and Molloplast-B (Molloplast Regneri, Karlsruhe, Germany). All materials were found to reduce the impact force when compared to acrylic denture base resin. A 2.4-mm layer of soft denture material demonstrated good impact absorption, and Molloplast-B and Molteno had excellent impact absorption. When the soft denture liner was kept in an accelerated aging chamber for 900 hours, the damping effect recorded increased for all materials tested. Aging of all materials also affected the cushioning effect.

  12. The electrical performance of polymeric insulating materials under accelerated aging in a fog chamber

    SciTech Connect

    Gorur, R.S.; Cherney, E.A.; Hackam, R. ); Orbeck, T. )

    1988-07-01

    A comparative study of the ac (60 Hz) surface aging in a fog chamber is reported on cylindrical rod samples of high temperature vulcanized (HTV) silicone rubber and ethylene propylene diene monomer (EPDM) rubber containing various amounts of alumina trihydrate (ATH) and/or silica fillers. In low conductivity (250 ..mu..S/cm) fog, silicone rubber performed better than EPDM samples whereas in high conductivity (1000 ..mu..S/cm) fog, the order of performance was reversed. The mechanisms by which fillers impart tracking and erosion resistance to materials is discussed as influenced by the experimental conditions of the accelerated aging tests. Surface studies by ESCA (Electron Spectroscopy for Chemical Analysis) demonstrate that the hydrophobicity of silicone rubber, despite the accumulation of surface contamination, can be attributed to migration of low molecular weight polymer chains and/or mobile fluids, such as silicone oil.

  13. Sprint Accelerations to First Base Among Major League Baseball Players With Different Years of Career Experience.

    PubMed

    Coleman, A Eugene; Amonette, William E

    2015-07-01

    The purpose of this article was to compare times to first base in Major League Baseball games to determine whether running velocity decreases to the foul line and first base among players with differing years of playing experience. From 1998 to 2012, 1,185 sprint times to first base were analyzed: 469 outfielders, 601 infielders, and 115 catchers. The players were divided into differing experience categories depending on their years of service in Major League Baseball: 1-5, 6-10, 11-15, and 16-20+ years. Velocity at the foul line and first base was compared and interval accelerations were reported. Comparisons were completed by playing position, and within left- and right-handed batters. Left-handed outfielders exhibited reduced velocities at 6-10 (p = 0.04), 11-15 (p = 0.004), and 16-20 years (p < 0.001) compared with 1-5 years; there were no statistical differences in velocity at the foul line. Right-handed outfielders exhibited significantly reduced velocities at first base in 6-10 (p = 0.002) and 11-15 years (p = 0.001); they also had a reduced velocities at the foul line in 6-10 (p = 0.004) and 11-15 years (p = 0.009). Right-handed infielders had reduced velocities at first base in 11-15 years (p < 0.001). No other differences were observed within infielders at first base or the foul line. There were no differences within the compared variables for catchers. Decreases in running velocity to first base with experience are seen in outfielders but are less prominent in infielders and catchers. Although physical capabilities for sprinting may decline with age, it is possible that through repetition more experienced players perfect the skill-related component of running to first base, thus preserving speed.

  14. Sprint Accelerations to First Base Among Major League Baseball Players With Different Years of Career Experience.

    PubMed

    Coleman, A Eugene; Amonette, William E

    2015-07-01

    The purpose of this article was to compare times to first base in Major League Baseball games to determine whether running velocity decreases to the foul line and first base among players with differing years of playing experience. From 1998 to 2012, 1,185 sprint times to first base were analyzed: 469 outfielders, 601 infielders, and 115 catchers. The players were divided into differing experience categories depending on their years of service in Major League Baseball: 1-5, 6-10, 11-15, and 16-20+ years. Velocity at the foul line and first base was compared and interval accelerations were reported. Comparisons were completed by playing position, and within left- and right-handed batters. Left-handed outfielders exhibited reduced velocities at 6-10 (p = 0.04), 11-15 (p = 0.004), and 16-20 years (p < 0.001) compared with 1-5 years; there were no statistical differences in velocity at the foul line. Right-handed outfielders exhibited significantly reduced velocities at first base in 6-10 (p = 0.002) and 11-15 years (p = 0.001); they also had a reduced velocities at the foul line in 6-10 (p = 0.004) and 11-15 years (p = 0.009). Right-handed infielders had reduced velocities at first base in 11-15 years (p < 0.001). No other differences were observed within infielders at first base or the foul line. There were no differences within the compared variables for catchers. Decreases in running velocity to first base with experience are seen in outfielders but are less prominent in infielders and catchers. Although physical capabilities for sprinting may decline with age, it is possible that through repetition more experienced players perfect the skill-related component of running to first base, thus preserving speed. PMID:25353082

  15. An investigation into the effectiveness of smartphone experiments on students’ conceptual knowledge about acceleration

    NASA Astrophysics Data System (ADS)

    Mazzella, Alessandra; Testa, Italo

    2016-09-01

    This study is a first attempt to investigate effectiveness of smartphone-based activities on students’ conceptual understanding of acceleration. 143 secondary school students (15-16 years old) were involved in two types of activities: smartphone- and non-smartphone activities. The latter consisted in data logging and ‘cookbook’ activities. For the sake of comparison, all activities featured the same phenomena, i.e., the motion on an inclined plane and pendulum oscillations. A pre-post design was adopted, using open questionnaires as probes. Results show only weak statistical differences between the smartphone and non-smartphone groups. Students who followed smartphone activities were more able to design an experiment to measure acceleration and to correctly describe acceleration in a free fall motion. However, students of both groups had many difficulties in drawing acceleration vector along the trajectory of the studied motion. Results suggest that smartphone-based activities may be effective substitutes of traditional experimental settings and represent a valuable aid for teachers who want to implement laboratory activities at secondary school level. However, to achieve a deeper conceptual understanding of acceleration, some issues need to be addressed: what is the reference system of the built-in smartphone sensor; relationships between smartphone acceleration graphs and experimental setup; vector representation of the measured acceleration.

  16. An investigation into the effectiveness of smartphone experiments on students’ conceptual knowledge about acceleration

    NASA Astrophysics Data System (ADS)

    Mazzella, Alessandra; Testa, Italo

    2016-09-01

    This study is a first attempt to investigate effectiveness of smartphone-based activities on students’ conceptual understanding of acceleration. 143 secondary school students (15–16 years old) were involved in two types of activities: smartphone- and non-smartphone activities. The latter consisted in data logging and ‘cookbook’ activities. For the sake of comparison, all activities featured the same phenomena, i.e., the motion on an inclined plane and pendulum oscillations. A pre-post design was adopted, using open questionnaires as probes. Results show only weak statistical differences between the smartphone and non-smartphone groups. Students who followed smartphone activities were more able to design an experiment to measure acceleration and to correctly describe acceleration in a free fall motion. However, students of both groups had many difficulties in drawing acceleration vector along the trajectory of the studied motion. Results suggest that smartphone-based activities may be effective substitutes of traditional experimental settings and represent a valuable aid for teachers who want to implement laboratory activities at secondary school level. However, to achieve a deeper conceptual understanding of acceleration, some issues need to be addressed: what is the reference system of the built-in smartphone sensor; relationships between smartphone acceleration graphs and experimental setup; vector representation of the measured acceleration.

  17. A Model-based Prognostics Methodology for Electrolytic Capacitors Based on Electrical Overstress Accelerated Aging

    NASA Technical Reports Server (NTRS)

    Celaya, Jose; Kulkarni, Chetan; Biswas, Gautam; Saha, Sankalita; Goebel, Kai

    2011-01-01

    A remaining useful life prediction methodology for electrolytic capacitors is presented. This methodology is based on the Kalman filter framework and an empirical degradation model. Electrolytic capacitors are used in several applications ranging from power supplies on critical avionics equipment to power drivers for electro-mechanical actuators. These devices are known for their comparatively low reliability and given their criticality in electronics subsystems they are a good candidate for component level prognostics and health management. Prognostics provides a way to assess remaining useful life of a capacitor based on its current state of health and its anticipated future usage and operational conditions. We present here also, experimental results of an accelerated aging test under electrical stresses. The data obtained in this test form the basis for a remaining life prediction algorithm where a model of the degradation process is suggested. This preliminary remaining life prediction algorithm serves as a demonstration of how prognostics methodologies could be used for electrolytic capacitors. In addition, the use degradation progression data from accelerated aging, provides an avenue for validation of applications of the Kalman filter based prognostics methods typically used for remaining useful life predictions in other applications.

  18. Physical property comparison of 11 soft denture lining materials as a function of accelerated aging.

    PubMed

    Dootz, E R; Koran, A; Craig, R G

    1993-01-01

    Soft denture-lining materials are an important treatment option for patients who have chronic soreness associated with dental prostheses. Three distinctly different types of materials are generally used. These are plasticized polymers or copolymers, silicones, or polyphosphazene fluoroelastomer. The acceptance of these materials by patients and dentists is variable. The objective of this study is to compare the tensile strength, percent elongation, hardness, tear strength, and tear energy of eight plasticized polymers or copolymers, two silicones, and one polyphosphazene fluoroelastomer. Tests were run at 24 hours after specimen preparation and repeated after 900 hours of accelerated aging in a Weather-Ometer device. The data indicated a wide range of physical properties for soft denture-lining materials and showed that accelerated aging dramatically affected the physical and mechanical properties of many of the elastomers. No soft denture liner proved to be superior to all others. The data obtained should provide clinicians with useful information for selecting soft denture lining materials for patients.

  19. Macrophage Response to UHMWPE Submitted to Accelerated Ageing in Hydrogen Peroxide.

    PubMed

    Rocha, Magda F G; Mansur, Alexandra A P; Martins, Camila P S; Barbosa-Stancioli, Edel F; Mansur, Herman S

    2010-01-01

    Ultra-high molecular weight polyethylene (UHMWPE) has been the most commonly used bearing material in total joint arthroplasty. Wear and oxidation fatigue resistance of UHMWPE are regarded as two important properties to extend the longevity of knee prostheses. The present study investigated the accelerated ageing of UHMWPE in hydrogen peroxide highly oxidative chemical environment. The sliced samples of UHMWPE were oxidized in a hydrogen peroxide solution for 120 days with their total level of oxidation (Iox) characterized by Fourier Transformed Infrared Spectroscopy (FTIR). The potential inflammatory response, cell viability and biocompatibility of such oxidized UHMWPE systems were assessed by a novel biological in vitro assay based on the secretion of nitric oxide (NO) by activated murine macrophages with gamma interferon (IFN-gamma) cytokine and lipopolysaccharide (LPS). Furthermore, macrophage morphologies in contact with UHMWPE oxidized surfaces were analyzed by cell spreading-adhesion procedure using scanning electron microscopy (SEM). The results have given significant evidence that the longer the period of accelerated aging of UHMWPE the higher was the macrophage inflammatory equivalent response based on NO secretion analysis.

  20. Validation of accelerated ageing of Thales rotary Stirling cryocoolers for the estimation of MTTF

    NASA Astrophysics Data System (ADS)

    Seguineau, C.,; Cauquil, J.-M.; Martin, J.-Y.; Benschop, T.

    2016-05-01

    The cooled IR detectors are used in a wide range of applications. Most of the time, the cryocoolers are one of the components dimensioning the lifetime of the system. The current market needs tend to reliability figures higher than 15,000hrs in "standard conditions". Field returns are hardly useable mostly because of the uncertain environmental conditions of use, or the differences in user profiles. A previous paper explains how Thales Cryogenics has developed an approach based on accelerated ageing and statistical analysis [1]. The aim of the current paper is to compare results obtained on accelerated ageing on one side, and on the other side, specific field returns where the conditions of use are well known. The comparison between prediction and effective failure rate is discussed. Moreover, a specific focus is done on how some new applications of cryocoolers (continuous operation at a specific temperature) can increase the MTTF. Some assumptions are also exposed on how the failure modes, effects and criticality analysis evolves for continuous operation at a specific temperature and compared to experimental data.

  1. Bisphenol A exposure accelerated the aging process in the nematode Caenorhabditis elegans.

    PubMed

    Tan, Ling; Wang, Shunchang; Wang, Yun; He, Mei; Liu, Dahai

    2015-06-01

    Bisphenol A (BPA) is a well-known environmental estrogenic disruptor that causes adverse effects. Recent studies have found that chronic exposure to BPA is associated with a high incidence of several age-related diseases. Aging is characterized by progressive function decline, which affects quality of life. However, the effects of BPA on the aging process are largely unknown. In the present study, by using the nematode Caenorhabditis elegans as a model, we investigated the influence of BPA exposure on the aging process. The decrease in body length, fecundity, and population size and the increased egg laying defection suggested that BPA exposure resulted in fitness loss and reproduction aging in this animal. Lifetime exposure of worms to BPA shortened the lifespan in a dose-dependant manner. Moreover, prolonged BPA exposure resulted in age-related behavior degeneration and the accumulation of lipofuscin and lipid peroxide products. The expression of mitochondria-specific HSP-6 and endoplasmic reticulum (ER)-related HSP-70 exhibited hormetic decrease. The expression of ER-related HSP-4 decreased significantly while HSP-16.2 showed a dose-dependent increase. The decreased expression of GCS-1 and GST-4 implicated the reduced antioxidant ability under BPA exposure, and the increase in SOD-3 expression might be caused by elevated levels of reactive oxygen species (ROS) production. Finally, BPA exposure increased the generation of hydrogen peroxide-related ROS and superoxide anions. Our results suggest that BPA exposure resulted in an accelerated aging process in C. elegans mediated by the induction of oxidative stress.

  2. Selection Experiments in the Penna Model for Biological Aging

    NASA Astrophysics Data System (ADS)

    Medeiros, G.; Idiart, M. A.; de Almeida, R. M. C.

    We consider the Penna model for biological aging to investigate correlations between early fertility and late life survival rates in populations at equilibrium. We consider inherited initial reproduction ages together with a reproduction cost translated in a probability that mother and offspring die at birth, depending on the mother age. For convenient sets of parameters, the equilibrated populations present genetic variability in what regards both genetically programmed death age and initial reproduction age. In the asexual Penna model, a negative correlation between early life fertility and late life survival rates naturally emerges in the stationary solutions. In the sexual Penna model, selection experiments are performed where individuals are sorted by initial reproduction age from the equilibrated populations and the separated populations are evolved independently. After a transient, a negative correlation between early fertility and late age survival rates also emerges in the sense that populations that start reproducing earlier present smaller average genetically programmed death age. These effects appear due to the age structure of populations in the steady state solution of the evolution equations. We claim that the same demographic effects may be playing an important role in selection experiments in the laboratory.

  3. Modeling laser wakefield accelerator experiments with ultrafast particle-in-cell simulations in boosted frames

    SciTech Connect

    Martins, S. F.; Fonseca, R. A.; Vieira, J.; Silva, L. O.

    2010-05-15

    The development of new laser systems at the 10 Petawatt range will push laser wakefield accelerators to novel regimes, for which theoretical scalings predict the possibility to accelerate electron bunches up to tens of GeVs in meter-scale plasmas. Numerical simulations will play a crucial role in testing, probing, and optimizing the physical parameters and the setup of future experiments. Fully kinetic simulations are computationally very demanding, pushing the limits of today's supercomputers. In this paper, the recent developments in the OSIRIS framework [R. A. Fonseca et al., Lect. Notes Comput. Sci. 2331, 342 (2002)] are described, in particular the boosted frame scheme, which leads to a dramatic change in the computational resources required to model laser wakefield accelerators. Results from one-to-one modeling of the next generation of laser systems are discussed, including the confirmation of electron bunch acceleration to the energy frontier.

  4. Modeling laser wakefield accelerator experiments with ultrafast particle-in-cell simulations in boosted framesa)

    NASA Astrophysics Data System (ADS)

    Martins, S. F.; Fonseca, R. A.; Vieira, J.; Silva, L. O.; Lu, W.; Mori, W. B.

    2010-05-01

    The development of new laser systems at the 10 Petawatt range will push laser wakefield accelerators to novel regimes, for which theoretical scalings predict the possibility to accelerate electron bunches up to tens of GeVs in meter-scale plasmas. Numerical simulations will play a crucial role in testing, probing, and optimizing the physical parameters and the setup of future experiments. Fully kinetic simulations are computationally very demanding, pushing the limits of today's supercomputers. In this paper, the recent developments in the OSIRIS framework [R. A. Fonseca et al., Lect. Notes Comput. Sci. 2331, 342 (2002)] are described, in particular the boosted frame scheme, which leads to a dramatic change in the computational resources required to model laser wakefield accelerators. Results from one-to-one modeling of the next generation of laser systems are discussed, including the confirmation of electron bunch acceleration to the energy frontier.

  5. The senescence-accelerated mouse (SAM): a higher oxidative stress and age-dependent degenerative diseases model.

    PubMed

    Chiba, Yoichi; Shimada, Atsuyoshi; Kumagai, Naoko; Yoshikawa, Keisuke; Ishii, Sanae; Furukawa, Ayako; Takei, Shiro; Sakura, Masaaki; Kawamura, Noriko; Hosokawa, Masanori

    2009-04-01

    The SAM strain of mice is actually a group of related inbred strains consisting of a series of SAMP (accelerated senescence-prone) and SAMR (accelerated senescence-resistant) strains. Compared with the SAMR strains, the SAMP strains show a more accelerated senescence process, a shorter lifespan, and an earlier onset and more rapid progress of age-associated pathological phenotypes similar to human geriatric disorders. The higher oxidative stress status observed in SAMP mice is partly caused by mitochondrial dysfunction, and may be a cause of this senescence acceleration and age-dependent alterations in cell structure and function. Based on our recent observations, we discuss a possible mechanism for mitochondrial dysfunction resulting in the excessive production of reactive oxygen species, and a role for the hyperoxidative stress status in neurodegeneration in SAMP mice. These SAM strains can serve as a useful tool to understand the cellular mechanisms of age-dependent degeneration, and to develop clinical interventions. PMID:18688709

  6. Fat-specific Dicer deficiency accelerates aging and mitigates several effects of dietary restriction in mice

    PubMed Central

    Reis, Felipe C. G.; Branquinho, Jéssica L. O.; Brandão, Bruna B.; Guerra, Beatriz A.; Silva, Ismael D.; Frontini, Andrea; Thomou, Thomas; Sartini, Loris; Cinti, Saverio; Kahn, C. Ronald; Festuccia, William T.; Kowaltowski, Alicia J.; Mori, Marcelo A.

    2016-01-01

    Aging increases the risk of type 2 diabetes, and this can be prevented by dietary restriction (DR). We have previously shown that DR inhibits the downregulation of miRNAs and their processing enzymes - mainly Dicer - that occurs with aging in mouse white adipose tissue (WAT). Here we used fat-specific Dicer knockout mice (AdicerKO) to understand the contributions of adipose tissue Dicer to the metabolic effects of aging and DR. Metabolomic data uncovered a clear distinction between the serum metabolite profiles of Lox control and AdicerKO mice, with a notable elevation of branched-chain amino acids (BCAA) in AdicerKO. These profiles were associated with reduced oxidative metabolism and increased lactate in WAT of AdicerKO mice and were accompanied by structural and functional changes in mitochondria, particularly under DR. AdicerKO mice displayed increased mTORC1 activation in WAT and skeletal muscle, where Dicer expression is not affected. This was accompanied by accelerated age-associated insulin resistance and premature mortality. Moreover, DR-induced insulin sensitivity was abrogated in AdicerKO mice. This was reverted by rapamycin injection, demonstrating that insulin resistance in AdicerKO mice is caused by mTORC1 hyperactivation. Our study evidences a DR-modulated role for WAT Dicer in controlling metabolism and insulin resistance. PMID:27241713

  7. Fat-specific Dicer deficiency accelerates aging and mitigates several effects of dietary restriction in mice.

    PubMed

    Reis, Felipe C G; Branquinho, Jéssica L O; Brandão, Bruna B; Guerra, Beatriz A; Silva, Ismael D; Frontini, Andrea; Thomou, Thomas; Sartini, Loris; Cinti, Saverio; Kahn, C Ronald; Festuccia, William T; Kowaltowski, Alicia J; Mori, Marcelo A

    2016-06-01

    Aging increases the risk of type 2 diabetes, and this can be prevented by dietary restriction (DR). We have previously shown that DR inhibits the downregulation of miRNAs and their processing enzymes - mainly Dicer - that occurs with aging in mouse white adipose tissue (WAT). Here we used fat-specific Dicer knockout mice (AdicerKO) to understand the contributions of adipose tissue Dicer to the metabolic effects of aging and DR. Metabolomic data uncovered a clear distinction between the serum metabolite profiles of Lox control and AdicerKO mice, with a notable elevation of branched-chain amino acids (BCAA) in AdicerKO. These profiles were associated with reduced oxidative metabolism and increased lactate in WAT of AdicerKO mice and were accompanied by structural and functional changes in mitochondria, particularly under DR. AdicerKO mice displayed increased mTORC1 activation in WAT and skeletal muscle, where Dicer expression is not affected. This was accompanied by accelerated age-associated insulin resistance and premature mortality. Moreover, DR-induced insulin sensitivity was abrogated in AdicerKO mice. This was reverted by rapamycin injection, demonstrating that insulin resistance in AdicerKO mice is caused by mTORC1 hyperactivation. Our study evidences a DR-modulated role for WAT Dicer in controlling metabolism and insulin resistance. PMID:27241713

  8. Prognostics of Power Mosfets Under Thermal Stress Accelerated Aging Using Data-Driven and Model-Based Methodologies

    NASA Technical Reports Server (NTRS)

    Celaya, Jose; Saxena, Abhinav; Saha, Sankalita; Goebel, Kai F.

    2011-01-01

    An approach for predicting remaining useful life of power MOSFETs (metal oxide field effect transistor) devices has been developed. Power MOSFETs are semiconductor switching devices that are instrumental in electronics equipment such as those used in operation and control of modern aircraft and spacecraft. The MOSFETs examined here were aged under thermal overstress in a controlled experiment and continuous performance degradation data were collected from the accelerated aging experiment. Dieattach degradation was determined to be the primary failure mode. The collected run-to-failure data were analyzed and it was revealed that ON-state resistance increased as die-attach degraded under high thermal stresses. Results from finite element simulation analysis support the observations from the experimental data. Data-driven and model based prognostics algorithms were investigated where ON-state resistance was used as the primary precursor of failure feature. A Gaussian process regression algorithm was explored as an example for a data-driven technique and an extended Kalman filter and a particle filter were used as examples for model-based techniques. Both methods were able to provide valid results. Prognostic performance metrics were employed to evaluate and compare the algorithms.

  9. Caveolin-1 and Accelerated Host Aging in the Breast Tumor Microenvironment

    PubMed Central

    Mercier, Isabelle; Camacho, Jeanette; Titchen, Kanani; Gonzales, Donna M.; Quann, Kevin; Bryant, Kelly G.; Molchansky, Alexander; Milliman, Janet N.; Whitaker-Menezes, Diana; Sotgia, Federica; Jasmin, Jean-François; Schwarting, Roland; Pestell, Richard G.; Blagosklonny, Mikhail V.; Lisanti, Michael P.

    2013-01-01

    Increasing chronological age is the most significant risk factor for human cancer development. To examine the effects of host aging on mammary tumor growth, we used caveolin (Cav)-1 knockout mice as a bona fide model of accelerated host aging. Mammary tumor cells were orthotopically implanted into these distinct microenvironments (Cav-1+/+ versus Cav-1−/− age-matched young female mice). Mammary tumors grown in a Cav-1–deficient tumor microenvironment have an increased stromal content, with vimentin-positive myofibroblasts (a marker associated with oxidative stress) that are also positive for S6-kinase activation (a marker associated with aging). Mammary tumors grown in a Cav-1–deficient tumor microenvironment were more than fivefold larger than tumors grown in a wild-type microenvironment. Thus, a Cav-1–deficient tumor microenvironment provides a fertile soil for breast cancer tumor growth. Interestingly, the mammary tumor-promoting effects of a Cav-1–deficient microenvironment were estrogen and progesterone independent. In this context, chemoprevention was achieved by using the mammalian target of rapamycin (mTOR) inhibitor and anti-aging drug, rapamycin. Systemic rapamycin treatment of mammary tumors grown in a Cav-1–deficient microenvironment significantly inhibited their tumor growth, decreased their stromal content, and reduced the levels of both vimentin and phospho-S6 in Cav-1–deficient cancer-associated fibroblasts. Since stromal loss of Cav-1 is a marker of a lethal tumor microenvironment in breast tumors, these high-risk patients might benefit from treatment with mTOR inhibitors, such as rapamycin or other rapamycin-related compounds (rapalogues). PMID:22698676

  10. Laser-based acceleration for nuclear physics experiments at ELI-NP

    NASA Astrophysics Data System (ADS)

    Tesileanu, O.; Asavei, Th.; Dancus, I.; Gales, S.; Negoita, F.; Turcu, I. C. E.; Ursescu, D.; Zamfir, N. V.

    2016-05-01

    As part of the Extreme Light pan-European research infrastructure, Extreme Light Infrastructure - Nuclear Physics (ELI-NP) in Romania will focus on topics in Nuclear Physics, fundamental Physics and applications, based on very intense photon beams. Laser-based acceleration of electrons, protons and heavy ions is a prerequisite for a multitude of laser-driven nuclear physics experiments already proposed by the international research community. A total of six outputs of the dual-amplification chain laser system, two of 100TW, two of 1PW and two of 10PW will be employed in 5 experimental areas, with the possibility to use long and short focal lengths, gas and solid targets, reaching the whole range of laser acceleration processes. We describe the main techniques and expectations regarding the acceleration of electrons, protons and heavy nuclei at ELI-NP, and some physics cases for which these techniques play an important role in the experiments.

  11. Evaluation of oxidative behavior of polyolefin geosynthetics utilizing accelerated aging tests based on temperature and pressure

    NASA Astrophysics Data System (ADS)

    Li, Mengjia

    Polyolefin geosynthetics are susceptible to oxidation, which eventually leads to the reduction in their engineering properties. In the application of polyolefin geosynthetics, a major issue is an estimate of the materials durability (i.e. service lifetime) under various aging conditions. Antioxidant packages are added to the polyolefin products to extend the induction time, during which antioxidants are gradually depleted and polymer oxidation reactions are prevented. In this PhD study, an improved laboratory accelerating aging method under elevated and high pressure environments was applied to evaluate the combined effect of temperature and pressure on the depletion of the antioxidants and the oxidation of polymers. Four types of commercial polyolefn geosynthetic materials selected for aging tests included HDPE geogrid, polypropylene woven and nonwoven geotextiles. A total of 33 different temperature/pressure aging conditions were used, with the incubation duration up to 24 months. The applied oven temperature ranged from 35°C to 105°C and the partial oxygen pressure ranged from 0.005 MPa to 6.3 MPa. Using the Oxidative Induction Time (OIT) test, the antioxidant depletion, which is correlated to the decrease of the OIT value, was found to follow apparent first-order decay. The OIT data also showed that, the antioxidant depletion rate increased with temperature according to the Arrhenius equation, while under constant temperatures, the rate increased exponentially with the partial pressure of oxygen. A modified Arrhenius model was developed to fit the antioxidant depletion rate as a function of temperature and pressure and to predict the antioxidant lifetime under various field conditions. This study has developed new temperature/pressure incubation aging test method with lifetime prediction models. Using this new technique, the antioxidant lifetime prediction results are close to regular temperature aging data while the aging duration can be reduced considerably

  12. An Experiment in ''Less Time, More Options": A Study of Accelerated University Students.

    ERIC Educational Resources Information Center

    Litwin, James L.; And Others

    This study investigated the characteristics and experiences of 59 college students accelerated from their freshman to their junior year. The students showed high academic performance and few social problems, but questions of personal identity remained problematic; the best single predictor of academic success was found to be freshman grade-point…

  13. Using a mobile phone acceleration sensor in physics experiments on free and damped harmonic oscillations

    NASA Astrophysics Data System (ADS)

    Carlos Castro-Palacio, Juan; Velázquez-Abad, Luisberis; Giménez, Marcos H.; Monsoriu, Juan A.

    2013-06-01

    We have used a mobile phone acceleration sensor, and the Accelerometer Monitor application for Android, to collect data in physics experiments on free and damped oscillations. Results for the period, frequency, spring constant, and damping constant agree very well with measurements obtained by other methods. These widely available sensors are likely to find increased use in instructional laboratories.

  14. Recent results from polarization experiments at the LHEP-JINR Accelerator

    SciTech Connect

    Ladygin, V. P.; Azhgirey, L. S.; Gurchin, Yu. V.; Isupov, A. Yu.; Krasnov, V. A.; Khrenov, A. N.; Kiselev, A. S.; Kizka, V. A.; Kurilkin, A. K.; Kurilkin, P. K.; Livanov, A. N.; Ladygina, N. B.; Malakhov, A. I.; Piyadin, S. M.; Reznikov, S. G.; Shikhalev, M. A.; Vasiliev, T. A.; Uesaka, T.; Kawabata, T.; Sakaguchi, S.

    2008-10-13

    The review of recent results from polarization experiments performed at LHEP-JINR Accelerator Complex in a GeV range is given. The current status of the spin program at Nuclotron as well as its further continuation with new high intensity polarized deuterons ion source is discussed.

  15. The Gift of Time: Today's Academic Acceleration Case Study Voices of Experience

    ERIC Educational Resources Information Center

    Scheibel, Susan Riley

    2010-01-01

    The purpose of this qualitative case study was to examine today's academic acceleration from the lived experience and perspectives of two young adults whose education was shortened, thereby allowing them the gift of time. Through personal interviews, parent interviews, and physical artifacts, the researcher gained a complex, holistic understanding…

  16. School Counselors' Perceptions and Experience with Acceleration as a Program Option for Gifted and Talented Students

    ERIC Educational Resources Information Center

    Wood, Susannah; Portman, Tarrell Awe Agahe; Cigrand, Dawnette L.; Colangelo, Nicholas

    2010-01-01

    This article presents findings from a national survey of 149 practicing school counselors who are members of the American School Counselor Association. The survey gathered information on school counselors' perceptions of and experiences with acceleration as a program option for gifted students. Results indicate that, although school counselors'…

  17. Examining Nontraditional Graduate Students' Academic Writing Experiences in an Accelerated Adult Program

    ERIC Educational Resources Information Center

    Crite, Charles E., Jr.

    2013-01-01

    The academic writing competencies of nontraditional graduate students enrolled in accelerated graduate programs have become a growing concern for many higher learning educators in those programs. The purpose of this nonexperimental quantitative study was to examine the writing experiences that impacted nontraditional graduate students enrolled in…

  18. Measuring the Acceleration Due to Gravity: An Experiment Galileo Could Have Run.

    ERIC Educational Resources Information Center

    Mentzer, Robert G.

    1984-01-01

    Today students routinely measure the acceleration due to gravity (g) with strobes and high-speed photography. However, it is possible to measure g using equipment and reasoning available to Galileo. Such an experiment (and the equipment needed) is described. (JN)

  19. Accelerated aging of extruded dielectric power cables. Part 2; Life testing of 15 kV XLPE-insulated cables

    SciTech Connect

    Bernstein, B.S.; Thue, W.A. ); Walton, M.D.; Smith J.T. III )

    1992-04-01

    Attempts to successfully use accelerated aging tests to quantify the life of medium voltage power cables in service have been elusive. This paper describes preliminary results in which 15 kV XLPE cables were subjected to accelerated aging tests under a variety of controlled voltage stress and thermal load cycle conditions, with loss of life being calculated for each set of conditions in terms of the geometric mean time to failure (GMTF). In this paper the relative influence of voltage stress and load cycle temperature are discussed. This work is part of a broad effort that also involves studies with EPR-insulated cables, accelerated aging of cables from the same manufacturing run that are direct buried at the manufacturer's site, and also aging of these cables under normal operating conditions at four United States utilities.

  20. Formerly homeless, older women's experiences with health, housing, and aging.

    PubMed

    Waldbrook, Natalie

    2013-01-01

    The perspectives of formerly homeless, older women are absent in the academic literature on aging and homelessness. In this study, a group of formerly homeless women, aged 45 years and older were surveyed (N = 15) and interviewed (n = 11) about their experiences with health, housing, and aging. The qualitative themes to be explored include the women's perceptions of their current health, coping with low incomes, dealing with addictions to alcohol and drugs, and the importance of supportive housing and other community services. The female participants' views on adapting to home, planning for their elderly years, and views on growing older are also explored.

  1. A drug-induced accelerated senescence (DIAS) is a possibility to study aging in time lapse.

    PubMed

    Alili, Lirija; Diekmann, Johanna; Giesen, Melanie; Holtkötter, Olaf; Brenneisen, Peter

    2014-06-01

    Currently, the oxidative stress (or free radical) theory of aging is the most popular explanation of how aging occurs at the molecular level. Accordingly, a stress-induced senescence-like phenotype of human dermal fibroblasts can be induced in vitro by the exposure of human diploid fibroblasts to subcytotoxic concentrations of hydrogen peroxide. However, several biomarkers of replicative senescence e.g. cell cycle arrest and enlarged morphology are abrogated 14 days after treatment, indicating that reactive oxygen species (ROS) rather acts as a trigger for short-term senescence (1-3 days) than being responsible for the maintenance of the senescence-like phenotype. Further, DNA-damaging factors are discussed resulting in a permanent senescent cell type. To induce long-term premature senescence and to understand the molecular alterations occurring during the aging process, we analyzed mitomycin C (MMC) as an alkylating DNA-damaging agent and ROS producer. Human dermal fibroblasts (HDF), used as model for skin aging, were exposed to non-cytotoxic concentrations of MMC and analyzed for potential markers of cellular aging, for example enlarged morphology, activity of senescence-associated-ß-galactosidase, cell cycle arrest, increased ROS production and MMP1-activity, which are well-documented for HDF in replicative senescence. Our data show that mitomycin C treatment results in a drug-induced accelerated senescence (DIAS) with long-term expression of senescence markers, demonstrating that a combination of different susceptibility factors, here ROS and DNA alkylation, are necessary to induce a permanent senescent cell type.

  2. Density Changes in Plutonium Observed from Accelerated Aging using Pu-238 Enrichment

    SciTech Connect

    Chung, B W; Thompson, S R; Woods, C H; Hopkins, D J; Gourdin, W H; Ebbinghaus, B B

    2003-12-19

    Plutonium, because of its radioactive nature, ages from the ''inside out'' by means of self-irradiation damage and thus produces Frankel-type defects (vacancies and self-interstitial atoms) and defect clusters. The self-irradiation damage in Plutonium-239 occurs mainly by {alpha}-particle decay, where most of the damage comes from the U-235 recoil nucleus. The defects resulting from the residual lattice damage and helium in-growth could result in microstructural and physical property changes. Because these self-irradiation effects would normally require decades to measure, with a fraction (7.5 wt%) of Pu-238 is added to the reference plutonium alloy thus accelerating the aging process by approximately 18 times the normal rate. By monitoring the properties of the Pu-238 spiked alloy over a period of about 3.5 years, the properties of plutonium in storage can be projected for periods up to about 60 years. This paper presents density and volume changes observed from the immersion density and dilatometry measurements equivalent to aging the reference plutonium alloys to nine years.

  3. Disparity between online and offline tests in accelerated aging tests of LED lamps under electric stress.

    PubMed

    Wang, Yao; Jing, Lei; Ke, Hong-Liang; Hao, Jian; Gao, Qun; Wang, Xiao-Xun; Sun, Qiang; Xu, Zhi-Jun

    2016-09-20

    The accelerated aging tests under electric stress for one type of LED lamp are conducted, and the differences between online and offline tests of the degradation of luminous flux are studied in this paper. The transformation of the two test modes is achieved with an adjustable AC voltage stabilized power source. Experimental results show that the exponential fitting of the luminous flux degradation in online tests possesses a higher fitting degree for most lamps, and the degradation rate of the luminous flux by online tests is always lower than that by offline tests. Bayes estimation and Weibull distribution are used to calculate the failure probabilities under the accelerated voltages, and then the reliability of the lamps under rated voltage of 220 V is estimated by use of the inverse power law model. Results show that the relative error of the lifetime estimation by offline tests increases as the failure probability decreases, and it cannot be neglected when the failure probability is less than 1%. The relative errors of lifetime estimation are 7.9%, 5.8%, 4.2%, and 3.5%, at the failure probabilities of 0.1%, 1%, 5%, and 10%, respectively. PMID:27661576

  4. ACCELERATED-AGING OF SHIPPING PACKAGE O-RINGS FOR PU STORAGE

    SciTech Connect

    Hoffman, E

    2008-01-10

    The Savannah River Site (SRS) is storing surplus plutonium (Pu) materials in the K-Area Materials Storage (KAMS) facility. The Pu materials are packaged per the DOE 3013 Standard. The nested, welded 300 series stainless steel 3013 containers are transported to KAMS in Type B shipping packages and subsequently stored in the same packages. These type B shipping packages consist of double containment vessels sealed with dual O-rings. The O-ring compound is Parker Seals V0835-75, based on Viton{reg_sign} GLT fluoroelastomer. This work evaluates the performance of the V0835-75 O-rings at accelerated-aging conditions. The results will be used to develop a lifetime prediction model for O-rings in KAMS.

  5. Evaluation of Experimental Parameters in the Accelerated Aging of Closed-Cell Foam Insulation

    SciTech Connect

    Stovall, Therese K; Vanderlan, Michael; Atchley, Jerald Allen

    2012-12-01

    The thermal conductivity of many closed-cell foam insulation products changes over time as production gases diffuse out of the cell matrix and atmospheric gases diffuse into the cells. Thin slicing has been shown to be an effective means of accelerating this process in such a way as to produce meaningful results. Efforts to produce a more prescriptive version of the ASTM C1303 standard test method led to the ruggedness test described here. This test program included the aging of full size insulation specimens for time periods of five years for direct comparison to the predicted results. Experimental parameters under investigation include: slice thickness, slice origin (at the surface or from the core of the slab), thin slice stack composition, product facings, original product thickness, product density, and product type. The test protocol has been completed and this report provides a detailed evaluation of the impact of the test parameters on the accuracy of the 5-year thermal conductivity prediction.

  6. Effect of disinfection and accelerated ageing on dimensional stability and detail reproduction of a facial silicone with nanoparticles.

    PubMed

    Pesqueira, A A; Goiato, M C; Dos Santos, D M; Haddad, M F; Moreno, A

    2012-05-01

    The aim of the present study was to evaluate the effect of disinfection and accelerated ageing on the dimensional stability and detail reproduction of a facial silicone with different types of nanoparticle. A total of 60 specimens were fabricated with Silastic MDX 4-4210 silicone and they were divided into three groups: colourless and pigmented with nanoparticles (make-up powder and ceramic powder). Half of the specimens of each group were disinfected with Efferdent tablets and half with neutral soap for 60 days. Afterwards, all specimens were subjected to accelerated ageing. Both dimensional stability and detail reproduction tests were performed after specimen fabrication (initial period), after chemical disinfection, and after accelerated ageing periods (252, 504 and 1008 hours). The dimensional stability test was conducted using AutoCAD software, while detail reproduction was analysed using a stereoscope magnifying glass. Dimensional stability values were statistically evaluated by analysis of variance (ANOVA) followed by Tukey's test (p < 0.01). Detail reproduction results were compared using a score. Chemical disinfection and also accelerated ageing affected the dimensional stability of the facial silicone with statistically significant results. The silicone's detail reproduction was not affected by these two factors regardless of nanoparticle type, disinfection and accelerated ageing.

  7. Effect of disinfection and accelerated ageing on dimensional stability and detail reproduction of a facial silicone with nanoparticles.

    PubMed

    Pesqueira, A A; Goiato, M C; Dos Santos, D M; Haddad, M F; Moreno, A

    2012-05-01

    The aim of the present study was to evaluate the effect of disinfection and accelerated ageing on the dimensional stability and detail reproduction of a facial silicone with different types of nanoparticle. A total of 60 specimens were fabricated with Silastic MDX 4-4210 silicone and they were divided into three groups: colourless and pigmented with nanoparticles (make-up powder and ceramic powder). Half of the specimens of each group were disinfected with Efferdent tablets and half with neutral soap for 60 days. Afterwards, all specimens were subjected to accelerated ageing. Both dimensional stability and detail reproduction tests were performed after specimen fabrication (initial period), after chemical disinfection, and after accelerated ageing periods (252, 504 and 1008 hours). The dimensional stability test was conducted using AutoCAD software, while detail reproduction was analysed using a stereoscope magnifying glass. Dimensional stability values were statistically evaluated by analysis of variance (ANOVA) followed by Tukey's test (p < 0.01). Detail reproduction results were compared using a score. Chemical disinfection and also accelerated ageing affected the dimensional stability of the facial silicone with statistically significant results. The silicone's detail reproduction was not affected by these two factors regardless of nanoparticle type, disinfection and accelerated ageing. PMID:22428808

  8. Vibration isolation technology: Sensitivity of selected classes of experiments to residual accelerations

    NASA Technical Reports Server (NTRS)

    Alexander, J. Iwan D.

    1990-01-01

    The solution was sought of a 2-D axisymmetric moving boundary problem for the sensitivity of isothermal and nonisothermal liquid columns and the sensitivity of thermo-capillary flows to buoyancy driven convection caused by residual accelerations. The sensitivity of a variety of space experiments to residual accelerations are examined. In all the cases discussed, the sensitivity is related to the dynamic response of a fluid. In some cases the sensitivity can be defined by the magnitude of the response of the velocity field. This response may involve motion of the fluid associated with internal density gradients, or the motion of a free liquid surface. For fluids with internal density gradients, the type of acceleration to which the experiment is sensitive will depend on whether buoyancy driven convection must be small in comparison to other types of fluid motion (such as thermocapillary flow), or fluid motion must be suppressed or eliminated (such as in diffusion studies, or directional solidification experiments). The effect of the velocity on the composition and temperature field must be considered, particularly in the vicinity of the melt crystal interface. As far as the response to transient disturbances is concerned the sensitivity is determined by both the magnitude and frequency the acceleration and the characteristic momentum and solute diffusion times.

  9. [Senescence-accelerated mouse (SAM): with special reference to age-associated pathologies and their modulation].

    PubMed

    Takeda, T

    1996-07-01

    The senescence-accelerated mouse (SAM) has been under development by our research team at Kyoto University since 1970 through selective inbreeding of the AKR/J strain of mice donated by the Jackson Laboratory in 1968, based on the data of the grading score of senescence, life span, and pathologic phenotypes. At present, there are 12 lines of SAM; the 9 senescence-prone inbred strains (SAMP) include SAMP1, SAMP2, SAMP3, SAMP6, SAMP7, SAMP8, SAMP9, SAMP10 and SAMP11, and the 3 senescence-resistant inbred strains (SAMR) SAMR1, SANR4 and SAMR5. Data from survival curves, the Gompertzian function and the grading score of senescence, together with growth patterns of body weight of these SAMP and SAMR mice revealed that the characteristic feature of aging common to all SAMP mice is "accelerated senescence": early onset and irreversible advance of senescence manifested by several signs and gross lesions such as the loss of normal behavior, various skin lesions, increased lordokyphosis, etc., after a period of normal development. Routine postmortem examinations and the pathobiological features revealed by systematically designed studies have shown several pathologic phenotypes, which are often characteristic enough to differentiate among the various SAM strains: senile amyloidosis in SAMP1, -P2, -P7, -P9, -P10 and -P11, secondary amyloidosis in SAMP2 and -P6, contracted kidney in SAMP1, -P2, -P10, -P11, immunoblastic lymphoma in SAMR1 and -R4, histiocytic sarcoma in SAMR1 and -R4, ovarian cysts in SAMR1, impaired immune response in SAMP1, -P2 and -P8, hyperinflation of the lungs in SAMP1, hearing impairment in SAMP1, degenerative temporomandibular joint disease in SAMP3, senile osteoporosis in SAMP6, deficits in learning and memory in SAMP8 and -P10, emotional disorders in SAMP8 and -P10, cataracts in SAMP9, and brain atrophy in SAMP10. These are all age-associated pathologies, the incidence and severity of which increase with advancing age. The SAM model in which these

  10. A small scale accelerator driven subcritical assembly development and demonstration experiment at LAMPF

    SciTech Connect

    Wender, S. A.; Venneri, F.; Bowman, C. D.; Arthur, E. D.; Heighway, E.; Beard, C. A.; Bracht, R. R.; Buksa, J. J.; Chavez, W.; DeVolder, B. G.; Park, J. J.; Parker, R. B.; Pillai, C.; Pitcher, E.; Potter, R. C.; Reid, R. S.; Russell, G. J.; Trujillo, D. A.; Weinacht, D. J.; Wilson, W. B.

    1995-09-15

    A small scale experiment is described that will demonstrate many of the aspects of accelerator-driven transmutation technology. This experiment uses the high-power proton beam from the Los Alamos Meson Physics Facility accelerator and will be located in the Area-A experimental hall. Beam currents of up to 1 mA will be used to produce neutrons with a molten lead target. The target is surrounded by a molten salt and graphite moderator blanket. Fissionable material can be added to the molten salt to demonstrate plutonium burning or transmutation of commercial spent fuel or energy production from thorium. The experiment will be operated at power levels up to 5 MWt.

  11. A small scale accelerator driven subcritical assembly development and demonstration experiment at LAMPF

    SciTech Connect

    Wender, S.A.; Venneri, F.; Bowman, C.D.; Arthur, E.D.; Heighway, E.A.; Beard, C.A.; Bracht, R.R.; Buksa, J.J.; Chavez, W.; DeVolder, B.G.

    1994-10-01

    A small scale experiment is described that will demonstrate many of the aspects of accelerator-driven transmutation technology. This experiment uses the high-power proton beam from the Los Alamos Meson Physics Facility accelerator and will be located in the Area-A experimental hall. Beam currents of up to 1 mA will be used to produce neutrons with a molten lead target. The target is surrounded by a molten salt and graphite moderator blanket. Fissionable material can be added to the molten salt to demonstrate plutonium burning or transmutation of commercial spent fuel or energy production from thorium. The experiment will be operated at power levels up to 5 MW{sub t}.

  12. A linear accelerator in the space: The beam experiment aboard rocket

    SciTech Connect

    O'Shea, P.G.; Butler, T.A.; Lynch, M.T.; McKenna, K.F.; Pongratz, M.B.

    1990-01-01

    On July 13, 1989 the BEAM experiment Aboard Rocket (BEAR) linear accelerator was successfully launched and operated in space. The flight demonstrated that a neutral hydrogen beam could be successfully propagated in an exoatmospheric environment. The accelerator, which was the result of an extensive collaboration between Los Alamos National Laboratory and industrial partners, was designed to produce a 10 mA (equivalent), 1 MeV neutral hydrogen beam in 50 {mu}s pulses at 5 Hz. The major components were a 30 keV H{sup {minus}} injector a 1 MeV radio frequency quadrupole, two 425 Mhz RF amplifiers, a gas cell neutralizer, beam optics, vacuum system and controls. The design was strongly constrained by the need for a lightweight rugged system that would survive the rigors of launch and operate autonomously. Following the flight the accelerator was recovered and operated again on the laboratory. 6 figs., 2 tabs.

  13. STS-40 orbital acceleration research experiment flight results during a typical sleep period

    NASA Technical Reports Server (NTRS)

    Blanchard, Robert C.; Nicholson, John Y.; Ritter, James R.

    1992-01-01

    The Orbital Acceleration Research Experiment (OARE), an electrostatic accelerometer package with complete on-orbit calibration capabilities was flown aboard Shuttle on STS-40. The instrument is designed to measure and record the Shuttle aerodynamic acceleration environment from the free molecule flow regime through the rarefied flow transition into the hypersonic continuum regime. Because of its sensitivity, the OARE instrument detects aerodynamic behavior of the Shuttle while in low-earth orbit. A 2-h orbital time period on day seven of the mission, when the crew was asleep and other spacecraft activities were at a minimum, was examined. Examination of the model with the flight data shows the instrument to be sensitive to all major expected low-frequency acceleration phenomena; however, some erratic instrument bias behavior persists in two axes. In these axes, the OARE data can be made to match a comprehensive atmospheric-aerodynamic model by making bias adjustments and slight liner corrections for drift.

  14. The High-Luminosity upgrade of the LHC: Physics and Technology Challenges for the Accelerator and the Experiments

    NASA Astrophysics Data System (ADS)

    Schmidt, Burkhard

    2016-04-01

    In the second phase of the LHC physics program, the accelerator will provide an additional integrated luminosity of about 2500/fb over 10 years of operation to the general purpose detectors ATLAS and CMS. This will substantially enlarge the mass reach in the search for new particles and will also greatly extend the potential to study the properties of the Higgs boson discovered at the LHC in 2012. In order to meet the experimental challenges of unprecedented pp luminosity, the experiments will need to address the aging of the present detectors and to improve the ability to isolate and precisely measure the products of the most interesting collisions. The lectures gave an overview of the physics motivation and described the conceptual designs and the expected performance of the upgrades of the four major experiments, ALICE, ATLAS, CMS and LHCb, along with the plans to develop the appropriate experimental techniques and a brief overview of the accelerator upgrade. Only some key points of the upgrade program of the four major experiments are discussed in this report; more information can be found in the references given at the end.

  15. Age-related differences in acceleration, maximum running speed, and repeated-sprint performance in young soccer players.

    PubMed

    Mendez-Villanueva, Alberto; Buchheit, Martin; Kuitunen, Sami; Douglas, Andrew; Peltola, Esa; Bourdon, Pitre

    2011-03-01

    We investigated age-related differences in the relationships among acceleration, maximum running speed, and repeated-sprint performance in 61 highly trained young male soccer players (Under 14, n = 14; Under 16, n = 22; Under 18, n = 25). We also examined the possible influence of anthropometry (stature, body mass, fat-free mass) and biological maturation (age at peak height velocity) on performance in those three sprint-running qualities. Players were tested for 10-m sprint (acceleration), flying 20-m sprint (maximum running speed), and 10 × 30-m sprint (repeated-sprint performance) times. Correlations between acceleration, maximum running speed, and repeated-sprint performance were positive and large to almost perfect (r = 0.55-0.96), irrespective of age group. There were age-based differences both in absolute performance in the three sprint-running qualities (Under 18 > Under 16 > Under 14; P < 0.001) and when body mass and fat-free mass were statistically controlled (P < 0.05). In contrast, all between-group differences disappeared after adjustment for age at peak height velocity (P > 0.05). The large correlations among acceleration, maximum running speed, and repeated-sprint performance in all age groups, as well as the disappearance of between-group differences when adjusted for estimated biological maturity, suggest that these physical qualities in young highly trained soccer players might be considered as a general quality, which is likely to be related to qualitative adaptations that accompany maturation.

  16. Helicon Plasma Injector and Ion Cyclotron Acceleration Development in the VASIMR Experiment

    NASA Technical Reports Server (NTRS)

    Squire, Jared P.; Chang, Franklin R.; Jacobson, Verlin T.; McCaskill, Greg E.; Bengtson, Roger D.; Goulding, Richard H.

    2000-01-01

    In the Variable Specific Impulse Magnetoplasma Rocket (VASIMR) radio frequency (rf) waves both produce the plasma and then accelerate the ions. The plasma production is done by action of helicon waves. These waves are circular polarized waves in the direction of the electron gyromotion. The ion acceleration is performed by ion cyclotron resonant frequency (ICRF) acceleration. The Advanced Space Propulsion Laboratory (ASPL) is actively developing efficient helicon plasma production and ICRF acceleration. The VASIMR experimental device at the ASPL is called VX-10. It is configured to demonstrate the plasma production and acceleration at the 10kW level to support a space flight demonstration design. The VX-10 consists of three electromagnets integrated into a vacuum chamber that produce magnetic fields up to 0.5 Tesla. Magnetic field shaping is achieved by independent magnet current control and placement of the magnets. We have generated both helium and hydrogen high density (>10(exp 18) cu m) discharges with the helicon source. ICRF experiments are underway. This paper describes the VX-10 device, presents recent results and discusses future plans.

  17. Accelerated aging of solid lubricants for the W76-1 TSL : effects of polymer outgassing.

    SciTech Connect

    Dugger, Michael Thomas; Wallace, William O.; Huffman, Elizabeth M.

    2006-09-01

    The behavior of MoS{sub 2} lubricants intended for the W76-1 TSL was evaluated after 17 and 82 thermal cycles, each lasting seven days and including a low temperature of -35 C and a high temperature of 93 C, in a sealed container containing organic materials. The MoS{sub 2} was applied by tumbling with MoS{sub 2} powder and steel pins (harperized), or by spraying with a resin binder (AS Mix). Surface composition measurements indicated an uptake of carbon and silicon on the lubricant surfaces after aging. Oxidation of the MoS{sub 2} on harperized coupons, where enough MoS{sub 2} was present at the surface to result in significant Mo and S concentrations, was found to be minimal for the thermal cycles in an atmosphere of primarily nitrogen. Bare steel surfaces showed a reduction in friction for exposed coupons compared to control coupons stored in nitrogen, at least for the initial cycles of sliding until the adsorbed contaminants were worn away. Lubricated surfaces showed no more than a ten percent increase in steady-state friction coefficient after exposure. Initial coefficient of friction was up to 250 percent higher than steady-state for AS Mix films on H950 coupons after 82 thermal cycles. However, the friction coefficient exhibited by lubricated coupons was never greater than 0.25, and more often less than 0.15, even after the accelerated aging exposures.

  18. Color stability of modern composites subjected to different periods of accelerated artificial aging.

    PubMed

    Drubi-Filho, Brahim; Garcia, Lucas da Fonseca Roberti; Cruvinel, Diogo Rodrigues; Sousa, Ana Beatriz Silva; Pires-de-Souza, Fernanda de Carvalho Panzeri

    2012-01-01

    The aim of this study was to evaluate the color stability of composites subjected to different periods of accelerated artificial aging (AAA). A polytetrafluorethylene matrix (10 x 2 mm) was used to fabricate 24 test specimens of three different composites (n=8): Tetric Ceram (Ivoclar/Vivadent); Filtek P90 and Z250 (3M ESPE), shade A3. After light activation for 20 s (FlashLite 1401), polishing and initial color readout (Spectrophotometer PCB 687; BYK Gardner), the test specimens were subjected to AAA (C-UV; Comexim), in 8-h cycles: 4 h exposure to UV-B rays at 50°C and 4 h condensation at 50°C. At the end of each cycle, color readouts were taken and the test ended when the mean value of ΔE attained a level ≥3.30. Tetric Ceram presented alteration in ΔE equal to 3.33 in the first aging cycle. For Filtek P90 and Z250, two (ΔE=3.60) and four (ΔE=3.42) AAA cycles were necessary. After each cycle, there was a reduction of luminosity in all the samples (ΔL). It was concluded that a short period of AAA was sufficient to promote clinically unacceptable color alteration in composites, and that this alteration was material-dependent. PMID:23306237

  19. The effect of accelerated ageing on performance properties of addition type silicone biomaterials.

    PubMed

    Stathi, K; Tarantili, P A; Polyzois, G

    2010-05-01

    The UV-protection provided to addition type silicone elastomers by various colorants, such as conventional dry earth pigments, as well as the so called "functional or reactive" pigments, was investigated. Moreover, the effect of a UV light absorber and a silica filler was also explored. Under the experimental parameters of this work, the exposure of silicone to UV radiation resulted in some changes of the IR absorbance, thermal decomposition after 400 degrees C, T(g) and tensile properties, whereas the storage modulus of samples was not affected. The obtained spectroscopic data, as well as the results of TGA and storage modulus, were interpreted by assuming that chain scission takes place during aging, whereas the improvement of tensile strength allows the hypothesis of a post-curing process, initiated by UV radiation. Therefore, the increase of T(g) could partly be due to the above reason and, furthermore, to the contribution of a rearrangement of chain fragments within the free volume of the elastomeric material. Regarding the evaluation of various coloring agents used in this work, the obtained results show that dry pigments are more sensitive to accelerated ageing conditions in comparison with functional liquid pigments. Moreover, the hydrophobic character of silicone matrix is enhanced, with the addition of this type pigments because of the vinyl functional silanes groups present in their chemical structure. Finally, it should be noted that the incorporation of silica nanofiller did not seem to prevent the silicone elastomer from degradation upon UV irradiation, but showed a significant reinforcing effect.

  20. Color stability of modern composites subjected to different periods of accelerated artificial aging.

    PubMed

    Drubi-Filho, Brahim; Garcia, Lucas da Fonseca Roberti; Cruvinel, Diogo Rodrigues; Sousa, Ana Beatriz Silva; Pires-de-Souza, Fernanda de Carvalho Panzeri

    2012-01-01

    The aim of this study was to evaluate the color stability of composites subjected to different periods of accelerated artificial aging (AAA). A polytetrafluorethylene matrix (10 x 2 mm) was used to fabricate 24 test specimens of three different composites (n=8): Tetric Ceram (Ivoclar/Vivadent); Filtek P90 and Z250 (3M ESPE), shade A3. After light activation for 20 s (FlashLite 1401), polishing and initial color readout (Spectrophotometer PCB 687; BYK Gardner), the test specimens were subjected to AAA (C-UV; Comexim), in 8-h cycles: 4 h exposure to UV-B rays at 50°C and 4 h condensation at 50°C. At the end of each cycle, color readouts were taken and the test ended when the mean value of ΔE attained a level ≥3.30. Tetric Ceram presented alteration in ΔE equal to 3.33 in the first aging cycle. For Filtek P90 and Z250, two (ΔE=3.60) and four (ΔE=3.42) AAA cycles were necessary. After each cycle, there was a reduction of luminosity in all the samples (ΔL). It was concluded that a short period of AAA was sufficient to promote clinically unacceptable color alteration in composites, and that this alteration was material-dependent.

  1. Density Changes in Plutonium Observed from Accelerated Aging Using Pu-238 Enrichment

    SciTech Connect

    Chung, B W; Thompson, S R; Woods, C H; Hopkins, D J; Gourdin, W H; Ebbinghaus, B B

    2005-10-19

    In support of Stockpile Stewardship activities, accelerated aging tests on a plutonium alloy enriched with 7.3 atomic percentage of {sup 238}Pu is underway using dilatometry at 35, 50, and 65 C and immersion density measurements of material stored at 50 C. Changes in density are expected from radiation damage in the lattice and helium in-growth. After twenty-five equivalent years of aging, the dilatometry data shows that the alloys at 35 C have expanded in volume by 0.11% to 0.12% and have started to exhibit a near linear expansion behavior primarily caused by the helium accumulation. The average He-to-vacancy ratio from tested specimens was determined to be around 2.3. The model for the lattice damage and helium in-growth accurately represents the volume swelling at 35 C. The density converted from the dilatometry corresponds well to the decreasing density trend of reference plutonium alloys as a function of time.

  2. Density changes in plutonium observed from accelerated aging using Pu-238 enrichment

    NASA Astrophysics Data System (ADS)

    Chung, B. W.; Thompson, S. R.; Woods, C. H.; Hopkins, D. J.; Gourdin, W. H.; Ebbinghaus, B. B.

    2006-09-01

    In support of Stockpile Stewardship activities, accelerated aging tests on a plutonium alloy enriched with 7.3 at.% of 238Pu is underway using dilatometry at 35, 50, and 65 °C and immersion density measurements of materials stored at 50 °C. Changes in density are expected from radiation damage in the lattice and helium in-growth. After 25 equivalent years of aging, the dilatometry data shows that the alloys at 35 °C have expanded in volume by 0.11-0.12% and have started to exhibit a near linear expansion behavior primarily caused by the helium accumulation. The average He-to-vacancy ratio from tested specimens was determined to be around 2.55. The model for the lattice damage and helium in-growth accurately represents the volume swelling at 35 °C. The density converted from the dilatometry corresponds well to the decreasing density trend of reference plutonium alloys as a function of time.

  3. [Proteoglycan in Bruch's membrane of senescence accelerated mouse: localization and age-related changes].

    PubMed

    Takada, Y; Ohkuma, H; Ogata, N; Matsushima, M; Sugasawa, K; Uyama, M

    1994-05-01

    We demonstrated the distribution of sulfated proteoglycans in Bruch's membrane of Senescence Accelerated Mouse histochemically and ultrastructurally using cuprolinic blue in conjunction with specific enzyme treatments and nitrous acid digestion. Two kinds of proteoglycan filaments were observed in the inner and outer collagenous layers, i.e., small collagen fibril-associated filaments (11 nm in average length), and large filaments (32 nm in average length). Intermediate size filaments (25 nm in average length) were seen in the basement membranes of the retinal pigment epithelium and choriocapillaris. Chondroitinase AC treatment eliminated the staining of filaments in the collagenous layers (chondroitin sulfate). Chondroitinase ABC treatment also eliminated the staining of filaments in the collagenous layers (chondroitin sulfate and dermatan sulfate). Nitrous acid eliminated the staining of filaments in both basement membranes (heparan sulfate). Proteoglycans containing chondroitin sulfate and dermatan sulfate were associated uniquely with collagen fibrils. Heparan sulfate proteoglycans were associated with the basement membranes of the pigment epithelium and choriocapillaris. With aging, the thickness of the basement membrane of the choriocapillaris and the staining of the filaments in the basement membranes of the pigment epithelium and choriocapillaris (heparan sulfate proteoglycans) increased. Collagen fibers became disarranged and the staining of both filaments in the collagenous layers decreased. The results of the staining characteristics probably reflect the aging of Bruch's membrane.

  4. Accelerating neuronal aging in in vitro model brain disorders: a focus on reactive oxygen species

    PubMed Central

    Campos, Priscila Britto; Paulsen, Bruna S.; Rehen, Stevens K.

    2014-01-01

    In this review, we discuss insights gained through the use of stem cell preparations regarding the modeling of neurological diseases, the need for aging neurons derived from pluripotent stem cells to further advance the study of late-onset adult neurological diseases, and the extent to which mechanisms linked to the mismanagement of reactive oxygen species (ROS). The context of these issues can be revealed using the three disease states of Parkinson’s (PD), Alzheimer’s (AD), and schizophrenia, as considerable insights have been gained into these conditions through the use of stem cells in terms of disease etiologies and the role of oxidative stress. The latter subject is a primary area of interest of our group. After discussing the molecular models of accelerated aging, we highlight the role of ROS for the three diseases explored here. Importantly, we do not seek to provide an extensive account of all genetic mutations for each of the three disorders discussed in this review, but we aim instead to provide a conceptual framework that could maximize the gains from merging the approaches of stem cell microsystems and the study of oxidative stress in disease in order to optimize therapeutics and determine new molecular targets against oxidative stress that spare stem cell proliferation and development. PMID:25386139

  5. A higher oxidative status accelerates senescence and aggravates age-dependent disorders in SAMP strains of mice.

    PubMed

    Hosokawa, Masanori

    2002-11-01

    The SAM strain of mice is actually a group of related inbred strains consisting of series of SAMP (accelerated senescence-prone, short-lived) and SAMR (accelerated senescence-resistant, longer-lived) strains. Comparing with the SAMR strains, the SAMP strains of mice show a more accelerated senescence process, shorter lifespan, and an earlier onset and more rapid progress of age-associated pathological phenotypes similar to several geriatric disorders observed in humans, including senile osteoporosis, degenerative joint disease, age-related deficits in learning and memory, olfactory bulb and forebrain atrophy, presbycusis and retinal atrophy, senile amyloidosis, immunosenescence, senile lungs, and diffuse medial thickening of the aorta. The higher oxidative stress observed in the SAMP strains of mice are partly caused by mitochondrial dysfunction, and may be one cause of the senescence acceleration and age-dependent alterations in cell structure and function, including neuronal cell degeneration. This senescence acceleration is also observed during senescence/crisis in cultures of isolated fibroblast-like cells from SAMP strains of mice, and was associated with a hyperoxidative status. These observations suggest that the SAM strains are useful tools in the attempt to understand the mechanisms of age-dependent degeneration of cells and tissues, and their aggravation, and to develop clinical interventions. PMID:12470893

  6. Circadian disruption induced by light-at-night accelerates aging and promotes tumorigenesis in young but not in old rats

    PubMed Central

    Vinogradova, Irina A.; Anisimov, Vladimir N.; Bukalev, Andrey V.; Ilyukha, Viktor A.; Khizhkin, Evgeniy A.; Lotosh, Tatiana A.; Semenchenko, Anna V.; Zabezhinski, Mark A.

    2010-01-01

    We evaluated the effect of exposure to constant light started at the age of 1 month and at the age of 14 months on the survival, life span, tumorigenesis and age-related dynamics of antioxidant enzymes activity in various organs in comparison to the rats maintained at the standard (12:12 light/dark) light/dark regimen. We found that exposure to constant light started at the age of 1 month accelerated spontaneous tumorigenesis and shortened life span both in male and female rats as compared to the standard regimen. At the same time, the exposure to constant light started at the age of 14 months failed to influence survival of male and female rats. While delaying tumors in males, constant light accelerated tumors in females. We conclude that circadian disruption induced by light-at-night started at the age of 1 month accelerates aging and promotes tumorigenesis in rats, however failed affect survival when started at the age of 14 months. PMID:20354269

  7. Motivation for proposed experimentation in the realm of accelerated E. M. systems: A preliminary design for an experiment

    NASA Technical Reports Server (NTRS)

    Post, E. J.

    1970-01-01

    An experiment, designed to determine the difference between fields-magnetic and electric-surrounding a uniformly moving charge as contrasted with the fields surrounding an accelerated charge, is presented. A thought experiment is presented to illustrate the process.

  8. Aging as accelerated accumulation of somatic variants: whole-genome sequencing of centenarian and middle-aged monozygotic twin pairs.

    PubMed

    Ye, Kai; Beekman, Marian; Lameijer, Eric-Wubbo; Zhang, Yanju; Moed, Matthijs H; van den Akker, Erik B; Deelen, Joris; Houwing-Duistermaat, Jeanine J; Kremer, Dennis; Anvar, Seyed Yahya; Laros, Jeroen F J; Jones, David; Raine, Keiran; Blackburne, Ben; Potluri, Shobha; Long, Quan; Guryev, Victor; van der Breggen, Ruud; Westendorp, Rudi G J; 't Hoen, Peter A C; den Dunnen, Johan; van Ommen, Gert Jan B; Willemsen, Gonneke; Pitts, Steven J; Cox, David R; Ning, Zemin; Boomsma, Dorret I; Slagboom, P Eline

    2013-12-01

    It has been postulated that aging is the consequence of an accelerated accumulation of somatic DNA mutations and that subsequent errors in the primary structure of proteins ultimately reach levels sufficient to affect organismal functions. The technical limitations of detecting somatic changes and the lack of insight about the minimum level of erroneous proteins to cause an error catastrophe hampered any firm conclusions on these theories. In this study, we sequenced the whole genome of DNA in whole blood of two pairs of monozygotic (MZ) twins, 40 and 100 years old, by two independent next-generation sequencing (NGS) platforms (Illumina and Complete Genomics). Potentially discordant single-base substitutions supported by both platforms were validated extensively by Sanger, Roche 454, and Ion Torrent sequencing. We demonstrate that the genomes of the two twin pairs are germ-line identical between co-twins, and that the genomes of the 100-year-old MZ twins are discerned by eight confirmed somatic single-base substitutions, five of which are within introns. Putative somatic variation between the 40-year-old twins was not confirmed in the validation phase. We conclude from this systematic effort that by using two independent NGS platforms, somatic single nucleotide substitutions can be detected, and that a century of life did not result in a large number of detectable somatic mutations in blood. The low number of somatic variants observed by using two NGS platforms might provide a framework for detecting disease-related somatic variants in phenotypically discordant MZ twins. PMID:24182360

  9. Recent Developments on ALICE (Accelerators and Lasers In Combined Experiments) at Daresbury Laboratory

    SciTech Connect

    Saveliev, Y M; Buckley, R K; Buckley, S R; Clarke, J A; Corlett, P A; Dunning, D J; Goulden, A R; Hill, S F; Jackson, F; Jamison, S P; Jones, J K; Jones, L B; Leonard, S; McIntosh, P A; McKenzie, J W; Middleman, K J; Militsyn, B L; Moss, A J; Muratori, B D; Orrett, J F; Pattalwar, S M; Phillips, P J; Scott, D J; Seddon, E A; Shepherd, B.J.A.; Smith, S L; Thompson, N; Wheelhouse, A E; Williams, P H; Harrison, P; Holder, D J; Holder, G M; Schofield, A L; Weightman, P; Williams, R L; Laundry, D; Powers, T; Priebe, G; Surman, M

    2010-05-01

    Progress made in ALICE (Accelerators and Lasers In Combined Experiments) commissioning and a summary of the latest experimental results are presented in this paper. After an extensive work on beam loading effects in SC RF linac (booster) and linac cavities conditioning, ALICE can now operate in full energy recovery mode at the bunch charge of 40pC, the beam energy of 30MeV and train lengths of up to 100us. This improved operation of the machine resulted in generation of coherently enhanced broadband THz radiation with the energy of several tens of uJ per pulse and in successful demonstration of the Compton Backscattering x-ray source experiment. The next steps in the ALICE scientific programme are commissioning of the IR FEL and start of the research on the first non-scaling FFAG accelerator EMMA. Results from both projects will be also reported.

  10. Rapid acceleration leads to rapid weakening in earthquake-like laboratory experiments.

    PubMed

    Chang, J C; Lockner, D A; Reches, Z

    2012-10-01

    After nucleation, a large earthquake propagates as an expanding rupture front along a fault. This front activates countless fault patches that slip by consuming energy stored in Earth's crust. We simulated the slip of a fault patch by rapidly loading an experimental fault with energy stored in a spinning flywheel. The spontaneous evolution of strength, acceleration, and velocity indicates that our experiments are proxies of fault-patch behavior during earthquakes of moment magnitude (M(w)) = 4 to 8. We show that seismically determined earthquake parameters (e.g., displacement, velocity, magnitude, or fracture energy) can be used to estimate the intensity of the energy release during an earthquake. Our experiments further indicate that high acceleration imposed by the earthquake's rupture front quickens dynamic weakening by intense wear of the fault zone. PMID:23042892

  11. Rapid acceleration leads to rapid weakening in earthquake-like laboratory experiments

    USGS Publications Warehouse

    Chang, Jefferson C.; Lockner, David A.; Reches, Z.

    2012-01-01

    After nucleation, a large earthquake propagates as an expanding rupture front along a fault. This front activates countless fault patches that slip by consuming energy stored in Earth’s crust. We simulated the slip of a fault patch by rapidly loading an experimental fault with energy stored in a spinning flywheel. The spontaneous evolution of strength, acceleration, and velocity indicates that our experiments are proxies of fault-patch behavior during earthquakes of moment magnitude (Mw) = 4 to 8. We show that seismically determined earthquake parameters (e.g., displacement, velocity, magnitude, or fracture energy) can be used to estimate the intensity of the energy release during an earthquake. Our experiments further indicate that high acceleration imposed by the earthquake’s rupture front quickens dynamic weakening by intense wear of the fault zone.

  12. Ion Acceleration by Beating Electrostatic Waves: Theory, Experiments and Relevance to Spacecraft Propulsion

    NASA Astrophysics Data System (ADS)

    Choueiri, Edgar

    2007-10-01

    After a brief overview of electrodeless plasma propulsion concepts, we will focus on a recently discovered ion acceleration mechanism, which appears to occur naturally in Earth's ionosphere, holds promise as an effective means to energize ions for applications in thermonuclear fusion and electrodeless space plasma propulsion. Unlike previously known mechanisms for energizing plasmas with electrostatic (ES) waves, and which accelerate only ions whose initial velocities are above a certain threshold (close to the wave's phase velocity), the new acceleration mechanism, involving pairs of beating ES waves, is non-resonant and can accelerate ions with arbitrarily small initial velocities, thus offering a more effective way to couple energy to plasmas. We will discuss the fundamentals of the nonlinear dynamics of a single magnetized ion interacting with a pair of beating ES waves and show that there exist necessary and sufficient conditions for the phenomenon to occur. We will see how these fundamental conditions are derived by analyzing the motion's Hamiltonian using a second-order perturbation technique in conjunction with Lie transformations. The analysis shows that when the Hamiltonian lies outside the energy barrier defined by the location of the elliptic and hyperbolic critical points of the motion, the electric field of the beating waves can accelerate ions regularly from low initial velocities, then stochastically, to high energies. We will then illustrate real plasma effects using Monte Carlo numerical simulation and discuss the recent results from a dedicated experiment in my lab in which laser-induced fluorescence (LIF) measurements of ion energies have provided the first laboratory observation of this acceleration mechanism. The talk will conclude with a few ideas on how the fundamental insight can be applied to develop novel plasma propulsion concepts.

  13. Aging assessment of reactor instrumentation and protection system components. Aging-related operating experiences

    SciTech Connect

    Gehl, A.C.; Hagen, E.W.

    1992-07-01

    A study of the aging-related operating experiences throughout a five-year period (1984--1988) of six generic instrumentation modules (indicators, sensors, controllers, transmitters, annunciators, and recorders) was performed as a part of the Nuclear Plant Aging Research Program. The effects of aging from operational and environmental stressors were characterized from results depicted in Licensee Event Reports (LERs). The data are graphically displayed as frequency of events per plant year for operating plant ages from 1 to 28 years to determine aging-related failure trend patterns. Three main conclusions were drawn from this study: (1) Instrumentation and control (I&C) modules make a modest contribution to safety-significant events: 17% of LERs issued during 1984--1988 dealt with malfunctions of the six I&C modules studied, and 28% of the LERs dealing with these I&C module malfunctions were aging related (other studies show a range 25--50%); (2) Of the six modules studied, indicators, sensors, and controllers account for the bulk (83%) of aging-related failures; and (3) Infant mortality appears to be the dominant aging-related failure mode for most I&C module categories (with the exception of annunciators and recorders, which appear to fail randomly).

  14. Preliminary Results from the UCLA/SLAC Ultra-High Gradient CerenkovWakefield Accelerator Experiment

    SciTech Connect

    Thompson, M.C.; Badakov, H.; Rosenzweig, J.B.; Travish, G.; Hogan, M.; Ischebeck, R.; Kirby, N.; Siemann, R.; Walz, D.; Muggli, P.; Scott, A.; Yoder, R.; /Manhattan Coll., Riverdale

    2008-02-06

    The first phase of an experiment to study the performance of dielectric Cerenkov wakefield accelerating structures at extremely high gradients in the GV/m range has been completed. This experiment takes advantage of the unique SLAC FFTB electron beam and its demonstrated ultra-short pulse lengths and high currents (e.g., {sigma}{sub z} = 20 {micro}m at Q = 3 nC). The FFTB electron beam has been successfully focused down and sent through varying lengths of fused silica capillary tubing with two different sizes: ID = 200 {micro}m/OD = 325 {micro}m and ID = 100 {micro}m/OD = 325 {micro}m. The pulse length of the electron beam was varied in the range 20 {micro}m < {sigma}{sub z} < 100 {micro}m which produced a range of electric fields between 2 and 20 GV/m at the inner surface of the dielectric tubes. We observed a sharp increase in optical emissions from the capillaries in the middle part of this surface field range which we believe indicates the transition between sustainable field levels and breakdown. If this initial interpretation is correct, the surfaced fields that were sustained equate to on axis accelerating field of several GV/m. In future experiments we plan to collect and measure coherent Cerenkov radiation emitted from the capillary tube to gain more information about the strength of the accelerating fields.

  15. Accelerated ageing of an EAF black slag by carbonation and percolation for long-term behaviour assessment.

    PubMed

    Gurtubay, L; Gallastegui, G; Elias, A; Rojo, N; Barona, A

    2014-07-01

    The efficient reuse of industrial by-products, such as the electric arc furnace (EAF) black slag, is still hindered by concern over their long-term behaviour in outdoor environments. The aim of this study was to develop an accelerated ageing method to simulate the long-term natural carbonation of EAF slag exposed to the elements. The degree of carbonation achieved in a freshly produced slag after accelerated ageing and in a slag used on a fifteen-year-old unpaved road was very similar. The influence of particle size on accelerated carbonation was assessed, with it being concluded that the slag sample with a particle size bigger than 5-6 mm underwent slight carbonation over time when it was exposed to CO2. The accelerated ageing procedure based on percolating a previously carbonated water solution through the slag column allowed gradual leaching with simulated acid rain, as well as providing information about the gradual and total chemical release from the slag. Three classification groups were established according to the release rate of the determined elements. The joint use of the accelerated carbonation method and the percolation test is proposed as a useful tool for environmental risk assessment concerning the long-term air exposure of EAF black slag.

  16. DeltaNp63alpha overexpression induces downregulation of Sirt1 and an accelerated aging phenotype in the mouse.

    PubMed

    Sommer, Matthias; Poliak, Nina; Upadhyay, Sunil; Ratovitski, Edward; Nelkin, Barry D; Donehower, Lawrence A; Sidransky, David

    2006-09-01

    p63 is highly expressed in the skin and appears to be an early marker of keratinocyte differentiation. To examine the role of p63 in vivo, we generated transgenic mice that overexpress deltaNp63alpha in the skin. These mice exhibited an accelerated aging phenotype in the skin characterized by striking wound healing defects, decreased skin thickness, decreased subcutaneous fat tissue, hair loss, and decreased cell proliferation. The accelerated skin aging was accompanied by a dramatic decrease in longevity of the mice. We found that aging in deltaNp63alpha transgenic mice and other mouse models correlated with levels of Sirt1, a mammalian SIR2 orthologue thought to extend the lifespan in lower species. Moreover, increased deltaNp63alpha expression induced cellular senescence that was rescued by Sirt1. Our data suggest that deltaNp63alpha levels may affect aging in mammals, at least in part, through regulation of Sirt1.

  17. Accelerating the connection between experiments and models: The FACE-MDS experience

    NASA Astrophysics Data System (ADS)

    Norby, R. J.; Medlyn, B. E.; De Kauwe, M. G.; Zaehle, S.; Walker, A. P.

    2014-12-01

    The mandate is clear for improving communication between models and experiments to better evaluate terrestrial responses to atmospheric and climatic change. Unfortunately, progress in linking experimental and modeling approaches has been slow and sometimes frustrating. Recent successes in linking results from the Duke and Oak Ridge free-air CO2 enrichment (FACE) experiments with ecosystem and land surface models - the FACE Model-Data Synthesis (FACE-MDS) project - came only after a period of slow progress, but the experience points the way to future model-experiment interactions. As the FACE experiments were approaching their termination, the FACE research community made an explicit attempt to work together with the modeling community to synthesize and deliver experimental data to benchmark models and to use models to supply appropriate context for the experimental results. Initial problems that impeded progress were: measurement protocols were not consistent across different experiments; data were not well organized for model input; and parameterizing and spinning up models that were not designed for simulating a specific site was difficult. Once these problems were worked out, the FACE-MDS project has been very successful in using data from the Duke and ORNL FACE experiment to test critical assumptions in the models. The project showed, for example, that the stomatal conductance model most widely used in models was supported by experimental data, but models did not capture important responses such as increased leaf mass per unit area in elevated CO2, and did not appropriately represent foliar nitrogen allocation. We now have an opportunity to learn from this experience. New FACE experiments that have recently been initiated, or are about to be initiated, include a eucalyptus forest in Australia; the AmazonFACE experiment in a primary, tropical forest in Brazil; and a mature oak woodland in England. Cross-site science questions are being developed that will have a

  18. Towards Prognostics of Power MOSFETs: Accelerated Aging and Precursors of Failure

    NASA Technical Reports Server (NTRS)

    Celaya, Jose R.; Saxena, Abhinav; Wysocki, Philip; Saha, Sankalita; Goebel, Kai

    2010-01-01

    This paper presents research results dealing with power MOSFETs (metal oxide semiconductor field effect transistor) within the prognostics and health management of electronics. Experimental results are presented for the identification of the on-resistance as a precursor to failure of devices with die-attach degradation as a failure mechanism. Devices are aged under power cycling in order to trigger die-attach damage. In situ measurements of key electrical and thermal parameters are collected throughout the aging process and further used for analysis and computation of the on-resistance parameter. Experimental results show that the devices experience die-attach damage and that the on-resistance captures the degradation process in such a way that it could be used for the development of prognostics algorithms (data-driven or physics-based).

  19. Lattice design of the integrable optics test accelerator and optical stochastic cooling experiment at Fermilab

    NASA Astrophysics Data System (ADS)

    Kafka, Gene

    The Integrable Optics Test Accelerator (IOTA) storage ring at Fermilab will serve as the backbone for a broad spectrum of Advanced Accelerator R&D (AARD) experiments, and as such, must be designed with significant flexibility in mind, but without compromising cost efficiency. The nonlinear experiments at IOTA will include: achievement of a large nonlinear tune shift/spread without degradation of dynamic aperture; suppression of strong lattice resonances; study of stability of nonlinear systems to perturbations; and studies of different variants of nonlinear magnet design. The ring optics control has challenging requirements that reach or exceed the present state of the art. The development of a complete self-consistent design of the IOTA ring optics, meeting the demands of all planned AARD experiments, is presented. Of particular interest are the precise control for nonlinear integrable optics experiments and the transverse-to-longitudinal coupling and phase stability for the Optical Stochastic Cooling Experiment (OSC). Since the beam time-of-flight must be tightly controlled in the OSC section, studies of second order corrections in this section are presented.

  20. High Frequency, High Gradient Dielectric Wakefield Acceleration Experiments at SLAC and BNL

    SciTech Connect

    Rosenzweig, James; Travish, Gil; Hogan, Mark; Muggli, Patric; /Southern California U.

    2012-07-05

    Given the recent success of >GV/m dielectric wakefield accelerator (DWA) breakdown experiments at SLAC, and follow-on coherent Cerenkov radiation production at the UCLA Neptune, a UCLA-USC-SLAC collaboration is now implementing a new set of experiments that explore various DWA scenarios. These experiments are motivated by the opportunities presented by the approval of FACET facility at SLAC, as well as unique pulse-train wakefield drivers at BNL. The SLAC experiments permit further exploration of the multi-GeV/m envelope in DWAs, and will entail investigations of novel materials (e.g. CVD diamond) and geometries (Bragg cylindrical structures, slab-symmetric DWAs), and have an over-riding goal of demonstrating >GeV acceleration in {approx}33 cm DWA tubes. In the nearer term before FACET's commissioning, we are planning measurements at the BNL ATF, in which we drive {approx}50-200 MV/m fields with single pulses or pulse trains. These experiments are of high relevance to enhancing linear collider DWA designs, as they will demonstrate potential for efficient operation with pulse trains.

  1. Informed Practice: Students' Clinical Experiences in the Undergraduate Phase of an Accelerated Physician Assistant Program.

    PubMed

    Dereczyk, Amy; DeWitt, Rachel

    2016-06-01

    This qualitative study explored the clinical experiences of students in an accelerated physician assistant (PA) program. The participants were either certified nursing assistants (CNAs) or emergency medical technicians-basic (EMTs-B). The study was designed to elicit (1) how the participants perceived their older patients and (2) how the participants' experiences might affect their own future communications, bedside manner, and clinical preparedness as PAs. This study used a focus group to explore students' clinical experiences before the graduate phase of their accelerated PA program. Five female and 2 male PA students (N = 7) participated in the study. All participants were 23 years old and worked as either a CNA or an EMT-B. Results fell into 2 basic themes: informing practice and forming relationships. Regarding the first theme, participants felt that their experience as entry-level health care providers allowed them to improve their communication skills and bedside manner and to provide greater comfort to patients. Regarding the second theme, participants gained appreciation for older people and began to recognize the knowledge deficits and learning needs of their patients. The results suggested that a student's clinical experience as a CNA or an EMT-B before entering a PA program has a positive effect on the student's personal and professional development. The participants acquired greater appreciation and respect for older patients and members of the health care team. PMID:27123599

  2. Lattice design of the integrable optics test accelerator and optical stochastic cooling experiment at Fermilab

    SciTech Connect

    Kafka, Gene

    2015-05-01

    The Integrable Optics Test Accelerator (IOTA) storage ring at Fermilab will serve as the backbone for a broad spectrum of Advanced Accelerator R&D (AARD) experiments, and as such, must be designed with signi cant exibility in mind, but without compromising cost e ciency. The nonlinear experiments at IOTA will include: achievement of a large nonlinear tune shift/spread without degradation of dynamic aperture; suppression of strong lattice resonances; study of stability of nonlinear systems to perturbations; and studies of di erent variants of nonlinear magnet design. The ring optics control has challenging requirements that reach or exceed the present state of the art. The development of a complete self-consistent design of the IOTA ring optics, meeting the demands of all planned AARD experiments, is presented. Of particular interest are the precise control for nonlinear integrable optics experiments and the transverse-to-longitudinal coupling and phase stability for the Optical Stochastic Cooling Experiment (OSC). Since the beam time-of- ight must be tightly controlled in the OSC section, studies of second order corrections in this section are presented.

  3. Resin composite characterizations following a simplified protocol of accelerated aging as a function of the expiration date.

    PubMed

    D'Alpino, Paulo Henrique Perlatti; Vismara, Marcus Vinícius Gonçalves; Mello, Luciano Marcelo de Medeiros; Di Hipólito, Vinicius; González, Alejandra Hortencia Miranda; Graeff, Carlos Frederico de Oliveira

    2014-07-01

    This study evaluated the mechanical, thermal, and morphological characteristics of different classifications of dental composites as a function of the material condition (new, aged and expired). Specimens were obtained according to these factors: Composites: Filtek P60, Filtek Z250, Filtek Z350XT, and Filtek Silorane; and Material conditions: new, aged, and expired. The syringe composites underwent an accelerated aging protocol (Arrhenius model). The flexural strength (FS) and flexural modulus (E) were obtained. The thermogravimetric analysis (TGA) and differential thermal analysis (DTA) were also performed and the glass transition temperature (Tg) and the weight loss calculated. Topographic analysis of the composites was performed under SEM. The material conditions influenced the mechanical properties of the composites. The silorane composite exhibited a characteristic thermal behavior different from that of the methacrylates. In general, the Tg increased after the accelerated aging protocol and decreased for expired ones, compared to the new composites. A significant increase in FS of Filtek Z350XT after aging was accompanied by an increase in the Tg. The filler packings were in accordance with the manufacture׳s information. The topographic aspects of the composites were modified as a function of the material condition. The mechanical properties of the composites following a simplified protocol of accelerated aging varied as a function of the expiration date. The silorane composite presented a characteristic thermal behavior. Although the dental manufacturers may not be able to control variables as storage temperature and transportation conditions, these effects on the composite clinical performance can be minimized if properly considered.

  4. Coffee Silverskin Extract Protects against Accelerated Aging Caused by Oxidative Agents.

    PubMed

    Iriondo-DeHond, Amaia; Martorell, Patricia; Genovés, Salvador; Ramón, Daniel; Stamatakis, Konstantinos; Fresno, Manuel; Molina, Antonio; Del Castillo, Maria Dolores

    2016-01-01

    Nowadays, coffee beans are almost exclusively used for the preparation of the beverage. The sustainability of coffee production can be achieved introducing new applications for the valorization of coffee by-products. Coffee silverskin is the by-product generated during roasting, and because of its powerful antioxidant capacity, coffee silverskin aqueous extract (CSE) may be used for other applications, such as antiaging cosmetics and dermaceutics. This study aims to contribute to the coffee sector's sustainability through the application of CSE to preserve skin health. Preclinical data regarding the antiaging properties of CSE employing human keratinocytes and Caenorhabditis elegans are collected during the present study. Accelerated aging was induced by tert-butyl hydroperoxide (t-BOOH) in HaCaT cells and by ultraviolet radiation C (UVC) in C. elegans. Results suggest that the tested concentrations of coffee extracts were not cytotoxic, and CSE 1 mg/mL gave resistance to skin cells when oxidative damage was induced by t-BOOH. On the other hand, nematodes treated with CSE (1 mg/mL) showed a significant increased longevity compared to those cultured on a standard diet. In conclusion, our results support the antiaging properties of the CSE and its great potential for improving skin health due to its antioxidant character associated with phenols among other bioactive compounds present in the botanical material. PMID:27258247

  5. Degradation mechanism of LiCoO2/mesocarbon microbeads battery based on accelerated aging tests

    NASA Astrophysics Data System (ADS)

    Guan, Ting; Zuo, Pengjian; Sun, Shun; Du, Chunyu; Zhang, Lingling; Cui, Yingzhi; Yang, Lijie; Gao, Yunzhi; Yin, Geping; Wang, Fuping

    2014-12-01

    A series of LiCoO2/mesocarbon microbeads (MCMB) commercial cells cycled at different rates (0.6C, 1.2C, 1.5C, 1.8C, 2.4C and 3.0C) are disassembled and the capacity fade mechanism is proposed by analyzing the structure, morphology and electrochemical performance evolution at the capacity retention of 95%, 90%, 85%, 80%. The capacity deterioration of the commercial cell is mainly caused by the decay of the reversible capacity of LiCoO2 cathode, the irreversible loss of active lithium and the lithium remaining in anode. The proportions of effects by the above three factors are calculated accurately. The consumption of the active lithium leads to a cell imbalance between the anode and the cathode. The electrochemical test results indicate that the capacity fade of the active materials at the low rate is more obvious than that at the high rate. The influence of the active lithium is gradually increscent with the increasing rate. The rate of 1.5C is the optimal value to accelerate the aging of the full cell by comparing the testing results at different capacity retentions in the specific condition of low charge/discharge rate and shallow depth of discharge.

  6. Composites Associated with Pulp-Protection Material: Color-Stability Analysis after Accelerated Artificial Aging

    PubMed Central

    Cruvinel, Diogo Rodrigues; Garcia, Lucas da Fonseca Roberti; Consani, Simonides; de Carvalho Panzeri Pires-de-Souza, Fernanda

    2010-01-01

    Objectives: This study assessed the color stability of two composites associated with two pulp protectors submitted to accelerated artificial aging (AAA). Methods: 60 test specimens were made with 0.5 mm of protection material (calcium hydroxide - CH or glass ionomer cement - GIC) and 2.5 mm of restoration material (Concept or QuixFil) and divided into 3 groups (n=10) according to the type of protection material/composite, and the control group (no protection). After polishing, color readings were obtained with a spectrophotometer (PCB 6807 Byk Gardner) before and after AAA for 384 hours, and L*, a*, and b* coordinates and total color variation (ΔE) were analyzed (2-way ANOVA, Bonferroni, α=05). Results: Composites placed on CH presented lower L* levels than those on GIC, which presented higher L* values than the control group and lower b* values than those of the CH group. The Concept composite presented higher ΔE levels for all groups, differing statistically from QuixFil, except when placed on GIC. Conclusions: It was concluded that the protection material could affect the color stability and AAA is a factor that enhances this effect, depending on the type of composite used. PMID:20046473

  7. Microstructure and mechanical properties of composite resins subjected to accelerated artificial aging.

    PubMed

    dos Reis, Andréa Cândido; de Castro, Denise Tornavoi; Schiavon, Marco Antônio; da Silva, Leandro Jardel; Agnelli, José Augusto Marcondes

    2013-01-01

    The aim of this study was to investigate the influence of accelerated artificial aging (AAA) on the microstructure and mechanical properties of the Filtek Z250, Filtek Supreme, 4 Seasons, Herculite, P60, Tetric Ceram, Charisma and Filtek Z100. composite resins. The composites were characterized by Fourier-transform Infrared spectroscopy (FTIR) and thermal analyses (Differential Scanning Calorimetry - DSC and Thermogravimetry - TG). The microstructure of the materials was examined by scanning electron microscopy. Surface hardness and compressive strength data of the resins were recorded and the mean values were analyzed statistically by ANOVA and Tukey's test (α=0.05). The results showed significant differences among the commercial brands for surface hardness (F=86.74, p<0.0001) and compressive strength (F=40.31, p<0.0001), but AAA did not affect the properties (surface hardness: F=0.39, p=0.53; compressive strength: F=2.82, p=0.09) of any of the composite resins. FTIR, DSC and TG analyses showed that resin polymerization was complete, and there were no differences between the spectra and thermal curve profiles of the materials obtained before and after AAA. TG confirmed the absence of volatile compounds and evidenced good thermal stability up to 200 °C, and similar amounts of residues were found in all resins evaluated before and after AAA. The AAA treatment did not significantly affect resin surface. Therefore, regardless of the resin brand, AAA did not influence the microstructure or the mechanical properties.

  8. Evaluation of stone durability using a combination of ultrasound, mechanical and accelerated aging tests

    NASA Astrophysics Data System (ADS)

    Molina, E.; Cultrone, G.; Sebastián, E.; Alonso, F. J.

    2013-06-01

    The durability of a rock when exposed to decay agents is an important criterion when assessing its quality as a building material. Our study focuses on six varieties of natural stone (two limestones, one dolostone, one travertine and two sandstones) that are widely used in both new and historical buildings. In order to assess their quality, we measured and characterized their dynamic elastic properties using ultrasounds, we measured their compressive strength using the uniaxial compression test and we evaluated their durability by means of accelerated aging tests (freeze-thaw and salt crystallization). In order to get a full picture of the decay suffered by the different stones, we determined the composition and amount of the clay fraction of the six stones. We also observed small fragments subjected to the salt crystallization test under an environmental scanning electron microscope to study any textural change and measured the changes of colour on the surface with a spectrophotometer. Finally, we analysed the pore system of the stones before and after their deterioration using mercury injection porosimetry. We then compared the results for the different stones and found that dolostone obtained the best results, while the two limestones proved to be the least durable and had the lowest compressive strength.

  9. Coffee Silverskin Extract Protects against Accelerated Aging Caused by Oxidative Agents.

    PubMed

    Iriondo-DeHond, Amaia; Martorell, Patricia; Genovés, Salvador; Ramón, Daniel; Stamatakis, Konstantinos; Fresno, Manuel; Molina, Antonio; Del Castillo, Maria Dolores

    2016-01-01

    Nowadays, coffee beans are almost exclusively used for the preparation of the beverage. The sustainability of coffee production can be achieved introducing new applications for the valorization of coffee by-products. Coffee silverskin is the by-product generated during roasting, and because of its powerful antioxidant capacity, coffee silverskin aqueous extract (CSE) may be used for other applications, such as antiaging cosmetics and dermaceutics. This study aims to contribute to the coffee sector's sustainability through the application of CSE to preserve skin health. Preclinical data regarding the antiaging properties of CSE employing human keratinocytes and Caenorhabditis elegans are collected during the present study. Accelerated aging was induced by tert-butyl hydroperoxide (t-BOOH) in HaCaT cells and by ultraviolet radiation C (UVC) in C. elegans. Results suggest that the tested concentrations of coffee extracts were not cytotoxic, and CSE 1 mg/mL gave resistance to skin cells when oxidative damage was induced by t-BOOH. On the other hand, nematodes treated with CSE (1 mg/mL) showed a significant increased longevity compared to those cultured on a standard diet. In conclusion, our results support the antiaging properties of the CSE and its great potential for improving skin health due to its antioxidant character associated with phenols among other bioactive compounds present in the botanical material.

  10. The effects of age and experience on accidents with injuries: should the licensing age be raised?

    PubMed

    Laberge-Nadeau, C; Maag, U; Bourbeau, R

    1992-04-01

    In Canadian Provinces and in several states of the United States the minimal legal age to drive a motor vehicle is 16 years old and in some, it is 15. The excess mortality and morbidity registered by 15 to 24-year-old drivers is well known. Several studies have reported that accident rates decrease with experience, but the effect of the age of new drivers has not been well documented. The objective is to study injury accident rates in terms of the age and experience factors. The data sources are computer files of the Government Insurance Corporation (Société de l'assurance automobile du Québec), which covers all Quebec drivers. For each driver, the file contains birth date, sex, year and month of first license, involvement in accidents, and other parameters. The yearly rates (1970-1984) of new permits per age last birthday and sex show an increase over time, particularly for 16-year-old men. For the period 1979-1984, injury accident involvement rates were computed for all Quebec drivers by age, sex, and driving experience. An experienced driver has been defined as a person who has been licensed for at least one year. The results show, for experienced as well as inexperienced young men (16-18), a high injury accident rate that decreases with age. For women, the rates are much lower and decrease more gradually than for men. This study does not take into account the kilometers driven. Since young drivers (16-18) have the highest accident rates, the question of regulating access to first licensing for such drivers must be examined as a possible strategy for injury prevention. PMID:1558618

  11. STS-40 orbital acceleration research experiment flight results during a typical sleep period

    NASA Technical Reports Server (NTRS)

    Blanchard, R. C.; Nicholson, J. Y.; Ritter, J. R.

    1992-01-01

    The Orbital Acceleration Research Experiment (OARE), an electrostatic accelerometer package with complete on-orbit calibration capabilities, was flown for the first time aboard the Space Shuttle on STS-40. This is also the first time an accelerometer package with nano-g sensitivity and a calibration facility has flown aboard the Space Shuttle. The instrument is designed to measure and record the Space Shuttle aerodynamic acceleration environment from the free molecule flow regime through the rarified flow transition into the hypersonic continuum regime. Because of its sensitivity, the OARE instrument defects aerodynamic behavior of the Space Shuttle while in low-earth orbit. A 2-hour orbital time period on day seven of the mission, when the crew was asleep and other spacecraft activities were at a minimum, was examined. During the flight, a 'trimmed-mean' filter was used to produce high quality, low frequency data which was successfully stored aboard the Space Shuttle in the OARE data storage system. Initial review of the data indicated that, although the expected precision was achieved, some equipment problems occurred resulting in uncertain accuracy. An acceleration model which includes aerodynamic, gravity-gradient, and rotational effects was constructed and compared with flight data. Examination of the model with the flight data shows the instrument to be sensitive to all major expected low frequency acceleration phenomena; however, some erratic instrument bias behavior persists in two axes. In these axes, the OARE data can be made to match a comprehensive atmospheric-aerodynamic model by making bias adjustments and slight linear corrections for drift. The other axis does not exhibit these difficulties and gives good agreement with the acceleration model.

  12. Beam dynamics studies for the relativistic klystron two-beam accelerator experiment

    NASA Astrophysics Data System (ADS)

    Lidia, Steven M.

    2001-04-01

    Two-beam accelerators (TBAs) have been proposed as efficient power sources for next generation high-energy linear colliders. Studies have demonstrated the possibility of building TBAs from X-band \\(~8-12 GHz\\) through Ka-band \\(~30-35 GHz\\) frequency regions. The relativistic klystron two-beam accelerator project, whose aim is to study TBAs based upon extended relativistic klystrons, is described, and a new simulation code is used to design the latter portions of the experiment. Detailed, self-consistent calculations of the beam dynamics and of the rf cavity output are presented and discussed together with a beam line design that will generate nearly 1.2 GW of power from 40 rf cavities over a 10 m distance. The simulations show that beam current losses are acceptable and that longitudinal and transverse focusing techniques are sufficiently capable of maintaining a high degree of beam quality along the entire beam line.

  13. Beryllium liner implosion experiments on the Z accelerator in preparation for magnetized liner inertial fusion

    SciTech Connect

    McBride, R. D.; Martin, M. R.; Lemke, R. W.; Jennings, C. A.; Rovang, D. C.; Sinars, D. B.; Cuneo, M. E.; Herrmann, M. C.; Slutz, S. A.; Nakhleh, C. W.; Davis, J.-P.; Flicker, D. G.; Rogers, T. J.; Robertson, G. K.; Kamm, R. J.; Smith, I. C.; Savage, M.; Stygar, W. A.; Rochau, G. A.; Jones, M.; and others

    2013-05-15

    Multiple experimental campaigns have been executed to study the implosions of initially solid beryllium (Be) liners (tubes) on the Z pulsed-power accelerator. The implosions were driven by current pulses that rose from 0 to 20 MA in either 100 or 200 ns (200 ns for pulse shaping experiments). These studies were conducted in support of the recently proposed Magnetized Liner Inertial Fusion concept [Slutz et al., Phys. Plasmas 17, 056303 (2010)], as well as for exploring novel equation-of-state measurement techniques. The experiments used thick-walled liners that had an aspect ratio (initial outer radius divided by initial wall thickness) of either 3.2, 4, or 6. From these studies, we present three new primary results. First, we present radiographic images of imploding Be liners, where each liner contained a thin aluminum sleeve for enhancing the contrast and visibility of the liner's inner surface in the images. These images allow us to assess the stability of the liner's inner surface more accurately and more directly than was previously possible. Second, we present radiographic images taken early in the implosion (prior to any motion of the liner's inner surface) of a shockwave propagating radially inward through the liner wall. Radial mass density profiles from these shock compression experiments are contrasted with profiles from experiments where the Z accelerator's pulse shaping capabilities were used to achieve shockless (“quasi-isentropic”) liner compression. Third, we present “micro-B-dot ” measurements of azimuthal magnetic field penetration into the initially vacuum-filled interior of a shocked liner. Our measurements and simulations reveal that the penetration commences shortly after the shockwave breaks out from the liner's inner surface. The field then accelerates this low-density “precursor” plasma to the axis of symmetry.

  14. Age-dependent changes in lipid peroxide levels in peripheral organs, but not in brain, in senescence-accelerated mice.

    PubMed

    Matsugo, S; Kitagawa, T; Minami, S; Esashi, Y; Oomura, Y; Tokumaru, S; Kojo, S; Matsushima, K; Sasaki, K

    2000-01-01

    The tissue concentration of lipid peroxides was determined in the brain, heart, liver, lung and kidney of accelerated senescence-prone (SAMP-8) and -resistant (SAMR-1) mice at 3, 6 and 9 months of age by a method involving chemical derivatization and high performance liquid chromatography. The level of lipid peroxides in the brain did not show an age-dependent change, but at each age the brain level of lipid peroxides was significantly higher in SAMP-8 than in SAMR-1. In contrast, the lipid peroxide levels in the peripheral organs showed increases with aging in both strains, and they were significantly higher in SAMP-8 than in SAMR-1 at both 3 and 6 months of age (except at 3 months of age in the kidney). These results suggest that increased oxidative stress in the brain and peripheral organs is a cause of the senescence-related degeneration and impairments seen in SAMP-8. PMID:10643812

  15. Endocrine and fluid metabolism in males and females of different ages after bedrest, acceleration and lower body negative pressure

    NASA Technical Reports Server (NTRS)

    Leach, C. S.; Vernikos-Danellis, J.; Krauhs, J. M.; Sandler, H.

    1985-01-01

    Space shuttle flight simulations were conducted to determine the effects of weightlessness, lower body negative pressure (LBNP), and acceleration of fluid and electrolyte excretion and the hormones that control it. Measurements were made on male and female subjects of different ages before and after bedrest. After admission to a controlled environment, groups of 6 to 14 subjects in the age ranges 25 to 35, 35 to 45, 45 to 55 to 65 years were exposed to +3 G sub z for 15 minutes (G1) and to LBNP (LBNP1) on different days. On 3 days during this prebedrest period, no tests were conducted. Six days of bedrest followed, and the G sub z (G2) and LBNP (LBNP2) tests were run again. Hormones, electrolytes, and other parameters were measured in 24-hour urine pools throughout the experiment. During bedrest, cortisol and aldosterone excretion increased. Urine volume decreased, and specific gravity and osmolality increased. Urinary electrolytes were statistically unchanged from levels during the non-stress control period. During G2, cortisol increased significantly over its control and bedrest levels. Urine volume, sodium, and chloride were significantly lower; specific gravity and osmolality were higher during the control period or bedrest. The retention of fluids and electrolytes after +G sub z may at least partially explain decreased urine volume and increased osmolality observed during bedrest in this study. There were some who indicated that space flight would not affect the fluid and electrolyte metabolism of females or older males any more severely than it has affected that of male astronauts.

  16. Electromagnetic Safety of Spacecraft During Active Experiments with the Use of Plasma Accelerators and Ion Injectors

    NASA Astrophysics Data System (ADS)

    Plokhikh, Andrey; Popov, Garri; Shishkin, Gennady; Antropov, Nikolay; Vazhenin, Nikolay; Soganova, Galina

    Works under the development and application of stationary and pulsed plasma accelerators of charged particles conducted at the Moscow Aviation Institute and Research Institute of Applied Mechanics and Electrodynamics during over 40 years, active experiments on board meteorological rockets, artificial Earth satellites and "Mir" orbital station including [1], allowed to obtain data on the influence of pulsed and continuous plasma injection with the given parameters on the drop of energetic particles out of the radiation belts, efficiency of artificial excitation and propagation of electromagnetic waves in ELF and VLF ranges, and evolution of artificial plasma formations in different regions of ionosphere. Variation of the near-spacecraft electromagnetic environment related to the operation of plasma injectors was registered during active experiments along with the global electrodynamic processes. The measured electromagnetic fields are of rather high intensity and occupy frequency spectrum from some Hz to tens of GHz that may be of definite danger for the operation of spacecraft and its onboard systems. Analysis for the known test data is presented in the paper and methods are discussed for the diagnostics and modeling under laboratory conditions of radiative processes proceeding at the operation of plasma accelerators and ion injectors used while making active space experiments. Great attention is paid to the methodological and metrological bases for making radio measurements in vacuum chambers, design concept and hardware configuration of ground special-purpose instrumentation scientific complexes [2]. Basic requirements are formulated for the measurements and analysis of electromagnetic fields originating during the operation of plasma accelerators, including the radiative induced and conductive components inside the spacecraft, as well as the wave emission and excitation outside the spacecraft, in the ionosphere including. Measurement results for the intrinsic

  17. Exposure to omega-3 fatty acids at early age accelerate bone growth and improve bone quality.

    PubMed

    Koren, Netta; Simsa-Maziel, Stav; Shahar, Ron; Schwartz, Betty; Monsonego-Ornan, Efrat

    2014-06-01

    Omega-3 fatty acids (FAs) are essential nutritional components that must be obtained from foods. Increasing evidence validate that omega-3 FAs are beneficial for bone health, and several mechanisms have been suggested to mediate their effects on bone, including alterations in calcium absorption and urinary calcium loss, prostaglandin synthesis, lipid oxidation, osteoblast formation and inhibition of osteoclastogenesis. However, to date, there is scant information regarding the effect of omega-3 FAs on the developing skeleton during the rapid growth phase. In this study we aim to evaluate the effect of exposure to high levels of omega-3 FAs on bone development and quality during prenatal and early postnatal period. For this purpose, we used the fat-1 transgenic mice that have the ability to convert omega-6 to omega-3 fatty acids and the ATDC5 chondrogenic cell line as models. We show that exposure to high concentrations of omega-3 FAs at a young age accelerates bone growth through alterations of the growth plate, associated with increased chondrocyte proliferation and differentiation. We further propose that those effects are mediated by the receptors G-protein coupled receptor 120 (GPR120) and hepatic nuclear factor 4α, which are expressed by chondrocytes in culture. Additionally, using a combined study on the structural and mechanical bone parameters, we show that high omega-3 levels contribute to superior trabecular and cortical structure, as well as to stiffer bones and improved bone quality. Most interestingly, the fat-1 model allowed us to demonstrate the role of maternal high omega-3 concentration on bone growth during the gestation and postnatal period.

  18. Hypothalamic leptin gene therapy reduces body weight without accelerating age-related bone loss.

    PubMed

    Turner, Russell T; Dube, Michael; Branscum, Adam J; Wong, Carmen P; Olson, Dawn A; Zhong, Xiaoying; Kweh, Mercedes F; Larkin, Iske V; Wronski, Thomas J; Rosen, Clifford J; Kalra, Satya P; Iwaniec, Urszula T

    2015-12-01

    Excessive weight gain in adults is associated with a variety of negative health outcomes. Unfortunately, dieting, exercise, and pharmacological interventions have had limited long-term success in weight control and can result in detrimental side effects, including accelerating age-related cancellous bone loss. We investigated the efficacy of using hypothalamic leptin gene therapy as an alternative method for reducing weight in skeletally-mature (9 months old) female rats and determined the impact of leptin-induced weight loss on bone mass, density, and microarchitecture, and serum biomarkers of bone turnover (CTx and osteocalcin). Rats were implanted with cannulae in the 3rd ventricle of the hypothalamus and injected with either recombinant adeno-associated virus encoding the gene for rat leptin (rAAV-Leptin, n=7) or a control vector encoding green fluorescent protein (rAAV-GFP, n=10) and sacrificed 18 weeks later. A baseline control group (n=7) was sacrificed at vector administration. rAAV-Leptin-treated rats lost weight (-4±2%) while rAAV-GFP-treated rats gained weight (14±2%) during the study. At study termination, rAAV-Leptin-treated rats weighed 17% less than rAAV-GFP-treated rats and had lower abdominal white adipose tissue weight (-80%), serum leptin (-77%), and serum IGF1 (-34%). Cancellous bone volume fraction in distal femur metaphysis and epiphysis, and in lumbar vertebra tended to be lower (P<0.1) in rAAV-GFP-treated rats (13.5 months old) compared to baseline control rats (9 months old). Significant differences in cancellous bone or biomarkers of bone turnover were not detected between rAAV-Leptin and rAAV-GFP rats. In summary, rAAV-Leptin-treated rats maintained a lower body weight compared to baseline and rAAV-GFP-treated rats with minimal effects on bone mass, density, microarchitecture, or biochemical markers of bone turnover.

  19. Rapid evaluation of the durability of cortical neural implants using accelerated aging with reactive oxygen species

    NASA Astrophysics Data System (ADS)

    Takmakov, Pavel; Ruda, Kiersten; Phillips, K. Scott; Isayeva, Irada S.; Krauthamer, Victor; Welle, Cristin G.

    2015-04-01

    Objective. A challenge for implementing high bandwidth cortical brain-machine interface devices in patients is the limited functional lifespan of implanted recording electrodes. Development of implant technology currently requires extensive non-clinical testing to demonstrate device performance. However, testing the durability of the implants in vivo is time-consuming and expensive. Validated in vitro methodologies may reduce the need for extensive testing in animal models. Approach. Here we describe an in vitro platform for rapid evaluation of implant stability. We designed a reactive accelerated aging (RAA) protocol that employs elevated temperature and reactive oxygen species (ROS) to create a harsh aging environment. Commercially available microelectrode arrays (MEAs) were placed in a solution of hydrogen peroxide at 87 °C for a period of 7 days. We monitored changes to the implants with scanning electron microscopy and broad spectrum electrochemical impedance spectroscopy (1 Hz-1 MHz) and correlated the physical changes with impedance data to identify markers associated with implant failure. Main results. RAA produced a diverse range of effects on the structural integrity and electrochemical properties of electrodes. Temperature and ROS appeared to have different effects on structural elements, with increased temperature causing insulation loss from the electrode microwires, and ROS concentration correlating with tungsten metal dissolution. All array types experienced impedance declines, consistent with published literature showing chronic (>30 days) declines in array impedance in vivo. Impedance change was greatest at frequencies <10 Hz, and smallest at frequencies 1 kHz and above. Though electrode performance is traditionally characterized by impedance at 1 kHz, our results indicate that an impedance change at 1 kHz is not a reliable predictive marker of implant degradation or failure. Significance. ROS, which are known to be present in vivo, can create

  20. Poor maternal nutrition and accelerated postnatal growth induces an accelerated aging phenotype and oxidative stress in skeletal muscle of male rats

    PubMed Central

    Fernandez-Twinn, Denise S.; Chen, Jian Hua; Hargreaves, Iain P.; Neergheen, Viruna; Aiken, Catherine E.; Ozanne, Susan E.

    2016-01-01

    ABSTRACT ‘Developmental programming’, which occurs as a consequence of suboptimal in utero and early environments, can be associated with metabolic dysfunction in later life, including an increased incidence of cardiovascular disease and type 2 diabetes, and predisposition of older men to sarcopenia. However, the molecular mechanisms underpinning these associations are poorly understood. Many conditions associated with developmental programming are also known to be associated with the aging process. We therefore utilized our well-established rat model of low birth weight and accelerated postnatal catch-up growth (termed ‘recuperated’) in this study to establish the effects of suboptimal maternal nutrition on age-associated factors in skeletal muscle. We demonstrated accelerated telomere shortening (a robust marker of cellular aging) as evidenced by a reduced frequency of long telomeres (48.5-8.6 kb) and an increased frequency of short telomeres (4.2-1.3 kb) in vastus lateralis muscle from aged recuperated offspring compared to controls. This was associated with increased protein expression of the DNA-damage-repair marker 8-oxoguanine-glycosylase (OGG1) in recuperated offspring. Recuperated animals also demonstrated an oxidative stress phenotype, with decreased citrate synthase activity, increased electron-transport-complex activities of complex I, complex II-III and complex IV (all markers of functional mitochondria), and increased xanthine oxidase (XO), p67phox and nuclear-factor kappa-light-chain-enhancer of activated B-cells (NF-κB). Recuperated offspring also demonstrated increased antioxidant defense capacity, with increased protein expression of manganese superoxide dismutase (MnSOD), copper-zinc superoxide dismutase (CuZnSOD), catalase and heme oxygenase-1 (HO1), all of which are known targets of NF-κB and can be upregulated as a consequence of oxidative stress. Recuperated offspring also had a pro-inflammatory phenotype, as evidenced by

  1. Transport calculations and accelerator experiments needed for radiation risk assessment in space.

    PubMed

    Sihver, Lembit

    2008-01-01

    The major uncertainties on space radiation risk estimates in humans are associated to the poor knowledge of the biological effects of low and high LET radiation, with a smaller contribution coming from the characterization of space radiation field and its primary interactions with the shielding and the human body. However, to decrease the uncertainties on the biological effects and increase the accuracy of the risk coefficients for charged particles radiation, the initial charged-particle spectra from the Galactic Cosmic Rays (GCRs) and the Solar Particle Events (SPEs), and the radiation transport through the shielding material of the space vehicle and the human body, must be better estimated Since it is practically impossible to measure all primary and secondary particles from all possible position-projectile-target-energy combinations needed for a correct risk assessment in space, accurate particle and heavy ion transport codes must be used. These codes are also needed when estimating the risk for radiation induced failures in advanced microelectronics, such as single-event effects, etc., and the efficiency of different shielding materials. It is therefore important that the models and transport codes will be carefully benchmarked and validated to make sure they fulfill preset accuracy criteria, e.g. to be able to predict particle fluence, dose and energy distributions within a certain accuracy. When validating the accuracy of the transport codes, both space and ground based accelerator experiments are needed The efficiency of passive shielding and protection of electronic devices should also be tested in accelerator experiments and compared to simulations using different transport codes. In this paper different multipurpose particle and heavy ion transport codes will be presented, different concepts of shielding and protection discussed, as well as future accelerator experiments needed for testing and validating codes and shielding materials. PMID:19205295

  2. The AEgIS experiment at CERN for the measurement of antihydrogen gravity acceleration

    NASA Astrophysics Data System (ADS)

    Scampoli, Paola; Storey, James

    2014-05-01

    The Antihydrogen Experiment: Gravity, Interferometry, Spectroscopy (AEgIS) experiment is conducted by an international collaboration based at CERN whose aim is to perform the first direct measurement of the gravitational acceleration of antihydrogen in the local field of the Earth, with Δg/g = 1% precision as a first achievement. The idea is to produce cold (100 mK) antihydrogen (\\bar H) through a pulsed charge exchange reaction by overlapping clouds of antiprotons, from the Antiproton Decelerator (AD) and positronium atoms inside a Penning trap. The antihydrogen has to be produced in an excited Rydberg state to be subsequently accelerated to form a beam. The deflection of the antihydrogen beam can then be measured by using a moiré deflectometer coupled to a position sensitive detector to register the impact point of the anti-atoms through the vertex reconstruction of their annihilation products. After being approved in late 2008, AEgIS started taking data in a commissioning phase in 2012. This paper presents an outline of the experiment with a brief overview of its physics motivation and of the state-of-the-art of the g measurement on antimatter. Particular attention is given to the current status of the emulsion-based position detector needed to measure the \\bar H sag in AEgIS.

  3. Falling antimatter: An experiment to measure the gravitational acceleration of the antiproton

    SciTech Connect

    Dyer, P.; Camp, J.; Holzscheiter, M.H.; Graessle, S.

    1988-01-01

    According to some theories of gravity, antimatter will fall faster than matter in the earth's gravitational field. An experiment to measure the gravitational force on the antiproton is under construction. Antiprotons of a few MeV from the LEAR facility of CERN will be slowed down and caught in a large Penning electromagnetic trap. They will then be cooled and transferred to Penning cooling and launching traps. The gravitational acceleration will be measured by the time-of-flight in a drift tube shielding stray electronic fields, and will be compared with that measured for H/sup /minus// ions. Progress on a number of fronts is described. 9 refs., 2 figs.

  4. Development of electron beam accelerator for SEPAC experiment on Spacelab One

    NASA Astrophysics Data System (ADS)

    Kawashima, N.; Kudo, I.; Goma, K.

    Design and performance features of the electron beam accelerator (EBA) to be used on the SEPAC experiment on the Spacelab One Shuttle mission are described. The EBA comprises an electron gun, power supply, and a high voltage converter (HVC). Numerical models were developed for the functional performances of the 20 mm diam beam intensity and the focusing and deflection coils. Functional features of the anode, heater, focusing and deflection and auxiliary power supply systems, and the HVC, controller, and redundancy features are provided. A mission simulation, verified that all mission objectives could be met with the device, including avoidance of electromagnetic interference with other Shuttle activities and equipment.

  5. Vibration isolation technology: Sensitivity of selected classes of space experiments to residual accelerations

    NASA Technical Reports Server (NTRS)

    Alexander, J. Iwan D.; Zhang, Y. Q.; Adebiyi, Adebimpe

    1989-01-01

    Progress performed on each task is described. Order of magnitude analyses related to liquid zone sensitivity and thermo-capillary flow sensitivity are covered. Progress with numerical models of the sensitivity of isothermal liquid zones is described. Progress towards a numerical model of coupled buoyancy-driven and thermo-capillary convection experiments is also described. Interaction with NASA personnel is covered. Results to date are summarized and they are discussed in terms of the predicted space station acceleration environment. Work planned for the second year is also discussed.

  6. Investigation of neutrino oscillations in the T2k long-baseline accelerator experiment

    SciTech Connect

    Izmaylov, A. O. Yershov, N. V.; Kudenko, Yu. G.; Matveev, V. A.; Mineev, O. V.; Musienko, Yu. V.; Khabibulliun, M. M.; Khotjantsev, A. N.; Shaykhiev, A. T.

    2012-02-15

    High-sensitivity searches for transitions of muon neutrinos to electron neutrinos are the main task of the T2K (Tokai-to-Kamioka) second-generation long-baseline accelerator neutrino experiment. The present article is devoted to describing basic principles of T2K, surveying experimental apparatuses that it includes, and considering in detail the muon-range detector (SMRD) designed and manufactured by a group of physicists from the Institute of Nuclear Research (Russian Academy of Sciences, Moscow). The results of the first measurements with a neutrino beam are presented, and plans for the near future are discussed.

  7. Evidence for muon neutrino oscillation in an accelerator-based experiment.

    PubMed

    Aliu, E; Andringa, S; Aoki, S; Argyriades, J; Asakura, K; Ashie, R; Berns, H; Bhang, H; Blondel, A; Borghi, S; Bouchez, J; Burguet-Castell, J; Casper, D; Cavata, C; Cervera, A; Cho, K O; Choi, J H; Dore, U; Espinal, X; Fechner, M; Fernandez, E; Fukuda, Y; Gomez-Cadenas, J; Gran, R; Hara, T; Hasegawa, M; Hasegawa, T; Hayashi, K; Hayato, Y; Helmer, R L; Hill, J; Hiraide, K; Hosaka, J; Ichikawa, A K; Iinuma, M; Ikeda, A; Inagaki, T; Ishida, T; Ishihara, K; Ishii, T; Ishitsuka, M; Itow, Y; Iwashita, T; Jang, H I; Jeon, E J; Jeong, I S; Joo, K; Jover, G; Jung, C K; Kajita, T; Kameda, J; Kaneyuki, K; Kato, I; Kearns, E; Kerr, D; Kim, C O; Khabibullin, M; Khotjantsev, A; Kielczewska, D; Kim, J Y; Kim, S; Kitching, P; Kobayashi, K; Kobayashi, T; Konaka, A; Koshio, Y; Kropp, W; Kubota, J; Kudenko, Yu; Kuno, Y; Kutter, T; Learned, J; Likhoded, S; Lim, I T; Loverre, P F; Ludovici, L; Maesaka, H; Mallet, J; Mariani, C; Maruyama, T; Matsuno, S; Matveev, V; Mauger, C; McConnel, K; McGrew, C; Mikheyev, S; Minamino, A; Mine, S; Mineev, O; Mitsuda, C; Miura, M; Moriguchi, Y; Morita, T; Moriyama, S; Nakadaira, T; Nakahata, M; Nakamura, K; Nakano, I; Nakaya, T; Nakayama, S; Namba, T; Nambu, R; Nawang, S; Nishikawa, K; Nitta, K; Nova, F; Novella, P; Obayashi, Y; Okada, A; Okumura, K; Oser, S M; Oyama, Y; Pac, M Y; Pierre, F; Rodriguez, A; Saji, C; Sakuda, M; Sanchez, F; Sarrat, A; Sasaki, T; Scholberg, K; Schroeter, R; Sekiguchi, M; Sharkey, E; Shiozawa, M; Shiraishi, K; Sitjes, G; Smy, M; Sobel, H; Stone, J; Sulak, L; Suzuki, A; Suzuki, Y; Takahashi, T; Takenaga, Y; Takeuchi, Y; Taki, K; Takubo, Y; Tamura, N; Tanaka, M; Terri, R; T'Jampens, S; Tornero-Lopez, A; Totsuka, Y; Ueda, S; Vagins, M; Walter, C W; Wang, W; Wilkes, R J; Yamada, S; Yamamoto, S; Yanagisawa, C; Yershov, N; Yokoyama, H; Yokoyama, M; Yoo, J; Yoshida, M; Zalipska, J

    2005-03-01

    We present results for nu(mu) oscillation in the KEK to Kamioka (K2K) long-baseline neutrino oscillation experiment. K2K uses an accelerator-produced nu(mu) beam with a mean energy of 1.3 GeV directed at the Super-Kamiokande detector. We observed the energy-dependent disappearance of nu(mu), which we presume have oscillated to nu(tau). The probability that we would observe these results if there is no neutrino oscillation is 0.0050% (4.0 sigma).

  8. The UCLA/SLAC Ultra-High Gradient Cerenkov Wakefield Accelerator Experiment

    SciTech Connect

    Thompson, M.C.; Badakov, H.; Rosenzweig, J.B.; Travish, G.; Hogan, M.; Ischebec, R.; Siemann, R.; Walz, D.; Scott, A.; Yoder, R.; /Manhattan Coll., Riverdale

    2006-01-25

    An experiment is planned to study the performance of dielectric Cerenkov wakefield accelerating structures at extremely high gradients in the GV/m range. This new UCLA/SLAC/USC collaboration will take advantage of the unique SLAC FFTB electron beam and its demonstrated ultra-short pulse lengths and high currents (e.g., {delta}{sub z} = 20 {micro}m at Q = 3 nC). The electron beam will be focused down and sent through varying lengths of fused silica capillary tubing with two different sizes: ID = 200 {micro}m/OD = 325 {micro}m and ID = 100 {micro}m/OD = 325 {micro}m. The pulse length of the electron beam will be varied in order to alter the accelerating gradient and probe the breakdown threshold of the dielectric structures. In addition to breakdown studies, we plan to collect and measure coherent Cerenkov radiation emitted from the capillary tube to gain information about the strength of the accelerating fields.

  9. Experimental induction of type 2 diabetes in aging-accelerated mice triggered Alzheimer-like pathology and memory deficits.

    PubMed

    Mehla, Jogender; Chauhan, Balwantsinh C; Chauhan, Neelima B

    2014-01-01

    Alzheimer's disease (AD) is an age-dependent neurodegenerative disease constituting ~95% of late-onset non-familial/sporadic AD, and only ~5% accounting for early-onset familial AD. Availability of a pertinent model representing sporadic AD is essential for testing candidate therapies. Emerging evidence indicates a causal link between diabetes and AD. People with diabetes are >1.5-fold more likely to develop AD. Senescence-accelerated mouse model (SAMP8) of accelerated aging displays many features occurring early in AD. Given the role played by diabetes in the pre-disposition of AD, and the utility of SAMP8 non-transgenic mouse model of accelerated aging, we examined if high fat diet-induced experimental type 2 diabetes in SAMP8 mice will trigger pathological aging of the brain. Results showed that compared to non-diabetic SAMP8 mice, diabetic SAMP8 mice exhibited increased cerebral amyloid-β, dysregulated tau-phosphorylating glycogen synthase kinase 3β, reduced synaptophysin immunoreactivity, and displayed memory deficits, indicating Alzheimer-like changes. High fat diet-induced type 2 diabetic SAMP8 mice may represent the metabolic model of AD.

  10. Experimental Induction of Type 2 Diabetes in Aging-Accelerated Mice Triggered Alzheimer-Like Pathology and Memory Deficits

    PubMed Central

    Mehla, Jogender; Chauhan, Balwantsinh C.; Chauhan, Neelima B.

    2014-01-01

    Alzheimer’s disease (AD) is an age-dependent neurodegenerative disease constituting ~95% of late-onset non-familial/sporadic AD, and only ~5% accounting for early-onset familial AD. Availability of a pertinent model representing sporadic AD is essential for testing candidate therapies. Emerging evidence indicates a causal link between diabetes and AD. People with diabetes are >1.5-fold more likely to develop AD. Senescence-accelerated mouse model (SAMP8) of accelerated aging displays many features occurring early in AD. Given the role played by diabetes in the pre-disposition of AD, and the utility of SAMP8 non-transgenic mouse model of accelerated aging, we examined if high fat diet-induced experimental type 2 diabetes in SAMP8 mice will trigger pathological aging of the brain. Results showed that compared to non-diabetic SAMP8 mice, diabetic SAMP8 mice exhibited increased cerebral amyloid-β, dysregulated tau-phosphorylating glycogen synthase kinase 3β, reduced synaptophysin immunoreactivity, and displayed memory deficits, indicating Alzheimer-like changes. High fat diet-induced type 2 diabetic SAMP8 mice may represent the metabolic model of AD. PMID:24121970

  11. Experimental characterization of a coaxial plasma accelerator for a colliding plasma experiment

    SciTech Connect

    Wiechula, J.; Hock, C.; Iberler, M.; Manegold, T.; Schönlein, A.; Jacoby, J.

    2015-04-15

    We report experimental results of a single coaxial plasma accelerator in preparation for a colliding plasma experiment. The utilized device consisted of a coaxial pair of electrodes, accelerating the plasma due to J×B forces. A pulse forming network, composed of three capacitors connected in parallel, with a total capacitance of 27 μF was set up. A thyratron allowed to switch the maximum applied voltage of 9 kV. Under these conditions, the pulsed currents reached peak values of about 103 kA. The measurements were performed in a small vacuum chamber with a neutral-gas prefill at gas pressures between 10 Pa and 14 000 Pa. A gas mixture of ArH{sub 2} with 2.8% H{sub 2} served as the discharge medium. H{sub 2} was chosen in order to observe the broadening of the H{sub β} emission line and thus estimate the electron density. The electron density for a single plasma accelerator reached peak values on the order of 10{sup 16} cm{sup −3}. Electrical parameters, inter alia inductance and resistance, were determined for the LCR circuit during the plasma acceleration as well as in a short circuit case. Depending on the applied voltage, the inductance and resistance reached values ranging from 194 nH to 216 nH and 13 mΩ to 23 mΩ, respectively. Furthermore, the plasma velocity was measured using a fast CCD camera. Plasma velocities of 2 km/s up to 17 km/s were observed, the magnitude being highly correlated with gas pressure and applied voltage.

  12. Experimental characterization of a coaxial plasma accelerator for a colliding plasma experiment

    NASA Astrophysics Data System (ADS)

    Wiechula, J.; Hock, C.; Iberler, M.; Manegold, T.; Schönlein, A.; Jacoby, J.

    2015-04-01

    We report experimental results of a single coaxial plasma accelerator in preparation for a colliding plasma experiment. The utilized device consisted of a coaxial pair of electrodes, accelerating the plasma due to J ×B forces. A pulse forming network, composed of three capacitors connected in parallel, with a total capacitance of 27 μF was set up. A thyratron allowed to switch the maximum applied voltage of 9 kV. Under these conditions, the pulsed currents reached peak values of about 103 kA. The measurements were performed in a small vacuum chamber with a neutral-gas prefill at gas pressures between 10 Pa and 14 000 Pa. A gas mixture of ArH2 with 2.8% H2 served as the discharge medium. H2 was chosen in order to observe the broadening of the Hβ emission line and thus estimate the electron density. The electron density for a single plasma accelerator reached peak values on the order of 1016 cm-3 . Electrical parameters, inter alia inductance and resistance, were determined for the LCR circuit during the plasma acceleration as well as in a short circuit case. Depending on the applied voltage, the inductance and resistance reached values ranging from 194 nH to 216 nH and 13 mΩ to 23 mΩ, respectively. Furthermore, the plasma velocity was measured using a fast CCD camera. Plasma velocities of 2 km/s up to 17 km/s were observed, the magnitude being highly correlated with gas pressure and applied voltage.

  13. Aging reduces experience-induced sensorimotor plasticity. A magnetoencephalographic study.

    PubMed

    Mary, Alison; Bourguignon, Mathieu; Wens, Vincent; Op de Beeck, Marc; Leproult, Rachel; De Tiège, Xavier; Peigneux, Philippe

    2015-01-01

    Modulation of the mu-alpha and mu-beta spontaneous rhythms reflects plastic neural changes within the primary sensorimotor cortex (SM1). Using magnetoencephalography (MEG), we investigated how aging modifies experience-induced plasticity after learning a motor sequence, looking at post- vs. pre-learning changes in the modulation of mu rhythms during the execution of simple hand movements. Fifteen young (18-30 years) and fourteen older (65-75 years) right-handed healthy participants performed auditory-cued key presses using all four left fingers simultaneously (Simple Movement task - SMT) during two separate sessions. Following both SMT sessions, they repeatedly practiced a 5-elements sequential finger-tapping task (FTT). Mu power calculated during SMT was averaged across 18 gradiometers covering the right sensorimotor region and compared before vs. after sequence learning in the alpha (9/10/11Hz) and the beta (18/20/22Hz) bands separately. Source power maps in the mu-alpha and mu-beta bands were localized using Dynamic Statistical Parametric Mapping (dSPM). The FTT sequence was performed faster at retest than at the end of the learning session, indicating an offline boost in performance. Analyses conducted on SMT sessions revealed enhanced rebound after learning in the right SM1, 3000-3500ms after the initiation of movement, in young as compared to older participants. Source reconstruction indicated that mu-beta is located in the precentral gyrus (motor processes) and mu-alpha is located in the postcentral gyrus (somatosensory processes) in both groups. The enhanced post-movement rebound in young subjects potentially reflects post-training plastic changes in SM1. Age-related decreases in post-training modulatory effects suggest reduced experience-dependent plasticity in the aging brain.

  14. High rates of carbon storage in old deciduous forests: Emerging mechanisms from the Forest Accelerated Succession ExperimenT (FASET)

    NASA Astrophysics Data System (ADS)

    Gough, C. M.; Nave, L. E.; Hardiman, B. S.; Bohrer, G.; Halperin, A.; Maurer, K.; Le Moine, J.; Nadelhoffer, K.; Vogel, C. S.; Curtis, P.; University Of Michigan Biological Station Forest Ecosystem Study (Umbs-Fest) Team

    2010-12-01

    Deciduous forests of the eastern US are broadly approaching an ecological threshold in which early successional dominant trees are senescing and giving way to later successional species, with unknown consequences for regional carbon (C) cycling. Though recent research demonstrates that forests may accumulate C for centuries, the mechanisms behind sustained rates of C storage in old, particularly deciduous, forests have not been identified. In a regionally representative forest at the University of Michigan Biological Station, we are combining observational and experimental C cycling studies to forecast how forest C storage responds to climate variation, disturbance, and succession. The Forest Accelerated Succession ExperimenT (FASET), in which >6,700 aspen and birch trees (~35 % LAI) were stem girdled within a 39 ha area, is testing the hypothesis that forest production will increase rather than decline with age, due to increases in nitrogen (N) availability, N allocation to the canopy, and the concurrent development of a more biologically and structurally complex canopy. Results thus far support our hypothesis that aging forests in the region may sustain high rates of C storage through shifts in N cycling and increased canopy complexity. Girdling-induced mortality of early successional species reduced soil respiration, accelerated fine root turnover, and prompted the redistribution of N from the foliage of early to later successional species. Nitrogen redistribution increased leaf area index (LAI) production by later successional species, offsetting declines in LAI from senescing early successional species. High rates of net primary production (NPP) were sustained in stands comprising a diverse assemblage of early and later successional species because later successional species, when already present in the canopy, rapidly compensated for declining growth of early successional species. Canopy structural complexity, which increased with forest age, was positively

  15. Electron Beam-Induced Conductivity Experiments in a Static Cell for Application to MHD Accelerators

    SciTech Connect

    Lipinski, Ronald L.; Nelson, Gordon L.; Pena, Gary E.; Reed, Kim W.

    1999-06-24

    Past analyses of conventional MHD accelerator systems, which employ arc heaters in conjunction with alkali metal seeding of the air, have concluded that this approach to acceleration of air is not capable of reaching the high total enthalpy, low temperatures, and high dynamic pressures required to support advanced engine testingl'2>3. The very high temperatures required to ionize the seed material, coupled with known limits on the maximum operating pressures attainable in arc heaters, dictate that the final entropy of the test gas will exceed the targeted test section value, resulting in test section pressures or Mach numbers which are too low. This was the basic conclusion of the NASA-sponsored MARIAH study3. The present work describes the fist phase of a planned multi-year experimental effort to demonstrate an alternative mode of MHD accelerator operation which can potentially obviate these limitations. The concept is to exploit the ionizing power of electron beams to create a nonequilibrium ionization condition in the MHD channel, thus greatly increasing the electrical conductivity compared to its thermodynamic equilibrium (essentially zero) value. The advantage of this mode of operation is that the static temperatures can be kept relatively low through the MHD channel. The paper summa rizes the theoretical model for electron beam ionization in air, recently developed by Macheret et a12. Experiments conducted at San&a National Laboratories for the purpose of validating this model are also described. The fust phase of these experiments consist of measuring the bulk electrical conductivity of static air in a confined volume in the vicinity of an energetic electron beam. The experimental method is described, preliminary data is presented, and the results are interpreted in the light of the theoretical model.

  16. Multi-Directional Sprinting and Acceleration Phase in Basketball and Handball Players Aged 14 and 15 Years.

    PubMed

    Popowczak, Marek; Rokita, Andrzej; Struzik, Artur; Cichy, Ireneusz; Dudkowski, Andrzej; Chmura, Paweł

    2016-10-01

    An important role in handball and basketball is played by ability to accelerate and ability to repeat multiple sprints. The aim of the study was to assess level of ability in multi-directional sprinting and running time over the first 5 m of the 30 m sprint in 93 basketball and handball players (46 boys and 47 girls) aged 14 to 15 years. The attempts were also made to find the relationships between the time of a 5-m run to evaluate initial acceleration phase and multi-directional sprinting evaluated using Five-Time Shuttle Run To Gates Test Statistical analysis revealed no important differences in times of 5-m runs and times of multi-directional sprinting between groups with different ages, genders, and sports specialties. Furthermore, no significant correlations were found based on Spearman's rank correlation coefficient between times of 5-m run and multi-directional sprinting in the most of subgroups studied.

  17. Test particle acceleration in a numerical MHD experiment of an anemone jet

    NASA Astrophysics Data System (ADS)

    Rosdahl, K. J.; Galsgaard, K.

    2010-02-01

    Aims: To use a 3D numerical MHD experiment representing magnetic flux emerging into an open field region as a background field for tracing charged particles. The interaction between the two flux systems generates a localised current sheet where MHD reconnection takes place. We investigate how efficiently the reconnection region accelerates charged particles and what kind of energy distribution they acquire. Methods: The particle tracing is done numerically using the Guiding Center Approximation on individual data sets from the numerical MHD experiment. Results: We derive particle and implied photon distribution functions having power law forms, and look at the impact patterns of particles hitting the photosphere. We find that particles reach energies far in excess of those seen in observations of solar flares. However the structure of the impact region in the photosphere gives a good representation of the topological structure of the magnetic field. Three movies are only available in electronic form at http://www.aanda.org

  18. Fusion-neutron measurements for magnetized liner inertial fusion experiments on the Z accelerator

    NASA Astrophysics Data System (ADS)

    Hahn, K. D.; Chandler, G. A.; Ruiz, C. L.; Cooper, G. W.; Gomez, M. R.; Slutz, S.; Sefkow, A. B.; Sinars, D. B.; Hansen, S. B.; Knapp, P. F.; Schmit, P. F.; Harding, E.; Jennings, C. A.; Awe, T. J.; Geissel, M.; Rovang, D. C.; Torres, J. A.; Bur, J. A.; Cuneo, M. E.; Glebov, V. Yu; Harvey-Thompson, A. J.; Herrman, M. C.; Hess, M. H.; Johns, O.; Jones, B.; Lamppa, D. C.; Lash, J. S.; Martin, M. R.; McBride, R. D.; Peterson, K. J.; Porter, J. L.; Reneker, J.; Robertson, G. K.; Rochau, G. A.; Savage, M. E.; Smith, I. C.; Styron, J. D.; Vesey, R. A.

    2016-05-01

    Several magnetized liner inertial fusion (MagLIF) experiments have been conducted on the Z accelerator at Sandia National Laboratories since late 2013. Measurements of the primary DD (2.45 MeV) neutrons for these experiments suggest that the neutron production is thermonuclear. Primary DD yields up to 3e12 with ion temperatures ∼2-3 keV have been achieved. Measurements of the secondary DT (14 MeV) neutrons indicate that the fuel is significantly magnetized. Measurements of down-scattered neutrons from the beryllium liner suggest ρRliner∼1g/cm2. Neutron bang times, estimated from neutron time-of-flight (nTOF) measurements, coincide with peak x-ray production. Plans to improve and expand the Z neutron diagnostic suite include neutron burn-history diagnostics, increased sensitivity and higher precision nTOF detectors, and neutron recoil-based yield and spectral measurements.

  19. Modelling third harmonic ion cyclotron acceleration of deuterium beams for JET fusion product studies experiments

    NASA Astrophysics Data System (ADS)

    Schneider, M.; Johnson, T.; Dumont, R.; Eriksson, J.; Eriksson, L.-G.; Giacomelli, L.; Girardo, J.-B.; Hellsten, T.; Khilkevitch, E.; Kiptily, V. G.; Koskela, T.; Mantsinen, M.; Nocente, M.; Salewski, M.; Sharapov, S. E.; Shevelev, A. E.; Contributors, JET

    2016-11-01

    Recent JET experiments have been dedicated to the studies of fusion reactions between deuterium (D) and Helium-3 (3He) ions using neutral beam injection (NBI) in synergy with third harmonic ion cyclotron radio-frequency heating (ICRH) of the beam. This scenario generates a fast ion deuterium tail enhancing DD and D3He fusion reactions. Modelling and measuring the fast deuterium tail accurately is essential for quantifying the fusion products. This paper presents the modelling of the D distribution function resulting from the NBI+ICRF heating scheme, reinforced by a comparison with dedicated JET fast ion diagnostics, showing an overall good agreement. Finally, a sawtooth activity for these experiments has been observed and interpreted using SPOT/RFOF simulations in the framework of Porcelli’s theoretical model, where NBI+ICRH accelerated ions are found to have a strong stabilizing effect, leading to monster sawteeth.

  20. Secular trend of the age at menarche of Japanese girls with special regard to the secular acceleration of the age at peak height velocity.

    PubMed

    Hoshi, H; Kouchi, M

    1981-12-01

    An attempt is made to clarify the special characteristics of the secular trend of the menarchial age in Japan. The relationships with the precocious appearance of the age at peak high velocity, another exemplification of the maturity acceleration, is also reviewed. This research on menarche was conducted in 1979-1980 on 284 school girls born between 1961 and 1966. The girls were healthy, of middle socioeconomic class, and grew up and lived in Tokyo and its outskirts. A questionnaire was given to each subject who was requested to answer after referring to her diary, mother's or sister's records, or any other writing about her menarche. If none of these was available, they were asked to provide an event which occurred soon before or after the menarche. The arithmetic mean of the age at menarche was 12.40 years with a range of 9.63 to 15.44 years. In 1958 research was conducted on the menarche of 309 girls in the same school, and the mean menarchial age was reported to be 13.27 years with a range of 10.83 to 16.92 years. The rate of acceleration during these 21 years was 4.4 months/decade. Mean menarchial ages obtained in 157 studies ever reported in Japan were plotted against the year of publication. No definite tendency was apparent until a gradual change toward earlier menstruation began in about 1920. In the next 20 years the average decreased from 15.0 to 14.2 years of age. The rate of decrease during the 1920-1940 period was about 4 months/decade. Due to World War 2, a retardation of menarche began in 1941 and reached a peak of about 15.0 years of age in 1950-1952, after which the trend changed into one of rapid acceleration. It is believed that the age at peak height velocity (PHV) is highly correlated with menarche age. The correlation coefficient is reported to be 0.71 by Nicholson and Hanly (1953), 0.93 by Deming (1957) and 0.77 by the author's of this study based on the present subjects. Thus it can be reasonably assumed that the secular trend of menarche

  1. Lifestyle-induced metabolic inflexibility and accelerated ageing syndrome: insulin resistance, friend or foe?

    PubMed Central

    Nunn, Alistair VW; Bell, Jimmy D; Guy, Geoffrey W

    2009-01-01

    determines functional longevity, a rather more descriptive term for the metabolic syndrome is the 'lifestyle-induced metabolic inflexibility and accelerated ageing syndrome'. Ultimately, thriftiness is good for us as long as we have hormetic stimuli; unfortunately, mankind is attempting to remove all hormetic (stressful) stimuli from his environment. PMID:19371409

  2. The effects of free and bonded sulfur both in the presence and absence of vulcanization accelerators on the rheological, technological, aging, and thermal stability of asphalts

    SciTech Connect

    Onabajo, A.; Kopsch, H.

    1987-01-01

    Rheological and technological experiments have been carried out on sulfur-modified asphalts in the temperature range of 353 K to 453 K over a wide range of shear rates (0-4800 sec/sup -1/). The results indicated that the activation energy of the viscous flow increased with increasing amount of bonded sulfur. The irreversible shear degradation observed in sulfur-modified asphalts is caused by the high shear forces which rupture the aggregated molecules. Thermogravimetric analysis and aging experiments on asphalts and their sulfurized products, containing varying amounts of free sulfur (0-5.5 wt.-%) and vulcanization accelerators (0.5-2.5 wt.-%), have shown that mixes containing vulcanization accelerators have higher thermal stabilities and are more resistant to thermal and non-thermal aging than the unaccelerated asphalt-sulfur mixed prepared at the same or higher temperatures. The changes in the rheological and physical properties of the mixes with time is not only explained by the changes in the physical state of unreacted free sulfur, that is, from plastic to crystalline state (physical process), but also attributable to the effect of chemical reactions.

  3. Physical processes at work in sub-30 fs, PW laser pulse-driven plasma accelerators: Towards GeV electron acceleration experiments at CILEX facility

    NASA Astrophysics Data System (ADS)

    Beck, A.; Kalmykov, S. Y.; Davoine, X.; Lifschitz, A.; Shadwick, B. A.; Malka, V.; Specka, A.

    2014-03-01

    Optimal regimes and physical processes at work are identified for the first round of laser wakefield acceleration experiments proposed at a future CILEX facility. The Apollon-10P CILEX laser, delivering fully compressed, near-PW-power pulses of sub-25 fs duration, is well suited for driving electron density wakes in the blowout regime in cm-length gas targets. Early destruction of the pulse (partly due to energy depletion) prevents electrons from reaching dephasing, limiting the energy gain to about 3 GeV. However, the optimal operating regimes, found with reduced and full three-dimensional particle-in-cell simulations, show high energy efficiency, with about 10% of incident pulse energy transferred to 3 GeV electron bunches with sub-5% energy spread, half-nC charge, and absolutely no low-energy background. This optimal acceleration occurs in 2 cm length plasmas of electron density below 1018 cm-3. Due to their high charge and low phase space volume, these multi-GeV bunches are tailor-made for staged acceleration planned in the framework of the CILEX project. The hallmarks of the optimal regime are electron self-injection at the early stage of laser pulse propagation, stable self-guiding of the pulse through the entire acceleration process, and no need for an external plasma channel. With the initial focal spot closely matched for the nonlinear self-guiding, the laser pulse stabilizes transversely within two Rayleigh lengths, preventing subsequent evolution of the accelerating bucket. This dynamics prevents continuous self-injection of background electrons, preserving low phase space volume of the bunch through the plasma. Near the end of propagation, an optical shock builds up in the pulse tail. This neither disrupts pulse propagation nor produces any noticeable low-energy background in the electron spectra, which is in striking contrast with most of existing GeV-scale acceleration experiments.

  4. Emotional experience improves with age: evidence based on over 10 years of experience sampling.

    PubMed

    Carstensen, Laura L; Turan, Bulent; Scheibe, Susanne; Ram, Nilam; Ersner-Hershfield, Hal; Samanez-Larkin, Gregory R; Brooks, Kathryn P; Nesselroade, John R

    2011-03-01

    Recent evidence suggests that emotional well-being improves from early adulthood to old age. This study used experience-sampling to examine the developmental course of emotional experience in a representative sample of adults spanning early to very late adulthood. Participants (N = 184, Wave 1; N = 191, Wave 2; N = 178, Wave 3) reported their emotional states at five randomly selected times each day for a one week period. Using a measurement burst design, the one-week sampling procedure was repeated five and then ten years later. Cross-sectional and growth curve analyses indicate that aging is associated with more positive overall emotional well-being, with greater emotional stability and with more complexity (as evidenced by greater co-occurrence of positive and negative emotions). These findings remained robust after accounting for other variables that may be related to emotional experience (personality, verbal fluency, physical health, and demographic variables). Finally, emotional experience predicted mortality; controlling for age, sex, and ethnicity, individuals who experienced relatively more positive than negative emotions in everyday life were more likely to have survived over a 13 year period. Findings are discussed in the theoretical context of socioemotional selectivity theory.

  5. Emotional experience improves with age: evidence based on over 10 years of experience sampling.

    PubMed

    Carstensen, Laura L; Turan, Bulent; Scheibe, Susanne; Ram, Nilam; Ersner-Hershfield, Hal; Samanez-Larkin, Gregory R; Brooks, Kathryn P; Nesselroade, John R

    2011-03-01

    Recent evidence suggests that emotional well-being improves from early adulthood to old age. This study used experience-sampling to examine the developmental course of emotional experience in a representative sample of adults spanning early to very late adulthood. Participants (N = 184, Wave 1; N = 191, Wave 2; N = 178, Wave 3) reported their emotional states at five randomly selected times each day for a one week period. Using a measurement burst design, the one-week sampling procedure was repeated five and then ten years later. Cross-sectional and growth curve analyses indicate that aging is associated with more positive overall emotional well-being, with greater emotional stability and with more complexity (as evidenced by greater co-occurrence of positive and negative emotions). These findings remained robust after accounting for other variables that may be related to emotional experience (personality, verbal fluency, physical health, and demographic variables). Finally, emotional experience predicted mortality; controlling for age, sex, and ethnicity, individuals who experienced relatively more positive than negative emotions in everyday life were more likely to have survived over a 13 year period. Findings are discussed in the theoretical context of socioemotional selectivity theory. PMID:20973600

  6. Emotional Experience Improves With Age: Evidence Based on Over 10 Years of Experience Sampling

    PubMed Central

    Carstensen, Laura L.; Turan, Bulent; Scheibe, Susanne; Ram, Nilam; Ersner-Hershfield, Hal; Samanez-Larkin, Gregory R.; Brooks, Kathryn P.; Nesselroade, John R.

    2012-01-01

    Recent evidence suggests that emotional well-being improves from early adulthood to old age. This study used experience-sampling to examine the developmental course of emotional experience in a representative sample of adults spanning early to very late adulthood. Participants (N = 184, Wave 1; N = 191, Wave 2; N = 178, Wave 3) reported their emotional states at five randomly selected times each day for a one week period. Using a measurement burst design, the one-week sampling procedure was repeated five and then ten years later. Cross-sectional and growth curve analyses indicate that aging is associated with more positive overall emotional well-being, with greater emotional stability and with more complexity (as evidenced by greater co-occurrence of positive and negative emotions). These findings remained robust after accounting for other variables that may be related to emotional experience (personality, verbal fluency, physical health, and demographic variables). Finally, emotional experience predicted mortality; controlling for age, sex, and ethnicity, individuals who experienced relatively more positive than negative emotions in everyday life were more likely to have survived over a 13 year period. Findings are discussed in the theoretical context of socioemotional selectivity theory. PMID:20973600

  7. U. S. -French Cooperative Research Program: U. S. test results for cable insulation and jacket materials at the completion of accelerated aging

    SciTech Connect

    Bustard, L.D.

    1984-01-01

    Eight different U.S. insulation and jacket products have been accelerated aged at Sandia. The experimental variables included: (1) sequential versus simultaneous accelerated aging exposures; (2) the order of the sequential exposures; and (3) ambient versus 70/sup 0/C irradiation temperatures during sequential aging exposures. We observed that the irradiation temperature (70/sup 0/C or ambient) was secondary in importance to the choice of sequence for thermal and radiation aging. For most materials studied (except TEFZEL) the irradiation then thermal aging sequence was as severe or more severe than the thermal then irradiation aging sequence.

  8. Evolution of the microstructure of unmodified and polymer modified asphalt binders with aging in an accelerated weathering tester.

    PubMed

    Menapace, Ilaria; Masad, Eyad

    2016-09-01

    This paper presents findings on the evolution of the surface microstructure of two asphalt binders, one unmodified and one polymer modified, directly exposed to aging agents with increasing durations. The aging is performed using an accelerated weathering tester, where ultraviolet radiation, oxygen and an increased temperature are applied to the asphalt binder surface. Ultraviolet and dark cycles, which simulated the succession of day and night, alternated during the aging process, and also the temperature varied, which corresponded to typical summer day and night temperatures registered in the state of Qatar. Direct aging of an exposed binder surface is more effective in showing microstructural modifications than previously applied protocols, which involved the heat treatment of binders previously aged with standardized methods. With the new protocol, any molecular rearrangements in the binder surface after aging induced by the heat treatment is prevented. Optical photos show the rippling and degradation of the binder surface due to aging. Microstructure images obtained by means of atomic force microscopy show gradual alteration of the surface due to aging. The original relatively flat microstructure was substituted with a profoundly different microstructure, which significantly protrudes from the surface, and is characterized by various shapes, such as rods, round structures and finally 'flower' or 'leaf' structures. PMID:27059404

  9. Evolution of the microstructure of unmodified and polymer modified asphalt binders with aging in an accelerated weathering tester.

    PubMed

    Menapace, Ilaria; Masad, Eyad

    2016-09-01

    This paper presents findings on the evolution of the surface microstructure of two asphalt binders, one unmodified and one polymer modified, directly exposed to aging agents with increasing durations. The aging is performed using an accelerated weathering tester, where ultraviolet radiation, oxygen and an increased temperature are applied to the asphalt binder surface. Ultraviolet and dark cycles, which simulated the succession of day and night, alternated during the aging process, and also the temperature varied, which corresponded to typical summer day and night temperatures registered in the state of Qatar. Direct aging of an exposed binder surface is more effective in showing microstructural modifications than previously applied protocols, which involved the heat treatment of binders previously aged with standardized methods. With the new protocol, any molecular rearrangements in the binder surface after aging induced by the heat treatment is prevented. Optical photos show the rippling and degradation of the binder surface due to aging. Microstructure images obtained by means of atomic force microscopy show gradual alteration of the surface due to aging. The original relatively flat microstructure was substituted with a profoundly different microstructure, which significantly protrudes from the surface, and is characterized by various shapes, such as rods, round structures and finally 'flower' or 'leaf' structures.

  10. Statistical comparison between experiments and numerical simulations of shock-accelerated gas cylinders

    SciTech Connect

    Rider, William; Kamm, J. R.; Zoldi, C. A.; Tomkins, C. D.

    2002-01-01

    We present detailed spatial analysis comparing experimental data and numerical simulation results for Richtmyer-Meshkov instability experiments of Prestridge et al. and Tomkins et al. These experiments consist, respectively, of one and two diffuse cylinders of sulphur hexafluoride (SF{sub 6}) impulsively accelerated by a Mach 1.2 shockwave in air. The subsequent fluid evolution and mixing is driven by the deposition of baroclinic vorticity at the interface between the two fluids. Numerical simulations of these experiments are performed with three different versions of high resolution finite volume Godunov methods, including a new weighted adaptive Runge-Kutta (WARK) scheme. We quantify the nature of the mixing using using integral measures as well as fractal analysis and continuous wavelet transforms. Our investigation of the gas cylinder configurations follows the path of our earlier studies of the geometrically and dynamically more complex gas 'curtain' experiment. In those studies, we found significant discrepancies in the details of the experimentally measured mixing and the details of the numerical simulations. Here we evaluate the effects of these hydrodynamic integration techniques on the diffuse gas cylinder simulations, which we quantitatively compare with experimental data.

  11. ISSLS PRIZE WINNER: INHIBITION OF NF-κB ACTIVITY AMELIORATES AGE-ASSOCIATED DISC DEGENERATION IN A MOUSE MODEL OF ACCELERATED AGING

    PubMed Central

    Nasto, Luigi A.; Seo, Hyoung-Yeon; Robinson, Andria R.; Tilstra, Jeremy S.; Clauson, Cheryl L.; Sowa, Gwendolyn A.; Ngo, Kevin; Dong, Qing; Pola, Enrico; Lee, Joon Y.; Niedernhofer, Laura J.; Kang, James D.; Robbins, Paul D.; Vo, Nam V.

    2012-01-01

    Study Design NF-κB activity was pharmacologically and genetically blocked in an accelerated aging mouse model to mitigate age-related disc degenerative changes. Objective To study the mediatory role of NF-κB signaling pathway in age-dependent intervertebral disc degeneration. Summary of Background Data Aging is a major contributor to intervertebral disc degeneration (IDD), but the molecular mechanism behind this process is poorly understood. NF-κB is a family of transcription factors which play a central role in mediating cellular response to damage, stress, and inflammation. Growing evidence implicates chronic NF-κB activation as a culprit in many aging-related diseases, but its role in aging-related IDD has not been adequately explored. We studied the effects of NF-κB inhibition on IDD using a DNA repair-deficient mouse model of accelerated aging (Ercc1-/Δ mice) previously been reported to exhibit age-related IDD. Methods Systemic inhibition of NF-κB activation was achieved either genetically by deletion of one allele of the NF-κB subunit p65 (Ercc1-/Δp65+/- mice) or pharmacologically by chronic intra-peritoneal administration of the Nemo Binding Domain (8K-NBD) peptide to block the formation of the upstream activator of NF-κB, IκB Inducible Kinase (IKK), in Ercc1-/Δ mice. Disc cellularity, total proteoglycan content and proteoglycan synthesis of treated mice and untreated controls were assessed. Results Decreased disc matrix proteoglycan content, a hallmark feature of IDD, and elevated disc NF-κB activity were observed in discs of progeroid Ercc1-/Δ mice and naturally aged wild-type compared to young WT mice. Systemic inhibition of NF-κB by the 8K-NBD peptide in Ercc1-/Δ mice increased disc proteoglycan synthesis and ameriolated loss disc cellularity and matrix proteoglycan. These results were confirmed genetically by using the p65 haploinsufficient Ercc1-/Δp65+/- mice. Conclusion These findings demonstrate that the IKK/NF-κB signaling pathway

  12. Experiments on 1,000 km/s flyer acceleration and collisions

    NASA Astrophysics Data System (ADS)

    Karasik, Max; Weaver, J. L.; Aglitskiy, Y.; Kehne, D. M.; Zalesak, S. T.; Velikovich, A. L.; Oh, J.; Serlin, V.; Obenschain, S. P.

    2012-10-01

    We will present results from follow-on experiments to the record-high velocities achieved using the ultra-uniform deep-uv drive of the Nike KrF laser [Karasik et al, Phys. Plasmas 17, 056317 (2010)], in which highly accelerated planar foils of deuterated polystyrene were made to collide with a witness foil to produce ˜1 Gbar shock pressures and result in heating of matter to thermonuclear temperatures. Such velocities may indicate a path to lower minimum energy required for central ignition. Still higher velocities and higher target densities are required for impact fast ignition. New results give velocity of >1,100 km/s achieved through improvements in pulseshaping. Variation of second foil parameters results in significant change in fusion neutron production on impact. In-flight target density is inferred from target heating upon collision via DD neutron time-of-flight ion temperature measurement. Availability of pressures generated by collisions of such highly accelerated flyers may provide an experimental platform for study of matter at extreme conditions. Work is supported by US DOE (NNSA).

  13. Laboratory Experiments with the Concordia College High-Speed Dust Particle Accelerator

    NASA Astrophysics Data System (ADS)

    Manning, H. L.

    2011-12-01

    During the Apollo Era, NASA's Goddard Space Flight Center built a 2MeV high-speed, dust particle accelerator. This facility was used to test and calibrate the LEAM instrument which was flown to the lunar surface by Apollo 17. As the Apollo project wound down, NASA no longer had need of the dust particle accelerator, and in 1975, it was move to Concordia College in Moorhead, MN. Through the years, it has been maintained and some modifications and improvements have been made to it. In the past decade, the facility has been revived and used by several collaborating institutions to study dust detector instrumentation as well as the effects of dust impacts on various materials. We have tested a prototype, space-flight dust particle detector. Also, piezoelectric pins which can be used as dust detectors were studied to learn the pin's response to single particle impacts of different energies and momenta, and then those measured responses were compared with theoretical models. The effects of high speed impacts on ultra-high temperature ceramics, aerogel, and several different thin films have also been studied at our facility. The results of these experiments will be presented.

  14. Features of accelerated electron beam formation in LHCD experiments on FT-2 tokamak

    NASA Astrophysics Data System (ADS)

    Lashkul, S. I.; Rozhdestvensky, V. V.; Altukhov, A. B.; Dyachenko, V. V.; Esipov, L. A.; Kantor, M. Yu.; Krikunov, S. V.; Kuprienko, D. V.; Stepanov, A. Yu.

    2012-12-01

    In experiments with lower hybrid current drive (LHCD) on the FT-2 tokamak, lower hybrid (LH) waves have been successfully used for the first time to ensure effective additional heating of plasma electrons from 450 to 600 eV ( I Pl = 32 kA, Δ t RF = 14 ms, P RF = 100 kW, F = 920 MHz). Several factors influencing the efficiency of plasma heating have been discovered. In particular, significant growth of radiation losses in the LHCD regime has been found, which is probably related to an increase in the intensity of synchrotron radiation from accelerated electrons. The increase in this intensity in the 53-156 GHz frequency range was accompanied by short spikes of microwave radiation, which were observed only in a narrower frequency range (53-78 GHz) and apparently resulted from interaction of a runaway electron beam with significant local mirrors of toroidal magnetic field. A model of the additional heating of plasma electrons due to absorption of the microwave radiation generated by a beam of accelerated electrons is proposed.

  15. Participation in the definition, conduct, and analysis of particle accelerator experiments for the first Spacelab Mission

    NASA Technical Reports Server (NTRS)

    Burch, J. L.

    1994-01-01

    The Space Experiments with Particle Accelerators (SEPAC) is a joint endeavor between NASA and the Institute of Space and Aeronautical Sciences (ISAS) in Japan. Its objectives are to use energetic electron beams to investigate beam-atmosphere interactions and beam-plasma interactions in the earth's upper atmosphere and ionosphere using the shuttle Spacelab. Two flights of SEPAC have occurred to date (Spacelab 1 on STS-9 in Nov.-Dec. 1983 and ATLAS 1 on STS-45 in Mar.-Apr. 1992). The SEPAC instrumentation is available for future missions, and the scientific results of the first two missions justify further investigations; however, at present there are no identifiable future flight opportunities. As specified in the contract, the primary purpose of this report is to review the scientific accomplishments of the ATLAS 1 SEPAC experiments, which have been documented in the published literature, with only a brief review of the earlier Spacelab 1 results. One of the main results of the Spacelab 1 SEPAC experiments was that the ejection of plasma from the magnetoplasmadynamic (MPD) arcjet was effective in maintaining vehicle charge neutralization during electron beam firings, but only for a brief period of 10 ms or so. Therefore, a xenon plasma contactor, which can provide continuous vehicle charge neutralization, was developed for the ATLAS 1 SEPAC experiments. Because of the successful operation of the plasma contactor on ATLAS 1, it was possible to perform experiments on beam-plasma interactions and beam-atmosphere interactions at the highest beam power levels of SEPAC. In addition, the ability of the plasma contactor to eject neutral xenon led to a successful experiment on the critical ionization velocity (CIV) phenomena on ATLAS 1.

  16. Deficiency in Poly(ADP-ribose) Polymerase-1 (PARP-1) Accelerates Aging and Spontaneous Carcinogenesis in Mice

    PubMed Central

    Piskunova, Tatiana S.; Yurova, Maria N.; Ovsyannikov, Anton I.; Semenchenko, Anna V.; Zabezhinski, Mark A.; Popovich, Irina G.; Wang, Zhao-Qi; Anisimov, Vladimir N.

    2008-01-01

    Genetic and biochemical studies have shown that PARP-1 and poly(ADP-ribosyl)ation play an important role in DNA repair, genomic stability, cell death, inflammation, telomere maintenance, and suppressing tumorigenesis, suggesting that the homeostasis of poly(ADP-ribosyl)ation and PARP-1 may also play an important role in aging. Here we show that PARP-1−/− mice exhibit a reduction of life span and a significant increase of population aging rate. Analysis of noninvasive parameters, including body weight gain, body temperature, estrous function, behavior, and a number of biochemical indices suggests the acceleration of biological aging in PARP-1−/− mice. The incidence of spontaneous tumors in both PARP-1−/− and PARP-1+/+ groups is similar; however, malignant tumors including uterine tumors, lung adenocarcinomas and hepatocellular carcinomas, develop at a significantly higher frequency in PARP-1−/− mice than PARP-1+/+ mice (72% and 49%, resp.; P < .05). In addition, spontaneous tumors appear earlier in PARP-1−/− mice compared to the wild type group. Histopathological studies revealed a wide spectrum of tumors in uterus, ovaries, liver, lungs, mammary gland, soft tissues, and lymphoid organs in both groups of the mice. These results demonstrate that inactivation of DNA repair gene PARP-1 in mice leads to acceleration of aging, shortened life span, and increased spontaneous carcinogenesis. PMID:19415146

  17. Age-related acceleration of endothelial dysfunction and subclinical atherosclerosis in subjects with coronary artery lesions after Kawasaki disease.

    PubMed

    Noto, Nobutaka; Okada, Tomoo; Karasawa, Kensuke; Ayusawa, Mamoru; Sumitomo, Naokata; Harada, Kensuke; Mugishima, Hideo

    2009-04-01

    The objective of this study was to test the hypothesis that accelerated endothelial dysfunction and the development of premature atherosclerosis are associated with age in subjects with coronary artery lesions after Kawasaki disease (KD). A case-control study was performed at a university hospital that included 35 post-KD subjects across a wide age range (range, 8-42 years) without traditional cardiovascular risk factors and 35 age- and sex-matched healthy control subjects (Cont). Flow-mediated dilatation (FMD) of the brachial artery-induced by reactive hyperemia, intima media thickness (IMT), and elastic modulus (Ep) of the common carotid artery were compared between KD and Cont subjects assessed against age. KD subjects had slightly higher levels of body mass index, lipid profile, and HbA1c than Cont subjects, but the differences were not significant. The mean IMT (p < 0.001), age-adjusted percentage normal IMT (%N IMT; p < 0.0001), and Ep (p < 0.001) were significantly higher in KD than Cont subjects, and the peak FMD% (p < 0.01) was significantly lower in KD than Cont subjects. There were significant correlations between FMD% and age (r = -0.51 p < 0.0001), IMT and age (r = 0.68, p < 0.001), and Ep and age (r = 0.58, p < 0.01) in KD but not Cont subjects. When the difference in FMD% between KD and matched Cont subjects (DeltaFMD%) was plotted against age, no significant relationship was found, although significant correlations between DeltaIMT and age (r = 0.52, p < 0.01) as well as between DeltaEp and age (r = 0.46, p < 0.05) were observed. When we defined values that were +2.0 SD over the mean control values (i.e., %N IMT >or= 120% and/or Ep >or= 50 kPa) as markers of subclinical atherosclerosis, 15 subjects met the criteria. Subjects over the age of 22 years were more likely to have (OR = 16.54, p = 0.0001) subclinical atherosclerosis in this cohort. Our results suggest that endothelial dysfunction and the development of premature atherosclerosis were

  18. Reliability and Failure Modes of Solid-State Lighting Electrical Drivers Subjected to Accelerated Aging

    SciTech Connect

    Lall, Pradeep; Sakalaukus, Peter; Davis, Lynn

    2015-02-19

    An investigation of an off-the-shelf solid-state lighting device with the primary focus on the accompanied light-emitting diode (LED) electrical driver (ED) has been conducted. A set of 10 EDs were exposed to temperature humidity life testing of 85% RH and 85 C (85/85) without an electrical bias per the JEDEC standard JESD22-A101C in order to accelerate the ingress of moisture into the aluminum electrolytic capacitor (AEC) and the EDs in order to assess the reliability of the LED drivers for harsh environment applications. The capacitance and equivalent series resistance for each AEC inside the ED were measured using a handheld LCR meter as possible leading indications of failure. The photometric quantities of a single pristine light engine were monitored in order to investigate the interaction between the light engine and the EDs. These parameters were used in assessing the overall reliability of the EDs. In addition, a comparative analysis has been conducted between the 85/85 accelerated test data and a previously published high-temperature storage life accelerated test of 135°C. The results of the 85/85 acceleration test and the comparative analysis are presented in this paper.

  19. Reliability and Failure Modes of Solid-State Lighting Electrical Drivers Subjected to Accelerated Aging

    DOE PAGES

    Lall, Pradeep; Sakalaukus, Peter; Davis, Lynn

    2015-02-19

    An investigation of an off-the-shelf solid-state lighting device with the primary focus on the accompanied light-emitting diode (LED) electrical driver (ED) has been conducted. A set of 10 EDs were exposed to temperature humidity life testing of 85% RH and 85 C (85/85) without an electrical bias per the JEDEC standard JESD22-A101C in order to accelerate the ingress of moisture into the aluminum electrolytic capacitor (AEC) and the EDs in order to assess the reliability of the LED drivers for harsh environment applications. The capacitance and equivalent series resistance for each AEC inside the ED were measured using a handheldmore » LCR meter as possible leading indications of failure. The photometric quantities of a single pristine light engine were monitored in order to investigate the interaction between the light engine and the EDs. These parameters were used in assessing the overall reliability of the EDs. In addition, a comparative analysis has been conducted between the 85/85 accelerated test data and a previously published high-temperature storage life accelerated test of 135°C. The results of the 85/85 acceleration test and the comparative analysis are presented in this paper.« less

  20. Extreme ultraviolet diagnostics of preformed plasma in laser-driven proton acceleration experiments

    SciTech Connect

    Ragozin, Eugene N.; Pirozhkov, Alexander S.; Yogo, Akifumi; Ma Jinglong; Ogura, Koichi; Orimo, Satoshi; Sagisaka, Akito; Mori, Michiaki; Li, Zhong; Nishiuchi, Mamiko; Daido, Hiroyuki

    2006-12-15

    Proton acceleration experiments involving a 5 {mu}m thick Ti foil target irradiation are carried out with the femtosecond Ti:sapphire laser JLITE-X. The plasma emission at 13.5 nm is recorded employing concave multilayer mirrors, which image the front- and rear-side plasmas onto the sensitive surfaces of a fast x-ray photodiode and a backside-illuminated charge coupled device. Online time-of-flight fast-particle measurements are performed simultaneously with the extreme ultraviolet (XUV) measurements. A strong correlation is observed between the energetic proton signal and the spatiotemporal behavior of the XUV plasma emission. In particular, the longer duration of the prepulse-produced XUV plasma emission indicates a lowering of the maximum proton energy. This allows using the XUV emission for the diagnostics of the high-intensity laser-solid-target interaction.

  1. Colliding pulse injection experiments in non-collinear geometryfor controlled laser plasma wakefield acceleration of electrons

    SciTech Connect

    Toth, Carl B.; Esarey, Eric H.; Geddes, Cameron G.R.; Leemans,Wim P.; Nakamura, Kei; Panasenko, Dmitriy; Schroeder, Carl B.; Bruhwiler,D.; Cary, J.R.

    2007-06-25

    An optical injection scheme for a laser-plasma basedaccelerator which employs a non-collinear counter-propagating laser beamto push background electrons in the focusing and acceleration phase viaponderomotive beat with the trailing part of the wakefield driver pulseis discussed. Preliminary experiments were performed using a drive beamof a_0 = 2.6 and colliding beam of a_1 = 0.8 both focused on the middleof a 200 mu m slit jet backed with 20 bar, which provided ~; 260 mu mlong gas plume. The enhancement in the total charge by the collidingpulse was observed with sharp dependence on the delay time of thecolliding beam. Enhancement of the neutron yield was also measured, whichsuggests a generation of electrons above 10 MeV.

  2. Accelerator Technology and High Energy Physics Experiments, Photonics Applications and Web Engineering, Wilga, May 2012

    NASA Astrophysics Data System (ADS)

    Romaniuk, Ryszard S.

    2012-05-01

    The paper is the second part (out of five) of the research survey of WILGA Symposium work, May 2012 Edition, concerned with accelerator technology and high energy physics experiments. It presents a digest of chosen technical work results shown by young researchers from different technical universities from this country during the XXXth Jubilee SPIE-IEEE Wilga 2012, May Edition, symposium on Photonics and Web Engineering. Topical tracks of the symposium embraced, among others, nanomaterials and nanotechnologies for photonics, sensory and nonlinear optical fibers, object oriented design of hardware, photonic metrology, optoelectronics and photonics applications, photonicselectronics co-design, optoelectronic and electronic systems for astronomy and high energy physics experiments, JET and pi-of-the sky experiments development. The symposium is an annual summary in the development of numerable Ph.D. theses carried out in this country in the area of advanced electronic and photonic systems. It is also a great occasion for SPIE, IEEE, OSA and PSP students to meet together in a large group spanning the whole country with guests from this part of Europe. A digest of Wilga references is presented [1-275].

  3. Synergy Between Experiments and Simulations in Laser and Beam-Driven Plasma Acceleration and Light Sources

    NASA Astrophysics Data System (ADS)

    Mori, Warren B.

    2015-11-01

    Computer simulations have been an integral part of plasma physics research since the early 1960s. Initially, they provided the ability to confirm and test linear and nonlinear theories in one-dimension. As simulation capabilities and computational power improved, then simulations were also used to test new ideas and applications of plasmas in multi-dimensions. As progress continued, simulations were also used to model experiments. Today computer simulations of plasmas are ubiquitously used to test new theories, understand complicated nonlinear phenomenon, model the full temporal and spatial scale of experiments, simulate parameters beyond the reach of current experiments, and test the performance of new devices before large capital expenditures are made to build them. In this talk I review the progress in simulations in a particular area of plasma physics: plasma based acceleration (PBA). In PBA a short laser pulse or particle beam propagates through long regions of plasma creating plasma wave wakefields on which electrons or positrons surf to high energies. In some cases the wakefields are highly nonlinear, involve three-dimensional effects, and the trajectories of plasma particles cross making it essential that fully kinetic and three-dimensional models are used. I will show how particle-in-cell (PIC) simulations were initially used to propose the basic idea of PBA in one dimension. I will review some of the dramatic progress in the experimental demonstration of PBA and show how this progress was dramatically helped by a synergy between experiments and full-scale multi-dimensional PIC simulations. This will include a review of how the capability of PIC simulation tools has improved. I will also touch on some recent progress on improvements to PIC simulations of PBA and discuss how these improvements may push the synergy further towards real time steering of experiments and start to end modeling of key components of a future linear collider or XFEL based on PBA

  4. Accelerated wound closure of pressure ulcers in aged mice by chitosan scaffolds with and without bFGF.

    PubMed

    Park, Chan J; Clark, Sherrie G; Lichtensteiger, Carol A; Jamison, Russell D; Johnson, Amy J Wagoner

    2009-07-01

    Pressure ulcers are a significant healthcare concern, especially for elderly populations. Our work served to ameliorate the chronicity of these ulcers by addressing ischemia-reperfusion injury mediated by neutrophils and the concomitant loss of vasculature in these wounds. To this end, chitosan scaffolds loaded with basic fibroblast growth factor (bFGF) contained in gelatin microparticles were developed and tested for clinical relevance in an aged mouse model. Pressure ulcers were induced in aged mice, and efficacy of treatment was assessed. On days 3 and 7, both chitosan and chitosan-bFGF scaffolds significantly accelerated wound closure compared to gauze control. By day 10, all wounds achieved similar closure. Delivery and angiogenic function of bFGF was verified through ELISA and histology. Elevated neutrophil levels were observed in chitosan and chitosan-bFGF groups. Since neutrophil elastase contributes to the proteolytic environments of pressure ulcers, the effect of chitosan on elastase was assessed. In vitro, chitosan inhibited elastase activity. In vivo, elastase protein levels in wounds were reduced with chitosan-bFGF scaffolds by day 10. These results suggest that chitosan is an effective material for growth factor delivery and can help to heal chronic ulcers. Collectively, our data show that chitosan-bFGF scaffolds are effective in accelerating wound closure of pressure ulcers in aged animals.

  5. Analysis of tetragonal to monoclinic phase transformation caused by accelerated artificial aging and the effects of microstructure in stabilized zirconia

    NASA Astrophysics Data System (ADS)

    Lucas, Thomas J.

    This investigation addresses the issue that yttria stabilized zirconia is being used as a dental biomaterial without substantial evidence of its long-term viability. Furthermore, stabilized zirconia (SZ) undergoes low temperature degradation (LTD), which can lead to roughening of the surface. A rougher exterior can lead to increased wear of the antagonist in the oral environment. Despite the LTD concerns, SZ is now widely used in restorative dentistry, including full contour crowns. A comparison of aging methods to determine the role of artificial aging on inducing the transformation has not been extensively studied. Therefore, simulations of the transformation process were investigated by comparing different methods of accelerated aging. The rejected null hypothesis is that the temperature of aging treatment will not affect the time required to cause measurable monoclinic transformation of yttria stabilized zirconia. The transformation of SZ starts at the surface and progresses inward; however, it is unclear whether the progression is constant for different aging conditions. This investigation analyzed the depth of transformation as a function of aging conditions for stabilized zirconia in the top 5-6 mum from the surface. The rejected null hypothesis is that the transformation amount is constant throughout the first six micrometers from the surface. The effects of grain size on the amount of monoclinic transformation were also investigated. This study aimed to determine if the grain size of partially stabilized zirconia affects the amount of monoclinic transformation, surface roughness, and property degradation due to aging. The rejected null hypothesis is that the grain size will not affect the amount of monoclinic transformation, thus have no effect on surface roughening or property degradation. The final part of this study addresses the wear of enamel when opposing zirconia by observing how grain size and aging affected the wear rate of an enamel antagonist

  6. Fractography evolution in accelerated aging of UHMWPE after gamma irradiation in air.

    PubMed

    Medel, F; Gómez-Barrena, E; García-Alvarez, F; Ríos, R; Gracia-Villa, L; Puértolas, J A

    2004-01-01

    We studied the fracture surface evolution of ultra high molecular weight polyethylene (UHMWPE) specimens, manufactured from GUR 1050 compression moulded sheets, after gamma sterilisation in air followed by different aging times after thermal treatment at 120 degrees C. Degradation profiles were obtained by FTIR and DSC measurements after 0, 7, 14, 24 and 36h aging. We observed by SEM the morphology patterns at these aging times, in surface fractographies after uniaxial tensile test of standardised samples. The results pointed out clear differences between short and long aging times. At shorter times, 7h, the behaviour was similar to non-degraded UHMWPE, exhibiting ductile behaviour. At longer times, 24-36h, this thermal protocol provided a highly degraded zone in the subsurface, similar to the white band found after gamma irradiation in air followed by natural aging, although closer to the surface, at 150-200mum. The microstructure of this oxidation zone, similarly found in gamma irradiated samples shelf-aged for 6-7 years, although with different distribution of microvoids, was formed by fibrils, associated with embrittlement of the oxidised UHMWPE. In addition, the evolution of the oxidation index, the enthalpy content, the mechanical parameters, and the depth of the oxidation front deduced from the fractographies versus aging time showed that a changing behaviour in the degradation rate appeared at intermediate aging times.

  7. The Associative Changes in Scutellum Nuclear Content and Morphology with Viability Loss of Naturally Aged and Accelerated Aging Wheat (Triticum aestivum) Seeds

    PubMed Central

    Ahmed, Zaheer; Yang, Hui; Fu, Yong-Bi

    2016-01-01

    Timely prediction of seed viability loss over long-term storage represents a challenge in management and conservation of ex situ plant genetic resources. However, little attention has been paid to study the process of seed deterioration and seed aging signals under storage. An attempt was made here to investigate morphological and molecular changes in the scutellum and aleurone sections of naturally or artificially aged wheat seeds using TUNEL assay and DAPI staining. Twelve wheat genotypes or samples exposed to natural ageing (NA) or accelerated ageing (AA) were assayed and these samples had germination rates ranging from 11 to 93%. The assayed samples showed substantial changes in scutellum, but not aleurone. The nuclei observed in the majority of the scutellum cells of the NA seed samples of lower germination rates were longer in size and less visible, while the scutellum cell morphology or arrangement remained unchanged. In contrast, longer AA treatments resulted in the loss of scutellum cell structure, collapse of cell layers, and disappearance of honey comb arrangements. These nuclei and structural changes were consistent with the DNA assessments of nuclear alternations for the selected wheat samples. Interestingly, the sample seed germination loss was found to be associated with the reductions in the scutellum nuclear content and with the increases in the scutellum nuclei length to width ratio. These findings are significant for understanding the process of wheat seed deterioration and are also useful for searching for sensitive seed aging signals for developing tools to monitor seed viability under storage. PMID:27729925

  8. Microstructural modifications induced by accelerated aging and lipid absorption in remelted and annealed UHMWPEs for total hip arthroplasty.

    PubMed

    Puppulin, Leonardo; Zhu, Wenliang; Sugano, Nobuhiko; Pezzotti, Giuseppe

    2015-01-01

    Three types of commercially available ultra-high molecular weight polyethylene (UHMWPE) acetabular cups currently used in total hip arthroplasty have been studied by means of Raman micro-spectroscopy to unfold the microstructural modification induced by the oxidative degradation after accelerated aging with and without lipid absorption. The three investigated materials were produced by three different manufacturing procedures, as follows: irradiation followed by remelting, one-step irradiation followed by annealing, 3-step irradiation and annealing. Clear microstructural differences were observed in terms of phase contents (i.e. amorphous, crystalline and intermediate phase fraction). The three-step annealed material showed the highest crystallinity fraction in the bulk, while the remelted polyethylene is clearly characterized by the lowest content of crystalline phase and the highest content of amorphous phase. After accelerated aging either with or without lipids, the amount of amorphous phase decreased in all the samples as a consequence of the oxidation-induced recrystallization. The most remarkable variations of phase contents were detected in the remelted and in the single-step annealed materials. The presence of lipids triggered oxidative degradation especially in the remelted polyethylene. Such experimental evidence might be explained by the highest amount of amorphous phase in which lipids can be absorbed prior to accelerated aging. The results of these spectroscopic characterizations help to rationalize the complex effect of different irradiation and post-irradiation treatments on the UHMWPE microstructure and gives useful information on how significantly any single step of the manufacturing procedures might affect the oxidative degradation of the polymer.

  9. Quantitative proteomics analysis of specific protein expression and oxidative modification in aged senescence-accelerated-prone 8 mice brain.

    PubMed

    Poon, H F; Castegna, A; Farr, S A; Thongboonkerd, V; Lynn, B C; Banks, W A; Morley, J E; Klein, J B; Butterfield, D A

    2004-01-01

    The senescence-accelerated mouse (SAM) is a murine model of accelerated senescence that was established using phenotypic selection. The SAMP series includes nine substrains, each of which exhibits characteristic disorders. SAMP8 is known to exhibit age-dependent learning and memory deficits. In our previous study, we reported that brains from 12-month-old SAMP8 have greater protein oxidation, as well as lipid peroxidation, compared with brains from 4-month-old SAMP8 mice. In order to investigate the relation between age-associated oxidative stress on specific protein oxidation and age-related learning and memory deficits in SAMP8, we used proteomics to identify proteins that are expressed differently and/or modified oxidatively in aged SAMP8 brains. We report here that in 12 month SAMP8 mice brains the expressions of neurofilament triplet L protein, lactate dehydrogenase 2 (LDH-2), heat shock protein 86, and alpha-spectrin are significantly decreased, while the expression of triosephosphate isomerase (TPI) is increased compared with 4-month-old SAMP8 brains. We also report that the specific protein carbonyl levels of LDH-2, dihydropyrimidinase-like protein 2, alpha-spectrin and creatine kinase, are significantly increased in the brain of 12-month-old SAMP8 mice when compared with the 4-month-old SAMP8 brain. These findings are discussed in reference to the effect of specific protein oxidation and changes of expression on potential mechanisms of abnormal alterations in metabolism and neurochemicals, as well as to the learning and memory deficits in aged SAMP8 mice.

  10. Fusion-neutron measurements for magnetized liner inertial fusion experiments on the Z accelerator

    DOE PAGES

    Hahn, K. D.; Chandler, G. A.; Ruiz, C. L.; Cooper, G. W.; Gomez, M. R.; Slutz, S.; Sefkow, A. B.; Sinars, D. B.; Hansen, S. B.; Knapp, P. F.; et al

    2016-05-01

    Several magnetized liner inertial fusion (MagLIF) experiments have been conducted on the Z accelerator at Sandia National Laboratories since late 2013. Measurements of the primary DD (2.45 MeV) neutrons for these experiments suggest that the neutron production is thermonuclear. Primary DD yields up to 3e12 with ion temperatures ~2-3 keV have been achieved. Measurements of the secondary DT (14 MeV) neutrons indicate that the fuel is significantly magnetized. Measurements of down-scattered neutrons from the beryllium liner suggest ρRliner ~ 1g/cm2. Neutron bang times, estimated from neutron time-of-flight (nTOF) measurements, coincide with peak x-ray production. Furthermore, plans to improve and expandmore » the Z neutron diagnostic suite include neutron burn-history diagnostics, increased sensitivity and higher precision nTOF detectors, and neutron recoil-based yield and spectral measurements.« less

  11. Reduced quality and accelerated follicle loss with female reproductive aging - does decline in theca dehydroepiandrosterone (DHEA) underlie the problem?

    PubMed Central

    2013-01-01

    Infertility, spontaneous abortion and conception of trisomic offspring increase exponentially with age in mammals but in women there is an apparent acceleration in the rate from about age 37. The problems mostly commonly occur when the ovarian pool of follicles is depleted to a critical level with age but are also found in low follicular reserve of other etiologies. Since recent clinical studies have indicated that dehydroepiandrosterone (DHEA) supplementation may reverse the problem of oocyte quality, this review of the literature was undertaken in an attempt to find an explanation of why this is effective? In affected ovaries, oxygenation of follicular fluid is low, ultrastructural disturbances especially of mitochondria, occur in granulosa cells and oocytes, and considerable disturbances of meiosis occur. There is, however, no evidence to date that primordial follicles are compromised. In females with normal fertility, pre-antral ovarian theca cells respond to stimulation by inhibin B to provide androgen-based support for the developing follicle. With depletion of follicle numbers, inhibin B is reduced with consequent reduction in theca DHEA. Theca cells are the sole ovarian site of synthesis of DHEA, which is both a precursor of androstenedione and an essential ligand for peroxisome proliferator-activated receptor alpha (PPARα), the key promoter of genes affecting fatty acid metabolism and fat transport and genes critical to mitochondrial function. As well as inducing a plethora of deleterious changes in follicular cytoplasmic structure and function, the omega 9 palmitate/oleate ratio is increased by lowered activity of PPARα. This provides conditions for increased ceramide synthesis and follicular loss through ceramide-induced apoptosis is accelerated. In humans critical theca DHEA synthesis occurs at about 70 days prior to ovulation thus effective supplementation needs to be undertaken about four months prior to intended conception; timing which is also

  12. High-Current Experiments for Accelerator-Based Neutron Capture Therapy Applications

    SciTech Connect

    Gierga, D.P.; Klinkowstein, R.E.; Hughey, B.H.; Shefer, R.E.; Yanch, J.C.; Blackburn, B.W.

    1999-06-06

    Several accelerator-based neutron capture therapy applications are under development. These applications include boron neutron capture therapy for glioblastoma multiform and boron neutron capture synovectomy (BNCS) for rheumatoid arthritis. These modalities use accelerator-based charged-particle reactions to create a suitable neutron source. Neutrons are produced using a high-current, 2-MV terminal tandem accelerator. For these applications to be feasible, high accelerator beam currents must be routinely achievable. An effort was undertaken to explore the operating regime of the accelerator in the milliampere range. In preparation for high-current operation of the accelerator, computer simulations of charged-particle beam optics were performed to establish high-current operating conditions. Herein we describe high beam current simulations and high beam current operation of the accelerator.

  13. Accelerated aging studies of UHMWPE. II. Virgin UHMWPE is not immune to oxidative degradation.

    PubMed

    Edidin, A A; Villarraga, M L; Herr, M P; Muth, J; Yau, S S; Kurtz, S M

    2002-08-01

    In Part I of this series, we showed that aging at elevated oxygen pressure is more successful at increasing the depth to which degradation occurs although it, too, generally causes greater degradation at the surface than at the subsurface. Therefore we hypothesized that thermal degradation alone, in the absence of free radicals, could be sufficient to artificially age UHMWPE in a manner analogous to natural aging. In the present study, virgin and air-irradiated UHMWPE (extruded GUR 1050 and compression-molded 1900) were aged up to 4 weeks at elevated oxygen pressure, and the mechanical behavior at the surface and subsurface was examined. All the materials were substantially degraded following 4 weeks of aging, but the spatial variations in the nonirradiated materials more closely mimicked the previously observed subsurface peak of degradation seen in naturally aged UHMWPE following irradiation in air. This aged material could provide a more realistic model for subsurface mechanical degradation, making it suitable for further mechanical testing in venues such as wear simulation.

  14. Accelerated aging phenotype in mice with conditional deficiency for mitochondrial superoxide dismutase in the connective tissue.

    PubMed

    Treiber, Nicolai; Maity, Pallab; Singh, Karmveer; Kohn, Matthias; Keist, Alexander F; Ferchiu, Florentina; Sante, Lea; Frese, Sebastian; Bloch, Wilhelm; Kreppel, Florian; Kochanek, Stefan; Sindrilaru, Anca; Iben, Sebastian; Högel, Josef; Ohnmacht, Michael; Claes, Lutz E; Ignatius, Anita; Chung, Jin H; Lee, Min J; Kamenisch, York; Berneburg, Mark; Nikolaus, Thorsten; Braunstein, Kerstin; Sperfeld, Anne-Dorte; Ludolph, Albert C; Briviba, Karlis; Wlaschek, Meinhard; Florin, Lore; Angel, Peter; Scharffetter-Kochanek, Karin

    2011-04-01

    The free radical theory of aging postulates that the production of mitochondrial reactive oxygen species is the major determinant of aging and lifespan. Its role in aging of the connective tissue has not yet been established, even though the incidence of aging-related disorders in connective tissue-rich organs is high, causing major disability in the elderly. We have now addressed this question experimentally by creating mice with conditional deficiency of the mitochondrial manganese superoxide dismutase in fibroblasts and other mesenchyme-derived cells of connective tissues in all organs. Here, we have shown for the first time that the connective tissue-specific lack of superoxide anion detoxification in the mitochondria results in reduced lifespan and premature onset of aging-related phenotypes such as weight loss, skin atrophy, kyphosis (curvature of the spine), osteoporosis and muscle degeneration in mutant mice. Increase in p16(INK4a) , a robust in vivo marker for fibroblast aging, may contribute to the observed phenotype. This novel model is particularly suited to decipher the underlying mechanisms and to develop hopefully novel connective tissue-specific anti-aging strategies.

  15. Shortened estrous cycle length, increased FSH levels, FSH variance, oocyte spindle aberrations, and early declining fertility in aging senescence-accelerated mouse prone-8 (SAMP8) mice: concomitant characteristics of human midlife female reproductive aging.

    PubMed

    Bernstein, Lori R; Mackenzie, Amelia C L; Kraemer, Duane C; Morley, John E; Farr, Susan; Chaffin, Charles L; Merchenthaler, István

    2014-06-01

    Women experience a series of specific transitions in their reproductive function with age. Shortening of the menstrual cycle begins in the mid to late 30s and is regarded as the first sign of reproductive aging. Other early changes include elevation and increased variance of serum FSH levels, increased incidences of oocyte spindle aberrations and aneuploidy, and declining fertility. The goal of this study was to investigate whether the mouse strain senescence-accelerated mouse-prone-8 (SAMP8) is a suitable model for the study of these midlife reproductive aging characteristics. Midlife SAMP8 mice aged 6.5-7.85 months (midlife SAMP8) exhibited shortened estrous cycles compared with SAMP8 mice aged 2-3 months (young SAMP8, P = .0040). Midlife SAMP8 mice had high FSH levels compared with young SAMP8 mice, and mice with a single day of high FSH exhibited statistically elevated FSH throughout the cycle, ranging from 1.8- to 3.6-fold elevation on the days of proestrus, estrus, metestrus, and diestrus (P < .05). Midlife SAMP8 mice displayed more variance in FSH than young SAMP8 mice (P = .01). Midlife SAMP8 ovulated fewer oocytes (P = .0155). SAMP8 oocytes stained with fluorescently labeled antitubulin antibodies and scored in fluorescence microscopy exhibited increased incidence of meiotic spindle aberrations with age, from 2/126 (1.59%) in young SAMP8 to 38/139 (27.3%) in midlife SAMP8 (17.2-fold increase, P < .0001). Finally, SAMP8 exhibited declining fertility from 8.9 pups/litter in young SAMP8 to 3.5 pups/litter in midlife SAMP8 mice (P < .0001). The age at which these changes occur is younger than for most mouse strains, and their simultaneous occurrence within a single strain has not been described previously. We propose that SAMP8 mice are a model of midlife human female reproductive aging.

  16. Ageing under mechanical stress: first experiments for a silver based multilayer mirror

    NASA Astrophysics Data System (ADS)

    Lalo, Arnaud; Ravel, Guillaume; Ignat, Michel; Cousin, Bernard; Swain, Michael V.

    2004-06-01

    Improving materials and devices reliability is a major concern to the spatial industry. Results are reported for satellite mirrors-like specimens consisting in oxide-protected metal systems. Optical coatings were deposited by electron beam evaporation. Mechanical stress fields in multi-layered materials play an important role. The stress state can have far-reaching implications both in kinetics and thermodynamics. Therefore an integrated apparatus with four-point bending equipment was designed. The technique allowed us to exert stress into a film or a system of films on a substrate concurrently with thermal treatment. In order to achieve the first tests performed with the help of the apparatus, various preliminary characterizations were required. The article reports the preliminary micro-mechanical testing of the materials (ultra micro-indentation to evaluate the elastic modulus of the samples materials and wafer curvature technique to determine the specimen residual stress) and the first ageing experiment. Experimental evidence of accelerated ageing under stress is successfully reported.

  17. Oxidative stress and age-related changes in T cells: is thalassemia a model of accelerated immune system aging?

    PubMed Central

    Ghatreh-Samani, Mahdi; Esmaeili, Nafiseh; Soleimani, Masoud; Asadi-Samani, Majid; Ghatreh-Samani, Keihan

    2016-01-01

    Iron overload in β-thalassemia major occurs mainly due to blood transfusion, an essential treatment for β-thalassemia major patients, which results in oxidative stress. It has been thought that oxidative stress causes elevation of immune system senescent cells. Under this condition, cells normally enhance in aging, which is referred to as premature immunosenescence. Because there is no animal model for immunosenescence, most knowledge on the immunosenescence pattern is based on induction of immunosenescence. In this review, we describe iron overload and oxidative stress in β-thalassemia major patients and how they make these patients a suitable human model for immunosenescence. We also consider oxidative stress in some kinds of chronic virus infections, which induce changes in the immune system similar to β-thalassemia major. In conclusion, a therapeutic approach used to improve the immune system in such chronic virus diseases, may change the immunosenescence state and make life conditions better for β-thalassemia major patients. PMID:27095931

  18. Oxidative stress and age-related changes in T cells: is thalassemia a model of accelerated immune system aging?

    PubMed

    Ghatreh-Samani, Mahdi; Esmaeili, Nafiseh; Soleimani, Masoud; Asadi-Samani, Majid; Ghatreh-Samani, Keihan; Shirzad, Hedayatolah

    2016-01-01

    Iron overload in β-thalassemia major occurs mainly due to blood transfusion, an essential treatment for β-thalassemia major patients, which results in oxidative stress. It has been thought that oxidative stress causes elevation of immune system senescent cells. Under this condition, cells normally enhance in aging, which is referred to as premature immunosenescence. Because there is no animal model for immunosenescence, most knowledge on the immunosenescence pattern is based on induction of immunosenescence. In this review, we describe iron overload and oxidative stress in β-thalassemia major patients and how they make these patients a suitable human model for immunosenescence. We also consider oxidative stress in some kinds of chronic virus infections, which induce changes in the immune system similar to β-thalassemia major. In conclusion, a therapeutic approach used to improve the immune system in such chronic virus diseases, may change the immunosenescence state and make life conditions better for β-thalassemia major patients.

  19. Analysis of Density Changes in Plutonium Observed from Accelerated Aging Using Pu-238 Enrichment

    SciTech Connect

    Chung, B W; Saw, C K; Thompson, S R; Quick, T M; Woods, C H; Hopkins, D J; Ebbinghaus, B B

    2006-07-11

    We present dimensional and density changes in an aging plutonium alloy enriched with 7.3 at.% of {sup 238}Pu and reference alloys of various ages. After 45 equivalent years of aging, the enriched alloys at 35 C have swelled in volume by 0.14 to 0.16% and now exhibit a near linear volume increase, without void swelling. Based on X-ray diffraction measurements, the lattice expansion by self-irradiation appears to be the primary cause for dimensional changes during the initial 2-3 years of aging. Following the initial transient, the density change is primarily cause by a constant helium in-growth rate as a result of {alpha}-particle decay.

  20. Ethylene propylene cable degradation during LOCA research tests: tensile properties at the completion of accelerated aging

    SciTech Connect

    Bustard, L.D.

    1982-05-01

    Six ethylene-propylene rubber (EPR) insulation materials were aged at elevated temperature and radiation stress exposures common in cable LOCA qualification tests. Material samples were subjected to various simultaneous and sequential aging simulations in preparation for accident environmental exposures. Tensile properties subsequent to the aging exposure sequences are reported. The tensile properties of some, but not all, specimens were sensitive to the order of radiation and elevated temperature stress exposure. Other specimens showed more severe degradation when simultaneously exposed to radiation and elevated temperature as opposed to the sequential exposure to the same stresses. Results illustrate the difficulty in defining a single test procedure for nuclear safety-related qualification of EPR elastomers. A common worst-case sequential aging sequence could not be identified.

  1. Free radical entrapment and crystallinity of resin composites after accelerated aging as a function of the expiration date.

    PubMed

    D'Alpino, Paulo Henrique Perlatti; Vismara, Marcos Vinícius Gonçalves; González, Alejandra Hortencia Miranda; Graeff, Carlos Frederico de Oliveira

    2014-08-01

    This study evaluated the spin concentration and the crystallinity in different classifications of dental composites as a function of the material condition (new, aged and expired). Specimens were obtained according to the factors: composites: Filtek P60, Filtek Z250, Filtek Z350XT, and Filtek Silorane; and material conditions: new, aged, and expired. The syringe composites underwent an accelerated aging protocol (Arrhenius model). The magnetic properties of the composites were characterized using Electron Paramagnetic Resonance (EPR) and the concentration of spins (number of spins/mass) was calculated. The crystallinity of the composites tested was characterized with X-ray diffraction (XRD). Filtek P60 and Filtek Z250 presented similarities in terms of spin concentration and crystallinity, irrespective of the material condition. The aging protocol influenced the composite Filtek Z350XT that exhibited a significant increase in the spin concentration. Besides, lower intensity peaks of the organic matrix and amorphous silica were also observed for both aged and expired Filtek Z350XT. Although a significant lower spin concentration was observed for the silorane composite in comparison to that of the methacrylates, a decrease in the relative intensity of peaks of the amorphous region related to the organic components in the diffractograms was observed. The material conditions tested influence the crystallinity and the magnetic properties of the composites evaluated.

  2. Modulation of the phenolic composition and colour of red wines subjected to accelerated ageing by controlling process variables.

    PubMed

    González-Sáiz, J M; Esteban-Díez, I; Rodríguez-Tecedor, S; Pérez-Del-Notario, N; Arenzana-Rámila, I; Pizarro, C

    2014-12-15

    The aim of the present work was to evaluate the effect of the main factors conditioning accelerated ageing processes (oxygen dose, chip dose, wood origin, toasting degree and maceration time) on the phenolic and chromatic profiles of red wines by using a multivariate strategy based on experimental design methodology. The results obtained revealed that the concentrations of monomeric anthocyanins and flavan-3-ols could be modified through the application of particular experimental conditions. This fact was particularly remarkable since changes in phenolic profile were closely linked to changes observed in chromatic parameters. The main strength of this study lies in the possibility of using its conclusions as a basis to make wines with specific colour properties based on quality criteria. To our knowledge, the influence of such a large number of alternative ageing parameters on wine phenolic composition and chromatic attributes has not been studied previously using a comprehensive experimental design methodology.

  3. Bragg Resonator Cyclotron Resonance Maser Experiments Driven by a Microsecond, Intense Electron Beam Accelerator

    NASA Astrophysics Data System (ADS)

    Choi, Jin Joo

    The cyclotron resonance maser (CRM) has proven to be attractive for many high power microwave applications such as fusion plasma heating, radar/communications, and high gradient RF accelerators. Most of the previous CRM experiments with MV electron beams have been conducted with short (<0.1 musec) pulses. The present work contains the first comprehensive experimental study on mode competition in a high-Q Bragg resonator CRM employing a microsecond, relativistic electron beam. We have designed and fabricated a high-Q sinusoidal Bragg resonator designed to excite high frequency CARM oscillation of the TE_{31} cylindrical cavity mode at 18.9 GHz. The measured reflectivity of the TE_{31} mode is consistent with the prediction of uncoupled single mode theory. A high quality annular electron beam with low velocity spread and energy spread is produced through an apertured mask-anode. The apertured electron beam has been characterized by the use of glass plate diagnostics. The measured beam velocity ratio, v_{| }/v_{|}, was shown to be in agreement with computer simulation results and the theoretical predictions. Experiments have been performed for 4 cases: (1) Bragg resonator with ripples half-inward, (2) large diameter smooth tube without Bragg resonator, (3) Bragg resonator with ripples fully-outward, and (4) small diameter smooth tube without Bragg resonator. The Bragg resonator with ripples half-inward generated high power microwave radiation from TE_ {11} gyro-BWO interactions, TE _{21} absolute instability, and high harmonic gyrotron modes. Considerably less power from the TE_{11} gyro -BWO was observed for the Bragg resonator with ripples fully -outward. The microwave emission from the TE_ {21} absolute instability in the Bragg resonator with ripples fully-outward was successfully suppressed by lowering the cavity magnetic field. These three undesired oscillations, (TE _{21} absolute instability, TE _{11} gyro-BWO, TE _{51} second and third harmonic), were the most

  4. Towards A Model-Based Prognostics Methodology for Electrolytic Capacitors: A Case Study Based on Electrical Overstress Accelerated Aging

    NASA Technical Reports Server (NTRS)

    Celaya, Jose R.; Kulkarni, Chetan S.; Biswas, Gautam; Goebel, Kai

    2012-01-01

    A remaining useful life prediction methodology for electrolytic capacitors is presented. This methodology is based on the Kalman filter framework and an empirical degradation model. Electrolytic capacitors are used in several applications ranging from power supplies on critical avionics equipment to power drivers for electro-mechanical actuators. These devices are known for their comparatively low reliability and given their criticality in electronics subsystems they are a good candidate for component level prognostics and health management. Prognostics provides a way to assess remaining useful life of a capacitor based on its current state of health and its anticipated future usage and operational conditions. We present here also, experimental results of an accelerated aging test under electrical stresses. The data obtained in this test form the basis for a remaining life prediction algorithm where a model of the degradation process is suggested. This preliminary remaining life prediction algorithm serves as a demonstration of how prognostics methodologies could be used for electrolytic capacitors. In addition, the use degradation progression data from accelerated aging, provides an avenue for validation of applications of the Kalman filter based prognostics methods typically used for remaining useful life predictions in other applications.

  5. Mice deficient in Rbm38, a target of the p53 family, are susceptible to accelerated aging and spontaneous tumors

    PubMed Central

    Zhang, Jin; Xu, Enshun; Ren, Cong; Yan, Wensheng; Zhang, Min; Chen, Mingyi; Cardiff, Robert D.; Imai, Denise M.; Wisner, Erik; Chen, Xinbin

    2014-01-01

    RNA-binding motif protein 38 (Rbm38), also called RNPC1 [RNA-binding region (RNP1, RRM) containing 1], is a target of the p53 family and modulates p53 expression via mRNA translation. To investigate the biological function of Rbm38 in vivo, we generated an Rbm38-null mouse model. We showed that mice deficient in Rbm38 exhibit signs of accelerated aging and are prone to hematopoietic defects and spontaneous tumors. To determine the biological significance of the p53-Rbm38 loop, we showed that Rbm38 deficiency enhances accumulation of p53 induced by ionizing radiation (IR) and sensitizes mice to IR-induced lethality in a p53-dependent manner. Most importantly, Rbm38 deficiency markedly decreases the tumor penetrance in mice heterozygous for p53 via enhanced p53 expression. Interestingly, we found that Rbm38 deficiency shortens the life span of, and promotes lymphomagenesis in, mice deficient in p53. These results provide genetic evidence that Rbm38 is necessary for normal hematopoiesis and for suppressing accelerated aging and tumorigenesis. Thus, the p53-Rbm38 axis might be explored for extending longevity and for tumor suppression. PMID:25512531

  6. Multi-Directional Sprinting and Acceleration Phase in Basketball and Handball Players Aged 14 and 15 Years.

    PubMed

    Popowczak, Marek; Rokita, Andrzej; Struzik, Artur; Cichy, Ireneusz; Dudkowski, Andrzej; Chmura, Paweł

    2016-10-01

    An important role in handball and basketball is played by ability to accelerate and ability to repeat multiple sprints. The aim of the study was to assess level of ability in multi-directional sprinting and running time over the first 5 m of the 30 m sprint in 93 basketball and handball players (46 boys and 47 girls) aged 14 to 15 years. The attempts were also made to find the relationships between the time of a 5-m run to evaluate initial acceleration phase and multi-directional sprinting evaluated using Five-Time Shuttle Run To Gates Test Statistical analysis revealed no important differences in times of 5-m runs and times of multi-directional sprinting between groups with different ages, genders, and sports specialties. Furthermore, no significant correlations were found based on Spearman's rank correlation coefficient between times of 5-m run and multi-directional sprinting in the most of subgroups studied. PMID:27565172

  7. Dating, Sex, and Substance Use as Correlates of Adolescents' Subjective Experience of Age

    ERIC Educational Resources Information Center

    Arbeau, Kelly J.; Galambos, Nancy L.; Jansson, S. Mikael

    2007-01-01

    This study examined in a random community-based sample of 664 12-19-year-olds, the relation of subjective experience of age (SEA) with chronological age, dating experience, sexual activity, and substance use. The results revealed a positive linear relation between SEA and chronological age: individuals who were chronologically older felt…

  8. Accelerated aging studies of UHMWPE. I. Effect of resin, processing, and radiation environment on resistance to mechanical degradation.

    PubMed

    Edidin, A A; Herr, M P; Villarraga, M L; Muth, J; Yau, S S; Kurtz, S M

    2002-08-01

    The resin and processing route have been identified as potential variables influencing the mechanical behavior, and hence the clinical performance, of ultra-high molecular weight polyethylene (UHMWPE) orthopedic components. Researchers have reported that components fabricated from 1900 resin may oxidize to a lesser extent than components fabricated from GUR resin during shelf aging after gamma sterilization in air. Conflicting reports on the oxidation resistance for 1900 raise the question of whether resin or manufacturing method, or an interaction between resin and manufacturing method, influences the mechanical behavior of UHMWPE. We conducted a series of accelerated aging studies (no aging, aging in oxygen or in nitrogen) to systematically examine the influence of resin (GUR or 1900), manufacturing method (bulk compression molding or extrusion), and sterilization method (none, in air, or in nitrogen) on the mechanical behavior of UHMWPE. The small punch testing technique was used to evaluate the mechanical behavior of the materials, and Fourier transform infrared spectroscopy was used to characterize the oxidation in selected samples. Our study showed that the sterilization environment, aging condition, and specimen location (surface or subsurface) significantly affected the mechanical behavior of UHMWPE. Each of the three polyethylenes evaluated seem to degrade according to a similar pathway after artificial aging in oxygen and gamma irradiation in air. The initial ability of the materials to exhibit post-yield strain hardening was significantly compromised by degradation. In general, there were only minor differences in the aging behavior of molded and extruded GUR 1050, whereas the molded 1900 material seemed to degrade slightly faster than either of the 1050 materials.

  9. Model experiment of cosmic ray acceleration due to an incoherent wakefield induced by an intense laser pulse

    SciTech Connect

    Kuramitsu, Y.; Sakawa, Y.; Takeda, K.; Tampo, M.; Takabe, H.; Nakanii, N.; Kondo, K.; Tsuji, K.; Kimura, K.; Fukumochi, S.; Kashihara, M.; Tanimoto, T.; Nakamura, H.; Ishikura, T.; Kodama, R.; Mima, K.; Tanaka, K. A.; Mori, Y.; Miura, E.; Kitagawa, Y.

    2011-01-15

    The first report on a model experiment of cosmic ray acceleration by using intense laser pulses is presented. Large amplitude light waves are considered to be excited in the upstream regions of relativistic astrophysical shocks and the wakefield acceleration of cosmic rays can take place. By substituting an intense laser pulse for the large amplitude light waves, such shock environments were modeled in a laboratory plasma. A plasma tube, which is created by imploding a hollow polystyrene cylinder, was irradiated by an intense laser pulse. Nonthermal electrons were generated by the wakefield acceleration and the energy distribution functions of the electrons have a power-law component with an index of {approx}2. The maximum attainable energy of the electrons in the experiment is discussed by a simple analytic model. In the incoherent wakefield the maximum energy can be much larger than one in the coherent field due to the momentum space diffusion or the energy diffusion of electrons.

  10. Accelerating aging of zirconia femoral head implants: change of surface structure and mechanical properties.

    PubMed

    Chowdhury, S; Vohra, Yogesh K; Lemons, Jack E; Ueno, Masaru; Ikeda, Junji

    2007-05-01

    Recently, alternations of zirconia ceramic femoral heads of total hip prostheses during in vivo conditions have caused concern in the medical disciplines regarding phase transformation of zirconia prosthetic components. In this paper, we have investigated the mechanical and structural properties of different laboratory aged zirconia femoral heads and correlated changes in mechanical properties with the phase compositions of the sample. From laser microscope observation, cross-sectional Scanning electron microscopy imaging, and X-ray diffraction analysis on the surface of the zirconia femoral heads, we found monoclinic to tetragonal phase transformation in zirconia prostheses over time during the aging process in the laboratory. Mechanical properties, mainly hardness (H) and Young's modulus (E) values, were measured by nanoindentation technique on the surface of these implants. The results showed that both H and E values decreased with increased monoclinic phase in zirconia, thus confirming a phase transformation over time during aging.

  11. Influence of artificially accelerated ageing on the adhesive joint of plasma treated polymer materials

    NASA Astrophysics Data System (ADS)

    Lehocký, M.; Lapčik, L.; Dlabaja, R.; Rachünek, L.; Stoch, J.

    2004-03-01

    An influence of simulated ageing on the adhesive joint of plasma treated polyethylene (PE) and polypropylene (PP) was tested. Plasma surface treatment was performed in the rf-plasma reactor operating at 13,56 MHz. The simulated ageing of prepared specimens for following tensile testing was carried out under conditions given by Volkswagen standard P-VW 1200. Temperature of ageing was regularly oscillating between -40°C and 80°C (relative humidity 80%) for required time. The mechanical tensile properties of adhesive joint were measured according to the standard ISO 527. Surface analysis of treated polymer substrates was characterized by XPS measurement. The observation of surface structure and morphology was obtained using SEM. We used convenient cyanoacrylate adhesive Loctite E 406 for PE and PP joints. Tested adhesive joints were prepared in compliance with the standard ISO 4587.

  12. DataPlay: Experiments in the Ludic Age

    ERIC Educational Resources Information Center

    Macklin, Colleen

    2011-01-01

    DataPlay is a research project inspired by the concept of a "ludic age" (Chaplin & Zimmerman, 2008), where the challenges of extracting knowledge from the "data deluge" of the information age (Economist, 2010) are met with game-based approaches to information design. This paper examines Mannahatta: The Game in order to…

  13. Physical properties of three maxillofacial materials as a function of accelerated aging.

    PubMed

    Dootz, E R; Koran, A; Craig, R G

    1994-04-01

    This study compares the tensile strength, elongation, Shore-A hardness, and tear resistance of three silicone maxillofacial materials before and after aging to provide comparative data for evaluation of new or experimental elastomers. The materials evaluated were MDX-4-4210, Factor II (A-2186), and Cosmesil. Tests were conducted 24 hours after specimen preparation and were repeated after aging for 900 hours in a Weather-Ometer device. Five samples were made for each material under all test conditions. After testing, mean values were calculated for all materials under all test conditions and were compared by two-way analysis of variance and Tukey intervals at p < or = 0.05.

  14. Shock experiments and numerical simulations on low energy portable electrically exploding foil accelerators.

    PubMed

    Saxena, A K; Kaushik, T C; Gupta, Satish C

    2010-03-01

    Two low energy (1.6 and 8 kJ) portable electrically exploding foil accelerators are developed for moderately high pressure shock studies at small laboratory scale. Projectile velocities up to 4.0 km/s have been measured on Kapton flyers of thickness 125 microm and diameter 8 mm, using an in-house developed Fabry-Perot velocimeter. An asymmetric tilt of typically few milliradians has been measured in flyers using fiber optic technique. High pressure impact experiments have been carried out on tantalum, and aluminum targets up to pressures of 27 and 18 GPa, respectively. Peak particle velocities at the target-glass interface as measured by Fabry-Perot velocimeter have been found in good agreement with the reported equation of state data. A one-dimensional hydrodynamic code based on realistic models of equation of state and electrical resistivity has been developed to numerically simulate the flyer velocity profiles. The developed numerical scheme is validated against experimental and simulation data reported in literature on such systems. Numerically computed flyer velocity profiles and final flyer velocities have been found in close agreement with the previously reported experimental results with a significant improvement over reported magnetohydrodynamic simulations. Numerical modeling of low energy systems reported here predicts flyer velocity profiles higher than experimental values, indicating possibility of further improvement to achieve higher shock pressures.

  15. Numerical simulations of recent proton acceleration experiments with sub-100 TW laser systems

    NASA Astrophysics Data System (ADS)

    Sinigardi, Stefano

    2016-09-01

    Recent experiments carried out at the Italian National Research Center, National Optics Institute Department in Pisa, are showing interesting results regarding maximum proton energies achievable with sub-100 TW laser systems. While laser systems are being continuously upgraded in laboratories around the world, at the same time a new trend on stabilizing and making ion acceleration results reproducible is growing in importance. Almost all applications require a beam with fixed performance, so that the energy spectrum and the total charge exhibit moderate shot to shot variations. This result is surely far from being achieved, but many paths are being explored in order to reach it. Some of the reasons for this variability come from fluctuations in laser intensity and focusing, due to optics instability. Other variation sources come from small differences in the target structure. The target structure can vary substantially, when it is impacted by the main pulse, due to the prepulse duration and intensity, the shape of the main pulse and the total energy deposited. In order to qualitatively describe the prepulse effect, we will present a two dimensional parametric scan of its relevant parameters. A single case is also analyzed with a full three dimensional simulation, obtaining reasonable agreement between the numerical and the experimental energy spectrum.

  16. Ice Target and Gas Target Experiments in the IMPACT Dust Accelerator

    NASA Astrophysics Data System (ADS)

    Munsat, T. L.; Collette, A.; Dee, R.; Gruen, E.; Horanyi, M.; James, D.; Janches, D.; Kempf, S.; Plane, J. M. C.; Shu, A. J.; Simolka, J.; Sternovsky, Z.; Thomas, E.

    2014-12-01

    The dust accelerator facility at the SSERVI Institute for Modeling Plasma, Atmospheres, and Cosmic Dust (IMPACT) is presently implementing two major target upgrades: a cryogenic ice target and a high-pressure gas target. The ice target consists of a LN2 cryogenic system connected to both a water-ice deposition system as well as a movable freezer/holder for a pre-mixed liquid cartridge. Planned experiments include the bombardment of a variety of frozen targets and simulated ice/regolith mixtures, and the assessment of all impact products (solid ejecta, gas, plasma) as well as spectroscopy of both the impact-produced light flashes and the reflected spectra (UV, visible, IR). Such measurements are highly relevant to both physical and chemical surface modification of airless bodies due to micrometeoroid impacts. The gas target consists of a differentially pumped chamber kept at moderate background pressures, such that high-velocity (~10 km/s) micrometeoroids are completely ablated within 10's of cm (i.e. within the measurement chamber). The chamber is configured with segmented electrodes to perform a spatially-resolved measurement of charge production during ablation, and localized light-collection optics enable an assessment of the light production (luminous efficiency). Such studies are critical to the understanding of past and future ground-based measurements of meteor ablation in Earth's atmosphere, which in turn can potentially provide the best estimates of the interplanetary dust particle flux.

  17. Using precise word timing information improves decoding accuracy in a multiband-accelerated multimodal reading experiment.

    PubMed

    Vu, An T; Phillips, Jeffrey S; Kay, Kendrick; Phillips, Matthew E; Johnson, Matthew R; Shinkareva, Svetlana V; Tubridy, Shannon; Millin, Rachel; Grossman, Murray; Gureckis, Todd; Bhattacharyya, Rajan; Yacoub, Essa

    2016-01-01

    The blood-oxygen-level-dependent (BOLD) signal measured in functional magnetic resonance imaging (fMRI) experiments is generally regarded as sluggish and poorly suited for probing neural function at the rapid timescales involved in sentence comprehension. However, recent studies have shown the value of acquiring data with very short repetition times (TRs), not merely in terms of improvements in contrast to noise ratio (CNR) through averaging, but also in terms of additional fine-grained temporal information. Using multiband-accelerated fMRI, we achieved whole-brain scans at 3-mm resolution with a TR of just 500 ms at both 3T and 7T field strengths. By taking advantage of word timing information, we found that word decoding accuracy across two separate sets of scan sessions improved significantly, with better overall performance at 7T than at 3T. The effect of TR was also investigated; we found that substantial word timing information can be extracted using fast TRs, with diminishing benefits beyond TRs of 1000 ms. PMID:27686111

  18. Using precise word timing information improves decoding accuracy in a multiband-accelerated multimodal reading experiment.

    PubMed

    Vu, An T; Phillips, Jeffrey S; Kay, Kendrick; Phillips, Matthew E; Johnson, Matthew R; Shinkareva, Svetlana V; Tubridy, Shannon; Millin, Rachel; Grossman, Murray; Gureckis, Todd; Bhattacharyya, Rajan; Yacoub, Essa

    2016-01-01

    The blood-oxygen-level-dependent (BOLD) signal measured in functional magnetic resonance imaging (fMRI) experiments is generally regarded as sluggish and poorly suited for probing neural function at the rapid timescales involved in sentence comprehension. However, recent studies have shown the value of acquiring data with very short repetition times (TRs), not merely in terms of improvements in contrast to noise ratio (CNR) through averaging, but also in terms of additional fine-grained temporal information. Using multiband-accelerated fMRI, we achieved whole-brain scans at 3-mm resolution with a TR of just 500 ms at both 3T and 7T field strengths. By taking advantage of word timing information, we found that word decoding accuracy across two separate sets of scan sessions improved significantly, with better overall performance at 7T than at 3T. The effect of TR was also investigated; we found that substantial word timing information can be extracted using fast TRs, with diminishing benefits beyond TRs of 1000 ms.

  19. Accelerating phylogenetics computing on the desktop: experiments with executing UPGMA in programmable logic.

    PubMed

    Davis, J P; Akella, S; Waddell, P H

    2004-01-01

    Having greater computational power on the desktop for processing taxa data sets has been a dream of biologists/statisticians involved in phylogenetics data analysis. Many existing algorithms have been highly optimized-one example being Felsenstein's PHYLIP code, written in C, for UPGMA and neighbor joining algorithms. However, the ability to process more than a few tens of taxa in a reasonable amount of time using conventional computers has not yielded a satisfactory speedup in data processing, making it difficult for phylogenetics practitioners to quickly explore data sets-such as might be done from a laptop computer. We discuss the application of custom computing techniques to phylogenetics. In particular, we apply this technology to speed up UPGMA algorithm execution by a factor of a hundred, against that of PHYLIP code running on the same PC. We report on these experiments and discuss how custom computing techniques can be used to not only accelerate phylogenetics algorithm performance on the desktop, but also on larger, high-performance computing engines, thus enabling the high-speed processing of data sets involving thousands of taxa. PMID:17270875

  20. Shock experiments and numerical simulations on low energy portable electrically exploding foil accelerators

    SciTech Connect

    Saxena, A. K.; Kaushik, T. C.; Gupta, Satish C.

    2010-03-15

    Two low energy (1.6 and 8 kJ) portable electrically exploding foil accelerators are developed for moderately high pressure shock studies at small laboratory scale. Projectile velocities up to 4.0 km/s have been measured on Kapton flyers of thickness 125 {mu}m and diameter 8 mm, using an in-house developed Fabry-Perot velocimeter. An asymmetric tilt of typically few milliradians has been measured in flyers using fiber optic technique. High pressure impact experiments have been carried out on tantalum, and aluminum targets up to pressures of 27 and 18 GPa, respectively. Peak particle velocities at the target-glass interface as measured by Fabry-Perot velocimeter have been found in good agreement with the reported equation of state data. A one-dimensional hydrodynamic code based on realistic models of equation of state and electrical resistivity has been developed to numerically simulate the flyer velocity profiles. The developed numerical scheme is validated against experimental and simulation data reported in literature on such systems. Numerically computed flyer velocity profiles and final flyer velocities have been found in close agreement with the previously reported experimental results with a significant improvement over reported magnetohydrodynamic simulations. Numerical modeling of low energy systems reported here predicts flyer velocity profiles higher than experimental values, indicating possibility of further improvement to achieve higher shock pressures.

  1. Exposure to radiation accelerates normal brain aging and produces deficits in spatial learning and memory

    NASA Astrophysics Data System (ADS)

    Shukitt-Hale, B.; Casadesus, G.; Carey, A.; Rabin, B. M.; Joseph, J. A.

    Previous studies have shown that radiation exposure, particularly to particles of high energy and charge (HZE particles), produces deficits in spatial learning and memory. These adverse behavioral effects are similar to those seen in aged animals. It is possible that these shared effects may be produced by the same mechanism; oxidative stress damage to the central nervous system caused by an increased release of reactive oxygen species is likely responsible for the deficits seen in aging and following irradiation. Both aged and irradiated rats display cognitive impairment in tests of spatial learning and memory such as the Morris water maze and the radial arm maze. These rats have decrements in the ability to build spatial representations of the environment and they utilize non-spatial strategies to solve tasks. Furthermore, they show a lack of spatial preference, due to a decline in the ability to process or retain place (position of a goal with reference to a "map" provided by the configuration of numerous cues in the environment) information. These declines in spatial memory occur in measures dependent on both reference and working memory, and in the flexibility to reset mental images. These results show that irradiation with high-energy particles produces age-like decrements in cognitive behavior that may impair the ability of astronauts to perform critical tasks during long-term space travel beyond the magnetosphere. Supported by NASA Grants NAG9-1190 and NAG9-1529

  2. Semantic Development in Spanish-English Bilingual Children: Effects of Age and Language Experience

    ERIC Educational Resources Information Center

    Sheng, Li; Bedore, Lisa M.; Pena, Elizabeth D.; Fiestas, Christine

    2013-01-01

    This study examines semantic development in 60 Spanish-English bilingual children, ages 7 years 3 months to 9 years 11 months, who differed orthogonally in age (younger, older) and language experience (higher English experience [HEE], higher Spanish experience [HSE]). Children produced 3 associations to 12 pairs of translation equivalents. Older…

  3. The Boeing photocathode accelerator magnetic pulse compression and energy recovery experiment

    SciTech Connect

    Dowell, D.H.; Adamski, J.L.; Hayward, T.D.

    1995-12-31

    An 18 MeV, photocathode accelerator operating at 433 MHz is being commissioned for FEL applications. The accelerator consists of a two-cell RF photocathode imjector followed by four new multicell cavities. The two cell injector has previously been operated at a micropulse repetition frequency of 27 MHz, a micropulse charge of 5 nC and 25% duty factor.

  4. "DIANA" - A New, Deep-Underground Accelerator Facility for Astrophysics Experiments

    SciTech Connect

    Leitner, M.; Leitner, D.; Lemut, A.; Vetter, P.; Wiescher, M.

    2009-05-28

    The DIANA project (Dakota Ion Accelerators for Nuclear Astrophysics) is a collaboration between the University of Notre Dame, University of North Carolina, Western Michigan University, and Lawrence Berkeley National Laboratory to build a nuclear astrophysics accelerator facility 1.4 km below ground. DIANA is part of the US proposal DUSEL (Deep Underground Science and Engineering Laboratory) to establish a cross-disciplinary underground laboratory in the former gold mine of Homestake in South Dakota, USA. DIANA would consist of two high-current accelerators, a 30 to 400 kV variable, high-voltage platform, and a second, dynamitron accelerator with a voltage range of 350 kV to 3 MV. As a unique feature, both accelerators are planned to be equipped with either high-current microwave ion sources or multi-charged ECR ion sources producing ions from protons to oxygen. Electrostatic quadrupole transport elements will be incorporated in the dynamitron high voltage column. Compared to current astrophysics facilities, DIANA could increase the available beam densities on target by magnitudes: up to 100 mA on the low energy accelerator and several mA on the high energy accelerator. An integral part of the DIANA project is the development of a high-density super-sonic gas-jet target which can handle these anticipated beam powers. The paper will explain the main components of the DIANA accelerators and their beam transport lines and will discuss related technical challenges.

  5. An auditory event related potential evaluation of sonar task experience and age.

    PubMed

    Merrill, L L; Kobus, D A; McGuigan, F J

    1995-06-01

    To gauge the interaction of real-world sonar-task experience and age on brain electrical activity, the effect of sonar experience and age on event related potentials (ERP) was examined. A three-group design was used and the results suggest that sonar experience and age affect the amplitude and distribution of the ERP component. The results concerning age and ERPs support and extend the results of previous studies and suggest that age-related differences occur at a much younger age than is reported elsewhere. Attentional and stimulus evaluation processes which have been linked to parameters of the ERP component may be enhanced with real-world auditory task experience. Research on ERP should control for the possible confounds of auditory-task experience and age.

  6. Age-related trends in gene expression in the chemosensory-nasal mucosae of senescence-accelerated mice.

    PubMed

    Getchell, Thomas V; Peng, Xuejun; Stromberg, Arnold J; Chen, Kuey-Chu; Paul Green, C; Subhedar, Nishikant K; Shah, Dharmen S; Mattson, Mark P; Getchell, Marilyn L

    2003-04-01

    We have utilized high-density GeneChip oligonucleotide arrays to investigate the use of the senescence-accelerated mouse (SAM) as a biogerontological resource to identify patterns of gene expression in the chemosensory-nasal mucosa. Gene profiling in chronologically young and old mice of the senescence-resistant (SAMR) and senescence-prone (SAMP) strains revealed 133 known genes that were modulated by a three-fold or greater change either in one strain or the other or in both strains during aging. We also identified known genes in our study which based on their encoded proteins were identified as aging-related genes in the aging neocortex and cerebellum of mice as reported by Lee et al. (2000) [Nat. Genet. 25 (2000) 294]. Changes in gene profiles for chemosensory-related genes including olfactory and vomeronasal receptors, sensory transduction-associated proteins, and odor and pheromone transport molecules in the young SAMR and SAMP were compared with age-matched C57BL/6J mice. An analysis of known gene expression profiles suggests that changes in the expression of immune factor genes and genes associated with cell cycle progression and cell death were particularly prominent in the old SAM strains. A preliminary cellular validation study supported the dysregulation of cell cycle-related genes in the old SAM strains. The results of our initial study indicated that the use of the SAM models of aging could provide substantive information leading to a more fundamental understanding of the aging process in the chemosensory-nasal mucosa at the genomic, molecular, and cellular levels. PMID:12605961

  7. Target disruption of ribosomal protein pNO40 accelerates aging and impairs osteogenic differentiation of mesenchymal stem cells.

    PubMed

    Lin, Yen-Ming; Wu, Chih-Ching; Chang, Yu-Chen; Wu, Chu-Han; Ho, Hsien Li; Hu, Ji Wei; Chang, Ren-Chi; Wang, Chung-Ta; Ouyang, Pin

    2016-01-22

    pNO40/PS1D, a novel nucleolar protein, has been characterized as a core protein of eukaryotic 60S ribosome and at least two splicing forms of pNO40 mRNAs with alternative starting sites have been identified. Through production of knockout (ko) mice with either exon 2 (△E2), exon 4 (△E4) or △E2+E4 targeted disruption we identified a cryptic splicing product occurring in the ko tissues examined which in general cannot be observed in regular RT-PCR detection of wild-type (wt) animals. Among ko animals, △E4 null embryos exhibited prominent senescence-associated β-galactosidase (SA-β-gal) staining, a marker for senescent cells, in notochord, forelimbs and heart while bone marrow-derived mesenchymal stem cells (MSCs) from △E4 null mice developed accelerated aging and osteogenic differentiation defects compared to those from wt and other isoform mutant mice. Examination of the causal relationship between pNO40 deficiency and MSC-accelerated aging revealed △E4 null disruption in MSCs elicits high levels of ROS and elevated expression levels of p16 and Rb but not p53. Further analysis with iTraq identified CYP1B1, a component of the cytochrome p450 system, as a potential molecule mediating ROS generation in pNO40 deficient MSCs. We herein established a mouse model of MSC aging through pNO40-targeted depletion and demonstrated the effects of loss of pNO40 on bone homeostasis.

  8. Inflammatory insult during pregnancy accelerates age-related behavioral and neurobiochemical changes in CD-1 mice.

    PubMed

    Li, Xue-Yan; Wang, Fang; Chen, Gui-Hai; Li, Xue-Wei; Yang, Qi-Gang; Cao, Lei; Yan, Wen-Wen

    2016-06-01

    Data shows that inflammation during pregnancy significantly exerts a long-term influence on offspring, such as increasing the risk of adult cognition decline in animals. However, it is unclear whether gestational inflammation affects the neurobehavioral and neurobiochemical outcomes in the mother-self during aging. In this study, pregnant CD-1 mice intraperitoneally received lipopolysaccharide (LPS) in two doses (25 and 50 g/kg, respectively) or normal saline daily during gestational days 15-17. At the age of 15 months, a battery of behavioral tasks was employed to evaluate their species-typical behaviors, sensorimotor ability, anxiety levels, and spatial learning and memory abilities. An immunohistochemical method was utilized preliminarily to detect neurobiochemical indicators consisting of amyloid-β, phosphorylated tau, presynaptic proteins synaptotagmin-1 and syntaxin-1, glial fibrillary acidic protein (GFAP), and histone-4 acetylation on the K8 site (H4K8ac). The behavioral results showed that LPS exposure during pregnancy exacerbated a decline in 15-month-old CD-1 mice's abilities to nest, their sensorimotor and spatial learning and memory capabilities, and increased their anxiety levels. The neurobiochemical results indicated that gestational LPS exposure also intensified age-related hippocampal changes, including increased amyloid-β42, phosphorylated tau, synaptotagmin-1 and GFAP, and decreased syntaxin-1 and H4K8ac. Our results suggested that the inflammatory insult during pregnancy could be an important risk factor for the development of Alzheimer's disease, and the H4K8 acetylation might play an important role in the underlying mechanism. This study offers a perspective for improving strategies that support healthy development and successful aging.

  9. Energy excess is the main cause of accelerated aging of mammals

    PubMed Central

    Biliński, Tomasz; Paszkiewicz, Tadeusz; Zadrag-Tecza, Renata

    2015-01-01

    The analysis of cases of unusually high longevity of naked mole rats and an alternative explanation of the phenomenon of calorie restriction effects in monkeys allowed for postulating that any factor preventing an excess of energy consumed, leads to increased lifespan, both in evolutionary and an individual lifetime scale. It is postulated that in mammals the most destructive processes resulting in shortening of life are not restricted to the phenomena explained by the hyperfunction theory of Mikhail Blagosklonny. Hyperfunction, understood as unnecessary or even adverse syntheses of cell components, can be to some extent prevented by lowered intake of nutrients when body growth ceases. We postulate also the contribution of glyco/lipotoxicity to aging, resulting from the excess of energy. Besides two other factors seem to participate in aging. One of them is lack of telomerase activity in some somatic cells. The second factor concerns epigenetic phenomena. Excessive activity of epigenetic maintenance system probably turns off some crucial organismal functions. Another epigenetic factor playing important role could be the micro RNA system deciding on expression of numerous age-related diseases. However, low extrinsic mortality from predation is a conditio sine qua non of the expression of all longevity phenotypes in animals. Among all long-lived animals, naked mole rats are unique in the elimination of neoplasia, which is accompanied by delayed functional symptoms of senescence. The question whether simultaneous disappearance of neoplasia and delayed senescence is accidental or not remains open. PMID:26079722

  10. Use of organic solderability preservatives on solderability retention of copper after accelerated aging

    SciTech Connect

    Hernandez, C.L.; Sorensen, N.R.; Lucero, S.J.

    1997-02-01

    Organic solderability preservatives (OSP`s) have been used by the electronics industry for some time to maintain the solderability of circuit boards and components. Since solderability affects both manufacturing efficiency and product reliability, there is significant interest in maintaining good solder wettability. There is often a considerable time interval between the initial fabrication of a circuit board or component and its use at the assembly level. Parts are often stored under a variety of conditions, in many cases not well controlled. Solder wettability can deteriorate during storage, especially in harsh environments. This paper describes the ongoing efforts at Sandia National Laboratories to quantify solder watability on bare and aged copper surfaces. Benzotriazole and imidazole were applied to electronic grade copper to retard aging effects on solderability. The coupons were introduced into Sandia`s Facility for Atmospheric Corrosion Testing (FACT) to simulate aging in a typical indoor industrial environment. H{sub 2}S, NO{sub 2} and Cl{sub 2} mixed gas was introduced into the test cell and maintained at 35{degrees}C and 70% relative humidity for test periods of one day to two weeks. The OSP`s generally performed better than bare Cu, although solderability diminished with increasing exposure times.

  11. An assessment of anti-Müllerian hormone in predicting mating outcomes in female hamsters that have undergone natural and chemically-accelerated reproductive aging.

    PubMed

    Roosa, Kristen A; Zysling, Devin A; Place, Ned J

    2015-04-01

    In mammals, female fertility declines with age due in part to a progressive loss of ovarian follicles. The rate of follicle decline varies among individuals making it difficult to predict the age of onset of reproductive senescence. Serum anti-Müllerian hormone (AMH) concentrations correlate with the numbers of ovarian follicles, and therefore, AMH could be a useful predictor of female fertility. In women and some production animals, AMH is used to identify which individuals will respond best to ovarian stimulation for assisted reproductive technologies. However, few studies have evaluated AMH's predictive value in unassisted reproduction, and they have yielded conflicting results. To assess the predictive value of AMH in the context of reproductive aging, we prospectively measured serum AMH in 9-month-old Siberian hamsters shortly before breeding them. Female Siberian hamsters experience substantial declines in fertility and fecundity by 9months of age. We also measured serum AMH in 5-month-old females treated with 4-vinylcyclohexene diepoxide (VCD), which selectively destroys ovarian follicles and functionally accelerates ovarian aging. Vehicle-treated 5-month-old females served as controls. AMH concentrations were significantly reduced in VCD-treated females yet many females with low AMH reproduced successfully. On average, both young and old hamsters that littered had higher AMH concentrations than females that did not. However, some females with relatively high AMH concentrations failed to litter, whereas several with low AMH succeeded. Our results suggest that mean AMH concentration can predict mating outcomes on a population or group level, but on an individual basis, a single AMH determination is less informative.

  12. Parkinson's disease accelerates age-related decline in haptic perception by altering somatosensory integration.

    PubMed

    Konczak, Jürgen; Sciutti, Alessandra; Avanzino, Laura; Squeri, Valentina; Gori, Monica; Masia, Lorenzo; Abbruzzese, Giovanni; Sandini, Giulio

    2012-11-01

    This study investigated how Parkinson's disease alters haptic perception and the underlying mechanisms of somatosensory and sensorimotor integration. Changes in haptic sensitivity and acuity (the abilities to detect and to discriminate between haptic stimuli) due to Parkinson's disease were systematically quantified and contrasted to the performance of healthy older and young adults. Using a robotic force environment, virtual contours of various curvatures were presented. Participants explored these contours with their hands and indicated verbally whether they could detect or discriminate between two contours. To understand what aspects of sensory or sensorimotor integration are altered by ageing and disease, we manipulated the sensorimotor aspect of the task: the robot either guided the hand along the contour or the participant actively moved the hand. Active exploration relies on multimodal sensory and sensorimotor integration, while passive guidance only requires sensory integration of proprioceptive and tactile information. The main findings of the study are as follows: first, a decline in haptic precision can already be observed in adults before the age of 70 years. Parkinson's disease may lead to an additional decrease in haptic sensitivity well beyond the levels typically seen in middle-aged and older adults. Second, the haptic deficit in Parkinson's disease is general in nature. It becomes manifest as a decrease in sensitivity and acuity (i.e. a smaller perceivable range and a diminished ability to discriminate between two perceivable haptic stimuli). Third, thresholds during both active and passive exploration are elevated, but not significantly different from each other. That is, active exploration did not enhance the haptic deficit when compared to passive hand motion. This implies that Parkinson's disease affects early stages of somatosensory integration that ultimately have an impact on processes of sensorimotor integration. Our results suggest that

  13. Deterioration of the Medial Olivocochlear Efferent System Accelerates Age-Related Hearing Loss in Pax2-Isl1 Transgenic Mice.

    PubMed

    Chumak, Tetyana; Bohuslavova, Romana; Macova, Iva; Dodd, Nicole; Buckiova, Daniela; Fritzsch, Bernd; Syka, Josef; Pavlinkova, Gabriela

    2016-05-01

    The development, maturation, and maintenance of the inner ear are governed by temporal and spatial expression cascades of transcription factors that form a gene regulatory network. ISLET1 (ISL1) may be one of the major players in this cascade, and in order to study its role in the regulation of inner ear development, we produced a transgenic mouse overexpressing Isl1 under the Pax2 promoter. Pax2-regulated ISL1 overexpression increases the embryonic ISL1(+) domain and induces accelerated nerve fiber extension and branching in E12.5 embryos. Despite these gains in early development, the overexpression of ISL1 impairs the maintenance and function of hair cells of the organ of Corti. Mutant mice exhibit hyperactivity, circling behavior, and progressive age-related decline in hearing functions, which is reflected in reduced otoacoustic emissions (DPOAEs) followed by elevated hearing thresholds. The reduction of the amplitude of DPOAEs in transgenic mice was first detected at 1 month of age. By 6-9 months of age, DPOAEs completely disappeared, suggesting a functional inefficiency of outer hair cells (OHCs). The timing of DPOAE reduction coincides with the onset of the deterioration of cochlear efferent terminals. In contrast to these effects on efferents, we only found a moderate loss of OHCs and spiral ganglion neurons. For the first time, our results show that the genetic alteration of the medial olivocochlear (MOC) efferent system induces an early onset of age-related hearing loss. Thus, the neurodegeneration of the MOC system could be a contributing factor to the pathology of age-related hearing loss.

  14. Mevastatin accelerates loss of synaptic proteins and neurite degeneration in aging cortical neurons in a heme-independent manner.

    PubMed

    Kannan, Madhuvanthi; Steinert, Joern R; Forsythe, Ian D; Smith, Andrew G; Chernova, Tatyana

    2010-09-01

    The therapeutic use of statins in reducing cholesterol requires careful assessment of potential neuroprotective and/or neurotoxic mechanisms. Chronic treatment with mevastatin (MV) exerts effects on cortical neuron morphology, protein expression and synaptic function in primary culture. MV impaired expression of synaptic proteins, reduced N-methyl-d-aspartate receptor (NMDAR) currents and accelerated neurodegeneration associated with aging. The down-regulating effect of MV on neuronal protein expression was additive with aging-associated decline in culture. Induction of Heme oxygenase-1 (HMOX1) by MV was superimposed on age-related up-regulation. Comparison of MV-treated and heme-deficient neurons showed that inhibition of heme synthesis (by succinyl acetone) had similar damaging effect on neurite integrity and MNDAR expression and function but not on expression of the receptor for neuropeptide Y1 (NPY1R). Replacement of heme in heme-deficient cultures restored protein expression but had no effect in those cultures co-treated with MV. Despite the dramatic induction of HMOX1, intracellular heme remained sufficient in MV-treated cultures, consistent with a heme-independent mechanism of MV-induced neurotoxicity and this was confirmed by analysing neurons with lentiviral over-expression of HMOX1. We conclude that MV exerts a neurotoxic effect in cultured neurons in a heme-independent manner.

  15. Accelerated age-related olfactory decline among type 1 Usher patients

    PubMed Central

    Ribeiro, João Carlos; Oliveiros, Bárbara; Pereira, Paulo; António, Natália; Hummel, Thomas; Paiva, António; Silva, Eduardo D.

    2016-01-01

    Usher Syndrome (USH) is a rare disease with hearing loss, retinitis pigmentosa and, sometimes, vestibular dysfunction. A phenotype heterogeneity is reported. Recent evidence indicates that USH is likely to belong to an emerging class of sensory ciliopathies. Olfaction has recently been implicated in ciliopathies, but the scarce literature about olfaction in USH show conflicting results. We aim to evaluate olfactory impairment as a possible clinical manifestation of USH. Prospective clinical study that included 65 patients with USH and 65 normal age-gender-smoking-habits pair matched subjects. A cross culturally validated version of the Sniffin’ Sticks olfaction test was used. Young patients with USH have significantly better olfactory scores than healthy controls. We observe that USH type 1 have a faster ageing olfactory decrease than what happens in healthy subjects, leading to significantly lower olfactory scores in older USH1 patients. Moreover, USH type 1 patients showed significantly higher olfactory scores than USH type 2, what can help distinguishing them. Olfaction represents an attractive tool for USH type classification and pre diagnostic screening due to the low cost and non-invasive nature of the testing. Olfactory dysfunction should be considered among the spectrum of clinical manifestations of Usher syndrome. PMID:27329700

  16. Planned High-gradient Flat-beam-driven Dielectric Wakefield Experiments at the Fermilab’s Advanced Superconducting Test Accelerator

    SciTech Connect

    Lemery, Francois; Mihalcea, Daniel; Piot, Philippe; Zhu, Jun

    2014-07-01

    In beam driven dielectric wakefield acceleration (DWA), high-gradient short-wavelength accelerating fields are generally achieved by employing dielectric-lined waveguides (DLWs)  with small aperture which constraints the beam sizes. In this paper we investigate the possibility of using a low-energy (50-MeV) flat beams to induce high-gradient wakes in a slab-symmetric DLW. We demonstrate via numerical simulations the possibility to produce axial electric field with peak amplitude close to 0.5 GV/m. Our studies are carried out using the Fermilab's Advanced Superconducting Test Accelerator (ASTA) photoinjector beamline. We finally discuss a possible experiment that could be performed in the ASTA photoinjector and eventually at higher energies.  

  17. Experiences with physical conditioning programs in middle-aged men

    NASA Technical Reports Server (NTRS)

    Schuster, B.; Stanley, E.

    1969-01-01

    Long term effects of physical exercise and conditioning in the prevention and treatment of coronary heart disease are studied. Some aspects of the problem are outlined and difficulties encountered in a group of middle aged business executives using a carefully prescribed, but non-regimented and loosely supervised conditioning program employing commonly used forms of exercise (bicycling and jogging), are described.

  18. The Experience of Age-Related Macular Degeneration

    ERIC Educational Resources Information Center

    Wong, Elaine Y. H.; Guymer, Robyn H.; Hassell, Jennifer B.; Keeffe, Jill E.

    2004-01-01

    This qualitative article describes the impact of age-related macular degeneration (ARMD) among 15 participants: how a person makes sense of ARMD, the effect of ARMD on the person's quality of life, the psychological disturbances associated with the limitations of ARMD, and the influence of ARMD on social interactions. Such in-depth appreciation of…

  19. Learning Wellness: How Ageing Australians Experience Health Information Literacy

    ERIC Educational Resources Information Center

    Yates, Christine; Partridge, Helen; Bruce, Christine

    2009-01-01

    Given identified synergies between information use and health status greater understanding is needed about how people use information to learn about their health. This paper presents the findings of preliminary research into health information literacy. Analysis of data from semi-structured interviews revealed six different ways ageing Australians…

  20. Optimization of magnetically accelerated, ultra-high velocity aluminum flyer plates for use in plate impact, shock wave experiments.

    SciTech Connect

    Cochrane, Kyle Robert; Knudson, Marcus D.; Slutz, Stephen A.; Lemke, Raymond William; Davis, J. P.; Harjes, Henry Charles III; Giunta, Anthony Andrew; Bliss, David Emery

    2005-05-01

    The intense magnetic field produced by the 20 MA Z accelerator is used as an impulsive pressure source to accelerate metal flyer plates to high velocity for the purpose of performing plate impact, shock wave experiments. This capability has been significantly enhanced by the recently developed pulse shaping capability of Z, which enables tailoring the rise time to peak current for a specific material and drive pressure to avoid shock formation within the flyer plate during acceleration. Consequently, full advantage can be taken of the available current to achieve the maximum possible magnetic drive pressure. In this way, peak magnetic drive pressures up to 490 GPa have been produced, which shocklessly accelerated 850 {micro}m aluminum (6061-T6) flyer plates to peak velocities of 34 km/s. We discuss magnetohydrodynamic (MHD) simulations that are used to optimize the magnetic pressure for a given flyer load and to determine the shape of the current rise time that precludes shock formation within the flyer during acceleration to peak velocity. In addition, we present results pertaining to plate impact, shock wave experiments in which the aluminum flyer plates were magnetically accelerated across a vacuum gap and impacted z-cut, {alpha}-quartz targets. Accurate measurements of resulting quartz shock velocities are presented and analyzed through high-fidelity MHD simulations enhanced using optimization techniques. Results show that a fraction of the flyer remains at solid density at impact, that the fraction of material at solid density decreases with increasing magnetic pressure, and that the observed abrupt decrease in the quartz shock velocity is well correlated with the melt transition in the aluminum flyer.

  1. Neutrino factory and beta beam: accelerator options for future neutrino experiments

    SciTech Connect

    Zisman, Michael S.

    2012-06-03

    Two accelerator options for producing intense neutrino beams a Neutrino Factory based on stored muon beams and a Beta Beam facility based on stored beams of beta unstable ions are described. Technical challenges for each are described and current R&D efforts aimed at mitigating these challenges are indicated. Progress is being made in the design of both types of facility, each of which would extend the state-of-the-art in accelerator science.

  2. Radiolysis as a solution for accelerated ageing studies of electrolytes in Lithium-ion batteries.

    PubMed

    Ortiz, Daniel; Steinmetz, Vincent; Durand, Delphine; Legand, Solène; Dauvois, Vincent; Maître, Philippe; Le Caër, Sophie

    2015-01-01

    Diethyl carbonate and dimethyl carbonate are prototype examples of eco-friendly solvents used in lithium-ion batteries. Nevertheless, their degradation products affect both the battery performance and its safety. Therefore, it is of paramount importance to understand the reaction mechanisms involved in the ageing processes. Among those, redox processes are likely to play a critical role. Here we show that radiolysis is an ideal tool to generate the electrolytes degradation products. The major gases detected after irradiation (H2, CH4, C2H6, CO and CO2) are identified and quantified. Moreover, the chemical compounds formed in the liquid phase are characterized by different mass spectrometry techniques. Reaction mechanisms are then proposed. The detected products are consistent with those of the cycling of Li-based cells. This demonstrates that radiolysis is a versatile and very helpful tool to better understand the phenomena occurring in lithium-ion batteries. PMID:25907411

  3. Radiolysis as a solution for accelerated ageing studies of electrolytes in Lithium-ion batteries

    NASA Astrophysics Data System (ADS)

    Ortiz, Daniel; Steinmetz, Vincent; Durand, Delphine; Legand, Solène; Dauvois, Vincent; Maître, Philippe; Le Caër, Sophie

    2015-04-01

    Diethyl carbonate and dimethyl carbonate are prototype examples of eco-friendly solvents used in lithium-ion batteries. Nevertheless, their degradation products affect both the battery performance and its safety. Therefore, it is of paramount importance to understand the reaction mechanisms involved in the ageing processes. Among those, redox processes are likely to play a critical role. Here we show that radiolysis is an ideal tool to generate the electrolytes degradation products. The major gases detected after irradiation (H2, CH4, C2H6, CO and CO2) are identified and quantified. Moreover, the chemical compounds formed in the liquid phase are characterized by different mass spectrometry techniques. Reaction mechanisms are then proposed. The detected products are consistent with those of the cycling of Li-based cells. This demonstrates that radiolysis is a versatile and very helpful tool to better understand the phenomena occurring in lithium-ion batteries.

  4. Radiolysis as a solution for accelerated ageing studies of electrolytes in Lithium-ion batteries

    PubMed Central

    Ortiz, Daniel; Steinmetz, Vincent; Durand, Delphine; Legand, Solène; Dauvois, Vincent; Maître, Philippe; Le Caër, Sophie

    2015-01-01

    Diethyl carbonate and dimethyl carbonate are prototype examples of eco-friendly solvents used in lithium-ion batteries. Nevertheless, their degradation products affect both the battery performance and its safety. Therefore, it is of paramount importance to understand the reaction mechanisms involved in the ageing processes. Among those, redox processes are likely to play a critical role. Here we show that radiolysis is an ideal tool to generate the electrolytes degradation products. The major gases detected after irradiation (H2, CH4, C2H6, CO and CO2) are identified and quantified. Moreover, the chemical compounds formed in the liquid phase are characterized by different mass spectrometry techniques. Reaction mechanisms are then proposed. The detected products are consistent with those of the cycling of Li-based cells. This demonstrates that radiolysis is a versatile and very helpful tool to better understand the phenomena occurring in lithium-ion batteries. PMID:25907411

  5. Supernova/Acceleration Probe: A Satellite Experiment to Study the Nature of the Dark Energy

    SciTech Connect

    Aldering, G.; Althouse, W.; Amanullah, R.; Annis, J.; Astier, P.; Baltay, C.; Barrelet, E.; Basa, E.; Bebek, C.; Bergstrom, L.; Bernstein, G.; Bester, M.; Bigelow, C.; Blandford, R.; Bohlin, R.; Bonissent, A.; Bower, C.; Brown, M.; Campbell, M.; Carithers, W.; Commins, E.; Craig, W.; Day, C.; DeJongh, F.; Deustua, S.; Diehl, T.; Dodelson, S.; Ealet, A.; Ellis, R.; Emmet, W.; Fouchez, D.; Frieman, J.; Fruchter, A.; Gerdes, D.; Gladney, L.; Goldhaber, G.; Goobar, A.; Groom, D.; Heetderks, H.; Hoff, M.; Holland, S.; Huffer, M.; Hui, L.; Huterer, D.; Jain, B.; Jelinsky, P.; Karcher, A.; Kent, S.; Kahn, S.; Kim, A.; Kolbe, W.; Krieger, B.; Kushner, G.; Kuznetsova, N.; Lafever, R.; Lamoureux, J.; Lampton, M.; Le Fevre, O.; Levi, M.; Limon, P.; Lin, H.; Linder, E.; Loken, S.; Lorenzon, W.; Malina, R.; Marriner, J.; Marshall, P.; Massey, R.; Mazure, A.; McKay, T.; McKee, S.; Miquel, R.; Morgan, N.; Mortsell, E.; Mostek, N.; Mufson, S.; Musser, J.; Nugent, P.; Oluseyi, H.; Pain, R.; Palaio, N.; Pankow, D.; Peoples, J.; Perlmutter, S.; Prieto, E.; Rabinowitz, D.; Refregier, A.; Rhodes, J.; Roe, N.; Rusin, D.; Scarpine, V.; Schubnell, M.; Sholl, M.; Samdja, G.; Smith, R.M.; Smoot, G.; Snyder, J.; Spadafora, A.; Stebbine, A.; Stoughton, C.; Szymkowiak, A.; Tarle, G.; Taylor, K.; Tilquin, A.; Tomasch, A.; Tucker, D.; Vincent, D.; von der Lippe, H.; Walder, J-P.; Wang, G.; Wester, W.

    2004-05-12

    The Supernova/Acceleration Probe (SNAP) is a proposed space-based experiment designed to study the dark energy and alternative explanations of the acceleration of the Universes expansion by performing a series of complementary systematics-controlled astrophysical measurements. We here describe a self-consistent reference mission design that can accomplish this goal with the two leading measurement approaches being the Type Ia supernova Hubble diagram and a wide-area weak gravitational lensing survey. This design has been optimized to first order and is now under study for further modification and optimization. A 2-m three-mirror anastigmat wide-field telescope feeds a focal plane consisting of a 0.7 square-degree imager tiled with equal areas of optical CCDs and near infrared sensors, and a high efficiency low-resolution integral field spectrograph. The instrumentation suite provides simultaneous discovery and light-curve measurements of supernovae and then can target individual objects for detailed spectral characterization. The SNAP mission will discover thousands of Type Ia supernovae out to z = 3 and will obtain high-signal-to-noise calibrated light-curves and spectra for a subset of > 2000 supernovae at redshifts between z = 0.1 and 1.7 in a northern field and in a southern field. A wide-field survey covering one thousand square degrees in both northern and southern fields resolves {approx} 100 galaxies per square arcminute, or a total of more than 300 million galaxies. With the PSF stability afforded by a space observatory, SNAP will provide precise and accurate measurements of gravitational lensing. The high-quality data available in space, combined with the large sample of supernovae, will enable stringent control of systematic uncertainties. The resulting data set will be used to determine the energy density of dark energy and parameters that describe its dynamical behavior. The data also provide a direct test of theoretical models for the dark energy

  6. Supernova / Acceleration Probe: a Satellite Experiment to Study the Nature of the Dark Energy

    SciTech Connect

    Aldering, G.; Althouse, W.; Amanullah, R.; Annis, J.; Astier, P.; Baltay, C.; Barrelet, E.; Basa, S.; Bebek, C.; Bergstrom, L.; Bernstein, G.; Bester, M.; Bigelow, B.; Blandford, R.; Bohlin, R.; Bonissent, A.; Bower, C.; Brown, M.; Campbell, M.; Carithers, W.; Commins, E.; /LBL, Berkeley /SLAC /Stockholm U. /Fermilab /Paris U., VI-VII /Yale U. /Pennsylvania U. /UC, Berkeley /Michigan U. /Baltimore, Space Telescope Sci. /Marseille, CPPM /Indiana U. /American Astron. Society /Caltech /Case Western Reserve U. /Cambridge U. /Saclay /Lyon, IPN

    2005-08-15

    The Supernova/Acceleration Probe (SNAP) is a proposed space-based experiment designed to study the dark energy and alternative explanations of the acceleration of the Universe's expansion by performing a series of complementary systematics-controlled astrophysical measurements. We here describe a self-consistent reference mission design that can accomplish this goal with the two leading measurement approaches being the Type Ia supernova Hubble diagram and a wide-area weak gravitational lensing survey. This design has been optimized to first order and is now under study for further modification and optimization. A 2-m three-mirror anastigmat wide-field telescope feeds a focal plane consisting of a 0.7 square-degree imager tiled with equal areas of optical CCDs and near infrared sensors, and a high-efficiency low-resolution integral field spectrograph. The instrumentation suite provides simultaneous discovery and light-curve measurements of supernovae and then can target individual objects for detailed spectral characterization. The SNAP mission will discover thousands of Type Ia supernovae out to z = 3 and will obtain high-signal-to-noise calibrated light-curves and spectra for a subset of > 2000 supernovae at redshifts between z = 0.1 and 1.7 in a northern field and in a southern field. A wide-field survey covering one thousand square degrees in both northern and southern fields resolves {approx} 100 galaxies per square arcminute, or a total of more than 300 million galaxies. With the PSF stability afforded by a space observatory, SNAP will provide precise and accurate measurements of gravitational lensing. The high-quality data available in space, combined with the large sample of supernovae, will enable stringent control of systematic uncertainties. The resulting data set will be used to determine the energy density of dark energy and parameters that describe its dynamical behavior. The data also provide a direct test of theoretical models for the dark energy

  7. Color and opacity of composites protected with surface sealants and submitted to artificial accelerated aging

    PubMed Central

    Aguilar, Fabiano Gamero; Roberti Garcia, Lucas da Fonseca; Cruvinel, Diogo Rodrigues; Sousa, Ana Beatriz Silva; de Carvalho Panzeri Pires-de-Souza, Fernanda

    2012-01-01

    Objectives: To evaluate the color similarity, stability and opacity of composites (TPH, Charisma, and Concept, shade A2) protected with surface sealants (Fortify Plus and Biscover) and cyanoacrylate (Super Bonder). Methods: Forty specimens of each composite were made and separated into 4 groups (n=10) according to the surface protection: GI - without sealant; GII - cyanoacrylate; GIII - Fortify Plus; GIV - Biscover. Color and opacity readings were taken before and after Artificial Acelerated Aging (AAA) and the values obtained for color stability were submitted to statistical analysis by 2-way ANOVA and Bonferroni’s test (P<.05). The values acquired for color similarity were submitted to 1-way ANOVA and Tukey’s test (P<.05). The specimen sufaces were compared before and after AAA using Scanning Electronic Microscopy (SEM). Results: Studied composites did not present the same values for the coordinates L*, a* and b * before AAA, indicating that there was no color similarity among them. All composites presented color alteration after AAA with clinically unacceptable values. Protected groups presented lower opacity variation after AAA, in comparison with the control goup. SEM evaluation demonstrated that AAA increased the surface irregularities in all of the studied groups. Conclusion: Surface sealants were not effective in maintaining composite color, but were able to maintain opacity. PMID:22229004

  8. Mitochondrial superoxide dismutase deficiency accelerates chronological aging in the fission yeast Schizosaccharomyces pombe.

    PubMed

    Ogata, Toshiya; Senoo, Takanori; Kawano, Shinji; Ikeda, Shogo

    2016-01-01

    A mitochondrial superoxide dismutase (SOD2) is the first line of antioxidant defense against mitochondrial superoxide. Even though the involvement of SOD2 in lifespan has been studied extensively in several organisms, characterization of the aging process has not been performed for the sod2 mutant (sod2Δ) of a prominent model Schizosaccharomyces pombe. In this study, we measured the chronological lifespan of sod2Δ cells by their ability to survive in long-term culture. SOD2 deficiency drastically decreased cell viability in the stationary phase. The mutation frequency of nuclear DNA in sod2Δ was elevated in the stationary phase, and cellular proteins and nuclear DNA were extensively degraded, concurrent with cell death. The sod2 gene in wild-type cells could be induced by an increase in endogenous oxidative stresses, after which, SOD2 activity was substantially elevated during the stationary phase. Culture in a lower glucose concentration (calorie restriction) prominently extended the sod2Δ lifespan. Therefore, S. pombe SOD2 plays a critical role in longevity through its upregulation in the non-dividing phase.

  9. Linseed oil presents different patterns of oxidation in real-time and accelerated aging assays.

    PubMed

    Douny, Caroline; Razanakolona, Rina; Ribonnet, Laurence; Milet, Jérôme; Baeten, Vincent; Rogez, Hervé; Scippo, Marie-Louise; Larondelle, Yvan

    2016-10-01

    This study aimed at verifying if the hypothesis that one day at 60°C is equivalent to one month at 20°C could be confirmed during linseed oil aging for 6months at 20°C and 6days at 60°C using the "Schaal oven stability test". Tests were conducted with linseed oil supplemented or not with myricetin or butyl-hydroxytoluene as antioxidants. Oxidation was evaluated with the peroxide and p-anisidine values, as well as the content in conjugated dienes and aldehydes. All four indicators of oxidation showed very different kinetic behaviors at 20 and 60°C. The hypothesis is thus not verified for linseed oil, supplemented or not with antioxidant. In the control oil, the conjugated dienes and the peroxide value observed were respectively of 41.8±0.8 Absorbance Unit (AU)/g oil and 254.3±5.8meq.O2/kg oil after 6months at 20°C. These values were of 18.2±1.3AU/g oil and 65.2±20.3meq.O2/kg after 6days at 60°C.

  10. Experience-Based Mitigation of Age-Related Performance Declines: Evidence from Air Traffic Control

    ERIC Educational Resources Information Center

    Nunes, Ashley; Kramer, Arthur F.

    2009-01-01

    Previous research has found age-related deficits in a variety of cognitive processes. However, some studies have demonstrated age-related sparing on tasks where individuals have substantial experience, often attained over many decades. Here, the authors examined whether decades of experience in a fast-paced demanding profession, air traffic…

  11. Kenyan Student-Teacher Counsellors' Creativity and Its Relationship with Their Gender, Age, and Teaching Experience

    ERIC Educational Resources Information Center

    Kinai, Theresia Kavuli

    2013-01-01

    The purpose of the study was: (1) assess creativity of postgraduate student-teacher counselors whose age range was 25-54 years old, and teaching experience of 4-25 years; and (2) to find out whether age, gender, and teaching experience influence creativity. Seventy-two participants (43 females and 29 males) responded to the ICAS (Ibadan Creativity…

  12. Effect of weaning age on hair sheep lamb and ewe production traits in an accelerated lambing system in the tropics.

    PubMed

    Godfrey, R W; Weis, A J

    2016-03-01

    This study was designed to evaluate the impact of weaning age on lamb and ewe productivity in an accelerated lambing system. St. Croix White (STX) and Dorper × St. Croix White (DRPX) lambs were assigned at birth based on breed, gender, and litter size to be weaned at 63 (Early-1; 106 lambs and 68 ewes) or 90 d of age (Late-1; 99 lambs and 60 ewes) in Exp.1 or at 63 (Early-2; 77 lambs and 57 ewes) or 120 d of age (Late-2; 75 lambs and 56 ewes) in Exp. 2. After weaning, lambs were weighed weekly and fed a concentrate ration (2% BW·lamb·d) while grazing guinea grass pastures. In Exp. 1, weaning weight was greater ( < 0.0001) for Late-1 lambs than for Early-1 lambs (14.6 ± 0.3 vs. 11.0 ± 0.3 kg, respectively) and greater ( < 0.008) for DRPX lambs than for STX lambs (13.9 ± 0.4 vs. 11.5 ± 0.4 kg, respectively). Litter weaning weight was greater ( < 0.004) for Late-1 ewes than for Early-1 ewes (20.9 ± 0.8 vs. 17.4 ± 0.8 kg, respectively). Ewe efficiency ([ewe BW at weaning/litter weaning weight] × 100) was greater ( < 0.004) for Late-1 ewes than for Early-1 ewes (50.7 ± 1.9 vs. 42.3 ± 1.8%, respectively). Lamb weight gain between 63 and 90 d of age was lower ( < 0.03) for Early-1 lambs than for Late-1 lambs (2.7 ± 0.2 vs. 3.6 ± 0.3 kg, respectively). In Exp. 2, weaning weight was greater ( < 0.0001) for Late-2 lambs than for Early-2 lambs (18.7 ± 0.4 vs. 11.8 ± 0.4 kg, respectively) and greater ( < 0.008) for DRPX lambs than for STX lambs (16.9 ± 0.5 vs. 13.3 ± 0.5 kg, respectively). Litter weaning weight was greater ( < 0.0001) in Late-2 ewes than in Early-2 ewes (27.2 ± 1.0 vs. 17.5 ± 0.9 kg, respectively). Ewe efficiency was greater ( < 0.0001) for Late-2 ewes than for Early-2 ewes (68.1 ± 2.2 vs. 41.9 ± 2.0%, respectively). Lamb weight gain between 63 and 120 d of age was not different ( > 0.06) between Early-2 and Late-2 lambs (5.1 ± 0.2 vs. 5.6 ± 0.3 kg, respectively). In Exp. 1 and 2, ewe BW at breeding and lambing and weaning and lambing

  13. Cigarette Smoking Accelerated Brain Aging and Induced Pre-Alzheimer-Like Neuropathology in Rats

    PubMed Central

    Ho, Yuen-Shan; Yang, Xifei; Yeung, Sze-Chun; Chiu, Kin; Lau, Chi-Fai; Tsang, Andrea Wing-Ting; Mak, Judith Choi-Wo; Chang, Raymond Chuen-Chung

    2012-01-01

    Cigarette smoking has been proposed as a major risk factor for aging-related pathological changes and Alzheimer's disease (AD). To date, little is known for how smoking can predispose our brains to dementia or cognitive impairment. This study aimed to investigate the cigarette smoke-induced pathological changes in brains. Male Sprague-Dawley (SD) rats were exposed to either sham air or 4% cigarette smoke 1 hour per day for 8 weeks in a ventilated smoking chamber to mimic the situation of chronic passive smoking. We found that the levels of oxidative stress were significantly increased in the hippocampus of the smoking group. Smoking also affected the synapse through reducing the expression of pre-synaptic proteins including synaptophysin and synapsin-1, while there were no changes in the expression of postsynaptic protein PSD95. Decreased levels of acetylated-tubulin and increased levels of phosphorylated-tau at 231, 205 and 404 epitopes were also observed in the hippocampus of the smoking rats. These results suggested that axonal transport machinery might be impaired, and the stability of cytoskeleton might be affected by smoking. Moreover, smoking affected amyloid precursor protein (APP) processing by increasing the production of sAPPβ and accumulation of β–amyloid peptide in the CA3 and dentate gyrus region. In summary, our data suggested that chronic cigarette smoking could induce synaptic changes and other neuropathological alterations. These changes might serve as evidence of early phases of neurodegeneration and may explain why smoking can predispose brains to AD and dementia. PMID:22606286

  14. Age effect on fatigue-induced limb acceleration as a consequence of high-level sustained submaximal contraction.

    PubMed

    Huang, Chien-Ting; Huang, Chien-Chun; Young, Ming-Shing; Hwang, Ing-Shiou

    2007-08-01

    In reference to electromyographic measurement, the study was conducted to reassess differences in the behavior of fatigue-related neuromuscular function between young and elderly humans with limb acceleration (LA). Fourteen young and fourteen elderly subjects performed sustained index abduction at 75% of their maximal voluntary contractions (MVC) until task failure. Measures of neuromuscular function, including temporal/spectral features of muscle activity of the first dorsal interosseous (FDI) and LA of the index and hand, were monitored. The results showed a manifest fatigue-induced increase in LA of the index in the elderly group, but not in the young group. In contrast, only the young group developed a significant increase in amplitude of the electromyography (EMG) until task failure. Spectral analyses of LA in the index reflected marked age-dependent reorganization following muscle fatigue, with a greater reduction of relative spectral amplitude of LA in the range of 20-40 Hz, but a lesser reduction in coherence between EMG and LA in the elderly group. In line with fatigue-associated restructuring of LA, the mechanical coupling of the metacarpophalangeal joint was more severely undermined in the elderly group than in the young group. The present study manifested an age-related difference in the relative contributions of neural versus mechanical factors to muscle fatigue. Subsequent to a high-level sustained submaximal isometric contraction, a predominant mechanical failure of the musculotendon complex in the elderly was featured with LA, whereas EMG measurement characterized prevailing impairment of neuromuscular propagation in the young.

  15. From experiment to design -- Fault characterization and detection in parallel computer systems using computational accelerators

    NASA Astrophysics Data System (ADS)

    Yim, Keun Soo

    This dissertation summarizes experimental validation and co-design studies conducted to optimize the fault detection capabilities and overheads in hybrid computer systems (e.g., using CPUs and Graphics Processing Units, or GPUs), and consequently to improve the scalability of parallel computer systems using computational accelerators. The experimental validation studies were conducted to help us understand the failure characteristics of CPU-GPU hybrid computer systems under various types of hardware faults. The main characterization targets were faults that are difficult to detect and/or recover from, e.g., faults that cause long latency failures (Ch. 3), faults in dynamically allocated resources (Ch. 4), faults in GPUs (Ch. 5), faults in MPI programs (Ch. 6), and microarchitecture-level faults with specific timing features (Ch. 7). The co-design studies were based on the characterization results. One of the co-designed systems has a set of source-to-source translators that customize and strategically place error detectors in the source code of target GPU programs (Ch. 5). Another co-designed system uses an extension card to learn the normal behavioral and semantic execution patterns of message-passing processes executing on CPUs, and to detect abnormal behaviors of those parallel processes (Ch. 6). The third co-designed system is a co-processor that has a set of new instructions in order to support software-implemented fault detection techniques (Ch. 7). The work described in this dissertation gains more importance because heterogeneous processors have become an essential component of state-of-the-art supercomputers. GPUs were used in three of the five fastest supercomputers that were operating in 2011. Our work included comprehensive fault characterization studies in CPU-GPU hybrid computers. In CPUs, we monitored the target systems for a long period of time after injecting faults (a temporally comprehensive experiment), and injected faults into various types of

  16. Teaching And Training Tools For The Undergraduate: Experience With A Rebuilt AN-400 Accelerator

    SciTech Connect

    Roberts, Andrew D.

    2011-06-01

    There is an increasingly recognized need for people trained in a broad range of applied nuclear science techniques, indicated by reports from the American Physical Society and elsewhere. Anecdotal evidence suggests that opportunities for hands-on training with small particle accelerators have diminished in the US, as development programs established in the 1960's and 1970's have been decommissioned over recent decades. Despite the reduced interest in the use of low energy accelerators in fundamental research, these machines can offer a powerful platform for bringing unique training opportunities to the undergraduate curriculum in nuclear physics, engineering and technology. We report here on the new MSU Applied Nuclear Science Lab, centered around the rebuild of an AN400 electrostatic accelerator. This machine is run entirely by undergraduate students under faculty supervision, allowing a great deal of freedom in its use without restrictions from graduate or external project demands.

  17. Special Review: Accelerating fracture repair in humans: a reading of old experiments and recent clinical trials

    PubMed Central

    Aspenberg, Per

    2013-01-01

    Based on their mode of action and preclinical data, one would expect bisphosphonates to improve the healing of fractures in cancellous bone, and bone morphogenetic proteins (BMPs) to reduce the risk of non-union in severe shaft fractures. Parathyreoid hormone (PTH) can be expected to accelerate fracture healing in general. The clinical data in support of this is meager. Stimulation of cancellous bone healing and strength by bisphosphonates has been inadvertently shown in the context of implant fixation, but not convincingly in fractures per se. The clinical BMP literature is confusing, and the chance of ever demonstrating reduced numbers of non-union are small, due to power issues. Still, acceleration of ‘normal' healing may be possible, but largely remains to show. For PTH, the two available clinical trials both show accelerated healing, but none of them is flawless, and there is a need for better studies. PMID:24404375

  18. Wizards and scientists: the pharmacologic experience in the Middle Ages.

    PubMed

    Rossi, F; Mangrella, M; Loffreda, A; Lampa, E

    1994-01-01

    During the Dark ages, Greco-Roman science survived in the eastern Roman Empire and the most important advances in pharmacology and pharmacy were made in Byzantium. As the Arab empires spread in the 7th and 8th centuries, they incorporated earlier learning, and the most important contribution of Arabic medical writers was probably the introduction of formularies to aid in the preparation of medicines. In turn, the later spread of Arabic knowledge to the West introduced little-known plants and fostered an interest in collecting and cultivating them, and also introduced the palatable dose forms preferred by the Arabic doctors. In the West, however, the Christian Church taught a doctrine of unquestioning faith, and despite the centers of learning, e.g. at Salerno, most ordinary people depended on the healing power of faith, religious relics and traditional folk medicine. Hydrology was also well developed in the Middle Ages. The formularia that survive describe many indigenous plants, but with few illustrations. Their gathering and preparation is generally guided by magic ceremonies and ritual, and plants often took their properties from their habitat, e.g. the wayside plantain was thought good for tired or wounded feet. Concepts of therapeutic plants were also influenced by alchemy and were linked to related metals and planets. PMID:7847474

  19. Planned High-brightness Channeling Radiation Experiment at Fermilab's Advanced Superconducting Test Accelerator

    SciTech Connect

    Blomberg, Ben; Mihalcea, Daniel; Panuganti, Harsha; Piot, Philippe; Brau, Charles; Choi, Bo; Gabella, William; Ivanov, Borislav; Mendenhall, Marcus; Lynn, Christopher; Sen, Tanaji; Wagner, Wolfgang

    2014-07-01

    In this contribution we describe the technical details and experimental setup of our study aimed at producing high-brightness channeling radiation (CR) at Fermilab’s new user facility the Advanced Superconducting Test Accelerator (ASTA). In the ASTA photoinjector area electrons are accelerated up to 40-MeV and focused to a sub-micron spot on a ~40 micron thick carbon diamond, the electrons channel through the crystal and emit CR up to 80-KeV. Our study utilizes ASTA’s long pulse train capabilities and ability to preserve ultra-low emittance, to produce the desired high average brightness.

  20. Construction, commissioning and operational experience of the Advanced Photon Source (APS) linear accelerator

    SciTech Connect

    White, M.; Arnold, N.; Berg, W.

    1996-10-01

    The Advanced Photon Source linear accelerator system consists of a 200 MeV, 2856 MHz S-Band electron linac and a 2-radiation-thick tungsten target followed by a 450 MeV positron linac. The linac system has operated 24 hours per day for the past year to support accelerator commissioning and beam studies and to provide beam for the user experimental program. It achieves the design goal for positron current of 8 mA and produces electron energies up to 650 MeV without the target in place. The linac is described and its operation and performance are discussed.

  1. Cell inactivation, repair and mutation induction in bacteria after heavy ion exposure: results from experiments at accelerators and in space.

    PubMed

    Horneck, G; Schafer, M; Baltschukat, K; Weisbrod, U; Micke, U; Facius, R; Bucker, H

    1989-01-01

    To understand the mechanisms of accelerated heavy ions on biological matter, the responses of spores of B. subtilis to this structured high LET radiation was investigated applying two different approaches. 1) By the use of the Biostack concept, the inactivation probability as a function of radial distance to single particles' trajectory (i.e. impact parameter) was determined in space experiments as well as at accelerators using low fluences of heavy ions. It was found that spores can survive even a central hit and that the effective range of inactivation extends far beyond impact parameters where inactivation by delta-ray dose would be effective. Concerning the space experiment, the inactivation cross section exceeds those from comparable accelerator experiments by roughly a factor of 20. 2) From fluence effect curves, cross sections for inactivation and mutation induction, and the efficiency of repair processes were determined. They are influenced by the ions characteristics in a complex manner. According to dependence on LET, at least 3 LET ranges can be differentiated: A low LET range (app. < 200 keV/micrometers), where cross sections for inactivation and mutation induction follow a common curve for different ions and where repair processes are effective; an intermediate LET range of the so-called saturation cross section with negligible mutagenic and repair efficiency; and a high LET range (>1000 keV/micrometers) where the biological endpoints are majorly dependent on atomic mass and energy of the ion under consideration. PMID:11537282

  2. Narcolepsy in pediatric age - Experience of a tertiary pediatric hospital.

    PubMed

    Dias Costa, Filipa; Barreto, Maria Inês; Clemente, Vanda; Vasconcelos, Mónica; Estêvão, Maria Helena; Madureira, Núria

    2014-03-01

    Narcolepsy, a chronic disorder of the sleep-wake cycle of multifactorial etiology, is characterized by excessive daytime sleepiness, often associated with cataplexy, hypnagogic/hypnopompic hallucinations and sleep paralysis. Both early clinical suspicion and therapeutic approach are essential for promotion of cognitive development and social integration of these children. The authors present a descriptive retrospective study of a series of eight children in whom symptoms first started between 6.8 and 10.5 years of age. Diagnostic delay ranged from 4 months to 2 years. One child had H1N1 flu vaccination eight months before the clinical onset. The first multiple sleep latency test was positive in 6 of 8 cases. All cases were treated with methylphenidate, and venlafaxine was associated in 4 of them. In one case the initial therapy was exclusively behavioral. In all cases, symptomatic improvement, better school performance and social integration were achieved after therapeutic adjustment. PMID:26483902

  3. Accelerating Opportunity: A Portrait of Students and Their Program Experiences from the 2014 Student Survey

    ERIC Educational Resources Information Center

    Spaulding, Shayne; Martin-Caughey, Ananda

    2015-01-01

    This report presents findings from a survey of students enrolled in Accelerating Opportunity (AO) career pathways in spring 2014. AO provides grants to help community colleges create career pathway programs to enroll students with low basic skills into for-credit career and technical education courses to improve educational and employment…

  4. Elementary-aged children's aesthetic experiences with music.

    PubMed

    Paul, Phyllis M

    2008-01-01

    This study examined the perceived aesthetic experiences of elementary school children. Sixty 4th graders, from 3 intact public school classes that included students identified as gifted and with special needs, listened to 'Rhapsody on a Theme of Paganini, Op. 43, Variation 18,' by Rachmaninoff and simultaneously indicated responses by manipulating a Continuous Response Digital Interface (CRDI) dial. One week later, participants repeated the listening activity under identical experimental conditions. As in similar studies with adults, aggregated graphic analyses showed that many of the children's highest and lowest reactions tended to cluster at the same places, and test-retest reliability showed a high positive correspondence between the two listening sessions (r = .99). Although it is impossible to know if these 4th graders actually had aesthetic experiences, it seems clear that they did respond to this music. It was determined that 57 students, including most of those with special needs, successfully used the CRDI dial to indicate their reactions and 58 expressed comfort with the simplicity of its use. Additional analyses, which compared responses based on developmental statuses, found a wide range of correlations between children who were categorized as normally developing, gifted, or having special needs.

  5. Highly accelerated cardiac MRI using iterative SENSE reconstruction: initial clinical experience.

    PubMed

    Allen, Bradley D; Carr, Maria; Botelho, Marcos P F; Rahsepar, Amir Ali; Markl, Michael; Zenge, Michael O; Schmidt, Michaela; Nadar, Mariappan S; Spottiswoode, Bruce; Collins, Jeremy D; Carr, James C

    2016-06-01

    To evaluate the qualitative and quantitative performance of an accelerated cardiovascular MRI (CMR) protocol that features iterative SENSE reconstruction and spatio-temporal L1-regularization (IS SENSE). Twenty consecutively recruited patients and 9 healthy volunteers were included. 2D steady state free precession cine images including 3-chamber, 4-chamber, and short axis slices were acquired using standard parallel imaging (GRAPPA, acceleration factor = 2), spatio-temporal undersampled TSENSE (acceleration factor = 4), and IS SENSE techniques (acceleration factor = 4). Acquisition times, quantitative cardiac functional parameters, wall motion abnormalities (WMA), and qualitative performance (scale: 1-poor to 5-excellent for overall image quality, noise, and artifact) were compared. Breath-hold times for IS SENSE (3.0 ± 0.6 s) and TSENSE (3.3 ± 0.6) were both reduced relative to GRAPPA (8.4 ± 1.7 s, p < 0.001). No difference in quantitative cardiac function was present between the three techniques (p = 0.89 for ejection fraction). GRAPPA and IS SENSE had similar image quality (4.7 ± 0.4 vs. 4.5 ± 0.6, p = 0.09) while, both techniques were superior to TSENSE (quality: 4.1 ± 0.7, p < 0.001). GRAPPA WMA agreement with IS SENSE was good (κ > 0.60, p < 0.001), while agreement with TSENSE was poor (κ < 0.40, p < 0.001). IS SENSE is a viable clinical CMR acceleration approach to reduce acquisition times while maintaining satisfactory qualitative and quantitative performance. PMID:26894256

  6. Hosing Instability of the Drive Electron Beam in the E157 Plasma-Wakefield Acceleration Experiment at the Stanford Linear Accelerator

    SciTech Connect

    Blue, Brent Edward; /SLAC /UCLA

    2005-10-10

    In the plasma-wakefield experiment at SLAC, known as E157, an ultra-relativistic electron beam is used to both excite and witness a plasma wave for advanced accelerator applications. If the beam is tilted, then it will undergo transverse oscillations inside of the plasma. These oscillations can grow exponentially via an instability know as the electron hose instability. The linear theory of electron-hose instability in a uniform ion column predicts that for the parameters of the E157 experiment (beam charge, bunch length, and plasma density) a growth of the centroid offset should occur. Analysis of the E157 data has provided four critical results. The first was that the incoming beam did have a tilt. The tilt was much smaller than the radius and was measured to be 5.3 {micro}m/{delta}{sub z} at the entrance of the plasma (IP1.) The second was the beam centroid oscillates in the ion channel at half the frequency of the beam radius (betatron beam oscillations), and these oscillations can be predicted by the envelope equation. Third, up to the maximum operating plasma density of E157 ({approx}2 x 10{sup 14} cm{sup -3}), no growth of the centroid offset was measured. Finally, time-resolved data of the beam shows that up to this density, no significant growth of the tail of the beam (up to 8ps from the centroid) occurred even though the beam had an initial tilt.

  7. Young Children's Learning of Novel Digital Interfaces: How Technology Experience, Age, and Design Come into Play

    ERIC Educational Resources Information Center

    Gilutz, Shuli

    2009-01-01

    This study looks at the relationship between age, technology experience, and design factors in determining young children's comprehension of novel digital interfaces. In Experiment 1, 35 preschoolers played three games that varied in complexity and familiarity. Parental questionnaires were used to assess children's previous technology experience.…

  8. Models of Metal-poor Stars with Gravitational Settling and Radiative Accelerations. II. The Age of the Oldest Stars

    NASA Astrophysics Data System (ADS)

    VandenBerg, Don A.; Richard, O.; Michaud, G.; Richer, J.

    2002-05-01

    Isochrones for ages between 12 and 18 Gyr have been derived from the evolutionary tracks presented in Paper I (Richard et al.) for masses from 0.5 to 1.0 Msolar and initial chemical abundances corresponding to (1) Y=0.2352, Z=1.69×10-4 ([Fe/H]=-2.31,[α/Fe]=0.3) and (2) Y=0.2370, Z=1.69×10-3 ([Fe/H=-1.31,[α/Fe]=0.3). These are the first models for Population II stars in which both gravitational settling and radiative accelerations have been taken into account. Allowance for these diffusive processes leads to a 10%-12% reduction in age at a given turnoff luminosity. However, in order for the diffusive models to satisfy the constraints from Li and Fe abundance data (see Paper I) and to reproduce the observed morphologies of globular cluster (GC) color-magnitude diagrams (CMDs) in a straightforward way, extra mixing just below the boundary of the convective envelope seems to be necessary. Indeed, when additional turbulent mixing is invoked, the resultant models are able to satisfy all of these constraints, as well as those provided by the CMDs of local subdwarfs, rather well. Moreover, they imply an age near 13.5 Gyr for M92, which is one of the most metal-deficient (and presumably one of the oldest) of the Galaxy's GCs, if the field subgiant HD 140283 is used to derive the cluster distance. Comparisons of field subdwarfs and subgiants with a recently published fiducial for M5 suggests that the cluster has [Fe/H]<~-1.4, in conflict with some estimates based on high-resolution spectroscopy, if the metallicities of the field stars are to be trusted. In addition, an age of ~11.5 Gyr is found for M5, irrespective of whether diffusive or nondiffusive isochrones are employed in the analysis. The implications of our results for the extragalactic distance scale and for the Hubble constant are briefly discussed in the context of the presently favored ΩM~0.35, ΩΛ~0.65 cosmological model.

  9. Dynamic mechanical and molecular weight measurements on polymer bonded explosives from thermally accelerated aging tests. I. Fluoropolymer binders

    SciTech Connect

    Hoffman, D.M.; Caley, L.E.

    1981-01-01

    The dynamic mechanical properties and molecular weight distribution of two polymer bonded explosives, LX-10-1 and PBX-9502, maintained at 23, 60, and 74/sup 0/C for 3 years were studied. LX-10-1 is 94.5% 1,3,5,7-tetranitro-1,3,5,7-tetraazacyclooctane explosive bonded together with 5.5% Viton A fluoropolymer. PBX-9502 is 95% triaminotrinitrobenzene explosive bonded with 5% Kel-F-800 fluoropolymer. There are two mechanical relaxations in the LX-10-1 in the military temperature range. The relaxation at -10/sup 0/C is associated with the glass transition temperature of the Viton A binder. A second weak relaxation occurs at about 30/sup 0/C in all LX-10-1 samples tested. This relaxation is probably associated with small amounts of crystallinity in the binder although this has not been demonstrated. There is a slight increase in modulus of the LX-10-1 with accelerated aging temperature. Changes in the dynamic mechanical properties of PBX-9502 are ascribed to crystallization of the chlorotrifluoroethylene component of the Kel-F-800 binder. The molecular weight of the Viton A binder decreased slight with increasing aging temperature. Using the kinetics of random scission the activation energy for polymer degradation in the presence of the explosive was 1.19 kcal/mole. The Arrhenius preexponential term and activation energy predict an expected use-life in excess of 60 years for LX-10-1. The Kel-F-800 in PBX-9502 is also extremely stable.

  10. X-Band Photonic Band-Gap Accelerator Structure Breakdown Experiment

    SciTech Connect

    Marsh, Roark A.; Shapiro, Michael A.; Temkin, Richard J.; Dolgashev, Valery A.; Laurent, Lisa L.; Lewandowski, James R.; Yeremian, A.Dian; Tantawi, Sami G.; /SLAC

    2012-06-11

    In order to understand the performance of photonic band-gap (PBG) structures under realistic high gradient, high power, high repetition rate operation, a PBG accelerator structure was designed and tested at X band (11.424 GHz). The structure consisted of a single test cell with matching cells before and after the structure. The design followed principles previously established in testing a series of conventional pillbox structures. The PBG structure was tested at an accelerating gradient of 65 MV/m yielding a breakdown rate of two breakdowns per hour at 60 Hz. An accelerating gradient above 110 MV/m was demonstrated at a higher breakdown rate. Significant pulsed heating occurred on the surface of the inner rods of the PBG structure, with a temperature rise of 85 K estimated when operating in 100 ns pulses at a gradient of 100 MV/m and a surface magnetic field of 890 kA/m. A temperature rise of up to 250 K was estimated for some shots. The iris surfaces, the location of peak electric field, surprisingly had no damage, but the inner rods, the location of the peak magnetic fields and a large temperature rise, had significant damage. Breakdown in accelerator structures is generally understood in terms of electric field effects. These PBG structure results highlight the unexpected role of magnetic fields in breakdown. The hypothesis is presented that the moderate level electric field on the inner rods, about 14 MV/m, is enhanced at small tips and projections caused by pulsed heating, leading to breakdown. Future PBG structures should be built to minimize pulsed surface heating and temperature rise.

  11. Simulation of the laser acceleration experiment at the Fermilab/NICADD photoinjector laboratory

    SciTech Connect

    Piot, P.; Tikhoplav, R.; Melissinos, A.C.; /Rochester U.

    2005-05-01

    The possibility of using laser beam to accelerate electrons in a waveguide structure with dimension much larger than the laser wavelength was proposed by Pantel and analytically investigated by Xie. In the present paper we present the status of our experimental plan to demonstrate the laser/e{sup -} interaction using an e{sup -} beam with initial energy of 40-50 MeV.

  12. Synthesis of iron fertilization experiments: From the Iron Age in the Age of Enlightenment

    NASA Astrophysics Data System (ADS)

    de Baar, Hein J. W.; Boyd, Philip W.; Coale, Kenneth H.; Landry, Michael R.; Tsuda, Atsushi; Assmy, Philipp; Bakker, Dorothee C. E.; Bozec, Yann; Barber, Richard T.; Brzezinski, Mark A.; Buesseler, Ken O.; Boyé, Marie; Croot, Peter L.; Gervais, Frank; Gorbunov, Maxim Y.; Harrison, Paul J.; Hiscock, William T.; Laan, Patrick; Lancelot, Christiane; Law, Cliff S.; Levasseur, Maurice; Marchetti, Adrian; Millero, Frank J.; Nishioka, Jun; Nojiri, Yukihiro; van Oijen, Tim; Riebesell, Ulf; Rijkenberg, Micha J. A.; Saito, Hiroaki; Takeda, Shigenobu; Timmermans, Klaas R.; Veldhuis, Marcel J. W.; Waite, Anya M.; Wong, Chi-Shing

    2005-09-01

    Comparison of eight iron experiments shows that maximum Chl a, the maximum DIC removal, and the overall DIC/Fe efficiency all scale inversely with depth of the wind mixed layer (WML) defining the light environment. Moreover, lateral patch dilution, sea surface irradiance, temperature, and grazing play additional roles. The Southern Ocean experiments were most influenced by very deep WMLs. In contrast, light conditions were most favorable during SEEDS and SERIES as well as during IronEx-2. The two extreme experiments, EisenEx and SEEDS, can be linked via EisenEx bottle incubations with shallower simulated WML depth. Large diatoms always benefit the most from Fe addition, where a remarkably small group of thriving diatom species is dominated by universal response of Pseudo-nitzschia spp. Significant response of these moderate (10-30 μm), medium (30-60 μm), and large (>60 μm) diatoms is consistent with growth physiology determined for single species in natural seawater. The minimum level of "dissolved" Fe (filtrate < 0.2 μm) maintained during an experiment determines the dominant diatom size class. However, this is further complicated by continuous transfer of original truly dissolved reduced Fe(II) into the colloidal pool, which may constitute some 75% of the "dissolved" pool. Depth integration of carbon inventory changes partly compensates the adverse effects of a deep WML due to its greater integration depths, decreasing the differences in responses between the eight experiments. About half of depth-integrated overall primary productivity is reflected in a decrease of DIC. The overall C/Fe efficiency of DIC uptake is DIC/Fe ˜ 5600 for all eight experiments. The increase of particulate organic carbon is about a quarter of the primary production, suggesting food web losses for the other three quarters. Replenishment of DIC by air/sea exchange tends to be a minor few percent of primary CO2 fixation but will continue well after observations have stopped. Export of

  13. High-fat diet intake accelerates aging, increases expression of Hsd11b1, and promotes lipid accumulation in liver of SAMP10 mouse.

    PubMed

    Honma, Taro; Shinohara, Nahoko; Ito, Junya; Kijima, Ryo; Sugawara, Soko; Arai, Tatsuya; Tsuduki, Tsuyoshi; Ikeda, Ikuo

    2012-04-01

    An understanding of the mechanisms of aging is important for prevention of age-related diseases. In this study, we examined age-dependent changes in lipid metabolism in the senescence-accelerated mouse (SAM)P10 fed a high-fat diet to investigate the effects of high-fat intake and aging. Tissue weights and biological parameters in plasma and liver were measured at 6 and 12 months old in SAMP10 mice fed a high-fat diet. These mice showed marked increases in liver triacylglycerol and plasma insulin levels with intake of a high-fat diet intake and aging. Lipid accumulation in hepatocytes and morphological aberrations and hypertrophy in pancreatic islets were also promoted by a high-fat diet and aging. To investigate the underlying mechanisms, the activities and mRNA levels for enzymes associated with lipid metabolism in liver were measured. The results indicated that the lipid metabolic system was activated by a high-fat diet and aging. Liver mRNA level for hydroxysteroid 11-beta dehydrogenase 1 (Hsd11b1), which exhibit age-dependent increases and promote insulin secretion, was also markedly increased. These results suggest that a high-fat diet accelerated aging in the liver of SAMP10 mice by increasing liver mRNA level for Hsd11b1, increasing insulin secretion, and promoting lipid accumulation in the liver.

  14. SRF Accelerator Technology Transfer Experience from the Achievement of the SNS Cryomodule Production Run

    SciTech Connect

    John Hogan; Ed Daly; Michael Drury; John Fischer; Tommy Hiatt; Peter Kneisel; John Mammosser; Joseph Preble; Timothy Whitlatch; Katherine Wilson; Mark Wiseman

    2005-05-01

    This paper will discuss the technology transfer aspect of superconducting RF expertise, as it pertains to cryomodule production, beginning with the original design requirements through testing and concluding with product delivery to the end user. The success of future industrialization, of accelerator systems, is dependent upon a focused effort on accelerator technology transfer. Over the past twenty years the Thomas Jefferson National Accelerator Facility (Jefferson Lab) has worked with industry to successfully design, manufacture, test and commission more superconducting RF cryomodules than any other entity in the world. The most recent accomplishment of Jefferson Lab has been the successful production of twenty-four cryomodules designed for the Spallation Neutron Source (SNS). Jefferson Lab was chosen, by the United States Department of Energy, to provide the superconducting portion of the SNS linac due to its reputation as a primary resource for SRF expertise. The successful partnering with, and development of, industrial resources to support the fabrication of the superconducting RF cryomodules for SNS by Jefferson Lab will be the focus of this paper.

  15. Appetite and falls: Old age and lived experiences

    PubMed Central

    Sarvimäki, Anneli

    2012-01-01

    Falling among older adults is a well-known public health problem but the association between falling and appetite is seldom studied although poor nutritional status is accepted as a risk factor for falls. On this background the aim of this study was to understand how older adults, who have fallen several times within a year, related their experiences of appetite as a phenomenon in everyday life. In narrative in-depth interviews, eight women and four men contributed with their stories. Using interpretative phenomenology the thematic analysis resulted in three main themes: appetite for food; appetite for social relations and appetite for influence. Eating was not trivial everyday routine and required self-regimentation. Meals were not an object of desire, but of discipline out of the wish to survive. Feelings, reflections and ambivalence were bound to the lack of appetite on food. The participants were oriented towards the forbidden, the delicious and to everyday food as a strengthener and as medicine. In their dependency on help, home was the framework for establishing social relations as means of social support. As well as family and neighbours, the significant others were persons on whom the participants were dependent. Personal relationships and mutual dependencies may ensure social security in lives characterised by contingency and maintain influence in daily life. Falling is both a dramatic and a trivial incident where life and death could be at stake. From this perspective, connectedness was prominent in all fall stories. The quest for influence and a sense of social connectedness was the incentive to re-enter local community arenas and to express solidarity. In health-care practice multi-factorial fall-prevention should be complemented with a multi-dimensional approach in order to balance the medical approach with humanistic and societal approaches towards fall-prevention. PMID:22389651

  16. Influence of Different Types of Resin Luting Agents on Color Stability of Ceramic Laminate Veneers Subjected to Accelerated Artificial Aging.

    PubMed

    Silami, Francisca Daniele Jardilino; Tonani, Rafaella; Alandia-Román, Carla Cecilia; Pires-de-Souza, Fernanda de Carvalho Panzeri

    2016-01-01

    The aim of this study was to evaluate the influence of accelerated aging (AAA) on the color stability of resin cements for bonding ceramic laminate veneers of different thicknesses. The occlusal surfaces of 80 healthy human molars were flattened. Ceramic laminate veneers (IPS e-max Ceram) of two thicknesses (0.5 and 1.0 mm) were bonded with three types of luting agents: light-cured, conventional dual and self-adhesive dual cement. Teeth without restorations and cement samples (0.5 mm) were used as control. After initial color evaluations, the samples were subjected to AAA for 580 h. After this, new color readouts were made, and the color stability (ΔE) and luminosity (ΔL) data were analyzed. The greatest color changes (p<0.05) occurred when 0.5 mm veneers were fixed with light-cured cement and the lowest when 1.0 mm veneers were fixed with conventional dual cement. There was no influence of the restoration thickness when the self-adhesive dual cement was used. When veneers were compared with the control groups, it was verified that the cement samples presented the greatest alterations (p<0.05) in comparison with both substrates and restored teeth. Therefore, it was concluded that the thickness of the restoration influences color and luminosity changes for conventional dual and light-cured cements. The changes in self-adhesive cement do not depend on restoration thickness.

  17. Folate Acts in E. coli to Accelerate C. elegans Aging Independently of Bacterial Biosynthesis

    PubMed Central

    Virk, Bhupinder; Jia, Jie; Maynard, Claire A.; Raimundo, Adelaide; Lefebvre, Jolien; Richards, Shane A.; Chetina, Natalia; Liang, Yen; Helliwell, Noel; Cipinska, Marta; Weinkove, David

    2016-01-01

    Summary Folates are cofactors for biosynthetic enzymes in all eukaryotic and prokaryotic cells. Animals cannot synthesize folate and must acquire it from their diet or microbiota. Previously, we showed that inhibiting E. coli folate synthesis increases C. elegans lifespan. Here, we show that restriction or supplementation of C. elegans folate does not influence lifespan. Thus, folate is required in E. coli to shorten worm lifespan. Bacterial proliferation in the intestine has been proposed as a mechanism for the life-shortening influence of E. coli. However, we found no correlation between C. elegans survival and bacterial growth in a screen of 1,000+ E. coli deletion mutants. Nine mutants increased worm lifespan robustly, suggesting specific gene regulation is required for the life-shortening activity of E. coli. Disrupting the biosynthetic folate cycle did not increase lifespan. Thus, folate acts through a growth-independent route in E. coli to accelerate animal aging. PMID:26876180

  18. Influence of Different Types of Resin Luting Agents on Color Stability of Ceramic Laminate Veneers Subjected to Accelerated Artificial Aging.

    PubMed

    Silami, Francisca Daniele Jardilino; Tonani, Rafaella; Alandia-Román, Carla Cecilia; Pires-de-Souza, Fernanda de Carvalho Panzeri

    2016-01-01

    The aim of this study was to evaluate the influence of accelerated aging (AAA) on the color stability of resin cements for bonding ceramic laminate veneers of different thicknesses. The occlusal surfaces of 80 healthy human molars were flattened. Ceramic laminate veneers (IPS e-max Ceram) of two thicknesses (0.5 and 1.0 mm) were bonded with three types of luting agents: light-cured, conventional dual and self-adhesive dual cement. Teeth without restorations and cement samples (0.5 mm) were used as control. After initial color evaluations, the samples were subjected to AAA for 580 h. After this, new color readouts were made, and the color stability (ΔE) and luminosity (ΔL) data were analyzed. The greatest color changes (p<0.05) occurred when 0.5 mm veneers were fixed with light-cured cement and the lowest when 1.0 mm veneers were fixed with conventional dual cement. There was no influence of the restoration thickness when the self-adhesive dual cement was used. When veneers were compared with the control groups, it was verified that the cement samples presented the greatest alterations (p<0.05) in comparison with both substrates and restored teeth. Therefore, it was concluded that the thickness of the restoration influences color and luminosity changes for conventional dual and light-cured cements. The changes in self-adhesive cement do not depend on restoration thickness. PMID:27007354

  19. Acceleration of aged-landfill stabilization by combining partial nitrification and leachate recirculation: a field-scale study.

    PubMed

    Chung, Jinwook; Kim, Seungjin; Baek, Seungcheon; Lee, Nam-Hoon; Park, Seongjun; Lee, Junghun; Lee, Heechang; Bae, Wookeun

    2015-03-21

    Leachate recirculation for rapid landfill stabilization can result in the accumulation of high-strength ammonium. An on-site sequencing batch reactor (SBR) was therefore, applied to oxidize the ammonium to nitrite, which was then recirculated to the landfill for denitrification to nitrogen gas. At relatively higher ammonium levels, nitrite accumulated well in the SBR; the nitrite was denitrified stably in the landfill, despite an insufficient biodegradable carbon source in the leachate. As the leachate was recirculated, the methane and carbon dioxide contents produced from the landfill fluctuated, implying that the organic acids and hydrogen produced in the acid production phase acted as the carbon source for denitrification in the landfill. Leachate recirculation combined with ex-situ partial nitrification of the leachate may enhance the biodegradation process by: (a) removing the nitrogen that is contained with the leachate, and (b) accelerating landfill stabilization, because the biodegradation efficiency of landfill waste is increased by supplying sufficient moisture and its byproducts are used as the carbon source for denitrification. In addition, partial nitrification using an SBR has advantages for complete denitrification in the landfill, since the available carbon source is in short supply in aged landfills.

  20. Folate Acts in E. coli to Accelerate C. elegans Aging Independently of Bacterial Biosynthesis.

    PubMed

    Virk, Bhupinder; Jia, Jie; Maynard, Claire A; Raimundo, Adelaide; Lefebvre, Jolien; Richards, Shane A; Chetina, Natalia; Liang, Yen; Helliwell, Noel; Cipinska, Marta; Weinkove, David

    2016-02-23

    Folates are cofactors for biosynthetic enzymes in all eukaryotic and prokaryotic cells. Animals cannot synthesize folate and must acquire it from their diet or microbiota. Previously, we showed that inhibiting E. coli folate synthesis increases C. elegans lifespan. Here, we show that restriction or supplementation of C. elegans folate does not influence lifespan. Thus, folate is required in E. coli to shorten worm lifespan. Bacterial proliferation in the intestine has been proposed as a mechanism for the life-shortening influence of E. coli. However, we found no correlation between C. elegans survival and bacterial growth in a screen of 1,000+ E. coli deletion mutants. Nine mutants increased worm lifespan robustly, suggesting specific gene regulation is required for the life-shortening activity of E. coli. Disrupting the biosynthetic folate cycle did not increase lifespan. Thus, folate acts through a growth-independent route in E. coli to accelerate animal aging.

  1. Evidence for reduced experience-dependent dendritic spine plasticity in the aging prefrontal cortex

    PubMed Central

    Bloss, Erik B.; Janssen, William G.; Ohm, Daniel T.; Yuk, Frank J.; Wadsworth, Shannon; Saardi, Karl M.; McEwen, Bruce S.; Morrison, John H.

    2011-01-01

    Cognitive functions that require the prefrontal cortex are highly sensitive to aging in humans, non-human primates, and rodents, although the neurobiological correlates of this vulnerability remain largely unknown. It has been proposed that dendritic spines represent the primary site of structural plasticity in the adult brain, and recent data have supported the hypothesis that aging is associated with alterations of dendritic spine morphology and plasticity in prefrontal cortex. However, no study to date has directly examined whether aging alters the capacity for experience-dependent spine plasticity in aging prefrontal neurons. To address this possibility we used young, middle-aged, and aged rats in a behavioral stress paradigm known to produce spine remodeling in prefrontal cortical neurons. In young rats, stress resulted in dendritic spine loss and altered patterns of spine morphology; in contrast, spines from middle-aged and aged animals were remarkably stable and did not show evidence of remodeling. The loss of stress-induced spine plasticity observed in aging rats occurred alongside robust age-related reductions in spine density and shifts in remaining spine morphology. Taken together, the data presented here provide the first evidence that experience-dependent spine plasticity is altered by aging in prefrontal cortex, and support a model in which dendritic spines become progressively less plastic in the aging brain. PMID:21613496

  2. Correlates of Root Caries Experience in Middle-Aged and Older Adults within the Northwest PRECEDENT

    PubMed Central

    Chi, Donald L.; Berg, Joel H.; Kim, Amy S.; Scott, JoAnna

    2014-01-01

    STRUCTURED ABSTRACT Background We examined the correlates of root caries experience for middle-aged (ages 45–64 years) and older adults (ages 65+ years) to test the hypothesis that the factors related to root caries are different for middle-aged versus older adults. Methods This observational cross-sectional study focused on adult patients ages 45–97 years recruited from the Northwest PRECEDENT (N=775 adults). The outcome variable was any root caries experience (no/yes). Sociodemographic, intraoral, and behavioral factors were hypothesized as potential root caries correlates. We used Poisson regression models to generate overall and age-stratified prevalence ratios (PR) of root caries and Generalized Estimating Equations to account for practice-level clustering of participants. Results About 20% of adults had any root caries. Dentists’ assessment that the patient was at high risk for any caries was associated with greater prevalence of root caries experience in both middle-aged adults (PR=2.70, 95% CI: 1.63,4.46) and older adults (PR=1.87, 95% CI: 1.19,2.95). The following factors were significantly associated with increased root caries prevalence, but only for middle-aged adults: male sex (P=.02), self-reported dry mouth (P<.0001), exposed roots (P=.03), and increased frequency of eating or drinking between meals (P=.03). No other covariates were related to root caries experience for older adults. Conclusions Within a practice-based research network, the factors associated with root caries experience were different for middle-aged and older adults. Future work should identify relevant root caries correlates for adults ages 65+ years. Clinical Implications Interventions aimed at preventing root caries are likely to be different for middle-aged and older adults. Root caries prevention programs should address the appropriate aged-based risk factors. PMID:23633699

  3. Childhood Parasomnias and Psychotic Experiences at Age 12 Years in a United Kingdom Birth Cohort

    PubMed Central

    Fisher, Helen L.; Lereya, Suzet Tanya; Thompson, Andrew; Lewis, Glyn; Zammit, Stanley; Wolke, Dieter

    2014-01-01

    Study Objectives: To examine associations between specific parasomnias and psychotic experiences in childhood. Design: Birth cohort study. Information on the presence of frequent nightmares in children was obtained prospectively from mothers during multiple assessments conducted when children were aged between 2.5 and 9 y. Children were interviewed at age 12 y about nightmares, night terrors, sleepwalking, and psychotic experiences (delusions, hallucinations, and thought interference) occurring in the previous 6 mo. Setting: Assessments were completed in participants' homes or a University clinic within the UK. Patients or Participants: There were 6,796 children (3,462 girls, 50.9%) who completed the psychotic experiences interview. Measurements and Results: Children who were reported by their mothers as experiencing frequent nightmares between 2.5 and 9 y of age were more likely to report psychotic experiences at age 12 y, regardless of sex, family adversity, emotional or behavioral problems, IQ and potential neurological problems (odds ratio (OR) = 1.16, [95% confidence intervals (CI) = 1.00, 1.35], P = 0.049). Children reporting any of the parasomnias at age 12 y also had higher rates of concurrent psychotic experiences than those without such sleeping problems, when adjusting for all confounders (OR = 3.62 [95% CI = 2.57, 5.11], P < 0.001). Difficulty getting to sleep and night waking were not found to be associated with psychotic experiences at age 12 y when controlling for confounders. Conclusion: Nightmares and night terrors, but not other sleeping problems, in childhood were associated with psychotic experiences at age 12 years. These findings tentatively suggest that arousal and rapid eye movement forms of sleep disorder might be early indicators of susceptibility to psychotic experiences. Citation: Fisher HL; Lereya ST; Thompson A; Lewis G; Zammit S; Wolke D. Childhood parasomnias and psychotic experiences at age 12 years in a United Kingdom birth cohort

  4. Conceptual design of a 1013 -W pulsed-power accelerator for megajoule-class dynamic-material-physics experiments

    NASA Astrophysics Data System (ADS)

    Stygar, W. A.; Reisman, D. B.; Stoltzfus, B. S.; Austin, K. N.; Ao, T.; Benage, J. F.; Breden, E. W.; Cooper, R. A.; Cuneo, M. E.; Davis, J.-P.; Ennis, J. B.; Gard, P. D.; Greiser, G. W.; Gruner, F. R.; Haill, T. A.; Hutsel, B. T.; Jones, P. A.; LeChien, K. R.; Leckbee, J. J.; Lewis, S. A.; Lucero, D. J.; McKee, G. R.; Moore, J. K.; Mulville, T. D.; Muron, D. J.; Root, S.; Savage, M. E.; Sceiford, M. E.; Spielman, R. B.; Waisman, E. M.; Wisher, M. L.

    2016-07-01

    We have developed a conceptual design of a next-generation pulsed-power accelerator that is optimized for megajoule-class dynamic-material-physics experiments. Sufficient electrical energy is delivered by the accelerator to a physics load to achieve—within centimeter-scale samples—material pressures as high as 1 TPa. The accelerator design is based on an architecture that is founded on three concepts: single-stage electrical-pulse compression, impedance matching, and transit-time-isolated drive circuits. The prime power source of the accelerator consists of 600 independent impedance-matched Marx generators. Each Marx comprises eight 5.8-GW bricks connected electrically in series, and generates a 100-ns 46-GW electrical-power pulse. A 450-ns-long water-insulated coaxial-transmission-line impedance transformer transports the power generated by each Marx to a system of twelve 2.5-m-radius water-insulated conical transmission lines. The conical lines are connected electrically in parallel at a 66-cm radius by a water-insulated 45-post sextuple-post-hole convolute. The convolute sums the electrical currents at the outputs of the conical lines, and delivers the combined current to a single solid-dielectric-insulated radial transmission line. The radial line in turn transmits the combined current to the load. Since much of the accelerator is water insulated, we refer to it as Neptune. Neptune is 40 m in diameter, stores 4.8 MJ of electrical energy in its Marx capacitors, and generates 28 TW of peak electrical power. Since the Marxes are transit-time isolated from each other for 900 ns, they can be triggered at different times to construct-over an interval as long as 1 μ s -the specific load-current time history required for a given experiment. Neptune delivers 1 MJ and 20 MA in a 380-ns current pulse to an 18 -m Ω load; hence Neptune is a megajoule-class 20-MA arbitrary waveform generator. Neptune will allow the international scientific community to conduct dynamic

  5. The effects of age and experience on memory for visually presented music.

    PubMed

    Meinz, E J; Salthouse, T A

    1998-01-01

    Increased age is often associated with lower levels of performance in tests of memory for spatial information. The primary question in the current study was whether this relationship could be moderated as a function of one's relevant experience and/or knowledge. Stimulus materials consisted of short (7-11 note), visually presented musical melodies and structurally equivalent nonmusical stimuli. Participants (N = 128) were recruited from a wide range of age and experience levels. Although there were strong main effects of age and experience on memory for music, there was no evidence that the age-related differences in memory for these stimuli were smaller for individuals with moderate to large amounts of experience with music. PMID:9469173

  6. Experiences in the Bilingual Education of a Child of Pre-School Age

    ERIC Educational Resources Information Center

    Zierer, Ernesto

    1977-01-01

    This article reports on experiences in the bilingual education, psychologically and pedagogically planned, of a child who died of brain cancer at age 5. Conclusions are drawn regarding order and method of language learning. (CHK)

  7. Conceptual designs of two petawatt-class pulsed-power accelerators for high-energy-density-physics experiments

    NASA Astrophysics Data System (ADS)

    Stygar, W. A.; Awe, T. J.; Bailey, J. E.; Bennett, N. L.; Breden, E. W.; Campbell, E. M.; Clark, R. E.; Cooper, R. A.; Cuneo, M. E.; Ennis, J. B.; Fehl, D. L.; Genoni, T. C.; Gomez, M. R.; Greiser, G. W.; Gruner, F. R.; Herrmann, M. C.; Hutsel, B. T.; Jennings, C. A.; Jobe, D. O.; Jones, B. M.; Jones, M. C.; Jones, P. A.; Knapp, P. F.; Lash, J. S.; LeChien, K. R.; Leckbee, J. J.; Leeper, R. J.; Lewis, S. A.; Long, F. W.; Lucero, D. J.; Madrid, E. A.; Martin, M. R.; Matzen, M. K.; Mazarakis, M. G.; McBride, R. D.; McKee, G. R.; Miller, C. L.; Moore, J. K.; Mostrom, C. B.; Mulville, T. D.; Peterson, K. J.; Porter, J. L.; Reisman, D. B.; Rochau, G. A.; Rochau, G. E.; Rose, D. V.; Rovang, D. C.; Savage, M. E.; Sceiford, M. E.; Schmit, P. F.; Schneider, R. F.; Schwarz, J.; Sefkow, A. B.; Sinars, D. B.; Slutz, S. A.; Spielman, R. B.; Stoltzfus, B. S.; Thoma, C.; Vesey, R. A.; Wakeland, P. E.; Welch, D. R.; Wisher, M. L.; Woodworth, J. R.

    2015-11-01

    suggest Z 300 will deliver 4.3 MJ to the liner, and achieve a yield on the order of 18 MJ. Z 800 is 52 m in diameter and stores 130 MJ. This accelerator generates 890 TW at the output of its LTD system, and delivers 65 MA in 113 ns to a MagLIF target. The peak electrical power at the MagLIF liner is 2500 TW. The principal goal of Z 800 is to achieve high-yield thermonuclear fusion; i.e., a yield that exceeds the energy initially stored by the accelerator's capacitors. 2D MHD simulations suggest Z 800 will deliver 8.0 MJ to the liner, and achieve a yield on the order of 440 MJ. Z 300 and Z 800, or variations of these accelerators, will allow the international high-energy-density-physics community to conduct advanced inertial-confinement-fusion, radiation-physics, material-physics, and laboratory-astrophysics experiments over heretofore-inaccessible parameter regimes.

  8. Aging of nuclear station diesel generators: Evaluation of operating and expert experience: Phase 1, Study

    SciTech Connect

    Hoopingarner, K.R.; Vause, J.W.; Dingee, D.A.; Nesbitt, J.F.

    1987-08-01

    Pacific Northwest Laboratory evaluated operational and expert experience pertaining to the aging degradation of diesel generators in nuclear service. The research, sponsored by the US Nuclear Regulatory Commission (NRC), identified and characterized the contribution of aging to emergency diesel generator failures. This report, Volume I, reviews diesel-generator experience to identify the systems and components most subject to aging degradation and isolates the major causes of failure that may affect future operational readiness. Evaluations show that as plants age, the percent of aging-related failures increases and failure modes change. A compilation is presented of recommended corrective actions for the failures identified. This study also includes a review of current, relevant industry programs, research, and standards. Volume II reports the results of an industry-wide workshop held on May 28 and 29, 1986 to discuss the technical issues associated with aging of nuclear service emergency diesel generators.

  9. POLAR 5 - An electron accelerator experiment within an aurora. III - Evidence for significant spacecraft charging by an electron accelerator at ionospheric altitudes

    NASA Technical Reports Server (NTRS)

    Jacobsen, T. A.; Maynard, N. C.

    1980-01-01

    The POLAR 5 rocket experiment carried an electron accelerator on a 'daughter' payload which injected a 0.1 A beam of 10 keV electrons in a pulsed mode every 410 ms. With spin and precession, injections were made over a wide range of pitch angles. Measurements from a double probe electric field instrument and from particle detectors on the 'mother' payload and from a crude RPA on the 'daughter' payload are interpreted to indicate that the 'daughter' charges to a potential between several hundred volts and 1 kV. The neutralizing return current to the 'daughter' is shown to be asymmetrically distributed with the majority being collected from the direction of the beam. The additional electrons necessary to neutralize the daughter are thought to be produced and heated through beam-plasma interactions postulated by Maehlum et al. (1980) and Grandal et al. (1980) to explain the particle and optical measurements. Significant electric fields emanating from the charged 'daughter' and the beam are seen at distances exceeding 100 m at the 'mother' payload.

  10. Empathetic Responses and Attitudes about Older Adults: How Experience with the Aging Game Measures up

    ERIC Educational Resources Information Center

    Henry, Beverly W.; Ozier, Amy D.; Johnson, Amy

    2011-01-01

    This study aimed to assess the impact of pre-professional education on students' knowledge and attitudes about aging, including the option of a simulated learning activity. Using a mixed design, groups of nursing and nutrition students (n = 127) were randomly assigned to experience the Aging Game. Pre- and posttest observations included measures…

  11. Adolescents' Definitions of Bullying: The Contribution of Age, Gender, and Experience of Bullying

    ERIC Educational Resources Information Center

    Byrne, Hollie; Dooley, Barbara; Fitzgerald, Amanda; Dolphin, Louise

    2016-01-01

    The aim of the present research was to examine adolescents' definitions of bullying in a nationally representative sample of adolescents in Ireland. Definitions of bullying were examined according to age, gender, and bullying experiences. A sample of 4358 adolescents aged 12-19 years (M = 14.99 years, SD = 1.63) provided their definitions of…

  12. Relationship of Age, Marital Status, and Work Experience of Community College Nursing Students to Grades.

    ERIC Educational Resources Information Center

    Frerichs, Marian L.

    To investigate differences in academic success due to age (younger or older than age 23), marital status, and nursing experience, a three-way analysis of variance was performed on the grade point averages of 1,435 female nursing students enrolled in 22 Associate Degree Nursing (ADN) programs in Illinois. The sample, representing over 90 percent of…

  13. Closing the Gap between Experiment and Theory: Crystal Growth by Temperature Accelerated Dynamics

    SciTech Connect

    Montalenti, F.; Sorensen, M. R.; Voter, A. F.

    2001-09-17

    We present atomistic simulations of crystal growth where realistic experimental deposition rates are reproduced, without needing any a priori information on the relevant diffusion processes. Using the temperature accelerated dynamics method, we simulate the deposition of 4 monolayers (ML) of Ag/Ag(100) at the rate of 0.075 ML/s, thus obtaining a boost of several orders of magnitude with respect to ordinary molecular dynamics. In the temperature range analyzed (0--70 K), steering and activated mechanisms compete in determining the surface roughness.

  14. Beam dynamics studies for the relativistic klystron two-beam accelerator experiment

    SciTech Connect

    Lidia, Steven M.

    2001-06-22

    Two-beam accelerators based upon relativistic klystron s (RK s) have been proposed as power sources for future generation linear electron-positron colliders. These drivers are known to suffer from several transverse beam break-up (BBU) instabilities. A program to study a particular technique (the betatron node scheme ) for ameliorating the high frequency BBU is under way at LBNL. Central to this study are the pillbox RF cavities and RF beam position monitors (BPM s) employed. This paper describes the design, fabrication, and testing of the RF components. Performance details during operation are also discussed.

  15. Polar 5 - An electron accelerator experiment within an aurora. I - Instrumentation and geophysical conditions

    NASA Technical Reports Server (NTRS)

    Maehlum, B. N.; Grandal, B.; Jacobsen, T. A.; Maseide, K.; Egeland, A.; Holtet, J.; Soraas, F.; Aarsnes, K.; Stadsnes, J.; Maynard, N. C.

    1980-01-01

    A mother-daughter rocket was launched over two auroral structures, which included a 10 keV electron accelerator and a series of diagnostic instruments for monitoring optical and wave effects generated through beam-atmospheric interactions and production of secondary electrons. The instrumentation, the ground and rocket background measurements obtained, and some of the beam effects on various geophysical parameters are presented. Attention is given to the rocket geometry, capacitance probe, particle counters, photometers, and the bremsstrahlung X-ray detector. Observations on the plasma environment, auroral particle precipitation, d.c. electric field, optical emissions, and auroral background HF and VLF emissions are also discussed.

  16. In vitro analysis of different properties of acrylic resins for ocular prosthesis submitted to accelerated aging with or without photopolymerized glaze.

    PubMed

    Santos, Daniela Micheline Dos; Nagay, Bruna Egumi; da Silva, Emily Vivianne Freitas; Bonatto, Liliane da Rocha; Sonego, Mariana Vilela; Moreno, Amália; Rangel, Elidiane Cipriano; da Cruz, Nilson Cristino; Goiato, Marcelo Coelho

    2016-12-01

    The effect of a photopolymerized glaze on different properties of acrylic resin (AR) for ocular prostheses submitted to accelerated aging was investigated. Forty discs were divided into 4 groups: N1 AR without glaze (G1); colorless AR without glaze (G2); N1 AR with glaze (G3); and colorless AR with glaze (G4). All samples were polished with sandpaper (240, 600 and 800-grit). In G1 and G2, a 1200-grit sandpaper was also used. In G3 and G4, samples were coated with MegaSeal glaze. Property analysis of color stability, microhardness, roughness, and surface energy, and assays of atomic force microscopy, scanning electron microscopy, and energy-dispersive spectroscopy were performed before and after the accelerated aging (1008h). Data were submitted to the ANOVA and Tukey Test (p<0.05). Groups with glaze exhibited statistically higher color change and roughness after aging. The surface microhardness significantly decreased in groups with glaze and increased in groups without glaze. The surface energy increased after the aging, independent of the polishing procedure. All groups showed an increase of surface irregularities. Photopolymerized glaze is an inadequate surface treatment for AR for ocular prostheses and it affected the color stability, roughness, and microhardness. The accelerated aging interfered negatively with the properties of resins. PMID:27612795

  17. In vitro analysis of different properties of acrylic resins for ocular prosthesis submitted to accelerated aging with or without photopolymerized glaze.

    PubMed

    Santos, Daniela Micheline Dos; Nagay, Bruna Egumi; da Silva, Emily Vivianne Freitas; Bonatto, Liliane da Rocha; Sonego, Mariana Vilela; Moreno, Amália; Rangel, Elidiane Cipriano; da Cruz, Nilson Cristino; Goiato, Marcelo Coelho

    2016-12-01

    The effect of a photopolymerized glaze on different properties of acrylic resin (AR) for ocular prostheses submitted to accelerated aging was investigated. Forty discs were divided into 4 groups: N1 AR without glaze (G1); colorless AR without glaze (G2); N1 AR with glaze (G3); and colorless AR with glaze (G4). All samples were polished with sandpaper (240, 600 and 800-grit). In G1 and G2, a 1200-grit sandpaper was also used. In G3 and G4, samples were coated with MegaSeal glaze. Property analysis of color stability, microhardness, roughness, and surface energy, and assays of atomic force microscopy, scanning electron microscopy, and energy-dispersive spectroscopy were performed before and after the accelerated aging (1008h). Data were submitted to the ANOVA and Tukey Test (p<0.05). Groups with glaze exhibited statistically higher color change and roughness after aging. The surface microhardness significantly decreased in groups with glaze and increased in groups without glaze. The surface energy increased after the aging, independent of the polishing procedure. All groups showed an increase of surface irregularities. Photopolymerized glaze is an inadequate surface treatment for AR for ocular prostheses and it affected the color stability, roughness, and microhardness. The accelerated aging interfered negatively with the properties of resins.

  18. Differences in gait velocity and trunk acceleration during semicircular turning gait with and without bag in females of very advanced age.

    PubMed

    Shin, Sun-Shil; Yoo, Won-Gyu

    2016-08-01

    [Purpose] Gait velocity and trunk acceleration during semicircular turning gait with and without carrying a hand-held bag were compared in females of very advanced age. [Subjects and Methods] Ten female volunteers of very advanced age who could walk independently were recruited for this study. Gait velocity and trunk acceleration were measured using an accelerometer during semicircular turning gait with and without carrying a hand-held bag. [Results] Gait velocity during semicircular turning gait was greater with the bag than without the bag. [Conclusions] Trunk stability during semicircular turning gait was higher when the subjects carried a bag. Additional arm load could be considered during gait training in females of very advanced age. PMID:27630425

  19. Differences in gait velocity and trunk acceleration during semicircular turning gait with and without bag in females of very advanced age

    PubMed Central

    Shin, Sun-Shil; Yoo, Won-Gyu

    2016-01-01

    [Purpose] Gait velocity and trunk acceleration during semicircular turning gait with and without carrying a hand-held bag were compared in females of very advanced age. [Subjects and Methods] Ten female volunteers of very advanced age who could walk independently were recruited for this study. Gait velocity and trunk acceleration were measured using an accelerometer during semicircular turning gait with and without carrying a hand-held bag. [Results] Gait velocity during semicircular turning gait was greater with the bag than without the bag. [Conclusions] Trunk stability during semicircular turning gait was higher when the subjects carried a bag. Additional arm load could be considered during gait training in females of very advanced age. PMID:27630425

  20. Differences in gait velocity and trunk acceleration during semicircular turning gait with and without bag in females of very advanced age

    PubMed Central

    Shin, Sun-Shil; Yoo, Won-Gyu

    2016-01-01

    [Purpose] Gait velocity and trunk acceleration during semicircular turning gait with and without carrying a hand-held bag were compared in females of very advanced age. [Subjects and Methods] Ten female volunteers of very advanced age who could walk independently were recruited for this study. Gait velocity and trunk acceleration were measured using an accelerometer during semicircular turning gait with and without carrying a hand-held bag. [Results] Gait velocity during semicircular turning gait was greater with the bag than without the bag. [Conclusions] Trunk stability during semicircular turning gait was higher when the subjects carried a bag. Additional arm load could be considered during gait training in females of very advanced age.