Science.gov

Sample records for accelerated development sessions

  1. 76 FR 28988 - Medicare Program; Accelerated Development Sessions for Accountable Care Organizations-June 20, 21...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-19

    ... Sessions for Accountable Care Organizations--June 20, 21, and 22, 2011 AGENCY: Centers for Medicare... functions of an Accountable Care Organization (ACO) and ways to build their organization's capacity to succeed as an ACO. This 3-day, in-person ADS is to help new ACOs deliver better care and reduce costs....

  2. Summary of the electron accelerators session

    SciTech Connect

    Prescott, C.Y. )

    1989-05-05

    Since the last High Energy Physics Symposium, there has been considerable progress in the field of polarized electron accelerators. Projects well into construction include the SLC, HERA, and LEP. The status of polarized beams for these projects is discussed in this session. Semiclassical and quantum mechanical calculations of polarizing and depolarizing effects are discussed, for both linear colliders and for storage rings. Substantial progress is continuing in the understanding of depolarizing mechanisms for circular machines. Modelling of these machines is underway. Activities with polarized electron beams at Novosibirsk are described.

  3. Summary of the electron accelerators session

    SciTech Connect

    Prescott, C.Y.

    1988-10-01

    Since the last High Energy Physics Symposium, there has been considerable progress in the field of polarized electron accelerators. Projects well into construction include the SLC, HERA, and LEP. The status of polarized beams for these projects is discussed in this session. Semiclassical and quantum mechanical calculations of polarizing and depolarizing effects are discussed, for both linear colliders and for storage rings. Substantial progress is continuing in the understanding of depolarizing mechanisms for circular machines. Modelling of these machines is underway. Activities with polarized electron beams at Novosibirsk are described. 8 refs.

  4. Session: Wind industry project development

    SciTech Connect

    Gray, Tom; Enfield, Sam

    2004-09-01

    This first session at the Wind Energy and Birds/Bats workshop consisted of two presentations followed by a question and answer period. The session was intended to provide a general overview of wind energy product development, from the industry's perspective. Tom Gray of AWEA presented a paper titled ''State of the Wind Energy Industry in 2004'', highlighting improved performance and lower cost, efforts to address avian impacts, a status of wind energy in comparison to other energy-producing sources, and ending on expectations for the near future. Sam Enfield of Atlantic Renewable Energy Corporation presented a paper titled ''Key Factors for Consideration in Wind Plant Siting'', highlighting factors that wind facility developers must consider when choosing a site to build wind turbines and associated structures. Factors covered include wind resources available, ownership and land use patterns, access to transmission lines, accessibility and environmental impacts. The question and answer sum mary included topics related to risk taking, research and development, regulatory requirements, and dealing with utilities.

  5. Developing assessment: involving the sessional clinical teacher.

    PubMed

    Bateman, H; Thomason, J M; McCracken, G; Ellis, J

    2016-02-12

    Assessment development is a fundamental element of curriculum management and a requirement for providers of education to consistently demonstrate attainment of educational standards. Development of authentic, valid and reliable assessment is, however, both challenging and resource intensive. In the UK, dental education standards are regulated by the General Dental Council (GDC). The 'safe beginner' is the threshold determined by the GDC for the passing student - but how do we apply this? This article describes an approach the School of Dental Sciences at Newcastle University has adopted to address the challenges associated with developing assessments. Sessional clinical teachers contribute a significant proportion of the clinical supervision within the BDS programme and also have a good appreciation of both the standard and concept of the 'safe beginner'. By implementing a process of active timetable management, we have identified time where this group could contribute to assessment development. We believe that aspects, which could be enhanced by their involvement, include writing, validation, standard-setting and utilisation of assessment. To achieve this, we recognise a requirement for investment in careful manpower planning and training, but consider that it is realistic and beneficial to include sessional clinical teachers in this essential part of learning and teaching.

  6. Session: Pre-development project risk assessment

    SciTech Connect

    Curry, Richard; Linehan, Andy

    2004-09-01

    This second session at the Wind Energy and Birds/Bats workshop consisted of two presentations followed by a discussion/question and answer period. The focus of the presentations was on the practices and methodologies used in the wind energy industry for assessing risk to birds and bats at candidate project sites. Presenters offered examples of pre-development siting evaluation requirements set by certain states. Presentation one was titled ''Practices and Methodologies and Initial Screening Tools'' by Richard Curry of Curry and Kerlinger, LLC. Presentation two was titled ''State of the Industry in the Pacific Northwest'' by Andy Linehan, CH2MHILL.

  7. Accelerated Management Development

    ERIC Educational Resources Information Center

    Munn, Kenn

    1974-01-01

    Western Electric's accelerated management development program for hand picked college graduate students consists of a high risk training project in which the management candidate accomplishes his task or is terminated. The success of such projects puts candidates in third level management in seven years or half the normal time. (DS)

  8. Advanced accelerator theory development

    SciTech Connect

    Sampayan, S.E.; Houck, T.L.; Poole, B.; Tishchenko, N.; Vitello, P.A.; Wang, I.

    1998-02-09

    A new accelerator technology, the dielectric wall accelerator (DWA), is potentially an ultra compact accelerator/pulsed power driver. This new accelerator relies on three new components: the ultra-high gradient insulator, the asymmetric Blumlein and low jitter switches. In this report, we focused our attention on the first two components of the DWA system the insulators and the asymmetric Blumlein. First, we sought to develop the necessary design tools to model and scale the behavior of the high gradient insulator. To perform this task we concentrated on modeling the discharge processes (i.e., initiation and creation of the surface discharge). In addition, because these high gradient structures exhibit favorable microwave properties in certain accelerator configurations, we performed experiments and calculations to determine the relevant electromagnetic properties. Second, we performed circuit modeling to understand energy coupling to dynamic loads by the asymmetric Blumlein. Further, we have experimentally observed a non-linear coupling effect in certain asymmetric Blumlein configurations. That is, as these structures are stacked into a complete module, the output voltage does not sum linearly and a lower than expected output voltage results. Although we solved this effect experimentally, we performed calculations to understand this effect more fully to allow better optimization of this DWA pulse-forming line system.

  9. API Development for Persistent Data Sessions Support

    DTIC Science & Technology

    2005-03-01

    for persistent sessions. This testing is conducted on a wired environment to reconnect the FTP, RTSP or Telnet respectively. If time permits, the...example of a low level interface used by application programmers is the Berkeley Sockets interface which UNIX systems support [5]. 19 Many...types of protocols involved for the session. Real Time Streaming Protocol ( RTSP ) and Real Time Protocol (RTP) . RTSP is used for video control

  10. Professional development session for early career scientists at SITC 2012

    PubMed Central

    2013-01-01

    The Society for Immunotherapy of Cancer (SITC) 2012 Professional Development Session was held as part of the SITC 27th Annual Meeting, Washington, DC, on October 24, 2012. The session was designed as a new opportunity for early career investigators to learn about relevant career development topics in a didactic setting. PMID:25742323

  11. Programme Development. Paper Presentations: Session F.

    ERIC Educational Resources Information Center

    2000

    This document contains 35 papers from the program development section of an international conference on vocational education and training (VET) for lifelong learning in the information era. The following are among the papers included: "Using Quality Indicators to Create World-Class Curricula: From Concept to Application" (Curtis Finch,…

  12. Embryonic development during chronic acceleration

    NASA Technical Reports Server (NTRS)

    Smith, A. H.; Abbott, U. K.

    1982-01-01

    Experiments carried out on chicken eggs indicate that the embryo is affected during very early development, especially over the first four days, and during hatching. In the first four days, the brain develops as well as the anlage for all other organs. In addition, the heart commences to function and the extraembryonic membranes that compartmentalize the egg contents form. The latter require an appreciable extension and folding of tissue which may be disrupted by the mechanical load. Observations of embryonic abnormalities that occur during chronic acceleration suggest an inhibition of development of the axial skeleton, which is rarely seen otherwise, a general retardation of embryonic growth, and circulatory problems. The final stages of development (after 18 days) involve the uptake of fluids, the transition to aerial respiration, and the reorientation of the embryo into a normal hatching position. At 4 G mortality is very high during this period, with a majority of embryos failing to reorient into the normal hatching position.

  13. UCLA accelerator research and development

    SciTech Connect

    Cline, D.B.

    1992-01-01

    This progress report covers work supported by the above DOE grant over the period November 1, 1991 to July 31, 1992. The work is a program of experimental and theoretical studies in advanced particle accelerator research and development for high energy physics applications. The program features research at particle beam facilities in the United States and includes research on novel high power sources, novel focussing systems (e.g. plasma lens), beam monitors, novel high brightness, high current gun systems, and novel flavor factories in particular the {phi} Factory.

  14. Pomegranate Supplementation Accelerates Recovery of Muscle Damage and Soreness and Inflammatory Markers after a Weightlifting Training Session

    PubMed Central

    Ammar, Achraf; Turki, Mouna; Chtourou, Hamdi; Hammouda, Omar; Trabelsi, Khaled; Kallel, Choumous; Abdelkarim, Osama; Hoekelmann, Anita; Bouaziz, Mohamed; Ayadi, Fatma; Driss, Tarak; Souissi, Nizar

    2016-01-01

    Purpose The aim of this study was to investigate the effect of natural Pomegranate juice supplementation on performance and acute and delayed responses of muscle soreness and biomarkers of muscle damage after a weightlifting training session. Methods Nine elite weightlifters (21±0.5 years) performed two Olympic-Weightlifting-sessions after either placebo (PLA) or natural pomegranate juice (POMj) supplementations. Heart rate, blood pressure and blood samples (hematological parameters, muscle damage and C-reactive protein (CRP)) were collected at rest, 3min and 48h after each session. Weightlifting performance, RPE, and DOMS were also assessed after each training session. Results T-test showed higher performance (+8.30%) and lower RPE values (-4.37%) using POMj supplementation (p<0.05) in comparison with PLA. For the DOMS values, a significant improvement (13.4%) was shown only for the knee extensors (p<0.01) using the POMj. Compared to PLA condition, POMj attenuated the acute (i.e., 3min) increase of systolic blood pressure (SBP), HR, CK and LDH (p<0.05; -4.46%, -1.81%, -8.75%, -1.64%, respectively) and blunted the significant increase of ASAT, PAL and CRP (p>0.05). Additionally, during the 48h following the training session, POMj improved the recovery kinetic of SBP (p<0.01, 7.97%), CK (p<0.001, 11.34%), LDH (p<0.05, 7.30%) and ASAT (p<0.05, 6.77%). Indeed, the present study showed that 48h of recovery associated to natural POMj supplementation was sufficient to reach the resting values of the selected muscle damage markers after intensive training session. Conclusion Natural POMj seems to ameliorate the capacity to adhere to an intensive training program. Therefore, elite weightlifters are advised to use natural POMj during intensive training program and competition to accelerate muscle recovery. Trial Registration ClinicalTrials.gov NCT02697903 PMID:27764091

  15. A single aerobic exercise session accelerates movement execution but not central processing.

    PubMed

    Beyer, Kit B; Sage, Michael D; Staines, W Richard; Middleton, Laura E; McIlroy, William E

    2017-03-27

    Previous research has demonstrated that aerobic exercise has disparate effects on speed of processing and movement execution. In simple and choice reaction tasks, aerobic exercise appears to increase speed of movement execution while speed of processing is unaffected. In the flanker task, aerobic exercise has been shown to reduce response time on incongruent trials more than congruent trials, purportedly reflecting a selective influence on speed of processing related to cognitive control. However, it is unclear how changes in speed of processing and movement execution contribute to these exercise-induced changes in response time during the flanker task. This study examined how a single session of aerobic exercise influences speed of processing and movement execution during a flanker task using electromyography to partition response time into reaction time and movement time, respectively. Movement time decreased during aerobic exercise regardless of flanker congruence but returned to pre-exercise levels immediately after exercise. Reaction time during incongruent flanker trials decreased over time in both an aerobic exercise and non-exercise control condition indicating it was not specifically influenced by exercise. This disparate influence of aerobic exercise on movement time and reaction time indicates the importance of partitioning response time when examining the influence of aerobic exercise on speed of processing. The decrease in reaction time over time independent of aerobic exercise indicates that interpreting pre-to-post exercise changes in behavior requires caution.

  16. Session: What can we learn from developed wind resource areas

    SciTech Connect

    Thelander, Carl; Erickson, Wally

    2004-09-01

    This session at the Wind Energy and Birds/Bats workshop was composed of two parts intended to examine what existing science tells us about wind turbine impacts at existing wind project sites. Part one dealt with the Altamont Wind Resource area, one of the older wind projects in the US, with a paper presented by Carl Thelander titled ''Bird Fatalities in the Altamont Pass Wind Resource Area: A Case Study, Part 1''. Questions addressed by the presenter included: how is avian habitat affected at Altamont and do birds avoid turbine sites; are birds being attracted to turbine strings; what factors contribute to direct impacts on birds by wind turbines at Altamont; how do use, behavior, avoidance and other factors affect risk to avian species, and particularly impacts those species listed as threatened, endangered, or of conservation concern, and other state listed species. The second part dealt with direct impacts to birds at new generation wind plants outside of California, examining such is sues as mortality, avoidance, direct habitat impacts from terrestrial wind projects, species and numbers killed per turbine rates/MW generated, impacts to listed threatened and endangered species, to USFWS Birds of Conservation Concern, and to state listed species. This session focused on newer wind project sites with a paper titled ''Bird Fatality and Risk at New Generation Wind Projects'' by Wally Erickson. Each paper was followed by a discussion/question and answer period.

  17. Induction accelerator development for heavy ion fusion

    SciTech Connect

    Reginato, L.L.

    1993-05-01

    For approximately a decade, the Heavy Ion Fusion Accelerator Research (HIFAR) group at LBL has been exploring the use of induction accelerators with multiple beams as the driver for inertial fusion targets. Scaled experiments have investigated the transport of space charge dominated beams (SBTE), and the current amplification and transverse emittance control in induction linacs (MBE-4) with very encouraging results. In order to study many of the beam manipulations required by a driver and to further develop economically competitive technology, a proposal has been made in partnership with LLNL to build a 10 MeV accelerator and to conduct a series of experiments collectively called the Induction Linac System Experiments (ILSE). The major components critical to the ILSE accelerator are currently under development. We have constructed a full scale induction module and we have tested a number of amorphous magnetic materials developed by Allied Signal to establish an overall optimal design. The electric and magnetic quadrupoles critical to the transport and focusing of heavy ion beams are also under development The hardware is intended to be economically competitive for a driver without sacrificing any of the physics or performance requirements. This paper will concentrate on the recent developments and tests of the major components required by the ILSE accelerator.

  18. Accelerating development of advanced inverters :

    SciTech Connect

    Neely, Jason C.; Gonzalez, Sigifredo; Ropp, Michael; Schutz, Dustin

    2013-11-01

    The high penetration of utility interconnected photovoltaic (PV) systems is causing heightened concern over the effect that variable renewable generation will have on the electrical power system (EPS). These concerns have initiated the need to amend the utility interconnection standard to allow advanced inverter control functionalities that provide: (1) reactive power control for voltage support, (2) real power control for frequency support and (3) better tolerance of grid disturbances. These capabilities are aimed at minimizing the negative impact distributed PV systems may have on EPS voltage and frequency. Unfortunately, these advanced control functions may interfere with island detection schemes, and further development of advanced inverter functions requires a study of the effect of advanced functions on the efficacy of antiislanding schemes employed in industry. This report summarizes the analytical, simulation and experimental work to study interactions between advanced inverter functions and anti-islanding schemes being employed in distributed PV systems.

  19. Accelerated Leadership Development: Fast Tracking School Leaders

    ERIC Educational Resources Information Center

    Earley, Peter; Jones, Jeff

    2010-01-01

    "Accelerated Leadership Development" captures and communicates the lessons learned from successful fast-track leadership programmes in the private and public sector, and provides a model which schools can follow and customize as they plan their own leadership development strategies. As large numbers of headteachers and other senior staff…

  20. High average power linear induction accelerator development

    SciTech Connect

    Bayless, J.R.; Adler, R.J.

    1987-07-01

    There is increasing interest in linear induction accelerators (LIAs) for applications including free electron lasers, high power microwave generators and other types of radiation sources. Lawrence Livermore National Laboratory has developed LIA technology in combination with magnetic pulse compression techniques to achieve very impressive performance levels. In this paper we will briefly discuss the LIA concept and describe our development program. Our goals are to improve the reliability and reduce the cost of LIA systems. An accelerator is presently under construction to demonstrate these improvements at an energy of 1.6 MeV in 2 kA, 65 ns beam pulses at an average beam power of approximately 30 kW. The unique features of this system are a low cost accelerator design and an SCR-switched, magnetically compressed, pulse power system. 4 refs., 7 figs.

  1. Vehicle Systems Integration Laboratory Accelerates Powertrain Development

    ScienceCinema

    None

    2016-07-12

    ORNL's Vehicle Systems Integration (VSI) Laboratory accelerates the pace of powertrain development by performing prototype research and characterization of advanced systems and hardware components. The VSI Lab is capable of accommodating a range of platforms from advanced light-duty vehicles to hybridized Class 8 powertrains with the goals of improving overall system efficiency and reducing emissions.

  2. Recruiting and Developing HRDQ Reviewers: Why You Should Do It and What You Should Look For. Innovative Session.

    ERIC Educational Resources Information Center

    Squillaci, Christine M.; Russ-Eft, Darlene F.; Hatcher, Timothy G.; Rocco, Tonette S.; Yang, Baiyin

    The recruitment and development of reviewers for the Academy of Human Resource Development's (AHRD) research journal, "Human Resources Development Quarterly" (HRDQ), was examined at an innovative session of the 2002 AHRD conference. The session was conducted by five members of HRDQ's editorial board. The session objectives were as…

  3. Target and accelerator developments at CTI

    NASA Astrophysics Data System (ADS)

    Alvord, C. W.; Mendez, A. J.; Wittner, D. E.

    2001-07-01

    The accelerator products marketed by CTI have exclusively focused on proton-only, low energy (11 MeV) designs. This choice best suited the research customer, interested in producing several doses a day of a variety of positron emitting compounds. The PET cyclotron market has evolved into a high output, cost driven, competitive radiotracer production environment. A thoughtful analysis of the choices of energy and particle reveals that an 11 MeV proton accelerator outfitted with target changers and automated target loading and unloading equipment is still the best choice for FDG distribution. However technological innovations are required to face the challenges of the rapidly growing PET radiotracer business. Modifications to the CTI line of accelerators developed to face this evolving need will be presented.

  4. Human Resource Development and Manpower Training. Paper Presentations: Session B.

    ERIC Educational Resources Information Center

    2000

    This document contains 18 papers from the human resource development and manpower training section of an international conference on vocational education and training (VET) for lifelong learning in the information era. The following papers are included: "Use of Social and Economic Modeling to Plan Vocational Education and Training"…

  5. Management Development. [Concurrent Symposium Session at AHRD Annual Conference, 1998.

    ERIC Educational Resources Information Center

    1998

    This document contains four papers from a symposium on management development. "The Effect of Supervisor/Subordinate Relationship on Subordinate Performance, Role Ambiguity and Conflict, and Job Satisfaction" (Michael J. Nocera, Judith A. Kolb) finds that a strong perceived relationship with supervisors was negatively correlated with…

  6. Accelerated vaccine development against emerging infectious diseases.

    PubMed

    Leblanc, Pierre R; Yuan, Jianping; Brauns, Tim; Gelfand, Jeffrey A; Poznansky, Mark C

    2012-07-01

    Emerging and re-emerging infectious diseases represent a major challenge to vaccine development since it involves two seemingly contradictory requirements. Rapid and flexible vaccine generation while using technologies and processes that can facilitate accelerated regulatory review. Development in the "-omics" in combination with advances in vaccinology offer novel opportunities to meet these requirements. Here we describe how a consortium of five different organizations from academia and industry is addressing these challenges. This novel approach has the potential to become the new standard in vaccine development allowing timely deployment to avert potential pandemics.

  7. Developing acceleration schedules for NDCX-II

    SciTech Connect

    Sharp, W.M.; Friedman, A.; Grote, D.P.; Henestroza, E.; Leitner, M.A.; Waldron, W.L.

    2008-08-01

    The Virtual National Laboratory for Heavy-Ion Fusion Science is developing a physics design for NDCX-II, an experiment to study warm dense matter heated by ions near the Bragg-peak energy. Present plans call for using about thirty induction cells to accelerate 30 nC of Li+ ions to more than 3 MeV, followed by neutralized drift-compression. To heat targets to useful temperatures, the beam must be compressed to a millimeter-scale radius and a duration of about 1 ns. An interactive 1-D particle-in-cell simulation with an electrostatic field solver, acceleration-gap fringe fields, and a library of realizable analytic waveforms has been used for developing NDCX-II acceleration schedules. Axisymmetric simulations with WARP have validated this 1-D model and have been used both to design transverse focusing and to compensate for injection non-uniformities and radial variation of the fields. Highlights of this work are presented here.

  8. Accelerator Structure Development for NLC/GLC

    SciTech Connect

    Wang, J

    2004-03-05

    The NLC (Next Linear Collider) and GLC (Global Linear Collider) [1,2] are e{sup +}e{sup -} linear collider proposals based on room-temperature accelerator technology--so called ''warm machines'' in comparison with the TESLA ''cold machine'' that is based on superconducting accelerator technology. There have been two major challenges in developing X-band (11.4 GHz) accelerator structures for the GLC/NLC. The first is to demonstrate stable, long-term operation at the high gradient (65 MV/m) that is required to optimize the machine cost. The second is to strongly suppress the beam induced long-range wakefields, which is required to achieve high luminosity. The development of high gradient structures has been a high priority in recent years. Nearly thirty X-band structures with various rf parameters, cavity shapes and coupler types have been fabricated and tested since 2000. This program has been a successful collaborative effort among groups at SLAC, KEK, FNAL and other labs. A summary of the main achievements and experiences are presented in this paper as well as a status report on the structure design, high power performance, manufacturing techniques, and other structure related issues.

  9. Guidelines for Developing an Academic Acceleration Policy

    ERIC Educational Resources Information Center

    Colangelo, Nicholas; Assouline, Susan G.; Marron, Maureen A.; Castellano, Jaime A.; Clinkenbeard, Pamela R.; Rogers, Karen; Calvert, Eric; Malek, Rosanne; Smith, Donnajo

    2010-01-01

    As an educational intervention, acceleration is decidedly effective for high-ability students. The research support for acceleration that has accumulated over many decades is robust and consistent and allows us to confidently state that carefully planned acceleration decisions are successful. Both grade-based and content-based acceleration are…

  10. Vanguard industrial linear accelerator rapid product development

    NASA Astrophysics Data System (ADS)

    Harroun, Jim

    1994-07-01

    Siemens' ability to take the VanguardTM Industrial Linear Accelerator from the development stage to the market place in less than two years is described. Emphasis is on the development process, from the business plan through the shipment of the first commercial sale. Included are discussions on the evolution of the marketing specifications, with emphasis on imaging system requirements, as well as flexibility for expansion into other markets. Requirements used to create the engineering specifications, how they were incorporated into the design, and lessons learned from the demonstration system are covered. Some real-life examples of unanticipated problems are presented, as well as how they were resolved, including some discussion of the special problems encountered in developing a user interface and a training program for an international customer.

  11. Using Quality Enhancement Processes to Achieve Sustainable Development and Support for Sessional Staff

    ERIC Educational Resources Information Center

    Lekkas, D.; Winning, T. A.

    2017-01-01

    Consistent with quality enhancement, we report on how we used a continuous improvement cycle to formalise and embed an academic development and support programme for our School's sessional staff. Key factors in establishing and maintaining the programme included: local change agents supported initially by institutional project funding; School…

  12. Sessional Academic Success: A Distributed Framework for Academic Support and Development

    ERIC Educational Resources Information Center

    Hamilton, Jillian; Fox, Michelle; McEwan, Mitchell

    2013-01-01

    With approximately half of Australian university teaching now performed by Sessional Academics, there has been growing recognition of the contribution they make to student learning. At the same time, sector-wide research and institutional audits continue to raise concerns about academic development, quality assurance, recognition and belonging…

  13. Developments in accelerators for heavy ion fusion

    SciTech Connect

    Keefe, D.

    1985-05-01

    The long term goal of Heavy Ion Fusion (HIF) is the development of an accelerator with the large beam power, large beam stored-energy, and high brightness needed to implode small deuterium-tritium capsules for fusion power. While studies of an rf linac/storage ring combination as an inertial fusion driver continue in Japan and Europe, the US program in recent times has concentrated on the study of the suitability of linear induction acceleration of ions for this purpose. Novel features required include use of multiple beams, beam current amplification in the linac, and manipulation of long beam bunches with a large velocity difference between head and tail. Recent experiments with an intense bright beam of cesium ions have established that much higher currents can be transported in a long quadrupole system than was believed possible a few years ago. A proof-of-principle ion induction linac to demonstrate beam current amplification with multiple beams is at present being fabricated at LBL. 28 refs., 4 figs.

  14. Neutron Diagnostic Development for the Z Accelerator

    NASA Astrophysics Data System (ADS)

    Hahn, Kelly; Chandler, G. A.; Ruiz, C. L.; Jones, B.; Gomez, M. R.; Knapp, P. F.; Sefkow, A. B.; Hansen, S. B.; Schmit, P. F.; Harding, E. C.; Norris, E.; Torres, J. A.; Cooper, G. W.; Styron, J. D.; Frenje, J.; Lahmann, B.; Gatu-Johnson, M.; Seguin, F.; Petrasso, R.; Fittinghoff, D.; May, M.; Snyder, L.; Moy, K.; Buckles, R.; Glebov, V. Yu.

    2016-10-01

    We are studying Magnetized Liner Inertial Fusion (MagLIF) and Gas Puff fusion neutron sources on the Z accelerator. MagLIF experiments have produced up to 3e12 primary DD neutrons with 2-3 keV ion temperatures and 1-2 ns burn widths. Gas puff experiments have produced up to 5e13 primary DD neutrons with higher ion temperatures, longer burn times, and evidence of non-thermonuclear production. For MagLIF, the yield is expected to increase rapidly with increased energy coupling, yet it remains unclear if Gas Puffs would scale as attractively. We review neutron measurements for these experiments and plans for developing neutron diagnostics for these two very different sources. Sandia is sponsored by the U.S. DOE's NNSA under contract DE-AC04-94AL85000.

  15. Accelerating Adverse Outcome Pathway (AOP) development ...

    EPA Pesticide Factsheets

    The Adverse Outcome Pathway (AOP) framework is increasingly being adopted as a tool for organizing and summarizing the mechanistic information connecting molecular perturbations by environmental stressors with adverse outcomes relevant for ecological and human health outcomes. However, the conventional process for assembly of these AOPs is time and resource intensive, and has been a rate limiting step for AOP use and development. Therefore computational approaches to accelerate the process need to be developed. We previously developed a method for generating computationally predicted AOPs (cpAOPs) by association mining and integration of data from publicly available databases. In this work, a cpAOP network of ~21,000 associations was established between 105 phenotypes from TG-GATEs rat liver data from different time points (including microarray, pathological effects and clinical chemistry data), 994 REACTOME pathways, 688 High-throughput assays from ToxCast and 194 chemicals. A second network of 128,536 associations was generated by connecting 255 biological target genes from ToxCast to 4,980 diseases from CTD using either HT screening activity from ToxCast for 286 chemicals or CTD gene expression changes in response to 2,330 chemicals. Both networks were separately evaluated through manual extraction of disease-specific cpAOPs and comparison with expert curation of the relevant literature. By employing data integration strategies that involve the weighting of n

  16. Session: Development and application of guidelines for siting, constructing, operating and monitoring wind turbines

    SciTech Connect

    Manville, Albert; Hueckel, Greg

    2004-09-01

    This session at the Wind Energy and Birds/Bats workshop consisted of two presentations followed by a discussion/question and answer period. The two papers were: 'Development and Application of USFWS Guidance for Site Evaluation, Siting, Construction, Operation and Monitoring of Wind Turbines' by Albert Manville and 'Wind Power in Washington State' by Greg Hueckel. The session provided a comparison of wind project guidelines developed by the U.S. Fish and Wildlife Service (USFWS) in May 2003 and the Washington State Department of Fish and Wildlife in August 2003. Questions addressed included: is there a need or desire for uniform national or state criteria; can other states learn from Washington State's example, or from the USFWS voluntary guidelines; should there be uniform requirements/guidelines/check-lists for the siting, operation, monitoring, and mitigation to prevent or minimize avian, bat, and other wildlife impacts.

  17. Accelerated Application Development: The ORNL Titan Experience

    DOE PAGES

    Joubert, Wayne; Archibald, Richard K.; Berrill, Mark A.; ...

    2015-05-09

    The use of computational accelerators such as NVIDIA GPUs and Intel Xeon Phi processors is now widespread in the high performance computing community, with many applications delivering impressive performance gains. However, programming these systems for high performance, performance portability and software maintainability has been a challenge. In this paper we discuss experiences porting applications to the Titan system. Titan, which began planning in 2009 and was deployed for general use in 2013, was the first multi-petaflop system based on accelerator hardware. To ready applications for accelerated computing, a preparedness effort was undertaken prior to delivery of Titan. In this papermore » we report experiences and lessons learned from this process and describe how users are currently making use of computational accelerators on Titan.« less

  18. Accelerated Application Development: The ORNL Titan Experience

    SciTech Connect

    Joubert, Wayne; Archibald, Richard K.; Berrill, Mark A.; Brown, W. Michael; Eisenbach, Markus; Grout, Ray; Larkin, Jeff; Levesque, John; Messer, Bronson; Norman, Matthew R.; Philip, Bobby; Sankaran, Ramanan; Tharrington, Arnold N.; Turner, John A.

    2015-05-09

    The use of computational accelerators such as NVIDIA GPUs and Intel Xeon Phi processors is now widespread in the high performance computing community, with many applications delivering impressive performance gains. However, programming these systems for high performance, performance portability and software maintainability has been a challenge. In this paper we discuss experiences porting applications to the Titan system. Titan, which began planning in 2009 and was deployed for general use in 2013, was the first multi-petaflop system based on accelerator hardware. To ready applications for accelerated computing, a preparedness effort was undertaken prior to delivery of Titan. In this paper we report experiences and lessons learned from this process and describe how users are currently making use of computational accelerators on Titan.

  19. Development and Validation of the Documentation of Occupational Therapy Session during Intervention (D.O.T.S.I.)

    ERIC Educational Resources Information Center

    Bart, O.; Avrech Bar, M.; Rosenberg, L.; Hamudot, V.; Jarus, T.

    2011-01-01

    Objective: To develop and validate a form for Documentation of Occupational Therapy Session during Intervention (D.O.T.S.I) based on the OTPF. This form may fill the need for more consistent and detailed documentation of the intervention process. Method: Fifty five pediatric OT's documented 2-3 treatment sessions. A total of 120 treatment sessions…

  20. Accelerator mass spectrometry at the Australian National University's 14UD accelerator: experience and developments

    NASA Astrophysics Data System (ADS)

    Fifield, L. K.; Ophel, T. R.; Allan, G. L.; Bird, J. R.; Davie, R. F.

    1990-12-01

    Although the major emphasis of the joint ANU/ANSTO accelerator mass spectrometry program has been the measurement of 36Cl samples, both 14C and 10Be capabilities have been implemented recently on the 14UD accelerator. The new developments and operating experience are reviewed.

  1. Technology development for high power induction accelerators

    SciTech Connect

    Birx, D.L.; Reginato, L.L.

    1985-06-11

    The marriage of Induction Linac technology with Nonlinear Magnetic Modulators has produced some unique capabilities. It appears possible to produce electron beams with average currents measured in amperes, at gradients exceeding 1 MeV/meter, and with power efficiencies approaching 50%. A 2 MeV, 5 kA electron accelerator has been constructed at the Lawrence Livermore National Laboratory (LLNL) to demonstrate these concepts and to provide a test facility for high brightness sources. The pulse drive for the accelerator is based on state-of-the-art magnetic pulse compressors with very high peak power capability, repetition rates exceeding a kilohertz and excellent reliability.

  2. Poster Session

    NASA Technical Reports Server (NTRS)

    1997-01-01

    In this session, Poster Session, the discussion focuses on the following topics: Development of correlative measures for the assessment of attention and memory; Biodynamical Responses of the Crewmember Head/Neck System During Emergence Ejection; Fecundation in the Sky, a Ten Years Old Experiment in Microgravity; A Modified Botex Incubator as a Transport System For Developing Crickets into Space; Chromosomal Aberrations in Peripheral Lymphocytes of Cosmonauts and Astronauts after Space Flights; Method for Establishing Long term Bone Marrow; Cultures Under Microgravity Conditions Reproduction Under Simulated Weightlessness --Mammalian in vivo Experiments Under Suspension; Towards Human Movement Analysis Without the Use of Markers; Habitability Requirements For a Cogent Mars Mission; The Saucer Concept for Space Habitats; New Way In Modeling the Growth of the Organism; The Fractionation of Hydrogen and Oxygen Stable Isotopes By Life Support Systems of Space Station "MIR"; and Effect of Space Flight on Neutrophil Function.

  3. Feedback in Flow for Accelerated Reaction Development.

    PubMed

    Reizman, Brandon J; Jensen, Klavs F

    2016-09-20

    The pharmaceutical industry is investing in continuous flow and high-throughput experimentation as tools for rapid process development accelerated scale-up. Coupled with automation, these technologies offer the potential for comprehensive reaction characterization and optimization, but with the cost of conducting exhaustive multifactor screens. Automated feedback in flow offers researchers an alternative strategy for efficient characterization of reactions based on the use of continuous technology to control chemical reaction conditions and optimize in lieu of screening. Optimization with feedback allows experiments to be conducted where the most information can be gained from the chemistry, enabling product yields to be maximized and kinetic models to be generated while the total number of experiments is minimized. This Account opens by reviewing select examples of feedback optimization in flow and applications to chemical research. Systems in the literature are classified into (i) deterministic "black box" optimization systems that do not model the reaction system and are therefore limited in the utility of results for scale-up, (ii) deterministic model-based optimization systems from which reaction kinetics and/or mechanisms can be automatically evaluated, and (iii) stochastic systems. Though diverse in application, flow feedback systems have predominantly focused upon the optimization of continuous variables, i.e., variables such as time, temperature, and concentration that can be ramped from one experiment to the next. Unfortunately, this implies that the screening of discrete variables such as catalyst, ligand, or solvent generally does not factor into automated flow optimization, resulting in incomplete process knowledge. Herein, we present a system and strategy developed for optimizing discrete and continuous variables of a chemical reaction simultaneously. The approach couples automated feedback with high-throughput reaction screening in droplet flow

  4. Creating psychological connections between intervention recipients: development and focus group evaluation of a group singing session for people with aphasia

    PubMed Central

    Tarrant, Mark; Warmoth, Krystal; Code, Chris; Dean, Sarah; Goodwin, Victoria A; Stein, Ken; Sugavanam, Thavapriya

    2016-01-01

    Objectives The study sought to identify key design features that could be used to create a new framework for group-based health interventions. We designed and tested the first session of a group intervention for stroke survivors with aphasia which was aimed at nurturing new psychological connections between group members. Setting The intervention session, a participant focus group and interviews with intervention facilitators were held in a local community music centre in the South West of England. Participants A convenience sample of 10 community-dwelling people with poststroke aphasia participated in the session. Severity of aphasia was not considered for inclusion. Intervention Participants took part in a 90-min group singing session which involved singing songs from a specially prepared song book. Musical accompaniment was provided by the facilitators. Primary and secondary outcome measures Participants and group facilitators reported their experiences of participating in the session, with a focus on activities within the session related to the intervention aims. Researcher observations of the session were also made. Results Two themes emerged from the analysis, concerning experiences of the session (‘developing a sense of group belonging’) and perceptions of its design and delivery (‘creating the conditions for engagement’). Participants described an emerging sense of shared social identity as a member of the intervention group and identified fixed (eg, group size, session breaks) and flexible (eg, facilitator responsiveness) features of the session which contributed to this emergence. Facilitator interviews and researcher observations corroborated and expanded participant reports. Conclusions Engagement with health intervention content may be enhanced in group settings when intervention participants begin to establish positive and meaningful psychological connections with other group members. Understanding and actively nurturing these connections

  5. Vacuum Insulator Development for the Dielectric Wall Accelerator

    SciTech Connect

    Harris, J R; Blackfield, D; Caporaso, G J; Chen, Y; Hawkins, S; Kendig, M; Poole, B; Sanders, D M; Krogh, M; Managan, J E

    2008-03-17

    At Lawrence Livermore National Laboratory, we are developing a new type of accelerator, known as a Dielectric Wall Accelerator, in which compact pulse forming lines directly apply an accelerating field to the beam through an insulating vacuum boundary. The electrical strength of this insulator may define the maximum gradient achievable in these machines. To increase the system gradient, we are using 'High Gradient Insulators' composed of alternating layers of dielectric and metal for the vacuum insulator. In this paper, we present our recent results from experiment and simulation, including the first test of a High Gradient Insulator in a functioning Dielectric Wall Accelerator cell.

  6. Miniature penetrator (MinPen) acceleration recorder development test

    SciTech Connect

    Franco, R.J.; Platzbecker, M.R.

    1998-08-01

    The Telemetry Technology Development Department at Sandia National Laboratories actively develops and tests acceleration recorders for penetrating weapons. This new acceleration recorder (MinPen) utilizes a microprocessor-based architecture for operational flexibility while maintaining electronics and packaging techniques developed over years of penetrator testing. MinPen has been demonstrated to function in shock environments up to 20,000 Gs. The MinPen instrumentation development has resulted in a rugged, versatile, miniature acceleration recorder and is a valuable tool for penetrator testing in a wide range of applications.

  7. Accelerator and rf system development for NLC

    SciTech Connect

    Vlieks, A.E.; Callin, R.; Deruyter, H.

    1993-04-01

    An experimental station for an X-band Next Linear Collider has been constructed at SLAC. This station consists of a klystron and modulator, a low-loss waveguide system for rf power distribution, a SLED II pulse-compression and peak-power multiplication system, acceleration sections and beam-line components (gun, prebuncher, preaccelerator, focussing elements and spectrometer). An extensive program of experiments to evaluate the performance of all components is underway. The station is described in detail in this paper, and results to date are presented.

  8. Advanced Microgravity Acceleration Measurement Systems (AMAMS) Being Developed

    NASA Technical Reports Server (NTRS)

    Sicker, Ronald J.; Kacpura, Thomas J.

    2003-01-01

    The Advanced Microgravity Acceleration Measurement Systems (AMAMS) project is part of NASA s Instrument Technology Development program to develop advanced sensor systems. The primary focus of the AMAMS project is to develop microelectromechanical systems (MEMS) for acceleration sensor systems to replace existing electromechanical sensor systems presently used to assess relative gravity levels aboard spacecraft. These systems are used to characterize both vehicle and payload responses to low-gravity vibroacoustic environments. The collection of microgravity acceleration data is useful to the microgravity life sciences, microgravity physical sciences, and structural dynamics communities. The inherent advantages of semiconductor-based systems are reduced size, mass, and power consumption, with enhanced long-term calibration stability.

  9. Development of compact linear accelerator in KBSI

    SciTech Connect

    Yoon, Jang-Hee; Lee, Byoung-Seob; Choi, Seyong; Park, Jin Yong; Ok, Jung-Woo; Won, Mi-Sook

    2012-02-15

    The compact linear accelerator using a 28 GHz ECRIS is under construction in KBSI, South Korea. The main capability of this facility is the production of fast neurons for the neutron radiography. The designing of a superconducting magnet, microwave transmission system, beam extraction, and plasma chamber of ECRIS were finished. The nominal axial design fields of the magnets are 3.6 T at injection and 2.2 T at extraction; the nominal radial design field strength at the plasma chamber wall is 2.1 T. We already installed 10 kW, 28 GHz gyrotron, and tested a microwave power from gyrotron using a dummy load. The current status will be discussed in this paper.

  10. Development of compact linear accelerator in KBSI.

    PubMed

    Yoon, Jang-Hee; Lee, Byoung-Seob; Choi, Seyong; Park, Jin Yong; Ok, Jung-Woo; Won, Mi-Sook

    2012-02-01

    The compact linear accelerator using a 28 GHz ECRIS is under construction in KBSI, South Korea. The main capability of this facility is the production of fast neurons for the neutron radiography. The designing of a superconducting magnet, microwave transmission system, beam extraction, and plasma chamber of ECRIS were finished. The nominal axial design fields of the magnets are 3.6 T at injection and 2.2 T at extraction; the nominal radial design field strength at the plasma chamber wall is 2.1 T. We already installed 10 kW, 28 GHz gyrotron, and tested a microwave power from gyrotron using a dummy load. The current status will be discussed in this paper.

  11. Development of compact linear accelerator in KBSIa)

    NASA Astrophysics Data System (ADS)

    Yoon, Jang-Hee; Lee, Byoung-Seob; Choi, Seyong; Park, Jin Yong; Ok, Jung-Woo; Won, Mi-Sook

    2012-02-01

    The compact linear accelerator using a 28 GHz ECRIS is under construction in KBSI, South Korea. The main capability of this facility is the production of fast neurons for the neutron radiography. The designing of a superconducting magnet, microwave transmission system, beam extraction, and plasma chamber of ECRIS were finished. The nominal axial design fields of the magnets are 3.6 T at injection and 2.2 T at extraction; the nominal radial design field strength at the plasma chamber wall is 2.1 T. We already installed 10 kW, 28 GHz gyrotron, and tested a microwave power from gyrotron using a dummy load. The current status will be discussed in this paper.

  12. Learning Disabilities in the Workplace: A Professional Development Packet. Session 1 & 2.

    ERIC Educational Resources Information Center

    Corley, Mary Ann; Tibbetts, John

    This field-tested training packet, which was designed for adult literacy providers, contains preparation materials, facilitator's notes, handout masters, and transparency masters for two 3-hour sessions on learning disabilities (LD) in the workplace. (At the end of the first session supported by the packet, participants will be able to do the…

  13. 76 FR 33305 - Medicare Program; Accelerated Development Sessions for Accountable Care Organizations-June 20, 21...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-08

    ... ``central daylight time''. (4) In the ADDRESSES section, line 2, the acronym ``ADS'' is corrected to read..., the acronym ``ADSs'' is corrected to read ``ADLSs''. (d) Line 21, the phrase ``quality outcomes'' is corrected to read ``outcomes''. (2) Last paragraph, line 1, the acronym ``ADS'' is corrected to read...

  14. 76 FR 50224 - Medicare Program; Accountable Care Organization Accelerated Development Learning Sessions; Center...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-12

    ... register a team of senior executives to attend the in-person ADLS. The ADLS will provide executives with the opportunity to learn about core functions of an ACO and ways to build their organization's... intended to provide ACOs with the opportunity to learn from their peers about essential ACO functions...

  15. 76 FR 66931 - Medicare Program; Accountable Care Organization Accelerated Development Learning Sessions; Center...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-28

    ... register a team of senior executives to attend the in- person ADLS. The ADLS will provide executives with the opportunity to learn about core functions of an ACO and ways to build their organization's... provide ACOs with the opportunity to learn from their peers about essential ACO functions and various...

  16. Computational Tools for Accelerating Carbon Capture Process Development

    SciTech Connect

    Miller, David; Sahinidis, N V; Cozad, A; Lee, A; Kim, H; Morinelly, J; Eslick, J; Yuan, Z

    2013-06-04

    This presentation reports development of advanced computational tools to accelerate next generation technology development. These tools are to develop an optimized process using rigorous models. They include: Process Models; Simulation-Based Optimization; Optimized Process; Uncertainty Quantification; Algebraic Surrogate Models; and Superstructure Optimization (Determine Configuration).

  17. Within- and between-session reliability of power, force, and rate of force development during the power clean.

    PubMed

    Comfort, Paul

    2013-05-01

    Although there has been extensive research regarding the power clean, its application to sports performance, and use as a measure of assessing changes in performance, no research has determined the reliability assessing the kinetics of the power clean across testing session. The aim of this study was to determine the within- and between-session reliability of kinetic variables during the power clean. Twelve professional rugby league players (age 24.5 ± 2.1 years; height 182.86 ± 6.97 cm; body mass 92.85 ± 5.67 kg; 1 repetition maximum [1RM] power clean 102.50 ± 10.35 kg) performed 3 sets of 3 repetitions of power cleans at 70% of their 1RM, while standing on a force plate, to determine within-session reliability and repeated on 3 separate occasions to determine reliability between sessions. Intraclass correlation coefficients revealed a high reliability within- (r ≥ 0.969) and between-sessions (r ≥ 0.988). Repeated-measures analysis of variance showed no significant difference (p > 0.05) in peak vertical ground reaction force, rate of force development, and peak power between sessions, with small standard error of the measurements and smallest detectable differences for each kinetic variable (3.13 and 8.68 N; 84.39 and 233.93 N·s; 24.54 and 68.01 W, respectively). Therefore, to identify a meaningful change in performance, the strength and conditioning coach should look for a change in peak force ≥8.68 N, rate of force development ≥24.54 N·s, and a change in peak power ≥68.01 W to signify an adaptive response to training, which is greater than the variance between sessions, in trained athletes proficient at performing the power clean.

  18. IFLA General Conference, 1986. Pre-Session Seminar on Special Libraries and Their Role in National Development. Papers.

    ERIC Educational Resources Information Center

    International Federation of Library Associations and Institutions, The Hague (Netherlands).

    A seminar on special libraries and their role in national development was held as a pre-session before the IFLA conference in 1986. Papers presented include: (1) "On the Problem of Document Delivery in the Field of Science and Technology in Asia" (Daxun He, People's Republic of China); (2) "The Planning and Development of Special…

  19. Stacked subsea templates accelerate deepwater development

    SciTech Connect

    Ramsey, J.F.; Blincow, R.M.; Pickard, R.D. )

    1991-10-21

    This paper reports on a deepwater project that can be brought on-line more quickly because of stackable drilling and production templates. Historically, one of the primary barriers to the economic development of deepwater reserves has been the long lead time from discovery to first production. Typically, production facilities must be built and often installed before development wells are drilled. The use of three-slot drilling templates allows development drilling to proceed while the production templates, Christmas trees, flow lines, and production platform are constructed. Thus, the time from initial investment to first revenue reduced. Enserch Exploration Inc., along with partners Petrofina Delaware Inc. and AGIP Petroleum, is using a piggy-back or transportable stacked template system to develop deepwater gas reserves in Mississippi Canyon Block 441, approximately 50 miles south of Grand Isle, La. The discovery is located in 1,410-1,520 ft of water. The Louisiana Offshore Oil Port (LOOP) safety fairway running north to south covers the eastern three fourths of Mississippi Canyon Block 441 and rules out surface production facilities over the well locations.

  20. Computational Tools to Accelerate Commercial Development

    SciTech Connect

    Miller, David C

    2013-01-01

    The goals of the work reported are: to develop new computational tools and models to enable industry to more rapidly develop and deploy new advanced energy technologies; to demonstrate the capabilities of the CCSI Toolset on non-proprietary case studies; and to deploy the CCSI Toolset to industry. Challenges of simulating carbon capture (and other) processes include: dealing with multiple scales (particle, device, and whole process scales); integration across scales; verification, validation, and uncertainty; and decision support. The tools cover: risk analysis and decision making; validated, high-fidelity CFD; high-resolution filtered sub-models; process design and optimization tools; advanced process control and dynamics; process models; basic data sub-models; and cross-cutting integration tools.

  1. Status of high temperature superconductor development for accelerator magnets

    NASA Technical Reports Server (NTRS)

    Hirabayashi, H.

    1995-01-01

    High temperature superconductors are still under development for various applications. As far as conductors for magnets are concerned, the development has just been started. Small coils wound by silver sheathed Bi-2212 and Bi-2223 oxide conductors have been reported by a few authors. Essential properties of high T(sub c) superconductors like pinning force, coherent length, intergrain coupling, weak link, thermal property, AC loss and mechanical strength are still not sufficiently understandable. In this talk, a review is given with comparison between the present achievement and the final requirement for high T(sub c) superconductors, which could be particularly used in accelerator magnets. Discussions on how to develop high T(sub c) superconductors for accelerator magnets are included with key parameters of essential properties. A proposal of how to make a prototype accelerator magnet with high T(sub c) superconductors with prospect for future development is also given.

  2. Accelerated larvae development of Ascaris lumbricoides eggs with ultraviolet radiation

    NASA Astrophysics Data System (ADS)

    Aladawi, M. A.; Albarodi, H.; Hammoudeh, A.; Shamma, M.; Sharabi, N.

    2006-01-01

    In order to investigate the effect of UV radiation on the development of Ascaris lumbricoides larvae, eggs were exposed to increasing UV doses. Filtered wastewater from the secondary effluent taken from the Damascus wastewater treatment plant (DWTP) was used as irradiation and incubation medium. The progressive and accelerated embryonation stages were microscopically observed and the percentages of completely developed larvae were determined weekly. Results indicated that the UV radiation accelerated the development of larvae with increasing UV dose. Preliminary information about the relationship between the UV radiation dose and rate of embryonation is also presented.

  3. Space Launch System Accelerated Booster Development Cycle

    NASA Technical Reports Server (NTRS)

    Arockiam, Nicole; Whittecar, William; Edwards, Stephen

    2012-01-01

    With the retirement of the Space Shuttle, NASA is seeking to reinvigorate the national space program and recapture the public s interest in human space exploration by developing missions to the Moon, near-earth asteroids, Lagrange points, Mars, and beyond. The would-be successor to the Space Shuttle, NASA s Constellation Program, planned to take humans back to the Moon by 2020, but due to budgetary constraints was cancelled in 2010 in search of a more "affordable, sustainable, and realistic" concept2. Following a number of studies, the much anticipated Space Launch System (SLS) was unveiled in September of 2011. The SLS core architecture consists of a cryogenic first stage with five Space Shuttle Main Engines (SSMEs), and a cryogenic second stage using a new J-2X engine3. The baseline configuration employs two 5-segment solid rocket boosters to achieve a 70 metric ton payload capability, but a new, more capable booster system will be required to attain the goal of 130 metric tons to orbit. To this end, NASA s Marshall Space Flight Center recently released a NASA Research Announcement (NRA) entitled "Space Launch System (SLS) Advanced Booster Engineering Demonstration and/or Risk Reduction." The increased emphasis on affordability is evident in the language used in the NRA, which is focused on risk reduction "leading to an affordable Advanced Booster that meets the evolved capabilities of SLS" and "enabling competition" to "enhance SLS affordability. The purpose of the work presented in this paper is to perform an independent assessment of the elements that make up an affordable and realistic path forward for the SLS booster system, utilizing advanced design methods and technology evaluation techniques. The goal is to identify elements that will enable a more sustainable development program by exploring the trade space of heavy lift booster systems and focusing on affordability, operability, and reliability at the system and subsystem levels5. For this study

  4. An accelerated fusion power development plan

    NASA Astrophysics Data System (ADS)

    Dean, Stephen O.; Baker, Charles C.; Cohn, Daniel R.; Kinkead, Susan D.

    1991-06-01

    Energy for electricity and transportation is a national issue with worldwide environmental and political implications. The world must have energy options for the next century that are not vulnerable to possible disruption for technical, environmental, public confidence, or other reasons. Growing concerns about the greenhouse effect and the safety of transporting oil may lead to reduced burning of coal and other fossil fuels, and the incidents at Three Mile Island and Chernobyl, as well as nuclear waste storage problems, have eroded public acceptance of nuclear fission. Meeting future world energy needs will require improvements in energy efficiency and conservation. However, the world will soon need new central station power plants and increasing amounts of fuel for the transportation sector. The use of fossil fuels, and possibly even fission power, will very likely be restricted because of environmental, safety, and, eventually, supply considerations. Time is running out for policymakers. New energy technologies cannot be brought to the marketplace overnight. Decades are required to bring a new energy production technology from conception to full market penetration. With the added urgency to mitigate deleterious environmental effects of energy use, policymakers must act decisively now to establish and support vigorous energy technology development programs. The U.S. has invested 8 billion over the past 40 years in fusion research and development. If the U.S. fusion program proceeds according to its present strategy, an additional 40 years, and more money, will be expended before fusion will provide commercial electricity. Such an extended schedule is neither cost-effective nor technically necessary. It is time to launch a national venture to construct and operate a fusion power pilot plant. Such a plant could be operational within 15 years of a national commitment to proceed.

  5. Accelerating Leadership Development via Immersive Learning and Cognitive Apprenticeship

    ERIC Educational Resources Information Center

    Backus, Clark; Keegan, Kevin; Gluck, Charles; Gulick, Lisa M. V.

    2010-01-01

    The authors put forward an approach to leadership development that builds on the principle of accelerated learning. They argue that leadership development, particularly in a period of recession or slow economic growth, needs to deliver results more quickly and with fewer resources. Indeed, they raise the question of whether or not this is what is…

  6. No Time To Kill: Entrainment and Accelerating Courseware Development.

    ERIC Educational Resources Information Center

    Millington, Paula Crnkovich

    This paper examines the concept of time in multimedia, World Wide Web-based courseware development. The biological concept of entrainment (the alignment of rhythms within and between systems) to accelerate courseware development is explored. The discussion begins with the foundational concepts of entrainment from biological systems and social…

  7. Session: Bat ecology related to wind development and lessons learned about impacts on bats from wind development

    SciTech Connect

    Johnson, Greg; Kunz, Thomas

    2004-09-01

    This session at the Wind Energy and Birds/Bats workshop consisted of two paper presentations followed by a discussion/question and answer period. It was the first of the sessions to shift the focus to the issue of wind energy development's impacts specifically to bats. The presentations discussed lessons that have been learned regarding direct and indirect impacts on bats and strategies planned to address such issues. Presenters addressed what the existing science demonstrates about land-based wind turbine impacts on bats, including: mortality, avoidance, direct habitat impacts, species and numbers killed, per turbine rates/per MW generated, and impacts on threatened and endangered species. They discussed whether there is sufficient data for wind turbines and bat impacts for projects in the eastern US, especially on ridge tops. Finally, the subject of offshore impacts on bats was briefly addressed, including what lessons have been learned in Europe and how these can be applied in the U S. Paper one, by Greg Johnson, was titled ''A Review of Bat Impacts at Wind Farms in the US''. Paper two, by Thomas Kunz, was titled ''Wind Power: Bats and Wind Turbines''.

  8. Development of wide area environment accelerator operation and diagnostics method

    NASA Astrophysics Data System (ADS)

    Uchiyama, Akito; Furukawa, Kazuro

    2015-08-01

    Remote operation and diagnostic systems for particle accelerators have been developed for beam operation and maintenance in various situations. Even though fully remote experiments are not necessary, the remote diagnosis and maintenance of the accelerator is required. Considering remote-operation operator interfaces (OPIs), the use of standard protocols such as the hypertext transfer protocol (HTTP) is advantageous, because system-dependent protocols are unnecessary between the remote client and the on-site server. Here, we have developed a client system based on WebSocket, which is a new protocol provided by the Internet Engineering Task Force for Web-based systems, as a next-generation Web-based OPI using the Experimental Physics and Industrial Control System Channel Access protocol. As a result of this implementation, WebSocket-based client systems have become available for remote operation. Also, as regards practical application, the remote operation of an accelerator via a wide area network (WAN) faces a number of challenges, e.g., the accelerator has both experimental device and radiation generator characteristics. Any error in remote control system operation could result in an immediate breakdown. Therefore, we propose the implementation of an operator intervention system for remote accelerator diagnostics and support that can obviate any differences between the local control room and remote locations. Here, remote-operation Web-based OPIs, which resolve security issues, are developed.

  9. Enhancing Tutorial Learning Experiences: A Programme to Develop Sessional-Tutor Teaching Skills by Raising Awareness about Learning

    ERIC Educational Resources Information Center

    Truuvert, Toomas

    2014-01-01

    This article outlines the trial of a programme to enhance tutorial learning experiences by raising sessional-tutor awareness about learning, and reflects on its results. The author developed the programme for an introductory undergraduate unit in finance with historically very large enrolments, diverse student populations, and high failure rates.…

  10. DEVELOPMENT OF A COMPACT RADIOGRAPHY ACCELERATOR USING DIELECTRIC WALL ACCELERATOR TECHNOLOGY

    SciTech Connect

    Sampayan, S; Caporaso, G; Chen, Y; Hawkins, S; Holmes, C; Krogh, M; McCarrick, J; Nelson, S; Nunnally, W; Poole, B; Rhodes, M; Sanders, D; Selenes, K; Sullivan, J; Wang, L; Watson, J

    2005-06-02

    We are developing an inexpensive compact accelerator system primarily intended for pulsed radiography. Design characteristics are an 8 MeV endpoint energy, 2 kA beam current, a cell gradient of approximately 3 MV/m (for an overall accelerator length is 2-3 m), and <$1/Volt capital costs. Such designs have been made possible with the development of high specific energy dielectrics (>10J/cm{sup 3}), specialized transmission line designs and multi-gap laser triggered low jitter (<1 ns) gas switches. In this geometry, the pulse forming lines, switches, and insulator/beam pipe are fully integrated within each cell to form a compact, stand-alone, stackable unit. We detail our research and modeling to date, recent high voltage test results, and the integration concept of the cells into a radiographic system.

  11. Session: Non-fatality and habitat impacts on birds from wind energy development

    SciTech Connect

    Strickland, Dale

    2004-09-01

    This session at the Wind Energy and Birds/Bats workshop was consisted of one paper presentation followed by a discussion/question and answer period. The session focused on discussion of non-collision impacts of wind energy projects on birds, primarily impacts to habitat. The presentation included information about the impacts of habitat fragmentation, disturbance, and site avoidance from wind turbines, as well as from roads, transmission facilities, and other related construction at wind project sites. Whether birds habituate to the presence of turbines and the influence of regional factors were also addressed. The paper given by Dale Strickland was titled ''Overview of Non-Collision Related Impacts from Wind Projects''.

  12. Session: Why avian impacts are a concern in wind energy development

    SciTech Connect

    Winegrad, Gerald

    2004-09-01

    This lunchtime session at the Wind Energy and Birds/Bats workshop consisted of one presentation followed by a discussion/question and answer period. The session provided a more detailed overview of the environmental community's perspective on wind power's impacts on birds. The presentation described how wind projects impact birds, detailing the species distribution of collisions at various sites around the US and discussing problems such as avoidance, habitat disturbance, and cumulative effects on populations. The presentation, ''Wind Turbines and Birds'', was given by Gerald Winegrad from the American Bird Conservancy.

  13. Accelerating Child Survival and Development in Dark Times.

    ERIC Educational Resources Information Center

    Grant, James P.

    Measures were proposed that would enable UNICEF, in association with others and despite prevailing difficult economic circumstances, to more effectively bring well-being and hope to hundreds of millions of children. Specific proposals were designed to help most countries accelerate child survival and development. Most particularly, it was…

  14. Accelerating Early Language Development with Multi-Sensory Training

    ERIC Educational Resources Information Center

    Bjorn, Piia M.; Kakkuri, Irma; Karvonen, Pirkko; Leppanen, Paavo H. T.

    2012-01-01

    This paper reports the outcome of a multi-sensory intervention on infant language skills. A programme titled "Rhyming Game and Exercise Club", which included kinaesthetic-tactile mother-child rhyming games performed in natural joint attention situations, was intended to accelerate Finnish six- to eight-month-old infants' language development. The…

  15. Development of a Wireless Displacement Measurement System Using Acceleration Responses

    PubMed Central

    Park, Jong-Woong; Sim, Sung-Han; Jung, Hyung-Jo; Spencer, Billie F.

    2013-01-01

    Displacement measurements are useful information for various engineering applications such as structural health monitoring (SHM), earthquake engineering and system identification. Most existing displacement measurement methods are costly, labor-intensive, and have difficulties particularly when applying to full-scale civil structures because the methods require stationary reference points. Indirect estimation methods converting acceleration to displacement can be a good alternative as acceleration transducers are generally cost-effective, easy to install, and have low noise. However, the application of acceleration-based methods to full-scale civil structures such as long span bridges is challenging due to the need to install cables to connect the sensors to a base station. This article proposes a low-cost wireless displacement measurement system using acceleration. Developed with smart sensors that are low-cost, wireless, and capable of on-board computation, the wireless displacement measurement system has significant potential to impact many applications that need displacement information at multiple locations of a structure. The system implements an FIR-filter type displacement estimation algorithm that can remove low frequency drifts typically caused by numerical integration of discrete acceleration signals. To verify the accuracy and feasibility of the proposed system, laboratory tests are carried out using a shaking table and on a three storey shear building model, experimentally confirming the effectiveness of the proposed system. PMID:23881123

  16. Development of a fast voltage control method for electrostatic accelerators

    NASA Astrophysics Data System (ADS)

    Lobanov, Nikolai R.; Linardakis, Peter; Tsifakis, Dimitrios

    2014-12-01

    The concept of a novel fast voltage control loop for tandem electrostatic accelerators is described. This control loop utilises high-frequency components of the ion beam current intercepted by the image slits to generate a correction voltage that is applied to the first few gaps of the low- and high-energy acceleration tubes adjoining the high voltage terminal. New techniques for the direct measurement of the transfer function of an ultra-high impedance structure, such as an electrostatic accelerator, have been developed. For the first time, the transfer function for the fast feedback loop has been measured directly. Slow voltage variations are stabilised with common corona control loop and the relationship between transfer functions for the slow and new fast control loops required for optimum operation is discussed. The main source of terminal voltage instabilities, which are due to variation of the charging current caused by mechanical oscillations of charging chains, has been analysed.

  17. Biofuels and Sustainable Development: An Executive Session on the Grand Challenges of the Sustainability Transition

    SciTech Connect

    Lee, Henry; Clark, William C.; Devereaux, Charan

    2008-05-20

    This report is the result of the second in a series of intense workshops and study sessions on Grand Challenges of the Sustainability Transition, organized by the Sustainability Science Program at Harvard University, hosted by Venice International University, and supported by the Italian Ministry of Environment, Land and Sea.

  18. Accelerating clinical insights: how to use accelerator mass spectrometry to make better early development decisions.

    PubMed

    Seymour, Mark

    2010-12-01

    This paper is an overview of the applications of the technique of Accelerator Mass Spectrometry (AMS) in the biomedical drug development field. The work described here has been carried out at Xceleron (York, UK and Germantown, MD, USA), and it aims to apply AMS to provide better information about the human pharmacokinetic/metabolic behaviour of drugs or drug candidates as early as possible. It is hoped that the use of this technique will contribute to the delivery of better, more effective drugs onto the market sooner, which will be good news for all concerned.

  19. Session: Avian migration and implications for wind power development in the Eastern United States

    SciTech Connect

    Mabey, Sarah; Cooper, Brian

    2004-09-01

    This session at the Wind Energy and Birds/Bats workshop consisted of two presentations followed by a discussion/question and answer period. The session was arranged to convey what is known about avian migration, particularly in the eastern US. The first presentation ''Migration Ecology: Issues of Scale and Behavior'' by Sarah Mabey frames the issue of migratory bird interactions with wind energy facilities from an ecological perspective: when, where, and why are migrant bird species vulnerable to wind turbine collision. The second presentation ''Radar Studies of Nocturnal Migration at Wind Sites in the Eastern US'' by Brian Cooper reported on radar studies conducted at wind sites in the eastern US, including Mount Storm, Clipper Wind, and others.

  20. Accelerating Vaccine Formulation Development Using Design of Experiment Stability Studies.

    PubMed

    Ahl, Patrick L; Mensch, Christopher; Hu, Binghua; Pixley, Heidi; Zhang, Lan; Dieter, Lance; Russell, Ryann; Smith, William J; Przysiecki, Craig; Kosinski, Mike; Blue, Jeffrey T

    2016-10-01

    Vaccine drug product thermal stability often depends on formulation input factors and how they interact. Scientific understanding and professional experience typically allows vaccine formulators to accurately predict the thermal stability output based on formulation input factors such as pH, ionic strength, and excipients. Thermal stability predictions, however, are not enough for regulators. Stability claims must be supported by experimental data. The Quality by Design approach of Design of Experiment (DoE) is well suited to describe formulation outputs such as thermal stability in terms of formulation input factors. A DoE approach particularly at elevated temperatures that induce accelerated degradation can provide empirical understanding of how vaccine formulation input factors and interactions affect vaccine stability output performance. This is possible even when clear scientific understanding of particular formulation stability mechanisms are lacking. A DoE approach was used in an accelerated 37(°)C stability study of an aluminum adjuvant Neisseria meningitidis serogroup B vaccine. Formulation stability differences were identified after only 15 days into the study. We believe this study demonstrates the power of combining DoE methodology with accelerated stress stability studies to accelerate and improve vaccine formulation development programs particularly during the preformulation stage.

  1. Advances in Parallel Electromagnetic Codes for Accelerator Science and Development

    SciTech Connect

    Ko, Kwok; Candel, Arno; Ge, Lixin; Kabel, Andreas; Lee, Rich; Li, Zenghai; Ng, Cho; Rawat, Vineet; Schussman, Greg; Xiao, Liling; /SLAC

    2011-02-07

    Over a decade of concerted effort in code development for accelerator applications has resulted in a new set of electromagnetic codes which are based on higher-order finite elements for superior geometry fidelity and better solution accuracy. SLAC's ACE3P code suite is designed to harness the power of massively parallel computers to tackle large complex problems with the increased memory and solve them at greater speed. The US DOE supports the computational science R&D under the SciDAC project to improve the scalability of ACE3P, and provides the high performance computing resources needed for the applications. This paper summarizes the advances in the ACE3P set of codes, explains the capabilities of the modules, and presents results from selected applications covering a range of problems in accelerator science and development important to the Office of Science.

  2. Impact of accelerated plant growth on seed variety development

    NASA Astrophysics Data System (ADS)

    Christophersen, Eric

    1998-01-01

    The commercial lives of agricultural seed products have steadily declined in recent years. The introduction of genetically engineered crop seeds in 1966 has accentuated that trend. Widespread grower demand for genetically engineered seed requires competitive response by industry followers in order to avert market share losses to the industry leaders. Limitations on plant transformation technology, regulatory requirements and patent impediments require companies to rapidly convert transformed lines into elite commercial products. Massive multigenerational backcrossing efforts are required to distribute genetically engineered traits into a broad product mix. Significant incidents of expression failures, or ``gene silencing,'' have occurred unexpectedly, requiring product substitution strategies. First-to-market strategies, competitive response, broad germplasm conversion and rescue of product failures all share the element of urgency. Technologies which reliably accelerate product development rates can expect favorable reception by commercial seed developers. A growth chamber which dramatically accelerates the rate of plant growth is described.

  3. Development of X-Band Dielectric-Loaded Accelerating Structures

    SciTech Connect

    Gold, S. H.; Jing, C.; Kanareykin, A.; Gai, W.; Konecny, R.; Power, J. G.; Kinkead, A. K.

    2010-11-04

    This paper presents a progress report on the development and testing of X-band dielectric-loaded accelerating structures. Recent tests on several quartz DLA structures with different inner diameters are reported. Designs for gap-free DLA structures are presented. Also, planned new experiments are discussed, including higher gradient traveling-wave and standing-wave structures and special grooved structures for multipactor suppression.

  4. Rail accelerator development for ultra-high pressure research

    SciTech Connect

    Hawke, R.S.; Nellis, W.J.; Rego, J.; Susoeff, A.R.; Newman, G.H.

    1983-09-20

    The Lawrence Livermore National Laboratory is currently developing a rail accelerator system for launching hypervelocity projectiles suitable for ultrahigh pressure shockwave research. The primary goal is to accelerate 1 g projectiles with disk impactors to velocities in excess of 12 km/s and generate uniform, planar shockwaves at pressures above 0.5 TPa (5 Mbar) in metal targets. In order to generate precisely controlled impacts and shockwaves, several strigent requirements are imposed on the railgun system. During the last year, we have begun detailed development of a railgun launcher and power source. We are developing a launcher with a gas injector. The injector accelerates the projectile to more than 1 km/s reducing the dwell time of the plasma arc and the erosion of the rails. The injected projectile, with a fuse, also serves as the main switch in the power supply circuit. Current pulse shaping is used to control the applied stress to the projectile and launcher. Results of experiments with the new system will be reported and compared to computer simulations.

  5. Rail accelerator development for ultra-high pressure research

    SciTech Connect

    Hawke, R.S.; Nellis, W.J.

    1984-03-01

    The Lawrence Livermore National Laboratory is currently developing a rail accelerator system for launching hypervelocity projectiles suitable for ultrahigh pressure shockwave research. The primary goal is to accelerate 1 g projectiles with disk impactors to velocities in excess of 12 km/s and generate uniform, planar shockwaves at pressures above 0.5 TPa (5 Mbar) in metal targets. In order to generate precisely controlled impacts and shockwaves, several stringent requirements are imposed on the railgun system. During the last year, detailed development of a railgun launcher and power source has begun. A launcher with a gas injector is being developed. The injector accelerates the projectile to more than 1 km/s reducing the dwell time of the plasma arc and the erosion of the rails. The injected projectile, with a fuse, also serves as the main switch in the power supply circuit. Current pulse shaping is used to control the applied stress to the projectile and launcher. Results of experiments with the new system are reported and compared to computer simulations.

  6. Rural Development: Report on Congressional Activities in 15 Major Categories in the 92d Congress, 1st Session. Committee Print, 92d Congress, 2d Session, February 3, 1972.

    ERIC Educational Resources Information Center

    Robbins, Frances

    This report reviews the legislative progress through December 31, 1971 of the rural development bills introduced in the U.S. Senate and House during the first session of the 92d Congress. For purposes of organization, this report presents 15 major rural development categories and limits this review to those bills and bill categories directed at…

  7. New Developments in the Simulation of Advanced Accelerator Concepts

    SciTech Connect

    Bruhwiler, David L.; Cary, John R.; Cowan, Benjamin M.; Paul, Kevin; Mullowney, Paul J.; Messmer, Peter; Geddes, Cameron G. R.; Esarey, Eric; Cormier-Michel, Estelle; Leemans, Wim; Vay, Jean-Luc

    2009-01-22

    Improved computational methods are essential to the diverse and rapidly developing field of advanced accelerator concepts. We present an overview of some computational algorithms for laser-plasma concepts and high-brightness photocathode electron sources. In particular, we discuss algorithms for reduced laser-plasma models that can be orders of magnitude faster than their higher-fidelity counterparts, as well as important on-going efforts to include relevant additional physics that has been previously neglected. As an example of the former, we present 2D laser wakefield accelerator simulations in an optimal Lorentz frame, demonstrating >10 GeV energy gain of externally injected electrons over a 2 m interaction length, showing good agreement with predictions from scaled simulations and theory, with a speedup factor of {approx}2,000 as compared to standard particle-in-cell.

  8. New Developments in the Simulation of Advanced Accelerator Concepts

    SciTech Connect

    Paul, K.; Cary, J.R.; Cowan, B.; Bruhwiler, D.L.; Geddes, C.G.R.; Mullowney, P.J.; Messmer, P.; Esarey, E.; Cormier-Michel, E.; Leemans, W.P.; Vay, J.-L.

    2008-09-10

    Improved computational methods are essential to the diverse and rapidly developing field of advanced accelerator concepts. We present an overview of some computational algorithms for laser-plasma concepts and high-brightness photocathode electron sources. In particular, we discuss algorithms for reduced laser-plasma models that can be orders of magnitude faster than their higher-fidelity counterparts, as well as important on-going efforts to include relevant additional physics that has been previously neglected. As an example of the former, we present 2D laser wakefield accelerator simulations in an optimal Lorentz frame, demonstrating>10 GeV energy gain of externally injected electrons over a 2 m interaction length, showing good agreement with predictions from scaled simulations and theory, with a speedup factor of ~;;2,000 as compared to standard particle-in-cell.

  9. Research and Development for Ultra-High Gradient Accelerator Structures

    NASA Astrophysics Data System (ADS)

    Tantawi, Sami G.; Dolgashev, Valery; Higashi, Yasuo; Spataro, Bruno

    2010-11-01

    Research on the basic physics of high-gradient, high frequency accelerator structures and the associated RF/microwave technology are essential for the future of discovery science, medicine and biology, energy and environment, and national security. We will review the state-of-the-art for the development of high gradient linear accelerators. We will present the research activities aimed at exploring the basic physics phenomenon of RF breakdown. We present the experimental results of a true systematic study in which the surface processing, geometry, and materials of the structures have been varied, one parameter at a time. The breakdown rate or alternatively, the probability of breakdown/pulse/meter has been recorded for different operating parameters. These statistical data reveal a strong dependence of breakdown probability on surface magnetic field, or alternatively on surface pulsed heating. This is in contrast to the classical view of electric field dependence.

  10. Abstracts of SIG Sessions.

    ERIC Educational Resources Information Center

    Proceedings of the ASIS Annual Meeting, 1997

    1997-01-01

    Presents abstracts of SIG Sessions. Highlights include digital collections; information retrieval methods; public interest/fair use; classification and indexing; electronic publication; funding; globalization; information technology projects; interface design; networking in developing countries; metadata; multilingual databases; networked…

  11. Rail-accelerator development for ultra-high-pressure research

    SciTech Connect

    Hawke, R.S.; Nellis, W.J.; Rego, J.; Susoeff, A.R.; Newman, G.H.

    1983-09-14

    During the last year, we have begun detailed development of a railgun launcher and power source. We are developing a launcher with a gas injector. The injector accelerates the projectile to more than 1 km/s reducing the dwell time of the plasma arc and the erosion of the rails. The injected projectile, with a fuse, also serves as the main switch in the power supply circuit. Current pulse shaping is used to control the applied stress to the projectile and launcher. Results of experiments with the new system will be reported and compared to computer simulations.

  12. A World Fit for Children: Millennium Development Goals; Special Session on Children Documents; The Convention on the Rights of the Child.

    ERIC Educational Resources Information Center

    United Nations Children's Fund, New York, NY.

    In May 2002, participants at the United Nations General Assembly's Special Session on Children committed to a set of specific goals for children and youth and a basic framework for meeting these goals. This report compiles the commitments that were part of the Special Session: (1) the Millennium Development Goals, earlier pledged to by all 189…

  13. Development of the brine shrimp Artemia is accelerated during spaceflight

    NASA Technical Reports Server (NTRS)

    Spooner, B. S.; Metcalf, J.; DeBell, L.; Paulsen, A.; Noren, W.; Guikema, J. A.

    1994-01-01

    Developmentally arrested brine shrimp cysts have been reactivated during orbital spaceflight on two different Space Shuttle missions (STS-50 and STS-54), and their subsequent development has been compared with that of simultaneously reactivated ground controls. Flight and control brine shrimp do not significantly differ with respect to hatching rates or larval morphology at the scanning and transmission EM levels. A small percentage of the flight larvae had defective nauplier eye development, but the observation was not statistically significant. However, in three different experiments on two different flights, involving a total of 232 larvae that developed in space, a highly significant difference in degree of flight to control development was found. By as early as 2.25 days after reactivation of development, spaceflight brine shrimp were accelerated, by a full instar, over ground control brine shrimp. Although developing more rapidly, flight shrimp grew as long as control shrimp at each developmental instar or stage.

  14. Development of the brine shrimp Artemia is accelerated during spaceflight.

    PubMed

    Spooner, B S; Metcalf, J; DeBell, L; Paulsen, A; Noren, W; Guikema, J A

    1994-07-01

    Developmentally arrested brine shrimp cysts have been reactivated during orbital spaceflight on two different Space Shuttle missions (STS-50 and STS-54), and their subsequent development has been compared with that of simultaneously reactivated ground controls. Flight and control brine shrimp do not significantly differ with respect to hatching rates or larval morphology at the scanning and transmission EM levels. A small percentage of the flight larvae had defective nauplier eye development, but the observation was not statistically significant. However, in three different experiments on two different flights, involving a total of 232 larvae that developed in space, a highly significant difference in degree of flight to control development was found. By as early as 2.25 days after reactivation of development, spaceflight brine shrimp were accelerated, by a full instar, over ground control brine shrimp. Although developing more rapidly, flight shrimp grew as long as control shrimp at each developmental instar or stage.

  15. Panel Sessions.

    ERIC Educational Resources Information Center

    Proceedings of the ASIS Mid-Year Meeting, 1992

    1992-01-01

    Lists the speakers and summarizes the issues addressed for 12 panel sessions on topics related to networking, including libraries and national networks, federal national resources and energy programs, multimedia issues, telecommuting, remote image serving, accessing the Internet, library automation, scientific information, applications of Z39.50,…

  16. Development of an accelerating-piston implosion-driven launcher

    NASA Astrophysics Data System (ADS)

    Huneault, Justin; Loiseau, Jason; Higgins, Andrew

    2013-06-01

    The ability to soft-launch projectiles at velocities exceeding 10 km/s is of interest to several scientific fields, including orbital debris impact testing and equation of state research. Current soft-launch technologies have reached a performance plateau below this operating range. The energy and power density of high explosives provides a possible avenue to reach this velocity if used to dynamically compress a light driver gas to significantly higher pressures and temperatures compared to light-gas guns. In the implosion-driven launcher (IDL), linear implosion of a pressurized tube drives a strong shock into the gas ahead of the tube pinch, thereby forming an increasingly long column of compressed gas which can be used to propel a projectile. The McGill IDL has demonstrated the ability to launch a 0.1-g projectile to 9.1 km/s. This study focuses on the implementation of a novel launch cycle wherein the explosively driven pinch is accelerated down the length of the tube in order to maintain a relatively constant projectile base pressure early in the launch cycle. The experimental development of an accelerating driver which utilizes an explosive lens to phase the detonation wave is presented. The design and experimental performance of an accelerating-piston IDL is also discussed.

  17. Development of a sealed-accelerator-tube neutron generator

    PubMed

    Verbeke; Leung; Vujic

    2000-10-01

    Sealed-accelerator-tube neutron generators are being developed in Lawrence Berkeley National Laboratory (LBNL) for applications ranging from neutron radiography to boron neutron capture therapy and neutron activation analysis. The new generation of high-output neutron generators is based on the D-T fusion reaction, producing 14.1-MeV neutrons. The main components of the neutron tube--the ion source, the accelerator and the target--are all housed in a sealed metal container without external pumping. Thick-target neutron yield computations are performed in this paper to estimate the neutron yield of titanium and scandium targets. With an average deuteron beam current of 1 A and an energy of 120 keV, a time-averaged neutron production of approximately 10(14) n/s can be estimated for a tritiated target, for both pulsed and cw operations. In mixed deuteron/triton beam operation, a beam current of 2 A at 150 keV is required for the same neutron output. Recent experimental results on ion sources and accelerator columns are presented and discussed.

  18. Latest Diagnostic Electronics Development for the PROSCAN Proton Accelerator

    SciTech Connect

    Duperrex, P.A.; Frei, U.; Gamma, G.; Mueller, U.; Rezzonico, L.

    2004-11-10

    New VME-based diagnostic electronics are being developed for PROSCAN, a proton accelerator for medical application presently under construction at PSI. One new development is a VME-based multi-channel logarithmic amplifier for converting current to voltage (LogIV). The LogIV boards are used for measuring current from the multiple wire (harp) profile monitors. The LogIV calibration method, current dependant bandwidth and temperature stability are presented. Another development is a BPM front end, based on the newest digital receiver techniques. Features of this new system are the remote control of the preamplifier stage and the continuous monitoring of each individual signal overall gain. Characteristics of the developed prototype are given.

  19. Accelerator-driven subcritical facility:Conceptual design development

    NASA Astrophysics Data System (ADS)

    Gohar, Yousry; Bolshinsky, Igor; Naberezhnev, Dmitry; Duo, Jose; Belch, Henry; Bailey, James

    2006-06-01

    A conceptual design development of an accelerator-driven subcritical facility has been carried out in the preparation of a joint activity with Kharkov Institute of Physics and Technology of Ukraine. The main functions of the facility are the medical isotope production and the support of the Ukraine nuclear industry. An electron accelerator is considered to drive the subcritical assembly. The neutron source intensity and spectrum have been studied. The energy deposition, spatial neutron generation, neutron utilization fraction, and target dimensions have been quantified to define the main target performance parameters, and to select the target material and beam parameters. Different target conceptual designs have been developed based the engineering requirements including heat transfer, thermal hydraulics, structure, and material issues. The subcritical assembly is designed to obtain the highest possible neutron flux level with a Keff of 0.98. Different fuel materials, uranium enrichments, and reflector materials are considered in the design process. The possibility of using low enrichment uranium without penalizing the facility performance is carefully evaluated. The mechanical design of the facility has been developed to maximize its utility and minimize the time for replacing the target and the fuel assemblies. Safety, reliability, and environmental considerations are included in the facility conceptual design. The facility is configured to accommodate future design improvements, upgrades, and new missions. In addition, it has large design margins to accommodate different operating conditions and parameters. In this paper, the conceptual design and the design analyses of the facility will be presented.

  20. Development of the SCRF Power Coupler for the APT Accelerator

    SciTech Connect

    Schmierer, E.N.; Lujan, R.E.; Rusnak, B.; Smith, B.; Haynes, W.B.; Gautier, C.; Waynert, J.A.; Krawczyk, F.; Gioia, J.

    1999-03-01

    The team responsible for the design of the Accelerator Production of Tritium (APT) superconducting (SC) radio frequency (RF) power coupler has developed two 700-MHz, helium gas-cooled power couplers. One has a fixed inner conductor and the other has an adjustable inner conductor (gamma prototype and alpha prototype). The power couplers will be performance tested in the near future. This paper discusses the mechanical design and fabrication techniques employed in the development of each power coupler. This includes material selection, copper coating, assembly sequences, and metal joining procedures, as well as the engineering analyses performed to determine the dynamic response of the inner conductors due to environmental excitations. A bellows is used in both prototype inner conductors in the area near the ceramic RF window, to compensate for thermal expansion and mechanical tolerance build-up. In addition, a bellows is used near the tip of the inner conductor of the alpha prototype for running the power coupler after it is installed on the accelerator. Extensive analytical work has been performed to determine the static loads transmitted by the bellows due to thermally induced expansion on the inner conductor and on the RF window. This paper also discusses this analysis, as well as the mechanical analysis performed to determine the final geometric shape of the bellows. Finally, a discussion of the electromagnetic analysis used to optimize the performance of the power couplers is included.

  1. Development and Implementation of an Advising Program’s Meet-and-Greet Session

    PubMed Central

    Candelario, Danielle M.; Bridgeman, Mary Barna

    2015-01-01

    Objective. To describe the implementation and perceptions of an advising program’s meet-and-greet session on student/faculty interactions. Design. Student advisees and faculty advisors attended a meet-and-greet program designed to facilitate introductions. Two online surveys evaluating program perceptions were electronically distributed to participants. Assessment. Twenty-eight advisors and 226 students attended; 17 faculty members and 42% (n=95) of students completed the survey. Advisors and advisees found the program valuable (100%, 85%) and recommended holding it again (100%, 93%), respectively. Most advisors agreed that the event improved success in meeting advisees while reducing time needed to schedule and meet with advisees. Students felt more comfortable contacting advisors after participating, with 83% agreeing it was more convenient than scheduling separate meeting times. Conclusion. An advising meet-and-greet program facilitated initial advisee/advisor meetings while reducing self-reported faculty time/resources. This activity could be implemented by other institutions seeking to promote student advising relationships. PMID:26889062

  2. A strategic plan to accelerate development of acute stroke treatments.

    PubMed

    Marler, John R

    2012-09-01

    In order to reenergize acute stroke research and accelerate the development of new treatments, we need to transform the usual design and conduct of clinical trials to test for small but significant improvements in effectiveness, and treat patients as soon as possible after stroke onset when treatment effects are most detectable. This requires trials that include thousands of acute stroke patients. A plan to make these trials possible is proposed. There are four components: (1) free access to the electronic medical record; (2) a large stroke emergency network and clinical trial coordinating center connected in real time to hundreds of emergency departments; (3) a clinical trial technology development center; and (4) strategic leadership to raise funds, motivate clinicians to participate, and interact with politicians, insurers, legislators, and other national and international organizations working to advance the quality of stroke care.

  3. Improving and Accelerating Drug Development for Nervous System Disorders

    PubMed Central

    Pankevich, Diana E.; Altevogt, Bruce M.; Dunlop, John; Gage, Fred H.; Hyman, Steve E.

    2014-01-01

    Advances in the neurosciences have placed the field in the position where it is poised to significantly reduce the burden of nervous system disorders. However, drug discovery, development and translation for nervous system disorders still pose many unique challenges. The key scientific challenges can be summarized as follows: mechanisms of disease, target identification and validation, predictive models, biomarkers for patient stratification and as endpoints for clinical trials, clear regulatory pathways, reliability and reproducibility of published data, and data sharing and collaboration. To accelerate nervous system drug development the Institute of Medicine’s Forum on Neuroscience and Nervous System Disorders has hosted a series of public workshops that brought together representatives of industry, government (including both research funding and regulatory agencies), academia, and patient groups to discuss these challenges and offer potential strategies to improve the translational neuroscience. PMID:25442933

  4. Highly Productive Application Development with ViennaCL for Accelerators

    NASA Astrophysics Data System (ADS)

    Rupp, K.; Weinbub, J.; Rudolf, F.

    2012-12-01

    The use of graphics processing units (GPUs) for the acceleration of general purpose computations has become very attractive over the last years, and accelerators based on many integrated CPU cores are about to hit the market. However, there are discussions about the benefit of GPU computing when comparing the reduction of execution times with the increased development effort [1]. To counter these concerns, our open-source linear algebra library ViennaCL [2,3] uses modern programming techniques such as generic programming in order to provide a convenient access layer for accelerator and GPU computing. Other GPU-accelerated libraries are primarily tuned for performance, but less tailored to productivity and portability: MAGMA [4] provides dense linear algebra operations via a LAPACK-comparable interface, but no dedicated matrix and vector types. Cusp [5] is closest in functionality to ViennaCL for sparse matrices, but is based on CUDA and thus restricted to devices from NVIDIA. However, no convenience layer for dense linear algebra is provided with Cusp. ViennaCL is written in C++ and uses OpenCL to access the resources of accelerators, GPUs and multi-core CPUs in a unified way. On the one hand, the library provides iterative solvers from the family of Krylov methods, including various preconditioners, for the solution of linear systems typically obtained from the discretization of partial differential equations. On the other hand, dense linear algebra operations are supported, including algorithms such as QR factorization and singular value decomposition. The user application interface of ViennaCL is compatible to uBLAS [6], which is part of the peer-reviewed Boost C++ libraries [7]. This allows to port existing applications based on uBLAS with a minimum of effort to ViennaCL. Conversely, the interface compatibility allows to use the iterative solvers from ViennaCL with uBLAS types directly, thus enabling code reuse beyond CPU-GPU boundaries. Out-of-the-box support

  5. Development of an accelerating piston implosion-driven launcher

    NASA Astrophysics Data System (ADS)

    Huneault, J.; Loiseau, J.; Higgins, A. J.

    2014-05-01

    The ability to soft-launch projectiles to velocities exceeding 10 km/s is of interest for a number of scientific fields, including orbital debris impact testing and equation of state research. Current soft-launch technologies have reached a performance plateau below this operating range. In the implosion-driven launcher (ILD) concept, explosives are used to dynamically compress a light driver gas to significantly higher pressures and temperatures than the propellant of conventional light-gas guns. The propellant of the IDL is compressed through the linear implosion of a pressurized tube. The imploding tube behaves like a piston which travels into the light gas at the explosive detonation velocity, thus forming an increasingly long column of shock-compressed gas which can be used to propel a projectile. The McGill designed IDL has demonstrated the ability to launch a 0.1-g projectile to 9.1 km/s. This work will focus on the implementation of a novel launch cycle in which the explosively driven piston is accelerated in order to gradually increase driver gas compression, thus maintaining a relatively constant projectile driving pressure. The theoretical potential of the concept as well as the experimental development of an accelerating piston driver will be examined.

  6. Combined carbohydrate and protein ingestion during Australian Rules football matches and training sessions does not reduce fatigue or accelerate recovery throughout a week-long junior tournament.

    PubMed

    Lee, Nathan A; Fell, James W; Pitchford, Nathan W; Hall, Andrew H; Leveritt, Michael D; Kitic, Cecilia M

    2017-03-31

    Australian Rules football (ARF) is a physically demanding sport that can induce high levels of fatigue. Fatigue may be intensified during periods where multiple matches are played with limited recovery time. Combined carbohydrate and protein (CHO+PRO) intake during physical activity may provide performance and recovery benefits. The aim of this study was to investigate whether CHO+PRO ingestion during ARF matches and training sessions throughout a tournament would enhance performance or recovery in comparison to CHO-only ingestion. ARF players (n=21) competing in a 7-day National tournament participated in this randomized and double-blinded study. Beverages containing either CHO (n=10) or CHO+PRO (n=11) were provided during matches (Day-1, Day-4 and Day-7) and training sessions (Day-2 and Day-3). Countermovement jumps (CMJ), ratings of muscle soreness and autonomic function were assessed throughout the tournament. Gastrointestinal discomfort was measured post-matches. CMJ peak velocity increased in the CHO+PRO group (p=0.01), but not for the CHO group. There were no differences in the other CMJ variables. In both groups, muscle soreness increased from Day-0 and Day-1 to Day-2 (p<0.05) but did not remain elevated. R-R intervals (time elapsed between successive peaks in QRS complexes) increased in both groups from Day-1 to Day-7 (MD=59.85 ms, p<0.01). Post-match gastrointestinal discomfort was not different (p>0.05) between groups. When daily dietary protein is adequate (>1.8 g.kg.d), the ingestion of CHO+PRO during matches and training sessions throughout a tournament does not reduce muscle soreness nor have clear benefits for neuromuscular recovery or modulate autonomic function in junior ARF athletes, compared to CHO alone.

  7. Developing an Accelerator Driven System (ADS) based on electron accelerators and heavy water

    NASA Astrophysics Data System (ADS)

    Feizi, H.; Ranjbar, A. H.

    2016-02-01

    An ADS based on electron accelerators has been developed specifically for energy generation and medical applications. Monte Carlo simulations have been performed using FLUKA code to design a hybrid electron target and the core components. The composition, geometry of conversion targets and the coolant system have been optimized for electron beam energies of 20 to 100 MeV . Furthermore, the photon and photoneutron energy spectra, distribution and energy deposition for various incoming electron beam powers have been studied. Light-heavy water of various mixtures have been used as heat removal for the targets, as γ-n converters and as neutron moderators. We have shown that an electron LINAC, as a neutron production driver for ADSs, is capable of producing a neutron output of > 3.5 × 1014 (n/s/mA). Accordingly, the feasibility of an electron-based ADS employing the designed features is promising for energy generation and high intense neutron production which have various applications such as medical therapies.

  8. Resource for the Development of Biomedical Accelerator Mass Spectrometry (AMS)

    SciTech Connect

    Turteltaub, K. W.; Bench, G.; Buchholz, B. A.; Enright, H.; Kulp, K.; McCartt, A. D.; Malfatti, M.; Ognibene, T.; Loots, G.; Stewart, B. J.

    2016-04-08

    The NIH Research Resource for Biomedical AMS was originally funded at Lawrence Livermore National Laboratory in 1999 to develop and apply the technology of accelerator mass spectrometry (AMS) in broad- based biomedical research. The Resource’s niche is to fill needs for ultra high sensitivity quantitation when isotope-labeled agents are used. The Research Resource’s Technology Research and Development (TR&D) efforts will focus on the needs of the biomedical research community in the context of seven Driving Biomedical Projects (DBPs) that will drive the Center’s technical capabilities through three core TR&Ds. We will expand our present capabilities by developing a fully integrated HPLC AMS to increase our capabilities for metabolic measurements, we will develop methods to understand cellular processes and we will develop and validate methods for the application of AMS in human studies, which is a growing area of demand by collaborators and service users. In addition, we will continue to support new and ongoing collaborative and service projects that require the capabilities of the Resource. The Center will continue to train researchers in the use of the AMS capabilities being developed, and the results of all efforts will be widely disseminated to advance progress in biomedical research. Towards these goals, our specific aims are to:1.) Increase the value and information content of AMS measurements by combining molecular speciation with quantitation of defined macromolecular isolates. Specifically, develop and validate methods for macromolecule labeling, characterization and quantitation.2.) Develop and validate methods and strategies to enable AMS to become more broadly used in human studies. Specifically, demonstrate robust methods for conducting pharmacokinetic/pharmacodynamics studies in humans and model systems.3.) Increase the accessibility of AMS to the Biomedical research community and the throughput of AMS through direct coupling to separatory

  9. Career Development. Symposium 34. [Concurrent Symposium Session at AHRD Annual Conference, 2000.

    ERIC Educational Resources Information Center

    2000

    Three presentations are provided from Symposium 34, Career Development, of the Academy of Human Resource Development (HRD) 2000 Conference Proceedings. "Emerging Career Development Needs as Reported by Adult Students at Four Ohio Institutions of Higher Education: A Qualitative Study" (Kathryn S. Hoff) reports 4 major themes emerged from…

  10. Developing Employee Competence. Symposium 25. [Concurrent Symposium Session at AHRD Annual Conference, 2000.

    ERIC Educational Resources Information Center

    2000

    This packet contains three papers from a symposium on developing employee competence. The first paper, "Coaching in Organizations: Self-Assessment of Competence" (Gary N. McLean, Min-Hsun [Christine] Kuo), reports on development and pilot-testing of an instrument to identify the developmental needs of managers and peers to function more…

  11. Accelerating Adverse Outcome Pathway Development Using Publicly Available Data Sources.

    PubMed

    Oki, Noffisat O; Nelms, Mark D; Bell, Shannon M; Mortensen, Holly M; Edwards, Stephen W

    2016-03-01

    The adverse outcome pathway (AOP) concept links molecular perturbations with organism and population-level outcomes to support high-throughput toxicity (HTT) testing. International efforts are underway to define AOPs and store the information supporting these AOPs in a central knowledge base; however, this process is currently labor-intensive and time-consuming. Publicly available data sources provide a wealth of information that could be used to define computationally predicted AOPs (cpAOPs), which could serve as a basis for creating expert-derived AOPs in a much more efficient way. Computational tools for mining large datasets provide the means for extracting and organizing the information captured in these public data sources. Using cpAOPs as a starting point for expert-derived AOPs should accelerate AOP development. Coupling this with tools to coordinate and facilitate the expert development efforts will increase the number and quality of AOPs produced, which should play a key role in advancing the adoption of HTT testing, thereby reducing the use of animals in toxicity testing and greatly increasing the number of chemicals that can be tested.

  12. Accelerating Technology Development through Integrated Computation and Experimentation

    SciTech Connect

    Shekhawat, Dushyant; Srivastava, Rameshwar D.; Ciferno, Jared; Litynski, John; Morreale, Bryan D.

    2013-08-15

    This special section of Energy & Fuels comprises a selection of papers presented at the topical conference “Accelerating Technology Development through Integrated Computation and Experimentation”, sponsored and organized by the United States Department of Energy’s National Energy Technology Laboratory (NETL) as part of the 2012 American Institute of Chemical Engineers (AIChE) Annual Meeting held in Pittsburgh, PA, Oct 28-Nov 2, 2012. That topical conference focused on the latest research and development efforts in five main areas related to fossil energy, with each area focusing on the utilization of both experimental and computational approaches: (1) gas separations (membranes, sorbents, and solvents for CO{sub 2}, H{sub 2}, and O{sub 2} production), (2) CO{sub 2} utilization (enhanced oil recovery, chemical production, mineralization, etc.), (3) carbon sequestration (flow in natural systems), (4) advanced power cycles (oxy-combustion, chemical looping, gasification, etc.), and (5) fuel processing (H{sub 2} production for fuel cells).

  13. Microphysiological models of the developing nervous system (SOT workshop session overview)

    EPA Science Inventory

    Recent advances using human stem cells and other cells that can be ushered through differentiation and developmental maturation offer an unprecedented opportunity to develop predictive systems for toxicological assessment. The use of human cells is an advantage because there is n...

  14. Design, Demand, Development, and Desire: A Symposium on the Discourses of Workplace Learning. Innovative Session.

    ERIC Educational Resources Information Center

    Dirkx, John M.; Swanson, Richard A.; Watkins, Karen E.; Cseh, Maria

    Our understanding of workplace learning is shaped by four dominant discourses that may be labeled the discourses of design, demand, development and desire. Within these different discourses, understanding of workplace learning is shaped and bounded by particular assumptions about the "self in context," which includes the organizational…

  15. 75 FR 73090 - Medicare Program; Listening Session on Development of Additional Imaging Efficiency Measures for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-29

    ..., cell phones, and palm pilots, are subject to physical inspection. We cannot assume responsibility for... measures that CMS could consider. Measure developers, hospitals, medical specialty societies, medical... medical technology costs. The imaging efficiency measures fill a significant gap in the availability...

  16. Accelerated Nuclear Energy Materials Development with Multiple Ion Beams

    SciTech Connect

    Fluss, M J; Bench, G

    2009-08-19

    A fundamental issue in nuclear energy is the changes in material properties as a consequence of time, temperature, and neutron fluence. Usually, candidate materials for nuclear energy applications are tested in nuclear reactors to understand and model the changes that arise from a combination of atomic displacements, helium and hydrogen production, and other nuclear transmutations (e.g. fission and the production of fission products). Experiments may be carried out under neutron irradiation conditions in existing nuclear materials test reactors (at rates of 10 to 20 displacements per atom (DPA) per year or burn-up rates of a few percent per year for fertile fuels), but such an approach takes much too long for many high neutron fluence scenarios (300 DPA for example) expected in reactors of the next generation. Indeed it is reasonable to say that there are no neutron sources available today to accomplish sufficiently rapid accelerated aging let alone also provide the temperature and spectral characteristics of future fast spectrum nuclear energy systems (fusion and fission both). Consequently, materials research and development progress continues to be severely limited by this bottleneck.

  17. Session: Hard Rock Penetration

    SciTech Connect

    Tennyson, George P. Jr.; Dunn, James C.; Drumheller, Douglas S.; Glowka, David A.; Lysne, Peter

    1992-01-01

    This session at the Geothermal Energy Program Review X: Geothermal Energy and the Utility Market consisted of five presentations: ''Hard Rock Penetration - Summary'' by George P. Tennyson, Jr.; ''Overview - Hard Rock Penetration'' by James C. Dunn; ''An Overview of Acoustic Telemetry'' by Douglas S. Drumheller; ''Lost Circulation Technology Development Status'' by David A. Glowka; ''Downhole Memory-Logging Tools'' by Peter Lysne.

  18. Accelerated molecular dynamics methods: introduction and recent developments

    SciTech Connect

    Uberuaga, Blas Pedro; Voter, Arthur F; Perez, Danny; Shim, Y; Amar, J G

    2009-01-01

    reaction pathways may be important, we return instead to a molecular dynamics treatment, in which the trajectory itself finds an appropriate way to escape from each state of the system. Since a direct integration of the trajectory would be limited to nanoseconds, while we are seeking to follow the system for much longer times, we modify the dynamics in some way to cause the first escape to happen much more quickly, thereby accelerating the dynamics. The key is to design the modified dynamics in a way that does as little damage as possible to the probability for escaping along a given pathway - i.e., we try to preserve the relative rate constants for the different possible escape paths out of the state. We can then use this modified dynamics to follow the system from state to state, reaching much longer times than we could reach with direct MD. The dynamics within any one state may no longer be meaningful, but the state-to-state dynamics, in the best case, as we discuss in the paper, can be exact. We have developed three methods in this accelerated molecular dynamics (AMD) class, in each case appealing to TST, either implicitly or explicitly, to design the modified dynamics. Each of these methods has its own advantages, and we and others have applied these methods to a wide range of problems. The purpose of this article is to give the reader a brief introduction to how these methods work, and discuss some of the recent developments that have been made to improve their power and applicability. Note that this brief review does not claim to be exhaustive: various other methods aiming at similar goals have been proposed in the literature. For the sake of brevity, our focus will exclusively be on the methods developed by the group.

  19. Improvement of the IVS-INT01 sessions by source selection: development and evaluation of the maximal source strategy

    NASA Astrophysics Data System (ADS)

    Gipson, John; Baver, Karen

    2016-03-01

    The primary purpose of the International very long baseline interferometry (VLBI) Service for Geodesy and Astrometry Intensive sessions is the rapid estimation of UT1-TAI. Improving the robustness and the precision of the UT1 estimates from the Intensives is an important goal. The INT01 series, which usually uses the Kokee-Wettzell baseline and runs on weekdays, is the most regular IVS Intensive series. The United States Naval Observatory which schedules these sessions traditionally used a small list of strong sources. In 2009, the authors requested and received the use of nine IVS R&D sessions for the evaluation of a new strategy which draws on all sources mutually visible on the Kokee-Wettzell baseline. Analysis of these sessions was sufficiently promising that in July 2010, USNO began to alternate the use of the original and the new strategy in scheduling the INT01 sessions to assess the operational effectiveness of the proposed strategy. In this paper, we summarize our analysis of the R&D sessions, and we also analyze 2 years of operational INT01 sessions. Considered in toto, the new strategy performs as well as, or better than, the original strategy in terms of several measures of robustness and precision. Furthermore, the RMS difference of the UT1 estimates from the 1 h operational INTO1 sessions and concurrently run 24 h VLBI sessions is 21.0 \\upmu s, compared to 30.7 \\upmu s using the standard strategy, indicating that the new strategy is, on average, 30 % more accurate.

  20. Accelerator developments since the ZGS by ZGS people

    SciTech Connect

    Cho, Y.

    1994-12-31

    The ZGS was a facility, as well as an organization, where people got together to pursue a common goal of doing exciting science of the day. In this note, the authors describe notable events related to accelerators and accelerator people since the closing of the ZGS program some 15 years ago. Many of the same ZGS people have been carrying out the state-of-the art accelerator work around the Laboratory with the same dedication that characterized their work in the earlier days. First the authors describe how the activities were re-organized after the closing of the ZGS, the migration of people, and the organizational evolution since that time. Doing this shows the similarity between the birth of the ZGS and the birth of the Advanced Photon Source (APS). Then, some of the accelerator work by the former ZGS people are described. These include: (1) Intense Pulsed Neutron Source (IPNS), (2) GeV Electron Microtron (GEM), (3) Wake Field Accelerator Test Facility, (4) Advanced Photon Source, and (5) IPNS Upgrade.

  1. Residual acceleration data on IML-1: Development of a data reduction and dissemination plan

    NASA Technical Reports Server (NTRS)

    Rogers, Melissa J. B.; Alexander, J. Iwan D.; Wolf, Randy

    1991-01-01

    A residual acceleration data analysis plan is developed that will allow principal investigators of low-gravity experiments to efficiently process their experimental results in conjunction with accelerometer data. The basic approach consisted of the following program of research: (1) identification of sensitive experiments and sensitivity ranges by order of magnitude estimates, numerical modelling, and investigator input; (2) research and development towards reduction, supplementation, and dissemination of residual acceleration data; and (3) implementation of the plan on existing acceleration data bases.

  2. Confronting Professional Values and Ethical Issues: An Innovative Session on Development of a Casebook on Ethics and Integrity. Innovative Session 4. [Concurrent Innovative Session at AHRD Annual Conference, 2000.

    ERIC Educational Resources Information Center

    Burns, Janet Z.; Hatcher, Tim; Russ-Eft, Darlene

    The Academy of Human Resource Development (AHRD) Standards on Ethics and Integrity, which were first presented in 1999, constituted one of three new initiatives to take the AHRD to a new level of leadership in the HRD profession. Although the initial standards were intentionally brief and easy to read, their application in specific situations may…

  3. Session: Offshore wind

    SciTech Connect

    Gaarde, Jette; Ram, Bonnie

    2004-09-01

    This session at the Wind Energy and Birds/Bats workshop consisted of two presentations. Due to time constraints, a discussion period was not possible. The session addressed the current state of offshore wind energy development. The first presentation ''Monitoring Program and Results: Horns Rev and Nysted'' by Jette Gaarde summarized selected environmental studies conducted to date at operating offshore wind turbine projects in Denmark and lessons from other offshore wind developments in Europe. Wildlife impacts studies from the Danish sites focused on birds, fish, and mammals. The second presentation ''What has the U.S. Wind Industry Learned from the European Example'' by Bonnie Ram provided an update on current permit applications for offshore wind developments in the U.S. as well as lessons that may be drawn from the European experience.

  4. Building Better Beginnings: A Case Study of How a Daily Physical Skills Session Is Supporting Overall Learning and Development for Young Boys

    ERIC Educational Resources Information Center

    Chalke, Joy

    2016-01-01

    This case study argues for the consideration of an adult-directed physical skills session as an approach to supporting boys learning in the Early Years Foundation Stage in England. It exemplifies a model of professional development that utilises the individual knowledge and expertise of practitioners to support and extend others' practice. It…

  5. Analytical validation of accelerator mass spectrometry for pharmaceutical development

    PubMed Central

    Keck, Bradly D; Ognibene, Ted; Vogel, John S

    2011-01-01

    The validation parameters for pharmaceutical analyses were examined for the accelerator mass spectrometry measurement of 14C/C ratio, independent of chemical separation procedures. The isotope ratio measurement was specific (owing to the 14C label), stable across samples storage conditions for at least 1 year, linear over four orders of magnitude with an analytical range from 0.1 Modern to at least 2000 Modern (instrument specific). Furthermore, accuracy was excellent (between 1 and 3%), while precision expressed as coefficient of variation was between 1 and 6% determined primarily by radiocarbon content and the time spent analyzing a sample. Sensitivity, expressed as LOD and LLOQ was 1 and 10 attomoles of 14C, respectively (which can be expressed as compound equivalents) and for a typical small molecule labeled at 10% incorporated with 14C corresponds to 30 fg equivalents. Accelerator mass spectrometry provides a sensitive, accurate and precise method of measuring drug compounds in biological matrices. PMID:21083256

  6. Analytical validation of accelerator mass spectrometry for pharmaceutical development.

    PubMed

    Keck, Bradly D; Ognibene, Ted; Vogel, John S

    2010-03-01

    The validation parameters for pharmaceutical analyses were examined for the accelerator mass spectrometry measurement of (14)C/C ratio, independent of chemical separation procedures. The isotope ratio measurement was specific (owing to the (14)C label), stable across samples storage conditions for at least 1 year, linear over four orders of magnitude with an analytical range from 0.1 Modern to at least 2000 Modern (instrument specific). Furthermore, accuracy was excellent (between 1 and 3%), while precision expressed as coefficient of variation was between 1 and 6% determined primarily by radiocarbon content and the time spent analyzing a sample. Sensitivity, expressed as LOD and LLOQ was 1 and 10 attomoles of (14)C, respectively (which can be expressed as compound equivalents) and for a typical small molecule labeled at 10% incorporated with (14)C corresponds to 30 fg equivalents. Accelerator mass spectrometry provides a sensitive, accurate and precise method of measuring drug compounds in biological matrices.

  7. Design, development, and acceleration trials of radio-frequency quadrupole

    SciTech Connect

    Rao, S. V. L. S. Jain, Piyush; Pande, Rajni; Roy, Shweta; Mathew, Jose V.; Kumar, Rajesh; Pande, Manjiri; Krishnagopal, S.; Gupta, S. K.; Singh, P.

    2014-04-15

    A deuteron radio frequency quadrupole (RFQ) accelerator has been designed, fabricated, and tested at BARC, which will be used for neutron generation. The RFQ operates at a frequency of 350 MHz and needs an inter-vane voltage of 44 kV to accelerate the deuteron beam to 400 keV within a length of 1.03 m. The error analysis shows that the offset of two opposite vanes in the same direction by 100 μm leads to a change in resonant frequency by 1.3 MHz and a significant change of fields in the quadrants (∼±40% with respect to average field). From the 3D analysis, we have observed that the unwanted dipole mode frequencies are very near to the quadrupole mode frequency which will make structure sensitive to the perturbations. In order to move the dipole modes away from the quadrupole modes, we have used the dipole stabilizer rods. The 5 wire transmission line theory was used to study the perturbative analysis of the RFQ and based on this a computer program has been written to tune the cavity to get required field distribution. Based on these studies, a 1.03 m long RFQ made of OFE copper has been fabricated and tested. Even though the RFQ was designed for deuteron (D{sup +}) beam, we tested it by accelerating both the proton (H{sup +}) and D{sup +} beams. The RFQ was operated in pulsed mode and accelerated both H{sup +} and D{sup +} beams to designed values of 200 and 400 keV, respectively. The measured parameters are in good agreement with the designed values validating our simulations and fabrication processes. In this paper, simulations, RF measurements, and beam commissioning results are presented.

  8. Flashover lithium ion source development for large pulsed power accelerators

    SciTech Connect

    Bieg, K.W.; Burns, E.J.T.; Gerber, R.A.; Olsen, J.N.; Lamppa, K.P.

    1986-05-01

    The Particle Beam Fusion Accelerator II (PBFA II), a light-ion pulsed power accelerator intended for inertial confinement fusion (ICF) applications, is currently under construction at Sandia National Laboratories. The accelerator will deliver a 30 MV, 5 MA lithium beam from an Applied-B diode to drive an ICF target. The ion source for this diode will require a thin (approx.1 mm), dense (10/sup 16/ cm/sup -2/) anode plasma layer of singly ionized lithium over an anode area of 10/sup 3/ cm/sup 2/. One type of source being investigated is the flashover ion source, which generates the anode plasma via vacuum flashover of a lithium-bearing dielectric material. Experiments with a LiF flashover source on the 0.03 TW Nereus accelerator have shown that contaminant ions account for as much as 70% of the extracted ion beam current. To overcome this, we have explored in-diode cleaning of the externally prepared anode surface by glow discharge cleaning and vacuum baking as well as in-diode preparation of the anode surface by vacuum evaporation of the lithium dielectric. Lithium-bearing dielectric materials which have been investigated include LiF, LiI, LiNO/sub 3/, and Li/sub 3/N. These techniques have resulted in a two to threefold improvement in the extracted lithium ion purity. As a result, a glow-discharge cleaned LiF flashover source will be used for initial pulsed-power testing on PBFA II.

  9. Flashover lithium ion source development for large pulsed power accelerators

    SciTech Connect

    Bieg, K.W.; Burns, E.J.T.; Gerber, R.A.; Olsen, J.N.; Lamppa, K.P.

    1985-01-01

    PBFA II, a light-ion pulsed power accelerator intended for inertial confinement fusion (ICF) applications, is currently under construction at Sandia National Laboratories. The accelerator will deliver a 30 MV, 5 MA lithium beam from an Applied-B diode to drive an ICF target. The ion source for this diode will require a thin (approx.1 mm), dense (10 W cm S) anode plasma layer of singly-ionized lithium over an anode area of 10T cmS. One type of source being investigated is the flashover ion source, which generates the anode plasma via vacuum flashover of a lithium-bearing dielectric material. Experiments with a LiF flashover source on the 0.03 TW Nereus accelerator have shown that contaminant ions account for as much as 70% of the extracted ion beam current. To overcome this, we have explored in-diode cleaning of the externally-prepared anode surface by glow discharge cleaning and vacuum baking as well as in-diode preparation of the anode surface by vacuum evaporation of the lithium dielectric. Lithium-bearing dielectric materials which have been investigated include LiF, LiI, LiNO3, and Li3N. These techniques have resulted in a two- to three-fold improvement in the extracted lithium ion purity. As a result, a glow-discharge cleaned LiF flashover source will be used for initial pulsed-power testing on PBFA II.

  10. Analysis of Male Pheromones That Accelerate Female Reproductive Organ Development

    PubMed Central

    Flanagan, Kelly A.; Webb, William; Stowers, Lisa

    2011-01-01

    Male odors can influence a female's reproductive physiology. In the mouse, the odor of male urine results in an early onset of female puberty. Several volatile and protein pheromones have previously been reported to each account for this bioactivity. Here we bioassay inbred BALB/cJ females to study pheromone-accelerated uterine growth, a developmental hallmark of puberty. We evaluate the response of wild-type and mutant mice lacking a specialized sensory transduction channel, TrpC2, and find TrpC2 function to be necessary for pheromone-mediated uterine growth. We analyze the relative effectiveness of pheromones previously identified to accelerate puberty through direct bioassay and find none to significantly accelerate uterine growth in BALB/cJ females. Complementary to this analysis, we have devised a strategy of partial purification of the uterine growth bioactivity from male urine and applied it to purify bioactivity from three different laboratory strains. The biochemical characteristics of the active fraction of all three strains are inconsistent with that of previously known pheromones. When directly analyzed, we are unable to detect previously known pheromones in urine fractions that generate uterine growth. Our analysis indicates that pheromones emitted by males to advance female puberty remain to be identified. PMID:21347429

  11. Graduate Student Program in Materials and Engineering Research and Development for Future Accelerators

    SciTech Connect

    Spentzouris, Linda

    2016-07-07

    The objective of the proposal was to develop graduate student training in materials and engineering research relevant to the development of particle accelerators. Many components used in today's accelerators or storage rings are at the limit of performance. The path forward in many cases requires the development of new materials or fabrication techniques, or a novel engineering approach. Often, accelerator-based laboratories find it difficult to get top-level engineers or materials experts with the motivation to work on these problems. The three years of funding provided by this grant was used to support development of accelerator components through a multidisciplinary approach that cut across the disciplinary boundaries of accelerator physics, materials science, and surface chemistry. The following results were achieved: (1) significant scientific results on fabrication of novel photocathodes, (2) application of surface science and superconducting materials expertise to accelerator problems through faculty involvement, (3) development of instrumentation for fabrication and characterization of materials for accelerator components, (4) student involvement with problems at the interface of material science and accelerator physics.

  12. Summary report: working group 2 on 'Plasma Based AccelerationConcepts'

    SciTech Connect

    Esarey, E.; Leemans, Wim

    1998-09-01

    A summary of the talks, papers and discussion sessions presented in the Working Group on Plasma Based Acceleration Concepts is given within the context of the progress towards a 1 GeV laser driven accelerator module. The topics covered within the Working Group were self-modulated laser wakefield acceleration, standard laser wakefield acceleration, plasma beatwave acceleration, laser guiding and wake excitation in plasma channels, plasma wakefield acceleration, plasma lenses and optical injection techniques for laser wakefield accelerators. An overview will be given of the present status of experimental and theoretical progress as well as an outlook towards the future physics and technological challenges for the development of an optimized accelerator module.

  13. Residual acceleration data on IML-1: Development of a data reduction and dissemination plan

    NASA Technical Reports Server (NTRS)

    Rogers, Melissa J. B.; Alexander, J. Iwan D.

    1993-01-01

    The research performed consisted of three stages: (1) identification of sensitive IML-1 experiments and sensitivity ranges by order of magnitude estimates, numerical modeling, and investigator input; (2) research and development towards reduction, supplementation, and dissemination of residual acceleration data; and (3) implementation of the plan on existing acceleration databases.

  14. Jefferson Lab Accelerator Operations Training and Development Program

    SciTech Connect

    Michael A. Epps

    2008-01-23

    The mission of the Jefferson Lab Operations Group is to provide safe and efficient delivery of high quality electron beam for Jefferson Laboratory's nuclear and accelerator physics programs. The Operations staff must be able to setup, transport, maintain, and troubleshoot beam to all three experimental halls in a safe, efficient, and expeditious manner. Due to the nature of shift work, high employee turnover is always as issue. This creates a unique situation where highly trained staff members must quickly be produced and maintained in order to meet the needs of the Laboratory. Some methods used to address this problem will be presented here.

  15. Session Overview

    NASA Astrophysics Data System (ADS)

    Spencer, Cherrill

    2010-02-01

    High-school teachers are amongst the most important contributors to the development of the science and technology workforce of the future. Many of the more than 23,000 US high-school physics teachers are not adequately prepared to teach the subject. Only one-third of them, for example, majored in physics or physics education. Can inadequate teacher preparation be a factor in the poor performance of US students on international assessments of their achievements in science and physics? Since 1995 the Trends in International Mathematics and Science Study (TIMSS) has been administered four times to many hundreds of thousands of students in over 60 countries. TIMSS is used to measure trends in the mathematics and science knowledge and skills of fourth- and eighth-graders. The Program for International Student Assessment (PISA) has been administered three times since 2000, it focuses on 15-year-olds' capabilities in reading literacy, mathematics literacy, and science literacy. TIMSS Advanced (1995) assessed school-leaving students who have had special preparation in advanced mathematics and physics. In all these studies the US students, including the Advanced Placement physics students, scored below the international average, sometimes in the bottom third of countries! Three speakers have been invited to talk about the physics K-12 education systems in other countries, one that consistently scores at the top of the PISA (Finland) or score much higher than the USA on TIMSS ( various Northern European countries) and significantly better on recent bi-lateral comparisons (China). What can we learn from the physics teaching systems in these high-scoring countries that might be applied in the USA? There will be a panel discussion following the 3 invited talks, audience participation will be encouraged. )

  16. Session 2

    PubMed Central

    2014-01-01

    3.1 Systems Analysis of Mitochondrial Pathogenesis Vamsi Mootha Harvard Medical School, Boston, MA, USA Mitochondrial dysfunction underlies a wide range of human diseases, including rare, monogenic diseases, common diseases, as well as the aging process itself. How cells cope with mitochondrial dysfunction is not fully understood. We performed complementary RNA, protein, and metabolite profiling of a cellular model of inducible mitochondrial dysfunction. In this talk I will describe these profiling results, as well as an adaptive pathway that they point to. The study provides insight into the pathogenesis of mitochondrial disorders 3.2 PTMomics – Towards Comprehensive Quantitative Analysis of Multiple PTMs from Biological Material Martin R. Larsen,1, Honggang Huang1, Cristina Alarcón2, Alistair V.G. Edwards1, Christopher Rhodes2, Giuseppe Palmisano3 1University of Southern Denmark, Odense, Denmark; 2University of Chicago, IL, USA; 3University of Sao Paulo, Brazil Post- or co-translational modifications (PTMs) of proteins refer to the reversible or irreversible addition of chemical modifying groups to proteins after or during their synthesis. Proteins have often multiple PTMs decorating the primary amino acid sequence and often these affect each other to produce a given function or activity of a protein. PTMomics can be defined as the global study of PTMs and is a relatively new research area aiming at understanding the function and consequences of PTMs of proteins in a cell. The success of PTMomics relies on the ability to efficiently purify the relevant PTMs and subsequently identify and characterize the nature and function of the PTM using for example mass spectrometric analysis. Previously, we have developed a number of successful methods for enrichment of phosphorylated peptides (1–3), sialylated N-linked glycopeptides (4, 5) and O-GLcNAcylated peptides (6) and we have combined some of these methods into strategies for simultaneous enrichment of several

  17. Combination of Didactic Lectures with Problem-Based Learning Sessions in Physiology Teaching in a Developing Medical College in Nepal.

    ERIC Educational Resources Information Center

    Ghosh, Sarmishtha; Dawka, Violet

    2000-01-01

    Introduces the SPICES curriculum of the Manipal College of Medical Sciences in Nepal, which is student centered, problem based, integrated, community-based, elective oriented, and systematic. Reports that the majority of students opined that the combination of didactic lectures and problem-based learning sessions were definitely beneficial.…

  18. Development of a 20 MeV Dielectric-Loaded Test Accelerator

    SciTech Connect

    Gold, S.H.; Kinkead, A.K.; Gai, W.; Power, J.G.; Konecny, R.; Jing, C.; Long, J.; Tantawi, S.G.; Nantista, C.D.; Fliflet, A.W.; Lombardi, M.; Lewis, D.; Bruce, R.W.; /Unlisted

    2007-04-13

    This paper presents a progress report on a joint project by the Naval Research Laboratory (NRL) and Argonne National Laboratory (ANL), in collaboration with the Stanford Linear Accelerator Center (SLAC), to develop a dielectric-loaded test accelerator in the magnicon facility at NRL. The accelerator will be powered by an experimental 11.424-GHz magnicon amplifier that presently produces 25 MW of output power in a {approx}250-ns pulse at up to 10 Hz. The accelerator will include a 5-MeV electron injector originally developed at the Tsinghua University in Beijing, China, and can incorporate DLA structures up to 0.5 m in length. The DLA structures are being developed by ANL, and shorter test structures fabricated from a variety of dielectric materials have undergone testing at NRL at gradients up to {approx}8 MV/m. SLAC has developed components to distribute the power from the two magnicon output arms to the injector and to the DLA accelerating structure with separate control of the power ratio and relative phase. RWBruce Associates, Inc., working with NRL, has investigated means to join short ceramic sections into a continuous accelerator tube by a brazing process using an intense 83-GHz beam. The installation and testing of the first dielectric-loaded test accelerator, including injector, DLA test structure, and spectrometer, should take place within the next year.

  19. EuCARD2: enhanced accelerator research and development in Europe

    NASA Astrophysics Data System (ADS)

    Romaniuk, Ryszard S.

    2013-10-01

    Accelerator science and technology is one of a key enablers of the developments in the particle physic, photon physics and also applications in medicine and industry. EuCARD2 is an European research project which will be realized during 2013-2017 inside the EC FP7 framework. The project concerns the development and coordination of European Accelerator Research and Development. The project is particularly important, to a number of domestic laboratories, due to some plans to build large accelerator infrastructure in Poland. Large accelerator infrastructure of fundamental and applied research character stimulates around it the development and industrial applications as well as biomedical of advanced accelerators, material research and engineering, cryo-technology, mechatronics, robotics, and in particular electronics - like networked measurement and control systems, sensors, computer systems, automation and control systems. The paper presents a digest of the European project EuCARD2 which is Enhanced European Coordination for Accelerator Research and Development. The paper presents a digest of the research results and assumptions in the domain of accelerator science and technology in Europe, shown during the final fourth annual meeting of the EuCARD - European Coordination of Accelerator R&D, and the kick-off meeting of the EuCARD2. There are debated a few basic groups of accelerator systems components like: measurement - control networks of large geometrical extent, multichannel systems for large amounts of metrological data acquisition, precision photonic networks of reference time, frequency and phase distribution, high field magnets, superconducting cavities, novel beam collimators, etc. The paper bases on the following materials: Internet and Intranet documents combined with EuCARD2, Description of Work FP7 EuCARD-2 DoW-312453, 2013-02-13, and discussions and preparatory materials worked on by Eucard-2 initiators.

  20. Development of a Compact Dielectric-Loaded Test Accelerator at 11.4 GHz

    SciTech Connect

    Gold, S. H.; Fliflet, A. W.; Kinkead, A. K.; Gai, W.; Power, J. G.; Konecny, R.; Jing, C.

    2009-01-22

    This paper presents a progress report on the development of a dielectric-loaded test accelerator in the Magnicon Facility at the Naval Research Laboratory (NRL). The accelerator will be powered by an 11.4-GHz magnicon amplifier that provides up to 25 MW of output power in a {approx}250-ns pulse at up to 10 Hz. The accelerator includes a 5-MeV electron injector originally developed at the Tsinghua University in Beijing, China, and can incorporate dielectric-loaded accelerating (DLA) structures of up to 0.5 m in length. The DLA structures are being developed by Argonne National Laboratory and Euclid Techlabs, and shorter test structures fabricated from a variety of dielectric materials have undergone rf testing at NRL at accelerating gradients up to 15 MV/m. The first stage of the accelerator, including the 5-MeV injector, has recently begun operation, and initial operation of the complete dielectric-loaded test accelerator, including injector, DLA test structure, and spectrometer, should take place within the next year.

  1. Challenging developments in three decades of accelerator mass spectrometry at ETH: from large particle accelerators to table size instruments.

    PubMed

    Suter, Martin

    2010-01-01

    Accelerator mass spectrometry (AMS) was invented for the detection of radiocarbon at natural isotopic concentrations (10(-12) to 10(-15)) more than 30 years ago. Meanwhile this method has also been applied for the analysis of many other long-lived radioisotopes, which are found at very low concentrations. The first investigations were made at large tandem accelerators originally built for nuclear physics research and operating at voltages of 6-12 MV. Today dedicated instruments are mostly used for AMS, which are optimized for associated applications. In the past 15 years, a new generation of much smaller instruments has been developed. For many years it was believed that accelerators with voltages of 2 MV or higher are needed to eliminate the molecular interferences. At these energies the ions are predominantly stripped to charge state 3+, thereby removing the binding electrons of the molecules. In contrast, the new compact facilities use 1+ or 2+ ions. In this case the molecular destruction process is based on molecule-atom collisions in the gas cell. The cross sections for this destruction are sufficiently large that the intensity of molecular components such as (12)CH(2) and (13)CH can be reduced by 10 orders of magnitude. These new facilities can be built much smaller due to the lower energies. Universal instruments providing analysis for many isotopes over the whole range of periodic table have a space requirement of about 4 x 6 m(2); dedicated radiocarbon facilities based on a 200 kV accelerator have a footprint of about 2.5 x 3 m(2). This smallest category of instruments use special technologies: The high voltage terminal with the gas stripper canal is vacuum insulated and the gas is pumped to ground potential through a ceramic pipe. A conventional 200 kV power supply provides the terminal voltage from outside. A review of this new generation of compact AMS facilities is given. Design considerations and performance of these new instruments will be presented

  2. Developments in laser wakefield accelerators: From single-stage to two-stage

    NASA Astrophysics Data System (ADS)

    Li, Wen-Tao; Wang, Wen-Tao; Liu, Jian-Sheng; Wang, Cheng; Zhang, Zhi-Jun; Qi, Rong; Yu, Chang-Hai; Li, Ru-Xin; Xu, Zhi-Zhan

    2015-01-01

    Laser wakefield accelerators (LWFAs) are compact accelerators which can produce femtosecond high-energy electron beams on a much smaller scale than the conventional radiofrequency accelerators. It is attributed to their high acceleration gradient which is about 3 orders of magnitude larger than the traditional ones. The past decade has witnessed the major breakthroughs and progress in developing the laser wakfield accelerators. To achieve the LWFAs suitable for applications, more and more attention has been paid to optimize the LWFAs for high-quality electron beams. A single-staged LWFA does not favor generating controllable electron beams beyond 1 GeV since electron injection and acceleration are coupled and cannot be independently controlled. Staged LWFAs provide a promising route to overcome this disadvantage by decoupling injection from acceleration and thus the electron-beam quality as well as the stability can be greatly improved. This paper provides an overview of the physical conceptions of the LWFA, as well as the major breakthroughs and progress in developing LWFAs from single-stage to two-stage LWFAs. Project supported by the National Natural Science Foundation of China (Grant Nos. 11127901, 11425418, and 61221064), the National Basic Research Program of China (Grant No. 2011CB808100), and the Science and Technology Talent Project of Shanghai City, China (Grant Nos. 12XD1405200 and 12ZR1451700).

  3. Group living accelerates bed bug (Hemiptera: Cimicidae) development.

    PubMed

    Saenz, Virna L; Santangelo, Richard G; Vargo, Edward L; Schal, Coby

    2014-01-01

    For many insect species, group living provides physiological and behavioral benefits, including faster development. Bed bugs (Cimex lectularius L.) live in aggregations composed of eggs, nymphs, and adults of various ages. Our aim was to determine whether bed bug nymphs reared in groups develop faster than solitary nymphs. We reared first instars either in isolation or in groups from hatching to adult emergence and recorded their development time. In addition, we investigated the effects of group housing on same-age nymphs versus nymphs reared with adults. Nymphal development was 2.2 d faster in grouped nymphs than in solitary-housed nymphs, representing 7.3% faster overall development. However, this grouping effect did not appear to be influenced by group composition. Thus, similar to other gregarious insect species, nymph development in bed bugs is faster in aggregations than in isolation.

  4. Developments and applications of accelerator system at the Wakasa Wan Energy Research Center

    NASA Astrophysics Data System (ADS)

    Hatori, S.; Kurita, T.; Hayashi, Y.; Yamada, M.; Yamada, H.; Mori, J.; Hamachi, H.; Kimura, S.; Shimoda, T.; Hiroto, M.; Hashimoto, T.; Shimada, M.; Yamamoto, H.; Ohtani, N.; Yasuda, K.; Ishigami, R.; Sasase, M.; Ito, Y.; Hatashita, M.; Takagi, K.; Kume, K.; Fukuda, S.; Yokohama, N.; Kagiya, G.; Fukumoto, S.; Kondo, M.

    2005-12-01

    At the Wakasa Wan Energy Research Center (WERC), an accelerator system with a 5 MV tandem accelerator and a 200 MeV proton synchrotron is used for ion beam analyses and irradiation experiments. The study of cancer therapy with a proton beam is also performed. Therefore, the stable operation and efficient sharing of beam time of the system are required, based on the treatment standard. Recent developments and the operation status of the system put stress on the tandem accelerator operation, magnifying the problems.

  5. Accelerated Development of a High Field Single Electron Spin Microscope

    DTIC Science & Technology

    2007-11-02

    software has been developed for that. (3) Satisfactory millimeter wave excitations have been achieved with the developed mm wave power amplifiers and strip...incoherent SESM signal – a prelude to handle quantum information. Today we can report the successful solution of all these problems, although the...been achieved with the developed mm wave power amplifiers and strip-line resonators. At the time of writing this report the SESM construction is

  6. Laboratory selection for an accelerated mosquito sexual development rate

    PubMed Central

    2011-01-01

    accelerated sexual maturation when compared with the wild strain. This outcome demonstrates the kinds of selection that can be expected during insect colonization and maintenance, particularly when generations are non-overlapping and similar-age males must compete for mates. PMID:21595988

  7. Latest Development in Superconducting RF Structures for beta=1 Particle Acceleration

    SciTech Connect

    Peter Kneisel

    2006-06-26

    Superconducting RF technology is since nearly a decade routinely applied to different kinds of accelerating devices: linear accelerators, storage rings, synchrotron light sources and FEL's. With the technology recommendation for the International Linear Collider (ILC) a year ago, new emphasis has been placed on improving the performance of accelerating cavities both in Q-value and in accelerating gradients with the goal to achieve performance levels close to the fundamental limits given by the material parameters of the choice material, niobium. This paper will summarize the challenges to SRF technology and will review the latest developments in superconducting structure design. Additionally, it will give an overview of the newest results and will report on the developments in alternative materials and technologies.

  8. Accelerating the Development of Adaptive Performance: Validating the Think Like a Commander Training

    DTIC Science & Technology

    2007-02-01

    U.S. Army Research Institute for the Behavioral and Social Sciences Research Report 1868 Accelerating the Development of Adaptive Performance...REPORT TYPE 3. DATES COVERED (from... to) February 2007 Final March 2005 to March 2006 4. TITLE AND SUBTITLE 5a. CONTRACT OR GRANT NUMBER Accelerating ...deliberate training methods may be more effective and efficient than live, virtual, or constructive experiential learning environments. 15. SUBJECT TERMS

  9. The "Session Libre".

    ERIC Educational Resources Information Center

    Roberts, J. T.

    At the Institut Universitaire de Technologie in Nancy, France, most English language teaching has been organized on a mixed extensive/intensive pattern. As a result of certain negative effects of the established "session intensive," another methodology was tried, called "session libre." This session involved several techniques:…

  10. Developing the Systems Engineering Experience Accelerator (SEEA) Prototype and Roadmap

    DTIC Science & Technology

    2012-10-24

    Figure 1: Notional Diagram of the SEEA Prototype Simulator .......................................... 1 Figure 2: A Day in the Life of a PSE ...and Program Systems Engineer ( PSE ) competency model, known as the SPRDE-SE/ PSE . 2. Developing and maturing systems thinking skills. 3. Developing...mental templates which can be applied to similar future situations Figure 2: A Day in the Life of a PSE UNCLASSIFIED Contract Number: H98230

  11. New science-based endpoints to accelerate oncology drug development.

    PubMed

    Kelloff, Gary J; Sigman, Caroline C

    2005-03-01

    Although several new oncology drugs have reached the market, more than 80% of drugs for all indications entering clinical development do not get marketing approval, with many failing late in development often in Phase III trials, because of unexpected safety issues or difficulty determining efficacy, including confounded outcomes. These factors contribute to the high costs of oncology drug development and clearly show the need for faster, more cost-effective strategies for evaluating oncology drugs and better definition of patients who will benefit from treatment. Remarkable advances in the understanding of neoplastic progression at the cellular and molecular levels have spurred the discovery of molecularly targeted drugs. This progress along with advances in imaging and bioassay technologies are the basis for describing and evaluating new biomarker endpoints as well as for defining other biomarkers for identifying patient populations, potential toxicity, and providing evidence of drug effect and efficacy. Definitions and classifications of these biomarkers for use in oncology drug development are presented in this paper. Science-based and practical criteria for validating biomarkers have been developed including considerations of mechanistic plausibility, available methods and technology, and clinical feasibility. New promising tools for measuring biomarkers have also been developed and are based on genomics and proteomics, direct visualisation by microscopy (e.g., confocal microscopy and computer-assisted image analysis of cellular features), nanotechnologies, and direct and remote imaging (e.g., fluorescence endoscopy and anatomical, functional and molecular imaging techniques). The identification and evaluation of potential surrogate endpoints and other biomarkers require access to and analysis of large amounts of data, new technologies and extensive research resources. Further, there is a requirement for a convergence of research, regulatory and drug developer

  12. Development and initial operating characteristics of the 20 megawatt linear plasma accelerator facility

    NASA Technical Reports Server (NTRS)

    Carter, A. F.; Weaver, W. R.; Mcfarland, D. R.; Wood, G. P.

    1971-01-01

    A 20-megawatt linear plasma accelerator facility, a steady flow, Faraday-type plasma accelerator facility for high velocity aerodynamic testing, was constructed, developed, and brought to an operational status. The accelerator has a 63.5-mm-square and 0.5-meter-long channel and utilizes nitrogen-seeded with 2 % mole fraction of cesium vapor. Modification of the original accelerator design characteristics and the improvements necessary to make the arc heater a suitable plasma source are described. The measured accelerator electrode current distribution and the electrode-wall potential distributions are given. The computed and the measured values are in good agreement. Measured pitot pressure indicates that an accelerator exit velocity of 9.2 km/sec, is obtained with 30 of the 36 electrode pairs powered and corresponds to a velocity increase to about 2 1/4 times the computed entrance velocity. The computed stagnation enthalpy at the accelerator exit is 92 MJ/kg, and the mass density corresponds to an altitude of about 58 km. The 92 MJ/kg stagnation enthalpy corresponds to a kinetic energy content at low temperature equivalent to a velocity of 13.6 km/sec.

  13. Sustainable Energy in Remote Indonesian Grids. Accelerating Project Development

    SciTech Connect

    Hirsch, Brian; Burman, Kari; Davidson, Carolyn; Elchinger, Michael; Hardison, R.; Karsiwulan, D.; Castermans, B.

    2015-06-30

    Sustainable Energy for Remote Indonesian Grids (SERIG) is a U.S. Department of Energy (DOE) funded initiative to support Indonesia’s efforts to develop clean energy and increase access to electricity in remote locations throughout the country. With DOE support, the SERIG implementation team consists of the National Renewable Energy Laboratory (NREL) and Winrock International’s Jakarta, Indonesia office. Through technical assistance that includes techno-economic feasibility evaluation for selected projects, government-to-government coordination, infrastructure assessment, stakeholder outreach, and policy analysis, SERIG seeks to provide opportunities for individual project development and a collective framework for national replication office.

  14. Fast Track Teaching: Beginning the Experiment in Accelerated Leadership Development

    ERIC Educational Resources Information Center

    Churches, Richard; Hutchinson, Geraldine; Jones, Jeff

    2009-01-01

    This article provides an overview of the development of the Fast Track teaching programme and personalised nature of the training and support that has been delivered. Fast Track teacher promotion rates are compared to national statistics demonstrating significant progression for certain groups, particularly women. (Contains 3 tables and 3 figures.)

  15. Follicle-stimulating hormone accelerates mouse oocyte development in vivo.

    PubMed

    Demeestere, Isabelle; Streiff, Agathe K; Suzuki, João; Al-Khabouri, Shaima; Mahrous, Enas; Tan, Seang Lin; Clarke, Hugh J

    2012-07-01

    During folliculogenesis, oocytes grow and acquire developmental competence in a mutually dependent relationship with their adjacent somatic cells. Follicle-stimulating hormone (FSH) plays an essential and well-established role in the differentiation of somatic follicular cells, but its function in the development of the oocyte has still not been elucidated. We report here that oocytes of Fshb(-/-) mice, which cannot produce FSH, grow at the same rate and reach the same size as those of wild-type mice. Consistent with this observation, the granulosa cells of Fshb(-/-) mice express the normal quantity of mRNA encoding Kit ligand, which has been implicated in oocyte growth. Oocytes of Fshb(-/-) mice also accumulate normal quantities of cyclin B1 and CDK1 proteins and mitochondrial DNA. Moreover, they acquire the ability to complete meiotic maturation in vitro and undergo transition from non-surrounded nucleolus to surrounded nucleolus. However, these events of late oocyte development are significantly delayed. Following in vitro maturation and fertilization, only a small number of embryos derived from oocytes of Fshb(-/-) mice reach the blastocyst stage. Administration of equine chorionic gonadotropin, which provides FSH activity, 48 h before in vitro maturation increases the number of blastocysts obtained subsequently. These results indicate that FSH is not absolutely required for oocyte development in vivo but that this process occurs more rapidly in its presence. We suggest that FSH may coordinate the development of the germline and somatic compartments of the follicle, ensuring that ovulation releases a developmentally competent egg.

  16. Fast economic development accelerates biological invasions in China.

    PubMed

    Lin, Wen; Zhou, Guofa; Cheng, Xinyue; Xu, Rumei

    2007-11-21

    Increasing levels of global trade and intercontinental travel have been cited as the major causes of biological invasion. However, indirect factors such as economic development that affect the intensity of invasion have not been quantitatively explored. Herein, using principal factor analysis, we investigated the relationship between biological invasion and economic development together with climatic information for China from the 1970s to present. We demonstrate that the increase in biological invasion is coincident with the rapid economic development that has occurred in China over the past three decades. The results indicate that the geographic prevalence of invasive species varies substantially on the provincial scale, but can be surprisingly well predicted using the combination of economic development (R(2) = 0.378) and climatic factors (R(2) = 0.347). Economic factors are proven to be at least equal to if not more determinant of the occurrence of invasive species than climatic factors. International travel and trade are shown to have played a less significant role in accounting for the intensity of biological invasion in China. Our results demonstrate that more attention should be paid to economic factors to improve the understanding, prediction and management of biological invasions.

  17. Advanced low-beta cavity development for proton and ion accelerators

    NASA Astrophysics Data System (ADS)

    Conway, Z. A.; Kelly, M. P.; Ostroumov, P. N.

    2015-05-01

    Recent developments in designing and processing low-beta superconducting cavities at Argonne National Laboratory are very encouraging for future applications requiring compact proton and ion accelerators. One of the major benefits of these accelerating structures is achieving real-estate accelerating gradients greater than 3 MV/m very efficiently either continuously or for long-duty cycle operation (>1%). The technology has been implemented in low-beta accelerator cryomodules for the Argonne ATLAS heavy-ion linac where the cryomodules are required to have real-estate gradients of more than 3 MV/m. In offline testing low-beta cavities with even higher gradients have already been achieved. This paper will review this work where we have achieved surface fields greater than 166 mT magnetic and 117 MV/m electric in a 72 MHz quarter-wave resonator optimized for β = 0.077 ions.

  18. Computational Tools for Accelerating Carbon Capture Process Development

    SciTech Connect

    Miller, David

    2013-01-01

    The goals of the work reported are: to develop new computational tools and models to enable industry to more rapidly develop and deploy new advanced energy technologies; to demonstrate the capabilities of the CCSI Toolset on non-proprietary case studies; and to deploy the CCSI Toolset to industry. Challenges of simulating carbon capture (and other) processes include: dealing with multiple scales (particle, device, and whole process scales); integration across scales; verification, validation, and uncertainty; and decision support. The tools cover: risk analysis and decision making; validated, high-fidelity CFD; high-resolution filtered sub-models; process design and optimization tools; advanced process control and dynamics; process models; basic data sub-models; and cross-cutting integration tools.

  19. Accelerator Developments and their Application to Cancer Therapy

    SciTech Connect

    Hirao, Yasuo

    2011-05-06

    Basic phenomena in irradiations of X-ray and particle beams and comparison among various radiations are described. Total doses and fractionations for several sites in case of carbon beam are shown in comparison with X-ray and proton beam. Typical results of carbon beam treatments are shown. Original facility was too large. Then, smaller design of 2{sup nd} stage facility of carbon therapy was carried out as well as the further technical developments.

  20. Compact Dielectric Wall Accelerator Development For Intensity Modulated Proton Therapy And Homeland Security Applications

    SciTech Connect

    Chen, Y -; Caporaso, G J; Guethlein, G; Sampayan, S; Akana, G; Anaya, R; Blackfield, D; Cook, E; Falabella, S; Gower, E; Harris, J; Hawkins, S; Hickman, B; Holmes, C; Horner, A; Nelson, S; Paul, A; Pearson, D; Poole, B; Richardson, R; Sanders, D; Stanley, J; Sullivan, J; Wang, L; Watson, J; Weir, J

    2009-06-17

    Compact dielectric wall (DWA) accelerator technology is being developed at the Lawrence Livermore National Laboratory. The DWA accelerator uses fast switched high voltage transmission lines to generate pulsed electric fields on the inside of a high gradient insulating (HGI) acceleration tube. Its high electric field gradients are achieved by the use of alternating insulators and conductors and short pulse times. The DWA concept can be applied to accelerate charge particle beams with any charge to mass ratio and energy. Based on the DWA system, a novel compact proton therapy accelerator is being developed. This proton therapy system will produce individual pulses that can be varied in intensity, energy and spot width. The system will be capable of being sited in a conventional linac vault and provide intensity modulated rotational therapy. The status of the developmental new technologies that make the compact system possible will be reviewed. These include, high gradient vacuum insulators, solid dielectric materials, SiC photoconductive switches and compact proton sources. Applications of the DWA accelerator to problems in homeland security will also be discussed.

  1. Particle Accelerators in China

    NASA Astrophysics Data System (ADS)

    Zhang, Chuang; Fang, Shouxian

    As the special machines that can accelerate charged particle beams to high energy by using electromagnetic fields, particle accelerators have been widely applied in scientific research and various areas of society. The development of particle accelerators in China started in the early 1950s. After a brief review of the history of accelerators, this article describes in the following sections: particle colliders, heavy-ion accelerators, high-intensity proton accelerators, accelerator-based light sources, pulsed power accelerators, small scale accelerators, accelerators for applications, accelerator technology development and advanced accelerator concepts. The prospects of particle accelerators in China are also presented.

  2. Pre-Implementation and Performance Plan for the Latino Development and Technology Accelerator Center

    SciTech Connect

    Quiroga, Marcelo

    2007-03-30

    This report discusses the Latino Development and Technology Accelerator Center (Center) and its innovative economic development program. The chapters describe the organization and the operations of a two-pillar model for training and business acceleration and how the program focuses on the economic development of a disadvantaged Chicago, Illinois, Hispanic community located in Humboldt Park. The Humboldt Park community is located 3 miles west of Chicago's affluent downtown. Humboldt Park residents have income levels below the poverty line and unemployment rates twice the national average.

  3. Accelerating materials discovery through the development of polymer databases

    NASA Astrophysics Data System (ADS)

    Audus, Debra

    In our line of business we create chemical solutions for a wide range of applications, such as home and personal care, printing and packaging, automotive and structural coatings, and structural plastics and foams applications. In this environment, stable and highly automated workflows suitable to handle complex systems are a must. By satisfying these prerequisites, efficiency for the development of new materials can be significantly improved by combining modeling and experimental approaches. This is in fact in line with recent Materials Genome Initiative efforts sponsored by the US administration. From our experience, we know, that valuable contributions to product development are possible today by combining existing modeling techniques in an intelligent fashion, provided modeling and experiment work closely together. In my presentation I intend to review approaches to build and parameterize soft matter systems. As an example of our standard workflow, I will show a few applications, which include the design of a stabilizer molecule for dispersing polymer particles and the simulation of polystyrene dispersions.

  4. Accelerated hepatocellular carcinoma development in CUL4B transgenic mice.

    PubMed

    Yuan, Jupeng; Jiang, Baichun; Zhang, Aizhen; Qian, Yanyan; Tan, Haining; Gao, Jiangang; Shao, Changshun; Gong, Yaoqin

    2015-06-20

    Cullin 4B (CUL4B) is a component of the Cullin 4B-Ring E3 ligase (CRL4B) complex that functions in proteolysis and in epigenetic regulation. CUL4B possesses tumor-promoting properties and is markedly upregulated in many types of human cancers. To determine the role of CUL4B in liver tumorigenesis, we generated transgenic mice that expressed human CUL4B in livers and other tissues and evaluated the development of spontaneous and chemically-induced hepatocellular carcinomas. We observed that CUL4B transgenic mice spontaneously developed liver tumors at a high incidence at old ages and exhibited enhanced DEN-induced hepatocarcinogenesis. There was a high proliferation rate in the livers of CUL4B transgenic mice that was accompanied by increased levels of Cdk1, Cdk4 and cyclin D1 and decreased level of p16. The transgenic mice also exhibited increased compensatory proliferation after DEN-induced liver injury, which was accompanied by activation of Akt, Erk, p38 and NF-κB. We also found that Prdx3 was downregulated and that DEN induced a higher level of reactive oxygen species in the livers of transgenic mice. Together, our results demonstrate a critical role of CUL4B in hepatocarcinogenesis in mice.

  5. Noninvasive Laser Probing of Ultrashort Single Electron Bunches for Accelerator And Light Source Development

    SciTech Connect

    Bolton, P.R.; /SLAC

    2007-06-11

    Companion development of ultrafast electron beam diagnostics capable of noninvasively resolving single bunch detail is essential for the development of high energy, high brightness accelerator facilities and associated beam-based light source applications. Existing conventional accelerators can exhibit timing-jitter down to the 100 femtosecond level which exceeds their single bunch duration capability. At the other extreme, in relatively jitterless environments, laser-plasma wakefield accelerators (LWFA) can generate single electron bunches of duration estimated to be of order 10 femtoseconds making this setting a valuable testbed for development of broadband electron bunch diagnostics. Characteristics of electro-optic schemes and laser-induced reflectance are discussed with emphasis on temporal resolution.

  6. Refining each process step to accelerate the development of biorefineries

    DOE PAGES

    Chandra, Richard P.; Ragauskas, Art J.

    2016-06-21

    Research over the past decade has been mainly focused on overcoming hurdles in the pretreatment, enzymatic hydrolysis, and fermentation steps of biochemical processing. Pretreatments have improved significantly in their ability to fractionate and recover the cellulose, hemicellulose, and lignin components of biomass while producing substrates containing carbohydrates that can be easily broken down by hydrolytic enzymes. There is a rapid movement towards pretreatment processes that incorporate mechanical treatments that make use of existing infrastructure in the pulp and paper industry, which has experienced a downturn in its traditional markets. Enzyme performance has also made great strides with breakthrough developments inmore » nonhydrolytic protein components, such as lytic polysaccharide monooxygenases, as well as the improvement of enzyme cocktails.The fermentability of pretreated and hydrolyzed sugar streams has been improved through strategies such as the use of reducing agents for detoxification, strain selection, and strain improvements. Although significant progress has been made, tremendous challenges still remain to advance each step of biochemical conversion, especially when processing woody biomass. In addition to technical and scale-up issues within each step of the bioconversion process, biomass feedstock supply and logistics challenges still remain at the forefront of biorefinery research.« less

  7. Accelerating development of a predictive science of climate.

    SciTech Connect

    Drake, John B; Jones, Phil

    2007-01-01

    Climate change and studies of its implications are front page news. Could the heat waves of July 2006 in Europe and the US be caused by global warming? Are increased incidences of strong tropical storms and hurricanes like Katrina to be expected? Will coastal cities be flooded due to sea level rise? The National Climatic Data Center (NCDC) which archives all weather data for the nation reports that global surface temperatures have increased at a rate near 0.6 C over the last century but that the trend is three times larger since 1976 [Easterling, 2006]. Will this rate continue or will climate change be even more abrupt? Stepping back from the flurry of questions, scientists must take a systematic approach and develop a predictive framework. With responsibility for advising on energy and technology strategies, the Department of Energy Office of Biological and Environmental Research has chosen to bolster the science of climate in order to get the story straight on the factors that cause climate change and the role of carbon loading from fossil fuel use.

  8. Refining each process step to accelerate the development of biorefineries

    SciTech Connect

    Chandra, Richard P.; Ragauskas, Art J.

    2016-06-21

    Research over the past decade has been mainly focused on overcoming hurdles in the pretreatment, enzymatic hydrolysis, and fermentation steps of biochemical processing. Pretreatments have improved significantly in their ability to fractionate and recover the cellulose, hemicellulose, and lignin components of biomass while producing substrates containing carbohydrates that can be easily broken down by hydrolytic enzymes. There is a rapid movement towards pretreatment processes that incorporate mechanical treatments that make use of existing infrastructure in the pulp and paper industry, which has experienced a downturn in its traditional markets. Enzyme performance has also made great strides with breakthrough developments in nonhydrolytic protein components, such as lytic polysaccharide monooxygenases, as well as the improvement of enzyme cocktails.The fermentability of pretreated and hydrolyzed sugar streams has been improved through strategies such as the use of reducing agents for detoxification, strain selection, and strain improvements. Although significant progress has been made, tremendous challenges still remain to advance each step of biochemical conversion, especially when processing woody biomass. In addition to technical and scale-up issues within each step of the bioconversion process, biomass feedstock supply and logistics challenges still remain at the forefront of biorefinery research.

  9. Residual acceleration data on IML-1: Development of a data reduction and dissemination plan

    NASA Technical Reports Server (NTRS)

    Rogers, Melissa J. B.; Alexander, J. Iwan D.; Wolf, Randy

    1992-01-01

    The main thrust of our work in the third year of contract NAG8-759 was the development and analysis of various data processing techniques that may be applicable to residual acceleration data. Our goal is the development of a data processing guide that low gravity principal investigators can use to assess their need for accelerometer data and then formulate an acceleration data analysis strategy. The work focused on the flight of the first International Microgravity Laboratory (IML-1) mission. We are also developing a data base management system to handle large quantities of residual acceleration data. This type of system should be an integral tool in the detailed analysis of accelerometer data. The system will manage a large graphics data base in the support of supervised and unsupervised pattern recognition. The goal of the pattern recognition phase is to identify specific classes of accelerations so that these classes can be easily recognized in any data base. The data base management system is being tested on the Spacelab 3 (SL3) residual acceleration data.

  10. The United States Particle Accelerator School: Educating the next generation of accelerator scientists and engineers

    SciTech Connect

    Barletta, William A.; /MIT

    2008-09-01

    Only a handful of universities in the US offer any formal training in accelerator science. The United States Particle Accelerator School (USPAS) is National Graduate Educational Program that has developed a highly successful educational paradigm that, over the past twenty-years, has granted more university credit in accelerator / beam science and technology than any university in the world. Sessions are held twice annually, hosted by major US research universities that approve course credit, certify the USPAS faculty, and grant course credit. The USPAS paradigm is readily extensible to other rapidly developing, crossdisciplinary research areas such as high energy density physics.

  11. The United States Particle Accelerator School: Educating the Next Generation of Accelerator Scientists and Engineers

    SciTech Connect

    Barletta, William A.

    2009-03-10

    Only a handful of universities in the US offer any formal training in accelerator science. The United States Particle Accelerator School (USPAS) is National Graduate Educational Program that has developed a highly successful educational paradigm that, over the past twenty-years, has granted more university credit in accelerator/beam science and technology than any university in the world. Sessions are held twice annually, hosted by major US research universities that approve course credit, certify the USPAS faculty, and grant course credit. The USPAS paradigm is readily extensible to other rapidly developing, cross-disciplinary research areas such as high energy density physics.

  12. The MIT Accelerator Laboratory for Diagnostic Development for OMEGA, Z and the NIF

    NASA Astrophysics Data System (ADS)

    Petrasso, R.; Gatu Johnson, M.; Armstrong, E.; Orozco, D.; Rinderknecht, H. G.; Rojas Herrera, J.; Rosenberg, M.; Sio, H.; Zylstra, A.; Frenje, J.; Li, C. K.; Seguin, F. H.; Hahn, K.; Jones, B.; Ruiz, C. L.; Sangster, T. C.

    2014-10-01

    The MIT Linear Electrostatic Ion Accelerator generates D-D and D-3He fusion products, which are used for development of nuclear diagnostics for OMEGA, Z, and the NIF. Fusion reaction rates around 106 s-1 are routinely achieved with this accelerator, and fluence and energy of the fusion products are accurately characterized. Diagnostics developed and calibrated at this facility include CR-39 based charged-particle spectrometers, neutron detectors, and the particle Time-Of-Flight (pTOF) CVD-diamond-based bang time detector. The accelerator is also a vital tool in the education of graduate and undergraduate students at MIT. This work was supported in part by SNL, DOE, LLE and LLNL.

  13. The MIT HEDP Accelerator Facility for Diagnostic Development for OMEGA, Z, and the NIF

    NASA Astrophysics Data System (ADS)

    Parker, C. E.; Gatu Johnson, M.; Birkel, A.; Kabadi, N. V.; Lahmann, B.; Milanese, L. M.; Simpson, R. A.; Sio, H.; Sutcliffe, G. D.; Wink, C.; Frenje, J. A.; Li, C. K.; Seguin, F. H.; Petrasso, R. D.; Leeper, R.; Ruiz, C. L.; Sangster, T. C.

    2016-10-01

    The MIT HEDP Accelerator Facility utilizes a 135-keV linear electrostatic ion accelerator, DT and DD neutron sources, and two x-ray sources for development and characterization of nuclear diagnostics for OMEGA, Z, and the NIF. The accelerator generates DD and D3He fusion products through the acceleration of D+ ions onto a 3He-doped Erbium-Deuteride target. Accurately characterized fusion product rates of around 106 s-1 are routinely achieved. The DT and DD neutron sources generate up to 6x108, and 1x107 neutrons/s, respectively. One x-ray generator is a thick-target W source with a peak energy of 225 keV and a maximum dose rate of 12 Gy/min; the other uses Cu, Mo, or Ti elemental tubes to generate x-rays with a maximum energy of 40 keV. Diagnostics developed and calibrated at this facility include CR-39-based charged-particle spectrometers, neutron detectors, and the particle Time-Of-Flight (pTOF) and Magnetic PTOF CVD-diamond-based bang time detectors. The accelerator is also a valuable hands-on tool for graduate and undergraduate education at MIT. This work was supported in part by the U.S. DoE, SNL, LLE and LLNL.

  14. Developing a Model of Compulsory Basic Education Completion Acceleration in Support of Millennium Development Goals in Magelang, Indonesia

    ERIC Educational Resources Information Center

    Sukarno; Haryati, Sri

    2015-01-01

    This article reports Year One of a two-year study to develop a model to accelerate compulsory basic education completion toward Millennium Development Goals (MDGs) in Magelang, Indonesia. The study focuses on five issues: (1) profile of MDGs in Magelang, (2) achievement of MDGs, (3) problems in MDGs implementation, (4) model of compulsary basic…

  15. Accelerated Learning in Adult Education and Training and Development. Trends and Issues Alert.

    ERIC Educational Resources Information Center

    Imel, Susan

    In adult education, the term "accelerated learning" (AL) is usually associated with programs designed to meet the needs of adult learners whose many commitments prevent them from participating in traditional programs. Within the field of training and development, however, AL identifies an approach to learning that is multidimensional in…

  16. Accelerated Professional Development and Peer Consultation: Two Strategies for Continuing Professional Education for Nurses.

    ERIC Educational Resources Information Center

    Hart, Gail; Clinton, Michael; Edwards, Helen; Evans, Katie; Lunney, Paul; Posner, Natasha; Tooth, Barbara; Weir, Derek; Ryan, Yoni

    2000-01-01

    A comparison was made of accelerated professional development (APD) for nurses (n=64), involving peer consultation and reflective practice, and peer consultation alone (n=30). Although APD participants had a higher completion rate, improvements in caregiver behaviors and work environment were not significantly different. (SK)

  17. Methoprene and protein supplements accelerate reproductive development and improve mating success of male tephritid flies

    Technology Transfer Automated Retrieval System (TEKTRAN)

    We have been studying the physiological mechanisms responsible for coordination of reproductive maturity and sex pheromone communication in males of tephritid flies in order to develop methods for acceleration of reproductive maturity among sterilized males. Our studies revealed that the juvenile ho...

  18. Accelerating the Early Numeracy Development of Kindergartners with Limited Working Memory Skills through Remedial Education

    ERIC Educational Resources Information Center

    Toll, Sylke W. M.; Van Luit, Johannes E. H.

    2013-01-01

    Background: Young children with limited working memory skills are a special interest group among all children that score below average on early numeracy tests. This study examines the effect of accelerating the early numeracy development of these children through remedial education, by comparing them with children with typically working memory…

  19. [Acceleration of Embryonic Development of Pinus sibirica Trees with a One-Year Reproductive Cycle].

    PubMed

    Tret'yakova, I N; Lukina, N V

    2016-01-01

    The study of the formation of embryonic structures in Pinus sibirica forms with a one-year reproductive cycle showed that the acceleration of the embryonic process manifested itself as a reduction of the coenocytic stage of the female gametophyte development (1.5 months instead of 1 year). The egg was not fertilized because of the asynchronous maturation of male and female gametophytes. Seeds without embryos were formed. We assumed that the acceleration of the reproductive process in Pinus sibirica was caused by a mutation in the female generative organs.

  20. Helicon Plasma Injector and Ion Cyclotron Acceleration Development in the VASIMR Experiment

    NASA Technical Reports Server (NTRS)

    Squire, Jared P.; Chang, Franklin R.; Jacobson, Verlin T.; McCaskill, Greg E.; Bengtson, Roger D.; Goulding, Richard H.

    2000-01-01

    In the Variable Specific Impulse Magnetoplasma Rocket (VASIMR) radio frequency (rf) waves both produce the plasma and then accelerate the ions. The plasma production is done by action of helicon waves. These waves are circular polarized waves in the direction of the electron gyromotion. The ion acceleration is performed by ion cyclotron resonant frequency (ICRF) acceleration. The Advanced Space Propulsion Laboratory (ASPL) is actively developing efficient helicon plasma production and ICRF acceleration. The VASIMR experimental device at the ASPL is called VX-10. It is configured to demonstrate the plasma production and acceleration at the 10kW level to support a space flight demonstration design. The VX-10 consists of three electromagnets integrated into a vacuum chamber that produce magnetic fields up to 0.5 Tesla. Magnetic field shaping is achieved by independent magnet current control and placement of the magnets. We have generated both helium and hydrogen high density (>10(exp 18) cu m) discharges with the helicon source. ICRF experiments are underway. This paper describes the VX-10 device, presents recent results and discusses future plans.

  1. The Public Poster Session

    ERIC Educational Resources Information Center

    Levine-Rasky, Cynthia

    2009-01-01

    This note describes the use of a student poster session as an innovative approach to student learning. The local context for the assignment is provided, followed by a description of the course for which the poster was prepared, details about the assignment including its evaluation, and practical considerations for planning a poster session. The…

  2. A Radical Poster Session.

    ERIC Educational Resources Information Center

    Gore, Paul A., Jr.; Camp, Cameron J.

    1987-01-01

    Presents the use of a poster session as an integral part of an experimental design course. Describes how the principles of experimental design are demonstrated when undergraduates design and conduct original experiments, using radishes as subjects, and present their results in a poster session. Discusses the benefits of using radishes as subjects.…

  3. The "Session Libre"

    ERIC Educational Resources Information Center

    Roberts, J. T.

    1975-01-01

    Outlines a strategy attempted as an alternative to the traditional instruction in intensive sessions of English at the Institut Universitaitre de Technologie in Nancy, France. Included were six basic activities (films, TV, press, tape library, games, and language laboratory) in a minimally-structured three-day session. (MSE)

  4. Mosaic evolution of neural development in anurans: acceleration of spinal cord development in the direct developing frog Eleutherodactylus coqui.

    PubMed

    Schlosser, Gerhard

    2003-02-01

    Previous studies have shown that spinal cord development in direct developing frogs of the genus Eleutherodactylus, which have evolutionarily lost the tadpole stage, differs from that in biphasically developing anurans (with the larval and the adult stage separated by metamorphosis). The present study of spinal cord development in Eleutherodactylus coqui provides additional information about neurogenesis, neuronal differentiation and growth analyzed by immunostaining for proliferating cell nuclear antigen (PCNA), in situ hybridization for NeuroD, and morphometric measurements in various developmental stages. Furthermore, spinal cord development in the frogs Discoglossus pictus, Xenopus laevis, and Physalaemus pustulosus, which belong to different anuran families but all exhibit biphasic development, was similarly analyzed. This comparative analysis allows inference of the ancestral anuran pattern of spinal cord development and how it has been modified during the evolution of Eleutherodactylus. All biphasically developing frogs analyzed share a similar pattern of spinal cord development, suggesting that this is ancestral for anurans: after neural tube closure, levels of proliferation and neurogenesis in the spinal cord were low throughout embryogenesis until they were upregulated drastically at early larval stages followed by development of the lateral motor columns. In contrast, no such quiescent embryonic period exists in E. coqui, where rapid growth, high levels of proliferation and neurogenesis, and early formation of lateral motor columns occur shortly after neural tube closure, while other parts of the central nervous system develop more slowly. Thus, spinal cord development has been accelerated during the evolution of Eleutherodactylus relative to the development of other parts of the central nervous system, probably related to the precocious development of limbs in this lineage.

  5. Developing The Physics Desing for NDCS-II, A Unique Pulse-Compressing Ion Accelerator

    SciTech Connect

    Friedman, A; Barnard, J J; Cohen, R H; Grote, D P; Lund, S M; Sharp, W M; Faltens, A; Henestroza, E; Jung, J; Kwan, J W; Lee, E P; Leitner, M A; Logan, B G; Vay, J -; Waldron, W L; Davidson, R C; Dorf, M; Gilson, E P; Kaganovich, I

    2009-09-24

    The Heavy Ion Fusion Science Virtual National Laboratory (a collaboration of LBNL, LLNL, and PPPL) is using intense ion beams to heat thin foils to the 'warm dense matter' regime at {approx}< 1 eV, and is developing capabilities for studying target physics relevant to ion-driven inertial fusion energy. The need for rapid target heating led to the development of plasma-neutralized pulse compression, with current amplification factors exceeding 50 now routine on the Neutralized Drift Compression Experiment (NDCX). Construction of an improved platform, NDCX-II, has begun at LBNL with planned completion in 2012. Using refurbished induction cells from the Advanced Test Accelerator at LLNL, NDCX-II will compress a {approx}500 ns pulse of Li{sup +} ions to {approx} 1 ns while accelerating it to 3-4 MeV over {approx} 15 m. Strong space charge forces are incorporated into the machine design at a fundamental level. We are using analysis, an interactive 1D PIC code (ASP) with optimizing capabilities and centroid tracking, and multi-dimensional Warpcode PIC simulations, to develop the NDCX-II accelerator. This paper describes the computational models employed, and the resulting physics design for the accelerator.

  6. DEVELOPING THE PHYSICS DESIGN FOR NDCX-II, A UNIQUE PULSE-COMPRESSING ION ACCELERATOR

    SciTech Connect

    Friedman, A.; Barnard, J. J.; Cohen, R. H.; Grote, D. P.; Lund, S. M.; Sharp, W. M.; Faltens, A.; Henestroza, E.; Jung, J-Y.; Kwan, J. W.; Lee, E. P.; Leitner, M. A.; Logan, B. G.; Vay, J.-L.; Waldron, W. L.; Davidson, R.C.; Dorf, M.; Gilson, E.P.; Kaganovich, I.

    2009-07-20

    The Heavy Ion Fusion Science Virtual National Laboratory(a collaboration of LBNL, LLNL, and PPPL) is using intense ion beams to heat thin foils to the"warm dense matter" regime at<~;; 1 eV, and is developing capabilities for studying target physics relevant to ion-driven inertial fusion energy. The need for rapid target heating led to the development of plasma-neutralized pulse compression, with current amplification factors exceeding 50 now routine on the Neutralized Drift Compression Experiment (NDCX). Construction of an improved platform, NDCX-II, has begun at LBNL with planned completion in 2012. Using refurbished induction cells from the Advanced Test Accelerator at LLNL, NDCX-II will compress a ~;;500 ns pulse of Li+ ions to ~;;1 ns while accelerating it to 3-4 MeV over ~;;15 m. Strong space charge forces are incorporated into the machine design at a fundamental level. We are using analysis, an interactive 1D PIC code (ASP) with optimizing capabilities and centroid tracking, and multi-dimensional Warpcode PIC simulations, to develop the NDCX-II accelerator. This paper describes the computational models employed, and the resulting physics design for the accelerator.

  7. Accelerated stress testing of thin film solar cells: Development of test methods and preliminary results

    NASA Technical Reports Server (NTRS)

    Lathrop, J. W.

    1985-01-01

    If thin film cells are to be considered a viable option for terrestrial power generation their reliability attributes will need to be explored and confidence in their stability obtained through accelerated testing. Development of a thin film accelerated test program will be more difficult than was the case for crystalline cells because of the monolithic construction nature of the cells. Specially constructed test samples will need to be fabricated, requiring committment to the concept of accelerated testing by the manufacturers. A new test schedule appropriate to thin film cells will need to be developed which will be different from that used in connection with crystalline cells. Preliminary work has been started to seek thin film schedule variations to two of the simplest tests: unbiased temperature and unbiased temperature humidity. Still to be examined are tests which involve the passage of current during temperature and/or humidity stress, either by biasing in the forward (or reverse) directions or by the application of light during stress. Investigation of these current (voltage) accelerated tests will involve development of methods of reliably contacting the thin conductive films during stress.

  8. Narrow bandwidth Thomson photon source and diagnostic development using laser-plasma accelerators

    NASA Astrophysics Data System (ADS)

    Geddes, Cameron G. R.; Tsai, Hai-En; van Tilborg, Jeroen; Benedetti, Carlo; Esarey, Eric; Friedman, Alex; Grote, David; Ludewigt, Bernhard; Nakamura, Kei; Quiter, Brian J.; Schroeder, Carl B.; Steinke, Sven; Swanson, Kelly; Toth, Csaba; Vay, Jean-Luc; Vetter, Kai; Zhang, Yigong; Leemans, Wim

    2017-03-01

    Compact, high-quality photon sources at MeV energies are being developed based on Laser-Plasma Accelerators (LPAs), and these sources at the same time provide precision diagnostics of beam evolution to support LPA development. We review design of experiments and laser capabilities to realize a photon source, integrating LPA acceleration for compactness, control of scattering to increase photon flux, and electron deceleration to mitigate beam dump size. These experiments are developing a compact photon source system with the potential to enable new monoenergetic photon applications currently restricted by source size, including nuclear nonproliferation. Diagnostic use of the energy-angle spectra of Thomson scattered photons is presented to support development of LPAs to meet the needs of advanced high yield/low-energy-spread photon sources and future high energy physics colliders.

  9. Analysis of requirements for accelerating the development of geothermal energy resources in California

    NASA Technical Reports Server (NTRS)

    Fredrickson, C. D.

    1978-01-01

    Various resource data are presented showing that geothermal energy has the potential of satisfying a singificant part of California's increasing energy needs. General factors slowing the development of geothermal energy in California are discussed and required actions to accelerate its progress are presented. Finally, scenarios for developing the most promising prospects in the state directed at timely on-line power are given. Specific actions required to realize each of these individual scenarios are identified.

  10. New electronic control systems for ILU accelerators, initiating the development of unique irradiation systems based on them

    NASA Astrophysics Data System (ADS)

    Bezuglov, V. V.; Bryazgin, A. A.; Vlasov, A. Y.; Kokin, E. N.; Shtarklev, E. A.

    2016-12-01

    This study is devoted to the development and industrial implementation of automated electronbeam irradiation systems based on ILU type accelerators, as well as the development of electronics and software for the creation of new technological solutions on the industrial application of accelerated electron beams. This study gives a description of the power-supply and control systems for an independent electronbeam scanning unit included in a universal one- or four-window extraction unit. The new control and protection systems for ILU accelerator pulsed power supply are also described; these systems resulted in the development of a unique 3-modulator power supply for the multiresonator ILU-14 accelerator.

  11. Can Accelerators Accelerate Learning?

    NASA Astrophysics Data System (ADS)

    Santos, A. C. F.; Fonseca, P.; Coelho, L. F. S.

    2009-03-01

    The 'Young Talented' education program developed by the Brazilian State Funding Agency (FAPERJ) [1] makes it possible for high-schools students from public high schools to perform activities in scientific laboratories. In the Atomic and Molecular Physics Laboratory at Federal University of Rio de Janeiro (UFRJ), the students are confronted with modern research tools like the 1.7 MV ion accelerator. Being a user-friendly machine, the accelerator is easily manageable by the students, who can perform simple hands-on activities, stimulating interest in physics, and getting the students close to modern laboratory techniques.

  12. A Wind-Tunnel Investigation of the Development of Lift on Wings in Accelerated Longitudinal Motion

    NASA Technical Reports Server (NTRS)

    Turner, Thomas R.

    1960-01-01

    An investigation was made in the Langley 300 MPH 7- by 10-foot tunnel to determine the development of lift on a wing during a simulated constant-acceleration catapult take-off. The investigation included models of a two-dimensional wing, an unswept wing having an aspect ratio of 6, a 35 deg. swept wing having an aspect ratio of 3.05, and a 60 deg. delta wing having an aspect ratio of 2.31. All the wings investigated developed at least 90 percent of their steady-state lift in the first 7 chord lengths of travel. The development of lift was essentially independent of the acceleration when based on chord lengths traveled, and was in qualitative agreement with theory.

  13. Progress In Plasma Accelerator Development for Dynamic Formation of Plasma Liners

    NASA Technical Reports Server (NTRS)

    Thio, Y. C. Francis; Eskridge, Richard; Martin, Adam; Smith, James; Lee, Michael; Cassibry, Jason T.; Griffin, Steven; Rodgers, Stephen L. (Technical Monitor)

    2002-01-01

    An experimental plasma accelerator for magnetic target fusion (MTF) applications under development at the NASA Marshall Space Flight Center is described. The accelerator is a coaxial pulsed plasma thruster (Figure 1). It has been tested experimentally and plasma jet velocities of approx.50 km/sec have been obtained. The plasma jet has been photographed with 10-ns exposure times to reveal a stable and repeatable plasma structure (Figure 2). Data for velocity profile information has been obtained using light pipes and magnetic probes embedded in the gun walls to record the plasma and current transit respectively at various barrel locations. Preliminary spatially resolved spectral data and magnetic field probe data are also presented. A high speed triggering system has been developed and tested as a means of reducing the gun "jitter". This jitter is being characterized and future work for second generation "ultra-low jitter" gun development is being identified.

  14. Plasma Accelerator Development for Dynamic Formation of Plasma Liners: A Status Report

    NASA Technical Reports Server (NTRS)

    Thio, Y. C. Francis; Eskridge, Richard; Martin, Adam; Smith, James; Lee, Michael; Rodgers, Stephen L. (Technical Monitor)

    2001-01-01

    An experimental plasma accelerator for magnetic target fusion (MTF) applications under development at the NASA Marshall Space Flight Center is described. The accelerator is a pulsed plasma thruster and has been tested experimentally and plasma jet velocities of approximately 50 km/sec have been obtained. The plasma jet structure has been photographed with 10 ns exposure times to reveal a stable and repeatable plasma structure. Data for velocity profile information has been obtained using light pipes embedded in the gun walls to record the plasma transit at various barrel locations. Preliminary spatially resolved spectral data and magnetic field probe data are also presented. A high speed triggering system has been developed and tested as a means of reducing the gun "jitter". This jitter is being characterized and future work for second generation "ultra-low jitter" gun development is being identified.

  15. 1975 Revised Guide to the Rural Development Act of 1972. 93d Congress, 2d Session, January 1, 1975.

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. Senate Committee on Agriculture, Nutrition, and Forestry.

    Prepared to assist both the Congress and the public involved in Rural Development (RD), the 1975 Revised Guide to the Rural Development Act of 1972 provides definitive and implemental information. Part 1 deals with the Act itself, detailing its purpose, historical perspective, and major provisions. Divided into three areas of concern, Part 2 deals…

  16. Teachers' Support in Using Computers for Developing Students' Listening and Speaking Skills in Pre-Sessional English Courses

    ERIC Educational Resources Information Center

    Zou, Bin

    2013-01-01

    Many computer-assisted language learning (CALL) studies have found that teacher direction can help learners develop language skills at their own pace on computers. However, many teachers still do not know how to provide support for students to use computers to reinforce the development of their language skills. Hence, more examples of CALL…

  17. CEC Council Sessions

    EPA Pesticide Factsheets

    Each year, the North American Ministers to the Commission for Environmental Cooperation meet at least once for the CEC Council Session to set the CEC’s overall direction, including budget, and activities pursued through the cooperative work plan.

  18. openSE: a Systems Engineering Framework Particularly Suited to Particle Accelerator Studies and Development Projects

    SciTech Connect

    Bonnal, P.; Féral, B.; Kershaw, K.; Nicquevert, B.; Baudin, M.; Lari, L.; Le Cardinal, J.

    2016-07-15

    Particle accelerator projects share many characteristics with industrial projects. However, experience has shown that best practice of industrial project management is not always well suited to particle accelerator projects. Major differences include the number and complexity of technologies involved, the importance of collaborative work, development phases that can last more than a decade, and the importance of telerobotics and remote handling to address future preventive and corrective maintenance requirements due to induced radioactivity, to cite just a few. The openSE framework it is a systems engineering and project management framework specifically designed for scientific facilities’ systems and equipment studies and development projects. Best practices in project management, in systems and requirements engineering, in telerobotics and remote handling and in radiation safety management were used as sources of inspiration, together with analysis of current practices surveyed at CERN, GSI and ESS.

  19. A linear electrostatic accelerator for education and advanced diagnostics development for OMEGA and the NIF

    NASA Astrophysics Data System (ADS)

    Sinenian, N.; Gatu Johnson, M.; Sio, H.; Waugh, C.; Orozco, D.; Penna, J.; Rinderknecht, H.; Rosenberg, M.; Zylstra, A.; Frenje, J.; Li, C. K.; Seguin, F.; Petrasso, R.; Ruiz, C.; Sangster, T.; Leeper, R.; Kilkenny, J.

    2013-10-01

    The MIT Linear Electrostatic Accelerator generates D-D and D-3He fusion products, which are used for development of nuclear diagnostics for OMEGA and the NIF. Fusion reaction rates of about 106 s-1 are routinely achieved, and fluence and energy of the fusion products have been accurately characterized. Diagnostics developed and calibrated at this facility include CR-39 based charged-particle spectrometers, neutron detectors, and the particle Time-Of-Flight (pTOF) CVD-diamond-based bang time detector. The accelerator is also a vital tool in the education of graduate and undergraduate students at MIT. This work was supported in part by SNL, DOE, LLE and LLNL.

  20. Energy and Water Development Appropriation Bill, 1985. Report submitted by the Committee on Appropriations U. S. Senate, to the Ninety-Eighth Congress, Second Session, June 5, 1984

    SciTech Connect

    Not Available

    1984-01-01

    The Committee report on H.R. 5653 includes suggested amendments and information on the recommended changes in energy and water development appropriations for fiscal year 1985. Title I of the bill supplies funds for civilian projects of the Army Corps of Engineers; Title II, for reclamation projects of the Department of the Interior; Title III, for DOE defense, research, regulatory, geothermal, nuclear waste, power marketing, and uranium supply and enrichment activities; and Title IV, for independent agencies, including the Appalachian Regional Commission, Nuclear Regulatory Commission, and the Tennessee Valley Authority. The committee's recommendation of nearly $15.4 billion is $99.6 million below the budget estimates. The report covers information gathered during 17 hearing sessions, and represents a unanimous recommmendation by the committee.

  1. Priority research areas to accelerate the development of practical ultraconductive copper conductors

    SciTech Connect

    Lee, Dominic F.; Burwell, Malcolm; Stillman, H.

    2015-09-01

    This report documents the findings at an Ultraconductive Copper Strategy Meeting held on March 11, 2015 in Washington DC. The aim of this meeting was to bring together researchers of ultraconductive copper in the U.S. to identify and prioritize critical non-proprietary research activities that will enhance the understanding in the material and accelerate its development into practical conductors. Every effort has been made to ensure that the discussion and findings are accurately reported in this document.

  2. Design and Development Tools for the Systems Engineering Experience Accelerator. Volume 1

    DTIC Science & Technology

    2015-04-20

    INCOSE) 2012 International Symposium/European Conference on Systems Engineering (EUSEC), Rome , Italy, July 9-12. • Bodner, D., Wade, J., Squires, A...Editor in War Craft III. The map is named Defense of the Ancients (DotA) and has attracted millions of players using it for gaming worldwide. Since its... Rome , Italy. 7. Wade, J. P., "Design and Development Tools for the Systems Engineering Experience Accelerator," Systems Engineering Research

  3. Development of the C{sup 6+} laser ablation ion source for the KEK digital accelerator

    SciTech Connect

    Munemoto, Naoya; Takayama, Ken; Takano, Susumu; Okamura, Masahiro; Kumaki, Masahumi

    2014-02-15

    A laser ion source that provides a fully ionized carbon ion beam is under joint development at the High Energy Accelerator Research Organization and Brookhaven National Laboratory. Long-pulse (6 ns) and short-pulse (500 ps) laser systems were tested by using them to irradiate a graphite target. Notable differences between the systems were observed in these experiments. Preliminary experimental results, such as the charge-state spectrum, beam intensity, and stability, are discussed.

  4. Development and beam test of a continuous wave radio frequency quadrupole accelerator

    NASA Astrophysics Data System (ADS)

    Ostroumov, P. N.; Mustapha, B.; Barcikowski, A.; Dickerson, C.; Kolomiets, A. A.; Kondrashev, S. A.; Luo, Y.; Paskvan, D.; Perry, A.; Schrage, D.; Sharamentov, S. I.; Sommer, R.; Toter, W.; Zinkann, G.

    2012-11-01

    The front end of any modern ion accelerator includes a radio frequency quadrupole (RFQ). While many pulsed ion linacs successfully operate RFQs, several ion accelerators worldwide have significant difficulties operating continuous wave (CW) RFQs to design specifications. In this paper we describe the development and results of the beam commissioning of a CW RFQ designed and built for the National User Facility: Argonne Tandem Linac Accelerator System (ATLAS). Several innovative ideas were implemented in this CW RFQ. By selecting a multisegment split-coaxial structure, we reached moderate transverse dimensions for a 60.625-MHz resonator and provided a highly stabilized electromagnetic field distribution. The accelerating section of the RFQ occupies approximately 50% of the total length and is based on a trapezoidal vane tip modulation that increased the resonator shunt impedance by 60% in this section as compared to conventional sinusoidal modulation. To form an axially symmetric beam exiting the RFQ, a very short output radial matcher with a length of 0.75βλ was developed. The RFQ is designed as a 100% oxygen-free electronic (OFE) copper structure and fabricated with a two-step furnace brazing process. The radio frequency (rf) measurements show excellent rf properties for the resonator, with a measured intrinsic Q equal to 94% of the simulated value for OFE copper. An O5+ ion beam extracted from an electron cyclotron resonance ion source was used for the RFQ commissioning. In off-line beam testing, we found excellent coincidence of the measured beam parameters with the results of beam dynamics simulations performed using the beam dynamics code TRACK, which was developed at Argonne. These results demonstrate the great success of the RFQ design and fabrication technology developed here, which can be applied to future CW RFQs.

  5. Requirements and Development of an Acceleration Measurement System for International Space Station Microgravity Science Payloads

    NASA Technical Reports Server (NTRS)

    Sutliff, Thomas J.

    1997-01-01

    The International Space Station is being developed by NASA and international partners as a versatile user platform to allow long term on-orbit investigations of a variety of scientific and technology arenas. In particular, scientific studies are planned within a research class known as microgravity science in areas such as biotechnology, combustion, fluid physics, and materials sciences. An acceleration measurement system is in development to aid such research conducted in the on-orbit conditions of apparent weightlessness. This system provides a general purpose acceleration measurement capability in support of these payloads and investigators. Such capability allows for systematic study of scientific phenomena by obtaining information regarding the local accelerations present during experiment operations. Preparations for implementing this flight measurement system involves two distinct stages: requirements development prior to initiating the design activity, and the design activity itself. This paper defines the requirements definition approach taken, provides an overview of the results of the requirements phase, and outlines the initial design considerations being addressed for this measurement system. Some preliminary engineering approaches are also described.

  6. The trade-off between maturation and growth during accelerated development in frogs.

    PubMed

    Mueller, Casey A; Augustine, Starrlight; Kooijman, Sebastiaan A L M; Kearney, Michael R; Seymour, Roger S

    2012-09-01

    Developmental energetics are crucial to a species' life history and ecology but are poorly understood from a mechanistic perspective. Traditional energy and mass budgeting does not distinguish between costs of growth and maturation, making it difficult to account for accelerated development. We apply a metabolic theory that uniquely considers maturation costs (Dynamic Energy Budget theory, DEB) to interpret empirical data on the energetics of accelerated development in amphibians. We measured energy use until metamorphosis in two related frogs, Crinia georgiana and Pseudophryne bibronii. Mass and energy content of fresh ova were comparable between the species. However, development to metamorphosis was 1.7 times faster in C. georgiana while P. bibronii produced nine times the dry biomass at metamorphosis and had lower mass-specific oxygen requirements. DEB theory explained these patterns through differences in ontogenetic energy allocation to maturation. P. bibronii partitioned energy in the same (constant) way throughout development whereas C. georgiana increased the fraction of energy allocated to maturation over growth between hatching and the onset of feeding. DEB parameter estimation for additional, direct-developing taxa suggests that a change in energy allocation during development may result from a selective pressure to increase development rate, and not as a result of development mode.

  7. Attenuated hypothalamic-pituitary-adrenal axis functioning predicts accelerated pubertal development in girls 1 year later.

    PubMed

    Saxbe, Darby E; Negriff, Sonya; Susman, Elizabeth J; Trickett, Penelope K

    2015-08-01

    Accelerated pubertal development has been linked to adverse early environments and may heighten subsequent mental and physical health risks. Hypothalamic-pituitary-adrenal axis functioning has been posited as a mechanism whereby stress may affect pubertal development, but the literature lacks prospective tests of this mechanism. The current study assessed 277 youth (M = 10.84 years, SD = 1.14), 138 boys and 139 girls, who reported on their pubertal development and underwent the Trier Social Stress Test for Children at baseline and returned to the laboratory approximately 1 year later (M = 1.12 years, range = 0.59-1.98 years). For girls, lower cortisol area under the curve (with respect to ground) at Time 1 predicted more advanced pubertal development at Time 2, controlling for Time 1 pubertal development. This association persisted after additional covariates including age, body mass index, race, and maltreatment history were introduced, and was driven by adrenal rather than gonadal development. Cortisol was not linked to boys' subsequent pubertal development, and no interaction by gender or by maltreatment appeared. These results suggest that attenuated cortisol, reported in other studies of children exposed to early adversity, may contribute to accelerated pubertal tempo in girls.

  8. Development of an ion beam analyzing system for the KBSI heavy-ion accelerator

    SciTech Connect

    Bahng, Jungbae; Hong, Jonggi; Park, Jin Yong; Kim, Seong Jun; Ok, Jung-Woo; Choi, Seyong; Shin, Chang Seouk; Yoon, Jang-Hee; Won, Mi-Sook; Lee, Byoung-Seob; Kim, Eun-San

    2016-02-15

    The Korea Basic Science Institute (KBSI) has been developing a heavy ion accelerator system to accelerate high current, multi-charge state ions produced by a 28 GHz superconducting electron cyclotron ion source. A beam analyzing system as a part of the low energy beam transport apparatus was developed to select charged particles with desirable charge states from the ion beams. The desired species of ion, which is generated and extracted from the ECR ion source including various ion particles, can be selected by 90° dipole electromagnet. Due to the non-symmetrical structure in the coil as well as the non-linear permeability of the yoke material coil, a three dimensional analysis was carried out to confirm the design parameters. In this paper, we present the experimental results obtained as result of an analysis of KBSI accelerator. The effectiveness of beam selection was confirmed during the test of the analyzing system by injecting an ion beam from an ECR ion source.

  9. Development of an ion beam analyzing system for the KBSI heavy-ion accelerator

    NASA Astrophysics Data System (ADS)

    Bahng, Jungbae; Hong, Jonggi; Park, Jin Yong; Kim, Seong Jun; Ok, Jung-Woo; Choi, Seyong; Shin, Chang Seouk; Yoon, Jang-Hee; Won, Mi-Sook; Lee, Byoung-Seob; Kim, Eun-San

    2016-02-01

    The Korea Basic Science Institute (KBSI) has been developing a heavy ion accelerator system to accelerate high current, multi-charge state ions produced by a 28 GHz superconducting electron cyclotron ion source. A beam analyzing system as a part of the low energy beam transport apparatus was developed to select charged particles with desirable charge states from the ion beams. The desired species of ion, which is generated and extracted from the ECR ion source including various ion particles, can be selected by 90° dipole electromagnet. Due to the non-symmetrical structure in the coil as well as the non-linear permeability of the yoke material coil, a three dimensional analysis was carried out to confirm the design parameters. In this paper, we present the experimental results obtained as result of an analysis of KBSI accelerator. The effectiveness of beam selection was confirmed during the test of the analyzing system by injecting an ion beam from an ECR ion source.

  10. New Accelerated Testing and Lifetime Modeling Methods Promise Faster Development of More Durable MEAs

    SciTech Connect

    Pierpont, D. M.; Hicks, M. T.; Turner, P. L.; Watschke, T. M.

    2005-11-01

    For the successful commercialization of fuel cell technology, it is imperative that membrane electrode assembly (MEA) durability is understood and quantified. MEA lifetimes of 40,000 hours remain a key target for stationary power applications. Since it is impractical to wait 40,000 hours for durability results, it is critical to learn as much information as possible in as short a time period as possible to determine if an MEA sample will survive past its lifetime target. Consequently, 3M has utilized accelerated testing and statistical lifetime modeling tools to develop a methodology for evaluating MEA lifetime. Construction and implementation of a multi-cell test stand have allowed for multiple accelerated tests and stronger statistical data for learning about durability.

  11. Update on the development of externally powered dielectric-loaded accelerating structures.

    SciTech Connect

    Jing, C.; Gai, W.; Konecny, R.; Power, J. G.; Liu, W.; Kanareykin, A.; Gold, S.; Kinkead, A. K.; High Energy Physics; EuclidTechlabs,; Naval Research Lab.; Icarus Research

    2009-01-01

    We report on recent progress in a program to develop an RF-driven Dielectric-Loaded Accelerating (DLA) structure, capable of supporting high gradient acceleration. Previous high power tests revealed that the earlier DLA structures suffered from multipactor and arcing at the dielectric joint. A few new DLA structures have been designed to alleviate this limitation including the coaxial coupler based DLA structure and the clamped DLA structure. These structures were recently fabricated and high power tested at the NRL X-band Magnicon facility. Results show the multipactor can be reduced by the TiN coating on the dielectric surface. Gradient of 15 MV/m has also been tested without dielectric breakdown in the test of the clamped DLA structure. Detailed results are reported, and future plans discussed.

  12. Update on the Development of Externally Powered Dielectric-Loaded Accelerating Structures

    SciTech Connect

    Jing, C.; Kanareykin, A.; Gai, W.; Konecny, R.; Power, J. G.; Liu, W.; Gold, S. H.; Kinkead, A. K.

    2009-01-22

    We report on recent progress in a program to develop an RF-driven Dielectric-Loaded Accelerating (DLA) structure, capable of supporting high gradient acceleration. Previous high power tests revealed that the earlier DLA structures suffered from multipactor and arcing at the dielectric joint. A few new DLA structures have been designed to alleviate this limitation including the coaxial coupler based DLA structure and the clamped DLA structure. These structures were recently fabricated and high power tested at the NRL X-band Magnicon facility. Results show the multipactor can be reduced by the TiN coating on the dielectric surface. Gradient of 15 MV/m has also been tested without dielectric breakdown in the test of the clamped DLA structure. Detailed results are reported, and future plans discussed.

  13. Introduction to Session 1B

    NASA Astrophysics Data System (ADS)

    Sticklen, Mariam B.

    Topics presented in the "Plant Biotechnology and Genomics" session focused on technologies that highlight the important role of plant biotechnology and genomics in the development of future energy crops. Several excellent presentations demonstrated the latest advances in energy crop development through the use of plant cell wall regulation and by engineering new energy crops such as brown midrib sweet sorghum. Approaches included the control of cellulose production by increased expression of cellulase synthase genes and the selection of high-yield varieties of shrub willows. The potential of producing hydrolytic enzymes using transgenic plants as a cost-effective means for the large-scale production of these enzymes was also explored in the session, as was the role of posttranslational modifications on the activities of heterologous expressed cellulases in hosts such as Pichia pastoris.

  14. Recent developments in rf superconductivity for high-brightness and high-gradient ion beam accelerators

    SciTech Connect

    Delayen, J.R.; Bohn, C.L.; Kennedy, W.L.; Nichols, G.L.; Roche, C.T.; Sagalovsky, L.

    1992-02-01

    Recent progress in on-going development program leading to the design of superconducting continuous-wave (cw) linear accelerators for high-brightness ion beams is reviewed. A new spoke-resonator geometry incorporating a half-wavelength resonant line was fabricated and tested. This geometry serves as the basis for the constituent cavities of a superconducting section being designed for high-current testing with a deuterium beam. Considerable progress has been made in the design of this section. A multi-phased program leading to the development of a superconducting radio-frequency quadrupole (SCRFQ) has been initiated. Design considerations and test results from the various activities are presented.

  15. Recent developments in rf superconductivity for high-brightness and high-gradient ion beam accelerators

    SciTech Connect

    Delayen, J.R.; Bohn, C.L.; Kennedy, W.L.; Nichols, G.L.; Roche, C.T.; Sagalovsky, L.

    1992-01-01

    Recent progress in on-going development program leading to the design of superconducting continuous-wave (cw) linear accelerators for high-brightness ion beams is reviewed. A new spoke-resonator geometry incorporating a half-wavelength resonant line was fabricated and tested. This geometry serves as the basis for the constituent cavities of a superconducting section being designed for high-current testing with a deuterium beam. Considerable progress has been made in the design of this section. A multi-phased program leading to the development of a superconducting radio-frequency quadrupole (SCRFQ) has been initiated. Design considerations and test results from the various activities are presented.

  16. Education and Skills for Development in South Africa: Reflections on the Accelerated and Shared Growth Initiative for South Africa

    ERIC Educational Resources Information Center

    McGrath, S.; Akoojee, Salim

    2007-01-01

    In July 2005, President Mbeki announced the launch of the Accelerated and Shared Growth Initiative for South Africa (AsgiSA), a new development strategy designed to help the South African state meet the ANC's 2004 election pledges, namely: (1) halve unemployment; (2) halve poverty; (3) accelerate employment equity; and (4) improve broad-based…

  17. Summary of Session 2: Data analysis—algorithms and tools

    NASA Astrophysics Data System (ADS)

    Kiesling, C.

    2006-04-01

    This report summarizes the Session 2 ("Data Analysis—Algorithms and Tools"), reviewing shortly the evolvement of this session during the series of ACAT workshops, emphasizing the highlights and recent developments of methods presented at this workshop, and presenting some thoughts as regards to the possible future development of the session within the ACAT workshop series.

  18. Country breakout session highlights.

    PubMed

    Ghezzi, Angelo; Filli, Linard; Solaro, Claudio; Mekies, Claude; Landete, Lamberto; Lycke, Jan

    2016-12-01

    At the 2016 MS Experts Summit, country-relevant aspects pertaining to the management of symptoms and disability in multiple sclerosis (MS), with emphasis on those associated with spasticity, were explored in interactive country breakout sessions chaired by selected MS experts. Attendees had the opportunity to review and discuss topics in their own native language. After feedback from each session leader, key messages were collated and presented in a Plenary Session by Summit chair, Professor Angelo Ghezzi. Topics at this year's Summit included: gait tracking (Germany/Switzerland); the Care Alliance against MS spasticity (Italy); MS spasticity and associated symptoms (France); improvement in MS symptoms and functionality and patients' independence (Spain); Swedish MS guidelines (Sweden/Rest of World).

  19. Accelerating vaccine development and deployment: report of a Royal Society satellite meeting

    PubMed Central

    Bregu, Migena; Draper, Simon J.; Hill, Adrian V. S.; Greenwood, Brian M.

    2011-01-01

    The Royal Society convened a meeting on the 17th and 18th November 2010 to review the current ways in which vaccines are developed and deployed, and to make recommendations as to how each of these processes might be accelerated. The meeting brought together academics, industry representatives, research sponsors, regulators, government advisors and representatives of international public health agencies from a broad geographical background. Discussions were held under Chatham House rules. High-throughput screening of new vaccine antigens and candidates was seen as a driving force for vaccine discovery. Multi-stakeholder, small-scale manufacturing facilities capable of rapid production of clinical grade vaccines are currently too few and need to be expanded. In both the human and veterinary areas, there is a need for tiered regulatory standards, differentially tailored for experimental and commercial vaccines, to allow accelerated vaccine efficacy testing. Improved cross-fertilization of knowledge between industry and academia, and between human and veterinary vaccine developers, could lead to more rapid application of promising approaches and technologies to new product development. Identification of best-practices and development of checklists for product development plans and implementation programmes were seen as low-cost opportunities to shorten the timeline for vaccine progression from the laboratory bench to the people who need it. PMID:21893549

  20. Accelerated development of CuSbS2 thin film photovoltaic device prototypes

    SciTech Connect

    Welch, Adam W.; Baranowski, Lauryn L.; Zawadzki, Pawel; DeHart, Clay; Johnston, Steve; Lany, Stephan; Wolden, Colin A.; Zakutayev, Andriy

    2016-02-03

    Development of alternative thin film photovoltaic technologies is an important research topic because of the potential of low-cost, high-efficiency solar cells to produce terawatt levels of clean power. However, this development of unexplored yet promising absorbers can be hindered by complications that arise during solar cell fabrication. Here, a high-throughput combinatorial method is applied to accelerate development of photovoltaic devices, in this case, using the novel CuSbS2 absorber via a newly developed three-stage self-regulated growth process to control absorber purity and orientation. Photovoltaic performance of the absorber, using the typical substrate CuInxGa1 - xSe2 (CIGS) device architecture, is explored as a function of absorber quality and thickness using a variety of back contacts. This study yields CuSbS2 device prototypes with ~1% conversion efficiency, suggesting that the optimal CuSbS2 device fabrication parameters and contact selection criteria are quite different than for CIGS, despite the similarity of these two absorbers. The CuSbS2 device efficiency is at present limited by low short-circuit current because of bulk recombination related to defects, and a small open-circuit voltage because of a theoretically predicted cliff-type conduction band offset between CuSbS2 and CdS. Overall, these results illustrate both the potential and limits of combinatorial methods to accelerate the development of thin film photovoltaic devices using novel absorbers.

  1. Performance and Environmental Test Results of the High Voltage Hall Accelerator Engineering Development Unit

    NASA Technical Reports Server (NTRS)

    Kamhawi, Hani; Haag, Thomas; Huang, Wensheng; Shastry, Rohit; Pinero, Luis; Peterson, Todd; Mathers, Alex

    2012-01-01

    NASA Science Mission Directorate's In-Space Propulsion Technology Program is sponsoring the development of a 3.5 kW-class engineering development unit Hall thruster for implementation in NASA science and exploration missions. NASA Glenn and Aerojet are developing a high fidelity high voltage Hall accelerator that can achieve specific impulse magnitudes greater than 2,700 seconds and xenon throughput capability in excess of 300 kilograms. Performance, plume mappings, thermal characterization, and vibration tests of the high voltage Hall accelerator engineering development unit have been performed. Performance test results indicated that at 3.9 kW the thruster achieved a total thrust efficiency and specific impulse of 58%, and 2,700 sec, respectively. Thermal characterization tests indicated that the thruster component temperatures were within the prescribed material maximum operating temperature limits during full power thruster operation. Finally, thruster vibration tests indicated that the thruster survived the 3-axes qualification full-level random vibration test series. Pre and post-vibration test performance mappings indicated almost identical thruster performance. Finally, an update on the development progress of a power processing unit and a xenon feed system is provided.

  2. Vocal sac development and accelerated sexual maturity in the lesser swimming frog, Pseudis minuta (Anura, Hylidae).

    PubMed

    Goldberg, Javier; Barrasso, Diego A; Agostini, M Gabriela; Quinzio, Silvia

    2016-12-01

    Sexual maturity involves the differentiation of the reproductive system, the maturation of germ cells, and the development of secondary sexual characteristics. Even though this topic has received much attention, little is known about the sequence of events that encompass reproductive maturation in anurans and what it could reveal about the developmental basis of life cycle evolution. The discovery of froglets of Pseudis minuta with incipient vocal sacs calling in breeding pools alongside several larger adult specimens with fully developed vocal sacs raised the question of the timing of sexual maturity in this species. Here we describe the sequence and timing of differentiation, development and maturation of the vocal sac apparatus and the testes in P. minuta (Anura, Hylidae), in order to establish a timeline of events leading to sexual maturity. Differentiation of the vocal sac apparatus begins at the final metamorphic stages, earlier than reported for other species, and the vocal sac acquires its final shape during the early postmetamorphic period. These modifications occur after gonadal differentiation, which begins early during the larval period and proceeds with a highly accelerated rate of development (e.g., secondary spermatids appear well before metamorphic climax), a situation reported previously for other anuran species only in the genus Pseudis. These results, together with a skeletochronological analysis showing that some calling specimens presented no lines of arrested growth, indicate acceleration in the timing of sexual maturity in Pseudis, and raise questions about the interdependence/decoupling during the development of the different components involved in reaching the adult stage.

  3. Using Uncertainty Analysis to Guide the Development of Accelerated Stress Tests (Presentation)

    SciTech Connect

    Kempe, M.

    2014-03-01

    Extrapolation of accelerated testing to the long-term results expected in the field has uncertainty associated with the acceleration factors and the range of possible stresses in the field. When multiple stresses (such as temperature and humidity) can be used to increase the acceleration, the uncertainty may be reduced according to which stress factors are used to accelerate the degradation.

  4. Teacher Attitudes toward Subject-Specific Acceleration: Instrument Development and Validation

    ERIC Educational Resources Information Center

    Rambo, Karen E.; McCoach, D. Betsy

    2012-01-01

    Despite the research supporting acceleration, some teachers are still hesitant to recommend acceleration for advanced students. The Teacher Attitudes Toward Subject-Specific Acceleration (TATSSA) instrument was designed to uncover the factors that influence teacher decisions to recommend students for subject-specific acceleration. First, we…

  5. WInd-and-react Bi-2212 coil development for accelerator magnets

    SciTech Connect

    Godeke, A.; Acosta, P.; Cheng, D.; Dietderich, D. R.; Mentink, M. G. T.; Prestemon, S. O.; Meinesz, M.; Hong, S.; Huang, Y.; Miao, H.; Parrell, J.; Sabbi, G.L.

    2009-10-13

    Sub-scale coils are being manufactured and tested at Lawrence Berkeley National Laboratory in order to develop wind-and-react Bi{sub 2}Sr{sub 2}CaCu{sub 2}O{sub x} (Bi-2212) magnet technology for future graded accelerator magnet use. Previous Bi-2212 coils showed significant leakage of the conductors core constituents to the environment, which can occur during the partial melt reaction around 890 C in pure oxygen. The main origin of the observed leakage is intrinsic leakage of the wires, and the issue is therefore being addressed at the wire manufacturing level. We report on further compatibility studies, and the performance of new sub-scale coils that were manufactured using improved conductors. These coils exhibit significantly reduced leakage, and carry currents that are about 70% of the witness wire critical current (I{sub c}). The coils demonstrate, for the first time, the feasibility of round wire Bi-2212 conductors for accelerator magnet technology use. Successful high temperature superconductor coil technology will enable the manufacture of graded accelerator magnets that can surpass the, already closely approached, intrinsic magnetic field limitations of Nb-based superconducting magnets.

  6. Advanced laser particle accelerator development at LANL: from fast ignition to radiation oncology

    SciTech Connect

    Flippo, Kirk A; Gaillard, Sandrine A; Offermann, D T; Cobble, J A; Schmitt, M J; Gautier, D C; Kwan, T J T; Montgomery, D S; Kluge, Thomas; Bussmann, Micheal; Bartal, T; Beg, F N; Gall, B; Geissel, M; Korgan, G; Kovaleski, S; Lockard, T; Malekos, S; Schollmeier, M; Sentoku, Y; Cowan, T E

    2010-01-01

    Laser-plasma accelerated ion and electron beam sources are an emerging field with vast prospects, and promise many superior applications in a variety of fields such as hadron cancer therapy, compact radioisotope generation, table-top nuclear physics, laboratory astrophysics, nuclear forensics, waste transmutation, SN M detection, and inertial fusion energy. LANL is engaged in several projects seeking to develop compact high current and high energy ion and electron sources. We are especially interested in two specific applications: ion fast ignition/capsule perturbation and radiation oncology in conjunction with our partners at the ForschungsZentrum Dresden-Rossendorf (FZD). Laser-to-beam conversion efficiencies of over 10% are needed for practical applications, and we have already shown inherent etliciencies of >5% from flat foils, on Trident using only a 5th of the intensity and energy of the Nova Petawatt. With clever target designs, like structured curved cone targets, we have also been able to achieve major ion energy gains, leading to the highest energy laser-accelerated proton beams in the world. These new target designs promise to help usher in the next generation of particle sources realizing the potential of laser-accelerated beams.

  7. Vibration-Based Method Developed to Detect Cracks in Rotors During Acceleration Through Resonance

    NASA Technical Reports Server (NTRS)

    Sawicki, Jerzy T.; Baaklini, George Y.; Gyekenyesi, Andrew L.

    2004-01-01

    In recent years, there has been an increasing interest in developing rotating machinery shaft crack-detection methodologies and online techniques. Shaft crack problems present a significant safety and loss hazard in nearly every application of modern turbomachinery. In many cases, the rotors of modern machines are rapidly accelerated from rest to operating speed, to reduce the excessive vibrations at the critical speeds. The vibration monitoring during startup or shutdown has been receiving growing attention (ref. 1), especially for machines such as aircraft engines, which are subjected to frequent starts and stops, as well as high speeds and acceleration rates. It has been recognized that the presence of angular acceleration strongly affects the rotor's maximum response to unbalance and the speed at which it occurs. Unfortunately, conventional nondestructive evaluation (NDE) methods have unacceptable limits in terms of their application for online crack detection. Some of these techniques are time consuming and inconvenient for turbomachinery service testing. Almost all of these techniques require that the vicinity of the damage be known in advance, and they can provide only local information, with no indication of the structural strength at a component or system level. In addition, the effectiveness of these experimental techniques is affected by the high measurement noise levels existing in complex turbomachine structures. Therefore, the use of vibration monitoring along with vibration analysis has been receiving increasing attention.

  8. Accelerator production of tritium plant design and supporting engineering development and demonstration work

    SciTech Connect

    Lisowski, P.W.

    1997-11-01

    Tritium is an isotope of hydrogen with a half life of 12.3 years. Because it is essential for US thermonuclear weapons to function, tritium must be periodically replenished. Since K reactor at Savannah River Site stopped operating in 1988, tritium has been recycled from dismantled nuclear weapons. This process is possible only as long as many weapons are being retired. Maintaining the stockpile at the level called for in the present Strategic Arms Reduction Treaty (START-I) will require the Department of Energy to have an operational tritium production capability in the 2005--2007 time frame. To make the required amount of tritium using an accelerator based system (APT), neutrons will be produced through high energy proton reactions with tungsten and lead. Those neutrons will be moderated and captured in {sup 3}He to make tritium. The APT plant design will use a 1,700 MeV linear accelerator operated at 100 mA. In preparation for engineering design, starting in October 1997 and subsequent construction, a program of engineering development and demonstration is underway. That work includes assembly and testing of the first 20 MeV of the low energy plant linac at 100 mA, high-energy linac accelerating structure prototyping, radiofrequency power system improvements, neutronic efficiency measurements, and materials qualifications.

  9. Development of vacuum arc ion sources for heavy ion accelerator injectors and ion implantation technology (invited)

    NASA Astrophysics Data System (ADS)

    Oks, Efim M.

    1998-02-01

    The status of experimental research and ongoing development and upgrade of MEVVA-type ion sources over the last two years since the previous ICIS-95 is reviewed. There are two main application fields for this ion source: heavy ion accelerators and material surface implantation technology. For particle accelerator ion injection to accelerators it is important to enhance the fractions of multiply charged ions in the ion beam as well as controlling the charge state distribution, and to improve of beam current stability (i.e., to minimize the beam noise) and pulse-to-pulse reproducibility. For ion implantation application we need to increase both the implantation dose rate and the source lifetime (between required maintenance downtime) as well as making this kind of source more reliable and of yet low cost. Most of experimental results reported on here have been obtained in a collaborative program between research groups LBNL (Berkeley, USA), GSI (Darmstadt, Germany), HCEI (Tomsk, Russia), and other important contributions have been made by the groups at (BNU, Beijing, China), EDU (Izmir, Turkey), and elsewhere.

  10. Advanced Laser Particle Accelerator Development at LANL: From Fast Ignition to Radiation Oncology

    SciTech Connect

    Flippo, K. A.; Offermann, D. T.; Cobble, J. A.; Schmitt, M. J.; Gautier, D. C.; Kwan, T. J.; Montgomery, D. S.; Gaillard, S. A.; Kluge, T.; Bussmann, M.; Cowan, T. E.; Bartal, T.; Beg, F. N.; Gall, B.; Kovaleski, S.; Geissel, M.; Schollmeier, M.; Korgan, G.; Malekos, S.; Lockard, T.

    2010-11-04

    Laser-plasma accelerated ion and electron beam sources are an emerging field with vast prospects, and promise many superior applications in a variety of fields such as hadron cancer therapy, compact radioisotope generation, table-top nuclear physics, laboratory astrophysics, nuclear forensics, waste transmutation, Special Nuclear Material (SNM) detection, and inertial fusion energy. LANL is engaged in several projects seeking to develop compact high-current and high-energy ion and electron sources. We are especially interested in two specific applications: ion fast ignition/capsule perturbation and radiation oncology. Laser-to-beam conversion efficiencies of over 10% are needed for practical applications, and we have already shown inherent efficiencies of >5% from flat foils, on Trident using only a 5th of the intensity and energy of the Nova Petawatt laser. With clever target designs, like structured curved cone targets, we have also been able to achieve major ion energy gains, leading to the highest energy laser-accelerated proton beams in the world [3]. These new target designs promise to help usher in the next generation of particle sources realizing the potential of laser-accelerated beams.

  11. Physician's Breakout Session

    NASA Technical Reports Server (NTRS)

    Barry, William

    2001-01-01

    Dr. William Barry, Manager, NASA Occupational Health Program, moderated this session. As in one of the opening sessions, he re-iterated that the overall theme for the next year will be facilitating and implementing NIAT-1 (NASA Integrated Action Team - Action 1). He presented a candidate list of topics for consideration and discussion: (1) NIAT-1; (2) Skin cancer detection and the NASA Solar Safe Program; (3) Weapons of mass destruction; (4) Quality assurance; (5) Audits; (6) Environment of care; (7) Infection control; (8) Medication management; and (9) Confidentiality of medical records.

  12. Session on computation in biological pathways

    SciTech Connect

    Karp, P.D.; Riley, M.

    1996-12-31

    The papers in this session focus on the development of pathway databases and computational tools for pathway analysis. The discussion involves existing databases of sequenced genomes, as well as techniques for studying regulatory pathways.

  13. Breakthrough cancer medicine and its impact on novel drug development in China: report of the US Chinese Anti-Cancer Association (USCACA) and Chinese Society of Clinical Oncology (CSCO) Joint Session at the 17th CSCO Annual Meeting

    PubMed Central

    Luo, Feng Roger; Ding, Jian; Chen, Helen X.; Liu, Hao; Fung, Man-Cheong; Koehler, Maria; Armand, Jean Pierre; Jiang, Lei; Xu, Xiao; Zhang, Ge; Xu, Li; Qian, Pascal; Yan, Li

    2014-01-01

    The US Chinese Anti-Cancer Association (USCACA) teamed up with Chinese Society of Clinical Oncology (CSCO) to host a joint session at the17th CSCO Annual Meeting on September 20th, 2014 in Xiamen, China. With a focus on breakthrough cancer medicines, the session featured innovative approaches to evaluate breakthrough agents and established a platform to interactively share successful experiences from case studies of 6 novel agents from both the United States and China. The goal of the session is to inspire scientific and practical considerations for clinical trial design and strategy to expedite cancer drug development in China. A panel discussion further provided in-depth advice on advancing both early and full development of novel cancer medicines in China. PMID:25418191

  14. Neurovestibular Session Summary

    NASA Technical Reports Server (NTRS)

    Oman, Charles; Cohen, Malcolm

    1999-01-01

    Oman - The early mission operational problems caused by space motion sickness have been largely resolved in recent years. This has been achieved by appropriate timeline adjustments, voluntary head movement restriction, and judicious use of promethazine. Crew members now simply accept that some symptoms "come with the job," and usually last only a few days. But as more people have flown longer flights, we've seen cases of space sickness and inversion illusion that take several weeks to resolve. Visual reorientation illusions continue throughout long flights, and occasionally cause difficulties. EVA astronauts sometimes suddenly fear they will fall out of the payload bay or off of the RMS or Strella arms. Orientation and navigation in three dimensions in the MIR station reportedly does not come naturally, because modules have different visual verticals. It is clear that the neurovestibular problems of spaceflight have not disappeared. After return to Earth, many crew members are disoriented and ataxic in the first hour after return, and require assistance leaving the vehicle, Flight surgeons say that the longer the mission, the stronger the aftereffects, certain of which last for weeks. We do not yet know how to predict who will be afflicted. Looking ahead to 3-4 month long voyages to Mars, it seems obvious that if cruise is in O-G, the crew may encounter neurovestibular problems on arrival. Artificial G may be broadly effective as a countermeasure for many of the physiological changes of spaceflight, but from the neurovestibular perspective, it is a double-edged sword. We know that the Coriolis stimulus resulting from rotation is potentially disorienting and nauseogenic. But we don't yet know how much artificial G will be enough, nor how successfully people can adapt to a specific angular velocity and hypo G level. Development of countermeasures remains a big challenge for our neurovestibular community. Maintaining an interdisciplinary perspective is important

  15. Summary of Session III

    SciTech Connect

    Furman, M.A.

    2002-06-19

    This is a summary of the talks presented in Session III ''Simulations of Electron-Cloud Build Up'' of the Mini-Workshop on Electron-Cloud Simulations for Proton and Positron Beams ECLOUD-02, held at CERN, 15-18 April 2002.

  16. Abstracts of SIG Sessions.

    ERIC Educational Resources Information Center

    Proceedings of the ASIS Annual Meeting, 1994

    1994-01-01

    Includes abstracts of 18 special interest group (SIG) sessions. Highlights include natural language processing, information science and terminology science, classification, knowledge-intensive information systems, information value and ownership issues, economics and theories of information science, information retrieval interfaces, fuzzy thinking…

  17. Student Poster Sessions

    ERIC Educational Resources Information Center

    Baumgartner, Erin

    2004-01-01

    Poster presentations are one way scientists present their latest research findings at professional meetings. This format also works well in the classroom and gives students the opportunity to communicate the results of their experiments (perhaps the most critical portion of their studies). In a performance-based task such as a poster session,…

  18. The outreach sessions

    SciTech Connect

    Trache, Livius

    2015-02-24

    These are moderator’s remarks about the outreach day in the middle of the CSSP14, and in particular about the afternoon outreach session in round table format with the announced theme: “CERN at 60 and the internationalization of science”.

  19. Abstracts of SIG Sessions.

    ERIC Educational Resources Information Center

    Proceedings of the ASIS Annual Meeting, 1995

    1995-01-01

    Presents abstracts of 15 special interest group (SIG) sessions. Topics include navigation and information utilization in the Internet, natural language processing, automatic indexing, image indexing, classification, users' models of database searching, online public access catalogs, education for information professions, information services,…

  20. UCLA accelerator research and development. Progress report, [November 1, 1991--July 31, 1992

    SciTech Connect

    Cline, D.B.

    1992-09-01

    This progress report covers work supported by the above DOE grant over the period November 1, 1991 to July 31, 1992. The work is a program of experimental and theoretical studies in advanced particle accelerator research and development for high energy physics applications. The program features research at particle beam facilities in the United States and includes research on novel high power sources, novel focussing systems (e.g. plasma lens), beam monitors, novel high brightness, high current gun systems, and novel flavor factories in particular the {phi} Factory.

  1. Niobium cavity development for the high-energy linac of the rare isotope accelerator

    SciTech Connect

    D. Barni; C. Pagani; P. Pierini; C. Compton; T. Grimm; W. Hartung; H. Podlech; R. York; G. Ciovati; P. Kneisel

    2001-08-01

    The Rare Isotope Accelerator (RIA) is being designed to supply an intense beam of exotic isotopes for nuclear physics research [1]. Superconducting cavities are to be used to accelerate the CW beam of heavy ions to 400 MeV per nucleon, with a beam power of up to 400 kW. Because of the varying velocity of the ion beam along the linac, a number of different types of superconducting structures are needed. The RIA linac will accelerate heavy ions over the same velocity range as the proton linac for the Spallation Neutron Source (SNS). It was decided to use the 6-cell axisymmetric 805 MHz cavities and cryostats of SNS for the downstream portion of the RIA linac, thereby saving the non-recurring development and engineering costs. For additional cost saving, it was decided to extend the SNS multi-cell axisymmetric cavity design to lower velocity, {beta} = v/c = 0.4, using the same cryostats and RF systems. Axisymmetric cavities will thus constitute about three-quarters of RIA's total accelerating voltage, and most of that voltage will be provided by cavities already developed for SNS. The axisymmetric cavities will accelerate the RIA beam from {beta} = 0.4 to {beta} = 0.72. This velocity range can be efficiently covered with two different types of 6-cell cavities, one with a geometric {beta}, {beta}{sub g}, of 0.47, and the other with a {beta}{sub g} of 0.61. The {beta}{sub g} = 0.61 cavity will be of the existing SNS design; some {beta}{sub g} = 0.81 SNS cavities may also be desired at the end of the RIA linac for acceleration of light ions above 400 MeV per nucleon. Prototypes for both {beta}{sub g} = 0.61 and {beta}{sub g} = 0.81 have been fabricated and tested [2]. The {beta}{sub g} = 0.47 cavity is the focus of the present work. The reduction in {beta}{sub g} to 0.47 results in less favourable electromagnetic and mechanical properties, and opens up the possibility of multipacting, but several groups have already designed and prototyped cavities in this range. These

  2. Neoadjuvant paradigm for accelerated drug development: an ideal model in bladder cancer.

    PubMed

    Chism, David D; Woods, Michael E; Milowsky, Matthew I

    2013-01-01

    Neoadjuvant cisplatin-based combination chemotherapy for muscle-invasive bladder cancer (MIBC) has been shown to confer a survival advantage in two randomized clinical trials and a meta-analysis. Despite level 1 evidence supporting its benefit, utilization remains dismal with nearly one-half of patients ineligible for cisplatin-based therapy because of renal dysfunction, impaired performance status, and/or coexisting medical problems. This situation highlights the need for the development of novel therapies for the management of MIBC, a disease with a lethal phenotype. The neoadjuvant paradigm in bladder cancer offers many advantages for accelerated drug development. First, there is a greater likelihood of successful therapy at an earlier disease state that may be characterized by less genomic instability compared with the metastatic setting, with an early readout of activity with results determined in months rather than years. Second, pre- and post-treatment tumor tissue collection in patients with MIBC is performed as the standard of care without the need for research-directed biopsies, allowing for the ability to perform important correlative studies and to monitor tumor response to therapy in "real time." Third, pathological complete response (pT0) predicts for improved outcome in patients with MIBC. Fourth, there is a strong biological rationale with rapidly accumulating evidence for actionable targets in bladder cancer. This review focuses on the neoadjuvant paradigm for accelerated drug development using bladder cancer as the ideal model.

  3. Active involvement of learning disabilities service users in the development and delivery of a teaching session to pre-registration nurses: Students' perspectives.

    PubMed

    Smith, Penny; Ooms, Ann; Marks-Maran, Di

    2016-01-01

    A teaching session about service users' experiences of accessing and receiving health and social care was designed and delivered by service users to first year BSc Nursing students. The aim was to enhance students' knowledge, skills and confidence in caring for people with a learning disability. An evaluation research study was undertaking at one university in London into the perceived effectiveness of the teaching session, including students' perceptions of the extent to which the service users' teaching session was useful, the impact of the session, its benefits and challenges and the sustainability of teaching sessions delivered by service users. Data were collected through an online questionnaire. Quantitative analysis was undertaken of Likert-style questions and qualitative analysis was undertaken using the Framework Method. The session impacted on students' knowledge and understanding of people with a learning disability. Students reported that they felt more comfortable and confident interacting with people with a learning disability. In addition, they reflected on their feelings about caring for people with a learning disability.

  4. Not all stressors are equal: behavioral and endocrine evidence for development of contextual fear conditioning after a single session of footshocks but not of immobilization

    PubMed Central

    Daviu, Núria; Delgado-Morales, Raúl; Nadal, Roser; Armario, Antonio

    2012-01-01

    Exposure of animals to footshocks (FS) in absence of any specific cue results in the development of fear to the compartment where shocks were given (contextual fear conditioning), and this is usually evaluated by time spent freezing. However, the extent to which contextual fear conditioning always develops when animals are exposed to other stressors is not known. In the present work we firstly demonstrated, using freezing, that exposure of adult rats to a single session of FS resulted in short-term and long-term contextual fear conditioning (freezing) that was paralleled by increased hypothalamic-pituitary-adrenal (HPA) activation. In contrast, using a similar design, no HPA or behavioral evidence for such conditioning was found after exposure to immobilization on boards (IMO), despite this stressor being of similar severity as FS on the basis of standard physiological measures of stress, including HPA activation. In a final experiment we directly compared the exposure to the two stressors in the same type of context and tested for the development of conditioning to the context and to a specific cue for IMO (the board). We observed the expected high levels of freezing and the conditioned HPA activation after FS, but not after IMO, regardless of the presence of the board during testing. Therefore, it can be concluded that development of fear conditioning to context or particular cues, as evaluated by either behavioral or endocrine measures, appears to be dependent on the nature of the aversive stimuli, likely to be related to biologically preparedness to establish specific associations. PMID:23112767

  5. Surface water geochemical and isotopic variations in an area of accelerating Marcellus Shale gas development.

    PubMed

    Pelak, Adam J; Sharma, Shikha

    2014-12-01

    Water samples were collected from 50 streams in an area of accelerating shale gas development in the eastern U.S.A. The geochemical/isotopic characteristics show no correlation with the five categories of Marcellus Shale production. The sub-watersheds with the greatest density of Marcellus Shale development have also undergone extensive coal mining. Hence, geochemical/isotopic compositions were used to understand sources of salinity and effects of coal mining and shale gas development in the area. The data indicates that while some streams appear to be impacted by mine drainage; none appear to have received sustained contribution from deep brines or produced waters associated with shale gas production. However, it is important to note that our interpretations are based on one time synoptic base flow sampling of a few sampling stations and hence do account potential intermittent changes in chemistry that may result from major/minor spills or specific mine discharges on the surface water chemistry.

  6. Development of an accelerated leach test(s) for low-level waste forms

    SciTech Connect

    Dougherty, D.R.; Fuhrmann, M.; Colombo, P.

    1985-01-01

    An accelerated leach test(s) is being developed to predict long-term leaching behavior of low-level radioactive waste (LLW) forms in their disposal environments. As necessary background, a literature survey of reported leaching mechanisms, available mathematical models and factors that affect leaching of LLW forms has been compiled. Mechanisms which have been identified include diffusion, dissolution, ion exchange, corrosion and surface effects. A computerized data base of LLW leaching data and mathematical models is being developed. The data is being used for model evaluation by curve fitting and statistical analysis according to standard procedures of statistical quality control. Long-term leach tests on portland cement, bitumen and vinyl ester-styrene (VES) polymer waste forms are underway which are designed to identify and evaluate factors that accelerate leaching without changing the mechanisms. Initial results on the effect of temperature on leachability indicate that the leach rates of cement and VES waste forms increase with increasing temperature, whereas, the leach rate of bitumen is little affected. 10 refs., 5 figs.

  7. Neutron research and facility development at the Oak Ridge Electron Linear Accelerator 1970 to 1995

    SciTech Connect

    Peelle, R.W.; Harvey, J.A.; Maienschein, F.C.; Weston, L.W.; Olsen, D.K.; Larson, D.C.; Macklin, R.L.

    1982-07-01

    This report reviews the accomplishments of the first decade of operation of the Oak Ridge Electron Linear Accelerator (ORELA) and discusses the plans for the facility in the coming decade. Motivations for scientific and applied research during the next decade are included. In addition, ORELA is compared with competing facilities, and prospects for ORELA's improvement and even replacement are reported. Development efforts for the next few years are outlined that are consistent with the anticipated research goals. Recommendations for hardware development include improving the electron injection system to give much larger short-pulse currents on a reliable basis, constructing an Electron Beam Injector Laboratory to help make this improvement possible, continuing a study of possibly replacing the electron accelerator with a proton machine, and replacing or upgrading the facility's data-acquistion and immediate-analysis computer systems. Increased operating time and more involvement of nuclear theorists are recommended, and an effective staff size for optimum use of this unique facility is discussed. A bibliography of all ORELA-related publications is included.

  8. Effects of Prenatal Irradiation with an Accelerated Heavy-Ion Beam on Postnatal Development in Rats

    NASA Astrophysics Data System (ADS)

    Wang, B.; Murakami, M.; Eguchi-Kasai, K.; Nojima, K.; Shang, Y.; Tanaka, K.; Fujita, K.; Coffigny, H.; Hayata, I.

    Effects on postnatal neurophysiological development in offspring were studied following exposure of pregnant Wistar rats to accelerated neon-ion beams with a LET value of about 30 keV mu m at a dose range from 0 1 Gy to 2 0Gy on the 15th day of gestation The age at which four physiologic markers appeared and five reflexes were acquired was examined prior to weaning Gain in body weight was monitored until the offspring were 3 months old Male offspring were evaluated as young adults using two behavioral tests The effects of X-rays at 200 kVp measured for the same biological end points were studied for comparison Our previous study on carbon-ion beams with a LET value of about 13 keV mu m was also cited to elucidate a possible LET-related effect For most of the endpoints at early age significant alteration was even observed in offspring prenatally received 0 1 Gy of accelerated neon ions while neither X rays nor carbon-ions under the same dose resulted in such a significant alteration compared to that from the sham-irradiated dams All offspring whose mothers received 2 0 Gy died prior to weaning Offspring from dams irradiated with accelerated neon ions generally showed higher incidences of prenatal death and preweaning mortality markedly delayed accomplishment in their physiological markers and reflexes and gain in body weight compared to those exposed to X-rays or carbon ions at doses of 0 1 to 1 5 Gy Significantly reduced ratios of main organ weight to body weight at postnatal ages of 30 60 and 90 days were also observed

  9. High Voltage Hall Accelerator Propulsion System Development for NASA Science Missions

    NASA Technical Reports Server (NTRS)

    Kamhawi, Hani; Haag, Thomas; Huang, Wensheng; Shastry, Rohit; Pinero, Luis; Peterson, Todd; Dankanich, John; Mathers, Alex

    2013-01-01

    NASA Science Mission Directorates In-Space Propulsion Technology Program is sponsoring the development of a 3.8 kW-class engineering development unit Hall thruster for implementation in NASA science and exploration missions. NASA Glenn Research Center and Aerojet are developing a high fidelity high voltage Hall accelerator (HiVHAc) thruster that can achieve specific impulse magnitudes greater than 2,700 seconds and xenon throughput capability in excess of 300 kilograms. Performance, plume mappings, thermal characterization, and vibration tests of the HiVHAc engineering development unit thruster have been performed. In addition, the HiVHAc project is also pursuing the development of a power processing unit (PPU) and xenon feed system (XFS) for integration with the HiVHAc engineering development unit thruster. Colorado Power Electronics and NASA Glenn Research Center have tested a brassboard PPU for more than 1,500 hours in a vacuum environment, and a new brassboard and engineering model PPU units are under development. VACCO Industries developed a xenon flow control module which has undergone qualification testing and will be integrated with the HiVHAc thruster extended duration tests. Finally, recent mission studies have shown that the HiVHAc propulsion system has sufficient performance for four Discovery- and two New Frontiers-class NASA design reference missions.

  10. Session: Reservoir Technology

    SciTech Connect

    Renner, Joel L.; Bodvarsson, Gudmundur S.; Wannamaker, Philip E.; Horne, Roland N.; Shook, G. Michael

    1992-01-01

    This session at the Geothermal Energy Program Review X: Geothermal Energy and the Utility Market consisted of five papers: ''Reservoir Technology'' by Joel L. Renner; ''LBL Research on the Geysers: Conceptual Models, Simulation and Monitoring Studies'' by Gudmundur S. Bodvarsson; ''Geothermal Geophysical Research in Electrical Methods at UURI'' by Philip E. Wannamaker; ''Optimizing Reinjection Strategy at Palinpinon, Philippines Based on Chloride Data'' by Roland N. Horne; ''TETRAD Reservoir Simulation'' by G. Michael Shook

  11. Session: Energy Conversion

    SciTech Connect

    Robertson, David; LaSala, Raymond J.; Kukacka, Lawrence E.; Bliem, Carl J.; Premuzic, Eugene T.; Weare, John H.

    1992-01-01

    This session at the Geothermal Energy Program Review X: Geothermal Energy and the Utility Market consisted of five presentations: ''Hydrothermal Energy Conversion Technology'' by David Robertson and Raymond J. LaSala; ''Materials for Geothermal Production'' by Lawrence E. Kukacka; ''Supersaturated Turbine Expansions for Binary Geothermal Power Plants'' by Carl J. Bliem; ''Geothermal Waster Treatment Biotechnology: Progress and Advantages to the Utilities'' by Eugen T. Premuzic; and ''Geothermal Brine Chemistry Modeling Program'' by John H. Weare.

  12. Accelerating Development of EV Batteries Through Computer-Aided Engineering (Presentation)

    SciTech Connect

    Pesaran, A.; Kim, G. H.; Smith, K.; Santhanagopalan, S.

    2012-12-01

    The Department of Energy's Vehicle Technology Program has launched the Computer-Aided Engineering for Automotive Batteries (CAEBAT) project to work with national labs, industry and software venders to develop sophisticated software. As coordinator, NREL has teamed with a number of companies to help improve and accelerate battery design and production. This presentation provides an overview of CAEBAT, including its predictive computer simulation of Li-ion batteries known as the Multi-Scale Multi-Dimensional (MSMD) model framework. MSMD's modular, flexible architecture connects the physics of battery charge/discharge processes, thermal control, safety and reliability in a computationally efficient manner. This allows independent development of submodels at the cell and pack levels.

  13. Preparative Scale Resolution of Enantiomers Enables Accelerated Drug Discovery and Development.

    PubMed

    Leek, Hanna; Andersson, Shalini

    2017-01-18

    The provision of pure enantiomers is of increasing importance not only for the pharmaceutical industry but also for agro-chemistry and biotechnology. In drug discovery and development, the enantiomers of a chiral drug depict unique chemical and pharmacological behaviors in a chiral environment, such as the human body, in which the stereochemistry of the chiral drugs determines their pharmacokinetic, pharmacodynamic and toxicological properties. We present a number of challenging case studies of up-to-kilogram separations of racemic or enriched isomer mixtures using preparative liquid chromatography and super critical fluid chromatography to generate individual enantiomers that have enabled the development of new candidate drugs within AstraZeneca. The combination of chromatography and racemization as well as strategies on when to apply preparative chiral chromatography of enantiomers in a multi-step synthesis of a drug compound can further facilitate accelerated drug discovery and the early clinical evaluation of the drug candidates.

  14. Development and construction of a neutron beam line for accelerator-based boron neutron capture synovectomy.

    PubMed

    Gierga, D P; Yanch, J C; Shefer, R E

    2000-01-01

    A potential application of the 10B(n, alpha)7Li nuclear reaction for the treatment of rheumatoid arthritis, termed Boron Neutron Capture Synovectomy (BNCS), is under investigation. In an arthritic joint, the synovial lining becomes inflamed and is a source of great pain and discomfort for the afflicted patient. The goal of BNCS is to ablate the synovium, thereby eliminating the symptoms of the arthritis. A BNCS treatment would consist of an intra-articular injection of boron followed by neutron irradiation of the joint. Monte Carlo radiation transport calculations have been used to develop an accelerator-based epithermal neutron beam line for BNCS treatments. The model includes a moderator/reflector assembly, neutron producing target, target cooling system, and arthritic joint phantom. Single and parallel opposed beam irradiations have been modeled for the human knee, human finger, and rabbit knee joints. Additional reflectors, placed to the side and back of the joint, have been added to the model and have been shown to improve treatment times and skin doses by about a factor of 2. Several neutron-producing charged particle reactions have been examined for BNCS, including the 9Be(p,n) reaction at proton energies of 4 and 3.7 MeV, the 9Be(d,n) reaction at deuteron energies of 1.5 and 2.6 MeV, and the 7Li(p,n) reaction at a proton energy of 2.5 MeV. For an accelerator beam current of 1 mA and synovial boron uptake of 1000 ppm, the time to deliver a therapy dose of 10,000 RBEcGy ranges from 3 to 48 min, depending on the treated joint and the neutron producing charged particle reaction. The whole-body effective dose that a human would incur during a knee treatment has been estimated to be 3.6 rem or 0.75 rem, for 1000 ppm or 19,000 ppm synovial boron uptake, respectively, although the shielding configuration has not yet been optimized. The Monte Carlo design process culminated in the construction, installation, and testing of a dedicated BNCS beam line on the high

  15. Development of a PYTHON-based emittance calculator at Fermilab Accelerator Science and Technology (FAST) facility

    NASA Astrophysics Data System (ADS)

    Green, A. T.

    Beam emittance is an important characteristic describing charged particle beams. In linear accelerators (linac), it is critical to characterize the beam phase space parameters and, in particular, to precisely measure transverse beam emittance. The quadrupole scan (quad-scan) is a well-established technique used to characterize transverse beam parameters in four-dimensional phase space, including beam emittance. A computational algorithm with PYTHON scripts has been developed to estimate beam parameters, in particular beam emittance, using the quad-scan technique in the electron linac at the Fermilab Accelerator Science and Technology (FAST) facility. This script has been implemented in conjunction with an automated quad-scan tool (also written in PYTHON) and has decreased the time it takes to perform a single quad-scan from an hour to a few minutes. From the experimental data, the emittance calculator quickly delivers several results including: geometrical and normalized transverse emittance, Courant-Snyder parameters, and plots of the beam size versus quadrupole field strength, among others. This paper will discuss the details of the techniques used, the results from several quad-scans preformed at FAST during the electron injector commissioning, and the PYTHON code used to obtain the results.

  16. The development of seismic guidelines for the Stanford Linear Accelerator Center

    SciTech Connect

    Huggins, R.

    1996-08-01

    This paper describes the development of Seismic Guidelines for the Stanford Linear Accelerator Center (SLAC). Although structures have always been built conservatively, SLAC management decided to review and update their seismic guidelines. SLAC is about mid-way between the epicenters of the 8.3 Richter magnitude 1906 San Francisco and the 7.2 Loma Prieta Earthquakes. The west end of the two mile long electron/positron particle accelerator lies a half mile from the large San Andreas Fault. Suggestions for seismic planning processes were solicited from local computer manufacturing firms, universities, and federal laboratories. A Committee of the various stakeholders in SLAC`s seismic planning retained an internationally known Seismic Planning Consultant and reviewed relevant standards and drafted Guidelines. A panel of seismic experts was convened to help define the hazard, site response spectra, probabilistic analysis of shaking, and near field effects. The Facility`s structures were assigned to seismic classes of importance, and an initial assessment of a sample of a dozen buildings conducted. This assessment resulted in emergency repairs to one structure, and provided a {open_quotes}reality basis{close_quotes} for establishing the final Guidelines and Administrative Procedures, and a program to evaluate remaining buildings, shielding walls, tunnels, and other special structures.

  17. Development of a dual-layered dielectric-loaded accelerating structure

    NASA Astrophysics Data System (ADS)

    Jing, Chunguang; Kanareykin, Alexei; Kazakov, Sergey; Liu, Wanming; Nenasheva, Elizaveta; Schoessow, Paul; Gai, Wei

    2008-09-01

    rf Power attenuation is a critical problem in the development of dielectric-loaded structures for particle acceleration. In a previous paper [C. Jing, W. Liu, W. Gai, J. Power, T. Wong, Nucl. Instr. Meth. A 539 (2005) 445] we suggested the use of a Multilayer Dielectric-Loaded Accelerating Structure (MDLA) as a possible approach for reducing the rf losses in a single layer device. The MDLA is based on the principle of Bragg reflection familiar from optics that is used to partially confine the fields inside the dielectric layers and reduce the wall current losses at the outer boundary. We report here on the design, construction and testing of a prototype X-band double-layer structure (2DLA). The measurements show an rf power attenuation for the 2DLA more than ten times smaller than that of a comparable single-layer structure, in good agreement with the analytic results. Testing and operation of MDLAs also requires efficient power coupling from test equipment or rf power systems to the device. We describe the design and construction of two novel structures: a TM 03 mode launcher for cold testing and a power coupler for planned high-gradient experiments.

  18. Recent advances in the development of high average power induction accelerators for industrial and environmental applications

    SciTech Connect

    Neau, E.L.

    1994-09-01

    Short-pulse accelerator technology developed during the early 1960`s through the late 1980`s is being extended to high average power systems capable of use in industrial and environmental applications. Processes requiring high dose levels and/or high volume throughput will require systems with beam power levels from several hundreds of kilowatts to megawatts. Beam accelerating potentials can range from less than 1 MeV to as much as 10 MeV depending on the type of beam, depth of penetration required, and the density of the product being treated. This paper addresses the present status of a family of high average power systems, with output beam power levels up to 200 kW, now in operation that use saturable core switches to achieve output pulse widths of 50 to 80 nanoseconds. Inductive adders and field emission cathodes are used to generate beams of electrons or x-rays at up to 2.5 MeV over areas of 1000 cm{sup 2}. Similar high average power technology is being used at {le} 1 MeV to drive repetitive ion beam sources for treatment of material surfaces over 100`s of cm{sup 2}.

  19. Development of Velocity Guidance Assistance System by Haptic Accelerator Pedal Reaction Force Control

    NASA Astrophysics Data System (ADS)

    Yin, Feilong; Hayashi, Ryuzo; Raksincharoensak, Pongsathorn; Nagai, Masao

    This research proposes a haptic velocity guidance assistance system for realizing eco-driving as well as enhancing traffic capacity by cooperating with ITS (Intelligent Transportation Systems). The proposed guidance system generates the desired accelerator pedal (abbreviated as pedal) stroke with respect to the desired velocity obtained from ITS considering vehicle dynamics, and provides the desired pedal stroke to the driver via a haptic pedal whose reaction force is controllable and guides the driver in order to trace the desired velocity in real time. The main purpose of this paper is to discuss the feasibility of the haptic velocity guidance. A haptic velocity guidance system for research is developed on the Driving Simulator of TUAT (DS), by attaching a low-inertia, low-friction motor to the pedal, which does not change the original characteristics of the original pedal when it is not operated, implementing an algorithm regarding the desired pedal stroke calculation and the reaction force controller. The haptic guidance maneuver is designed based on human pedal stepping experiments. A simple velocity profile with acceleration, deceleration and cruising is synthesized according to naturalistic driving for testing the proposed system. The experiment result of 9 drivers shows that the haptic guidance provides high accuracy and quick response in velocity tracking. These results prove that the haptic guidance is a promising velocity guidance method from the viewpoint of HMI (Human Machine Interface).

  20. Status of engineering development of CCDTL for accelerator production of tritium

    SciTech Connect

    Wood, R.L.; Billen, J.H.; Hunter, W.T.; Leslie, P.O.; Roybal, R.J.; Sigler, F.E.

    1998-12-31

    The Coupled-Cavity Drift Tube Linac (CCDTL) is a relatively new RF accelerator structure which plays a major role in the APT Low-Energy Linac (LEL) design. Engineering development is pushing ahead on several fronts, including thermal management, fabrication procedures, cavity and coupling slot tuning, high-power prototype fabrication and testing, supports and alignment, vacuum, and provisions for beam diagnostics. Fabrication of the CCDTL Low-Beta Hot Model is nearly complete, and high-power RF tests will commence soon. In 1999, the authors will begin the fabrication of 11 meters of CCDTL to be added to the Low-Energy Demonstration Accelerator. In 2001, it will take the 100 mA beam from 6.7 MeV to 10.05 MeV, producing the world`s most powerful proton beam. The authors are also starting the design of a CCDTL 96 MeV Hot Model to demonstrate cooling of an intermediate-Beta version of the structure. The 14cm-long, 9cm diameter drift tube has roughly 5kW dissipated on it. This all leads to the final mechanical design of the 113m long CCDTL for the APT plant linac.

  1. New options for developing of nuclear energy using an accelerator-driven reactor

    SciTech Connect

    Takahashi, Hiroshi

    1997-09-01

    Fissile fuel can be produced at a high rate using an accelerator-driven Pu-fueled subcritical fast reactor. Thus, the necessity of early introduction of the fast reactor can be moderated. High reliability of the proton accelerator, which is essential to implementing an accelerator-driven reactor in the nuclear energy field can be achieved by a slight extension of the accelerator`s length, with only a small economical penalty. Subcritical operation provides flexible nuclear energy options including high neutron economy producing the fuel, transmuting high-level wastes, such as minor actinides, and of converting efficiently the excess Pu and military Pu into proliferation-resistant fuel.

  2. 98th LHCC meeting Agenda OPEN Session and CLOSED Session

    ScienceCinema

    None

    2016-07-12

    OPEN Session on Wednesday, 8 July at 9h00-11h00 in Main Auditorium, Live webcast, followed by CLOSED Session, Conference room 160-1-009 11h20-17h00. CLOSED Session continued on Thursday, 9 July at 9h00-12h30

  3. Analytical Validation of Accelerator Mass Spectrometry for Pharmaceutical Development: the Measurement of Carbon-14 Isotope Ratio.

    SciTech Connect

    Keck, B D; Ognibene, T; Vogel, J S

    2010-02-05

    Accelerator mass spectrometry (AMS) is an isotope based measurement technology that utilizes carbon-14 labeled compounds in the pharmaceutical development process to measure compounds at very low concentrations, empowers microdosing as an investigational tool, and extends the utility of {sup 14}C labeled compounds to dramatically lower levels. It is a form of isotope ratio mass spectrometry that can provide either measurements of total compound equivalents or, when coupled to separation technology such as chromatography, quantitation of specific compounds. The properties of AMS as a measurement technique are investigated here, and the parameters of method validation are shown. AMS, independent of any separation technique to which it may be coupled, is shown to be accurate, linear, precise, and robust. As the sensitivity and universality of AMS is constantly being explored and expanded, this work underpins many areas of pharmaceutical development including drug metabolism as well as absorption, distribution and excretion of pharmaceutical compounds as a fundamental step in drug development. The validation parameters for pharmaceutical analyses were examined for the accelerator mass spectrometry measurement of {sup 14}C/C ratio, independent of chemical separation procedures. The isotope ratio measurement was specific (owing to the {sup 14}C label), stable across samples storage conditions for at least one year, linear over 4 orders of magnitude with an analytical range from one tenth Modern to at least 2000 Modern (instrument specific). Further, accuracy was excellent between 1 and 3 percent while precision expressed as coefficient of variation is between 1 and 6% determined primarily by radiocarbon content and the time spent analyzing a sample. Sensitivity, expressed as LOD and LLOQ was 1 and 10 attomoles of carbon-14 (which can be expressed as compound equivalents) and for a typical small molecule labeled at 10% incorporated with {sup 14}C corresponds to 30 fg

  4. Residual acceleration data on IML-1: Development of a data reduction and dissemination plan

    NASA Technical Reports Server (NTRS)

    Rogers, Melissa J. B.; Alexander, J. Iwan D.; Wolf, Randy

    1992-01-01

    The need to record some measure of the low-gravity environment of an orbiting space vehicle was recognized at an early stage of the U.S. Space Program. Such information was considered important for both the assessment of an astronaut's physical condition during and after space missions and the analysis of the fluid physics, materials processing, and biological sciences experiments run in space. Various measurement systems were developed and flown on space platforms beginning in the early 1970's. Similar in concept to land based seismometers that measure vibrations caused by earthquakes and explosions, accelerometers mounted on orbiting space vehicles measure vibrations in and of the vehicle due to internal and external sources, as well as vibrations in a sensor's relative acceleration with respect to the vehicle to which it is attached. The data collected over the years have helped to alter the perception of gravity on-board a space vehicle from the public's early concept of zero-gravity to the science community's evolution of thought from microgravity to milligravity to g-jitter or vibrational environment. Since the advent of the Shuttle Orbiter Program, especially since the start of Spacelab flights dedicated to scientific investigations, the interest in measuring the low-gravity environment in which experiments are run has increased. This interest led to the development and flight of numerous accelerometer systems dedicated to specific experiments. It also prompted the development of the NASA MSAD-sponsored Space Acceleration Measurement System (SAMS). The first SAMS units flew in the Spacelab on STS-40 in June 1991 in support of the first Spacelab Life Sciences mission (SLS-1). SAMS is currently manifested to fly on all future Spacelab missions.

  5. Residual acceleration data on IML-1: Development of a data reduction and dissemination plan

    NASA Astrophysics Data System (ADS)

    Rogers, Melissa J. B.; Alexander, J. Iwan D.; Wolf, Randy

    1992-09-01

    The need to record some measure of the low-gravity environment of an orbiting space vehicle was recognized at an early stage of the U.S. Space Program. Such information was considered important for both the assessment of an astronaut's physical condition during and after space missions and the analysis of the fluid physics, materials processing, and biological sciences experiments run in space. Various measurement systems were developed and flown on space platforms beginning in the early 1970's. Similar in concept to land based seismometers that measure vibrations caused by earthquakes and explosions, accelerometers mounted on orbiting space vehicles measure vibrations in and of the vehicle due to internal and external sources, as well as vibrations in a sensor's relative acceleration with respect to the vehicle to which it is attached. The data collected over the years have helped to alter the perception of gravity on-board a space vehicle from the public's early concept of zero-gravity to the science community's evolution of thought from microgravity to milligravity to g-jitter or vibrational environment. Since the advent of the Shuttle Orbiter Program, especially since the start of Spacelab flights dedicated to scientific investigations, the interest in measuring the low-gravity environment in which experiments are run has increased. This interest led to the development and flight of numerous accelerometer systems dedicated to specific experiments. It also prompted the development of the NASA MSAD-sponsored Space Acceleration Measurement System (SAMS). The first SAMS units flew in the Spacelab on STS-40 in June 1991 in support of the first Spacelab Life Sciences mission (SLS-1). SAMS is currently manifested to fly on all future Spacelab missions.

  6. Accelerated development of Zr-containing new generation ferritic steels for advanced nuclear reactors

    SciTech Connect

    Tan, Lizhen; Yang, Ying; Sridharan, K.

    2015-12-01

    The mission of the Nuclear Energy Enabling Technologies (NEET) program is to develop crosscutting technologies for nuclear energy applications. Advanced structural materials with superior performance at elevated temperatures are always desired for nuclear reactors, which can improve reactor economics, safety margins, and design flexibility. They benefit not only new reactors, including advanced light water reactors (LWRs) and fast reactors such as the sodium-cooled fast reactor (SFR) that is primarily designed for management of high-level wastes, but also life extension of the existing fleet when component exchange is needed. Developing and utilizing the modern materials science tools (experimental, theoretical, and computational tools) is an important path to more efficient alloy development and process optimization. The ultimate goal of this project is, with the aid of computational modeling tools, to accelerate the development of Zr-bearing ferritic alloys that can be fabricated using conventional steelmaking methods. The new alloys are expected to have superior high-temperature creep performance and excellent radiation resistance as compared to Grade 91. The designed alloys were fabricated using arc-melting and drop-casting, followed by hot rolling and conventional heat treatments. Comprehensive experimental studies have been conducted on the developed alloys to evaluate their hardness, tensile properties, creep resistance, Charpy impact toughness, and aging resistance, as well as resistance to proton and heavy ion (Fe2+) irradiation.

  7. Narrow bandwidth Thomson photon source development using Laser-Plasma Accelerators

    NASA Astrophysics Data System (ADS)

    Geddes, C. G. R.; van Tilborg, J.; Tsai, H.-E.; Toth, Cs.; Vay, J.-L.; Lehe, R.; Schroeder, C. B.; Esarey, E.; Rykovanov, S. G.; Grote, D. P.; Friedman, A.; Leemans, W. P.

    2016-10-01

    Compact, high-quality photon sources at MeV energies are being developed based on Laser-Plasma Accelerators (LPAs). An independent scattering laser with controlled pulse shaping in frequency and amplitude can be used together with laser guiding to realize high photon yield and narrow bandwidth. Simulations are presented on production of controllable narrow bandwidth sources using the beam and plasma capabilities of LPAs. Recent experiments and simulations demonstrate controllable LPAs in the energy range appropriate to MeV Thomson sources. Design of experiments and laser capabilities to combine these elements will be presented, towards a compact photon source system. A dedicated facility under construction will be described. Work supported by US DOE NNSA DNN R&D and by Sc. HEP under contract DE-AC02-05CH11231.

  8. Accelerated renal disease is associated with the development of metabolic syndrome in a glucolipotoxic mouse model

    PubMed Central

    Martínez-García, Cristina; Izquierdo, Adriana; Velagapudi, Vidya; Vivas, Yurena; Velasco, Ismael; Campbell, Mark; Burling, Keith; Cava, Fernando; Ros, Manuel; Orešič, Matej; Vidal-Puig, Antonio; Medina-Gomez, Gema

    2012-01-01

    SUMMARY Individuals with metabolic syndrome are at high risk of developing chronic kidney disease (CKD) through unclear pathogenic mechanisms. Obesity and diabetes are known to induce glucolipotoxic effects in metabolically relevant organs. However, the pathogenic role of glucolipotoxicity in the aetiology of diabetic nephropathy is debated. We generated a murine model, the POKO mouse, obtained by crossing the peroxisome proliferator-activated receptor gamma 2 (PPARγ2) knockout (KO) mouse into a genetically obese ob/ob background. We have previously shown that the POKO mice showed: hyperphagia, insulin resistance, hyperglycaemia and dyslipidaemia as early as 4 weeks of age, and developed a complete loss of normal β-cell function by 16 weeks of age. Metabolic phenotyping of the POKO model has led to investigation of the structural and functional changes in the kidney and changes in blood pressure in these mice. Here we demonstrate that the POKO mouse is a model of renal disease that is accelerated by high levels of glucose and lipid accumulation. Similar to ob/ob mice, at 4 weeks of age these animals exhibited an increased urinary albumin:creatinine ratio and significantly increased blood pressure, but in contrast showed a significant increase in the renal hypertrophy index and an associated increase in p27Kip1 expression compared with their obese littermates. Moreover, at 4 weeks of age POKO mice showed insulin resistance, an alteration of lipid metabolism and glomeruli damage associated with increased transforming growth factor beta (TGFβ) and parathyroid hormone-related protein (PTHrP) expression. At this age, levels of proinflammatory molecules, such as monocyte chemoattractant protein-1 (MCP-1), and fibrotic factors were also increased at the glomerular level compared with levels in ob/ob mice. At 12 weeks of age, renal damage was fully established. These data suggest an accelerated lesion through glucolipotoxic effects in the renal pathogenesis in POKO mice

  9. Self-accelerated development of salt karst during flash floods along the Dead Sea Coast, Israel

    NASA Astrophysics Data System (ADS)

    Avni, Yoav; Lensky, Nadav; Dente, Elad; Shviro, Maayan; Arav, Reuma; Gavrieli, Ittai; Yechieli, Yoseph; Abelson, Meir; Lutzky, Hallel; Filin, Sagi; Haviv, Itai; Baer, Gidon

    2016-01-01

    We document and analyze the rapid development of a real-time karst system within the subsurface salt layers of the Ze'elim Fan, Dead Sea, Israel by a multidisciplinary study that combines interferometric synthetic aperture radar and light detection and ranging measurements, sinkhole mapping, time-lapse camera monitoring, groundwater level measurements and chemical and isotopic analyses of surface runoff and groundwater. The >1 m/yr drop of Dead Sea water level and the subsequent change in the adjacent groundwater system since the 1960s resulted in flushing of the coastal aquifer by fresh groundwater, subsurface salt dissolution, gradual land subsidence and formation of sinkholes. Since 2010 this process accelerated dramatically as flash floods at the Ze'elim Fan were drained by newly formed sinkholes. During and immediately after these flood events the dissolution rates of the subsurface salt layer increased dramatically, the overlying ground surface subsided, a large number of sinkholes developed over short time periods (hours to days), and salt-saturated water resurged downstream. Groundwater flow velocities increased by more than 2 orders of magnitudes compared to previously measured velocities along the Dead Sea. The process is self-accelerating as salt dissolution enhances subsidence and sinkhole formation, which in turn increase the ponding areas of flood water and generate additional draining conduits to the subsurface. The rapid terrain response is predominantly due to the highly soluble salt. It is enhanced by the shallow depth of the salt layer, the low competence of the newly exposed unconsolidated overburden and the moderate topographic gradients of the Ze'elim Fan.

  10. Economic analysis of opportunities to accelerate Alzheimer’s disease research and development

    PubMed Central

    Scott, Troy J; O'Connor, Alan C; Link, Albert N; Beaulieu, Travis J

    2014-01-01

    The development of disease-modifying treatments for Alzheimer's disease (AD) faces a number of barriers. Among these are the lack of surrogate biomarkers, the exceptional size and duration of clinical trials, difficulties in identifying appropriate populations for clinical trials, and the limitations of monotherapies in addressing such a complex multifactorial disease. This study sets out to first estimate the consequent impact on the expected cost of developing disease-modifying treatments for AD and then to estimate the potential benefits of bringing together industry, academic, and government stakeholders to co-invest in, for example, developing better biomarkers and cognitive assessment tools, building out advanced registries and clinical trial-readiness cohorts, and establishing clinical trial platforms to investigate combinations of candidate drugs and biomarkers from the portfolios of multiple companies. Estimates based on interviews with experts on AD research and development suggest that the cost of one new drug is now $5.7 billion (95% confidence interval (CI) $3.7–9.5 billion) and could be reduced to $2.0 billion (95% CI $1.5–2.9 billion). The associated acceleration in the arrival of disease-modifying treatments could reduce the number of case years of dementia by 7.0 million (95% CI 4.4–9.4 million) in the United States from 2025 through 2040. PMID:24673372

  11. Microdosing, imaging biomarkers and SPECT: a multi-sided tripod to accelerate drug development.

    PubMed

    Pauwels, Ernest K J; Bergstrom, Kim; Mariani, Giuliano; Kairemo, Kalevi

    2009-01-01

    The advances of nuclear medicine imaging instrumentation and radiopharmaceutical sciences allow their involvement in the developmental processes of therapeutic drugs. New chemical entities, meant as potential drugs, need to comply with the proof-of-principle. Tomographic imaging methods as PET, SPECT and CT have been used for small animal and human studies at an early stage of drug development. Using a drug candidate in a radiolabeled form in obtaining quantitative imaging data provides opportunity for a complete morphological and functional overview of targeting properties and overall pharmacokinetics. This can be helpful in go/no-go decision making. Microdosing, using e.g.1% of the proposed dose of the radiolabeled potential drug plays an important part in this early development and notably reduces the risk of serious adverse effects in human volunteers or patients. This paper primarily focuses on the way in which microdosing and SPECT imaging may contribute to the development of drugs. Furthermore, this paper illustrates how these techniques may help to eliminate weak drug candidates at early stage, making time and funds available for potential lead compounds. Eventually this approach facilitates and accelerates new drug approval. The present paper highlights how these techniques make drug development easier in the field of oncology and neurology.

  12. An accelerated remedial strategy developed for J-Field, Aberdeen Proving Ground, Maryland

    SciTech Connect

    Yuen, C.R.; Martino, L.; Patton, T.; Wrobel, J.

    1995-06-01

    For an installation with many disposal sites and multiple contaminant sources, successful remediation at minimum cost can be complicated by insufficient geologic and hydrogeologic information, incomplete records of historical disposal activities, and uncertainty about the effectiveness of different investigative methods. To reduce these uncertainties and to increase the probability of successful remediation at minimum cost, a ``Phased and pilot`` accelerated remedial strategy has been developed for the J-Field area of Aberdeen Proving Ground, Maryland. The strategy includes four phases. First, the most contaminated site is selected as a pilot for detailed investigation. Second, the most contaminated areas within the pilot site are chosen as a pilot source area for interim action study, and a remedial action is developed to remove the primary contaminant sources. The subsequent sitewide investigation uses the effective tools developed in the first phase. Third, a cleanup operation is initiated in the pilot source area, while a sitewide feasibility study is developed by taking advantage of lessons learned in the interim action. Fourth, a sitewide cleanup operation proceeds.

  13. Economic analysis of opportunities to accelerate Alzheimer's disease research and development.

    PubMed

    Scott, Troy J; O'Connor, Alan C; Link, Albert N; Beaulieu, Travis J

    2014-04-01

    The development of disease-modifying treatments for Alzheimer's disease (AD) faces a number of barriers. Among these are the lack of surrogate biomarkers, the exceptional size and duration of clinical trials, difficulties in identifying appropriate populations for clinical trials, and the limitations of monotherapies in addressing such a complex multifactorial disease. This study sets out to first estimate the consequent impact on the expected cost of developing disease-modifying treatments for AD and then to estimate the potential benefits of bringing together industry, academic, and government stakeholders to co-invest in, for example, developing better biomarkers and cognitive assessment tools, building out advanced registries and clinical trial-readiness cohorts, and establishing clinical trial platforms to investigate combinations of candidate drugs and biomarkers from the portfolios of multiple companies. Estimates based on interviews with experts on AD research and development suggest that the cost of one new drug is now $5.7 billion (95% confidence interval (CI) $3.7-9.5 billion) and could be reduced to $2.0 billion (95% CI $1.5-2.9 billion). The associated acceleration in the arrival of disease-modifying treatments could reduce the number of case years of dementia by 7.0 million (95% CI 4.4-9.4 million) in the United States from 2025 through 2040.

  14. Development of High-Gradient Dielectric Laser-Driven Particle Accelerator Structures

    SciTech Connect

    Byer, Robert L.

    2013-11-07

    The thrust of Stanford's program is to conduct research on high-gradient dielectric accelerator structures driven with high repetition-rate, tabletop infrared lasers. The close collaboration between Stanford and SLAC (Stanford Linear Accelerator Center) is critical to the success of this project, because it provides a unique environment where prototype dielectric accelerator structures can be rapidly fabricated and tested with a relativistic electron beam.

  15. Acceleration modules in linear induction accelerators

    NASA Astrophysics Data System (ADS)

    Wang, Shao-Heng; Deng, Jian-Jun

    2014-05-01

    The Linear Induction Accelerator (LIA) is a unique type of accelerator that is capable of accelerating kilo-Ampere charged particle current to tens of MeV energy. The present development of LIA in MHz bursting mode and the successful application into a synchrotron have broadened LIA's usage scope. Although the transformer model is widely used to explain the acceleration mechanism of LIAs, it is not appropriate to consider the induction electric field as the field which accelerates charged particles for many modern LIAs. We have examined the transition of the magnetic cores' functions during the LIA acceleration modules' evolution, distinguished transformer type and transmission line type LIA acceleration modules, and re-considered several related issues based on transmission line type LIA acceleration module. This clarified understanding should help in the further development and design of LIA acceleration modules.

  16. Development of integrated superconducting quadrupole doublet modules for operation in the SIS100 accelerator

    NASA Astrophysics Data System (ADS)

    Meier, J.; Bleile, A.; Ceballos Velasco, J.; Fischer, E.; Hess, G.; Macavei, J.; Spiller, P.

    2015-12-01

    The FAIR project (Facility for Antiproton and Ion Research) evolves and builds an international accelerator- and experimental facility for basic research activities in various fields of modern physics. Within the course of this project, integrated quadrupole doublet modules are in development. The quadrupole doublet modules provide a pair of superconducting main quadrupoles (focusing and defocusing), corrector magnets, cryogenic collimators and beam position monitors as integrated sets of ion-optical elements. Furthermore LHe cooled beam pipes and vacuum cold-warm transitions are used as ultra-high vacuum components for beam transportation. Superconducting bus bars are used for 13 kA current supply of the main quadrupole magnets. All components are integrated as one common cold mass into one cryostat. High temperature super conductor local current leads will be applied for the low current supply of corrector magnets. The quadrupole doublet modules will be operated in the SIS100 heavy ion accelerator, the core component of the FAIR project. A first version of a corrector magnet has already been manufactured at the Joint Institute for Nuclear Research (JINR), Russia, and is now ready for testing. The ion-optical lattice structure of SIS100 requires multiple configurations of named components. Eleven different configurations, organized in four categories, provide the required quadrupole doublet module setups. The high integration level of multiple ion-optical, mechanical and cryogenic functions, based on requirements of operation safety, is leading towards a sophisticated mechanical structure and cooling solution, to satisfy the demanding requirements on position preservation during thermal cycling. The mechanical and cryogenic design solutions will be discussed.

  17. Working session 2: Tubing inspection

    SciTech Connect

    Guerra, J.; Tapping, R.L.

    1997-02-01

    This session was attended by delegates from 10 countries, and four papers were presented. A wide range of issues was tabled for discussion. Realizing that there was limited time available for more detailed discussion, three topics were chosen for the more detailed discussion: circumferential cracking, performance demonstration (to focus on POD and sizing), and limits of methods. Two other subsessions were organized: one dealt with some challenges related to the robustness of current inspection methods, especially with respect to leaving cracked tubes in service, and the other with developing a chart of current NDE technology with recommendations for future development. These three areas are summarized in turn, along with conclusions and/or recommendations. During the discussions there were four presentations. There were two (Canada, Japan) on eddy current probe developments, both of which addressed multiarray probes that would detect a range of flaws, one (Spain) on circumferential crack detection, and one (JRC, Petten) on the recent PISC III results.

  18. Optimising translational oncology in clinical practice: strategies to accelerate progress in drug development.

    PubMed

    Stahel, R; Bogaerts, J; Ciardiello, F; de Ruysscher, D; Dubsky, P; Ducreux, M; Finn, S; Laurent-Puig, P; Peters, S; Piccart, M; Smit, E; Sotiriou, C; Tejpar, S; Van Cutsem, E; Tabernero, J

    2015-02-01

    Despite intense efforts, the socioeconomic burden of cancer remains unacceptably high and treatment advances for many common cancers have been limited, suggesting a need for a new approach to drug development. One issue central to this lack of progress is the heterogeneity and genetic complexity of many tumours. This results in considerable variability in therapeutic response and requires knowledge of the molecular profile of the tumour to guide appropriate treatment selection for individual patients. While recent advances in the molecular characterisation of different cancer types have the potential to transform cancer treatment through precision medicine, such an approach presents a major economic challenge for drug development, since novel targeted agents may only be suitable for a small cohort of patients. Identifying the patients who would benefit from individual therapies and recruiting sufficient numbers of patients with particular cancer subtypes into clinical trials is challenging, and will require collaborative efforts from research groups and industry in order to accelerate progress. A number of molecular screening platforms have already been initiated across Europe, and it is hoped that these networks, along with future collaborations, will benefit not only patients but also society through cost reductions as a result of more efficient use of resources. This review discusses how current developments in translational oncology may be applied in clinical practice in the future, assesses current programmes for the molecular characterisation of cancer and describes possible collaborative approaches designed to maximise the benefits of translational science for patients with cancer.

  19. Accelerating the development of improved analgesic treatments: the ACTION public-private partnership.

    PubMed

    Dworkin, Robert H; Turk, Dennis C

    2011-07-01

    There has been considerable progress identifying pathophysiologic mechanisms of neuropathic pain, but analgesic medications with improved efficacy, safety, and tolerability still represent an unmet public health need. Numerous treatments examined in recent randomized clinical trials (RCTs) have failed to show efficacy for neuropathic pain, including treatments that had previously demonstrated efficacy. This suggests that at least some negative results reflect limited assay sensitivity of RCTs to distinguish efficacious treatments from placebo. Patient characteristics, clinical trial research designs and methods, outcome measures, approaches to data analysis, and statistical power may all play a role in accounting for difficulties in demonstrating the benefits of efficacious analgesic treatments vs placebo. The identification of specific clinical trial characteristics associated with assay sensitivity in existing data has the potential to provide an evidence-based approach to the design of analgesic clinical trials. The US Food and Drug Administration recently launched the Analgesic Clinical Trial Innovations, Opportunities, and Networks (ACTION) public-private partnership, which is designed to facilitate the discovery and development of analgesics with improved efficacy, safety, and tolerability for acute and chronic pain conditions. ACTION will establish a collaborative effort to prioritize research objectives, develop a standardized analgesic database platform, and conduct methodologically focused studies to increase the assay sensitivity and efficiency of analgesic clinical trials. The results of these activities have the potential to inform and accelerate the development of improved pain management interventions of all types, not just pharmacologic treatments.

  20. Development of a Laser-Powered Dielectric Structure-Based Accelerator as a Stand-Alone Particle Source

    NASA Astrophysics Data System (ADS)

    Yoder, R. B.; Travish, G.; Arab, E. R.; Fong, D.; Hoyer, Z.; Lacroix, U. H.; Vartanian, N.; Rosenzweig, J. B.

    2010-11-01

    An experimental program to develop and build a dielectric-based slab-symmetric structure (the micro-accelerator platform, or MAP) for generating and accelerating low-energy electrons is underway at UCLA and Manhattanville College. This optical acceleration structure is effectively a resonant cavity powered by a side-coupled laser, and has applications as a radiation source for medicine or industry. We present recent experimental and computational results on the accelerator, and progress toward its incorporation into a self-contained particle source. Such a particle source would incorporate a micron-scale electron emitter and a non-relativistic capture region to enable self-injection into the synchronous field within the accelerator. A prototype of the accelerator itself has been constructed from candidate dielectric materials using micromanufacturing techniques; the current status of the testing program is described. A novel electron emitter incorporating pyroelectric crystals with field-enhancing tips has been demonstrated to produce steady currents; the results are dependent on tip geometry, and appear suitable for injection into a microstructure. Extension of the MAP concept to non-relativistic velocities, as in the stand-alone source, requires a tapered structure that gives rise to numerous complications including beam defocusing and manufacturing challenges; approaches for addressing these complications are mentioned.

  1. Development of a dual-pulse RF driver for an S-band (= 2856 MHz) RF electron linear accelerator

    NASA Astrophysics Data System (ADS)

    Cha, Sungsu; Kim, Yujong; Lee, Byeong-No; Lee, Byung Cheol; Cha, Hyungki; Ha, Jang Ho; Park, Hyung Dal; Lee, Seung Hyun; Kim, Hui Su; Buaphad, Pikad

    2016-04-01

    The radiation equipment research division of Korea Atomic Energy Research Institute has developed a Container Inspection System (CIS) using a Radio Frequency (RF) electron linear accelerator for port security. The primary purpose of the CIS is to detect nuclear materials and explosives, as well country-specific prohibited substances, e.g., smuggled. The CIS consists of a 9/6 MeV dualenergy electron linear accelerator for distinguishing between organic and inorganic materials. The accelerator consists of an electron gun, an RF accelerating structure, an RF driver, a modulator, electromagnets, a cooling system, a X-ray generating target, X-ray collimator, a detector, and a container moving system. The RF driver is an important part of the configuration because it is the RF power source: it supplies the RF power to the accelerating structure. A unique aspect of the RF driver is that it generates dual RF power to generate dual energy (9/6 MeV). The advantage of this RF driver is that it can allow the pulse width to vary and can be used to obtain a wide range of energy output, and pulse repetition rates up to 300 Hz. For this reason, 140 W (5 MW - 9 MeV) and 37 W (3.4 MW - 6 MeV) power outputs are available independently. A high power test for 20 minutes demonstrate that stable dual output powers can be generated. Moreover, the dual power can be applied to the accelerator which has stable accelerator operation. In this paper, the design, fabrication and high power test of the RF driver for the RF electron linear accelerator (linac) are presented.

  2. Working session 1: Tubing degradation

    SciTech Connect

    Kharshafdjian, G.; Turluer, G.

    1997-02-01

    A general introductory overview of the purpose of the group and the general subject area of SG tubing degradation was given by the facilitator. The purpose of the session was described as to {open_quotes}develop conclusions and proposals on regulatory and technical needs required to deal with the issues of SG tubing degradation.{close_quotes} Types, locations and characteristics of tubing degradation in steam generators were briefly reviewed. The well-known synergistic effects of materials, environment, and stress and strain/strain rate, subsequently referred to by the acronym {open_quotes}MESS{close_quotes} by some of the group members, were noted. The element of time (i.e., evolution of these variables with time) was emphasized. It was also suggested that the group might want to consider the related topics of inspection capabilities, operational variables, degradation remedies, and validity of test data, and some background information in these areas was provided. The presentation given by Peter Millet during the Plenary Session was reviewed; Specifically, the chemical aspects and the degradation from the secondary side of the steam generator were noted. The main issues discussed during the October 1995 EPRI meeting on secondary side corrosion were reported, and a listing of the potential SG tube degradations was provided and discussed.

  3. Introduction to the Special Session on Thermal Remote Sensing Data for Earth Science Research: The Critical Need for Continued Data Collection and Development of Future Thermal Satellite Sensors

    NASA Technical Reports Server (NTRS)

    Quattrochi, Dale a.; Luvall, Jeffrey C.; Anderson, Martha; Hook, Simon

    2006-01-01

    There is a rich and long history of thermal infrared (TIR) remote sensing data for multidisciplinary Earth science research. The continuity of TIR data collection, however, is now in jeopardy given there are no planned future Earth observing TIR remote sensing satellite systems with moderately high spatial resolutions to replace those currently in orbit on NASA's Terra suite of sensors. This session will convene researchers who have actively worked in the field of TIR remote sensing to present results that elucidate the importance of thermal remote sensing to the wider Earth science research community. Additionally, this session will also exist as a forum for presenting concepts and ideas for new thermal sensing systems with high spatial resolutions for future Earth science satellite missions, as opposed to planned systems such as the Visible/Infrared Imager/Radiometer (VIIRS) suite of sensors on the National Polar-orbiting Operational Environmental Satellite System (NPOESS) that will collect TIR data at very coarse iairesolutions.

  4. Development of a subway operation incident delay model using accelerated failure time approaches.

    PubMed

    Weng, Jinxian; Zheng, Yang; Yan, Xuedong; Meng, Qiang

    2014-12-01

    This study aims to develop a subway operational incident delay model using the parametric accelerated time failure (AFT) approach. Six parametric AFT models including the log-logistic, lognormal and Weibull models, with fixed and random parameters are built based on the Hong Kong subway operation incident data from 2005 to 2012, respectively. In addition, the Weibull model with gamma heterogeneity is also considered to compare the model performance. The goodness-of-fit test results show that the log-logistic AFT model with random parameters is most suitable for estimating the subway incident delay. First, the results show that a longer subway operation incident delay is highly correlated with the following factors: power cable failure, signal cable failure, turnout communication disruption and crashes involving a casualty. Vehicle failure makes the least impact on the increment of subway operation incident delay. According to these results, several possible measures, such as the use of short-distance and wireless communication technology (e.g., Wifi and Zigbee) are suggested to shorten the delay caused by subway operation incidents. Finally, the temporal transferability test results show that the developed log-logistic AFT model with random parameters is stable over time.

  5. Accelerating the development of formal thinking in middle and high school students

    NASA Astrophysics Data System (ADS)

    Adey, Philip; Shayer, Michael

    In an attempt to accelerate the development of formal operations in average young adolescents, intervention lessons relating to all formal schemata were designed in the context of school science courses. Over a period of two years, up to 30 intervention lessons were given by science teachers to their classes in eight schools. Boys who started the program aged 12+ showed a pre-posttest effect size on Piagetian tests of 0.89 SD compared with control classes. In terms of British norms for the development of operational thinking this was a mean change from the 51st to the 74th percentile. Neither the middle school students nor the 12+ girls showed greater gain than the controls. Gains were shown by girls in one 11+ class and in the two 11+ laboratory classes. In the laboratory school students given intervention lessons by the researchers maintained their gains over controls in formal operations at a delayed posttest one year after cessation of the program. There was no effect on tests of science achievement during the intervention. It was argued that the interventions needed to be accompanied by in-service training designed to enable teachers to change their teaching style in line with their students' increased operational thinking capacity.

  6. Nutrition Session Summary

    NASA Technical Reports Server (NTRS)

    Lane, Helen; Stein, T. P.

    1999-01-01

    Nutrition deficiencies affect multiple systems including muscle, bone, cardiovascular, renal, and gastrointestinal. Humans require many nutrients, ranging from the macronutrients (water, protein, energy sources) to micronutrients (minerals, vitamins). The ability to withstand shortfalls in intake of individual nutrients ranges from one or two days (e.g., water) to weeks (energy, protein, potassium) and months (some vitamins, minerals). In addition to putting humans at risk for nutrition deficiencies, space flight may also change the absorption, hence the pharmacodynamics, of several important medications. Papers given in this session dealt with all of these nutritional and pharmacological factors related to space flight: (1) Protein metabolism and muscle formation. (2) Pharmacodynamics. (3) Calcium metabolism and bone formation/resorption. and (4) Fluid and electrolytes.

  7. Three featured plenary sessions

    NASA Astrophysics Data System (ADS)

    2012-07-01

    The conference included three plenary sessions. The plenary on Governance, Security, Economy, and the Ecosystem of the Changing Arctic featured Vera Alexander, president, Arctic Research Consortium of the U.S.; Alan Thornhill, chief environmental officer, U.S. Department of the Interior's Bureau of Ocean Energy Management; and Fran Ulmer, chair, U.S. Arctic Research Commission. A plenary on the U.N. Convention on the Law of the Sea featured Ambassador David Balton, deputy assistant secretary for oceans and fisheries, U.S. Department of State; and Rear Admiral Frederick Kenney Jr., judge advocate general and chief counsel, U.S. Coast Guard. The plenary on Science and the 21st Century featured Phil Keslin, chief technology officer, small lab within Google.

  8. Session: Discussion of Research Needs

    SciTech Connect

    anon.

    2004-09-01

    This final session at the Wind Energy and Birds/Bats workshop was lead by a facilitator who asked participants for their overall reaction to the research that had been presented during the workshop. Questions addressed by workshop participants included: how do you develop trust and confidence in the research, what are some of the specific gaps in our understanding of wind energy's impact on birds and bats; how do we prioritize and proceed with closing the data/research gaps; how do we connect the dots and bring various research and mapping efforts together; given gaps in the data, what are the critical questions we need to answer to make project decisions now; and, how do we track/influence the policies that will shape wind energy development. Conclusions reached regarding these questions are included in summary form.

  9. Development of a new concept automatic frequency controller for an ultrasmall C-band linear accelerator guide.

    PubMed

    Kamino, Yuichiro; Tsukuda, Kazuhiro; Kokubo, Masaki; Miura, Sadao; Hirai, Etsuro; Hiraoka, Masahiro; Ishikawa, Junzo

    2007-08-01

    We are developing a four-dimensional, image-guided radiotherapy system with a gimbaled x-ray head. The system has pursuing irradiation capability in addition to precise irradiation capability, owing to its agile x-ray head. The moving x-ray head requires a very small C-band accelerator guide. The heat intensity of the accelerator guide is much higher than that of conventional S-band medical linear accelerators. The resonance frequency varies over almost 1.0 MHz with a thermal time constant of about 30 s. An automatic frequency controller (AFC) is employed to compensate for this variation in resonance frequency. Furthermore, we noted that fast AFC response is important for step-and-shoot intensity modulation radiotherapy (IMRT), in which the beam is turned on and off frequently. Therefore, we invented a digital AFC, based on a new concept, to provide effective compensation for the thermal characteristics of the accelerator guide and to ensure stable and optimized x-ray treatment. An important aspect of the performance of the AFC is the capture-frequency range over which the AFC can seek, lock on to, and track the resonance frequency. The conventional, analog AFC used in S-band medical linear accelerators would have a capture-frequency range of about 0.9 MHz, if applied to our accelerator guide, and would be inappropriate. Conversely, our new AFC has a capture-frequency range of 24 MHz, which is well suited to our accelerator guide. The design concept behind this new AFC has been developed and verified. A full prototype system was constructed and tested on an existing accelerator guide at the rated x-ray output (500 cGy/min) of our radiotherapy system, with a pulse-repetition frequency of 300 Hz. The AFC acquired the resonance frequency of the accelerator guide within 0.15 s after beam-on, and provided stable tracking and adjustment of the frequency of the microwave source to the resonance frequency of the accelerator guide. With a planned improvement of the

  10. Development of an Accelerated Test Design for Predicting the Service Life of the Solar Array at Mead, Nebraska

    NASA Technical Reports Server (NTRS)

    Gaines, G. B.; Thomas, R. E.; Noel, G. T.; Shilliday, T. S.; Wood, V. E.; Carmichael, D. C.

    1979-01-01

    An accelerated life test is described which was developed to predict the life of the 25 kW photovoltaic array installed near Mead, Nebraska. A quantitative model for accelerating testing using multiple environmental stresses was used to develop the test design. The model accounts for the effects of thermal stress by a relation of the Arrhenius form. This relation was then corrected for the effects of nonthermal environmental stresses, such as relative humidity, atmospheric pollutants, and ultraviolet radiation. The correction factors for the nonthermal stresses included temperature-dependent exponents to account for the effects of interactions between thermal and nonthermal stresses on the rate of degradation of power output. The test conditions, measurements, and data analyses for the accelerated tests are presented. Constant-temperature, cyclic-temperature, and UV types of tests are specified, incorporating selected levels of relative humidity and chemical contamination and an imposed forward-bias current and static electric field.

  11. Development and applications of a multi-purpose digital controller with a System-on-Chip FPGA for accelerators

    NASA Astrophysics Data System (ADS)

    Kurimoto, Yoshinori; Nakamura, Keigo

    2016-12-01

    J-PARC Main Ring (MR) is a high intensity proton synchrotron which accelerates protons from 3 GeV to 30 GeV. It has operated at a beam intensity of 390 kW and an upgrade toward the megawatt rating is scheduled. For higher beam intensity, some of the accelerator components require more intelligent and complicated functions. To consolidate such functions among various components, we developed multi-purpose digital boards using a System-on-Chip Field-Programmable Gated Array (SoC FPGA). In this paper, we describe the details of our developed boards as well as their possible applications. As an application of the boards, we have successfully performed the measurement of the betatron amplitude function during beam acceleration in J-PARC MR. The experimental setup and results of the measurement are also described in detail.

  12. Acceleration Studies

    NASA Technical Reports Server (NTRS)

    Rogers, Melissa J. B.

    1993-01-01

    Work to support the NASA MSFC Acceleration Characterization and Analysis Project (ACAP) was performed. Four tasks (analysis development, analysis research, analysis documentation, and acceleration analysis) were addressed by parallel projects. Work concentrated on preparation for and implementation of near real-time SAMS data analysis during the USMP-1 mission. User support documents and case specific software documentation and tutorials were developed. Information and results were presented to microgravity users. ACAP computer facilities need to be fully implemented and networked, data resources must be cataloged and accessible, future microgravity missions must be coordinated, and continued Orbiter characterization is necessary.

  13. The effect of a cold beverage during an exercise session combining both strength and energy systems development training on core temperature and markers of performance

    PubMed Central

    2012-01-01

    Background Although studies have investigated the effects of hydration on performance measures, few studies have investigated how the temperature of the ingested liquid affects performance and core temperature during an exercise session. The hypothesis of the present study was that cold water would improve thermoregulation and performance as measured by bench repetitions to fatigue, broad jump for force and power and total time to exhaustion for cardiovascular fitness Methods Forty-five, physically fit, adult males (30.28 ± 5.4 yr, 1.77 ± 7.8 m, 83.46 ± 11.5 kg; 13.7 ± 4.8 %BF; 49.8 ± 6.3 ml/kg/min V02) completed two 60-minute exercise sessions. Subjects consumed either COLD (4°C) or room temperature (RT) water (22°C) in randomized order. Core temperature was measured every 15 minutes throughout each trial using a digestible thermometer. Three performance tests were performed upon completion of the exercise session: bench press to fatigue, standing broad jump, and bicycle time to exhaustion Results Although both groups significantly increased their core temperature (p<0.001) over the course of the exercise session and presented a significant decline in hydration status (p<0.001), participants in the COLD water trial had a significantly (p=0.024) smaller rise in core temperature (0.83°) over the duration of the trial in comparison to RT (1.13°). The participants in the COLD water trial were able to delay their increase in core body temperature for at least 30 minutes, whereas participants in the RT trial increased body temperature from baseline after 15 minutes. There was no significant difference between the COLD or the RT trials in broad jump and TTE performance tests. Bench press showed a small, albeit significant (p=0.046), decrease in performance when drinking COLD Conclusion Drinking cold water can significantly mediate and delay the increase in core body temperature during an exercise session in a moderate climate with euhydrated subjects. The

  14. The MIT HEDP Accelerator Facility for education and advanced diagnostics development for OMEGA, Z and the NIF

    NASA Astrophysics Data System (ADS)

    Petrasso, R.; Gatu Johnson, M.; Armstrong, E.; Han, H. W.; Kabadi, N.; Lahmann, B.; Orozco, D.; Rojas Herrera, J.; Sio, H.; Sutcliffe, G.; Frenje, J.; Li, C. K.; Séguin, F. H.; Leeper, R.; Ruiz, C. L.; Sangster, T. C.

    2015-11-01

    The MIT HEDP Accelerator Facility utilizes a 135-keV linear electrostatic ion accelerator, a D-T neutron source and two x-ray sources for development and characterization of nuclear diagnostics for OMEGA, Z, and the NIF. The ion accelerator generates D-D and D-3He fusion products through acceleration of D ions onto a 3He-doped Erbium-Deuteride target. Fusion reaction rates around 106 s-1 are routinely achieved, and fluence and energy of the fusion products have been accurately characterized. The D-T neutron source generates up to 6 × 108 neutrons/s. The two x-ray generators produce spectra with peak energies of 35 keV and 225 keV and maximum dose rates of 0.5 Gy/min and 12 Gy/min, respectively. Diagnostics developed and calibrated at this facility include CR-39 based charged-particle spectrometers, neutron detectors, and the particle Time-Of-Flight (pTOF) and Magnetic PTOF CVD-diamond-based bang time detectors. The accelerator is also a vital tool in the education of graduate and undergraduate students at MIT. This work was supported in part by SNL, DOE, LLE and LLNL.

  15. DEVELOPMENT OF WATER JET PLASMA MIRROR FOR STAGING OF LASER PLASMA ACCELERATORS

    SciTech Connect

    Panasenko, Dmitriy; Gonsalves, Anthony J.; Leemans, Wim; Nakamura, Kei; Shu, Anthony; Toth, Csaba

    2009-05-04

    Staging Laser Plasma Accelerators (LPAs) is necessary in order to reach beam energies of 100 GeV and above. This requires incoupling of additional laser beams into accelerating stages. In order to maintain the high average accelerating gradient of a staged LPA, it is imperative to minimize the distance that is needed for laser incoupling. A plasma mirror is proposed as the final coupling optic reducing the coupling distance from tens of meters, using a conventional optic, to as small as a few cm. Both a planar water jet and a nitrocellulose foil are used as reflecting surfacesand characterized. A maximum reflectivity of 70percent was obtained using both surfaces.

  16. Losartan increases bone mass and accelerates chondrocyte hypertrophy in developing skeleton

    PubMed Central

    Rianon, Nahid; Rajagopal, Abbhirami; Munivez, Elda; Bertin, Terry; Dawson, Brian; Chen, Yuqing; Jiang, Ming-Ming; Lee, Brendan; Yang, Tao; Bae, Yangjin

    2015-01-01

    Angiotensin receptor blockers (ARBs) are a group of anti-hypertensive drugs that are widely used to treat pediatric hypertension. Recent application of ARBs to treat diseases such as Marfan syndrome or Alport syndrome has shown positive outcomes in animal and human studies, suggesting a broader therapeutic potential for this class of drugs. Multiple studies have reported a benefit of ARBs on adult bone homeostasis; however, its effect on the growing skeleton in children is unknown. We investigated the effect of Losartan, an ARB, in regulating bone mass and cartilage during development in mice. Wild type mice were treated with Losartan from birth until 6 weeks of age, after which bones were collected for microCT and histomorphometric analyses. Losartan increased trabecular bone volume vs. tissue volume (a 98% increase) and cortical thickness (a 9% increase) in 6-weeks old wild type mice. The bone changes were attributed to decreased osteoclastogenesis as demonstrated by reduced osteoclast number per bone surface in vivo and suppressed osteoclast differentiation in vitro. At the molecular level, Angiotensin II-induced ERK1/2 phosphorylation in RAW cells was attenuated by Losartan. Similarly, RANKL-induced ERK1/2 phosphorylation was suppressed by Losartan, suggesting a convergence of RANKL and angiotensin signaling at the level of ERK1/2 regulation. To assess the effect of Losartan on cartilage development, we examined the cartilage phenotype of wild type mice treated with Losartan in utero from conception to 1 day of age. Growth plates of these mice showed an elongated hypertrophic chondrocyte zone and increased Col10a1 expression level, with minimal changes in chondrocyte proliferation. Altogether, inhibition of the angiotensin pathway by Losartan increases bone mass and accelerates chondrocyte hypertrophy in growth plate during skeletal development. PMID:25779879

  17. Losartan increases bone mass and accelerates chondrocyte hypertrophy in developing skeleton.

    PubMed

    Chen, Shan; Grover, Monica; Sibai, Tarek; Black, Jennifer; Rianon, Nahid; Rajagopal, Abbhirami; Munivez, Elda; Bertin, Terry; Dawson, Brian; Chen, Yuqing; Jiang, Ming-Ming; Lee, Brendan; Yang, Tao; Bae, Yangjin

    2015-05-01

    Angiotensin receptor blockers (ARBs) are a group of anti-hypertensive drugs that are widely used to treat pediatric hypertension. Recent application of ARBs to treat diseases such as Marfan syndrome or Alport syndrome has shown positive outcomes in animal and human studies, suggesting a broader therapeutic potential for this class of drugs. Multiple studies have reported a benefit of ARBs on adult bone homeostasis; however, its effect on the growing skeleton in children is unknown. We investigated the effect of Losartan, an ARB, in regulating bone mass and cartilage during development in mice. Wild type mice were treated with Losartan from birth until 6 weeks of age, after which bones were collected for microCT and histomorphometric analyses. Losartan increased trabecular bone volume vs. tissue volume (a 98% increase) and cortical thickness (a 9% increase) in 6-weeks old wild type mice. The bone changes were attributed to decreased osteoclastogenesis as demonstrated by reduced osteoclast number per bone surface in vivo and suppressed osteoclast differentiation in vitro. At the molecular level, Angiotensin II-induced ERK1/2 phosphorylation in RAW cells was attenuated by Losartan. Similarly, RANKL-induced ERK1/2 phosphorylation was suppressed by Losartan, suggesting a convergence of RANKL and angiotensin signaling at the level of ERK1/2 regulation. To assess the effect of Losartan on cartilage development, we examined the cartilage phenotype of wild type mice treated with Losartan in utero from conception to 1 day of age. Growth plates of these mice showed an elongated hypertrophic chondrocyte zone and increased Col10a1 expression level, with minimal changes in chondrocyte proliferation. Altogether, inhibition of the angiotensin pathway by Losartan increases bone mass and accelerates chondrocyte hypertrophy in growth plate during skeletal development.

  18. Development of TiN Coating System for Long Beam Ducts of Accelerators

    NASA Astrophysics Data System (ADS)

    Shibata, Kyo; Hisamatsu, Hiromi; Kanazawa, Ken-Ichi; Suetsugu, Yusuke; Shirai, Mitsuru

    A Titanium Nitride (TiN) coating system for long beam ducts of accelerators was developed to reduce the secondary electron yield (SEY) from the inner surface and to mitigate the electron cloud effect. Coating was carried out by DC magnetron sputtering of pure titanium in argon (2.0 Pa) and nitrogen (0.5 Pa) atmospheres. A copper beam duct with a maximum length of 3.6 m was set vertically, and a titanium rod as a cathode was suspended from the top along the central axis of the duct. A movable solenoid coil with a length of 0.8 m externally supplied a magnetic field of 16 mT to accommodate the long duct. By moving the solenoid coil at specified time intervals, the TiN film was uniformly coated on the inner surface. The thickness of the coating was 200 nm, and the temperature of the ducts during the coating was 130°C. Several coated ducts were installed into the KEKB positron ring during the summer shutdown in 2007. In the subsequent beam operation, the reduction of electrons in the coated duct was confirmed.

  19. Anticancer properties of nimbolide and pharmacokinetic considerations to accelerate its development

    PubMed Central

    Wang, Lingzhi; Phan, Do Dang Khoa; Zhang, Jingwen; Ong, Pei-Shi; Thuya, Win Lwin; Soo, Ross; Wong, Andrea Li-Ann; Yong, Wei Peng; Lee, Soo Chin; Ho, Paul Chi-Lui; Sethi, Gautam; Goh, Boon Cher

    2016-01-01

    Nimbolide is one of the main components in the leaf extract of Azadirachta indica (A. indica). Accumulating evidence from various in vitro and in vivo studies indicates that nimbolide possesses potent anticancer activity against several types of cancer and also shows potential chemopreventive activity in animal models. The main mechanisms of action of nimbolide include anti-proliferation, induction of apoptosis, inhibition of metastasis and angiogenesis, and modulation of carcinogen-metabolizing enzymes. Although multiple pharmacodynamic (PD) studies have been carried out, nimbolide is still at the infant stage in the drug development pipeline due to the lack of systematic pharmacokinetic (PK) studies and long-term toxicological studies. Preclinical PK and toxicological studies are vital in determining the dosage range to support the safety of nimbolide for first-in-human clinical trials. In this review, we will provide a comprehensive summary for the current status of nimbolide as an anticancer and chemopreventive lead compound, and highlight the importance of systematic preclinical PK and toxicological studies in accelerating the process of application of nimbolide as a therapeutic agent against various malignancies. PMID:27027349

  20. Development of a 15 T Nb3Sn accelerator dipole demonstrator at Fermilab

    DOE PAGES

    Novitski, I.; Andreev, N.; Barzi, E.; ...

    2016-06-01

    Here, a 100 TeV scale Hadron Collider (HC) with a nominal operation field of at least 15 T is being considered for the post-LHC era, which requires using the Nb3Sn technology. Practical demonstration of this field level in an accelerator-quality magnet and substantial reduction of the magnet costs are the key conditions for realization of such a machine. FNAL has started the development of a 15 T Nb3Sn dipole demonstrator for a 100 TeV scale HC. The magnet design is based on 4-layer shell type coils, graded between the inner and outer layers to maximize the performance and reduce themore » cost. The experience gained during the Nb3Sn magnet R&D is applied to different aspects of the magnet design. This paper describes the magnetic and structural designs and parameters of the 15 T Nb3Sn dipole and the steps towards the demonstration model fabrication.« less

  1. New developments of 11C post-accelerated beams for hadron therapy and imaging

    NASA Astrophysics Data System (ADS)

    Augusto, R. S.; Mendonca, T. M.; Wenander, F.; Penescu, L.; Orecchia, R.; Parodi, K.; Ferrari, A.; Stora, T.

    2016-06-01

    Hadron therapy was first proposed in 1946 and is by now widespread throughout the world, as witnessed with the design and construction of the CNAO, HIT, PROSCAN and MedAustron treatment centres, among others. The clinical interest in hadron therapy lies in the fact that it delivers precision treatment of tumours, exploiting the characteristic shape (the Bragg peak) of the energy deposition in the tissues for charged hadrons. In particular, carbon ion therapy is found to be biologically more effective, with respect to protons, on certain types of tumours. Following an approach tested at NIRS in Japan [1], carbon ion therapy treatments based on 12C could be combined or fully replaced with 11C PET radioactive ions post-accelerated to the same energy. This approach allows providing a beam for treatment and, at the same time, to collect information on the 3D distributions of the implanted ions by PET imaging. The production of 11C ion beams can be performed using two methods. A first one is based on the production using compact PET cyclotrons with 10-20 MeV protons via 14N(p,α)11C reactions following an approach developed at the Lawrence Berkeley National Laboratory [2]. A second route exploits spallation reactions 19F(p,X)11C and 23Na(p,X)11C on a molten fluoride salt target using the ISOL (isotope separation on-line) technique [3]. This approach can be seriously envisaged at CERN-ISOLDE following recent progresses made on 11C+ production [4] and proven post-acceleration of pure 10C3/6+ beams in the REX-ISOLDE linac [5]. Part of the required components is operational in radioactive ion beam facilities or commercial medical PET cyclotrons. The driver could be a 70 MeV, 1.2 mA proton commercial cyclotron, which would lead to 8.1 × 10711C6+ per spill. This intensity is appropriate using 11C ions alone for both imaging and treatment. Here we report on the ongoing feasibility studies of such approach, using the Monte Carlo particle transport code FLUKA [6,7] to simulate

  2. Developments in accelerators and instrumentation relevant to imaging with charged particles and positron emitters

    SciTech Connect

    Alonso, J.R.

    1980-11-01

    In past years particle accelerators have become increasingly important tools for the advancement of medical science. From the pace of advancing technology and current directions in medical research, it is clear that this relationship between accelerators and medicine will only grow stronger in future years. In view of this importance, this relationship is investigated in some detail, with an eye not so much towards the medical uses of the beams produced, but more towards the technology associated with these accelerators and the criteria which make for successful incorporation of these machines into the clinical environment. In order to lay the necessary groundwork, the different kinds of accelerators found in medical use today are reviewed briefly discussing salient points of each.

  3. Report of the Subpanel on Accelerator Research and Development of the High Energy Physics Advisory Panel

    SciTech Connect

    Not Available

    1980-06-01

    Accelerator R and D in the US High Energy Physics (HEP) program is reviewed. As a result of this study, some shift in priority, particularly as regards long-range accelerator R and D, is suggested to best serve the future needs of the US HEP program. Some specific new directions for the US R and D effort are set forth. 18 figures, 5 tables. (RWR)

  4. Development of a second generation stereotactic apparatus for linear accelerator radiosurgery.

    PubMed

    Colombo, F; Casentini, L; Pozza, F; Chierego, G; Marchetti, C

    1991-01-01

    Linear accelerator radiosurgery technique is based on a multiple intersecting arc irradiations procedure. The coincidence of the axis of two rotation movements (of gantry and treatment couch) into the isocenter is critical for focusing irradiation. In October 1989, our linear accelerator was changed and the stereotactic apparatus had to be adapted to the new machine. After multiple mechanical tests of the new machine, the stereotactic head frame was fixed to the roller bearing allowing rotation of the couch. The new apparatus is described.

  5. Accelerator Development for the NRL (Naval Research Laboratory) Free Electron Laser Program

    DTIC Science & Technology

    1988-06-01

    34triple point" junction of the vacuum , ceramic insulator , and metal electrode. This leads to the flashover of the insulator , causing an arc which acts as...tungsten wire (25.4 um) into the transport vacuum system. The diode is housed in an Astron ceramic insulator stack. The voltage profile across the diode...accelerator vacuum wall. It is across these insulating breaks that the accelerating voltage is applied to the electron beam and any breakdown in these gaps

  6. Development and Use of Mark Sense Record Cards for Recording Medical Data on Pilots Subjected to Acceleration Stress

    NASA Technical Reports Server (NTRS)

    Smedal, Harald A.; Havill, C. Dewey

    1962-01-01

    A TIME-HONORED system of recording medical histories and the data obtained on physical and laboratory examination has been that of writing the information on record sheets that go into a folder for each patient. In order to have information which would be more readily retrieved, 'a program was initiated in 1952 by the U. S. Naval School of Aviation Medicine in connection with their "Care of the Flyer" study to place this information on machine record cards. In 1958, a machine record card method was developed for recording medical data in connection with the astronaut selection program. Machine record cards were also developed by the Aero Medical Laboratory, Wright-Patterson AFB, Ohio, and the Aviation Medical Acceleration Laboratory, Naval Air Development Center, Johnsville, Pennsylvania, for use in connection with a variety of tests including acceleration stress.1 Therefore, a variety of systems resulted in which data of a medical nature could easily be recalled. During the NASA, Ames Research Center centrifuge studies/'S the pilot subjects were interviewed after each centrifuge run, or series of runs, and subjective information was recorded in a log book by the usual history taking methods referred to above. After the methods Were reviewed, it' was recognized that a card system would be very useful in recording data from our pilots after they had been exposed to acceleration stress. Since the acceleration stress cards already developed did not meet our requirements, it was decided a different card was needed.

  7. 96th LHCC meeting Agenda OPEN Session and CLOSED Session

    ScienceCinema

    None

    2016-07-12

    OPEN Session on Wednesday, 19 November 2008 at 9h00-11h00 in Main Auditorium, Live webcast. Followed by CLOSED Session , 6th floor Conference room and continued on Thursday, 20 November 2008 9h00-13h00

  8. Development of design technique for vacuum insulation in large size multi-aperture multi-grid accelerator for nuclear fusion

    SciTech Connect

    Kojima, A. Hanada, M.; Tobari, H.; Nishikiori, R.; Hiratsuka, J.; Kashiwagi, M.; Umeda, N.; Yoshida, M.; Ichikawa, M.; Watanabe, K.; Yamano, Y.; Grisham, L. R.

    2016-02-15

    Design techniques for the vacuum insulation have been developed in order to realize a reliable voltage holding capability of multi-aperture multi-grid (MAMuG) accelerators for fusion application. In this method, the nested multi-stage configuration of the MAMuG accelerator can be uniquely designed to satisfy the target voltage within given boundary conditions. The evaluation of the voltage holding capabilities of each acceleration stages was based on the previous experimental results about the area effect and the multi-aperture effect. Since the multi-grid effect was found to be the extension of the area effect by the total facing area this time, the total voltage holding capability of the multi-stage can be estimated from that per single stage by assuming the stage with the highest electric field, the total facing area, and the total apertures. By applying these consideration, the analysis on the 3-stage MAMuG accelerator for JT-60SA agreed well with the past gap-scan experiments with an accuracy of less than 10% variation, which demonstrated the high reliability to design MAMuG accelerators and also multi-stage high voltage bushings.

  9. Development of design technique for vacuum insulation in large size multi-aperture multi-grid accelerator for nuclear fusion.

    PubMed

    Kojima, A; Hanada, M; Tobari, H; Nishikiori, R; Hiratsuka, J; Kashiwagi, M; Umeda, N; Yoshida, M; Ichikawa, M; Watanabe, K; Yamano, Y; Grisham, L R

    2016-02-01

    Design techniques for the vacuum insulation have been developed in order to realize a reliable voltage holding capability of multi-aperture multi-grid (MAMuG) accelerators for fusion application. In this method, the nested multi-stage configuration of the MAMuG accelerator can be uniquely designed to satisfy the target voltage within given boundary conditions. The evaluation of the voltage holding capabilities of each acceleration stages was based on the previous experimental results about the area effect and the multi-aperture effect. Since the multi-grid effect was found to be the extension of the area effect by the total facing area this time, the total voltage holding capability of the multi-stage can be estimated from that per single stage by assuming the stage with the highest electric field, the total facing area, and the total apertures. By applying these consideration, the analysis on the 3-stage MAMuG accelerator for JT-60SA agreed well with the past gap-scan experiments with an accuracy of less than 10% variation, which demonstrated the high reliability to design MAMuG accelerators and also multi-stage high voltage bushings.

  10. Ghrelin accelerates synapse formation and activity development in cultured cortical networks

    PubMed Central

    2014-01-01

    Background While ghrelin was initially related to appetite stimulation and growth hormone secretion, it also has a neuroprotective effect in neurodegenerative diseases and regulates cognitive function. The cellular basis of those processes is related to synaptic efficacy and plasticity. Previous studies have shown that ghrelin not only stimulates synapse formation in cultured cortical neurons and hippocampal slices, but also alters some of the electrophysiological properties of neurons in the hypothalamus, amygdala and other subcortical areas. However, direct evidence for ghrelin’s ability to modulate the activity in cortical neurons is not available yet. In this study, we investigated the effect of acylated ghrelin on the development of the activity level and activity patterns in cortical neurons, in relation to its effect on synaptogenesis. Additionally, we quantitatively evaluated the expression of the receptor for acylated ghrelin – growth hormone secretagogue receptor-1a (GHSR-1a) during development. Results We performed electrophysiology and immunohistochemistry on dissociated cortical cultures from neonates, treated chronically with acylated ghrelin. On average 76 ± 4.6% of the cortical neurons expressed GHSR-1a. Synapse density was found to be much higher in ghrelin treated cultures than in controls across all age groups (1, 2 or 3 weeks). In all cultures (control and ghrelin treated), network activity gradually increased until it reached a maximum after approximately 3 weeks, followed by a slight decrease towards a plateau. During early developmental stages (1–2 weeks), the activity was much higher in ghrelin treated cultures and consequently, they reached the plateau value almost a week earlier than controls. Conclusions Acylated ghrelin leads to earlier network formation and activation in cultured cortical neuronal networks, the latter being a possibly consequence of accelerated synaptogenesis. PMID:24742241

  11. a Development of Accelerated Life Test Method for Blower Motor for Automobile Using Inverse Power Law Model

    NASA Astrophysics Data System (ADS)

    Shin, Wae-Gyeong; Lee, Soo-Hong

    Reliability of automotive parts has been one of the most interesting fields in the automotive industry. Especially small DC motor was issued because of the increasing adoption for passengers' safety and convenience. This study was performed to develop the accelerated life test method using Inverse power law model for small DC motors. The failure mode of small DC motor includes brush wear-out. Inverse power law model is applied effectively the electronic components to reduce the testing time and to achieve the accelerating test conditions. Accelerated life testing method was induced to bring on the brush wear-out as increasing voltage of motor. Life distribution of the small DC motor was supposed to follow Weibull distribution and life test time was calculated under the conditions of B10 life and 90% confidence level.

  12. Land subsidence session

    NASA Astrophysics Data System (ADS)

    Holzer, Thomas L.

    A session on land subsidence caused by withdrawal of groundwater was held December 10, 1985, in San Francisco, Calif., at the AGU Fall Meeting. The symposium was organized by William E. Strange (National Geodetic Survey, Rockville, Md.) and Thomas L. Holzer (U.S. Geological Survey (USGS), Menlo Park, Calif.) and was cosponsored by the AGU Geodesy and Hydrology sections. Nine papers were presented on topics that ranged from evaluations of the suitability of the new satellite-based Global Positioning System (GPS) to theoretical analyses of land subsidence.T. N. Narasimhan (Lawrence Berkeley Laboratories, Berkeley, Calif.) introduced the general subject of subsidence with a review of relevant physical processes. Compaction, although conceptually simple, involves several complexities, including plastic deformation and translation of deep-seated deformation through the overburden. Sashi Mathur (Tarleton State University, Stephenville, Tex.), in a paper coauthored with M. Yavuz Corapcioglu (City College of New York, New York), analyzed deformation in the unsaturated zone above a falling water table. Their theoretical formulation was able to reproduce results from laboratory studies of sand columns.

  13. Posters. [Poster Session at AHRD Conference, 2001].

    ERIC Educational Resources Information Center

    2001

    The first of the papers in this poster session, "Developing the Employment Brand: Targeting MBA Campus Hires" (Diane M. Bergeron), posits that employment branding benefits both individuals and organizations. It functions as a campus recruiting tool in a competitive labor market and communicates the organization's values and work…

  14. OJJDP Family Listening Sessions. Executive Summary

    ERIC Educational Resources Information Center

    Office of Juvenile Justice and Delinquency Prevention, 2013

    2013-01-01

    From March through July 2011, the Office of Juvenile Justice and Delinquency Prevention (OJJDP), in collaboration with the Campaign for Youth Justice and the Education Development Center, convened four listening sessions with families and youth who had direct experiences with the juvenile justice system at the local and state levels. The…

  15. Germline mutation of Bap1 accelerates development of asbestos-induced malignant mesothelioma.

    PubMed

    Xu, Jinfei; Kadariya, Yuwaraj; Cheung, Mitchell; Pei, Jianming; Talarchek, Jacqueline; Sementino, Eleonora; Tan, Yinfei; Menges, Craig W; Cai, Kathy Q; Litwin, Samuel; Peng, Hongzhuang; Karar, Jayashree; Rauscher, Frank J; Testa, Joseph R

    2014-08-15

    Malignant mesotheliomas are highly aggressive tumors usually caused by exposure to asbestos. Germline-inactivating mutations of BAP1 predispose to mesothelioma and certain other cancers. However, why mesothelioma is the predominate malignancy in some BAP1 families and not others, and whether exposure to asbestos is required for development of mesothelioma in BAP1 mutation carriers are not known. To address these questions experimentally, we generated a Bap1(+/-) knockout mouse model to assess its susceptibility to mesothelioma upon chronic exposure to asbestos. Bap1(+/-) mice exhibited a significantly higher incidence of asbestos-induced mesothelioma than wild-type (WT) littermates (73% vs. 32%, respectively). Furthermore, mesotheliomas arose at an accelerated rate in Bap1(+/-) mice than in WT animals (median survival, 43 weeks vs. 55 weeks after initial exposure, respectively) and showed increased invasiveness and proliferation. No spontaneous mesotheliomas were seen in unexposed Bap1(+/-) mice followed for up to 87 weeks of age. Mesothelioma cells from Bap1(+/-) mice showed biallelic inactivation of Bap1, consistent with its proposed role as a recessive cancer susceptibility gene. Unlike in WT mice, mesotheliomas from Bap1(+/-) mice did not require homozygous loss of Cdkn2a. However, normal mesothelial cells and mesothelioma cells from Bap1(+/-) mice showed downregulation of Rb through a p16(Ink4a)-independent mechanism, suggesting that predisposition of Bap1(+/-) mice to mesothelioma may be facilitated, in part, by cooperation between Bap1 and Rb. Drawing parallels to human disease, these unbiased genetic findings indicate that BAP1 mutation carriers are predisposed to the tumorigenic effects of asbestos and suggest that high penetrance of mesothelioma requires such environmental exposure.

  16. Linear Accelerators

    NASA Astrophysics Data System (ADS)

    Sidorin, Anatoly

    2010-01-01

    In linear accelerators the particles are accelerated by either electrostatic fields or oscillating Radio Frequency (RF) fields. Accordingly the linear accelerators are divided in three large groups: electrostatic, induction and RF accelerators. Overview of the different types of accelerators is given. Stability of longitudinal and transverse motion in the RF linear accelerators is briefly discussed. The methods of beam focusing in linacs are described.

  17. How can accelerated development of bioenergy contribute to the future UK energy mix? Insights from a MARKAL modelling exercise

    PubMed Central

    Clarke, Donna; Jablonski, Sophie; Moran, Brighid; Anandarajah, Gabrial; Taylor, Gail

    2009-01-01

    Background This work explores the potential contribution of bioenergy technologies to 60% and 80% carbon reductions in the UK energy system by 2050, by outlining the potential for accelerated technological development of bioenergy chains. The investigation was based on insights from MARKAL modelling, detailed literature reviews and expert consultations. Due to the number and complexity of bioenergy pathways and technologies in the model, three chains and two underpinning technologies were selected for detailed investigation: (1) lignocellulosic hydrolysis for the production of bioethanol, (2) gasification technologies for heat and power, (3) fast pyrolysis of biomass for bio-oil production, (4) biotechnological advances for second generation bioenergy crops, and (5) the development of agro-machinery for growing and harvesting bioenergy crops. Detailed literature searches and expert consultations (looking inter alia at research and development needs and economic projections) led to the development of an 'accelerated' dataset of modelling parameters for each of the selected bioenergy pathways, which were included in five different scenario runs with UK-MARKAL (MED). The results of the 'accelerated runs' were compared with a low-carbon (LC-Core) scenario, which assesses the cheapest way to decarbonise the energy sector. Results Bioenergy was deployed in larger quantities in the bioenergy accelerated technological development scenario compared with the LC-Core scenario. In the electricity sector, solid biomass was highly utilised for energy crop gasification, displacing some deployment of wind power, and nuclear and marine to a lesser extent. Solid biomass was also deployed for heat in the residential sector from 2040 in much higher quantities in the bioenergy accelerated technological development scenario compared with LC-Core. Although lignocellulosic ethanol increased, overall ethanol decreased in the transport sector in the bioenergy accelerated technological

  18. High intensity hadron accelerators

    SciTech Connect

    Teng, L.C.

    1989-05-01

    This rapporteur report consists mainly of two parts. Part I is an abridged review of the status of all High Intensity Hadron Accelerator projects in the world in semi-tabulated form for quick reference and comparison. Part II is a brief discussion of the salient features of the different technologies involved. The discussion is based mainly on my personal experiences and opinions, tempered, I hope, by the discussions I participated in in the various parallel sessions of the workshop. In addition, appended at the end is my evaluation and expression of the merits of high intensity hadron accelerators as research facilities for nuclear and particle physics.

  19. Research and Development of Wires and Cables for High-Field Accelerator Magnets

    SciTech Connect

    Barzi, Emanuela; Zlobin, Alexander V.

    2016-04-01

    The latest strategic plans for High Energy Physics endorse steadfast superconducting magnet technology R&D for future Energy Frontier Facilities. This includes 10 to 16 T Nb3Sn accelerator magnets for the luminosity upgrades of the Large Hadron Collider and eventually for a future 100 TeV scale proton-proton (pp) collider. This paper describes the multi-decade R&D investment in the Nb3Sn superconductor technology, which was crucial to produce the first reproducible 10 to 12 T accelerator-quality dipoles and quadrupoles, as well as their scale-up. We also indicate prospective research areas in superconducting Nb3Sn wires and cables to achieve the next goals for superconducting accelerator magnets. Emphasis is on increasing performance and decreasing costs while pushing the Nb3Sn technology to its limits for future pp colliders.

  20. Development of an RF Conditioning System for Charged-Particle Accelerators

    SciTech Connect

    Kang, Yoon W; Howlader, Mostofa; Shajedul Hasan, Dr. S. M.

    2008-01-01

    Charged-particle accelerators use various vacuum windows on their accelerating radio-frequency (RF) cavities to throughput very high RF power. Before being placed on the cavities, the windows should be cleaned, baked, and fully RF conditioned to prevent a poor vacuum from outgassing, as well as other forms of contamination. An example is the coaxial fundamental power coupler (FPC) with an annular alumina ceramic window for each of the 81 superconducting RF cavities in the Spallation Neutron Source (SNS) linear accelerator. The FPCs needed to be tested up to 650-kW peak in a traveling wave and 2.6 MW with standing wave peaks in 1.3 and 60 pulses/s at 805 MHz. In this paper, an Experimental-Physics-and-Industrial-Control-System-based RF conditioning system for the SNS RF test facility is presented. This paper summarizes the hardware and software design strategies, provides the results obtained, and describes the future research scope.

  1. Development of a 10 MW, 91 GHz Gyroklystron for W-Band Linear Accelerators

    NASA Astrophysics Data System (ADS)

    Nielson, Jeff; Ives, Lawrence; Lawson, Wes; Arjona, Melany

    1999-11-01

    An international effort is underway to design advanced linear electron-positron colliders with mass energies beyond 1 TeV. High power RF sources are required to drive accelerators operating at frequencies as high as W-Band. Calabazas Creek Research, Inc. is funded by the U.S. Department of Energy to design a 10 MW, second harmonic, gyroklystron at 91 GHz. The program is coordinated with W-Band accelerator research at the Stanford Linear Accelerator Center. The goal is to achieve an electronic efficiency of 45presentation will describe the proposed electron gun, three cavity RF circuit, magnetic circuit, and input and output couplers. Current simulation results will be presented and design tradeoffs will be discussed.

  2. CO2 enrichment accelerates successional development of an understory plant community

    SciTech Connect

    Souza, Lara; Belote, R. Travis Travis; Kardol, Paul; Weltzin, Jake; Norby, Richard J

    2010-01-01

    61% in aCO{sub 2} and only 33% in eCO{sub 2} treatments. Our results suggest that rising atmospheric [CO{sub 2}] could accelerate successional development and have longer term impact on forest dynamics.

  3. Angiotensin II accelerates mammary gland development independently of high blood pressure in pregnancy-associated hypertensive mice.

    PubMed

    Murata, Kazuya; Baasanjav, Altansarnai; Kwon, Chulwon; Hashimoto, Misuzu; Ishida, Junji; Fukamizu, Akiyoshi

    2015-09-01

    Angiotensin II (AngII) is a vasopressor hormone that has critical roles in maintenance of normal blood pressure and pathogenesis of cardiovascular diseases. We previously generated pregnancy-associated hypertensive (PAH) mice by mating female human angiotensinogen transgenic mice with male human renin transgenic mice. PAH mice exhibit hypertension in late pregnancy by overproducing AngII. A recent study demonstrated that angiotensin II type I (AT1) receptor is expressed in mammary epithelial cells and its signaling is critical for mammary gland involution after weaning. However, the role of AngII-AT1 receptor signaling in the development of mammary gland during pregnancy remains unclear. In this study, to investigate the role of AngII-AT1 receptor signaling in mammary gland development during pregnancy, we analyzed the mammary gland of PAH mice. Histological and gene expression analyses revealed that lobuloalveolar development was accelerated with increased milk protein production and lipid accumulation in the mammary gland of PAH mice. Furthermore, AT1 receptor blocker treatment suppressed acceleration of mammary gland development in PAH mice, while the treatment of hydralazine, another antihypertensive drug, did not. These data suggest that AngII-AT1 receptor-induced signaling accelerates mammary gland development during pregnancy through hypertension-independent mechanism.

  4. Research and development for electropolishing of Nb for ILC accelerator cavities

    SciTech Connect

    Kelley, Michael J.

    2009-09-21

    The objectives of this project are to 1, Expand the scientific and technological understanding of the effect of post-treatment (electropolish, buffered chemical polish, low-temperature baking) on the surface of niobium; 2, Relate the knowledge to the performance of niobium superconducting radiofrequency accelerator cavities; and, 3, Thereby design and demonstrate an electropolish process that can be applied to complete cavities.

  5. Development and testing of the improved focusing quadrupole for heavy ion fusion accelerators

    SciTech Connect

    Manahan, R R; Martovetsky, N N; Meinke, R B; Chiesa, L; Lietzke, A F; Sabbi, G L; Seidl, P A

    2003-10-23

    An improved version of the focusing magnet for a Heavy Ion Fusion (HIF) accelerator was designed, built and tested in 2002-2003. This quadrupole has higher focusing power and lower error field than the previous version of the focusing quadrupoles successfully built and tested in 2001. We discuss the features of the new design, selected fabrication issues and test results.

  6. DEVELOPMENT OF ACCELERATOR DATA REPORTING SYSTEM AND ITS APPLICATION TO TREND ANALYSIS OF BEAM CURRENT DATA

    SciTech Connect

    Padilla, M.J.; Blokland, W.

    2009-01-01

    Detailed ongoing information about the ion beam quality is crucial to the successful operation of the Spallation Neutron Source at Oak Ridge National Laboratory. In order to provide the highest possible neutron production time, ion beam quality is monitored to isolate possible problems or performance-related issues throughout the accelerator and accumulator ring. For example, beam current monitor (BCM) data is used to determine the quality of the beam transport through the accelerator. In this study, a reporting system infrastructure was implemented and used to generate a trend analysis report of the BCM data. The BCM data was analyzed to facilitate the identifi cation of monitor calibration issues, beam trends, beam abnormalities, beam deviations and overall beam quality. A comparison between transformed BCM report data and accelerator log entries shows promising results which represent correlations between the data and changes made within the accelerator. The BCM analysis report is one of many reports within a system that assist in providing overall beam quality information to facilitate successful beam operation. In future reports, additional data manipulation functions and analysis can be implemented and applied. Built-in and user-defi ned analytic functions are available throughout the reporting system and can be reused with new data.

  7. Development of millimeter-wave accelerating structures using precision metal forming technology

    SciTech Connect

    2003-06-03

    High gradients in radio-frequency (RF) driven accelerators require short wavelengths that have the concomitant requirements of small feature size and high tolerances, 1-2 {micro}m for millimeter wavelengths. Precision metal-forming stampling has the promise of meeting those tolerances with high production rates. This STI will evaluate that promise.

  8. Developing high energy, stable laser wakefield accelerators: particle simulations and experiments

    NASA Astrophysics Data System (ADS)

    Geddes, Cameron

    2006-10-01

    Laser driven wakefield accelerators produce accelerating fields thousands of times those achievable in conventional radiofrequency accelerators, and recent experiments have produced high energy electron bunches with low emittance and energy spread. Challenges now include control and reproducibility of the electron beam, further improvements in energy spread, and scaling to higher energies. We present large-scale particle in cell simulations together with recent experiments towards these goals. In LBNL experiments the relativistically intense drive pulse was guided over more than 10 diffraction ranges by plasma channels. Guiding beyond the diffraction range improved efficiency by allowing use of a smaller laser spot size (and hence higher intensities) over long propagation distances. At a drive pulse power of 9 TW, electrons were trapped from the plasma and beams of percent energy spread containing > 200pC charge above 80 MeV with normalized emittance estimated at < 2 π-mm-mrad were produced. Energies have now been scaled to 1 GeV using 40 TW of laser power. Particle simulations and data showed that the high quality bunch in recent experiments was formed when beam loading turned off injection after initial self trapping, creating a bunch of electrons isolated in phase space. A narrow energy spread beam was then obtained by extracting the bunch as it outran the accelerating phase of the wake. Large scale simulations coupled with experiments are now under way to better understand the optimization of such accelerators including production of reproducible electron beams and scaling to energies beyond a GeV. Numerical resolution and two and three dimensional effects are discussed as well as diagnostics for application of the simulations to experiments. Effects including injection and beam dynamics as well as pump laser depletion and reshaping will be described, with application to design of future experiments. Supported by DOE grant DE-AC02-05CH11231 and by an INCITE

  9. A critical point of male gonad development: neuroendocrine correlates of accelerated testicular growth in rats during early life.

    PubMed

    Dygalo, Nikolay N; Shemenkova, Tatjana V; Kalinina, Tatjana S; Shishkina, Galina T

    2014-01-01

    Testis growth during early life is important for future male fertility and shows acceleration during the first months of life in humans. This acceleration coincides with the peak in gonadotropic hormones in the blood, while the role of hypothalamic factors remains vague. Using neonatal rats to assess this issue, we found that day 9 of life is likely critical for testis development in rats. Before this day, testicular growth was proportional to body weight gain, but after that the testes showed accelerated growth. Hypothalamic kisspeptin and its receptor mRNA levels begin to elevate 2 days later, at day 11. A significant increase in the mRNA levels for gonadotropin-releasing hormone (GnRH) receptors in the hypothalamus between days 5 and 7 was followed by a 3-fold decrease in GnRH mRNA levels in this brain region during the next 2 days. Starting from day 9, hypothalamic GnRH mRNA levels increased significantly and positively correlated with accelerated testicular growth. Triptorelin, an agonist of GnRH, at a dose that had no effect on testicular growth during "proportional" period, increased testis weights during the period of accelerated growth. The insensitivity of testicular growth to GnRH during "proportional" period was supported by inability of a 2.5-fold siRNA knockdown of GnRH expression in the hypothalamus of the 7-day-old animals to produce any effect on their testis weights. GnRH receptor blockade with cetrorelix was also without effect on testis weights during "proportional" period but the same doses of this GnRH antagonist significantly inhibited "accelerated" testicular growth. GnRH receptor mRNA levels in the pituitary as well as plasma LH concentrations were higher during "accelerated" period of testicular growth than during "proportional" period. In general, our data defined two distinct periods in rat testicular development that are primarily characterized by different responses to GnRH signaling.

  10. Accelerator-Based Boron Neutron Capture Therapy and the Development of a Dedicated Tandem-Electrostatic-Quadrupole

    SciTech Connect

    Kreiner, A. J.; Di Paolo, H.; Burlon, A. A.; Valda, A. A.; Debray, M. E.; Somacal, H. R.; Minsky, D. M.; Kesque, J. M.; Giboudot, Y.; Levinas, P.; Fraiman, M.; Romeo, V.

    2007-10-26

    There is a generalized perception that the availability of suitable particle accelerators installed in hospitals, as neutron sources, may be crucial for the advancement of Boron Neutron Capture Therapy (BNCT). Progress on an ongoing project to develop a Tandem-ElectroStatic-Quadrupole (TESQ) accelerator for Accelerator-Based (AB)-BNCT is described here. The project goal is a machine capable of delivering 30 mA of 2.5 MeV protons to be used in conjunction with a neutron production target based on the {sup 7}Li(p,n){sup 7}Be reaction slightly beyond its resonance at 2.25 MeV. A folded tandem, with 1.25 MV terminal voltage, combined with an ESQ chain is being designed and constructed. A 30 mA proton beam of 2.5 MeV are the specifications needed to produce sufficiently intense and clean epithermal neutron beams, based on the {sup 7}Li(p,n){sup 7}Be reaction, to perform BNCT treatment for deep-seated tumors in less than an hour. The first design and construction of an ESQ module is discussed and its electrostatic fields are investigated theoretically and experimentally. Also new beam transport calculations through the accelerator are presented.

  11. The Evolutionary Dynamics of Education Systems: Exposition on Institutional Development. International Commission on Education for the Twenty-First Century, Second Session (Dakar, Senegal, September 18-22, 1993).

    ERIC Educational Resources Information Center

    Carneiro, Roberto

    This paper analyzes the stages of educational development beginning in the 1950s and 1960s, when mass economies began to emerge, immediately after World War II. This essay covers the last 40 years that have been characterized by rapid change and the most fascinating acceleration in the history of humanity. During those four decades, education…

  12. Progress towards the development of transient ram accelerator simulation as part of the U.S. Air Force Armament Directorate Research Program

    NASA Astrophysics Data System (ADS)

    Sinha, N.; York, B. J.; Dash, S. M.; Drabczuk, R.; Rolader, G. E.

    1992-07-01

    This paper describes the development of an advanced CFD simulation capability in support of the U.S. Air Force Armament Directorate's ram accelerator research initiative. The state-of-the-art CRAFT computer code has been specialized for high fidelity, transient ram accelerator simulations via inclusion of generalized dynamic gridding, solution adaptive grid clustering, high pressure thermochemistry, etc. Selected ram accelerator simulations are presented which serve to exhibit the CRAFT code's capabilities and identify some of the principal research/design issues.

  13. PARTICLE ACCELERATOR

    DOEpatents

    Teng, L.C.

    1960-01-19

    ABS>A combination of two accelerators, a cyclotron and a ring-shaped accelerator which has a portion disposed tangentially to the cyclotron, is described. Means are provided to transfer particles from the cyclotron to the ring accelerator including a magnetic deflector within the cyclotron, a magnetic shield between the ring accelerator and the cyclotron, and a magnetic inflector within the ring accelerator.

  14. A small scale accelerator driven subcritical assembly development and demonstration experiment at LAMPF

    SciTech Connect

    Wender, S. A.; Venneri, F.; Bowman, C. D.; Arthur, E. D.; Heighway, E.; Beard, C. A.; Bracht, R. R.; Buksa, J. J.; Chavez, W.; DeVolder, B. G.; Park, J. J.; Parker, R. B.; Pillai, C.; Pitcher, E.; Potter, R. C.; Reid, R. S.; Russell, G. J.; Trujillo, D. A.; Weinacht, D. J.; Wilson, W. B.

    1995-09-15

    A small scale experiment is described that will demonstrate many of the aspects of accelerator-driven transmutation technology. This experiment uses the high-power proton beam from the Los Alamos Meson Physics Facility accelerator and will be located in the Area-A experimental hall. Beam currents of up to 1 mA will be used to produce neutrons with a molten lead target. The target is surrounded by a molten salt and graphite moderator blanket. Fissionable material can be added to the molten salt to demonstrate plutonium burning or transmutation of commercial spent fuel or energy production from thorium. The experiment will be operated at power levels up to 5 MWt.

  15. Recent Developments on ALICE (Accelerators and Lasers In Combined Experiments) at Daresbury Laboratory

    SciTech Connect

    Saveliev, Y M; Buckley, R K; Buckley, S R; Clarke, J A; Corlett, P A; Dunning, D J; Goulden, A R; Hill, S F; Jackson, F; Jamison, S P; Jones, J K; Jones, L B; Leonard, S; McIntosh, P A; McKenzie, J W; Middleman, K J; Militsyn, B L; Moss, A J; Muratori, B D; Orrett, J F; Pattalwar, S M; Phillips, P J; Scott, D J; Seddon, E A; Shepherd, B.J.A.; Smith, S L; Thompson, N; Wheelhouse, A E; Williams, P H; Harrison, P; Holder, D J; Holder, G M; Schofield, A L; Weightman, P; Williams, R L; Laundry, D; Powers, T; Priebe, G; Surman, M

    2010-05-01

    Progress made in ALICE (Accelerators and Lasers In Combined Experiments) commissioning and a summary of the latest experimental results are presented in this paper. After an extensive work on beam loading effects in SC RF linac (booster) and linac cavities conditioning, ALICE can now operate in full energy recovery mode at the bunch charge of 40pC, the beam energy of 30MeV and train lengths of up to 100us. This improved operation of the machine resulted in generation of coherently enhanced broadband THz radiation with the energy of several tens of uJ per pulse and in successful demonstration of the Compton Backscattering x-ray source experiment. The next steps in the ALICE scientific programme are commissioning of the IR FEL and start of the research on the first non-scaling FFAG accelerator EMMA. Results from both projects will be also reported.

  16. Session 3 in ACAT05

    NASA Astrophysics Data System (ADS)

    Fujimoto, J.

    2006-04-01

    Activities in Session 3 of AIHENP/ACAT series are reviewed. In the perturbative approaches in high energy physics, this session keeps a special position among several similar other workshops because it deals with the massive usage of computers and/or artificial intelligence, not only physics consequences. In this edition of the series there appear in addition two new topics on the lattice QCD and the quantum computation.

  17. 77 FR 60373 - Board of Directors Executive Session Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-03

    ...; ] AFRICAN DEVELOPMENT FOUNDATION Board of Directors Executive Session Meeting Meeting: African Development..., October 11, 2012, 5 p.m. to 6:30 p.m. Lloyd O. Pierson, President & CEO, United States African...

  18. Development and analysis of a metal-fueled accelerator-driven burner

    SciTech Connect

    Lypsch, F.; Hill, R.N.

    1994-08-01

    The purpose of this paper is to compare the safety characteristics of an accelerator driven metal fueled fast system to a critical core on a consistent basis to determine how these characteristics are affected solely by subcritically of the system. To accomplish this an accelerator proton beam/tungsten neutron source model is surrounded by a subcritical blanket using metallic fuel and sodium as coolant. The consequences of typical accident transients, namely unprotected transient overpower (TOP), loss of heat sink (LOHS), and loss of flow (LOP) were calculated for the hybrid system and compared to corresponding results for a metal-fueled fast reactor. Results indicate that the subcritical system exhibits superior performance for TOP (reactivity-induced) transits; however, only in the critical system are reactivity feedbacks able to cause passive shutdown in the LOHS ad LOP events. Therefore, for a full spectrum of accident initiators considered, the overall safety behavior of accelerator-driven metal-fueled systems can neither be concluded to be worse nor to be better than advanced reactor designs which rely on passive safety features.

  19. Recent progress in the development of a circular ion induction accelerator for space charge dominated beams at LLNL

    SciTech Connect

    Ahle, L; Autrey, D; Barnard, J; Berners, D; Craig, G; Debeling, A; Eylon, S; Friedman, A; Fritz, W; Grote, D P; Halaxa, E; Hanks, R L; Hernandez, M; Judd, D L; Kirbie, H C; Logan, B G; Lund, S M; Mant, G; Molvik, A W; Reginato, L; Sangster, T C; Sharp, W M

    1998-08-19

    The Heavy Ion Fusion Group at Lawrence Livermore National Laboratory has for several years been developing the world's first circular ion induction accelerator. This machine has recently been extended to 90 degrees, or 10 half-lattice periods (HLP) with full beam transport. In addition, induction cores have been installed on five of the HLP's, each with an independent arbitrary waveform pulser. An arbitrary waveform pulser for the bending electrostatic dipoles has also been enabled. Together, they have allowed the first attempts at coordinated bending and acceleration of the beam. The results of these first attempts will be reported on in the paper by examining the output of various diagnostic devices, such as the capacitive Beam Probes (C-probes), slit scanners, and the Gated Beam Imager(GBI).

  20. Session: Parabolic Troughs (Presentation)

    SciTech Connect

    Kutscher, C.

    2008-04-01

    The project description is R and D activities at NREL and Sandia aimed at lowering the delivered energy cost of parabolic trough collector systems and FOA awards to support industry in trought development. The primary objectives are: (1) support development of near-term parabolic trought technology for central station power generation; (2) support development of next-generation trought fields; and (3) support expansion of US trough industry. The major FY08 activities were: (1) improving reflector optics; (2) reducing receiver heat loss (including improved receiver coating and mitigating hydrogen accumulation); (3) measuring collector optical efficiency; (4) optimizing plant performance and reducing cost; (5) reducing plant water consumption; and (6) directly supporting industry needs, including FOA support.

  1. Expert system for scheduling simulation lab sessions

    NASA Technical Reports Server (NTRS)

    Lund, Chet

    1990-01-01

    Implementation and results of an expert system used for scheduling session requests for the Systems Engineering Simulator (SES) laboratory at the NASA Johnson Space Center (JSC) are discussed. Weekly session requests are received from astronaut crew trainers, procedures developers, engineering assessment personnel, software developers, and various others who wish to access the computers, scene generators, and other simulation equipment available to them in the SES lab. The expert system under discussion is comprised of a data acquisition portion - two Pascal programs run on a personal computer - and a CLIPS program installed on a minicomputer. A brief introduction to the SES lab and its scheduling background is given. A general overview of the system is provided, followed by a detailed description of the constraint-reduction process and of the scheduler itself. Results from a ten-week trial period using this approach are discussed. Finally, a summary of the expert system's strengths and shortcomings are provided.

  2. Accelerator Technology Division

    NASA Astrophysics Data System (ADS)

    1992-04-01

    In fiscal year (FY) 1991, the Accelerator Technology (AT) division continued fulfilling its mission to pursue accelerator science and technology and to develop new accelerator concepts for application to research, defense, energy, industry, and other areas of national interest. This report discusses the following programs: The Ground Test Accelerator Program; APLE Free-Electron Laser Program; Accelerator Transmutation of Waste; JAERI, OMEGA Project, and Intense Neutron Source for Materials Testing; Advanced Free-Electron Laser Initiative; Superconducting Super Collider; The High-Power Microwave Program; (Phi) Factory Collaboration; Neutral Particle Beam Power System Highlights; Accelerator Physics and Special Projects; Magnetic Optics and Beam Diagnostics; Accelerator Design and Engineering; Radio-Frequency Technology; Free-Electron Laser Technology; Accelerator Controls and Automation; Very High-Power Microwave Sources and Effects; and GTA Installation, Commissioning, and Operations.

  3. Proof-of-concept development of PXAMS (projectile x-ray accelerator mass spectrometry)

    SciTech Connect

    Proctor, I.D.; Roberts, M.L.; McAninch, J.E.; Bench, G.S.

    1996-03-01

    Prior to the current work, accelerator mass spectrometry (AMS) was limited to a set of {approximately}8--10 isotopes. This limitation is caused primarily by the inability to discriminate against stable atomic isobars. An analysis scheme that combines the isotopic sensitivity of AMS with similar isobar selectivity would open a large new class of isotope applications. This project was undertaken to explore the use of characteristic x rays as a method for the detection and identification of ions,and to allow the post-spectrometer rejection of isobaric interferences for isotopes previously inaccessible to AMS. During the second half of FY94 (with Advanced Concepts funding from the Office of Non-Proliferation and National Security), we examined the feasability of this technique, which we are referring to as PXAMS (Projectile X ray AMS), to the detection of several isotopes at Lawrence Livermore National Laboratory (LLNL). In our first exploratory work, we measured the x ray yield vs energy for {sup 80}Se ions stopped in a thick Y target. These results, demonstrated that useful detection efficiencies could be obtained for Se ions at energies accessible with our accelerator, and that the count rate from target x rays is small compared to the Se K{alpha} rate. We followed these measurements with a survey of x ray yields for Z = 14-46.

  4. Development and Use of Life-Cycle Analysis Capabilites To Evaluate, Select, and Implement Plans to Accelerate Hanford Site Cleanup

    SciTech Connect

    Shay, Michael R.; Johnson, Wayne L.; Frey, Jeffrey A.

    2004-02-28

    Over the past year the U.S. Department of Energy (DOE) has made significant progress in developing and executing plans to transform and accelerate cleanup of the Hanford Site. Notable progress has been in the cleanup of the River Corridor, including the relocation of spent nuclear fuel to the Central Plateau, and the stabilization of plutonium materials. However, difficult work still remains. DOE has already accelerated the completion of the Environmental Management (EM) cleanup mission from 2070 to 2035 and believes its completion can be achieved even sooner by reducing excess conservatism, substantively changing technical strategy and management approach, and making new front-end investments. Work is well under way in the detailed planning, analyses and decision making required to implement and support the execution of the accelerated cleanup program at Hanford. Various cleanup, contract, and regulatory approaches are being explored. DOE has instituted a process that allows DOE to efficiently explore and test alternative cleanup approaches using a life-cycle model. This paper provides a means to share the planning approach and the life-cycle modeling and analysis tools used with other sites and interested parties. This paper will be of particular interest to analysts performing similar planning and evaluations at other sites as well as provide insight into the current status of Hanford’s cleanup program and DOE’s plans for the future.

  5. Using combinatorial bioinformatics methods to analyze annual perspective changes of influenza viruses and to accelerate development of effective vaccines.

    PubMed

    Hu, Yu-Jen; Chow, Kuan-Chih; Liu, Ching-Chuan; Lin, Li-Jen; Wang, Sheng-Cheng; Wang, Shulhn-Der

    2015-08-01

    The standard World Health Organization procedure for vaccine development has provided a guideline for influenza viruses, but no systematic operational model. We recently designed a systemic analysis method to evaluate annual perspective sequence changes of influenza virus strains. We applied dnaml of PHYLIP 3.69, developed by Joseph Felsenstein of Washington University, and ClustalX2, developed by Larkin et al, for calculating, comparing, and localizing the most plausible vaccine epitopes. This study identified the changes in biological sequences and associated alignment alterations, which would ultimately affect epitope structures, as well as the plausible hidden features to search for the most conserved and effective epitopes for vaccine development. Addition our newly designed systemic analysis method to supplement the WHO guidelines could accelerate the development of urgently needed vaccines that might concurrently combat several strains of viruses within a shorter period.

  6. Wrap-up session

    NASA Technical Reports Server (NTRS)

    Holland, Geoffrey

    1992-01-01

    Listening to the case studies that were presented it became quite evident that the best data management systems were the ones where data managers and research scientists worked as a team developed in the early stages of project planning. Examples that were given included WOCE Data Assembly Centres e.g., Drifters, the Global Temperature Salinity Pilot Project (GTSPP) collaboration with Joint Analyses Centres in the U.S. and Australia, and JGOFS/BOFS development of Topical Centres. While each of these has some elements unique to the project, each had brought together 'teams' of Principal Investigators (PI's) and data management experts at an early stage of project development. Conversely, projects which had considered data management as a totally separate activity with lower priority often failed to provide the service required to meet scientific objectives. Therefore, the following actions should be brought to the attention of relevant groups within the IOC and other international organizations: (1) Publicize, at the national and international level, underway data/scientist collaborations that may be used as models in planning for the future. (2) Reduce adversarial situations where data managers and scientists appear to be in competition. (3) Colocation and other forms of collaboration often results in very high quality data sets and more timely data submission. Improved timeliness of data submissions was a common theme throughout the workshop and must be considered an important element in all future plans. Improvements in timely submission of data were noted. In order to continue this trend the advantages of timely submission of data must be stressed to those planning new ocean science projects.

  7. Final Plenary Session Transcript

    NASA Technical Reports Server (NTRS)

    Gostelow, Paul

    2010-01-01

    Let s start with the report - as you know - when we are talking about flow control it is a multi-disciplinary type of work. So it involves many people and disciplines. This group first discussed the important issues associated with flow control. As you start doing flow control what are the issues to which you really have to start paying attention? That is the first part I am going to present. Then in the second part I will present some challenges - problems that we should really be looking at. So as far as the issues - if you want to control a flow, you really need to understand the flow physics, because anything that you do comes from the flow physics. The design of the controllers, your decisions on the actuators, sensors, reduced order modeling and all of that, would be helped if you understand flow physics. And you have to have a specific objective - what exactly are you controlling? Are you trying to reduce drag, eliminate separation, reduce noise, enhance mixing? So you have to have very specific control objectives. From all the talks we have seen here actuation is extremely important and it is very problem specific. It depends on what problem you are dealing with so you have to design and build actuators for that specific problem. Sensors obviously are very important, especially when you are dealing with feedback control. Consensus was that when you dealing with flow control, you must take an integrated approach; from the beginning you have to take into account every aspect of it and even maybe to modify your experiment, your geometry, to go along with the actuation, sensors and control models. Development of tools is very important in this multi-disciplinary problem. The tools include CFD, reduced order modeling, controller design, understanding and utilizing the instabilities of the flow, etc. So, in order to have success in flow control, we really need to develop these tools.

  8. Development of a synchrotron radiation beam monitor for the Integrable Optics Test Accelerator

    SciTech Connect

    Scarpelli, Andrea

    2016-01-01

    Nonlinear integrable optics applied to beam dynamics may mitigate multi-particle instabilities, but proof of principle experiments have never been carried out. The Integrable Optics Test Accelerator (IOTA) is an electron and proton storage ring currently being built at Fermilab, which addresses tests of nonlinear lattice elements in a real machine in addition to experiments on optical stochastic cooling and on the single-electron wave function. These experiments require an outstanding control over the lattice parameters, achievable with fast and precise beam monitoring systems. This work describes the steps for designing and building a beam monitor for IOTA based on synchrotron radiation, able to measure intensity, position and transverse cross-section beam.

  9. Interactive TV on parliament session

    NASA Astrophysics Data System (ADS)

    Royer, J.; Nguyen, H.; Martinot, O.; Preda, M.; Preteux, F.; Zaharia, T.

    2007-09-01

    This paper introduces a new interactive mobile TV application related to parliament session. This application aims to provide additional information to mobile TV users by inserting automatically and in real-time interactive contents (complementary information, subject of the current session...) into original TV program, using MPEG-4 streaming video and extra real time information (news, events, databases... from RSS streams, Internet links...). Here, we propose an architecture based on plug-in multimedia analyzers to generate the contextual description of the media and on an interactive scene generator to dynamically create related interactive scenes. Description is implemented according to the MPEG-7 standard.

  10. IMC9 Edinburgh Nomenclature Sessions.

    PubMed

    Norvell, Lorelei L; Hawksworth, David L; Petersen, Ronald H; Redhead, Scott A

    2010-12-01

    The proceedings of the 3-5 August 2010, IMC9 Edinburgh Nomenclature Sessions are briefly summarized. The final resolution approved by the General Assembly endorses the recommendations by the Nomenclature Sessions regarding transfer of the governance of fungal nomenclature from botanical to mycological congresses, mandatory pre-publication deposit of nomenclatural information for valid publication of new fungal names, and the acceptability of English as an alternative to Latin in the valid publication of fungal names. Complete results from the IMC9 nomenclature questionnaire are also provided.

  11. Critical moments in time: reflections on the development of orthogonal acceleration time-of-flight mass spectrometry.

    PubMed

    Sheil, Margaret M

    2012-08-01

    This paper reflects on the historical development of orthogonal acceleration time-of-flight analyzers that have been used routinely for high sensitivity analyses of biological molecules for more than a decade. In particular, the role of the late Michael Guilhaus from the University of New South Wales in Australia is highlighted. This account shows that like most advances in science, successful commercialization of new technology is not straightforward and is often the result of critical contributions of different people and organizations at different points in time.

  12. Rural Development Act of 1972: Report Together with Additional and Individual Views [To Accompany S. 3462]. 92d Congress, 2d Session, April 7, 1972.

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. Senate Committee on Agriculture, Nutrition, and Forestry.

    Submitted to the U.S. Senate by the Committee on Agriculture and Forestry, this report on the Rural Development Act of 1972 contains the following: (1) Brief Explanation of the Bill (Titles I-VII); (2) Statements on the Need for Rural Development and Rural Development Credit and Investment; (3) Titles I-VII (presented via a short explanation, a…

  13. Upgrade of the MIT Linear Electrostatic Ion Accelerator (LEIA) for nuclear diagnostics development for Omega, Z and the NIF.

    PubMed

    Sinenian, N; Manuel, M J-E; Zylstra, A B; Rosenberg, M; Waugh, C J; Rinderknecht, H G; Casey, D T; Sio, H; Ruszczynski, J K; Zhou, L; Gatu Johnson, M; Frenje, J A; Séguin, F H; Li, C K; Petrasso, R D; Ruiz, C L; Leeper, R J

    2012-04-01

    The MIT Linear Electrostatic Ion Accelerator (LEIA) generates DD and D(3)He fusion products for the development of nuclear diagnostics for Omega, Z, and the National Ignition Facility (NIF). Significant improvements to the system in recent years are presented. Fusion reaction rates, as high as 10(7) s(-1) and 10(6) s(-1) for DD and D(3)He, respectively, are now well regulated with a new ion source and electronic gas control system. Charged fusion products are more accurately characterized, which allows for better calibration of existing nuclear diagnostics. In addition, in situ measurements of the on-target beam profile, made with a CCD camera, are used to determine the metrology of the fusion-product source for particle-counting applications. Finally, neutron diagnostics development has been facilitated by detailed Monte Carlo N-Particle Transport (MCNP) modeling of neutrons in the accelerator target chamber, which is used to correct for scattering within the system. These recent improvements have resulted in a versatile platform, which continues to support the existing nuclear diagnostics while simultaneously facilitating the development of new diagnostics in aid of the National Ignition Campaign at the National Ignition Facility.

  14. An Lck-cre transgene accelerates autoantibody production and lupus development in (NZB × NZW)F1 mice.

    PubMed

    Nelson, R K; Gould, K A

    2016-02-01

    Lupus is an autoimmune disease characterized by the development of antinuclear autoantibodies and immune complex-mediated tissue damage. T cells in lupus patients appear to undergo apoptosis at an increased rate, and this enhanced T cell apoptosis has been postulated to contribute to lupus pathogenesis by increasing autoantigen load. However, there is no direct evidence to support this hypothesis. In this study, we show that an Lck-cre transgene, which increases T cell apoptosis as a result of T cell-specific expression of cre recombinase, accelerates the development of autoantibodies and nephritis in lupus-prone (NZB × NZW)F1 mice. Although the enhanced T cell apoptosis in Lck-cre transgenic mice resulted in an overall decrease in the relative abundance of splenic CD4(+) and CD8(+) T cells, the proportion of activated CD4(+) T cells was increased and no significant change was observed in the relative abundance of suppressive T cells. We postulate that the Lck-cre transgene promoted lupus by enhancing T cell apoptosis, which, in conjunction with the impaired clearance of apoptotic cells in lupus-prone mice, increased the nuclear antigen load and accelerated the development of anti-nuclear autoantibodies. Furthermore, our results also underscore the importance of including cre-only controls in studies using the cre-lox system.

  15. Introduction to Session 1A

    NASA Astrophysics Data System (ADS)

    Himmel, Michael E.

    Understanding and overcoming the natural resistance of plant cell walls to enzymatic hydrolysis remains one of the most active research areas in biofuels production (as indicated by the number of abstracts and papers submitted to this session). A number of the oral presentations given during the Enzyme Catalysis and Engineering session highlighted the use of new and innovative tools for advancing our understanding of plant cell wall deconstruction. The oral presentations and posters given for this session included applications of imaging tools and computational models to advance our understanding of biomass recalcitrance relative to enzymatic deconstruction. This session was opened with a presentation by Dr. Danny Akin, who outlined the structural and chemical barriers for the bioconversion of grasses to sugars. Lignocelluloses from grasses, such as switch grass, are resistant to bioconversion by various aromatic constituuents, which include both lignins and phenolic acid esters. However, Akin and coworkers demonstrated the use of selected white rot fungal enzymes, which lack cellulases that could be used to produce delignified lignocellulosic materials, resulting in improved bioconversion.

  16. Online Training Sessions: Suggested Guidelines.

    ERIC Educational Resources Information Center

    Cabonell, Martha; And Others

    1981-01-01

    These planning and evaluative guidelines for online trainers utilize a sliding scale--from minimal to suggested to optimal--for five types of training sessions: (1) Search Service--Beginning; (2) Search Service--Advanced; (3) Search Service--Subject; (4) Database Producer; and (5) Independent Introductory Workshop. (RAA)

  17. Developments in Theater Level War Games. Materials for the C-5 Working Group ’Gaming and Simulation, of the 35th Session of the Military Operations Research Society

    DTIC Science & Technology

    1974-12-01

    modify parameters influencing the tactical decision logic, or influence the allocation of tactical air resources. 3 3 .-3 TH T CORPORATION 1920 Aline...theater level models is ATLAS, developed by the Research Analysis Corporation for the Army (6). The following general description of ATLAS is taken...0 167 63 p.. TITLE: CEM* - CONAF Evaluation Model PROPONENT: U. S. Army Combat Developments Command DEVELOPER: Research Analysis Corporation PURPOSE

  18. Semi-Automated Discovery of Application Session Structure

    SciTech Connect

    Kannan, J.; Jung, J.; Paxson, V.; Koksal, C.

    2006-09-07

    While the problem of analyzing network traffic at the granularity of individual connections has seen considerable previous work and tool development, understanding traffic at a higher level---the structure of user-initiated sessions comprised of groups of related connections---remains much less explored. Some types of session structure, such as the coupling between an FTP control connection and the data connections it spawns, have prespecified forms, though the specifications do not guarantee how the forms appear in practice. Other types of sessions, such as a user reading email with a browser, only manifest empirically. Still other sessions might exist without us even knowing of their presence, such as a botnet zombie receiving instructions from its master and proceeding in turn to carry them out. We present algorithms rooted in the statistics of Poisson processes that can mine a large corpus of network connection logs to extract the apparent structure of application sessions embedded in the connections. Our methods are semi-automated in that we aim to present an analyst with high-quality information (expressed as regular expressions) reflecting different possible abstractions of an application's session structure. We develop and test our methods using traces from a large Internet site, finding diversity in the number of applications that manifest, their different session structures, and the presence of abnormal behavior. Our work has applications to traffic characterization and monitoring, source models for synthesizing network traffic, and anomaly detection.

  19. Women in Development: Looking to the Future. Hearing before the Committee on Foreign Relations. United States Senate, Ninety-Eighth Congress, Second Session.

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. Senate.

    In this Congressional hearing witnesses explored the roles of government, private agencies, the media, public education, business, and labor in contributing to the further enhancement of the role of women in the economic development of the Third World. Government witnesses were M. Peter McPherson, Agency for International Development and Nancy…

  20. The Comprehensive Child Development Centers Act. Report from the Committee on Labor and Human Resources (To Accompany S. 1542). 100th Congress, 1st Session.

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. Senate Committee on Labor and Human Resources.

    This report of the Committee on Labor and Human Resources recommends that the Senate pass the Comprehensive Child Development Centers Act of 1987, S. 1542. The bill amends the Head Start Act to provide for the establishment of several child development centers designed to encourage supportive services for infants and young children from low income…

  1. H. R. 3899: a bill to establish a hydrogen research and development program. Introduced in the House of Representatives, Ninety-Ninth Congress, First Session, December 11, 1985

    SciTech Connect

    Not Available

    1985-01-01

    The Hydrogen Research and Development Act (H.R. 3899) recognizes both the importance of developing alternatives for petroleum fuels that have a universal availability and the promise of hydrogen, the most abundant element, to serve this need. Attributes of hydrogen besides ready availability and economics include ease of transport, the capacity for conversion to high quality feedstock and fuels, and the integral role of hydrogenation in synfuels production. The bill calls for the DOE to develop a comprehensive management plan to implement and coordinate research and development and to pursue technical applications. Funding is set at $200 million, with $25 million authorized for fiscal year 1987. Title II deals with research, development, and flight demonstration of hydrogen-fueled aircraft. The funding for that is set at $75 million, with $10 million authorized for 1987.

  2. Accelerated nervous system development contributes to behavioral efficiency in the laboratory mouse: a behavioral review and theoretical proposal.

    PubMed

    Whishaw, I Q; Metz, G A; Kolb, B; Pellis, S M

    2001-11-01

    The emergence of the laboratory mouse as a favored species for genetic research has posed a number of problems for scientists interested in the reflection of genetic influences in mouse behavior. It is commonly thought that rat behavior, which has been studied more extensively than mouse behavior, could be easily generalized to mice. In this article, a number of categories of behavior displayed by the mouse (motor, spatial, defensive, social) are reviewed and contrasted with the same categories of behavior displayed by the rat. The comparison suggests that mouse behavior is simpler and more dependent upon elementary actions than the behavior of the rat. We suggest that the behavioral simplification in the mouse adapts it for a different ecological niche than that occupied by the rat. We propose that this simplification may be mediated by accelerated brain maturation during development. We further propose that this developmental acceleration in the mouse renders it less dependent upon complex social behavior and plastic nervous system changes associated with learning than the rat. This difference poses problems for the development of relevant methods of behavioral analysis and interpretation. Since the mouse's biological adaptations will be reflected in laboratory behavior, suggestions are made for behavioral approaches to the study and interpretation of mouse behavior.

  3. Plasma-based accelerator structures

    SciTech Connect

    Schroeder, Carl B.

    1999-12-01

    Plasma-based accelerators have the ability to sustain extremely large accelerating gradients, with possible high-energy physics applications. This dissertation further develops the theory of plasma-based accelerators by addressing three topics: the performance of a hollow plasma channel as an accelerating structure, the generation of ultrashort electron bunches, and the propagation of laser pulses is underdense plasmas.

  4. Operational Assessment of Tools for Accelerating Leader Development (ALD): Volume 2, Appendices

    DTIC Science & Technology

    2009-06-01

    collection Fence time and resources for full website development; mobilize qualified experts to develop website; perform interim checks of website ... design and functionality. Website functionality is requirement for pilot test and to implement the demonstration. Failure to operationally test

  5. Accelerated development of chronic lymphocytic leukemia in New Zealand Black mice expressing a low level of interferon regulatory factor 4.

    PubMed

    Ma, Shibin; Shukla, Vipul; Fang, Leilei; Gould, Karen A; Joshi, Shantaram S; Lu, Runqing

    2013-09-13

    A recent genome-wide SNP association study identified IRF4 as a major susceptibility gene for chronic lymphocytic leukemia (CLL). Moreover, the SNPs located in the 3' UTR of the IRF4 gene have been linked to a down-regulation of IRF4. However, whether a low level of IRF4 is critical for CLL development remains unclear. New Zealand Black (NZB) mice are a naturally occurring, late-onset mouse model of CLL. To examine the role of a reduced level of IRF4 in CLL development, we generated, through breeding, IRF4 heterozygous mutant mice in the NZB background (NZB IRF4(+/-)). Our results show that CLL development is accelerated dramatically in the NZB IRF4(+/-) mice. The average onset of CLL in NZB mice is 12 months, but CLL cells can be detected in NZB IRF4(+/-) mice at 3 months of age. By 5 months of age, 80% of NZB IRF4(+/-) mice developed CLL. CLL cells are derived from B1 cells in mice. Interestingly, NZB IRF4(+/-) B1 cells exhibit prolonged survival, accelerated self-renewal, and defects in differentiation. Although NZB IRF4(+/-) CLL cells are resistant to apoptosis, high levels of IRF4 inhibit their survival. High levels of IRF4 also reduce the survival of MEC-1 human CLL cells. Our analysis further reveals that high levels of IRF4 suppress Akt activity and can do so without the IRF4 DNA binding domain. Thus, our findings reveal a causal relationship between a low level of IRF4 and the development of CLL and establish IRF4 as a novel regulator in the pathogenesis of CLL.

  6. Servant-Leader Development in an Adult Accelerated Degree Completion Program: A Mixed-Methods Study

    ERIC Educational Resources Information Center

    Anderson, Angela R.

    2009-01-01

    Although many private Christian liberal arts programs exist today that seek to foster servant-leader (SL) development within their students, there is a void of both literature and data that details how servant-leadership development occurs and what contexts may be appropriate or necessary for this development. The purpose of this study was to…

  7. Development and Dosimetric Characterization of a Tissue Substitute (Bolus) For Use in Linear Accelerator Electron Radiotherapy

    NASA Astrophysics Data System (ADS)

    Estrada Trujillo, Jorge; Villaseñor Navarro, Luis Felipe; Mitsoura, Eleni

    2003-09-01

    We propose the design of a new custom made material, to be used as a tissue substitute in external beam electron radiotherapy, based on cotton fabric and beeswax. Due to its inexpensive, easy preparation, constant thickness, flexibility, uniform density and physical properties similar to those of soft tissue, this bolus will insure personalized optimal dose build up and dose distribution in irregular treatment regions. Materials and Methods: We used commercial Campeche beeswax and 100% cotton fabric to prepare the bolus. Beeswax's physical characteristics were determined by thermal and density analysis. Its chemical properties are to be determined by electronic microcopy. We performed quality control tests and calibration of the Varian 2100C linear accelerator. The tissue equivalence of the material is established for a range of electron energies (6, 9, 12, 16, 20 MeV) using a water equivalent solid phantom (PTW; Freiburg, Germany) and a plane parallel ionization chamber (PTW) associated to a PTW electrometer. Results: Beeswax's absolute density was found to be 0.9181g/ml at 21°C, with a melting point of 45°C. For the bolus elaboration, the cotton fabric was soaked in liquid beeswax and thin sheets of approximately 1 mm were obtained. These presented high flexibility, physical stability (color, texture, thickness) and homogeneity. Determination of this dosimetric characteristics and equivalent thickness are still in process. Discussion and conclusions: Our preliminary results suggest that the tissue substitute is easily made, inexpensive to produce, molds well to the treatment area and its positioning is easy and reproducible over the course of the treatment. So we consider that it's a good alternative to the commercial bolus.

  8. Laser-driven x-ray and neutron source development for industrial applications of plasma accelerators

    NASA Astrophysics Data System (ADS)

    Brenner, C. M.; Mirfayzi, S. R.; Rusby, D. R.; Armstrong, C.; Alejo, A.; Wilson, L. A.; Clarke, R.; Ahmed, H.; Butler, N. M. H.; Haddock, D.; Higginson, A.; McClymont, A.; Murphy, C.; Notley, M.; Oliver, P.; Allott, R.; Hernandez-Gomez, C.; Kar, S.; McKenna, P.; Neely, D.

    2016-01-01

    Pulsed beams of energetic x-rays and neutrons from intense laser interactions with solid foils are promising for applications where bright, small emission area sources, capable of multi-modal delivery are ideal. Possible end users of laser-driven multi-modal sources are those requiring advanced non-destructive inspection techniques in industry sectors of high value commerce such as aerospace, nuclear and advanced manufacturing. We report on experimental work that demonstrates multi-modal operation of high power laser-solid interactions for neutron and x-ray beam generation. Measurements and Monte Carlo radiation transport simulations show that neutron yield is increased by a factor ~2 when a 1 mm copper foil is placed behind a 2 mm lithium foil, compared to using a 2 cm block of lithium only. We explore x-ray generation with a 10 picosecond drive pulse in order to tailor the spectral content for radiography with medium density alloy metals. The impact of using  >1 ps pulse duration on laser-accelerated electron beam generation and transport is discussed alongside the optimisation of subsequent bremsstrahlung emission in thin, high atomic number target foils. X-ray spectra are deconvolved from spectrometer measurements and simulation data generated using the GEANT4 Monte Carlo code. We also demonstrate the unique capability of laser-driven x-rays in being able to deliver single pulse high spatial resolution projection imaging of thick metallic objects. Active detector radiographic imaging of industrially relevant sample objects with a 10 ps drive pulse is presented for the first time, demonstrating that features of 200 μm size are resolved when projected at high magnification.

  9. Using a Modified Intervention Mapping Approach to Develop and Refine a Single-Session Motivational Intervention for Methamphetamine-Using Men Who Have Sex With Men

    PubMed Central

    Zule, William A; Coomes, Curtis M; Karg, Rhonda; Harris, Jennie L; Orr, Alex; Wechsberg, Wendee M

    2010-01-01

    There is an ongoing need for the development and adaptation of behavioral interventions to address behaviors related to acquisition and transmission of infectious diseases and for preventing the onset of chronic diseases. This paper describes the application of an established systematic approach to the development of a behavioral intervention to reduce sexual risk behaviors for HIV among men who have sex with men and who use methamphetamine. The approach includes six steps: (1) a needs assessment; (2) preparing matrices of proximal program objectives; (3) selecting theory-based methods and practical strategies; (4) producing program components and materials; (5) planning for program adoption, implementation, and sustainability; and (6) planning for evaluation. The focus of this article is on the intervention development process; therefore the article does not describe steps 5 and 6. Overall the process worked well, although it had to be adapted to fit the sequence of events associated with a funded research project. This project demonstrates that systematic approaches to intervention development can be applied even in research projects where some of the steps occur during the proposal writing process rather than during the actual project. However, intervention developers must remain flexible and be prepared to adapt the process to the situation. This includes being ready to make choices regarding intervention efficacy versus feasibility and being willing to select the best intervention that is likely to be delivered with available resources rather than an ideal intervention that may not be practical. PMID:20657716

  10. Future accelerators (?)

    SciTech Connect

    John Womersley

    2003-08-21

    I describe the future accelerator facilities that are currently foreseen for electroweak scale physics, neutrino physics, and nuclear structure. I will explore the physics justification for these machines, and suggest how the case for future accelerators can be made.

  11. Development of Ta-matrix Nb3Al Strand and Cable for High-Field Accelerator Magnet

    SciTech Connect

    Tsuchiya, K.; Ghosh, A.; Kikuchi, A.; Takeuchi, T.; Banno, N.; Iijima, Y.; Nimori, S.; Takigawa, H.; Terashima, A.; Nakamoto, T.; Kuroda, Y.; Maruyama, M.; Takao, T.; Tanaka, K.; Nakagawa, K.; Barzi, E.; Yamada, R.; Zlobin, A.

    2011-08-03

    Research and development of Nb{sub 3}Al strands and cables for a high field accelerator magnet is ongoing under the framework of the CERN-KEK collaboration. In this program, new Ta-matrix Nb{sub 3}Al strands were developed and their mechanical properties and superconducting properties were studied. The non-Cu J{sub c} values of these strands were 750 {approx} 800 A/mm{sup 2} at 15 T and 4.2 K. Using these strands, test fabrication of 27-strand Rutherford cable was carried out in collaboration with NIMS and Fermilab. The properties of the strands extracted from the cable were examined and it was found that there was no degradation of the superconducting properties of the strands. In this paper, we report the fabrication of the strands and the cable in brief and present some of the results obtained by studying their properties.

  12. Energy and water development appropriations for 1986. Part 4. Hearings before a Subcommittee of the Committee on Appropriations, House of Representatives, Ninety-Ninth Congress, First Session

    SciTech Connect

    Not Available

    1985-01-01

    Part 4 of the hearing record covers the documentation and supporting justification for DOE's 1986 budget. The volume opens with a section on budget highlights, noting a continued support for a mix of energy technologies while emphasizing long-term basic research and near-term technology transfer to industry. The budget continues to emphasize management reforms that will help to reduce the overall budget deficit. The volume also contains justifications for programs in nuclear defense and nuclear wastes, research and development on energy supply, uranium enrichment, geothermal development, power marketing, DOE administration, and the Federal Energy Regulatory Commission.

  13. Accelerator-based BNCT.

    PubMed

    Kreiner, A J; Baldo, M; Bergueiro, J R; Cartelli, D; Castell, W; Thatar Vento, V; Gomez Asoia, J; Mercuri, D; Padulo, J; Suarez Sandin, J C; Erhardt, J; Kesque, J M; Valda, A A; Debray, M E; Somacal, H R; Igarzabal, M; Minsky, D M; Herrera, M S; Capoulat, M E; Gonzalez, S J; del Grosso, M F; Gagetti, L; Suarez Anzorena, M; Gun, M; Carranza, O

    2014-06-01

    The activity in accelerator development for accelerator-based BNCT (AB-BNCT) both worldwide and in Argentina is described. Projects in Russia, UK, Italy, Japan, Israel, and Argentina to develop AB-BNCT around different types of accelerators are briefly presented. In particular, the present status and recent progress of the Argentine project will be reviewed. The topics will cover: intense ion sources, accelerator tubes, transport of intense beams, beam diagnostics, the (9)Be(d,n) reaction as a possible neutron source, Beam Shaping Assemblies (BSA), a treatment room, and treatment planning in realistic cases.

  14. Recording and reenactment of collaborative diagnosis sessions using DICOM.

    PubMed

    von Wangenheim, Aldo; Prüsse, Martin; Maia, Rafael Simon; Abdala, Daniel Duarte; Regert, André Germano; Nobre, Luiz Felipe de Souza; Comunello, Eros

    2009-12-01

    This paper presents a radiological collaborative tool capable of direct manipulation of Digital Imaging and Communications in Medicine (DICOM) images on both sides, and also recording and reenacting of a recorded session. A special collaborative application protocol formerly developed was extended and used as basis for the development of collaborative session recording and playback processes. The protocol is used today for real-time radiological meetings through the Internet. This new standard for collaborative sessions makes possible other uses for the protocol, such as asynchronous collaborative sessions, decision regulation, auditing, and educational applications. Experimental results are given which compare this protocol with other popular collaborative approaches. Comparison of these results shows that the proposed protocol performs much better than other approaches when run under controlled conditions.

  15. Component Development to Accelerate Commercial Implementation of Ultra-Low Emissions Catalytic Combustion

    SciTech Connect

    McCarty, Jon; Berry, Brian; Lundberg, Kare; Anson, Orris

    2003-03-31

    This final report describes a 2000-2003 program for the development of components and processes to enhance the commercialization of ultra-low emissions catalytic combustion in industrial gas turbines. The range of project tasks includes: development of more durable, lower-cost catalysts and catalytic combustor components; development and design of a catalytic pre-burner and a catalytic pilot burner for gas turbines, and on-site fuel conversion processing for utilization of liquid fuel.

  16. Development and Education. International Commission on Education for the Twenty-First Century, Second Session (Dakar, Senegal, September 18-22, 1993).

    ERIC Educational Resources Information Center

    Blondel, Daniele

    This paper reviews the evolution of the different theories concerning education as a factor of development. It is important to see exactly how the struggle against scarcity and the production of material goods can be made more effective by allocating financial and human resources to the production and transmission of knowledge. The growth theory…

  17. Workforce Development Act of 1995. Report together with Additional and Minority Views To Accompany S.143. 104th Congress, 1st Session.

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. Senate Committee on Labor and Human Resources.

    This congressional report addresses the Workforce Development Act of 1995 that would consolidate federal employment training programs and create a new process and structure for funding the programs. Contents include the following: a summary of the bill; background and need for the legislation; history of the legislation and votes in committee;…

  18. Basic Education in Developing Countries. Hearing before the International Task Force of the Select Committee on Hunger. House of Representatives, One Hundredth Congress, First Session.

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. House Select Committee on Hunger.

    The responsibility of the U.S. House of Representatives Task Force on Hunger is to investigate the causes and dimensions of world hunger and to develop legislative recommendations addressing the issues raised. At this hearing, the issue discussed was of basic education as a crucial link in expanding opportunities for poor and hungry people to…

  19. Domestic Violence, 1978; Hearings Before the Subcommittee On Child and Human Development of the Committee on Human Resources, United States Senate, Ninety-Fifty Congress, Second Session.

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. Senate Committee on Human Resources.

    This volume contains the transcripts from the 1978 Congressional hearings from the subcommittee on child and human development. Major topics focus on domestic violence and relevant legislation. Witnesses represented such organizaitons as State Departments of Health, Education and Welfare, the U.S. Senate, Comission on the Status of Women and the…

  20. Development of an ultrasmall C-band linear accelerator guide for a four-dimensional image-guided radiotherapy system with a gimbaled x-ray head.

    PubMed

    Kamino, Yuichiro; Miura, Sadao; Kokubo, Masaki; Yamashita, Ichiro; Hirai, Etsuro; Hiraoka, Masahiro; Ishikawa, Junzo

    2007-05-01

    We are developing a four-dimensional image-guided radiotherapy system with a gimbaled x-ray head. It is capable of pursuing irradiation and delivering irradiation precisely with the help of an agile moving x-ray head on the gimbals. Requirements for the accelerator guide were established, system design was developed, and detailed design was conducted. An accelerator guide was manufactured and basic beam performance and leakage radiation from the accelerator guide were evaluated at a low pulse repetition rate. The accelerator guide including the electron gun is 38 cm long and weighs about 10 kg. The length of the accelerating structure is 24.4 cm. The accelerating structure is a standing wave type and is composed of the axial-coupled injector section and the side-coupled acceleration cavity section. The injector section is composed of one prebuncher cavity, one buncher cavity, one side-coupled half cavity, and two axial coupling cavities. The acceleration cavity section is composed of eight side-coupled nose reentrant cavities and eight coupling cavities. The electron gun is a diode-type gun with a cerium hexaboride (CeB6) direct heating cathode. The accelerator guide can be operated without any magnetic focusing device. Output beam current was 75 mA with a transmission efficiency of 58%, and the average energy was 5.24 MeV. Beam energy was distributed from 4.95 to 5.6 MeV. The beam profile, measured 88 mm from the beam output hole on the axis of the accelerator guide, was 0.7 mm X 0.9 mm full width at half maximum (FWHM) width. The beam loading line was 5.925 (MeV)-Ib (mA) X 0.00808 (MeV/mA), where Ib is output beam current. The maximum radiation leakage of the accelerator guide at 100 cm from the axis of the accelerator guide was calculated as 0.33 cGy/min at the rated x-ray output of 500 cGy/min from the measured value. This leakage requires no radiation shielding for the accelerator guide itself per IEC 60601-2-1.

  1. Accelerated development of cerebral small vessel disease in young stroke patients

    PubMed Central

    Arntz, Renate M.; van den Broek, Steffen M.A.; van Uden, Inge W.M.; Ghafoorian, Mohsen; Platel, Bram; Rutten-Jacobs, Loes C.A.; Maaijwee, Noortje A.M.; Schaapsmeerders, Pauline; Schoonderwaldt, Hennie C.; van Dijk, Ewoud J.

    2016-01-01

    Objective: To study the long-term prevalence of small vessel disease after young stroke and to compare this to healthy controls. Methods: This prospective cohort study comprises 337 patients with an ischemic stroke or TIA, aged 18–50 years, without a history of TIA or stroke. In addition, 90 age- and sex-matched controls were included. At follow-up, lacunes, microbleeds, and white matter hyperintensity (WMH) volume were assessed using MRI. To investigate the relation between risk factors and small vessel disease, logistic and linear regression were used. Results: After mean follow-up of 9.9 (SD 8.1) years, 337 patients were included (227 with an ischemic stroke and 110 with a TIA). Mean age of patients was 49.8 years (SD 10.3) and 45.4% were men; for controls, mean age was 49.4 years (SD 11.9) and 45.6% were men. Compared with controls, patients more often had at least 1 lacune (24.0% vs 4.5%, p < 0.0001). In addition, they had a higher WMH volume (median 1.5 mL [interquartile range (IQR) 0.5–3.7] vs 0.4 mL [IQR 0.0–1.0], p < 0.001). Compared with controls, patients had the same volume WMHs on average 10–20 years earlier. In the patient group, age at stroke (β = 0.03, 95% confidence interval [CI] 0.02–0.04) hypertension (β = 0.22, 95% CI 0.04–0.39), and smoking (β = 0.18, 95% CI 0.01–0.34) at baseline were associated with WMH volume. Conclusions: Patients with a young stroke have a higher burden of small vessel disease than controls adjusted for confounders. Cerebral aging seems accelerated by 10–20 years in these patients, which may suggest an increased vulnerability to vascular risk factors. PMID:27521431

  2. Accelerating the Achievement of the Millennium Development Goals in Ghana: Literacy, the Missing Link

    ERIC Educational Resources Information Center

    Tagoe, Michael Ayitey

    2011-01-01

    The Millennium Development Goals launched in 2001 provide a worldwide agenda to reduce poverty by 2015. Though the eight goals provide synergies for the rapid reduction of poverty, the MDGs have come under criticism for being too narrow and sometimes leaving out critical aspects of human development and well-being. Although the MDGs address some…

  3. The analyst at work: two sessions with Alba.

    PubMed

    Bolognini, Stefano

    2002-08-01

    In this paper, the author presents clinical material that relates to two sessions with a patient called Alba. This analytic work, being of a somewhat unusual character, lends itself to discussion, the author feels, since the technical choices made are undoubtedly very personal and he believes many colleagues might have done things differently. The author endeavours to enrich the account of the sessions with his concomitant thoughts, so as to supply colleagues with the elements, atmosphere and developments of his internal workshop.

  4. Session: Monitoring wind turbine project sites for avian impacts

    SciTech Connect

    Erickson, Wally

    2004-09-01

    This third session at the Wind Energy and Birds/Bats workshop consisted of one presentation followed by a discussion/question and answer period. The focus of the session was on existing wind projects that are monitored for their impacts on birds and bats. The presentation given was titled ''Bird and Bat Fatality Monitoring Methods'' by Wally Erickson, West, Inc. Sections included protocol development and review, methodology, adjusting for scavenging rates, and adjusting for observer detection bias.

  5. SIRA: TREC Session Track 2014

    DTIC Science & Technology

    2014-11-01

    including query topics, initial retrieved webpages , clicked on links, visit times, etc. SIRA has used several methods to improve search results that...sessions include many aspects of a search, including query topics, initial retrieved webpages , clicked on links, visit times, etc. SIRA has used several...which was designed for intelligence analysts researching weapons of mass destruction [5]. In these domains, a small number of specific frames can

  6. Session: Long Valley Exploratory Well

    SciTech Connect

    Tennyson, George P. Jr.; Finger, John T.; Eichelberger, John C.; Hickox, Charles E.

    1992-01-01

    This session at the Geothermal Energy Program Review X: Geothermal Energy and the Utility Market consisted of four presentations: ''Long Valley Exploratory Well - Summary'' by George P. Tennyson, Jr.; ''The Long Valley Well - Phase II Operations'' by John T. Finger; ''Geologic results from the Long Valley Exploratory Well'' by John C. Eichelberger; and ''A Model for Large-Scale Thermal Convection in the Long Valley Geothermal Region'' by Charles E. Hickox.

  7. Search for major genes with progeny test data to accelerate the development of genetically superior loblolly pine

    SciTech Connect

    NCSU

    2003-12-30

    This research project is to develop a novel approach that fully utilized the current breeding materials and genetic test information available from the NCSU-Industry Cooperative Tree Improvement Program to identify major genes that are segregating for growth and disease resistance in loblolly pine. If major genes can be identified in the existing breeding population, they can be utilized directly in the conventional loblolly pine breeding program. With the putative genotypes of parents identified, tree breeders can make effective decisions on management of breeding populations and operational deployment of genetically superior trees. Forest productivity will be significantly enhanced if genetically superior genotypes with major genes for economically important traits could be deployed in an operational plantation program. The overall objective of the project is to develop genetic model and analytical methods for major gene detection with progeny test data and accelerate the development of genetically superior loblolly pine. Specifically, there are three main tasks: (1) Develop genetic models for major gene detection and implement statistical methods and develop computer software for screening progeny test data; (2) Confirm major gene segregation with molecular markers; and (3) Develop strategies for using major genes for tree breeding.

  8. Accelerating the Development and Validation of New Value-Based Diagnostics by Leveraging Biobanks.

    PubMed

    Schneider, Daniel; Riegman, Peter H J; Cronin, Maureen; Negrouk, Anastassia; Moch, Holger; Balling, Rudi; Penault-Llorca, Frederiques; Zatloukal, Kurt; Horgan, Denis

    The challenges faced in developing value-based diagnostics has resulted in few of these tests reaching the clinic, leaving many treatment modalities without matching diagnostics to select patients for particular therapies. Many patients receive therapies from which they are unlikely to benefit, resulting in worse outcomes and wasted health care resources. The paucity of value-based diagnostics is a result of the scientific challenges in developing predictive markers, specifically: (1) complex biology, (2) a limited research infrastructure supporting diagnostic development, and (3) the lack of incentives for diagnostic developers to invest the necessary resources. Better access to biospecimens can address some of these challenges. Methodologies developed to evaluate biomarkers from biospecimens archived from patients enrolled in randomized clinical trials offer the greatest opportunity to develop and validate high-value molecular diagnostics. An alternative opportunity is to access high-quality biospecimens collected from large public and private longitudinal observational cohorts such as the UK Biobank, the US Million Veteran Program, the UK 100,000 Genomes Project, or the French E3N cohort. Value-based diagnostics can be developed to work in a range of samples including blood, serum, plasma, urine, and tumour tissue, and better access to these high-quality biospecimens with clinical data can facilitate biomarker research.

  9. Accelerated Geothermal Resource Development in the Great Basin Through Enhanced Public Awareness and Outreach to Shareholders.

    SciTech Connect

    Taranik, James V.; Oppliger, Gary; Sawatsky, Don

    2002-04-10

    The Great Basin Center for Geothermal Energy conducted work encompassing two main tasks. We (1) produced a web-based, stakeholder geothermal information system for Nevada geothermal data relevant to assessing and developing geothermal resources, and (2) we held informational stakeholder workshops (both as part of GeoPowering the West Initiative). The objective of this grant was to conduct workshops and fund database and web development activities. This grant funds salaries for web and database developers and part of the administrative assistant who helps to coordinate and organize workshops, and maintain selected databases.

  10. Government-industry-uUniversity and rResearch lLaboratories cCoordination for new product development: Session 2. Government research laboratory perspective

    SciTech Connect

    Kuzay, T.M.

    1997-09-01

    This talk is the second in an expanded series of presentations on the Government-Industry-University and Research Laboratories Coordination for new product development, which is a timely and important public policy issue. Such interactions have become particularly timely in light of the present decline in funding for research and development (R&D) in the nation`s budget and in the private sector. These interactions, at least in principle, provide a means to maximize benefits for the greater good of the nation by pooling the diminishing resources. National laboratories, which traditionally interacted closely with the universities in educational training, now are able to also participate closely with industry in joint R&D thanks to a number of public laws legislated since the early 80s. A review of the experiences with such interactions at Argonne National Laboratory, which exemplifies the national laboratories, shows that, despite differences in their traditions and the missions, the national laboratory-industry-university triangle can work together.

  11. Energy and water development appropriations for 1987. Part 5. Hearings before a Subcommittee of the Committee on Appropriations, House of Representatives, Ninety-Ninth Congress, Second Session

    SciTech Connect

    Not Available

    1986-01-01

    Part 5 of the hearing record covers $12.1 billion in appropriations to DOE. Energy Secretary Herrington describes it as adequate to meet DOE's defense and civilian responsibilities and still contribute to the reduction of the national deficit. The budget emphasizes initiatives which would transfer power marketing and the Naval Petroleum Reserves to the private sector, places a moratorium on the Strategic Petroleum Reserve at 500 million barrels, and introduces a new waste disposal program and new cooperative research and development programs in which the federal government serves as a minority partner with industry. Herrington defended the increase in defense activities within the budget and the administration's privatization programs. The volume also includes the budgets for solar and renewable energy sources, magnetic fusion, and the environment; nuclear fission and commercial waste management; general science and Basic Energy Sciences; and uranium supply and enrichment.

  12. Accelerated Capacity Development in Water Resources Education: the experiences of the Ethiopian Institute of Water Resources

    NASA Astrophysics Data System (ADS)

    Alamirew, T.; Mekonnen, G.; Viglione, A.

    2012-04-01

    Ethiopia recently recognises that the water resources development is the major entry point in poverty alleviation and sustainable development. Water in Ethiopia plays a key role in the Water-Energy-Food-nexus. Over 98% of the electricity in the country is generated using hydropower and yet about 2000 MW has been developed. Out of the 3.5 Mha potentially irrigable land, only 0.25 Mha has been developed to date. Access to drinking water supply coverage is among the lowest in the world. One of the limiting factors in harnessing the resource base is the absence of water professionals to face the fast growing demand in education, research, development in the water sector. Recognising this, in collaboration with University of Connecticut of the United States, Addis Ababa University launched the Ethiopian Institute of Water Resources (EIWR) by enrolling 18 PhD and 24 MSc students. The program is unique in that much of the course instructors are coming from US and European Universities, but deliver courses together with Ethiopian collaborators. This is supposed to facilitate knowledge and experience transfer from the US/EU scientist to Ethiopian counterparts. The theses/dissertations are designed to focus on Ethiopia's immediate hydrological problems on selected basins, and will be coordinated by three advisors for each PhD - one from US/EU, one from Ethiopian Universities, and one water professional from the sector. We report here the lessons learned in setting up the EIWR institute and the education program.

  13. Development of a relativistic Particle In Cell code PARTDYN for linear accelerator beam transport

    NASA Astrophysics Data System (ADS)

    Phadte, D.; Patidar, C. B.; Pal, M. K.

    2017-04-01

    A relativistic Particle In Cell (PIC) code PARTDYN is developed for the beam dynamics simulation of z-continuous and bunched beams. The code is implemented in MATLAB using its MEX functionality which allows both ease of development as well higher performance similar to a compiled language like C. The beam dynamics calculations carried out by the code are compared with analytical results and with other well developed codes like PARMELA and BEAMPATH. The effect of finite number of simulation particles on the emittance growth of intense beams has been studied. Corrections to the RF cavity field expressions were incorporated in the code so that the fields could be calculated correctly. The deviations of the beam dynamics results between PARTDYN and BEAMPATH for a cavity driven in zero-mode have been discussed. The beam dynamics studies of the Low Energy Beam Transport (LEBT) using PARTDYN have been presented.

  14. Basic Electropolishing Process Research and Development in Support of Improved Reliable Performance SRF Cavities for the Future Accelerator

    SciTech Connect

    H. Tian, C.E. Reece,M.J. Kelley

    2009-05-01

    Future accelerators require unprecedented cavity performance, which is strongly influenced by interior surface nanosmoothness. Electropolishing is the technique of choice to be developed for high-field superconducting radiofrequency cavities. Electrochemical impedance spectroscopy (EIS) and related techniques point to the electropolishing mechanism of Nb in a sulfuric and hydrofluoric acid electrolyte of controlled by a compact surface salt film under F- diffusion-limited mass transport control. These and other findings are currently guiding a systematic characterization to form the basis for cavity process optimization, such as flowrate, electrolyte composition and temperature. This integrated analysis is expected to provide optimum EP parameter sets for a controlled, reproducible and uniform surface leveling for Nb SRF cavities.

  15. Design and development of a novel nuclear magnetic resonance detection for the gas phase ions by magnetic resonance acceleration technique

    NASA Astrophysics Data System (ADS)

    Fuke, K.; Tona, M.; Fujihara, A.; Sakurai, M.; Ishikawa, H.

    2012-08-01

    Nuclear magnetic resonance (NMR) technique is a well-established powerful tool to study the physical and chemical properties of a wide range of materials. However, presently, NMR applications are essentially limited to materials in the condensed phase. Although magnetic resonance was originally demonstrated in gas phase molecular beam experiments, no application to gas phase molecular ions has yet been demonstrated. Here, we present a novel principle of NMR detection for gas phase ions based on a "magnetic resonance acceleration" technique and describe the design and construction of an apparatus which we are developing. We also present an experimental technique and some results on the formation and manipulation of cold ion packets in a strong magnetic field, which are the key innovations to detect NMR signal using the present method. We expect this novel method to lead new realm for the study of mass-selected gas-phase ions with interesting applications in both fundamental and applied sciences.

  16. Development of a cryogenic load frame for the neutron diffractometer at Takumi in Japan Proton Accelerator Research Complex.

    PubMed

    Jin, Xinzhe; Nakamoto, Tatsushi; Harjo, Stefanus; Hemmi, Tsutomu; Umeno, Takahiro; Ogitsu, Toru; Yamamoto, Akira; Sugano, Michinaka; Aizawa, Kazuya; Abe, Jun; Gong, Wu; Iwahashi, Takaaki

    2013-06-01

    To prepare for projects such as the Large Hadron Collider upgrade, International Thermonuclear Experimental Reactor and Demonstration reactor, it is important to form a clear understanding of stress-strain properties of the materials that make up superconducting magnets. Thus, we have been studying the mechanical properties of superconducting wires using neutron diffraction measurements. To simulate operational conditions such as temperature, stress, and strain, we developed a cryogenic load frame for stress-strain measurements of materials using a neutron diffractometer at Japan Proton Accelerator Research Complex (J-PARC) Takumi beam line. The maximum load that can be applied to a sample using an external driving machine is 50 kN. Using a Gifford-MacMahon cryocooler, samples can be measured down to temperatures below 10 K when loaded. In the present paper, we describe the details of the cryogenic load frame with its test results by using type-304 stainless steel wire.

  17. Recent developments of the ion sources at Tri University Meson Factory/Isotope Separator and ACcelerator Facility.

    PubMed

    Bricault, P G; Ames, F; Dombsky, M; Labrecque, F; Lassen, J; Mjos, A; Minor, G; Tigelhoefer, A

    2012-02-01

    This paper describes the recent progresses concerning the on-line ion source at the Tri University Meson Factory/Isotope Separator and ACcelerator (TRIUMF/ISAC) Radioactive Ion-Beam Facility; description of the new design of the surface-ion-source for improved stability of the beam intensity, description of the transport path to the east target station at ISAC, description of the new brazing techniques that solved recurrent problems with water leaks on the target/ion source assembly in the vacuum system, finally, recent developments concerning the Forced Electron Beam Induced Arc Discharge (FEBIAD) ion source are reported. In particular, a study on the effect of the plasma chamber volume on the ionization efficiency was completed.

  18. Development of an Accelerated Test Design for Predicting the Service Life of the Solar Array at Mead, Nebraska

    NASA Technical Reports Server (NTRS)

    Gaines, G. B.; Thomas, R. E.; Noel, G. T.; Shilliday, T. S.; Wood, V. E.; Carmichael, D. C.

    1979-01-01

    Potential long-term degradation modes for the two types of modules in the Mead array were determined and judgments were made as to those environmental stresses and combinations of stresses which accelerate the degradation of the power output. Hierarchical trees representing the severity of effects of stresses (test conditions) on eleven individual degradation modes were constructed and were pruned of tests judged to be nonessential. Composites of those trees were developed so that there is now one pruned tree covering eight degradation modes, another covering two degradation modes, and a third covering one degradation mode. These three composite trees form the basis for selection of test conditions in the final test plan which is now being prepared.

  19. Research proposal for development of an electron stripper using a thin liquid lithium film for rare isotope accelerator.

    SciTech Connect

    Momozaki, Y.; Nuclear Engineering Division

    2006-03-06

    Hydrodynamic instability phenomena in a thin liquid lithium film, which has been proposed for the first stripper in the driver linac of Rare Isotope Accelerator (RIA), were discussed. Since it was considered that film instability could significantly impair the feasibility of the liquid lithium film stripper concept, potential issues and research tasks in the RIA project due to these instability phenomena were raised. In order to investigate these instability phenomena, a research proposal plan was developed. In the theoretical part of this research proposal, a use of the linear stability theory was suggested. In the experimental part, it was pointed out that the concept of Reynolds number and Weber number scaling may allow conducting a preliminary experiment using inert simulants, hence reducing technical difficulty, complexity, and cost of the experiments. After confirming the thin film formation in the preliminary experiment using simulants, demonstration experiments using liquid lithium were proposed.

  20. The Neuromuscular, Biochemical, and Endocrine Responses to a Single-Session Vs. Double-Session Training Day in Elite Athletes.

    PubMed

    Johnston, Michael J; Cook, Christian J; Drake, David; Costley, Lisa; Johnston, Julie P; Kilduff, Liam P

    2016-11-01

    Johnston, MJ, Cook, CJ, Drake, D, Costley, L, Johnston, JP, and Kilduff, LP. The neuromuscular, biochemical, and endocrine responses to a single-session vs. double-session training day in elite athletes. J Strength Cond Res 30(11): 3098-3106, 2016-The aim of this study was to compare the acute neuromuscular, biochemical, and endocrine responses of a training day consisting of a speed session only with performing a speed-and-weights training session on the same day. Fifteen men who were academy-level rugby players completed 2 protocols in a randomized order. The speed-only protocol involved performing 6 maximal effort repetitions of 50-m running sprints with 5 minutes of recovery between each sprint, whereas the speed-and-weights protocol involved the same sprinting session but was followed 2 hours later by a lower-body weights session consisting of 4 sets of 5 backsquats and Romanian deadlift at 85% one repetition maximum. Testosterone, cortisol, creatine kinase, lactate, and perceived muscle soreness were determined immediately before, immediately after, 2 hours after, and 24 hours after both the protocols. Peak power, relative peak power, jump height, and average rate of force development were determined from a countermovement jump (CMJ) at the same time points. After 24-hours, muscle soreness was significantly higher after the speed-and-weights protocol compared with the speed-only protocol (effect size η = 0.253, F = 4.750, p ≤ 0.05). There was no significant difference between any of the CMJ variables at any of the posttraining time points. Likewise, creatine kinase, testosterone, and cortisol were unaffected by the addition of a weight-training session. These data indicate that the addition of a weight-training session 2 hours after a speed session, whereas increasing the perception of fatigue the next day does not result in a difference in endocrine response or in neuromuscular capability.

  1. Neoadjuvant therapy in muscle-invasive bladder cancer: a model for rational accelerated drug development.

    PubMed

    Balar, Arjun V; Milowsky, Matthew I

    2015-05-01

    Since the advent of cisplatin-based combination therapy in the management of muscle-invasive and advanced bladder cancer, there has been little progress in improving outcomes for patients. Novel therapies beyond cytotoxic chemotherapy are needed. The neoadjuvant paradigm lends to acquiring ample pretreatment and posttreatment tumor tissue as a standard of care, which enables comprehensive biomarker analyses to better understand mechanisms of both response and resistance, which will aid drug development. This article discusses the evolution of neoadjuvant therapy as standard treatment and the role it may serve toward the development of novel therapies.

  2. Accelerated technology development by the use of critical point imaging SEM

    NASA Astrophysics Data System (ADS)

    Sanchez, Dominique; Hinschberger, Benôit; Bouckou, Loemba; Moreau, Olivier; Parisi, Paolo

    2015-03-01

    In order to optimize the time to market of the newest technology nodes and maximize their profitability, advanced semiconductor manufacturers need to adapt their yield enhancement strategies to their current development stage. During very early development, gross Defectivity at some critical process steps often makes it impractical to use broadband plasma or laser scanning micro-defect patterned wafer inspection techniques: such sensitive defect inspections capture a large number of defects, producing wafer defect maps so heavily populated that even wafer level signature are difficult to visualize.

  3. An improved anti-leech mechanism based on session identifier

    NASA Astrophysics Data System (ADS)

    Zhang, Jianbiao; Zhu, Tong; Zhang, Han; Lin, Li

    2011-12-01

    With the rapid development of information technology and extensive requirement of network resource sharing, plenty of resource hotlinking phenomenons appear on the internet. The hotlinking problem not only harms the interests of legal websites but also leads to a great affection to fair internet environment. The anti-leech technique based on session identifier is highly secure, but the transmission of session identifier in plaintext form causes some security flaws. In this paper, a proxy hotlinking technique based on session identifier is introduced firstly to illustrate these security flaws; next, this paper proposes an improved anti-leech mechanism based on session identifier, the mechanism takes the random factor as the core and detects hotlinking request using a map table that contains random factor, user's information and time stamp; at last the paper analyzes the security of mechanism in theory. The result reveals that the improved mechanism has the merits of simple realization, high security and great flexibility.

  4. An improved anti-leech mechanism based on session identifier

    NASA Astrophysics Data System (ADS)

    Zhang, Jianbiao; Zhu, Tong; Zhang, Han; Lin, Li

    2012-01-01

    With the rapid development of information technology and extensive requirement of network resource sharing, plenty of resource hotlinking phenomenons appear on the internet. The hotlinking problem not only harms the interests of legal websites but also leads to a great affection to fair internet environment. The anti-leech technique based on session identifier is highly secure, but the transmission of session identifier in plaintext form causes some security flaws. In this paper, a proxy hotlinking technique based on session identifier is introduced firstly to illustrate these security flaws; next, this paper proposes an improved anti-leech mechanism based on session identifier, the mechanism takes the random factor as the core and detects hotlinking request using a map table that contains random factor, user's information and time stamp; at last the paper analyzes the security of mechanism in theory. The result reveals that the improved mechanism has the merits of simple realization, high security and great flexibility.

  5. Meeting Emergent Needs in Uganda: A Path to Accelerated Development of Community and Work Colleges

    ERIC Educational Resources Information Center

    Cutright, Marc

    2014-01-01

    National development conditions and goals in Uganda, as in many nations, are such that the robust establishment of community colleges could provide many solutions. Yet the creation of such has been inhibited by a number of factors including the historic roots of higher education in former colonial contexts and a lack of Ugandan familiarity with…

  6. Accelerating the development of a therapeutic vaccine for human Chagas disease: rationale and prospects

    PubMed Central

    Zhan, Bin; Heffernan, Michael J; Jones, Kathryn; Valenzuela, Jesus G; Kamhawi, Shaden; Ortega, Jaime; de Leon Rosales, Samuel Ponce; Lee, Bruce Y; Bacon, Kristina M; Fleischer, Bernhard; Slingsby, BT; Cravioto, Miguel Betancourt; Tapia-Conyer, Roberto

    2013-01-01

    Chagas disease is a leading cause of heart disease affecting approximately 10 million people in Latin America and elsewhere worldwide. The two major drugs available for the treatment of Chagas disease have limited efficacy in Trypanosoma cruzi-infected adults with indeterminate (patients who have seroconverted but do not yet show signs or symptoms) and determinate (patients who have both seroconverted and have clinical disease) status; they require prolonged treatment courses and are poorly tolerated and expensive. As an alternative to chemotherapy, an injectable therapeutic Chagas disease vaccine is under development to prevent or delay Chagasic cardiomyopathy in patients with indeterminate or determinate status. The bivalent vaccine will be comprised of two recombinant T. cruzi antigens, Tc24 and TSA-1, formulated on alum together with the Toll-like receptor 4 agonist, E6020. Proof-of-concept for the efficacy of these antigens was obtained in preclinical testing at the Autonomous University of Yucatan. Here the authors discuss the potential for a therapeutic Chagas vaccine as well as the progress made towards such a vaccine, and the authors articulate a roadmap for the development of the vaccine as planned by the nonprofit Sabin Vaccine Institute Product Development Partnership and Texas Children’s Hospital Center for Vaccine Development in collaboration with an international consortium of academic and industrial partners in Mexico, Germany, Japan, and the USA. PMID:23151163

  7. Scenarios for acceleration in fish development and the role of metamorphosis

    NASA Astrophysics Data System (ADS)

    Kooijman, S. A. L. M.; Pecquerie, L.; Augustine, S.; Jusup, M.

    2011-11-01

    We compare various alternative explanations of why embryo development is sometimes slow relative to juvenile and adult development on the basis of the standard Dynamic Energy Budget (DEB) model and make the comparison with avian altricial versus precocial development. We discuss the role of the energy investment ratio, which combines four different aspects of DEBs: allocation, assimilation, mobilisation and costs for structure. We show how this ratio affects the morphology of growth curves: the ratio of the slopes at start and birth during embryonic growth, as well as the von Bertalanffy time as function of ultimate length during post-embryonic growth. We propose an extension of the standard DEB model that combines a Gompertz (i.e. exponential) start with a von Bertalanffy 'tail' with a smooth transition; a combination that has been applied frequently in fisheries research and here given a mechanistic significance. Implications are that a slow embryonic development is combined with a fast post-metamorphic one and that parameters at metamorphosis depend on feeding history prior to metamorphosis. Identical individuals, in terms of parameter values and amounts of reserve and structure, will become permanently different when they experience different (local) environments, even if they experience identical environments after metamorphosis. This might explain part of the parameter variation amongst individuals.

  8. Operational Assessment of Tools for Accelerating Leader Development (ALD): Volume 1, Capstone Report

    DTIC Science & Technology

    2009-06-01

    improvements generally revolved around wording or highlighting changes in the lead-in instructions, the main menu links, the Student Guide , the TSP, or...09, presents the report’s appendices. 15. SUBJECT TERMS Leader Development Web- Based Training Self-Assessment Cognitive Skills ...metacognition, critical thinking skills , and interpersonal skills . The prototype tools include (a) self-assessment instruments plus self- guided learning

  9. NREL Develops Accelerated Sample Activation Process for Hydrogen Storage Materials (Fact Sheet)

    SciTech Connect

    Not Available

    2010-12-01

    This fact sheet describes NREL's accomplishments in developing a new sample activation process that reduces the time to prepare samples for measurement of hydrogen storage from several days to five minutes and provides more uniform samples. Work was performed by NREL's Chemical and Materials Science Center.

  10. The Dielectric Wall Accelerator

    SciTech Connect

    Caporaso, George J.; Chen, Yu-Jiuan; Sampayan, Stephen E.

    2009-01-01

    The Dielectric Wall Accelerator (DWA), a class of induction accelerators, employs a novel insulating beam tube to impress a longitudinal electric field on a bunch of charged particles. The surface flashover characteristics of this tube may permit the attainment of accelerating gradients on the order of 100 MV/m for accelerating pulses on the order of a nanosecond in duration. A virtual traveling wave of excitation along the tube is produced at any desired speed by controlling the timing of pulse generating modules that supply a tangential electric field to the tube wall. Because of the ability to control the speed of this virtual wave, the accelerator is capable of handling any charge to mass ratio particle; hence it can be used for electrons, protons and any ion. The accelerator architectures, key technologies and development challenges will be described.

  11. The SULSA Assay Development Fund: accelerating translation of new biology from academia to pharma.

    PubMed

    McElroy, Stuart P; Jones, Philip S; Barrault, Denise V

    2017-02-01

    With industry increasingly sourcing preclinical drug discovery projects from academia it is important that new academic discoveries are enabled through translation with HTS-ready assays. However, many scientifically interesting, novel molecular targets lack associated high-quality, robust assays suitable for hit finding and development. To bridge this gap, the Scottish Universities Life Sciences Alliance (SULSA) established a fund to develop assays to meet quality criteria such as those of the European Lead Factory. A diverse project portfolio was quickly assembled, and a review of the learnings and successful outcomes showed this fund as a new highly cost-effective model for leveraging significant follow-on resources, training early-career scientists and establishing a culture of translational drug discovery in the academic community.

  12. Digital technologies for cognitive assessment to accelerate drug development in Alzheimer's disease.

    PubMed

    Leurent, C; Ehlers, M D

    2015-11-01

    For many neurological and psychiatric diseases, novel therapeutics have been elusive for decades. By focusing on attention interference in Alzheimer's disease (AD), we provide a future vision on how emerging mobile, computer, and device-based cognitive tools are converting classically noisy, subjective, data-poor clinical endpoints associated with neuropsychiatric disease assessment into a richer, scalable, and objective set of measurements. Incorporation of such endpoints into clinical drug trials holds promise for more quickly and efficiently developing new medicines.

  13. NASA Extreme Environment Mission Operation (NEEMO) 12: Collaborative Accelerated Medical Technology Development

    DTIC Science & Technology

    2007-12-01

    research is indicated to help save the lives and limbs of our injured warfighters. 15. SUBJECT TERMS NEEMO 12, Telesurgery, Robotic Surgery , Military... robotic surgery “competition” at UC’s Center for Surgical Innovation (CSI). These children had a great time with “hands on” learning that was focused...grant. CONCLUSIONS TATRC-led robotic surgery development has continued with this research. During this mission, two surgical robotic systems, the

  14. Single-step affinity purification of enzyme biotherapeutics: a platform methodology for accelerated process development.

    PubMed

    Brower, Kevin P; Ryakala, Venkat K; Bird, Ryan; Godawat, Rahul; Riske, Frank J; Konstantinov, Konstantin; Warikoo, Veena; Gamble, Jean

    2014-01-01

    Downstream sample purification for quality attribute analysis is a significant bottleneck in process development for non-antibody biologics. Multi-step chromatography process train purifications are typically required prior to many critical analytical tests. This prerequisite leads to limited throughput, long lead times to obtain purified product, and significant resource requirements. In this work, immunoaffinity purification technology has been leveraged to achieve single-step affinity purification of two different enzyme biotherapeutics (Fabrazyme® [agalsidase beta] and Enzyme 2) with polyclonal and monoclonal antibodies, respectively, as ligands. Target molecules were rapidly isolated from cell culture harvest in sufficient purity to enable analysis of critical quality attributes (CQAs). Most importantly, this is the first study that demonstrates the application of predictive analytics techniques to predict critical quality attributes of a commercial biologic. The data obtained using the affinity columns were used to generate appropriate models to predict quality attributes that would be obtained after traditional multi-step purification trains. These models empower process development decision-making with drug substance-equivalent product quality information without generation of actual drug substance. Optimization was performed to ensure maximum target recovery and minimal target protein degradation. The methodologies developed for Fabrazyme were successfully reapplied for Enzyme 2, indicating platform opportunities. The impact of the technology is significant, including reductions in time and personnel requirements, rapid product purification, and substantially increased throughput. Applications are discussed, including upstream and downstream process development support to achieve the principles of Quality by Design (QbD) as well as integration with bioprocesses as a process analytical technology (PAT).

  15. Development of Improved Accelerated Corrosion Qualification Test Methodology for Aerospace Materials

    DTIC Science & Technology

    2014-11-01

    irradiation and ozone gas • Cumulative damage model for predicting atmospheric corrosion rates of 1010 steel was developed using inputs from weather...data: – Temperature, – Relative humidity (%RH) – Atmospheric contaminants (chloride, SO2, and ozone ) levels Silver Al Alloy 7075 Al Alloy...2024 Al Alloy 6061 Copper Steel Ozone generator Ozone monitor 10 DISTRIBUTION STATEMENT A. Approved for public release; distribution is unlimited

  16. Enriched environment restricted to gestation accelerates the development of sensory and motor circuits in the rat pup.

    PubMed

    Cárdenas, Lorena; García-García, Fabio; Santiago-Roque, Isela; Martínez, Armando J; Coria-Ávila, Genaro A; Corona-Morales, Aleph A

    2015-04-01

    The effects of stimulating environments on the neural plasticity of the adult brain have been well explored; however, how an enriched environment (EE) affects the mother-fetus interaction is poorly understood. We hypothesized that an enriched environment restricted to pregnancy will succeed in accelerating the development of sensory and motor circuits in the offspring. Pregnant Wistar rats were maintained either under a standard condition - two animals per standard cage- or an enriched environment - eight subjects in larger cages with different physical configurations-. After birth, litters from both groups (n=16 per group) were cross-fostered with mothers that were simultaneously maintained under standard environment during pregnancy. Sensory and motor development were studied in the pups of both groups with a battery of reflex and physical tests. Auditory and gait reflexes appeared two days earlier in the offspring of EE rats as compared to control subjects (p<0.05). In addition, EE pups displayed a better performance in righting reflex, inclined board and geotaxis tests (p<0.05). Differences were found even three weeks after birth. We conclude that EE limited to the phase of pregnancy stimulates the development of pups inutero so that they are born with a higher grade of development.

  17. Humanized mouse as an appropriate model for accelerated global HIV research and vaccine development: current trend.

    PubMed

    Ibeh, Bartholomew Okechukwu; Furuta, Yasuhide; Habu, Josiah Bitrus; Ogbadu, Lucy

    2016-09-23

    Humanized mouse models currently have seen improved development and have received wide applications. Its usefulness is observed in cell and tissue transplant involving basic and applied human disease research. In this article, the development of a new generation of humanized mice was discussed as well as their relevant application in HIV disease. Furthermore, current techniques employed to overcome the initial limitations of mouse model were reviewed. Highly immunodeficient mice which support cell and tissue differentiation and do not reject xenografts are indispensable for generating additional appropriate models useful in disease study, this phenomenom deserves emphases, scientific highlight and a definitive research focus. Since the early 2000s, a series of immunodeficient mice appropriate for generating humanized mice has been successively developed by introducing the IL-2Rγ(null) gene (e.g. NOD/SCID/γc(null) and Rag2(null)γc(null) mice) through various genomic approaches. These mice were generated by genetically introducing human cytokine genes into NOD/SCID/γc(null) and Rag2(null)γc(null) mouse backgrounds. The application of these techniques serves as a quick and appropriate mechanistic model for basic and therapeutic investigations of known and emerging infections.

  18. Accelerating health equity: the key role of universal health coverage in the Sustainable Development Goals.

    PubMed

    Tangcharoensathien, Viroj; Mills, Anne; Palu, Toomas

    2015-04-29

    The Sustainable Development Goals (SDGs), to be committed to by Heads of State at the upcoming 2015 United Nations General Assembly, have set much higher and more ambitious health-related goals and targets than did the Millennium Development Goals (MDGs). The main challenge among MDG off-track countries is the failure to provide and sustain financial access to quality services by communities, especially the poor. Universal health coverage (UHC), one of the SDG health targets indispensable to achieving an improved level and distribution of health, requires a significant increase in government investment in strengthening primary healthcare - the close-to-client service which can result in equitable access. Given the trend of increased fiscal capacity in most developing countries, aiming at long-term progress toward UHC is feasible, if there is political commitment and if focused, effective policies are in place. Trends in high income countries, including an aging population which increases demand for health workers, continue to trigger international migration of health personnel from low and middle income countries. The inspirational SDGs must be matched with redoubled government efforts to strengthen health delivery systems, produce and retain more and relevant health workers, and progressively realize UHC.

  19. High Gradient Accelerator Research

    SciTech Connect

    Temkin, Richard

    2016-07-12

    The goal of the MIT program of research on high gradient acceleration is the development of advanced acceleration concepts that lead to a practical and affordable next generation linear collider at the TeV energy level. Other applications, which are more near-term, include accelerators for materials processing; medicine; defense; mining; security; and inspection. The specific goals of the MIT program are: • Pioneering theoretical research on advanced structures for high gradient acceleration, including photonic structures and metamaterial structures; evaluation of the wakefields in these advanced structures • Experimental research to demonstrate the properties of advanced structures both in low-power microwave cold test and high-power, high-gradient test at megawatt power levels • Experimental research on microwave breakdown at high gradient including studies of breakdown phenomena induced by RF electric fields and RF magnetic fields; development of new diagnostics of the breakdown process • Theoretical research on the physics and engineering features of RF vacuum breakdown • Maintaining and improving the Haimson / MIT 17 GHz accelerator, the highest frequency operational accelerator in the world, a unique facility for accelerator research • Providing the Haimson / MIT 17 GHz accelerator facility as a facility for outside users • Active participation in the US DOE program of High Gradient Collaboration, including joint work with SLAC and with Los Alamos National Laboratory; participation of MIT students in research at the national laboratories • Training the next generation of Ph. D. students in the field of accelerator physics.

  20. Ship-Based Nuclear Energy Systems for Accelerating Developing World Socioeconomic Advance

    NASA Astrophysics Data System (ADS)

    Petroski, Robert; Wood, Lowell

    2014-07-01

    Technological, economic, and policy aspects of supplying energy to newly industrializing and developing countries using ship-deployed nuclear energy systems are described. The approach analyzed comprises nuclear installations of up to gigawatt scale deployed within currently mass-produced large ship hulls which are capable of flexibly supplying energy for electricity, water desalination and district heating-&-cooling with low latencies and minimized shoreside capital expenditures. Nuclear energy is uniquely suited for mobile deployment due to its combination of extraordinary energy density and high power density, which enable enormous supplies of energy to be deployed at extremely low marginal costs. Nuclear installations on ships also confer technological advantages by essentially eliminating risk from earthquakes, tsunamis, and floods; taking advantage of assured access to an effectively unlimited amount of cooling water, and involving minimal onshore preparations and commitments. Instances of floating nuclear power stations that have been proposed in the past, some of which are currently being pursued, have generally been based on conventional LWR technology, moreover without flexibility or completeness of power output options. We consider nuclear technology options for their applicability to the unique opportunities and challenges of a marine environment, with special attention given to low-pressure, high thermal margin systems with continuous and assured afterheat dissipation into the ambient seawater. Such systems appear promising for offering an exceptionally high degree of safety while using a maximally simple set of components. We furthermore consider systems tailored to Developing World contexts, which satisfy societal requirements beyond electrification, e.g., flexible sourcing of potable water and HVAC services, servicing time-varying user requirements, and compatibility with the full spectrum of local renewable energy supplies, specifically including

  1. Accelerated aging of cellulose by laser irradiation. [Development for Shroud of Turin

    SciTech Connect

    Jackson, J.P.; Arthurs, E.; Schwalbe, L.A.; Sega, R.M.; Windish, D.; Long, W.H.; Stappaerts, E.A.

    1988-01-01

    We describe a new technique for studying thermally-induced chemical transformations in cellulose developed for the Shroud of Turin. The apparatus consists of a carbon dioxide laser for heating, an infrared thermometer, and an optical reflectance spectrometer for tracking the progressive discoloration of the sample. To illustrate the technique, we present measurements from a single piece of sample linen along five isotherms in the range 200-290/degree/C. The results are explained in terms of first-order chemical rate theory and a four-step model. From the measurements we derive the activation energies, Arrhenius constants, and reflectivities of the chromophoric states. 4 refs., 2 figs., 1 tab.

  2. Multicore and Accelerator Development for a Leadership-Class Stellar Astrophysics Code

    SciTech Connect

    Messer, Bronson; Harris, James A; Parete-Koon, Suzanne T; Chertkow, Merek A

    2013-01-01

    We describe recent development work on the core-collapse supernova code CHIMERA. CHIMERA has consumed more than 100 million cpu-hours on Oak Ridge Leadership Computing Facility (OLCF) platforms in the past 3 years, ranking it among the most important applications at the OLCF. Most of the work described has been focused on exploiting the multicore nature of the current platform (Jaguar) via, e.g., multithreading using OpenMP. In addition, we have begun a major effort to marshal the computational power of GPUs with CHIMERA. The impending upgrade of Jaguar to Titan a 20+ PF machine with an NVIDIA GPU on many nodes makes this work essential.

  3. Development of Rutherford-type cables for high field accelerator magnets at Fermilab

    SciTech Connect

    Andreev, N.; Barzi, E.; Borissov, E.; Elementi, L.; Kashikhin, V.S.; Lombardo, V.; Rusy, A.; Turrioni, D.; Yamada, R.; Zlobin, A.V.; /Fermilab

    2006-08-01

    Fermilab's cabling facility has been upgraded to a maximum capability of 42 strands. This facility is being used to study the effect of cabling on the performance of the various strands, and for the development and fabrication of cables in support of the ongoing magnet R&D programs. Rutherford cables of various geometries, packing factors, with and without a stainless steel core, were fabricated out of Cu alloys, NbTi, Nb{sub 3}Al, and various Nb{sub 3}Sn strands. The parameters of the upgraded cabling machine and results of cable R&D efforts at Fermilab are reported.

  4. Increased human occupation and agricultural development accelerates the population contraction of an estuarine delphinid

    PubMed Central

    Lin, Wenzhi; Karczmarski, Leszek; Xia, Jia; Zhang, Xiyang; Yu, Xinjian; Wu, Yuping

    2016-01-01

    Over the past few thousand years, human development and population expansion in southern China have led to local extirpation and population contraction of many terrestrial animals. At what extent this early human-induced environmental change has also affected coastal marine species remains poorly known. We investigated the demographic history of the Indo-Pacific humpback dolphin (Sousa chinensis) in the Pearl River Delta (PRD); an obligatory inshore species known for its susceptibility to anthropogenic impacts in one of China’s most developed coastal regions. Although the deltaic evolution of PRD has been influenced by climate since the Holocene, ~74% reduction of the dolphin’s effective population size occurred within the last 2000 years, consistent with ~61% habitat contraction during this period. This considerable and recent population contraction may have been due to land use practices and deforestation in the upper/middle Pearl River region, all leading to increasing sedimentation rate in the estuarine area. As anthropogenic impacts within the drainage of Pearl River affected a vast area, coastal dolphins and large terrestrial mammals in southern China may share a similar demographic history, whilst the demographic and biogeographic history of the PRD humpback dolphins may be symptomatic of similar processes that this species may have undergone elsewhere in the region. PMID:27759106

  5. Gregarine infection accelerates larval development of the cat flea Ctenocephalides felis (Bouché).

    PubMed

    Alarcón, M E; Jara-F, A; Briones, R C; Dubey, A K; Slamovits, C H

    2017-04-01

    A high degree of specialization between host and parasite is a well-known outcome of a long history of coevolution, and it is strikingly illustrated in a coordination of their life cycles. In some cases, the arms race ensued at the establishment of a symbiotic relationship results in the adoption of manipulative strategies by the parasite. We have already learned that Steinina ctenocephali, a gregarine living in the alimentary canal of cat flea, Ctenocephalides felis follows its phenology and metamorphosis. Despite these findings the outcome of their symbiotic partnership (mutualist, parasitic or commensal) remains unclear. To address this important question, we measured life history parameters of the flea in the presence of varying infection intensities of gregarine oocysts in laboratory conditions. We found that neither the emergence nor survival rate of fleas was affected by harbouring the gregarines. More surprisingly, our results show that flea larvae infected with gregarines developed faster and emerged earlier than the control group. This gregarine therefore joins the selected group of protists that can modify physiological host traits and provides not only new model taxa to be explored in an evolutionary scenario, but also potential development of control strategies of cat flea.

  6. Environmental concentration of carbamazepine accelerates fish embryonic development and disturbs larvae behavior.

    PubMed

    Qiang, Liyuan; Cheng, Jinping; Yi, Jun; Rotchell, Jeanette M; Zhu, Xiaotong; Zhou, Junliang

    2016-09-01

    Environmental pollution caused by pharmaceuticals has been recognized as a major threat to the aquatic ecosystems. Carbamazepine, as the widely prescribed antiepileptic drug, has been frequently detected in the aquatic environment and has created concerns about its potential impacts in the aquatic organisms. The effects of carbamazepine on zebrafish embryos were studied by examining their phenotype, behavior and molecular responses. The results showed that carbamazepine disturbed the normal growth and development of exposed zebrafish embryos and larvae. Upon exposure to carbamazepine at 1 μg/L, the hatching rate, body length, swim bladder appearance and yolk sac absorption rate were significantly increased. Embryos in treatment groups were more sensitive to touch and light stimulation. At molecular level, exposure to an environmentally relevant concentration (1 μg/L) of carbamazepine disturbed the expression pattern of neural-related genes of zebrafish embryos and larvae. This study suggests that the exposure of fish embryo to antiepileptic drugs, at environmentally relevant concentrations, affects their early development and impairs their behavior. Such impacts may have future repercussions by affecting fish population structure.

  7. Applying mathematical tools to accelerate vaccine development: modeling Shigella immune dynamics.

    PubMed

    Davis, Courtney L; Wahid, Rezwanul; Toapanta, Franklin R; Simon, Jakub K; Sztein, Marcelo B; Levy, Doron

    2013-01-01

    We establish a mathematical framework for studying immune interactions with Shigella, a bacteria that kills over one million people worldwide every year. The long-term goal of this novel approach is to inform Shigella vaccine design by elucidating which immune components and bacterial targets are crucial for establishing Shigella immunity. Our delay differential equation model focuses on antibody and B cell responses directed against antigens like lipopolysaccharide in Shigella's outer membrane. We find that antibody-based vaccines targeting only surface antigens cannot elicit sufficient immunity for protection. Additional boosting prior to infection would require a four-orders-of-magnitude increase in antibodies to sufficiently prevent epithelial invasion. However, boosting anti-LPS B memory can confer protection, which suggests these cells may correlate with immunity. We see that IgA antibodies are slightly more effective per molecule than IgG, but more total IgA is required due to spatial functionality. An extension of the model reveals that targeting both LPS and epithelial entry proteins is a promising avenue to advance vaccine development. This paper underscores the importance of multifaceted immune targeting in creating an effective Shigella vaccine. It introduces mathematical models to the Shigella vaccine development effort and lays a foundation for joint theoretical/experimental/clinical approaches to Shigella vaccine design.

  8. Accelerated infarct development, cytogenesis and apoptosis following transient cerebral ischemia in aged rats.

    PubMed

    Popa-Wagner, Aurel; Badan, Irina; Walker, Lary; Groppa, Sergiu; Patrana, Nicoleta; Kessler, Christof

    2007-03-01

    Old age is associated with a deficient recovery from stroke, but the cellular mechanisms underlying such phenomena are poorly understood. To address this issue, focal cerebral ischemia was produced by reversible occlusion of the right middle cerebral artery in 3- and 20-month-old male Sprague-Dawley rats. Aged rats showed a delayed and suboptimal functional recovery in the post-stroke period. Using BrdU-labeling, quantitative immunohistochemistry and 3-D reconstruction of confocal images, we found that aged rats are predisposed to rapidly develop an infarct within the first few days after ischemia. The emergence of the necrotic zone is associated with a high rate of cellular degeneration, premature accumulation of proliferating BrdU-positive cells that appear to emanate from capillaries in the infarcted area, and a large number of apoptotic cells. With double labeling techniques, we were able to identify, for the first time, over 60% of BrdU-positive cells either as reactive microglia (45%), oligodendrocyte progenitors (17%), astrocytes (23%), CD8+ lymphocytes (4%), or apoptotic cells (<1%). Paradoxically, despite a robust reactive phenotype of microglia and astrocytes in aged rats, at 1-week post-stroke, the number of proliferating microglia and astrocytes was lower in aged rats than in young rats. Our data indicate that aging is associated with rapid infarct development and a poor prognosis for full recovery from stroke that is correlated with premature cellular proliferation and increased cellular degeneration and apoptosis in the infarcted area.

  9. Practical Session: Simple Linear Regression

    NASA Astrophysics Data System (ADS)

    Clausel, M.; Grégoire, G.

    2014-12-01

    Two exercises are proposed to illustrate the simple linear regression. The first one is based on the famous Galton's data set on heredity. We use the lm R command and get coefficients estimates, standard error of the error, R2, residuals …In the second example, devoted to data related to the vapor tension of mercury, we fit a simple linear regression, predict values, and anticipate on multiple linear regression. This pratical session is an excerpt from practical exercises proposed by A. Dalalyan at EPNC (see Exercises 1 and 2 of http://certis.enpc.fr/~dalalyan/Download/TP_ENPC_4.pdf).

  10. Institutional computing (IC) information session

    SciTech Connect

    Koch, Kenneth R; Lally, Bryan R

    2011-01-19

    The LANL Institutional Computing Program (IC) will host an information session about the current state of unclassified Institutional Computing at Los Alamos, exciting plans for the future, and the current call for proposals for science and engineering projects requiring computing. Program representatives will give short presentations and field questions about the call for proposals and future planned machines, and discuss technical support available to existing and future projects. Los Alamos has started making a serious institutional investment in open computing available to our science projects, and that investment is expected to increase even more.

  11. Working session 3: Tubing integrity

    SciTech Connect

    Cueto-Felgueroso, C.; Strosnider, J.

    1997-02-01

    Twenty-three individuals representing nine countries (Belgium, Canada, the Czech Republic, France, Japan, the Slovak Republic, Spain, the UK, and the US) participated in the session on tube integrity. These individuals represented utilities, vendors, consultants and regulatory authorities. The major subjects discussed by the group included overall objectives of managing steam generator tube degradation, necessary elements of a steam generator degradation management program, the concept of degradation specific management, structural integrity evaluations, leakage evaluations, and specific degradation mechanisms. The group`s discussions on these subjects, including conclusions and recommendations, are summarized in this article.

  12. Effects of Sled Towing on Peak Force, the Rate of Force Development and Sprint Performance During the Acceleration Phase.

    PubMed

    Martínez-Valencia, María Asunción; Romero-Arenas, Salvador; Elvira, José L L; González-Ravé, José María; Navarro-Valdivielso, Fernando; Alcaraz, Pedro E

    2015-06-27

    Resisted sprint training is believed to increase strength specific to sprinting. Therefore, the knowledge of force output in these tasks is essential. The aim of this study was to analyze the effect of sled towing (10%, 15% and 20% of body mass (Bm)) on sprint performance and force production during the acceleration phase. Twenty-three young experienced sprinters (17 men and 6 women; men = 17.9 ± 3.3 years, 1.79 ± 0.06 m and 69.4 ± 6.1 kg; women = 17.2 ± 1.7 years, 1.65 ± 0.04 m and 56.6 ± 2.3 kg) performed four 30 m sprints from a crouch start. Sprint times in 20 and 30 m sprint, peak force (Fpeak), a peak rate of force development (RFDpeak) and time to RFD (TRFD) in first step were recorded. Repeated-measures ANOVA showed significant increases (p ≤ 0.001) in sprint times (20 and 30 m sprint) for each resisted condition as compared to the unloaded condition. The RFDpeak increased significantly when a load increased (3129.4 ± 894.6 N·s-1, p ≤ 0.05 and 3892.4 ± 1377.9 N·s-1, p ≤ 0.01). Otherwise, no significant increases were found in Fpeak and TRFD. The RFD determines the force that can be generated in the early phase of muscle contraction, and it has been considered a factor that influences performance of force-velocity tasks. The use of a load up to 20% Bm might provide a training stimulus in young sprinters to improve the RFDpeak during the sprint start, and thus, early acceleration.

  13. Effects of Sled Towing on Peak Force, the Rate of Force Development and Sprint Performance During the Acceleration Phase

    PubMed Central

    Martínez-Valencia, María Asunción; Romero-Arenas, Salvador; Elvira, José L.L.; González-Ravé, José María; Navarro-Valdivielso, Fernando; Alcaraz, Pedro E.

    2015-01-01

    Resisted sprint training is believed to increase strength specific to sprinting. Therefore, the knowledge of force output in these tasks is essential. The aim of this study was to analyze the effect of sled towing (10%, 15% and 20% of body mass (Bm)) on sprint performance and force production during the acceleration phase. Twenty-three young experienced sprinters (17 men and 6 women; men = 17.9 ± 3.3 years, 1.79 ± 0.06 m and 69.4 ± 6.1 kg; women = 17.2 ± 1.7 years, 1.65 ± 0.04 m and 56.6 ± 2.3 kg) performed four 30 m sprints from a crouch start. Sprint times in 20 and 30 m sprint, peak force (Fpeak), a peak rate of force development (RFDpeak) and time to RFD (TRFD) in first step were recorded. Repeated-measures ANOVA showed significant increases (p ≤ 0.001) in sprint times (20 and 30 m sprint) for each resisted condition as compared to the unloaded condition. The RFDpeak increased significantly when a load increased (3129.4 ± 894.6 N·s−1, p ≤ 0.05 and 3892.4 ± 1377.9 N·s−1, p ≤ 0.01). Otherwise, no significant increases were found in Fpeak and TRFD. The RFD determines the force that can be generated in the early phase of muscle contraction, and it has been considered a factor that influences performance of force-velocity tasks. The use of a load up to 20% Bm might provide a training stimulus in young sprinters to improve the RFDpeak during the sprint start, and thus, early acceleration. PMID:26240657

  14. Accelerating Seed Germination and seedling development of Sorghum (Sorghum bicolor L. Moench) through hydro-priming

    NASA Astrophysics Data System (ADS)

    Dembele, S., Jr.

    2015-12-01

    Mali, a West Africa Sahelian country, is characterized by a strong dependence on rain-fed agriculture and a low adaptive capacity, making it one of the most vulnerable regions to climate change worldwide. Moreover, although with high uncertainties, most climate models used for the region recognize a growing uncertainty in the onset of the rainy season, which demands urgent adaptation measures. Early-season drought limits crops germination, and hence growth, and yield during rainfed depending production as is common now in Mali, West Africa. Crops germination and establishment could be improved by using seed priming, a process that dry seeds take up water to initiate the primary stages of germination, but the amount of water added is not enough for completing germination. The effects of hydro-priming (distilled, tap, rain, river and well water) were evaluated for three priming durations (4, 8 and 12 hour) in 2014 and 2015. Monitored were seed germination and seedling development of nine sorghum genotypes. Preliminary results showed that hydro-priming significantly improved germination rate, germination speed, number of seminal root, rate of survival and seedling vigour index, compared to non-primed seed treatments. However, seedling length, root length, shoot length and seedling dry weight did not differ significantly. Four out of the nine genotypes evaluated were attributed good seed quality and good response to hydro-priming. The priming with different sources of water resulted in higher seed germination (90%) and seedling development with well and river water, compared to the others. Seed germination rate, uniformity and speed were also enhanced by hydro-priming. It is argued that hydro-priming is a simple but effective method for improving seed germination and seedling development of sorghum. In addition hydro-priming is a safe, simple and inexpensive method to enhance germination. The most promising genotypes have consequently been included in consequent pot

  15. PATH Influenza Vaccine Project: accelerating the development of new influenza vaccines for low-resource countries.

    PubMed

    Neuzil, Kathleen M; Tsvetnitsky, Vadim; Nyari, Linda J; Bright, Rick A; Boslego, John W

    2012-08-01

    The 2009 influenza A/H1N1 pandemic demonstrated that a pandemic influenza virus has the potential to spread more rapidly in today's highly interconnected world than in the past. While pandemic morbidity and mortality are likely to be greatest in low-resource countries, manufacturing capacity and access to influenza vaccines predominantly exist in countries with greater resources and infrastructure. Even with recently expanded manufacturing capacity, the number of doses available within a 6-month timeframe would be inadequate to fully immunize the global population if the decision to implement a global vaccination program were made today. Improved, affordable vaccines are needed to limit the consequences of a global influenza outbreak and protect low-resource populations. PATH's Influenza Vaccine Project is supporting a range of activities in collaboration with private- and public-sector partners to advance the development of promising influenza vaccines that can be accessible and affordable for people in low-resource countries.

  16. Initial color development in radiochromic dye films after a short intense pulse of accelerated electrons

    NASA Astrophysics Data System (ADS)

    Uribe, R. M.; Barcelo, M.; McLaughlin, W. L.; Buenfil, A. E.; Rios, J.

    The radiation response of different dye precursors in several host plastics has been investigated after a single short-pulse irradiation with 2.5-MeV electrons. It was observed that in most films the radiation-initiated color development proceeds mainly during the first 300 seconds, after such high dose-rate irradiation (≈ 10 12 Gy/s). Absorption spectra show that the main absorption band increases at the expense of a shorter-wavelength precursor absorption band, showing an isosbestic point approximately midway between the two absorption bands. It was found that a certain combination of dye precursor and host plastic (namely a polyamide containing an aromatic group) constitutes a film which shows a very fast increase in optical density of the main absorption band, making it suitable for immediate dosimetric analysis in very high dose-rate installations.

  17. Large scale chiral chromatography for the separation of an enantiomer to accelerate drug development.

    PubMed

    Hsu, Leo C; Kim, Hyunjung; Yang, Xiqin; Ross, David

    2011-04-01

    There are several approaches to produce enantiomerically pure drug substances, such as recrystallization, catalytic process (ligand and enzyme), indirect chromatographic resolution, and direct chromatographic resolution. However, the use of preparative chromatography with chiral stationary phases seems to be most effective for early phase projects, where the time and resources on the developments need to be minimized to get the drug candidates into the clinical studies. We showed that by following a well-defined process, chiral chromatography can be easily scaled up from an analytical system to a pilot plant system. We also used the results from a multicolumn continuous chromatography (MCC) study to conclude that MCC can be a cost-effective production method for chiral manufacturing.

  18. Development of an Electromagnetic Acceleration Facility for Impact and Fracture Studies at High Strain Rates

    NASA Astrophysics Data System (ADS)

    Pahari, S.; Suryaprasad, I. V. V.; Shiv, N.; Madhavan, S.; Sijoy, C. D.; Chaturvedi, S.

    2011-07-01

    Experimental studies of strain time history and fracture & penetration resulting from the high velocity impact of solid projectiles on solid targets have been initiated. Design, fabrication, testing and commissioning of an electromagnetic impact facility driven by a capacitor bank have been carried out in this regard. The facility presently has an induction coil gun driving a cylindrical hollow/solid projectile on to a target. 3-7 kJ capacitor banks have been used to drive the launchers. The parameters of the coil gun are in consonance with a computer code developed in-house for the validation and optimization of the coil dimension and bank parameters. Systematic studies have been carried out for validation of code and understanding and benchmarking coil performance. Reproducible velocities of the order of 100 m/s have been successfully achieved with projectiles of masses 20 gm. Preliminary impact studies carried out on Alumnium target plates have given the strain time history.

  19. Urbanization Increases Aedes albopictus Larval Habitats and Accelerates Mosquito Development and Survivorship

    PubMed Central

    Li, Yiji; Kamara, Fatmata; Zhou, Guofa; Puthiyakunnon, Santhosh; Li, Chunyuan; Liu, Yanxia; Zhou, Yanhe; Yao, Lijie; Yan, Guiyun; Chen, Xiao-Guang

    2014-01-01

    Introduction Aedes albopictus is a very invasive and aggressive insect vector that causes outbreaks of dengue fever, chikungunya disease, and yellow fever in many countries. Vector ecology and disease epidemiology are strongly affected by environmental changes. Urbanization is a worldwide trend and is one of the most ecologically modifying phenomena. The purpose of this study is to determine how environmental changes due to urbanization affect the ecology of Aedes albopictus. Methods Aquatic habitats and Aedes albopictus larval population surveys were conducted from May to November 2013 in three areas representing rural, suburban, and urban settings in Guangzhou, China. Ae. albopictus adults were collected monthly using BG-Sentinel traps. Ae. albopictus larva and adult life-table experiments were conducted with 20 replicates in each of the three study areas. Results The urban area had the highest and the rural area had the lowest number of aquatic habitats that tested positive for Ae. albopictus larvae. Densities in the larval stages varied among the areas, but the urban area had almost two-fold higher densities in pupae and three-fold higher in adult populations compared with the suburban and rural areas. Larvae developed faster and the adult emergence rate was higher in the urban area than in suburban and rural areas. The survival time of adult mosquitoes was also longer in the urban area than it was in suburban and rural areas. Study regions, surface area, water depth, water clearance, surface type, and canopy coverage were important factors associated with the presence of Ae. albopictus larvae. Conclusions Urbanization substantially increased the density, larval development rate, and adult survival time of Ae. albopictus, which in turn potentially increased the vector capacity, and therefore, disease transmissibility. Mosquito ecology and its correlation with dengue virus transmission should be compared in different environmental settings. PMID:25393814

  20. Communicating Earth Science Applications through Virtual Poster Sessions

    NASA Astrophysics Data System (ADS)

    Favors, J. E.; Childs-Gleason, L. M.; Ross, K. W.; Ruiz, M. L.; Rogers, L.

    2013-12-01

    The DEVELOP National Program addresses environmental and public policy issues through interdisciplinary research projects that apply the lens of NASA Earth observations to community concerns around the globe. Part of NASA's Applied Sciences' Capacity Building Program, DEVELOP bridges the gap between NASA Earth Science and society, building capacity in both participants and partner organizations to better prepare them to handle the challenges that face our society and future generations. Teams of DEVELOP participants partner with decision makers to conduct rapid feasibility projects that highlight fresh applications of NASA's suite of Earth observing sensors, cultivate advanced skills, and increase understanding of NASA Earth Science data and technology. Part of this process involves the creation of short introductory videos that demonstrate the environmental concerns, project methodologies and results, and an overview of how this work will impact decision makers. These videos are presented to the public three times a year in 'virtual poster sessions' (VPS) that provide an interactive way for individuals from around the globe to access the research, understand the capabilities and applications of NASA's Earth science datasets, and interact with the participants through blogging and dialogue sessions. Virtual poster sessions have allowed DEVELOP to introduce NASA's Earth science assets to thousands of viewers around the world. For instance, one fall VPS had over 5,000 visitors from 89 different countries during the two week session. This presentation will discuss lessons learned and statistics related to the series of nine virtual poster sessions that DEVELOP has conducted 2011-2013.

  1. Recommendations for the development of rare disease drugs using the accelerated approval pathway and for qualifying biomarkers as primary endpoints.

    PubMed

    Kakkis, Emil D; O'Donovan, Mary; Cox, Gerald; Hayes, Mark; Goodsaid, Federico; Tandon, P K; Furlong, Pat; Boynton, Susan; Bozic, Mladen; Orfali, May; Thornton, Mark

    2015-02-10

    For rare serious and life-threatening disorders, there is a tremendous challenge of transforming scientific discoveries into new drug treatments. This challenge has been recognized by all stakeholders who endorse the need for flexibility in the regulatory review process for novel therapeutics to treat rare diseases. In the United States, the best expression of this flexibility was the creation of the Accelerated Approval (AA) pathway. The AA pathway is critically important for the development of treatments for diseases with high unmet medical need and has been used extensively for drugs used to treat cancer and infectious diseases like HIV.In 2012, the AA provisions were amended to enhance the application of the AA pathway to expedite the development of drugs for rare disorders under the Food and Drug Administration Safety and Innovation Act (FDASIA). FDASIA, among many provisions, requires the development of a more relevant FDA guidance on the types of evidence that may be acceptable in support of using a novel surrogate endpoint. The application of AA to rare diseases requires more predictability to drive greater access to appropriate use of AA for more rare disease treatments that might not be developed otherwise.This white paper proposes a scientific framework for assessing biomarker endpoints to enhance the development of novel therapeutics for rare and devastating diseases currently without adequate treatment and is based on the opinions of experts in drug development and rare disease patient groups. Specific recommendations include: 1) Establishing regulatory rationale for increased AA access in rare disease programs; 2) Implementing a Biomarker Qualification Request Process to provide the opportunity for an early determination of biomarker acceptance; and 3) A proposed scientific framework for qualifying biomarkers as primary endpoints. The paper's final section highlights case studies of successful examples that have incorporated biomarker endpoints into

  2. Powered by DFT: Screening methods that accelerate materials development for hydrogen in metals applications.

    PubMed

    Nicholson, Kelly M; Chandrasekhar, Nita; Sholl, David S

    2014-11-18

    CONSPECTUS: Not only is hydrogen critical for current chemical and refining processes, it is also projected to be an important energy carrier for future green energy systems such as fuel cell vehicles. Scientists have examined light metal hydrides for this purpose, which need to have both good thermodynamic properties and fast charging/discharging kinetics. The properties of hydrogen in metals are also important in the development of membranes for hydrogen purification. In this Account, we highlight our recent work aimed at the large scale screening of metal-based systems with either favorable hydrogen capacities and thermodynamics for hydrogen storage in metal hydrides for use in onboard fuel cell vehicles or promising hydrogen permeabilities relative to pure Pd for hydrogen separation from high temperature mixed gas streams using dense metal membranes. Previously, chemists have found that the metal hydrides need to hit a stability sweet spot: if the compound is too stable, it will not release enough hydrogen under low temperatures; if the compound is too unstable, the reaction may not be reversible under practical conditions. Fortunately, we can use DFT-based methods to assess this stability via prediction of thermodynamic properties, equilibrium reaction pathways, and phase diagrams for candidate metal hydride systems with reasonable accuracy using only proposed crystal structures and compositions as inputs. We have efficiently screened millions of mixtures of pure metals, metal hydrides, and alloys to identify promising reaction schemes via the grand canonical linear programming method. Pure Pd and Pd-based membranes have ideal hydrogen selectivities over other gases but suffer shortcomings such as sensitivity to sulfur poisoning and hydrogen embrittlement. Using a combination of detailed DFT, Monte Carlo techniques, and simplified models, we are able to accurately predict hydrogen permeabilities of metal membranes and screen large libraries of candidate alloys

  3. Diagnostics for induction accelerators

    SciTech Connect

    Fessenden, T.J.

    1996-04-01

    The induction accelerator was conceived by N. C. Christofilos and first realized as the Astron accelerator that operated at LLNL from the early 1960`s to the end of 1975. This accelerator generated electron beams at energies near 6 MeV with typical currents of 600 Amperes in 400 ns pulses. The Advanced Test Accelerator (ATA) built at Livermore`s Site 300 produced 10,000 Ampere beams with pulse widths of 70 ns at energies approaching 50 MeV. Several other electron and ion induction accelerators have been fabricated at LLNL and LBNL. This paper reviews the principal diagnostics developed through efforts by scientists at both laboratories for measuring the current, position, energy, and emittance of beams generated by these high current, short pulse accelerators. Many of these diagnostics are closely related to those developed for other accelerators. However, the very fast and intense current pulses often require special diagnostic techniques and considerations. The physics and design of the more unique diagnostics developed for electron induction accelerators are presented and discussed in detail.

  4. Targeted disruption of fibrinogen like protein-1 accelerates hepatocellular carcinoma development

    PubMed Central

    Nayeb-Hashemi, Hamed; Desai, Anal; Demchev, Valeriy; Bronson, Roderick T.; Hornick, Jason L.; Cohen, David E.; Ukomadu, Chinweike

    2015-01-01

    Fibrinogen like protein-1 (Fgl1) is a predominantly liver expressed protein that has been implicated as both a hepatoprotectant and a hepatocyte mitogen. Fgl1 expression is decreased in hepatocellular carcinoma (HCC) and its loss correlates with a poorly differentiated phenotype. To better elucidate the role of Fgl1 in hepatocarcinogenesis, we treated mice wild type or null for Fgl1 with diethyl nitrosamine and monitored for incidence of hepatocellular cancer. We find that mice lacking Fgl1 develop HCC at more than twice the rate of wild type mice. We show that hepatocellular cancers from Fgl1 null mice are molecularly distinct from those of the wild type mice. In tumors from Fgl1 null mice there is enhanced activation of Akt and downstream targets of the mammalian target of rapamycin (mTOR). In addition, there is paradoxical up regulation of putative hepatocellular cancer tumor suppressors; tripartite motif-containing protein 35 (Trim35) and tumor necrosis factor super family 10b (Tnfrsf10b). Taken together, these findings suggest that Fgl1 acts as a tumor suppressor in hepatocellular cancer through an Akt dependent mechanism and supports its role as a potential therapeutic target in HCC. PMID:26225745

  5. Gradient and High-Throughput Methods for the Accelerated Development of Nanomaterials and Nanometrology

    NASA Astrophysics Data System (ADS)

    Fasolka, Michael J.

    2005-03-01

    Increasingly, new materials are highly tailored towards specific applications, are formulated from many components, and exhibit behavior governed by a multitude of physical, chemical and processing factors. Accordingly, the discovery and optimization of materials are met by considerable challenges inherent to the understanding of large, complex parameter spaces. In this respect, combinatorial and high-throughput (C&HT) approaches are advantageous, since they present the ability to rapidly assess materials properties over large parameter ranges. The NIST Combinatorial Methods Center (NCMC, see www.nist.gov/combi) specializes in the development of quantitative C&HT measurement methods for materials research. In large part, the NCMC concentrates on continuous gradient (CG) combinatorial methods, which involve the fabrication and HT measurement of systems that gradually vary parameters over a single specimen, and which offer an alternative to the (often costly) robotics-driven C&HT paradigm used by the pharmaceutical industry. CG techniques are particularly suited for materials science since they naturally produce thorough maps (e.g. continuous phase diagrams) that relate materials properties to chemical, compositional, physical and processing parameters. This presentation focuses on NCMC research applied to the advancement of polymer-based nanotechnology. Topics to be discussed include CG techniques for the design and optimization of self-assembled systems, ultra-thin films, and intelligent surfaces; and HT methods for measuring thin film morphology and mechanical properties. In addition, the application of CG methods to the advancement of nanometrology, specifically scanned probe microscopy, will be discussed.

  6. Policies for accelerating access to clean energy, improving health, advancing development, and mitigating climate change.

    PubMed

    Haines, Andy; Smith, Kirk R; Anderson, Dennis; Epstein, Paul R; McMichael, Anthony J; Roberts, Ian; Wilkinson, Paul; Woodcock, James; Woods, Jeremy

    2007-10-06

    The absence of reliable access to clean energy and the services it provides imposes a large disease burden on low-income populations and impedes prospects for development. Furthermore, current patterns of fossil-fuel use cause substantial ill-health from air pollution and occupational hazards. Impending climate change, mainly driven by energy use, now also threatens health. Policies to promote access to non-polluting and sustainable sources of energy have great potential both to improve public health and to mitigate (prevent) climate disruption. There are several technological options, policy levers, and economic instruments for sectors such as power generation, transport, agriculture, and the built environment. However, barriers to change include vested interests, political inertia, inability to take meaningful action, profound global inequalities, weak technology-transfer mechanisms, and knowledge gaps that must be addressed to transform global markets. The need for policies that prevent dangerous anthropogenic interference with the climate while addressing the energy needs of disadvantaged people is a central challenge of the current era. A comprehensive programme for clean energy should optimise mitigation and, simultaneously, adaption to climate change while maximising co-benefits for health--eg, through improved air, water, and food quality. Intersectoral research and concerted action, both nationally and internationally, will be required.

  7. Session Two Outcome of the Formula First Session Task in Problem- and Solution-Focused Approaches.

    ERIC Educational Resources Information Center

    Jordan, Karin; Quinn, William H.

    1994-01-01

    Evaluated treatment effects in single session process using problem-focused approach and solution-focused approach. Findings indicated significant difference between two approaches when dealing with client's perceived problem improvement, outcome expectancy, session depth, session smoothness, and session positivity. Found no significant…

  8. Virtual Neurorobotics (VNR) to Accelerate Development of Plausible Neuromorphic Brain Architectures.

    PubMed

    Goodman, Philip H; Buntha, Sermsak; Zou, Quan; Dascalu, Sergiu-Mihai

    2007-01-01

    Traditional research in artificial intelligence and machine learning has viewed the brain as a specially adapted information-processing system. More recently the field of social robotics has been advanced to capture the important dynamics of human cognition and interaction. An overarching societal goal of this research is to incorporate the resultant knowledge about intelligence into technology for prosthetic, assistive, security, and decision support applications. However, despite many decades of investment in learning and classification systems, this paradigm has yet to yield truly "intelligent" systems. For this reason, many investigators are now attempting to incorporate more realistic neuromorphic properties into machine learning systems, encouraged by over two decades of neuroscience research that has provided parameters that characterize the brain's interdependent genomic, proteomic, metabolomic, anatomic, and electrophysiological networks. Given the complexity of neural systems, developing tenable models to capture the essence of natural intelligence for real-time application requires that we discriminate features underlying information processing and intrinsic motivation from those reflecting biological constraints (such as maintaining structural integrity and transporting metabolic products). We propose herein a conceptual framework and an iterative method of virtual neurorobotics (VNR) intended to rapidly forward-engineer and test progressively more complex putative neuromorphic brain prototypes for their ability to support intrinsically intelligent, intentional interaction with humans. The VNR system is based on the viewpoint that a truly intelligent system must be driven by emotion rather than programmed tasking, incorporating intrinsic motivation and intentionality. We report pilot results of a closed-loop, real-time interactive VNR system with a spiking neural brain, and provide a video demonstration as online supplemental material.

  9. Developmental acceleration of bradykinin-dependent relaxation by prenatal chronic hypoxia impedes normal development after birth

    PubMed Central

    Blum-Johnston, Carla; Thorpe, Richard B.; Wee, Chelsea; Romero, Monica; Brunelle, Alexander; Blood, Quintin; Blood, Arlin B.; Francis, Michael; Taylor, Mark S.; Longo, Lawrence D.; Pearce, William J.; Wilson, Sean M.

    2015-01-01

    Bradykinin-induced activation of the pulmonary endothelium triggers nitric oxide production and other signals that cause vasorelaxation, including stimulation of large-conductance Ca2+-activated K+ (BKCa) channels in myocytes that hyperpolarize the plasma membrane and decrease intracellular Ca2+. Intrauterine chronic hypoxia (CH) may reduce vasorelaxation in the fetal-to-newborn transition and contribute to pulmonary hypertension of the newborn. Thus we examined the effects of maturation and CH on the role of BKCa channels during bradykinin-induced vasorelaxation by examining endothelial Ca2+ signals, wire myography, and Western immunoblots on pulmonary arteries isolated from near-term fetal (∼140 days gestation) and newborn, 10- to 20-day-old, sheep that lived in normoxia at 700 m or in CH at high altitude (3,801 m) for >100 days. CH enhanced bradykinin-induced relaxation of fetal vessels but decreased relaxation in newborns. Endothelial Ca2+ responses decreased with maturation but increased with CH. Bradykinin-dependent relaxation was sensitive to 100 μM nitro-l-arginine methyl ester or 10 μM 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one, supporting roles for endothelial nitric oxide synthase and soluble guanylate cyclase activation. Indomethacin blocked relaxation in CH vessels, suggesting upregulation of PLA2 pathways. BKCa channel inhibition with 1 mM tetraethylammonium reduced bradykinin-induced vasorelaxation in the normoxic newborn and fetal CH vessels. Maturation reduced whole cell BKCa channel α1-subunit expression but increased β1-subunit expression. These results suggest that CH amplifies the contribution of BKCa channels to bradykinin-induced vasorelaxation in fetal sheep but stunts further development of this vasodilatory pathway in newborns. This involves complex changes in multiple components of the bradykinin-signaling axes. PMID:26637638

  10. Developing Subdomain Allocation Algorithms Based on Spatial and Communicational Constraints to Accelerate Dust Storm Simulation

    PubMed Central

    Gui, Zhipeng; Yu, Manzhu; Yang, Chaowei; Jiang, Yunfeng; Chen, Songqing; Xia, Jizhe; Huang, Qunying; Liu, Kai; Li, Zhenlong; Hassan, Mohammed Anowarul; Jin, Baoxuan

    2016-01-01

    Dust storm has serious disastrous impacts on environment, human health, and assets. The developments and applications of dust storm models have contributed significantly to better understand and predict the distribution, intensity and structure of dust storms. However, dust storm simulation is a data and computing intensive process. To improve the computing performance, high performance computing has been widely adopted by dividing the entire study area into multiple subdomains and allocating each subdomain on different computing nodes in a parallel fashion. Inappropriate allocation may introduce imbalanced task loads and unnecessary communications among computing nodes. Therefore, allocation is a key factor that may impact the efficiency of parallel process. An allocation algorithm is expected to consider the computing cost and communication cost for each computing node to minimize total execution time and reduce overall communication cost for the entire simulation. This research introduces three algorithms to optimize the allocation by considering the spatial and communicational constraints: 1) an Integer Linear Programming (ILP) based algorithm from combinational optimization perspective; 2) a K-Means and Kernighan-Lin combined heuristic algorithm (K&K) integrating geometric and coordinate-free methods by merging local and global partitioning; 3) an automatic seeded region growing based geometric and local partitioning algorithm (ASRG). The performance and effectiveness of the three algorithms are compared based on different factors. Further, we adopt the K&K algorithm as the demonstrated algorithm for the experiment of dust model simulation with the non-hydrostatic mesoscale model (NMM-dust) and compared the performance with the MPI default sequential allocation. The results demonstrate that K&K method significantly improves the simulation performance with better subdomain allocation. This method can also be adopted for other relevant atmospheric and numerical

  11. Targeted disruption of fibrinogen like protein-1 accelerates hepatocellular carcinoma development

    SciTech Connect

    Nayeb-Hashemi, Hamed; Desai, Anal; Demchev, Valeriy; Bronson, Roderick T.; Hornick, Jason L.; Cohen, David E.; Ukomadu, Chinweike

    2015-09-18

    Fibrinogen like protein-1 (Fgl1) is a predominantly liver expressed protein that has been implicated as both a hepatoprotectant and a hepatocyte mitogen. Fgl1 expression is decreased in hepatocellular carcinoma (HCC) and its loss correlates with a poorly differentiated phenotype. To better elucidate the role of Fgl1 in hepatocarcinogenesis, we treated mice wild type or null for Fgl1 with diethyl nitrosamine and monitored for incidence of hepatocellular cancer. We find that mice lacking Fgl1 develop HCC at more than twice the rate of wild type mice. We show that hepatocellular cancers from Fgl1 null mice are molecularly distinct from those of the wild type mice. In tumors from Fgl1 null mice there is enhanced activation of Akt and downstream targets of the mammalian target of rapamycin (mTOR). In addition, there is paradoxical up regulation of putative hepatocellular cancer tumor suppressors; tripartite motif-containing protein 35 (Trim35) and tumor necrosis factor super family 10b (Tnfrsf10b). Taken together, these findings suggest that Fgl1 acts as a tumor suppressor in hepatocellular cancer through an Akt dependent mechanism and supports its role as a potential therapeutic target in HCC. - Highlights: • Fgl1 knockout mice (Fgl1KO) are more prone to carcinogen-induced liver cancer compared to wild type (WT) mates. • Tumors from the Fgl1KO are molecularly distinct with enhanced Akt and mTOR activity in comparison with Fgl1WT tumors. • Tumors from the Fgl1KO have enhanced expression of Trim35 and Tnfrsf10b, putative HCC tumor suppressors.

  12. Virtual Neurorobotics (VNR) to Accelerate Development of Plausible Neuromorphic Brain Architectures

    PubMed Central

    Goodman, Philip H.; Buntha, Sermsak; Zou, Quan; Dascalu, Sergiu-Mihai

    2007-01-01

    Traditional research in artificial intelligence and machine learning has viewed the brain as a specially adapted information-processing system. More recently the field of social robotics has been advanced to capture the important dynamics of human cognition and interaction. An overarching societal goal of this research is to incorporate the resultant knowledge about intelligence into technology for prosthetic, assistive, security, and decision support applications. However, despite many decades of investment in learning and classification systems, this paradigm has yet to yield truly “intelligent” systems. For this reason, many investigators are now attempting to incorporate more realistic neuromorphic properties into machine learning systems, encouraged by over two decades of neuroscience research that has provided parameters that characterize the brain's interdependent genomic, proteomic, metabolomic, anatomic, and electrophysiological networks. Given the complexity of neural systems, developing tenable models to capture the essence of natural intelligence for real-time application requires that we discriminate features underlying information processing and intrinsic motivation from those reflecting biological constraints (such as maintaining structural integrity and transporting metabolic products). We propose herein a conceptual framework and an iterative method of virtual neurorobotics (VNR) intended to rapidly forward-engineer and test progressively more complex putative neuromorphic brain prototypes for their ability to support intrinsically intelligent, intentional interaction with humans. The VNR system is based on the viewpoint that a truly intelligent system must be driven by emotion rather than programmed tasking, incorporating intrinsic motivation and intentionality. We report pilot results of a closed-loop, real-time interactive VNR system with a spiking neural brain, and provide a video demonstration as online supplemental material. PMID:18958272

  13. Developing Subdomain Allocation Algorithms Based on Spatial and Communicational Constraints to Accelerate Dust Storm Simulation.

    PubMed

    Gui, Zhipeng; Yu, Manzhu; Yang, Chaowei; Jiang, Yunfeng; Chen, Songqing; Xia, Jizhe; Huang, Qunying; Liu, Kai; Li, Zhenlong; Hassan, Mohammed Anowarul; Jin, Baoxuan

    2016-01-01

    Dust storm has serious disastrous impacts on environment, human health, and assets. The developments and applications of dust storm models have contributed significantly to better understand and predict the distribution, intensity and structure of dust storms. However, dust storm simulation is a data and computing intensive process. To improve the computing performance, high performance computing has been widely adopted by dividing the entire study area into multiple subdomains and allocating each subdomain on different computing nodes in a parallel fashion. Inappropriate allocation may introduce imbalanced task loads and unnecessary communications among computing nodes. Therefore, allocation is a key factor that may impact the efficiency of parallel process. An allocation algorithm is expected to consider the computing cost and communication cost for each computing node to minimize total execution time and reduce overall communication cost for the entire simulation. This research introduces three algorithms to optimize the allocation by considering the spatial and communicational constraints: 1) an Integer Linear Programming (ILP) based algorithm from combinational optimization perspective; 2) a K-Means and Kernighan-Lin combined heuristic algorithm (K&K) integrating geometric and coordinate-free methods by merging local and global partitioning; 3) an automatic seeded region growing based geometric and local partitioning algorithm (ASRG). The performance and effectiveness of the three algorithms are compared based on different factors. Further, we adopt the K&K algorithm as the demonstrated algorithm for the experiment of dust model simulation with the non-hydrostatic mesoscale model (NMM-dust) and compared the performance with the MPI default sequential allocation. The results demonstrate that K&K method significantly improves the simulation performance with better subdomain allocation. This method can also be adopted for other relevant atmospheric and numerical

  14. Accelerated behavioural development changes fine-scale search behaviour and spatial memory in honey bees (Apis mellifera L.).

    PubMed

    Ushitani, Tomokazu; Perry, Clint J; Cheng, Ken; Barron, Andrew B

    2016-02-01

    Normally, worker honey bees (Apis mellifera) begin foraging when more than 2 weeks old as adults, but if individual bees or the colony is stressed, bees often begin foraging precociously. Here, we examined whether bees that accelerated their behavioural development to begin foraging precociously differed from normal-aged foragers in cognitive performance. We used a social manipulation to generate precocious foragers from small experimental colonies and tested their performance in a free-flight visual reversal learning task, and a test of spatial memory. To assess spatial memory, bees were trained to learn the location of a small sucrose feeder within an array of three landmarks. In tests, the feeder and one landmark were removed and the search behaviour of the bees was recorded. Performance of precocious and normal-aged foragers did not differ in a visual reversal learning task, but the two groups showed a clear difference in spatial memory. Flight behaviour suggested normal-aged foragers were better able to infer the position of the removed landmark and feeder relative to the remaining landmarks than precocious foragers. Previous studies have documented the cognitive decline of old foragers, but this is the first suggestion of a cognitive deficit in young foragers. These data imply that worker honey bees continue their cognitive development during the adult stage. These findings may also help to explain why precocious foragers perform quite poorly as foragers and have a higher than normal loss rate.

  15. Microdosing: a valuable tool for accelerating drug development and the role of bioanalytical methods in meeting the challenge.

    PubMed

    Ings, Robert M J

    2009-10-01

    The concept of specifically determining the clinical pharmacokinetics of a compound using a very low nonpharmacologically active dose (microdose) with an abridged safety and chemistry, manufacturing and control package is relatively new. It is not without its controversy and it is still a subject of discussion. Here, the rationale and application of this approach are examined, together with the regulatory and bioanalytical framework. There are two bioanalytical methods commonly used for human microdosing studies: LC-MS/MS and accelerator MS (AMS). Each method has advantages and disadvantages with the choice of instrumentation being closely tied to the primary objective(s) of the study. If a rapid decision is required on the appropriateness of a pharmacokinetic profile or if a choice is needed from a series of compounds, especially before radiolabeled material is available, LC-MS/MS may be preferable. However, if extreme sensitivity is required, data are required on all drug-related material and metabolites, or a simultaneous intravenous microdose is used to determine absolute bioavailability (sometimes referred to as microtracing), AMS becomes the analytical method of choice. Examples are provided of microdosing studies utilizing both of these bioanalytical techniques. It is emphasized that microdosing is only one tool in the drug developer's tool box and it should be used in the context of all available data. However, when used appropriately, microdosing is a valuable tool, bridging between lead optimization and early clinical development.

  16. The Charged Pion Polarizability Experiment at the Thomas Jefferson National Accelerator Facility: Developing Muon Chambers and Experiment Simulation

    NASA Astrophysics Data System (ADS)

    Johnston, Bobby; Miskimen, Rory; Downing, Matthew; Haughwout, Christian; Schick, Andrew; Jefferson Lab Hall D Collaboration

    2016-09-01

    The Thomas Jefferson National Accelerator Facility has proposed to make a precision measurement of the charged pion polarizability through measurements of γγ ->π+π- cross sections using the new GlueX detector. This experiment will have a large muon background which must be filtered out of the pion signal. For this issue we are developing an array of Multi-Wire Proportional Chambers (MWPCs) that will allow the pions to be identified from the muons, permitting a precise measurement of the polarizability. Small (1:8 scale) and medium (1:5 scale) sized prototypes have been constructed and tested, and a full scale prototype is currently being assembled. MWPC electronics were developed and tested to amplify the signal from the detection chamber, and were designed to interface with Jefferson Lab's existing data acquisition system. In order to construct the detectors, a class 10,000 clean room was assembled specifically for this purpose. Lastly, Geant4 software is being used to run Monte Carlo simulations of the experiment. This allows us to determine the optimal orientation and number of MWPCs needed for proper filtering which will indicate how many more MWPCs must be built before the experiment can be run. Department of Energy.

  17. AT2 DS II - Accelerator System Design (Part II) - CCC Video Conference

    SciTech Connect

    2010-12-17

    Discussion Session - Accelerator System Design (Part II) Tutors: C. Darve, J. Weisend II, Ph. Lebrun, A. Dabrowski, U. Raich Video Conference with the CERN Control Center. Experts in the field of Accelerator science will be available to answer the students questions. This session will link the CCC and SA (using Codec VC).

  18. AT2 DS II - Accelerator System Design (Part II) - CCC Video Conference

    ScienceCinema

    None

    2016-07-12

    Discussion Session - Accelerator System Design (Part II) Tutors: C. Darve, J. Weisend II, Ph. Lebrun, A. Dabrowski, U. Raich Video Conference with the CERN Control Center. Experts in the field of Accelerator science will be available to answer the students questions. This session will link the CCC and SA (using Codec VC).

  19. Enhancement of chronic acceleration tolerance by selection

    NASA Technical Reports Server (NTRS)

    Smith, A. H.

    1982-01-01

    A review is presented of experiments concerning the physiological consequences of chronic acceleration and of studies of selection for acceleration tolerance over many generations. It is shown that acceleration selection is effective in improving chronic acceleration tolerance. However, it is determined that the variable selection procedure employed in developing this acceleration-tolerant line limits the confidence in the quantitative evaluation of the procedure.

  20. Accelerating bioelectric functional development of neural stem cells by graphene coupling: Implications for neural interfacing with conductive materials.

    PubMed

    Guo, Rongrong; Zhang, Shasha; Xiao, Miao; Qian, Fuping; He, Zuhong; Li, Dan; Zhang, Xiaoli; Li, Huawei; Yang, Xiaowei; Wang, Ming; Chai, Renjie; Tang, Mingliang

    2016-11-01

    In order to govern cell-specific behaviors in tissue engineering for neural repair and regeneration, a better understanding of material-cell interactions, especially the bioelectric functions, is extremely important. Graphene has been reported to be a potential candidate for use as a scaffold and neural interfacing material. However, the bioelectric evolvement of cell membranes on these conductive graphene substrates remains largely uninvestigated. In this study, we used a neural stem cell (NSC) model to explore the possible changes in membrane bioelectric properties - including resting membrane potentials and action potentials - and cell behaviors on graphene films under both proliferation and differentiation conditions. We used a combination of single-cell electrophysiological recordings and traditional cell biology techniques. Graphene did not affect the basic membrane electrical parameters (capacitance and input resistance), but resting membrane potentials of cells on graphene substrates were more strongly negative under both proliferation and differentiation conditions. Also, NSCs and their progeny on graphene substrates exhibited increased firing of action potentials during development compared to controls. However, graphene only slightly affected the electric characterizations of mature NSC progeny. The modulation of passive and active bioelectric properties on the graphene substrate was accompanied by enhanced NSC differentiation. Furthermore, spine density, synapse proteins expressions and synaptic activity were all increased in graphene group. Modeling of the electric field on conductive graphene substrates suggests that the electric field produced by the electronegative cell membrane is much higher on graphene substrates than that on control, and this might explain the observed changes of bioelectric development by graphene coupling. Our results indicate that graphene is able to accelerate NSC maturation during development, especially with regard to

  1. Unconference session at the IAU General Assembly 2015

    NASA Astrophysics Data System (ADS)

    Nava, Tibisay Sankatsing; Venugopal, Ramasamy; Verdolini, Silvia

    2016-10-01

    The Astronomy For Development Focus Meeting 20 at the IAU General Assembly encompassed an `Unconference' session as part of the proceedings. Unstructured conferences, with their potential to unleash innovative ideas, are gaining traction in various conferences and symposia. Astronomy For Development is a field that is applicable to the entire Astronomy community (and even beyond) and hence an unconference inviting ideas and fostering frank dialogue is very pertinent. Officially one of the final sessions of the the 2015 General Assembly, the unconference session was intended to provide a balanced platform for a diverse set of participants and act as an informal setting to promote open discussion on topics of relevance to Astronomy for Development.

  2. Interactions of time of day and sleep with between-session habituation and extinction memory in young adult males.

    PubMed

    Pace-Schott, Edward F; Tracy, Lauren E; Rubin, Zoe; Mollica, Adrian G; Ellenbogen, Jeffrey M; Bianchi, Matt T; Milad, Mohammed R; Pitman, Roger K; Orr, Scott P

    2014-05-01

    Within-session habituation and extinction learning co-occur as do subsequent consolidation of habituation (i.e., between-session habituation) and extinction memory. We sought to determine whether, as we predicted: (1) between-session habituation is greater across a night of sleep versus a day awake; (2) time-of-day accounts for differences; (3) between-session habituation predicts consolidation of extinction memory; (4) sleep predicts between-session habituation and/or extinction memory. Participants (N = 28) completed 4-5 sessions alternating between mornings and evenings over 3 successive days (2 nights) with session 1 in either the morning (N = 13) or evening (N = 15). Twelve participants underwent laboratory polysomnography. During 4 sessions, participants completed a loud-tone habituation protocol, while skin conductance response (SCR), blink startle electromyography (EMG), heart-rate acceleration and heart-rate deceleration (HRD) were recorded. For sessions 1 and 2, between-session habituation of EMG, SCR and HRD was greater across sleep. SCR and HRD were generally lower in the morning. Between-session habituation of SCR for sessions 1 and 2 was positively related to intervening (first night) slow wave sleep. In the evening before night 2, participants also underwent fear conditioning and extinction learning phases of a second protocol. Extinction recall was tested the following morning. Extinction recall was predicted only by between-session habituation of SCR across the same night (second night) and by intervening REM. We conclude that: (1) sleep augments between-session habituation, as does morning testing; (2) extinction recall is predicted by concurrent between-session habituation; and (3) both phenomena may be influenced by sleep.

  3. US Particle Accelerators at Age 50.

    ERIC Educational Resources Information Center

    Wilson, R. R.

    1981-01-01

    Reviews the development of accelerators over the past 50 years. Topics include: types of accelerators, including cyclotrons; sociology of accelerators (motivation, financing, construction, and use); impact of war; national laboratories; funding; applications; future projects; foreign projects; and international collaborations. (JN)

  4. [Correlations of anthropometric and psychodynamic indexes of accelerant boys and girls (georgians) and their comparing with the data of women and men of normal physical development].

    PubMed

    Nadashvili, L A

    2005-12-01

    Our goal was to determine relations of anthropometric and psychodynamic indexes of accelerant women and men (Georgian) and compare them with the data of women and men of normal physical development. For this reason we have investigated 100 accelerants -- 45 girls and 55 boys. On the basis of our study we have shown that correlations between subspecies of temperament and anthropometrical signs in accelerant women and men are equal or lower among men. From the point of view of character form -- these data in women are comparatively high, and correlation of intellect and types of mood and anthropometric signs are equal. In comparison with the men of normal development, in accelerant men are noticed law interconnection between anthropometrical and psychodynamic data except subspecies of intellect, which is equal in every case. Connection between the types of mood and anthropometric data are moderate (in the limits 0.3-0.4). Men accelerants (Georgians) are brachymorphic somatotypes; they are distinguished by phlegmatic temperament, introversion, middle logic intellect, conflict -- statistic mood; according to the mood they are harmonic-dynamic constitutional types.

  5. Dreams that mirror the session.

    PubMed

    Civitarese, Giuseppe

    2006-06-01

    Dreams in which the analyst appears undisguised almost always depict violations of the setting. Often experienced as special, epiphanic moments, they give a glimpse of an intense, emotional reaction to traumatogenic or otherwise significant events that have occurred during the session or in the most recent previous ones. Probably, the essential aspect of these dreams can be found in the 'form of their content'. This may be paralleled by the narrative technique of mise en abyme or mirror-text. The dream appears as a story within the main story and the scene of the analysis is reflected anti-illusionistically. The fictional structure of the setting is emphasized. Its theatrical self-consciousness quality is revealed at its best. The author postulates that the transformative therapeutic value of these dreams derives from denouncing the referential illusion of 'concrete reality' and of 'what really happened'. For the analysand, they are an effective (i.e. emotionally intense) opportunity to discover the spatial articulations and the staggering refractions of the inside/outside, the textual/extra-textual, the psychic reality/material reality. In the continual comings and goings from one term to another, the work of symbolization is reactivated and the subject is constructed. Dreams that mirror the session, from this point of view, provide a model for conceptualizing the analytic work, and their significance goes beyond the specific phenomena referred to. A clinical case is given, in which some of one patient's dreams are considered as they occurred over a short period. In one of them, the dream-within-a-dream phenomenon is present.

  6. Session: Program Review X Wrap-Up

    SciTech Connect

    1992-01-01

    This wrap-up session at the Geothermal Energy Program Review X: Geothermal Energy and the Utility Market consisted of Closing Remarks by Roland R. Kessler and six NGA Industry Critique Panel presentations: ''Summary of Comments on DOE-Industry Cooperation by Geothermal Industry Panel'' by James B. Koenig, GeothermEx, Inc.; ''NGA Industry Critique of the Exploration Component'' by Joe L. Iovenitti, Weiss Associates; ''Critique of Drilling Research'' by Jerry Hamblin, UNOCAL Geothermal; ''Critique Panel Comments on Reservoir Engineering, DOE Geothermal Technology Development'' by Dennis Kaspereit, California Energy Company, Inc.; ''DOE Geothermal Program Review - Critique on Production'' by Douglas B. Jung, Two-Phase Engineering and Research; ''Comments on the DOE Hydrothermal Energy Conversion R&D Program'' by David L. Mendive, Geothermal Development Associates.

  7. Strategic HRD. [Concurrent Symposium Session at AHRD Annual Conference, 1998.

    ERIC Educational Resources Information Center

    1998

    This document contains four papers from a symposium on strategic human resource development (HRD). "The GEICO Challenge Session: A Model for Integrating Human Resource Development and Strategic Planning" (Clyde T. Conine, Jr., Bill P. Criswell) reports on a study that delineated the nature of the integration of HRD into the strategic…

  8. The Development of Biomedical Applications of Nuclear Physics Detector Technology at the Thomas Jefferson National Accelerator Facility

    NASA Astrophysics Data System (ADS)

    Weisenberger, Andrew

    2003-10-01

    The Southeastern Universities Research Association (SURA) operates the Thomas Jefferson National Accelerator Facility (Jefferson Lab) for the United States Department of Energy. As a user facility for physicists worldwide, its primary mission is to conduct basic nuclear physics research of the atom's nucleus at the quark level. Within the Jefferson Lab Physics Division is the Jefferson Lab Detector Group which was formed to support the design and construction of new detector systems during the construction phase of the major detector systems at Jefferson Lab and to act as technical consultants for the lab scientists and users. The Jefferson Lab Detector Group, headed by Dr. Stan Majewski, has technical capabilities in the development and use of radiation detection systems. These capabilities include expertise in nuclear particle detection through the use of gas detectors, scintillation and light guide techniques, standard and position-sensitive photomultiplier tubes (PSPMTs), fast analog readout electronics and data acquisition, and on-line image formation and analysis. In addition to providing nuclear particle detector support to the lab, the group has for several years (starting in 1996) applied these technologies to the development of novel high resolution gamma-ray imaging systems for biomedical applications and x-ray imaging techniques. The Detector Group has developed detector systems for breast cancer detection, brain cancer therapy and small animal imaging to support biomedical research. An overview will be presented of how this small nuclear physics detector research group by teaming with universities, medical facilities, industry and other national laboratories applies technology originating from basic nuclear physics research to biomedical applications.

  9. Overexpression of complement component C5a accelerates the development of atherosclerosis in ApoE-knockout mice

    PubMed Central

    An, Guipeng; Li, Bo; Liu, Xiaoman; Zhang, Mingxiang; Gao, Fei; Zhao, Yuxia; An, Fengshuang; Zhang, Yun; Zhang, Cheng

    2016-01-01

    Background In this study, we investigated the direct effect of C5a overexpression on atherosclerosis. Methods and Results A recombinant adenovirus expressing mouse C5a (Ad-C5a) was constructed and injected intravenously into ApoE−/− mice. After 12 weeks of a high-fat diet, Ad-C5a injection produced more extensive lesions than control adenovirus, and its proathrosclerotic role was significantly blocked by C5a receptor antagonist. Immunohistochemical analysis showed enhanced macrophage infiltration in atherosclerotic regions with C5a overexpression. Trans-well assay revealed C5a receptor-dependent chemotaxis of C5a to macrophages. Furthermore, Ad-C5a overexpression promoted foam cell formation and lipid deposition but reduced collagen content. In addition, with Ad-C5a overexpression, the serum levels of interleukin 6 and tumor necrosis factor α were upregulated. Conclusions C5a overexpression could accelerate the development of atherosclerosis in ApoE−/− mice by promoting macrophage recruitment, foam cell formation and inflammatory activation. Furthermore, its proatherogetic role is mediated by the C5a receptor. PMID:27517153

  10. PARK2 deletions occur frequently in sporadic colorectal cancer and accelerate adenoma development in Apc mutant mice.

    PubMed

    Poulogiannis, George; McIntyre, Rebecca E; Dimitriadi, Maria; Apps, John R; Wilson, Catherine H; Ichimura, Koichi; Luo, Feijun; Cantley, Lewis C; Wyllie, Andrew H; Adams, David J; Arends, Mark J

    2010-08-24

    In 100 primary colorectal carcinomas, we demonstrate by array comparative genomic hybridization (aCGH) that 33% show DNA copy number (DCN) loss involving PARK2, the gene encoding PARKIN, the E3 ubiquitin ligase whose deficiency is responsible for a form of autosomal recessive juvenile parkinsonism. PARK2 is located on chromosome 6 (at 6q25-27), a chromosome with one of the lowest overall frequencies of DNA copy number alterations recorded in colorectal cancers. The PARK2 deletions are mostly focal (31% approximately 0.5 Mb on average), heterozygous, and show maximum incidence in exons 3 and 4. As PARK2 lies within FRA6E, a large common fragile site, it has been argued that the observed DCN losses in PARK2 in cancer may represent merely the result of enforced replication of locally vulnerable DNA. However, we show that deficiency in expression of PARK2 is significantly associated with adenomatous polyposis coli (APC) deficiency in human colorectal cancer. Evidence of some PARK2 mutations and promoter hypermethylation is described. PARK2 overexpression inhibits cell proliferation in vitro. Moreover, interbreeding of Park2 heterozygous knockout mice with Apc(Min) mice resulted in a dramatic acceleration of intestinal adenoma development and increased polyp multiplicity. We conclude that PARK2 is a tumor suppressor gene whose haploinsufficiency cooperates with mutant APC in colorectal carcinogenesis.

  11. Development of a lifetime prediction model for lithium-ion batteries based on extended accelerated aging test data

    NASA Astrophysics Data System (ADS)

    Ecker, Madeleine; Gerschler, Jochen B.; Vogel, Jan; Käbitz, Stefan; Hust, Friedrich; Dechent, Philipp; Sauer, Dirk Uwe

    2012-10-01

    Battery lifetime prognosis is a key requirement for successful market introduction of electric and hybrid vehicles. This work aims at the development of a lifetime prediction approach based on an aging model for lithium-ion batteries. A multivariable analysis of a detailed series of accelerated lifetime experiments representing typical operating conditions in hybrid electric vehicle is presented. The impact of temperature and state of charge on impedance rise and capacity loss is quantified. The investigations are based on a high-power NMC/graphite lithium-ion battery with good cycle lifetime. The resulting mathematical functions are physically motivated by the occurring aging effects and are used for the parameterization of a semi-empirical aging model. An impedance-based electric-thermal model is coupled to the aging model to simulate the dynamic interaction between aging of the battery and the thermal as well as electric behavior. Based on these models different drive cycles and management strategies can be analyzed with regard to their impact on lifetime. It is an important tool for vehicle designers and for the implementation of business models. A key contribution of the paper is the parameterization of the aging model by experimental data, while aging simulation in the literature usually lacks a robust empirical foundation.

  12. Development of a 15 T Nb3Sn accelerator dipole demonstrator at Fermilab

    SciTech Connect

    Novitski, I.; Andreev, N.; Barzi, E.; Carmichael, J.; Kashikhin, V. V.; Turrioni, D.; Yu, M.; Zlobin, A. V.

    2016-06-01

    Here, a 100 TeV scale Hadron Collider (HC) with a nominal operation field of at least 15 T is being considered for the post-LHC era, which requires using the Nb3Sn technology. Practical demonstration of this field level in an accelerator-quality magnet and substantial reduction of the magnet costs are the key conditions for realization of such a machine. FNAL has started the development of a 15 T Nb3Sn dipole demonstrator for a 100 TeV scale HC. The magnet design is based on 4-layer shell type coils, graded between the inner and outer layers to maximize the performance and reduce the cost. The experience gained during the Nb3Sn magnet R&D is applied to different aspects of the magnet design. This paper describes the magnetic and structural designs and parameters of the 15 T Nb3Sn dipole and the steps towards the demonstration model fabrication.

  13. Oversight: biomass. Hearing before the Subcommittee on Energy Development and Applications of the Committee on Science and Technology, US House of Representatives, Ninety-sixth Congress, Second Session, March 10, 1980

    SciTech Connect

    Not Available

    1980-01-01

    Testimony from a number of public witnesses concerning various biomass-production systems that facilitate the forest and agricultural lands for energy crops and conversion technologies that convert biomass to gaseous and liquid fuels was presented. Biomass will make a significant contribution to the administration's goal of 20% solar by the year 2000. The Department of Energy's budget calls for a $13 million reduction in biomass gasification which is the preliminary step in the production of methanol. Witnesses were asked to comment on that reduction. What it will take to convert less-expensive cellulosic feedstocks into ethanol for blending into gasohol and efforts to accelerate the use of wood for near-term contributions are also discussed. The possibility of increased use of forest and agricultural lands for producing energy-related crops and the program to develop hydrocarbon from palm trees and alcohol from cassava and sugar are also examined.

  14. Oversight: biomass. Hearing before the Subcommittee on Energy Development and Applications of the Committee on Science and Technology, US House of Representatives, Ninety-Sixth Congress, Second Session, March 10, 1980

    SciTech Connect

    Not Available

    1980-01-01

    Testimony from a number of public witnesses concerning various biomass-production systems that facilitate the forest and agricultural lands for energy crops and conversion technologies that convert biomass to gaseous and liquid fuels was presented. Biomass will make a significant contribution to the administration's goal of 20% solar by the year 2000. The Department of Energy's budget calls for a $13 million reduction in biomass gasification which is the preliminary step in the production of methanol. Witnesses were asked to comment on that reduction. What it will take to convert less-expensive cellulosic feedstocks into ethanol for blending into gasohol and efforts to accelerate the use of wood for near-term contributions are also discussed. The possibility of increased use of forest and agricultural lands for producing energy-related crops and the program to develop hydrocarbon from palm trees and alcohol from cassava and sugar are also examined. (MCW)

  15. LINEAR ACCELERATOR

    DOEpatents

    Colgate, S.A.

    1958-05-27

    An improvement is presented in linear accelerators for charged particles with respect to the stable focusing of the particle beam. The improvement consists of providing a radial electric field transverse to the accelerating electric fields and angularly introducing the beam of particles in the field. The results of the foregoing is to achieve a beam which spirals about the axis of the acceleration path. The combination of the electric fields and angular motion of the particles cooperate to provide a stable and focused particle beam.

  16. Induction linear accelerators

    NASA Astrophysics Data System (ADS)

    Birx, Daniel

    1992-03-01

    Among the family of particle accelerators, the Induction Linear Accelerator is the best suited for the acceleration of high current electron beams. Because the electromagnetic radiation used to accelerate the electron beam is not stored in the cavities but is supplied by transmission lines during the beam pulse it is possible to utilize very low Q (typically<10) structures and very large beam pipes. This combination increases the beam breakup limited maximum currents to of order kiloamperes. The micropulse lengths of these machines are measured in 10's of nanoseconds and duty factors as high as 10-4 have been achieved. Until recently the major problem with these machines has been associated with the pulse power drive. Beam currents of kiloamperes and accelerating potentials of megavolts require peak power drives of gigawatts since no energy is stored in the structure. The marriage of liner accelerator technology and nonlinear magnetic compressors has produced some unique capabilities. It now appears possible to produce electron beams with average currents measured in amperes, peak currents in kiloamperes and gradients exceeding 1 MeV/meter, with power efficiencies approaching 50%. The nonlinear magnetic compression technology has replaced the spark gap drivers used on earlier accelerators with state-of-the-art all-solid-state SCR commutated compression chains. The reliability of these machines is now approaching 1010 shot MTBF. In the following paper we will briefly review the historical development of induction linear accelerators and then discuss the design considerations.

  17. Development and Initial Validation of the Student Rating of Environmental Stressors Scale: Stressors Faced by Students in Accelerated High School Curricula

    ERIC Educational Resources Information Center

    Suldo, Shannon M.; Dedrick, Robert F.; Shaunessy-Dedrick, Elizabeth; Roth, Rachel A.; Ferron, John

    2015-01-01

    High school students in accelerated curricula face stressors beyond typical adolescent developmental challenges. The Student Rating of Environmental Stressors Scale (StRESS) is a self-report measure of environmental stressors appropriate for students in Advanced Placement (AP) and International Baccalaureate (IB) courses. We developed the StRESS…

  18. DREAMING THE ANALYTIC SESSION: A CLINICAL ESSAY.

    PubMed

    Ogden, Thomas H

    2017-01-01

    This is a clinical paper in which the author describes analytic work in which he dreams the analytic session with three of his patients. He begins with a brief discussion of aspects of analytic theory that make up a good deal of the context for his clinical work. Central among these concepts are (1) the idea that the role of the analyst is to help the patient dream his previously "undreamt" and "interrupted" dreams; and (2) dreaming the analytic session involves engaging in the experience of dreaming the session with the patient and, at the same time, unconsciously (and at times consciously) understanding the dream. The author offers no "technique" for dreaming the analytic session. Each analyst must find his or her own way of dreaming each session with each patient. Dreaming the session is not something one works at; rather, one tries not to get in its way.

  19. Utilization of Practice Session Average Inertial Load to Quantify College Football Injury Risk.

    PubMed

    Wilkerson, Gary B; Gupta, Ashish; Allen, Jeff R; Keith, Clay M; Colston, Marisa A

    2016-09-01

    Wilkerson, GB, Gupta, A, Allen, JR, Keith, CM, and Colston, MA. Utilization of practice session average inertial load to quantify college football injury risk. J Strength Cond Res 30(9): 2369-2374, 2016-Relatively few studies have investigated the potential injury prevention value of data derived from recently developed wearable technology for measurement of body mass accelerations during the performance of sport-related activities. The available evidence has been derived from studies focused on avoidance of overtraining syndrome, which is believed to induce a chronically fatigued state that can be identified through monitoring of inertial load accumulation. Reduced variability in movement patterns is also believed to be an important injury risk factor, but no evidence currently exists to guide interpretation of data derived from inertial measurement units (IMUs) in this regard. We retrospectively analyzed archived data for a cohort of 45 National Collegiate Athletic Association Division 1-football bowl subdivision football players who wore IMUs on the upper back during practice sessions to quantify any associations between average inertial load measured during practice sessions and occurrence of musculoskeletal sprains and strains. Both the coefficient of variation for average inertial load and frequent exposure to game conditions were found to be strongly associated with injury occurrence. Having either or both of the 2 risk factors provided strong discrimination between injured and noninjured players (χ = 9.048; p = 0.004; odds ratio = 8.04; 90% CI: 2.39, 27.03). Our findings may facilitate identification of individual football players who are likely to derive the greatest benefit from training activities designed to reduce injury risk through improved adaptability to rapidly changing environmental demands.

  20. Anchor-Less Secure Session Mobility

    NASA Astrophysics Data System (ADS)

    Zugenmaier, Alf; Laganier, Julien; Prasad, Anand; Slavov, Kristian

    Communication session mobility relates transferring one endpoint of a communication session including its state from one device to another. Current proposals to deal with this securely require an anchor. We propose an anchor-less solution that takes some ideas from the host identity protocol. We then show how the idea of transferring endpoints simultaneously can be tackled without introducing timeouts as the session initiation protocol currently does.

  1. Science and Technology of Accelerators

    NASA Astrophysics Data System (ADS)

    Valerio Lizarraga, Cristhian; Castilla Loaeza, Alejandro; Guillermo Cantón, Gerardo; Duarte, Carlos; Chavez Valenzuela, Daniel; Hernández Chahín, Karim; Cuna, Humberto Maury; Medina Medrano, Luis; Reyes Herrera, Juan; Sosa Güitrón, Salvador; Valdivia García, Alan; Rendón, Bruce Yee

    2016-10-01

    The Mexican Particle Accelerator Community (CMAP) was created in 2015 and currently its members participate in different experiments around the world. Using their expertise, they are working in the development of the particle accelerators area in Mexico. This paper provides a summary of the research done by its members and presents the preliminary design of an electron linear particle accelerator (eLINAC). This proposal will be the first accelerator designed and created in Mexico.

  2. GPU-Accelerated Monte Carlo Electron Transport Methods: Development and Application for Radiation Dose Calculations Using Six GPU cards

    NASA Astrophysics Data System (ADS)

    Su, Lin; Du, Xining; Liu, Tianyu; Xu, X. George

    2014-06-01

    An electron-photon coupled Monte Carlo code ARCHER - Accelerated Radiation-transport Computations in Heterogeneous EnviRonments - is being developed at Rensselaer Polytechnic Institute as a software testbed for emerging heterogeneous high performance computers that utilize accelerators such as GPUs. This paper presents the preliminary code development and the testing involving radiation dose related problems. In particular, the paper discusses the electron transport simulations using the class-II condensed history method. The considered electron energy ranges from a few hundreds of keV to 30 MeV. For photon part, photoelectric effect, Compton scattering and pair production were modeled. Voxelized geometry was supported. A serial CPU code was first written in C++. The code was then transplanted to the GPU using the CUDA C 5.0 standards. The hardware involved a desktop PC with an Intel Xeon X5660 CPU and six NVIDIA Tesla™ M2090 GPUs. The code was tested for a case of 20 MeV electron beam incident perpendicularly on a water-aluminum-water phantom. The depth and later dose profiles were found to agree with results obtained from well tested MC codes. Using six GPU cards, 6x106 electron histories were simulated within 2 seconds. In comparison, the same case running the EGSnrc and MCNPX codes required 1645 seconds and 9213 seconds, respectively. On-going work continues to test the code for different medical applications such as radiotherapy and brachytherapy.

  3. Development and practical application of accelerated solvent extraction for the isolation of cocaine/crack biomarkers in meconium samples.

    PubMed

    Mantovani, Cínthia de Carvalho; Lima, Marcela Bittar; Oliveira, Carolina Dizioli Rodrigues de; Menck, Rafael de Almeida; Diniz, Edna Maria de Albuquerque; Yonamine, Mauricio

    2014-04-15

    A method using accelerated solvent extraction (ASE) for the isolation of cocaine/crack biomarkers in meconium samples, followed by solid phase extraction (SPE) and the simultaneous quantification by gas chromatography-mass spectrometry (GC-MS) was developed and validated. Initially, meconium samples were submitted to an ASE procedure, which was followed by SPE with Bond Elut Certify I cartridges. The analytes were derivatizated with PFP/PFPA and analyzed by GC-MS. The limits of detection (LOD) were between 11 and 17ng/g for all analytes. The limits of quantification (LOQ) were 30ng/g for anhydroecgonine methyl ester, and 20ng/g for cocaine, benzoylecgonine, ecgonine methyl ester and cocaethylene. Linearity ranged from the LOQ to 1500ng/g for all analytes, with a coefficients of determination greater than 0.991, except for m-hydroxybenzoylecgonine, which was only qualitatively detected. Precision and accuracy were evaluated at three concentration levels. For all analytes, inter-assay precision ranged from 3.2 to 18.1%, and intra-assay precision did not exceed 12.7%. The accuracy results were between 84.5 and 114.2% and the average recovery ranged from 17 to 84%. The method was applied to 342 meconium samples randomly collected in the University Hospital-University of São Paulo (HU-USP), Brazil. Cocaine biomarkers were detected in 19 samples, which represent 5.6% of exposure prevalence. Significantly lower birth weight, length and head circumference were found for the exposed newborns compared with the non-exposed group. This is the first report in which ASE was used as a sample preparation technique to extract cocaine biomarkers from a complex biological matrix such as meconium samples. The advantages of the developed method are the smaller demand for organic solvents and the minor sample handling, which allows a faster and accurate procedure, appropriate to confirm fetal exposure to cocaine/crack.

  4. Accelerated dendritic development of rat cortical pyramidal cells and interneurons after biolistic transfection with BDNF and NT4/5.

    PubMed

    Wirth, Marcus J; Brun, Annika; Grabert, Jochen; Patz, Silke; Wahle, Petra

    2003-12-01

    Neurotrophins are candidate molecules for regulating dendritogenesis. We report here on dendritic growth of rat visual cortex pyramidal and interneurons overexpressing 'brain-derived neurotrophic factor' BDNF and 'neurotrophin 4/5' NT4/5. Neurons in organotypic cultures were transfected with plasmids encoding either 'enhanced green fluorescent protein' EGFP, BDNF/EGFP or NT4/5/EGFP either at the day of birth with analysis at 5 days in vitro, or at 5 days in vitro with analysis at 10 days in vitro. In pyramidal neurons, both TrkB ligands increased dendritic length and number of segments without affecting maximum branch order and number of primary dendrites. In the early time window, only infragranular neurons were responsive. Neurons in layers II/III became responsive to NT4/5, but not BDNF, during the later time window. BDNF and NT4/5 transfectants at 10 days in vitro had still significantly shorter dendrites than adult pyramidal neurons, suggesting a massive growth spurt after 10 days in vitro. However, segment numbers were already in the range of adult neurons. Although this suggested a role for BDNF, long-term activity-deprived, and thus BDNF-deprived, pyramidal cells developed a dendritic complexity not different from neurons in active cultures except for higher spine densities on neurons of layers II/III and VI. Neutralization of endogenous NT4/5 causes shorter and less branched dendrites at 10 days in vitro suggesting an essential role for NT4/5. Neutralization of BDNF had no effect. Transfected multipolar interneurons became identifiable during the second time window. Both TrkB ligands significantly increased number of segments and branch order towards the adult state with little effects on dendritic length. The results suggested that early in development BDNF and NT4/5 probably accelerate dendritogenesis in an autocrine fashion. In particular, branch formation was advanced towards the adult pattern in pyramidal cells and interneurons.

  5. Acceleration switch

    DOEpatents

    Abbin, Jr., Joseph P.; Devaney, Howard F.; Hake, Lewis W.

    1982-08-17

    The disclosure relates to an improved integrating acceleration switch of the type having a mass suspended within a fluid filled chamber, with the motion of the mass initially opposed by a spring and subsequently not so opposed.

  6. Acceleration switch

    DOEpatents

    Abbin, J.P. Jr.; Devaney, H.F.; Hake, L.W.

    1979-08-29

    The disclosure relates to an improved integrating acceleration switch of the type having a mass suspended within a fluid filled chamber, with the motion of the mass initially opposed by a spring and subsequently not so opposed.

  7. ION ACCELERATOR

    DOEpatents

    Bell, J.S.

    1959-09-15

    An arrangement for the drift tubes in a linear accelerator is described whereby each drift tube acts to shield the particles from the influence of the accelerating field and focuses the particles passing through the tube. In one embodiment the drift tube is splii longitudinally into quadrants supported along the axis of the accelerator by webs from a yoke, the quadrants. webs, and yoke being of magnetic material. A magnetic focusing action is produced by energizing a winding on each web to set up a magnetic field between adjacent quadrants. In the other embodiment the quadrants are electrically insulated from each other and have opposite polarity voltages on adjacent quadrants to provide an electric focusing fleld for the particles, with the quadrants spaced sufficienily close enough to shield the particles within the tube from the accelerating electric field.

  8. Invited Review Article: "Hands-on" laser-driven ion acceleration: A primer for laser-driven source development and potential applications

    NASA Astrophysics Data System (ADS)

    Schreiber, J.; Bolton, P. R.; Parodi, K.

    2016-07-01

    An overview of progress and typical yields from intense laser-plasma acceleration of ions is presented. The evolution of laser-driven ion acceleration at relativistic intensities ushers prospects for improved functionality and diverse applications which can represent a varied assortment of ion beam requirements. This mandates the development of the integrated laser-driven ion accelerator system, the multiple components of which are described. Relevant high field laser-plasma science and design of controlled optimum pulsed laser irradiation on target are dominant single shot (pulse) considerations with aspects that are appropriate to the emerging petawatt era. The pulse energy scaling of maximum ion energies and typical differential spectra obtained over the past two decades provide guidance for continued advancement of laser-driven energetic ion sources and their meaningful applications.

  9. LINEAR ACCELERATOR

    DOEpatents

    Christofilos, N.C.; Polk, I.J.

    1959-02-17

    Improvements in linear particle accelerators are described. A drift tube system for a linear ion accelerator reduces gap capacity between adjacent drift tube ends. This is accomplished by reducing the ratio of the diameter of the drift tube to the diameter of the resonant cavity. Concentration of magnetic field intensity at the longitudinal midpoint of the external sunface of each drift tube is reduced by increasing the external drift tube diameter at the longitudinal center region.

  10. Final Report on "Development and Testing of Advanced Accelerator Structures and Technologies at 11.424 GHz"

    SciTech Connect

    Gold, Steven H.

    2013-10-13

    This is the final report on the research program ?Development and Testing of Advanced Accelerator Structures and Technologies at 11.424 GHz,? which was carried out by the Naval Research Laboratory (NRL) under Interagency Agreement DE?AI02?01ER41170 with the Department of Energy. The period covered by this report is 15 July 2010 ? 14 July 2013. The program included two principal tasks. Task 1 involved a study of the key physics issues related to the use of high gradient dielectric-loaded accelerating (DLA) structures in rf linear accelerators and was carried out in collaboration with Argonne National Laboratory (ANL) and Euclid Techlabs LLC. Task 2 involved a study of high power active microwave pulse compressors and was carried out in collaboration with Omega-P, Inc. and the Institute of Applied Physics of the Russian Academy of Sciences in Nizhny Novgorod. The studies under Task 1 were focused on rf-induced multipactor and breakdown in externally driven DLA structures at the 200-ns timescale. Suppression of multipactor and breakdown are essential to the practical application of dielectric structures in rf linear accelerators. The structures that were studied were developed by ANL and Euclid Techlabs and their performance was evaluated at high power in the X-band Magnicon Laboratory at NRL. Three structures were designed, fabricated, and tested, and the results analyzed in the first two years of the program: a clamped quartz traveling-wave (TW) structure, a externally copper-coated TW structure, and an externally copper-coated dielectric standing-wave (SW) structure. These structures showed that rf breakdown could be largely eliminated by eliminating dielectric joints in the structures, but that the multipactor loading was omnipresent. In the third year of the program, the focus of the program was on multipactor suppression using a strong applied axial magnetic field, as proposed by Chang et al. [C. Chang et al., J. Appl. Phys. 110, 063304 (2011).], and a

  11. Cosmic Ray Origin, Acceleration and Propagation

    NASA Technical Reports Server (NTRS)

    Baring, Matthew G.

    2000-01-01

    This paper summarizes highlights of the OG3.1, 3.2 and 3.3 sessions of the 26th International Cosmic Ray Conference in Salt Lake City, which were devoted to issues of origin/composition, acceleration and propagation.

  12. Session duration and the VI response function: Within-session prospective and retrospective effects

    PubMed Central

    Dougan, James D.; Kuh, J. Alfred; Vink, K. L.

    1993-01-01

    Two experiments examined the effects of session duration on responding during simple variable-interval schedules. In Experiment 1, rats were exposed to a series of simple variable-interval schedules differing in both session duration (10 min or 30 min) and scheduled reinforcement rate (7.5 s, 15 s, 30 s, and 480 s). The functions relating response rate to reinforcement rate were predominantly monotonic for the short (10-min) sessions but were predominantly bitonic for the long (30-min) sessions, when data from the entire session were considered. Examination of responding within sessions suggested that differences in the whole-session data were produced by a combination of prospective processes (i.e., processes based on events scheduled to occur later in the session) and retrospective processes (i.e., processes based on events that had already occurred in the session). In Experiment 2, rats were exposed to a modified discrimination procedure in which pellet flavor (standard or banana) predicted session duration (10 min or 30 min). All rats came to respond faster during the short (10-min) sessions than during the first 10 min of the long sessions. As in Experiment 1, the results seemed to reflect the simultaneous operation of both prospective and retrospective processes. The results shed light on the recent controversy over the form of the variable-interval response function by identifying one variable (session duration) and two types of processes (prospective and retrospective) that influence responding on these schedules. PMID:16812719

  13. Synchrony in Dyadic Psychotherapy Sessions

    NASA Astrophysics Data System (ADS)

    Ramseyer, Fabian; Tschacher, Wolfgang

    Synchrony is a multi-faceted concept used in diverse domains such as physics, biology, and the social sciences. This chapter reviews some of the evidence of nonverbal synchrony in human communication, with a main focus on the role of synchrony in the psychotherapeutic setting. Nonverbal synchrony describes coordinated behavior of patient and therapist. Its association with empathy, rapport and the therapeutic relationship has been pointed out repeatedly, yet close evaluation of empirical studies suggests that the evidence remains inconclusive. Particularly in naturalistic studies, research with quantitative measures of synchrony is still lacking. We introduce a new empirical approach for the study of synchrony in psychotherapies under field conditions: Motion Energy Analysis (MEA). This is a video-based algorithm that quantifies the amount of movement in freely definable regions of interest. Our statistical analysis detects synchrony on a global level, irrespective of the specific body parts moving. Synchrony thus defined can be considered as a general measure of movement coordination between interacting individuals. Data from a sequence of N = 21 therapy sessions taken from one psychotherapy dyad shows a high positive relationship between synchrony and the therapeutic bond. Nonverbal synchrony can thus be considered a promising concept for research on the therapeutic alliance. Further areas of application are discussed.

  14. Scaling FFAG accelerator for muon acceleration

    SciTech Connect

    Lagrange, JB.; Planche, T.; Mori, Y.

    2011-10-06

    Recent developments in scaling fixed field alternating gradient (FFAG) accelerators have opened new ways for lattice design, with straight sections, and insertions like dispersion suppressors. Such principles and matching issues are detailed in this paper. An application of these new concepts is presented to overcome problems in the PRISM project.

  15. Scaling FFAG accelerator for muon acceleration

    NASA Astrophysics Data System (ADS)

    Lagrange, JB.; Planche, T.; Mori, Y.

    2011-10-01

    Recent developments in scaling fixed field alternating gradient (FFAG) accelerators have opened new ways for lattice design, with straight sections, and insertions like dispersion suppressors. Such principles and matching issues are detailed in this paper. An application of these new concepts is presented to overcome problems in the PRISM project.

  16. Sessions on history of space and geophysics spark interest

    NASA Astrophysics Data System (ADS)

    Schröder, Wilfried

    Three sessions at international conferences were held in 1997 to discuss the history of space and geophysics and its different disciplines. The first session was held during the Assembly of the German Geophysical Society in March in Potsdam, Germany. Topics included the theory of relativity and gravitation in geophysics; work by Albert Abraham Michelson, Leon Foucault, and Ernst Mach; work by Hermann von Helmholtz; and the physical application and geophysical evidence of Werner Heisenberg's research. Also included were discussions relevant to the history of geophysics, aeronomy, meteor astronomy, and geodetical research, including developments in instrumentation during the last few decades.

  17. Scanning Our Future. A Report from the NGO Forum on the World Economic Order in Support of the Seventh Special Session of the UN General Assembly on Development and International Economic Cooperation (September 1-12, 1975).

    ERIC Educational Resources Information Center

    Archer, Angus, Ed.

    This report of the Seventh Special Session at the Conference of Non-Governmental Organizations (NGOs) presents an account of the Forum on World Economic Order. Its purpose is to gain public awareness of the issues debated. The core of this report is the unique exchange of over 50 opinions which provide a compendium of ideas and judgments in the…

  18. A Descriptive Analysis of Test Session Observation Checklist Ratings from the Woodcock Johnson III Standardization Sample

    ERIC Educational Resources Information Center

    Frisby, Craig L.; Osterlind, Steven J.

    2006-01-01

    Modern scale construction techniques have been used to develop scales measuring examiner ratings of examinees' test session behavior (TSB) on Wechsler and Stanford-Binet intelligence tests. This study analyzes data from the Test Session Observation Checklist (TSOC), a measure developed by post hoc rational analysis, from a portion of the Woodcock…

  19. The KEK Digital Accelerator and Its Brothers

    NASA Astrophysics Data System (ADS)

    Takayama, Ken

    Circular induction accelerators developed in the last 10 years are discussed. They are characterized by induction acceleration of a charged beam bunch trapped in the barrier bucket. This property enables acceleration of any ion species from an extremely low energy to relativistic energy in a single accelerator ring. In the future, a racetrack-shaped fixed field induction accelerator (induction microtron) could be realized as a unique accelerator for cluster ions such as C-60 and Si-100.

  20. CEBAF Accelerator Achievements

    NASA Astrophysics Data System (ADS)

    Chao, Y. C.; Drury, M.; Hovater, C.; Hutton, A.; Krafft, G. A.; Poelker, M.; Reece, C.; Tiefenback, M.

    2011-05-01

    In the past decade, nuclear physics users of Jefferson Lab's Continuous Electron Beam Accelerator Facility (CEBAF) have benefited from accelerator physics advances and machine improvements. As of early 2011, CEBAF operates routinely at 6 GeV, with a 12 GeV upgrade underway. This article reports highlights of CEBAF's scientific and technological evolution in the areas of cryomodule refurbishment, RF control, polarized source development, beam transport for parity experiments, magnets and hysteresis handling, beam breakup, and helium refrigerator operational optimization.