Science.gov

Sample records for accelerated development sessions

  1. 76 FR 28988 - Medicare Program; Accelerated Development Sessions for Accountable Care Organizations-June 20, 21...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-19

    ... Sessions for Accountable Care Organizations--June 20, 21, and 22, 2011 AGENCY: Centers for Medicare... functions of an Accountable Care Organization (ACO) and ways to build their organization's capacity to succeed as an ACO. This 3-day, in-person ADS is to help new ACOs deliver better care and reduce costs....

  2. Summary of the electron accelerators session

    SciTech Connect

    Prescott, C.Y.

    1988-10-01

    Since the last High Energy Physics Symposium, there has been considerable progress in the field of polarized electron accelerators. Projects well into construction include the SLC, HERA, and LEP. The status of polarized beams for these projects is discussed in this session. Semiclassical and quantum mechanical calculations of polarizing and depolarizing effects are discussed, for both linear colliders and for storage rings. Substantial progress is continuing in the understanding of depolarizing mechanisms for circular machines. Modelling of these machines is underway. Activities with polarized electron beams at Novosibirsk are described. 8 refs.

  3. Session: Wind industry project development

    SciTech Connect

    Gray, Tom; Enfield, Sam

    2004-09-01

    This first session at the Wind Energy and Birds/Bats workshop consisted of two presentations followed by a question and answer period. The session was intended to provide a general overview of wind energy product development, from the industry's perspective. Tom Gray of AWEA presented a paper titled ''State of the Wind Energy Industry in 2004'', highlighting improved performance and lower cost, efforts to address avian impacts, a status of wind energy in comparison to other energy-producing sources, and ending on expectations for the near future. Sam Enfield of Atlantic Renewable Energy Corporation presented a paper titled ''Key Factors for Consideration in Wind Plant Siting'', highlighting factors that wind facility developers must consider when choosing a site to build wind turbines and associated structures. Factors covered include wind resources available, ownership and land use patterns, access to transmission lines, accessibility and environmental impacts. The question and answer sum mary included topics related to risk taking, research and development, regulatory requirements, and dealing with utilities.

  4. Session 19: Geothermal Materials Development

    SciTech Connect

    van Rooyen, Daniel

    1983-12-01

    Among the most pressing problems constraining the development of geothermal energy is the lack of satisfactory component and system reliability. This is due to the unavailability, on a commercial scale, of cost-effective materials that can function in a wide range of geothermal environments and to the unavailability of a comprehensive body of directly related test data or materials selection experience. In 1976, the GHTD started the Geothermal Materials Program to address materials-related problems, and since 1978 Brookhaven National Laboratory has provided technical and managerial assistance in the implementation of the effort. Major successes have been attained in the development of elastomers for high-temperature applications and in the use of polymer concrete liners for corrosion protection. Both technologies have been successfully transferred to industry. Current efforts in metallic and nonmetallic materials development and corrosion protection will be summarized. In the metals area, testing of a series of experimental stainless steels has led to compositions which show a very remarkable resistance to pitting corrosion in hot chloride electrolytes. Combinations of molybdenum and nitrogen are very beneficial. Alternate materials for line shaft pump bearings have been identified through tests in simulated hot brine. Cermets and carbides show promise of extending pump life. A series of drill bit steels has been examined for fatigue and hot fracture toughness. The work has indicated alloys with properties that exceed those of materials now in use. A major finding in the nonmetallic materials area has been the development of fluorinated elastomers for use in statis seals at temperatures greater than 300 C. Field testing has just commenced, but based upon laboratory results, the work is very promising. Commercialization of this material is underway. Technology transfer of a 240 C EPDM was completed earlier. Field testing of polymer concrete-lined pipe has been

  5. Special Session: Astronomy for Developing Countries

    NASA Astrophysics Data System (ADS)

    Batten, A. H.

    A Special Session was held during the XXIV General Assembly on the topic "Astronomy for Developing Countries". During two-and-a-half days, thirty-eight oral papers were presented and a similar number of poster papers were displayed. Edited summaries of the oral papers are presented here. Full texts of those papers and abstracts of the posters appear in a separate volume published in 2001 by the ASP.

  6. Developing assessment: involving the sessional clinical teacher.

    PubMed

    Bateman, H; Thomason, J M; McCracken, G; Ellis, J

    2016-02-12

    Assessment development is a fundamental element of curriculum management and a requirement for providers of education to consistently demonstrate attainment of educational standards. Development of authentic, valid and reliable assessment is, however, both challenging and resource intensive. In the UK, dental education standards are regulated by the General Dental Council (GDC). The 'safe beginner' is the threshold determined by the GDC for the passing student - but how do we apply this? This article describes an approach the School of Dental Sciences at Newcastle University has adopted to address the challenges associated with developing assessments. Sessional clinical teachers contribute a significant proportion of the clinical supervision within the BDS programme and also have a good appreciation of both the standard and concept of the 'safe beginner'. By implementing a process of active timetable management, we have identified time where this group could contribute to assessment development. We believe that aspects, which could be enhanced by their involvement, include writing, validation, standard-setting and utilisation of assessment. To achieve this, we recognise a requirement for investment in careful manpower planning and training, but consider that it is realistic and beneficial to include sessional clinical teachers in this essential part of learning and teaching. PMID:26868802

  7. Session: Pre-development project risk assessment

    SciTech Connect

    Curry, Richard; Linehan, Andy

    2004-09-01

    This second session at the Wind Energy and Birds/Bats workshop consisted of two presentations followed by a discussion/question and answer period. The focus of the presentations was on the practices and methodologies used in the wind energy industry for assessing risk to birds and bats at candidate project sites. Presenters offered examples of pre-development siting evaluation requirements set by certain states. Presentation one was titled ''Practices and Methodologies and Initial Screening Tools'' by Richard Curry of Curry and Kerlinger, LLC. Presentation two was titled ''State of the Industry in the Pacific Northwest'' by Andy Linehan, CH2MHILL.

  8. Advanced accelerator theory development

    SciTech Connect

    Sampayan, S.E.; Houck, T.L.; Poole, B.; Tishchenko, N.; Vitello, P.A.; Wang, I.

    1998-02-09

    A new accelerator technology, the dielectric wall accelerator (DWA), is potentially an ultra compact accelerator/pulsed power driver. This new accelerator relies on three new components: the ultra-high gradient insulator, the asymmetric Blumlein and low jitter switches. In this report, we focused our attention on the first two components of the DWA system the insulators and the asymmetric Blumlein. First, we sought to develop the necessary design tools to model and scale the behavior of the high gradient insulator. To perform this task we concentrated on modeling the discharge processes (i.e., initiation and creation of the surface discharge). In addition, because these high gradient structures exhibit favorable microwave properties in certain accelerator configurations, we performed experiments and calculations to determine the relevant electromagnetic properties. Second, we performed circuit modeling to understand energy coupling to dynamic loads by the asymmetric Blumlein. Further, we have experimentally observed a non-linear coupling effect in certain asymmetric Blumlein configurations. That is, as these structures are stacked into a complete module, the output voltage does not sum linearly and a lower than expected output voltage results. Although we solved this effect experimentally, we performed calculations to understand this effect more fully to allow better optimization of this DWA pulse-forming line system.

  9. Charge to Road Map Development Sessions

    NASA Technical Reports Server (NTRS)

    Barth, Janet

    2004-01-01

    Develop a road map for new standard Model applications radiation belt models. Model applications: Spacecraft and instruments. Reduce risk. Reduce cost. Improve performance. Increase system lifetime. Reduce risk to astronauts.

  10. Programme Development. Paper Presentations: Session F.

    ERIC Educational Resources Information Center

    2000

    This document contains 35 papers from the program development section of an international conference on vocational education and training (VET) for lifelong learning in the information era. The following are among the papers included: "Using Quality Indicators to Create World-Class Curricula: From Concept to Application" (Curtis Finch, Timo…

  11. Strategies for the Internal Development of Summer Sessions.

    ERIC Educational Resources Information Center

    Seagren, Alan T.; And Others

    Organizational matters and strategies useful in developing more effective collegiate summer sessions are discussed, and examples of some productive strategies at the University of Nebraska-Lincoln are reported. Four elements of organizational structure in higher education considered are organizational environment, mission and goals, governance…

  12. 78 FR 22225 - Meeting: African Development Foundation, Board of Directors Executive Session Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-15

    ...; ] AFRICAN DEVELOPMENT FOUNDATION Board of Directors Executive Session Meeting Meeting: African Development Foundation, Board of Directors Executive Session Meeting Time: Tuesday, April 23, 2013 11:15 a.m. to 2:15...

  13. Accelerated leach test development program

    SciTech Connect

    Fuhrmann, M.; Pietrzak, R.F.; Heiser, J.; Franz, E.M.; Colombo, P.

    1990-11-01

    In FY 1989, a draft accelerated leach test for solidified waste was written. Combined test conditions that accelerate leaching were validated through experimental and modeling efforts. A computer program was developed that calculates test results and models leaching mechanisms. This program allows the user to determine if diffusion controls leaching and, if this is the case, to make projections of releases. Leaching mechanisms other than diffusion (diffusion plus source term partitioning and solubility limited leaching) are included in the program is indicators of other processes that may control leaching. Leach test data are presented and modeling results are discussed for laboratory scale waste forms composed of portland cement containing sodium sulfate salt, portland cement containing incinerator ash, and vinyl ester-styrene containing sodium sulfate. 16 refs., 38 figs., 5 tabs.

  14. Accelerator structure development for NLC

    SciTech Connect

    Hoag, H.A.; Deruyter, H.; Pearson, C.; Ruth, R.D.; Wang, J.W.; Schaefer, J.

    1993-04-01

    In the program of work directed towards the development of an X-Band Next Linear Collider accelerator structure, two different test accelerator sections have been completed, and a third is being fabricated. The first is a simple 30-cell constant-impedance section in which no special attention was given to surface finish, pumping, and alignment. The second is an 86-cell section in which the cells were precision diamond-turned by Texas Instruments Inc. The structure has internal water-cooling and vacuum pumping manifolds. Some design details are given for the third section, which is a 206-cell structure with cavities dimensioned to give a Gaussian distribution of dipole mode frequencies. It has conventional-machining surface finishes and external water and pumping manifolds. Component design, fabrication, and assembly brazing are described for the first two experimental sections.

  15. Embryonic development during chronic acceleration

    NASA Technical Reports Server (NTRS)

    Smith, A. H.; Abbott, U. K.

    1982-01-01

    Experiments carried out on chicken eggs indicate that the embryo is affected during very early development, especially over the first four days, and during hatching. In the first four days, the brain develops as well as the anlage for all other organs. In addition, the heart commences to function and the extraembryonic membranes that compartmentalize the egg contents form. The latter require an appreciable extension and folding of tissue which may be disrupted by the mechanical load. Observations of embryonic abnormalities that occur during chronic acceleration suggest an inhibition of development of the axial skeleton, which is rarely seen otherwise, a general retardation of embryonic growth, and circulatory problems. The final stages of development (after 18 days) involve the uptake of fluids, the transition to aerial respiration, and the reorientation of the embryo into a normal hatching position. At 4 G mortality is very high during this period, with a majority of embryos failing to reorient into the normal hatching position.

  16. UCLA accelerator research & development. Progress report

    SciTech Connect

    1997-09-01

    This report discusses work on advanced accelerators and beam dynamics at ANL, BNL, SLAC, UCLA and Pulse Sciences Incorporated. Discussed in this report are the following concepts: Wakefield acceleration studies; plasma lens research; high gradient rf cavities and beam dynamics studies at the Brookhaven accelerator test facility; rf pulse compression development; and buncher systems for high gradient accelerator and relativistic klystron applications.

  17. UCLA accelerator research and development

    SciTech Connect

    Cline, D.B.

    1992-01-01

    This progress report covers work supported by the above DOE grant over the period November 1, 1991 to July 31, 1992. The work is a program of experimental and theoretical studies in advanced particle accelerator research and development for high energy physics applications. The program features research at particle beam facilities in the United States and includes research on novel high power sources, novel focussing systems (e.g. plasma lens), beam monitors, novel high brightness, high current gun systems, and novel flavor factories in particular the {phi} Factory.

  18. Particle accelerator development: Selected examples

    NASA Astrophysics Data System (ADS)

    Wei, Jie

    2016-03-01

    About 30 years ago, I was among several students mentored by Professor Yang at Stony Brook to enter the field of particle accelerator physics. Since then, I have been fortunate to work on several major accelerator projects in USA and in China, guided and at times directly supported by Professor Yang. The field of accelerator physics is flourishing worldwide both providing indispensable tools for fundamental physics research and covering an increasingly wide spectrum of applications beneficial to our society.

  19. Particle Accelerator Development: Selected Examples

    NASA Astrophysics Data System (ADS)

    Wei, Jie

    About 30 years ago, I was among several students mentored by Professor Yang at Stony Brook to enter the field of particle accelerator physics. Since then, I have been fortunate to work on several major accelerator projects in USA and in China, guided and at times directly supported by Professor Yang. The field of accelerator physics is flourishing worldwide both providing indispensable tools for fundamental physics research and covering an increasingly wide spectrum of applications beneficial to our society.

  20. Session: What can we learn from developed wind resource areas

    SciTech Connect

    Thelander, Carl; Erickson, Wally

    2004-09-01

    This session at the Wind Energy and Birds/Bats workshop was composed of two parts intended to examine what existing science tells us about wind turbine impacts at existing wind project sites. Part one dealt with the Altamont Wind Resource area, one of the older wind projects in the US, with a paper presented by Carl Thelander titled ''Bird Fatalities in the Altamont Pass Wind Resource Area: A Case Study, Part 1''. Questions addressed by the presenter included: how is avian habitat affected at Altamont and do birds avoid turbine sites; are birds being attracted to turbine strings; what factors contribute to direct impacts on birds by wind turbines at Altamont; how do use, behavior, avoidance and other factors affect risk to avian species, and particularly impacts those species listed as threatened, endangered, or of conservation concern, and other state listed species. The second part dealt with direct impacts to birds at new generation wind plants outside of California, examining such is sues as mortality, avoidance, direct habitat impacts from terrestrial wind projects, species and numbers killed per turbine rates/MW generated, impacts to listed threatened and endangered species, to USFWS Birds of Conservation Concern, and to state listed species. This session focused on newer wind project sites with a paper titled ''Bird Fatality and Risk at New Generation Wind Projects'' by Wally Erickson. Each paper was followed by a discussion/question and answer period.

  1. Summary session B : more observations at existing accelerators and concerns for future machines.

    SciTech Connect

    Harkay, K.; Accelerator Systems Division

    2004-01-01

    Beginning with the International Workshop on Multibunch Instabilities in Tsukuba (KEK, 1997) [1], and continuing with special Electron Cloud workshops in Santa Fe (LANL/ANL, 2000) [2], Tsukuba (KEK, 2001) [3], Geneva (CERN, 2002) [4] and the present workshop, it is remarkable that new observations of electron cloud effects continue to be reported, spreading from proton rings to positron and electron rings to heavy-ion linacs and rings. This paper summarizes a rich collection of recent observations, as well as issues for future machines, presented in Session B. An attempt is also made to summarize conclusions and questions raised by the presenters. Efforts at several proton, positron, electron (colliders), and ion rings and linacs continue to characterize and finetune our understanding of electron cloud effects and the generation and suppression of electron clouds. An incomplete outline of the topics presented and related machines follows: (1) EC suppression - (a) Scrubbing (SPS, RHIC); (b) Solenoid (PEPII, KEKB, KEK-PS, RHIC, PSR); (c) TiN, NEG (PEPII, PSR, RHIC, SPS, others); and (d) EC Collectors (HCX, KEK-PS); (2) EC vs. pressure (RHIC, SPS, KEKB, PEPII); (3) Bunch length effect (SPS, RHIC); (4) Memory effect and EC lifetime (PSR, KEKB, KEKPS, SPS); and (5) New EC diagnostics - (a) RFA in quads (SPS, PSR (planned)); (b) EC sweeper (PSR, KEK-PS); (c) HCX GESD: electron and gas emission rates; (d) Microwave TE (more work needed). Significant progress has been made in identifying and quantifying those surface parameters most critical in the accurate prediction of electron cloud effects. A strong focus of experimental efforts is in benchmarking analytical and numerical modeling with measured data, and some consistency is emerging, although work remains to be done.

  2. Induction accelerator development for heavy ion fusion

    SciTech Connect

    Reginato, L.L.

    1993-05-01

    For approximately a decade, the Heavy Ion Fusion Accelerator Research (HIFAR) group at LBL has been exploring the use of induction accelerators with multiple beams as the driver for inertial fusion targets. Scaled experiments have investigated the transport of space charge dominated beams (SBTE), and the current amplification and transverse emittance control in induction linacs (MBE-4) with very encouraging results. In order to study many of the beam manipulations required by a driver and to further develop economically competitive technology, a proposal has been made in partnership with LLNL to build a 10 MeV accelerator and to conduct a series of experiments collectively called the Induction Linac System Experiments (ILSE). The major components critical to the ILSE accelerator are currently under development. We have constructed a full scale induction module and we have tested a number of amorphous magnetic materials developed by Allied Signal to establish an overall optimal design. The electric and magnetic quadrupoles critical to the transport and focusing of heavy ion beams are also under development The hardware is intended to be economically competitive for a driver without sacrificing any of the physics or performance requirements. This paper will concentrate on the recent developments and tests of the major components required by the ILSE accelerator.

  3. The Knowledge Accelerating the Society Development

    NASA Astrophysics Data System (ADS)

    Šmíd, Jaroslav; Sakál, Peter

    2010-01-01

    The formation of appropriate conditions can accelerate the society development. According to the existing definitions, the society can be viewed as mankind as a whole, or a state, a region or a group of businessmen. This paper extends and supplements of the contribution [1]. It deals with the knowledge accelerating the society development using the modified formal notation of the society development according to [2]. The open innovation concept [3] presents the intentional use of external knowledge flow. This paper deals with the intentional use of knowledge in time.

  4. Accelerated Leadership Development: Fast Tracking School Leaders

    ERIC Educational Resources Information Center

    Earley, Peter; Jones, Jeff

    2010-01-01

    "Accelerated Leadership Development" captures and communicates the lessons learned from successful fast-track leadership programmes in the private and public sector, and provides a model which schools can follow and customize as they plan their own leadership development strategies. As large numbers of headteachers and other senior staff retire,…

  5. Advanced Microgravity Acceleration Measurement Systems Being Developed

    NASA Technical Reports Server (NTRS)

    Sicker, Ronald J.; Kacpura, Thomas J.

    2002-01-01

    The Advanced Microgravity Acceleration Measurement Systems (AMAMS) project at the NASA Glenn Research Center is part of the Instrument Technology Development program to develop advanced sensor systems. The primary focus of the AMAMS project is to develop microelectromechanical (MEMS) acceleration sensor systems to replace existing electromechanical-sensor-based systems presently used to assess relative gravity levels aboard spacecraft. These systems are used in characterizing both vehicle and payload responses to low-gravity vibroacoustic environments. The collection of microgravity acceleration data has cross-disciplinary utility to the microgravity life and physical sciences and the structural dynamics communities. The inherent advantages of semiconductor-based systems are reduced size, mass, and power consumption, while providing enhanced stability.

  6. Acceleration in dental development: fact or fiction.

    PubMed

    Holtgrave, E A; Kretschmer, R; Müller, R

    1997-12-01

    The aim of this investigation was to determine whether an actual acceleration in dental development has taken place over the last 30 years in a European population group, as is so readily observable in relation to body height. In this study, radiographs of 1038 healthy European children, 516 boys and 522 girls, were evaluated. The methodology and norms given by Nolla (1960) for both sexes were used and compared with the tooth developmental stages in our subjects. In girls, no difference to Nolla's norms could be detected. However, in boys, dental development has accelerated. This difference was most apparent in the 3- to 9-year-old age group and was statistically significant. Thus, over the last 30 years, a small acceleration in dental development has taken place in very young males. PMID:9458603

  7. Vehicle Systems Integration Laboratory Accelerates Powertrain Development

    SciTech Connect

    2014-04-15

    ORNL's Vehicle Systems Integration (VSI) Laboratory accelerates the pace of powertrain development by performing prototype research and characterization of advanced systems and hardware components. The VSI Lab is capable of accommodating a range of platforms from advanced light-duty vehicles to hybridized Class 8 powertrains with the goals of improving overall system efficiency and reducing emissions.

  8. Vehicle Systems Integration Laboratory Accelerates Powertrain Development

    ScienceCinema

    None

    2014-06-25

    ORNL's Vehicle Systems Integration (VSI) Laboratory accelerates the pace of powertrain development by performing prototype research and characterization of advanced systems and hardware components. The VSI Lab is capable of accommodating a range of platforms from advanced light-duty vehicles to hybridized Class 8 powertrains with the goals of improving overall system efficiency and reducing emissions.

  9. Management Development. [Concurrent Symposium Session at AHRD Annual Conference, 1998.

    ERIC Educational Resources Information Center

    1998

    This document contains four papers from a symposium on management development. "The Effect of Supervisor/Subordinate Relationship on Subordinate Performance, Role Ambiguity and Conflict, and Job Satisfaction" (Michael J. Nocera, Judith A. Kolb) finds that a strong perceived relationship with supervisors was negatively correlated with role…

  10. Human Resource Development and Manpower Training. Paper Presentations: Session B.

    ERIC Educational Resources Information Center

    2000

    This document contains 18 papers from the human resource development and manpower training section of an international conference on vocational education and training (VET) for lifelong learning in the information era. The following papers are included: "Use of Social and Economic Modeling to Plan Vocational Education and Training" (David L.…

  11. Alternative energy sources session ocean thermal energy conversion: Technology development

    NASA Astrophysics Data System (ADS)

    Richards, W. E.; Vadus, J. R.

    1980-03-01

    Four ocean-energy technologies with significant promise are explored: ocean thermal energy conversion; wave power; ocean currents; and salinity gradients. The major funding emphasis has been in OTEC. Technical developments, accomplishments and major findings, remaining problems, and proposed plans for the future are discussed.

  12. Sessional Academic Success: A Distributed Framework for Academic Support and Development

    ERIC Educational Resources Information Center

    Hamilton, Jillian; Fox, Michelle; McEwan, Mitchell

    2013-01-01

    With approximately half of Australian university teaching now performed by Sessional Academics, there has been growing recognition of the contribution they make to student learning. At the same time, sector-wide research and institutional audits continue to raise concerns about academic development, quality assurance, recognition and belonging…

  13. Developments in State Regulatory Reform. The Experience in Nebraska. Plenary [Session].

    ERIC Educational Resources Information Center

    Dibbern, Chris

    This paper presented during the plenary session of the 1989 Telecommunications Policy Research Conference discusses developments in regulatory reform in Nebraska. A review of the current state of the Nebraska telecommunications regulatory environment is followed by a discussion of the deregulation bill (LB 835) and the latest Nebraska Supreme…

  14. Guidelines for Developing an Academic Acceleration Policy

    ERIC Educational Resources Information Center

    Colangelo, Nicholas; Assouline, Susan G.; Marron, Maureen A.; Castellano, Jaime A.; Clinkenbeard, Pamela R.; Rogers, Karen; Calvert, Eric; Malek, Rosanne; Smith, Donnajo

    2010-01-01

    As an educational intervention, acceleration is decidedly effective for high-ability students. The research support for acceleration that has accumulated over many decades is robust and consistent and allows us to confidently state that carefully planned acceleration decisions are successful. Both grade-based and content-based acceleration are…

  15. Session: Development and application of guidelines for siting, constructing, operating and monitoring wind turbines

    SciTech Connect

    Manville, Albert; Hueckel, Greg

    2004-09-01

    This session at the Wind Energy and Birds/Bats workshop consisted of two presentations followed by a discussion/question and answer period. The two papers were: 'Development and Application of USFWS Guidance for Site Evaluation, Siting, Construction, Operation and Monitoring of Wind Turbines' by Albert Manville and 'Wind Power in Washington State' by Greg Hueckel. The session provided a comparison of wind project guidelines developed by the U.S. Fish and Wildlife Service (USFWS) in May 2003 and the Washington State Department of Fish and Wildlife in August 2003. Questions addressed included: is there a need or desire for uniform national or state criteria; can other states learn from Washington State's example, or from the USFWS voluntary guidelines; should there be uniform requirements/guidelines/check-lists for the siting, operation, monitoring, and mitigation to prevent or minimize avian, bat, and other wildlife impacts.

  16. Development and Validation of the Documentation of Occupational Therapy Session during Intervention (D.O.T.S.I.)

    ERIC Educational Resources Information Center

    Bart, O.; Avrech Bar, M.; Rosenberg, L.; Hamudot, V.; Jarus, T.

    2011-01-01

    Objective: To develop and validate a form for Documentation of Occupational Therapy Session during Intervention (D.O.T.S.I) based on the OTPF. This form may fill the need for more consistent and detailed documentation of the intervention process. Method: Fifty five pediatric OT's documented 2-3 treatment sessions. A total of 120 treatment sessions…

  17. Accelerator System Development at High Voltage Engineering

    SciTech Connect

    Klein, M. G.; Gottdang, A.; Haitsma, R. G.; Mous, D. J. W.

    2009-03-10

    Throughout the years, HVE has continuously extended the capabilities of its accelerator systems to meet the rising demands from a diverse field of applications, among which are deep level ion implantation, micro-machining, neutron production for biomedical research, isotope production or accelerator mass spectrometry. Characteristic for HVE accelerators is the coaxial construction of the all solid state power supply around the acceleration tubes. With the use of solid state technology, the accelerators feature high stability and very low ripple. Terminal voltages range from 1 to 6 MV for HVE Singletrons and Tandetrons. The high-current versions of these accelerators can provide ion beams with powers of several kW. In the last years, several systems have been built with terminal voltages of 1.25 MV, 2 MV and 5 MV. Recently, the first system based on a 6 MV Tandetron has passed the factory tests. In this paper we describe the characteristics of the HVE accelerator systems and present as example recent systems.

  18. Preface: Special Session SpS11 Strategic Plan and the Global Office of Astronomy for Development

    NASA Astrophysics Data System (ADS)

    Montmerle, Thierry

    2015-03-01

    The purpose of this Special Session 11 was to bring together the many individuals from around the world who are active in realising the spirit of the IAU strategic plan. Appropriately entitled IAU Strategic Plan and the Global Office of Astronomy for Development, this special session invited contributions relating to: (i) IAU Strategic Plan, (ii) The IAU Global Office of Astronomy for Development, (iii) Regional nodes for ``Astronomy for Development'' activities, (iv) Sector Task Forces, and (v) Volunteers and volunteer opportunities.

  19. Technologies using accelerator-driven targets under development at BNL

    SciTech Connect

    Van Tuyle, G.J.

    1994-08-01

    Recent development work conducted at Brookhaven National Laboratory on technologies which use particle accelerator-driven targets is summarized. These efforts include development of the Spallation-Induced Lithium Conversion (SILC) Target for the Accelerator Production of Tritium (APT), the Accelerator-Driven Assembly for Plutonium Transformation (ADAPT) Target for the Accelerator-Based Conversion (ABC) of excess weapons plutonium. The PHOENIX Concept for the accelerator-driven transmutation of minor actinides and fission products from the waste stream of commercial nuclear power plants, and other potential applications.

  20. Kif14 overexpression accelerates murine retinoblastoma development.

    PubMed

    O'Hare, Michael; Shadmand, Mehdi; Sulaiman, Rania S; Sishtla, Kamakshi; Sakisaka, Toshiaki; Corson, Timothy W

    2016-10-15

    The mitotic kinesin KIF14 has an essential role in the recruitment of proteins required for the final stages of cytokinesis. Genomic gain and/or overexpression of KIF14 has been documented in retinoblastoma and a number of other cancers, such as breast, lung and ovarian carcinomas, strongly suggesting its role as an oncogene. Despite evidence of oncogenic properties in vitro and in xenografts, Kif14's role in tumor progression has not previously been studied in a transgenic cancer model. Using a novel Kif14 overexpressing, simian virus 40 large T-antigen retinoblastoma (TAg-RB) double transgenic mouse model, we aimed to determine Kif14's role in promoting retinal tumor formation. Tumor initiation and development in double transgenics and control TAg-RB littermates were documented in vivo over a time course by optical coherence tomography, with subsequent ex vivo quantification of tumor burden. Kif14 overexpression led to an accelerated initiation of tumor formation in the TAg-RB model and a significantly decreased tumor doubling time (1.8 vs. 2.9 weeks). Moreover, overall percentage tumor burden was also increased by Kif14 overexpression. These data provide the first evidence that Kif14 can promote tumor formation in susceptible cells in vivo. PMID:27270502

  1. Accelerated Application Development: The ORNL Titan Experience

    SciTech Connect

    Joubert, Wayne; Archibald, Richard K.; Berrill, Mark A.; Brown, W. Michael; Eisenbach, Markus; Grout, Ray; Larkin, Jeff; Levesque, John; Messer, Bronson; Norman, Matthew R.; Philip, Bobby; Sankaran, Ramanan; Tharrington, Arnold N.; Turner, John A.

    2015-05-09

    The use of computational accelerators such as NVIDIA GPUs and Intel Xeon Phi processors is now widespread in the high performance computing community, with many applications delivering impressive performance gains. However, programming these systems for high performance, performance portability and software maintainability has been a challenge. In this paper we discuss experiences porting applications to the Titan system. Titan, which began planning in 2009 and was deployed for general use in 2013, was the first multi-petaflop system based on accelerator hardware. To ready applications for accelerated computing, a preparedness effort was undertaken prior to delivery of Titan. In this paper we report experiences and lessons learned from this process and describe how users are currently making use of computational accelerators on Titan.

  2. Accelerated Application Development: The ORNL Titan Experience

    DOE PAGESBeta

    Joubert, Wayne; Archibald, Richard K.; Berrill, Mark A.; Brown, W. Michael; Eisenbach, Markus; Grout, Ray; Larkin, Jeff; Levesque, John; Messer, Bronson; Norman, Matthew R.; et al

    2015-05-09

    The use of computational accelerators such as NVIDIA GPUs and Intel Xeon Phi processors is now widespread in the high performance computing community, with many applications delivering impressive performance gains. However, programming these systems for high performance, performance portability and software maintainability has been a challenge. In this paper we discuss experiences porting applications to the Titan system. Titan, which began planning in 2009 and was deployed for general use in 2013, was the first multi-petaflop system based on accelerator hardware. To ready applications for accelerated computing, a preparedness effort was undertaken prior to delivery of Titan. In this papermore » we report experiences and lessons learned from this process and describe how users are currently making use of computational accelerators on Titan.« less

  3. Creating psychological connections between intervention recipients: development and focus group evaluation of a group singing session for people with aphasia

    PubMed Central

    Tarrant, Mark; Warmoth, Krystal; Code, Chris; Dean, Sarah; Goodwin, Victoria A; Stein, Ken; Sugavanam, Thavapriya

    2016-01-01

    Objectives The study sought to identify key design features that could be used to create a new framework for group-based health interventions. We designed and tested the first session of a group intervention for stroke survivors with aphasia which was aimed at nurturing new psychological connections between group members. Setting The intervention session, a participant focus group and interviews with intervention facilitators were held in a local community music centre in the South West of England. Participants A convenience sample of 10 community-dwelling people with poststroke aphasia participated in the session. Severity of aphasia was not considered for inclusion. Intervention Participants took part in a 90-min group singing session which involved singing songs from a specially prepared song book. Musical accompaniment was provided by the facilitators. Primary and secondary outcome measures Participants and group facilitators reported their experiences of participating in the session, with a focus on activities within the session related to the intervention aims. Researcher observations of the session were also made. Results Two themes emerged from the analysis, concerning experiences of the session (‘developing a sense of group belonging’) and perceptions of its design and delivery (‘creating the conditions for engagement’). Participants described an emerging sense of shared social identity as a member of the intervention group and identified fixed (eg, group size, session breaks) and flexible (eg, facilitator responsiveness) features of the session which contributed to this emergence. Facilitator interviews and researcher observations corroborated and expanded participant reports. Conclusions Engagement with health intervention content may be enhanced in group settings when intervention participants begin to establish positive and meaningful psychological connections with other group members. Understanding and actively nurturing these connections

  4. High charge short electron bunches for wakefield accelerator structures development.

    SciTech Connect

    Conde, M. E.

    1998-09-25

    The Argonne Wakefield Accelerator group develops accelerating structures based on dielectric loaded waveguides. We use high charge short electron bunches to excite wakefields in dielectric loaded structures, and a second (low charge) beam to probe the wakefields left behind by the drive beam. We report measurements of beam parameters and also initial results of the dielectric loaded accelerating structures. We have studied acceleration of the probe beam in these structures and we have also made measurements on the RF pulses that are generated by the drive beam. Single drive bunches, as well as multiple bunches separated by an integer number of RF periods have been used to generate the accelerating wakefields.

  5. Accelerator development for a radioactive beam facility based on ATLAS.

    SciTech Connect

    Shepard, K. W.

    1998-01-08

    The existing superconducting linac ATLAS is in many respects an ideal secondary beam accelerator for an ISOL (Isotope separator on-line) type radioactive beam facility. Such a facility would require the addition of two major accelerator elements: a low charge state injector for the existing heavy ion linac, and a primary beam accelerator providing 220 MV of acceleration for protons and light ions. Development work for both of these elements, including the option of superconducting cavities for the primary beam accelerator is discussed.

  6. Poster Session

    NASA Technical Reports Server (NTRS)

    1997-01-01

    In this session, Poster Session, the discussion focuses on the following topics: Development of correlative measures for the assessment of attention and memory; Biodynamical Responses of the Crewmember Head/Neck System During Emergence Ejection; Fecundation in the Sky, a Ten Years Old Experiment in Microgravity; A Modified Botex Incubator as a Transport System For Developing Crickets into Space; Chromosomal Aberrations in Peripheral Lymphocytes of Cosmonauts and Astronauts after Space Flights; Method for Establishing Long term Bone Marrow; Cultures Under Microgravity Conditions Reproduction Under Simulated Weightlessness --Mammalian in vivo Experiments Under Suspension; Towards Human Movement Analysis Without the Use of Markers; Habitability Requirements For a Cogent Mars Mission; The Saucer Concept for Space Habitats; New Way In Modeling the Growth of the Organism; The Fractionation of Hydrogen and Oxygen Stable Isotopes By Life Support Systems of Space Station "MIR"; and Effect of Space Flight on Neutrophil Function.

  7. Technology development for high power induction accelerators

    SciTech Connect

    Birx, D.L.; Reginato, L.L.

    1985-06-11

    The marriage of Induction Linac technology with Nonlinear Magnetic Modulators has produced some unique capabilities. It appears possible to produce electron beams with average currents measured in amperes, at gradients exceeding 1 MeV/meter, and with power efficiencies approaching 50%. A 2 MeV, 5 kA electron accelerator has been constructed at the Lawrence Livermore National Laboratory (LLNL) to demonstrate these concepts and to provide a test facility for high brightness sources. The pulse drive for the accelerator is based on state-of-the-art magnetic pulse compressors with very high peak power capability, repetition rates exceeding a kilohertz and excellent reliability.

  8. Vacuum Insulator Development for the Dielectric Wall Accelerator

    SciTech Connect

    Harris, J R; Blackfield, D; Caporaso, G J; Chen, Y; Hawkins, S; Kendig, M; Poole, B; Sanders, D M; Krogh, M; Managan, J E

    2008-03-17

    At Lawrence Livermore National Laboratory, we are developing a new type of accelerator, known as a Dielectric Wall Accelerator, in which compact pulse forming lines directly apply an accelerating field to the beam through an insulating vacuum boundary. The electrical strength of this insulator may define the maximum gradient achievable in these machines. To increase the system gradient, we are using 'High Gradient Insulators' composed of alternating layers of dielectric and metal for the vacuum insulator. In this paper, we present our recent results from experiment and simulation, including the first test of a High Gradient Insulator in a functioning Dielectric Wall Accelerator cell.

  9. Arrayed Diagnostic Development on the HyperV Plasma Accelerators

    NASA Astrophysics Data System (ADS)

    Brockington, Samuel; Case, Andrew; Messer, Sarah; Bomgardner, Richard; Witherspoon, F. D.

    2008-11-01

    The sparkgap injected plasma accelerator is one of several coaxial railguns constructed at HyperV to accelerate dense plasmas to high velocities. A circumferential array of 112 high voltage tungsten electrodes ablates polyethylene to form and inject a toroidally shaped plasma into the annular breech at the rear of the accelerator. A pulse forming network then applies several hundred kiloamps to the coaxial electrodes to accelerate the plasma. A 4-chord laser deflectometer and a 32-sensor fast photodiode array are being developed to help resolve the structure, density, and velocity of the accelerated plasma jet for different accelerator parameters. We present details of the diagnostic designs and initial data. Work supported by the U.S. DOE Office of Fusion Energy Sciences.

  10. Development of a dedicated superconducting accelerator for positron production

    NASA Astrophysics Data System (ADS)

    O'Rourke, B. E.; Oshima, N.; Kuroda, R.; Suzuki, R.; Ohdaira, T.; Kinomura, A.; Hayashizaki, N.; Minehara, E.; Yamauchi, H.; Fukamizu, Y.; Shikibu, M.; Kawamoto, T.; Minehara, Y.

    2011-01-01

    We report on the current status of a project to develop a dedicated superconducting accelerator for slow positron production at AIST. Two 500 MHz, 5 cell cavities will form the basis of the new accelerator. Initial set-up and preliminary design activities are reported.

  11. Learning Disabilities in the Workplace: A Professional Development Packet. Session 1 & 2.

    ERIC Educational Resources Information Center

    Corley, Mary Ann; Tibbetts, John

    This field-tested training packet, which was designed for adult literacy providers, contains preparation materials, facilitator's notes, handout masters, and transparency masters for two 3-hour sessions on learning disabilities (LD) in the workplace. (At the end of the first session supported by the packet, participants will be able to do the…

  12. Advanced Microgravity Acceleration Measurement Systems (AMAMS) Being Developed

    NASA Technical Reports Server (NTRS)

    Sicker, Ronald J.; Kacpura, Thomas J.

    2003-01-01

    The Advanced Microgravity Acceleration Measurement Systems (AMAMS) project is part of NASA s Instrument Technology Development program to develop advanced sensor systems. The primary focus of the AMAMS project is to develop microelectromechanical systems (MEMS) for acceleration sensor systems to replace existing electromechanical sensor systems presently used to assess relative gravity levels aboard spacecraft. These systems are used to characterize both vehicle and payload responses to low-gravity vibroacoustic environments. The collection of microgravity acceleration data is useful to the microgravity life sciences, microgravity physical sciences, and structural dynamics communities. The inherent advantages of semiconductor-based systems are reduced size, mass, and power consumption, with enhanced long-term calibration stability.

  13. Development of compact linear accelerator in KBSI

    SciTech Connect

    Yoon, Jang-Hee; Lee, Byoung-Seob; Choi, Seyong; Park, Jin Yong; Ok, Jung-Woo; Won, Mi-Sook

    2012-02-15

    The compact linear accelerator using a 28 GHz ECRIS is under construction in KBSI, South Korea. The main capability of this facility is the production of fast neurons for the neutron radiography. The designing of a superconducting magnet, microwave transmission system, beam extraction, and plasma chamber of ECRIS were finished. The nominal axial design fields of the magnets are 3.6 T at injection and 2.2 T at extraction; the nominal radial design field strength at the plasma chamber wall is 2.1 T. We already installed 10 kW, 28 GHz gyrotron, and tested a microwave power from gyrotron using a dummy load. The current status will be discussed in this paper.

  14. Development of compact linear accelerator in KBSI.

    PubMed

    Yoon, Jang-Hee; Lee, Byoung-Seob; Choi, Seyong; Park, Jin Yong; Ok, Jung-Woo; Won, Mi-Sook

    2012-02-01

    The compact linear accelerator using a 28 GHz ECRIS is under construction in KBSI, South Korea. The main capability of this facility is the production of fast neurons for the neutron radiography. The designing of a superconducting magnet, microwave transmission system, beam extraction, and plasma chamber of ECRIS were finished. The nominal axial design fields of the magnets are 3.6 T at injection and 2.2 T at extraction; the nominal radial design field strength at the plasma chamber wall is 2.1 T. We already installed 10 kW, 28 GHz gyrotron, and tested a microwave power from gyrotron using a dummy load. The current status will be discussed in this paper. PMID:22380162

  15. IFLA General Conference, 1986. Pre-Session Seminar on Special Libraries and Their Role in National Development. Papers.

    ERIC Educational Resources Information Center

    International Federation of Library Associations and Institutions, The Hague (Netherlands).

    A seminar on special libraries and their role in national development was held as a pre-session before the IFLA conference in 1986. Papers presented include: (1) "On the Problem of Document Delivery in the Field of Science and Technology in Asia" (Daxun He, People's Republic of China); (2) "The Planning and Development of Special Library and…

  16. Session: Bat ecology related to wind development and lessons learned about impacts on bats from wind development

    SciTech Connect

    Johnson, Greg; Kunz, Thomas

    2004-09-01

    This session at the Wind Energy and Birds/Bats workshop consisted of two paper presentations followed by a discussion/question and answer period. It was the first of the sessions to shift the focus to the issue of wind energy development's impacts specifically to bats. The presentations discussed lessons that have been learned regarding direct and indirect impacts on bats and strategies planned to address such issues. Presenters addressed what the existing science demonstrates about land-based wind turbine impacts on bats, including: mortality, avoidance, direct habitat impacts, species and numbers killed, per turbine rates/per MW generated, and impacts on threatened and endangered species. They discussed whether there is sufficient data for wind turbines and bat impacts for projects in the eastern US, especially on ridge tops. Finally, the subject of offshore impacts on bats was briefly addressed, including what lessons have been learned in Europe and how these can be applied in the U S. Paper one, by Greg Johnson, was titled ''A Review of Bat Impacts at Wind Farms in the US''. Paper two, by Thomas Kunz, was titled ''Wind Power: Bats and Wind Turbines''.

  17. 76 FR 33305 - Medicare Program; Accelerated Development Sessions for Accountable Care Organizations-June 20, 21...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-08

    .... Background In FR Doc. 2011-12342 of May 19, 2011 (76 FR 28988), there were a number of technical errors that... technical and typographical errors in the May 19, 2011 notice (76 FR 28988 and 28989) which include the... central daylight time. III. Correction of Errors In FR Doc. 2011-12342 of May 19, 2011 (76 FR 28988),...

  18. 76 FR 66931 - Medicare Program; Accountable Care Organization Accelerated Development Learning Sessions; Center...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-28

    ... improve the capabilities of provider organizations to coordinate the care of a population of Medicare... improve beneficiaries' quality outcomes and reduce the growth of Medicare expenditures. Completion of the... to build capacity needed to achieve better care for individuals, better population health, and...

  19. 76 FR 50224 - Medicare Program; Accountable Care Organization Accelerated Development Learning Sessions; Center...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-12

    ... Federal Register (76 FR 28988). Each participating team should consist of two to four senior-level leaders... the opportunity to learn about core functions of an ACO and ways to build their organization's... at https://acoregister.rti.org/ . Click on ``contact us'' to send questions or comments via...

  20. Enhancing Tutorial Learning Experiences: A Programme to Develop Sessional-Tutor Teaching Skills by Raising Awareness about Learning

    ERIC Educational Resources Information Center

    Truuvert, Toomas

    2014-01-01

    This article outlines the trial of a programme to enhance tutorial learning experiences by raising sessional-tutor awareness about learning, and reflects on its results. The author developed the programme for an introductory undergraduate unit in finance with historically very large enrolments, diverse student populations, and high failure rates.…

  1. Computational Tools for Accelerating Carbon Capture Process Development

    SciTech Connect

    Miller, David; Sahinidis, N V; Cozad, A; Lee, A; Kim, H; Morinelly, J; Eslick, J; Yuan, Z

    2013-06-04

    This presentation reports development of advanced computational tools to accelerate next generation technology development. These tools are to develop an optimized process using rigorous models. They include: Process Models; Simulation-Based Optimization; Optimized Process; Uncertainty Quantification; Algebraic Surrogate Models; and Superstructure Optimization (Determine Configuration).

  2. Research and development of capacitive transducer with linear acceleration

    NASA Astrophysics Data System (ADS)

    Korobova, Natalia; Kochurina, Elena; Timoshenkov, Sergey; Chaplygin, Yuriy; Anchutin, Stepan; Kosolapov, Andrey

    2015-05-01

    Paper presents the study results and modeling of functional characteristics of the linear acceleration transducers, enabling sensors creation with the specified parameters. Sensing element made for linear acceleration transducer with torsion cruciform section has been proposed on the based design and technological principles. It allows minimizing the impact of cross-acceleration and gives the maximum of center mass displacement for high sensors sensitivity in the given dimensions. The range of measured acceleration from ± 0.2g to ± 50g was provided by changing the torsion bar thickness n = 34 ÷ 56 microns. The transducers frequency range of linear acceleration 100-150 Hz depends on the gas pressure P = 700-800Pa in which the sensor element was located. Methods converting displacement of sensing element in the sensor output have been provided. On their basis the linear acceleration transducers with analog output signal having a predetermined frequency range and high linearity of the transformation (nonlinearity 0.2-1.5%) was developed. Also the linear acceleration transducers with digital signal consuming little (no more than 850 μA), low noisy (standard deviation to 0.1mg/rt-Hz) and high sensitivity (up to 0.1mg) to the accelerations was made. Errors in manufacturing process of sensitive elements and operating environment temperature affect the changes in the characteristics of the linear acceleration transducers. It has been established that different plate thickness up to 3.6% leads to the scale factor error to 4.7%. Irreproducibility of depth anisotropic etching of silicon up to 6.6% introduces an error in the output signal of 2.9 ... 13.8mg.

  3. Computational Tools to Accelerate Commercial Development

    SciTech Connect

    Miller, David C

    2013-01-01

    The goals of the work reported are: to develop new computational tools and models to enable industry to more rapidly develop and deploy new advanced energy technologies; to demonstrate the capabilities of the CCSI Toolset on non-proprietary case studies; and to deploy the CCSI Toolset to industry. Challenges of simulating carbon capture (and other) processes include: dealing with multiple scales (particle, device, and whole process scales); integration across scales; verification, validation, and uncertainty; and decision support. The tools cover: risk analysis and decision making; validated, high-fidelity CFD; high-resolution filtered sub-models; process design and optimization tools; advanced process control and dynamics; process models; basic data sub-models; and cross-cutting integration tools.

  4. Status of high temperature superconductor development for accelerator magnets

    NASA Technical Reports Server (NTRS)

    Hirabayashi, H.

    1995-01-01

    High temperature superconductors are still under development for various applications. As far as conductors for magnets are concerned, the development has just been started. Small coils wound by silver sheathed Bi-2212 and Bi-2223 oxide conductors have been reported by a few authors. Essential properties of high T(sub c) superconductors like pinning force, coherent length, intergrain coupling, weak link, thermal property, AC loss and mechanical strength are still not sufficiently understandable. In this talk, a review is given with comparison between the present achievement and the final requirement for high T(sub c) superconductors, which could be particularly used in accelerator magnets. Discussions on how to develop high T(sub c) superconductors for accelerator magnets are included with key parameters of essential properties. A proposal of how to make a prototype accelerator magnet with high T(sub c) superconductors with prospect for future development is also given.

  5. Nb3Sn accelerator magnet development around the world

    SciTech Connect

    Michael J. Lamm

    2003-06-23

    During the past 30 years superconducting magnet systems have enabled accelerators to achieve energies and luminosities that would have been impractical if not impossible with resistive magnets. By far, NbTi has been the preferred conductor for this application because of its ductility and insensitivity of Jc to mechanical strain. This is despite the fact that Nb{sub 3}Sn has a more favorable Jc vs. B dependence and can operate at much higher temperatures. Unfortunately, NbTi conductor is reaching the limit of it usefulness for high field applications. Despite incremental increases in Jc and operation at superfluid temperatures, magnets are limited to approximately a 10 T field. Improvements in conductor performance combined with future requirements for accelerator magnets to have bore fields greater than 10 T or operate in areas of large beam-induced heat loads now make Nb{sub 3}Sn look attractive. Thus, laboratories in several countries are actively engaged in programs to develop Nb{sub 3}Sn accelerator magnets for future accelerator applications. A summary of this important research activity is presented along with a brief history of Nb{sub 3}Sn accelerator magnet development and a discussion of requirements for future accelerator magnets.

  6. Accelerated larvae development of Ascaris lumbricoides eggs with ultraviolet radiation

    NASA Astrophysics Data System (ADS)

    Aladawi, M. A.; Albarodi, H.; Hammoudeh, A.; Shamma, M.; Sharabi, N.

    2006-01-01

    In order to investigate the effect of UV radiation on the development of Ascaris lumbricoides larvae, eggs were exposed to increasing UV doses. Filtered wastewater from the secondary effluent taken from the Damascus wastewater treatment plant (DWTP) was used as irradiation and incubation medium. The progressive and accelerated embryonation stages were microscopically observed and the percentages of completely developed larvae were determined weekly. Results indicated that the UV radiation accelerated the development of larvae with increasing UV dose. Preliminary information about the relationship between the UV radiation dose and rate of embryonation is also presented.

  7. Space Launch System Accelerated Booster Development Cycle

    NASA Technical Reports Server (NTRS)

    Arockiam, Nicole; Whittecar, William; Edwards, Stephen

    2012-01-01

    With the retirement of the Space Shuttle, NASA is seeking to reinvigorate the national space program and recapture the public s interest in human space exploration by developing missions to the Moon, near-earth asteroids, Lagrange points, Mars, and beyond. The would-be successor to the Space Shuttle, NASA s Constellation Program, planned to take humans back to the Moon by 2020, but due to budgetary constraints was cancelled in 2010 in search of a more "affordable, sustainable, and realistic" concept2. Following a number of studies, the much anticipated Space Launch System (SLS) was unveiled in September of 2011. The SLS core architecture consists of a cryogenic first stage with five Space Shuttle Main Engines (SSMEs), and a cryogenic second stage using a new J-2X engine3. The baseline configuration employs two 5-segment solid rocket boosters to achieve a 70 metric ton payload capability, but a new, more capable booster system will be required to attain the goal of 130 metric tons to orbit. To this end, NASA s Marshall Space Flight Center recently released a NASA Research Announcement (NRA) entitled "Space Launch System (SLS) Advanced Booster Engineering Demonstration and/or Risk Reduction." The increased emphasis on affordability is evident in the language used in the NRA, which is focused on risk reduction "leading to an affordable Advanced Booster that meets the evolved capabilities of SLS" and "enabling competition" to "enhance SLS affordability. The purpose of the work presented in this paper is to perform an independent assessment of the elements that make up an affordable and realistic path forward for the SLS booster system, utilizing advanced design methods and technology evaluation techniques. The goal is to identify elements that will enable a more sustainable development program by exploring the trade space of heavy lift booster systems and focusing on affordability, operability, and reliability at the system and subsystem levels5. For this study

  8. Can hydromorphic conditions accelerate soil development?

    NASA Astrophysics Data System (ADS)

    Ringer, Marianna; Kiss, Klaudia; Horváth-Szabó, Kata; Réka Balázs, Brigitta; Németh, Tibor; Sipos, Péter; Szabó, Máté; Jakab, Gergely; Madarász, Balázs; Szalai, Zoltán

    2016-04-01

    The formation and development of waterlogged (hydromorphic) soils are primarily determined by long-term water saturation. The presence of water in the profile can result increasing speed of soil forming processes including the accumulation of organic matter or other components and mineralogical transformations. Original papers refer more than hundreds of years for this kinds of mineral transformations. We suppose that this process could be more rapid. This study focuses on the mineralogical investigation of a sandy meadow soil (calcic, gleyic Phaeozem ferric, arenic) located in a swampy area in Central Hungary. The starting time of the soil formation is a well documented fact: the parent material deposited during an extremely heavy flood event in the 1960s. Therefore, the studied soil profile is the result of the last half century. Our aim was to explore the degree of mineral phase alteration via soil formation during a half-century under hydromorphic conditions. Routine laboratory measurements (selective dissolution methods for the determination of amorphous and crystalline Fe, and Mn content, X-ray fluorescence spectroscopy measurements for elemental composition determination, X-ray powder diffraction for mineralogical composition, and particle sizing by laser diffraction) were implemented. Morphological and chemical study of carbonate and iron nodules was carried out by electron microprobe. Simple chemical tests (eg. Fe2+ indication by dipiridil test) and morphological observations were performed on the field. Redox potential (Eh) and pH were measured in 20 cm and 40 cm depths by field monitoring station during the vegetation period. Results show that well developed horizons have emerged during fifty years in the studied soil profile. The most intense mineralogical transformations developed in the zone of the heaviest redox oscillation. Soil formation under hydromorphic conditions proceeds at higher speeds contrariwise to the century time scale reported in

  9. An accelerated fusion power development plan

    NASA Astrophysics Data System (ADS)

    Dean, Stephen O.; Baker, Charles C.; Cohn, Daniel R.; Kinkead, Susan D.

    1991-06-01

    Energy for electricity and transportation is a national issue with worldwide environmental and political implications. The world must have energy options for the next century that are not vulnerable to possible disruption for technical, environmental, public confidence, or other reasons. Growing concerns about the greenhouse effect and the safety of transporting oil may lead to reduced burning of coal and other fossil fuels, and the incidents at Three Mile Island and Chernobyl, as well as nuclear waste storage problems, have eroded public acceptance of nuclear fission. Meeting future world energy needs will require improvements in energy efficiency and conservation. However, the world will soon need new central station power plants and increasing amounts of fuel for the transportation sector. The use of fossil fuels, and possibly even fission power, will very likely be restricted because of environmental, safety, and, eventually, supply considerations. Time is running out for policymakers. New energy technologies cannot be brought to the marketplace overnight. Decades are required to bring a new energy production technology from conception to full market penetration. With the added urgency to mitigate deleterious environmental effects of energy use, policymakers must act decisively now to establish and support vigorous energy technology development programs. The U.S. has invested 8 billion over the past 40 years in fusion research and development. If the U.S. fusion program proceeds according to its present strategy, an additional 40 years, and more money, will be expended before fusion will provide commercial electricity. Such an extended schedule is neither cost-effective nor technically necessary. It is time to launch a national venture to construct and operate a fusion power pilot plant. Such a plant could be operational within 15 years of a national commitment to proceed.

  10. Session: Non-fatality and habitat impacts on birds from wind energy development

    SciTech Connect

    Strickland, Dale

    2004-09-01

    This session at the Wind Energy and Birds/Bats workshop was consisted of one paper presentation followed by a discussion/question and answer period. The session focused on discussion of non-collision impacts of wind energy projects on birds, primarily impacts to habitat. The presentation included information about the impacts of habitat fragmentation, disturbance, and site avoidance from wind turbines, as well as from roads, transmission facilities, and other related construction at wind project sites. Whether birds habituate to the presence of turbines and the influence of regional factors were also addressed. The paper given by Dale Strickland was titled ''Overview of Non-Collision Related Impacts from Wind Projects''.

  11. Session: Why avian impacts are a concern in wind energy development

    SciTech Connect

    Winegrad, Gerald

    2004-09-01

    This lunchtime session at the Wind Energy and Birds/Bats workshop consisted of one presentation followed by a discussion/question and answer period. The session provided a more detailed overview of the environmental community's perspective on wind power's impacts on birds. The presentation described how wind projects impact birds, detailing the species distribution of collisions at various sites around the US and discussing problems such as avoidance, habitat disturbance, and cumulative effects on populations. The presentation, ''Wind Turbines and Birds'', was given by Gerald Winegrad from the American Bird Conservancy.

  12. Accelerating Leadership Development via Immersive Learning and Cognitive Apprenticeship

    ERIC Educational Resources Information Center

    Backus, Clark; Keegan, Kevin; Gluck, Charles; Gulick, Lisa M. V.

    2010-01-01

    The authors put forward an approach to leadership development that builds on the principle of accelerated learning. They argue that leadership development, particularly in a period of recession or slow economic growth, needs to deliver results more quickly and with fewer resources. Indeed, they raise the question of whether or not this is what is…

  13. No Time To Kill: Entrainment and Accelerating Courseware Development.

    ERIC Educational Resources Information Center

    Millington, Paula Crnkovich

    This paper examines the concept of time in multimedia, World Wide Web-based courseware development. The biological concept of entrainment (the alignment of rhythms within and between systems) to accelerate courseware development is explored. The discussion begins with the foundational concepts of entrainment from biological systems and social…

  14. Separations technology development to support accelerator-driven transmutation concepts

    SciTech Connect

    Venneri, F.; Arthur, E.; Bowman, C.

    1996-10-01

    This is the final report of a one-year Laboratory-Directed Research and Development (LDRD) Project at the Los Alamos National Laboratory (LANL). This project investigated separations technology development needed for accelerator-driven transmutation technology (ADTT) concepts, particularly those associated with plutonium disposition (accelerator-based conversion, ABC) and high-level radioactive waste transmutation (accelerator transmutation of waste, ATW). Specific focus areas included separations needed for preparation of feeds to ABC and ATW systems, for example from spent reactor fuel sources, those required within an ABC/ATW system for material recycle and recovery of key long-lived radionuclides for further transmutation, and those required for reuse and cleanup of molten fluoride salts. The project also featured beginning experimental development in areas associated with a small molten-salt test loop and exploratory centrifugal separations systems.

  15. Development of wide area environment accelerator operation and diagnostics method

    NASA Astrophysics Data System (ADS)

    Uchiyama, Akito; Furukawa, Kazuro

    2015-08-01

    Remote operation and diagnostic systems for particle accelerators have been developed for beam operation and maintenance in various situations. Even though fully remote experiments are not necessary, the remote diagnosis and maintenance of the accelerator is required. Considering remote-operation operator interfaces (OPIs), the use of standard protocols such as the hypertext transfer protocol (HTTP) is advantageous, because system-dependent protocols are unnecessary between the remote client and the on-site server. Here, we have developed a client system based on WebSocket, which is a new protocol provided by the Internet Engineering Task Force for Web-based systems, as a next-generation Web-based OPI using the Experimental Physics and Industrial Control System Channel Access protocol. As a result of this implementation, WebSocket-based client systems have become available for remote operation. Also, as regards practical application, the remote operation of an accelerator via a wide area network (WAN) faces a number of challenges, e.g., the accelerator has both experimental device and radiation generator characteristics. Any error in remote control system operation could result in an immediate breakdown. Therefore, we propose the implementation of an operator intervention system for remote accelerator diagnostics and support that can obviate any differences between the local control room and remote locations. Here, remote-operation Web-based OPIs, which resolve security issues, are developed.

  16. Mid-infrared Laser System Development for Dielectric Laser Accelerators

    NASA Astrophysics Data System (ADS)

    Jovanovic, Igor; Xu, Guibao; Wandel, Scott

    Laser-driven particle accelerators based on dielectric laser acceleration are under development and exhibit unique and challenging pump requirements. Operation in the mid-infrared (5 μm) range with short pulses (<1 ps FWHM), high pulse energy (>500 μJ) and good beam quality is required. We present our progress on the design and development of a novel two- stage source of mid-infrared pulses for this application, which is based on optical parametric amplification. Beta barium borate and zinc germanium phosphide crystals are used, and are pumped by a Ti:sapphire ultrashort laser and seeded by self-phase modulation and parametric generation-based sources.

  17. Biofuels and Sustainable Development: An Executive Session on the Grand Challenges of the Sustainability Transition

    SciTech Connect

    Lee, Henry; Clark, William C.; Devereaux, Charan

    2008-05-20

    This report is the result of the second in a series of intense workshops and study sessions on Grand Challenges of the Sustainability Transition, organized by the Sustainability Science Program at Harvard University, hosted by Venice International University, and supported by the Italian Ministry of Environment, Land and Sea.

  18. The Constitutional Law Sessions

    ERIC Educational Resources Information Center

    White, Daniel O.

    1972-01-01

    Teachers, attorneys, and law educators met to evaluate 1971 workshops in law education and to plan improved learning experiences at future workshops. Coordination between substantive law sessions and teaching methodology sessions was cited as a major necessity. Teachers were encouraged to develop their own material. (JB)

  19. DEVELOPMENT OF A COMPACT RADIOGRAPHY ACCELERATOR USING DIELECTRIC WALL ACCELERATOR TECHNOLOGY

    SciTech Connect

    Sampayan, S; Caporaso, G; Chen, Y; Hawkins, S; Holmes, C; Krogh, M; McCarrick, J; Nelson, S; Nunnally, W; Poole, B; Rhodes, M; Sanders, D; Selenes, K; Sullivan, J; Wang, L; Watson, J

    2005-06-02

    We are developing an inexpensive compact accelerator system primarily intended for pulsed radiography. Design characteristics are an 8 MeV endpoint energy, 2 kA beam current, a cell gradient of approximately 3 MV/m (for an overall accelerator length is 2-3 m), and <$1/Volt capital costs. Such designs have been made possible with the development of high specific energy dielectrics (>10J/cm{sup 3}), specialized transmission line designs and multi-gap laser triggered low jitter (<1 ns) gas switches. In this geometry, the pulse forming lines, switches, and insulator/beam pipe are fully integrated within each cell to form a compact, stand-alone, stackable unit. We detail our research and modeling to date, recent high voltage test results, and the integration concept of the cells into a radiographic system.

  20. Accelerating Child Survival and Development in Dark Times.

    ERIC Educational Resources Information Center

    Grant, James P.

    Measures were proposed that would enable UNICEF, in association with others and despite prevailing difficult economic circumstances, to more effectively bring well-being and hope to hundreds of millions of children. Specific proposals were designed to help most countries accelerate child survival and development. Most particularly, it was…

  1. Accelerating Early Language Development with Multi-Sensory Training

    ERIC Educational Resources Information Center

    Bjorn, Piia M.; Kakkuri, Irma; Karvonen, Pirkko; Leppanen, Paavo H. T.

    2012-01-01

    This paper reports the outcome of a multi-sensory intervention on infant language skills. A programme titled "Rhyming Game and Exercise Club", which included kinaesthetic-tactile mother-child rhyming games performed in natural joint attention situations, was intended to accelerate Finnish six- to eight-month-old infants' language development. The…

  2. Session: Avian migration and implications for wind power development in the Eastern United States

    SciTech Connect

    Mabey, Sarah; Cooper, Brian

    2004-09-01

    This session at the Wind Energy and Birds/Bats workshop consisted of two presentations followed by a discussion/question and answer period. The session was arranged to convey what is known about avian migration, particularly in the eastern US. The first presentation ''Migration Ecology: Issues of Scale and Behavior'' by Sarah Mabey frames the issue of migratory bird interactions with wind energy facilities from an ecological perspective: when, where, and why are migrant bird species vulnerable to wind turbine collision. The second presentation ''Radar Studies of Nocturnal Migration at Wind Sites in the Eastern US'' by Brian Cooper reported on radar studies conducted at wind sites in the eastern US, including Mount Storm, Clipper Wind, and others.

  3. After hours: temporal developments at the edge of the analytic session.

    PubMed

    Spero, Moshe Halevi

    2010-04-01

    The author presents case material of a rigid, schizoid patient who at some point during his treatment began to come late for sessions. He once missed an entire session only to appear at the door after the scheduled hour had passed; this "timing" was evidently intentional. Discussion centers upon the meaning of this kind of phenomenon; it seemed that this particular patient was trying to remold the analytic frame, and the analyst's temporal experience, in accordance with a deeply primitive experience of the "shape" of time, and thereby carve out a sanctuary into which he could sequester his idiosyncratic sense of nontime until circumstances enabled further progress toward more mature symbolization of time. PMID:20496838

  4. Development of a wireless displacement measurement system using acceleration responses.

    PubMed

    Park, Jong-Woong; Sim, Sung-Han; Jung, Hyung-Jo; Spencer, Billie F

    2013-01-01

    Displacement measurements are useful information for various engineering applications such as structural health monitoring (SHM), earthquake engineering and system identification. Most existing displacement measurement methods are costly, labor-intensive, and have difficulties particularly when applying to full-scale civil structures because the methods require stationary reference points. Indirect estimation methods converting acceleration to displacement can be a good alternative as acceleration transducers are generally cost-effective, easy to install, and have low noise. However, the application of acceleration-based methods to full-scale civil structures such as long span bridges is challenging due to the need to install cables to connect the sensors to a base station. This article proposes a low-cost wireless displacement measurement system using acceleration. Developed with smart sensors that are low-cost, wireless, and capable of on-board computation, the wireless displacement measurement system has significant potential to impact many applications that need displacement information at multiple locations of a structure. The system implements an FIR-filter type displacement estimation algorithm that can remove low frequency drifts typically caused by numerical integration of discrete acceleration signals. To verify the accuracy and feasibility of the proposed system, laboratory tests are carried out using a shaking table and on a three storey shear building model, experimentally confirming the effectiveness of the proposed system. PMID:23881123

  5. Rural Development: Report on Congressional Activities in 15 Major Categories in the 92d Congress, 1st Session. Committee Print, 92d Congress, 2d Session, February 3, 1972.

    ERIC Educational Resources Information Center

    Robbins, Frances

    This report reviews the legislative progress through December 31, 1971 of the rural development bills introduced in the U.S. Senate and House during the first session of the 92d Congress. For purposes of organization, this report presents 15 major rural development categories and limits this review to those bills and bill categories directed at…

  6. A World Fit for Children: Millennium Development Goals; Special Session on Children Documents; The Convention on the Rights of the Child.

    ERIC Educational Resources Information Center

    United Nations Children's Fund, New York, NY.

    In May 2002, participants at the United Nations General Assembly's Special Session on Children committed to a set of specific goals for children and youth and a basic framework for meeting these goals. This report compiles the commitments that were part of the Special Session: (1) the Millennium Development Goals, earlier pledged to by all 189…

  7. Development of an artificial climatic complex accelerated corrosion tester and investigation of complex accelerated corrosion test methods

    SciTech Connect

    Li, J.; Li, M.; Sun, Z. )

    1999-05-01

    During recent decades, accelerated corrosion test equipment and methods simulating atmospheric corrosion have been developed to incorporate the many factors involved in complex accelerated corrosion. A new accelerated corrosion tester was developed to simulate various kinds of atmospheric corrosion environments. The equipment can be used to simulate various types of atmospheric corrosion environments with up to eight factors and can be used to carry out 18 kinds of standard corrosion and environmental tasks.

  8. Abstracts of SIG Sessions.

    ERIC Educational Resources Information Center

    Proceedings of the ASIS Annual Meeting, 1997

    1997-01-01

    Presents abstracts of SIG Sessions. Highlights include digital collections; information retrieval methods; public interest/fair use; classification and indexing; electronic publication; funding; globalization; information technology projects; interface design; networking in developing countries; metadata; multilingual databases; networked…

  9. Application of accelerators for the research and development of scintillators.

    PubMed

    Shibuya, Kengo; Koshimizu, Masanori; Asai, Keisuke; Muroya, Yusa; Katsumura, Yosuke; Inadama, Naoko; Yoshida, Eiji; Nishikido, Fumihiko; Yamaya, Taiga; Murayama, Hideo

    2007-08-01

    We introduce experimental systems which use accelerators to evaluate scintillation properties such as scintillation intensity, wavelength, and lifetime. A single crystal of good optical quality is often unavailable during early stages in the research and development (R&D) of new scintillator materials. Because of their beams' high excitation power and/or low penetration depth, accelerators facilitate estimation of the properties of early samples which may only be available as powders, thin films, and very small crystals. We constructed a scintillation spectrum measurement system that uses a Van de Graaff accelerator and an optical multichannel analyzer to estimate the relative scintillation intensity. In addition, we constructed a scintillation time profile measurement system that uses an electron linear accelerator and a femtosecond streak camera or a microchannel plate photomultiplier tube followed by a digital oscilloscope to determine the scintillation lifetimes. The time resolution is approximately 10 ps. The scintillation spectra or time profiles can be obtained in a significantly shorter acquisition time in comparison with that required by conventional measuring systems. The advantages of the systems described in this study can significantly promote the R&D of novel scintillator materials. PMID:17764319

  10. Advances in Parallel Electromagnetic Codes for Accelerator Science and Development

    SciTech Connect

    Ko, Kwok; Candel, Arno; Ge, Lixin; Kabel, Andreas; Lee, Rich; Li, Zenghai; Ng, Cho; Rawat, Vineet; Schussman, Greg; Xiao, Liling; /SLAC

    2011-02-07

    Over a decade of concerted effort in code development for accelerator applications has resulted in a new set of electromagnetic codes which are based on higher-order finite elements for superior geometry fidelity and better solution accuracy. SLAC's ACE3P code suite is designed to harness the power of massively parallel computers to tackle large complex problems with the increased memory and solve them at greater speed. The US DOE supports the computational science R&D under the SciDAC project to improve the scalability of ACE3P, and provides the high performance computing resources needed for the applications. This paper summarizes the advances in the ACE3P set of codes, explains the capabilities of the modules, and presents results from selected applications covering a range of problems in accelerator science and development important to the Office of Science.

  11. Development of X-Band Dielectric-Loaded Accelerating Structures

    SciTech Connect

    Gold, S. H.; Jing, C.; Kanareykin, A.; Gai, W.; Konecny, R.; Power, J. G.; Kinkead, A. K.

    2010-11-04

    This paper presents a progress report on the development and testing of X-band dielectric-loaded accelerating structures. Recent tests on several quartz DLA structures with different inner diameters are reported. Designs for gap-free DLA structures are presented. Also, planned new experiments are discussed, including higher gradient traveling-wave and standing-wave structures and special grooved structures for multipactor suppression.

  12. Session introduction

    NASA Astrophysics Data System (ADS)

    Bonfante, Antonello; Brook, Anna; D'Auria, Luca; Tizzani, Pietro

    2016-04-01

    Environmental processes cover spatial and temporal scales of different orders of magnitude. Quantitative and qualitative models, covering differentresearch fields, have provided important insights as to the interplay between processes acting in environmental systems at different scales, such asglobal geodynamics processes, volcanology, seismology, earth's critical zone, soil hydrology, landslide phenomena, etc. In this context, the proposed session will emphasize the multiscale nature of environmental issues, relevant for both natural and anthropic processes, and the need for knowledge sharing between different scientific communities. The session will be introduced by em.prof. Johan Bouma.

  13. Developments in Laser and Plasma-Based Accelerators

    NASA Astrophysics Data System (ADS)

    Downer, Michael

    2001-04-01

    The explosive growth of multiterawatt laser technology combined with the increasing size and cost of conventional RF particle accelerators has driven intense research into more compact laser-driven and/or plasma based acceleration concepts. Although schemes for direct laser acceleration without plasmas or, conversely, plasma acceleration without lasers have been studied, the greatest recent progress has been made with concepts that combine lasers and plasmas [1]. Tajima and Dawson [2] proposed in 1979 that a sufficiently intense single laser pulse of duration t ω_p-1, or a pair of laser pulses with Δω ω_p, could be efficiently drive a longitudinal electron plasma wave with phase velocity approaching c via the ponderomotive force. Charged particles that "surf" such waves experience accelerating gradients (E 10^9 V/cm) as much as a thousand times greater than conventional RF accelerators. Numerous experiments have now demonstrated acceleration of up to 10^9 electrons per laser pulse to energies exceeding 100 MeV, with wide energy spread, but competitive beam emittance. Such sources have proven useful for nuclear activation analysis in their current form. However for such accelerators to be useful to a wider community, including high energy physics, key challenges must be addressed. These include: 1) Guiding terawatt laser pulses. Achieving useful laser intensities requires focusing, thus limiting interaction length to < 1 mm, whereas interaction lengths of several cm are needed to use laser energy efficiently and reach GeV acceleration in a single stage. Several groups are now developing high-throughput plasma "fibers" that have supported peak powers near a terawatt over > 1 cm without distortion [3]. 2) Phased injection. Since plasma waves with useful gradients have wavelengths of micron dimensions, charged particles must be injected with unprecedented spatial and temporal precision to achieve a monochromatic output beam. Several groups are developing new laser

  14. Development of a remote control console for the HHIRF 25-MV tandem accelerator

    SciTech Connect

    Hasanul Basher, A.M.

    1991-09-01

    The CAMAC-based control system for the 25-MV Tandem Accelerator at HHIRF uses two Perkin-Elmer, 32-bit minicomputers: a message-switching computer and a supervisory computer. Two operator consoles are located on one of the six serial highways. Operator control is provided by means of a console CRT, trackball, assignable shaft encoders and meters. The message-switching computer transmits and receives control information on the serial highways. At present, the CRT pages with updated parameters can be displayed and parameters can be controlled only from the two existing consoles, one in the Tandem control room and the other in the ORIC control room. It has become necessary to expand the control capability to several other locations in the building. With the expansion of control and monitoring capability of accelerator parameters to other locations, the operators will be able to control and observe the result of the control action at the same time. Since the new control console will be PC-based, the existing page format will be changed. The PC will be communicating with the Perkin-Elmer through RS-232 and a communication software package. Hardware configuration has been established, a communication software program that reads the pages from the shared memory has been developed. In this paper, we present the implementation strategy, works completed, existing and new page format, future action plans, explanation of pages and use of related global variables, a sample session, and flowcharts.

  15. Panel Sessions.

    ERIC Educational Resources Information Center

    Proceedings of the ASIS Mid-Year Meeting, 1992

    1992-01-01

    Lists the speakers and summarizes the issues addressed for 12 panel sessions on topics related to networking, including libraries and national networks, federal national resources and energy programs, multimedia issues, telecommuting, remote image serving, accessing the Internet, library automation, scientific information, applications of Z39.50,…

  16. New Developments in the Simulation of Advanced Accelerator Concepts

    SciTech Connect

    Bruhwiler, David L.; Cary, John R.; Cowan, Benjamin M.; Paul, Kevin; Mullowney, Paul J.; Messmer, Peter; Geddes, Cameron G. R.; Esarey, Eric; Cormier-Michel, Estelle; Leemans, Wim; Vay, Jean-Luc

    2009-01-22

    Improved computational methods are essential to the diverse and rapidly developing field of advanced accelerator concepts. We present an overview of some computational algorithms for laser-plasma concepts and high-brightness photocathode electron sources. In particular, we discuss algorithms for reduced laser-plasma models that can be orders of magnitude faster than their higher-fidelity counterparts, as well as important on-going efforts to include relevant additional physics that has been previously neglected. As an example of the former, we present 2D laser wakefield accelerator simulations in an optimal Lorentz frame, demonstrating >10 GeV energy gain of externally injected electrons over a 2 m interaction length, showing good agreement with predictions from scaled simulations and theory, with a speedup factor of {approx}2,000 as compared to standard particle-in-cell.

  17. New Developments in the Simulation of Advanced Accelerator Concepts

    SciTech Connect

    Paul, K.; Cary, J.R.; Cowan, B.; Bruhwiler, D.L.; Geddes, C.G.R.; Mullowney, P.J.; Messmer, P.; Esarey, E.; Cormier-Michel, E.; Leemans, W.P.; Vay, J.-L.

    2008-09-10

    Improved computational methods are essential to the diverse and rapidly developing field of advanced accelerator concepts. We present an overview of some computational algorithms for laser-plasma concepts and high-brightness photocathode electron sources. In particular, we discuss algorithms for reduced laser-plasma models that can be orders of magnitude faster than their higher-fidelity counterparts, as well as important on-going efforts to include relevant additional physics that has been previously neglected. As an example of the former, we present 2D laser wakefield accelerator simulations in an optimal Lorentz frame, demonstrating>10 GeV energy gain of externally injected electrons over a 2 m interaction length, showing good agreement with predictions from scaled simulations and theory, with a speedup factor of ~;;2,000 as compared to standard particle-in-cell.

  18. Research and Development for Ultra-High Gradient Accelerator Structures

    NASA Astrophysics Data System (ADS)

    Tantawi, Sami G.; Dolgashev, Valery; Higashi, Yasuo; Spataro, Bruno

    2010-11-01

    Research on the basic physics of high-gradient, high frequency accelerator structures and the associated RF/microwave technology are essential for the future of discovery science, medicine and biology, energy and environment, and national security. We will review the state-of-the-art for the development of high gradient linear accelerators. We will present the research activities aimed at exploring the basic physics phenomenon of RF breakdown. We present the experimental results of a true systematic study in which the surface processing, geometry, and materials of the structures have been varied, one parameter at a time. The breakdown rate or alternatively, the probability of breakdown/pulse/meter has been recorded for different operating parameters. These statistical data reveal a strong dependence of breakdown probability on surface magnetic field, or alternatively on surface pulsed heating. This is in contrast to the classical view of electric field dependence.

  19. Development of the brine shrimp Artemia is accelerated during spaceflight

    NASA Technical Reports Server (NTRS)

    Spooner, B. S.; Metcalf, J.; DeBell, L.; Paulsen, A.; Noren, W.; Guikema, J. A.

    1994-01-01

    Developmentally arrested brine shrimp cysts have been reactivated during orbital spaceflight on two different Space Shuttle missions (STS-50 and STS-54), and their subsequent development has been compared with that of simultaneously reactivated ground controls. Flight and control brine shrimp do not significantly differ with respect to hatching rates or larval morphology at the scanning and transmission EM levels. A small percentage of the flight larvae had defective nauplier eye development, but the observation was not statistically significant. However, in three different experiments on two different flights, involving a total of 232 larvae that developed in space, a highly significant difference in degree of flight to control development was found. By as early as 2.25 days after reactivation of development, spaceflight brine shrimp were accelerated, by a full instar, over ground control brine shrimp. Although developing more rapidly, flight shrimp grew as long as control shrimp at each developmental instar or stage.

  20. Development of an accelerating-piston implosion-driven launcher

    NASA Astrophysics Data System (ADS)

    Huneault, Justin; Loiseau, Jason; Higgins, Andrew

    2013-06-01

    The ability to soft-launch projectiles at velocities exceeding 10 km/s is of interest to several scientific fields, including orbital debris impact testing and equation of state research. Current soft-launch technologies have reached a performance plateau below this operating range. The energy and power density of high explosives provides a possible avenue to reach this velocity if used to dynamically compress a light driver gas to significantly higher pressures and temperatures compared to light-gas guns. In the implosion-driven launcher (IDL), linear implosion of a pressurized tube drives a strong shock into the gas ahead of the tube pinch, thereby forming an increasingly long column of compressed gas which can be used to propel a projectile. The McGill IDL has demonstrated the ability to launch a 0.1-g projectile to 9.1 km/s. This study focuses on the implementation of a novel launch cycle wherein the explosively driven pinch is accelerated down the length of the tube in order to maintain a relatively constant projectile base pressure early in the launch cycle. The experimental development of an accelerating driver which utilizes an explosive lens to phase the detonation wave is presented. The design and experimental performance of an accelerating-piston IDL is also discussed.

  1. Development of a sealed-accelerator-tube neutron generator

    PubMed

    Verbeke; Leung; Vujic

    2000-10-01

    Sealed-accelerator-tube neutron generators are being developed in Lawrence Berkeley National Laboratory (LBNL) for applications ranging from neutron radiography to boron neutron capture therapy and neutron activation analysis. The new generation of high-output neutron generators is based on the D-T fusion reaction, producing 14.1-MeV neutrons. The main components of the neutron tube--the ion source, the accelerator and the target--are all housed in a sealed metal container without external pumping. Thick-target neutron yield computations are performed in this paper to estimate the neutron yield of titanium and scandium targets. With an average deuteron beam current of 1 A and an energy of 120 keV, a time-averaged neutron production of approximately 10(14) n/s can be estimated for a tritiated target, for both pulsed and cw operations. In mixed deuteron/triton beam operation, a beam current of 2 A at 150 keV is required for the same neutron output. Recent experimental results on ion sources and accelerator columns are presented and discussed. PMID:11003523

  2. Development and Implementation of an Advising Program’s Meet-and-Greet Session

    PubMed Central

    Candelario, Danielle M.; Bridgeman, Mary Barna

    2015-01-01

    Objective. To describe the implementation and perceptions of an advising program’s meet-and-greet session on student/faculty interactions. Design. Student advisees and faculty advisors attended a meet-and-greet program designed to facilitate introductions. Two online surveys evaluating program perceptions were electronically distributed to participants. Assessment. Twenty-eight advisors and 226 students attended; 17 faculty members and 42% (n=95) of students completed the survey. Advisors and advisees found the program valuable (100%, 85%) and recommended holding it again (100%, 93%), respectively. Most advisors agreed that the event improved success in meeting advisees while reducing time needed to schedule and meet with advisees. Students felt more comfortable contacting advisors after participating, with 83% agreeing it was more convenient than scheduling separate meeting times. Conclusion. An advising meet-and-greet program facilitated initial advisee/advisor meetings while reducing self-reported faculty time/resources. This activity could be implemented by other institutions seeking to promote student advising relationships. PMID:26889062

  3. Latest Diagnostic Electronics Development for the PROSCAN Proton Accelerator

    SciTech Connect

    Duperrex, P.A.; Frei, U.; Gamma, G.; Mueller, U.; Rezzonico, L.

    2004-11-10

    New VME-based diagnostic electronics are being developed for PROSCAN, a proton accelerator for medical application presently under construction at PSI. One new development is a VME-based multi-channel logarithmic amplifier for converting current to voltage (LogIV). The LogIV boards are used for measuring current from the multiple wire (harp) profile monitors. The LogIV calibration method, current dependant bandwidth and temperature stability are presented. Another development is a BPM front end, based on the newest digital receiver techniques. Features of this new system are the remote control of the preamplifier stage and the continuous monitoring of each individual signal overall gain. Characteristics of the developed prototype are given.

  4. Development of the accelerator-driven energy production concept

    SciTech Connect

    Venneri, F.; Beard, C.; Bowman, C.

    1996-10-01

    This is the final report of a three-year, Laboratory-Directed Research and Development (LDRD) project at the Los Alamos National Laboratory (LANL). Accelerator Driven Transmutation Technology (ADTT) offers a means of generating nuclear energy in a clean, safe way that can be attractive to the general public. However, there are issues associated with the energy story (both at the system level and technical detail) that have to be seriously addressed before the scientific community, the public, and potential industrial sponsors can be compellingly convinced of its cost/benefit.

  5. Design and development of pulsed electron beam accelerator 'AMBICA - 600'

    NASA Astrophysics Data System (ADS)

    Verma, Rishi; Deb, Pankaj; Shukla, Rohit; Sharma, Surender; Shyam, Anurag

    2012-11-01

    Short duration, high power pulses with fast rise time and good flat-top are essentially required for driving pulsed electron beam diodes. To attain this objective, a dual resonant Tesla transformer based pulsed power accelerator 'AMBICA-600' has been developed. In this newly developed system, a coaxial water line is charged through single turn Tesla transformer that operates in the dual resonant mode. For making the accelerator compact, in the high power pulse forming line, water has been used as dielectric medium because of its high dielectric constant, high dielectric strength and high energy density. The coaxial waterline can be pulsed charged up to 600kV, has impedance of ~5Ω and generates pulse width of ~60ns. The integrated system is capable of producing intense electron beam of 300keV, 60kA when connected to impedance matched vacuum diode. In this paper, system hardware details and experimental results of gigawatt electron beam generation have been presented.

  6. Improving and Accelerating Drug Development for Nervous System Disorders

    PubMed Central

    Pankevich, Diana E.; Altevogt, Bruce M.; Dunlop, John; Gage, Fred H.; Hyman, Steve E.

    2014-01-01

    Advances in the neurosciences have placed the field in the position where it is poised to significantly reduce the burden of nervous system disorders. However, drug discovery, development and translation for nervous system disorders still pose many unique challenges. The key scientific challenges can be summarized as follows: mechanisms of disease, target identification and validation, predictive models, biomarkers for patient stratification and as endpoints for clinical trials, clear regulatory pathways, reliability and reproducibility of published data, and data sharing and collaboration. To accelerate nervous system drug development the Institute of Medicine’s Forum on Neuroscience and Nervous System Disorders has hosted a series of public workshops that brought together representatives of industry, government (including both research funding and regulatory agencies), academia, and patient groups to discuss these challenges and offer potential strategies to improve the translational neuroscience. PMID:25442933

  7. Development of high purity niobium used in SRF accelerating cavity

    NASA Astrophysics Data System (ADS)

    Chen, Lin; Xie, Wei-Ping; Li, Ming-Yang; He, Ji-Lin; Fan, Hui-Ru; Zhang, Bao-Cheng; He, Fei-Si; Zhao, Kui; Chen, Jia-Er; Liu, Ke-Xin

    2008-12-01

    Niobium is widely used in SRF (Superconducting Radio Frequency) cavities due to its excellent superconductivity and workability. With the continuous development of technology, higher demands of material are raised. One of the key issues is that RRR (Residual Resistance Ratio) of the Nb material should be more than 300, which requires that the Nb ingot have even higher RRR. This article introduces the development and the experimental results of high purity niobium in OTIC in Ningxia (Ningxia Orient Tantalum Industry Co. Ltd.), and the test results of the single cell TESLA (Tera Electron volt energy Superconducting Linear Accelerator) shaped cavity manufactured by Peking University using Nb material from OTIC. Supported by National Basic Research Program of China (2002CB713600)

  8. Summary report: Working Group 2 on 'Plasma Based Acceleration Concepts'

    SciTech Connect

    Leemans, W. P.; Esarey, E.

    1999-07-12

    A summary of the talks, papers and discussion sessions presented in the Working Group on Plasma Based Acceleration Concepts is given within the context of the progress towards a 1 GeV laser driven accelerator module. The topics covered within the Working Group were self-modulated laser wakefield acceleration, standard laser wakefield acceleration, plasma beatwave acceleration, laser guiding and wake excitation in plasma channels, plasma wakefield acceleration, plasma lenses and optical injection techniques for laser wakefield accelerators. An overview will be given of the present status of experimental and theoretical progress as well as an outlook towards the future physics and technological challenges for the development of an optimized accelerator module.

  9. Highly Productive Application Development with ViennaCL for Accelerators

    NASA Astrophysics Data System (ADS)

    Rupp, K.; Weinbub, J.; Rudolf, F.

    2012-12-01

    The use of graphics processing units (GPUs) for the acceleration of general purpose computations has become very attractive over the last years, and accelerators based on many integrated CPU cores are about to hit the market. However, there are discussions about the benefit of GPU computing when comparing the reduction of execution times with the increased development effort [1]. To counter these concerns, our open-source linear algebra library ViennaCL [2,3] uses modern programming techniques such as generic programming in order to provide a convenient access layer for accelerator and GPU computing. Other GPU-accelerated libraries are primarily tuned for performance, but less tailored to productivity and portability: MAGMA [4] provides dense linear algebra operations via a LAPACK-comparable interface, but no dedicated matrix and vector types. Cusp [5] is closest in functionality to ViennaCL for sparse matrices, but is based on CUDA and thus restricted to devices from NVIDIA. However, no convenience layer for dense linear algebra is provided with Cusp. ViennaCL is written in C++ and uses OpenCL to access the resources of accelerators, GPUs and multi-core CPUs in a unified way. On the one hand, the library provides iterative solvers from the family of Krylov methods, including various preconditioners, for the solution of linear systems typically obtained from the discretization of partial differential equations. On the other hand, dense linear algebra operations are supported, including algorithms such as QR factorization and singular value decomposition. The user application interface of ViennaCL is compatible to uBLAS [6], which is part of the peer-reviewed Boost C++ libraries [7]. This allows to port existing applications based on uBLAS with a minimum of effort to ViennaCL. Conversely, the interface compatibility allows to use the iterative solvers from ViennaCL with uBLAS types directly, thus enabling code reuse beyond CPU-GPU boundaries. Out-of-the-box support

  10. Development of an annular arc accelerator shock tube driver

    NASA Technical Reports Server (NTRS)

    Leibowitz, L. P.

    1973-01-01

    An annular arc accelerator (ANAA) shock tube driver has been developed that deposits the energy of an arc discharge into a flowing gas, which then expands and cools without any delay for the opening of a diaphragm. A simplified one-dimensional flow analysis of the ANAA shock tube has been performed, which indicates that shock velocities greater than 40 km/sec may be obtained using a 300-kJ capacitor bank. The ANAA driver consists of a high-pressure driver, an expansion section, and an electrode section. In operation, the cold gas driver is pressurized until the diaphragm bursts, sending a pressure front down the expansion tube to the arc section. When the accelerated flow arrives at the electrode section, a 100-capacitor, 300-kJ capacitor bank is discharged either by breaking an insulating diaphragm between the electrodes or by the triggering of a series of external switches. Shock velocities of 28 km/sec have been obtained, and modifications are described that are expected to improve performance.

  11. Development of Dielectric-Based High Gradient Accelerating Structures

    SciTech Connect

    Jing, C.; Gai, W.; Konecny, R.; Power, J.; Liu, W.; Gold, S. H.; Kinkead, A. K.; Kanareykin, A.; Kazakov, S.

    2006-11-27

    High gradient accelerating structures using dielectric-lined circular waveguides have been developed for a number of years at Argonne National Laboratory. In this article, we first report the experimental results of high power rf testing on the quartz based Dielectric-Loaded Accelerating (DLA) structure carried out on Feb. 2006 at the Naval Research Laboratory. The motivation for this experiment is to test the multipactor effect on different materials under high power and high vacuum condition. Up to 12 MW pulsed rf went through the tube without breakdown. Multipactor appeared during the experiment but with different features compared to other materials like alumina. Photomultiplier Tube (PMT) measurements were introduced into the experiment for the first time to observe the light emission time and intensity. In the second part of this paper, ways to achieve higher gradient for DLA structures are proposed: 1) smaller ID and longitudinal gap free DLA structures to reduce multipactor and obtain higher gradient; 2) new coaxial type coupler to avoid dielectric gap and improve impedance matching; 3) double layered DLA structure to reduce rf loss and enhance shunt impedance as well.

  12. Session Introduction

    NASA Astrophysics Data System (ADS)

    Eliane Lessner, Co-Chair:

    2009-03-01

    A panel discussion session providing a worldwide assessment of the status and experiences of women in physics, paying attention to the different cultures and environments they work in and to how the age of the physicist affects their perspective. We will hear about women physicists in Korea in particular and Asia in general, in Egypt in particular and Africa in general, and in the Caribbean. Six invited speakers will present analyses of the progress being made in promoting women in physics from their personal experiences and as assessed from their participation in the Third International Conference on Women In Physics (ICWIP2008) convened in Seoul, Korea in October 2008. From Albania to Zimbabwe, with representation of all the continents, ICWIP2008 congregated 283 women and men physicists from 57 countries to share the participants' scientific accomplishments and evaluate international progress in improving the status of women in physics. This three-hour session is organized jointly by the Committee on the Status of Women in Physics of the APS (CSWP) and the Forum on International Physics of the APS (FIP). Audience participation in the panel discussion will be strongly encouraged.

  13. Developing an Accelerator Driven System (ADS) based on electron accelerators and heavy water

    NASA Astrophysics Data System (ADS)

    Feizi, H.; Ranjbar, A. H.

    2016-02-01

    An ADS based on electron accelerators has been developed specifically for energy generation and medical applications. Monte Carlo simulations have been performed using FLUKA code to design a hybrid electron target and the core components. The composition, geometry of conversion targets and the coolant system have been optimized for electron beam energies of 20 to 100 MeV . Furthermore, the photon and photoneutron energy spectra, distribution and energy deposition for various incoming electron beam powers have been studied. Light-heavy water of various mixtures have been used as heat removal for the targets, as γ-n converters and as neutron moderators. We have shown that an electron LINAC, as a neutron production driver for ADSs, is capable of producing a neutron output of > 3.5 × 1014 (n/s/mA). Accordingly, the feasibility of an electron-based ADS employing the designed features is promising for energy generation and high intense neutron production which have various applications such as medical therapies.

  14. Development of an Accelerator Mass Spectrometer based on a Cyclotron

    SciTech Connect

    Kim, Dogyun; Bhang, Hyeongchan; Kim, Jongwon

    2011-12-13

    An accelerator mass spectrometer based on a cyclotron has been developed, and a prototype of the injection beam line has been constructed. Mass resolution of the cyclotron is designed to be over 4000. A sawtooth RF buncher in the beam line and a flat-topping RF system for the cyclotron were utilized to enhance beam transmission efficiency, which is a primary factor for improvement compared to previous cyclotron mass spectrometers. The injection beam line comprises an ion source, Einzel lens, RF buncher, 90 deg. dipole magnet and a slit box containing beam diagnostic devices. A carbon beam was measured at the location of the slit box, and beam phase spaces will be measured. The design of a cyclotron magnet was done, and orbit tracking was carried out using cyclotron optics codes. A scheme of radial injection was chosen to place a beam on the equilibrium orbit of the cyclotron. The injection scheme will be optimized after the beam measurements are completed.

  15. Management Development. Symposium 15. [Concurrent Symposium Session at AHRD Annual Conference, 2000.

    ERIC Educational Resources Information Center

    2000

    Three presentations are provided from Symposium 15, Management Development, of the Academy of Human Resource Development (HRD) 2000 Conference Proceedings. "Conceptualizing Global Leadership from Multiple Perspectives: An Analysis of Behavioral Ratings" (Allan H. Church) examines the underlying nature of global leadership behavior using…

  16. Developing Employee Competence. Symposium 25. [Concurrent Symposium Session at AHRD Annual Conference, 2000.

    ERIC Educational Resources Information Center

    2000

    This packet contains three papers from a symposium on developing employee competence. The first paper, "Coaching in Organizations: Self-Assessment of Competence" (Gary N. McLean, Min-Hsun [Christine] Kuo), reports on development and pilot-testing of an instrument to identify the developmental needs of managers and peers to function more…

  17. Status and Future Developments in Large Accelerator Control Systems

    SciTech Connect

    Karen S. White

    2006-10-31

    Over the years, accelerator control systems have evolved from small hardwired systems to complex computer controlled systems with many types of graphical user interfaces and electronic data processing. Today's control systems often include multiple software layers, hundreds of distributed processors, and hundreds of thousands of lines of code. While it is clear that the next generation of accelerators will require much bigger control systems, they will also need better systems. Advances in technology will be needed to ensure the network bandwidth and CPU power can provide reasonable update rates and support the requisite timing systems. Beyond the scaling problem, next generation systems face additional challenges due to growing cyber security threats and the likelihood that some degree of remote development and operation will be required. With a large number of components, the need for high reliability increases and commercial solutions can play a key role towards this goal. Future control systems will operate more complex machines and need to present a well integrated, interoperable set of tools with a high degree of automation. Consistency of data presentation and exception handling will contribute to efficient operations. From the development perspective, engineers will need to provide integrated data management in the beginning of the project and build adaptive software components around a central data repository. This will make the system maintainable and ensure consistency throughout the inevitable changes during the machine lifetime. Additionally, such a large project will require professional project management and disciplined use of well-defined engineering processes. Distributed project teams will make the use of standards, formal requirements and design and configuration control vital. Success in building the control system of the future may hinge on how well we integrate commercial components and learn from best practices used in other industries.

  18. Staff development sessions. A strategy to facilitate nursing staff education with limited teaching resources.

    PubMed

    Kirsivali-Farmer, K

    1994-01-01

    A reduction in clinical nursing educator positions resulted in the need for the Department of Nursing to continue to facilitate the professional development of nursing staff members with limited resources. In this article, the author describes a program, developed by the central Nursing Education Department at The Toronto Hospital, that was offered to clinical resource nurses, nurse managers, patient care coordinators, and preceptors. These individuals could use the information to promote the development of nursing staff members at the unit level. Several topics were presented: self-directed learning, needs assessment, behavioral objectives, lesson plans, teaching strategies, educational program evaluation, and clinical evaluation. Program evaluations were positive, and 45% of the respondents indicated they had the opportunity to apply what they learned. PMID:7807245

  19. Microphysiological models of the developing nervous system (SOT workshop session overview)

    EPA Science Inventory

    Recent advances using human stem cells and other cells that can be ushered through differentiation and developmental maturation offer an unprecedented opportunity to develop predictive systems for toxicological assessment. The use of human cells is an advantage because there is n...

  20. International Aspects of Particle Accelerators

    NASA Astrophysics Data System (ADS)

    Sessler, Andrew

    2013-04-01

    The development of particle accelerators -- an activity that started about 1930 and is still on-going -- is very much an international activity. There have been international contributions to this development all along the way. The result is remarkably effective accelerators, for many different activities, spread throughout the world. Because many don't appreciate this story and, furthermore, that it is very much worthy of explicit recognition, this session and this talk have been organized. In the talk, a survey will be made of the start of accelerators: electrostatic machines, cyclotrons, betatrons, linacs, synchrotrons, and colliders. Then a brief survey will be given of the more important contributions to particle accelerators. For each of these concepts we shall discuss the physics behind the concept, the origin of the concept, and the places where development and implementation took place. Some of the various applications of accelerators will then be presented. Finally we shall show, in broad terms, the present distribution of particle accelerators.

  1. Session: Hard Rock Penetration

    SciTech Connect

    Tennyson, George P. Jr.; Dunn, James C.; Drumheller, Douglas S.; Glowka, David A.; Lysne, Peter

    1992-01-01

    This session at the Geothermal Energy Program Review X: Geothermal Energy and the Utility Market consisted of five presentations: ''Hard Rock Penetration - Summary'' by George P. Tennyson, Jr.; ''Overview - Hard Rock Penetration'' by James C. Dunn; ''An Overview of Acoustic Telemetry'' by Douglas S. Drumheller; ''Lost Circulation Technology Development Status'' by David A. Glowka; ''Downhole Memory-Logging Tools'' by Peter Lysne.

  2. Accelerating technology development through integrated computation and experimentation

    SciTech Connect

    Shekhawat, Dushyant; Srivastava, Rameshwar

    2013-01-01

    This special section of Energy & Fuels comprises a selection of papers presented at the topical conference “Accelerating Technology Development through Integrated Computation and Experimentation”, sponsored and organized by the United States Department of Energy’s National Energy Technology Laboratory (NETL) as part of the 2012 American Institute of Chemical Engineers (AIChE) Annual Meeting held in Pittsburgh, PA, Oct 28−Nov 2, 2012. That topical conference focused on the latest research and development efforts in five main areas related to fossil energy, with each area focusing on the utilization of both experimental and computational approaches: (1) gas separations (membranes, sorbents, and solvents for CO{sub 2}, H{sub 2}, and O{sub 2} production), (2) CO{sub 2} utilization (enhanced oil recovery, chemical production, mineralization, etc.), (3) carbon sequestration (flow in natural systems), (4) advanced power cycles (oxy-combustion, chemical looping, gasification, etc.), and (5) fuel processing (H{sub 2} production for fuel cells).

  3. Accelerating Adverse Outcome Pathway Development Using Publicly Available Data Sources.

    PubMed

    Oki, Noffisat O; Nelms, Mark D; Bell, Shannon M; Mortensen, Holly M; Edwards, Stephen W

    2016-03-01

    The adverse outcome pathway (AOP) concept links molecular perturbations with organism and population-level outcomes to support high-throughput toxicity (HTT) testing. International efforts are underway to define AOPs and store the information supporting these AOPs in a central knowledge base; however, this process is currently labor-intensive and time-consuming. Publicly available data sources provide a wealth of information that could be used to define computationally predicted AOPs (cpAOPs), which could serve as a basis for creating expert-derived AOPs in a much more efficient way. Computational tools for mining large datasets provide the means for extracting and organizing the information captured in these public data sources. Using cpAOPs as a starting point for expert-derived AOPs should accelerate AOP development. Coupling this with tools to coordinate and facilitate the expert development efforts will increase the number and quality of AOPs produced, which should play a key role in advancing the adoption of HTT testing, thereby reducing the use of animals in toxicity testing and greatly increasing the number of chemicals that can be tested. PMID:26809562

  4. Improvement of the IVS-INT01 sessions by source selection: development and evaluation of the maximal source strategy

    NASA Astrophysics Data System (ADS)

    Gipson, John; Baver, Karen

    2016-03-01

    The primary purpose of the International very long baseline interferometry (VLBI) Service for Geodesy and Astrometry Intensive sessions is the rapid estimation of UT1-TAI. Improving the robustness and the precision of the UT1 estimates from the Intensives is an important goal. The INT01 series, which usually uses the Kokee-Wettzell baseline and runs on weekdays, is the most regular IVS Intensive series. The United States Naval Observatory which schedules these sessions traditionally used a small list of strong sources. In 2009, the authors requested and received the use of nine IVS R&D sessions for the evaluation of a new strategy which draws on all sources mutually visible on the Kokee-Wettzell baseline. Analysis of these sessions was sufficiently promising that in July 2010, USNO began to alternate the use of the original and the new strategy in scheduling the INT01 sessions to assess the operational effectiveness of the proposed strategy. In this paper, we summarize our analysis of the R&D sessions, and we also analyze 2 years of operational INT01 sessions. Considered in toto, the new strategy performs as well as, or better than, the original strategy in terms of several measures of robustness and precision. Furthermore, the RMS difference of the UT1 estimates from the 1 h operational INTO1 sessions and concurrently run 24 h VLBI sessions is 21.0 \\upmu s, compared to 30.7 \\upmu s using the standard strategy, indicating that the new strategy is, on average, 30 % more accurate.

  5. Session 10: The Cerro Prieto Geothermal Field, Mexico: The Experiences Gained from Its Exploration and Development

    SciTech Connect

    Lippman, M.J.; Goldstein, N.E.; Halfman, S.E.; Witherspoon, P.A.

    1983-12-01

    The Cerro Prieto case study demonstrated the value of a multidisciplinary effort for exploring and developing a geothermal field. There was no problem in recognizing the geothermal potential of the Cerro Prieto area because of the many obvious surface manifestations. However, the delineation of the geothermal reservoir at depth was not so straightforward. Wells drilled near the abundant surface manifestations only produced fluids of relatively low enthalpy. Later it was determined that these zones of high heat loss corresponded to discharge areas where faults and fractures allowed thermal fluids to leak to the surface, and not to the main geothermal reservoir. The early gravity and seismic refraction surveys provided important information on the general structure of the area. Unaware of the existence of a higher density zone of hydrothermally altered sediments capping the geothermal reservoir, CFE interpreted a basement horst in the western part of the field and hypothesized that the bounding faults were controlling the upward flow of thermal fluids. Attempting to penetrate the sedimentary column to reach the ''basement horst'', CFE discovered the {alpha} geothermal reservoir (in well M-5). The continuation of the geothermal aquifer (actually the {beta} reservoir) east of the original well field was later confirmed by a deep exploration well (M-53). The experience of Cerro Prieto showed the importance of chemical ratios, and geothermometers in general, in establishing the subsurface temperatures and fluid flow patterns. Fluid chemical and isotopic compositions have also been helpful to determine the origin of the fluids, fluid-production mechanisms and production induced effects on the reservoir.

  6. Accelerated Nuclear Energy Materials Development with Multiple Ion Beams

    SciTech Connect

    Fluss, M J; Bench, G

    2009-08-19

    A fundamental issue in nuclear energy is the changes in material properties as a consequence of time, temperature, and neutron fluence. Usually, candidate materials for nuclear energy applications are tested in nuclear reactors to understand and model the changes that arise from a combination of atomic displacements, helium and hydrogen production, and other nuclear transmutations (e.g. fission and the production of fission products). Experiments may be carried out under neutron irradiation conditions in existing nuclear materials test reactors (at rates of 10 to 20 displacements per atom (DPA) per year or burn-up rates of a few percent per year for fertile fuels), but such an approach takes much too long for many high neutron fluence scenarios (300 DPA for example) expected in reactors of the next generation. Indeed it is reasonable to say that there are no neutron sources available today to accomplish sufficiently rapid accelerated aging let alone also provide the temperature and spectral characteristics of future fast spectrum nuclear energy systems (fusion and fission both). Consequently, materials research and development progress continues to be severely limited by this bottleneck.

  7. Development of Bipolar Pulse Accelerator for Pulsed Ion Beam Implantation to Semiconductor

    NASA Astrophysics Data System (ADS)

    Masugata, Katsumi; Kawahara, Yoshihiro; Mitsui, Chihiro; Kitamura, Iwao; Takahashi, Takakazu; Tanaka, Yasunori; Tanoue, Hisao; Arai, Kazuo

    2002-12-01

    To improve the purity of the ion beams new type of pulsed power ion accelerator named "bipolar pulse accelerator" was proposed. The accelerator consists of two acceleration gaps (an ion source gap and a post acceleration gap) and a drift tube, and a bipolar pulse is applied to the drift tube to accelerate the beam. In the accelerator intended ions are selectively accelerated and the purity of the ion beam is enhanced. As the first step of the development of the accelerator, a Br-type magnetically insulated acceleration gap is developed. The gap has an ion source of coaxial gas puff plasma gun on the grounded anode and a negative pulse is applied to the cathode to accelerate the ion beam. By using the plasma gun, ion source plasma (nitrogen) of current density around 100 A/cm2 is obtained. In the paper, the experimental results of the evaluation of the ion beam and the characteristics of the gap are shown with the principle and the design concept of the proposed accelerator.

  8. Accelerated molecular dynamics methods: introduction and recent developments

    SciTech Connect

    Uberuaga, Blas Pedro; Voter, Arthur F; Perez, Danny; Shim, Y; Amar, J G

    2009-01-01

    reaction pathways may be important, we return instead to a molecular dynamics treatment, in which the trajectory itself finds an appropriate way to escape from each state of the system. Since a direct integration of the trajectory would be limited to nanoseconds, while we are seeking to follow the system for much longer times, we modify the dynamics in some way to cause the first escape to happen much more quickly, thereby accelerating the dynamics. The key is to design the modified dynamics in a way that does as little damage as possible to the probability for escaping along a given pathway - i.e., we try to preserve the relative rate constants for the different possible escape paths out of the state. We can then use this modified dynamics to follow the system from state to state, reaching much longer times than we could reach with direct MD. The dynamics within any one state may no longer be meaningful, but the state-to-state dynamics, in the best case, as we discuss in the paper, can be exact. We have developed three methods in this accelerated molecular dynamics (AMD) class, in each case appealing to TST, either implicitly or explicitly, to design the modified dynamics. Each of these methods has its own advantages, and we and others have applied these methods to a wide range of problems. The purpose of this article is to give the reader a brief introduction to how these methods work, and discuss some of the recent developments that have been made to improve their power and applicability. Note that this brief review does not claim to be exhaustive: various other methods aiming at similar goals have been proposed in the literature. For the sake of brevity, our focus will exclusively be on the methods developed by the group.

  9. Confronting Professional Values and Ethical Issues: An Innovative Session on Development of a Casebook on Ethics and Integrity. Innovative Session 4. [Concurrent Innovative Session at AHRD Annual Conference, 2000.

    ERIC Educational Resources Information Center

    Burns, Janet Z.; Hatcher, Tim; Russ-Eft, Darlene

    The Academy of Human Resource Development (AHRD) Standards on Ethics and Integrity, which were first presented in 1999, constituted one of three new initiatives to take the AHRD to a new level of leadership in the HRD profession. Although the initial standards were intentionally brief and easy to read, their application in specific situations may…

  10. Accelerator developments since the ZGS by ZGS people

    SciTech Connect

    Cho, Y.

    1994-12-31

    The ZGS was a facility, as well as an organization, where people got together to pursue a common goal of doing exciting science of the day. In this note, the authors describe notable events related to accelerators and accelerator people since the closing of the ZGS program some 15 years ago. Many of the same ZGS people have been carrying out the state-of-the art accelerator work around the Laboratory with the same dedication that characterized their work in the earlier days. First the authors describe how the activities were re-organized after the closing of the ZGS, the migration of people, and the organizational evolution since that time. Doing this shows the similarity between the birth of the ZGS and the birth of the Advanced Photon Source (APS). Then, some of the accelerator work by the former ZGS people are described. These include: (1) Intense Pulsed Neutron Source (IPNS), (2) GeV Electron Microtron (GEM), (3) Wake Field Accelerator Test Facility, (4) Advanced Photon Source, and (5) IPNS Upgrade.

  11. Session: Offshore wind

    SciTech Connect

    Gaarde, Jette; Ram, Bonnie

    2004-09-01

    This session at the Wind Energy and Birds/Bats workshop consisted of two presentations. Due to time constraints, a discussion period was not possible. The session addressed the current state of offshore wind energy development. The first presentation ''Monitoring Program and Results: Horns Rev and Nysted'' by Jette Gaarde summarized selected environmental studies conducted to date at operating offshore wind turbine projects in Denmark and lessons from other offshore wind developments in Europe. Wildlife impacts studies from the Danish sites focused on birds, fish, and mammals. The second presentation ''What has the U.S. Wind Industry Learned from the European Example'' by Bonnie Ram provided an update on current permit applications for offshore wind developments in the U.S. as well as lessons that may be drawn from the European experience.

  12. Residual acceleration data on IML-1: Development of a data reduction and dissemination plan

    NASA Technical Reports Server (NTRS)

    Rogers, Melissa J. B.; Alexander, J. Iwan D.; Wolf, Randy

    1991-01-01

    A residual acceleration data analysis plan is developed that will allow principal investigators of low-gravity experiments to efficiently process their experimental results in conjunction with accelerometer data. The basic approach consisted of the following program of research: (1) identification of sensitive experiments and sensitivity ranges by order of magnitude estimates, numerical modelling, and investigator input; (2) research and development towards reduction, supplementation, and dissemination of residual acceleration data; and (3) implementation of the plan on existing acceleration data bases.

  13. Niobium resonator development for high-brightness ion beam acceleration

    SciTech Connect

    Delayen, J.R.; Bohn, C.L.; Roche, C.T.

    1990-01-01

    Two niobium resonant cavities for high-brightness ion beam acceleration have been constructed and tested. The first was based on a coaxial quarter-wave geometry and was optimized for phase velocity {beta}{sub o} = 0.15. This cavity, which resonates at 400 MHz in the fundamental mode, operated at an average (wall-to-wall) accelerating gradient of 12.9 MV/m under continuous-wave (cw) fields. At this gradient, a cavity Q of 1.4 {times} 10{sup 8} was measured. The second was based on a coaxial half-wave geometry and was optimized for {beta}{sub o} = 0.12. This cavity, which resonates at 355 MHz in the fundamental mode, operated at an average accelerating gradient of 18.0 MV/m under cw fields. This is the highest average accelerating gradient achieved to date in low-velocity structures designed for cw operation. At this gradient, a cavity Q of 1.2 {times} 10{sup 8} was measured.

  14. Developing and Maintaining Accelerated Degree Programs within Traditional Institutions.

    ERIC Educational Resources Information Center

    Husson, William J.; Kennedy, Tom

    2003-01-01

    Successful accelerated degree programs should be learner focused, market sensitive, accessible, and high quality. They should offer a variety of options and excellent customer service. Key elements include institutional purpose, decision-making process, curricular design, adjunct faculty, marketing, and promotional materials. (SK)

  15. E-beam accelerator cavity development for the ground-based free electron laser

    NASA Astrophysics Data System (ADS)

    Bultman, N. K.; Spalek, G.

    Los Alamos National Laboratory is designing and developing four prototype accelerator cavities for high power testing on the Modular Component Technology Development (MCTD) test stand at Boeing. These cavities provide the basis for the e-beam accelerator hardware that will be used in the Ground Based Free Electron Laser (GBFEL) to be sited at the White Sands Missile Range (WSMR) in New Mexico.

  16. On the Boundaries of the Acceleration of the Development of Intelligence.

    ERIC Educational Resources Information Center

    Kingma, Johannes; Tomic, Welko

    This paper examines the possibility of accelerating the development of intelligence when applying stringent Piagetian standards to evaluate the effects of short- and long-term intervention or instruction programs. The paper reviews previous Genevan and American research that shows that development can be accelerated by means of only a few…

  17. Combination of Didactic Lectures with Problem-Based Learning Sessions in Physiology Teaching in a Developing Medical College in Nepal.

    ERIC Educational Resources Information Center

    Ghosh, Sarmishtha; Dawka, Violet

    2000-01-01

    Introduces the SPICES curriculum of the Manipal College of Medical Sciences in Nepal, which is student centered, problem based, integrated, community-based, elective oriented, and systematic. Reports that the majority of students opined that the combination of didactic lectures and problem-based learning sessions were definitely beneficial.…

  18. Analytical validation of accelerator mass spectrometry for pharmaceutical development

    PubMed Central

    Keck, Bradly D; Ognibene, Ted; Vogel, John S

    2011-01-01

    The validation parameters for pharmaceutical analyses were examined for the accelerator mass spectrometry measurement of 14C/C ratio, independent of chemical separation procedures. The isotope ratio measurement was specific (owing to the 14C label), stable across samples storage conditions for at least 1 year, linear over four orders of magnitude with an analytical range from 0.1 Modern to at least 2000 Modern (instrument specific). Furthermore, accuracy was excellent (between 1 and 3%), while precision expressed as coefficient of variation was between 1 and 6% determined primarily by radiocarbon content and the time spent analyzing a sample. Sensitivity, expressed as LOD and LLOQ was 1 and 10 attomoles of 14C, respectively (which can be expressed as compound equivalents) and for a typical small molecule labeled at 10% incorporated with 14C corresponds to 30 fg equivalents. Accelerator mass spectrometry provides a sensitive, accurate and precise method of measuring drug compounds in biological matrices. PMID:21083256

  19. High Temperature μSR Experiments for Accelerator Developments

    NASA Astrophysics Data System (ADS)

    Ohmori, Chihiro; Koda, Akihiro; Miyake, Yasuhiro; Nishiyama, Kusuo; Shimomura, Koichiro; Schnase, Alexander; Ezura, Eiji; Hara, Keigo; Hasegawa, Katsushi; Nomura, Masahiro; Shimada, Taihei; Takata, Koji; Tamura, Fumihiko; Toda, Makoto; Yamamoto, Masanobu; Yoshii, Masahito

    High temperature μSR is a powerful technique to study magnetic materials. In J-PARC accelerator synchrotrons, the Rapid Cycling Synchrotron (RCS) and Main Ring (MR), a unique magnetic alloy-loaded cavity is used for the beam acceleration and much higher field gradient has been achieved. Such high field gradient cavities made a compact RCS possible by reducing the length for beam acceleration. Now, further upgrades of the J-PARC, RF cavities with higher RF voltage and less power loss in the magnetic core are needed for the MR. For the improvements of the magnetic property of magnetic alloy core, the high temperature μSR (muon Spin Rotation/Relaxation) was used to investigate the crystallization process of the material. Based on the measurement results, the test production of the large ring cores of a magnetic alloy, FT3L, was tried. The FT3L is the magnetic alloy which has two times better performance than the present one, FT3M. For the FT3L production, the magnetic annealing is needed to control the easy-magnetized axis of the crystalline. After the success of the test production, a mass production was started in the industry to replace all existing cavities in the MR. The first 5-cell FT3L cavity is assembled for the bench test before the installation in the accelerator tunnel. By the new cavities, the total RF voltage of J-PARC MR will be doubled to increase the beam power for neutrino experiment. In future, the cavities will be also used for the RCS to increase the beam power beyond 1 MW.

  20. TRI-SERVICE SITE CHARACTERIZATION AND ANALYSIS PENETROMETER SYSTEM (SCAPS) ACCELERATED SENSOR DEVELOPMENT PROJECT

    EPA Science Inventory

    In 1994, the Strategic Environmental Research and Development Program (SERDP) funded a Tri-Service effort to accelerate the development and fielding of environmental sensing technologies to extend the capabilities of the Site Characterization and Analysis Penetrometer System (SCA...

  1. Summary report: working group 2 on 'Plasma Based AccelerationConcepts'

    SciTech Connect

    Esarey, E.; Leemans, Wim

    1998-09-01

    A summary of the talks, papers and discussion sessions presented in the Working Group on Plasma Based Acceleration Concepts is given within the context of the progress towards a 1 GeV laser driven accelerator module. The topics covered within the Working Group were self-modulated laser wakefield acceleration, standard laser wakefield acceleration, plasma beatwave acceleration, laser guiding and wake excitation in plasma channels, plasma wakefield acceleration, plasma lenses and optical injection techniques for laser wakefield accelerators. An overview will be given of the present status of experimental and theoretical progress as well as an outlook towards the future physics and technological challenges for the development of an optimized accelerator module.

  2. Development of a 20-MeV Dielectric-Loaded Accelerator Test Facility

    SciTech Connect

    Gold, S.H.; Kinkead, A.K.; Gai, W.; Power, J.G.; Konecny, R.; Jing, C.G.; Tantawi, S.G.; Nantista, C.D.; Hu, Y.; Chen, H.; Tang, C.; Lin, Y.; Bruce, R.W.; Bruce, R.L.; Fliflet, A.W.; Lewis, D.; /Naval Research Lab, Wash., D.C. /LET Corp., Washington /Argonne /SLAC /Tsinghua U., Beijing

    2005-06-22

    This paper describes a joint project by the Naval Research Laboratory (NRL) and Argonne National Laboratory (ANL), in collaboration with the Stanford Linear Accelerator Center (SLAC), to develop a dielectric-loaded accelerator (DLA) test facility powered by a high-power 11.424-GHz magnicon amplifier. The magnicon can presently produce 25 MW of output power in a 250-ns pulse at 10 Hz, and efforts are in progress to increase this to 50 MW. The facility will include a 5 MeV electron inector being developed by the Accelerator Laboratory of Tsinghua University in Beijing, China. The DLA test structures are being developed by ANL, and some have undergone testing at NRL at gradients up to {approx} 8 MV/m. SLAC is developing a means to combine the two magnicon output arms, and to drive an injector and accelerator with separate control of the power ratio and relative phase. RWBruce Associates, Inc., working with NRl, is developing a means to join short ceramic sections into a continuous accelerator tube by ceramic brazing using an intense millimeter-wave beam. The installation and testing of the first dielectric-loaded test accelerator, including injector, DLA structure, and spectrometer, should take place within the next year. The facility will be used for testing DLA structures using a variety of materials and configurations, and also for testing other X-band accelerator concepts. The initial goal is to produce a compact 20 MeV dielectric-loaded test accelerator.

  3. Development of the Accelerator Mass Spectrometry technology at the Comenius University in Bratislava

    NASA Astrophysics Data System (ADS)

    Povinec, Pavel P.; Masarik, Jozef; Ješkovský, Miroslav; Kaizer, Jakub; Šivo, Alexander; Breier, Robert; Pánik, Ján; Staníček, Jaroslav; Richtáriková, Marta; Zahoran, Miroslav; Zeman, Jakub

    2015-10-01

    An Accelerator Mass Spectrometry (AMS) laboratory has been established at the Centre for Nuclear and Accelerator Technologies (CENTA) at the Comenius University in Bratislava comprising of a MC-SNICS ion source, 3 MV Pelletron tandem accelerator, and an analyzer of accelerated ions. The preparation of targets for 14C and 129I AMS measurements is described in detail. The development of AMS techniques for potassium, uranium and thorium analysis in radiopure materials required for ultra-low background underground experiments is briefly mentioned.

  4. Residual acceleration data on IML-1: Development of a data reduction and dissemination plan

    NASA Technical Reports Server (NTRS)

    Rogers, Melissa J. B.; Alexander, J. Iwan D.

    1993-01-01

    The research performed consisted of three stages: (1) identification of sensitive IML-1 experiments and sensitivity ranges by order of magnitude estimates, numerical modeling, and investigator input; (2) research and development towards reduction, supplementation, and dissemination of residual acceleration data; and (3) implementation of the plan on existing acceleration databases.

  5. Jefferson Lab Accelerator Operations Training and Development Program

    SciTech Connect

    Michael A. Epps

    2008-01-23

    The mission of the Jefferson Lab Operations Group is to provide safe and efficient delivery of high quality electron beam for Jefferson Laboratory's nuclear and accelerator physics programs. The Operations staff must be able to setup, transport, maintain, and troubleshoot beam to all three experimental halls in a safe, efficient, and expeditious manner. Due to the nature of shift work, high employee turnover is always as issue. This creates a unique situation where highly trained staff members must quickly be produced and maintained in order to meet the needs of the Laboratory. Some methods used to address this problem will be presented here.

  6. Session Overview

    NASA Astrophysics Data System (ADS)

    Spencer, Cherrill

    2010-02-01

    High-school teachers are amongst the most important contributors to the development of the science and technology workforce of the future. Many of the more than 23,000 US high-school physics teachers are not adequately prepared to teach the subject. Only one-third of them, for example, majored in physics or physics education. Can inadequate teacher preparation be a factor in the poor performance of US students on international assessments of their achievements in science and physics? Since 1995 the Trends in International Mathematics and Science Study (TIMSS) has been administered four times to many hundreds of thousands of students in over 60 countries. TIMSS is used to measure trends in the mathematics and science knowledge and skills of fourth- and eighth-graders. The Program for International Student Assessment (PISA) has been administered three times since 2000, it focuses on 15-year-olds' capabilities in reading literacy, mathematics literacy, and science literacy. TIMSS Advanced (1995) assessed school-leaving students who have had special preparation in advanced mathematics and physics. In all these studies the US students, including the Advanced Placement physics students, scored below the international average, sometimes in the bottom third of countries! Three speakers have been invited to talk about the physics K-12 education systems in other countries, one that consistently scores at the top of the PISA (Finland) or score much higher than the USA on TIMSS ( various Northern European countries) and significantly better on recent bi-lateral comparisons (China). What can we learn from the physics teaching systems in these high-scoring countries that might be applied in the USA? There will be a panel discussion following the 3 invited talks, audience participation will be encouraged. )

  7. Development of a low-energy beam transport system at KBSI heavy-ion accelerator

    NASA Astrophysics Data System (ADS)

    Bahng, Jungbae; Lee, Byoung-Seob; Sato, Yoichi; Ok, Jung-Woo; Park, Jin Yong; Yoon, Jang-Hee; Choi, Seyong; Won, Mi-Sook; Kim, Eun-San

    2015-01-01

    The Korea Basic Science Institute has developed a heavy ion accelerator for fast neutron radiography [1]. To meet the requirements for fast neutron generation, we have developed an accelerator system that consists of an electron cyclotron resonance ion source (ECR-IS), low-energy beam transport (LEBT) system, radio-frequency quadrupole (RFQ), medium-energy beam transport system, and drift tube linac. In this paper, we present the development of the LEBT system as a part of the heavy ion accelerator system, which operates from the ECR-IS to the RFQ entrance.

  8. Development of accelerator mass spectrometer based on a compact cyclotron

    NASA Astrophysics Data System (ADS)

    Kim, J.-W.; Kim, D.-G.

    2011-07-01

    A small cyclotron has been designed for accelerator mass spectrometry, and the injection beam line is constructed as part of prototyping. Mass resolution of the cyclotron is estimated to be around 4000. The design of the cyclotron was performed with orbit-tracking computations using 3D magnetic and electric fields, and beam optics of the injection line was calculated using the codes such as IGUN and TRANSPORT. The radial injection scheme is chosen to place a beam on equilibrium orbit of the cyclotron. The injection line includes an ion source, Einzel lens, rf buncher, 90° dipole magnet, and quadrupole triplet magnet. A carbon beam was extracted from the front part of the injection line. An rf cavity system for the cyclotron was built and tested. A multi channel plates (MCP) detector to measure low-current ion beams was also tested. Design considerations are given to analyzing a few different radioisotopes in form of positive ions as well as negative ions.

  9. Development of a dual layered dielectric-loaded accelerating structure.

    SciTech Connect

    Gai, W.; Liu, W.; Jing, C.; Kanareykin, A.; Antipov, S.; Nenasheva, E.; Schoessow, P.; High Energy Physics; Euclid Techlabs, LLC; Illinois Inst. of Tech.; KEK

    2008-09-01

    Due to the high magnetic field-induced surface currents on its conducting sleeve, a conventional single layer Dielectric-Loaded Accelerating (DLA) structure exhibits a relatively high RF loss. One possible way to solve this problem is to use multilayered DLA structures. In these devices, the RF power attenuation is reduced by making use of the Bragg Fiber concept: the EM fields are well confined by multiple reflections from multiple dielectric layers. This paper presents the design of an X-band dual layer DLA structure as well as the results of bench tests of the device. We will also present results on the design, numerical modeling, and fabrication of structures for coupling RF into multilayer DLAs such as a novel TM{sub 03} mode launcher and a TM{sub 01}-TM{sub 03} mode converter using dielectric-loaded corrugated waveguide.

  10. Development of a 20 MeV Dielectric-Loaded Test Accelerator

    SciTech Connect

    Gold, S.H.; Kinkead, A.K.; Gai, W.; Power, J.G.; Konecny, R.; Jing, C.; Long, J.; Tantawi, S.G.; Nantista, C.D.; Fliflet, A.W.; Lombardi, M.; Lewis, D.; Bruce, R.W.; /Unlisted

    2007-04-13

    This paper presents a progress report on a joint project by the Naval Research Laboratory (NRL) and Argonne National Laboratory (ANL), in collaboration with the Stanford Linear Accelerator Center (SLAC), to develop a dielectric-loaded test accelerator in the magnicon facility at NRL. The accelerator will be powered by an experimental 11.424-GHz magnicon amplifier that presently produces 25 MW of output power in a {approx}250-ns pulse at up to 10 Hz. The accelerator will include a 5-MeV electron injector originally developed at the Tsinghua University in Beijing, China, and can incorporate DLA structures up to 0.5 m in length. The DLA structures are being developed by ANL, and shorter test structures fabricated from a variety of dielectric materials have undergone testing at NRL at gradients up to {approx}8 MV/m. SLAC has developed components to distribute the power from the two magnicon output arms to the injector and to the DLA accelerating structure with separate control of the power ratio and relative phase. RWBruce Associates, Inc., working with NRL, has investigated means to join short ceramic sections into a continuous accelerator tube by a brazing process using an intense 83-GHz beam. The installation and testing of the first dielectric-loaded test accelerator, including injector, DLA test structure, and spectrometer, should take place within the next year.

  11. Development of a 20 MeV Dielectric-Loaded Test Accelerator

    SciTech Connect

    Gold, Steven H.; Fliflet, Arne W.; Lombardi, Marcie; Kinkead, Allen K.; Gai, Wei; Power, John G.; Konecny, Richard; Long, Jidong; Jing, Chunguang; Tantawi, Sami G.; Nantista, Christopher D.; Bruce, Ralph W.; Lewis, David III

    2006-11-27

    This paper presents a progress report on a joint project by the Naval Research Laboratory (NRL) and Argonne National Laboratory (ANL), in collaboration with the Stanford Linear Accelerator Center (SLAC), to develop a dielectric-loaded test accelerator in the magnicon facility at NRL. The accelerator will be powered by an experimental 11.424-GHz magnicon amplifier that presently produces 25 MW of output power in a {approx}250-ns pulse at up to 10 Hz. The accelerator will include a 5-MeV electron injector originally developed at the Tsinghua University in Beijing, China, and can incorporate DLA structures up to 0.5 m in length. The DLA structures are being developed by ANL, and shorter test structures fabricated from a variety of dielectric materials have undergone testing at NRL at gradients up to {approx}8 MV/m. SLAC has developed components to distribute the power from the two magnicon output arms to the injector and to the DLA accelerating structure with separate control of the power ratio and relative phase. RWBruce Associates, Inc., working with NRL, has investigated means to join short ceramic sections into a continuous accelerator tube by a brazing process using an intense 83-GHz beam. The installation and testing of the first dielectric-loaded test accelerator, including injector, DLA test structure, and spectrometer, should take place within the next year.

  12. FETAL DEXAMETHASONE EXPOSURE ACCELERATES DEVELOPMENT OF RENAL FUNCTION: RELATIONSHIP TO DOSE, CELL DIFFERENTIATION AND GROWTH INHIBITION

    EPA Science Inventory

    Fetal exposure to high doses of glucocorticoids slows cellular development and impairs organ performance, in association with growth retardation. evertheless, low doses of glucocorticoids may enhance cell differentiation and accelerate specific functions. he current study examine...

  13. NASA - 77M prototype hall thruster built under the High Voltage Hall accelerator development project

    NASA Technical Reports Server (NTRS)

    2005-01-01

    NASA - 77M prototype hall thruster built under the High Voltage Hall accelerator development project funded by the Science Mission Directorate ; potential use is propulsion for deep space science missions

  14. Development of High Power Vacuum Tubes for Accelerators and Plasma Heating

    NASA Astrophysics Data System (ADS)

    Srivastava, Vishnu

    2012-11-01

    High pulsed power magnetrons and klystrons for medical and industrial accelerators, and high CW power klystrons and gyrotrons for plasma heating in tokamak, are being developed at CEERI. S-band 2.0MW pulsed tunable magnetrons of centre frequency 2856MHz and 2998 MHz were developed, and S-band 2.6MW pulsed tunable magnetron is being developed for medical LINAC, and 3MW pulsed tunable magnetron is being developed for industrial accelerator. S-band (2856MHz), 5MW pulsed klystron was developed for particle accelerator, and S-band 6MW pulsed klystron is under development for 10MeV industrial accelerator. 350MHz, 100kW (CW) klystron is being developed for proton accelerator, and C-band 250kW (CW) klystron is being developed for plasma heating. 42GHz, 200kW (CW/Long pulse) gyrotron is under development for plasma heating. Plasma filled tubes are also being developed for switching. 25kV/1kA and 40kV/3kA thyratrons were developed for high voltage high current switching in pulse modulators for magnetrons and klystrons. 25kV/3kA Pseudospark switch of current rise time of 1kA/|a-sec and pulse repetition rate of 500Hz is being developed. Plasma assisted high power microwave device is also being investigated.

  15. EuCARD2: enhanced accelerator research and development in Europe

    NASA Astrophysics Data System (ADS)

    Romaniuk, Ryszard S.

    2013-10-01

    Accelerator science and technology is one of a key enablers of the developments in the particle physic, photon physics and also applications in medicine and industry. EuCARD2 is an European research project which will be realized during 2013-2017 inside the EC FP7 framework. The project concerns the development and coordination of European Accelerator Research and Development. The project is particularly important, to a number of domestic laboratories, due to some plans to build large accelerator infrastructure in Poland. Large accelerator infrastructure of fundamental and applied research character stimulates around it the development and industrial applications as well as biomedical of advanced accelerators, material research and engineering, cryo-technology, mechatronics, robotics, and in particular electronics - like networked measurement and control systems, sensors, computer systems, automation and control systems. The paper presents a digest of the European project EuCARD2 which is Enhanced European Coordination for Accelerator Research and Development. The paper presents a digest of the research results and assumptions in the domain of accelerator science and technology in Europe, shown during the final fourth annual meeting of the EuCARD - European Coordination of Accelerator R&D, and the kick-off meeting of the EuCARD2. There are debated a few basic groups of accelerator systems components like: measurement - control networks of large geometrical extent, multichannel systems for large amounts of metrological data acquisition, precision photonic networks of reference time, frequency and phase distribution, high field magnets, superconducting cavities, novel beam collimators, etc. The paper bases on the following materials: Internet and Intranet documents combined with EuCARD2, Description of Work FP7 EuCARD-2 DoW-312453, 2013-02-13, and discussions and preparatory materials worked on by Eucard-2 initiators.

  16. Development of a Compact Dielectric-Loaded Test Accelerator at 11.4 GHz

    SciTech Connect

    Gold, S. H.; Fliflet, A. W.; Kinkead, A. K.; Gai, W.; Power, J. G.; Konecny, R.; Jing, C.

    2009-01-22

    This paper presents a progress report on the development of a dielectric-loaded test accelerator in the Magnicon Facility at the Naval Research Laboratory (NRL). The accelerator will be powered by an 11.4-GHz magnicon amplifier that provides up to 25 MW of output power in a {approx}250-ns pulse at up to 10 Hz. The accelerator includes a 5-MeV electron injector originally developed at the Tsinghua University in Beijing, China, and can incorporate dielectric-loaded accelerating (DLA) structures of up to 0.5 m in length. The DLA structures are being developed by Argonne National Laboratory and Euclid Techlabs, and shorter test structures fabricated from a variety of dielectric materials have undergone rf testing at NRL at accelerating gradients up to 15 MV/m. The first stage of the accelerator, including the 5-MeV injector, has recently begun operation, and initial operation of the complete dielectric-loaded test accelerator, including injector, DLA test structure, and spectrometer, should take place within the next year.

  17. Group living accelerates bed bug (Hemiptera: Cimicidae) development.

    PubMed

    Saenz, Virna L; Santangelo, Richard G; Vargo, Edward L; Schal, Coby

    2014-01-01

    For many insect species, group living provides physiological and behavioral benefits, including faster development. Bed bugs (Cimex lectularius L.) live in aggregations composed of eggs, nymphs, and adults of various ages. Our aim was to determine whether bed bug nymphs reared in groups develop faster than solitary nymphs. We reared first instars either in isolation or in groups from hatching to adult emergence and recorded their development time. In addition, we investigated the effects of group housing on same-age nymphs versus nymphs reared with adults. Nymphal development was 2.2 d faster in grouped nymphs than in solitary-housed nymphs, representing 7.3% faster overall development. However, this grouping effect did not appear to be influenced by group composition. Thus, similar to other gregarious insect species, nymph development in bed bugs is faster in aggregations than in isolation. PMID:24605482

  18. Developments in laser wakefield accelerators: From single-stage to two-stage

    NASA Astrophysics Data System (ADS)

    Li, Wen-Tao; Wang, Wen-Tao; Liu, Jian-Sheng; Wang, Cheng; Zhang, Zhi-Jun; Qi, Rong; Yu, Chang-Hai; Li, Ru-Xin; Xu, Zhi-Zhan

    2015-01-01

    Laser wakefield accelerators (LWFAs) are compact accelerators which can produce femtosecond high-energy electron beams on a much smaller scale than the conventional radiofrequency accelerators. It is attributed to their high acceleration gradient which is about 3 orders of magnitude larger than the traditional ones. The past decade has witnessed the major breakthroughs and progress in developing the laser wakfield accelerators. To achieve the LWFAs suitable for applications, more and more attention has been paid to optimize the LWFAs for high-quality electron beams. A single-staged LWFA does not favor generating controllable electron beams beyond 1 GeV since electron injection and acceleration are coupled and cannot be independently controlled. Staged LWFAs provide a promising route to overcome this disadvantage by decoupling injection from acceleration and thus the electron-beam quality as well as the stability can be greatly improved. This paper provides an overview of the physical conceptions of the LWFA, as well as the major breakthroughs and progress in developing LWFAs from single-stage to two-stage LWFAs. Project supported by the National Natural Science Foundation of China (Grant Nos. 11127901, 11425418, and 61221064), the National Basic Research Program of China (Grant No. 2011CB808100), and the Science and Technology Talent Project of Shanghai City, China (Grant Nos. 12XD1405200 and 12ZR1451700).

  19. Accelerating NASA GN&C Flight Software Development

    NASA Technical Reports Server (NTRS)

    Tamblyn, Scott; Henry, Joel; Rapp, John

    2010-01-01

    When the guidance, navigation, and control (GN&C) system for the Orion crew vehicle undergoes Critical Design Review (CDR), more than 90% of the flight software will already be developed - a first for NASA on a project of this scope and complexity. This achievement is due in large part to a new development approach using Model-Based Design.

  20. Poster Sessions. [Concurrent Poster Session at AHRD Annual Conference, 2000.

    ERIC Educational Resources Information Center

    2000

    This document contains presentations from four poster sessions at a conference on human resource development (HRD). "Human Resource and Organization Development Program Brochures: What Prospective Students Want" (Rose Opengart, Mary Wilson Callahan) reports on a study of promotional materials of graduate programs in the field of human resource and…

  1. Latest Development in Superconducting RF Structures for beta=1 Particle Acceleration

    SciTech Connect

    Peter Kneisel

    2006-06-26

    Superconducting RF technology is since nearly a decade routinely applied to different kinds of accelerating devices: linear accelerators, storage rings, synchrotron light sources and FEL's. With the technology recommendation for the International Linear Collider (ILC) a year ago, new emphasis has been placed on improving the performance of accelerating cavities both in Q-value and in accelerating gradients with the goal to achieve performance levels close to the fundamental limits given by the material parameters of the choice material, niobium. This paper will summarize the challenges to SRF technology and will review the latest developments in superconducting structure design. Additionally, it will give an overview of the newest results and will report on the developments in alternative materials and technologies.

  2. Sustainable Energy in Remote Indonesian Grids. Accelerating Project Development

    SciTech Connect

    Hirsch, Brian; Burman, Kari; Davidson, Carolyn; Elchinger, Michael; Hardison, R.; Karsiwulan, D.; Castermans, B.

    2015-06-30

    Sustainable Energy for Remote Indonesian Grids (SERIG) is a U.S. Department of Energy (DOE) funded initiative to support Indonesia’s efforts to develop clean energy and increase access to electricity in remote locations throughout the country. With DOE support, the SERIG implementation team consists of the National Renewable Energy Laboratory (NREL) and Winrock International’s Jakarta, Indonesia office. Through technical assistance that includes techno-economic feasibility evaluation for selected projects, government-to-government coordination, infrastructure assessment, stakeholder outreach, and policy analysis, SERIG seeks to provide opportunities for individual project development and a collective framework for national replication office.

  3. Fast Track Teaching: Beginning the Experiment in Accelerated Leadership Development

    ERIC Educational Resources Information Center

    Churches, Richard; Hutchinson, Geraldine; Jones, Jeff

    2009-01-01

    This article provides an overview of the development of the Fast Track teaching programme and personalised nature of the training and support that has been delivered. Fast Track teacher promotion rates are compared to national statistics demonstrating significant progression for certain groups, particularly women. (Contains 3 tables and 3 figures.)

  4. Development of polarized ion source for the JINR accelerator complex

    NASA Astrophysics Data System (ADS)

    Fimushkin, V. V.; Kovalenko, A. D.; Kutuzova, L. V.; Prokofichev, Yu V.; Shutov, B.; Belov, A. S.; Zubets, V. N.; Turbabin, A. V.

    2016-02-01

    Status of the JINR polarized ion source development is described. The source is under tests at the test-bench of LHEP, JINR. A charge-exchange plasma ionizer has been tested initially without a storage cell in the ionization region. An unpolarized deuterium ion beam with peak current of 160 mA, 23 keV energy, pulse duration of 100 μs and repetition rate of 1 Hz has been extracted from the ionizer. With a free polarized atomic hydrogen beam injected into the ionizer a polarized proton beam with peak current of 1.4 mA has been obtained. The nearest plans for the source development include tests of the ionizer with the storage cell and tuning of the high frequency transition units installed in their operating position with a Breit-Rabi polarimeter.

  5. Computational Tools for Accelerating Carbon Capture Process Development

    SciTech Connect

    Miller, David

    2013-01-01

    The goals of the work reported are: to develop new computational tools and models to enable industry to more rapidly develop and deploy new advanced energy technologies; to demonstrate the capabilities of the CCSI Toolset on non-proprietary case studies; and to deploy the CCSI Toolset to industry. Challenges of simulating carbon capture (and other) processes include: dealing with multiple scales (particle, device, and whole process scales); integration across scales; verification, validation, and uncertainty; and decision support. The tools cover: risk analysis and decision making; validated, high-fidelity CFD; high-resolution filtered sub-models; process design and optimization tools; advanced process control and dynamics; process models; basic data sub-models; and cross-cutting integration tools.

  6. Project development teams: a novel mechanism for accelerating translational research.

    PubMed

    Sajdyk, Tammy J; Sors, Thomas G; Hunt, Joe D; Murray, Mary E; Deford, Melanie E; Shekhar, Anantha; Denne, Scott C

    2015-01-01

    The trend in conducting successful biomedical research is shifting from individual academic labs to coordinated collaborative research teams. Teams of experienced investigators with a wide variety of expertise are now critical for developing and maintaining a successful, productive research program. However, assembling a team whose members have the right expertise requires a great deal of time and many resources. To assist investigators seeking such resources, the Indiana Clinical and Translational Sciences Institute (Indiana CTSI) created the Project Development Teams (PDTs) program to support translational research on and across the Indiana University-Purdue University Indianapolis, Indiana University, Purdue University, and University of Notre Dame campuses. PDTs are multidisciplinary committees of seasoned researchers who assist investigators, at any stage of research, in transforming ideas/hypotheses into well-designed translational research projects. The teams help investigators capitalize on Indiana CTSI resources by providing investigators with, as needed, mentoring and career development; protocol development; pilot funding; institutional review board, regulatory, and/or nursing support; intellectual property support; access to institutional technology; and assistance with biostatistics, bioethics, recruiting participants, data mining, engaging community health, and collaborating with other investigators.Indiana CTSI leaders have analyzed metrics, collected since the inception of the PDT program in 2008 from both investigators and team members, and found evidence strongly suggesting that the highly responsive teams have become an important one-stop venue for facilitating productive interactions between basic and clinical scientists across four campuses, have aided in advancing the careers of junior faculty, and have helped investigators successfully obtain external funds. PMID:25319172

  7. Photoneutron target development for the RPI linear accelerator

    NASA Astrophysics Data System (ADS)

    Overberg, M. E.; Moretti, B. E.; Slovacek, R. E.; Block, R. C.

    1999-12-01

    Two new photoneutron targets have been developed for neutron time-of-flight experiments, the axial water-moderated target (AWMT) and the bare bounce target (BBT). These targets operate without any lead shielding nearby and both have superior neutron resolution compared to the older bounce target. The BBT has been selected over the AWMT for general time-of-flight measurements because it exhibited lower neutron background in the keV energy region.

  8. Accelerated field facility development for hot sour gas

    SciTech Connect

    Kuntz, L.K.

    1983-10-01

    This paper presents the chronological plan by which a grass roots sweetening facility was constructed in a minimum amount of time. The facility design was based on production with 9% carbon dioxide and 40 ppm hydrogen sulfide. Flowing wellhead temperatures were predicted to be approximately 300/sup 0/F with flowing wellhead pressures to 11,500 psi. The production facility, with a current total nominal capacity of 100 MMcf/D, was installed as five separate parallel sweetening units. The units were put on-stream in phases in order to maintain a sweetening capacity schedule compatible with wells being put on production. The first units were available for service in three months. All five units were complete in nine months, and a permanent facility installation was commissioned three months later. The process design, equipment procurement, and installation phases of the project were pursued concurrently. Three different sweetening systems were operated during the facility development. A conventional DEA (diethanolamine) system was used because of its simple operation. Conversions were made to a proprietary MDEA (methyldiethanolamine) system in order to increase capacity. A proprietary activated MDEA was tested and operated in order to determine sweetening system selection for future facility capacity and for other applications. Included is a discussion of the project development procedure and key considerations that led to minimal development time. General comparisons are made concerning the performance of several sweetening systems.

  9. Using pattern enumeration to accelerate process development and ramp yield

    NASA Astrophysics Data System (ADS)

    Zhuang, Linda; Pang, Jenny; Xu, Jessy; Tsai, Mengfeng; Wang, Amy; Zhang, Yifan; Sweis, Jason; Lai, Ya-Chieh; Ding, Hua

    2016-03-01

    During a new technology node process setup phase, foundries do not initially have enough product chip designs to conduct exhaustive process development. Different operational teams use manually designed simple test keys to set up their process flows and recipes. When the very first version of the design rule manual (DRM) is ready, foundries enter the process development phase where new experiment design data is manually created based on these design rules. However, these IP/test keys contain very uniform or simple design structures. This kind of design normally does not contain critical design structures or process unfriendly design patterns that pass design rule checks but are found to be less manufacturable. It is desired to have a method to generate exhaustive test patterns allowed by design rules at development stage to verify the gap of design rule and process. This paper presents a novel method of how to generate test key patterns which contain known problematic patterns as well as any constructs which designers could possibly draw based on current design rules. The enumerated test key patterns will contain the most critical design structures which are allowed by any particular design rule. A layout profiling method is used to do design chip analysis in order to find potential weak points on new incoming products so fab can take preemptive action to avoid yield loss. It can be achieved by comparing different products and leveraging the knowledge learned from previous manufactured chips to find possible yield detractors.

  10. Advanced low-beta cavity development for proton and ion accelerators

    NASA Astrophysics Data System (ADS)

    Conway, Z. A.; Kelly, M. P.; Ostroumov, P. N.

    2015-05-01

    Recent developments in designing and processing low-beta superconducting cavities at Argonne National Laboratory are very encouraging for future applications requiring compact proton and ion accelerators. One of the major benefits of these accelerating structures is achieving real-estate accelerating gradients greater than 3 MV/m very efficiently either continuously or for long-duty cycle operation (>1%). The technology has been implemented in low-beta accelerator cryomodules for the Argonne ATLAS heavy-ion linac where the cryomodules are required to have real-estate gradients of more than 3 MV/m. In offline testing low-beta cavities with even higher gradients have already been achieved. This paper will review this work where we have achieved surface fields greater than 166 mT magnetic and 117 MV/m electric in a 72 MHz quarter-wave resonator optimized for β = 0.077 ions.

  11. Development of a 10 MW, 91 GHz gyroklystron for accelerator applications

    NASA Astrophysics Data System (ADS)

    Ives, R. Lawrence; Lawson, Wes; Neilson, Jeff M.; Read, Michael

    2001-05-01

    A 10 MW, 91 GHz gyroklystron is under development for W-Band accelerator applications. The device will generate 1.5 microsecond pulses at 120 Hz and will be provided to Stanford Linear Accelerator Center for testing of W-Band accelerator components and subsystems. A magnetron injection gun operating at 500 kV will provide a 55 amp beam for interaction in a 5 cavity circuit. The output will be in a hybrid TE01/TE02 mode that can be converted to a more suitable mode at the accelerator. The device is expected to operate with efficiency close to 40% with a gain of 55 dB. A depressed collector will be implemented to allow improvement in the total efficiency to more than 50%.

  12. Development of repetitive railgun pellet accelerator and steady-state pellet supply system

    SciTech Connect

    Oda, Y.; Onozuka, M.; Azuma, K.; Kasai, S.; Hasegawa, K.

    1995-12-31

    A railgun system for repetitive high-speed pellet acceleration and steady-state pellet supply system has been developed and investigated. Using a 2m-long railgun system, the hydrogen pellet was accelerated to 2.6km/sec by the supplied energy of 1.7kJ. It is expected that the hydrogen pellet can be accelerated to 3km/sec using the present pneumatic pellet accelerator and a 2m-long augment railgun. Screw-driven hydrogen-isotope filament extruding system has been fabricated and will be tested to examine its applicability to the steady-state extrusion of the solid hydrogen-isotope filament.

  13. Compact Dielectric Wall Accelerator Development For Intensity Modulated Proton Therapy And Homeland Security Applications

    SciTech Connect

    Chen, Y -; Caporaso, G J; Guethlein, G; Sampayan, S; Akana, G; Anaya, R; Blackfield, D; Cook, E; Falabella, S; Gower, E; Harris, J; Hawkins, S; Hickman, B; Holmes, C; Horner, A; Nelson, S; Paul, A; Pearson, D; Poole, B; Richardson, R; Sanders, D; Stanley, J; Sullivan, J; Wang, L; Watson, J; Weir, J

    2009-06-17

    Compact dielectric wall (DWA) accelerator technology is being developed at the Lawrence Livermore National Laboratory. The DWA accelerator uses fast switched high voltage transmission lines to generate pulsed electric fields on the inside of a high gradient insulating (HGI) acceleration tube. Its high electric field gradients are achieved by the use of alternating insulators and conductors and short pulse times. The DWA concept can be applied to accelerate charge particle beams with any charge to mass ratio and energy. Based on the DWA system, a novel compact proton therapy accelerator is being developed. This proton therapy system will produce individual pulses that can be varied in intensity, energy and spot width. The system will be capable of being sited in a conventional linac vault and provide intensity modulated rotational therapy. The status of the developmental new technologies that make the compact system possible will be reviewed. These include, high gradient vacuum insulators, solid dielectric materials, SiC photoconductive switches and compact proton sources. Applications of the DWA accelerator to problems in homeland security will also be discussed.

  14. Pre-Implementation and Performance Plan for the Latino Development and Technology Accelerator Center

    SciTech Connect

    Quiroga, Marcelo

    2007-03-30

    This report discusses the Latino Development and Technology Accelerator Center (Center) and its innovative economic development program. The chapters describe the organization and the operations of a two-pillar model for training and business acceleration and how the program focuses on the economic development of a disadvantaged Chicago, Illinois, Hispanic community located in Humboldt Park. The Humboldt Park community is located 3 miles west of Chicago's affluent downtown. Humboldt Park residents have income levels below the poverty line and unemployment rates twice the national average.

  15. Accelerating materials discovery through the development of polymer databases

    NASA Astrophysics Data System (ADS)

    Audus, Debra

    In our line of business we create chemical solutions for a wide range of applications, such as home and personal care, printing and packaging, automotive and structural coatings, and structural plastics and foams applications. In this environment, stable and highly automated workflows suitable to handle complex systems are a must. By satisfying these prerequisites, efficiency for the development of new materials can be significantly improved by combining modeling and experimental approaches. This is in fact in line with recent Materials Genome Initiative efforts sponsored by the US administration. From our experience, we know, that valuable contributions to product development are possible today by combining existing modeling techniques in an intelligent fashion, provided modeling and experiment work closely together. In my presentation I intend to review approaches to build and parameterize soft matter systems. As an example of our standard workflow, I will show a few applications, which include the design of a stabilizer molecule for dispersing polymer particles and the simulation of polystyrene dispersions.

  16. Development of accelerator radiation protection at the SSC

    SciTech Connect

    Toohig, T.

    1993-11-01

    The design of the Superconducting Super Collider evolved over a series of studies from 1984 to 1989. Considerations of concentration of radiation sources and provisions for operational control and monitoring of radiation were determining elements in the design concepts for the facility. The development of the designs involved an extension of the range of applicability of energy deposition and radiation shielding codes beyond the 3 TeV level of the proposed UNK collider to 20 TeV for single beam effects and to 40 TeV in the collision regions. This extrapolation was complicated by the newly discovered, very energetic muons from short-lived states associated with heavy quark states. The design guideline for radiation protection was specified to be 10 mRem/yr, 10% of the Federal limit. In order to limit the amount of land required for the facility, which would extend over some 250 mi. sq., the configuration of the land to be acquired was tailored to the requirements for radiation containment below the levels of the guideline.

  17. Accelerating development of a predictive science of climate.

    SciTech Connect

    Drake, John B; Jones, Phil

    2007-01-01

    Climate change and studies of its implications are front page news. Could the heat waves of July 2006 in Europe and the US be caused by global warming? Are increased incidences of strong tropical storms and hurricanes like Katrina to be expected? Will coastal cities be flooded due to sea level rise? The National Climatic Data Center (NCDC) which archives all weather data for the nation reports that global surface temperatures have increased at a rate near 0.6 C over the last century but that the trend is three times larger since 1976 [Easterling, 2006]. Will this rate continue or will climate change be even more abrupt? Stepping back from the flurry of questions, scientists must take a systematic approach and develop a predictive framework. With responsibility for advising on energy and technology strategies, the Department of Energy Office of Biological and Environmental Research has chosen to bolster the science of climate in order to get the story straight on the factors that cause climate change and the role of carbon loading from fossil fuel use.

  18. Synapsin IIa accelerates functional development of neuromuscular synapses.

    PubMed Central

    Schaeffer, E; Alder, J; Greengard, P; Poo, M M

    1994-01-01

    We have investigated the possible involvement of the synaptic vesicle protein synapsin IIa in synapse development. Synapsin IIa was introduced into Xenopus embryonic spinal neurons by early blastomere injection, and nerve-muscle cultures were prepared. Synaptic currents were measured by comparing synapses in which the presynaptic neuron either contained [syn IIa (+)] or lacked (control) exogenous synapsin IIa. Syn IIa (+) synapses had a 3.6-fold increase in the frequency and a 2.1-fold increase in the amplitude of spontaneous synaptic currents, compared to controls, after 2 days in culture. Synapsin IIa also increased the amplitude of evoked synaptic currents by 2.3-fold in 2-day cultures. The evoked synaptic current amplitudes of syn IIa (+) synapses had a lower coefficient of variation indicating a more stable evoked response. These enhanced synaptic activities were independent of the presence or absence of the protein in the postsynaptic muscle cell. The findings indicate a role for synapsin IIa in synapse maturation. Images PMID:8171006

  19. Noninvasive Laser Probing of Ultrashort Single Electron Bunches for Accelerator And Light Source Development

    SciTech Connect

    Bolton, P.R.; /SLAC

    2007-06-11

    Companion development of ultrafast electron beam diagnostics capable of noninvasively resolving single bunch detail is essential for the development of high energy, high brightness accelerator facilities and associated beam-based light source applications. Existing conventional accelerators can exhibit timing-jitter down to the 100 femtosecond level which exceeds their single bunch duration capability. At the other extreme, in relatively jitterless environments, laser-plasma wakefield accelerators (LWFA) can generate single electron bunches of duration estimated to be of order 10 femtoseconds making this setting a valuable testbed for development of broadband electron bunch diagnostics. Characteristics of electro-optic schemes and laser-induced reflectance are discussed with emphasis on temporal resolution.

  20. ASP Networking Sessions Summary

    NASA Astrophysics Data System (ADS)

    Bartolone, L. M.

    2008-06-01

    In response to evaluation conducted during the Annual Meeting of the Astronomical Society of the Pacific in 2006, ``Engaging the EPO Community: Best Practices, New Approaches,'' loosely structured networking sessions were added by the program committee in an effort to assist conference attendees in achieving their stated conference goals. The co-chairs of the 2007 conference invited registrants to serve as facilitators for twelve networking sessions. This work aims to summarize the conversations that took place during those sessions, based upon notes and artifacts provided to the author by the session facilitators.

  1. Collaborative workbench for cyberinfrastructure to accelerate science algorithm development

    NASA Astrophysics Data System (ADS)

    Ramachandran, R.; Maskey, M.; Kuo, K.; Lynnes, C.

    2013-12-01

    There are significant untapped resources for information and knowledge creation within the Earth Science community in the form of data, algorithms, services, analysis workflows or scripts, and the related knowledge about these resources. Despite the huge growth in social networking and collaboration platforms, these resources often reside on an investigator's workstation or laboratory and are rarely shared. A major reason for this is that there are very few scientific collaboration platforms, and those that exist typically require the use of a new set of analysis tools and paradigms to leverage the shared infrastructure. As a result, adoption of these collaborative platforms for science research is inhibited by the high cost to an individual scientist of switching from his or her own familiar environment and set of tools to a new environment and tool set. This presentation will describe an ongoing project developing an Earth Science Collaborative Workbench (CWB). The CWB approach will eliminate this barrier by augmenting a scientist's current research environment and tool set to allow him or her to easily share diverse data and algorithms. The CWB will leverage evolving technologies such as commodity computing and social networking to design an architecture for scalable collaboration that will support the emerging vision of an Earth Science Collaboratory. The CWB is being implemented on the robust and open source Eclipse framework and will be compatible with widely used scientific analysis tools such as IDL. The myScience Catalog built into CWB will capture and track metadata and provenance about data and algorithms for the researchers in a non-intrusive manner with minimal overhead. Seamless interfaces to multiple Cloud services will support sharing algorithms, data, and analysis results, as well as access to storage and computer resources. A Community Catalog will track the use of shared science artifacts and manage collaborations among researchers.

  2. The United States Particle Accelerator School: Educating the next generation of accelerator scientists and engineers

    SciTech Connect

    Barletta, William A.; /MIT

    2008-09-01

    Only a handful of universities in the US offer any formal training in accelerator science. The United States Particle Accelerator School (USPAS) is National Graduate Educational Program that has developed a highly successful educational paradigm that, over the past twenty-years, has granted more university credit in accelerator / beam science and technology than any university in the world. Sessions are held twice annually, hosted by major US research universities that approve course credit, certify the USPAS faculty, and grant course credit. The USPAS paradigm is readily extensible to other rapidly developing, crossdisciplinary research areas such as high energy density physics.

  3. The United States Particle Accelerator School: Educating the Next Generation of Accelerator Scientists and Engineers

    SciTech Connect

    Barletta, William A.

    2009-03-10

    Only a handful of universities in the US offer any formal training in accelerator science. The United States Particle Accelerator School (USPAS) is National Graduate Educational Program that has developed a highly successful educational paradigm that, over the past twenty-years, has granted more university credit in accelerator/beam science and technology than any university in the world. Sessions are held twice annually, hosted by major US research universities that approve course credit, certify the USPAS faculty, and grant course credit. The USPAS paradigm is readily extensible to other rapidly developing, cross-disciplinary research areas such as high energy density physics.

  4. The United States Particle Accelerator School: Educating the Next Generation of Accelerator Scientists and Engineers

    NASA Astrophysics Data System (ADS)

    Barletta, William A.

    2009-03-01

    Only a handful of universities in the US offer any formal training in accelerator science. The United States Particle Accelerator School (USPAS) is National Graduate Educational Program that has developed a highly successful educational paradigm that, over the past twenty-years, has granted more university credit in accelerator/beam science and technology than any university in the world. Sessions are held twice annually, hosted by major US research universities that approve course credit, certify the USPAS faculty, and grant course credit. The USPAS paradigm is readily extensible to other rapidly developing, cross-disciplinary research areas such as high energy density physics.

  5. Residual acceleration data on IML-1: Development of a data reduction and dissemination plan

    NASA Technical Reports Server (NTRS)

    Rogers, Melissa J. B.; Alexander, J. Iwan D.; Wolf, Randy

    1992-01-01

    The main thrust of our work in the third year of contract NAG8-759 was the development and analysis of various data processing techniques that may be applicable to residual acceleration data. Our goal is the development of a data processing guide that low gravity principal investigators can use to assess their need for accelerometer data and then formulate an acceleration data analysis strategy. The work focused on the flight of the first International Microgravity Laboratory (IML-1) mission. We are also developing a data base management system to handle large quantities of residual acceleration data. This type of system should be an integral tool in the detailed analysis of accelerometer data. The system will manage a large graphics data base in the support of supervised and unsupervised pattern recognition. The goal of the pattern recognition phase is to identify specific classes of accelerations so that these classes can be easily recognized in any data base. The data base management system is being tested on the Spacelab 3 (SL3) residual acceleration data.

  6. The MIT Accelerator Laboratory for Diagnostic Development for OMEGA, Z and the NIF

    NASA Astrophysics Data System (ADS)

    Petrasso, R.; Gatu Johnson, M.; Armstrong, E.; Orozco, D.; Rinderknecht, H. G.; Rojas Herrera, J.; Rosenberg, M.; Sio, H.; Zylstra, A.; Frenje, J.; Li, C. K.; Seguin, F. H.; Hahn, K.; Jones, B.; Ruiz, C. L.; Sangster, T. C.

    2014-10-01

    The MIT Linear Electrostatic Ion Accelerator generates D-D and D-3He fusion products, which are used for development of nuclear diagnostics for OMEGA, Z, and the NIF. Fusion reaction rates around 106 s-1 are routinely achieved with this accelerator, and fluence and energy of the fusion products are accurately characterized. Diagnostics developed and calibrated at this facility include CR-39 based charged-particle spectrometers, neutron detectors, and the particle Time-Of-Flight (pTOF) CVD-diamond-based bang time detector. The accelerator is also a vital tool in the education of graduate and undergraduate students at MIT. This work was supported in part by SNL, DOE, LLE and LLNL.

  7. Development of and flight results from the Space Acceleration Measurement System (SAMS)

    NASA Technical Reports Server (NTRS)

    Delombard, Richard; Finley, Brian D.; Baugher, Charles R.

    1992-01-01

    Described here is the development of and the flight results from the Space Acceleration Measurement System (SAMS) flight units used in the Orbiter middeck, Spacelab module, and the Orbitercargo bay. The SAMS units are general purpose microgravity accelerometers designed to support a variety of science experiments with microgravity acceleration measurements. A total of six flight units have been fabricated; four for use in the Orbiter middeck and Spacelab module, and two for use in the Orbiter cargo bay. The design of the units is briefly described. The initial two flights of SAMS units on STS-40 (June 1991) and STS-43 (August 1991) resulted in 371 megabytes and 2.6 gigabytes of data respectively. Analytical techniques developed to examine this quantity of acceleration data are described and sample plots of analyzed data are illustrated. Future missions for the SAMS units are listed.

  8. 78 FR 61321 - Board of Directors Executive Session Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-03

    ...; ] AFRICAN DEVELOPMENT FOUNDATION Board of Directors Executive Session Meeting Meeting: African Development Foundation, Board of Directors Executive Session Meeting Time: Tuesday, October 22, 2013 9:00 a.m. to 1:00...

  9. 77 FR 62211 - Board of Directors Executive Session Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-12

    ...; ] AFRICAN DEVELOPMENT FOUNDATION Board of Directors Executive Session Meeting Meeting: African Development Foundation, Board of Directors Executive Session Meeting. Time: Tuesday, October 23, 2012, 8:30 a.m. to...

  10. 78 FR 5164 - Board of Directors Executive Session Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-24

    ...; ] AFRICAN DEVELOPMENT FOUNDATION Board of Directors Executive Session Meeting Meeting: African Development Foundation, Board of Directors Executive Session Meeting Time: Tuesday, February 5, 2013, 9:00 a.m. to 1:00...

  11. 78 FR 46312 - Board of Directors Executive Session Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-31

    ...; ] AFRICAN DEVELOPMENT FOUNDATION Board of Directors Executive Session Meeting Meeting: African Development Foundation, Board of Directors Executive Session Meeting Time: Tuesday, August 6, 2013 8:30 a.m. to 1:00...

  12. The Public Poster Session

    ERIC Educational Resources Information Center

    Levine-Rasky, Cynthia

    2009-01-01

    This note describes the use of a student poster session as an innovative approach to student learning. The local context for the assignment is provided, followed by a description of the course for which the poster was prepared, details about the assignment including its evaluation, and practical considerations for planning a poster session. The…

  13. A Radical Poster Session.

    ERIC Educational Resources Information Center

    Gore, Paul A., Jr.; Camp, Cameron J.

    1987-01-01

    Presents the use of a poster session as an integral part of an experimental design course. Describes how the principles of experimental design are demonstrated when undergraduates design and conduct original experiments, using radishes as subjects, and present their results in a poster session. Discusses the benefits of using radishes as subjects.…

  14. Temporal Development of Auroral Acceleration Potentials: High-Altitude Evolutionary Sequences, Drivers and Consequences

    NASA Astrophysics Data System (ADS)

    Hull, A. J.; Wilber, M.; Chaston, C.; Bonnell, J.; Mozer, F.; McFadden, J.; Goldstein, M.; Fillingim, M.

    2007-12-01

    The region above the auroral acceleration region is an integral part of the auroral zone electrodynamic system. At these altitudes (≥ 3 Re) we find the source plasma and fields that determine acceleration processes occurring at lower altitudes, which play a key role in the transport of mass and energy into the ionosphere. Dynamic changes in these high-altitude regions can affect and/or control lower-altitude acceleration processes according to how field-aligned currents and specific plasma sources form and decay and how they are spatially distributed, and through magnetic configuration changes deeper in the magnetotail. Though much progress has been made, the time development and consequential effects of the high-altitude plasma and fields are still not fully understood. We present Cluster multi-point observations at key instances within and above the acceleration region (> 3 RE) of evolving auroral arc current systems. Results are presented from events occurring under different conditions, such as magnetospheric activity, associations with density depletions or gradients, and Alfvenic turbulence. A preliminary survey, primarily at or near the plasma sheet boundary, indicates quasi- static up-down current pair systems are at times associated with density depletions and other instances occur in association with density gradients. The data suggest that such quasi-static current systems may be evolving from structured Alfvenic current systems. We will discuss the temporal development of auroral acceleration potentials, plasma and currents, including quasi-static system formation from turbulent systems of structured Alfvenic field-aligned currents, density depletion and constituent reorganization of the source and ionospheric plasma that transpire in such systems. Of particular emphasis is how temporal changes in magnetospheric source plasma and fields affect the development of auroral acceleration potentials at lower altitudes.

  15. Methoprene and protein supplements accelerate reproductive development and improve mating success of male tephritid flies

    Technology Transfer Automated Retrieval System (TEKTRAN)

    We have been studying the physiological mechanisms responsible for coordination of reproductive maturity and sex pheromone communication in males of tephritid flies in order to develop methods for acceleration of reproductive maturity among sterilized males. Our studies revealed that the juvenile ho...

  16. Future Development Of The Flerov Laboratory Accelerator Complex (Project DRIBs-III)

    NASA Astrophysics Data System (ADS)

    Gulbekian, G. G.; Dmitriev, S. N.; Itkis, M. G.; Oganessian, Yu. Ts.; Popeko, A. G.

    2010-04-01

    Future development of the FLNR accelerator complex (project DRIBs-III) includes modernization of existing cyclotrons, construction of a new experimental hall, creation of a new high current cyclotron and of next generation experimental set-ups. Realization of the project is planned for 2010-2016.

  17. Accelerating the Early Numeracy Development of Kindergartners with Limited Working Memory Skills through Remedial Education

    ERIC Educational Resources Information Center

    Toll, Sylke W. M.; Van Luit, Johannes E. H.

    2013-01-01

    Background: Young children with limited working memory skills are a special interest group among all children that score below average on early numeracy tests. This study examines the effect of accelerating the early numeracy development of these children through remedial education, by comparing them with children with typically working memory…

  18. Accelerated Professional Development and Peer Consultation: Two Strategies for Continuing Professional Education for Nurses.

    ERIC Educational Resources Information Center

    Hart, Gail; Clinton, Michael; Edwards, Helen; Evans, Katie; Lunney, Paul; Posner, Natasha; Tooth, Barbara; Weir, Derek; Ryan, Yoni

    2000-01-01

    A comparison was made of accelerated professional development (APD) for nurses (n=64), involving peer consultation and reflective practice, and peer consultation alone (n=30). Although APD participants had a higher completion rate, improvements in caregiver behaviors and work environment were not significantly different. (SK)

  19. Accelerating the Development of Expertise: A Step-Change in Social Science Research Capacity Building

    ERIC Educational Resources Information Center

    Wray, Alison; Wallace, Mike

    2011-01-01

    It is argued that future research capacity building for the social sciences needs to incorporate methods to accelerate the acquisition by researchers of holistic expertise relevant to their roles as researchers and as developers of others. An agenda is presented, based on a model of learning that highlights missing elements of current provision,…

  20. 1971 AERA Research Training Sessions. Final Report.

    ERIC Educational Resources Information Center

    Byers, Joe L.

    This is a report of a 5-day research training session held in New York City from January 30 to February 3, 1971 under the sponsorship of the American Educational Research Association (AERA) with support from the U.S. Office of Education. The purpose of the training session was to develop and improve research competencies of individuals engaged in…

  1. Helicon Plasma Injector and Ion Cyclotron Acceleration Development in the VASIMR Experiment

    NASA Technical Reports Server (NTRS)

    Squire, Jared P.; Chang, Franklin R.; Jacobson, Verlin T.; McCaskill, Greg E.; Bengtson, Roger D.; Goulding, Richard H.

    2000-01-01

    In the Variable Specific Impulse Magnetoplasma Rocket (VASIMR) radio frequency (rf) waves both produce the plasma and then accelerate the ions. The plasma production is done by action of helicon waves. These waves are circular polarized waves in the direction of the electron gyromotion. The ion acceleration is performed by ion cyclotron resonant frequency (ICRF) acceleration. The Advanced Space Propulsion Laboratory (ASPL) is actively developing efficient helicon plasma production and ICRF acceleration. The VASIMR experimental device at the ASPL is called VX-10. It is configured to demonstrate the plasma production and acceleration at the 10kW level to support a space flight demonstration design. The VX-10 consists of three electromagnets integrated into a vacuum chamber that produce magnetic fields up to 0.5 Tesla. Magnetic field shaping is achieved by independent magnet current control and placement of the magnets. We have generated both helium and hydrogen high density (>10(exp 18) cu m) discharges with the helicon source. ICRF experiments are underway. This paper describes the VX-10 device, presents recent results and discusses future plans.

  2. DEVELOPING THE PHYSICS DESIGN FOR NDCX-II, A UNIQUE PULSE-COMPRESSING ION ACCELERATOR

    SciTech Connect

    Friedman, A.; Barnard, J. J.; Cohen, R. H.; Grote, D. P.; Lund, S. M.; Sharp, W. M.; Faltens, A.; Henestroza, E.; Jung, J-Y.; Kwan, J. W.; Lee, E. P.; Leitner, M. A.; Logan, B. G.; Vay, J.-L.; Waldron, W. L.; Davidson, R.C.; Dorf, M.; Gilson, E.P.; Kaganovich, I.

    2009-07-20

    The Heavy Ion Fusion Science Virtual National Laboratory(a collaboration of LBNL, LLNL, and PPPL) is using intense ion beams to heat thin foils to the"warm dense matter" regime at<~;; 1 eV, and is developing capabilities for studying target physics relevant to ion-driven inertial fusion energy. The need for rapid target heating led to the development of plasma-neutralized pulse compression, with current amplification factors exceeding 50 now routine on the Neutralized Drift Compression Experiment (NDCX). Construction of an improved platform, NDCX-II, has begun at LBNL with planned completion in 2012. Using refurbished induction cells from the Advanced Test Accelerator at LLNL, NDCX-II will compress a ~;;500 ns pulse of Li+ ions to ~;;1 ns while accelerating it to 3-4 MeV over ~;;15 m. Strong space charge forces are incorporated into the machine design at a fundamental level. We are using analysis, an interactive 1D PIC code (ASP) with optimizing capabilities and centroid tracking, and multi-dimensional Warpcode PIC simulations, to develop the NDCX-II accelerator. This paper describes the computational models employed, and the resulting physics design for the accelerator.

  3. Accelerated stress testing of thin film solar cells: Development of test methods and preliminary results

    NASA Technical Reports Server (NTRS)

    Lathrop, J. W.

    1985-01-01

    If thin film cells are to be considered a viable option for terrestrial power generation their reliability attributes will need to be explored and confidence in their stability obtained through accelerated testing. Development of a thin film accelerated test program will be more difficult than was the case for crystalline cells because of the monolithic construction nature of the cells. Specially constructed test samples will need to be fabricated, requiring committment to the concept of accelerated testing by the manufacturers. A new test schedule appropriate to thin film cells will need to be developed which will be different from that used in connection with crystalline cells. Preliminary work has been started to seek thin film schedule variations to two of the simplest tests: unbiased temperature and unbiased temperature humidity. Still to be examined are tests which involve the passage of current during temperature and/or humidity stress, either by biasing in the forward (or reverse) directions or by the application of light during stress. Investigation of these current (voltage) accelerated tests will involve development of methods of reliably contacting the thin conductive films during stress.

  4. Developing The Physics Desing for NDCS-II, A Unique Pulse-Compressing Ion Accelerator

    SciTech Connect

    Friedman, A; Barnard, J J; Cohen, R H; Grote, D P; Lund, S M; Sharp, W M; Faltens, A; Henestroza, E; Jung, J; Kwan, J W; Lee, E P; Leitner, M A; Logan, B G; Vay, J -; Waldron, W L; Davidson, R C; Dorf, M; Gilson, E P; Kaganovich, I

    2009-09-24

    The Heavy Ion Fusion Science Virtual National Laboratory (a collaboration of LBNL, LLNL, and PPPL) is using intense ion beams to heat thin foils to the 'warm dense matter' regime at {approx}< 1 eV, and is developing capabilities for studying target physics relevant to ion-driven inertial fusion energy. The need for rapid target heating led to the development of plasma-neutralized pulse compression, with current amplification factors exceeding 50 now routine on the Neutralized Drift Compression Experiment (NDCX). Construction of an improved platform, NDCX-II, has begun at LBNL with planned completion in 2012. Using refurbished induction cells from the Advanced Test Accelerator at LLNL, NDCX-II will compress a {approx}500 ns pulse of Li{sup +} ions to {approx} 1 ns while accelerating it to 3-4 MeV over {approx} 15 m. Strong space charge forces are incorporated into the machine design at a fundamental level. We are using analysis, an interactive 1D PIC code (ASP) with optimizing capabilities and centroid tracking, and multi-dimensional Warpcode PIC simulations, to develop the NDCX-II accelerator. This paper describes the computational models employed, and the resulting physics design for the accelerator.

  5. Energy and Water Development Appropriation Bill, 1985. Report submitted by the Committee on Appropriations U. S. Senate, to the Ninety-Eighth Congress, Second Session, June 5, 1984

    SciTech Connect

    Not Available

    1984-01-01

    The Committee report on H.R. 5653 includes suggested amendments and information on the recommended changes in energy and water development appropriations for fiscal year 1985. Title I of the bill supplies funds for civilian projects of the Army Corps of Engineers; Title II, for reclamation projects of the Department of the Interior; Title III, for DOE defense, research, regulatory, geothermal, nuclear waste, power marketing, and uranium supply and enrichment activities; and Title IV, for independent agencies, including the Appalachian Regional Commission, Nuclear Regulatory Commission, and the Tennessee Valley Authority. The committee's recommendation of nearly $15.4 billion is $99.6 million below the budget estimates. The report covers information gathered during 17 hearing sessions, and represents a unanimous recommmendation by the committee.

  6. Interactive Session: U.S. & Developing Countries. A 2-Way Street. Report of an Interactive Session held at the National Conference of Librarians and International Development (3rd, Corvallis, Oregon, April 28-30, 1991).

    ERIC Educational Resources Information Center

    1991

    This working outline provides a detailed plan and background information for conference participants, who were assigned to assist the government and an institution in one of four developing countries in planning for the establishment and/or strengthening of a system's information capabilities over a 10-year period. These projects were: (1) the…

  7. Analysis of requirements for accelerating the development of geothermal energy resources in California

    NASA Technical Reports Server (NTRS)

    Fredrickson, C. D.

    1978-01-01

    Various resource data are presented showing that geothermal energy has the potential of satisfying a singificant part of California's increasing energy needs. General factors slowing the development of geothermal energy in California are discussed and required actions to accelerate its progress are presented. Finally, scenarios for developing the most promising prospects in the state directed at timely on-line power are given. Specific actions required to realize each of these individual scenarios are identified.

  8. 1975 Revised Guide to the Rural Development Act of 1972. 93d Congress, 2d Session, January 1, 1975.

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. Senate Committee on Agriculture, Nutrition, and Forestry.

    Prepared to assist both the Congress and the public involved in Rural Development (RD), the 1975 Revised Guide to the Rural Development Act of 1972 provides definitive and implemental information. Part 1 deals with the Act itself, detailing its purpose, historical perspective, and major provisions. Divided into three areas of concern, Part 2 deals…

  9. Teachers' Support in Using Computers for Developing Students' Listening and Speaking Skills in Pre-Sessional English Courses

    ERIC Educational Resources Information Center

    Zou, Bin

    2013-01-01

    Many computer-assisted language learning (CALL) studies have found that teacher direction can help learners develop language skills at their own pace on computers. However, many teachers still do not know how to provide support for students to use computers to reinforce the development of their language skills. Hence, more examples of CALL…

  10. Recent developments in the application of electron accelerators for polymer processing

    NASA Astrophysics Data System (ADS)

    Chmielewski, A. G.; Al-Sheikhly, M.; Berejka, A. J.; Cleland, M. R.; Antoniak, M.

    2014-01-01

    There are now over 1700 high current, electron beam (EB) accelerators being used world-wide in industrial applications, most of which involve polymer processing. In contrast to the use of heat, which transfers only about 5-10% of input energy into energy useful for materials modification, radiation processing is very energy efficient, with 60% or more of the input energy to an accelerator being available for affecting materials. Historic markets, such as the crosslinking of wire and cable jacketing, of heat shrinkable tubings and films, of partial crosslinking of tire components and of low-energy EB to cure or dry inks and coatings remain strong. Accelerator manufacturers have made equipment more affordable by down-sizing units while maintaining high beam currents. Very powerful accelerators with 700 kW output have made X-ray conversion a practical alternative to the historic use of radioisotopes, mainly cobalt-60, for applications as medical device sterilization. New EB end-uses are emerging, such as the development of nano-composites and nano-gels and the use of EB processing to facilitate biofuel production. These present opportunities for future research and development.

  11. Progress In Plasma Accelerator Development for Dynamic Formation of Plasma Liners

    NASA Technical Reports Server (NTRS)

    Thio, Y. C. Francis; Eskridge, Richard; Martin, Adam; Smith, James; Lee, Michael; Cassibry, Jason T.; Griffin, Steven; Rodgers, Stephen L. (Technical Monitor)

    2002-01-01

    An experimental plasma accelerator for magnetic target fusion (MTF) applications under development at the NASA Marshall Space Flight Center is described. The accelerator is a coaxial pulsed plasma thruster (Figure 1). It has been tested experimentally and plasma jet velocities of approx.50 km/sec have been obtained. The plasma jet has been photographed with 10-ns exposure times to reveal a stable and repeatable plasma structure (Figure 2). Data for velocity profile information has been obtained using light pipes and magnetic probes embedded in the gun walls to record the plasma and current transit respectively at various barrel locations. Preliminary spatially resolved spectral data and magnetic field probe data are also presented. A high speed triggering system has been developed and tested as a means of reducing the gun "jitter". This jitter is being characterized and future work for second generation "ultra-low jitter" gun development is being identified.

  12. A Wind-Tunnel Investigation of the Development of Lift on Wings in Accelerated Longitudinal Motion

    NASA Technical Reports Server (NTRS)

    Turner, Thomas R.

    1960-01-01

    An investigation was made in the Langley 300 MPH 7- by 10-foot tunnel to determine the development of lift on a wing during a simulated constant-acceleration catapult take-off. The investigation included models of a two-dimensional wing, an unswept wing having an aspect ratio of 6, a 35 deg. swept wing having an aspect ratio of 3.05, and a 60 deg. delta wing having an aspect ratio of 2.31. All the wings investigated developed at least 90 percent of their steady-state lift in the first 7 chord lengths of travel. The development of lift was essentially independent of the acceleration when based on chord lengths traveled, and was in qualitative agreement with theory.

  13. Twin-Screw Extruder and Pellet Accelerator Integration Developments for ITER

    SciTech Connect

    Meitner, Steven J; Baylor, Larry R; Combs, Stephen Kirk; Fehling, Dan T; Foust, Charles R; McGill, James M; Rasmussen, David A; Maruyama, So

    2011-01-01

    The ITER pellet injection system consisting of a twinscrew frozen hydrogen isotope extruder, coupled to a combination solenoid actuated pellet cutter and pneumatic pellet accelerator, is under development at the Oak Ridge National Laboratory. A prototype extruder has been built to produce a continuous solid deuterium extrusion and will be integrated with a secondary section, where pellets are cut, chambered, and launched with a single-stage pneumatic accelerator into the plasma through a guide tube. This integrated pellet injection system is designed to provide 5 mm fueling pellets, injected at a rate up to 10 Hz, or 3 mm edge localized mode (ELM) triggering pellets, injected at higher rates up to 20 Hz. The pellet cutter, chamber mechanism, and the solenoid operated pneumatic valve for the accelerator are optimized to provide pellet velocities between 200-300 m/s to ensure high pellet survivability while traversing the inner wall fueling guide tubes, and outer wall ELMpacing guide tubes. This paper outlines the current twin-screwextruder design, pellet accelerator design, and the integrationrequired for both fueling and ELM pacing pellets.

  14. Surface Transportation Research and Development Act of 1997. House of Representatives, One Hundred Fifth Congress, Second Session

    SciTech Connect

    1998-12-31

    Mr. Sensenbrenner, from the Committee on Science, submitted this report together with additional views. The Committee on Science, to whom was referred the bill (H.R. 860) to authorize appropriations to the Department of Transportation for surface transportation research and development, and for other purposes, having considered the same, report favorably thereon with an amendment and recommend that the bill as amended do pass.

  15. Introduction to Session 1B

    NASA Astrophysics Data System (ADS)

    Sticklen, Mariam B.

    Topics presented in the "Plant Biotechnology and Genomics" session focused on technologies that highlight the important role of plant biotechnology and genomics in the development of future energy crops. Several excellent presentations demonstrated the latest advances in energy crop development through the use of plant cell wall regulation and by engineering new energy crops such as brown midrib sweet sorghum. Approaches included the control of cellulose production by increased expression of cellulase synthase genes and the selection of high-yield varieties of shrub willows. The potential of producing hydrolytic enzymes using transgenic plants as a cost-effective means for the large-scale production of these enzymes was also explored in the session, as was the role of posttranslational modifications on the activities of heterologous expressed cellulases in hosts such as Pichia pastoris.

  16. Accelerating Preschoolers' Early Literacy Development through Classroom-Based Teacher-Child Storybook Reading and Explicit Print Referencing

    ERIC Educational Resources Information Center

    Justice, Laura M.; Kaderavek, Joan N.; Fan, Xitao; Sofka, Amy; Hunt, Aileen

    2009-01-01

    Purpose: This study examined the impact of teacher use of a print referencing style during classroom-based storybook reading sessions conducted over an academic year. Impacts on preschoolers' early literacy development were examined, focusing specifically on the domain of print knowledge. Method: This randomized, controlled trial examined the…

  17. Priority research areas to accelerate the development of practical ultraconductive copper conductors

    SciTech Connect

    Lee, Dominic F.; Burwell, Malcolm; Stillman, H.

    2015-09-01

    This report documents the findings at an Ultraconductive Copper Strategy Meeting held on March 11, 2015 in Washington DC. The aim of this meeting was to bring together researchers of ultraconductive copper in the U.S. to identify and prioritize critical non-proprietary research activities that will enhance the understanding in the material and accelerate its development into practical conductors. Every effort has been made to ensure that the discussion and findings are accurately reported in this document.

  18. Development of an accelerated reliability test schedule for terrestrial solar cells

    NASA Technical Reports Server (NTRS)

    Lathrop, J. W.; Prince, J. L.

    1981-01-01

    An accelerated test schedule using a minimum amount of tests and a minimum number of cells has been developed on the basis of stress test results obtained from more than 1500 cells of seven different cell types. The proposed tests, which include bias-temperature, bias-temperature-humidity, power cycle, thermal cycle, and thermal shock tests, use as little as 10 and up to 25 cells, depending on the test type.

  19. Development of a photovoltaic module qualification test based on combined-environment accelerated stress data

    NASA Astrophysics Data System (ADS)

    Trenchard, S. E.; Royal, E.; Anderson, R. T.

    The U.S. Coast Guard has developed a qualification test to screen photovoltaic modules for utilization on marine aids to navigation. The test is based on a combined-environment of hot and cold saltwater immersion and air pressurization. The test has demonstrated a very high acceleration factor and excellent correlation of electrical failures with modules in a concurrent real-time marine exposure.

  20. Development of a photovoltaic module qualification test based on combined-environment accelerated stress data

    NASA Technical Reports Server (NTRS)

    Trenchard, S. E.; Royal, E.; Anderson, R. T.

    1982-01-01

    The U.S. Coast Guard has developed a qualification test to screen photovoltaic modules for utilization on marine aids to navigation. The test is based on a combined-environment of hot and cold saltwater immersion and air pressurization. The test has demonstrated a very high acceleration factor and excellent correlation of electrical failures with modules in a concurrent real-time marine exposure.

  1. Requirements and Development of an Acceleration Measurement System for International Space Station Microgravity Science Payloads

    NASA Technical Reports Server (NTRS)

    Sutliff, Thomas J.

    1997-01-01

    The International Space Station is being developed by NASA and international partners as a versatile user platform to allow long term on-orbit investigations of a variety of scientific and technology arenas. In particular, scientific studies are planned within a research class known as microgravity science in areas such as biotechnology, combustion, fluid physics, and materials sciences. An acceleration measurement system is in development to aid such research conducted in the on-orbit conditions of apparent weightlessness. This system provides a general purpose acceleration measurement capability in support of these payloads and investigators. Such capability allows for systematic study of scientific phenomena by obtaining information regarding the local accelerations present during experiment operations. Preparations for implementing this flight measurement system involves two distinct stages: requirements development prior to initiating the design activity, and the design activity itself. This paper defines the requirements definition approach taken, provides an overview of the results of the requirements phase, and outlines the initial design considerations being addressed for this measurement system. Some preliminary engineering approaches are also described.

  2. The trade-off between maturation and growth during accelerated development in frogs.

    PubMed

    Mueller, Casey A; Augustine, Starrlight; Kooijman, Sebastiaan A L M; Kearney, Michael R; Seymour, Roger S

    2012-09-01

    Developmental energetics are crucial to a species' life history and ecology but are poorly understood from a mechanistic perspective. Traditional energy and mass budgeting does not distinguish between costs of growth and maturation, making it difficult to account for accelerated development. We apply a metabolic theory that uniquely considers maturation costs (Dynamic Energy Budget theory, DEB) to interpret empirical data on the energetics of accelerated development in amphibians. We measured energy use until metamorphosis in two related frogs, Crinia georgiana and Pseudophryne bibronii. Mass and energy content of fresh ova were comparable between the species. However, development to metamorphosis was 1.7 times faster in C. georgiana while P. bibronii produced nine times the dry biomass at metamorphosis and had lower mass-specific oxygen requirements. DEB theory explained these patterns through differences in ontogenetic energy allocation to maturation. P. bibronii partitioned energy in the same (constant) way throughout development whereas C. georgiana increased the fraction of energy allocated to maturation over growth between hatching and the onset of feeding. DEB parameter estimation for additional, direct-developing taxa suggests that a change in energy allocation during development may result from a selective pressure to increase development rate, and not as a result of development mode. PMID:22613786

  3. Development of a Dielectric-Loaded Accelerator Test Facility Based on an X-Band Magnicon Amplifier

    SciTech Connect

    Gold, S. H.; Fliflet, A. W.; Kinkead, A. K.; Gai, W.; Power, J. G.; Konecny, R.; Jing, C.; Tantawi, S. G.; Nantista, C. D.; Hu, Y.; Du, X.; Tang, C.; Lin, Y.; Bruce, R. W.; Bruce, R. L.; Lewis, D. III

    2006-01-03

    The Naval Research Laboratory (NRL) and Argonne National Laboratory (ANL), in collaboration with the Stanford Linear Accelerator Center (SLAC), are developing a dielectric-loaded accelerator (DLA) test facility powered by the 11.424-GHz magnicon amplifier that was developed jointly by NRL and Omega-P, Inc. Thus far, DLA structures developed by ANL have been tested at the NRL Magnicon Facility without injected electrons, including tests of alumina and magnesium calcium titanate structures at gradients up to {approx}8 MV/m. The next step is to inject electrons in order to build a compact DLA test accelerator. The Accelerator Laboratory of Tsinghua University in Beijing, China has developed a 5-MeV electron injector for the accelerator, and SLAC is developing a means to combine the two magnicon output arms, and to drive the injector and an accelerator section with separate control of the power ratio and relative phase. Also, RWBruce Associates, working with NRL, is developing a means to join ceramic tubes to produce long accelerating sections using a microwave brazing process. The installation and commissioning of the first dielectric-loaded test accelerator, including injector, DLA structure, and spectrometer, should take place within the next year.

  4. Can Accelerators Accelerate Learning?

    NASA Astrophysics Data System (ADS)

    Santos, A. C. F.; Fonseca, P.; Coelho, L. F. S.

    2009-03-01

    The 'Young Talented' education program developed by the Brazilian State Funding Agency (FAPERJ) [1] makes it possible for high-schools students from public high schools to perform activities in scientific laboratories. In the Atomic and Molecular Physics Laboratory at Federal University of Rio de Janeiro (UFRJ), the students are confronted with modern research tools like the 1.7 MV ion accelerator. Being a user-friendly machine, the accelerator is easily manageable by the students, who can perform simple hands-on activities, stimulating interest in physics, and getting the students close to modern laboratory techniques.

  5. Development of an ion beam analyzing system for the KBSI heavy-ion accelerator.

    PubMed

    Bahng, Jungbae; Hong, Jonggi; Park, Jin Yong; Kim, Seong Jun; Ok, Jung-Woo; Choi, Seyong; Shin, Chang Seouk; Yoon, Jang-Hee; Won, Mi-Sook; Lee, Byoung-Seob; Kim, Eun-San

    2016-02-01

    The Korea Basic Science Institute (KBSI) has been developing a heavy ion accelerator system to accelerate high current, multi-charge state ions produced by a 28 GHz superconducting electron cyclotron ion source. A beam analyzing system as a part of the low energy beam transport apparatus was developed to select charged particles with desirable charge states from the ion beams. The desired species of ion, which is generated and extracted from the ECR ion source including various ion particles, can be selected by 90° dipole electromagnet. Due to the non-symmetrical structure in the coil as well as the non-linear permeability of the yoke material coil, a three dimensional analysis was carried out to confirm the design parameters. In this paper, we present the experimental results obtained as result of an analysis of KBSI accelerator. The effectiveness of beam selection was confirmed during the test of the analyzing system by injecting an ion beam from an ECR ion source. PMID:26932105

  6. Development of an ion beam analyzing system for the KBSI heavy-ion accelerator

    NASA Astrophysics Data System (ADS)

    Bahng, Jungbae; Hong, Jonggi; Park, Jin Yong; Kim, Seong Jun; Ok, Jung-Woo; Choi, Seyong; Shin, Chang Seouk; Yoon, Jang-Hee; Won, Mi-Sook; Lee, Byoung-Seob; Kim, Eun-San

    2016-02-01

    The Korea Basic Science Institute (KBSI) has been developing a heavy ion accelerator system to accelerate high current, multi-charge state ions produced by a 28 GHz superconducting electron cyclotron ion source. A beam analyzing system as a part of the low energy beam transport apparatus was developed to select charged particles with desirable charge states from the ion beams. The desired species of ion, which is generated and extracted from the ECR ion source including various ion particles, can be selected by 90° dipole electromagnet. Due to the non-symmetrical structure in the coil as well as the non-linear permeability of the yoke material coil, a three dimensional analysis was carried out to confirm the design parameters. In this paper, we present the experimental results obtained as result of an analysis of KBSI accelerator. The effectiveness of beam selection was confirmed during the test of the analyzing system by injecting an ion beam from an ECR ion source.

  7. Update on the development of externally powered dielectric-loaded accelerating structures.

    SciTech Connect

    Jing, C.; Gai, W.; Konecny, R.; Power, J. G.; Liu, W.; Kanareykin, A.; Gold, S.; Kinkead, A. K.; High Energy Physics; EuclidTechlabs,; Naval Research Lab.; Icarus Research

    2009-01-01

    We report on recent progress in a program to develop an RF-driven Dielectric-Loaded Accelerating (DLA) structure, capable of supporting high gradient acceleration. Previous high power tests revealed that the earlier DLA structures suffered from multipactor and arcing at the dielectric joint. A few new DLA structures have been designed to alleviate this limitation including the coaxial coupler based DLA structure and the clamped DLA structure. These structures were recently fabricated and high power tested at the NRL X-band Magnicon facility. Results show the multipactor can be reduced by the TiN coating on the dielectric surface. Gradient of 15 MV/m has also been tested without dielectric breakdown in the test of the clamped DLA structure. Detailed results are reported, and future plans discussed.

  8. Testing Done for Lorentz Force Accelerators and Electrodeless Propulsion Technology Development

    NASA Technical Reports Server (NTRS)

    Pencil, Eric J.; Gilland, James H.; Arrington, Lynn A.; Kamhawi, Hani

    2004-01-01

    The NASA Glenn Research Center is developing Lorentz force accelerators and electrodeless plasma propulsion for a wide variety of space applications. These applications range from precision control of formation-flying spacecraft to primary propulsion for very high power interplanetary spacecraft. The specific thruster technologies being addressed are pulsed plasma thrusters, magnetoplasmadynamic thrusters, and helicon-electron cyclotron resonance acceleration thrusters. The pulsed plasma thruster mounted on the Earth Observing-1 spacecraft was operated successfully in orbit in 2002. The two-axis thruster system is fully incorporated in the attitude determination and control system and is being used to automatically counteract disturbances in the pitch axis of the spacecraft. Recent on-orbit operations have focused on extended operations to add flight operation time to the total accumulated thruster life. The results of the experiments pave the way for electric propulsion applications on future Earth-imaging satellites.

  9. Update on the Development of Externally Powered Dielectric-Loaded Accelerating Structures

    SciTech Connect

    Jing, C.; Kanareykin, A.; Gai, W.; Konecny, R.; Power, J. G.; Liu, W.; Gold, S. H.; Kinkead, A. K.

    2009-01-22

    We report on recent progress in a program to develop an RF-driven Dielectric-Loaded Accelerating (DLA) structure, capable of supporting high gradient acceleration. Previous high power tests revealed that the earlier DLA structures suffered from multipactor and arcing at the dielectric joint. A few new DLA structures have been designed to alleviate this limitation including the coaxial coupler based DLA structure and the clamped DLA structure. These structures were recently fabricated and high power tested at the NRL X-band Magnicon facility. Results show the multipactor can be reduced by the TiN coating on the dielectric surface. Gradient of 15 MV/m has also been tested without dielectric breakdown in the test of the clamped DLA structure. Detailed results are reported, and future plans discussed.

  10. Development of Wind-and-React Bi-2212 Accelerator Magnet Technology

    SciTech Connect

    Godeke, A.; Cheng, D.; Dietderich, D. R.; English, C. D.; Felice, H.; Hannaford, C. R.; Prestemon, S. O.; Sabbi, G.; Scanlan, R. M.; Hikichi, Y.; Nishioka, J.; Hasegawa, T.

    2007-08-28

    We report on the progress in our R&D program, targeted to develop the technology for the application of Bi2Sr2CaCu2Ox (Bi-2212) in accelerator magnets. The program uses subscale coils, wound from insulated cables, to study suitable materials, heat treatment homogeneity, stability, and effects of magnetic field and thermal and electro-magnetic loads. We have addressed material and reaction related issues and report on the fabrication, heat treatment, and analysis of subscale Bi-2212 coils. Such coils can carry a current on the order of 5000 A and generate, in various support structures, magnetic fields from 2.6 to 9.9 T. Successful coils are therefore targeted towards a hybrid Nb3Sn-HTS magnet which will demonstrate the feasibility of Bi-2212 for accelerator magnets, and open a new magnetic field realm, beyond what is achievable with Nb3Sn.

  11. Recent Progress in the Development of a Circular Ion Induction Accelerator for Space Charge Dominated Beams

    NASA Astrophysics Data System (ADS)

    Ahle, L.; Sangster, T. C.; Autrey, D.; Barnard, J.; Craig, G.; Friedman, A.; Grote, D. P.; Halaxa, E.; Hanks, R. L.; Hernandez, M.; Kirbie, H. C.; Logan, B. G.; Lund, S. M.; Mant, G.; Molvik, A.; Sharp, W.; Berners, D.; Eylon, S.; Judd, D. L.; Reginato, L.; Debeling, A.; Fritz, W.

    1998-11-01

    The Heavy Ion Fusion Group at Lawrence Livermore National Laboratory has been developing the world's first ion induction accelerator. This machine has recently been extended to 90 degress, or 10 half-lattice periods(HLP) with full beam transport. As part of this extension, two new diagnostic systems have been fully enabled, the Capacitive Beam Probes(C-probes) and the Gated Beam Imager(GBI). The C-probes measure the charge centroid of the beam in each HLP and the GBI measures emittance in both transverse planes. Output from both diagnostics will be presented. In addition, induction cores have been installed on five of the HLP's, in anticipation of the first attempts at acceleration. The status of these attempts will also be discussed.

  12. Development of an S-band accelerating structure with quasi-symmetric single-feed racetrack couplers

    NASA Astrophysics Data System (ADS)

    Heo, Hoon; Joo, Young-Do; Park, Yong-Jung; Kang, Heung-Sik; Lee, Heung-Soo; Oh, Kyoung-Min; Seo, Hyung-Seok; Noh, Sung-Ju

    2015-03-01

    We developed an S-band traveling-wave accelerating structure for the Pohang Accelerator Laboratory's X-ray free-electron laser (PAL-XFEL), and we fabricated and tested a full-scale prototype. In order to reduce the field asymmetry inside the coupler cavity, we used the SUPERFISH code and the CST MWS electromagnetic field solvers to design the constant-gradient traveling-wave accelerator to use quasi-symmetric single-feed racetrack couplers. The RF measurement results indicate that the accelerating gradient of the prototype structure is as high as 27 MV/m for an input RF power of 65 MW.

  13. Physician's Breakout Session

    NASA Technical Reports Server (NTRS)

    Barry, William

    2001-01-01

    Dr. William Barry, Manager, NASA Occupational Health Program, moderated this session. As in one of the opening sessions, he re-iterated that the overall theme for the next year will be facilitating and implementing NIAT-1 (NASA Integrated Action Team - Action 1). He presented a candidate list of topics for consideration and discussion: (1) NIAT-1; (2) Skin cancer detection and the NASA Solar Safe Program; (3) Weapons of mass destruction; (4) Quality assurance; (5) Audits; (6) Environment of care; (7) Infection control; (8) Medication management; and (9) Confidentiality of medical records.

  14. Increasing Spontaneous Retinal Activity before Eye Opening Accelerates the Development of Geniculate Receptive Fields

    PubMed Central

    Davis, Zachary W.; Chapman, Barbara

    2015-01-01

    Visually evoked activity is necessary for the normal development of the visual system. However, little is known about the capacity for patterned spontaneous activity to drive the maturation of receptive fields before visual experience. Retinal waves provide instructive retinotopic information for the anatomical organization of the visual thalamus. To determine whether retinal waves also drive the maturation of functional responses, we increased the frequency of retinal waves pharmacologically in the ferret (Mustela putorius furo) during a period of retinogeniculate development before eye opening. The development of geniculate receptive fields after receiving these increased neural activities was measured using single-unit electrophysiology. We found that increased retinal waves accelerate the developmental reduction of geniculate receptive field sizes. This reduction is due to a decrease in receptive field center size rather than an increase in inhibitory surround strength. This work reveals an instructive role for patterned spontaneous activity in guiding the functional development of neural circuits. SIGNIFICANCE STATEMENT Patterned spontaneous neural activity that occurs during development is known to be necessary for the proper formation of neural circuits. However, it is unknown whether the spontaneous activity alone is sufficient to drive the maturation of the functional properties of neurons. Our work demonstrates for the first time an acceleration in the maturation of neural function as a consequence of driving patterned spontaneous activity during development. This work has implications for our understanding of how neural circuits can be modified actively to improve function prematurely or to recover from injury with guided interventions of patterned neural activity. PMID:26511250

  15. Recent developments in rf superconductivity for high-brightness and high-gradient ion beam accelerators

    SciTech Connect

    Delayen, J.R.; Bohn, C.L.; Kennedy, W.L.; Nichols, G.L.; Roche, C.T.; Sagalovsky, L.

    1992-01-01

    Recent progress in on-going development program leading to the design of superconducting continuous-wave (cw) linear accelerators for high-brightness ion beams is reviewed. A new spoke-resonator geometry incorporating a half-wavelength resonant line was fabricated and tested. This geometry serves as the basis for the constituent cavities of a superconducting section being designed for high-current testing with a deuterium beam. Considerable progress has been made in the design of this section. A multi-phased program leading to the development of a superconducting radio-frequency quadrupole (SCRFQ) has been initiated. Design considerations and test results from the various activities are presented.

  16. Recent developments in rf superconductivity for high-brightness and high-gradient ion beam accelerators

    SciTech Connect

    Delayen, J.R.; Bohn, C.L.; Kennedy, W.L.; Nichols, G.L.; Roche, C.T.; Sagalovsky, L.

    1992-02-01

    Recent progress in on-going development program leading to the design of superconducting continuous-wave (cw) linear accelerators for high-brightness ion beams is reviewed. A new spoke-resonator geometry incorporating a half-wavelength resonant line was fabricated and tested. This geometry serves as the basis for the constituent cavities of a superconducting section being designed for high-current testing with a deuterium beam. Considerable progress has been made in the design of this section. A multi-phased program leading to the development of a superconducting radio-frequency quadrupole (SCRFQ) has been initiated. Design considerations and test results from the various activities are presented.

  17. Education and Skills for Development in South Africa: Reflections on the Accelerated and Shared Growth Initiative for South Africa

    ERIC Educational Resources Information Center

    McGrath, S.; Akoojee, Salim

    2007-01-01

    In July 2005, President Mbeki announced the launch of the Accelerated and Shared Growth Initiative for South Africa (AsgiSA), a new development strategy designed to help the South African state meet the ANC's 2004 election pledges, namely: (1) halve unemployment; (2) halve poverty; (3) accelerate employment equity; and (4) improve broad-based…

  18. Accelerating vaccine development and deployment: report of a Royal Society satellite meeting

    PubMed Central

    Bregu, Migena; Draper, Simon J.; Hill, Adrian V. S.; Greenwood, Brian M.

    2011-01-01

    The Royal Society convened a meeting on the 17th and 18th November 2010 to review the current ways in which vaccines are developed and deployed, and to make recommendations as to how each of these processes might be accelerated. The meeting brought together academics, industry representatives, research sponsors, regulators, government advisors and representatives of international public health agencies from a broad geographical background. Discussions were held under Chatham House rules. High-throughput screening of new vaccine antigens and candidates was seen as a driving force for vaccine discovery. Multi-stakeholder, small-scale manufacturing facilities capable of rapid production of clinical grade vaccines are currently too few and need to be expanded. In both the human and veterinary areas, there is a need for tiered regulatory standards, differentially tailored for experimental and commercial vaccines, to allow accelerated vaccine efficacy testing. Improved cross-fertilization of knowledge between industry and academia, and between human and veterinary vaccine developers, could lead to more rapid application of promising approaches and technologies to new product development. Identification of best-practices and development of checklists for product development plans and implementation programmes were seen as low-cost opportunities to shorten the timeline for vaccine progression from the laboratory bench to the people who need it. PMID:21893549

  19. Accelerating vaccine development and deployment: report of a Royal Society satellite meeting.

    PubMed

    Bregu, Migena; Draper, Simon J; Hill, Adrian V S; Greenwood, Brian M

    2011-10-12

    The Royal Society convened a meeting on the 17th and 18th November 2010 to review the current ways in which vaccines are developed and deployed, and to make recommendations as to how each of these processes might be accelerated. The meeting brought together academics, industry representatives, research sponsors, regulators, government advisors and representatives of international public health agencies from a broad geographical background. Discussions were held under Chatham House rules. High-throughput screening of new vaccine antigens and candidates was seen as a driving force for vaccine discovery. Multi-stakeholder, small-scale manufacturing facilities capable of rapid production of clinical grade vaccines are currently too few and need to be expanded. In both the human and veterinary areas, there is a need for tiered regulatory standards, differentially tailored for experimental and commercial vaccines, to allow accelerated vaccine efficacy testing. Improved cross-fertilization of knowledge between industry and academia, and between human and veterinary vaccine developers, could lead to more rapid application of promising approaches and technologies to new product development. Identification of best-practices and development of checklists for product development plans and implementation programmes were seen as low-cost opportunities to shorten the timeline for vaccine progression from the laboratory bench to the people who need it. PMID:21893549

  20. Performance and Environmental Test Results of the High Voltage Hall Accelerator Engineering Development Unit

    NASA Technical Reports Server (NTRS)

    Kamhawi, Hani; Haag, Thomas; Huang, Wensheng; Shastry, Rohit; Pinero, Luis; Peterson, Todd; Mathers, Alex

    2012-01-01

    NASA Science Mission Directorate's In-Space Propulsion Technology Program is sponsoring the development of a 3.5 kW-class engineering development unit Hall thruster for implementation in NASA science and exploration missions. NASA Glenn and Aerojet are developing a high fidelity high voltage Hall accelerator that can achieve specific impulse magnitudes greater than 2,700 seconds and xenon throughput capability in excess of 300 kilograms. Performance, plume mappings, thermal characterization, and vibration tests of the high voltage Hall accelerator engineering development unit have been performed. Performance test results indicated that at 3.9 kW the thruster achieved a total thrust efficiency and specific impulse of 58%, and 2,700 sec, respectively. Thermal characterization tests indicated that the thruster component temperatures were within the prescribed material maximum operating temperature limits during full power thruster operation. Finally, thruster vibration tests indicated that the thruster survived the 3-axes qualification full-level random vibration test series. Pre and post-vibration test performance mappings indicated almost identical thruster performance. Finally, an update on the development progress of a power processing unit and a xenon feed system is provided.

  1. WInd-and-react Bi-2212 coil development for accelerator magnets

    SciTech Connect

    Godeke, A.; Acosta, P.; Cheng, D.; Dietderich, D. R.; Mentink, M. G. T.; Prestemon, S. O.; Meinesz, M.; Hong, S.; Huang, Y.; Miao, H.; Parrell, J.; Sabbi, G.L.

    2009-10-13

    Sub-scale coils are being manufactured and tested at Lawrence Berkeley National Laboratory in order to develop wind-and-react Bi{sub 2}Sr{sub 2}CaCu{sub 2}O{sub x} (Bi-2212) magnet technology for future graded accelerator magnet use. Previous Bi-2212 coils showed significant leakage of the conductors core constituents to the environment, which can occur during the partial melt reaction around 890 C in pure oxygen. The main origin of the observed leakage is intrinsic leakage of the wires, and the issue is therefore being addressed at the wire manufacturing level. We report on further compatibility studies, and the performance of new sub-scale coils that were manufactured using improved conductors. These coils exhibit significantly reduced leakage, and carry currents that are about 70% of the witness wire critical current (I{sub c}). The coils demonstrate, for the first time, the feasibility of round wire Bi-2212 conductors for accelerator magnet technology use. Successful high temperature superconductor coil technology will enable the manufacture of graded accelerator magnets that can surpass the, already closely approached, intrinsic magnetic field limitations of Nb-based superconducting magnets.

  2. Accelerator production of tritium plant design and supporting engineering development and demonstration work

    SciTech Connect

    Lisowski, P.W.

    1997-11-01

    Tritium is an isotope of hydrogen with a half life of 12.3 years. Because it is essential for US thermonuclear weapons to function, tritium must be periodically replenished. Since K reactor at Savannah River Site stopped operating in 1988, tritium has been recycled from dismantled nuclear weapons. This process is possible only as long as many weapons are being retired. Maintaining the stockpile at the level called for in the present Strategic Arms Reduction Treaty (START-I) will require the Department of Energy to have an operational tritium production capability in the 2005--2007 time frame. To make the required amount of tritium using an accelerator based system (APT), neutrons will be produced through high energy proton reactions with tungsten and lead. Those neutrons will be moderated and captured in {sup 3}He to make tritium. The APT plant design will use a 1,700 MeV linear accelerator operated at 100 mA. In preparation for engineering design, starting in October 1997 and subsequent construction, a program of engineering development and demonstration is underway. That work includes assembly and testing of the first 20 MeV of the low energy plant linac at 100 mA, high-energy linac accelerating structure prototyping, radiofrequency power system improvements, neutronic efficiency measurements, and materials qualifications.

  3. Vibration-Based Method Developed to Detect Cracks in Rotors During Acceleration Through Resonance

    NASA Technical Reports Server (NTRS)

    Sawicki, Jerzy T.; Baaklini, George Y.; Gyekenyesi, Andrew L.

    2004-01-01

    In recent years, there has been an increasing interest in developing rotating machinery shaft crack-detection methodologies and online techniques. Shaft crack problems present a significant safety and loss hazard in nearly every application of modern turbomachinery. In many cases, the rotors of modern machines are rapidly accelerated from rest to operating speed, to reduce the excessive vibrations at the critical speeds. The vibration monitoring during startup or shutdown has been receiving growing attention (ref. 1), especially for machines such as aircraft engines, which are subjected to frequent starts and stops, as well as high speeds and acceleration rates. It has been recognized that the presence of angular acceleration strongly affects the rotor's maximum response to unbalance and the speed at which it occurs. Unfortunately, conventional nondestructive evaluation (NDE) methods have unacceptable limits in terms of their application for online crack detection. Some of these techniques are time consuming and inconvenient for turbomachinery service testing. Almost all of these techniques require that the vicinity of the damage be known in advance, and they can provide only local information, with no indication of the structural strength at a component or system level. In addition, the effectiveness of these experimental techniques is affected by the high measurement noise levels existing in complex turbomachine structures. Therefore, the use of vibration monitoring along with vibration analysis has been receiving increasing attention.

  4. Advanced laser particle accelerator development at LANL: from fast ignition to radiation oncology

    SciTech Connect

    Flippo, Kirk A; Gaillard, Sandrine A; Offermann, D T; Cobble, J A; Schmitt, M J; Gautier, D C; Kwan, T J T; Montgomery, D S; Kluge, Thomas; Bussmann, Micheal; Bartal, T; Beg, F N; Gall, B; Geissel, M; Korgan, G; Kovaleski, S; Lockard, T; Malekos, S; Schollmeier, M; Sentoku, Y; Cowan, T E

    2010-01-01

    Laser-plasma accelerated ion and electron beam sources are an emerging field with vast prospects, and promise many superior applications in a variety of fields such as hadron cancer therapy, compact radioisotope generation, table-top nuclear physics, laboratory astrophysics, nuclear forensics, waste transmutation, SN M detection, and inertial fusion energy. LANL is engaged in several projects seeking to develop compact high current and high energy ion and electron sources. We are especially interested in two specific applications: ion fast ignition/capsule perturbation and radiation oncology in conjunction with our partners at the ForschungsZentrum Dresden-Rossendorf (FZD). Laser-to-beam conversion efficiencies of over 10% are needed for practical applications, and we have already shown inherent etliciencies of >5% from flat foils, on Trident using only a 5th of the intensity and energy of the Nova Petawatt. With clever target designs, like structured curved cone targets, we have also been able to achieve major ion energy gains, leading to the highest energy laser-accelerated proton beams in the world. These new target designs promise to help usher in the next generation of particle sources realizing the potential of laser-accelerated beams.

  5. Development of High Gradient Laser Wakefield Accelerators Towards Nuclear Detection Applications at LBNL

    SciTech Connect

    Geddes, Cameron G. R.; Gonsalves, Anthony J.; Lin Chen; Cormier-Michel, Estelle; Matlis, Nicholas H.; Panasenko, Dmitriy; Plateau, Guillaume R.; Schroeder, Carl B.; Toth, Csaba; Bruhwiler, David L.; Cary, John R.; Esarey, Eric H.; Nakamura, Kei; Bakeman, Mike; Leemans, Wim P.

    2009-03-10

    Compact high-energy linacs are important to applications including monochromatic gamma sources for nuclear material security applications. Recent laser wakefield accelerator experiments at LBNL demonstrated narrow energy spread beams, now with energies of up to 1 GeV in 3 cm using a plasma channel at low density. This demonstrates the production of GeV beams from devices much smaller than conventional linacs, and confirms the anticipated scaling of laser driven accelerators to GeV energies. Stable performance at 0.5 GeV was demonstrated. Experiments and simulations are in progress to control injection of particles into the wake and hence to improve beam quality and stability. Using plasma density gradients to control injection, stable beams at 1 MeV over days of operation, and with an order of magnitude lower absolute momentum spread than previously observed, have been demonstrated. New experiments are post-accelerating the beams from controlled injection experiments to increase beam quality and stability. Thomson scattering from such beams is being developed to provide collimated multi-MeV monoenergetic gamma sources for security applications from compact devices. Such sources can reduce dose to target and increase accuracy for applications including photofission and nuclear resonance fluorescence.

  6. Development of high gradient laser wakefield accelerators towards nuclear detection applications at LBNL

    SciTech Connect

    Geddes, Cameron GR; Bruhwiler, David L.; Cary, John R.; Esarey, Eric H.; Gonsalves, Anthony J.; Lin, Chen; Cormier-Michel, Estelle; Matlis, Nicholas H.; Nakamura, Kei; Bakeman, Mike; Panasenko, Dmitriy; Plateau, Guillaume R.; Schroeder, Carl B.; Toth, Csaba; Leemans, Wim P.

    2008-09-08

    Compact high-energy linacs are important to applications including monochromatic gamma sources for nuclear material security applications. Recent laser wakefield accelerator experiments at LBNL demonstrated narrow energy spread beams, now with energies of up to 1 GeV in 3 cm using a plasma channel at low density. This demonstrates the production of GeV beams from devices much smaller than conventional linacs, and confirms the anticipated scaling of laser driven accelerators to GeV energies. Stable performance at 0.5 GeV was demonstrated. Experiments and simulations are in progress to control injection of particles into the wake and hence to improve beam quality and stability. Using plasma density gradients to control injection, stable beams at 1 MeV over days of operation, and with an order of magnitude lower absolute momentum spread than previously observed, have been demonstrated. New experiments are post-accelerating the beams from controlled injection experiments to increase beam quality and stability. Thomson scattering from such beams is being developed to provide collimated multi-MeV monoenergetic gamma sources for security applications from compact devices. Such sources can reduce dose to target and increase accuracy for applications including photofission and nuclear resonance fluorescence.

  7. Development of backsheet tests and measurements to improve correlation of accelerated exposures to fielded modules

    NASA Astrophysics Data System (ADS)

    Felder, Thomas C.; Gambogi, William J.; Kopchick, James G.; Amspacher, Lucas; Peacock, R. Scott; Foltz, Benjamin; Stika, Katherine M.; Bradley, Alexander Z.; Hamzavy, Babak; Yu, Bao-Ling; Garreau-iles, Lucie; Fu, Oakland; Hu, Hongjie; Trout, T. John

    2015-09-01

    Matching accelerated test results to field observations is an important objective in the photovoltaic industry. We continue to develop test methods to strengthen correlations. We have previously reported good correlation of FTIR spectra between accelerated tests and field measurements. The availability of portable FTIR spectrometers has made measurement in the field convenient and reliable. Recently, nano-indentation has shown promise to correlate changes in backsheet mechanical properties. A precisely shaped stylus is pressed into a sample, load vs displacement recorded and mechanical properties of interest calculated in a nondestructive test. This test can be done on full size modules, allowing area variations in mechanical properties to be recorded. Finally, we will discuss optical profilometry. In this technique a white light interferogram of a surface is Fourier transformed to produce a three-dimensional image. Height differences from 1 nm to 5 mm can be detected over an area of a few cm. This technique can be used on minimodules, and is useful to determine crack and defect dimensions. Results will be presented correlating accelerated tests with fielded modules covering spectroscopic, mechanical, and morphological changes.

  8. Development of a multiplexed electrospray micro-thruster with post-acceleration and beam containment

    NASA Astrophysics Data System (ADS)

    Lenguito, G.; Gomez, A.

    2013-10-01

    We report the development of a compact thruster based on Multiplexed ElectroSprays (MES). It relied on a microfabricated Si array of emitters coupled with an extractor electrode and an accelerator electrode. The accelerator stage was introduced for two purposes: containing beam opening and avoiding electrode erosion due to droplet impingement, as well as boosting specific impulse and thrust. Multiplexing is generally necessary as a thrust multiplier to reach eventually the level required (O(102) μN) by small satellites. To facilitate system optimization and debugging, we focused on a 7-nozzle MES device and compared its performance to that of a single emitter. To ensure uniformity of operation of all nozzles their hydraulic impedance was augmented by packing them with micrometer-size beads. Two propellants were tested: a solution of 21.5% methyl ammonium formate in formamide and the better performing pure ionic liquid ethyl ammonium nitrate (EAN). The 7-MES device spraying EAN at ΔV = 5.93 kV covered a specific impulse range from 620 s to 1900 s and a thrust range from 0.6 μN to 5.4 μN, at 62% efficiency. Remarkably, less than 1% of the beam was demonstrated to impact on the accelerator electrode, which bodes well for long-term applications in space.

  9. Using Uncertainty Analysis to Guide the Development of Accelerated Stress Tests (Presentation)

    SciTech Connect

    Kempe, M.

    2014-03-01

    Extrapolation of accelerated testing to the long-term results expected in the field has uncertainty associated with the acceleration factors and the range of possible stresses in the field. When multiple stresses (such as temperature and humidity) can be used to increase the acceleration, the uncertainty may be reduced according to which stress factors are used to accelerate the degradation.

  10. Teacher Attitudes toward Subject-Specific Acceleration: Instrument Development and Validation

    ERIC Educational Resources Information Center

    Rambo, Karen E.; McCoach, D. Betsy

    2012-01-01

    Despite the research supporting acceleration, some teachers are still hesitant to recommend acceleration for advanced students. The Teacher Attitudes Toward Subject-Specific Acceleration (TATSSA) instrument was designed to uncover the factors that influence teacher decisions to recommend students for subject-specific acceleration. First, we…

  11. An Observing Session

    NASA Astrophysics Data System (ADS)

    Argyle, Bob; Argyle, R. W.

    In this chapter I describe a typical observing session with the 8-in. (20-cm) Thorrowgood refractor at the Institute of Astronomy in Cambridge. The telescope belongs to the Royal Astronomical Society but is on permanent loan to the Cambridge University Astronomical Society and has been on its present site since 1930 (Fig. 24.1).

  12. Student Poster Sessions

    ERIC Educational Resources Information Center

    Baumgartner, Erin

    2004-01-01

    Poster presentations are one way scientists present their latest research findings at professional meetings. This format also works well in the classroom and gives students the opportunity to communicate the results of their experiments (perhaps the most critical portion of their studies). In a performance-based task such as a poster session,…

  13. Summary of Session III

    SciTech Connect

    Furman, M.A.

    2002-06-19

    This is a summary of the talks presented in Session III ''Simulations of Electron-Cloud Build Up'' of the Mini-Workshop on Electron-Cloud Simulations for Proton and Positron Beams ECLOUD-02, held at CERN, 15-18 April 2002.

  14. Abstracts of SIG Sessions.

    ERIC Educational Resources Information Center

    Proceedings of the ASIS Annual Meeting, 1995

    1995-01-01

    Presents abstracts of 15 special interest group (SIG) sessions. Topics include navigation and information utilization in the Internet, natural language processing, automatic indexing, image indexing, classification, users' models of database searching, online public access catalogs, education for information professions, information services,…

  15. The outreach sessions

    SciTech Connect

    Trache, Livius

    2015-02-24

    These are moderator’s remarks about the outreach day in the middle of the CSSP14, and in particular about the afternoon outreach session in round table format with the announced theme: “CERN at 60 and the internationalization of science”.

  16. Neurovestibular Session Summary

    NASA Technical Reports Server (NTRS)

    Oman, Charles; Cohen, Malcolm

    1999-01-01

    Oman - The early mission operational problems caused by space motion sickness have been largely resolved in recent years. This has been achieved by appropriate timeline adjustments, voluntary head movement restriction, and judicious use of promethazine. Crew members now simply accept that some symptoms "come with the job," and usually last only a few days. But as more people have flown longer flights, we've seen cases of space sickness and inversion illusion that take several weeks to resolve. Visual reorientation illusions continue throughout long flights, and occasionally cause difficulties. EVA astronauts sometimes suddenly fear they will fall out of the payload bay or off of the RMS or Strella arms. Orientation and navigation in three dimensions in the MIR station reportedly does not come naturally, because modules have different visual verticals. It is clear that the neurovestibular problems of spaceflight have not disappeared. After return to Earth, many crew members are disoriented and ataxic in the first hour after return, and require assistance leaving the vehicle, Flight surgeons say that the longer the mission, the stronger the aftereffects, certain of which last for weeks. We do not yet know how to predict who will be afflicted. Looking ahead to 3-4 month long voyages to Mars, it seems obvious that if cruise is in O-G, the crew may encounter neurovestibular problems on arrival. Artificial G may be broadly effective as a countermeasure for many of the physiological changes of spaceflight, but from the neurovestibular perspective, it is a double-edged sword. We know that the Coriolis stimulus resulting from rotation is potentially disorienting and nauseogenic. But we don't yet know how much artificial G will be enough, nor how successfully people can adapt to a specific angular velocity and hypo G level. Development of countermeasures remains a big challenge for our neurovestibular community. Maintaining an interdisciplinary perspective is important

  17. Increasing Spontaneous Retinal Activity before Eye Opening Accelerates the Development of Geniculate Receptive Fields.

    PubMed

    Davis, Zachary W; Chapman, Barbara; Cheng, Hwai-Jong

    2015-10-28

    Visually evoked activity is necessary for the normal development of the visual system. However, little is known about the capacity for patterned spontaneous activity to drive the maturation of receptive fields before visual experience. Retinal waves provide instructive retinotopic information for the anatomical organization of the visual thalamus. To determine whether retinal waves also drive the maturation of functional responses, we increased the frequency of retinal waves pharmacologically in the ferret (Mustela putorius furo) during a period of retinogeniculate development before eye opening. The development of geniculate receptive fields after receiving these increased neural activities was measured using single-unit electrophysiology. We found that increased retinal waves accelerate the developmental reduction of geniculate receptive field sizes. This reduction is due to a decrease in receptive field center size rather than an increase in inhibitory surround strength. This work reveals an instructive role for patterned spontaneous activity in guiding the functional development of neural circuits. PMID:26511250

  18. UCLA accelerator research and development. Progress report, [November 1, 1991--July 31, 1992

    SciTech Connect

    Cline, D.B.

    1992-09-01

    This progress report covers work supported by the above DOE grant over the period November 1, 1991 to July 31, 1992. The work is a program of experimental and theoretical studies in advanced particle accelerator research and development for high energy physics applications. The program features research at particle beam facilities in the United States and includes research on novel high power sources, novel focussing systems (e.g. plasma lens), beam monitors, novel high brightness, high current gun systems, and novel flavor factories in particular the {phi} Factory.

  19. Niobium cavity development for the high-energy linac of the rare isotope accelerator

    SciTech Connect

    D. Barni; C. Pagani; P. Pierini; C. Compton; T. Grimm; W. Hartung; H. Podlech; R. York; G. Ciovati; P. Kneisel

    2001-08-01

    The Rare Isotope Accelerator (RIA) is being designed to supply an intense beam of exotic isotopes for nuclear physics research [1]. Superconducting cavities are to be used to accelerate the CW beam of heavy ions to 400 MeV per nucleon, with a beam power of up to 400 kW. Because of the varying velocity of the ion beam along the linac, a number of different types of superconducting structures are needed. The RIA linac will accelerate heavy ions over the same velocity range as the proton linac for the Spallation Neutron Source (SNS). It was decided to use the 6-cell axisymmetric 805 MHz cavities and cryostats of SNS for the downstream portion of the RIA linac, thereby saving the non-recurring development and engineering costs. For additional cost saving, it was decided to extend the SNS multi-cell axisymmetric cavity design to lower velocity, {beta} = v/c = 0.4, using the same cryostats and RF systems. Axisymmetric cavities will thus constitute about three-quarters of RIA's total accelerating voltage, and most of that voltage will be provided by cavities already developed for SNS. The axisymmetric cavities will accelerate the RIA beam from {beta} = 0.4 to {beta} = 0.72. This velocity range can be efficiently covered with two different types of 6-cell cavities, one with a geometric {beta}, {beta}{sub g}, of 0.47, and the other with a {beta}{sub g} of 0.61. The {beta}{sub g} = 0.61 cavity will be of the existing SNS design; some {beta}{sub g} = 0.81 SNS cavities may also be desired at the end of the RIA linac for acceleration of light ions above 400 MeV per nucleon. Prototypes for both {beta}{sub g} = 0.61 and {beta}{sub g} = 0.81 have been fabricated and tested [2]. The {beta}{sub g} = 0.47 cavity is the focus of the present work. The reduction in {beta}{sub g} to 0.47 results in less favourable electromagnetic and mechanical properties, and opens up the possibility of multipacting, but several groups have already designed and prototyped cavities in this range. These

  20. Soil Potassium Deficiency Reduces Cotton Fiber Strength by Accelerating and Shortening Fiber Development

    PubMed Central

    Yang, Jia-Shuo; Hu, Wei; Zhao, Wenqing; Meng, Yali; Chen, Binglin; Wang, Youhua; Zhou, Zhiguo

    2016-01-01

    Low potassium (K)-induced premature senescence in cotton has been observed worldwide, but how it affects cotton fiber properties remain unclear. We hypothesized that K deficiency affects cotton fiber properties by causing disordered fiber development, which may in turn be caused by the induction of a carbohydrate acquisition difficulty. To investigate this issue, we employed a low-K-sensitive cotton cultivar Siza 3 and a low-K-tolerant cultivar Simian 3 and planted them in three regions of different K supply. Data concerning lint yield, Pn and main fiber properties were collected from three years of testing. Soil K deficiency significantly accelerated fiber cellulose accumulation and dehydration processes, which, together with previous findings, suggests that the low-K induced carbohydrate acquisition difficulty could cause disordered fiber development by stimulating the expression of functional proteins such as CDKA (cyclin-dependent kinase). As a result, fiber strength and lint weight were reduced by up to 7.8% and 2.1%, respectively. Additional quantitative analysis revealed that the degree of accelerated fiber development negatively correlated with fiber strength. According to the results of this study, it is feasible to address the effects of soil K deficiency on fiber properties using existing cultivation strategies to prevent premature senescence of cotton plants. PMID:27350236

  1. WIPO Re:Search: Accelerating anthelmintic development through cross-sector partnerships

    PubMed Central

    Ramamoorthi, Roopa; Graef, Katy M.; Dent, Jennifer

    2014-01-01

    Neglected tropical diseases (NTDs), malaria, and tuberculosis have a devastating effect on an estimated 1.6 billion people worldwide. The World Intellectual Property Organization (WIPO) Re:Search consortium accelerates the development of new drugs, vaccines, and diagnostics for these diseases by connecting the assets and resources of pharmaceutical companies, such as compound libraries and expertise, to academic or nonprofit researchers with novel product discovery or development ideas. As the WIPO Re:Search Partnership Hub Administrator, BIO Ventures for Global Health (BVGH) fields requests from researchers, identifies Member organizations able to fulfill these requests, and helps forge mutually beneficial collaborations. Since its inception in October 2011, WIPO Re:Search membership has expanded to more than 90 institutions, including leading pharmaceutical companies, universities, nonprofit research institutions, and product development partnerships from around the world. To date, WIPO Re:Search has facilitated over 70 research agreements between Consortium Members, including 11 collaborations focused on anthelmintic drug discovery. PMID:25516832

  2. Surface water geochemical and isotopic variations in an area of accelerating Marcellus Shale gas development.

    PubMed

    Pelak, Adam J; Sharma, Shikha

    2014-12-01

    Water samples were collected from 50 streams in an area of accelerating shale gas development in the eastern U.S.A. The geochemical/isotopic characteristics show no correlation with the five categories of Marcellus Shale production. The sub-watersheds with the greatest density of Marcellus Shale development have also undergone extensive coal mining. Hence, geochemical/isotopic compositions were used to understand sources of salinity and effects of coal mining and shale gas development in the area. The data indicates that while some streams appear to be impacted by mine drainage; none appear to have received sustained contribution from deep brines or produced waters associated with shale gas production. However, it is important to note that our interpretations are based on one time synoptic base flow sampling of a few sampling stations and hence do account potential intermittent changes in chemistry that may result from major/minor spills or specific mine discharges on the surface water chemistry. PMID:25201226

  3. 98th LHCC meeting Agenda OPEN Session and CLOSED Session

    SciTech Connect

    2009-07-07

    OPEN Session on Wednesday, 8 July at 9h00-11h00 in Main Auditorium, Live webcast, followed by CLOSED Session, Conference room 160-1-009 11h20-17h00. CLOSED Session continued on Thursday, 9 July at 9h00-12h30

  4. 98th LHCC meeting Agenda OPEN Session and CLOSED Session

    ScienceCinema

    None

    2011-10-06

    OPEN Session on Wednesday, 8 July at 9h00-11h00 in Main Auditorium, Live webcast, followed by CLOSED Session, Conference room 160-1-009 11h20-17h00. CLOSED Session continued on Thursday, 9 July at 9h00-12h30

  5. Session: Reservoir Technology

    SciTech Connect

    Renner, Joel L.; Bodvarsson, Gudmundur S.; Wannamaker, Philip E.; Horne, Roland N.; Shook, G. Michael

    1992-01-01

    This session at the Geothermal Energy Program Review X: Geothermal Energy and the Utility Market consisted of five papers: ''Reservoir Technology'' by Joel L. Renner; ''LBL Research on the Geysers: Conceptual Models, Simulation and Monitoring Studies'' by Gudmundur S. Bodvarsson; ''Geothermal Geophysical Research in Electrical Methods at UURI'' by Philip E. Wannamaker; ''Optimizing Reinjection Strategy at Palinpinon, Philippines Based on Chloride Data'' by Roland N. Horne; ''TETRAD Reservoir Simulation'' by G. Michael Shook

  6. Session: Hot Dry Rock

    SciTech Connect

    Tennyson, George P. Jr.; Duchane, David V.; Ponden, Raymond F.; Brown, Donald W.

    1992-01-01

    This session at the Geothermal Energy Program Review X: Geothermal Energy and the Utility Market consisted of four presentations: ''Hot Dry Rock - Summary'' by George P. Tennyson, Jr.; ''HDR Opportunities and Challenges Beyond the Long Term Flow Test'' by David V. Duchane; ''Start-Up Operations at the Fenton Hill HDR Pilot Plant'' by Raymond F. Ponden; and ''Update on the Long-Term Flow Testing Program'' by Donald W. Brown.

  7. Development of an accelerated leach test(s) for low-level waste forms

    SciTech Connect

    Dougherty, D.R.; Fuhrmann, M.; Colombo, P.

    1985-01-01

    An accelerated leach test(s) is being developed to predict long-term leaching behavior of low-level radioactive waste (LLW) forms in their disposal environments. As necessary background, a literature survey of reported leaching mechanisms, available mathematical models and factors that affect leaching of LLW forms has been compiled. Mechanisms which have been identified include diffusion, dissolution, ion exchange, corrosion and surface effects. A computerized data base of LLW leaching data and mathematical models is being developed. The data is being used for model evaluation by curve fitting and statistical analysis according to standard procedures of statistical quality control. Long-term leach tests on portland cement, bitumen and vinyl ester-styrene (VES) polymer waste forms are underway which are designed to identify and evaluate factors that accelerate leaching without changing the mechanisms. Initial results on the effect of temperature on leachability indicate that the leach rates of cement and VES waste forms increase with increasing temperature, whereas, the leach rate of bitumen is little affected. 10 refs., 5 figs.

  8. OpenMP-accelerated SWAT simulation using Intel C and FORTRAN compilers: Development and benchmark

    NASA Astrophysics Data System (ADS)

    Ki, Seo Jin; Sugimura, Tak; Kim, Albert S.

    2015-02-01

    We developed a practical method to accelerate execution of Soil and Water Assessment Tool (SWAT) using open (free) computational resources. The SWAT source code (rev 622) was recompiled using a non-commercial Intel FORTRAN compiler in Ubuntu 12.04 LTS Linux platform, and newly named iOMP-SWAT in this study. GNU utilities of make, gprof, and diff were used to develop the iOMP-SWAT package, profile memory usage, and check identicalness of parallel and serial simulations. Among 302 SWAT subroutines, the slowest routines were identified using GNU gprof, and later modified using Open Multiple Processing (OpenMP) library in an 8-core shared memory system. In addition, a C wrapping function was used to rapidly set large arrays to zero by cross compiling with the original SWAT FORTRAN package. A universal speedup ratio of 2.3 was achieved using input data sets of a large number of hydrological response units. As we specifically focus on acceleration of a single SWAT run, the use of iOMP-SWAT for parameter calibrations will significantly improve the performance of SWAT optimization.

  9. Development of a quantitative accelerated sulphate attack test for mine backfill

    NASA Astrophysics Data System (ADS)

    Shnorhokian, Shahe

    Mining operations produce large amounts of tailings that are either disposed of in surface impoundments or used in the production of backfill to be placed underground. Their mineralogy is determined by the local geology, and it is not uncommon to come across tailings with a relatively high sulphide mineral content, including pyrite and pyrrhotite. Sulphides oxidize in the presence of oxygen and water to produce sulphate and acidity. In the concrete industry, sulphate is known to produce detrimental effects by reacting with the cement paste to produce the minerals ettringite and gypsum. Because mine backfill uses tailings and binders---including cement---it is therefore prone to sulphate attack where the required conditions are met. Currently, laboratory tests on mine backfill mostly measure mechanical properties such as strength parameters, and the study of the chemical aspects is restricted to the impact of tailings on the environment. The potential of sulphate attack in mine backfill has not been studied at length, and no tests are conducted on binders used in backfill for their resistance to attack. Current ASTM guidelines for sulphate attack tests have been deemed inadequate by several authors due to their measurement of only expansion as an indicator of attack. Furthermore, the tests take too long to perform or are restricted to cement mortars only, and not to mixed binders that include pozzolans. Based on these, an accelerated test for sulphate attack was developed in this work through modifying and compiling procedures that had been suggested by different authors. Small cubes of two different binders were fully immersed in daily-monitored sodium sulphate and sulphuric acid solutions for a total of 28 days, after 7 days of accelerated curing at 50°C. In addition, four binders were partially immersed in the same solutions for 8 days for an accelerated attack process. The two procedures were conducted in tandem with leach tests using a mixed solution of

  10. High Voltage Hall Accelerator Propulsion System Development for NASA Science Missions

    NASA Technical Reports Server (NTRS)

    Kamhawi, Hani; Haag, Thomas; Huang, Wensheng; Shastry, Rohit; Pinero, Luis; Peterson, Todd; Dankanich, John; Mathers, Alex

    2013-01-01

    NASA Science Mission Directorates In-Space Propulsion Technology Program is sponsoring the development of a 3.8 kW-class engineering development unit Hall thruster for implementation in NASA science and exploration missions. NASA Glenn Research Center and Aerojet are developing a high fidelity high voltage Hall accelerator (HiVHAc) thruster that can achieve specific impulse magnitudes greater than 2,700 seconds and xenon throughput capability in excess of 300 kilograms. Performance, plume mappings, thermal characterization, and vibration tests of the HiVHAc engineering development unit thruster have been performed. In addition, the HiVHAc project is also pursuing the development of a power processing unit (PPU) and xenon feed system (XFS) for integration with the HiVHAc engineering development unit thruster. Colorado Power Electronics and NASA Glenn Research Center have tested a brassboard PPU for more than 1,500 hours in a vacuum environment, and a new brassboard and engineering model PPU units are under development. VACCO Industries developed a xenon flow control module which has undergone qualification testing and will be integrated with the HiVHAc thruster extended duration tests. Finally, recent mission studies have shown that the HiVHAc propulsion system has sufficient performance for four Discovery- and two New Frontiers-class NASA design reference missions.

  11. Development and use of molecular markers to accelerate peanut cultivar development

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Close cooperation between conventional plant breeders and molecular geneticists will be needed to efficiently and effectively utilize modern genetic tools in the development of peanut cultivars. We have used this approach at Tifton to develop molecular markers for resistance to the peanut root-knot...

  12. Effects of Prenatal Irradiation with an Accelerated Heavy-Ion Beam on Postnatal Development in Rats

    NASA Astrophysics Data System (ADS)

    Wang, B.; Murakami, M.; Eguchi-Kasai, K.; Nojima, K.; Shang, Y.; Tanaka, K.; Fujita, K.; Coffigny, H.; Hayata, I.

    Effects on postnatal neurophysiological development in offspring were studied following exposure of pregnant Wistar rats to accelerated neon-ion beams with a LET value of about 30 keV mu m at a dose range from 0 1 Gy to 2 0Gy on the 15th day of gestation The age at which four physiologic markers appeared and five reflexes were acquired was examined prior to weaning Gain in body weight was monitored until the offspring were 3 months old Male offspring were evaluated as young adults using two behavioral tests The effects of X-rays at 200 kVp measured for the same biological end points were studied for comparison Our previous study on carbon-ion beams with a LET value of about 13 keV mu m was also cited to elucidate a possible LET-related effect For most of the endpoints at early age significant alteration was even observed in offspring prenatally received 0 1 Gy of accelerated neon ions while neither X rays nor carbon-ions under the same dose resulted in such a significant alteration compared to that from the sham-irradiated dams All offspring whose mothers received 2 0 Gy died prior to weaning Offspring from dams irradiated with accelerated neon ions generally showed higher incidences of prenatal death and preweaning mortality markedly delayed accomplishment in their physiological markers and reflexes and gain in body weight compared to those exposed to X-rays or carbon ions at doses of 0 1 to 1 5 Gy Significantly reduced ratios of main organ weight to body weight at postnatal ages of 30 60 and 90 days were also observed

  13. MALVAC 2012 scientific forum: accelerating development of second-generation malaria vaccines

    PubMed Central

    2012-01-01

    The World Health Organization (WHO) convened a malaria vaccines committee (MALVAC) scientific forum from 20 to 21 February 2012 in Geneva, Switzerland, to review the global malaria vaccine portfolio, to gain consensus on approaches to accelerate second-generation malaria vaccine development, and to discuss the need to update the vision and strategic goal of the Malaria Vaccine Technology Roadmap. This article summarizes the forum, which included reviews of leading Plasmodium falciparum vaccine candidates for pre-erythrocytic vaccines, blood-stage vaccines, and transmission-blocking vaccines. Other major topics included vaccine candidates against Plasmodium vivax, clinical trial site capacity development in Africa, trial design considerations for a second-generation malaria vaccine, adjuvant selection, and regulatory oversight functions including vaccine licensure. PMID:23140365

  14. Accelerating Development of EV Batteries Through Computer-Aided Engineering (Presentation)

    SciTech Connect

    Pesaran, A.; Kim, G. H.; Smith, K.; Santhanagopalan, S.

    2012-12-01

    The Department of Energy's Vehicle Technology Program has launched the Computer-Aided Engineering for Automotive Batteries (CAEBAT) project to work with national labs, industry and software venders to develop sophisticated software. As coordinator, NREL has teamed with a number of companies to help improve and accelerate battery design and production. This presentation provides an overview of CAEBAT, including its predictive computer simulation of Li-ion batteries known as the Multi-Scale Multi-Dimensional (MSMD) model framework. MSMD's modular, flexible architecture connects the physics of battery charge/discharge processes, thermal control, safety and reliability in a computationally efficient manner. This allows independent development of submodels at the cell and pack levels.

  15. Summary report: Working Group 2 on {open_quotes}Plasma Based Acceleration Concepts{close_quotes}

    SciTech Connect

    Leemans, W.P.; Esarey, E.; Esarey, E.

    1999-07-01

    A summary of the talks, papers and discussion sessions presented in the Working Group on Plasma Based Acceleration Concepts is given within the context of the progress towards a 1 GeV laser driven accelerator module. The topics covered within the Working Group were self-modulated laser wakefield acceleration, standard laser wakefield acceleration, plasma beatwave acceleration, laser guiding and wake excitation in plasma channels, plasma wakefield acceleration, plasma lenses and optical injection techniques for laser wakefield accelerators. An overview will be given of the present status of experimental and theoretical progress as well as an outlook towards the future physics and technological challenges for the development of an optimized accelerator module. {copyright} {ital 1999 American Institute of Physics.}

  16. Nonlinear development of strong current-driven instabilities and selective acceleration of ^3He ions

    NASA Astrophysics Data System (ADS)

    Toida, Mieko; Okumura, Hayato

    2003-10-01

    In some solar flares, the abundance of high-energy ^3He ions is extremely increased. As a mechanism for these ^3He rich events, current-driven instabilities are believed to be important. Nonlinear development of the strong current-driven instabilities and associated energy transfer to ^3He ions are studied theoretically and numerically [1]. First, by means of a two-dimensional, electrostatic, particle simulation code, it is demonstrated that ^3He ions are selectively accelerated by fundamental H cyclotron waves with frequencies ω ≃ 2Ω_3He (Ω_3He is the cyclotron frequency of ^3He). Then, from the analysis of the dispersion relation of these waves, it is found that the ω ≃ 2 Ω_ 3He waves have the greatest growth rate, if Te > 10 T_H. Energies of the ^3He ions are also discussed. Theoretical expression for the maximum ^3He energy is presented, which is in good agreement with the simulation results. Based on this theory, it is shown that when the initial electron drift energy is of the order of 10 keV, many ^3He ions can be accelerated to energies of the order of MeV/n. [1] M. Toida and H. Okumura, J. Phys. Soc. Jpn. 72,1098 (2003)

  17. Development of Wind-and-React Bi-2212 Accelerator Magnet Technology

    SciTech Connect

    Cheng, Daniel; Dietderich, Daniel R.; English, C.D.; Felice, Helene; Hannaford, Charles R.; Prestemon, Soren O.; Sabbi, GianLuca; Scanlan, Ron M.; Hikichi, Y.; Nishioka, J.; Hasegawa, T.; Godeke, A.

    2007-06-01

    We report on the progress in our R&D program, targeted to develop the technology for the application of Bi{sub 2}Sr{sub 2}CaCu{sub 2}O{sub x} (Bi-2212) in accelerator magnets. The program uses subscale coils, wound from insulated cables, to study suitable materials, heat treatment homogeneity, stability, and effects of magnetic field and thermal and electro-magnetic loads. We have addressed material and reaction related issues and report on the fabrication, heat treatment, and analysis of subscale Bi-2212 coils. Such coils can carry a current on the order of 5000 A and generate, in various support structures, magnetic fields from 2.6 to 9.9 T. Successful coils are therefore targeted towards a hybrid Nb{sub 3}Sn-HTS magnet which will demonstrate the feasibility of Bi-2212 for accelerator magnets, and open a new magnetic field realm, beyond what is achievable with Nb{sub 3}Sn.

  18. Recent advances in the development of high average power induction accelerators for industrial and environmental applications

    SciTech Connect

    Neau, E.L.

    1994-09-01

    Short-pulse accelerator technology developed during the early 1960`s through the late 1980`s is being extended to high average power systems capable of use in industrial and environmental applications. Processes requiring high dose levels and/or high volume throughput will require systems with beam power levels from several hundreds of kilowatts to megawatts. Beam accelerating potentials can range from less than 1 MeV to as much as 10 MeV depending on the type of beam, depth of penetration required, and the density of the product being treated. This paper addresses the present status of a family of high average power systems, with output beam power levels up to 200 kW, now in operation that use saturable core switches to achieve output pulse widths of 50 to 80 nanoseconds. Inductive adders and field emission cathodes are used to generate beams of electrons or x-rays at up to 2.5 MeV over areas of 1000 cm{sup 2}. Similar high average power technology is being used at {le} 1 MeV to drive repetitive ion beam sources for treatment of material surfaces over 100`s of cm{sup 2}.

  19. Development of an H- ion source for Japan Proton Accelerator Research Complex upgradea)

    NASA Astrophysics Data System (ADS)

    Ohkoshi, K.; Namekawa, Y.; Ueno, A.; Oguri, H.; Ikegami, K.

    2010-02-01

    A cesium (Cs) free H- ion source driven with a lanthanum hexaboride (LaB6) filament was adopted as an ion source for the first stage of the Japan Proton Accelerator Research Complex (J-PARC). At present, the maximum H- ion current produced by the ion source is 38 mA, using which J-PARC can produce a proton beam power of 0.6 MW by accelerating it with the 181 MeV linac and the 3 GeV rapid cycling synchrotron. In order to satisfy the beam power of 1 MW required for the second stage of the J-PARC in the near future, we have to increase the ion current to more than 60 mA. Therefore, we have started to develop a Cs-seeded ion source by adding an external Cs-seeding system to a J-PARC test ion source that has a structure similar to that of the J-PARC ion source except for the fact that the plasma chamber is slightly larger. As a result, a H- ion current of more than 70 mA was obtained from the ion source using a tungsten filament instead of a LaB6 filament with a low arc discharge power of 15 kW (100 V, 150 A).

  20. The development of seismic guidelines for the Stanford Linear Accelerator Center

    SciTech Connect

    Huggins, R.

    1996-08-01

    This paper describes the development of Seismic Guidelines for the Stanford Linear Accelerator Center (SLAC). Although structures have always been built conservatively, SLAC management decided to review and update their seismic guidelines. SLAC is about mid-way between the epicenters of the 8.3 Richter magnitude 1906 San Francisco and the 7.2 Loma Prieta Earthquakes. The west end of the two mile long electron/positron particle accelerator lies a half mile from the large San Andreas Fault. Suggestions for seismic planning processes were solicited from local computer manufacturing firms, universities, and federal laboratories. A Committee of the various stakeholders in SLAC`s seismic planning retained an internationally known Seismic Planning Consultant and reviewed relevant standards and drafted Guidelines. A panel of seismic experts was convened to help define the hazard, site response spectra, probabilistic analysis of shaking, and near field effects. The Facility`s structures were assigned to seismic classes of importance, and an initial assessment of a sample of a dozen buildings conducted. This assessment resulted in emergency repairs to one structure, and provided a {open_quotes}reality basis{close_quotes} for establishing the final Guidelines and Administrative Procedures, and a program to evaluate remaining buildings, shielding walls, tunnels, and other special structures.

  1. New options for developing of nuclear energy using an accelerator-driven reactor

    SciTech Connect

    Takahashi, Hiroshi

    1997-09-01

    Fissile fuel can be produced at a high rate using an accelerator-driven Pu-fueled subcritical fast reactor. Thus, the necessity of early introduction of the fast reactor can be moderated. High reliability of the proton accelerator, which is essential to implementing an accelerator-driven reactor in the nuclear energy field can be achieved by a slight extension of the accelerator`s length, with only a small economical penalty. Subcritical operation provides flexible nuclear energy options including high neutron economy producing the fuel, transmuting high-level wastes, such as minor actinides, and of converting efficiently the excess Pu and military Pu into proliferation-resistant fuel.

  2. Analytical Validation of Accelerator Mass Spectrometry for Pharmaceutical Development: the Measurement of Carbon-14 Isotope Ratio.

    SciTech Connect

    Keck, B D; Ognibene, T; Vogel, J S

    2010-02-05

    Accelerator mass spectrometry (AMS) is an isotope based measurement technology that utilizes carbon-14 labeled compounds in the pharmaceutical development process to measure compounds at very low concentrations, empowers microdosing as an investigational tool, and extends the utility of {sup 14}C labeled compounds to dramatically lower levels. It is a form of isotope ratio mass spectrometry that can provide either measurements of total compound equivalents or, when coupled to separation technology such as chromatography, quantitation of specific compounds. The properties of AMS as a measurement technique are investigated here, and the parameters of method validation are shown. AMS, independent of any separation technique to which it may be coupled, is shown to be accurate, linear, precise, and robust. As the sensitivity and universality of AMS is constantly being explored and expanded, this work underpins many areas of pharmaceutical development including drug metabolism as well as absorption, distribution and excretion of pharmaceutical compounds as a fundamental step in drug development. The validation parameters for pharmaceutical analyses were examined for the accelerator mass spectrometry measurement of {sup 14}C/C ratio, independent of chemical separation procedures. The isotope ratio measurement was specific (owing to the {sup 14}C label), stable across samples storage conditions for at least one year, linear over 4 orders of magnitude with an analytical range from one tenth Modern to at least 2000 Modern (instrument specific). Further, accuracy was excellent between 1 and 3 percent while precision expressed as coefficient of variation is between 1 and 6% determined primarily by radiocarbon content and the time spent analyzing a sample. Sensitivity, expressed as LOD and LLOQ was 1 and 10 attomoles of carbon-14 (which can be expressed as compound equivalents) and for a typical small molecule labeled at 10% incorporated with {sup 14}C corresponds to 30 fg

  3. Residual acceleration data on IML-1: Development of a data reduction and dissemination plan

    NASA Technical Reports Server (NTRS)

    Rogers, Melissa J. B.; Alexander, J. Iwan D.; Wolf, Randy

    1992-01-01

    The need to record some measure of the low-gravity environment of an orbiting space vehicle was recognized at an early stage of the U.S. Space Program. Such information was considered important for both the assessment of an astronaut's physical condition during and after space missions and the analysis of the fluid physics, materials processing, and biological sciences experiments run in space. Various measurement systems were developed and flown on space platforms beginning in the early 1970's. Similar in concept to land based seismometers that measure vibrations caused by earthquakes and explosions, accelerometers mounted on orbiting space vehicles measure vibrations in and of the vehicle due to internal and external sources, as well as vibrations in a sensor's relative acceleration with respect to the vehicle to which it is attached. The data collected over the years have helped to alter the perception of gravity on-board a space vehicle from the public's early concept of zero-gravity to the science community's evolution of thought from microgravity to milligravity to g-jitter or vibrational environment. Since the advent of the Shuttle Orbiter Program, especially since the start of Spacelab flights dedicated to scientific investigations, the interest in measuring the low-gravity environment in which experiments are run has increased. This interest led to the development and flight of numerous accelerometer systems dedicated to specific experiments. It also prompted the development of the NASA MSAD-sponsored Space Acceleration Measurement System (SAMS). The first SAMS units flew in the Spacelab on STS-40 in June 1991 in support of the first Spacelab Life Sciences mission (SLS-1). SAMS is currently manifested to fly on all future Spacelab missions.

  4. Accelerated development of Zr-containing new generation ferritic steels for advanced nuclear reactors

    SciTech Connect

    Tan, Lizhen; Yang, Ying; Sridharan, K.

    2015-12-01

    The mission of the Nuclear Energy Enabling Technologies (NEET) program is to develop crosscutting technologies for nuclear energy applications. Advanced structural materials with superior performance at elevated temperatures are always desired for nuclear reactors, which can improve reactor economics, safety margins, and design flexibility. They benefit not only new reactors, including advanced light water reactors (LWRs) and fast reactors such as the sodium-cooled fast reactor (SFR) that is primarily designed for management of high-level wastes, but also life extension of the existing fleet when component exchange is needed. Developing and utilizing the modern materials science tools (experimental, theoretical, and computational tools) is an important path to more efficient alloy development and process optimization. The ultimate goal of this project is, with the aid of computational modeling tools, to accelerate the development of Zr-bearing ferritic alloys that can be fabricated using conventional steelmaking methods. The new alloys are expected to have superior high-temperature creep performance and excellent radiation resistance as compared to Grade 91. The designed alloys were fabricated using arc-melting and drop-casting, followed by hot rolling and conventional heat treatments. Comprehensive experimental studies have been conducted on the developed alloys to evaluate their hardness, tensile properties, creep resistance, Charpy impact toughness, and aging resistance, as well as resistance to proton and heavy ion (Fe2+) irradiation.

  5. PPM focused X-band klystron development at the Stanford Linear Accelerator Center

    SciTech Connect

    Sprehn, D.; Caryotakis, G.; Eppley, K.; Phillips, R.M.

    1996-07-01

    X-band klystrons capable of 50 MW and utilizing Periodic Permanent Magnet (PPM) focusing are undergoing design and fabrication at the Stanford Linear Accelerator Center (SLAC). The klystron development is part of an effort to realize components necessary for the construction of the Next Linear Collider (NLC). The first klystron to be tested this year has a 0.6 microK beam at 465 kV, a 5 cells traveling wave output structure and a predicted efficiency of 63%. A 465 kV, 190 A beam stick with 12 periods of PPM focusing has recently operated to verify the gun optics and transmission of the beam in the absence of rf bunching. Beam transmission greater than 99.8% has been measured. Design and simulation of the beam stick and klystron are discussed, along with performance of the beam stick under confined flow and shielded conditions.

  6. Development of a 15 T $Nb_3Sn$ Accelerator Dipole Demonstrator at Fermilab

    SciTech Connect

    Novitski, I.; Andreev, N.; Barzi, E.; Carmichael, J.; Kashikhin, V. V.; Turrion, D.; Yu, M.; Zlobin, A. V.

    2015-01-01

    100 TeV scale Hadron Collider (HC) with a nominal operation field of at least 15 T is being considered for the post-LHC era, which requires using the $Nb_3Sn$ technology. Practical demonstration of this field level in an accelerator-quality magnet and substantial reduction of the magnet costs are the key conditions for realization of such a machine. FNAL has started the development of a 15 T Nb3Sn dipole demonstrator for a 100 TeV scale HC. The magnet design is based on 4-layer shell type coils, graded between the inner and outer layers to maximize the performance and reduce the cost. The experience gained during the Nb3Sn magnet R&D is applied to different aspects of the magnet design. This paper describes the magnetic and structural designs and parameters of the 15 T Nb3Sn dipole and the steps towards the demonstration model fabrication.

  7. Development of a Lorentz Force Accelerator Injector for the VASIMR Engine

    NASA Astrophysics Data System (ADS)

    Glover, T. W.; Chan, A. A.; Díaz, F. R. Chang; Squire, J.

    1998-11-01

    We report on the effort to develop a Lorentz Force Accelerator for use as a plasma injector for the VASIMR(Variable Specific Impulse Magnetoplasma Rocket) engine. Advantages of the LFA, also known as a magnetoplasmadynamic thruster, include simplicity of construction, the ability to use a wide variety of propellant gases without modification, and minimal power processing requirements. As a plasma source for the VASIMR engine, its feature of ejecting plasma in a tightly collimated jet allows it to inject plasma through the loss cone of the VASIMR magnetic field into the engine's central cell. This passage from weak to strong magnetic field regions may result in a desirable increase in plasma density in the central cell. Work to date has focused on achieving reliable start-up and steady-state operation.

  8. Development of a Nb 3Sn multifilamentary wire for accelerator magnet applications

    NASA Astrophysics Data System (ADS)

    Durante, M.; Bredy, P.; Devred, A.; Otmani, R.; Reytier, M.; Schild, T.; Trillaud, F.

    2001-05-01

    CEA/Saclay and Alstom/MSA have carried out a program to develop a Nb 3Sn multifilamentary wire for accelerator magnet applications relying on the internal-tin process. The main wire specifications are: an overall diameter of 0.825 mm, a critical current larger than 405 A at 4.2 K and 7 T, hysteresis losses lower than 450 mJ/cm 3 for a±3 T trapezoidal cycle, and a copper-to-non-copper ratio greater than 1. The last phase of the optimization program was based on four different strands and we present here the results of the characterization tests, including residual resistivity ratio, critical current and AC loss measurements.

  9. Development of Wind-and-React Bi-2212 Accelerator MagnetTechnology

    SciTech Connect

    Godeke, A.; Cheng, D.; Dietderich, D.R.; English, C.D.; Felice,H.; Hannaford, C.R.; Prestemon, S.O.; Sabbi, G.; Scanlan, R.M.; Hikichi,Y.; Nishioka, J.; Hasegawa, T.

    2007-08-28

    We report on the progress in our R&D program, targetedto develop the technology for the application of Bi2Sr2CaCu2Ox (Bi-2212)in accelerator magnets. The program uses subscale coils, wound frominsulated cables, to study suitable materials, heat treatmenthomogeneity, stability, and effects ofmagnetic field and thermal andelectro-magnetic loads. We have addressed material and reaction relatedissues and report onthe fabrication, heat treatment, and analysis ofsubscale Bi-2212 coils. Such coils can carry a current on the order of5000 A and generate, in various support structures, magnetic fields from2.6 to 9.9 T. Successful coils are therefore targeted towards a hybridNb3Sn-HTS magnet which will demonstrate the feasibility of Bi-2212 foraccelerator magnets, and open a new magnetic field realm, beyond what isachievable with Nb3Sn.

  10. Working session 2: Tubing inspection

    SciTech Connect

    Guerra, J.; Tapping, R.L.

    1997-02-01

    This session was attended by delegates from 10 countries, and four papers were presented. A wide range of issues was tabled for discussion. Realizing that there was limited time available for more detailed discussion, three topics were chosen for the more detailed discussion: circumferential cracking, performance demonstration (to focus on POD and sizing), and limits of methods. Two other subsessions were organized: one dealt with some challenges related to the robustness of current inspection methods, especially with respect to leaving cracked tubes in service, and the other with developing a chart of current NDE technology with recommendations for future development. These three areas are summarized in turn, along with conclusions and/or recommendations. During the discussions there were four presentations. There were two (Canada, Japan) on eddy current probe developments, both of which addressed multiarray probes that would detect a range of flaws, one (Spain) on circumferential crack detection, and one (JRC, Petten) on the recent PISC III results.

  11. Self-accelerated development of salt karst during flash floods along the Dead Sea Coast, Israel

    NASA Astrophysics Data System (ADS)

    Avni, Yoav; Lensky, Nadav; Dente, Elad; Shviro, Maayan; Arav, Reuma; Gavrieli, Ittai; Yechieli, Yoseph; Abelson, Meir; Lutzky, Hallel; Filin, Sagi; Haviv, Itai; Baer, Gidon

    2016-01-01

    We document and analyze the rapid development of a real-time karst system within the subsurface salt layers of the Ze'elim Fan, Dead Sea, Israel by a multidisciplinary study that combines interferometric synthetic aperture radar and light detection and ranging measurements, sinkhole mapping, time-lapse camera monitoring, groundwater level measurements and chemical and isotopic analyses of surface runoff and groundwater. The >1 m/yr drop of Dead Sea water level and the subsequent change in the adjacent groundwater system since the 1960s resulted in flushing of the coastal aquifer by fresh groundwater, subsurface salt dissolution, gradual land subsidence and formation of sinkholes. Since 2010 this process accelerated dramatically as flash floods at the Ze'elim Fan were drained by newly formed sinkholes. During and immediately after these flood events the dissolution rates of the subsurface salt layer increased dramatically, the overlying ground surface subsided, a large number of sinkholes developed over short time periods (hours to days), and salt-saturated water resurged downstream. Groundwater flow velocities increased by more than 2 orders of magnitudes compared to previously measured velocities along the Dead Sea. The process is self-accelerating as salt dissolution enhances subsidence and sinkhole formation, which in turn increase the ponding areas of flood water and generate additional draining conduits to the subsurface. The rapid terrain response is predominantly due to the highly soluble salt. It is enhanced by the shallow depth of the salt layer, the low competence of the newly exposed unconsolidated overburden and the moderate topographic gradients of the Ze'elim Fan.

  12. Accelerated renal disease is associated with the development of metabolic syndrome in a glucolipotoxic mouse model

    PubMed Central

    Martínez-García, Cristina; Izquierdo, Adriana; Velagapudi, Vidya; Vivas, Yurena; Velasco, Ismael; Campbell, Mark; Burling, Keith; Cava, Fernando; Ros, Manuel; Orešič, Matej; Vidal-Puig, Antonio; Medina-Gomez, Gema

    2012-01-01

    SUMMARY Individuals with metabolic syndrome are at high risk of developing chronic kidney disease (CKD) through unclear pathogenic mechanisms. Obesity and diabetes are known to induce glucolipotoxic effects in metabolically relevant organs. However, the pathogenic role of glucolipotoxicity in the aetiology of diabetic nephropathy is debated. We generated a murine model, the POKO mouse, obtained by crossing the peroxisome proliferator-activated receptor gamma 2 (PPARγ2) knockout (KO) mouse into a genetically obese ob/ob background. We have previously shown that the POKO mice showed: hyperphagia, insulin resistance, hyperglycaemia and dyslipidaemia as early as 4 weeks of age, and developed a complete loss of normal β-cell function by 16 weeks of age. Metabolic phenotyping of the POKO model has led to investigation of the structural and functional changes in the kidney and changes in blood pressure in these mice. Here we demonstrate that the POKO mouse is a model of renal disease that is accelerated by high levels of glucose and lipid accumulation. Similar to ob/ob mice, at 4 weeks of age these animals exhibited an increased urinary albumin:creatinine ratio and significantly increased blood pressure, but in contrast showed a significant increase in the renal hypertrophy index and an associated increase in p27Kip1 expression compared with their obese littermates. Moreover, at 4 weeks of age POKO mice showed insulin resistance, an alteration of lipid metabolism and glomeruli damage associated with increased transforming growth factor beta (TGFβ) and parathyroid hormone-related protein (PTHrP) expression. At this age, levels of proinflammatory molecules, such as monocyte chemoattractant protein-1 (MCP-1), and fibrotic factors were also increased at the glomerular level compared with levels in ob/ob mice. At 12 weeks of age, renal damage was fully established. These data suggest an accelerated lesion through glucolipotoxic effects in the renal pathogenesis in POKO mice

  13. Development of a four cavity second-harmonic gyroklystron as driver for a linear accelerator

    NASA Astrophysics Data System (ADS)

    Gouveia, Emmanuel Steve

    Gyroklystrons are microwave amplifiers that combine the multi-cavity configuration of a klystron with the energy extraction mechanism of the cyclotron maser instability. These devices have been studied at the University of Maryland for several years. This work is focused on the development of a 17.14 GHz four-cavity frequency-doubling gyroklystron circuit. This device was designed specifically to drive a high gradient linear accelerator recently developed by the Haimson Corporation. The gyroklystron was designed using the code MAGYKL, yielding a predicted output power of 87 MW for an input drive power of 250 W, with a velocity pitch ratio (alpha) of 1.4. The tube was later fabricated, and underwent a series of experimental tests to evaluate its performance. The highest peak power observed was 18.5 +/- 1.7 MW, corresponding to an efficiency of 7.0% and a gain of 24.0 dB. This result fell short of the theoretical design, yet it was consistent with the low value of the velocity pitch ratio (alpha = 0.85) realized in the experiments. This limitation on alpha was linked to the onset of instabilities in the input cavity. The ultimate cause of these instabilities was the thermal non-uniformity in the emitter of our electron gun, which led to a significant variation (approximately 50%) of the current density across the beam. In order to remedy this problem, we have radically redesigned the input cavity, changing both its geometry and Q factor. These measures should dramatically reduce the probability of instabilities, thus allowing us to remove the experimental limitations imposed on alpha. This new design is presented here. We also describe advanced designs of an output cavity with radial power extraction, and a compact circular to rectangular mode converter. A detailed description of the present experimental setup is given, along with an overview of the power transport system necessary to feed the accelerator with output power from the gyroklystron.

  14. Introduction to the Special Session on Thermal Remote Sensing Data for Earth Science Research: The Critical Need for Continued Data Collection and Development of Future Thermal Satellite Sensors

    NASA Technical Reports Server (NTRS)

    Quattrochi, Dale a.; Luvall, Jeffrey C.; Anderson, Martha; Hook, Simon

    2006-01-01

    There is a rich and long history of thermal infrared (TIR) remote sensing data for multidisciplinary Earth science research. The continuity of TIR data collection, however, is now in jeopardy given there are no planned future Earth observing TIR remote sensing satellite systems with moderately high spatial resolutions to replace those currently in orbit on NASA's Terra suite of sensors. This session will convene researchers who have actively worked in the field of TIR remote sensing to present results that elucidate the importance of thermal remote sensing to the wider Earth science research community. Additionally, this session will also exist as a forum for presenting concepts and ideas for new thermal sensing systems with high spatial resolutions for future Earth science satellite missions, as opposed to planned systems such as the Visible/Infrared Imager/Radiometer (VIIRS) suite of sensors on the National Polar-orbiting Operational Environmental Satellite System (NPOESS) that will collect TIR data at very coarse iairesolutions.

  15. An accelerated remedial strategy developed for J-Field, Aberdeen Proving Ground, Maryland

    SciTech Connect

    Yuen, C.R.; Martino, L.; Patton, T.; Wrobel, J.

    1995-06-01

    For an installation with many disposal sites and multiple contaminant sources, successful remediation at minimum cost can be complicated by insufficient geologic and hydrogeologic information, incomplete records of historical disposal activities, and uncertainty about the effectiveness of different investigative methods. To reduce these uncertainties and to increase the probability of successful remediation at minimum cost, a ``Phased and pilot`` accelerated remedial strategy has been developed for the J-Field area of Aberdeen Proving Ground, Maryland. The strategy includes four phases. First, the most contaminated site is selected as a pilot for detailed investigation. Second, the most contaminated areas within the pilot site are chosen as a pilot source area for interim action study, and a remedial action is developed to remove the primary contaminant sources. The subsequent sitewide investigation uses the effective tools developed in the first phase. Third, a cleanup operation is initiated in the pilot source area, while a sitewide feasibility study is developed by taking advantage of lessons learned in the interim action. Fourth, a sitewide cleanup operation proceeds.

  16. Working session 1: Tubing degradation

    SciTech Connect

    Kharshafdjian, G.; Turluer, G.

    1997-02-01

    A general introductory overview of the purpose of the group and the general subject area of SG tubing degradation was given by the facilitator. The purpose of the session was described as to {open_quotes}develop conclusions and proposals on regulatory and technical needs required to deal with the issues of SG tubing degradation.{close_quotes} Types, locations and characteristics of tubing degradation in steam generators were briefly reviewed. The well-known synergistic effects of materials, environment, and stress and strain/strain rate, subsequently referred to by the acronym {open_quotes}MESS{close_quotes} by some of the group members, were noted. The element of time (i.e., evolution of these variables with time) was emphasized. It was also suggested that the group might want to consider the related topics of inspection capabilities, operational variables, degradation remedies, and validity of test data, and some background information in these areas was provided. The presentation given by Peter Millet during the Plenary Session was reviewed; Specifically, the chemical aspects and the degradation from the secondary side of the steam generator were noted. The main issues discussed during the October 1995 EPRI meeting on secondary side corrosion were reported, and a listing of the potential SG tube degradations was provided and discussed.

  17. Development of High-Gradient Dielectric Laser-Driven Particle Accelerator Structures

    SciTech Connect

    Byer, Robert L.

    2013-11-07

    The thrust of Stanford's program is to conduct research on high-gradient dielectric accelerator structures driven with high repetition-rate, tabletop infrared lasers. The close collaboration between Stanford and SLAC (Stanford Linear Accelerator Center) is critical to the success of this project, because it provides a unique environment where prototype dielectric accelerator structures can be rapidly fabricated and tested with a relativistic electron beam.

  18. Session: Discussion of Research Needs

    SciTech Connect

    anon.

    2004-09-01

    This final session at the Wind Energy and Birds/Bats workshop was lead by a facilitator who asked participants for their overall reaction to the research that had been presented during the workshop. Questions addressed by workshop participants included: how do you develop trust and confidence in the research, what are some of the specific gaps in our understanding of wind energy's impact on birds and bats; how do we prioritize and proceed with closing the data/research gaps; how do we connect the dots and bring various research and mapping efforts together; given gaps in the data, what are the critical questions we need to answer to make project decisions now; and, how do we track/influence the policies that will shape wind energy development. Conclusions reached regarding these questions are included in summary form.

  19. Development of integrated superconducting quadrupole doublet modules for operation in the SIS100 accelerator

    NASA Astrophysics Data System (ADS)

    Meier, J.; Bleile, A.; Ceballos Velasco, J.; Fischer, E.; Hess, G.; Macavei, J.; Spiller, P.

    2015-12-01

    The FAIR project (Facility for Antiproton and Ion Research) evolves and builds an international accelerator- and experimental facility for basic research activities in various fields of modern physics. Within the course of this project, integrated quadrupole doublet modules are in development. The quadrupole doublet modules provide a pair of superconducting main quadrupoles (focusing and defocusing), corrector magnets, cryogenic collimators and beam position monitors as integrated sets of ion-optical elements. Furthermore LHe cooled beam pipes and vacuum cold-warm transitions are used as ultra-high vacuum components for beam transportation. Superconducting bus bars are used for 13 kA current supply of the main quadrupole magnets. All components are integrated as one common cold mass into one cryostat. High temperature super conductor local current leads will be applied for the low current supply of corrector magnets. The quadrupole doublet modules will be operated in the SIS100 heavy ion accelerator, the core component of the FAIR project. A first version of a corrector magnet has already been manufactured at the Joint Institute for Nuclear Research (JINR), Russia, and is now ready for testing. The ion-optical lattice structure of SIS100 requires multiple configurations of named components. Eleven different configurations, organized in four categories, provide the required quadrupole doublet module setups. The high integration level of multiple ion-optical, mechanical and cryogenic functions, based on requirements of operation safety, is leading towards a sophisticated mechanical structure and cooling solution, to satisfy the demanding requirements on position preservation during thermal cycling. The mechanical and cryogenic design solutions will be discussed.

  20. Accelerating the development of improved analgesic treatments: the ACTION public-private partnership.

    PubMed

    Dworkin, Robert H; Turk, Dennis C

    2011-07-01

    There has been considerable progress identifying pathophysiologic mechanisms of neuropathic pain, but analgesic medications with improved efficacy, safety, and tolerability still represent an unmet public health need. Numerous treatments examined in recent randomized clinical trials (RCTs) have failed to show efficacy for neuropathic pain, including treatments that had previously demonstrated efficacy. This suggests that at least some negative results reflect limited assay sensitivity of RCTs to distinguish efficacious treatments from placebo. Patient characteristics, clinical trial research designs and methods, outcome measures, approaches to data analysis, and statistical power may all play a role in accounting for difficulties in demonstrating the benefits of efficacious analgesic treatments vs placebo. The identification of specific clinical trial characteristics associated with assay sensitivity in existing data has the potential to provide an evidence-based approach to the design of analgesic clinical trials. The US Food and Drug Administration recently launched the Analgesic Clinical Trial Innovations, Opportunities, and Networks (ACTION) public-private partnership, which is designed to facilitate the discovery and development of analgesics with improved efficacy, safety, and tolerability for acute and chronic pain conditions. ACTION will establish a collaborative effort to prioritize research objectives, develop a standardized analgesic database platform, and conduct methodologically focused studies to increase the assay sensitivity and efficiency of analgesic clinical trials. The results of these activities have the potential to inform and accelerate the development of improved pain management interventions of all types, not just pharmacologic treatments. PMID:21752182

  1. Three featured plenary sessions

    NASA Astrophysics Data System (ADS)

    2012-07-01

    The conference included three plenary sessions. The plenary on Governance, Security, Economy, and the Ecosystem of the Changing Arctic featured Vera Alexander, president, Arctic Research Consortium of the U.S.; Alan Thornhill, chief environmental officer, U.S. Department of the Interior's Bureau of Ocean Energy Management; and Fran Ulmer, chair, U.S. Arctic Research Commission. A plenary on the U.N. Convention on the Law of the Sea featured Ambassador David Balton, deputy assistant secretary for oceans and fisheries, U.S. Department of State; and Rear Admiral Frederick Kenney Jr., judge advocate general and chief counsel, U.S. Coast Guard. The plenary on Science and the 21st Century featured Phil Keslin, chief technology officer, small lab within Google.

  2. Nutrition Session Summary

    NASA Technical Reports Server (NTRS)

    Lane, Helen; Stein, T. P.

    1999-01-01

    Nutrition deficiencies affect multiple systems including muscle, bone, cardiovascular, renal, and gastrointestinal. Humans require many nutrients, ranging from the macronutrients (water, protein, energy sources) to micronutrients (minerals, vitamins). The ability to withstand shortfalls in intake of individual nutrients ranges from one or two days (e.g., water) to weeks (energy, protein, potassium) and months (some vitamins, minerals). In addition to putting humans at risk for nutrition deficiencies, space flight may also change the absorption, hence the pharmacodynamics, of several important medications. Papers given in this session dealt with all of these nutritional and pharmacological factors related to space flight: (1) Protein metabolism and muscle formation. (2) Pharmacodynamics. (3) Calcium metabolism and bone formation/resorption. and (4) Fluid and electrolytes.

  3. The development of a TESLA recirculator with superconducting accelerating structures in Ukraine

    NASA Astrophysics Data System (ADS)

    Guk, I. S.; Dovbnya, A. N.

    2008-12-01

    The recirculator project, which is to be built at the National Science Center, Kharkov Institute of Physics and Technology (NSC KIPT), is presented. The basic solutions incorporated in the design are given. The TESLA superconducting section is chosen as the accelerating structure of an accelerating complex.

  4. Using Qualitative Observation To Document Group Processes in Accelerated Schools Training: Techniques and Results.

    ERIC Educational Resources Information Center

    McFarland, Katherine; Batten, Constance

    This paper describes the use of qualitative observation techniques for gathering and analyzing data related to group processes during an Accelerated Schools Model training session. The purposes for this research were to observe the training process in order better to facilitate present continuation and future training, to develop questions for…

  5. Development of a dual-pulse RF driver for an S-band (= 2856 MHz) RF electron linear accelerator

    NASA Astrophysics Data System (ADS)

    Cha, Sungsu; Kim, Yujong; Lee, Byeong-No; Lee, Byung Cheol; Cha, Hyungki; Ha, Jang Ho; Park, Hyung Dal; Lee, Seung Hyun; Kim, Hui Su; Buaphad, Pikad

    2016-04-01

    The radiation equipment research division of Korea Atomic Energy Research Institute has developed a Container Inspection System (CIS) using a Radio Frequency (RF) electron linear accelerator for port security. The primary purpose of the CIS is to detect nuclear materials and explosives, as well country-specific prohibited substances, e.g., smuggled. The CIS consists of a 9/6 MeV dualenergy electron linear accelerator for distinguishing between organic and inorganic materials. The accelerator consists of an electron gun, an RF accelerating structure, an RF driver, a modulator, electromagnets, a cooling system, a X-ray generating target, X-ray collimator, a detector, and a container moving system. The RF driver is an important part of the configuration because it is the RF power source: it supplies the RF power to the accelerating structure. A unique aspect of the RF driver is that it generates dual RF power to generate dual energy (9/6 MeV). The advantage of this RF driver is that it can allow the pulse width to vary and can be used to obtain a wide range of energy output, and pulse repetition rates up to 300 Hz. For this reason, 140 W (5 MW - 9 MeV) and 37 W (3.4 MW - 6 MeV) power outputs are available independently. A high power test for 20 minutes demonstrate that stable dual output powers can be generated. Moreover, the dual power can be applied to the accelerator which has stable accelerator operation. In this paper, the design, fabrication and high power test of the RF driver for the RF electron linear accelerator (linac) are presented.

  6. Applying Metaphor in HRD Research and Practice: Innovative Session.

    ERIC Educational Resources Information Center

    Short, Darren C.; Ardichvili, Alexander; Daley, Barbara J.; Kalata, Erica; Kraemer, Theresa J.; Kuchinke, K. Peter; Willis, Verna J.

    A group of human resource development (HRD) practitioners participated in an innovative session on applying metaphor in HRD research and practice. The session objectives were as follows: (1) facilitate a dialogue between those who wrote for and those who read the Advances in Developing Human Resources (ADHR)issue on metaphor in HRD; (2) extend the…

  7. Clinical leadership development in accelerated baccalaureate nursing students: an education innovation.

    PubMed

    Lekan, Deborah A; Corazzini, Kirsten N; Gilliss, Catherine L; Bailey, Donald E

    2011-01-01

    Nursing faculty members are responsible for assuring competence and safety in the preparation of prelicensure students who are preparing to deliver care in diverse settings. The growing complexity of care and the rapid expansion of knowledge have challenged the adequacy of traditional educational approaches. Proposed solutions have encouraged closer integration of classroom and clinical teaching. This article describes an integrated instructional approach to developing clinical leadership competencies in a cohort of accelerated, second-degree, baccalaureate nursing students. Fifty-six students completed an intensive clinical experience in long-term care settings in which they used evidence on improving care for persons with heart failure to practice the principles of delegation and supervision with nursing staff. The pre- and postassessments indicated improvement in heart failure knowledge and increased readiness for delegation and supervision of certified nursing assistants. As one component of the learning experience, the students completed reflection journals. The entries in the students' journals revealed five themes: (a) low leadership self-efficacy, (b) managing the credibility gap, (c) flexibility in communication strategies, (d) RN accountability in delegation and supervision, and (e) knowledge dissemination with diverse nursing staff. Students and faculty judged the learning experience to be successful and supported the experience for future cohorts of students. This report is one example of how innovative learning experiences could be developed to increase the "real-world" aspects of clinical care within a multidisciplinary team context for the entry-level learner. PMID:21767817

  8. Crizotinib: from discovery to accelerated development to front-line treatment.

    PubMed

    Blackhall, F; Cappuzzo, F

    2016-09-01

    Non-small-cell lung cancer (NSCLC) is associated with a poor prognosis and low survival rates, providing a strong rationale for the development of new treatment options. The discovery of ALK gene rearrangements in a subset of NSCLC specimens and the identification and development of the first-in-class ALK inhibitor crizotinib provided a personalised treatment option for patients with advanced ALK-positive NSCLC. Crizotinib demonstrated rapid and durable responses in advanced ALK-positive NSCLC patients in phase I and II studies, leading to accelerated FDA approval. Subsequent evaluation in phase III studies showed that crizotinib improved progression-free survival compared with platinum-based doublet chemotherapy in previously untreated patients and compared with pemetrexed or docetaxel in previously treated patients. Crizotinib was shown to have an acceptable safety profile and also to improve quality of life and symptom scores. Overall, crizotinib has been shown to provide a valuable first- and second-line treatment option and is now the first-line standard of care for patients with advanced ALK-positive NSCLC. PMID:27573754

  9. MafB deficiency accelerates the development of obesity in mice.

    PubMed

    Tran, Mai Thi Nhu; Hamada, Michito; Nakamura, Megumi; Jeon, Hyojung; Kamei, Risa; Tsunakawa, Yuki; Kulathunga, Kaushalya; Lin, Yuan-Yu; Fujisawa, Kumiko; Kudo, Takashi; Takahashi, Satoru

    2016-06-01

    MafB, a transcription factor expressed selectively in macrophages, has important roles in some macrophage-related diseases, especially in atherosclerosis. In this study, we investigated the mechanism by which hematopoietic-specific MafB deficiency induces the development of obesity. Wild-type and hematopoietic cell-specific Mafb-deficient mice were fed a high-fat diet for 10 weeks. The Mafb-deficient mice exhibited higher body weights and faster rates of body weight increase than control mice. The Mafb-deficient mice also had a higher percentage of body fat than the wild-type mice, due to increased adipocyte size and serum cholesterol levels. Reverse transcription-PCR analysis showed a reduction in apoptosis inhibitor of macrophage (AIM) in Mafb-deficient adipose tissue. AIM is known as an inhibitor of lipogenesis in adipocytes and is expressed in adipose tissue macrophages. Collectively, our data suggest that Mafb deficiency in hematopoietic cells accelerates the development of obesity. PMID:27419056

  10. Development of a subway operation incident delay model using accelerated failure time approaches.

    PubMed

    Weng, Jinxian; Zheng, Yang; Yan, Xuedong; Meng, Qiang

    2014-12-01

    This study aims to develop a subway operational incident delay model using the parametric accelerated time failure (AFT) approach. Six parametric AFT models including the log-logistic, lognormal and Weibull models, with fixed and random parameters are built based on the Hong Kong subway operation incident data from 2005 to 2012, respectively. In addition, the Weibull model with gamma heterogeneity is also considered to compare the model performance. The goodness-of-fit test results show that the log-logistic AFT model with random parameters is most suitable for estimating the subway incident delay. First, the results show that a longer subway operation incident delay is highly correlated with the following factors: power cable failure, signal cable failure, turnout communication disruption and crashes involving a casualty. Vehicle failure makes the least impact on the increment of subway operation incident delay. According to these results, several possible measures, such as the use of short-distance and wireless communication technology (e.g., Wifi and Zigbee) are suggested to shorten the delay caused by subway operation incidents. Finally, the temporal transferability test results show that the developed log-logistic AFT model with random parameters is stable over time. PMID:25171521

  11. High Power Proton Accelerator Development at KAERI and its Vacuum System

    NASA Astrophysics Data System (ADS)

    Choi, Byung-Ho; Park, Mi Young; Kim, Kui Young; Kim, Kye Ryung; Kim, Jun Yeon; Cho, Yong-Sub

    The Proton Engineering Frontier Project (PEFP), approved and launched by the Korean government in July 2002, includes a 100 MeV proton linear accelerator (linac) development and programs for its utilization and application. The main goals in the first phase of the project, spanning from 2002 to 2005, were the design of a 100 MeV proton linac and the development of a 20 MeV linac consisting of a 50 keV proton injector, a 3 MeV radio frequency quadrupole (RFQ), and a 20 MeV drift tube linac (DTL). The 50 keV injector and 3 MeV RFQ have been installed and tested, and the 20 MeV DTL is being assembled, tuned and under a beam test. At the same time, the utilization programs using the proton beam have been planned, and some are now under way. The vacuum system of the 20 MeV proton linac and its related issues, especially in operation with a high duty, are discussed in detail.

  12. Assessing Client Progress Session by Session in the Treatment of Social Anxiety Disorder: The Social Anxiety Session Change Index

    ERIC Educational Resources Information Center

    Hayes, Sarah A.; Miller, Nathan A.; Hope, Debra A.; Heimberg, Richard G.; Juster, Harlan R.

    2008-01-01

    Frequent assessment during therapy can improve treatments and provide accountability. However, clinicians often do not monitor progress because of the time it takes to administer and score assessments. In response, the Social Anxiety Session Change Index (SASCI) was developed. The SASCI is a short, easily administered rating of subjective…

  13. Acceleration modules in linear induction accelerators

    NASA Astrophysics Data System (ADS)

    Wang, Shao-Heng; Deng, Jian-Jun

    2014-05-01

    The Linear Induction Accelerator (LIA) is a unique type of accelerator that is capable of accelerating kilo-Ampere charged particle current to tens of MeV energy. The present development of LIA in MHz bursting mode and the successful application into a synchrotron have broadened LIA's usage scope. Although the transformer model is widely used to explain the acceleration mechanism of LIAs, it is not appropriate to consider the induction electric field as the field which accelerates charged particles for many modern LIAs. We have examined the transition of the magnetic cores' functions during the LIA acceleration modules' evolution, distinguished transformer type and transmission line type LIA acceleration modules, and re-considered several related issues based on transmission line type LIA acceleration module. This clarified understanding should help in the further development and design of LIA acceleration modules.

  14. 96th LHCC meeting Agenda OPEN Session and CLOSED Session

    SciTech Connect

    2010-04-07

    OPEN Session on Wednesday, 19 November 2008 at 9h00-11h00 in Main Auditorium, Live webcast. Followed by CLOSED Session , 6th floor Conference room and continued on Thursday, 20 November 2008 9h00-13h00

  15. 96th LHCC meeting Agenda OPEN Session and CLOSED Session

    ScienceCinema

    None

    2011-10-06

    OPEN Session on Wednesday, 19 November 2008 at 9h00-11h00 in Main Auditorium, Live webcast. Followed by CLOSED Session , 6th floor Conference room and continued on Thursday, 20 November 2008 9h00-13h00

  16. Development of an Accelerated Test Design for Predicting the Service Life of the Solar Array at Mead, Nebraska

    NASA Technical Reports Server (NTRS)

    Gaines, G. B.; Thomas, R. E.; Noel, G. T.; Shilliday, T. S.; Wood, V. E.; Carmichael, D. C.

    1979-01-01

    An accelerated life test is described which was developed to predict the life of the 25 kW photovoltaic array installed near Mead, Nebraska. A quantitative model for accelerating testing using multiple environmental stresses was used to develop the test design. The model accounts for the effects of thermal stress by a relation of the Arrhenius form. This relation was then corrected for the effects of nonthermal environmental stresses, such as relative humidity, atmospheric pollutants, and ultraviolet radiation. The correction factors for the nonthermal stresses included temperature-dependent exponents to account for the effects of interactions between thermal and nonthermal stresses on the rate of degradation of power output. The test conditions, measurements, and data analyses for the accelerated tests are presented. Constant-temperature, cyclic-temperature, and UV types of tests are specified, incorporating selected levels of relative humidity and chemical contamination and an imposed forward-bias current and static electric field.

  17. The MIT HEDP Accelerator Facility for education and advanced diagnostics development for OMEGA, Z and the NIF

    NASA Astrophysics Data System (ADS)

    Petrasso, R.; Gatu Johnson, M.; Armstrong, E.; Han, H. W.; Kabadi, N.; Lahmann, B.; Orozco, D.; Rojas Herrera, J.; Sio, H.; Sutcliffe, G.; Frenje, J.; Li, C. K.; Séguin, F. H.; Leeper, R.; Ruiz, C. L.; Sangster, T. C.

    2015-11-01

    The MIT HEDP Accelerator Facility utilizes a 135-keV linear electrostatic ion accelerator, a D-T neutron source and two x-ray sources for development and characterization of nuclear diagnostics for OMEGA, Z, and the NIF. The ion accelerator generates D-D and D-3He fusion products through acceleration of D ions onto a 3He-doped Erbium-Deuteride target. Fusion reaction rates around 106 s-1 are routinely achieved, and fluence and energy of the fusion products have been accurately characterized. The D-T neutron source generates up to 6 × 108 neutrons/s. The two x-ray generators produce spectra with peak energies of 35 keV and 225 keV and maximum dose rates of 0.5 Gy/min and 12 Gy/min, respectively. Diagnostics developed and calibrated at this facility include CR-39 based charged-particle spectrometers, neutron detectors, and the particle Time-Of-Flight (pTOF) and Magnetic PTOF CVD-diamond-based bang time detectors. The accelerator is also a vital tool in the education of graduate and undergraduate students at MIT. This work was supported in part by SNL, DOE, LLE and LLNL.

  18. DEVELOPMENT OF WATER JET PLASMA MIRROR FOR STAGING OF LASER PLASMA ACCELERATORS

    SciTech Connect

    Panasenko, Dmitriy; Gonsalves, Anthony J.; Leemans, Wim; Nakamura, Kei; Shu, Anthony; Toth, Csaba

    2009-05-04

    Staging Laser Plasma Accelerators (LPAs) is necessary in order to reach beam energies of 100 GeV and above. This requires incoupling of additional laser beams into accelerating stages. In order to maintain the high average accelerating gradient of a staged LPA, it is imperative to minimize the distance that is needed for laser incoupling. A plasma mirror is proposed as the final coupling optic reducing the coupling distance from tens of meters, using a conventional optic, to as small as a few cm. Both a planar water jet and a nitrocellulose foil are used as reflecting surfacesand characterized. A maximum reflectivity of 70percent was obtained using both surfaces.

  19. Posters. [Poster Session at AHRD Conference, 2001].

    ERIC Educational Resources Information Center

    2001

    The first of the papers in this poster session, "Developing the Employment Brand: Targeting MBA Campus Hires" (Diane M. Bergeron), posits that employment branding benefits both individuals and organizations. It functions as a campus recruiting tool in a competitive labor market and communicates the organization's values and work environment to…

  20. OJJDP Family Listening Sessions. Executive Summary

    ERIC Educational Resources Information Center

    Office of Juvenile Justice and Delinquency Prevention, 2013

    2013-01-01

    From March through July 2011, the Office of Juvenile Justice and Delinquency Prevention (OJJDP), in collaboration with the Campaign for Youth Justice and the Education Development Center, convened four listening sessions with families and youth who had direct experiences with the juvenile justice system at the local and state levels. The…

  1. Losartan increases bone mass and accelerates chondrocyte hypertrophy in developing skeleton.

    PubMed

    Chen, Shan; Grover, Monica; Sibai, Tarek; Black, Jennifer; Rianon, Nahid; Rajagopal, Abbhirami; Munivez, Elda; Bertin, Terry; Dawson, Brian; Chen, Yuqing; Jiang, Ming-Ming; Lee, Brendan; Yang, Tao; Bae, Yangjin

    2015-05-01

    Angiotensin receptor blockers (ARBs) are a group of anti-hypertensive drugs that are widely used to treat pediatric hypertension. Recent application of ARBs to treat diseases such as Marfan syndrome or Alport syndrome has shown positive outcomes in animal and human studies, suggesting a broader therapeutic potential for this class of drugs. Multiple studies have reported a benefit of ARBs on adult bone homeostasis; however, its effect on the growing skeleton in children is unknown. We investigated the effect of Losartan, an ARB, in regulating bone mass and cartilage during development in mice. Wild type mice were treated with Losartan from birth until 6 weeks of age, after which bones were collected for microCT and histomorphometric analyses. Losartan increased trabecular bone volume vs. tissue volume (a 98% increase) and cortical thickness (a 9% increase) in 6-weeks old wild type mice. The bone changes were attributed to decreased osteoclastogenesis as demonstrated by reduced osteoclast number per bone surface in vivo and suppressed osteoclast differentiation in vitro. At the molecular level, Angiotensin II-induced ERK1/2 phosphorylation in RAW cells was attenuated by Losartan. Similarly, RANKL-induced ERK1/2 phosphorylation was suppressed by Losartan, suggesting a convergence of RANKL and angiotensin signaling at the level of ERK1/2 regulation. To assess the effect of Losartan on cartilage development, we examined the cartilage phenotype of wild type mice treated with Losartan in utero from conception to 1 day of age. Growth plates of these mice showed an elongated hypertrophic chondrocyte zone and increased Col10a1 expression level, with minimal changes in chondrocyte proliferation. Altogether, inhibition of the angiotensin pathway by Losartan increases bone mass and accelerates chondrocyte hypertrophy in growth plate during skeletal development. PMID:25779879

  2. Losartan increases bone mass and accelerates chondrocyte hypertrophy in developing skeleton

    PubMed Central

    Rianon, Nahid; Rajagopal, Abbhirami; Munivez, Elda; Bertin, Terry; Dawson, Brian; Chen, Yuqing; Jiang, Ming-Ming; Lee, Brendan; Yang, Tao; Bae, Yangjin

    2015-01-01

    Angiotensin receptor blockers (ARBs) are a group of anti-hypertensive drugs that are widely used to treat pediatric hypertension. Recent application of ARBs to treat diseases such as Marfan syndrome or Alport syndrome has shown positive outcomes in animal and human studies, suggesting a broader therapeutic potential for this class of drugs. Multiple studies have reported a benefit of ARBs on adult bone homeostasis; however, its effect on the growing skeleton in children is unknown. We investigated the effect of Losartan, an ARB, in regulating bone mass and cartilage during development in mice. Wild type mice were treated with Losartan from birth until 6 weeks of age, after which bones were collected for microCT and histomorphometric analyses. Losartan increased trabecular bone volume vs. tissue volume (a 98% increase) and cortical thickness (a 9% increase) in 6-weeks old wild type mice. The bone changes were attributed to decreased osteoclastogenesis as demonstrated by reduced osteoclast number per bone surface in vivo and suppressed osteoclast differentiation in vitro. At the molecular level, Angiotensin II-induced ERK1/2 phosphorylation in RAW cells was attenuated by Losartan. Similarly, RANKL-induced ERK1/2 phosphorylation was suppressed by Losartan, suggesting a convergence of RANKL and angiotensin signaling at the level of ERK1/2 regulation. To assess the effect of Losartan on cartilage development, we examined the cartilage phenotype of wild type mice treated with Losartan in utero from conception to 1 day of age. Growth plates of these mice showed an elongated hypertrophic chondrocyte zone and increased Col10a1 expression level, with minimal changes in chondrocyte proliferation. Altogether, inhibition of the angiotensin pathway by Losartan increases bone mass and accelerates chondrocyte hypertrophy in growth plate during skeletal development. PMID:25779879

  3. Session management for web-based healthcare applications.

    PubMed Central

    Wei, L.; Sengupta, S.

    1999-01-01

    In health care systems, users may access multiple applications during one session of interaction with the system. However, users must sign on to each application individually, and it is difficult to maintain a common context among these applications. We are developing a session management system for web-based applications using LDAP directory service, which will allow single sign-on to multiple web-based applications, and maintain a common context among those applications for the user. This paper discusses the motivations for building this system, the system architecture, and the challenges of our approach, such as the session objects management for the user, and session security. PMID:10566511

  4. An Accelerated Analytical Process for the Development of STR Profiles for Casework Samples.

    PubMed

    Laurin, Nancy; Frégeau, Chantal J

    2015-07-01

    Significant efforts are being devoted to the development of methods enabling rapid generation of short tandem repeat (STR) profiles in order to reduce turnaround times for the delivery of human identification results from biological evidence. Some of the proposed solutions are still costly and low throughput. This study describes the optimization of an analytical process enabling the generation of complete STR profiles (single-source or mixed profiles) for human identification in approximately 5 h. This accelerated process uses currently available reagents and standard laboratory equipment. It includes a 30-min lysis step, a 27-min DNA extraction using the Promega Maxwell(®) 16 System, DNA quantification in <1 h using the Qiagen Investigator(®) Quantiplex HYres kit, fast amplification (<26 min) of the loci included in AmpFℓSTR(®) Identifiler(®), and analysis of the profiles on the 3500-series Genetic Analyzer. This combination of fast individual steps produces high-quality profiling results and offers a cost-effective alternative approach to rapid DNA analysis. PMID:25782346

  5. Development of the CRISP Package for Spallation Studies and Accelerator-Driven Systems

    SciTech Connect

    Anefalos, S.; Deppman, A.; Silva, Gilson da; Maiorino, J.R.; Santos, A. dos; Garcia, F.

    2005-09-15

    Power generation from nuclear reactors provides an almost inexhaustive power source due to the huge quantities of nuclear fuel existent in our planet, which guarantees its utilization for thousands of years. Interest has been shifted to the so-called hybrid reactors [accelerator-driven systems (ADS)] as an alternative technology for power generation and transmutation, thus requiring precise knowledge about nuclear structure and nuclear reaction characteristics. Research groups from Instituto de Fisica, Universidade de Sao Paulo and Brazilian Center for Research in Physics made a joint effort to develop a computer program, CRISP, to calculate the intranuclear cascade proprieties and the nuclear evaporation process, present in all nuclear reactions with energies above a few tens of mega-electron-volts, using Monte Carlo techniques. Some reaction channels were included in these programs, resulting in a more realistic representation of the processes involved, aiming at reactor physics studies and academic studies about hadron and meson properties in nuclear matter. Some results obtained with this code and a comparison with experimental data are presented. Although all these results are preliminary, they are very consistent with the available experimental data. Since the applicability of the CRISP package has a wide range of options, especially in ADS, some results describing the effectiveness of the code were achieved.

  6. Development of TiN Coating System for Long Beam Ducts of Accelerators

    NASA Astrophysics Data System (ADS)

    Shibata, Kyo; Hisamatsu, Hiromi; Kanazawa, Ken-Ichi; Suetsugu, Yusuke; Shirai, Mitsuru

    A Titanium Nitride (TiN) coating system for long beam ducts of accelerators was developed to reduce the secondary electron yield (SEY) from the inner surface and to mitigate the electron cloud effect. Coating was carried out by DC magnetron sputtering of pure titanium in argon (2.0 Pa) and nitrogen (0.5 Pa) atmospheres. A copper beam duct with a maximum length of 3.6 m was set vertically, and a titanium rod as a cathode was suspended from the top along the central axis of the duct. A movable solenoid coil with a length of 0.8 m externally supplied a magnetic field of 16 mT to accommodate the long duct. By moving the solenoid coil at specified time intervals, the TiN film was uniformly coated on the inner surface. The thickness of the coating was 200 nm, and the temperature of the ducts during the coating was 130°C. Several coated ducts were installed into the KEKB positron ring during the summer shutdown in 2007. In the subsequent beam operation, the reduction of electrons in the coated duct was confirmed.

  7. New developments of 11C post-accelerated beams for hadron therapy and imaging

    NASA Astrophysics Data System (ADS)

    Augusto, R. S.; Mendonca, T. M.; Wenander, F.; Penescu, L.; Orecchia, R.; Parodi, K.; Ferrari, A.; Stora, T.

    2016-06-01

    Hadron therapy was first proposed in 1946 and is by now widespread throughout the world, as witnessed with the design and construction of the CNAO, HIT, PROSCAN and MedAustron treatment centres, among others. The clinical interest in hadron therapy lies in the fact that it delivers precision treatment of tumours, exploiting the characteristic shape (the Bragg peak) of the energy deposition in the tissues for charged hadrons. In particular, carbon ion therapy is found to be biologically more effective, with respect to protons, on certain types of tumours. Following an approach tested at NIRS in Japan [1], carbon ion therapy treatments based on 12C could be combined or fully replaced with 11C PET radioactive ions post-accelerated to the same energy. This approach allows providing a beam for treatment and, at the same time, to collect information on the 3D distributions of the implanted ions by PET imaging. The production of 11C ion beams can be performed using two methods. A first one is based on the production using compact PET cyclotrons with 10-20 MeV protons via 14N(p,α)11C reactions following an approach developed at the Lawrence Berkeley National Laboratory [2]. A second route exploits spallation reactions 19F(p,X)11C and 23Na(p,X)11C on a molten fluoride salt target using the ISOL (isotope separation on-line) technique [3]. This approach can be seriously envisaged at CERN-ISOLDE following recent progresses made on 11C+ production [4] and proven post-acceleration of pure 10C3/6+ beams in the REX-ISOLDE linac [5]. Part of the required components is operational in radioactive ion beam facilities or commercial medical PET cyclotrons. The driver could be a 70 MeV, 1.2 mA proton commercial cyclotron, which would lead to 8.1 × 10711C6+ per spill. This intensity is appropriate using 11C ions alone for both imaging and treatment. Here we report on the ongoing feasibility studies of such approach, using the Monte Carlo particle transport code FLUKA [6,7] to simulate

  8. Developments in accelerators and instrumentation relevant to imaging with charged particles and positron emitters

    SciTech Connect

    Alonso, J.R.

    1980-11-01

    In past years particle accelerators have become increasingly important tools for the advancement of medical science. From the pace of advancing technology and current directions in medical research, it is clear that this relationship between accelerators and medicine will only grow stronger in future years. In view of this importance, this relationship is investigated in some detail, with an eye not so much towards the medical uses of the beams produced, but more towards the technology associated with these accelerators and the criteria which make for successful incorporation of these machines into the clinical environment. In order to lay the necessary groundwork, the different kinds of accelerators found in medical use today are reviewed briefly discussing salient points of each.

  9. Land subsidence session

    NASA Astrophysics Data System (ADS)

    Holzer, Thomas L.

    A session on land subsidence caused by withdrawal of groundwater was held December 10, 1985, in San Francisco, Calif., at the AGU Fall Meeting. The symposium was organized by William E. Strange (National Geodetic Survey, Rockville, Md.) and Thomas L. Holzer (U.S. Geological Survey (USGS), Menlo Park, Calif.) and was cosponsored by the AGU Geodesy and Hydrology sections. Nine papers were presented on topics that ranged from evaluations of the suitability of the new satellite-based Global Positioning System (GPS) to theoretical analyses of land subsidence.T. N. Narasimhan (Lawrence Berkeley Laboratories, Berkeley, Calif.) introduced the general subject of subsidence with a review of relevant physical processes. Compaction, although conceptually simple, involves several complexities, including plastic deformation and translation of deep-seated deformation through the overburden. Sashi Mathur (Tarleton State University, Stephenville, Tex.), in a paper coauthored with M. Yavuz Corapcioglu (City College of New York, New York), analyzed deformation in the unsaturated zone above a falling water table. Their theoretical formulation was able to reproduce results from laboratory studies of sand columns.

  10. Muscle contributions to centre of mass acceleration during turning gait in typically developing children: A simulation study.

    PubMed

    Dixon, Philippe C; Jansen, Karen; Jonkers, Ilse; Stebbins, Julie; Theologis, Tim; Zavatsky, Amy B

    2015-12-16

    Turning while walking requires substantial joint kinematic and kinetic adaptations compared to straight walking in order to redirect the body centre of mass (COM) towards the new walking direction. The role of muscles and external forces in controlling and redirecting the COM during turning remains unclear. The aim of this study was to compare the contributors to COM medio-lateral acceleration during 90° pre-planned turns about the inside limb (spin) and straight walking in typically developing children. Simulations of straight walking and turning gait based on experimental motion data were implemented in OpenSim. The contributors to COM global medio-lateral acceleration during the approach (outside limb) and turn (inside limb) stance phase were quantified via an induced acceleration analysis. Changes in medio-lateral COM acceleration occurred during both turning phases, compared to straight walking (p<0.001). During the approach, outside limb plantarflexors (soleus and medial gastrocnemius) contribution to lateral (away from the turn side) COM acceleration was reduced (p<0.001), whereas during the turn, inside limb plantarflexors (soleus and gastrocnemii) contribution to lateral acceleration (towards the turn side) increased (p≤0.013) and abductor (gluteus medius and minimus) contribution medially decreased (p<0.001), compared to straight walking, together helping accelerate the COM towards the new walking direction. Knowledge of the changes in muscle contributions required to modulate the COM position during turning improves our understanding of the control mechanisms of gait and may be used clinically to guide the management of gait disorders in populations with restricted gait ability. PMID:26555714

  11. Development and low power test of the parallel coupled accelerating structure

    NASA Astrophysics Data System (ADS)

    Andrianov, A. V.; Barnyakov, A. M.; Levichev, A. E.; Maltseva, M. V.; Nikiforov, D. A.; Samoylov, S. L.

    2016-06-01

    The parallel coupled accelerating structure with a frequency of 2856 MHz is described. The cavities and the power propagation efficiencies are calculated. The results of the structure tuning are described. Analysis of the measurements and comparison with calculated data are provided. On the base of the measured parameters of the parallel coupled accelerating structure the beam energy under different meanings of the current is predicted.

  12. Report of the Subpanel on Accelerator Research and Development of the High Energy Physics Advisory Panel

    SciTech Connect

    Not Available

    1980-06-01

    Accelerator R and D in the US High Energy Physics (HEP) program is reviewed. As a result of this study, some shift in priority, particularly as regards long-range accelerator R and D, is suggested to best serve the future needs of the US HEP program. Some specific new directions for the US R and D effort are set forth. 18 figures, 5 tables. (RWR)

  13. Development and Use of Mark Sense Record Cards for Recording Medical Data on Pilots Subjected to Acceleration Stress

    NASA Technical Reports Server (NTRS)

    Smedal, Harald A.; Havill, C. Dewey

    1962-01-01

    A TIME-HONORED system of recording medical histories and the data obtained on physical and laboratory examination has been that of writing the information on record sheets that go into a folder for each patient. In order to have information which would be more readily retrieved, 'a program was initiated in 1952 by the U. S. Naval School of Aviation Medicine in connection with their "Care of the Flyer" study to place this information on machine record cards. In 1958, a machine record card method was developed for recording medical data in connection with the astronaut selection program. Machine record cards were also developed by the Aero Medical Laboratory, Wright-Patterson AFB, Ohio, and the Aviation Medical Acceleration Laboratory, Naval Air Development Center, Johnsville, Pennsylvania, for use in connection with a variety of tests including acceleration stress.1 Therefore, a variety of systems resulted in which data of a medical nature could easily be recalled. During the NASA, Ames Research Center centrifuge studies/'S the pilot subjects were interviewed after each centrifuge run, or series of runs, and subjective information was recorded in a log book by the usual history taking methods referred to above. After the methods Were reviewed, it' was recognized that a card system would be very useful in recording data from our pilots after they had been exposed to acceleration stress. Since the acceleration stress cards already developed did not meet our requirements, it was decided a different card was needed.

  14. Development of design technique for vacuum insulation in large size multi-aperture multi-grid accelerator for nuclear fusion.

    PubMed

    Kojima, A; Hanada, M; Tobari, H; Nishikiori, R; Hiratsuka, J; Kashiwagi, M; Umeda, N; Yoshida, M; Ichikawa, M; Watanabe, K; Yamano, Y; Grisham, L R

    2016-02-01

    Design techniques for the vacuum insulation have been developed in order to realize a reliable voltage holding capability of multi-aperture multi-grid (MAMuG) accelerators for fusion application. In this method, the nested multi-stage configuration of the MAMuG accelerator can be uniquely designed to satisfy the target voltage within given boundary conditions. The evaluation of the voltage holding capabilities of each acceleration stages was based on the previous experimental results about the area effect and the multi-aperture effect. Since the multi-grid effect was found to be the extension of the area effect by the total facing area this time, the total voltage holding capability of the multi-stage can be estimated from that per single stage by assuming the stage with the highest electric field, the total facing area, and the total apertures. By applying these consideration, the analysis on the 3-stage MAMuG accelerator for JT-60SA agreed well with the past gap-scan experiments with an accuracy of less than 10% variation, which demonstrated the high reliability to design MAMuG accelerators and also multi-stage high voltage bushings. PMID:26932032

  15. Development of design technique for vacuum insulation in large size multi-aperture multi-grid accelerator for nuclear fusion

    NASA Astrophysics Data System (ADS)

    Kojima, A.; Hanada, M.; Tobari, H.; Nishikiori, R.; Hiratsuka, J.; Kashiwagi, M.; Umeda, N.; Yoshida, M.; Ichikawa, M.; Watanabe, K.; Yamano, Y.; Grisham, L. R.

    2016-02-01

    Design techniques for the vacuum insulation have been developed in order to realize a reliable voltage holding capability of multi-aperture multi-grid (MAMuG) accelerators for fusion application. In this method, the nested multi-stage configuration of the MAMuG accelerator can be uniquely designed to satisfy the target voltage within given boundary conditions. The evaluation of the voltage holding capabilities of each acceleration stages was based on the previous experimental results about the area effect and the multi-aperture effect. Since the multi-grid effect was found to be the extension of the area effect by the total facing area this time, the total voltage holding capability of the multi-stage can be estimated from that per single stage by assuming the stage with the highest electric field, the total facing area, and the total apertures. By applying these consideration, the analysis on the 3-stage MAMuG accelerator for JT-60SA agreed well with the past gap-scan experiments with an accuracy of less than 10% variation, which demonstrated the high reliability to design MAMuG accelerators and also multi-stage high voltage bushings.

  16. Recent developments in the application of rf superconductivity to high-brightness and high-gradient ion beam accelerators

    SciTech Connect

    Delayen, J.R.; Bohn, C.L.; Kennedy, W.L.; Nichols, G.L.; Roche, C.T.; Sagalovsky, L.

    1991-12-31

    A development program is underway to apply rf superconductivity to the design of continuous-wave (cw) linear accelerators for high- brightness ion beams. Since the last workshop, considerable progress has been made both experimentally and theoretically toward this application. Recent tests of niobium resonators for ion acceleration have yielded average accelerating gradients as high as 18 MV/m. In an experiment with a radio-frequency quadrupole geometry, niobium was found to sustain cw peak surface electric fields as high as 128 MV/m over large (10 cm{sup 2}) surface areas. Theoretical studies of beam impingement and cumulative beam breakup have also yielded encouraging results. Consequently, a section of superconducting resonators and focusing elements has been designed for tests with high-current deuteron beams. In addition, considerable data pertaining to the rf properties of high-{Tc} superconductors has been collected at rf-field amplitudes and frequencies of interest in connection with accelerator operation. This paper summarizes the recent progress and identifies current and future work in the areas of accelerator technology and superconducting materials which will build upon it.

  17. Recent developments in the application of rf superconductivity to high-brightness and high-gradient ion beam accelerators

    SciTech Connect

    Delayen, J.R.; Bohn, C.L.; Kennedy, W.L.; Nichols, G.L.; Roche, C.T.; Sagalovsky, L.

    1991-01-01

    A development program is underway to apply rf superconductivity to the design of continuous-wave (cw) linear accelerators for high- brightness ion beams. Since the last workshop, considerable progress has been made both experimentally and theoretically toward this application. Recent tests of niobium resonators for ion acceleration have yielded average accelerating gradients as high as 18 MV/m. In an experiment with a radio-frequency quadrupole geometry, niobium was found to sustain cw peak surface electric fields as high as 128 MV/m over large (10 cm{sup 2}) surface areas. Theoretical studies of beam impingement and cumulative beam breakup have also yielded encouraging results. Consequently, a section of superconducting resonators and focusing elements has been designed for tests with high-current deuteron beams. In addition, considerable data pertaining to the rf properties of high-{Tc} superconductors has been collected at rf-field amplitudes and frequencies of interest in connection with accelerator operation. This paper summarizes the recent progress and identifies current and future work in the areas of accelerator technology and superconducting materials which will build upon it.

  18. Acceleration Studies

    NASA Technical Reports Server (NTRS)

    Rogers, Melissa J. B.

    1993-01-01

    Work to support the NASA MSFC Acceleration Characterization and Analysis Project (ACAP) was performed. Four tasks (analysis development, analysis research, analysis documentation, and acceleration analysis) were addressed by parallel projects. Work concentrated on preparation for and implementation of near real-time SAMS data analysis during the USMP-1 mission. User support documents and case specific software documentation and tutorials were developed. Information and results were presented to microgravity users. ACAP computer facilities need to be fully implemented and networked, data resources must be cataloged and accessible, future microgravity missions must be coordinated, and continued Orbiter characterization is necessary.

  19. Development of an ADME and drug-drug interactions knowledge database for the acceleration of drug discovery and development.

    PubMed

    Petitet, François; Barberan, Olivier; Dubus, Elodie; Ijjaali, Ismail; Donlan, Mary; Ollivier, Sophie; Michel, André

    2006-12-01

    It is widely recognised that predicting or determining the absorption, distribution, metabolism and excretion (ADME) properties of a compound as early as possible in the drug discovery process helps to prevent costly late-stage failures. Although in recent years high-throughput in vitro absorption distribution metabolism excretion toxicity (ADMET) screens have been implemented, more efficient in silico filters are still highly needed to predict and model the most relevant metabolic and pharmacokinetic end points, and thereby accelerate drug discovery and development. The usefulness of the data generated and published for the chemist, biologist or project manager who ultimately wants to understand and optimise the ADME properties of lead compounds cannot be argued with. Collecting and comparing data is an overwhelming task for the time-pressed scientist. Aureus Pharma provides a uniquely specialised solution for knowledge generation in drug discovery. AurSCOPE(®) ADME/DDI (drug-drug interaction) is a fully annotated, structured knowledge database containing all the pertinent biological and chemical information on the metabolic properties of drugs. This Aureus knowledge database has proven to be highly useful in designing predictive models and identifying potential drug-drug interactions. PMID:23495997

  20. Speed Posters: An Alternative to Traditional Poster and Podium Sessions.

    PubMed

    Wagnes, Lisa D

    2016-08-01

    Speed posters were used as an alternative concurrent session option during a national nursing education conference. The session format was received positively by both participants and presenters, and, as a result, recommendations for use were developed by the conference planners. J Contin Educ Nurs. 2016;47(8):344-346. PMID:27467306

  1. Stem Cell–Derived Bioactive Materials Accelerate Development of Porcine In Vitro–Fertilized Embryos

    PubMed Central

    Lee, Seung-Eun; Moon, Jeremiah Ji-Man; Kim, Eun-Young

    2015-01-01

    Abstract Stem cells show the capability to proliferate in an undifferentiated state with long-term self-renewal, which gives the cells advantages for use as bioactive material (BM) for embryo culture in vitro. The objective of this experiment was to investigate the effect of two BMs—human adipose tissue–derived mesenchymal stem cell BM (hAT-MSC-BM) and human embryonic stem cell–derived BM (hESC-BM)—on porcine embryo development compared to commonly used bovine serum albumin (BSA) or serum treatment groups. In vitro–fertilized (IVF) embryos were cultured in PZM-5 with 4 mg/mL BSA until day 4 and equally divided into four groups. Starting from day 4 (until day 6), each group was treated with the following protein additives: 4 mg/mL BSA (control), 10% fetal bovine serum (FBS), 10% hAT-MSC-BM, or 10% hESC-BM. Our results show FBS- and two other BM-treated groups showed significant increases in blastocyst formation rate, hatching rate, and total cell number compared with the control group (p<0.05). The hAT-MSC-BM and hESC-BM treatment groups presented better-quality embryo development, especially from the middle expanding stage to hatching. In particular, the hAT-MSC-BM–treated group showed the highest developmental potential of all groups and formed the most expanding-stage blastocysts. The relative expression of reprogramming-related transcription factor (POU5F1, SOX2, DPPA5, and CDH1), antioxidant (PRDX5), and apoptosis (BCL2L1 and BIRC5) genes also increased in two types of BMs compared to the control. In addition, we investigated the protein synthesis of the tight junction– and gap junction–related genes, connexin 43 and zonula occludens-1 (ZO-1); these increased more than in the control. These results demonstrate that stem cell–derived BMs accelerate porcine preimplantation embryo development and that the BMs would be helpful in the development of preimplantation embryos. PMID:26053518

  2. Interesting experimental results in Japan Proton Accelerator Research Complex H- ion-source development (invited).

    PubMed

    Ueno, A; Oguri, H; Ikegami, K; Namekawa, Y; Ohkoshi, K

    2010-02-01

    The following interesting experimental results observed in Japan Proton Accelerator Research Complex (J-PARC) H(-) ion-source developments are reviewed. It was proven that almost all of H(-) ions were produced with surface reactions in cesium (Cs)-free J-PARC H(-) ion-sources. The world's most intense class H(-) ion current of 38 mA in Cs-free ion sources for a high-energy linac was attained by an optimal shape and high temperature of the plasma electrode (PE), usage of a lanthanum hexaboride (LaB(6)) filament, and a newly devised high-power constant-current pulsed-arc power supply indispensable for it. It was also proven that the H(-) ion current could be increased to more than 40 mA by optimizing LaB(6)-filament shape. The surface elemental analysis of the PE after operation with a LaB(6)-filament showed that it was coated by boron (B) 95.5%, lanthanum (La) 2.5%, and oxygen (O) 1.9%. The H(-) ion current decreased by about 20% when a tungsten (W) filament was used instead of a LaB(6)-filament. The H(-) ion current could not be increased by seeding cesium (Cs) if the LaB(6)-filament was used. On the other hand, it was increased to more than 70 mA with much lower arc current of 150 A if Cs was seeded when a W-filament was used. PMID:20192389

  3. Phosphodiesterase-5 inhibitors oppose hyperoxic vasoconstriction and accelerate seizure development in rats exposed to hyperbaric oxygen.

    PubMed

    Demchenko, Ivan T; Ruehle, Alex; Allen, Barry W; Vann, Richard D; Piantadosi, Claude A

    2009-04-01

    Oxygen is a potent cerebral vasoconstrictor, but excessive exposure to hyperbaric oxygen (HBO(2)) can reverse this vasoconstriction by stimulating brain nitric oxide (NO) production, which increases cerebral blood flow (CBF)-a predictor of O(2) convulsions. We tested the hypothesis that phosphodiesterase (PDE)-5 blockers, specifically sildenafil and tadalafil, increase CBF in HBO(2) and accelerate seizure development. To estimate changes in cerebrovascular responses to hyperoxia, CBF was measured by hydrogen clearance in anesthetized rats, either control animals or those pretreated with one of these blockers, with the NO inhibitor N(omega)-nitro-l-arginine methyl ester (l-NAME), with the NO donor S-nitroso-N-acetylpenicillamine (SNAP), or with a blocker combined with l-NAME. Animals were exposed to 30% O(2) at 1 atm absolute (ATA) ("air") or to 100% O(2) at 4 or 6 ATA. EEG spikes indicated central nervous system CNS O(2) toxicity. The effects of PDE-5 blockade varied as a positive function of ambient Po(2). In air, CBF did not increase significantly, except after pretreatment with SNAP. However, at 6 ATA O(2), mean values for CBF increased and values for seizure latency decreased, both significantly; pretreatment with l-NAME abolished these effects. Conscious rats treated with sildenafil before HBO(2) were also more susceptible to CNS O(2) toxicity, as demonstrated by significantly shortened convulsive latency. Decreases in regional CBF reflect net vasoconstriction in the brain regions studied, since mean arterial pressures remained constant or increased throughout. Thus PDE-5 blockers oppose the protective vasoconstriction that is the initial response to hyperbaric hyperoxia, decreasing the safety of HBO(2) by hastening onset of CNS O(2) toxicity. PMID:19179645

  4. How can accelerated development of bioenergy contribute to the future UK energy mix? Insights from a MARKAL modelling exercise

    PubMed Central

    Clarke, Donna; Jablonski, Sophie; Moran, Brighid; Anandarajah, Gabrial; Taylor, Gail

    2009-01-01

    Background This work explores the potential contribution of bioenergy technologies to 60% and 80% carbon reductions in the UK energy system by 2050, by outlining the potential for accelerated technological development of bioenergy chains. The investigation was based on insights from MARKAL modelling, detailed literature reviews and expert consultations. Due to the number and complexity of bioenergy pathways and technologies in the model, three chains and two underpinning technologies were selected for detailed investigation: (1) lignocellulosic hydrolysis for the production of bioethanol, (2) gasification technologies for heat and power, (3) fast pyrolysis of biomass for bio-oil production, (4) biotechnological advances for second generation bioenergy crops, and (5) the development of agro-machinery for growing and harvesting bioenergy crops. Detailed literature searches and expert consultations (looking inter alia at research and development needs and economic projections) led to the development of an 'accelerated' dataset of modelling parameters for each of the selected bioenergy pathways, which were included in five different scenario runs with UK-MARKAL (MED). The results of the 'accelerated runs' were compared with a low-carbon (LC-Core) scenario, which assesses the cheapest way to decarbonise the energy sector. Results Bioenergy was deployed in larger quantities in the bioenergy accelerated technological development scenario compared with the LC-Core scenario. In the electricity sector, solid biomass was highly utilised for energy crop gasification, displacing some deployment of wind power, and nuclear and marine to a lesser extent. Solid biomass was also deployed for heat in the residential sector from 2040 in much higher quantities in the bioenergy accelerated technological development scenario compared with LC-Core. Although lignocellulosic ethanol increased, overall ethanol decreased in the transport sector in the bioenergy accelerated technological

  5. 77 FR 60373 - Board of Directors Executive Session Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-03

    ...; ] AFRICAN DEVELOPMENT FOUNDATION Board of Directors Executive Session Meeting Meeting: African Development..., October 11, 2012, 5 p.m. to 6:30 p.m. Lloyd O. Pierson, President & CEO, United States African...

  6. Development of a 10 MW, 91 GHz Gyroklystron for W-Band Linear Accelerators

    NASA Astrophysics Data System (ADS)

    Nielson, Jeff; Ives, Lawrence; Lawson, Wes; Arjona, Melany

    1999-11-01

    An international effort is underway to design advanced linear electron-positron colliders with mass energies beyond 1 TeV. High power RF sources are required to drive accelerators operating at frequencies as high as W-Band. Calabazas Creek Research, Inc. is funded by the U.S. Department of Energy to design a 10 MW, second harmonic, gyroklystron at 91 GHz. The program is coordinated with W-Band accelerator research at the Stanford Linear Accelerator Center. The goal is to achieve an electronic efficiency of 45presentation will describe the proposed electron gun, three cavity RF circuit, magnetic circuit, and input and output couplers. Current simulation results will be presented and design tradeoffs will be discussed.

  7. Development of a two-stage light gas gun to accelerate hydrogen pellets to high speeds for plasma fueling applications

    SciTech Connect

    Combs, S.K.; Milora, S.L.; Foust, C.R.; Gouge, M.J.; Fehling, D.T.; Sparks, D.O.

    1988-01-01

    The development of a two-stage light gas gun to accelerate hydrogen isotope pellets to high speeds is under way at Oak Ridge National Laboratory. High velocities (>2 km/s) are desirable for plasma fueling applications, since the faster pellets can penetrate more deeply into large, hot plasmas and deposit atoms of fuel directly in a larger fraction of the plasma volume. In the initial configuration of the two-stage device, a 2.2-l volume (/<=/55-bar) provides the gas to accelerate a 25.4-mm-diam piston in a 1-m-long pump tube; a burst disk or a fast valve initiates the acceleration process in the first stage. As the piston travels the length of the pump tube, the downstream gas (initially at <1 bar) is compressed (to pressures up to 2600 bar) and thus is driven to high temperature (approx.5000 K). This provides the driving force for acceleration of a 4-mm pellet in a 1-m-long gun barrel. In preliminary tests using helium as the driver in both stages, 35-mg plastic pellets have been accelerated to speeds as high as 3.8 km/s. Projectiles composed of hydrogen ice will have a mass in the range from 5 to 20 mg (/rho/ approx. 0.087, 0.20, and 0.32 g/cm/sup 3/ for frozen hydrogen isotopes). However, the use of sabots to encase and protect the cryogenic pellets from the high peak pressures will probably be required to realize speeds of approx.3 km/s or greater. The experimental plan includes acceleration of hydrogen isotopes as soon as the gun geometry and operating parameters are optimized; theoretical models are being used to aid in this process. The hardware is being designed to accommodate repetitive operation, which is the objective of this research and is required for future applications. 25 refs., 6 figs., 1 tab.

  8. High intensity hadron accelerators

    SciTech Connect

    Teng, L.C.

    1989-05-01

    This rapporteur report consists mainly of two parts. Part I is an abridged review of the status of all High Intensity Hadron Accelerator projects in the world in semi-tabulated form for quick reference and comparison. Part II is a brief discussion of the salient features of the different technologies involved. The discussion is based mainly on my personal experiences and opinions, tempered, I hope, by the discussions I participated in in the various parallel sessions of the workshop. In addition, appended at the end is my evaluation and expression of the merits of high intensity hadron accelerators as research facilities for nuclear and particle physics.

  9. CO2 enrichment accelerates successional development of an understory plant community

    SciTech Connect

    Souza, Lara; Belote, R. Travis Travis; Kardol, Paul; Weltzin, Jake; Norby, Richard J

    2010-01-01

    61% in aCO{sub 2} and only 33% in eCO{sub 2} treatments. Our results suggest that rising atmospheric [CO{sub 2}] could accelerate successional development and have longer term impact on forest dynamics.

  10. DEVELOPMENT OF ACCELERATOR DATA REPORTING SYSTEM AND ITS APPLICATION TO TREND ANALYSIS OF BEAM CURRENT DATA

    SciTech Connect

    Padilla, M.J.; Blokland, W.

    2009-01-01

    Detailed ongoing information about the ion beam quality is crucial to the successful operation of the Spallation Neutron Source at Oak Ridge National Laboratory. In order to provide the highest possible neutron production time, ion beam quality is monitored to isolate possible problems or performance-related issues throughout the accelerator and accumulator ring. For example, beam current monitor (BCM) data is used to determine the quality of the beam transport through the accelerator. In this study, a reporting system infrastructure was implemented and used to generate a trend analysis report of the BCM data. The BCM data was analyzed to facilitate the identifi cation of monitor calibration issues, beam trends, beam abnormalities, beam deviations and overall beam quality. A comparison between transformed BCM report data and accelerator log entries shows promising results which represent correlations between the data and changes made within the accelerator. The BCM analysis report is one of many reports within a system that assist in providing overall beam quality information to facilitate successful beam operation. In future reports, additional data manipulation functions and analysis can be implemented and applied. Built-in and user-defi ned analytic functions are available throughout the reporting system and can be reused with new data.

  11. Development of millimeter-wave accelerating structures using precision metal forming technology

    SciTech Connect

    2003-06-03

    High gradients in radio-frequency (RF) driven accelerators require short wavelengths that have the concomitant requirements of small feature size and high tolerances, 1-2 {micro}m for millimeter wavelengths. Precision metal-forming stampling has the promise of meeting those tolerances with high production rates. This STI will evaluate that promise.

  12. Veterans' Accelerated Urban Learning for Teaching (V.A.U.L.T.); Program Development and Projection.

    ERIC Educational Resources Information Center

    Webster Coll., St. Louis, MO.

    The Webster College Veterans' Accelerated Urban Learning for Teaching (VAULT) program, initiated in 1968-69, is designed to train the disadvantaged (primarily Negro veterans who would not normally attend college) to teach in ghetto elementary schools. Its purpose is to serve veterans and to control the following deficiencies in higher education:…

  13. Research and development for electropolishing of Nb for ILC accelerator cavities

    SciTech Connect

    Kelley, Michael J.

    2009-09-21

    The objectives of this project are to 1, Expand the scientific and technological understanding of the effect of post-treatment (electropolish, buffered chemical polish, low-temperature baking) on the surface of niobium; 2, Relate the knowledge to the performance of niobium superconducting radiofrequency accelerator cavities; and, 3, Thereby design and demonstrate an electropolish process that can be applied to complete cavities.

  14. The Evolutionary Dynamics of Education Systems: Exposition on Institutional Development. International Commission on Education for the Twenty-First Century, Second Session (Dakar, Senegal, September 18-22, 1993).

    ERIC Educational Resources Information Center

    Carneiro, Roberto

    This paper analyzes the stages of educational development beginning in the 1950s and 1960s, when mass economies began to emerge, immediately after World War II. This essay covers the last 40 years that have been characterized by rapid change and the most fascinating acceleration in the history of humanity. During those four decades, education…

  15. Accelerator-Based Boron Neutron Capture Therapy and the Development of a Dedicated Tandem-Electrostatic-Quadrupole

    SciTech Connect

    Kreiner, A. J.; Di Paolo, H.; Burlon, A. A.; Valda, A. A.; Debray, M. E.; Somacal, H. R.; Minsky, D. M.; Kesque, J. M.; Giboudot, Y.; Levinas, P.; Fraiman, M.; Romeo, V.

    2007-10-26

    There is a generalized perception that the availability of suitable particle accelerators installed in hospitals, as neutron sources, may be crucial for the advancement of Boron Neutron Capture Therapy (BNCT). Progress on an ongoing project to develop a Tandem-ElectroStatic-Quadrupole (TESQ) accelerator for Accelerator-Based (AB)-BNCT is described here. The project goal is a machine capable of delivering 30 mA of 2.5 MeV protons to be used in conjunction with a neutron production target based on the {sup 7}Li(p,n){sup 7}Be reaction slightly beyond its resonance at 2.25 MeV. A folded tandem, with 1.25 MV terminal voltage, combined with an ESQ chain is being designed and constructed. A 30 mA proton beam of 2.5 MeV are the specifications needed to produce sufficiently intense and clean epithermal neutron beams, based on the {sup 7}Li(p,n){sup 7}Be reaction, to perform BNCT treatment for deep-seated tumors in less than an hour. The first design and construction of an ESQ module is discussed and its electrostatic fields are investigated theoretically and experimentally. Also new beam transport calculations through the accelerator are presented.

  16. Development of an Emergency Locking Unit for a Belt-In-Seat (BIS) System Using a MEMS Acceleration Sensor

    PubMed Central

    Baek, Chang Hyun; Lee, Jeong Wan; Kim, Seock Hyun; Paek, Insu

    2010-01-01

    This paper proposes an emergency locking unit (ELU) for a seat belt retractor which is mounted on the back frame of a vehicle seat. The proposed unit uses a recliner sensor based on a MEMS acceleration sensor and solenoid mechanism. The seat has an upper frame supported to tilt on a lower frame. The retractor in belt in seat (BIS) system is supported by the upper frame. The proposed recliner sensor based on a MEMS acceleration sensor comprises orientation means for maintaining a predetermined orientation of emergency relative to the lower frame independently of the force of gravity when the upper frame tilts on the lower frame. Experimental results show that the developed recliner sensor unit operates effectively with respect to rollover angles. Thus, the developed unit will have a considerable potential to offer a new design concept in BIS system. PMID:22319324

  17. Linear Accelerators

    NASA Astrophysics Data System (ADS)

    Sidorin, Anatoly

    2010-01-01

    In linear accelerators the particles are accelerated by either electrostatic fields or oscillating Radio Frequency (RF) fields. Accordingly the linear accelerators are divided in three large groups: electrostatic, induction and RF accelerators. Overview of the different types of accelerators is given. Stability of longitudinal and transverse motion in the RF linear accelerators is briefly discussed. The methods of beam focusing in linacs are described.

  18. Linear Accelerators

    SciTech Connect

    Sidorin, Anatoly

    2010-01-05

    In linear accelerators the particles are accelerated by either electrostatic fields or oscillating Radio Frequency (RF) fields. Accordingly the linear accelerators are divided in three large groups: electrostatic, induction and RF accelerators. Overview of the different types of accelerators is given. Stability of longitudinal and transverse motion in the RF linear accelerators is briefly discussed. The methods of beam focusing in linacs are described.

  19. Progress towards the development of transient ram accelerator simulation as part of the U.S. Air Force Armament Directorate Research Program

    NASA Astrophysics Data System (ADS)

    Sinha, N.; York, B. J.; Dash, S. M.; Drabczuk, R.; Rolader, G. E.

    1992-07-01

    This paper describes the development of an advanced CFD simulation capability in support of the U.S. Air Force Armament Directorate's ram accelerator research initiative. The state-of-the-art CRAFT computer code has been specialized for high fidelity, transient ram accelerator simulations via inclusion of generalized dynamic gridding, solution adaptive grid clustering, high pressure thermochemistry, etc. Selected ram accelerator simulations are presented which serve to exhibit the CRAFT code's capabilities and identify some of the principal research/design issues.

  20. Expert system for scheduling simulation lab sessions

    NASA Technical Reports Server (NTRS)

    Lund, Chet

    1990-01-01

    Implementation and results of an expert system used for scheduling session requests for the Systems Engineering Simulator (SES) laboratory at the NASA Johnson Space Center (JSC) are discussed. Weekly session requests are received from astronaut crew trainers, procedures developers, engineering assessment personnel, software developers, and various others who wish to access the computers, scene generators, and other simulation equipment available to them in the SES lab. The expert system under discussion is comprised of a data acquisition portion - two Pascal programs run on a personal computer - and a CLIPS program installed on a minicomputer. A brief introduction to the SES lab and its scheduling background is given. A general overview of the system is provided, followed by a detailed description of the constraint-reduction process and of the scheduler itself. Results from a ten-week trial period using this approach are discussed. Finally, a summary of the expert system's strengths and shortcomings are provided.

  1. Recent Developments on ALICE (Accelerators and Lasers In Combined Experiments) at Daresbury Laboratory

    SciTech Connect

    Saveliev, Y M; Buckley, R K; Buckley, S R; Clarke, J A; Corlett, P A; Dunning, D J; Goulden, A R; Hill, S F; Jackson, F; Jamison, S P; Jones, J K; Jones, L B; Leonard, S; McIntosh, P A; McKenzie, J W; Middleman, K J; Militsyn, B L; Moss, A J; Muratori, B D; Orrett, J F; Pattalwar, S M; Phillips, P J; Scott, D J; Seddon, E A; Shepherd, B.J.A.; Smith, S L; Thompson, N; Wheelhouse, A E; Williams, P H; Harrison, P; Holder, D J; Holder, G M; Schofield, A L; Weightman, P; Williams, R L; Laundry, D; Powers, T; Priebe, G; Surman, M

    2010-05-01

    Progress made in ALICE (Accelerators and Lasers In Combined Experiments) commissioning and a summary of the latest experimental results are presented in this paper. After an extensive work on beam loading effects in SC RF linac (booster) and linac cavities conditioning, ALICE can now operate in full energy recovery mode at the bunch charge of 40pC, the beam energy of 30MeV and train lengths of up to 100us. This improved operation of the machine resulted in generation of coherently enhanced broadband THz radiation with the energy of several tens of uJ per pulse and in successful demonstration of the Compton Backscattering x-ray source experiment. The next steps in the ALICE scientific programme are commissioning of the IR FEL and start of the research on the first non-scaling FFAG accelerator EMMA. Results from both projects will be also reported.

  2. A small scale accelerator driven subcritical assembly development and demonstration experiment at LAMPF

    SciTech Connect

    Wender, S.A.; Venneri, F.; Bowman, C.D.; Arthur, E.D.; Heighway, E.A.; Beard, C.A.; Bracht, R.R.; Buksa, J.J.; Chavez, W.; DeVolder, B.G.

    1994-10-01

    A small scale experiment is described that will demonstrate many of the aspects of accelerator-driven transmutation technology. This experiment uses the high-power proton beam from the Los Alamos Meson Physics Facility accelerator and will be located in the Area-A experimental hall. Beam currents of up to 1 mA will be used to produce neutrons with a molten lead target. The target is surrounded by a molten salt and graphite moderator blanket. Fissionable material can be added to the molten salt to demonstrate plutonium burning or transmutation of commercial spent fuel or energy production from thorium. The experiment will be operated at power levels up to 5 MW{sub t}.

  3. Development and analysis of a metal-fueled accelerator-driven burner

    SciTech Connect

    Lypsch, F.; Hill, R. N.

    1995-09-15

    The purpose of this paper is to compare the safety characteristics of an accelerator driven metal-fueled fast system to a critical core on a consistent basis to determine how these characteristics are affected solely by subcriticality of the system. To accomplish this, an accelerator proton beam/tungsten neutron source model is surrounded by a subcritical blanket using metallic fuel and sodium as coolant. The consequences of typical accident transients, namely unprotected transient overpower (TOP), loss of heat sink (LOHS), and loss of flow (LOF) were calculated for the hybrid system and compared to corresponding results for a metal-fueled fast reactor. Results indicate that the subcritical system exhibits superior performance for TOP (reactivity-induced) transients; however, only in the critical system are reactivity feedbacks able to cause passive shutdown in the LOHS and LOF events. Therefore, for a full spectrum of accident initiators considered, the overall safety behavior of accelerator-driven metal-fueled systems can neither be concluded to be worse nor to be better than advanced reactor designs which rely on passive safety features.

  4. Development and analysis of a metal-fueled accelerator-driven burner

    SciTech Connect

    Lypsch, F.; Hill, R.N.

    1994-08-01

    The purpose of this paper is to compare the safety characteristics of an accelerator driven metal fueled fast system to a critical core on a consistent basis to determine how these characteristics are affected solely by subcritically of the system. To accomplish this an accelerator proton beam/tungsten neutron source model is surrounded by a subcritical blanket using metallic fuel and sodium as coolant. The consequences of typical accident transients, namely unprotected transient overpower (TOP), loss of heat sink (LOHS), and loss of flow (LOP) were calculated for the hybrid system and compared to corresponding results for a metal-fueled fast reactor. Results indicate that the subcritical system exhibits superior performance for TOP (reactivity-induced) transits; however, only in the critical system are reactivity feedbacks able to cause passive shutdown in the LOHS ad LOP events. Therefore, for a full spectrum of accident initiators considered, the overall safety behavior of accelerator-driven metal-fueled systems can neither be concluded to be worse nor to be better than advanced reactor designs which rely on passive safety features.

  5. Innovative Session 2. [Concurrent Innovative Session at AHRD Annual Conference, 2000.

    ERIC Educational Resources Information Center

    2000

    Two presentations are provided from Innovative Session 2 of the Academy of Human Resource Development (HRD) 2000 Conference proceedings. "Training Companies Speak Out on HRD Industry Changes: Symposium Introduction" (R. Wayne Pace) describes how this symposium explores the process of consolidation in the field, how the Internet is being used to…

  6. Recent progress in the development of a circular ion induction accelerator for space charge dominated beams at LLNL

    SciTech Connect

    Ahle, L; Autrey, D; Barnard, J; Berners, D; Craig, G; Debeling, A; Eylon, S; Friedman, A; Fritz, W; Grote, D P; Halaxa, E; Hanks, R L; Hernandez, M; Judd, D L; Kirbie, H C; Logan, B G; Lund, S M; Mant, G; Molvik, A W; Reginato, L; Sangster, T C; Sharp, W M

    1998-08-19

    The Heavy Ion Fusion Group at Lawrence Livermore National Laboratory has for several years been developing the world's first circular ion induction accelerator. This machine has recently been extended to 90 degrees, or 10 half-lattice periods (HLP) with full beam transport. In addition, induction cores have been installed on five of the HLP's, each with an independent arbitrary waveform pulser. An arbitrary waveform pulser for the bending electrostatic dipoles has also been enabled. Together, they have allowed the first attempts at coordinated bending and acceleration of the beam. The results of these first attempts will be reported on in the paper by examining the output of various diagnostic devices, such as the capacitive Beam Probes (C-probes), slit scanners, and the Gated Beam Imager(GBI).

  7. Session: Parabolic Troughs (Presentation)

    SciTech Connect

    Kutscher, C.

    2008-04-01

    The project description is R and D activities at NREL and Sandia aimed at lowering the delivered energy cost of parabolic trough collector systems and FOA awards to support industry in trought development. The primary objectives are: (1) support development of near-term parabolic trought technology for central station power generation; (2) support development of next-generation trought fields; and (3) support expansion of US trough industry. The major FY08 activities were: (1) improving reflector optics; (2) reducing receiver heat loss (including improved receiver coating and mitigating hydrogen accumulation); (3) measuring collector optical efficiency; (4) optimizing plant performance and reducing cost; (5) reducing plant water consumption; and (6) directly supporting industry needs, including FOA support.

  8. Introduction to Session 5

    NASA Astrophysics Data System (ADS)

    Zullo, Luca; Snyder, Seth W.

    Production of bio-based products that are cost competitive in the market place requires well-developed operations that include innovative processes and separation solutions. Separations costs can make the difference between an interesting laboratory project and a successful commercial process. Bioprocessing and separations research and development addresses some of the most significant cost barriers in production of bioffuels and bio-based chemicals. Models of integrated biorefineries indicate that success will require production of higher volume fuels in conjunction with high margin chemical products. Addressing the bioprocessing and separations cost barriers will be critical to the overall success of the integrated biorefinery.

  9. The direction of acceleration

    NASA Astrophysics Data System (ADS)

    Wilhelm, Thomas; Burde, Jan-Philipp; Lück, Stephan

    2015-11-01

    Acceleration is a physical quantity that is difficult to understand and hence its complexity is often erroneously simplified. Many students think of acceleration as equivalent to velocity, a ˜ v. For others, acceleration is a scalar quantity, which describes the change in speed Δ|v| or Δ|v|/Δt (as opposed to the change in velocity). The main difficulty with the concept of acceleration therefore lies in developing a correct understanding of its direction. The free iOS app AccelVisu supports students in acquiring a correct conception of acceleration by showing acceleration arrows directly at moving objects.

  10. Summary report of session VI

    SciTech Connect

    Weiren Chou et al.

    2002-08-19

    This report gives a brief review of the presentations in Session VI of the Ecloud'02 Workshop and summarizes the major points during the discussions. Some points (e.g., the critical mass phenomenon) are not conclusive and even controversial. But it has been agreed that further investigations are warranted. The topic of Session VI in the Ecloud'02 workshop is ''Discussions of future studies, collaborations and possible solutions.'' Half of the session is devoted to presentations, another half to discussions. This report will focus on the latter. There are six presentations: (1) R. Macek, Possible cures to the e-cloud problem; (2) G. Rumolo, Driving the electron-cloud instability by an electron cooler; (3) U. Iriso Ariz, RF test benches for electron-cloud studies; (4) F. Caspers, Stealth clearing electrodes; (5) F. Ruggiero, Future electron-cloud studies at CERN; and (6) E. Perevedentsev, Beam-beam and transverse impedance model.

  11. Critical Thinking in HRD--A Panel Led Discussion. Innovative Session.

    ERIC Educational Resources Information Center

    Elliott, Carole; Turnbull, Sharon

    A panel of 11 human resource development (HRD) practitioners (2 session chairs and 9 panelists) participated in an innovation session devoted to critical thinking in HRD. The session objectives were as follows: (1) share knowledge, views, and beliefs about the relevance of critical management theory and research to the HRD community; (2) provide a…

  12. Sessions Focus on Diversity

    NASA Astrophysics Data System (ADS)

    Adamec, Bethany Holm

    2013-01-01

    Education and outreach play a significant role in AGU's mission; one of our major strategic goals is developing and nurturing the next generation of Earth and space scientists. Particular emphasis is placed on exploring ways to strengthen the numbers and diversity of the Earth and space science workforce and helping to strengthen Earth and space science departments and undergraduate teaching at the college and university levels.

  13. Semi-Automated Discovery of Application Session Structure

    SciTech Connect

    Kannan, J.; Jung, J.; Paxson, V.; Koksal, C.

    2006-09-07

    While the problem of analyzing network traffic at the granularity of individual connections has seen considerable previous work and tool development, understanding traffic at a higher level---the structure of user-initiated sessions comprised of groups of related connections---remains much less explored. Some types of session structure, such as the coupling between an FTP control connection and the data connections it spawns, have prespecified forms, though the specifications do not guarantee how the forms appear in practice. Other types of sessions, such as a user reading email with a browser, only manifest empirically. Still other sessions might exist without us even knowing of their presence, such as a botnet zombie receiving instructions from its master and proceeding in turn to carry them out. We present algorithms rooted in the statistics of Poisson processes that can mine a large corpus of network connection logs to extract the apparent structure of application sessions embedded in the connections. Our methods are semi-automated in that we aim to present an analyst with high-quality information (expressed as regular expressions) reflecting different possible abstractions of an application's session structure. We develop and test our methods using traces from a large Internet site, finding diversity in the number of applications that manifest, their different session structures, and the presence of abnormal behavior. Our work has applications to traffic characterization and monitoring, source models for synthesizing network traffic, and anomaly detection.

  14. Practical Session: Introduction to R

    NASA Astrophysics Data System (ADS)

    Clausel, M.; Grégoire, G.

    2014-12-01

    An introduction to R is proposed. This pratical session is an excerpt from practical exercises proposed by A. Dalalyan at EPNC (see href="http://certis.enpc.fr/~dalalyan/Download/TP_ENPC_1.pdf). Datas are also extracted from a practical session proposed by hydrologic data from Amazonia proposed by D. Chessel A.B. Dufour in Lyon 1 (website indicated in the text below) and from other practical exercises proposed by A. Dalalyan at ENPC (same address as above but ended by /TP_ENPC_4.pdf).

  15. Interactive TV on parliament session

    NASA Astrophysics Data System (ADS)

    Royer, J.; Nguyen, H.; Martinot, O.; Preda, M.; Preteux, F.; Zaharia, T.

    2007-09-01

    This paper introduces a new interactive mobile TV application related to parliament session. This application aims to provide additional information to mobile TV users by inserting automatically and in real-time interactive contents (complementary information, subject of the current session...) into original TV program, using MPEG-4 streaming video and extra real time information (news, events, databases... from RSS streams, Internet links...). Here, we propose an architecture based on plug-in multimedia analyzers to generate the contextual description of the media and on an interactive scene generator to dynamically create related interactive scenes. Description is implemented according to the MPEG-7 standard.

  16. PARTICLE ACCELERATOR

    DOEpatents

    Teng, L.C.

    1960-01-19

    ABS>A combination of two accelerators, a cyclotron and a ring-shaped accelerator which has a portion disposed tangentially to the cyclotron, is described. Means are provided to transfer particles from the cyclotron to the ring accelerator including a magnetic deflector within the cyclotron, a magnetic shield between the ring accelerator and the cyclotron, and a magnetic inflector within the ring accelerator.

  17. Status of development of actinide blanket processing flowsheets for accelerator transmutation of nuclear waste

    SciTech Connect

    Dewey, H.J.; Jarvinen, G.D.; Marsh, S.F.; Schroeder, N.C.; Smith, B.F.; Villarreal, R.; Walker, R.B.; Yarbro, S.L.; Yates, M.A.

    1993-09-01

    An accelerator-driven subcritical nuclear system is briefly described that transmutes actinides and selected long-lived fission products. An application of this accelerator transmutation of nuclear waste (ATW) concept to spent fuel from a commercial nuclear power plant is presented as an example. The emphasis here is on a possible aqueous processing flowsheet to separate the actinides and selected long-lived fission products from the remaining fission products within the transmutation system. In the proposed system the actinides circulate through the thermal neutron flux as a slurry of oxide particles in heavy water in two loops with different average residence times: one loop for neptunium and plutonium and one for americium and curium. Material from the Np/Pu loop is processed with a short cooling time (5-10 days) because of the need to keep the total actinide inventory, low for this particular ATW application. The high radiation and thermal load from the irradiated material places severe constraints on the separation processes that can be used. The oxide particles are dissolved in nitric acid and a quarternary, ammonium anion exchanger is used to extract neptunium, plutonium, technetium, and palladium. After further cooling (about 90 days), the Am, Cm and higher actinides are extracted using a TALSPEAK-type process. The proposed operations were chosen because they have been successfully tested for processing high-level radioactive fuels or wastes in gram to kilogram quantities.

  18. Progress on laser plasma accelerator development using transverselyand longitudinally shaped plasmas

    SciTech Connect

    Leemans, Wim P.; Esarey, E.; Geddes, C.G.R.; Toth, Cs.; Schroeder, C.B.; Nakamura, K.; Gonsalves, A.J.; Panasenko, D.; Cormier-Michel, E.; Plateau, G.R.; Lin, C.; Bruhwiler, D.L.; Cary, J.R.

    2009-03-31

    A summary of progress at Lawrence Berkeley National Laboratory is given on: (1) experiments on down-ramp injection; (2) experiments on acceleration in capillary discharge plasma channels; and (3) simulations of a staged laser wakefield accelerator (LWFA). Control of trapping in a LWFA using plasma density down-ramps produced electron bunches with absolute longitudinal and transverse momentum spreads more than ten times lower than in previous experiments (0.17 and 0.02 MeV Ic FWHM, respectively) and with central momenta of 0.76 +- 0.02 MeV Ic, stable over a week of operation. Experiments were also carried out using a 40 TW laser interacting with a hydrogen-filled capillary discharge waveguide. For a 15 mm long, 200 mu m diameter capillary, quasi-monoenergetic bunches up to 300 MeV were observed. By detuning discharge delay from optimum guiding performance, self-trapping was found to be stabilized. For a 33 mm long, 300 mu m capillary, a parameter regime with high energy bunches, up to 1 Ge V, was found. In this regime, peak electron energy was correlated with the amount of trapped charge. Simulations show that bunches produced on a down-ramn and iniected into a channel-guided LWFA can produce stable beams with 0.2 MeV Ic-class momentum spread at high energies.

  19. Proof-of-concept development of PXAMS (projectile x-ray accelerator mass spectrometry)

    SciTech Connect

    Proctor, I.D.; Roberts, M.L.; McAninch, J.E.; Bench, G.S.

    1996-03-01

    Prior to the current work, accelerator mass spectrometry (AMS) was limited to a set of {approximately}8--10 isotopes. This limitation is caused primarily by the inability to discriminate against stable atomic isobars. An analysis scheme that combines the isotopic sensitivity of AMS with similar isobar selectivity would open a large new class of isotope applications. This project was undertaken to explore the use of characteristic x rays as a method for the detection and identification of ions,and to allow the post-spectrometer rejection of isobaric interferences for isotopes previously inaccessible to AMS. During the second half of FY94 (with Advanced Concepts funding from the Office of Non-Proliferation and National Security), we examined the feasability of this technique, which we are referring to as PXAMS (Projectile X ray AMS), to the detection of several isotopes at Lawrence Livermore National Laboratory (LLNL). In our first exploratory work, we measured the x ray yield vs energy for {sup 80}Se ions stopped in a thick Y target. These results, demonstrated that useful detection efficiencies could be obtained for Se ions at energies accessible with our accelerator, and that the count rate from target x rays is small compared to the Se K{alpha} rate. We followed these measurements with a survey of x ray yields for Z = 14-46.

  20. State-of-the-Art developments in accelerator controls at the APS.

    SciTech Connect

    Lenkszus, F.

    1999-04-13

    The performance requirements of the Advanced Photon Source (APS) challenge the control system in a number of areas. This paper will review a few applications of advanced technology in the control and monitoring of the APS. The application of digital signal processors (DSPs) and techniques will be discussed, both from the perspective of a large distributed multiprocessor system and from that of embedded systems. In particular, two embedded applications will be highlighted, a beam position monitor processor and a DSP-based power supply controller. Fast data distribution is often a requirement. The application of a high-speed network based on reflective memory will also be discussed in the context of the APS global orbit feedback system. Timing systems provide opportunities to apply technologies such as high-speed logic and fiber optics. Examples of the use of these technologies will also be included. Finally, every modern accelerator control system of any size requires networking. Features of the APS accelerator controls network will be discussed.

  1. Wrap-up session

    NASA Technical Reports Server (NTRS)

    Holland, Geoffrey

    1992-01-01

    Listening to the case studies that were presented it became quite evident that the best data management systems were the ones where data managers and research scientists worked as a team developed in the early stages of project planning. Examples that were given included WOCE Data Assembly Centres e.g., Drifters, the Global Temperature Salinity Pilot Project (GTSPP) collaboration with Joint Analyses Centres in the U.S. and Australia, and JGOFS/BOFS development of Topical Centres. While each of these has some elements unique to the project, each had brought together 'teams' of Principal Investigators (PI's) and data management experts at an early stage of project development. Conversely, projects which had considered data management as a totally separate activity with lower priority often failed to provide the service required to meet scientific objectives. Therefore, the following actions should be brought to the attention of relevant groups within the IOC and other international organizations: (1) Publicize, at the national and international level, underway data/scientist collaborations that may be used as models in planning for the future. (2) Reduce adversarial situations where data managers and scientists appear to be in competition. (3) Colocation and other forms of collaboration often results in very high quality data sets and more timely data submission. Improved timeliness of data submissions was a common theme throughout the workshop and must be considered an important element in all future plans. Improvements in timely submission of data were noted. In order to continue this trend the advantages of timely submission of data must be stressed to those planning new ocean science projects.

  2. Using combinatorial bioinformatics methods to analyze annual perspective changes of influenza viruses and to accelerate development of effective vaccines.

    PubMed

    Hu, Yu-Jen; Chow, Kuan-Chih; Liu, Ching-Chuan; Lin, Li-Jen; Wang, Sheng-Cheng; Wang, Shulhn-Der

    2015-08-01

    The standard World Health Organization procedure for vaccine development has provided a guideline for influenza viruses, but no systematic operational model. We recently designed a systemic analysis method to evaluate annual perspective sequence changes of influenza virus strains. We applied dnaml of PHYLIP 3.69, developed by Joseph Felsenstein of Washington University, and ClustalX2, developed by Larkin et al, for calculating, comparing, and localizing the most plausible vaccine epitopes. This study identified the changes in biological sequences and associated alignment alterations, which would ultimately affect epitope structures, as well as the plausible hidden features to search for the most conserved and effective epitopes for vaccine development. Addition our newly designed systemic analysis method to supplement the WHO guidelines could accelerate the development of urgently needed vaccines that might concurrently combat several strains of viruses within a shorter period. PMID:26044364

  3. Accelerator development for the NRL (Naval Research Laboratory) free-electron-laser program. Final report, July 1981-April 1986

    SciTech Connect

    Lucey, R.; Putnam, S.

    1988-06-01

    Included in the report are descriptions of the final assembly and operation of the Linear Induction Accelerator(LIA), installation and testing of a new accelerating gap in the five-core stage of the accelerator to operate at 150 kV, and the moving of and modifications of the charging and firing controls for remote operation of the accelerator.

  4. Final Plenary Session Transcript

    NASA Technical Reports Server (NTRS)

    Gostelow, Paul

    2010-01-01

    Let s start with the report - as you know - when we are talking about flow control it is a multi-disciplinary type of work. So it involves many people and disciplines. This group first discussed the important issues associated with flow control. As you start doing flow control what are the issues to which you really have to start paying attention? That is the first part I am going to present. Then in the second part I will present some challenges - problems that we should really be looking at. So as far as the issues - if you want to control a flow, you really need to understand the flow physics, because anything that you do comes from the flow physics. The design of the controllers, your decisions on the actuators, sensors, reduced order modeling and all of that, would be helped if you understand flow physics. And you have to have a specific objective - what exactly are you controlling? Are you trying to reduce drag, eliminate separation, reduce noise, enhance mixing? So you have to have very specific control objectives. From all the talks we have seen here actuation is extremely important and it is very problem specific. It depends on what problem you are dealing with so you have to design and build actuators for that specific problem. Sensors obviously are very important, especially when you are dealing with feedback control. Consensus was that when you dealing with flow control, you must take an integrated approach; from the beginning you have to take into account every aspect of it and even maybe to modify your experiment, your geometry, to go along with the actuation, sensors and control models. Development of tools is very important in this multi-disciplinary problem. The tools include CFD, reduced order modeling, controller design, understanding and utilizing the instabilities of the flow, etc. So, in order to have success in flow control, we really need to develop these tools.

  5. The potential investment impact of improved access to accelerated approval on the development of treatments for low prevalence rare diseases

    PubMed Central

    2011-01-01

    Background Over 95% of rare diseases lack treatments despite many successful treatment studies in animal models. To improve access to treatments, the Accelerated Approval (AA) regulations were implemented allowing the use of surrogate endpoints to achieve drug approval and accelerate development of life-saving therapies. Many rare diseases have not utilized AA due to the difficulty in gaining acceptance of novel surrogate endpoints in untreated rare diseases. Methods To assess the potential impact of improved AA accessibility, we devised clinical development programs using proposed clinical or surrogate endpoints for fifteen rare disease treatments. Results We demonstrate that better AA access could reduce development costs by approximately 60%, increase investment value, and foster development of three times as many rare disease drugs for the same investment. Conclusion Our research brings attention to the need for well-defined and practical qualification criteria for the use of surrogate endpoints to allow more access to the AA approval pathway in clinical trials for rare diseases. PMID:21733145

  6. AIRIX: an induction accelerator facility developed at CEA for flash radiography in detonics

    NASA Astrophysics Data System (ADS)

    Cavailler, Claude

    1999-06-01

    AIRIX is an induction linear accelerator which will be used for flash radiography in CEA/DAM. Designed to produce an X-ray dose of more than 500 Rads at 1 meter with an X-ray focal spot size diameter of less than 2 mm (LANL-CEA DAM definition), this facility consists in a 4 MeV/3.5 kA pulsed electron injector and 16 MeV induction accelerator powered by 32 high voltage generators. A prototype of this accelerator, called PIVAIR, has been studied and realized in CEA CESTA near Bordeaux. PIVAIR is a validation step for AIRIX at 8 MeV. It includes an injector (4 MeV, 3.5 kA, 60 ns) and 16 inductor cells supplied by 8 high voltage generators (250 kV, 70 ns). Two different technologies of induction cells have been tested (rexolite insulator or ferrite under vacuum). We have chosen ferrite under vacuum cells technology after comparison of results on beam transport and reliability tests. A focusing experiment at 7.2 MeV of the electron beam as been achieved during summer 1997. We have begun to produce X-rays in October 1997. A dose level of 50 Rad at 1 meter has been achieved with an X-ray spot size diameter of 3.5 to 4 mm (LANL-CEA DAM definition). Static flash radiography of very dense object have been achieved from November 97 until February 98. We have been able to test in situ new kinds of very high sensitive X- ray detectors and to check they had reached our very ambitious goals: (1) quantum efficiency at 5 MeV greater than 50% instead of 1% for luminous screens and film; (2) sensitivity less than 10 (mu) Rad (100 time more sensitive than radiographic luminous screens and films); (3) dynamic range greater than 100; (4) resolution less than 2 mm. We will present in this communication brand new kinds of detection systems, called high stopping power detectors, such as: (1) (gamma) camera with segmented thick crystal of BGO and MCP image intensifier; (2) multistep parallel plate avalanche chamber; (3) pixellized CdTe MeV photoconductor matrix. AIRIX accelerator is being

  7. Introduction to Session 1A

    NASA Astrophysics Data System (ADS)

    Himmel, Michael E.

    Understanding and overcoming the natural resistance of plant cell walls to enzymatic hydrolysis remains one of the most active research areas in biofuels production (as indicated by the number of abstracts and papers submitted to this session). A number of the oral presentations given during the Enzyme Catalysis and Engineering session highlighted the use of new and innovative tools for advancing our understanding of plant cell wall deconstruction. The oral presentations and posters given for this session included applications of imaging tools and computational models to advance our understanding of biomass recalcitrance relative to enzymatic deconstruction. This session was opened with a presentation by Dr. Danny Akin, who outlined the structural and chemical barriers for the bioconversion of grasses to sugars. Lignocelluloses from grasses, such as switch grass, are resistant to bioconversion by various aromatic constituuents, which include both lignins and phenolic acid esters. However, Akin and coworkers demonstrated the use of selected white rot fungal enzymes, which lack cellulases that could be used to produce delignified lignocellulosic materials, resulting in improved bioconversion.

  8. Poster Session B

    PubMed Central

    2014-01-01

    B.1 Development of a Proximity Labeling Method to Identify the Protein Targets of Bioactive Small Molecules Zachary Hill, Min Zhuang, James Wells University of California, San Francisco, CA, USA Identifying the direct protein targets of a bioactive small molecule gives insight into the compound's mechanism of action, its efficacy, and possible toxicity. Target identification is becoming an increasingly important part of the drug- development process. However, given the transient and heterogeneous nature of interactions between small molecules and proteins, this step is often difficult, greatly slowing the development of new therapeutics. For this reason, new methods to rapidly identify the direct protein targets of bioactive small molecules are of great importance. Enrichment strategies coupled with quantitative mass spectrometry have shown great promise in target identification. Here we will present our progress toward developing an engineered enzymatic tagging method that enables specific labeling and enrichment of protein targets from complex lysates. This method couples the binding of a small molecule to a proximity-based labeling event. Labeled target proteins are enriched and subsequently identified using quantitative LC-MS/MS. We will discuss several variations of this method, and highlight our progress towards applying proximity labeling to small-molecule target identification and validation. B.2 Modelling Atherosclerosis: Molecular Changes in the Ascending Aorta of Cholesterol-fed Rabbits Jingshu Xu1,2, Mia Jüllig1,2, Martin J. Middleditch1,2, Garth J.S. Cooper1,2,3,4 1School of Biological Sciences, University of Auckland, New Zealand; 2Maurice Wilkins Centre for Molecular Biodiscovery, Faculty of Science, University of Auckland, New Zealand; 3Department of Pharmacology, Medical Sciences Division, University of Oxford, Oxford, UK; 4Centre for Advanced Discovery and Experimental Therapeutics, NIHR Manchester Biomedical Research Centre, the University of

  9. High-speed Rail Development Act of 1994. Introduced in the House of Representatives, One Hundred Third Congress, Second Session, August 10, 1994

    SciTech Connect

    1994-12-31

    The House report on H. R. 4867, the High-Speed Rail Development Act of 1994, authorizes activities to assist in the implementation of steel-wheel high-speed rail transportation. The Bill authorizes preconstruction activities for corridor planning.

  10. Poster Session A

    PubMed Central

    2014-01-01

    A.1 Lessons Learned During Eight Years of Using iTRAQ in the Proteomic Study of Pathology Mia Jullig1, Martin Middleditch1, Garth Cooper1,2 1Maurice Wilkins Centre, University of Auckland, Auckland, New Zealand; 2University of Manchester, UK Our research team has long held the view that proteomics holds the key to unlock pathology. During the past eight years we have increasingly used the LC-MS/MS based iTRAQ labeling approach to further our understanding of a number of pathologies in various tissues of interest. From our very first project utilizing iTRAQ, it became clear that manual processing of the LC-MS/MS output to obtain protein ratios is preferable to using the ratios automatically generated by proprietary quantitative proteomic software. For example, we have identified two relatively common amino acid patterns which generate MS/MS m/z values overlapping with those of certain iTRAQ reporter ions and, if not accounted for, may interfere with the quantitative results. Furthermore, systematically different degrees of missed tryptic cleavages between study groups may skew the results since miscleaved peptides are often less suitable for detection through LC-MS/MS. Other factors which may compromise the relative quantitation include variable success in depleting biofluids e.g. plasma of highly abundant proteins, and large change in abundance of one or more highly abundant proteins in disease. We are continually developing strategies to overcome these issues. It is however clear that each new tissue and pathology comes with its own challenges, highlighting the need for a tailored approach for each project rather than the application of a general formula. We here present our current approach to manual handling of LC-MS/MS data from iTRAQ labeled samples, along with a number of cases illustrating the potential pitfalls above and demonstrate how these can be managed. A.2 Whole Animal 15N Metabolic Pulse Chase Labeling Shows which Proteins are Built to Last Jeffrey

  11. Upgrade of the MIT Linear Electrostatic Ion Accelerator (LEIA) for nuclear diagnostics development for Omega, Z and the NIF

    SciTech Connect

    Sinenian, N.; Manuel, M. J.-E.; Zylstra, A. B.; Rosenberg, M.; Waugh, C. J.; Rinderknecht, H. G.; Casey, D. T.; Sio, H.; Ruszczynski, J. K.; Zhou, L.; Johnson, M. Gatu; Frenje, J. A.; Seguin, F. H.; Li, C. K.; Petrasso, R. D.; Ruiz, C. L.; Leeper, R. J.

    2012-04-15

    The MIT Linear Electrostatic Ion Accelerator (LEIA) generates DD and D{sup 3}He fusion products for the development of nuclear diagnostics for Omega, Z, and the National Ignition Facility (NIF). Significant improvements to the system in recent years are presented. Fusion reaction rates, as high as 10{sup 7} s{sup -1} and 10{sup 6} s{sup -1} for DD and D{sup 3}He, respectively, are now well regulated with a new ion source and electronic gas control system. Charged fusion products are more accurately characterized, which allows for better calibration of existing nuclear diagnostics. In addition, in situ measurements of the on-target beam profile, made with a CCD camera, are used to determine the metrology of the fusion-product source for particle-counting applications. Finally, neutron diagnostics development has been facilitated by detailed Monte Carlo N-Particle Transport (MCNP) modeling of neutrons in the accelerator target chamber, which is used to correct for scattering within the system. These recent improvements have resulted in a versatile platform, which continues to support the existing nuclear diagnostics while simultaneously facilitating the development of new diagnostics in aid of the National Ignition Campaign at the National Ignition Facility.

  12. Limits of NbTi and Nb3Sn, and development of W& R Bi-2212 High Field Accelerator Magnets

    SciTech Connect

    Cheng, Daniel; Dietderich, Daniel; Ferrracin, Paolo; Prestemon, Soren; Sabbi, GianLuca; Scanlan, Ron; Godeke, A.

    2007-06-01

    NbTi accelerator dipoles are limited to magnetic fields (H) of about 10 T, due to an intrinsic upper critical field (H{sub c2}) limitation of 14 T. To surpass this restriction, prototype Nb{sub 3}Sn magnets are being developed which have reached 16 T. We show that Nb{sub 3}Sn dipole technology is practically limited to 17 to 18 T due to insufficient high field pinning, and intrinsically to 20 to 22 T due to H{sub c2} limitations. Therefore, to obtain magnetic fields approaching 20 T and higher, a material is required with a higher H{sub c2} and sufficient high field pinning capacity. A realistic candidate for this purpose is Bi-2212, which is available in round wires and sufficient lengths for the fabrication of coils based on Rutherford-type cables. We initiated a program to develop the required technology to construct accelerator magnets from 'wind-and-react' (W&R) Bi-2212 coils. We outline the complications that arise through the use of Bi-2212, describe the development paths to address these issues, and conclude with the design of W&R Bi-2212 sub-scale magnets.

  13. Saturated humidity accelerates lateral root development in rice (Oryza sativa L.) seedlings by increasing phloem-based auxin transport.

    PubMed

    Chhun, Tory; Uno, Yuichi; Taketa, Shin; Azuma, Tetsushi; Ichii, Masahiko; Okamoto, Takashi; Tsurumi, Seiji

    2007-01-01

    Auxin transport plays a significant role modifying plant growth and development in response to environmental signals such as light and gravity. However, the effect of humidity on auxin transport is rarely documented. It is shown here that the transport of labelled indole-3-acetic acid (IAA) from the shoot to the root is accelerated in rice (Oryza sativa L. ssp. indica cv. IR8) seedlings grown under saturated humidity (SH-seedlings) compared with plants grown under normal humidity (NH-seedlings). The development of lateral roots in SH-seedlings was greatly enhanced compared with NH-seedlings. Removal of the shoot from SH-seedlings reduced the density of lateral roots, and the application of IAA to the cut stem restored the lateral root density, while the decapitation of NH-seedlings did not alter lateral root development. Phloem-based auxin transport appeared responsible for enhanced lateral root formation in SH-seedlings since (i) the rate of IAA transport from the shoot to the root tip was greater than 3.5 cm h-1 and (ii) naphthylphthalamic acid (NPA)-induced reduction of polar auxin transport in the shoot did not influence the number of lateral roots in SH-seedlings. It is proposed that high humidity conditions accelerate the phloem-based transport of IAA from the leaf to the root, resulting in an increase in the number of lateral roots. PMID:17383991

  14. Session: Monitoring wind turbine project sites for avian impacts

    SciTech Connect

    Erickson, Wally

    2004-09-01

    This third session at the Wind Energy and Birds/Bats workshop consisted of one presentation followed by a discussion/question and answer period. The focus of the session was on existing wind projects that are monitored for their impacts on birds and bats. The presentation given was titled ''Bird and Bat Fatality Monitoring Methods'' by Wally Erickson, West, Inc. Sections included protocol development and review, methodology, adjusting for scavenging rates, and adjusting for observer detection bias.

  15. Introduction of Break-Out Session 2 of the 2011 International PV Module Quality Assurance Forum(Presentation)

    SciTech Connect

    Wohlgemuth, J.; Kurtz, S.; Sample, T.; Yamamichi, M.

    2011-07-01

    This presentation outlines the goals and specific tasks of break-out session 2 of the 2011 International PV Module Quality Assurance Forum, along with a review of accelerated stress tests used for photovoltaics (PV).

  16. Using a Modified Intervention Mapping Approach to Develop and Refine a Single-Session Motivational Intervention for Methamphetamine-Using Men Who Have Sex With Men

    PubMed Central

    Zule, William A; Coomes, Curtis M; Karg, Rhonda; Harris, Jennie L; Orr, Alex; Wechsberg, Wendee M

    2010-01-01

    There is an ongoing need for the development and adaptation of behavioral interventions to address behaviors related to acquisition and transmission of infectious diseases and for preventing the onset of chronic diseases. This paper describes the application of an established systematic approach to the development of a behavioral intervention to reduce sexual risk behaviors for HIV among men who have sex with men and who use methamphetamine. The approach includes six steps: (1) a needs assessment; (2) preparing matrices of proximal program objectives; (3) selecting theory-based methods and practical strategies; (4) producing program components and materials; (5) planning for program adoption, implementation, and sustainability; and (6) planning for evaluation. The focus of this article is on the intervention development process; therefore the article does not describe steps 5 and 6. Overall the process worked well, although it had to be adapted to fit the sequence of events associated with a funded research project. This project demonstrates that systematic approaches to intervention development can be applied even in research projects where some of the steps occur during the proposal writing process rather than during the actual project. However, intervention developers must remain flexible and be prepared to adapt the process to the situation. This includes being ready to make choices regarding intervention efficacy versus feasibility and being willing to select the best intervention that is likely to be delivered with available resources rather than an ideal intervention that may not be practical. PMID:20657716

  17. Development and optimization of a beam shaper device for a mobile dedicated IOERT accelerator

    SciTech Connect

    Soriani, Antonella; Iaccarino, Giuseppe; Felici, Giuseppe; Ciccotelli, Alessia; Pinnaro, Paola; Giordano, Carolina; Benassi, Marcello; D'Andrea, Marco; Bellesi, Luca; Strigari, Lidia

    2012-10-15

    Purpose: The aim of this study was to design and build a prototype beam shaper to be used on a dedicated mobile accelerator that protects organs at risk within the radiation field and conforms the beam to the target geometry during intraoperative electron radiotherapy (IOERT). A dosimetric characterization of the beam shaper device was performed based on Monte Carlo (MC) simulations, as well as experimental data, at different energies, field sizes, and source to skin distances. Methods: A mobile light intraoperative accelerator (LIAC{sup Registered-Sign }, Sordina, Italy) was used. The design of the beam shaper prototype was based on MC simulations (BEAMnrc/OMEGA and DOSXYZnrc code) for a selection of materials and thicknesses, as well as for dosimetric characterization. Percentage depth dose (PDD) and profile measurements were performed using a p-type silicon diode and a commercial water phantom, while output factors were measured using a PinPoint ion chamber in a PMMA phantom. Planar doses in planes of interest were carried out using radiochromic films (Gafchromic{sup TM} EBT and EBT2) in PMMA and in a Solid Water{sup Registered-Sign} phantom. Several experimental set-ups were investigated with the beam shaper device fixed on the top of the phantom, varying both the short side of the rectangular field and the air gap between the device and the phantom surface, simulating the clinical situation. The output factors (OFs) were determined using different geometrical set-ups and energies. Results: The beam shaper prototype consists of four blades sliding alongside each other and mounted on a special support at the end of the 10 cm diameter PMMA circular applicator. Each blade is made of an upper layer of 2.6 cm of Teflon{sup Registered-Sign} and a lower layer of 8 mm of stainless steel. All rectangles inscribed in a 5 cm diameter can be achieved in addition to any 'squircle-shaped' field. When one side of the rectangular field is held constant and the second side is

  18. Energy and water development appropriations for 1985. Part 2. Hearings before the Committee on Appropriations, House of Representatives, Ninety-Eighth Congress, Second Session

    SciTech Connect

    Not Available

    1984-01-01

    Part 2 of the hearing record covers testimony given by the Corps of Engineers on the Lower Mississippi Valley, Southwestern, North Pacific, South Pacific, and Pacific Ocean Divisions, and by the Delaware and Susquehanna River Basin Commissions and the Interstate Commission on the Potomac River Basin. Representatives of the Corps' engineering, planning, and program development offices described projects in each of the divisions which relate to navigation, flood control, job development, and other matters. The Committee reviewed appropriation levels for each of the projects. The hearing record includes background and supporting documentation as well as the statements and testimony of the witnesses.

  19. Social Responsibility of Human Resource Development: How Our Definitions and Worldviews Impact Our Leadership Role. Town Forum. [Concurrent Town Forum Session at AHRD Annual Conference, 2000.

    ERIC Educational Resources Information Center

    Hatcher, Timothy G.; Brooks, Ann K.

    The question of whether human resource development (HRD) should assume a leadership role in social responsibility has not been seriously or rigorously addressed in the HRD literature. As a multidisciplinary field, HRD is influenced not only by societal needs but also by underlying disciplines, including economics, psychology, general systems,…

  20. Energy and water development appropriations for 1994. Hearings before the Subcommittee of the Committee on Appropriations, House of Representatives, One Hundred Third Congress, First Session, Part 3

    SciTech Connect

    Not Available

    1993-01-01

    This document of part 3 of the hearings for the Energy and Water Development Appropriations for 1994. This document contains the testimony of the Federal Energy Regulatory Commission, Nuclear Regulatory Commission, Bureau of Reclamation, the Secretary of the Interior, Susquehanna River Basin Commission, Delaware River Basin Commission, Interstate Commission on the Potomac River Basin, Tennessee Valley Authority, and Appalachian Regional Commission.

  1. Rural Development: Seventh Annual Report of the President to the Congress on Government Services to Rural America. 95th Congress, 1st Session.

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. House.

    Analyzing 1975 Federal Outlays for 275 programs in terms of rural development and government services, this 7th annual report to the Congress pursuant to Title IX, Section 901 (e) of the Agricultural Act of 1970 includes tabular and narrative data pertaining to: metropolitan and nonmetropolitan distribution; regional distribution (census regions);…

  2. Using Effective Professional Development Sessions to Implement Change in Curriculum and Classroom Practices: My Story as a Teacher at Exmouth District High School, WA's Remotest District High

    ERIC Educational Resources Information Center

    Bedford, Susie

    2005-01-01

    Teaching in a remote town has its drawbacks with regard to Professional Development (PD), which becomes extremely costly, so each staff member is probably limited to one decent PD once a year. This means choosing PD extremely carefully to ensure "value for money" and hopefully that it will provide the teacher concerned with…

  3. Educational Research, Development, and Dissemination Excellence Act. House of Representatives, 103d Congress, 1st Session. Report To Accompany H.R. 856.

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. House Committee on Education and Labor.

    The House Committee on Education and Labor reports on the bill (H.R. 856) to improve education in the United States by promoting excellence in research, development, and the dissemination of information. The committee reports favorably on the bill, with an amendment, and recommends that the House pass the bill as amended. Consideration of H.R. 856…

  4. Workforce Development Act of 1995. Report together with Additional and Minority Views To Accompany S.143. 104th Congress, 1st Session.

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. Senate Committee on Labor and Human Resources.

    This congressional report addresses the Workforce Development Act of 1995 that would consolidate federal employment training programs and create a new process and structure for funding the programs. Contents include the following: a summary of the bill; background and need for the legislation; history of the legislation and votes in committee;…

  5. USSR: Measures of Economic Growth and Development, 1950-80. Studies Prepared for the Use of the Joint Economic Committee, 97th Congress, Second Session.

    ERIC Educational Resources Information Center

    Joint Economic Committee, Washington, DC.

    Because the Soviet Union does not publish measures of economic growth and development comparable with those of Western countries, the Central Intelligence Agency has provided (by means of a large research effort carried out over many years) estimates of the value of the Soviet gross national product (GNP), its rate of growth, its size relative to…

  6. Domestic Violence, 1978; Hearings Before the Subcommittee On Child and Human Development of the Committee on Human Resources, United States Senate, Ninety-Fifty Congress, Second Session.

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. Senate Committee on Human Resources.

    This volume contains the transcripts from the 1978 Congressional hearings from the subcommittee on child and human development. Major topics focus on domestic violence and relevant legislation. Witnesses represented such organizaitons as State Departments of Health, Education and Welfare, the U.S. Senate, Comission on the Status of Women and the…

  7. Energy and water development appropriations for 1999: Part 3. Hearings before a Subcommittee of the Committee on Appropriations, House of Representatives, On Hundred Fifth Congress, Second Session

    SciTech Connect

    1998-12-31

    These are the hearings before the subcommittee on energy and water development of the committed on appropriations, House of Representatives. The topics include the Bureau of Reclamation, testimony of the Secretary of the Interior, Appalachian Regional Commission, and the Tennessee Valley Authority. The discussion is related to the funding of activities in these areas.

  8. Pre-design of MYRRHA, A Multipurpose Accelerator Driven System for Research and Development

    NASA Astrophysics Data System (ADS)

    D'hondt, P.; Abderrahim, H. Aït; Kupschus, P.; Malambu, E.; Aoust, Th.; Benoit, Ph.; Sobolev, V.; Van Tichelen, K.; Arien, B.; Vermeersch, F.; Jongen, Y.; Ternier, S.; Vandeplassche, D.

    2003-08-01

    One of the main SCK•CEN research facility, namely BR2, is nowadays arriving at an age of 40 years just like the major materials testing reactors (MTR) in the world and in Europe (i.e. BR2 (B-Mol), HFR (EU-Petten), OSIRIS (F-Saclay), R2 (S-Studsvik)). The MYRRHA facility in planning has been conceived as potentially replacing BR2 and to be a fast spectrum facility complementary to the thermal spectrum RJH (Réacteur Jules Horowitz) facility, in planning in France. This situation would give Europe a full research capability in terms of nuclear R&D. Furthermore, the disposal of radioactive wastes resulting from industrial nuclear energy production has still to find a fully satisfactory solution, especially in terms of environmental and social acceptability. Scientists are looking for ways to drastically reduce (by a factor of 100 or more) the radio-toxicity of the High Level Waste (HLW) to be stored in a deep geological repository. This can be achieved via burning of minor actinides (MA) and to a less extent of long-lived fission products (LLFP) in Accelerator Driven Systems. The MYRRHA project contribution will be in helping to demonstrate the ADS concept at reasonable power level and the demonstration of the technological feasibility of MA and LLFP transmutation under real conditions.

  9. Pre-design of MYRRHA, A Multipurpose Accelerator Driven System for Research and Development

    SciTech Connect

    D'hondt, P.; Abderrahim, H. Aiet; Kupschus, P.; Malambu, E.; Aoust, Th.; Benoit, Ph.; Sobolev, V.; Tichelen, K. van; Arien, B.; Vermeersch, F.; Jongen, Y.; Ternier, S.; Vandeplassche, D.

    2003-08-26

    One of the main SCKCEN research facility, namely BR2, is nowadays arriving at an age of 40 years just like the major materials testing reactors (MTR) in the world and in Europe (i.e. BR2 (B-Mol), HFR (EU-Petten), OSIRIS (F-Saclay), R2 (S-Studsvik)). The MYRRHA facility in planning has been conceived as potentially replacing BR2 and to be a fast spectrum facility complementary to the thermal spectrum RJH (Reacteur Jules Horowitz) facility, in planning in France. This situation would give Europe a full research capability in terms of nuclear R and D. Furthermore, the disposal of radioactive wastes resulting from industrial nuclear energy production has still to find a fully satisfactory solution, especially in terms of environmental and social acceptability. Scientists are looking for ways to drastically reduce (by a factor of 100 or more) the radio-toxicity of the High Level Waste (HLW) to be stored in a deep geological repository. This can be achieved via burning of minor actinides (MA) and to a less extent of long-lived fission products (LLFP) in Accelerator Driven Systems. The MYRRHA project contribution will be in helping to demonstrate the ADS concept at reasonable power level and the demonstration of the technological feasibility of MA and LLFP transmutation under real conditions.

  10. On the development of an ion-beam stochastic cooling system for the nuclotron superconducting accelerator complex

    NASA Astrophysics Data System (ADS)

    Kobets, A. G.; Sidorin, A. O.; Trubnikov, G. V.; Shurkhno, N. A.

    2012-07-01

    The Joint Institute for Nuclear Research (JINR) initiated the creation of a unique heavy-ion collider, the Nuclotron-based ion collider facility (NICA), which is planned to be put into commission in 2016. According to the calculation data, the collider luminosity, which should be kept at a record high level of 1027 cm-2 s-1, will gradually decrease, mainly due to intrabeam scattering. To maintain luminosity at a high level, it is necessary to include a cooling system in the base project of the accelerator. Among the two cooling methods (electron and stochastic) most frequently used for heavy ion beams, stochastic cooling seems more attractive. However, there has been a lack of experience in the development and commissioning of such systems in Russia. For this reason, an experiment on stochastic cooling on the Nuclotron accelerator is being prepared to explore the technology and possibilities of this method. In this work, the method of stochastic cooling, the technique for calculating the cooling dynamics, and the experimental setup under development are briefly described.

  11. Deficiency of Nuclear Factor-κB c-Rel Accelerates the Development of Autoimmune Diabetes in NOD Mice.

    PubMed

    Ramakrishnan, Parameswaran; Yui, Mary A; Tomalka, Jeffrey A; Majumdar, Devdoot; Parameswaran, Reshmi; Baltimore, David

    2016-08-01

    The nuclear factor-κB protein c-Rel plays a critical role in controlling autoimmunity. c-Rel-deficient mice are resistant to streptozotocin-induced diabetes, a drug-induced model of autoimmune diabetes. We generated c-Rel-deficient NOD mice to examine the role of c-Rel in the development of spontaneous autoimmune diabetes. We found that both CD4(+) and CD8(+) T cells from c-Rel-deficient NOD mice showed significantly decreased T-cell receptor-induced IL-2, IFN-γ, and GM-CSF expression. Despite compromised T-cell function, c-Rel deficiency dramatically accelerated insulitis and hyperglycemia in NOD mice along with a substantial reduction in T-regulatory (Treg) cell numbers. Supplementation of isogenic c-Rel-competent Treg cells from prediabetic NOD mice reversed the accelerated diabetes development in c-Rel-deficient NOD mice. The results suggest that c-Rel-dependent Treg cell function is critical in suppressing early-onset autoimmune diabetogenesis in NOD mice. This study provides a novel natural system to study autoimmune diabetes pathogenesis and reveals a previously unknown c-Rel-dependent mechanistic difference between chemically induced and spontaneous diabetogenesis. The study also reveals a unique protective role of c-Rel in autoimmune diabetes, which is distinct from other T-cell-dependent autoimmune diseases such as arthritis and experimental autoimmune encephalomyelitis, where c-Rel promotes autoimmunity. PMID:27217485

  12. Energy and water development appropriations for 1988. Hearings before a Subcommittee of the Committee on Appropriations, House of Representatives, One Hundredth Congress, First Session, Part 2

    SciTech Connect

    Not Available

    1987-01-01

    Part 2 of the hearing record covers testimony relating to appropriations for the Corps of Engineers, with separate sections on the North Pacific, North Central, North Atlantic, South Atlantic, New England, and Pacific Ocean divisions of the Corps and the Commissions for each of the Potomac, Delaware, and Susquehanna river basins. A list of witnesses appears at the beginning of each section. Descriptions of the various energy and water development programs and future plans, along with funding requirements, make up the testimony.

  13. Servant-Leader Development in an Adult Accelerated Degree Completion Program: A Mixed-Methods Study

    ERIC Educational Resources Information Center

    Anderson, Angela R.

    2009-01-01

    Although many private Christian liberal arts programs exist today that seek to foster servant-leader (SL) development within their students, there is a void of both literature and data that details how servant-leadership development occurs and what contexts may be appropriate or necessary for this development. The purpose of this study was to…

  14. An improved anti-leech mechanism based on session identifier

    NASA Astrophysics Data System (ADS)

    Zhang, Jianbiao; Zhu, Tong; Zhang, Han; Lin, Li

    2012-01-01

    With the rapid development of information technology and extensive requirement of network resource sharing, plenty of resource hotlinking phenomenons appear on the internet. The hotlinking problem not only harms the interests of legal websites but also leads to a great affection to fair internet environment. The anti-leech technique based on session identifier is highly secure, but the transmission of session identifier in plaintext form causes some security flaws. In this paper, a proxy hotlinking technique based on session identifier is introduced firstly to illustrate these security flaws; next, this paper proposes an improved anti-leech mechanism based on session identifier, the mechanism takes the random factor as the core and detects hotlinking request using a map table that contains random factor, user's information and time stamp; at last the paper analyzes the security of mechanism in theory. The result reveals that the improved mechanism has the merits of simple realization, high security and great flexibility.

  15. An improved anti-leech mechanism based on session identifier

    NASA Astrophysics Data System (ADS)

    Zhang, Jianbiao; Zhu, Tong; Zhang, Han; Lin, Li

    2011-12-01

    With the rapid development of information technology and extensive requirement of network resource sharing, plenty of resource hotlinking phenomenons appear on the internet. The hotlinking problem not only harms the interests of legal websites but also leads to a great affection to fair internet environment. The anti-leech technique based on session identifier is highly secure, but the transmission of session identifier in plaintext form causes some security flaws. In this paper, a proxy hotlinking technique based on session identifier is introduced firstly to illustrate these security flaws; next, this paper proposes an improved anti-leech mechanism based on session identifier, the mechanism takes the random factor as the core and detects hotlinking request using a map table that contains random factor, user's information and time stamp; at last the paper analyzes the security of mechanism in theory. The result reveals that the improved mechanism has the merits of simple realization, high security and great flexibility.

  16. Energy and water development appropriations for 1986. Part 2. Hearings before a Subcommittee of the Committee on Appropriations, House of Representatives, Ninety-Ninth Congress, First Session

    SciTech Connect

    Not Available

    1985-01-01

    Part 2 of the hearing record covers 1220 pages of testimony given by the Corps of Engineers on projects in the North Pacific, Lower Mississippi Valley, South Atlantic, South Pacific, and Pacific Ocean Divisions. It also includes reports from the Delaware River Basin and Susquehanna River Basin Commissions and the Potomac River Basin Interstate Commission. Six officials from the engineering, planning, construction-operations, and program development offices reported on work in progress and explained the budget requests in detail. The projects include river levees, flood control, irrigation, dams, and navigation. The record includes their testimony and supporting documentation.

  17. Accelerating the development of 21st-century toxicology: outcome of a Human Toxicology Project Consortium workshop.

    PubMed

    Stephens, Martin L; Barrow, Craig; Andersen, Melvin E; Boekelheide, Kim; Carmichael, Paul L; Holsapple, Michael P; Lafranconi, Mark

    2012-02-01

    The U.S. National Research Council (NRC) report on "Toxicity Testing in the 21st century" calls for a fundamental shift in the way that chemicals are tested for human health effects and evaluated in risk assessments. The new approach would move toward in vitro methods, typically using human cells in a high-throughput context. The in vitro methods would be designed to detect significant perturbations to "toxicity pathways," i.e., key biological pathways that, when sufficiently perturbed, lead to adverse health outcomes. To explore progress on the report's implementation, the Human Toxicology Project Consortium hosted a workshop on 9-10 November 2010 in Washington, DC. The Consortium is a coalition of several corporations, a research institute, and a non-governmental organization dedicated to accelerating the implementation of 21st-century Toxicology as aligned with the NRC vision. The goal of the workshop was to identify practical and scientific ways to accelerate implementation of the NRC vision. The workshop format consisted of plenary presentations, breakout group discussions, and concluding commentaries. The program faculty was drawn from industry, academia, government, and public interest organizations. Most presentations summarized ongoing efforts to modernize toxicology testing and approaches, each with some overlap with the NRC vision. In light of these efforts, the workshop identified recommendations for accelerating implementation of the NRC vision, including greater strategic coordination and planning across projects (facilitated by a steering group), the development of projects that test the proof of concept for implementation of the NRC vision, and greater outreach and communication across stakeholder communities. PMID:21948868

  18. Accelerating the Development of 21st-Century Toxicology: Outcome of a Human Toxicology Project Consortium Workshop

    PubMed Central

    Stephens, Martin L.; Barrow, Craig; Andersen, Melvin E.; Boekelheide, Kim; Carmichael, Paul L.; Holsapple, Michael P.; Lafranconi, Mark

    2012-01-01

    The U.S. National Research Council (NRC) report on “Toxicity Testing in the 21st century” calls for a fundamental shift in the way that chemicals are tested for human health effects and evaluated in risk assessments. The new approach would move toward in vitro methods, typically using human cells in a high-throughput context. The in vitro methods would be designed to detect significant perturbations to “toxicity pathways,” i.e., key biological pathways that, when sufficiently perturbed, lead to adverse health outcomes. To explore progress on the report’s implementation, the Human Toxicology Project Consortium hosted a workshop on 9–10 November 2010 in Washington, DC. The Consortium is a coalition of several corporations, a research institute, and a non-governmental organization dedicated to accelerating the implementation of 21st-century Toxicology as aligned with the NRC vision. The goal of the workshop was to identify practical and scientific ways to accelerate implementation of the NRC vision. The workshop format consisted of plenary presentations, breakout group discussions, and concluding commentaries. The program faculty was drawn from industry, academia, government, and public interest organizations. Most presentations summarized ongoing efforts to modernize toxicology testing and approaches, each with some overlap with the NRC vision. In light of these efforts, the workshop identified recommendations for accelerating implementation of the NRC vision, including greater strategic coordination and planning across projects (facilitated by a steering group), the development of projects that test the proof of concept for implementation of the NRC vision, and greater outreach and communication across stakeholder communities. PMID:21948868

  19. Laser-driven x-ray and neutron source development for industrial applications of plasma accelerators

    NASA Astrophysics Data System (ADS)

    Brenner, C. M.; Mirfayzi, S. R.; Rusby, D. R.; Armstrong, C.; Alejo, A.; Wilson, L. A.; Clarke, R.; Ahmed, H.; Butler, N. M. H.; Haddock, D.; Higginson, A.; McClymont, A.; Murphy, C.; Notley, M.; Oliver, P.; Allott, R.; Hernandez-Gomez, C.; Kar, S.; McKenna, P.; Neely, D.

    2016-01-01

    Pulsed beams of energetic x-rays and neutrons from intense laser interactions with solid foils are promising for applications where bright, small emission area sources, capable of multi-modal delivery are ideal. Possible end users of laser-driven multi-modal sources are those requiring advanced non-destructive inspection techniques in industry sectors of high value commerce such as aerospace, nuclear and advanced manufacturing. We report on experimental work that demonstrates multi-modal operation of high power laser-solid interactions for neutron and x-ray beam generation. Measurements and Monte Carlo radiation transport simulations show that neutron yield is increased by a factor ~2 when a 1 mm copper foil is placed behind a 2 mm lithium foil, compared to using a 2 cm block of lithium only. We explore x-ray generation with a 10 picosecond drive pulse in order to tailor the spectral content for radiography with medium density alloy metals. The impact of using  >1 ps pulse duration on laser-accelerated electron beam generation and transport is discussed alongside the optimisation of subsequent bremsstrahlung emission in thin, high atomic number target foils. X-ray spectra are deconvolved from spectrometer measurements and simulation data generated using the GEANT4 Monte Carlo code. We also demonstrate the unique capability of laser-driven x-rays in being able to deliver single pulse high spatial resolution projection imaging of thick metallic objects. Active detector radiographic imaging of industrially relevant sample objects with a 10 ps drive pulse is presented for the first time, demonstrating that features of 200 μm size are resolved when projected at high magnification.

  20. Development and Dosimetric Characterization of a Tissue Substitute (Bolus) For Use in Linear Accelerator Electron Radiotherapy

    NASA Astrophysics Data System (ADS)

    Estrada Trujillo, Jorge; Villaseñor Navarro, Luis Felipe; Mitsoura, Eleni

    2003-09-01

    We propose the design of a new custom made material, to be used as a tissue substitute in external beam electron radiotherapy, based on cotton fabric and beeswax. Due to its inexpensive, easy preparation, constant thickness, flexibility, uniform density and physical properties similar to those of soft tissue, this bolus will insure personalized optimal dose build up and dose distribution in irregular treatment regions. Materials and Methods: We used commercial Campeche beeswax and 100% cotton fabric to prepare the bolus. Beeswax's physical characteristics were determined by thermal and density analysis. Its chemical properties are to be determined by electronic microcopy. We performed quality control tests and calibration of the Varian 2100C linear accelerator. The tissue equivalence of the material is established for a range of electron energies (6, 9, 12, 16, 20 MeV) using a water equivalent solid phantom (PTW; Freiburg, Germany) and a plane parallel ionization chamber (PTW) associated to a PTW electrometer. Results: Beeswax's absolute density was found to be 0.9181g/ml at 21°C, with a melting point of 45°C. For the bolus elaboration, the cotton fabric was soaked in liquid beeswax and thin sheets of approximately 1 mm were obtained. These presented high flexibility, physical stability (color, texture, thickness) and homogeneity. Determination of this dosimetric characteristics and equivalent thickness are still in process. Discussion and conclusions: Our preliminary results suggest that the tissue substitute is easily made, inexpensive to produce, molds well to the treatment area and its positioning is easy and reproducible over the course of the treatment. So we consider that it's a good alternative to the commercial bolus.

  1. Session: Long Valley Exploratory Well

    SciTech Connect

    Tennyson, George P. Jr.; Finger, John T.; Eichelberger, John C.; Hickox, Charles E.

    1992-01-01

    This session at the Geothermal Energy Program Review X: Geothermal Energy and the Utility Market consisted of four presentations: ''Long Valley Exploratory Well - Summary'' by George P. Tennyson, Jr.; ''The Long Valley Well - Phase II Operations'' by John T. Finger; ''Geologic results from the Long Valley Exploratory Well'' by John C. Eichelberger; and ''A Model for Large-Scale Thermal Convection in the Long Valley Geothermal Region'' by Charles E. Hickox.

  2. Government-industry-uUniversity and rResearch lLaboratories cCoordination for new product development: Session 2. Government research laboratory perspective

    SciTech Connect

    Kuzay, T.M.

    1997-09-01

    This talk is the second in an expanded series of presentations on the Government-Industry-University and Research Laboratories Coordination for new product development, which is a timely and important public policy issue. Such interactions have become particularly timely in light of the present decline in funding for research and development (R&D) in the nation`s budget and in the private sector. These interactions, at least in principle, provide a means to maximize benefits for the greater good of the nation by pooling the diminishing resources. National laboratories, which traditionally interacted closely with the universities in educational training, now are able to also participate closely with industry in joint R&D thanks to a number of public laws legislated since the early 80s. A review of the experiences with such interactions at Argonne National Laboratory, which exemplifies the national laboratories, shows that, despite differences in their traditions and the missions, the national laboratory-industry-university triangle can work together.

  3. Development of Ta-matrix Nb3Al Strand and Cable for High-Field Accelerator Magnet

    SciTech Connect

    Tsuchiya, K.; Ghosh, A.; Kikuchi, A.; Takeuchi, T.; Banno, N.; Iijima, Y.; Nimori, S.; Takigawa, H.; Terashima, A.; Nakamoto, T.; Kuroda, Y.; Maruyama, M.; Takao, T.; Tanaka, K.; Nakagawa, K.; Barzi, E.; Yamada, R.; Zlobin, A.

    2011-08-03

    Research and development of Nb{sub 3}Al strands and cables for a high field accelerator magnet is ongoing under the framework of the CERN-KEK collaboration. In this program, new Ta-matrix Nb{sub 3}Al strands were developed and their mechanical properties and superconducting properties were studied. The non-Cu J{sub c} values of these strands were 750 {approx} 800 A/mm{sup 2} at 15 T and 4.2 K. Using these strands, test fabrication of 27-strand Rutherford cable was carried out in collaboration with NIMS and Fermilab. The properties of the strands extracted from the cable were examined and it was found that there was no degradation of the superconducting properties of the strands. In this paper, we report the fabrication of the strands and the cable in brief and present some of the results obtained by studying their properties.

  4. DevLore - A Firmware Library and Web-Based Configuration Control Tool for Accelerator Systems Under Constant Development

    SciTech Connect

    Richard Evans; Kevin Jordan; Deborah Gruber; Daniel Sexton

    2005-10-10

    The Free Electron Laser Project at Jefferson Lab is based on a comparatively small accelerator driver. As it's systems continues to grow and evolve, strict configuration control has not been a programmatic goal. Conversely, as the IR-Demo FEL and the 10kW IR FEL have been built and operated, hardware and software changes have been regular part of the machine development process. With relatively small component counts for sub-systems, changes occur without requiring much formal documentation and in-situ alterations are common-place in the name of supporting operations. This paper presents an overview of the web-based software tool called DevLore which was first developed to be a library for embedded programming and then became a tremendously effective tool for tracking all changes made to the machine hardware and software.

  5. Development of the integrated control system for the microwave ion source of the PEFP 100-MeV proton accelerator

    NASA Astrophysics Data System (ADS)

    Song, Young-Gi; Seol, Kyung-Tae; Jang, Ji-Ho; Kwon, Hyeok-Jung; Cho, Yong-Sub

    2012-07-01

    The Proton Engineering Frontier Project (PEFP) 20-MeV proton linear accelerator is currently operating at the Korea Atomic Energy Research Institute (KAERI). The ion source of the 100-MeV proton linac needs at least a 100-hour operation time. To meet the goal, we have developed a microwave ion source that uses no filament. For the ion source, a remote control system has been developed by using experimental physics and the industrial control system (EPICS) software framework. The control system consists of a versa module europa (VME) and EPICS-based embedded applications running on a VxWorks real-time operating system. The main purpose of the control system is to control and monitor the operational variables of the components remotely and to protect operators from radiation exposure and the components from critical problems during beam extraction. We successfully performed the operation test of the control system to confirm the degree of safety during the hardware performance.

  6. Component Development to Accelerate Commercial Implementation of Ultra-Low Emissions Catalytic Combustion

    SciTech Connect

    McCarty, Jon; Berry, Brian; Lundberg, Kare; Anson, Orris

    2003-03-31

    This final report describes a 2000-2003 program for the development of components and processes to enhance the commercialization of ultra-low emissions catalytic combustion in industrial gas turbines. The range of project tasks includes: development of more durable, lower-cost catalysts and catalytic combustor components; development and design of a catalytic pre-burner and a catalytic pilot burner for gas turbines, and on-site fuel conversion processing for utilization of liquid fuel.

  7. Accelerating the Achievement of the Millennium Development Goals in Ghana: Literacy, the Missing Link

    ERIC Educational Resources Information Center

    Tagoe, Michael Ayitey

    2011-01-01

    The Millennium Development Goals launched in 2001 provide a worldwide agenda to reduce poverty by 2015. Though the eight goals provide synergies for the rapid reduction of poverty, the MDGs have come under criticism for being too narrow and sometimes leaving out critical aspects of human development and well-being. Although the MDGs address some…

  8. Development of dual-beam system using an electrostatic accelerator for in-situ observation of swift heavy ion irradiation effects on materials

    NASA Astrophysics Data System (ADS)

    Matsuda, M.; Asozu, T.; Sataka, M.; Iwase, A.

    2013-11-01

    We have developed the dual beam system which accelerates two kinds of ion beams simultaneously especially for real-time ion beam analysis. We have also developed the alternating beam system which can efficiently change beam species in a short time in order to realize efficient ion beam analysis in a limited beam time. The acceleration of the dual beam is performed by the 20 UR Pelletron™ tandem accelerator in which an ECR ion source is mounted at the high voltage terminal [1,2]. The multi-charged ions of two or more elements can be simultaneously generated from the ECR ion source, so dual-beam irradiation is achieved by accelerating ions with the same charge to mass ratio (for example, 132Xe11+ and 12C+). It enables us to make a real-time beam analysis such as Rutherford Back Scattering (RBS) method, while a target is irradiated with swift heavy ions. For the quick change of the accelerating ion beam, the program of automatic setting of the optical parameter of the accelerator has been developed. The switchover time for changing the ion beam is about 5 min. These developments have been applied to the study on the ion beam mixing caused by high-density electronic excitation induced by swift heavy ions.

  9. Development of an ultrasmall C-band linear accelerator guide for a four-dimensional image-guided radiotherapy system with a gimbaled x-ray head

    SciTech Connect

    Kamino, Yuichiro; Miura, Sadao; Kokubo, Masaki; Yamashita, Ichiro; Hirai, Etsuro; Hiraoka, Masahiro; Ishikawa, Junzo

    2007-05-15

    We are developing a four-dimensional image-guided radiotherapy system with a gimbaled x-ray head. It is capable of pursuing irradiation and delivering irradiation precisely with the help of an agile moving x-ray head on the gimbals. Requirements for the accelerator guide were established, system design was developed, and detailed design was conducted. An accelerator guide was manufactured and basic beam performance and leakage radiation from the accelerator guide were evaluated at a low pulse repetition rate. The accelerator guide including the electron gun is 38 cm long and weighs about 10 kg. The length of the accelerating structure is 24.4 cm. The accelerating structure is a standing wave type and is composed of the axial-coupled injector section and the side-coupled acceleration cavity section. The injector section is composed of one prebuncher cavity, one buncher cavity, one side-coupled half cavity, and two axial coupling cavities. The acceleration cavity section is composed of eight side-coupled nose reentrant cavities and eight coupling cavities. The electron gun is a diode-type gun with a cerium hexaboride (CeB{sub 6}) direct heating cathode. The accelerator guide can be operated without any magnetic focusing device. Output beam current was 75 mA with a transmission efficiency of 58%, and the average energy was 5.24 MeV. Beam energy was distributed from 4.95 to 5.6 MeV. The beam profile, measured 88 mm from the beam output hole on the axis of the accelerator guide, was 0.7 mmx0.9 mm full width at half maximum (FWHM) width. The beam loading line was 5.925 (MeV)-I{sub b} (mA)x0.00808 (MeV/mA), where I{sub b} is output beam current. The maximum radiation leakage of the accelerator guide at 100 cm from the axis of the accelerator guide was calculated as 0.33 cGy/min at the rated x-ray output of 500 cGy/min from the measured value. This leakage requires no radiation shielding for the accelerator guide itself per IEC 60601-2-1.

  10. Development of an ultrasmall C-band linear accelerator guide for a four-dimensional image-guided radiotherapy system with a gimbaled x-ray head.

    PubMed

    Kamino, Yuichiro; Miura, Sadao; Kokubo, Masaki; Yamashita, Ichiro; Hirai, Etsuro; Hiraoka, Masahiro; Ishikawa, Junzo

    2007-05-01

    We are developing a four-dimensional image-guided radiotherapy system with a gimbaled x-ray head. It is capable of pursuing irradiation and delivering irradiation precisely with the help of an agile moving x-ray head on the gimbals. Requirements for the accelerator guide were established, system design was developed, and detailed design was conducted. An accelerator guide was manufactured and basic beam performance and leakage radiation from the accelerator guide were evaluated at a low pulse repetition rate. The accelerator guide including the electron gun is 38 cm long and weighs about 10 kg. The length of the accelerating structure is 24.4 cm. The accelerating structure is a standing wave type and is composed of the axial-coupled injector section and the side-coupled acceleration cavity section. The injector section is composed of one prebuncher cavity, one buncher cavity, one side-coupled half cavity, and two axial coupling cavities. The acceleration cavity section is composed of eight side-coupled nose reentrant cavities and eight coupling cavities. The electron gun is a diode-type gun with a cerium hexaboride (CeB6) direct heating cathode. The accelerator guide can be operated without any magnetic focusing device. Output beam current was 75 mA with a transmission efficiency of 58%, and the average energy was 5.24 MeV. Beam energy was distributed from 4.95 to 5.6 MeV. The beam profile, measured 88 mm from the beam output hole on the axis of the accelerator guide, was 0.7 mm X 0.9 mm full width at half maximum (FWHM) width. The beam loading line was 5.925 (MeV)-Ib (mA) X 0.00808 (MeV/mA), where Ib is output beam current. The maximum radiation leakage of the accelerator guide at 100 cm from the axis of the accelerator guide was calculated as 0.33 cGy/min at the rated x-ray output of 500 cGy/min from the measured value. This leakage requires no radiation shielding for the accelerator guide itself per IEC 60601-2-1. PMID:17555261

  11. Search for major genes with progeny test data to accelerate the development of genetically superior loblolly pine

    SciTech Connect

    NCSU

    2003-12-30

    This research project is to develop a novel approach that fully utilized the current breeding materials and genetic test information available from the NCSU-Industry Cooperative Tree Improvement Program to identify major genes that are segregating for growth and disease resistance in loblolly pine. If major genes can be identified in the existing breeding population, they can be utilized directly in the conventional loblolly pine breeding program. With the putative genotypes of parents identified, tree breeders can make effective decisions on management of breeding populations and operational deployment of genetically superior trees. Forest productivity will be significantly enhanced if genetically superior genotypes with major genes for economically important traits could be deployed in an operational plantation program. The overall objective of the project is to develop genetic model and analytical methods for major gene detection with progeny test data and accelerate the development of genetically superior loblolly pine. Specifically, there are three main tasks: (1) Develop genetic models for major gene detection and implement statistical methods and develop computer software for screening progeny test data; (2) Confirm major gene segregation with molecular markers; and (3) Develop strategies for using major genes for tree breeding.

  12. Accelerated Geothermal Resource Development in the Great Basin Through Enhanced Public Awareness and Outreach to Shareholders.

    SciTech Connect

    Taranik, James V.; Oppliger, Gary; Sawatsky, Don

    2002-04-10

    The Great Basin Center for Geothermal Energy conducted work encompassing two main tasks. We (1) produced a web-based, stakeholder geothermal information system for Nevada geothermal data relevant to assessing and developing geothermal resources, and (2) we held informational stakeholder workshops (both as part of GeoPowering the West Initiative). The objective of this grant was to conduct workshops and fund database and web development activities. This grant funds salaries for web and database developers and part of the administrative assistant who helps to coordinate and organize workshops, and maintain selected databases.

  13. Plasma accelerators

    SciTech Connect

    Ruth, R.D.; Chen, P.

    1986-03-01

    In this paper we discuss plasma accelerators which might provide high gradient accelerating fields suitable for TeV linear colliders. In particular we discuss two types of plasma accelerators which have been proposed, the Plasma Beat Wave Accelerator and the Plasma Wake Field Accelerator. We show that the electric fields in the plasma for both schemes are very similar, and thus the dynamics of the driven beams are very similar. The differences appear in the parameters associated with the driving beams. In particular to obtain a given accelerating gradient, the Plasma Wake Field Accelerator has a higher efficiency and a lower total energy for the driving beam. Finally, we show for the Plasma Wake Field Accelerator that one can accelerate high quality low emittance beams and, in principle, obtain efficiencies and energy spreads comparable to those obtained with conventional techniques.

  14. Summer Session Organizational Models at Canadian Universities

    ERIC Educational Resources Information Center

    Kops, Bill

    2010-01-01

    The issue of summer session organizational models continues to be of interest to summer session deans/directors and university administrators. The University of Victoria surveyed Canadian universities on this issue in 1994. Based on a similar survey done in 2009, this paper updates the status of Canadian university summer session organizational…

  15. Communicating Earth Science Applications through Virtual Poster Sessions

    NASA Astrophysics Data System (ADS)

    Favors, J. E.; Childs-Gleason, L. M.; Ross, K. W.; Ruiz, M. L.; Rogers, L.

    2013-12-01

    The DEVELOP National Program addresses environmental and public policy issues through interdisciplinary research projects that apply the lens of NASA Earth observations to community concerns around the globe. Part of NASA's Applied Sciences' Capacity Building Program, DEVELOP bridges the gap between NASA Earth Science and society, building capacity in both participants and partner organizations to better prepare them to handle the challenges that face our society and future generations. Teams of DEVELOP participants partner with decision makers to conduct rapid feasibility projects that highlight fresh applications of NASA's suite of Earth observing sensors, cultivate advanced skills, and increase understanding of NASA Earth Science data and technology. Part of this process involves the creation of short introductory videos that demonstrate the environmental concerns, project methodologies and results, and an overview of how this work will impact decision makers. These videos are presented to the public three times a year in 'virtual poster sessions' (VPS) that provide an interactive way for individuals from around the globe to access the research, understand the capabilities and applications of NASA's Earth science datasets, and interact with the participants through blogging and dialogue sessions. Virtual poster sessions have allowed DEVELOP to introduce NASA's Earth science assets to thousands of viewers around the world. For instance, one fall VPS had over 5,000 visitors from 89 different countries during the two week session. This presentation will discuss lessons learned and statistics related to the series of nine virtual poster sessions that DEVELOP has conducted 2011-2013.

  16. Plasma-based accelerator structures

    SciTech Connect

    Schroeder, Carl B.

    1999-12-01

    Plasma-based accelerators have the ability to sustain extremely large accelerating gradients, with possible high-energy physics applications. This dissertation further develops the theory of plasma-based accelerators by addressing three topics: the performance of a hollow plasma channel as an accelerating structure, the generation of ultrashort electron bunches, and the propagation of laser pulses is underdense plasmas.

  17. 78 FR 45494 - Plant Breeding Listening Session meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-29

    ... breeding and cultivar development stakeholders. DATES: The Plant Breeding Listening Session will be held... discuss their plant breeding and cultivar development programs and/or their perception of needs and potential improvements in publicly-funded plant breeding and cultivar development research. Following...

  18. The Application of Computer Technology for Development.

    ERIC Educational Resources Information Center

    United Nations, New York, NY. Dept. of Economic and Social Affairs.

    At its twenty-third session, the General Assembly adopted resolution 2458(XXII) requesting the Secretary-General to prepare a report giving special consideration to the situation of the developing countries with regard to: (1) the results already obtained and the needs and prospects for the use of electronic computers in accelerating the process…

  19. Accelerated Capacity Development in Water Resources Education: the experiences of the Ethiopian Institute of Water Resources

    NASA Astrophysics Data System (ADS)

    Alamirew, T.; Mekonnen, G.; Viglione, A.

    2012-04-01

    Ethiopia recently recognises that the water resources development is the major entry point in poverty alleviation and sustainable development. Water in Ethiopia plays a key role in the Water-Energy-Food-nexus. Over 98% of the electricity in the country is generated using hydropower and yet about 2000 MW has been developed. Out of the 3.5 Mha potentially irrigable land, only 0.25 Mha has been developed to date. Access to drinking water supply coverage is among the lowest in the world. One of the limiting factors in harnessing the resource base is the absence of water professionals to face the fast growing demand in education, research, development in the water sector. Recognising this, in collaboration with University of Connecticut of the United States, Addis Ababa University launched the Ethiopian Institute of Water Resources (EIWR) by enrolling 18 PhD and 24 MSc students. The program is unique in that much of the course instructors are coming from US and European Universities, but deliver courses together with Ethiopian collaborators. This is supposed to facilitate knowledge and experience transfer from the US/EU scientist to Ethiopian counterparts. The theses/dissertations are designed to focus on Ethiopia's immediate hydrological problems on selected basins, and will be coordinated by three advisors for each PhD - one from US/EU, one from Ethiopian Universities, and one water professional from the sector. We report here the lessons learned in setting up the EIWR institute and the education program.

  20. Accelerated process development for protease production in continuous multi-stage cultures.

    PubMed

    Raninger, A; Steiner, W

    2003-06-01

    A fermentation process was developed and optimized for the production of a specific protease from Bacillus licheniformis PWD-1. Media formulations were constructed and crucial environmental parameters were optimized to enhance growth and product formation. Process dynamics of substrate consumption, biomass-, product-, as well as by-product formation were determined under controlled conditions in a bioreactor. Using kinetic data from batch- and continuous-culture experiments, a fed-batch process was developed producing proteolytic activities 10 times those found during regular batch culture. In one stage continuous stirred tank culture protease formation was completely decoupled from sporulation. Shift experiments in one-stage continuous cultures led to the development of a two-stage continuous stirred tank fermentation process using optimized conditions for growth in the first stage and protease formation in the second stage. Accordingly, the basis for a continuous production of the enzyme on a pilot scale was accomplished. PMID:12652475

  1. Accelerated technology development by the use of critical point imaging SEM

    NASA Astrophysics Data System (ADS)

    Sanchez, Dominique; Hinschberger, Benôit; Bouckou, Loemba; Moreau, Olivier; Parisi, Paolo

    2015-03-01

    In order to optimize the time to market of the newest technology nodes and maximize their profitability, advanced semiconductor manufacturers need to adapt their yield enhancement strategies to their current development stage. During very early development, gross Defectivity at some critical process steps often makes it impractical to use broadband plasma or laser scanning micro-defect patterned wafer inspection techniques: such sensitive defect inspections capture a large number of defects, producing wafer defect maps so heavily populated that even wafer level signature are difficult to visualize.

  2. Development of a cryogenic load frame for the neutron diffractometer at Takumi in Japan Proton Accelerator Research Complex

    SciTech Connect

    Jin, Xinzhe; Nakamoto, Tatsushi; Ogitsu, Toru; Yamamoto, Akira; Sugano, Michinaka; Harjo, Stefanus; Aizawa, Kazuya; Abe, Jun; Gong, Wu; Iwahashi, Takaaki; Hemmi, Tsutomu; Umeno, Takahiro

    2013-06-15

    To prepare for projects such as the Large Hadron Collider upgrade, International Thermonuclear Experimental Reactor and Demonstration reactor, it is important to form a clear understanding of stress-strain properties of the materials that make up superconducting magnets. Thus, we have been studying the mechanical properties of superconducting wires using neutron diffraction measurements. To simulate operational conditions such as temperature, stress, and strain, we developed a cryogenic load frame for stress-strain measurements of materials using a neutron diffractometer at Japan Proton Accelerator Research Complex (J-PARC) Takumi beam line. The maximum load that can be applied to a sample using an external driving machine is 50 kN. Using a Gifford-MacMahon cryocooler, samples can be measured down to temperatures below 10 K when loaded. In the present paper, we describe the details of the cryogenic load frame with its test results by using type-304 stainless steel wire.

  3. Development of a cryogenic load frame for the neutron diffractometer at Takumi in Japan Proton Accelerator Research Complex.

    PubMed

    Jin, Xinzhe; Nakamoto, Tatsushi; Harjo, Stefanus; Hemmi, Tsutomu; Umeno, Takahiro; Ogitsu, Toru; Yamamoto, Akira; Sugano, Michinaka; Aizawa, Kazuya; Abe, Jun; Gong, Wu; Iwahashi, Takaaki

    2013-06-01

    To prepare for projects such as the Large Hadron Collider upgrade, International Thermonuclear Experimental Reactor and Demonstration reactor, it is important to form a clear understanding of stress-strain properties of the materials that make up superconducting magnets. Thus, we have been studying the mechanical properties of superconducting wires using neutron diffraction measurements. To simulate operational conditions such as temperature, stress, and strain, we developed a cryogenic load frame for stress-strain measurements of materials using a neutron diffractometer at Japan Proton Accelerator Research Complex (J-PARC) Takumi beam line. The maximum load that can be applied to a sample using an external driving machine is 50 kN. Using a Gifford-MacMahon cryocooler, samples can be measured down to temperatures below 10 K when loaded. In the present paper, we describe the details of the cryogenic load frame with its test results by using type-304 stainless steel wire. PMID:23822332

  4. Basic Electropolishing Process Research and Development in Support of Improved Reliable Performance SRF Cavities for the Future Accelerator

    SciTech Connect

    H. Tian, C.E. Reece,M.J. Kelley

    2009-05-01

    Future accelerators require unprecedented cavity performance, which is strongly influenced by interior surface nanosmoothness. Electropolishing is the technique of choice to be developed for high-field superconducting radiofrequency cavities. Electrochemical impedance spectroscopy (EIS) and related techniques point to the electropolishing mechanism of Nb in a sulfuric and hydrofluoric acid electrolyte of controlled by a compact surface salt film under F- diffusion-limited mass transport control. These and other findings are currently guiding a systematic characterization to form the basis for cavity process optimization, such as flowrate, electrolyte composition and temperature. This integrated analysis is expected to provide optimum EP parameter sets for a controlled, reproducible and uniform surface leveling for Nb SRF cavities.

  5. Recent developments of the ion sources at Tri University Meson Factory/Isotope Separator and ACcelerator Facility

    SciTech Connect

    Bricault, P. G.; Ames, F.; Dombsky, M.; Labrecque, F.; Lassen, J.; Mjos, A.; Minor, G.; Tigelhoefer, A.

    2012-02-15

    This paper describes the recent progresses concerning the on-line ion source at the Tri University Meson Factory/Isotope Separator and ACcelerator (TRIUMF/ISAC) Radioactive Ion-Beam Facility; description of the new design of the surface-ion-source for improved stability of the beam intensity, description of the transport path to the east target station at ISAC, description of the new brazing techniques that solved recurrent problems with water leaks on the target/ion source assembly in the vacuum system, finally, recent developments concerning the Forced Electron Beam Induced Arc Discharge (FEBIAD) ion source are reported. In particular, a study on the effect of the plasma chamber volume on the ionization efficiency was completed.

  6. Development of an Accelerated Test Design for Predicting the Service Life of the Solar Array at Mead, Nebraska

    NASA Technical Reports Server (NTRS)

    Gaines, G. B.; Thomas, R. E.; Noel, G. T.; Shilliday, T. S.; Wood, V. E.; Carmichael, D. C.

    1979-01-01

    Potential long-term degradation modes for the two types of modules in the Mead array were determined and judgments were made as to those environmental stresses and combinations of stresses which accelerate the degradation of the power output. Hierarchical trees representing the severity of effects of stresses (test conditions) on eleven individual degradation modes were constructed and were pruned of tests judged to be nonessential. Composites of those trees were developed so that there is now one pruned tree covering eight degradation modes, another covering two degradation modes, and a third covering one degradation mode. These three composite trees form the basis for selection of test conditions in the final test plan which is now being prepared.

  7. Research proposal for development of an electron stripper using a thin liquid lithium film for rare isotope accelerator.

    SciTech Connect

    Momozaki, Y.; Nuclear Engineering Division

    2006-03-06

    Hydrodynamic instability phenomena in a thin liquid lithium film, which has been proposed for the first stripper in the driver linac of Rare Isotope Accelerator (RIA), were discussed. Since it was considered that film instability could significantly impair the feasibility of the liquid lithium film stripper concept, potential issues and research tasks in the RIA project due to these instability phenomena were raised. In order to investigate these instability phenomena, a research proposal plan was developed. In the theoretical part of this research proposal, a use of the linear stability theory was suggested. In the experimental part, it was pointed out that the concept of Reynolds number and Weber number scaling may allow conducting a preliminary experiment using inert simulants, hence reducing technical difficulty, complexity, and cost of the experiments. After confirming the thin film formation in the preliminary experiment using simulants, demonstration experiments using liquid lithium were proposed.

  8. Chronic exogenous kisspeptin administration accelerates gonadal development in basses of the genus Morone

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The present study assesses the effects of chronic administration of peptides to fish, termed kisspeptins, which are the products of the KISS1 and KISS2 genes, and have been shown to control the development of puberty in animals. Using ecologically and commercially important species (white bass, Mor...

  9. NREL Develops Accelerated Sample Activation Process for Hydrogen Storage Materials (Fact Sheet)

    SciTech Connect

    Not Available

    2010-12-01

    This fact sheet describes NREL's accomplishments in developing a new sample activation process that reduces the time to prepare samples for measurement of hydrogen storage from several days to five minutes and provides more uniform samples. Work was performed by NREL's Chemical and Materials Science Center.

  10. Administration of kisspeptins accelerates gonadal development and alters gene expression in Moronids

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The present study assesses the effects of chronic administration of peptides to fish, termed kisspeptins, which are the products of the KISS1 and KISS2 genes, and have been shown to control the development of puberty in animals. In aquaculture, one of the major obstacles to the commercial production...

  11. Scenarios for acceleration in fish development and the role of metamorphosis

    NASA Astrophysics Data System (ADS)

    Kooijman, S. A. L. M.; Pecquerie, L.; Augustine, S.; Jusup, M.

    2011-11-01

    We compare various alternative explanations of why embryo development is sometimes slow relative to juvenile and adult development on the basis of the standard Dynamic Energy Budget (DEB) model and make the comparison with avian altricial versus precocial development. We discuss the role of the energy investment ratio, which combines four different aspects of DEBs: allocation, assimilation, mobilisation and costs for structure. We show how this ratio affects the morphology of growth curves: the ratio of the slopes at start and birth during embryonic growth, as well as the von Bertalanffy time as function of ultimate length during post-embryonic growth. We propose an extension of the standard DEB model that combines a Gompertz (i.e. exponential) start with a von Bertalanffy 'tail' with a smooth transition; a combination that has been applied frequently in fisheries research and here given a mechanistic significance. Implications are that a slow embryonic development is combined with a fast post-metamorphic one and that parameters at metamorphosis depend on feeding history prior to metamorphosis. Identical individuals, in terms of parameter values and amounts of reserve and structure, will become permanently different when they experience different (local) environments, even if they experience identical environments after metamorphosis. This might explain part of the parameter variation amongst individuals.

  12. Meeting Emergent Needs in Uganda: A Path to Accelerated Development of Community and Work Colleges

    ERIC Educational Resources Information Center

    Cutright, Marc

    2014-01-01

    National development conditions and goals in Uganda, as in many nations, are such that the robust establishment of community colleges could provide many solutions. Yet the creation of such has been inhibited by a number of factors including the historic roots of higher education in former colonial contexts and a lack of Ugandan familiarity with…

  13. Accelerating the development of a therapeutic vaccine for human Chagas disease: rationale and prospects

    PubMed Central

    Zhan, Bin; Heffernan, Michael J; Jones, Kathryn; Valenzuela, Jesus G; Kamhawi, Shaden; Ortega, Jaime; de Leon Rosales, Samuel Ponce; Lee, Bruce Y; Bacon, Kristina M; Fleischer, Bernhard; Slingsby, BT; Cravioto, Miguel Betancourt; Tapia-Conyer, Roberto

    2013-01-01

    Chagas disease is a leading cause of heart disease affecting approximately 10 million people in Latin America and elsewhere worldwide. The two major drugs available for the treatment of Chagas disease have limited efficacy in Trypanosoma cruzi-infected adults with indeterminate (patients who have seroconverted but do not yet show signs or symptoms) and determinate (patients who have both seroconverted and have clinical disease) status; they require prolonged treatment courses and are poorly tolerated and expensive. As an alternative to chemotherapy, an injectable therapeutic Chagas disease vaccine is under development to prevent or delay Chagasic cardiomyopathy in patients with indeterminate or determinate status. The bivalent vaccine will be comprised of two recombinant T. cruzi antigens, Tc24 and TSA-1, formulated on alum together with the Toll-like receptor 4 agonist, E6020. Proof-of-concept for the efficacy of these antigens was obtained in preclinical testing at the Autonomous University of Yucatan. Here the authors discuss the potential for a therapeutic Chagas vaccine as well as the progress made towards such a vaccine, and the authors articulate a roadmap for the development of the vaccine as planned by the nonprofit Sabin Vaccine Institute Product Development Partnership and Texas Children’s Hospital Center for Vaccine Development in collaboration with an international consortium of academic and industrial partners in Mexico, Germany, Japan, and the USA. PMID:23151163

  14. Interactions of time of day and sleep with between-session habituation and extinction memory in young adult males

    PubMed Central

    Pace-Schott, Edward F.; Tracy, Lauren E.; Rubin, Zoe; Mollica, Adrian G.; Ellenbogen, Jeffrey M.; Bianchi, Matt T.; Milad, Mohammed R.; Pitman, Roger K.; Orr, Scott P.

    2014-01-01

    Within-session habituation and extinction learning co-occur as do subsequent consolidation of habituation (i.e., between-session habituation) and extinction memory. We sought to determine if, as we predicted: (1) between-session habituation is greater across a night of sleep vs. a day awake; (2) time-of-day accounts for differences; (3) between-session habituation predicts consolidation of extinction memory; (4) sleep predicts between-session habituation and/or extinction memory. Participants (N=28) completed 4–5 sessions alternating between mornings and evenings over 3 successive days (2 nights) with session 1 in either the morning (N=13) or evening (N=15). Twelve participants underwent laboratory polysomnography. During 4 sessions, participants completed a loud-tone habituation protocol while skin-conductance response (SCR), blink-startle electromyography (EMG), heart-rate acceleration (HRA) and deceleration (HRD) were recorded. For sessions 1 and 2, between-session habituation of EMG, SCR and HRD was greater across sleep. SCR and HRD were generally lower in the morning. Between-session habituation of SCR for sessions 1 and 2 was positively related to intervening (first night) slow wave sleep. In the evening before night 2, participants also underwent fear conditioning and extinction learning phases of a second protocol. Extinction recall was tested the following morning. Extinction recall was predicted only by between-session habituation of SCR across the same night (second night) and by intervening REM. We conclude that: 1) sleep augments between-session habituation, as does morning testing; 2) extinction recall is predicted by concurrent between-session habituation; and 3) both phenomena may be influenced by sleep. PMID:24481663

  15. Interactions of time of day and sleep with between-session habituation and extinction memory in young adult males.

    PubMed

    Pace-Schott, Edward F; Tracy, Lauren E; Rubin, Zoe; Mollica, Adrian G; Ellenbogen, Jeffrey M; Bianchi, Matt T; Milad, Mohammed R; Pitman, Roger K; Orr, Scott P

    2014-05-01

    Within-session habituation and extinction learning co-occur as do subsequent consolidation of habituation (i.e., between-session habituation) and extinction memory. We sought to determine whether, as we predicted: (1) between-session habituation is greater across a night of sleep versus a day awake; (2) time-of-day accounts for differences; (3) between-session habituation predicts consolidation of extinction memory; (4) sleep predicts between-session habituation and/or extinction memory. Participants (N = 28) completed 4-5 sessions alternating between mornings and evenings over 3 successive days (2 nights) with session 1 in either the morning (N = 13) or evening (N = 15). Twelve participants underwent laboratory polysomnography. During 4 sessions, participants completed a loud-tone habituation protocol, while skin conductance response (SCR), blink startle electromyography (EMG), heart-rate acceleration and heart-rate deceleration (HRD) were recorded. For sessions 1 and 2, between-session habituation of EMG, SCR and HRD was greater across sleep. SCR and HRD were generally lower in the morning. Between-session habituation of SCR for sessions 1 and 2 was positively related to intervening (first night) slow wave sleep. In the evening before night 2, participants also underwent fear conditioning and extinction learning phases of a second protocol. Extinction recall was tested the following morning. Extinction recall was predicted only by between-session habituation of SCR across the same night (second night) and by intervening REM. We conclude that: (1) sleep augments between-session habituation, as does morning testing; (2) extinction recall is predicted by concurrent between-session habituation; and (3) both phenomena may be influenced by sleep. PMID:24481663

  16. Theoretical Investigations of Plasma-Based Accelerators and Other Advanced Accelerator Concepts

    SciTech Connect

    Shuets, G.

    2004-05-21

    Theoretical investigations of plasma-based accelerators and other advanced accelerator concepts. The focus of the work was on the development of plasma based and structure based accelerating concepts, including laser-plasma, plasma channel, and microwave driven plasma accelerators.

  17. Accelerator-based BNCT.

    PubMed

    Kreiner, A J; Baldo, M; Bergueiro, J R; Cartelli, D; Castell, W; Thatar Vento, V; Gomez Asoia, J; Mercuri, D; Padulo, J; Suarez Sandin, J C; Erhardt, J; Kesque, J M; Valda, A A; Debray, M E; Somacal, H R; Igarzabal, M; Minsky, D M; Herrera, M S; Capoulat, M E; Gonzalez, S J; del Grosso, M F; Gagetti, L; Suarez Anzorena, M; Gun, M; Carranza, O

    2014-06-01

    The activity in accelerator development for accelerator-based BNCT (AB-BNCT) both worldwide and in Argentina is described. Projects in Russia, UK, Italy, Japan, Israel, and Argentina to develop AB-BNCT around different types of accelerators are briefly presented. In particular, the present status and recent progress of the Argentine project will be reviewed. The topics will cover: intense ion sources, accelerator tubes, transport of intense beams, beam diagnostics, the (9)Be(d,n) reaction as a possible neutron source, Beam Shaping Assemblies (BSA), a treatment room, and treatment planning in realistic cases. PMID:24365468

  18. Institutional computing (IC) information session

    SciTech Connect

    Koch, Kenneth R; Lally, Bryan R

    2011-01-19

    The LANL Institutional Computing Program (IC) will host an information session about the current state of unclassified Institutional Computing at Los Alamos, exciting plans for the future, and the current call for proposals for science and engineering projects requiring computing. Program representatives will give short presentations and field questions about the call for proposals and future planned machines, and discuss technical support available to existing and future projects. Los Alamos has started making a serious institutional investment in open computing available to our science projects, and that investment is expected to increase even more.

  19. Practical Session: Simple Linear Regression

    NASA Astrophysics Data System (ADS)

    Clausel, M.; Grégoire, G.

    2014-12-01

    Two exercises are proposed to illustrate the simple linear regression. The first one is based on the famous Galton's data set on heredity. We use the lm R command and get coefficients estimates, standard error of the error, R2, residuals …In the second example, devoted to data related to the vapor tension of mercury, we fit a simple linear regression, predict values, and anticipate on multiple linear regression. This pratical session is an excerpt from practical exercises proposed by A. Dalalyan at EPNC (see Exercises 1 and 2 of http://certis.enpc.fr/~dalalyan/Download/TP_ENPC_4.pdf).

  20. Working session 3: Tubing integrity

    SciTech Connect

    Cueto-Felgueroso, C.; Strosnider, J.

    1997-02-01

    Twenty-three individuals representing nine countries (Belgium, Canada, the Czech Republic, France, Japan, the Slovak Republic, Spain, the UK, and the US) participated in the session on tube integrity. These individuals represented utilities, vendors, consultants and regulatory authorities. The major subjects discussed by the group included overall objectives of managing steam generator tube degradation, necessary elements of a steam generator degradation management program, the concept of degradation specific management, structural integrity evaluations, leakage evaluations, and specific degradation mechanisms. The group`s discussions on these subjects, including conclusions and recommendations, are summarized in this article.

  1. Repurposing pharma assets: an accelerated mechanism for strengthening the schistosomiasis drug development pipeline.

    PubMed

    Ramamoorthi, Roopa; Graef, Katy M; Dent, Jennifer

    2015-01-01

    Schistosomiasis, one of 17 diseases deemed to be neglected by the World Health Organization, has received little attention from the biopharmaceutical industry. Due to this, only a handful of drugs have been developed to treat schistosomiasis, with only one, praziquantel, used in most endemic regions. Growing concern over resistance coupled with praziquantel's incomplete efficacy across all stages of the Schistosoma platyhelminth life cycle highlights the urgent need for new drugs. The WIPO Re:Search consortium is a platform whereupon biopharmaceutical company compounds are being repurposed to efficiently and cost-effectively develop new drugs for neglected diseases such as schistosomiasis. This article summarizes recent clinical-stage efforts to identify new antischistosomals and highlights biopharmaceutical company compounds with potential for repurposing to treat schistosomiasis. PMID:25996066

  2. Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes.

    PubMed

    Altun, Mikael; Kramer, Holger B; Willems, Lianne I; McDermott, Jeffrey L; Leach, Craig A; Goldenberg, Seth J; Kumar, K G Suresh; Konietzny, Rebecca; Fischer, Roman; Kogan, Edward; Mackeen, Mukram M; McGouran, Joanna; Khoronenkova, Svetlana V; Parsons, Jason L; Dianov, Grigory L; Nicholson, Benjamin; Kessler, Benedikt M

    2011-11-23

    Converting lead compounds into drug candidates is a crucial step in drug development, requiring early assessment of potency, selectivity, and off-target effects. We have utilized activity-based chemical proteomics to determine the potency and selectivity of deubiquitylating enzyme (DUB) inhibitors in cell culture models. Importantly, we characterized the small molecule PR-619 as a broad-range DUB inhibitor, and P22077 as a USP7 inhibitor with potential for further development as a chemotherapeutic agent in cancer therapy. A striking accumulation of polyubiquitylated proteins was observed after both selective and general inhibition of cellular DUB activity without direct impairment of proteasomal proteolysis. The repertoire of ubiquitylated substrates was analyzed by tandem mass spectrometry, identifying distinct subsets for general or specific inhibition of DUBs. This enabled identification of previously unknown functional links between USP7 and enzymes involved in DNA repair. PMID:22118674

  3. Accepting risk in the acceleration of drug development for rare cancers.

    PubMed

    Ashley, David; Thomas, David; Gore, Lia; Carter, Rob; Zalcberg, John R; Otmar, Renée; Savulescu, Julian

    2015-04-01

    Rare cancers collectively contribute a disproportionate fraction of the total burden of cancer. The oncology community is increasingly facing small numbers of patients with each cancer subtype, requiring cooperation and collaboration to complete multicentre trials that advance knowledge and patient care. At the same time, new insights into the biology of rare cancers have led to an explosion in knowledge and development of targeted agents. These insights and techniques are set to revolutionise the care of patients with cancer. However, drug development strategies and the availability of new agents for rare cancers are at risk of stalling owing to the ever-increasing complexity and costs of clinical trials. Finding solutions to these problems is imperative to the future of cancer care. We propose that a greater degree of risk sharing is needed than is currently accepted to enable the use of new methods with confidence, and to keep pace with scientific advancement. PMID:25846099

  4. Digital technologies for cognitive assessment to accelerate drug development in Alzheimer's disease.

    PubMed

    Leurent, C; Ehlers, M D

    2015-11-01

    For many neurological and psychiatric diseases, novel therapeutics have been elusive for decades. By focusing on attention interference in Alzheimer's disease (AD), we provide a future vision on how emerging mobile, computer, and device-based cognitive tools are converting classically noisy, subjective, data-poor clinical endpoints associated with neuropsychiatric disease assessment into a richer, scalable, and objective set of measurements. Incorporation of such endpoints into clinical drug trials holds promise for more quickly and efficiently developing new medicines. PMID:26272508

  5. Accelerating health equity: the key role of universal health coverage in the Sustainable Development Goals.

    PubMed

    Tangcharoensathien, Viroj; Mills, Anne; Palu, Toomas

    2015-01-01

    The Sustainable Development Goals (SDGs), to be committed to by Heads of State at the upcoming 2015 United Nations General Assembly, have set much higher and more ambitious health-related goals and targets than did the Millennium Development Goals (MDGs). The main challenge among MDG off-track countries is the failure to provide and sustain financial access to quality services by communities, especially the poor. Universal health coverage (UHC), one of the SDG health targets indispensable to achieving an improved level and distribution of health, requires a significant increase in government investment in strengthening primary healthcare - the close-to-client service which can result in equitable access. Given the trend of increased fiscal capacity in most developing countries, aiming at long-term progress toward UHC is feasible, if there is political commitment and if focused, effective policies are in place. Trends in high income countries, including an aging population which increases demand for health workers, continue to trigger international migration of health personnel from low and middle income countries. The inspirational SDGs must be matched with redoubled government efforts to strengthen health delivery systems, produce and retain more and relevant health workers, and progressively realize UHC. PMID:25925656

  6. Enriched environment restricted to gestation accelerates the development of sensory and motor circuits in the rat pup.

    PubMed

    Cárdenas, Lorena; García-García, Fabio; Santiago-Roque, Isela; Martínez, Armando J; Coria-Ávila, Genaro A; Corona-Morales, Aleph A

    2015-04-01

    The effects of stimulating environments on the neural plasticity of the adult brain have been well explored; however, how an enriched environment (EE) affects the mother-fetus interaction is poorly understood. We hypothesized that an enriched environment restricted to pregnancy will succeed in accelerating the development of sensory and motor circuits in the offspring. Pregnant Wistar rats were maintained either under a standard condition - two animals per standard cage- or an enriched environment - eight subjects in larger cages with different physical configurations-. After birth, litters from both groups (n=16 per group) were cross-fostered with mothers that were simultaneously maintained under standard environment during pregnancy. Sensory and motor development were studied in the pups of both groups with a battery of reflex and physical tests. Auditory and gait reflexes appeared two days earlier in the offspring of EE rats as compared to control subjects (p<0.05). In addition, EE pups displayed a better performance in righting reflex, inclined board and geotaxis tests (p<0.05). Differences were found even three weeks after birth. We conclude that EE limited to the phase of pregnancy stimulates the development of pups inutero so that they are born with a higher grade of development. PMID:25578294

  7. Ship-Based Nuclear Energy Systems for Accelerating Developing World Socioeconomic Advance

    NASA Astrophysics Data System (ADS)

    Petroski, Robert; Wood, Lowell

    2014-07-01

    Technological, economic, and policy aspects of supplying energy to newly industrializing and developing countries using ship-deployed nuclear energy systems are described. The approach analyzed comprises nuclear installations of up to gigawatt scale deployed within currently mass-produced large ship hulls which are capable of flexibly supplying energy for electricity, water desalination and district heating-&-cooling with low latencies and minimized shoreside capital expenditures. Nuclear energy is uniquely suited for mobile deployment due to its combination of extraordinary energy density and high power density, which enable enormous supplies of energy to be deployed at extremely low marginal costs. Nuclear installations on ships also confer technological advantages by essentially eliminating risk from earthquakes, tsunamis, and floods; taking advantage of assured access to an effectively unlimited amount of cooling water, and involving minimal onshore preparations and commitments. Instances of floating nuclear power stations that have been proposed in the past, some of which are currently being pursued, have generally been based on conventional LWR technology, moreover without flexibility or completeness of power output options. We consider nuclear technology options for their applicability to the unique opportunities and challenges of a marine environment, with special attention given to low-pressure, high thermal margin systems with continuous and assured afterheat dissipation into the ambient seawater. Such systems appear promising for offering an exceptionally high degree of safety while using a maximally simple set of components. We furthermore consider systems tailored to Developing World contexts, which satisfy societal requirements beyond electrification, e.g., flexible sourcing of potable water and HVAC services, servicing time-varying user requirements, and compatibility with the full spectrum of local renewable energy supplies, specifically including

  8. Accelerating the developing of carbon sequestration technologies. Electricity technology roadmap: limiting challenge No. 11. Final report

    SciTech Connect

    S. Dalton

    2003-12-15

    The report describes the R & D work needed to develop integrated carbon capture, transport, and storage technologies essential to reducing emissions associated with fossil fuel power generation. It incorporates extensive input from: representatives of the electric power industry, oil and gas companies, international research institutions, national laboratories, government agencies, environmental nonprofit organisations and academia. EPRI staff then worked intensively to interpret the inputs from this broad spectrum of contributors, and expand them into a systematic set of needs and recommendations. The document supports the 2003 Electricity Technology Roadmap. 10 figs., 2 tabs.

  9. Development of Rutherford-type cables for high field accelerator magnets at Fermilab

    SciTech Connect

    Andreev, N.; Barzi, E.; Borissov, E.; Elementi, L.; Kashikhin, V.S.; Lombardo, V.; Rusy, A.; Turrioni, D.; Yamada, R.; Zlobin, A.V.; /Fermilab

    2006-08-01

    Fermilab's cabling facility has been upgraded to a maximum capability of 42 strands. This facility is being used to study the effect of cabling on the performance of the various strands, and for the development and fabrication of cables in support of the ongoing magnet R&D programs. Rutherford cables of various geometries, packing factors, with and without a stainless steel core, were fabricated out of Cu alloys, NbTi, Nb{sub 3}Al, and various Nb{sub 3}Sn strands. The parameters of the upgraded cabling machine and results of cable R&D efforts at Fermilab are reported.

  10. Multicore and Accelerator Development for a Leadership-Class Stellar Astrophysics Code

    SciTech Connect

    Messer, Bronson; Harris, James A; Parete-Koon, Suzanne T; Chertkow, Merek A

    2013-01-01

    We describe recent development work on the core-collapse supernova code CHIMERA. CHIMERA has consumed more than 100 million cpu-hours on Oak Ridge Leadership Computing Facility (OLCF) platforms in the past 3 years, ranking it among the most important applications at the OLCF. Most of the work described has been focused on exploiting the multicore nature of the current platform (Jaguar) via, e.g., multithreading using OpenMP. In addition, we have begun a major effort to marshal the computational power of GPUs with CHIMERA. The impending upgrade of Jaguar to Titan a 20+ PF machine with an NVIDIA GPU on many nodes makes this work essential.

  11. Accelerated aging of cellulose by laser irradiation. [Development for Shroud of Turin

    SciTech Connect

    Jackson, J.P.; Arthurs, E.; Schwalbe, L.A.; Sega, R.M.; Windish, D.; Long, W.H.; Stappaerts, E.A.

    1988-01-01

    We describe a new technique for studying thermally-induced chemical transformations in cellulose developed for the Shroud of Turin. The apparatus consists of a carbon dioxide laser for heating, an infrared thermometer, and an optical reflectance spectrometer for tracking the progressive discoloration of the sample. To illustrate the technique, we present measurements from a single piece of sample linen along five isotherms in the range 200-290/degree/C. The results are explained in terms of first-order chemical rate theory and a four-step model. From the measurements we derive the activation energies, Arrhenius constants, and reflectivities of the chromophoric states. 4 refs., 2 figs., 1 tab.

  12. Environmental concentration of carbamazepine accelerates fish embryonic development and disturbs larvae behavior.

    PubMed

    Qiang, Liyuan; Cheng, Jinping; Yi, Jun; Rotchell, Jeanette M; Zhu, Xiaotong; Zhou, Junliang

    2016-09-01

    Environmental pollution caused by pharmaceuticals has been recognized as a major threat to the aquatic ecosystems. Carbamazepine, as the widely prescribed antiepileptic drug, has been frequently detected in the aquatic environment and has created concerns about its potential impacts in the aquatic organisms. The effects of carbamazepine on zebrafish embryos were studied by examining their phenotype, behavior and molecular responses. The results showed that carbamazepine disturbed the normal growth and development of exposed zebrafish embryos and larvae. Upon exposure to carbamazepine at 1 μg/L, the hatching rate, body length, swim bladder appearance and yolk sac absorption rate were significantly increased. Embryos in treatment groups were more sensitive to touch and light stimulation. At molecular level, exposure to an environmentally relevant concentration (1 μg/L) of carbamazepine disturbed the expression pattern of neural-related genes of zebrafish embryos and larvae. This study suggests that the exposure of fish embryo to antiepileptic drugs, at environmentally relevant concentrations, affects their early development and impairs their behavior. Such impacts may have future repercussions by affecting fish population structure. PMID:27386877

  13. Mathematical Model-Based Accelerated Development of Extended-release Metformin Hydrochloride Tablet Formulation.

    PubMed

    Chen, W; Desai, D; Good, D; Crison, J; Timmins, P; Paruchuri, S; Wang, J; Ha, K

    2016-08-01

    A computational fluid dynamic (CFD) model was developed to predict metformin release from a hydroxypropylmethylcellulose (HPMC) matrix-based extended-release formulation that took into consideration the physical and chemical properties of the drug substance, composition, as well as size and shape of the tablet. New high dose strength (1000 mg) tablet geometry was selected based on the surface area/volume (SA/V) approach advocated by Lapidus/Lordi/Reynold to obtain the desired equivalent metformin release kinetics. Maintaining a similar SA/V ratio across all extended-release metformin hydrochloride (Met XR) tablet strengths that had different geometries provided similar simulations of dissolution behavior. Experimental dissolution profiles of three lots of high-strength tablets agreed with the simulated release kinetics. Additionally, a pharmacokinetic absorption model was developed using GastroPlus™ software and known physicochemical, pharmacokinetic, and in vitro dissolution properties of metformin to predict the clinical exposure of the new high strength (1000 mg) tablet prior to conducting a human clinical bioequivalence study. In vitro metformin release kinetics were utilized in the absorption model to predict exposures in humans for new 1000-mg Met XR tablets, and the absorption model correctly projected equivalent in vivo exposure across all dose strengths. A clinical bioequivalence study was pursued based on the combined modeling results and demonstrated equivalent exposure as predicted by the simulations. PMID:26729531

  14. Accelerating Seed Germination and seedling development of Sorghum (Sorghum bicolor L. Moench) through hydro-priming

    NASA Astrophysics Data System (ADS)

    Dembele, S., Jr.

    2015-12-01

    Mali, a West Africa Sahelian country, is characterized by a strong dependence on rain-fed agriculture and a low adaptive capacity, making it one of the most vulnerable regions to climate change worldwide. Moreover, although with high uncertainties, most climate models used for the region recognize a growing uncertainty in the onset of the rainy season, which demands urgent adaptation measures. Early-season drought limits crops germination, and hence growth, and yield during rainfed depending production as is common now in Mali, West Africa. Crops germination and establishment could be improved by using seed priming, a process that dry seeds take up water to initiate the primary stages of germination, but the amount of water added is not enough for completing germination. The effects of hydro-priming (distilled, tap, rain, river and well water) were evaluated for three priming durations (4, 8 and 12 hour) in 2014 and 2015. Monitored were seed germination and seedling development of nine sorghum genotypes. Preliminary results showed that hydro-priming significantly improved germination rate, germination speed, number of seminal root, rate of survival and seedling vigour index, compared to non-primed seed treatments. However, seedling length, root length, shoot length and seedling dry weight did not differ significantly. Four out of the nine genotypes evaluated were attributed good seed quality and good response to hydro-priming. The priming with different sources of water resulted in higher seed germination (90%) and seedling development with well and river water, compared to the others. Seed germination rate, uniformity and speed were also enhanced by hydro-priming. It is argued that hydro-priming is a simple but effective method for improving seed germination and seedling development of sorghum. In addition hydro-priming is a safe, simple and inexpensive method to enhance germination. The most promising genotypes have consequently been included in consequent pot

  15. Development of an Electromagnetic Acceleration Facility for Impact and Fracture Studies at High Strain Rates

    NASA Astrophysics Data System (ADS)

    Pahari, S.; Suryaprasad, I. V. V.; Shiv, N.; Madhavan, S.; Sijoy, C. D.; Chaturvedi, S.

    2011-07-01

    Experimental studies of strain time history and fracture & penetration resulting from the high velocity impact of solid projectiles on solid targets have been initiated. Design, fabrication, testing and commissioning of an electromagnetic impact facility driven by a capacitor bank have been carried out in this regard. The facility presently has an induction coil gun driving a cylindrical hollow/solid projectile on to a target. 3-7 kJ capacitor banks have been used to drive the launchers. The parameters of the coil gun are in consonance with a computer code developed in-house for the validation and optimization of the coil dimension and bank parameters. Systematic studies have been carried out for validation of code and understanding and benchmarking coil performance. Reproducible velocities of the order of 100 m/s have been successfully achieved with projectiles of masses 20 gm. Preliminary impact studies carried out on Alumnium target plates have given the strain time history.

  16. [Development of an accelerated method of determining the antibiotic sensitivity of Cl. perfringens type A].

    PubMed

    Zemlianitskaia, E P; Kurbanova, I Z; Sergeeva, T I

    1979-02-01

    An express method for determination of antibiotic sensitivity in the strains of Cl. perfringens of type A using Soviet dry nutrient media and antibiotics is proposed. The criteria for estimation of the level of the antibiotic sensitivity of the causative agent of gas gangrene in short periods on the basis of comparison of the data of the antibiotic agar diffusion procedure and the antibiotic MIC were worked out. Twelve antibiotics and 45 collection strains of Cl. perfringens of type A were used in the experiment. The antibiotic agar diffusion method with the use of the nutrient media, microbial load and cultivation conditions developed by the authors is recommended for tentative determination of the antibiotic sensitivity in Cl. perfringens of type A for 4 hours. The use of the agar diffusion method and determination of the antibiotic MIC provided complete estimation of tha antibiotic sensitivity of Cl. perfringens of type A within not more than 24 hours. PMID:219770

  17. Urbanization Increases Aedes albopictus Larval Habitats and Accelerates Mosquito Development and Survivorship

    PubMed Central

    Li, Yiji; Kamara, Fatmata; Zhou, Guofa; Puthiyakunnon, Santhosh; Li, Chunyuan; Liu, Yanxia; Zhou, Yanhe; Yao, Lijie; Yan, Guiyun; Chen, Xiao-Guang

    2014-01-01

    Introduction Aedes albopictus is a very invasive and aggressive insect vector that causes outbreaks of dengue fever, chikungunya disease, and yellow fever in many countries. Vector ecology and disease epidemiology are strongly affected by environmental changes. Urbanization is a worldwide trend and is one of the most ecologically modifying phenomena. The purpose of this study is to determine how environmental changes due to urbanization affect the ecology of Aedes albopictus. Methods Aquatic habitats and Aedes albopictus larval population surveys were conducted from May to November 2013 in three areas representing rural, suburban, and urban settings in Guangzhou, China. Ae. albopictus adults were collected monthly using BG-Sentinel traps. Ae. albopictus larva and adult life-table experiments were conducted with 20 replicates in each of the three study areas. Results The urban area had the highest and the rural area had the lowest number of aquatic habitats that tested positive for Ae. albopictus larvae. Densities in the larval stages varied among the areas, but the urban area had almost two-fold higher densities in pupae and three-fold higher in adult populations compared with the suburban and rural areas. Larvae developed faster and the adult emergence rate was higher in the urban area than in suburban and rural areas. The survival time of adult mosquitoes was also longer in the urban area than it was in suburban and rural areas. Study regions, surface area, water depth, water clearance, surface type, and canopy coverage were important factors associated with the presence of Ae. albopictus larvae. Conclusions Urbanization substantially increased the density, larval development rate, and adult survival time of Ae. albopictus, which in turn potentially increased the vector capacity, and therefore, disease transmissibility. Mosquito ecology and its correlation with dengue virus transmission should be compared in different environmental settings. PMID:25393814

  18. Effects of Sled Towing on Peak Force, the Rate of Force Development and Sprint Performance During the Acceleration Phase

    PubMed Central

    Martínez-Valencia, María Asunción; Romero-Arenas, Salvador; Elvira, José L.L.; González-Ravé, José María; Navarro-Valdivielso, Fernando; Alcaraz, Pedro E.

    2015-01-01

    Resisted sprint training is believed to increase strength specific to sprinting. Therefore, the knowledge of force output in these tasks is essential. The aim of this study was to analyze the effect of sled towing (10%, 15% and 20% of body mass (Bm)) on sprint performance and force production during the acceleration phase. Twenty-three young experienced sprinters (17 men and 6 women; men = 17.9 ± 3.3 years, 1.79 ± 0.06 m and 69.4 ± 6.1 kg; women = 17.2 ± 1.7 years, 1.65 ± 0.04 m and 56.6 ± 2.3 kg) performed four 30 m sprints from a crouch start. Sprint times in 20 and 30 m sprint, peak force (Fpeak), a peak rate of force development (RFDpeak) and time to RFD (TRFD) in first step were recorded. Repeated-measures ANOVA showed significant increases (p ≤ 0.001) in sprint times (20 and 30 m sprint) for each resisted condition as compared to the unloaded condition. The RFDpeak increased significantly when a load increased (3129.4 ± 894.6 N·s−1, p ≤ 0.05 and 3892.4 ± 1377.9 N·s−1, p ≤ 0.01). Otherwise, no significant increases were found in Fpeak and TRFD. The RFD determines the force that can be generated in the early phase of muscle contraction, and it has been considered a factor that influences performance of force-velocity tasks. The use of a load up to 20% Bm might provide a training stimulus in young sprinters to improve the RFDpeak during the sprint start, and thus, early acceleration. PMID:26240657

  19. Effects of Sled Towing on Peak Force, the Rate of Force Development and Sprint Performance During the Acceleration Phase.

    PubMed

    Martínez-Valencia, María Asunción; Romero-Arenas, Salvador; Elvira, José L L; González-Ravé, José María; Navarro-Valdivielso, Fernando; Alcaraz, Pedro E

    2015-06-27

    Resisted sprint training is believed to increase strength specific to sprinting. Therefore, the knowledge of force output in these tasks is essential. The aim of this study was to analyze the effect of sled towing (10%, 15% and 20% of body mass (Bm)) on sprint performance and force production during the acceleration phase. Twenty-three young experienced sprinters (17 men and 6 women; men = 17.9 ± 3.3 years, 1.79 ± 0.06 m and 69.4 ± 6.1 kg; women = 17.2 ± 1.7 years, 1.65 ± 0.04 m and 56.6 ± 2.3 kg) performed four 30 m sprints from a crouch start. Sprint times in 20 and 30 m sprint, peak force (Fpeak), a peak rate of force development (RFDpeak) and time to RFD (TRFD) in first step were recorded. Repeated-measures ANOVA showed significant increases (p ≤ 0.001) in sprint times (20 and 30 m sprint) for each resisted condition as compared to the unloaded condition. The RFDpeak increased significantly when a load increased (3129.4 ± 894.6 N·s-1, p ≤ 0.05 and 3892.4 ± 1377.9 N·s-1, p ≤ 0.01). Otherwise, no significant increases were found in Fpeak and TRFD. The RFD determines the force that can be generated in the early phase of muscle contraction, and it has been considered a factor that influences performance of force-velocity tasks. The use of a load up to 20% Bm might provide a training stimulus in young sprinters to improve the RFDpeak during the sprint start, and thus, early acceleration. PMID:26240657

  20. Laser acceleration with open waveguides

    SciTech Connect

    Xie, Ming

    1999-03-01

    A unified framework based on solid-state open waveguides is developed to overcome all three major limitations on acceleration distance and hence on the feasibility of two classes of laser acceleration. The three limitations are due to laser diffraction, acceleration phase slippage, and damage of waveguide structure by high power laser. The two classes of laser acceleration are direct-field acceleration and ponderomotive-driven acceleration. Thus the solutions provided here encompass all mainstream approaches for laser acceleration, either in vacuum, gases or plasmas.

  1. Accelerating the Development of Formal Thinking in Pakistan Secondary School Students: Achievement Effects and Professional Development Issues.

    ERIC Educational Resources Information Center

    Iqbal, Hafiz M.; Shayer, Michael

    2000-01-01

    Reports on the results of using, in the context of secondary education in Pakistan, an intervention program which earlier was shown in British schools to have a substantial effect over a two-year period on the cognitive development of pupils. (Author/CCM)

  2. AT2 DS II - Accelerator System Design (Part II) - CCC Video Conference

    ScienceCinema

    None

    2011-10-06

    Discussion Session - Accelerator System Design (Part II) Tutors: C. Darve, J. Weisend II, Ph. Lebrun, A. Dabrowski, U. Raich Video Conference with the CERN Control Center. Experts in the field of Accelerator science will be available to answer the students questions. This session will link the CCC and SA (using Codec VC).

  3. AT2 DS II - Accelerator System Design (Part II) - CCC Video Conference

    SciTech Connect

    2010-12-17

    Discussion Session - Accelerator System Design (Part II) Tutors: C. Darve, J. Weisend II, Ph. Lebrun, A. Dabrowski, U. Raich Video Conference with the CERN Control Center. Experts in the field of Accelerator science will be available to answer the students questions. This session will link the CCC and SA (using Codec VC).

  4. Recommendations for the development of rare disease drugs using the accelerated approval pathway and for qualifying biomarkers as primary endpoints.

    PubMed

    Kakkis, Emil D; O'Donovan, Mary; Cox, Gerald; Hayes, Mark; Goodsaid, Federico; Tandon, P K; Furlong, Pat; Boynton, Susan; Bozic, Mladen; Orfali, May; Thornton, Mark

    2015-01-01

    For rare serious and life-threatening disorders, there is a tremendous challenge of transforming scientific discoveries into new drug treatments. This challenge has been recognized by all stakeholders who endorse the need for flexibility in the regulatory review process for novel therapeutics to treat rare diseases. In the United States, the best expression of this flexibility was the creation of the Accelerated Approval (AA) pathway. The AA pathway is critically important for the development of treatments for diseases with high unmet medical need and has been used extensively for drugs used to treat cancer and infectious diseases like HIV.In 2012, the AA provisions were amended to enhance the application of the AA pathway to expedite the development of drugs for rare disorders under the Food and Drug Administration Safety and Innovation Act (FDASIA). FDASIA, among many provisions, requires the development of a more relevant FDA guidance on the types of evidence that may be acceptable in support of using a novel surrogate endpoint. The application of AA to rare diseases requires more predictability to drive greater access to appropriate use of AA for more rare disease treatments that might not be developed otherwise.This white paper proposes a scientific framework for assessing biomarker endpoints to enhance the development of novel therapeutics for rare and devastating diseases currently without adequate treatment and is based on the opinions of experts in drug development and rare disease patient groups. Specific recommendations include: 1) Establishing regulatory rationale for increased AA access in rare disease programs; 2) Implementing a Biomarker Qualification Request Process to provide the opportunity for an early determination of biomarker acceptance; and 3) A proposed scientific framework for qualifying biomarkers as primary endpoints. The paper's final section highlights case studies of successful examples that have incorporated biomarker endpoints into

  5. Strategic HRD. [Concurrent Symposium Session at AHRD Annual Conference, 1998.

    ERIC Educational Resources Information Center

    1998

    This document contains four papers from a symposium on strategic human resource development (HRD). "The GEICO Challenge Session: A Model for Integrating Human Resource Development and Strategic Planning" (Clyde T. Conine, Jr., Bill P. Criswell) reports on a study that delineated the nature of the integration of HRD into the strategic planning…

  6. Powered by DFT: Screening methods that accelerate materials development for hydrogen in metals applications.

    PubMed

    Nicholson, Kelly M; Chandrasekhar, Nita; Sholl, David S

    2014-11-18

    CONSPECTUS: Not only is hydrogen critical for current chemical and refining processes, it is also projected to be an important energy carrier for future green energy systems such as fuel cell vehicles. Scientists have examined light metal hydrides for this purpose, which need to have both good thermodynamic properties and fast charging/discharging kinetics. The properties of hydrogen in metals are also important in the development of membranes for hydrogen purification. In this Account, we highlight our recent work aimed at the large scale screening of metal-based systems with either favorable hydrogen capacities and thermodynamics for hydrogen storage in metal hydrides for use in onboard fuel cell vehicles or promising hydrogen permeabilities relative to pure Pd for hydrogen separation from high temperature mixed gas streams using dense metal membranes. Previously, chemists have found that the metal hydrides need to hit a stability sweet spot: if the compound is too stable, it will not release enough hydrogen under low temperatures; if the compound is too unstable, the reaction may not be reversible under practical conditions. Fortunately, we can use DFT-based methods to assess this stability via prediction of thermodynamic properties, equilibrium reaction pathways, and phase diagrams for candidate metal hydride systems with reasonable accuracy using only proposed crystal structures and compositions as inputs. We have efficiently screened millions of mixtures of pure metals, metal hydrides, and alloys to identify promising reaction schemes via the grand canonical linear programming method. Pure Pd and Pd-based membranes have ideal hydrogen selectivities over other gases but suffer shortcomings such as sensitivity to sulfur poisoning and hydrogen embrittlement. Using a combination of detailed DFT, Monte Carlo techniques, and simplified models, we are able to accurately predict hydrogen permeabilities of metal membranes and screen large libraries of candidate alloys

  7. Antioxidant supplementation accelerates cachexia development by promoting tumor growth in C26 tumor-bearing mice.

    PubMed

    Assi, Mohamad; Derbré, Frédéric; Lefeuvre-Orfila, Luz; Rébillard, Amélie

    2016-02-01

    More than 50% of patients with advanced stages of colon cancer suffer from progressive loss of skeletal muscle, called cachexia, resulting in reduced quality of life and shortened survival. It is becoming evident that reactive oxygen species (ROS) regulate pathways controlling skeletal muscle atrophy. Herein we tested the hypothesis that antioxidant supplementation could prevent skeletal muscle atrophy in a model of cachectic Colon 26 (C26) tumor-bearing mice. Seven-week-old BALB/c mice were subcutaneously inoculated with colon 26 (C26) cancer cells or PBS. Then C26-mice were daily gavaged during 22 days either with PBS (vehicle) or an antioxidant cocktail whose composition is close to that of commercial dietary antioxidant supplements (rich in catechins, quercetin and vitamin C). We found that antioxidants enhanced weight loss and caused premature death of mice. Antioxidants supplementation failed to prevent (i) the increase in plasma TNF-α levels and systemic oxidative damage, (ii) skeletal muscle atrophy and (iii) activation of the ubiquitin-proteasome system (MuRF-1, MAFbx and polyubiquitinated proteins). Accordingly, immunohistological staining for Ki-67 and the expression of cell cycle inhibitors demonstrated that tumor of supplemented mice developed faster with a concomitant decrease in oxidative damage. Previous studies have shown that the use of catechins and quercetin separately can improve the musculoskeletal function in cachectic animals. However, our results indicate that the combination of these antioxidants reduced survival and enhanced cachexia in C26-mice. PMID:26708754

  8. Policies for accelerating access to clean energy, improving health, advancing development, and mitigating climate change.

    PubMed

    Haines, Andy; Smith, Kirk R; Anderson, Dennis; Epstein, Paul R; McMichael, Anthony J; Roberts, Ian; Wilkinson, Paul; Woodcock, James; Woods, Jeremy

    2007-10-01

    The absence of reliable access to clean energy and the services it provides imposes a large disease burden on low-income populations and impedes prospects for development. Furthermore, current patterns of fossil-fuel use cause substantial ill-health from air pollution and occupational hazards. Impending climate change, mainly driven by energy use, now also threatens health. Policies to promote access to non-polluting and sustainable sources of energy have great potential both to improve public health and to mitigate (prevent) climate disruption. There are several technological options, policy levers, and economic instruments for sectors such as power generation, transport, agriculture, and the built environment. However, barriers to change include vested interests, political inertia, inability to take meaningful action, profound global inequalities, weak technology-transfer mechanisms, and knowledge gaps that must be addressed to transform global markets. The need for policies that prevent dangerous anthropogenic interference with the climate while addressing the energy needs of disadvantaged people is a central challenge of the current era. A comprehensive programme for clean energy should optimise mitigation and, simultaneously, adaption to climate change while maximising co-benefits for health--eg, through improved air, water, and food quality. Intersectoral research and concerted action, both nationally and internationally, will be required. PMID:17868819

  9. Development of structural health assessment system for steel and reinforced concrete structures using acceleration data

    NASA Astrophysics Data System (ADS)

    Suzuki, Yu; Mita, Akira

    2014-03-01

    Because of the repeated earthquake and the problem such as the aging of buildings, a number of studies of Structural Health Monitoring (SHM) is have been done. Now, the writer is developing structural health assessment system for steel and reinforced concrete structures aiming for completion in 2014. In this system, following three programs for automatically estimating the physical quantity that is important for assessing the integrity of the structure are planned. First program is what automatically estimate the modal parameters (natural frequency and damping ratio) of the structure by the time history by using the subspace method. Second program is what automatically estimate the inter-layer parameters (stiffness and damping coefficient) by the time history by using the adaptive Kalman filter. Third program is what automatically estimate the story drift angle by time history by using the adaptive Kalman filter. The proposed method is expected to be estimated in consideration of the higher order modes than the conventional method by reverse modal analysis.

  10. Development of a GPU-Accelerated 3-D Full-Wave Code for Reflectometry Simulations

    NASA Astrophysics Data System (ADS)

    Reuther, K. S.; Kubota, S.; Feibush, E.; Johnson, I.

    2013-10-01

    1-D and 2-D full-wave codes used as synthetic diagnostics in microwave reflectometry are standard tools for understanding electron density fluctuations in fusion plasmas. The accuracy of the code depends on how well the wave properties along the ignored dimensions can be pre-specified or neglected. In a toroidal magnetic geometry, such assumptions are never strictly correct and ray tracing has shown that beam propagation is inherently a 3-D problem. Previously, we reported on the application of GPGPU's (General-Purpose computing on Graphics Processing Units) to a 2-D FDTD (Finite-Difference Time-Domain) code ported to utilize the parallel processing capabilities of the NVIDIA C870 and C1060. Here, we report on the development of a FDTD code for 3-D problems. Initial tests will use NVIDIA's M2070 GPU and concentrate on the launching and propagation of Gaussian beams in free space. If available, results using a plasma target will also be presented. Performance will be compared with previous generations of GPGPU cards as well as with NVIDIA's newest K20C GPU. Finally, the possibility of utilizing multiple GPGPU cards in a cluster environment or in a single node will also be discussed. Supported by U.S. DoE Grants DE-FG02-99-ER54527 and DE-AC02-09CH11466 and the DoE National Undergraduate Fusion Fellowship.

  11. Multi-processor developments in the United States for future high energy physics experiments and accelerators

    SciTech Connect

    Gaines, I.

    1988-03-01

    The use of multi-processors for analysis and high-level triggering in High Energy Physics experiments, pioneered by the early emulator systems, has reached maturity, in particular with the multiple microprocessor systems in use at Fermilab. It is widely acknowledged that such systems will fulfill the major portion of the computing needs of future large experiments. Recent developments at Fermilab's Advanced Computer Program will make such systems even more powerful, cost-effective, and easier to use than they are at present. The next generation of microprocessors, already available, will provide CPU power of about one VAX 780 equivalent/$300, while supporting most VMS FORTRAN extensions and large (>8MB) amounts of memory. Low cost high density mass storage devices (based on video tape cartridge technology) will allow parallel I/O to remove potential I/O bottlenecks in systems of over 1000 VAX equipment processors. New interconnection schemes and system software will allow more flexible topologies and extremely high data bandwidth, especially for on-line systems. This talk will summarize the work at the Advanced Computer Program and the rest of the US in this field. 3 refs., 4 figs.

  12. Virtual Neurorobotics (VNR) to Accelerate Development of Plausible Neuromorphic Brain Architectures

    PubMed Central

    Goodman, Philip H.; Buntha, Sermsak; Zou, Quan; Dascalu, Sergiu-Mihai

    2007-01-01

    Traditional research in artificial intelligence and machine learning has viewed the brain as a specially adapted information-processing system. More recently the field of social robotics has been advanced to capture the important dynamics of human cognition and interaction. An overarching societal goal of this research is to incorporate the resultant knowledge about intelligence into technology for prosthetic, assistive, security, and decision support applications. However, despite many decades of investment in learning and classification systems, this paradigm has yet to yield truly “intelligent” systems. For this reason, many investigators are now attempting to incorporate more realistic neuromorphic properties into machine learning systems, encouraged by over two decades of neuroscience research that has provided parameters that characterize the brain's interdependent genomic, proteomic, metabolomic, anatomic, and electrophysiological networks. Given the complexity of neural systems, developing tenable models to capture the essence of natural intelligence for real-time application requires that we discriminate features underlying information processing and intrinsic motivation from those reflecting biological constraints (such as maintaining structural integrity and transporting metabolic products). We propose herein a conceptual framework and an iterative method of virtual neurorobotics (VNR) intended to rapidly forward-engineer and test progressively more complex putative neuromorphic brain prototypes for their ability to support intrinsically intelligent, intentional interaction with humans. The VNR system is based on the viewpoint that a truly intelligent system must be driven by emotion rather than programmed tasking, incorporating intrinsic motivation and intentionality. We report pilot results of a closed-loop, real-time interactive VNR system with a spiking neural brain, and provide a video demonstration as online supplemental material. PMID:18958272

  13. Developing Subdomain Allocation Algorithms Based on Spatial and Communicational Constraints to Accelerate Dust Storm Simulation.

    PubMed

    Gui, Zhipeng; Yu, Manzhu; Yang, Chaowei; Jiang, Yunfeng; Chen, Songqing; Xia, Jizhe; Huang, Qunying; Liu, Kai; Li, Zhenlong; Hassan, Mohammed Anowarul; Jin, Baoxuan

    2016-01-01

    Dust storm has serious disastrous impacts on environment, human health, and assets. The developments and applications of dust storm models have contributed significantly to better understand and predict the distribution, intensity and structure of dust storms. However, dust storm simulation is a data and computing intensive process. To improve the computing performance, high performance computing has been widely adopted by dividing the entire study area into multiple subdomains and allocating each subdomain on different computing nodes in a parallel fashion. Inappropriate allocation may introduce imbalanced task loads and unnecessary communications among computing nodes. Therefore, allocation is a key factor that may impact the efficiency of parallel process. An allocation algorithm is expected to consider the computing cost and communication cost for each computing node to minimize total execution time and reduce overall communication cost for the entire simulation. This research introduces three algorithms to optimize the allocation by considering the spatial and communicational constraints: 1) an Integer Linear Programming (ILP) based algorithm from combinational optimization perspective; 2) a K-Means and Kernighan-Lin combined heuristic algorithm (K&K) integrating geometric and coordinate-free methods by merging local and global partitioning; 3) an automatic seeded region growing based geometric and local partitioning algorithm (ASRG). The performance and effectiveness of the three algorithms are compared based on different factors. Further, we adopt the K&K algorithm as the demonstrated algorithm for the experiment of dust model simulation with the non-hydrostatic mesoscale model (NMM-dust) and compared the performance with the MPI default sequential allocation. The results demonstrate that K&K method significantly improves the simulation performance with better subdomain allocation. This method can also be adopted for other relevant atmospheric and numerical

  14. Developing Subdomain Allocation Algorithms Based on Spatial and Communicational Constraints to Accelerate Dust Storm Simulation

    PubMed Central

    Gui, Zhipeng; Yu, Manzhu; Yang, Chaowei; Jiang, Yunfeng; Chen, Songqing; Xia, Jizhe; Huang, Qunying; Liu, Kai; Li, Zhenlong; Hassan, Mohammed Anowarul; Jin, Baoxuan

    2016-01-01

    Dust storm has serious disastrous impacts on environment, human health, and assets. The developments and applications of dust storm models have contributed significantly to better understand and predict the distribution, intensity and structure of dust storms. However, dust storm simulation is a data and computing intensive process. To improve the computing performance, high performance computing has been widely adopted by dividing the entire study area into multiple subdomains and allocating each subdomain on different computing nodes in a parallel fashion. Inappropriate allocation may introduce imbalanced task loads and unnecessary communications among computing nodes. Therefore, allocation is a key factor that may impact the efficiency of parallel process. An allocation algorithm is expected to consider the computing cost and communication cost for each computing node to minimize total execution time and reduce overall communication cost for the entire simulation. This research introduces three algorithms to optimize the allocation by considering the spatial and communicational constraints: 1) an Integer Linear Programming (ILP) based algorithm from combinational optimization perspective; 2) a K-Means and Kernighan-Lin combined heuristic algorithm (K&K) integrating geometric and coordinate-free methods by merging local and global partitioning; 3) an automatic seeded region growing based geometric and local partitioning algorithm (ASRG). The performance and effectiveness of the three algorithms are compared based on different factors. Further, we adopt the K&K algorithm as the demonstrated algorithm for the experiment of dust model simulation with the non-hydrostatic mesoscale model (NMM-dust) and compared the performance with the MPI default sequential allocation. The results demonstrate that K&K method significantly improves the simulation performance with better subdomain allocation. This method can also be adopted for other relevant atmospheric and numerical

  15. Developmental acceleration of bradykinin-dependent relaxation by prenatal chronic hypoxia impedes normal development after birth.

    PubMed

    Blum-Johnston, Carla; Thorpe, Richard B; Wee, Chelsea; Romero, Monica; Brunelle, Alexander; Blood, Quintin; Wilson, Rachael; Blood, Arlin B; Francis, Michael; Taylor, Mark S; Longo, Lawrence D; Pearce, William J; Wilson, Sean M

    2016-02-01

    Bradykinin-induced activation of the pulmonary endothelium triggers nitric oxide production and other signals that cause vasorelaxation, including stimulation of large-conductance Ca(2+)-activated K(+) (BKCa) channels in myocytes that hyperpolarize the plasma membrane and decrease intracellular Ca(2+). Intrauterine chronic hypoxia (CH) may reduce vasorelaxation in the fetal-to-newborn transition and contribute to pulmonary hypertension of the newborn. Thus we examined the effects of maturation and CH on the role of BKCa channels during bradykinin-induced vasorelaxation by examining endothelial Ca(2+) signals, wire myography, and Western immunoblots on pulmonary arteries isolated from near-term fetal (∼ 140 days gestation) and newborn, 10- to 20-day-old, sheep that lived in normoxia at 700 m or in CH at high altitude (3,801 m) for >100 days. CH enhanced bradykinin-induced relaxation of fetal vessels but decreased relaxation in newborns. Endothelial Ca(2+) responses decreased with maturation but increased with CH. Bradykinin-dependent relaxation was sensitive to 100 μM nitro-L-arginine methyl ester or 10 μM 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one, supporting roles for endothelial nitric oxide synthase and soluble guanylate cyclase activation. Indomethacin blocked relaxation in CH vessels, suggesting upregulation of PLA2 pathways. BKCa channel inhibition with 1 mM tetraethylammonium reduced bradykinin-induced vasorelaxation in the normoxic newborn and fetal CH vessels. Maturation reduced whole cell BKCa channel α1-subunit expression but increased β1-subunit expression. These results suggest that CH amplifies the contribution of BKCa channels to bradykinin-induced vasorelaxation in fetal sheep but stunts further development of this vasodilatory pathway in newborns. This involves complex changes in multiple components of the bradykinin-signaling axes. PMID:26637638

  16. Targeted disruption of fibrinogen like protein-1 accelerates hepatocellular carcinoma development

    SciTech Connect

    Nayeb-Hashemi, Hamed; Desai, Anal; Demchev, Valeriy; Bronson, Roderick T.; Hornick, Jason L.; Cohen, David E.; Ukomadu, Chinweike

    2015-09-18

    Fibrinogen like protein-1 (Fgl1) is a predominantly liver expressed protein that has been implicated as both a hepatoprotectant and a hepatocyte mitogen. Fgl1 expression is decreased in hepatocellular carcinoma (HCC) and its loss correlates with a poorly differentiated phenotype. To better elucidate the role of Fgl1 in hepatocarcinogenesis, we treated mice wild type or null for Fgl1 with diethyl nitrosamine and monitored for incidence of hepatocellular cancer. We find that mice lacking Fgl1 develop HCC at more than twice the rate of wild type mice. We show that hepatocellular cancers from Fgl1 null mice are molecularly distinct from those of the wild type mice. In tumors from Fgl1 null mice there is enhanced activation of Akt and downstream targets of the mammalian target of rapamycin (mTOR). In addition, there is paradoxical up regulation of putative hepatocellular cancer tumor suppressors; tripartite motif-containing protein 35 (Trim35) and tumor necrosis factor super family 10b (Tnfrsf10b). Taken together, these findings suggest that Fgl1 acts as a tumor suppressor in hepatocellular cancer through an Akt dependent mechanism and supports its role as a potential therapeutic target in HCC. - Highlights: • Fgl1 knockout mice (Fgl1KO) are more prone to carcinogen-induced liver cancer compared to wild type (WT) mates. • Tumors from the Fgl1KO are molecularly distinct with enhanced Akt and mTOR activity in comparison with Fgl1WT tumors. • Tumors from the Fgl1KO have enhanced expression of Trim35 and Tnfrsf10b, putative HCC tumor suppressors.

  17. Session: Program Review X Wrap-Up

    SciTech Connect

    1992-01-01

    This wrap-up session at the Geothermal Energy Program Review X: Geothermal Energy and the Utility Market consisted of Closing Remarks by Roland R. Kessler and six NGA Industry Critique Panel presentations: ''Summary of Comments on DOE-Industry Cooperation by Geothermal Industry Panel'' by James B. Koenig, GeothermEx, Inc.; ''NGA Industry Critique of the Exploration Component'' by Joe L. Iovenitti, Weiss Associates; ''Critique of Drilling Research'' by Jerry Hamblin, UNOCAL Geothermal; ''Critique Panel Comments on Reservoir Engineering, DOE Geothermal Technology Development'' by Dennis Kaspereit, California Energy Company, Inc.; ''DOE Geothermal Program Review - Critique on Production'' by Douglas B. Jung, Two-Phase Engineering and Research; ''Comments on the DOE Hydrothermal Energy Conversion R&D Program'' by David L. Mendive, Geothermal Development Associates.

  18. The Dielectric Wall Accelerator

    SciTech Connect

    Caporaso, George J.; Chen, Yu-Jiuan; Sampayan, Stephen E.

    2009-01-01

    The Dielectric Wall Accelerator (DWA), a class of induction accelerators, employs a novel insulating beam tube to impress a longitudinal electric field on a bunch of charged particles. The surface flashover characteristics of this tube may permit the attainment of accelerating gradients on the order of 100 MV/m for accelerating pulses on the order of a nanosecond in duration. A virtual traveling wave of excitation along the tube is produced at any desired speed by controlling the timing of pulse generating modules that supply a tangential electric field to the tube wall. Because of the ability to control the speed of this virtual wave, the accelerator is capable of handling any charge to mass ratio particle; hence it can be used for electrons, protons and any ion. The accelerator architectures, key technologies and development challenges will be described.

  19. Utilization of Practice Session Average Inertial Load to Quantify College Football Injury Risk.

    PubMed

    Wilkerson, Gary B; Gupta, Ashish; Allen, Jeff R; Keith, Clay M; Colston, Marisa A

    2016-09-01

    Wilkerson, GB, Gupta, A, Allen, JR, Keith, CM, and Colston, MA. Utilization of practice session average inertial load to quantify college football injury risk. J Strength Cond Res 30(9): 2369-2374, 2016-Relatively few studies have investigated the potential injury prevention value of data derived from recently developed wearable technology for measurement of body mass accelerations during the performance of sport-related activities. The available evidence has been derived from studies focused on avoidance of overtraining syndrome, which is believed to induce a chronically fatigued state that can be identified through monitoring of inertial load accumulation. Reduced variability in movement patterns is also believed to be an important injury risk factor, but no evidence currently exists to guide interpretation of data derived from inertial measurement units (IMUs) in this regard. We retrospectively analyzed archived data for a cohort of 45 National Collegiate Athletic Association Division 1-football bowl subdivision football players who wore IMUs on the upper back during practice sessions to quantify any associations between average inertial load measured during practice sessions and occurrence of musculoskeletal sprains and strains. Both the coefficient of variation for average inertial load and frequent exposure to game conditions were found to be strongly associated with injury occurrence. Having either or both of the 2 risk factors provided strong discrimination between injured and noninjured players (χ = 9.048; p = 0.004; odds ratio = 8.04; 90% CI: 2.39, 27.03). Our findings may facilitate identification of individual football players who are likely to derive the greatest benefit from training activities designed to reduce injury risk through improved adaptability to rapidly changing environmental demands. PMID:26849792

  20. Osteoblast ablation reduces normal long-term hematopoietic stem cell self-renewal but accelerates leukemia development

    PubMed Central

    Bowers, Marisa; Zhang, Bin; Ho, Yinwei; Agarwal, Puneet; Chen, Ching-Cheng

    2015-01-01

    Hematopoietic stem cells (HSCs) reside in regulatory niches in the bone marrow (BM). Although HSC niches have been extensively characterized, the role of endosteal osteoblasts (OBs) in HSC regulation requires further clarification, and the role of OBs in regulating leukemic stem cells (LSCs) is not well studied. We used an OB visualization and ablation mouse model to study the role of OBs in regulating normal HSCs and chronic myelogenous leukemia (CML) LSCs. OB ablation resulted in increase in cells with a LSK Flt3−CD150+CD48− long-term HSC (LTHSC) phenotype but reduction of a more highly selected LSK Flt3−CD34−CD49b−CD229− LTHSC subpopulation. LTHSCs from OB-ablated mice demonstrated loss of quiescence and reduced long-term engraftment and self-renewal capacity. Ablation of OB in a transgenic CML mouse model resulted in accelerated leukemia development with reduced survival compared with control mice. The notch ligand Jagged-1 was overexpressed on CML OBs. Normal and CML LTHSCs cultured with Jagged-1 demonstrated reduced cell cycling, consistent with a possible role for loss of Jagged-1 signals in altered HSC and LSC function after OB ablation. These studies support an important role for OBs in regulating quiescence and self-renewal of LTHSCs and a previously unrecognized role in modulating leukemia development in CML. PMID:25742698