Gender differences in head-neck segment dynamic stabilization during head acceleration.

PubMed

Tierney, Ryan T; Sitler, Michael R; Swanik, C Buz; Swanik, Kathleen A; Higgins, Michael; Torg, Joseph

2005-02-01

Recent epidemiological research has revealed that gender differences exist in concussion incidence but no study has investigated why females may be at greater risk of concussion. Our purpose was to determine whether gender differences existed in head-neck segment kinematic and neuromuscular control variables responses to an external force application with and without neck muscle preactivation. Forty (20 females and 20 males) physically active volunteers participated in the study. The independent variables were gender, force application (known vs unknown), and force direction (forced flexion vs forced extension). The dependent variables were kinematic and EMG variables, head-neck segment stiffness, and head-neck segment flexor and extensor isometric strength. Statistical analyses consisted of multiple multivariate and univariate analyses of variance, follow-up univariate analyses of variance, and t-tests (P < or = 0.05). Gender differences existed in head-neck segment dynamic stabilization during head angular acceleration. Females exhibited significantly greater head-neck segment peak angular acceleration (50%) and displacement (39%) than males despite initiating muscle activity significantly earlier (SCM only) and using a greater percentage of their maximum head-neck segment muscle activity (79% peak activity and 117% muscle activity area). The head-neck segment angular acceleration differences may be because females exhibited significantly less isometric strength (49%), neck girth (30%), and head mass (43%), resulting in lower levels of head-neck segment stiffness (29%). For our subject demographic, the results revealed gender differences in head-neck segment dynamic stabilization during head acceleration in response to an external force application. Females exhibited significantly greater head-neck segment peak angular acceleration and displacement than males despite initiating muscle activity earlier (SCM only) and using a greater percentage of their maximum

Physicochemical stability and biological activity of Withania somnifera extract under real-time and accelerated storage conditions.

PubMed

Patil, Dada; Gautam, Manish; Jadhav, Umesh; Mishra, Sanjay; Karupothula, Suresh; Gairola, Sunil; Jadhav, Suresh; Patwardhan, Bhushan

2010-03-01

Stability testing at preformulation stages is a crucial part of drug development. We studied physicochemical stability and biological activity of Withania somnifera (ashwagandha) dried root aqueous extract during six months real-time and under accelerated storage conditions. The characteristic constituents of ashwagandha roots include withanolides such as withaferin A and withanolide A. We modified and validated the HPLC-DAD method for quantitative measurement of withanolides and fingerprint analysis. The results suggest a significant decline in withaferin A and withanolide A content under real and accelerated conditions. The HPLC fingerprint analysis showed significant changes in some peaks during real and accelerated storage (> 20 %). We also observed incidences of clump formation and moisture sensitivity (> 10 %) under real-time and accelerated storage conditions. These changes were concurrent with a significant decline in immunomodulatory activity (p < 0.01) during the third month of the accelerated storage. Thus, adequate control of temperature and humidity is important for WSE containing formulations. This study may help in proposing suitable guidance for storage conditions and shelf life of ashwagandha formulations. (c) Georg Thieme Verlag KG Stuttgart . New York.

Accelerated testing for studying pavement design and performance (FY 2003) : evaluation of the chemical stabilized subgrade soil (CISL Experiment No. 12).

DOT National Transportation Integrated Search

2008-01-01

The Midwest States Accelerated Pavement Testing Pooled Fund Program, financed by the highway departments : of Missouri, Iowa, Kansas and Nebraska, has supported an accelerated pavement testing (APT) project to compare : the performance of stabilized ...

Inviscid linear stability analysis of two vertical columns of different densities in a gravitational acceleration field

DOE PAGES

Prathama, Aditya Heru; Pantano, Carlos

2017-08-09

Here, we study the inviscid linear stability of a vertical interface separating two fluids of different densities and subject to a gravitational acceleration field parallel to the interface. In this arrangement, the two free streams are constantly accelerated, which means that the linear stability analysis is not amenable to Fourier or Laplace solution in time. Instead, we derive the equations analytically by the initial-value problem method and express the solution in terms of the well-known parabolic cylinder function. The results, which can be classified as an accelerating Kelvin–Helmholtz configuration, show that even in the presence of surface tension, the interfacemore » is unconditionally unstable at all wavemodes. This is a consequence of the ever increasing momentum of the free streams, as gravity accelerates them indefinitely. The instability can be shown to grow as the exponential of a quadratic function of time.« less

Statistical evaluation of accelerated stability data obtained at a single temperature. I. Effect of experimental errors in evaluation of stability data obtained.

PubMed

Yoshioka, S; Aso, Y; Takeda, Y

1990-06-01

Accelerated stability data obtained at a single temperature is statistically evaluated, and the utility of such data for assessment of stability is discussed focussing on the chemical stability of solution-state dosage forms. The probability that the drug content of a product is observed to be within the lower specification limit in the accelerated test is interpreted graphically. This probability depends on experimental errors in the assay and temperature control, as well as the true degradation rate and activation energy. Therefore, the observation that the drug content meets the specification in the accelerated testing can provide only limited information on the shelf-life of the drug, without the knowledge of the activation energy and the accuracy and precision of the assay and temperature control.

Accelerated Storage Stability and Corrosion Characteristics Study Protocol

EPA Pesticide Factsheets

EPA has determined that studies using this protocol will, in certain circumstances, provide the Agency with all the information it needs to make a determination on the storage stability of pesticides.

Fractional Stability of Trunk Acceleration Dynamics of Daily-Life Walking: Toward a Unified Concept of Gait Stability

PubMed Central

Ihlen, Espen A. F.; van Schooten, Kimberley S.; Bruijn, Sjoerd M.; Pijnappels, Mirjam; van Dieën, Jaap H.

2017-01-01

Over the last decades, various measures have been introduced to assess stability during walking. All of these measures assume that gait stability may be equated with exponential stability, where dynamic stability is quantified by a Floquet multiplier or Lyapunov exponent. These specific constructs of dynamic stability assume that the gait dynamics are time independent and without phase transitions. In this case the temporal change in distance, d(t), between neighboring trajectories in state space is assumed to be an exponential function of time. However, results from walking models and empirical studies show that the assumptions of exponential stability break down in the vicinity of phase transitions that are present in each step cycle. Here we apply a general non-exponential construct of gait stability, called fractional stability, which can define dynamic stability in the presence of phase transitions. Fractional stability employs the fractional indices, α and β, of differential operator which allow modeling of singularities in d(t) that cannot be captured by exponential stability. The fractional stability provided an improved fit of d(t) compared to exponential stability when applied to trunk accelerations during daily-life walking in community-dwelling older adults. Moreover, using multivariate empirical mode decomposition surrogates, we found that the singularities in d(t), which were well modeled by fractional stability, are created by phase-dependent modulation of gait. The new construct of fractional stability may represent a physiologically more valid concept of stability in vicinity of phase transitions and may thus pave the way for a more unified concept of gait stability. PMID:28900400

Acceleration and stability of a high-current ion beam in induction fields

NASA Astrophysics Data System (ADS)

Karas', V. I.; Manuilenko, O. V.; Tarakanov, V. P.; Federovskaya, O. V.

2013-03-01

A one-dimensional nonlinear analytic theory of the filamentation instability of a high-current ion beam is formulated. The results of 2.5-dimensional numerical particle-in-cell simulations of acceleration and stability of an annular compensated ion beam (CIB) in a linear induction particle accelerator are presented. It is shown that additional transverse injection of electron beams in magnetically insulated gaps (cusps) improves the quality of the ion-beam distribution function and provides uniform beam acceleration along the accelerator. The CIB filamentation instability in both the presence and the absence of an external magnetic field is considered.

Stability analysis of multigrid acceleration methods for the solution of partial differential equations

NASA Technical Reports Server (NTRS)

Fay, John F.

1990-01-01

A calculation is made of the stability of various relaxation schemes for the numerical solution of partial differential equations. A multigrid acceleration method is introduced, and its effects on stability are explored. A detailed stability analysis of a simple case is carried out and verified by numerical experiment. It is shown that the use of multigrids can speed convergence by several orders of magnitude without adversely affecting stability.

Kinetic Modeling of Accelerated Stability Testing Enabled by Second Harmonic Generation Microscopy.

PubMed

Song, Zhengtian; Sarkar, Sreya; Vogt, Andrew D; Danzer, Gerald D; Smith, Casey J; Gualtieri, Ellen J; Simpson, Garth J

2018-04-03

The low limits of detection afforded by second harmonic generation (SHG) microscopy coupled with image analysis algorithms enabled quantitative modeling of the temperature-dependent crystallization of active pharmaceutical ingredients (APIs) within amorphous solid dispersions (ASDs). ASDs, in which an API is maintained in an amorphous state within a polymer matrix, are finding increasing use to address solubility limitations of small-molecule APIs. Extensive stability testing is typically performed for ASD characterization, the time frame for which is often dictated by the earliest detectable onset of crystal formation. Here a study of accelerated stability testing on ritonavir, a human immunodeficiency virus (HIV) protease inhibitor, has been conducted. Under the condition for accelerated stability testing at 50 °C/75%RH and 40 °C/75%RH, ritonavir crystallization kinetics from amorphous solid dispersions were monitored by SHG microscopy. SHG microscopy coupled by image analysis yielded limits of detection for ritonavir crystals as low as 10 ppm, which is about 2 orders of magnitude lower than other methods currently available for crystallinity detection in ASDs. The four decade dynamic range of SHG microscopy enabled quantitative modeling with an established (JMAK) kinetic model. From the SHG images, nucleation and crystal growth rates were independently determined.

Improved Magnetron Stability and Reduced Noise in Efficient Transmitters for Superconducting Accelerators

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kazakevich, G.; Johnson, R.; Lebedev, V.

State of the art high-current superconducting accelerators require efficient RF sources with a fast dynamic phase and power control. This allows for compensation of the phase and amplitude deviations of the accelerating voltage in the Superconducting RF (SRF) cavities caused by microphonics, etc. Efficient magnetron transmitters with fast phase and power control are attractive RF sources for this application. They are more cost effective than traditional RF sources such as klystrons, IOTs and solid-state amplifiers used with large scale accelerator projects. However, unlike traditional RF sources, controlled magnetrons operate as forced oscillators. Study of the impact of the controlling signalmore » on magnetron stability, noise and efficiency is therefore important. This paper discusses experiments with 2.45 GHz, 1 kW tubes and verifies our analytical model which is based on the charge drift approximation.« less

Colour stability of denture teeth submitted to different cleaning protocols and accelerated artificial aging.

PubMed

Freire, T S; Aguilar, F G; Garcia, L da Fonseca Roberti; Pires-de-Souza, F de Carvalho Panzeri

2014-03-01

Acrylic resin is widely used for artificial teeth manufacturing due to several important characteristics; however, this material do not present acceptable colour stability over the course of time. This study evaluated the effect of different cleaning protocols and accelerated artificial aging on colour stability of denture teeth made of acrylic resin. Sixty denture teeth in dark and light shades were used, and separated according to the treatment to which they were submitted. Results demonstrated that colour stability of artificial teeth is influenced by the cleaning solution and artificial aging, being dark teeth more susceptible to colour alteration than lighter ones.

Stability of the accelerated expansion in nonlinear electrodynamics

NASA Astrophysics Data System (ADS)

Sharif, M.; Mumtaz, Saadia

2017-02-01

This paper is devoted to the phase space analysis of an isotropic and homogeneous model of the universe by taking a noninteracting mixture of the electromagnetic and viscous radiating fluids whose viscous pressure satisfies a nonlinear version of the Israel-Stewart transport equation. We establish an autonomous system of equations by introducing normalized dimensionless variables. In order to analyze the stability of the system, we find corresponding critical points for different values of the parameters. We also evaluate the power-law scale factor whose behavior indicates different phases of the universe in this model. It is concluded that the bulk viscosity as well as electromagnetic field enhances the stability of the accelerated expansion of the isotropic and homogeneous model of the universe.

Accelerated aging and stabilization of radiation-vulcanized EPDM rubber

NASA Astrophysics Data System (ADS)

Basfar, A. A.; Abdel-Aziz, M. M.; Mofti, S.

2000-03-01

The effect of different antioxidants and their mixtures on the thermal aging and accelerated weathering of γ-radiation vulcanized EPDM rubber in presence of crosslinking coagent, was investigated. The compounds used were either a synergistic blend of phenolic and phosphite antioxidants, i.e. 1:4 Irganox 1076: Irgafos 168 or a blend of arylamine and quinoline type antioxidants, i.e. 1:1 IPPD: TMQ, at fixed concentration. Tinuvin 622 LD hindered amine light stabilized (HALS) was also used. The response was evaluated by the tensile strength and elongation at break for irradiated samples after thermal aging at 100°C for 28 days and accelerated weathering (Xenon test) up to 200 h.

Colour stability of temporary restorations with different thicknesses submitted to artificial accelerated aging.

PubMed

Silame, F D J; Tonani, R; Alandia-Roman, C C; Chinelatti, M; Panzeri, H; Pires-de-Souza, F C P

2013-12-01

This study evaluated the colour stability of temporary prosthetic restorations with different thicknesses submitted to artificial accelerated aging. The occlusal surfaces of 40 molars were grinded to obtain flat enamel surfaces. Twenty acrylic resin specimens [Polymethyl methacrylate (Duralay) and Bis-methyl acrylate (Luxatemp)] were made with two different thicknesses, 0.5 mm and 1.0 mm. Temporary restorations were fixed on enamel and CIE L*a*b* colour parameters of each specimen were assessed before and after artificial accelerated aging. All groups showed colour alterations above the clinically acceptable limit. Luxatemp showed the lowest colour alteration regardless its thickness and Duralay showed the greatest alteration with 0.5 mm.

Vaccine stability study design and analysis to support product licensure.

PubMed

Schofield, Timothy L

2009-11-01

Stability evaluation supporting vaccine licensure includes studies of bulk intermediates as well as final container product. Long-term and accelerated studies are performed to support shelf life and to determine release limits for the vaccine. Vaccine shelf life is best determined utilizing a formal statistical evaluation outlined in the ICH guidelines, while minimum release is calculated to help assure adequate potency through handling and storage of the vaccine. In addition to supporting release potency determination, accelerated stability studies may be used to support a strategy to recalculate product expiry after an unintended temperature excursion such as a cold storage unit failure or mishandling during transport. Appropriate statistical evaluation of vaccine stability data promotes strategic stability study design, in order to reduce the uncertainty associated with the determination of the degradation rate, and the associated risk to the customer.

Stability of Lysozyme in Aqueous Extremolyte Solutions during Heat Shock and Accelerated Thermal Conditions

PubMed Central

van Streun, Erwin L. P.; Frijlink, Henderik W.; Hinrichs, Wouter L. J.

2014-01-01

The purpose of this study was to investigate the stability of lysozyme in aqueous solutions in the presence of various extremolytes (betaine, hydroxyectoine, trehalose, ectoine, and firoin) under different stress conditions. The stability of lysozyme was determined by Nile red Fluorescence Spectroscopy and a bioactivity assay. During heat shock (10 min at 70°C), betaine, trehalose, ectoin and firoin protected lysozyme against inactivation while hydroxyectoine, did not have a significant effect. During accelerated thermal conditions (4 weeks at 55°C), firoin also acted as a stabilizer. In contrast, betaine, hydroxyectoine, trehalose and ectoine destabilized lysozyme under this condition. These findings surprisingly indicate that some extremolytes can stabilize a protein under certain stress conditions but destabilize the same protein under other stress conditions. Therefore it is suggested that for the screening extremolytes to be used for protein stabilization, an appropriate storage conditions should also be taken into account. PMID:24465983

Stability of lysozyme in aqueous extremolyte solutions during heat shock and accelerated thermal conditions.

PubMed

Avanti, Christina; Saluja, Vinay; van Streun, Erwin L P; Frijlink, Henderik W; Hinrichs, Wouter L J

2014-01-01

The purpose of this study was to investigate the stability of lysozyme in aqueous solutions in the presence of various extremolytes (betaine, hydroxyectoine, trehalose, ectoine, and firoin) under different stress conditions. The stability of lysozyme was determined by Nile red Fluorescence Spectroscopy and a bioactivity assay. During heat shock (10 min at 70°C), betaine, trehalose, ectoin and firoin protected lysozyme against inactivation while hydroxyectoine, did not have a significant effect. During accelerated thermal conditions (4 weeks at 55°C), firoin also acted as a stabilizer. In contrast, betaine, hydroxyectoine, trehalose and ectoine destabilized lysozyme under this condition. These findings surprisingly indicate that some extremolytes can stabilize a protein under certain stress conditions but destabilize the same protein under other stress conditions. Therefore it is suggested that for the screening extremolytes to be used for protein stabilization, an appropriate storage conditions should also be taken into account.

Plug-in module acceleration feedback control for fast steering mirror-based beam stabilization systems

NASA Astrophysics Data System (ADS)

Deng, Chao; Ren, Wei; Mao, Yao; Ren, Ge

2017-08-01

A plug-in module acceleration feedback control (Plug-In AFC) strategy based on the disturbance observer (DOB) principle is proposed for charge-coupled device (CCD)-based fast steering mirror (FSM) stabilization systems. In classical FSM tracking systems, dual-loop control (DLC), including velocity feedback and position feedback, is usually utilized to enhance the closed-loop performance. Due to the mechanical resonance of the system and CCD time delay, the closed-loop bandwidth is severely restricted. To solve this problem, cascade acceleration feedback control (AFC), which is a kind of high-precision robust control method, is introduced to strengthen the disturbance rejection property. However, in practical applications, it is difficult to realize an integral algorithm in an acceleration controller to compensate for the quadratic differential contained in the FSM acceleration model, resulting in a challenging controller design and a limited improvement. To optimize the acceleration feedback framework in the FSM system, different from the cascade AFC, the accelerometers are used to construct DOB to compensate for the platform vibrations directly. The acceleration nested loop can be plugged into the velocity loop without changing the system stability, and the controller design is quite simple. A series of comparative experimental results demonstrate that the disturbance rejection property of the CCD-based FSM can be effectively improved by the proposed approach.

Catalyst Stability Benchmarking for the Oxygen Evolution Reaction: The Importance of Backing Electrode Material and Dissolution in Accelerated Aging Studies.

PubMed

Geiger, Simon; Kasian, Olga; Mingers, Andrea M; Nicley, Shannon S; Haenen, Ken; Mayrhofer, Karl J J; Cherevko, Serhiy

2017-09-18

In searching for alternative oxygen evolution reaction (OER) catalysts for acidic water splitting, fast screening of the material intrinsic activity and stability in half-cell tests is of vital importance. The screening process significantly accelerates the discovery of new promising materials without the need of time-consuming real-cell analysis. In commonly employed tests, a conclusion on the catalyst stability is drawn solely on the basis of electrochemical data, for example, by evaluating potential-versus-time profiles. Herein important limitations of such approaches, which are related to the degradation of the backing electrode material, are demonstrated. State-of-the-art Ir-black powder is investigated for OER activity and for dissolution as a function of the backing electrode material. Even at very short time intervals materials like glassy carbon passivate, increasing the contact resistance and concealing the degradation phenomena of the electrocatalyst itself. Alternative backing electrodes like gold and boron-doped diamond show better stability and are thus recommended for short accelerated aging investigations. Moreover, parallel quantification of dissolution products in the electrolyte is shown to be of great importance for comparing OER catalyst feasibility. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Accelerated Stability Testing of a Clobetasol Propionate-Loaded Nanoemulsion as per ICH Guidelines.

PubMed

Ali, Mohammad Sajid; Alam, Mohammad Sarfaraz; Alam, Nawazish; Anwer, Tarique; Safhi, Mohammed Mohsen A

2013-01-01

The physical and chemical degradation of drugs may result in altered therapeutic efficacy and even toxic effects. Therefore, the objective of this work was to study the stability of clobetasol propionate (CP) in a nanoemulsion. The nanoemulsion formulation containing CP was prepared by the spontaneous emulsification method. For the formulation of the nanoemulsion, Safsol, Tween 20, ethanol, and distilled water were used. The drug was incorporated into an oil phase in 0.05% w/v. The lipophilic nature of the drug led to the O/W nanoemulsion formulation. This was characterized by droplet size, pH, viscosity, conductivity, and refractive index. Stability studies were performed as per ICH guidelines for a period of three months. The shelf life of the nanoemulsion formulation was also determined after performing accelerated stability testing (40°C ± 2°C and 75% ± 5% RH). We also performed an intermediate stability study (30°C ± 2°C/65% RH ± 5% RH). It was found that the droplet size, conductivity, and refractive index were slightly increased, while the viscosity and pH slightly decreased at all storage conditions during the 3-month period. However, the changes in these parameters were not statistically significant (p≥0.05). The degradation (%) of the optimized nanoemulsion of CP was determined and the shelf life was found to be 2.18 years at room temperature. These studies confirmed that the physical and chemical stability of CP were enhanced in the nanoemulsion formulation.

Chromatic stability of acrylic resins of artificial eyes submitted to accelerated aging and polishing.

PubMed

Goiato, Marcelo Coelho; Santos, Daniela Micheline dos; Souza, Josiene Firmino; Moreno, Amália; Pesqueira, Aldiéris Alves

2010-12-01

Esthetics and durability of materials used to fabricate artificial eyes has been an important issue since artificial eyes are essential to restore esthetics and function, protect the remaining tissues and help with patients' psychological therapy. However, these materials are submitted to degrading effects of environmental agents on the physical properties of the acrylic resin. This study assessed the color stability of acrylic resins used to fabricate sclera in three basic shades (N1, N2 and N3) when subjected to accelerated aging, mechanical and chemical polishing. Specimens of each resin were fabricated and submitted to mechanical and chemical polishing. Chromatic analysis was performed before and after accelerated aging through ultraviolet reflection spectrophotometry. All specimens revealed color alteration following polishing and accelerated aging. The resins presented statistically significant chromatic alteration (p<0.01) between the periods of 252 and 1008 h. Both polishing methods presented no significant difference between the values of color derivatives of resins.

The effect of copper, MDA, and accelerated aging on jet fuel thermal stability as measured by the gravimetric JFTOT

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pande, S.G.; Hardy, D.R.

1995-05-01

Thermally unstable jet fuels pose operational problems. In order to adequately identify such fuels, factors that realistically impact on thermal stability were examined. Evaluation was based on a quantitative method of measuring thermal stability, viz., NRL`s recently developed gravimetric JFTOT. This method gives a quantitative measurement of both the strip deposit and filterables formed. The pertinent factors examined, included the individual and interactive effects of: soluble copper, MDA (metal deactivator), and aging. The latter was accelerated to simulate field conditions of approximately six months aging at ambient temperature and pressure. The results indicate that the individual and interactive effects ofmore » copper, MDA, and accelerated aging appear to be fuel dependent. Based on the results, the three test fuels examined (one JP-8 and two JP-5s) were categorized as exhibiting very good, typical, and poor thermal stabilities, respectively. For both the very good and poor thermal stability fuels, the effect of copper in conjunction with accelerated aging did not significantly increase the total thermal deposits of the neat fuels. In contrast, for the typical thermal stability fuel, the combined effects of copper and accelerated aging, did. Furthermore, the addition of MDA prior to aging of the copper-doped, typical stability fuel significantly counteracted the adverse effect of copper and aging. A similar beneficial effect of MDA was not observed for the poor stability fuel. These results focus on the compositional differences among fuels and the need to elucidate these differences (physical and chemical) for a better understanding and prediction of their performance.« less

Stability of Permanent Magnets,

DTIC Science & Technology

1984-03-06

temperature. The effect of impacts, vibrations and external magnetic fields in less detail is illuminated. The new, accelerated methods of the study of...accelerated methods, developed by the author of the study of the stability of magnets and systems, which do not require prolonged time intervais...the accelerated methods proposed to them of the study of the stability of magnets will contribute to the accumulation of experimental results and to

Evaluation of the effect of non-B DNA structures on plasmid integrity via accelerated stability studies.

PubMed

Ribeiro, S C; Monteiro, G A; Prazeres, D M F

2009-04-01

Plasmid biopharmaceuticals are a new class of medicines with an enormous potential. Attempts to increase the physical stability of highly purified supercoiled (SC) plasmid DNA in pharmaceutical aqueous solutions have relied on: (i) changing the DNA sequence, (ii) improving manufacturing to reduce deleterious impurities and initial DNA damage, and (iii) controlling the storage medium characteristics. In this work we analyzed the role of secondary structures on the degradation of plasmid molecules. Accelerated stability experiments were performed with SC, open circular (OC) and linear (L) isoforms of three plasmids which differed only in the "single-strandlike" content of their polyadenylation (poly A) signals. We have proved that the presence of more altered or interrupted (non-B) DNA secondary structures did not directly translate into an easier strand scission of the SC isoforms. Rather, those unusual structures imposed a lower degree of SC in the plasmids, leading to an increase in their resistance to thermal degradation. However, this behavior was reversed when the relaxed or L isoforms were tested, in which case the absence of SC rendered the plasmids essentially double-stranded. Overall, this work suggests that plasmid DNA sequence and secondary structures should be taken into account in future investigations of plasmid stability during prolonged storage.

Evaluation of accelerated stability test conditions for medicated chewing gums.

PubMed

Maggi, Lauretta; Conte, Ubaldo; Nhamias, Alain; Grenier, Pascal; Vergnault, Guy

2013-10-01

The overall stability of medicated chewing gums is investigated under different storage conditions. Active substances with different chemical stabilities in solid state are chosen as model drugs. The dosage form is a three layer tablet obtained by direct compression. The gum core contains the active ingredient while the external layers are formulated to prevent gum adhesion to the punches of the tableting machine. Two accelerated test conditions (40°C/75% RH and 30°C/65% RH) are performed for 6 months. Furthermore, a long-term stability test at room conditions is conducted to verify the predictability of the results obtained from the stress tests. Some drugs are stable in all the conditions tested, but other drugs, generally considered stable in solid dosage forms, have shown relevant stability problems particularly when stress test conditions are applied to this particular semi-solid dosage forms. For less stable drugs, the stress conditions of 40°C/75% RH are not always predictable of chewing gum stability at room temperature and may produce false negative; intermediate conditions, 30°C/65% RH, are more predictive for this purpose, the results of drug content found after 6 months at intermediate stress conditions and 12 months at room conditions are generally comparable. But the results obtained show that only long-term conditions stability tests gave consistent results. During aging, the semi solid nature of the gum base itself, may also influence the drug delivery rate during chewing and great attention should be given also to the dissolution stability.

Visual evaluation of color stability after accelerated aging of pigmented and nonpigmented silicones to be used in facial prostheses.

PubMed

Mancuso, Daniela Nardi; Goiato, Marcelo Coelho; Dekon, Stefan Fiuza de Carvalho; Gennari-Filho, Humberto

2009-01-01

The objective of this study was to evaluate by a visual method of comparison the color stability of nonpigmented and pigmented facial silicones after accelerated aging. Two kinds of silicones were used in this study; one specifically formulated for facial prostheses and the other an acetic silicone for industrial use. Twenty-four trial bodies were made for each silicone. These were divided into colorless and intrinsically pigmented groups: ceramic, make-up, and iron oxide. The groups were submitted to accelerated aging for nonmetallic materials. An initial reading and subsequent readings were made at 163, 351, 692, and 1000 hours using a visual method of comparison. The values were annotated in a spreadsheet by two observers, according to scores elaborated for this study. All groups presented color stability in the visual method. According to the results obtained and analyzed in this study, we can conclude that both silicones, Silastic 732 RTV and Silastic MDX 4-4210, behaved similarly, they can therefore be indicated for use in maxillofacial prosthesis. The time factor of aging influenced negatively, independently of the pigmentation, or lack of it, and of silicones and no group had visually noticeable alterations in any of the accelerated aging time, independently of the addition or not of pigments.

The effect of accelerated ageing on colour stability of visible light-cured (VLC) chairside denture liners.

PubMed

Kostoulas, Ioannis; Polyzois, Gregory; Mitsoudis, Anastasios; Kavoura, Victoria; Frangou, Maria

2012-06-01

The purpose of this study was to assess the colour stability of seven visible light-cured (VLC) hard and soft denture liners by an in vitro accelerated ageing test and compare them with two autopolymerised hard and soft liners. Ten specimens of each material were fabricated. The initial colour was measured with a tri-stimulus colorimeter. One set of five specimens was placed in distilled water at 37°C in the dark for 15 days, while the remaining were subjected to UV/visible light-accelerated ageing initially for 24 h and then for 144 h. Colour change (ΔΕ) was calculated. Data were statistically analysed by anova, Tukey and t-tests at α = 0.05. All the liners showed clinically acceptable colour change (ΔΕ ≤ 6.8) in distilled water. The colour changes after ageing for Triad DuaLine, Lightdon U, Ufi Gel H and Light Liner Hard were clinically unacceptable (ΔΕ ≥ 6.8), whereas LightLiner Soft, Astron LC Soft, Triad Resiline and Flexacryl Soft presented slighter and clinically acceptable colour change (ΔΕ ≤ 6.8). Accelerated ageing affected significantly the colour stability of all denture liners tested except Astron LC Soft. Soft VLC denture liners were more colour-stable than hard VLC liners. © 2011 The Gerodontology Society and John Wiley & Sons A/S.

A Quality by Design approach to investigate tablet dissolution shift upon accelerated stability by multivariate methods.

PubMed

Huang, Jun; Goolcharran, Chimanlall; Ghosh, Krishnendu

2011-05-01

This paper presents the use of experimental design, optimization and multivariate techniques to investigate root-cause of tablet dissolution shift (slow-down) upon stability and develop control strategies for a drug product during formulation and process development. The effectiveness and usefulness of these methodologies were demonstrated through two application examples. In both applications, dissolution slow-down was observed during a 4-week accelerated stability test under 51°C/75%RH storage condition. In Application I, an experimental design was carried out to evaluate the interactions and effects of the design factors on critical quality attribute (CQA) of dissolution upon stability. The design space was studied by design of experiment (DOE) and multivariate analysis to ensure desired dissolution profile and minimal dissolution shift upon stability. Multivariate techniques, such as multi-way principal component analysis (MPCA) of the entire dissolution profiles upon stability, were performed to reveal batch relationships and to evaluate the impact of design factors on dissolution. In Application II, an experiment was conducted to study the impact of varying tablet breaking force on dissolution upon stability utilizing MPCA. It was demonstrated that the use of multivariate methods, defined as Quality by Design (QbD) principles and tools in ICH-Q8 guidance, provides an effective means to achieve a greater understanding of tablet dissolution upon stability. Copyright © 2010 Elsevier B.V. All rights reserved.

Color stability of silorane-based composites submitted to accelerated artificial ageing--an in situ study.

PubMed

Pires-de-Souza, Fernanda de Carvalho Panzeri; Garcia, Lucas da Fonseca Roberti; Roselino, Lourenço de Moraes Rego; Naves, Lucas Zago

2011-07-01

To assess the in situ color stability, surface and the tooth/restoration interface degradation of a silorane-based composite (P90, 3M ESPE) after accelerated artificial ageing (AAA), in comparison with other dimethacrylate monomer-based composites (Z250/Z350, 3M ESPE and Esthet-X, Dentsply). Class V cavities (25 mm(2) × 2 mm deep) were prepared in 48 bovine incisors, which were randomly allocated into 4 groups of 12 specimens each, according to the type of restorative material used. After polishing, 10 specimens were submitted to initial color readings (Easyshade, Vita) and 2 to analysis by scanning electronic microscopy (SEM). Afterwards, the teeth were submitted to AAA for 384 h, which corresponds to 1 year of clinical use, after which new color readings and microscopic images were obtained. The values obtained for the color analysis were submitted to statistical analysis (1-way ANOVA, Tukey, p<0.05). With regard to color stability, it was verified that all the composites showed color alteration above the clinically acceptable levels (ΔE ≥ 3.3), and that the silorane-based composite showed higher ΔE (18.6), with a statistically significant difference in comparison with the other composites (p<0.05). The SEM images showed small alterations for the dimethacrylate-based composites after AAA and extensive degradation for the silorane-based composite with a rupture at the interface between the matrix/particle. It may be concluded that the silorane-based composite underwent greater alteration with regard to color stability and greater surface and tooth/restoration interface degradation after AAA. Copyright © 2011 Elsevier Ltd. All rights reserved.

Colour stability and opacity of resin cements and flowable composites for ceramic veneer luting after accelerated ageing.

PubMed

Archegas, Lucí Regina Panka; Freire, Andrea; Vieira, Sergio; Caldas, Danilo Biazzetto de Menezes; Souza, Evelise Machado

2011-11-01

Colour changes of the luting material can become clinically visible affecting the aesthetic appearance of thin ceramic laminates. The aim of this in vitro study was to evaluate the colour stability and opacity of light- and dual-cured resin cements and flowable composites after accelerated ageing. The luting agents were bonded (0.2 mm thick) to ceramic disks (0.75 mm thick) built with the pressed-ceramic IPS Aesthetic Empress (n=7). Colour measurements were determined using a FTIR spectrophotometer before and after accelerated ageing in a weathering machine with a total energy of 150 kJ. Changes in colour (ΔE) and opacity (ΔO) were obtained using the CIE L*a*b* system. The results were submitted to one-way ANOVA, Tukey HSD test and Student's t test (α=5%). All the materials showed significant changes in colour and opacity. The ΔE of the materials ranged from 0.41 to 2.40. The highest colour changes were attributed to RelyX ARC and AllCem, whilst lower changes were found in Variolink Veneer, Tetric Flow and Filtek Z350 Flow. The opacity of the materials ranged from -0.01 to 1.16 and its variation was not significant only for Opallis Flow and RelyX ARC. The accelerated ageing led to colour changes in all the evaluated materials, although they were considered clinically acceptable (ΔE<3). Amongst the dual-cured resin cements, Variolink II demonstrated the highest colour stability. All the flowable composites showed proper colour stability for the luting of ceramic veneers. After ageing, an increase in opacity was observed for most of the materials. Copyright © 2011 Elsevier Ltd. All rights reserved.

Use of induced acceleration to quantify the (de)stabilization effect of external and internal forces on postural responses.

PubMed

van Asseldonk, Edwin H F; Carpenter, Mark G; van der Helm, Frans C T; van der Kooij, Herman

2007-12-01

Due to the mechanical coupling between the body segments, it is impossible to see with the naked eye the causes of body movements and understand the interaction between movements of different body parts. The goal of this paper is to investigate the use of induced acceleration analysis to reveal the causes of body movements. We derive the analytical equations to calculate induced accelerations and evaluate its potential to study human postural responses to support-surface translations. We measured the kinematic and kinetic responses of a subject to sudden forward and backward translations of a moving platform. The kinematic and kinetics served as input to the induced acceleration analyses. The induced accelerations showed explicitly that the platform acceleration and deceleration contributed to the destabilization and restabilization of standing balance, respectively. Furthermore, the joint torques, coriolis and centrifugal forces caused by swinging of the arms, contributed positively to stabilization of the Center of Mass. It is concluded that induced acceleration analyses is a valuable tool in understanding balance responses to different kinds of perturbations and may help to identify the causes of movement in different pathologies.

The physical and chemical stability of anti-tuberculosis fixed-dose combination products under accelerated climatic conditions.

PubMed

Bhutani, H; Mariappan, T T; Singh, S

2004-09-01

To determine the physical and chemical stability of anti-tuberculosis fixed-dose combinations (FDC) of rifampicin (RMP), isoniazid (INH), pyrazinamide (PZA) and ethambutol (EMB) sold on the Indian market. The products were stored for 3 months under ICH/WHO accelerated conditions (40 degrees C / 75% RH), with and without the original packaging in the presence and absence of light. The initial RMP, INH and PZA content was found to be within the range of 90-110% of the label claim. However, the products were found to have some chemical instability even initially; one of the tablets also showed physical instability. Under accelerated conditions, the unpackaged products underwent severe changes, whereas both physical and chemical changes were also observed in the packaged formulations. The physical changes were stronger under lighted conditions. A significant finding is that PZA and perhaps EMB may play a catalytic role in the interaction between INH and RMP. This study suggests that, unless they are packed in barrier packaging, anti-tuberculosis FDC formulations should be considered unstable, and due consideration should be given to their development pharmaceutics, packaging and stability testing.

Recent results of studies of acceleration of compact toroids

NASA Astrophysics Data System (ADS)

Hammer, J. H.; Hartmen, C. W.; Eddleman, J.

1984-03-01

The observed gross stability and self-contained structure of compact toroids (CT's) give rise to the possibility, unique among magnetically confined plasmas, of translating CT's from their point of origin over distances many times their own length. This feature has led us to consider magnetic acceleration of CT's to directed kinetic energies much greater than their stored magnetic and thermal energies. A CT accelerator falls in the very broad gap between traditional particle accelerators at one extreme, which are limited in the number of particles per bunch by electrostatic repulsive forces, and mass accelerators such as rail guns at the other extreme, which accelerate many particles but are forced by the stress limitations of solids to far smaller accelerations. A typical CT has about a Coulomb of particles, weighs 10 micrograms and can be accelerated by magnetic forces of several tons, leading to an acceleration on the order of 10(11) gravities.

Accelerated testing for studying pavement design and performance (FY 2003) : research summary.

DOT National Transportation Integrated Search

2008-01-01

The Midwest States Accelerated Pavement Testing Pooled Fund Program, financed by : the highway departments of Missouri, Iowa, Kansas and Nebraska, has supported an : accelerated pavement testing (APT) project to compare the performance of stabilized ...

The application of the Accelerated Stability Assessment Program (ASAP) to quality by design (QbD) for drug product stability.

PubMed

Waterman, Kenneth Craig

2011-09-01

An isoconversion paradigm, where times in different temperature and humidity-controlled stability chambers are set to provide a fixed degradant level, is shown to compensate for the complex, non-single order kinetics of solid drug products. A humidity-corrected Arrhenius equation provides reliable estimates for temperature and relative humidity effects on degradation rates. A statistical protocol is employed to determine best fits for chemical stability data, which in turn allows for accurate estimations of shelf life (with appropriate confidence intervals) at any storage condition including inside packaging (based on the moisture vapor transmission rate of the packaging and moisture sorption isotherms of the internal components). These methodologies provide both faster results and far better predictions of chemical stability limited shelf life (expiry) than previously possible. Precise shelf-life estimations are generally determined using a 2-week, product-specific protocol. Once the model for a product is developed, it can play a critical role in providing the product understanding necessary for a quality by design (QbD) filing for product approval and enable rational control strategies to assure product stability. Moreover, this Accelerated Stability Assessment Program (ASAP) enables the coupling of product attributes (e.g., moisture content, packaging options) to allow for flexibility in how control strategies are implemented to provide a balance of cost, speed, and other factors while maintaining adequate stability.

Influence of artificial accelerated aging on the color stability and opacity of composites of different shades.

PubMed

Mundim, F M; Da Fonseca Roberti Garcia, L; Silva Sousa, A B; Cruvinel, D R; De Carvalho Panzeri Pires-De-Souza, F

2010-10-01

The aim of this study was to evaluate the influence of artificial accelerated aging on the color stability and opacity of composites of different shades. Four composites for direct use (Heliomolar, 4 Seasons, Tetric EvoCeram; QuiXfil) and one for indirect use (SR Adoro) in two shades were used: light (A2) and dark (C3 for direct, and D4 for indirect composite). QuiXfil was obtained in Universal shade. A Teflon matrix (12 X 2 mm) was used to obtain 54 specimens (N=6), which were submitted to color and opacity analysis (Spectrophotometer PCB 6807, Byk Gardner) before and after artificial accelerated aging for 384 hours. After the statistical analysis (2-way ANOVA - Bonferroni - P<0.05), significant color alteration was observed in the light and dark composites studied (P<0.05), with the exception of QuiXfil. Composite 4 Seasons/C3 showed less color alteration (ΔE=0.91). The opacity alteration (ΔOP) was higher for light composites. Artificial accelerated aging interfered in the optical properties assessed; however, the alterations seemed to be more related to the composites composition than to their shade.

Influence of surface sealing on color stability and roughness of composite submitted to ultraviolet-accelerated aging.

PubMed

Catelan, Anderson; Suzuki, Thaís Yumi Umeda; Becker, Francisco; Briso, André Luiz Fraga; Dos Santos, Paulo Henrique

2017-05-01

In the present study, we evaluated the influence of surface sealing on color stability and surface roughness of a composite resin after accelerated artificial aging. Thirty-two specimens of a composite were prepared. After 24 h, the specimens were polished and divided into four groups (n = 8), according to the surface sealant used, including the control, which had no sealant application. Baseline color was measured according to the CIELab system using a reflection spectrophotometer. Surface roughness was determined using a profilometer with a cut-off of 0.25 mm. After these tests, specimens were aged for 252 h in an ultraviolet (UV)-accelerated aging chamber. Color stability was determined by difference between coordinates obtained before and after the aging procedure. Data of color change and roughness were evaluated by anova and Fisher's exact test (α = 0.05). The results showed that the unsealed group had the highest color change compared to other groups (P = 0.0289), and there was no significant difference between groups sealed with surface sealant (P > 0.05). The artificial aging caused an increase in roughness values independent of the experimental group studied (P = 0.0015). The sealed composites showed lower color change after UV aging, but all groups showed clinically-acceptable color change, and only liquid polish decreased roughness. © 2016 John Wiley & Sons Australia, Ltd.

Rheological behavior, zeta potential, and accelerated stability tests of Buriti oil (Mauritia flexuosa) emulsions containing lyotropic liquid crystals.

PubMed

Zanatta, Cinthia Fernanda; de Faria Sato, Anne Miwa Callejón; de Camargo, Flavio Bueno; Campos, Patrícia Maria Berardo Gonçalves Maia; Rocha-Filho, Pedro Alves

2010-01-01

It is well known that the Amazon region presents a huge biodiversity; therefore, countless natural resources are being employed in the production of phytocosmetics and phytomedicines. The purpose of this work was to obtain emulsions produced with Buriti oil and non-ionic surfactants. Two surfactant systems were employed (Steareth-2 associated to Ceteareth-5 and to Ceteareth-20) to produce the emulsions using phase diagram method. Emulsions were obtained by echo-planar imaging method at 75°C. Rheological behavior and zeta potential were evaluated, and accelerated stability tests were performed. All emulsions analyzed presented pseudoplastic behavior. Zeta potential values were obtained between -14.2 and -53.3 mV. The formulations did not show changes in either physical stability, pH, or rheological behavior after accelerated stability tests. Significant differences were observed only after temperature cycling test. Based on these results, the emulsions obtained could be considered as promising delivery systems.

Comparative study of ageing, heat treatment and accelerated carbonation for stabilization of municipal solid waste incineration bottom ash in view of reducing regulated heavy metal/metalloid leaching.

PubMed

Santos, Rafael M; Mertens, Gilles; Salman, Muhammad; Cizer, Özlem; Van Gerven, Tom

2013-10-15

This study compared the performance of four different approaches for stabilization of regulated heavy metal and metalloid leaching from municipal solid waste incineration bottom ash (MSWI-BA): (i) short term (three months) heap ageing, (ii) heat treatment, (iii) accelerated moist carbonation, and (iv) accelerated pressurized slurry carbonation. Two distinct types of MSWI-BA were tested in this study: one originating from a moving-grate furnace incineration operation treating exclusively household refuse (sample B), and another originating from a fluid-bed furnace incineration operation that treats a mixture of household and light industrial wastes (sample F). The most abundant elements in the ashes were Si (20-27 wt.%) and Ca (16-19 wt.%), followed by significant quantities of Fe, Al, Na, S, K, Mg, Ti, and Cl. The main crystalline substances present in the fresh ashes were Quartz, Calcite, Apatite, Anhydrite and Gehlenite, while the amorphous fraction ranged from 56 to 73 wt.%. The leaching values of all samples were compared to the Flemish (NEN 7343) and the Walloon (DIN 38414) regulations from Belgium. Batch leaching of the fresh ashes at natural pH showed that seven elements exceeded at least one regulatory limit (Ba, Cr, Cu, Mo, Pb, Se and Zn), and that both ashes had excess basicity (pH > 12). Accelerated carbonation achieved significant reduction in ash basicity (9.3-9.9); lower than ageing (10.5-12.2) and heat treatment (11.1-12.1). For sample B, there was little distinction between the leaching results of ageing and accelerated carbonation with respect to regulatory limits; however carbonation achieved comparatively lower leaching levels. Heat treatment was especially detrimental to the leaching of Cr. For sample F, ageing was ineffective and heat treatment had marginally better results, while accelerated carbonation delivered the most effective performance, with slurry carbonation meeting all DIN limits. Slurry carbonation was deemed the most

Propagation and stability characteristics of a 500-m-long laser-based fiducial line for high-precision alignment of long-distance linear accelerators.

PubMed

Suwada, Tsuyoshi; Satoh, Masanori; Telada, Souichi; Minoshima, Kaoru

2013-09-01

A laser-based alignment system with a He-Ne laser has been newly developed in order to precisely align accelerator units at the KEKB injector linac. The laser beam was first implemented as a 500-m-long fiducial straight line for alignment measurements. We experimentally investigated the propagation and stability characteristics of the laser beam passing through laser pipes in vacuum. The pointing stability at the last fiducial point was successfully obtained with the transverse displacements of ±40 μm level in one standard deviation by applying a feedback control. This pointing stability corresponds to an angle of ±0.08 μrad. This report contains a detailed description of the experimental investigation for the propagation and stability characteristics of the laser beam in the laser-based alignment system for long-distance linear accelerators.

Indirect check of the stability of the reference ion chamber used for accelerator output calibration

NASA Astrophysics Data System (ADS)

Kang, Sei-Kwon; Yoon, Jai-Woong; Park, Soah; Hwang, Taejin; Cheong, Kwang-Ho; Han, Tae Jin; Kim, Haeyoung; Lee, Me-Yeon; Kim, Kyoung Ju; Bae, Hoonsik

2014-11-01

A linear accelerator's output is periodically checked by using a reference ion chamber which is also periodically calibrated at the accredited standard dosimetry laboratories. We suggest a simple procedure for checking the chamber's stability between calibrations by comparison with another ion chamber. To identify the long-term stability of chambers, we collected and assessed the dose-to-water conversion factors provided by standard laboratories for three chambers during a period of four years. To develop the chamber constancy check program, we used one Farmer-type reference ion chamber FC65-G, two ion chambers (CC13a and CC13b) and one CC01 ion chamber (IBA). Under the accelerator, each chamber was placed inside the solid phantom and irradiated; the experimental configurations were identical. To check the variation in charge collection of the reference chamber, we monitored the ratios of the FC65-G values over each chamber reading. Based on the error propagation of the two chamber ratios, we estimated the uncertainty of the output calibration from the chamber variation. The calibration factors provided for the three chambers showed 0.04 ˜ 0.12% standard deviations during four years. For procedure development, the reading ratios of FC65-G over CCxx showed very good stability; the ratios of FC65-G over CC13a, CC13b and CC01 varied less than 0.059, 0.087 and 0.248%, respectively, over five measurements. By ascribing possible uncertainties of the ratio to the reference chamber alone, we could conservatively check the stability of the reference chamber for treatment safety. An extension of the chamber calibration period was also evaluated. In conclusion, we designed a stability check procedure for the reference chamber based on a reading ratio of two chambers. This could help the user assess the chamber stability between periodic chamber calibration, and the associated patient treatment could be carried out with enhanced safety.

Propagation and stability characteristics of a 500-m-long laser-based fiducial line for high-precision alignment of long-distance linear accelerators

DOE Office of Scientific and Technical Information (OSTI.GOV)

Suwada, Tsuyoshi; Satoh, Masanori; Telada, Souichi

2013-09-15

A laser-based alignment system with a He-Ne laser has been newly developed in order to precisely align accelerator units at the KEKB injector linac. The laser beam was first implemented as a 500-m-long fiducial straight line for alignment measurements. We experimentally investigated the propagation and stability characteristics of the laser beam passing through laser pipes in vacuum. The pointing stability at the last fiducial point was successfully obtained with the transverse displacements of ±40 μm level in one standard deviation by applying a feedback control. This pointing stability corresponds to an angle of ±0.08 μrad. This report contains a detailedmore » description of the experimental investigation for the propagation and stability characteristics of the laser beam in the laser-based alignment system for long-distance linear accelerators.« less

Stabilization of soybean oil during accelerated storage by essential oil of ferulago angulata boiss.

PubMed

Sadeghi, Ehsan; Mahtabani, Aidin; Etminan, Alireza; Karami, Farahnaz

2016-02-01

This study has been considered effect of Ferulago angulata essential oil on stabilizing soybean oil during accelerated storage. The essential oil was extracted by Clevenger-type apparatus. For analysis of the essential oil, GC/MS was used. Main components of the essential oil were monoterpene and sesquiterpene hydrocarbons. The essential oil of F. angulata at four concentrations, i.e. 125 (SBO-125), 250 (SBO-250), 500 (SBO-500) and SBO-Mixture (60 ppm TBHQ +60 ppm essential oil) were added to preheated refined soybean oil. TBHQ was used at 120 ppm as standard besides the control. Antioxidant activity index (AAI), free fatty acid (FFA) content, peroxide value (PV) and p-anisidine value (p-AnV) were served for appreciation of efficacy of F. angulata in stabilization of soybean oil. Results from different tests showed that SBO-mixture had highest effect and followed by SBO-TBHQ, SBO-250, SBO-125, SBO-500 and Ctrl. These results reveal F. angulata is a strong antioxidant and can be used instead of synthetic antioxidant.

Arrhenius time-scaled least squares: a simple, robust approach to accelerated stability data analysis for bioproducts.

PubMed

Rauk, Adam P; Guo, Kevin; Hu, Yanling; Cahya, Suntara; Weiss, William F

2014-08-01

Defining a suitable product presentation with an acceptable stability profile over its intended shelf-life is one of the principal challenges in bioproduct development. Accelerated stability studies are routinely used as a tool to better understand long-term stability. Data analysis often employs an overall mass action kinetics description for the degradation and the Arrhenius relationship to capture the temperature dependence of the observed rate constant. To improve predictive accuracy and precision, the current work proposes a least-squares estimation approach with a single nonlinear covariate and uses a polynomial to describe the change in a product attribute with respect to time. The approach, which will be referred to as Arrhenius time-scaled (ATS) least squares, enables accurate, precise predictions to be achieved for degradation profiles commonly encountered during bioproduct development. A Monte Carlo study is conducted to compare the proposed approach with the common method of least-squares estimation on the logarithmic form of the Arrhenius equation and nonlinear estimation of a first-order model. The ATS least squares method accommodates a range of degradation profiles, provides a simple and intuitive approach for data presentation, and can be implemented with ease. © 2014 Wiley Periodicals, Inc. and the American Pharmacists Association.

Analysis of cerium-composite polymer-electrolyte membranes during and after accelerated oxidative-stability test

NASA Astrophysics Data System (ADS)

Shin, Dongwon; Han, Myungseong; Shul, Yong-Gun; Lee, Hyejin; Bae, Byungchan

2018-02-01

The oxidative stability of membranes constructed from a composite of pristine sulfonated poly(arylene ether sulfone) and cerium was investigated by conducting an accelerated oxidative-stability test at the open-circuit voltage (OCV). The membranes were analyzed in situ through OCV and impedance measurements, cyclic voltammetry, and linear-sweep voltammetry to monitor the electrochemical properties during the stability test. Although the high-frequency resistance of a composite membrane was slightly higher than that of a pristine membrane because of the exchange of protons from the sulfonic acid with cerium ions, the composite membrane maintained its potential for much longer than the pristine membrane. The effect of the cerium ions as radical scavengers was confirmed by analyzing the drain water and chemical structure after operation. These post-operation analyses confirmed that cerium ions improved the oxidative stability of the hydrocarbon-based polymer during fuel-cell operation. It is clear that the cerium-based radical scavengers prevented chemical degradation of the polymer membrane as well as the electrode in terms of hydrogen cross-over, polymer-chain scission, and the electrochemical surface area, while they rarely diffused outward from the membrane.

An ultrasonic-accelerated oxidation method for determining the oxidative stability of biodiesel.

PubMed

Avila Orozco, Francisco D; Sousa, Antonio C; Domini, Claudia E; Ugulino Araujo, Mario Cesar; Fernández Band, Beatriz S

2013-05-01

Biodiesel is considered an alternative energy because it is produced from fats and vegetable oils by means of transesterification. Furthermore, it consists of fatty acid alkyl esters (FAAS) which have a great influence on biodiesel fuel properties and in the storage lifetime of biodiesel itself. The biodiesel storage stability is directly related to the oxidative stability parameter (Induction Time - IT) which is determined by means of the Rancimat® method. This method uses condutimetric monitoring and induces the degradation of FAAS by heating the sample at a constant temperature. The European Committee for Standardization established a standard (EN 14214) to determine the oxidative stability of biodiesel, which requires it to reach a minimum induction period of 6h as tested by Rancimat® method at 110°C. In this research, we aimed at developing a fast and simple alternative method to determine the induction time (IT) based on the FAAS ultrasonic-accelerated oxidation. The sonodegradation of biodiesel samples was induced by means of an ultrasonic homogenizer fitted with an immersible horn at 480Watts of power and 20 duty cycles. The UV-Vis spectrometry was used to monitor the FAAS sonodegradation by measuring the absorbance at 270nm every 2. Biodiesel samples from different feedstock were studied in this work. In all cases, IT was established as the inflection point of the absorbance versus time curve. The induction time values of all biodiesel samples determined using the proposed method was in accordance with those measured through the Rancimat® reference method by showing a R(2)=0.998. Copyright © 2012 Elsevier B.V. All rights reserved.

Feasibility study of basic characterization of MAGAT polymer gel using CBCT attached in linear accelerator: Preliminary study

NASA Astrophysics Data System (ADS)

Sathiyaraj, P.; Samuel, E. James jebaseelan

2018-01-01

The aim of this study is to evaluate the methacrylic acid, gelatin and tetrakis (hydroxymethyl) phosphonium chloride gel (MAGAT) by cone beam computed tomography (CBCT) attached with modern linear accelerator. To compare the results of standard diagnostic computed tomography (CT) with CBCT, different parameters such as linearity, sensitivity and temporal stability were checked. MAGAT gel showed good linearity for both diagnostic CT and CBCT measurements. Sensitivity and temporal stability were also comparable with diagnostic CT measurements. In both the modalities, the sensitivity of the MAGAT increased to 4 days and decreased till the 10th day of post irradiation. Since all measurements (linearity, sensitivity and temporal stability) from diagnostic CT and CBCT were comparable, CBCT could be a potential tool for dose analysis study for polymer gel dosimeter.

Freeze-dried snake antivenoms formulated with sorbitol, sucrose or mannitol: comparison of their stability in an accelerated test.

PubMed

Herrera, María; Tattini, Virgilio; Pitombo, Ronaldo N M; Gutiérrez, José María; Borgognoni, Camila; Vega-Baudrit, José; Solera, Federico; Cerdas, Maykel; Segura, Alvaro; Villalta, Mauren; Vargas, Mariángela; León, Guillermo

2014-11-01

Freeze-drying is used to improve the long term stability of pharmaceutical proteins. Sugars and polyols have been successfully used in the stabilization of proteins. However, their use in the development of freeze-dried antivenoms has not been documented. In this work, whole IgG snake antivenom, purified from equine plasma, was formulated with different concentrations of sorbitol, sucrose or mannitol. The glass transition temperatures of frozen formulations, determined by Differential Scanning Calorimetry (DSC), ranged between -13.5 °C and -41 °C. In order to evaluate the effectiveness of the different stabilizers, the freeze-dried samples were subjected to an accelerated stability test at 40 ± 2 °C and 75 ± 5% relative humidity. After six months of storage at 40 °C, all the formulations presented the same residual humidity, but significant differences were observed in turbidity, reconstitution time and electrophoretic pattern. Moreover, all formulations, except antivenoms freeze-dried with mannitol, exhibited the same potency for the neutralization of lethal effect of Bothrops asper venom. The 5% (w:v) sucrose formulation exhibited the best stability among the samples tested, while mannitol and sorbitol formulations turned brown. These results suggest that sucrose is a better stabilizer than mannitol and sorbitol in the formulation of freeze-dried antivenoms under the studied conditions. Copyright © 2014 Elsevier Ltd. All rights reserved.

Color Stability of CAD/CAM Fabricated Inlays after Accelerated Artificial Aging.

PubMed

Karaokutan, Isil; Yilmaz Savas, Tuba; Aykent, Filiz; Ozdere, Eda

2016-08-01

To investigate the influence of accelerated artificial aging on the color stability of three different inlay restorations produced with a CAD/CAM system. Thirty non-carious human mandibular molar teeth were used. The teeth were embedded in autopolymerizing acrylic resin blocks. Standard Class I inlay cavities were prepared, and the teeth were randomly divided into three groups (n = 10) to fabricate inlay restorations: (1) a feldspathic-ceramic group, (2) a resin nano-ceramic group, and (3) a leucite glass-ceramic group. Optical impressions were made with CEREC software, and the restorations were designed and then milled. The inlays were adhesively cemented with a dual-polymerizing resin cement and left in distilled water at room temperature for 1 week. Color measurements were performed with a spectrophotometer before and after accelerated aging in a weathering machine with a total energy of 150 kJ/m(2) . Changes in color (∆E, ∆L, ∆a, ∆b, ∆C) were determined using the CIE L*a*b* system. The results were assessed using a one-way ANOVA and Tukey's HSD test (p = 0.05). The color changes of the materials ranged from 2.1 to 9.29. The highest color change was seen in the resin nano-ceramic material. This change was not clinically acceptable (∆E > 5.5). No significant differences were found in the ∆L and ∆a values of the test groups. Color changes were observed in each evaluated material after accelerated aging. All CAD/CAM inlays became darker in appearance, more saturated, a little reddish, and more yellow. © 2015 by the American College of Prosthodontists.

An optical fiber spool for laser stabilization with reduced acceleration sensitivity to 10-12/g

NASA Astrophysics Data System (ADS)

Hu, Yong-Qi; Dong, Jing; Huang, Jun-Chao; Li, Tang; Liu, Liang

2015-10-01

Environmental vibration causes mechanical deformation in optical fibers, which induces excess frequency noise in fiber-stabilized lasers. In order to solve such a problem, we propose an ultralow acceleration sensitivity fiber spool with symmetrically mounted structure. By numerical analysis with the finite element method, we obtain the optimal geometry parameters of the spool with which the horizontal and vertical acceleration sensitivity can be reduced to 3.25 × 10-12/g and 5.38 × 10-12/g respectively. Moreover, the structure features the insensitivity to the variation of geometry parameters, which will minimize the influence from numerical simulation error and manufacture tolerance. Project supported by the National Natural Science Foundation of China (Grant Nos. 11034008 and 11274324) and the Key Research Program of the Chinese Academy of Sciences (Grant No. KJZD-EW-W02).

Colour-stability and gloss-retention of silorane and dimethacrylate composites with accelerated aging.

PubMed

Furuse, Adilson Y; Gordon, Kathryn; Rodrigues, Flávia P; Silikas, Nick; Watts, David C

2008-11-01

To evaluate the colour-stability and gloss-retention of silorane versus dimethacrylate composites exposed to accelerated aging from daylight radiation. Five disc-shaped specimens of photo-cured resin-composites were prepared and manually polished for each material (Filtek Silorane, Herculite XRV, Tetric Evoceram and QuiXfil). Colour and gloss were evaluated before and after periods (baseline, 24, 72, 120 and 192 h) of accelerated photo-aging in xenon light following ISO 7491:2000. Colour measurements were performed with a colourimeter according to the CIE-Lab colour-space. The colour change (DeltaE) for each time was calculated. The surface gloss was measured using a glossmeter. Results were evaluated using one-way ANOVA and Tukey tests (alpha=0.05). Correlations between logtime, DeltaE and gloss were evaluated using Pearson's correlation (alpha=0.05). Materials generally decreased in L and a and increased in b. The strong exception was Filtek Silorane which maintained a and b. DeltaE was found to be a positive linear function of logtime for all materials. Materials varied in the magnitude and rate of increase of DeltaE with logtime: QuiXfil>Tetric EvoCeram>(Filtek Silorane>or=Herculite XRV). DeltaE remained<3.3 for Filtek Silorane and Herculite XRV. Gloss was found to be a negative linear function of logtime. Gloss was maximal in the sequence: Filtek Silorane approximately Tetric EvoCeram>Herculite XRV>QuiXfil. Silorane gave the best overall performance in stability over time, compared to a set of representative dimethacrylate composites.

A Numerical Study of Wind-Turbine Wakes for Three Atmospheric Stability Conditions

NASA Astrophysics Data System (ADS)

Xie, Shengbai; Archer, Cristina L.

2017-10-01

The effects of atmospheric stability on wind-turbine wakes are studied via large-eddy simulations. Three stability conditions are considered: stable, neutral, and unstable, with the same geostrophic wind speed aloft and the same Coriolis frequency. Both a single 5-MW turbine and a wind farm of five turbines are studied. The single-turbine wake is strongly correlated with stability, in terms of velocity deficit, turbulence kinetic energy (TKE) and temperature distribution. Because of the Coriolis effect, the wake shape deviates from a Gaussian distribution. For the wind-farm simulations, the separation of the core region and outer region is clear for the stable and neutral cases, but less distinct for the unstable case. The unstable case exhibits strong horizontal variations in wind speed. Local accelerations such as related to aisle jets are also observed, whose features depend on stability. The added TKE in the wind farm increases with stability. The highest power extraction and lowest power deficit are observed for the unstable case.

Box-Behnken study design for optimization of bicalutamide-loaded nanostructured lipid carrier: stability assessment.

PubMed

Kudarha, Ritu; Dhas, Namdev L; Pandey, Abhijeet; Belgamwar, Veena S; Ige, Pradum P

2015-01-01

Bicalutamide (BCM) is an anti-androgen drug used to treat prostate cancer. In this study, nanostructured lipid carriers (NLCs) were chosen as a carrier for delivery of BCM using Box-Behnken (BB) design for optimizing various quality attributes such as particle size and entrapment efficiency which is very critical for efficient drug delivery and high therapeutic efficacy. Stability of formulated NLCs was assessed with respect to storage stability, pH stability, hemolysis, protein stability, serum protein stability and accelerated stability. Hot high-pressure homogenizer was utilized for formulation of BCM-loaded NLCs. In BB response surface methodology, total lipid, % liquid lipid and % soya lecithin was selected as independent variable and particle size and %EE as dependent variables. Scanning electron microscopy (SEM) was done for morphological study of NLCs. Differential scanning calorimeter and X-ray diffraction study were used to study crystalline and amorphous behavior. Analysis of design space showed that process was robust with the particle size less than 200 nm and EE up to 78%. Results of stability studies showed stability of carrier in various storage conditions and in different pH condition. From all the above study, it can be concluded that NLCs may be suitable carrier for the delivery of BCM with respect to stability and quality attributes.

Fokker-Planck Equations of Stochastic Acceleration: A Study of Numerical Methods

NASA Astrophysics Data System (ADS)

Park, Brian T.; Petrosian, Vahe

1996-03-01

Stochastic wave-particle acceleration may be responsible for producing suprathermal particles in many astrophysical situations. The process can be described as a diffusion process through the Fokker-Planck equation. If the acceleration region is homogeneous and the scattering mean free path is much smaller than both the energy change mean free path and the size of the acceleration region, then the Fokker-Planck equation reduces to a simple form involving only the time and energy variables. in an earlier paper (Park & Petrosian 1995, hereafter Paper 1), we studied the analytic properties of the Fokker-Planck equation and found analytic solutions for some simple cases. In this paper, we study the numerical methods which must be used to solve more general forms of the equation. Two classes of numerical methods are finite difference methods and Monte Carlo simulations. We examine six finite difference methods, three fully implicit and three semi-implicit, and a stochastic simulation method which uses the exact correspondence between the Fokker-Planck equation and the it5 stochastic differential equation. As discussed in Paper I, Fokker-Planck equations derived under the above approximations are singular, causing problems with boundary conditions and numerical overflow and underflow. We evaluate each method using three sample equations to test its stability, accuracy, efficiency, and robustness for both time-dependent and steady state solutions. We conclude that the most robust finite difference method is the fully implicit Chang-Cooper method, with minor extensions to account for the escape and injection terms. Other methods suffer from stability and accuracy problems when dealing with some Fokker-Planck equations. The stochastic simulation method, although simple to implement, is susceptible to Poisson noise when insufficient test particles are used and is computationally very expensive compared to the finite difference method.

An extended macro model accounting for acceleration changes with memory and numerical tests

NASA Astrophysics Data System (ADS)

Cheng, Rongjun; Ge, Hongxia; Sun, Fengxin; Wang, Jufeng

2018-09-01

Considering effect of acceleration changes with memory, an improved continuum model of traffic flow is proposed in this paper. By applying the linear stability theory, we derived the new model's linear stability condition. Through nonlinear analysis, the KdV-Burgers equation is derived to describe the propagating behavior of traffic density wave near the neutral stability line. Numerical simulation is carried out to study the extended traffic flow model, which explores how acceleration changes with memory affected each car's velocity, density and fuel consumption and exhaust emissions. Numerical results demonstrate that acceleration changes with memory have significant negative effect on dynamic characteristic of traffic flow. Furthermore, research results verify that the effect of acceleration changes with memory will deteriorate the stability of traffic flow and increase cars' total fuel consumptions and emissions during the whole evolution of small perturbation.

Analytic model of a laser-accelerated composite plasma target and its stability

NASA Astrophysics Data System (ADS)

Khudik, Vladimir; Shvets, Gennady

2013-10-01

A self-consistent analytical model of monoenergetic acceleration of a one and two-species ultrathin target irradiated by a circularly polarized laser pulse is developed. In the accelerated reference frame, the bulk plasma in the target is neutral and its parameters are assumed to be stationary. It is found that the structure of the target depends strongly on the temperatures of electrons and ions, which are both strongly influenced by the laser pulse pedestal. When the electron temperature is large, the hot electrons bounce back and forth inside the potential well formed by ponderomotive and electrostatic potentials while the heavy and light ions are forced-balanced by the electrostatic and non-inertial fields forming two separated layers. In the opposite limiting case when the ion temperature is large, the hot ions are trapped in the potential well formed by the ion-sheath's electric and non-inertial potentials while the cold electrons are forced-balanced by the electrostatic and ponderomotive fields. Using PIC simulations we have determined which scenario is realized in practice depending on the initial target structure and laser intensity. Target stability with respect to Rayleigh-Taylor instability will also be discussed. This work is supported by the US DOE grants DE-FG02-04ER41321 and DE-FG02-07ER54945.

A strategy to accelerate protein production from a pool of clones in Chinese hamster ovary cells for toxicology studies.

PubMed

Hu, Zhilan; Hsu, Wendy; Pynn, Abby; Ng, Domingos; Quicho, Donna; Adem, Yilma; Kwong, Zephie; Mauger, Brad; Joly, John; Snedecor, Bradley; Laird, Michael W; Andersen, Dana C; Shen, Amy

2017-11-01

In the biopharmaceutical industry, a clonally derived cell line is typically used to generate material for investigational new drug (IND)-enabling toxicology studies. The same cell line is then used to generate material for clinical studies. If a pool of clones can be used to produce material for IND-enabling toxicology studies (Pool for Tox (PFT) strategy) during the time a lead clone is being selected for clinical material production, the toxicology studies can be accelerated significantly (approximately 4 months at Genentech), leading to a potential acceleration of 4 months for the IND submission. We explored the feasibility of the PFT strategy with three antibodies-mAb1, mAb2, and mAb3-at the 2 L scale. For each antibody, two lead cell lines were identified that generated material with similar product quality to the material generated from the associated pool. For two antibody molecules, mAb1 and mAb2, the material generated by the lead cell lines from 2 L bioreactors was tested in an accelerated stability study and was shown to have stability comparable to the material generated by the associated pool. Additionally, we used this approach for two antibody molecules, mAb4 and mAb5, at Tox and GMP production. The materials from the Tox batch at 400 L scale and three GMP batches at 2000 L scale have comparable product quality attributes for both molecules. Our results demonstrate the feasibility of using a pool of clonally derived cell lines to generate material of similar product quality and stability for use in IND-enabling toxicology studies as was derived from the final production clone, which enabled significant acceleration of timelines into clinical development. © 2017 American Institute of Chemical Engineers Biotechnol. Prog., 33:1449-1455, 2017. © 2017 American Institute of Chemical Engineers.

Evaluation of non-volatile metabolites in beer stored at high temperature and utility as an accelerated method to predict flavour stability.

PubMed

Heuberger, Adam L; Broeckling, Corey D; Sedin, Dana; Holbrook, Christian; Barr, Lindsay; Kirkpatrick, Kaylyn; Prenni, Jessica E

2016-06-01

Flavour stability is vital to the brewing industry as beer is often stored for an extended time under variable conditions. Developing an accelerated model to evaluate brewing techniques that affect flavour stability is an important area of research. Here, we performed metabolomics on non-volatile compounds in beer stored at 37 °C between 1 and 14 days for two beer types: an amber ale and an India pale ale. The experiment determined high temperature to influence non-volatile metabolites, including the purine 5-methylthioadenosine (5-MTA). In a second experiment, three brewing techniques were evaluated for improved flavour stability: use of antioxidant crowns, chelation of pro-oxidants, and varying plant content in hops. Sensory analysis determined the hop method was associated with improved flavour stability, and this was consistent with reduced 5-MTA at both regular and high temperature storage. Future studies are warranted to understand the influence of 5-MTA on flavour and aging within different beer types. Copyright © 2016 Elsevier Ltd. All rights reserved.

Accelerated stability and bioassay of a new oral α-ketoglutarate formulation for treating cyanide poisoning.

PubMed

Bhattacharya, Rahul; Gopalan, Natarajan; Singh, Anil Kumar; Singh, Poonam; Yadav, Shiv Kumar; Rao, Pooja; Shrivastava, Saurabh

2014-02-01

Due to several limitations of existing cyanide antidotes, α-ketoglutarate (α-KG) has been proposed as a promising treatment for cyanide. This study reports the accelerated stability and bioassay of a new oral α-KG formulation. Amber-colored PVDF bottles containing 100 ml of 10% α-KG in 70% sorbitol, preservative (sodium methyl paraben and sodium propyl paraben), sweetener (sodium saccharine), flavor (American ice-cream soda and peppermint) and color (tartrazine), at pH 7.0-8.0 were stored in stability chamber (40 ± 2 °C and 75 ± 5% humidity) for 6 months in a GMP compliant facility. Various physical (pH, color, evaporation, extractable volume and clarity), chemical (identification and quantification of active ingredient) and microbiological (total aerobic count) analyses, together with protection studies were carried periodically in mice. Acute toxicity of the formulation and bioavailability of α-KG were assessed in rats at the beginning of the experiment. No physical changes and microbiological growth were observed in the formulation. After 6 months, α-KG content in the formulation diminished by ∼24% but its protective efficacy against cyanide remained at 5.9-fold. Protection was further characterized spectrophotometrically by disappearance of α-KG spectrum in the presence of cyanide, confirming cyanohydrin formation. Oral LD50 of α-KG formulation in rats was >7.0 g/kg body weight, and did not produce any acute toxicity of clinical significance. Also, an appreciable amount of α-KG was measured in blood. As per the guidelines of International Conference on Harmonization, the new α-KG formulation exhibited satisfactory stability, bioefficacy and safety as cyanide antidote.

Theoretical and Experimental Studies in Accelerator Physics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rosenzweig, James

This report describes research supported by the US Dept. of Energy Office of High Energy Physics (OHEP), performed by the UCLA Particle Beam Physics Laboratory (PBPL). The UCLA PBPL has, over the last two decades-plus, played a critical role in the development of advanced accelerators, fundamental beam physics, and new applications enabled by these thrusts, such as new types of accelerator-based light sources. As the PBPL mission is broad it is natural that it has been grown within the context of the accelerator science and technology stewardship of the OHEP. Indeed, steady OHEP support for the program has always beenmore » central to the success of the PBPL; it has provided stability, and above all has set the over-arching themes for our research directions, which have producing over 500 publications (>120 in high level journals). While other agency support has grown notably in recent years, permitting more vigorous pursuit of the program, it is transient by comparison. Beyond permitting program growth in a time of flat OHEP budgets, the influence of other agency missions is found in push to adapt advanced accelerator methods to applications, in light of the success the field has had in proof-of-principle experiments supported first by the DoE OHEP. This three-pronged PBPL program — advanced accelerators, fundamental beam physics and technology, and revolutionary applications — has produced a generation of students that have had a profound affect on the US accelerator physics community. PBPL graduates, numbering 28 in total, form a significant population group in the accelerator community, playing key roles as university faculty, scientific leaders in national labs (two have been named Panofsky Fellows at SLAC), and vigorous proponents of industrial application of accelerators. Indeed, the development of advanced RF, optical and magnet technology at the PBPL has led directly to the spin-off company, RadiaBeam Technologies, now a leading industrial

Influence of artificial accelerated aging on dimensional stability of acrylic resins submitted to different storage protocols.

PubMed

Garcia, Lucas da Fonseca Roberti; Roselino, Lourenço de Moraes Rego; Mundim, Fabrício Mariano; Pires-de-Souza, Fernanda de Carvalho Panzeri; Consani, Simonides

2010-08-01

The aim of this study was to evaluate the influence of artificial accelerated aging on dimensional stability of two types of acrylic resins (thermally and chemically activated) submitted to different protocols of storage. One hundred specimens were made using a Teflon matrix (1.5 cm x 0.5 mm) with four imprint marks, following the lost-wax casting method. The specimens were divided into ten groups, according to the type of acrylic resin, aging procedure, and storage protocol (30 days). GI: acrylic resins thermally activated, aging, storage in artificial saliva for 16 hours, distilled water for 8 hours; GII: thermal, aging, artificial saliva for 16 hours, dry for 8 hours; GIII: thermal, no aging, artificial saliva for 16 hours, distilled water for 8 hours, GIV: thermal, no aging, artificial saliva for 16 hours, dry for 8 hours; GV: acrylic resins chemically activated, aging, artificial saliva for 16 hours, distilled water for 8 hours; GVI: chemical, aging, artificial saliva for 16 hours, dry for 8 hours; GVII: chemical, no aging, artificial saliva for 16 hours, distilled water for 8 hours; GVIII: chemical, no aging, artificial saliva for 16 hours, dry for 8 hours GIX: thermal, dry for 24 hours; and GX: chemical, dry for 24 hours. All specimens were photographed before and after treatment, and the images were evaluated by software (UTHSCSA - Image Tool) that made distance measurements between the marks in the specimens (mm), calculating the dimensional stability. Data were submitted to statistical analysis (two-way ANOVA, Tukey test, p= 0.05). Statistical analysis showed that the specimens submitted to storage in water presented the largest distance between both axes (major and minor), statistically different (p < 0.05) from control groups. All acrylic resins presented dimensional changes, and the artificial accelerated aging and storage period influenced these alterations.

Beam manipulation for resonant plasma wakefield acceleration

NASA Astrophysics Data System (ADS)

Chiadroni, E.; Alesini, D.; Anania, M. P.; Bacci, A.; Bellaveglia, M.; Biagioni, A.; Bisesto, F. G.; Cardelli, F.; Castorina, G.; Cianchi, A.; Croia, M.; Gallo, A.; Di Giovenale, D.; Di Pirro, G.; Ferrario, M.; Filippi, F.; Giribono, A.; Marocchino, A.; Mostacci, A.; Petrarca, M.; Piersanti, L.; Pioli, S.; Pompili, R.; Romeo, S.; Rossi, A. R.; Scifo, J.; Shpakov, V.; Spataro, B.; Stella, A.; Vaccarezza, C.; Villa, F.

2017-09-01

Plasma-based acceleration has already proved the ability to reach ultra-high accelerating gradients. However the step towards the realization of a plasma-based accelerator still requires some effort to guarantee high brightness beams, stability and reliability. A significant improvement in the efficiency of PWFA has been demonstrated so far accelerating a witness bunch in the wake of a higher charge driver bunch. The transformer ratio, therefore the energy transfer from the driver to the witness beam, can be increased by resonantly exciting the plasma with a properly pre-shaped drive electron beam. Theoretical and experimental studies of beam manipulation for resonant PWFA will be presented here.

Improvements to laser wakefield accelerated electron beam stability, divergence, and energy spread using three-dimensional printed two-stage gas cell targets

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vargas, M.; Schumaker, W.; He, Z.-H.

2014-04-28

High intensity, short pulse lasers can be used to accelerate electrons to ultra-relativistic energies via laser wakefield acceleration (LWFA) [T. Tajima and J. M. Dawson, Phys. Rev. Lett. 43, 267 (1979)]. Recently, it was shown that separating the injection and acceleration processes into two distinct stages could prove beneficial in obtaining stable, high energy electron beams [Gonsalves et al., Nat. Phys. 7, 862 (2011); Liu et al., Phys. Rev. Lett. 107, 035001 (2011); Pollock et al., Phys. Rev. Lett. 107, 045001 (2011)]. Here, we use a stereolithography based 3D printer to produce two-stage gas targets for LWFA experiments on themore » HERCULES laser system at the University of Michigan. We demonstrate substantial improvements to the divergence, pointing stability, and energy spread of a laser wakefield accelerated electron beam compared with a single-stage gas cell or gas jet target.« less

Nonlinear dynamics of autonomous vehicles with limits on acceleration

NASA Astrophysics Data System (ADS)

Davis, L. C.

2014-07-01

The stability of autonomous vehicle platoons with limits on acceleration and deceleration is determined. If the leading-vehicle acceleration remains within the limits, all vehicles in the platoon remain within the limits when the relative-velocity feedback coefficient is equal to the headway time constant [k=1/h]. Furthermore, if the sensitivity α>1/h, no collisions occur. String stability for small perturbations is assumed and the initial condition is taken as the equilibrium state. Other values of k and α that give stability with no collisions are found from simulations. For vehicles with non-negligible mechanical response, simulations indicate that the acceleration-feedback-control gain might have to be dynamically adjusted to obtain optimal performance as the response time changes with engine speed. Stability is demonstrated for some perturbations that cause initial acceleration or deceleration greater than the limits, yet do not cause collisions.

A TE-mode accelerator

NASA Astrophysics Data System (ADS)

Takeuchi, S.; Sakai, K.; Matsumoto, M.; Sugihara, R.

1987-04-01

An accelerator is proposed in which a TE-mode wave is used to drive charged particles in contrast to the usual linear accelerators in which longitudinal electric fields or TM-mode waves are supposed to be utilized. The principle of the acceleration is based on the V(p) x B acceleration of a dynamo force acceleration, in which a charged particle trapped in a transverse wave feels a constant electric field (Faraday induction field) and subsequently is accelerated when an appropriate magnetic field is externally applied in the direction perpendicular to the wave propagation. A pair of dielectric plates is used to produce a slow TE mode. The conditions of the particle trapping the stabilization of the particle orbit are discussed.

Basic principles of stability.

PubMed

Egan, William; Schofield, Timothy

2009-11-01

An understanding of the principles of degradation, as well as the statistical tools for measuring product stability, is essential to management of product quality. Key to this is management of vaccine potency. Vaccine shelf life is best managed through determination of a minimum potency release requirement, which helps assure adequate potency throughout expiry. Use of statistical tools such a least squares regression analysis should be employed to model potency decay. The use of such tools provides incentive to properly design vaccine stability studies, while holding stability measurements to specification presents a disincentive for collecting valuable data. The laws of kinetics such as Arrhenius behavior help practitioners design effective accelerated stability programs, which can be utilized to manage stability after a process change. Design of stability studies should be carefully considered, with an eye to minimizing the variability of the stability parameter. In the case of measuring the degradation rate, testing at the beginning and the end of the study improves the precision of this estimate. Additional design considerations such as bracketing and matrixing improve the efficiency of stability evaluation of vaccines.

[Studies of local anaesthetics: part 205* studies of stability of heptacainium chloride and carbisocainium chloride using an accelerated non-isothermal test].

PubMed

Stankovičová, Mária; Lašáková, Andrea; Medlenová, Veronika; Bezáková, Zelmíra; Cižmárik, Jozef

2014-08-01

The paper studies the kinetics of alkaline hydrolysis and stability under non-isothermal conditions of heptacainium chloride and carbisocainium chloride in the medium of aqueous-ethanolic solution of sodium hydroxide c = 0.1 mol/l and buffer solutions of values of pH 7.0 and pH 8.0. The results of the study of the kinetics of hydrolysis by means of a non-isothermal test - rate constants and activation energy values served as the basis for exact evaluation of the stability of these potential pharmaceuticals. The objective of the paper links up with the previous studies of these substances.

Modification of the argon stripping target of the tandem accelerator.

PubMed

Makarov, A; Ostreinov, Yu; Taskaev, S; Vobly, P

2015-12-01

The tandem accelerator with vacuum insulation has been proposed and developed in Budker Institute of Nuclear Physics. Negative hydrogen ions are accelerated by the positive 1MV potential of the high-voltage electrode, converted into protons in the gas stripping target inside the electrode, and then protons are accelerated again by the same potential. A stationary proton beam with 2 MeV energy, 1.6 mA current, 0.1% energy monochromaticity, and 0.5% current stability is obtained now. To conduct Boron Neutron Capture Therapy it is planned to increase the proton beam current to at least 3 mA. The paper presents the results of experimental studies clarifying the reasons for limiting the current, and gives suggestions for modifying the gas stripping target in order to increase the proton beam current along with the stability of the accelerator. Copyright © 2015 Elsevier Ltd. All rights reserved.

Thermodynamics of Accelerating Black Holes.

PubMed

Appels, Michael; Gregory, Ruth; Kubizňák, David

2016-09-23

We address a long-standing problem of describing the thermodynamics of an accelerating black hole. We derive a standard first law of black hole thermodynamics, with the usual identification of entropy proportional to the area of the event horizon-even though the event horizon contains a conical singularity. This result not only extends the applicability of black hole thermodynamics to realms previously not anticipated, it also opens a possibility for studying novel properties of an important class of exact radiative solutions of Einstein equations describing accelerated objects. We discuss the thermodynamic volume, stability, and phase structure of these black holes.

Advances in simultaneous DSC-FTIR microspectroscopy for rapid solid-state chemical stability studies: some dipeptide drugs as examples.

PubMed

Lin, Shan-Yang; Wang, Shun-Li

2012-04-01

The solid-state chemistry of drugs has seen growing importance in the pharmaceutical industry for the development of useful API (active pharmaceutical ingredients) of drugs and stable dosage forms. The stability of drugs in various solid dosage forms is an important issue because solid dosage forms are the most common pharmaceutical formulation in clinical use. In solid-state stability studies of drugs, an ideal accelerated method must not only be selected by different complicated methods, but must also detect the formation of degraded product. In this review article, an analytical technique combining differential scanning calorimetry and Fourier-transform infrared (DSC-FTIR) microspectroscopy simulates the accelerated stability test, and simultaneously detects the decomposed products in real time. The pharmaceutical dipeptides aspartame hemihydrate, lisinopril dihydrate, and enalapril maleate either with or without Eudragit E were used as testing examples. This one-step simultaneous DSC-FTIR technique for real-time detection of diketopiperazine (DKP) directly evidenced the dehydration process and DKP formation as an impurity common in pharmaceutical dipeptides. DKP formation in various dipeptides determined by different analytical methods had been collected and compiled. Although many analytical methods have been applied, the combined DSC-FTIR technique is an easy and fast analytical method which not only can simulate the accelerated drug stability testing but also at the same time enable to explore phase transformation as well as degradation due to thermal-related reactions. This technique offers quick and proper interpretations. Copyright © 2012 Elsevier B.V. All rights reserved.

ION-STABILIZED ELECTRON INDUCTION ACCELERATOR

DOEpatents

Finkelstein, D.

1960-03-22

A method and apparatus for establishing an ion-stabilized self-focusing relativistic electron beam from a plasma are reported. A plasma is introduced into a specially designed cavity by plasma guns, and a magnetic field satisfying betatron conditions is produced in the cavity by currents flowing in the highly conductive, non-magnetic surface of the cavity. This field forms the electron beam by induction from the plasma.

Amps particle accelerator definition study

NASA Technical Reports Server (NTRS)

Sellen, J. M., Jr.

1975-01-01

The Particle Accelerator System of the AMPS (Atmospheric, Magnetospheric, and Plasmas in Space) payload is a series of charged particle accelerators to be flown with the Space Transportation System Shuttle on Spacelab missions. In the configuration presented, the total particle accelerator system consists of an energetic electron beam, an energetic ion accelerator, and both low voltage and high voltage plasma acceleration devices. The Orbiter is illustrated with such a particle accelerator system.

A comparison of biophysical characterization techniques in predicting monoclonal antibody stability.

PubMed

Thiagarajan, Geetha; Semple, Andrew; James, Jose K; Cheung, Jason K; Shameem, Mohammed

2016-01-01

With the rapid growth of biopharmaceutical product development, knowledge of therapeutic protein stability has become increasingly important. We evaluated assays that measure solution-mediated interactions and key molecular characteristics of 9 formulated monoclonal antibody (mAb) therapeutics, to predict their stability behavior. Colloidal interactions, self-association propensity and conformational stability were measured using effective surface charge via zeta potential, diffusion interaction parameter (kD) and differential scanning calorimetry (DSC), respectively. The molecular features of all 9 mAbs were compared to their stability at accelerated (25°C and 40°C) and long-term storage conditions (2-8°C) as measured by size exclusion chromatography. At accelerated storage conditions, the majority of the mAbs in this study degraded via fragmentation rather than aggregation. Our results show that colloidal stability, self-association propensity and conformational characteristics (exposed tryptophan) provide reasonable prediction of accelerated stability, with limited predictive value at 2-8°C stability. While no correlations to stability behavior were observed with onset-of-melting temperatures or domain unfolding temperatures, by DSC, melting of the Fab domain with the CH2 domain suggests lower stability at stressed conditions. The relevance of identifying appropriate biophysical assays based on the primary degradation pathways is discussed.

Experimental demonstration of the stabilizing effect of dielectric coatings on magnetically accelerated imploding metallic liners

DOE Office of Scientific and Technical Information (OSTI.GOV)

Awe, Thomas James; Peterson, Kyle J.; Yu, Edmund P.

Enhanced implosion stability has been experimentally demonstrated for magnetically accelerated liners that are coated with 70 μm of dielectric. The dielectric tamps liner-mass redistribution from electrothermal instabilities and also buffers coupling of the drive magnetic field to the magneto-Rayleigh-Taylor instability. A dielectric-coated and axially premagnetized beryllium liner was radiographed at a convergence ratio [CR=R in,0/R in(z,t)] of 20, which is the highest CR ever directly observed for a strengthless magnetically driven liner. Lastly, the inner-wall radius R in(z,t) displayed unprecedented uniformity, varying from 95 to 130 μm over the 4.0 mm axial height captured by the radiograph.

Experimental demonstration of the stabilizing effect of dielectric coatings on magnetically accelerated imploding metallic liners

DOE PAGES

Awe, Thomas James; Peterson, Kyle J.; Yu, Edmund P.; ...

2016-02-10

Enhanced implosion stability has been experimentally demonstrated for magnetically accelerated liners that are coated with 70 μm of dielectric. The dielectric tamps liner-mass redistribution from electrothermal instabilities and also buffers coupling of the drive magnetic field to the magneto-Rayleigh-Taylor instability. A dielectric-coated and axially premagnetized beryllium liner was radiographed at a convergence ratio [CR=R in,0/R in(z,t)] of 20, which is the highest CR ever directly observed for a strengthless magnetically driven liner. Lastly, the inner-wall radius R in(z,t) displayed unprecedented uniformity, varying from 95 to 130 μm over the 4.0 mm axial height captured by the radiograph.

Dynamic stabilization of Rayleigh-Taylor instability in an ablation front

DOE Office of Scientific and Technical Information (OSTI.GOV)

Piriz, A. R.; Di Lucchio, L.; Rodriguez Prieto, G.

2011-01-15

Dynamic stabilization of Rayleigh-Taylor instability in an ablation front is studied by considering a modulation in the acceleration that consists of sequences of Dirac deltas. This allows obtaining explicit analytical expressions for the instability growth rate as well as for the boundaries of the stability region. As a general rule, it is found that it is possible to stabilize all wave numbers above a certain minimum value k{sub m}, but the requirements in the modulation amplitude and frequency become more exigent with smaller k{sub m}. The essential role of compressibility is phenomenologically addressed in order to find the constraint itmore » imposes on the stability region. The results for some different wave forms of the acceleration modulation are also presented.« less

Stability studies of anticancer agent bis(4-fluorobenzyl)trisulfide and synthesis of related substances.

PubMed

Bao, Yimei; Mo, Xiaopeng; Xu, Xiaoying; He, Yuyu; Xu, Xiao; An, Haoyun

2008-11-04

Bis(4-fluorobenzyl)trisulfide, fluorapacin, has been extensively developed as a promising new anticancer drug candidate. Its degradation products were identified and verified by the newly synthesized compounds bis(4-fluorobenzyl)disulfide (A) and bis(4-fluorobenzyl)tetrasulfide (B) which were resulted from the disproportionation of fluorapacin under forced conditions. A stability-indicating HPLC method was used for the stability evaluation of active pharmaceutical ingredient (API) fluorapacin and finished pharmaceutical product (FPP) under various conditions. High recovery (99.57%) of API was found after three freeze-thaw cycle processes of fluorapacin FPP. Susceptibility of fluorapacin to oxidative degradation was studied by treating fluorapacin and FPP in 30% hydrogen peroxide aqueous solution, and the result verified the oxidative stability of fluorapacin. However, treatment of this drug candidate under strong light (4500 Lx+/-500 Lx) for 10 days showed substantial effect on the recovery of fluorapacin, especially from fluorapacin FPP. Strong acid (1.0M, HCl) did not affect the recovery of fluorapacin while strong basic condition (1.0M, NaOH) accelerated the disproportionation of fluorapacin to its related substances A and B. The stability of fluorapacin in its aqueous media at a pH range of 2.0-10.0 for up to 6h was further investigated, and 4.0-8.0 was found to be the most stable pH range. Fluorapacin and FPP were exposed to the elevated temperatures of 40 and 60 degrees C for 10 days without obvious impact on their stability. The thermal stability of fluorapacin API and FPP under constant humidity with light protection was also thoroughly investigated under accelerated (40+/-2 degrees C, RH 75+/-5%, 6 months) and long-term (25+/-2 degrees C, RH 60+/-10%, 24 months) conditions. There was no significant change except minor color change of fluorapacin FPP. Therefore, fluorapacin has excellent stability as a potential drug candidate for further clinical

Advanced Accelerators for Medical Applications

NASA Astrophysics Data System (ADS)

Uesaka, Mitsuru; Koyama, Kazuyoshi

We review advanced accelerators for medical applications with respect to the following key technologies: (i) higher RF electron linear accelerator (hereafter “linac”); (ii) optimization of alignment for the proton linac, cyclotron and synchrotron; (iii) superconducting magnet; (iv) laser technology. Advanced accelerators for medical applications are categorized into two groups. The first group consists of compact medical linacs with high RF, cyclotrons and synchrotrons downsized by optimization of alignment and superconducting magnets. The second group comprises laser-based acceleration systems aimed of medical applications in the future. Laser plasma electron/ion accelerating systems for cancer therapy and laser dielectric accelerating systems for radiation biology are mentioned. Since the second group has important potential for a compact system, the current status of the established energy and intensity and of the required stability are given.

Advanced Accelerators for Medical Applications

NASA Astrophysics Data System (ADS)

Uesaka, Mitsuru; Koyama, Kazuyoshi

We review advanced accelerators for medical applications with respect to the following key technologies: (i) higher RF electron linear accelerator (hereafter "linac"); (ii) optimization of alignment for the proton linac, cyclotron and synchrotron; (iii) superconducting magnet; (iv) laser technology. Advanced accelerators for medical applications are categorized into two groups. The first group consists of compact medical linacs with high RF, cyclotrons and synchrotrons downsized by optimization of alignment and superconducting magnets. The second group comprises laserbased acceleration systems aimed of medical applications in the future. Laser plasma electron/ion accelerating systems for cancer therapy and laser dielectric accelerating systems for radiation biology are mentioned. Since the second group has important potential for a compact system, the current status of the established energy and intensity and of the required stability are given.

Stability versus Maneuvering: Challenges for Stability during Swimming by Fishes.

PubMed

Webb, Paul W; Weihs, Daniel

2015-10-01

Fishes are well known for their remarkable maneuverability and agility. Less visible is the continuous control of stability essential for the exploitation of the full range of aquatic resources. Perturbations to posture and trajectory arise from hydrostatic and hydrodynamic forces centered in a fish (intrinsic) and from the environment (extrinsic). Hydrostatic instabilities arise from vertical and horizontal separation of the centers of mass (CM) and of buoyancy, thereby creating perturbations in roll, yaw, and pitch, with largely neglected implications for behavioral ecology. Among various forms of hydrodynamic stability, the need for stability in the face of recoil forces from propulsors is close to universal. Destabilizing torques in body-caudal fin swimming is created by inertial and viscous forces through a propulsor beat. The recoil component is reduced, damped, and corrected in various ways, including kinematics, shape of the body and fins, and deployment of the fins. We postulate that control of the angle of orientation, θ, of the trailing edge is especially important in the evolution and lifestyles of fishes, but studies are few. Control of stability and maneuvering are reflected in accelerations around the CM. Accelerations for such motions may give insight into time-behavior patterns in the wild but cannot be used to determine the expenditure of energy by free-swimming fishes. © The Author 2015. Published by Oxford University Press on behalf of the Society for Integrative and Comparative Biology. All rights reserved. For permissions please email: journals.permissions@oup.com.

Electrostatic accelerators with high energy resolution

NASA Astrophysics Data System (ADS)

Uchiyama, T.; Agawa, Y.; Nishihashi, T.; Takagi, K.; Yamakawa, H.; Isoya, A.; Takai, M.; Namba, S.

1991-05-01

Several models of electrostatic accelerators based on rotating disks (Disktron) have been manufactured for various ion beam applications like surface analyses and implantation. The high voltage terminal of the Disktron with a terminal voltage of up to 500 kV is open in air, while the generator part is enclosed in FRP (fiber reinforced plastics) or a ceramic vessel filled with sf 6 gas. The 1 MV model is completely enclosed in a steel vessel. A compact tandem accelerator of the pellet chain type with a terminal voltage of 1.5 MV has also been manufactured. The good energy stability of these accelerators, typically in the range of 10 -4, has proved to be quite favorable for applications in precise studies of material surfaces, including the use of microbeam techniques.

Electrochemical stability and postmortem studies of Pt/SiC catalysts for polymer electrolyte membrane fuel cells.

PubMed

Stamatin, Serban N; Speder, Jozsef; Dhiman, Rajnish; Arenz, Matthias; Skou, Eivind M

2015-03-25

In the presented work, the electrochemical stability of platinized silicon carbide is studied. Postmortem transmission electron microscopy and X-ray photoelectron spectroscopy were used to document the change in the morphology and structure upon potential cycling of Pt/SiC catalysts. Two different potential cycle aging tests were used in order to accelerate the support corrosion, simulating start-up/shutdown and load cycling. On the basis of the results, we draw two main conclusions. First, platinized silicon carbide exhibits improved electrochemical stability over platinized active carbons. Second, silicon carbide undergoes at least mild oxidation if not even silicon leaching.

Development of Acceleration Sensor and Acceleration Evaluation System for Super-Low-Range Frequencies

NASA Astrophysics Data System (ADS)

Asano, Shogo; Matsumoto, Hideki

2001-05-01

This paper describes the development process for acceleration sensors used on automobiles and an acceleration evaluation system designed specifically for acceleration at super-low-range frequencies. The features of the newly developed sensor are as follows. 1) Original piezo-bimorph design based on a disc-center-fixed structure achieves pyroeffect cancelling and stabilization of sensor characteristics and enables the detection of the acceleration of 0.0009 G at the super-low-range-frequency of 0.03 Hz. 2) The addition of a self-diagnostic function utilizing the characteristics of piezoceramics enables constant monitoring of sensor failure. The frequency range of acceleration for accurate vehicle motion control is considered to be from DC to about 50 Hz. However, the measurement of acceleration in the super-low-range frequency near DC has been difficult because of mechanical and electrical noise interruption. This has delayed the development of the acceleration sensor for automotive use. We have succeeded in the development of an acceleration evaluation system for super-low-range frequencies from 0.015 Hz to 2 Hz with detection of the acceleration range from 0.0002 G (0.2 gal) to 1 G, as well as the development of a piezoelectric-type acceleration sensor for automotive use.

Testing of a Loop Heat Pipe Subjective to Variable Accelerations. Part 2; Temperature Stability

NASA Technical Reports Server (NTRS)

Ku, Jentung; Ottenstein, Laura; Kaya, Taril; Rogers, Paul; Hoff, Craig

2000-01-01

The effect of accelerating forces on the performance of loop heat pipes (LHP) is of interest and importance to terrestrial and space applications. LHP's are being considered for cooling of military combat vehicles and for spinning spacecraft. In order to investigate the effect of an accelerating force on LHP operation, a miniature LHP was installed on a spin table. Variable accelerating forces were imposed on the LHP by spinning the table at different angular speeds. Several patterns of accelerating forces were applied, i.e. continuous spin at different speeds and periodic spin at different speeds and frequencies. The resulting accelerations ranged from 1.17 g's to 4.7 g's. This paper presents the second part of the experimental study, i.e. the effect of an accelerating force on the LHP operating temperature. It has been known that in stationary tests the LHP operating temperature is a function of the evaporator power and the condenser sink temperature when the compensation temperature is not actively controlled. Results of this test program indicate that any change in the accelerating force will result in a chance in the LHP operating temperature through its influence on the fluid distribution in the evaporator, condenser and compensation chamber. However, the effect is not universal, rather it is a function of other test conditions. A steady, constant acceleration may result in an increase or decrease of the operating temperature, while a periodic spin will lead to a quasi-steady operating temperature over a sufficient time interval. In addition, an accelerating force may lead to temperature hysteresis and changes in the temperature oscillation. In spite of all these effects, the LHP continued to operate without any problems in all tests.

Accelerated decay rates drive soil organic matter persistence and storage in temperate forests via greater mineral stabilization of microbial residues.

NASA Astrophysics Data System (ADS)

Phillips, R.; Craig, M.; Turner, B. L.; Liang, C.

2017-12-01

Climate predicts soil organic matter (SOM) stocks at the global scale, yet controls on SOM stocks at finer spatial scales are still debated. A current hypothesis predicts that carbon (C) and nitrogen (N) storage in soils should be greater when decomposition is slow owing to microbial competition for nutrients or the recalcitrance of organic substrates (hereafter the `slow decay' hypothesis). An alternative hypothesis predicts that soil C and N storage should be greater in soils with rapid decomposition, owing to the accelerated production of microbial residues and their stabilization on soil minerals (hereafter the `stabilization hypothesis'). To test these alternative hypotheses, we quantified soil C and N to 1-m depth in temperate forests across the Eastern and Midwestern US that varied in their biotic, climatic, and edaphic properties. At each site, we sampled (1) soils dominated by arbuscular mycorrhizal (AM) tree species, which typically have fast decay rates and accelerated N cycling, (2) soils dominated by ectomycorrhizal (ECM) tree species, which generally have slow decay rates and slow N cycling, and (3) soils supporting both AM and ECM trees. To the extent that trees and theor associated microbes reflect and reinforce soil conditions, support for the slow decay hypothesis would be greater SOM storage in ECM soils, whereas support for the stabilization hypothesis would be greater SOM storage in AM soils. We found support for both hypotheses, as slow decomposition in ECM soils increased C and N storage in topsoil, whereas fast decomposition in AM soils increased C and N storage in subsoil. However, at all sites we found 57% greater total C and N storage in the entire profile in AM- soils (P < 0.0001), supporting the stabilization hypothesis. Amino sugar biomarkers (an indicator of microbial necromass) and particle size fractionation revealed that the greater SOM storage in AM soils was driven by an accumulation of microbial residues on clay minerals and

Formulation, physicochemical characterization and stability study of lithium-loaded microemulsion system.

PubMed

Mouri, Abdelkader; Legrand, Philippe; El Ghzaoui, Abdeslam; Dorandeu, Christophe; Maurel, Jean Claude; Devoisselle, Jean-Marie

2016-04-11

Lithium biocompatible microemulsion based on Peceol(®), lecithin, ethanol and water was studied in attempt to identify the optimal compositions in term of drug content, physicochemical properties and stability. Lithium solubilization in microemulsion was found to be compatible with a drug-surfactant binding model. Lithium ions were predominantly solubilized within lecithin head group altering significantly the interfacial properties of the system. Pseudo-ternary phase diagrams of drug free and drug loaded microemulsions were built at constant ethanol/lecithin weight ratio (40/60). Lithium loaded microemulsion has totally disappeared in the Peceol(®) rich part of phase diagram; critical fractions of lecithin and ethanol were required for the formation of stable microemulsion. The effect of lithium concentration on the properties and physical stability of microemulsions were studied using microscopy, Karl Fischer titrations, rheology analyses, conductivity measurements and centrifugation tests. The investigated microemulsions were found to be stable under accelerated storage conditions. The systems exhibited low viscosity and behaved as Newtonian fluid and no structural transition was shown. Copyright © 2016 Elsevier B.V. All rights reserved.

Acceleration of polarized protons and deuterons in the ion collider ring of JLEIC

NASA Astrophysics Data System (ADS)

Kondratenko, A. M.; Kondratenko, M. A.; Filatov, Yu N.; Derbenev, Ya S.; Lin, F.; Morozov, V. S.; Zhang, Y.

2017-07-01

The figure-8-shaped ion collider ring of Jefferson Lab Electron-Ion Collider (JLEIC) is transparent to the spin. It allows one to preserve proton and deuteron polarizations using weak stabilizing solenoids when accelerating the beam up to 100 GeV/c. When the stabilizing solenoids are introduced into the collider’s lattice, the particle spins precess about a spin field, which consists of the field induced by the stabilizing solenoids and the zero-integer spin resonance strength. During acceleration of the beam, the induced spin field is maintained constant while the resonance strength experiences significant changes in the regions of “interference peaks”. The beam polarization depends on the field ramp rate of the arc magnets. Its component along the spin field is preserved if acceleration is adiabatic. We present the results of our theoretical analysis and numerical modeling of the spin dynamics during acceleration of protons and deuterons in the JLEIC ion collider ring. We demonstrate high stability of the deuteron polarization in figure-8 accelerators. We analyze a change in the beam polarization when crossing the transition energy.

Influence of opacifiers on dimensional stability and detail reproduction of maxillofacial silicone elastomer

PubMed Central

2010-01-01

Background We evaluated the influence of chemical disinfection and accelerated aging on the dimensional stability and detail reproduction of a silicone elastomer containing one of two opacifiers. Methods A total of 90 samples were fabricated from Silastic MDX 4-4210 silicone and divided into groups (n = 10) according to opacifier content (barium sulfate or titanium dioxide) and disinfectant solution (neutral soap, Efferdent, or 4% chlorhexidine). The specimens were disinfected 3 times per week during 60 days and then subjected to accelerated aging for 1008 hours. Dimensional stability and detail reproduction tests were performed after specimens' fabrication (baseline), chemical disinfection and periodically during accelerated aging (252, 504, and 1008 hours). The results were analyzed using 3-way repeated-measures ANOVA and the Tukey HSD test (α = 0.05). Results All groups exhibited dimensional changes over time. The opacifier (p = .314), period (p < .0001) and their interactions (p = .0041) affected the dimensional stability of the silicone. Statistical significant dimensional differences occurred between groups with (0.071) and without opacifiers (0.053). Accelerated aging influenced the dimensional stability of the samples. All groups scored 2 in the detail reproduction tests, which represents the fully reproducing of three test grooves with accurate angles. Conclusions Incorporation of opacifiers alters the dimensional stability of silicones used in facial prosthetics, but seems to have no influence on detail reproduction. Accelerated aging is responsible for most of the dimensional changes in Silastic MDX4 4210, but all dimensional changes measured in this study remained within the limits of stability necessary for this application. PMID:21162729

The effect of accelerated aging on the wear of UHMWPE.

PubMed

Sakoda, H; Fisher, J; Lu, S; Buchanan, F

2001-01-01

Oxidative degradation of UHMWPE has been found to be a cause of elevated wear rate of the polymer in total joint replacement leading to failure of these devices. In order to evaluate long term stability of polymers, various accelerated aging methods have been developed. In this study, wear rates of shelf aged UHMWPE and "accelerated aged" UHMWPE were compared using a multi-directional pin-on-plate wear test machine in order to evaluate the effect of the accelerated aging on wear. Wear factors of the aged materials were found to depend on their density, which is a measure of oxidation level. Finally, accelerated aging was calibrated against shelf aging in terms of wear rate. Copyright 2001 Kluwer Academic Publishers

Efficient stabilization and acceleration of numerical simulation of fluid flows by residual recombination

NASA Astrophysics Data System (ADS)

Citro, V.; Luchini, P.; Giannetti, F.; Auteri, F.

2017-09-01

The study of the stability of a dynamical system described by a set of partial differential equations (PDEs) requires the computation of unstable states as the control parameter exceeds its critical threshold. Unfortunately, the discretization of the governing equations, especially for fluid dynamic applications, often leads to very large discrete systems. As a consequence, matrix based methods, like for example the Newton-Raphson algorithm coupled with a direct inversion of the Jacobian matrix, lead to computational costs too large in terms of both memory and execution time. We present a novel iterative algorithm, inspired by Krylov-subspace methods, which is able to compute unstable steady states and/or accelerate the convergence to stable configurations. Our new algorithm is based on the minimization of the residual norm at each iteration step with a projection basis updated at each iteration rather than at periodic restarts like in the classical GMRES method. The algorithm is able to stabilize any dynamical system without increasing the computational time of the original numerical procedure used to solve the governing equations. Moreover, it can be easily inserted into a pre-existing relaxation (integration) procedure with a call to a single black-box subroutine. The procedure is discussed for problems of different sizes, ranging from a small two-dimensional system to a large three-dimensional problem involving the Navier-Stokes equations. We show that the proposed algorithm is able to improve the convergence of existing iterative schemes. In particular, the procedure is applied to the subcritical flow inside a lid-driven cavity. We also discuss the application of Boostconv to compute the unstable steady flow past a fixed circular cylinder (2D) and boundary-layer flow over a hemispherical roughness element (3D) for supercritical values of the Reynolds number. We show that Boostconv can be used effectively with any spatial discretization, be it a finite

Klynac: Compact Linear Accelerator with Integrated Power Supply

NASA Astrophysics Data System (ADS)

Malyzhenkov, A. V.

Accelerators and accelerator-based light sources have a wide range of applications in science, engineering technology and medicine. Today the scientific community is working towards improving the quality of the accelerated beam and its parameters, while trying to develop technology for reducing accelerator size. This work describes a design of a compact linear accelerator (linac) prototype: resonant Klynac device, which is a combined linear accelerator and its power supply - klystron. The intended purpose of a Klynac device is to provide a compact and inexpensive alternative to a conventional 1 to 6 MeV accelerator, which typically requires a separate RF source, accelerator itself and all the associated hardware. Because the Klynac is a single structure, it has the potential to be much less sensitive to temperature variations than a system with separate klystron and linac. We start by introducing a simplified theoretical model for a Klynac device. We then demonstrate how a prototype is designed step-by-step using Particle-In-Cell simulation studies for mono-resonant and bi-resonant structures. Finally, we discuss design options from a stability point of view and required input power as well as behavior of competing modes for the actual built device.

Stabilized radio-frequency quadrupole

DOEpatents

Lancaster, H.D.; Fugitt, J.A.; Howard, D.R.

1982-09-29

A long-vane stabilized radio frequency resonator for accelerating charged particles and including means defining a radio frequency resonator cavity, a plurality of long vanes mounted in the defining means for dividing the cavity into sections, and means interconnecting opposing ones of the plurality of vanes for stabilizing the resonator.

Stabilized radio frequency quadrupole

DOEpatents

Lancaster, Henry D.; Fugitt, Jock A.; Howard, Donald R.

1984-01-01

A long-vane stabilized radio frequency resonator for accelerating charged particles and including means defining a radio frequency resonator cavity, a plurality of long vanes mounted in the defining means for dividing the cavity into sections, and means interconnecting opposing ones of the plurality of vanes for stabilizing the resonator.

Correlation of structural stability with functional remodeling of high-density lipoproteins: the importance of being disordered.

PubMed

Guha, Madhumita; Gao, Xuan; Jayaraman, Shobini; Gursky, Olga

2008-11-04

High-density lipoproteins (HDLs) are protein-lipid assemblies that remove excess cell cholesterol and prevent atherosclerosis. HDLs are stabilized by kinetic barriers that decelerate protein dissociation and lipoprotein fusion. We propose that similar barriers modulate metabolic remodeling of plasma HDLs; hence, changes in particle composition that destabilize HDLs and accelerate their denaturation may accelerate their metabolic remodeling. To test this notion, we correlate existing reports on HDL-mediated cell cholesterol efflux and esterification, which are obligatory early steps in cholesterol removal, with our kinetic studies of HDL stability. The results support our hypothesis and show that factors accelerating cholesterol efflux and esterification in model discoidal lipoproteins (including reduced protein size, reduced fatty acyl chain length, and/or increased level of cis unsaturation) destabilize lipoproteins and accelerate their fusion and apolipoprotein dissociation. Oxidation studies of plasma spherical HDLs show a similar trend: mild oxidation by Cu(2+) or OCl(-) accelerates cell cholesterol efflux, protein dissociation, and HDL fusion, while extensive oxidation inhibits these reactions. Consequently, moderate destabilization may be beneficial for HDL functions by facilitating insertion of cholesterol and lipophilic enzymes, promoting dissociation of lipid-poor apolipoproteins, which are primary acceptors of cell cholesterol, and thereby accelerating HDL metabolism. Therefore, HDL stability must be delicately balanced to maintain the structural integrity of the lipoprotein assembly and ensure structural specificity necessary for interactions of HDL with its metabolic partners, while facilitating rapid HDL remodeling and turnover at key junctures of cholesterol transport. The inverse correlation between HDL stability and remodeling illustrates the functional importance of structural disorder in macromolecular assemblies stabilized by kinetic barriers.

Thermochemical Stability Study of Alkyl-Tethered Quaternary Ammonium Cations for Anion Exchange Membrane Fuel Cells

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mohanty, Angela D.; Tignor, Steven E.; Sturgeon, Matthew R.

2017-01-01

The increased interest in the use of anion exchange membranes (AEMs) for applications in electrochemical devices has prompted significant efforts in designing materials with robust stability in alkaline media. Most reported AEMs suffer from polymer backbone degradation as well as cation functional group degradation. In this report, we provide comprehensive experimental investigations for the analysis of cation functional group stability under alkaline media. A silver oxide-mediated ion exchange method and an accelerated stability test in aqueous KOH solutions at elevated temperatures using a Parr reactor were used to evaluate a broad scope of quaternary ammonium (QA) cationic model compound structures,more » particularly focusing on alkyl-tethered cations. Additionally, byproduct analysis was employed to gain better understanding of degradation pathways and trends of alkaline stability. Experimental results under different conditions gave consistent trends in the order of cation stability of various QA small molecule model compounds. Overall, cations that are benzyl-substituted or that are near to electronegative atoms (such as oxygen) degrade faster in alkaline media in comparison to alkyl-tethered QAs. These comprehensive model compound stability studies provide valuable information regarding the relative stability of various cation structures and can help guide researchers towards designing new and promising candidates for AEM materials.« less

Tune-stabilized, non-scaling, fixed-field, alternating gradient accelerator

DOEpatents

Johnstone, Carol J [Warrenville, IL

2011-02-01

A FFAG is a particle accelerator having turning magnets with a linear field gradient for confinement and a large edge angle to compensate for acceleration. FODO cells contain focus magnets and defocus magnets that are specified by a number of parameters. A set of seven equations, called the FFAG equations relate the parameters to one another. A set of constraints, call the FFAG constraints, constrain the FFAG equations. Selecting a few parameters, such as injection momentum, extraction momentum, and drift distance reduces the number of unknown parameters to seven. Seven equations with seven unknowns can be solved to yield the values for all the parameters and to thereby fully specify a FFAG.

The effect of heat treatment on the stability of Nb 3Sn RRP-150/169 strands

DOE PAGES

Li, Pei; Turrioni, Daniele; Barzi, Emanuela; ...

2017-02-17

Here, the magnetic stability of superconductor strands and cables is a key issue in the successful building and operation of high-field accelerator magnets. In this paper, we report the study of a state-of-the-art 0.7 mm Nb 3Sn restacked-rod-process strand manufactured by Oxford Instrument Superconductor Technology. This conductor will be used in Rutherford cable for a 15-T Nb 3Sn dipole demonstrator being built at Fermi National Accelerator Laboratory. Particularly, this study focuses on the impact of varying heat treatment conditions on the stability of the strand. Both the stability against internal flux jumps and external thermal perturbations are studied.

The effect of heat treatment on the stability of Nb 3Sn RRP-150/169 strands

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li, Pei; Turrioni, Daniele; Barzi, Emanuela

Here, the magnetic stability of superconductor strands and cables is a key issue in the successful building and operation of high-field accelerator magnets. In this paper, we report the study of a state-of-the-art 0.7 mm Nb 3Sn restacked-rod-process strand manufactured by Oxford Instrument Superconductor Technology. This conductor will be used in Rutherford cable for a 15-T Nb 3Sn dipole demonstrator being built at Fermi National Accelerator Laboratory. Particularly, this study focuses on the impact of varying heat treatment conditions on the stability of the strand. Both the stability against internal flux jumps and external thermal perturbations are studied.

Stabilized radio frequency quadrupole

DOEpatents

Lancaster, H.D.; Fugitt, J.A.; Howard, D.R.

1984-12-25

Disclosed is a long-vane stabilized radio frequency resonator for accelerating charged particles and including means defining a radio frequency resonator cavity, a plurality of long vanes mounted in the defining means for dividing the cavity into sections, and means interconnecting opposing ones of the plurality of vanes for stabilizing the resonator. 5 figs.

Acceleration of polarized protons and deuterons in the ion collider ring of JLEIC

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kondratenko, A.; Kondratenko, M.; Filatov, Yu. N.

2017-07-01

The figure-8-shaped ion collider ring of Jefferson Lab Electron-Ion Collider (JLEIC) is transparent to the spin. It allows one to preserve proton and deuteron polarizations using weak stabilizing solenoids when accelerating the beam up to 100 GeV/c. When the stabilizing solenoids are introduced into the collider's lattice, the particle spins precess about a spin field, which consists of the field induced by the stabilizing solenoids and the zero-integer spin resonance strength. During acceleration of the beam, the induced spin field is maintained constant while the resonance strength experiences significant changes in the regions of "interference peaks". The beam polarization dependsmore » on the field ramp rate of the arc magnets. Its component along the spin field is preserved if acceleration is adiabatic. We present the results of our theoretical analysis and numerical modeling of the spin dynamics during acceleration of protons and deuterons in the JLEIC ion collider ring. We demonstrate high stability of the deuteron polarization in figure-8 accelerators. We analyze a change in the beam polarization when crossing the transition energy.« less

A reticle retrofit and dosimetric consideration for a linear accelerator.

PubMed

Krithivas, V

1996-01-01

An imperfect reticle system in an accelerator causes uncertainties in source-skin distance (SSD), off-axis distance (OAD), isocenter, and so forth. A reticle was designed and fabricated, and its implications on x-ray and electron beam dosimetry were investigated. A new reticle frame was dimensioned to fit snugly in the accelerator. The frame was fabricated to carry a pair of adjustable cross wires and to allow the machine operation in the photon and electron modes. The impact of the cross wires on 6 MV photon and 5-10 MeV electron beam parameters such as dose rate (Gy/monitor unit), beam uniformity, surface dose, and so forth, were studied using suitable ion chambers and phantoms. The retrofitted system offered long-term mechanical stability leading to precise SSD, OAD, and isocenter measurements. Changes introduced by the cross wires on the 6 MV photon and 5-10 MeV electron beams are presented. Long-term stability of a reticle in an accelerator is important for an accurate patient setup and for making reliable dosimetric measurements. Beam characteristrics have to be studied whenever modifications on a reticle system are made.

Acceleration of convergence of vector sequences

NASA Technical Reports Server (NTRS)

Sidi, A.; Ford, W. F.; Smith, D. A.

1983-01-01

A general approach to the construction of convergence acceleration methods for vector sequence is proposed. Using this approach, one can generate some known methods, such as the minimal polynomial extrapolation, the reduced rank extrapolation, and the topological epsilon algorithm, and also some new ones. Some of the new methods are easier to implement than the known methods and are observed to have similar numerical properties. The convergence analysis of these new methods is carried out, and it is shown that they are especially suitable for accelerating the convergence of vector sequences that are obtained when one solves linear systems of equations iteratively. A stability analysis is also given, and numerical examples are provided. The convergence and stability properties of the topological epsilon algorithm are likewise given.

Ram accelerator direct space launch system - New concepts

NASA Technical Reports Server (NTRS)

Bogdanoff, David W.

1992-01-01

The ram accelerator, a chemically driven ramjet-in-tube device is a new option for direct launch of acceleration-insensitive payloads into earth orbit. The projectile is the centerbody of a ramjet and travels through a tube filled with a premixed fuel-oxidizer mixture. The tube acts as the cowl of the ramjet. A number of new concepts for a ram accelerator space launch system are presented. The velocity and acceleration capabilities of a number of ram accelerator drive modes, including several new modes, are given. Passive (fin) stabilization during atmospheric transit is investigated and found to be promising. Gasdynamic heating in-tube and during atmospheric transit is studied; the former is found to be severe, but may be alleviated by the selection of the most suitable drive modes, transpiration cooling, or a hydrogen gas core in the launch tube. To place the payload in earth orbit, scenarios using one impulse and three impulses (with an aeropass) and a new scenario involving an auxiliary vehicle are studied. The auxiliary vehicle scenario is found to be competitive regarding payload, and requires a much simpler projectile, but has the disadvantage of requiring the auxiliary vehicle.

KLYNAC: Compact linear accelerator with integrated power supply

DOE Office of Scientific and Technical Information (OSTI.GOV)

Malyzhenkov, Alexander

Accelerators and accelerator-based light sources have a wide range of applications in science, engineering technology and medicine. Today the scienti c community is working towards improving the quality of the accelerated beam and its parameters while trying to develop technology for reducing accelerator size. This work describes a design of a compact linear accelerator (linac) prototype, resonant Klynac device, which is a combined linear accelerator and its power supply - klystron. The intended purpose of a Klynac device is to provide a compact and inexpensive alternative to a conventional 1 to 6 MeV accelerator, which typically requires a separate RFmore » source, an accelerator itself and all the associated hardware. Because the Klynac is a single structure, it has the potential to be much less sensitive to temperature variations than a system with separate klystron and linac. We start by introducing a simpli ed theoretical model for a Klynac device. We then demonstrate how a prototype is designed step-by-step using particle-in-cell simulation studies for mono- resonant and bi-resonant structures. Finally, we discuss design options from a stability point of view and required input power as well as behavior of competing modes for the actual built device.« less

Accelerated Aging of Lead-Free Propellant

NASA Technical Reports Server (NTRS)

Furrow, Keith W.; Jervey, David D.

2000-01-01

Following higher than expected 2-NDPA depletion rates in a lead-free doublebase formulation (RPD-422), an accelerated aging study was conducted to verify the depletion rates. A test plan was prepared to compare the aging characteristics of lead-free propellant and NOSIH-AA2. The study was also designed to determine which lead-free ballistic modifiers accelerated 2-NDPA depletion. The increased depletion rate occurred in propellants containing monobasic copper salicylate. Four lead-free propellants were then formulated to improved aging characteristics over previous lead-free propellant formulations. The new formulations reduced or replaced the monobasic copper salicylate. The new formulations had improved aging characteristics. Their burn rates, however, were unacceptable for use in a 2.75 inch rocket. To compare aging characteristics, stabilizer depletion rates of RPD-422, AA2, M28, and RLC 470/6A were measured or taken from the literature. The data were fit to a kinetic model. The model contained first and zero order terms which allowed the stabilizer concentration to go to zero. In the model, only the concentration of the primary stabilizer was considered. Derivatives beyond the first nitrated or nitroso derivative of 2-NPDA were not considered. The rate constants were fit to the Arrhenius equation and extrapolated to lower temperatures. The time to complete stabilizer depletion was estimated using the kinetic model. The four propellants were compared and the RPD-422 depleted faster at 45 C than both A22 and M28. These types of predictions depend on the validity of the model and on confidence in the Arrhenius relationship holding at lower temperatures. At 45 C, the zero order portion of the model dominates the depletion rate.

Study of Running Stability in Side-Suspended HTS-PMG Maglev Circular Line System

NASA Astrophysics Data System (ADS)

Zhou, Dajin; Zhao, Lifeng; Li, Linbo; Cui, Chenyu; Hsieh, Chang-Chun; Zhang, Yong; Guo, Jianqiang; Zhao, Yong

2017-07-01

A research on stability of the side-suspended HTS-PMG maglev circular line system is carried out through simulation experiment. The results show that the maglev vehicle will gradually get close to the track surface during acceleration under the action of centrifugal force, leading to decay of guidance force and occurrence of vertical eccentric motion. In case of linear array of YBa2Cu3O7-x (YBCO) bulks, the guidance force will be changed with the decreasing of the levitation gap. It can be suppressed through the complex arrangement of YBCO bulks. Fortunately, triangle array of YBCO bulks can effectively keep the guidance force constant and realize stable running during accelerating process of the prototype vehicle. Based on the research on stability of side-suspended maglev vehicle, a side-suspended PMG circular test track with diameter of 6.5 m and circumference of 20.4 m is successfully designed and established, enabling the prototype vehicle to run stably at up to 82.5 km/h under open atmosphere (9.6 × 104 Pa).

Enhanced stability and chemical resistance of a new nanoscale biocatalyst for accelerating CO2 absorption into a carbonate solution.

PubMed

Zhang, Shihan; Lu, Hong; Lu, Yongqi

2013-12-03

A novel potassium-carbonate-based absorption process is currently being developed to reduce the energy consumption when capturing CO2 from coal combustion flue gas. The process employs the enzyme carbonic anhydrase (CA) as a catalyst to accelerate the rate of CO2 absorption. This study focused on the immobilization of a new variant of the CA enzyme onto a new group of nonporous nanoparticles to improve the enzyme's thermal stability and its chemical resistance to major impurities from the flue gas. The CA enzyme was manufactured at the pilot scale by a leading enzyme company. As carrier materials, two different batches of SiO2-ZrO2 composite nanoparticles and one batch of silica nanoparticle were synthesized using a flame spray pyrolysis method. Classic Danckwerts absorption theory with reaction was applied to determine the kinetics of the immobilized enzymes for CO2 absorption. The immobilized enzymes retained 56-88% of their original activity in a K2CO3/KHCO3 solution over a 60-day test period at 50 °C, compared with a 30% activity retention for their free CA enzyme counterpart. The immobilized CA enzymes also revealed improved chemical stability. The inactivation kinetics of the free and immobilized CA enzymes in the K2CO3/KHCO3 solution were experimentally quantified.

Evaluation of asymmetric quadrupoles for a non-scaling fixed field alternating gradient accelerator

NASA Astrophysics Data System (ADS)

Lee, Sang-Hun; Park, Sae-Hoon; Kim, Yu-Seok

2017-12-01

A non-scaling fixed field alternating gradient (NS-FFAG) accelerator was constructed, which employs conventional quadrupoles. The possible demerit is the beam instability caused by the variable focusing strength when the orbit radius of the beam changes. To overcome this instability, it was suggested that the asymmetric quadrupole has different current flows in each coil. The magnetic field of the asymmetric quadrupole was found to be more similar to the magnetic field required for the FFAG accelerator than the constructed NS-FFAG accelerator. In this study, a simulation of the beam dynamics was carried out to evaluate the improvement to the beam stability for the NS-FFAG accelerator using the SIMION program. The beam dynamics simulation was conducted with the `hard edge' model; it ignored the fringe field at the end of the magnet. The magnetic field map of the suggested magnet was created using the SIMION program. The lattices for the simulation combined the suggested magnets. The magnets were evaluated for beam stability in the lattices through the SIMION program.

Fluid Physics Under a Stochastic Acceleration Field

NASA Technical Reports Server (NTRS)

Vinals, Jorge

2001-01-01

The research summarized in this report has involved a combined theoretical and computational study of fluid flow that results from the random acceleration environment present onboard space orbiters, also known as g-jitter. We have focused on a statistical description of the observed g-jitter, on the flows that such an acceleration field can induce in a number of experimental configurations of interest, and on extending previously developed methodology to boundary layer flows. Narrow band noise has been shown to describe many of the features of acceleration data collected during space missions. The scale of baroclinically induced flows when the driving acceleration is random is not given by the Rayleigh number. Spatially uniform g-jitter induces additional hydrodynamic forces among suspended particles in incompressible fluids. Stochastic modulation of the control parameter shifts the location of the onset of an oscillatory instability. Random vibration of solid boundaries leads to separation of boundary layers. Steady streaming ahead of a modulated solid-melt interface enhances solute transport, and modifies the stability boundaries of a planar front.

Racetrack-shape fixed field induction accelerator for giant cluster ions

NASA Astrophysics Data System (ADS)

Takayama, Ken; Adachi, Toshikazu; Wake, Masayoshi; Okamura, Katsuya

2015-05-01

A novel scheme for a racetrack-shape fixed field induction accelerator (RAFFIA) capable of accelerating extremely heavy cluster ions (giant cluster ions) is described. The key feature of this scheme is rapid induction acceleration by localized induction cells. Triggering the induction voltages provided by the signals from the circulating bunch allows repeated acceleration of extremely heavy cluster ions. The given RAFFIA example is capable of realizing the integrated acceleration voltage of 50 MV per acceleration cycle. Using 90° bending magnets with a reversed field strip and field gradient is crucial for assuring orbit stability in the RAFFIA.

Effect of mouthwash and accelerated aging on the color stability of esthetic restorative materials.

PubMed

Lee, Y K; El Zawahry, M; Noaman, K M; Powers, J M

2000-06-01

To evaluate the color stability of esthetic restorative materials after immersion in mouthwashes and accelerated aging. Compomers and resin-based composites (RBC) were measured at baseline and repeatedly after immersion in three kinds of mouthwash (Listerine, Peridex, Rembrandt Age Defying) for 24 hrs and 7 days, and after aging for 150 kJ/m2. Color was measured according to CIE L*a*b* color scale on a reflection spectrophotometer. After immersion for 7 days, the mouthwash groups did not produce significantly higher color changes than the distilled water group, except with some mouthwashes used with Tetric-Ceram. After immersion for 7 days and aging for 150 kJ/m2, the mouthwash groups did not produce significantly higher color changes than the distilled water group. Aging in weathering chamber produced color change (deltaE*) of 1.1-3.9, which was mainly influenced by the material. With some exceptions, the color changes from immersion of the RBCs and compomers in mouthwashes were not perceptible (deltaE*<3.3).

Local Dynamic Stability Associated with Load Carrying

PubMed Central

Lockhart, Thurmon E

2013-01-01

Objectives Load carrying tasks are recognized as one of the primary occupational factors leading to slip and fall injuries. Nevertheless, the mechanisms associated with load carrying and walking stability remain illusive. The objective of the current study was to apply local dynamic stability measure in walking while carrying a load, and to investigate the possible adaptive gait stability changes. Methods Current study involved 25 young adults in a biomechanics research laboratory. One tri-axial accelerometer was used to measure three-dimensional low back acceleration during continuous treadmill walking. Local dynamic stability was quantified by the maximum Lyapunov exponent (maxLE) from a nonlinear dynamics approach. Results Long term maxLE was found to be significant higher under load condition than no-load condition in all three reference axes, indicating the declined local dynamic stability associated with load carrying. Conclusion Current study confirmed the sensitivity of local dynamic stability measure in load carrying situation. It was concluded that load carrying tasks were associated with declined local dynamic stability, which may result in increased risk of fall accident. This finding has implications in preventing fall accidents associated with occupational load carrying. PMID:23515183

Comparison of solidification/stabilization effects of calcite between Australian and South Korean cements

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lee, Dongjin; Waite, T. David; Swarbrick, Gareth

2005-11-15

The differences in the effect of calcite on the strength and stability of Pb-rich wastes solidified and stabilized using Australian and South Korean ordinary Portland cements are examined in this study. Pb-rich waste stabilized using Australian OPC has been shown to possess both substantially higher unconfined compressive strength and lead immobilization ability than South Korean OPC as a result of its higher C{sub 3}S content and the associated enhanced degree of precipitation of lead on the surfaces of silicate phases present. Calcite addition is observed to have an accelerating effect on the OPC-induced solidification/stabilization of Pb-rich wastes as gauged bymore » the unconfined compressive strength and leachability of the solids formed. This effect is observed to be far more dramatic for South Korean OPC than for Australian OPC. Using scanning electron microscopy, waste stabilized with cement and calcite was observed to develop significantly greater proportions of hydrated crystals than wastes stabilized with cement alone. The results of X-ray diffraction studies have shown that the presence of calcite in South Korean OPC results in greater acceleration in the formation of portlandite than is the case for Australian OPC.« less

Evaluation of accelerated UV and thermal testing for benzene formation in beverages containing benzoate and ascorbic acid.

PubMed

Nyman, Patricia J; Wamer, Wayne G; Begley, Timothy H; Diachenko, Gregory W; Perfetti, Gracia A

2010-04-01

Under certain conditions, benzene can form in beverages containing benzoic and ascorbic acids. The American Beverage Assn. (ABA) has published guidelines to help manufacturers mitigate benzene formation in beverages. These guidelines recommend accelerated testing conditions to test product formulations, because exposure to ultraviolet (UV) light and elevated temperature over the shelf life of the beverage may result in benzene formation in products containing benzoic and ascorbic acids. In this study, the effects of UVA exposure on benzene formation were determined. Benzene formation was examined for samples contained in UV stabilized and non-UV stabilized packaging. Additionally, the usefulness of accelerated thermal testing to simulate end of shelf-life benzene formation was evaluated for samples containing either benzoic or ascorbic acid, or both. The 24 h studies showed that under intense UVA light benzene levels increased by as much as 53% in model solutions stored in non-UV stabilized bottles, whereas the use of UV stabilized polyethylene terephthalate bottles reduced benzene formation by about 13% relative to the non-UV stabilized bottles. Similar trends were observed for the 7 d study. Retail beverages and positive and negative controls were used to study the accelerated thermal testing conditions. The amount of benzene found in the positive controls and cranberry juice suggests that testing at 40 degrees C for 14 d may more reliably simulate end of shelf-life benzene formation in beverages. Except for cranberry juice, retail beverages were not found to contain detectable amounts of benzene (<0.05 ng/g) at the end of their shelf lives.

[Stability of disintegration in health food].

PubMed

Ma, Lan; Zhao, Xin; Zhou, Shuang; Yang, Dajin

2012-11-01

To study the change of disintegration of different formulation samples which stored in the artificial climate box or room temperature and provide the technical support for health food monitoring. According to the method of Chinese Pharmacopoeia and British Pharmacopoeia. Appendix XII A. Disintegration 2010. Disintegration of the non-accelerate, accelerated after 1, 2 and 3 months samples were determined by the disintegrator, respectively. Sample properties, the ingredients of the samples, the proportions of the capsule and treatment methods have some effect on the stability of the disintegration. The disintegration time of health food will be changed particularly after they were accelerated under the condition of (38 +/- 1) degrees C/75% RH. Especially the disintegration time of soft capsules were significantly prolonged. The composition and properties of samples were the main factors that affected the disintegration.

Influence of artificial accelerated ageing on the colour stability of paints used for ocular prosthesis iris painting.

PubMed

Mundim, Fabrício M; Antunes, Pedro L; Sousa, Ana Beatriz S; Garcia, Lucas F R; Pires-de-Souza, Fernanda C P

2012-06-01

To evaluate the colour stability of paints used for ocular prosthesis iris painting submitted for accelerated artificial ageing (AAA). Forty specimens of acrylic resin for sclera (16 × 2 mm) were made and separated into eight groups (n = 10) according to the type of paint (gouache, GP; oil, OP; acrylic AP; and composite resin for characterisation, CR) and the colours used (blue/brown). After drying (72 h), a new layer of colourless acrylic resin was applied and the initial colour readout was performed (Spectrophotometer PCB 6807). New colour readouts were performed after AAA, and ΔE was calculated. Statistical analysis (two-way anova-Bonferroni, p < 0.05) demonstrated that the brown colour showed lower ΔE means in comparison with the blue colour, with statistically significant difference for AP only. Blue colour showed no statistically significant difference with regard to the type of paint used. Brown AP showed lower ΔE than the other groups, with significant difference for OP and GP. GP showed greater alteration in ΔE for the brown colour, being statistically similar only to OP. Only the AP group for brown pigment shows clinically acceptable values for colour stability after AAA. © 2011 The Gerodontology Society and John Wiley & Sons A/S.

Transient aerodynamic characteristics of vans during the accelerated overtaking process

NASA Astrophysics Data System (ADS)

Liu, Li-ning; Wang, Xing-shen; Du, Guang-sheng; Liu, Zheng-gang; Lei, Li

2018-04-01

This paper studies the influence of the accelerated overtaking process on the vehicles' transient aerodynamic characteristics, through 3-D numerical simulations with dynamic meshes and sliding interface technique. Numerical accuracy is verified by experimental results. The aerodynamic characteristics of vehicles in the uniform overtaking process and the accelerated overtaking process are compared. It is shown that the speed variation of the overtaking van would influence the aerodynamic characteristics of the two vans, with greater influence on the overtaken van than on the overtaking van. The simulations of three different accelerated overtaking processes show that the greater the acceleration of the overtaking van, the larger the aerodynamic coefficients of the overtaken van. When the acceleration of the overtaking van increases by 1 m/s2, the maximum drag force, side force and yawing moment coefficients of the overtaken van all increase by more than 6%, to seriously affect the power performance and the stability of the vehicles. The analysis of the pressure fields under different accelerated conditions reveals the cause of variations of the aerodynamic characteristics of vehicles.

Current-driven plasma acceleration versus current-driven energy dissipation. I - Wave stability theory

NASA Technical Reports Server (NTRS)

Kelly, A. J.; Jahn, R. G.; Choueiri, E. Y.

1990-01-01

The dominant unstable electrostatic wave modes of an electromagnetically accelerated plasma are investigated. The study is the first part of a three-phase program aimed at characterizing the current-driven turbulent dissipation degrading the efficiency of Lorentz force plasma accelerators such as the MPD thruster. The analysis uses a kinetic theory that includes magnetic and thermal effects as well as those of an electron current transverse to the magnetic field and collisions, thus combining all the features of previous models. Analytical and numerical solutions allow a detailed description of threshold criteria, finite growth behavior, destabilization mechanisms and maximized-growth characteristics of the dominant unstable modes. The lower hybrid current-driven instability is implicated as dominant and was found to preserve its character in the collisional plasma regime.

Thermal-stability studies of electrode materials for lithium-ion batteries

NASA Astrophysics Data System (ADS)

Jiang, Junwei

2005-07-01

The thermal stability of lithium-ion batteries has recently attracted attention for two major reasons. (1) Attempts to make large-size cells used in power tools, E-bikes and EVs. Large cells have lower surface area to volume ratios and hence heat dissipation is more problematic than 18650-size cells. Safety problems, therefore, for large cells are more serious. (2) Next generation high-capacity electrodes will increase the energy density of lithium-ion cells meaning even an 18650-size cell may face safety concerns. This thesis presents studies of the thermal stability of electrode materials in electrolytes to understand their reactivity. A search for new positive electrode materials with high thermal stability was made. The thermal stability of two common electrode materials (Li0.81 C6 and Li0.5CoO2) in lithium-ion cells was studied by Accelerating Rate Calorimeter (ARC). Li0.81C 6 has much lower reactivity with lithium bis(oxalato)borate (LiBOB) electrolyte compared to LiPF6 electrolyte. It is not the case, however, for Li0.5CoO2. Oven tests of full LiCoO 2/C 18650-size cells with LiBOB or LiPF6 electrolytes, confirmed the ARC results. ARC was then used to study the reactivity of existing electrode materials. The thermal stability of a negative electrode material was found to increase with the binding energy of Li atoms hosted in the material. Li0.5VO 2 (B) has a higher lithium binding energy (2.45 eV vs. Li) than Li 0.81C6 (0.1 eV vs. Li) and Li7Ti5O 12 (1.55 eV) and it shows the highest thermal stability in EC/DEC among the three materials. The reactivity of two existing positive electrode materials, LiMn2O4 and LiFePO4, was studied. Cell systems expected to be highly tolerant to thermal abuse were suggested: LiFePO 4/C or Li4Ti5O12 in LiBOB electrolytes. The system, x Li[Ni1/2Mn1/2]O2 • y LiCoO2 • z Li[Li1/3Mn2/3]O2 (x + y + z = 1), was explored for new positive electrode materials with large capacity and high thermal stability. Li[(Ni0.5Mn0.5) xCo1-x]O2 (0

Artifactual degradation of secondary amine-containing drugs during accelerated stability testing when saturated sodium nitrite solutions are used for humidity control.

PubMed

Sluggett, Gregory W; Zelesky, Todd; Hetrick, Evan M; Babayan, Yelizaveta; Baertschi, Steven W

2018-02-05

Accelerated stability studies of pharmaceutical products are commonly conducted at various combinations of temperature and relative humidity (RH). The RH of the sample environment can be controlled to set points using humidity-controlled stability chambers or via storage of the sample in a closed container in the presence of a saturated aqueous salt solution. Herein we report an unexpected N-nitrosation reaction that occurs upon storage of carvedilol- or propranolol-excipient blends in a stability chamber in the presence of saturated sodium nitrite (NaNO 2 ) solution to control relative humidity (∼60% RH). In both cases, the major products were identified as the corresponding N-nitroso derivatives of the secondary amine drugs based on mass spectrometry, UV-vis and retention time. These degradation products were not observed upon storage of the samples at the same temperature and humidity but in the presence of saturated potassium iodide (KI) solution (∼60% RH) for humidity control. The levels of the N-nitrosamine derivatives varied with the pH of various NaNO 2 batches. The presence of volatile NOx species in the headspace of a container containing saturated NaNO 2 solution was confirmed via the Griess assay. The process for formation of the N-nitrosamine derivatives is proposed to involve volatilization of nitric oxide (NO) from aqueous nitrite solution into the headspace of the container followed by diffusion into the solid drug-excipient blend and subsequent reaction of NOx with the secondary amine. Copyright © 2017 Elsevier B.V. All rights reserved.

Walking stability and sensorimotor function in older people with diabetic peripheral neuropathy.

PubMed

Menz, Hylton B; Lord, Stephen R; St George, Rebecca; Fitzpatrick, Richard C

2004-02-01

To evaluate, in older people with diabetic peripheral neuropathy (DPN) and in age-matched controls, acceleration patterns of the head and pelvis when walking to determine the effect of lower-limb sensory loss on walking stability. Case-control study. Falls and balance laboratory in Australia. Thirty persons with diabetes mellitus (age range, 55-91 y) and 30 age-matched controls. Acceleration patterns of the head and pelvis were measured while participants walked on a level surface and an irregular walkway. Participants also underwent tests of vision, sensation, strength, reaction time, and balance. Temporospatial gait parameters and variables derived from acceleration signals. Participants with DPN had reduced walking speed, cadence, and step length, and less rhythmic acceleration patterns at the head and pelvis compared with controls. These differences were particularly evident when participants walked on the irregular surface. Participants with DPN also had impaired peripheral sensation, reaction time, and balance. Older people with DPN have an impaired ability to stabilize their body when walking on irregular surfaces, even if they adopt a more conservative gait pattern. These results provide further insights into the role of peripheral sensory input in the control of gait stability, and suggest possible mechanisms underlying the increased risk of falling in older people with diabetic neuropathy.

Influence of Different Types of Resin Luting Agents on Color Stability of Ceramic Laminate Veneers Subjected to Accelerated Artificial Aging.

PubMed

Silami, Francisca Daniele Jardilino; Tonani, Rafaella; Alandia-Román, Carla Cecilia; Pires-de-Souza, Fernanda de Carvalho Panzeri

2016-01-01

The aim of this study was to evaluate the influence of accelerated aging (AAA) on the color stability of resin cements for bonding ceramic laminate veneers of different thicknesses. The occlusal surfaces of 80 healthy human molars were flattened. Ceramic laminate veneers (IPS e-max Ceram) of two thicknesses (0.5 and 1.0 mm) were bonded with three types of luting agents: light-cured, conventional dual and self-adhesive dual cement. Teeth without restorations and cement samples (0.5 mm) were used as control. After initial color evaluations, the samples were subjected to AAA for 580 h. After this, new color readouts were made, and the color stability (ΔE) and luminosity (ΔL) data were analyzed. The greatest color changes (p<0.05) occurred when 0.5 mm veneers were fixed with light-cured cement and the lowest when 1.0 mm veneers were fixed with conventional dual cement. There was no influence of the restoration thickness when the self-adhesive dual cement was used. When veneers were compared with the control groups, it was verified that the cement samples presented the greatest alterations (p<0.05) in comparison with both substrates and restored teeth. Therefore, it was concluded that the thickness of the restoration influences color and luminosity changes for conventional dual and light-cured cements. The changes in self-adhesive cement do not depend on restoration thickness.

Methods of Phase and Power Control in Magnetron Transmitters for Superconducting Accelerators

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kazadevich, G.; Johnson, R.; Neubauer, M.

Various methods of phase and power control in magnetron RF sources of superconducting accelerators intended for ADS-class projects were recently developed and studied with conventional 2.45 GHz, 1 kW, CW magnetrons operating in pulsed and CW regimes. Magnetron transmitters excited by a resonant (injection-locking) phasemodulated signal can provide phase and power control with the rates required for precise stabilization of phase and amplitude of the accelerating field in Superconducting RF (SRF) cavities of the intensity-frontier accelerators. An innovative technique that can significantly increase the magnetron transmitter efficiency at the widerange power control required for superconducting accelerators was developed and verifiedmore » with the 2.45 GHz magnetrons operating in CW and pulsed regimes. High efficiency magnetron transmitters of this type can significantly reduce the capital and operation costs of the ADSclass accelerator projects.« less

Terahertz Pulsed Imaging and Magnetic Resonance Imaging as Tools to Probe Formulation Stability

PubMed Central

Zhang, Qilei; Gladden, Lynn F.; Avalle, Paolo; Zeitler, J. Axel; Mantle, Michael D.

2013-01-01

Dissolution stability over the entire shelf life duration is of critical importance to ensure the quality of solid dosage forms. Changes in the drug release profile during storage may affect the bioavailability of drug products. This study investigated the stability of a commercial tablet (Lescol® XL) when stored under accelerated conditions (40 °C/75% r.h.). Terahertz pulsed imaging (TPI) was used to investigate the structure of the tablet coating before and after the accelerated aging process. The results indicate that the coating was reduced in thickness and exhibited a higher density after being stored under accelerated conditions for four weeks. In situ magnetic resonance imaging (MRI) of the water penetration processes during tablet dissolution in a USP-IV dissolution cell equipped with an in-line UV-vis analyzer was carried out to study local differences in water uptake into the tablet matrix between the stressed and unstressed state. The drug release profiles of the Lescol® XL tablet before and after the accelerated storage stability testing were compared using a “difference” factor f1 and a “similarity” factor f2. The results reveal that even though the physical properties of the coating layers changed significantly during the stress testing, the coating protected the tablet matrix and the densification of the coating polymer had no adverse effect on the drug release performance. PMID:24300564

Stability of simulated flight path control at +3 Gz in a human centrifuge.

PubMed

Guardiera, Simon; Dalecki, Marc; Bock, Otmar

2010-04-01

Earlier studies have shown that naïve subjects and experienced jet pilots produce exaggerated manual forces when exposed to increased acceleration (+Gz). This study was designed to evaluate whether this exaggeration affects the stability of simulated flight path control. We evaluated naïve subjects' performance in a flight simulator which either remained stationary (+1 Gz), or rotated to induce an acceleration in accordance to the simulated flight path with a mean acceleration of about +3 Gz. In either case, subjects were requested to produce a series of altitude changes in pursuit of a visual target airplane. Resulting flight paths were analyzed to determine the largest oscillation after an altitude change (Oscillation) and the mean deviation between subject and target flight path (Tracking Error). Flight stability after an altitude change was degraded in +3 Gz compared to +1 Gz, as evidenced by larger Oscillations (+11%) and increased Tracking Errors (+80%). These deficits correlated significantly with subjects' +3 Gz deficits in a manual-force production task. We conclude that force exaggeration in +3 Gz may impair flight stability during simulated jet maneuvers in naïve subjects, most likely as a consequence of vestibular stimulation.

Design of an electromagnetic accelerator for turbulent hydrodynamic mix studies

NASA Astrophysics Data System (ADS)

Susoeff, A. R.; Hawke, R. S.; Morrison, J. J.; Dimonte, G.; Remington, B. A.

1993-12-01

An electromagnetic accelerator in the form of a linear electric motor (LEM) has been designed to achieve controlled acceleration profiles of a carriage containing hydrodynamically unstable fluids for the investigation of the development of turbulent mix. The Rayleigh-Taylor instability is investigated by accelerating two dissimilar density fluids using the LEM to achieve a wide variety of acceleration and deceleration profiles. The acceleration profiles are achieved by independent control of rail and augmentation currents. A variety of acceleration-time profiles are possible including: (1) constant, (2) impulsive and (3) shaped. The LEM and support structure are a robust design in order to withstand high loads with deflections and to mitigate operational vibration. Vibration of the carriage during acceleration could create artifacts in the data which would interfere with the intended study of the Rayleigh-Taylor instability. The design allows clear access for diagnostic techniques such as laser induced fluorescence radiography, shadowgraphs and particle imaging velocimetry. Electromagnetic modeling codes were used to optimize the rail and augmentation coil positions within the support structure framework. Results of contemporary studies for non-arcing sliding contact of solid armatures are used for the design of the driving armature and the dynamic electromagnetic braking system. A 0.6MJ electrolytic capacitor bank is used for energy storage to drive the LEM. This report will discuss a LEM design which will accelerate masses of up to 3kg to a maximum of about 3000g(sub o), where g(sub o) is accelerated due to gravity.

Comparison of clinical explants and accelerated hydrolytic aging to improve biostability assessment of silicone-based polyurethanes.

PubMed

Cosgriff-Hernandez, Elizabeth; Tkatchouk, Ekaterina; Touchet, Tyler; Sears, Nick; Kishan, Alysha; Jenney, Christopher; Padsalgikar, Ajay D; Chen, Emily

2016-07-01

Although silicone-based polyurethanes have demonstrated increased oxidative stability, there have been conflicting reports of the long-term hydrolytic stability of Optim™ and PurSil(®) 35 based on recent temperature-accelerated hydrolysis studies. The goal of the current study was to identify in vitro-in vivo correlations to determine the relevance of this accelerated in vitro model for predicting clinical outcomes. Temperature-accelerated hydrolytic aging of three commonly used cardiac lead insulation materials, Optim™, Elasthane™ 55D, Elasthane™ 80A, and a related silicone-polyurethane, PurSil(®) 35, was performed. After 1 year at 85°C, similar losses in Mn and Mz were observed for the poly(ether urethanes), but an increase in Mz loss as compared to Mn loss was observed for the silicone-based polyurethanes. A similar trend of increased Mz loss as compared to Mn loss was observed in explanted Optim™ leads after 2-3 years; however, no statistically significant Mn loss was detected between 2-3 and 7-8 years of implantation. Given this preferential loss of high molecular weight chains, it was hypothesized that the observed differences between the polyurethanes were due to allophanate dissociation rather than backbone chain scission. Following full dissociation of the small percentage of allophanates in vivo, the observed molecular weight stability and proven clinical performance of Optim™ was attributed to the well-documented stability of the urethane bond under physiological conditions. This allophanate dissociation reaction is incompatible with the first order mechanism proposed in previous temperature-accelerated hydrolysis studies and may be the reason for the model's inaccurate prediction of significant and progressive molecular weight loss in vivo. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 1805-1816, 2016. © 2016 Wiley Periodicals, Inc.

Vibration waveform effects on dynamic stabilization of ablative Rayleigh-Taylor instability

DOE Office of Scientific and Technical Information (OSTI.GOV)

Piriz, A. R.; Lucchio, L. Di; Rodriguez Prieto, G.

2011-08-15

An analysis of dynamic stabilization of Rayleigh-Taylor instability in an ablation front is performed by considering a general square wave for modulating the vertical acceleration of the front. Such a kind of modulation allows for clarifying the role of thermal conduction in the mechanism of dynamic stabilization. In addition, the study of the effect of different modulations by varying the duration and amplitude of the square wave in each half-period provides insight on the optimum performance of dynamic stabilization.

Studying astrophysical particle acceleration with laser-driven plasmas

NASA Astrophysics Data System (ADS)

Fiuza, Frederico

2016-10-01

The acceleration of non-thermal particles in plasmas is critical for our understanding of explosive astrophysical phenomena, from solar flares to gamma ray bursts. Particle acceleration is thought to be mediated by collisionless shocks and magnetic reconnection. The microphysics underlying these processes and their ability to efficiently convert flow and magnetic energy into non-thermal particles, however, is not yet fully understood. By performing for the first time ab initio 3D particle-in-cell simulations of the interaction of both magnetized and unmagnetized laser-driven plasmas, it is now possible to identify the optimal parameters for the study of particle acceleration in the laboratory relevant to astrophysical scenarios. It is predicted for the Omega and NIF laser conditions that significant non-thermal acceleration can occur during magnetic reconnection of laser-driven magnetized plasmas. Electrons are accelerated by the electric field near the X-points and trapped in contracting magnetic islands. This leads to a power-law tail extending to nearly a hundred times the thermal energy of the plasma and that contains a large fraction of the magnetic energy. The study of unmagnetized interpenetrating plasmas also reveals the possibility of forming collisionless shocks mediated by the Weibel instability on NIF. Under such conditions, both electrons and ions can be energized by scattering out of the Weibel-mediated turbulence. This also leads to power-law spectra that can be detected experimentally. The resulting experimental requirements to probe the microphysics of plasma particle acceleration will be discussed, paving the way for the first experiments of these important processes in the laboratory. As a result of these simulations and theoretical analysis, there are new experiments being planned on the Omega, NIF, and LCLS laser facilities to test these theoretical predictions. This work was supported by the SLAC LDRD program and DOE Office of Science, Fusion

Stability of buffer-free freeze-dried formulations: A feasibility study of a monoclonal antibody at high protein concentrations.

PubMed

Garidel, Patrick; Pevestorf, Benjamin; Bahrenburg, Sven

2015-11-01

We studied the stability of freeze-dried therapeutic protein formulations over a range of initial concentrations (from 40 to 160 mg/mL) and employed a variety of formulation strategies (including buffer-free freeze dried formulations, or BF-FDF). Highly concentrated, buffer-free liquid formulations of therapeutic monoclonal antibodies (mAbs) have been shown to be a viable alternative to conventionally buffered preparations. We considered whether it is feasible to use the buffer-free strategy in freeze-dried formulations, as an answer to some of the known drawbacks of conventional buffers. We therefore conducted an accelerated stability study (24 weeks at 40 °C) to assess the feasibility of stabilizing freeze-dried formulations without "classical" buffer components. Factors monitored included pH stability, protein integrity, and protein aggregation. Because the protein solutions are inherently self-buffering, and the system's buffer capacity scales with protein concentration, we included highly concentrated buffer-free freeze-dried formulations in the study. The tested formulations ranged from "fully formulated" (containing both conventional buffer and disaccharide stabilizers) to "buffer-free" (including formulations with only disaccharide lyoprotectant stabilizers) to "excipient-free" (with neither added buffers nor stabilizers). We evaluated the impacts of varying concentrations, buffering schemes, pHs, and lyoprotectant additives. At the end of 24 weeks, no change in pH was observed in any of the buffer-free formulations. Unbuffered formulations were found to have shorter reconstitution times and lower opalescence than buffered formulations. Protein stability was assessed by visual inspection, sub-visible particle analysis, protein monomer content, charge variants analysis, and hydrophobic interaction chromatography. All of these measures found the stability of buffer-free formulations that included a disaccharide stabilizer comparable to buffer

The spinning disc: studying radial acceleration and its damping process with smartphone acceleration sensors

NASA Astrophysics Data System (ADS)

Hochberg, K.; Gröber, S.; Kuhn, J.; Müller, A.

2014-03-01

Here, we show the possibility of analysing circular motion and acceleration using the acceleration sensors of smartphones. For instance, the known linear dependence of the radial acceleration on the distance to the centre (a constant angular frequency) can be shown using multiple smartphones attached to a revolving disc. As a second example, the decrease of the radial acceleration and the rotation frequency due to friction can be measured and fitted with a quadratic function, in accordance with theory. Finally, because the disc is not set up exactly horizontal, each smartphone measures a component of the gravitational acceleration that adds to the radial acceleration during one half of the period and subtracts from the radial acceleration during the other half. Hence, every graph shows a small modulation, which can be used to determine the rotation frequency, thus converting a ‘nuisance effect’ into a source of useful information, making additional measurements with stopwatches or the like unnecessary.

Utility of High Throughput Screening Techniques to Predict Stability of Monoclonal Antibody Formulations During Early Stage Development.

PubMed

Goldberg, Deborah S; Lewus, Rachael A; Esfandiary, Reza; Farkas, David C; Mody, Neil; Day, Katrina J; Mallik, Priyanka; Tracka, Malgorzata B; Sealey, Smita K; Samra, Hardeep S

2017-08-01

Selecting optimal formulation conditions for monoclonal antibodies for first time in human clinical trials is challenging due to short timelines and reliance on predictive assays to ensure product quality and adequate long-term stability. Accelerated stability studies are considered to be the gold standard for excipient screening, but they are relatively low throughput and time consuming. High throughput screening (HTS) techniques allow for large amounts of data to be collected quickly and easily, and can be used to screen solution conditions for early formulation development. The utility of using accelerated stability compared to HTS techniques (differential scanning light scattering and differential scanning fluorescence) for early formulation screening was evaluated along with the impact of excipients of various types on aggregation of monoclonal antibodies from multiple IgG subtypes. The excipient rank order using quantitative HTS measures was found to correlate with accelerated stability aggregation rate ranking for only 33% (by differential scanning fluorescence) to 42% (by differential scanning light scattering) of the antibodies tested, due to the high intrinsic stability and minimal impact of excipients on aggregation rates and HTS data. Also explored was a case study of employing a platform formulation instead of broader formulation screening for early formulation development. Copyright © 2017 American Pharmacists Association®. Published by Elsevier Inc. All rights reserved.

Berkeley Proton Linear Accelerator

DOE R&D Accomplishments Database

Alvarez, L. W.; Bradner, H.; Franck, J.; Gordon, H.; Gow, J. D.; Marshall, L. C.; Oppenheimer, F. F.; Panofsky, W. K. H.; Richman, C.; Woodyard, J. R.

1953-10-13

A linear accelerator, which increases the energy of protons from a 4 Mev Van de Graaff injector, to a final energy of 31.5 Mev, has been constructed. The accelerator consists of a cavity 40 feet long and 39 inches in diameter, excited at resonance in a longitudinal electric mode with a radio-frequency power of about 2.2 x 10{sup 6} watts peak at 202.5 mc. Acceleration is made possible by the introduction of 46 axial "drift tubes" into the cavity, which is designed such that the particles traverse the distance between the centers of successive tubes in one cycle of the r.f. power. The protons are longitudinally stable as in the synchrotron, and are stabilized transversely by the action of converging fields produced by focusing grids. The electrical cavity is constructed like an inverted airplane fuselage and is supported in a vacuum tank. Power is supplied by 9 high powered oscillators fed from a pulse generator of the artificial transmission line type.

Food Fortification Stability Study

NASA Technical Reports Server (NTRS)

Sirmons, T. A.; Cooper, M. R.; Douglas, G. L.

2016-01-01

This study aims to assess the stability of vitamin content, sensory acceptability and color variation in fortified spaceflight foods over a period of 2 years. Findings will identify optimal formulation, processing, and storage conditions to maintain stability and acceptability of commercially available fortification nutrients. Changes in food quality are being monitored to indicate whether fortification affects quality over time (compared to the unfortified control), thus indicating their potential for use on long-duration missions.

Food Fortification Stability Study

NASA Technical Reports Server (NTRS)

Sirmons, T. A.; Cooper, M. R.; Douglas, G. L.

2017-01-01

This study aimed to assess the stability of vitamin content, sensory acceptability and color variation in fortified spaceflight foods over a period of two years. Findings will help to identify optimal formulation, processing, and storage conditions to maintain stability and acceptability of commercially available fortification nutrients. Changes in food quality were monitored to indicate whether fortification affects quality over time (compared to the unfortified control), thus indicating their potential for use on long-duration missions.

Enhancement of the Accelerating Gradient in Superconducting Microwave Resonators

DOE Office of Scientific and Technical Information (OSTI.GOV)

Checchin, Mattia; Grassellino, Anna; Martinello, Martina

2017-05-01

The accelerating gradient of superconducting resonators can be enhanced by engineering the thickness of a dirty layer grown at the cavity's rf surface. In this paper the description of the physics behind the accelerating gradient enhancement by meaning of the dirty layer is carried out by solving numerically the the Ginzburg-Landau (GL) equations for the layered system. The calculation shows that the presence of the dirty layer stabilizes the Meissner state up to the lower critical field of the bulk, increasing the maximum accelerating gradient.

Axisymmetric Tandem Mirrors: Stabilization and Confinement Studies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Post, R.F.; Fowler, T.K.; Bulmer, R.

2005-01-15

The 'Kinetic Stabilizer' has been proposed as a means of MHD stabilizing an axisymmetric tandem mirror system. The K-S concept is based on theoretical studies by Ryutov, confirmed experimentally in the Gas Dynamic Trap experiment in Novosibirsk. In the K-S beams of ions are directed into the end of an 'expander' region outside the outer mirror of a tandem mirror. These ions, slowed, stagnated, and reflected as they move up the magnetic gradient, produce a low-density stabilizing plasma.At the Lawrence Livermore National Laboratory we have been conducting theoretical and computational studies of the K-S Tandem Mirror. These studies have employedmore » a low-beta code written especially to analyze the beam injection/stabilization process,and a new code SYMTRAN (by Hua and Fowler)that solves the coupled radial and axial particle and energy transport in a K-S T-M. Also, a 'legacy' MHD stability code, FLORA, has been upgraded and employed to benchmark the injection/stabilization code and to extend its results to high beta values.The FLORA code studies so far have confirmed the effectiveness of the K-S in stabilizing high-beta (40%) plasmas with stabilizer plasmas the peak pressures of which are several orders of magnitude smaller than those of the confined plasma.Also the SYMTRAN code has shown D-T plasma ignition from alpha particle energy deposition in T-M regimes with strong end plugging.Our studies have confirmed the viability of the K-S T-M concept with respect to MHD stability and radial and axial confinement. We are continuing these studies in order to optimize the parameters and to examine means for the stabilization of possible residual instability modes, such as drift modes and 'trapped-particle' modes. These modes may in principle be controlled by tailoring the stabilizer plasma distribution and/or the radial potential distribution.In the paper the results to date of our studies are summarized and projected to scope out possible fusion-power versions of the

Axisymmetric Tandem Mirrors: Stabilization and Confinement Studies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Post, R F; Fowler, T K; Bulmer, R

2004-07-15

The 'Kinetic Stabilizer' has been proposed as a means of MHD stabilizing an axisymmetric tandem mirror system. The K-S concept is based on theoretical studies by Ryutov, confirmed experimentally in the Gas Dynamic Trap experiment in Novosibirsk. In the K-S beams of ions are directed into the end of an 'expander' region outside the outer mirror of a tandem mirror. These ions, slowed, stagnated, and reflected as they move up the magnetic gradient, produce a low-density stabilizing plasma. At the Lawrence Livermore National Laboratory we have been conducting theoretical and computational studies of the K-S Tandem Mirror. These studies havemore » employed a low-beta code written especially to analyze the beam injection/stabilization process, and a new code SYMTRAN (by Hua and Fowler) that solves the coupled radial and axial particle and energy transport in a K-S TM. Also, a 'legacy' MHD stability code, FLORA, has been upgraded and employed to benchmark the injection/stabilization code and to extend its results to high beta values. The FLORA code studies so far have confirmed the effectiveness of the K-S in stabilizing high-beta (40%) plasmas with stabilizer plasmas the peak pressures of which are several orders of magnitude smaller than those of the confined plasma. Also the SYMTRAN code has shown D-T plasma ignition from alpha particle energy deposition in T-M regimes with strong end plugging. Our studies have confirmed the viability of the K-S-T-M concept with respect to MHD stability and radial and axial confinement. We are continuing these studies in order to optimize the parameters and to examine means for the stabilization of possible residual instability modes, such as drift modes and 'trapped-particle' modes. These modes may in principle be controlled by tailoring the stabilizer plasma distribution and/or the radial potential distribution. In the paper the results to date of our studies are summarized and projected to scope out possible fusion-power versions

Laser acceleration

NASA Astrophysics Data System (ADS)

Tajima, T.; Nakajima, K.; Mourou, G.

2017-02-01

The fundamental idea of Laser Wakefield Acceleration (LWFA) is reviewed. An ultrafast intense laser pulse drives coherent wakefield with a relativistic amplitude robustly supported by the plasma. While the large amplitude of wakefields involves collective resonant oscillations of the eigenmode of the entire plasma electrons, the wake phase velocity ˜ c and ultrafastness of the laser pulse introduce the wake stability and rigidity. A large number of worldwide experiments show a rapid progress of this concept realization toward both the high-energy accelerator prospect and broad applications. The strong interest in this has been spurring and stimulating novel laser technologies, including the Chirped Pulse Amplification, the Thin Film Compression, the Coherent Amplification Network, and the Relativistic Mirror Compression. These in turn have created a conglomerate of novel science and technology with LWFA to form a new genre of high field science with many parameters of merit in this field increasing exponentially lately. This science has triggered a number of worldwide research centers and initiatives. Associated physics of ion acceleration, X-ray generation, and astrophysical processes of ultrahigh energy cosmic rays are reviewed. Applications such as X-ray free electron laser, cancer therapy, and radioisotope production etc. are considered. A new avenue of LWFA using nanomaterials is also emerging.

Accelerated testing for studying pavement design and performance (FY 2002) : performance of foamed asphalt stabilized base in full depth reclaimed asphalt pavement.

DOT National Transportation Integrated Search

2004-08-01

This report covers the Fiscal Year 2002 project conducted at the Accelerated Testing Laboratory at Kansas : State University. The project was selected and funded by the Midwest Accelerated Testing Pooled Fund Program , : which includes Iowa, Kansas, ...

Exploring the Frequency Stability Limits of Whispering Gallery Mode Resonators for Metrological Applications

NASA Technical Reports Server (NTRS)

Chembo, Yanne K.; Baumgartel, Lukas; Grudinin, Ivan; Strekalov, Dmitry; Thompson, Robert; Yu, Nan

2012-01-01

Whispering gallery mode resonators are attracting increasing interest as promising frequency reference cavities. Unlike commonly used Fabry-Perot cavities, however, they are filled with a bulk medium whose properties have a significant impact on the stability of its resonance frequencies. In this context that has to be reduced to a minimum. On the other hand, a small monolithic resonator provides opportunity for better stability against vibration and acceleration. this feature is essential when the cavity operates in a non-laboratory environment. In this paper, we report a case study for a crystalline resonator, and discuss the a pathway towards the inhibition of vibration-and acceleration-induced frequency fluctuations.

Current driven instabilities of an electromagnetically accelerated plasma

NASA Technical Reports Server (NTRS)

Chouetri, E. Y.; Kelly, A. J.; Jahn, R. G.

1988-01-01

A plasma instability that strongly influences the efficiency and lifetime of electromagnetic plasma accelerators was quantitatively measured. Experimental measurements of dispersion relations (wave phase velocities), spatial growth rates, and stability boundaries are reported. The measured critical wave parameters are in excellent agreement with theoretical instability boundary predictions. The instability is current driven and affects a wide spectrum of longitudinal (electrostatic) oscillations. Current driven instabilities, which are intrinsic to the high-current-carrying magnetized plasma of the magnetoplasmadynmic (MPD) accelerator, were investigated with a kinetic theoretical model based on first principles. Analytical limits of the appropriate dispersion relation yield unstable ion acoustic waves for T(i)/T(e) much less than 1 and electron acoustic waves for T(i)/T(e) much greater than 1. The resulting set of nonlinear equations for the case of T(i)/T(e) = 1, of most interest to the MPD thruster Plasma Wave Experiment, was numerically solved to yield a multiparameter set of stability boundaries. Under certain conditions, marginally stable waves traveling almost perpendicular to the magnetic field would travel at a velocity equal to that of the electron current. Such waves were termed current waves. Unstable current waves near the upper stability boundary were observed experimentally and are in accordance with theoretical predictions. This provides unambiguous proof of the existence of such instabilites in electromagnetic plasma accelerators.

FFAGs: Front-end for neutrino factories and medical accelerators

NASA Astrophysics Data System (ADS)

Mori, Yoshiharu

The idea of Fixed Field Alternating Gradient (FFAG) accelerator was originated by different people and groups in the early 1950s. It was independently introduced by Ohkawa [Ohkawa (1953)], Symon et al. [Symon et al. (1956)], and Kolomensky [Kolomensky and Lebedev (1966)] when the strong Alternate Gradient (AG) focusing and the phase stability schemes were applied to particle acceleration. The first FFAG electron model was developed in the MURA accelerator project led by Kerst and Cole in the late 1950s. Since then, they have fabricated several electron models in the early 1960s [Symon et al. (1956)]. However, the studies did not lead to a single practical FFAG accelerator for the following 50 years. Because of the difficulties of treating non-linear magnetic field and RF acceleration for non-relativistic particles, the proton FFAG, especially, was not accomplished until recently. In 2000, the FFAG concept was revived with the world's first proton FFAG (POP) which was developed at KEK [Aiba (2000); Mori (1999)]. Since then, in many places [Berg (2004); Johnstone et al. (2004); Mori (2011); Ruggiero (2004); Trbojevic (2004)], FFAGs have been developed and constructed...

Influence of trace elements on stabilization of aqueous solutions of ascorbic acid.

PubMed

Dolińska, Barbara; Ostróżka-Cieślik, Aneta; Caban, Artur; Rimantas, Klimas; Leszczyńska, Lucyna; Ryszka, Florian

2012-12-01

Together with vitamin C, zinc, selenium, manganese, and magnesium play a vital role in the preservation of organs scheduled for transplantation. In the present study, it is shown that addition of 1 mg/l of these elements influences the stability of 0.3 mM ascorbic acid solutions. The solution's stability was estimated using an accelerated stability test. The concentration of vitamin C was measured using a validated spectrophotometric method, which uses the reduction of 2,6-dichlorophenoloindophenol by ascorbic acid. Elevated temperatures, the factor accelerating substances' decomposition reaction rate, were used in the tests. The research was conducted at two temperatures at intervals of 10 °C: 80 ± 0.1 and 90 ± 0.1 °C. It was stated that the studied substances' decomposition occurred in accordance with the equation for first-order reactions. The function of the logarithmic concentration (log%C) over time was revealed to be rectilinear. This dependence was used to determine the kinetics of decomposition reaction rate parameters. The stabilization of vitamin C solutions was measured as the time in which 10 % of the substance decomposed at 20 and 0 °C. Addition of Se(IV) or Mg(II) ions significantly increase the stability of ascorbic acid solution (∼34 and ∼16 %, respectively), but Zn(II) causes a significant decrease in stability by ∼23 %. Addition of Mn(II) has no significant influence on vitamin C stability.

Physicochemical stability, pharmacokinetic, and biodistribution evaluation of paclitaxel solid dispersion prepared using supercritical antisolvent process.

PubMed

Shanmugam, Srinivasan; Park, Jae-Hyun; Chi, Sang-Cheol; Yong, Chul Soon; Choi, Han-Gon; Woo, Jong Soo

2011-06-01

To investigate the physicochemical stability, pharmacokinetics (PK), and biodistribution of paclitaxel (PTX) from paclitaxel solid dispersion (PSD) prepared by supercritical antisolvent (SAS) process. Physicochemical stability was performed in accelerated (40°C 70 ± 5% RH) and stress (60°C) storage conditions for a period of 6 months and 4 weeks, respectively. PK and biodistribution studies were performed in rats following i.v. administration of PTX equivalent to 6 and 12 mg/kg formulations. Physical stability of PSD showed excellent stability with no recrystallization of the amorphous form. Chemical stability of PSD in terms of % PTX remaining was 98.2 ± 0.6% at 6 months and 97.9 ± 0.3% at 4 weeks of accelerated and stress conditions, respectively. The PK study showed a nonlinear increase in AUC with increasing dose, that is, 100% increase in dose (from 6 to 12 mg/kg) resulted in 405.90% increase in AUC. Unlike PK study, the organ distribution study of PTX from PSD showed linear relationship with dose escalation. The order of organ distribution of PTX from highest to lowest for both PSD and Taxol® was liver>kidney>lung>brain. This study demonstrated excellent physicochemical stability with insight information on the PK and biodistribution of PTX from PSD prepared by SAS process.

The Superconducting Cavity Stabilized Oscillator

NASA Technical Reports Server (NTRS)

Turneaure, J. P.; Buchman, Saps; Lipa, John

1997-01-01

Superconducting Cavity Stabilized Oscillators (SCSOs) have produced the most stable clocks to date for integration times between 10(exp 2) and 10(exp 3) seconds, achieving a fractional frequency stability of 2 x 10(exp -16) for a sampling time of 100 s. The principal contributors to cavity frequency variations are: (1) acceleration effects due to gravity and vibrations; (2) temperature variations; (3) variations in the energy stored in the cavity; and (4) noise introduced by the frequency stabilization circuit. We discuss the prospects for improvements in all these areas for both ground-based and space-based SCSOs, which may lead to SCSOs with fractional frequency stabilities below 10(exp -17). SCSOs of this frequency stability will be useful for testing fundamental physical principles.

Study of the seismic performance of hybrid A-frame micropile/MSE (mechanically stabilized earth) wall

NASA Astrophysics Data System (ADS)

Chen, Yumin; Zhang, Zhichao; Liu, Hanlong

2017-04-01

The Hybrid A-Frame Micropile/MSE (mechanically stabilized earth) Wall suitable for mountain roadways is put forward in this study: a pair of vertical and inclined micropiles goes through the backfill region of a highway MSE Wall from the road surface and are then anchored into the foundation. The pile cap and grade beam are placed on the pile tops, and then a road barrier is connected to the grade beam by connecting pieces. The MSE wall's global stability, local stability and impact resistance of the road barrier can be enhanced simultaneously by this design. In order to validate the serviceability of the hybrid A-frame micropile/MSE wall and the reliability of the numerical method, scale model tests and a corresponding numerical simulation were conducted. Then, the seismic performance of the MSE walls before and after reinforcement with micropiles was studied comparatively through numerical methods. The results indicate that the hybrid A-frame micropile/MSE wall can effectively control earthquake-induced deformation, differential settlement at the road surface, bearing pressure on the bottom and acceleration by means of a rigid-soft combination of micropiles and MSE. The accumulated displacement under earthquakes with amplitude of 0.1‒0.5 g is reduced by 36.3%‒46.5%, and the acceleration amplification factor on the top of the wall is reduced by 13.4%, 15.7% and 19.3% based on 0.1, 0.3 and 0.5 g input earthquake loading, respectively. In addition, the earthquake-induced failure mode of the MSE wall in steep terrain is the sliding of the MSE region along the backslope, while the micropiles effectively control the sliding trend. The maximum earthquake-induced pile bending moment is in the interface between MSE and slope foundation, so it is necessary to strengthen the reinforcement of the pile body in the interface. Hence, it is proven that the hybrid A-frame micropile/MSE wall system has good seismic performance.

Reliability enhancement of Navier-Stokes codes through convergence acceleration

NASA Technical Reports Server (NTRS)

Merkle, Charles L.; Dulikravich, George S.

1995-01-01

Methods for enhancing the reliability of Navier-Stokes computer codes through improving convergence characteristics are presented. The improving of these characteristics decreases the likelihood of code unreliability and user interventions in a design environment. The problem referred to as a 'stiffness' in the governing equations for propulsion-related flowfields is investigated, particularly in regard to common sources of equation stiffness that lead to convergence degradation of CFD algorithms. Von Neumann stability theory is employed as a tool to study the convergence difficulties involved. Based on the stability results, improved algorithms are devised to ensure efficient convergence in different situations. A number of test cases are considered to confirm a correlation between stability theory and numerical convergence. The examples of turbulent and reacting flow are presented, and a generalized form of the preconditioning matrix is derived to handle these problems, i.e., the problems involving additional differential equations for describing the transport of turbulent kinetic energy, dissipation rate and chemical species. Algorithms for unsteady computations are considered. The extension of the preconditioning techniques and algorithms derived for Navier-Stokes computations to three-dimensional flow problems is discussed. New methods to accelerate the convergence of iterative schemes for the numerical integration of systems of partial differential equtions are developed, with a special emphasis on the acceleration of convergence on highly clustered grids.

Significance of acceleration period in a dynamic strength testing study.

PubMed

Chen, W L; Su, F C; Chou, Y L

1994-06-01

The acceleration period that occurs during isokinetic tests may provide valuable information regarding neuromuscular readiness to produce maximal contraction. The purpose of this study was to collect the normative data of acceleration time during isokinetic knee testing, to calculate the acceleration work (Wacc), and to determine the errors (ERexp, ERwork, ERpower) due to ignoring Wacc during explosiveness, total work, and average power measurements. Seven male and 13 female subjects attended the test by using the Cybex 325 system and electronic stroboscope machine for 10 testing speeds (30-300 degrees/sec). A three-way ANOVA was used to assess gender, direction, and speed factors on acceleration time, Wacc, and errors. The results indicated that acceleration time was significantly affected by speed and direction; Wacc and ERexp by speed, direction, and gender; and ERwork and ERpower by speed and gender. The errors appeared to increase when testing the female subjects, during the knee flexion test, or when speed increased. To increase validity in clinical testing, it is important to consider the acceleration phase effect, especially in higher velocity isokinetic testing or for weaker muscle groups.

Local Dynamic Stability Assessment of Motion Impaired Elderly Using Electronic Textile Pants.

PubMed

Liu, Jian; Lockhart, Thurmon E; Jones, Mark; Martin, Tom

2008-10-01

A clear association has been demonstrated between gait stability and falls in the elderly. Integration of wearable computing and human dynamic stability measures into home automation systems may help differentiate fall-prone individuals in a residential environment. The objective of the current study was to evaluate the capability of a pair of electronic textile (e-textile) pants system to assess local dynamic stability and to differentiate motion-impaired elderly from their healthy counterparts. A pair of e-textile pants comprised of numerous e-TAGs at locations corresponding to lower extremity joints was developed to collect acceleration, angular velocity and piezoelectric data. Four motion-impaired elderly together with nine healthy individuals (both young and old) participated in treadmill walking with a motion capture system simultaneously collecting kinematic data. Local dynamic stability, characterized by maximum Lyapunov exponent, was computed based on vertical acceleration and angular velocity at lower extremity joints for the measurements from both e-textile and motion capture systems. Results indicated that the motion-impaired elderly had significantly higher maximum Lyapunov exponents (computed from vertical acceleration data) than healthy individuals at the right ankle and hip joints. In addition, maximum Lyapunov exponents assessed by the motion capture system were found to be significantly higher than those assessed by the e-textile system. Despite the difference between these measurement techniques, attaching accelerometers at the ankle and hip joints was shown to be an effective sensor configuration. It was concluded that the e-textile pants system, via dynamic stability assessment, has the potential to identify motion-impaired elderly.

Study of strength kinetics of sand concrete system of accelerated hardening

NASA Astrophysics Data System (ADS)

Sharanova, A. V.; Lenkova, D. A.; Panfilova, A. D.

2018-04-01

Methods of calorimetric analysis are used to study the dynamics of the hydration processes of concretes with different accelerator contents. The efficiency of the isothermal calorimetry method is shown for study of strength kinetics of concrete mixtures of accelerated hardening, promising for additive technologies in civil engineering.

Physiological Effects of Acceleration Observed During a Centrifuge Study of Pilot Performance

NASA Technical Reports Server (NTRS)

Smedal, Harald A.; Creer, Brent Y.; Wingrove, Rodney C.

1960-01-01

An investigation was conducted by the National Aeronautics and Space Administration, Ames Research Center, and the Naval Air Development Center, Aviation Medical Acceleration Laboratory, to study the effects of acceleration on pilot performance and to obtain some meaningful data for use in establishing tolerance to acceleration levels. The flight simulator used in the study was the Johnsville centrifuge operated as a closed loop system. The pilot was required to perform a control task in various sustained acceleration fields typical of those that Might be encountered by a pilot flying an entry vehicle in which he is seated in a forward-facing position. A special restraint system was developed and designed to increase the pilot's tolerance to these accelerations. The results of this study demonstrated that a well-trained subject, such as a test pilot, can adequately carry out a control task during moderately high accelerations for prolonged periods of time. The maximum levels of acceleration tolerated were approximately 6 times that of gravity for approximately 6 minutes, and varied slightly with the acceleration direction. The tolerance runs were in each case terminated by the subject. In all but two instances, the cause was extreme fatigue. On two occasions the subject terminated the run when he "grayed out." Although there were subjective and objective findings involving the visual and cardiovascular systems, the respiratory system yielded the more critical limiting factors. It would appear that these limiting factors were less severe during the "eyeballs-out" accelerations when compared with the "eyeballs-in" accelerations. These findings are explained on the basis of the influence that the inertial forces of acceleration have on the mechanics of respiration. A condensed version of this report was presented at the Annual Meeting of the Aerospace Medical Association, Miami Beach, May 5-11, 1960, in a paper entitled "Ability of Pilots to Perform a Control Task in

Adaptive control for accelerators

DOEpatents

Eaton, Lawrie E.; Jachim, Stephen P.; Natter, Eckard F.

1991-01-01

An adaptive feedforward control loop is provided to stabilize accelerator beam loading of the radio frequency field in an accelerator cavity during successive pulses of the beam into the cavity. A digital signal processor enables an adaptive algorithm to generate a feedforward error correcting signal functionally determined by the feedback error obtained by a beam pulse loading the cavity after the previous correcting signal was applied to the cavity. Each cavity feedforward correcting signal is successively stored in the digital processor and modified by the feedback error resulting from its application to generate the next feedforward error correcting signal. A feedforward error correcting signal is generated by the digital processor in advance of the beam pulse to enable a composite correcting signal and the beam pulse to arrive concurrently at the cavity.

A study on task difficulty and acceleration stress

NASA Technical Reports Server (NTRS)

Repperger, D. W.; Rogers, D. B.

1981-01-01

The results of two experiments which relate to task difficulty and the effects of environmental stress on tracking performance are discussed and compared to subjective evaluations. The first experiment involved five different sum of sine tracking tasks which humans tracked both in a static condition and under a 5 Gz acceleration stress condition. The second experiment involved similar environmental stress conditions but in this case the tasks were constructed from deterministic functions with specially designed velocity and acceleration profiles. Phase Plane performance analysis was conducted to study potential measures of workload or tracking difficulty.

Acceleration and torque feedback for robotic control - Experimental results

NASA Technical Reports Server (NTRS)

Mclnroy, John E.; Saridis, George N.

1990-01-01

Gross motion control of robotic manipulators typically requires significant on-line computations to compensate for nonlinear dynamics due to gravity, Coriolis, centripetal, and friction nonlinearities. One controller proposed by Luo and Saridis avoids these computations by feeding back joint acceleration and torque. This study implements the controller on a Puma 600 robotic manipulator. Joint acceleration measurement is obtained by measuring linear accelerations of each joint, and deriving a computationally efficient transformation from the linear measurements to the angular accelerations. Torque feedback is obtained by using the previous torque sent to the joints. The implementation has stability problems on the Puma 600 due to the extremely high gains inherent in the feedback structure. Since these high gains excite frequency modes in the Puma 600, the algorithm is modified to decrease the gain inherent in the feedback structure. The resulting compensator is stable and insensitive to high frequency unmodeled dynamics. Moreover, a second compensator is proposed which uses acceleration and torque feedback, but still allows nonlinear terms to be fed forward. Thus, by feeding the increment in the easily calculated gravity terms forward, improved responses are obtained. Both proposed compensators are implemented, and the real time results are compared to those obtained with the computed torque algorithm.

Design of an 81.25 MHz continuous-wave radio-frequency quadrupole accelerator for Low Energy Accelerator Facility

NASA Astrophysics Data System (ADS)

Ma, Wei; Lu, Liang; Xu, Xianbo; Sun, Liepeng; Zhang, Zhouli; Dou, Weiping; Li, Chenxing; Shi, Longbo; He, Yuan; Zhao, Hongwei

2017-03-01

An 81.25 MHz continuous wave (CW) radio frequency quadrupole (RFQ) accelerator has been designed for the Low Energy Accelerator Facility (LEAF) at the Institute of Modern Physics (IMP) of the Chinese Academy of Science (CAS). In the CW operating mode, the proposed RFQ design adopted the conventional four-vane structure. The main design goals are providing high shunt impendence with low power losses. In the electromagnetic (EM) design, the π-mode stabilizing loops (PISLs) were optimized to produce a good mode separation. The tuners were also designed and optimized to tune the frequency and field flatness of the operating mode. The vane undercuts were optimized to provide a flat field along the RFQ cavity. Additionally, a full length model with modulations was set up for the final EM simulations. Following the EM design, thermal analysis of the structure was carried out. In this paper, detailed EM design and thermal simulations of the LEAF-RFQ will be presented and discussed. Structure error analysis was also studied.

Acceleration constraints in modeling and control of nonholonomic systems

NASA Astrophysics Data System (ADS)

Bajodah, Abdulrahman H.

2003-10-01

Acceleration constraints are used to enhance modeling techniques for dynamical systems. In particular, Kane's equations of motion subjected to bilateral constraints, unilateral constraints, and servo-constraints are modified by utilizing acceleration constraints for the purpose of simplifying the equations and increasing their applicability. The tangential properties of Kane's method provide relationships between the holonomic and the nonholonomic partial velocities, and hence allow one to describe nonholonomic generalized active and inertia forces in terms of their holonomic counterparts, i.e., those which correspond to the system without constraints. Therefore, based on the modeling process objectives, the holonomic and the nonholonomic vector entities in Kane's approach are used interchangeably to model holonomic and nonholonomic systems. When the holonomic partial velocities are used to model nonholonomic systems, the resulting models are full-order (also called nonminimal or unreduced) and separated in accelerations. As a consequence, they are readily integrable and can be used for generic system analysis. Other related topics are constraint forces, numerical stability of the nonminimal equations of motion, and numerical constraint stabilization. Two types of unilateral constraints considered are impulsive and friction constraints. Impulsive constraints are modeled by means of a continuous-in-velocities and impulse-momentum approaches. In controlled motion, the acceleration form of constraints is utilized with the Moore-Penrose generalized inverse of the corresponding constraint matrix to solve for the inverse dynamics of servo-constraints, and for the redundancy resolution of overactuated manipulators. If control variables are involved in the algebraic constraint equations, then these tools are used to modify the controlled equations of motion in order to facilitate control system design. An illustrative example of spacecraft stabilization is presented.

Dynamic stabilization of an optomechanical oscillator

DTIC Science & Technology

2014-10-20

respectively. The proper frequency of the pendulum is ω0 = √ g/, where g is the gravitational acceleration and is the length of the pendulum . The...controlled experiments. In this paper we discuss one such situation, the dynamic stabilization of a mechanical system such as an inverted pendulum . The...quantumoptomechanics, macroscopic quantum system, dynamic stabilization, Kapitza pendulum REPORT DOCUMENTATION PAGE 11. SPONSOR/MONITOR’S REPORT NUMBER(S

Stability analysis of unsteady ablation fronts

DOE Office of Scientific and Technical Information (OSTI.GOV)

Betti, R.; McCrory, R.L.; Verdon, C.P.

1993-08-01

The linear stability analysis of unsteady ablation fronts, is carried out for a semi-infinite uniform medium. For a laser accelerated target, it is shown that a properly selected modulation of the laser intensity can lead to the dynamic stabilization or growth-rate reduction of a large portion of the unstable spectrum. The theory is in qualitative agreement with the numerical results obtained by using the two-dimensional hydrodynamic code ORCHID.

Stability analysis of unsteady ablation fronts

DOE Office of Scientific and Technical Information (OSTI.GOV)

Betti, R.; McCrory, R.L.; Verdon, C.P.

1993-11-08

The linear stability analysis of unsteady ablation fronts is carried out for a semi-infinite uniform medium. For a laser accelerated target, it is shown that a properly selected modulation of the laser intensity can lead to the dynamic stabilization or growth-rate reduction of a large portion of the unstable spectrum. The theory is in qualitative agreement with the numerical results obtained by using the two-dimensional hydrodynamic code ORCHID.

The IMISS-1 Experiment for Recording and Analysis of Accelerations in Orbital Flight

NASA Astrophysics Data System (ADS)

Sadovnichii, V. A.; Alexandrov, V. V.; Bugrov, D. I.; Lemak, S. S.; Pakhomov, V. B.; Panasyuk, M. I.; Petrov, V. L.; Yashin, I. V.

2018-03-01

The IMISS-1 experiment represents the second step in solving the problem of the creation of the gaze stabilization corrector. This device is designed to correct the effect of the gaze stabilization delay under microgravity. IMISS-1 continues research started by the Tat'yana-2 satellite. This research will be continued on board the International Space Station. At this stage we study the possibility of registration of angular and linear accelerations acting on the sensitive mass in terms of Low Earth Orbit flight, using MEMS sensors.

The effects of surgical preparation techniques and implant macro-geometry on primary stability: An in vitro study.

PubMed

Falisi, G; Severino, M; Rastelli, C; Bernardi, S; Caruso, S; Galli, M; Lamazza, L; Di Paolo, C

2017-03-01

The attainment of a good primary stability is a necessary condition to ensure the success of osseointegration in implantology. In type IV cancellous bone, however, it is possible that a reduced primary stability can lead to an increased rate of failure. The aim of this study was therefore to determine, with the help of the resonance frequency (Osstell mentor), which technique of implant site preparation (piezo surgery, conventional, under-preparation, bone compaction, osteodistraction) and macro-geometry is able to improve implant stability in type IV cancellous bone. 10 pig ribs were prepared with a surgical pre-drilled guide, calibrated for a correct implant positioning. On each rib, 5 implant sites (one for each technique) were prepared. Successively, 50 conical implants (Tekka Global D) were inserted and measured with the resonance frequency to evaluate the primary stability. Data collected were analyzed by analysis of variance (ANOVA) to test whether the Implant Stability Quotient (ISQ) values of the five techniques were significantly different. The results showed that no significant differences among the ISQ values of the five techniques used were found. Also, no significant differences in the macro-geometry of the two types of compared implants were observed. However, the macro-geometry of Tekka implants, characterized by a double condensing thread, seems to provide greater ISQ values than those of single thread implants when using the same technique. In light of these preliminary data, it is conceivable that in cases of reduced stability, such as those occurring with a type IV bone, all means ameliorating the primary stability and accelerating the osseointegration can be utilized.

Accelerated cure of phenol-formaldehyde resins : studies with model compounds

Treesearch

Anthony H. Conner; Linda F. Lorenz; Kolby C. Hirth

2002-01-01

2-Hydroxymethylphenol (2-HMP) and 4-hydroxymethylphenol (4-HMP) were used as model compounds to study the reactions that occur during cure of phenol-formaldehyde (PF) resin to which cure accelerators (ethyl formate, propylene carbonate, g-butyrolactone, and triacetin) have been added. The addition of cure accelerators significantly increased the rate of condensation...

The progress about measurements of the proton beam characteristics of the JUNA 400 kV accelerator

NASA Astrophysics Data System (ADS)

Wang, Shuo; Li, Kuoang

2018-04-01

China JinPing underground Laboratory (CJPL) was established inside the tunnels piercing Jinping Mountain in Sichuan Province, China, which can provide an ideal environment for low background experiment. Jinping Underground laboratory for Nuclear Astrophysics (JUNA) is one of the major research programs in CJPL. A new 400 kV accelerator, with high current based on an ECR source, will be installed into CJPL for the study of key nuclear reactions in astrophysics. The beam characteristics of the accelerator, like absolute energy, energy spread, and long-term energy stability, will be determined by several well-known resonance and non-resonance reactions. Due to the new accelerator still being under construction, the resonance reaction of 27Al(p, γ)28Si and non-resonance 12C(p, γ)13N were studied at the 320 kV high-voltage platform of Institute of Modern Physics in Lanzhou, China. The energy spread of proton beam is about 1.0 keV and the long-term energy stability of proton beam is better than ±200eV during 4 hours measurement.

Air Cushion Landing System Stability Study.

DTIC Science & Technology

1981-02-01

desirable. A useful result is that the analysis approach employed provides a systematic technique with which a given trunk/vehicle system may be designed ...models. Since for the 48. system analyzed the stability appears better if the side and end elements are truly isolated, the po~zibility of designing a...used to study the stability behavior appears to pro- vide a useful tool for design of systems of this type so that acceptable stability behavior is

The application of electrochemistry to pharmaceutical stability testing--comparison with in silico prediction and chemical forced degradation approaches.

PubMed

Torres, Susana; Brown, Roland; Szucs, Roman; Hawkins, Joel M; Zelesky, Todd; Scrivens, Garry; Pettman, Alan; Taylor, Mark R

2015-11-10

The aim of this study was to evaluate the use of electrochemistry to generate oxidative degradation products of a model pharmaceutical compound. The compound was oxidized at different potentials using an electrochemical flow-cell fitted with a glassy carbon working electrode, a Pd/H2 reference electrode and a titanium auxiliary electrode. The oxidative products formed were identified and structurally characterized by LC-ESI-MS/MS using a high resolution Q-TOF mass spectrometer. Results from electrochemical oxidation using electrolytes of different pH were compared to those from chemical oxidation and from accelerated stability studies. Additionally, oxidative degradation products predicted using an in silico commercially available software were compared to those obtained from the various experimental methods. The electrochemical approach proved to be useful as an oxidative stress test as all of the final oxidation products observed under accelerated stability studies could be generated; previously reported reactive intermediate species were not observed most likely because the electrochemical mechanism differs from the oxidative pathway followed under accelerated stability conditions. In comparison to chemical degradation tests electrochemical degradation has the advantage of being much faster and does not require the use of strong oxidizing agents. Moreover, it enables the study of different operating parameters in short periods of time and optimisation of the reaction conditions (pH and applied potential) to achieve different oxidative products mixtures. This technique may prove useful as a stress test condition for the generation of oxidative degradation products and may help accelerate structure elucidation and development of stability indicating analytical methods. Copyright © 2015 Elsevier B.V. All rights reserved.

HPLC and HPLC/MS/MS Studies on Stress, Accelerated and Intermediate Degradation Tests of Antivirally Active Tricyclic Analog of Acyclovir.

PubMed

Lesniewska, Monika A; Dereziński, Paweł; Klupczyńska, Agnieszka; Kokot, Zenon J; Ostrowski, Tomasz; Zeidler, Joanna; Muszalska, Izabela

2015-01-01

The degradation behavior of a tricyclic analog of acyclovir [6-(4-MeOPh)-TACV] was determined in accordance with International Conference on Harmonization guidelines for good clinical practice under different stress conditions (neutral hydrolysis, strong acid/base degradation, oxidative decomposition, photodegradation, and thermal degradation). Accelerated [40±2°C/75%±5% relative humidity (RH)] and intermediate (30±2°C/65%±5% RH) stability tests were also performed. For observation of the degradation of the tested compound the RP-HPLC was used, whereas for the analysis of its degradation products HPLC/MS/MS was used. Degradation of the tested substance allowed its classification as unstable in neutral environment, acidic/alkaline medium, and in the presence of oxidizing agent. The tested compound was also light sensitive and was classified as photolabile both in solution and in the solid phase. However, the observed photodegradation in the solid phase was at a much lower level than in the case of photodegradation in solution. The study showed that both air temperature and RH had no significant effect on the stability of the tested substance during storage for 1 month at 100°C (dry heat) as well as during accelerated and intermediate tests. Based on the HPLC/MS/MS analysis, it can be concluded that acyclovir was formed as a degradation product of 6-(4-MeOPh)-TACV.

EDITORIAL: Laser and Plasma Accelerators Workshop, Kardamyli, Greece, 2009 Laser and Plasma Accelerators Workshop, Kardamyli, Greece, 2009

NASA Astrophysics Data System (ADS)

Bingham, Bob; Muggli, Patric

2011-01-01

beam self-modulation are presented, showing encouraging results for a first experiment using a compressed 24 GeV CERN PS beam. One of the main challenges with laser wakefields is the control of electron injection. In some experiments involving the bubble regime self-injection occurs naturally. Kneip et al show that the stability of the electron beam with energies close to 1 GeV is correlated with the pointing stability of the laser focal spot and depends on the target alignment. Theory and simulations of self-injection reported by Yi et al demonstrate that there is a minimal expansion rate for efficient self-injection. In contrast to solid target ion acceleration, the electron profile in the bubble regime was shown to be manipulated by rotating the laser polarization. Simulations of self-injection into an expanding bubble are reported by Kalmykov et al with the expanding bubble effectively trapping quiescent electrons. To increase the energy of electrons in the laser wakefield scheme, guiding and injection into plasma channels is important. Andreev et al have studied supershort electron bunches in channels with the view of understanding bunch injection. Modelling of electron acceleration in centimetre long capillary tubes is also necessary for future accelerators and is the main part of the paper by Ferrari et al. One of the applications of short-pulse electron beams is in radiation generation as reported by Karagodsky et al. This is an analogue of a technique pioneered in microwave physics where inverse Compton scattering from an optical Bragg structure generates x-rays with high efficiency. The next workshop will be held on 20-24 June 2011 in Wuzhen, Zhejiang Province of China and the scientific programme will be follow the same model as in 2009.

Stability studies of lincomycin hydrochloride in aqueous solution and intravenous infusion fluids.

PubMed

Czarniak, Petra; Boddy, Michael; Sunderland, Bruce; Hughes, Jeff D

2016-01-01

The purpose of this study was to evaluate the chemical stability of Lincocin(®) (lincomycin hydrochloride) in commonly used intravenous fluids at room temperature (25°C), at accelerated-degradation temperatures and in selected buffer solutions. The stability of Lincocin(®) injection (containing lincomycin 600 mg/2 mL as the hydrochloride) stored at 25°C±0.1°C in sodium lactate (Hartmann's), 0.9% sodium chloride, 5% glucose, and 10% glucose solutions was investigated over 31 days. Forced degradation of Lincocin(®) in hydrochloric acid, sodium hydroxide, and hydrogen peroxide was performed at 60°C. The effect of pH on the degradation rate of lincomycin hydrochloride stored at 80°C was determined. Lincomycin hydrochloride w as found to maintain its shelf life at 25°C in sodium lactate (Hartmann's) solution, 0.9% sodium chloride solution, 5% glucose solution, and 10% glucose solution, with less than 5% lincomycin degradation occurring in all intravenous solutions over a 31-day period. Lincomycin hydrochloride showed less rapid degradation at 60°C in acid than in basic solution, but degraded rapidly in hydrogen peroxide. At all pH values tested, lincomycin followed first-order kinetics. It had the greatest stability near pH 4 when stored at 80°C (calculated shelf life of 4.59 days), and was least stable at pH 2 (calculated shelf life of 0.38 days). Lincocin(®) injection was chemically found to have a shelf life of at least 31 days at 25°C when added to sodium lactate (Hartmann's) solution, 0.9% sodium chloride solution, 5% glucose solution, and 10% glucose solution. Solutions prepared at approximately pH 4 are likely to have optimum stability.

Bleaching agent action on color stability, surface roughness and microhardness of composites submitted to accelerated artificial aging.

PubMed

Rattacaso, Raphael Mendes Bezerra; da Fonseca Roberti Garcia, Lucas; Aguilar, Fabiano Gamero; Consani, Simonides; de Carvalho Panzeri Pires-de-Souza, Fernanda

2011-04-01

The purpose of this study was to evaluate the bleaching agent action on color stability, surface roughness and microhardness of composites (Charisma, Filtek Supreme and Heliomolar - A2) submitted to accelerated artificial aging (AAA). A Teflon matrix (12 x 2 mm) was used to fabricate 18 specimens (n=6) which, after polishing (Sof-Lex), were submitted to initial color reading (ΔE), Knoop microhardness (KHN) (50 g/15 s load) and roughness (R(a)) (cut-off 0.25 mm) tests. Afterwards, the samples were submitted to AAA for 384 hours and new color, microhardness and roughness readings were performed. After this, the samples were submitted to daily application (4 weeks) of 16% Carbamide Peroxide (NiteWhite ACP) for 8 hours and kept in artificial saliva for 16 hours. New color, microhardness and roughness readings were made at the end of the cycle, and 15 days after bleaching. Comparison of the ΔE means (2-way ANOVA, Bonferroni, P<.05) indicated clinically unacceptable color alteration for all composites after AAA, but without significant difference. Statistically significant increase in the KHN values after AAA was observed, but without significant alterations 15 days after bleaching. For R(a) there was no statistically significant difference after AAA and 15 days after bleaching. The alterations promoted by the bleaching agent and AAA are material dependent.

A Study of Longitudinal Control Problems at Low and Negative Damping and Stability with Emphasis on Effects of Motion Cues

NASA Technical Reports Server (NTRS)

Sadoff, Melvin; McFadden, Norman M.; Heinle, Donovan R.

1961-01-01

As part of a general investigation to determine the effects of simulator motions on pilot opinion and task performance over a wide range of vehicle longitudinal dynamics, a cooperative NASA-AMAL program was conducted on the centrifuge at Johnsville, Pennsylvania. The test parameters and measurements for this program duplicated those of earlier studies made at Ames Research Center with a variable-stability airplane and with a pitch-roll chair flight simulator. Particular emphasis was placed on the minimum basic damping and stability the pilots would accept and on the minimum dynamics they considered controllable in the event of stability-augmentation system failure. Results of the centrifuge-simulator program indicated that small positive damping was required by the pilots over most of the frequency range covered for configurations rated acceptable for emergency conditions only (e.g., failure of a pitch damper). It was shown that the pilot's tolerance for unstable dynamics was dependent primarily on the value of damping. For configurations rated acceptable for emergency operation only, the allowable instability and damping corresponded to a divergence time to double amplitude of about 1 second. Comparisons were made of centrifuge, pitch-chair and fixed-cockpit simulator tests with flight tests. Pilot ratings indicated that the effects of incomplete or spurious motion cues provided by these three modes of simulation were important only for high-frequency, lightly damped dynamics or unstable, moderately damped dynamics. The pitch- chair simulation, which provided accurate angular-acceleration cues to the pilot, compared most favorably with flight. For the centrifuge simulation, which furnished accurate normal accelerations but spurious pitching and longitudinal accelerations, there was a deterioration of pilots' opinion relative to flight results. Results of simulator studies with an analog pilot replacing the human pilot illustrated the adaptive capability of human

Interface behavior of a multi-layer fluid configuration subject to acceleration in a microgravity environment, supplement 1. M.S. Thesis

NASA Technical Reports Server (NTRS)

Lyell, M. J.; Roh, Michael

1991-01-01

With the increasing opportunities for research in a microgravity environment, there arises a need for understanding fluid mechanics under such conditions. In particular, a number of material processing configurations involve fluid-fluid interfaces which may experience instabilities in the presence of external forcing. In a microgravity environment, these accelerations may be periodic or impulse-type in nature. This research investigates the behavior of a multi-layer idealized fluid configuration which is infinite in extent. The analysis is linear, and each fluid region is considered inviscid, incompressible, and immiscible. An initial parametric study of confiquration stability in the presence of a constant acceleration field is performed. The zero mean gravity limit case serves as the base state for the subsequent time-dependent forcing cases. A stability analysis of the multi-layer fluid system in the presence of periodic forcing is investigated. Floquet theory is utilized. A parameter study is performed, and regions of stability are identified. For the impulse-type forcing case, asymptotic stability is established for the configuration. Using numerical integration, the time response of the interfaces is determined.

Influence of finishing/polishing on color stability and surface roughness of composites submitted to accelerated artificial aging.

PubMed

Pinto, Gustavo Da Col dos Santos; Dias, Kleber Campioni; Cruvinel, Diogo Rodrigues; Garcia, Lucas da Fonseca Roberti; Consani, Simonides; Pires-De-Souza, Fernanda de Carvalho Panzeri

2013-01-01

To assess the influence of finishing/polishing procedure on color stability (ΔE ) and surface roughness (R(a)) of composites (Heliomolar and Tetric - color A2) submitted to accelerated artificial aging (AAA). Sixty test specimens were made of each composite (12 mm × 2 mm) and separated into six groups (n = 10), according to the type of finishing/polishing to which they were submitted: C, control; F, tip 3195 F; FF, tip 3195 FF; FP, tip 3195 F + diamond paste; FFP, tip 3195 FF + diamond paste; SF, Sof-Lex discs. After polishing, controlled by an electromechanical system, initial color (spectrophotometer PCB 6807 BYK GARDNER) and R(a) (roughness meter Surfcorder SE 1700, cut-off 0.25 mm) readings were taken. Next, the test specimens were submitted to the AAA procedure (C-UV Comexim) for 384 hours, and at the end of this period, new color readings and R(a) were taken. Statistical analysis [2-way analysis of variance (ANOVA), Bonferroni, P < 0.05] showed that all composites demonstrated ΔE alteration above the clinically acceptable limits, with the exception of Heliomolar composite in FP. The greatest ΔE alteration occurred for Tetric composite in SF (13.38 ± 2.10) statistically different from F and FF (P < 0.05). For R(a), Group F showed rougher samples than FF with statistically significant difference (P < 0.05). In spite of the surface differences, the different finishing/polishing procedures were not capable of providing color stability within the clinically acceptable limits.

Kinematic variability, fractal dynamics and local dynamic stability of treadmill walking

PubMed Central

2011-01-01

Background Motorized treadmills are widely used in research or in clinical therapy. Small kinematics, kinetics and energetics changes induced by Treadmill Walking (TW) as compared to Overground Walking (OW) have been reported in literature. The purpose of the present study was to characterize the differences between OW and TW in terms of stride-to-stride variability. Classical (Standard Deviation, SD) and non-linear (fractal dynamics, local dynamic stability) methods were used. In addition, the correlations between the different variability indexes were analyzed. Methods Twenty healthy subjects performed 10 min TW and OW in a random sequence. A triaxial accelerometer recorded trunk accelerations. Kinematic variability was computed as the average SD (MeanSD) of acceleration patterns among standardized strides. Fractal dynamics (scaling exponent α) was assessed by Detrended Fluctuation Analysis (DFA) of stride intervals. Short-term and long-term dynamic stability were estimated by computing the maximal Lyapunov exponents of acceleration signals. Results TW did not modify kinematic gait variability as compared to OW (multivariate T2, p = 0.87). Conversely, TW significantly modified fractal dynamics (t-test, p = 0.01), and both short and long term local dynamic stability (T2 p = 0.0002). No relationship was observed between variability indexes with the exception of significant negative correlation between MeanSD and dynamic stability in TW (3 × 6 canonical correlation, r = 0.94). Conclusions Treadmill induced a less correlated pattern in the stride intervals and increased gait stability, but did not modify kinematic variability in healthy subjects. This could be due to changes in perceptual information induced by treadmill walking that would affect locomotor control of the gait and hence specifically alter non-linear dependencies among consecutive strides. Consequently, the type of walking (i.e. treadmill or overground) is important to consider in each protocol

Initiation of combustion in the thermally choked ram accelerator

NASA Technical Reports Server (NTRS)

Bruckner, A. P.; Burnham, E. A.; Knowlen, C.; Hertzberg, A.; Bogdanoff, D. W.

1992-01-01

The methodology for initiating stable combustion in a ram accelerator operating in the thermally choked mode is presented in this paper. The ram accelerator is a high velocity ramjet-in-tube projectile launcher whose principle of operation is similar to that of an airbreathing ramjet. The subcaliber projectile travels supersonically through a stationary tube filled with a premixed combustible gas mixture. In the thermally choked propulsion mode subsonic combustion takes place behind the base of the projectile and leads to thermal choking, which stabilizes a normal shock system on the projectile, thus producing forward thrust. Projectiles with masses in the 45-90 g range have been accelerated to velocities up to 2650 m/sec in a 38 mm bore, 16 m long accelerator tube. Operation of the ram accelerator is started by injecting the projectile into the accelerator tube at velocities in the 700 - 1300 m/sec range by means of a conventional gas gun. A specially designed obturator, which seals the bore of the gun during this initial acceleration, enters the ram accelerator together with the projectile. The interaction of the obturator with the propellant gas ignites the gas mixture and establishes stable combustion behind the projectile.

Method for Studying Helicopter Longitudinal Maneuver Stability

NASA Technical Reports Server (NTRS)

Amer, Kenneth B

1954-01-01

A theoretical analysis of helicopter maneuver stability is made and the results are compared with experimental results for both a single and a tandem rotor helicopter. Techniques are described for measuring in flight the significant stability derivatives for use with the theory to aid in design studies of means for achieving marginal maneuver stability for a prototype helicopter.

High-throughput metabolic stability studies in drug discovery by orthogonal acceleration time-of-flight (OATOF) with analogue-to-digital signal capture (ADC).

PubMed

Temesi, David G; Martin, Scott; Smith, Robin; Jones, Christopher; Middleton, Brian

2010-06-30

Screening assays capable of performing quantitative analysis on hundreds of compounds per week are used to measure metabolic stability during early drug discovery. Modern orthogonal acceleration time-of-flight (OATOF) mass spectrometers equipped with analogue-to-digital signal capture (ADC) now offer performance levels suitable for many applications normally supported by triple quadruple instruments operated in multiple reaction monitoring (MRM) mode. Herein the merits of MRM and OATOF with ADC detection are compared for more than 1000 compounds screened in rat and/or cryopreserved human hepatocytes over a period of 3 months. Statistical comparison of a structurally diverse subset indicated good agreement for the two detection methods. The overall success rate was higher using OATOF detection and data acquisition time was reduced by around 20%. Targeted metabolites of diazepam were detected in samples from a CLint determination performed at 1 microM. Data acquisition by positive and negative ion mode switching can be achieved on high-performance liquid chromatography (HPLC) peak widths as narrow as 0.2 min (at base), thus enabling a more comprehensive first pass analysis with fast HPLC gradients. Unfortunately, most existing OATOF instruments lack the software tools necessary to rapidly convert the huge amounts of raw data into quantified results. Software with functionality similar to open access triple quadrupole systems is needed for OATOF to truly compete in a high-throughput screening environment. Copyright 2010 John Wiley & Sons, Ltd.

Spin Stabilized Impulsively Controlled Missile (SSICM)

NASA Astrophysics Data System (ADS)

Crawford, J. I.; Howell, W. M.

1985-12-01

This patent is for the Spin Stabilized Impulsively Controlled Missile (SSICM). SSICM is a missile configuration which employs spin stabilization, nutational motion, and impulsive thrusting, and a body mounted passive or semiactive sensor to achieve very small miss distances against a high speed moving target. SSICM does not contain an autopilot, control surfaces, a control actuation system, nor sensor stabilization gimbals. SSICM spins at a rate sufficient to provide frequency separation between body motions and inertial target motion. Its impulsive thrusters provide near instantaneous changes in lateral velocity, whereas conventional missiles require a significant time delay to achieve lateral acceleration.

Accelerated in vitro release testing method for naltrexone loaded PLGA microspheres.

PubMed

Andhariya, Janki V; Choi, Stephanie; Wang, Yan; Zou, Yuan; Burgess, Diane J; Shen, Jie

2017-03-30

The objective of the present study was to develop a discriminatory and reproducible accelerated release testing method for naltrexone loaded parenteral polymeric microspheres. The commercially available naltrexone microsphere product (Vivitrol ® ) was used as the testing formulation in the in vitro release method development, and both sample-and-separate and USP apparatus 4 methods were investigated. Following an in vitro drug stability study, frequent media replacement and addition of anti-oxidant in the release medium were used to prevent degradation of naltrexone during release testing at "real-time" (37°C) and "accelerated" (45°C), respectively. The USP apparatus 4 method was more reproducible than the sample-and-separate method. In addition, the accelerated release profile obtained using USP apparatus 4 had a shortened release duration (within seven days), and good correlation with the "real-time" release profile. Lastly, the discriminatory ability of the developed accelerated release method was assessed using compositionally equivalent naltrexone microspheres with different release characteristics. The developed accelerated USP apparatus 4 release method was able to detect differences in the release characteristics of the prepared naltrexone microspheres. Moreover, a linear correlation was observed between the "real-time" and accelerated release profiles of all the formulations investigated, suggesting that the release mechanism(s) may be similar under both conditions. These results indicate that the developed accelerated USP apparatus 4 method has the potential to be an appropriate fast quality control tool for long-acting naltrexone PLGA microspheres. Copyright © 2017 Elsevier B.V. All rights reserved.

Social-emotional characteristics of gifted accelerated and non-accelerated students in the Netherlands.

PubMed

Hoogeveen, Lianne; van Hell, Janet G; Verhoeven, Ludo

2012-12-01

In the studies of acceleration conducted so far a multidimensional perspective has largely been neglected. No attempt has been made to relate social-emotional characteristics of accelerated versus non-accelerated students in perspective of environmental factors. In this study, social-emotional characteristics of accelerated gifted students in the Netherlands were examined in relation to personal and environmental factors. Self-concept and social contacts of accelerated (n = 148) and non-accelerated (n = 55) gifted students, aged 4 to 27 (M = 11.22, SD = 4.27) were measured. Self-concept and social contacts of accelerated and non-accelerated gifted students were measured using a questionnaire and a diary, and parents of these students evaluated their behavioural characteristics. Gender and birth order were studied as personal factors and grade, classroom, teachers' gender, teaching experience, and the quality of parent-school contact as environmental factors. The results showed minimal differences in the social-emotional characteristics of accelerated and non-accelerated gifted students. The few differences we found favoured the accelerated students. We also found that multiple grade skipping does not have negative effects on social-emotional characteristics, and that long-term effects of acceleration tend to be positive. As regards the possible modulation of personal and environmental factors, we merely found an impact of such factors in the non-accelerated group. The results of this study strongly suggest that social-emotional characteristics of accelerated gifted students and non-accelerated gifted students are largely similar. These results thus do not support worries expressed by teachers about the acceleration of gifted students. Our findings parallel the outcomes of earlier studies in the United States and Germany in that we observed that acceleration does not harm gifted students, not even in the case of multiple grade skipping. On the contrary, there is a

The effects of surgical preparation techniques and implant macro-geometry on primary stability: An in vitro study

PubMed Central

Severino, Marco; Rastelli, Claudio; Bernardi, Sara; Caruso, Silvia; Galli, Massimo; Lamazza, Luca; Di Paolo, Carlo

2017-01-01

Background The attainment of a good primary stability is a necessary condition to ensure the success of osseointegration in implantology. In type IV cancellous bone, however, it is possible that a reduced primary stability can lead to an increased rate of failure. The aim of this study was therefore to determine, with the help of the resonance frequency (Osstell mentor), which technique of implant site preparation (piezo surgery, conventional, under-preparation, bone compaction, osteodistraction) and macro-geometry is able to improve implant stability in type IV cancellous bone. Material and Methods 10 pig ribs were prepared with a surgical pre-drilled guide, calibrated for a correct implant positioning. On each rib, 5 implant sites (one for each technique) were prepared. Successively, 50 conical implants (Tekka Global D) were inserted and measured with the resonance frequency to evaluate the primary stability. Data collected were analyzed by analysis of variance (ANOVA) to test whether the Implant Stability Quotient (ISQ) values of the five techniques were significantly different. Results The results showed that no significant differences among the ISQ values of the five techniques used were found. Also, no significant differences in the macro-geometry of the two types of compared implants were observed. However, the macro-geometry of Tekka implants, characterized by a double condensing thread, seems to provide greater ISQ values than those of single thread implants when using the same technique. Conclusions In light of these preliminary data, it is conceivable that in cases of reduced stability, such as those occurring with a type IV bone, all means ameliorating the primary stability and accelerating the osseointegration can be utilized. Key words:Implant primary stability, resonance frequency analysis, implant site preparation. PMID:28160577

Navigating in foldonia: Using accelerated molecular dynamics to explore stability, unfolding and self-healing of the β-solenoid structure formed by a silk-like polypeptide

PubMed Central

Zhao, Binwu

2017-01-01

The β roll molecules with sequence (GAGAGAGQ)10 stack via hydrogen bonding to form fibrils which have been themselves been used to make viral capsids of DNA strands, supramolecular nanotapes and pH-responsive gels. Accelerated molecular dynamics (aMD) simulations are used to investigate the unfolding of a stack of two β roll molecules, (GAGAGAGQ)10, to shed light on the folding mechanism by which silk-inspired polypeptides form fibrils and to identify the dominant forces that keep the silk-inspired polypeptide in a β roll configuration. Our study shows that a molecule in a stack of two β roll molecules unfolds in a step-wise fashion mainly from the C terminal. The bottom template is found to play an important role in stabilizing the β roll structure of the molecule on top by strengthening the hydrogen bonds in the layer that it contacts. Vertical hydrogen bonds within the β roll structure are considerably weaker than lateral hydrogen bonds, signifying the importance of lateral hydrogen bonds in stabilizing the β roll structure. Finally, an intermediate structure was found containing a β hairpin and an anti-parallel β sheet consisting of strands from the top and bottom molecules, revealing the self-healing ability of the β roll stack. PMID:28329017

Experimental Investigation of Hexagon Stability in Two Frequency Forced Faraday Waves

NASA Astrophysics Data System (ADS)

Ding, Yu; Umbanhowar, Paul

2003-03-01

We have conducted experiments on a deep layer of silicone oil vertically oscillated with an acceleration a(t) = Am sin(m ω t + φ_m) + An sin(n ω t + φ_n). The stability of hexagonal surface wave patterns is investigated as a function of the overall acceleration, the ratio m:n, and the phase of the two rationally related driving frequencies. When the ratio A_m/An is chosen so the system is near a co-dimension two point, the stability of hexagons above onset is determined by the acceleration amplitude and the relative phase. Recent results by Porter and Silver (J. Porter and M. Silber, Phys. Rev. Lett. 084501, 2002) predicts that the range of pattern stability above onset as a function of acceleration is determined by cos(Φ), where Φ = π/4 - m φn / 2- n φm /2. We have tested this prediction for a number of m:n ratios and for various values of the dimensionless damping coefficient γ. We find that the patterns exhibit the predicted functional dependence on s(Φ) but with an additional phase offset. We measure the phase offset as a function of m:n and γ for varying frequency ω and fluid viscosity 5 cS <= ν <= 30 cS.

Evaluation of stone/RAP interlayers under accelerated loading : tech summary.

DOT National Transportation Integrated Search

2008-08-01

The first Louisiana accelerated loading experiment, Evaluation of Louisianas Conventional and Alternative Base Courses, showed that pavement performance could be enhanced signifi cantly if a layer of stone was placed over the cement stabilized sub...

Evaluation of stone/RAP interlayers under accelerated loading : tech summary.

DOT National Transportation Integrated Search

2008-08-01

The fi rst Louisiana accelerated loading experiment, Evaluation of Louisianas Conventional and Alternative Base Courses, : showed that pavement performance could be enhanced signifi cantly if a layer of stone was placed over the cement : stabilize...

A new concept of a vacuum insulation tandem accelerator.

PubMed

Sorokin, I; Taskaev, S

2015-12-01

A tandem accelerator with vacuum insulation has been proposed and developed in the Budker Institute of Nuclear Physics. Negative hydrogen ions are accelerated by the positive 1 MV potential of the high voltage electrode, converted into protons in the gas stripping target inside the electrode, and then the protons are accelerated again by the same potential. The potential for high voltage and intermediate electrodes is supplied by the sectioned rectifier through a sectioned bushing insulator with a resistive divider. In this work, we propose a radical improvement of the accelerator concept. It is proposed to abandon the separate placement of the accelerator and the power supply and connect them through the bushing insulator. The source of high voltage is proposed to be located inside the accelerator insulator with high voltage and intermediate electrodes mounted on it. This will reduce the facility height from 7 m to 3m and make it really compact and attractive for placing in a clinic. This will significantly increase the stability of the accelerator because the potential for intermediate electrodes can be fed directly from the relevant sections of the rectifier. Copyright © 2015 Elsevier Ltd. All rights reserved.

Ground Motion Studies for Large Future Accelerator

NASA Astrophysics Data System (ADS)

Takeda, Shigeru; Oide, Katsunobu

1997-05-01

The future large accelerator, such as TeV linear collider, should have extremely small emittance to perform the required luminosity. Precise alignment of machine components is essential to prevent emittance dilution. The ground motion spoils alignment of accelerator elements and results in emittance growth. The ground motion in the frequency range of seismic vibration is mostly coherent in the related accelerator. But the incoherent diffusive or Brownian like motion becomes dominant at frequency region less than seismic vibration [1, 2, 3]. Slow ground motion with respect to the machine performance is discussed including the method of tunnel construction. Our experimental results and recent excavated results clarify that application of TBMs is better excavating method than NATM (Drill + Blast) for accelerator tunnel to prevent emittance dilution. ([1] V. Shiltsev, Proc. of IWAA95 Tsukuba, 1995. [2] Shigeru Takeda et al., Proc. of EPAC96, 1996. [3] A. Sery, Proc. of LINAC96, 1996.)

Stabilized floating platforms

DOEpatents

Thomas, David G.

1976-01-01

The subject invention is directed to a floating platform for supporting nuclear reactors and the like at selected offshore sites. The platform is provided with a stabilizer mechanism which significantly reduces the effects of wave action upon the platform and which comprises a pair of relatively small floats attached by rigid booms to the platform at locations spaced therefrom for reducing wave pitch, acceleration, and the resonance period of the wave.

Analytical Approaches for Identification and Representation of Critical Protection Systems in Transient Stability Studies

NASA Astrophysics Data System (ADS)

Hedman, Mojdeh Khorsand

After a major disturbance, the power system response is highly dependent on protection schemes and system dynamics. Improving power systems situational awareness requires proper and simultaneous modeling of both protection schemes and dynamic characteristics in power systems analysis tools. Historical information and ex-post analysis of blackouts reaffirm the critical role of protective devices in cascading events, thereby confirming the necessity to represent protective functions in transient stability studies. This dissertation is aimed at studying the importance of representing protective relays in power system dynamic studies. Although modeling all of the protective relays within transient stability studies may result in a better estimation of system behavior, representing, updating, and maintaining the protection system data becomes an insurmountable task. Inappropriate or outdated representation of the relays may result in incorrect assessment of the system behavior. This dissertation presents a systematic method to determine essential relays to be modeled in transient stability studies. The desired approach should identify protective relays that are critical for various operating conditions and contingencies. The results of the transient stability studies confirm that modeling only the identified critical protective relays is sufficient to capture system behavior for various operating conditions and precludes the need to model all of the protective relays. Moreover, this dissertation proposes a method that can be implemented to determine the appropriate location of out-of-step blocking relays. During unstable power swings, a generator or group of generators may accelerate or decelerate leading to voltage depression at the electrical center along with generator tripping. This voltage depression may cause protective relay mis-operation and unintentional separation of the system. In order to avoid unintentional islanding, the potentially mis-operating relays

Lattice design of the integrable optics test accelerator and optical stochastic cooling experiment at Fermilab

NASA Astrophysics Data System (ADS)

Kafka, Gene

The Integrable Optics Test Accelerator (IOTA) storage ring at Fermilab will serve as the backbone for a broad spectrum of Advanced Accelerator R&D (AARD) experiments, and as such, must be designed with significant flexibility in mind, but without compromising cost efficiency. The nonlinear experiments at IOTA will include: achievement of a large nonlinear tune shift/spread without degradation of dynamic aperture; suppression of strong lattice resonances; study of stability of nonlinear systems to perturbations; and studies of different variants of nonlinear magnet design. The ring optics control has challenging requirements that reach or exceed the present state of the art. The development of a complete self-consistent design of the IOTA ring optics, meeting the demands of all planned AARD experiments, is presented. Of particular interest are the precise control for nonlinear integrable optics experiments and the transverse-to-longitudinal coupling and phase stability for the Optical Stochastic Cooling Experiment (OSC). Since the beam time-of-flight must be tightly controlled in the OSC section, studies of second order corrections in this section are presented.

EDITORIAL: Laser and plasma accelerators Laser and plasma accelerators

NASA Astrophysics Data System (ADS)

Bingham, Robert

2009-02-01

This special issue on laser and plasma accelerators illustrates the rapid advancement and diverse applications of laser and plasma accelerators. Plasma is an attractive medium for particle acceleration because of the high electric field it can sustain, with studies of acceleration processes remaining one of the most important areas of research in both laboratory and astrophysical plasmas. The rapid advance in laser and accelerator technology has led to the development of terawatt and petawatt laser systems with ultra-high intensities and short sub-picosecond pulses, which are used to generate wakefields in plasma. Recent successes include the demonstration by several groups in 2004 of quasi-monoenergetic electron beams by wakefields in the bubble regime with the GeV energy barrier being reached in 2006, and the energy doubling of the SLAC high-energy electron beam from 42 to 85 GeV. The electron beams generated by the laser plasma driven wakefields have good spatial quality with energies ranging from MeV to GeV. A unique feature is that they are ultra-short bunches with simulations showing that they can be as short as a few femtoseconds with low-energy spread, making these beams ideal for a variety of applications ranging from novel high-brightness radiation sources for medicine, material science and ultrafast time-resolved radiobiology or chemistry. Laser driven ion acceleration experiments have also made significant advances over the last few years with applications in laser fusion, nuclear physics and medicine. Attention is focused on the possibility of producing quasi-mono-energetic ions with energies ranging from hundreds of MeV to GeV per nucleon. New acceleration mechanisms are being studied, including ion acceleration from ultra-thin foils and direct laser acceleration. The application of wakefields or beat waves in other areas of science such as astrophysics and particle physics is beginning to take off, such as the study of cosmic accelerators considered

Surface effects on dynamic stability and loading during outdoor running using wireless trunk accelerometry.

PubMed

Schütte, Kurt H; Aeles, Jeroen; De Beéck, Tim Op; van der Zwaard, Babette C; Venter, Rachel; Vanwanseele, Benedicte

2016-07-01

Despite frequently declared benefits of using wireless accelerometers to assess running gait in real-world settings, available research is limited. The purpose of this study was to investigate outdoor surface effects on dynamic stability and dynamic loading during running using tri-axial trunk accelerometry. Twenty eight runners (11 highly-trained, 17 recreational) performed outdoor running on three outdoor training surfaces (concrete road, synthetic track and woodchip trail) at self-selected comfortable running speeds. Dynamic postural stability (tri-axial acceleration root mean square (RMS) ratio, step and stride regularity, sample entropy), dynamic loading (impact and breaking peak amplitudes and median frequencies), as well as spatio-temporal running gait measures (step frequency, stance time) were derived from trunk accelerations sampled at 1024Hz. Results from generalized estimating equations (GEE) analysis showed that compared to concrete road, woodchip trail had several significant effects on dynamic stability (higher AP ratio of acceleration RMS, lower ML inter-step and inter-stride regularity), on dynamic loading (downward shift in vertical and AP median frequency), and reduced step frequency (p<0.05). Surface effects were unaffected when both running level and running speed were added as potential confounders. Results suggest that woodchip trails disrupt aspects of dynamic stability and loading that are detectable using a single trunk accelerometer. These results provide further insight into how runners adapt their locomotor biomechanics on outdoor surfaces in situ. Copyright © 2016 Elsevier B.V. All rights reserved.

Heavy ion linear accelerator for radiation damage studies of materials

NASA Astrophysics Data System (ADS)

Kutsaev, Sergey V.; Mustapha, Brahim; Ostroumov, Peter N.; Nolen, Jerry; Barcikowski, Albert; Pellin, Michael; Yacout, Abdellatif

2017-03-01

A new eXtreme MATerial (XMAT) research facility is being proposed at Argonne National Laboratory to enable rapid in situ mesoscale bulk analysis of ion radiation damage in advanced materials and nuclear fuels. This facility combines a new heavy-ion accelerator with the existing high-energy X-ray analysis capability of the Argonne Advanced Photon Source. The heavy-ion accelerator and target complex will enable experimenters to emulate the environment of a nuclear reactor making possible the study of fission fragment damage in materials. Material scientists will be able to use the measured material parameters to validate computer simulation codes and extrapolate the response of the material in a nuclear reactor environment. Utilizing a new heavy-ion accelerator will provide the appropriate energies and intensities to study these effects with beam intensities which allow experiments to run over hours or days instead of years. The XMAT facility will use a CW heavy-ion accelerator capable of providing beams of any stable isotope with adjustable energy up to 1.2 MeV/u for 238U50+ and 1.7 MeV for protons. This energy is crucial to the design since it well mimics fission fragments that provide the major portion of the damage in nuclear fuels. The energy also allows damage to be created far from the surface of the material allowing bulk radiation damage effects to be investigated. The XMAT ion linac includes an electron cyclotron resonance ion source, a normal-conducting radio-frequency quadrupole and four normal-conducting multi-gap quarter-wave resonators operating at 60.625 MHz. This paper presents the 3D multi-physics design and analysis of the accelerating structures and beam dynamics studies of the linac.

Heavy ion linear accelerator for radiation damage studies of materials

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kutsaev, Sergey V.; Mustapha, Brahim; Ostroumov, Peter N.

A new eXtreme MATerial (XMAT) research facility is being proposed at Argonne National Laboratory to enable rapid in situ mesoscale bulk analysis of ion radiation damage in advanced materials and nuclear fuels. This facility combines a new heavy-ion accelerator with the existing high-energy X-ray analysis capability of the Argonne Advanced Photon Source. The heavy-ion accelerator and target complex will enable experimenters to emulate the environment of a nuclear reactor making possible the study of fission fragment damage in materials. Material scientists will be able to use the measured material parameters to validate computer simulation codes and extrapolate the response ofmore » the material in a nuclear reactor environment. Utilizing a new heavy-ion accelerator will provide the appropriate energies and intensities to study these effects with beam intensities which allow experiments to run over hours or days instead of years. The XMAT facility will use a CW heavy-ion accelerator capable of providing beams of any stable isotope with adjustable energy up to 1.2 MeV/u for U-238(50+) and 1.7 MeV for protons. This energy is crucial to the design since it well mimics fission fragments that provide the major portion of the damage in nuclear fuels. The energy also allows damage to be created far from the surface of the material allowing bulk radiation damage effects to be investigated. The XMAT ion linac includes an electron cyclotron resonance ion source, a normal-conducting radio-frequency quadrupole and four normal-conducting multi-gap quarter-wave resonators operating at 60.625 MHz. This paper presents the 3D multi-physics design and analysis of the accelerating structures and beam dynamics studies of the linac.« less

Study of Car Acceleration and Deceleration Characteristics at Dangerous Route FT050

NASA Astrophysics Data System (ADS)

Omar, N.; Prasetijo, J.; Daniel, B. D.; Abdullah, M. A. E.; Ismail, I.

2018-04-01

Individual vehicle acceleration and deceleration are important to generate vehicles speed profile. This study covered acceleration and deceleration characteristics of passenger car in Federal Route FT050 Jalan Batu Pahat-Ayer Hitam that was the top ranking dangerous road. Global Positioning System was used to record 10 cars speed to develop speed profile with clustering zone. At the acceleration manoeuver, the acceleration rate becomes lower as the drivers get near to desired speed. While, at deceleration manoeuver, vehicles with high speed needs more time to stop compare to low speed vehicle. This is because, the drivers need to accelerate more from zero speed to achieve desired speed and drivers need more distance and time to stop their vehicles. However, it was found out that 30% to 50% are driving in dangerous condition that was proven in clustering acceleration and deceleration speed profile. As conclusion, this excessive drivers are the factor that creating high risk in rear-end collision that inline FT050 as dangerous road in Malaysia

Scaling fixed-field alternating gradient accelerators with a small orbit excursion.

PubMed

Machida, Shinji

2009-10-16

A novel scaling type of fixed-field alternating gradient (FFAG) accelerator is proposed that solves the major problems of conventional scaling and nonscaling types. This scaling FFAG accelerator can achieve a much smaller orbit excursion by taking a larger field index k. A triplet focusing structure makes it possible to set the operating point in the second stability region of Hill's equation with a reasonable sensitivity to various errors. The orbit excursion is about 5 times smaller than in a conventional scaling FFAG accelerator and the beam size growth due to typical errors is at most 10%.

Plasma Wakefield Acceleration of an Intense Positron Beam

DOE Office of Scientific and Technical Information (OSTI.GOV)

Blue, B

2004-04-21

The Plasma Wakefield Accelerator (PWFA) is an advanced accelerator concept which possess a high acceleration gradient and a long interaction length for accelerating both electrons and positrons. Although electron beam-plasma interactions have been extensively studied in connection with the PWFA, very little work has been done with respect to positron beam-plasma interactions. This dissertation addresses three issues relating to a positron beam driven plasma wakefield accelerator. These issues are (a) the suitability of employing a positron drive bunch to excite a wake; (b) the transverse stability of the drive bunch; and (c) the acceleration of positrons by the plasma wakemore » that is driven by a positron bunch. These three issues are explored first through computer simulations and then through experiments. First, a theory is developed on the impulse response of plasma to a short drive beam which is valid for small perturbations to the plasma density. This is followed up with several particle-in-cell (PIC) simulations which study the experimental parameter (bunch length, charge, radius, and plasma density) range. Next, the experimental setup is described with an emphasis on the equipment used to measure the longitudinal energy variations of the positron beam. Then, the transverse dynamics of a positron beam in a plasma are described. Special attention is given to the way focusing, defocusing, and a tilted beam would appear to be energy variations as viewed on our diagnostics. Finally, the energy dynamics imparted on a 730 {micro}m long, 40 {micro}m radius, 28.5 GeV positron beam with 1.2 x 10{sup 10} particles in a 1.4 meter long 0-2 x 10{sup 14} e{sup -}/cm{sup 3} plasma is described. First the energy loss was measured as a function of plasma density and the measurements are compared to theory. Then, an energy gain of 79 {+-} 15 MeV is shown. This is the first demonstration of energy gain of a positron beam in a plasma and it is in good agreement with the

Photon bubbles and ion acceleration in a plasma dominated by the radiation pressure of an electromagnetic pulse.

PubMed

Pegoraro, F; Bulanov, S V

2007-08-10

The stability of a thin plasma foil accelerated by the radiation pressure of a high intensity electromagnetic (e.m.) pulse is investigated analytically and with particle in cell numerical simulations. It is shown that the onset of a Rayleigh-Taylor-like instability can lead to transverse bunching of the foil and to broadening of the energy spectrum of fast ions. The use of a properly tailored e.m. pulse with a sharp intensity rise can stabilize the foil acceleration.

Identifying head-trunk and lower limb contributions to gaze stabilization during locomotion

NASA Technical Reports Server (NTRS)

Mulavara, Ajitkumar P.; Bloomberg, Jacob J.

2002-01-01

The goal of the present study was to determine how the multiple, interdependent full-body sensorimotor subsystems respond to a change in gaze stabilization task constraints during locomotion. Nine subjects performed two gaze stabilization tasks while walking at 6.4 km/hr on a motorized treadmill: 1) focusing on a central point target; 2) reading numeral characters; both presented at 2 m in front at the level of their eyes. While subjects performed the tasks we measured: temporal parameters of gait, full body sagittal plane segmental kinematics of the head, trunk, thigh, tibia and foot, accelerations along the vertical axis at the head and the tibia, and the vertical forces acting on the support surface. We tested the hypothesis that with the increased demands placed on visual acuity during the number recognition task, subjects would modify full-body segmental kinematics in order to reduce perturbations to the head in order to successfully perform the task. We found that while reading numeral characters as compared to the central point target: 1) compensatory head pitch movement was on average 22% greater despite the fact that the trunk pitch and trunk vertical translation movement control were not significantly changed; 2) coordination patterns between head and trunk as reflected by the peak cross correlation between the head pitch and trunk pitch motion as well as the peak cross correlation between the head pitch and vertical trunk translation motion were not significantly changed; 3) knee joint total movement was on average 11% greater during the period from the heel strike event to the peak knee flexion event in stance phase of the gait cycle; 4) peak acceleration measured at the head was significantly reduced by an average of 13% in four of the six subjects. This was so even when the peak acceleration at the tibia and the transmission of the shock wave at heel strike (measured by the peak acceleration ratio of the head/tibia and the time lag between the tibial

Current Fragmentation and Particle Acceleration in Solar Flares

NASA Astrophysics Data System (ADS)

Cargill, P. J.; Vlahos, L.; Baumann, G.; Drake, J. F.; Nordlund, Å.

2012-11-01

Particle acceleration in solar flares remains an outstanding problem in plasma physics and space science. While the observed particle energies and timescales can perhaps be understood in terms of acceleration at a simple current sheet or turbulence site, the vast number of accelerated particles, and the fraction of flare energy in them, defies any simple explanation. The nature of energy storage and dissipation in the global coronal magnetic field is essential for understanding flare acceleration. Scenarios where the coronal field is stressed by complex photospheric motions lead to the formation of multiple current sheets, rather than the single monolithic current sheet proposed by some. The currents sheets in turn can fragment into multiple, smaller dissipation sites. MHD, kinetic and cellular automata models are used to demonstrate this feature. Particle acceleration in this environment thus involves interaction with many distributed accelerators. A series of examples demonstrate how acceleration works in such an environment. As required, acceleration is fast, and relativistic energies are readily attained. It is also shown that accelerated particles do indeed interact with multiple acceleration sites. Test particle models also demonstrate that a large number of particles can be accelerated, with a significant fraction of the flare energy associated with them. However, in the absence of feedback, and with limited numerical resolution, these results need to be viewed with caution. Particle in cell models can incorporate feedback and in one scenario suggest that acceleration can be limited by the energetic particles reaching the condition for firehose marginal stability. Contemporary issues such as footpoint particle acceleration are also discussed. It is also noted that the idea of a "standard flare model" is ill-conceived when the entire distribution of flare energies is considered.

ACCELERATION AND ENRICHMENT IN THE JUNIOR HIGH SCHOOL. A FOLLOW-UP STUDY.

ERIC Educational Resources Information Center

ARENDS, RICHARD H.; FORD, PAUL M.

THE 1963-64 STUDY INVOLVED AN INVESTIGATION OF ACCELERATION IN MATHEMATICS AND ENRICHMENT IN READING AND SCIENCE IN THE JUNIOR HIGH SCHOOL. BUT THE RESEARCH WAS BROADENED AND, UNLIKE THE 1962-63 STUDY, EXPLORED MORE DEEPLY THE EFFECTS OF ACCELERATION AND ENRICHMENT. A NUMBER OF SCHOOLS OUTSIDE OF WALLA WALLA WAS USED. PROBLEMS CONSIDERED WERE--(1)…

Probing electron acceleration and x-ray emission in laser-plasma accelerators

DOE Office of Scientific and Technical Information (OSTI.GOV)

Thaury, C.; Ta Phuoc, K.; Corde, S.

2013-06-15

While laser-plasma accelerators have demonstrated a strong potential in the acceleration of electrons up to giga-electronvolt energies, few experimental tools for studying the acceleration physics have been developed. In this paper, we demonstrate a method for probing the acceleration process. A second laser beam, propagating perpendicular to the main beam, is focused on the gas jet few nanosecond before the main beam creates the accelerating plasma wave. This second beam is intense enough to ionize the gas and form a density depletion, which will locally inhibit the acceleration. The position of the density depletion is scanned along the interaction lengthmore » to probe the electron injection and acceleration, and the betatron X-ray emission. To illustrate the potential of the method, the variation of the injection position with the plasma density is studied.« less

Comparison of bile salt/phosphatidylcholine mixed micelles in solubilization to sterols and stability.

PubMed

Guo, Qin; Cai, Jie; Li, Pengyu; Xu, Dongling; Ni, Xiaomin; Wen, Hui; Liu, Dan; Lin, Suizhen; Hu, Haiyan

2016-01-01

Androst-3β,5α,6β-triol (Triol) is a promising neuroprotective agent, but its poor solubility restricts its development into parenteral preparations. In this study, Triol is significantly solubilized by bile salt/phosphatidylcholine mixed micelles (BS/PC-MM). All BS/PC-MM systems are tested to remarkably improve the drug solubility with various stabilities after drug loading. Among them, the sodium glycocholate (SGC)/egg phosphatidylcholine (EPC) system with 2:1 ratio in weight and the total concentration of SGC and EPC of 100 mg/mL is proved to produce stable mixed micelles with high drug loading. It is found that the stability of drug-loaded mixed micelles is quite different, which might be related to the change in critical micelle concentration (CMC) after incorporating drugs. SGC/EPC and SGC/soya phosphatidylcholine (SPC) remain transparent under accelerated conditions and manifest a decreased CMC (dropping from 0.105 to 0.056 mg/mL and from 0.067 to 0.024 mg/mL, respectively). In contrast, swine bile acid-sodium salt (SBA-Na)/PC and sodium deoxycholate (SDC)/PC are accompanied by drug precipitation and reached the maximum CMC on the first and the third days, respectively. Interestingly, the variation of CMC under accelerated testing conditions highly matches the drug-precipitating event in the primary stability experiment. In brief, the bile salt/phosphatidylcholine system exists as a potential strategy of improving sterol drug solubility. CMC variation under accelerated testing conditions might be a simple and easy method to predict the stability of drug-loaded mixed micelles.

The effect of platelet-rich fibrin on implant stability.

PubMed

Öncü, Elif; Alaaddinoğlu, E Emine

2015-01-01

Achieving accelerated implant osseointegration could make immediate or early loading of implants more predictable. Platelet-rich fibrin (PRF) is frequently used to accelerate soft and hard tissue healing. The activated platelets in PRF release growth factors, resulting in cellular proliferation, collagen synthesis, and osteoid production. The aim of this study was to compare the stability of dental implants inserted in a one-stage surgical protocol with or without PRF application. Twenty healthy patients with adequate alveolar bone and two or more adjacent missing teeth extracted at least 6 months previously were included in this study. A minimum of two tapered implants (Ankylos, Dentsply/Friadent) were placed in each patient. After surgical preparation of the implant sockets, PRF that had been prepared preoperatively was placed randomly into one of the sockets (PRF+). The acellular plasma portion of PRF was used to wet the implant placed into the PRF-coated socket. Resonance frequency measurements were made after implant placement and at 1 week and 1 month postoperatively. Mean implant stability quotients (ISQs) of the PRF+ implants was 69.3 ± 10.5, and mean ISQs for the PRF- implants was 64.5 ± 12.2 at the end of the first week. The mean ISQs at 4 weeks postoperatively were 77.1 ± 7.1 for the PRF+ group and 70.5 ± 7.7 for the PRF- group. In this study, PRF application increased implant stability during the early healing period, as evidenced by higher ISQ values. Simple application of this material seems to provide faster osseointegration.

Impact of excipient interactions on solid dosage form stability.

PubMed

Narang, Ajit S; Desai, Divyakant; Badawy, Sherif

2012-10-01

Drug-excipient interactions in solid dosage forms can affect drug product stability in physical aspects such as organoleptic changes and dissolution slowdown, or chemically by causing drug degradation. Recent research has allowed the distinction in chemical instability resulting from direct drug-excipient interactions and from drug interactions with excipient impurities. A review of chemical instability in solid dosage forms highlights common mechanistic themes applicable to multiple degradation pathways. These common themes include the role of water and microenvironmental pH. In addition, special aspects of solid-state reactions with excipients and/or excipient impurities add to the complexity in understanding and modeling reaction pathways. This paper discusses mechanistic basis of known drug-excipient interactions with case studies and provides an overview of common underlying themes. Recent developments in the understanding of degradation pathways further impact methodologies used in the pharmaceutical industry for prospective stability assessment. This paper discusses these emerging aspects in terms of limitations of drug-excipient compatibility studies, emerging paradigms in accelerated stability testing, and application of mathematical modeling for prediction of drug product stability.

Nonlocal Galileons and self-acceleration

NASA Astrophysics Data System (ADS)

Gabadadze, Gregory; Yu, Siqing

2017-05-01

A certain class of nonlocal theories eliminates an arbitrary cosmological constant (CC) from a universe that can be perceived as our world. Dark energy then cannot be explained by a CC; it could however be due to massive gravity. We calculate the new corrections, which originate from the nonlocal terms that eliminate the CC, to the decoupling limit Lagrangian of massive gravity. The new nonlocal terms also have internal field space Galilean symmetry and are referred here as ;nonlocal Galileons.; We then study a self-accelerated solution and show that the new nonlocal terms change the perturbative stability analysis. In particular, small fluctuations are now stable and non-superluminal for some simple parameter choices, whereas for the same choices the pure massive gravity fluctuations are unstable. We also study stable spherically symmetric solutions on this background.

DIFFUSIVE PARTICLE ACCELERATION IN SHOCKED, VISCOUS ACCRETION DISKS: GREEN'S FUNCTION ENERGY DISTRIBUTION

DOE Office of Scientific and Technical Information (OSTI.GOV)

Becker, Peter A.; Das, Santabrata; Le, Truong, E-mail: pbecker@gmu.edu, E-mail: sbdas@iitg.ernet.in, E-mail: truong.le@nhrec.org

2011-12-10

The acceleration of relativistic particles in a viscous accretion disk containing a standing shock is investigated as a possible explanation for the energetic outflows observed around radio-loud black holes. The energy/space distribution of the accelerated particles is computed by solving a transport equation that includes the effects of first-order Fermi acceleration, bulk advection, spatial diffusion, and particle escape. The velocity profile of the accreting gas is described using a model for shocked viscous disks recently developed by the authors, and the corresponding Green's function distribution for the accelerated particles in the disk and the outflow is obtained using a classicalmore » method based on eigenfunction analysis. The accretion-driven, diffusive shock acceleration scenario explored here is conceptually similar to the standard model for the acceleration of cosmic rays at supernova-driven shocks. However, in the disk application, the distribution of the accelerated particles is much harder than would be expected for a plane-parallel shock with the same compression ratio. Hence the disk environment plays a key role in enhancing the efficiency of the shock acceleration process. The presence of the shock helps to stabilize the disk by reducing the Bernoulli parameter, while channeling the excess binding energy into the escaping relativistic particles. In applications to M87 and Sgr A*, we find that the kinetic power in the jet is {approx}0.01 M-dot c{sup 2}, and the outflowing relativistic particles have a mean energy {approx}300 times larger than that of the thermal gas in the disk at the shock radius. Our results suggest that a standing shock may be an essential ingredient in accretion onto underfed black holes, helping to resolve the long-standing problem of the stability of advection-dominated accretion disks.« less

Modelling third harmonic ion cyclotron acceleration of deuterium beams for JET fusion product studies experiments

NASA Astrophysics Data System (ADS)

Schneider, M.; Johnson, T.; Dumont, R.; Eriksson, J.; Eriksson, L.-G.; Giacomelli, L.; Girardo, J.-B.; Hellsten, T.; Khilkevitch, E.; Kiptily, V. G.; Koskela, T.; Mantsinen, M.; Nocente, M.; Salewski, M.; Sharapov, S. E.; Shevelev, A. E.; Contributors, JET

2016-11-01

Recent JET experiments have been dedicated to the studies of fusion reactions between deuterium (D) and Helium-3 (3He) ions using neutral beam injection (NBI) in synergy with third harmonic ion cyclotron radio-frequency heating (ICRH) of the beam. This scenario generates a fast ion deuterium tail enhancing DD and D3He fusion reactions. Modelling and measuring the fast deuterium tail accurately is essential for quantifying the fusion products. This paper presents the modelling of the D distribution function resulting from the NBI+ICRF heating scheme, reinforced by a comparison with dedicated JET fast ion diagnostics, showing an overall good agreement. Finally, a sawtooth activity for these experiments has been observed and interpreted using SPOT/RFOF simulations in the framework of Porcelli’s theoretical model, where NBI+ICRH accelerated ions are found to have a strong stabilizing effect, leading to monster sawteeth.

Stability analysis in tachyonic potential chameleon cosmology

DOE Office of Scientific and Technical Information (OSTI.GOV)

Farajollahi, H.; Salehi, A.; Tayebi, F.

2011-05-01

We study general properties of attractors for tachyonic potential chameleon scalar-field model which possess cosmological scaling solutions. An analytic formulation is given to obtain fixed points with a discussion on their stability. The model predicts a dynamical equation of state parameter with phantom crossing behavior for an accelerating universe. We constrain the parameters of the model by best fitting with the recent data-sets from supernovae and simulated data points for redshift drift experiment generated by Monte Carlo simulations.

Acceleration Modes and Transitions in Pulsed Plasma Accelerators

NASA Technical Reports Server (NTRS)

Polzin, Kurt A.; Greve, Christine M.

2018-01-01

Pulsed plasma accelerators typically operate by storing energy in a capacitor bank and then discharging this energy through a gas, ionizing and accelerating it through the Lorentz body force. Two plasma accelerator types employing this general scheme have typically been studied: the gas-fed pulsed plasma thruster and the quasi-steady magnetoplasmadynamic (MPD) accelerator. The gas-fed pulsed plasma accelerator is generally represented as a completely transient device discharging in approximately 1-10 microseconds. When the capacitor bank is discharged through the gas, a current sheet forms at the breech of the thruster and propagates forward under a j (current density) by B (magnetic field) body force, entraining propellant it encounters. This process is sometimes referred to as detonation-mode acceleration because the current sheet representation approximates that of a strong shock propagating through the gas. Acceleration of the initial current sheet ceases when either the current sheet reaches the end of the device and is ejected or when the current in the circuit reverses, striking a new current sheet at the breech and depriving the initial sheet of additional acceleration. In the quasi-steady MPD accelerator, the pulse is lengthened to approximately 1 millisecond or longer and maintained at an approximately constant level during discharge. The time over which the transient phenomena experienced during startup typically occur is short relative to the overall discharge time, which is now long enough for the plasma to assume a relatively steady-state configuration. The ionized gas flows through a stationary current channel in a manner that is sometimes referred to as the deflagration-mode of operation. The plasma experiences electromagnetic acceleration as it flows through the current channel towards the exit of the device. A device that had a short pulse length but appeared to operate in a plasma acceleration regime different from the gas-fed pulsed plasma

Convergence acceleration of the Proteus computer code with multigrid methods

NASA Technical Reports Server (NTRS)

Demuren, A. O.; Ibraheem, S. O.

1992-01-01

Presented here is the first part of a study to implement convergence acceleration techniques based on the multigrid concept in the Proteus computer code. A review is given of previous studies on the implementation of multigrid methods in computer codes for compressible flow analysis. Also presented is a detailed stability analysis of upwind and central-difference based numerical schemes for solving the Euler and Navier-Stokes equations. Results are given of a convergence study of the Proteus code on computational grids of different sizes. The results presented here form the foundation for the implementation of multigrid methods in the Proteus code.

Anderson acceleration and application to the three-temperature energy equations

NASA Astrophysics Data System (ADS)

An, Hengbin; Jia, Xiaowei; Walker, Homer F.

2017-10-01

The Anderson acceleration method is an algorithm for accelerating the convergence of fixed-point iterations, including the Picard method. Anderson acceleration was first proposed in 1965 and, for some years, has been used successfully to accelerate the convergence of self-consistent field iterations in electronic-structure computations. Recently, the method has attracted growing attention in other application areas and among numerical analysts. Compared with a Newton-like method, an advantage of Anderson acceleration is that there is no need to form the Jacobian matrix. Thus the method is easy to implement. In this paper, an Anderson-accelerated Picard method is employed to solve the three-temperature energy equations, which are a type of strong nonlinear radiation-diffusion equations. Two strategies are used to improve the robustness of the Anderson acceleration method. One strategy is to adjust the iterates when necessary to satisfy the physical constraint. Another strategy is to monitor and, if necessary, reduce the matrix condition number of the least-squares problem in the Anderson-acceleration implementation so that numerical stability can be guaranteed. Numerical results show that the Anderson-accelerated Picard method can solve the three-temperature energy equations efficiently. Compared with the Picard method without acceleration, Anderson acceleration can reduce the number of iterations by at least half. A comparison between a Jacobian-free Newton-Krylov method, the Picard method, and the Anderson-accelerated Picard method is conducted in this paper.

Accelerated loading evaluation of stabilized BCS layers in pavement performance.

DOT National Transportation Integrated Search

2012-03-01

BCS is short for blended calcium sulfate, a recycled fluorogypsum mixture that has been used in Louisiana as a roadway base for more than a decade. : Without further chemical stabilization, the major concern of using raw BCS as a pavement structural ...

Statistical evaluation for stability studies under stress storage conditions.

PubMed

Gil-Alegre, M E; Bernabeu, J A; Camacho, M A; Torres-Suarez, A I

2001-11-01

During the pharmaceutical development of a new drug, it is necessary to select as soon as possible the formulation with the best stability characteristics. The current International Commission for Harmonisation (ICH) regulations regarding stability testing requirements for a Registration Application provide the stress testing conditions with the aim of assessing the effect of severe conditions on the drug product. In practice, the well-known Arrhenius theory is still used to make a rapid stability prediction, to estimate a drug product shelf life during early stages of its pharmaceutical development. In this work, both the planning of a stress stability study to obtain a correct stability prediction from a temperature extrapolation and the suitable data treatment to discern the reliability of the stability results are discussed. The study was focused on the early formulation step of a very stable drug, Mitonafide (antineoplastic agent), formulated in a parenteral solution and in tablets. It was observed, for the solid system, that the extrapolated results using Arrhenius theory might be statistically good, but far from the real situation if the stability study is not designed in a correct way. The statistical data treatment and the stress-stability test proposed in this work are suitable to make a reliable stability prediction of different formulations with the same drug, within its pharmaceutical development.

Experimental study for the reproduction of sudden unintended acceleration incidents.

PubMed

Park, Sungji; Choi, Youngsuk; Choi, Woongchul

2016-10-01

A few cases of the sudden unintended acceleration have been reported over the last few years [1-11] and some of them seemed to be somewhat related to an electronic throttle control (ETC) system [11,12]. In this experimental study, efforts were made to reproduce the cases of sudden unintended acceleration possibly related to the ETC. Typically, an ETC of the engine is managed based on signals from airflow sensor, throttle position sensor and acceleration pedal sensor. With this typical sensor configuration in mind, these sensor signals were checked for noise levels. However, none of them showed any clear relationship with the sudden unintended acceleration mainly due to the robustness of the ETC logic software. As an alternative approach, supply voltage to an engine control unit (ECU) was tempered intentionally to observe any clues for the incidents. The observed results with the supply voltage drop and fluctuation tests were rather astonishing. The throttle valve position went all the way up to 100% for around one second when the battery voltage plunged down to 7V periodically despite that the acceleration pedal position was kept steady. As an effort to confirm the case, multiple tries were made systematically on a chassis dynamometer as well as on the test road. In this paper, detailed procedures and findings are reported accordingly. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Harmonic ratcheting for fast acceleration

NASA Astrophysics Data System (ADS)

Cook, N.; Brennan, J. M.; Peggs, S.

2014-04-01

A major challenge in the design of rf cavities for the acceleration of medium-energy charged ions is the need to rapidly sweep the radio frequency over a large range. From low-power medical synchrotrons to high-power accelerator driven subcritical reactor systems, and from fixed focus alternating gradient accelerators to rapid cycling synchrotrons, there is a strong need for more efficient, and faster, acceleration of protons and light ions in the semirelativistic range of hundreds of MeV/u. A conventional way to achieve a large, rapid frequency sweep (perhaps over a range of a factor of 6) is to use custom-designed ferrite-loaded cavities. Ferrite rings enable the precise tuning of the resonant frequency of a cavity, through the control of the incremental permeability that is possible by introducing a pseudoconstant azimuthal magnetic field. However, rapid changes over large permeability ranges incur anomalous behavior such as the "Q-loss" and "f-dot" loss phenomena that limit performance while requiring high bias currents. Notwithstanding the incomplete understanding of these phenomena, they can be ameliorated by introducing a "harmonic ratcheting" acceleration scheme in which two or more rf cavities take turns accelerating the beam—one turns on when the other turns off, at different harmonics—so that the radio frequency can be constrained to remain in a smaller range. Harmonic ratcheting also has straightforward performance advantages, depending on the particular parameter set at hand. In some typical cases it is possible to halve the length of the cavities, or to double the effective gap voltage, or to double the repetition rate. This paper discusses and quantifies the advantages of harmonic ratcheting in general. Simulation results for the particular case of a rapid cycling medical synchrotron ratcheting from harmonic number 9 to 2 show that stability and performance criteria are met even when realistic engineering details are taken into consideration.

Oxidative stability of refined olive and sunflower oils supplemented with lycopene-rich oleoresin from tomato peels industrial by-product, during accelerated shelf-life storage.

PubMed

Kehili, Mouna; Choura, Sirine; Zammel, Ayachi; Allouche, Noureddine; Sayadi, Sami

2018-04-25

Tomato peels by-product from a Tunisian industry was used for the extraction of lycopene-rich oleoresin using hexane solvent maceration. Tomato peels oleoresin, TPO, exhibited competitive free radicals scavenging activity with synthetic antioxidants. The efficacy of TPO in stabilizing refined olive (ROO) and sunflower (RSO) oils was investigated for five months, under accelerated shelf-life, compared to the synthetic antioxidant, butylated hydroxytoluene (BHT). TPO was added to ROO and RSO at four different concentrations, namely 250, 500, 1000 and 2000 µg/g and BHT standard at 200 µg/g. Lipid oxidation was tracked by measuring the peroxide value, acidity, conjugated dienes and trienes. Results suggested the highest efficiency of 250 µg/g and 2000 µg/g of TPO, referring to 5 µg/g and 40 µg/g of lycopene, for the oxidative stabilization of ROO and RSO, respectively. The protective effect of TPO against the primary oxidation of these refined oils was significantly correlated to their lycopene contents. Copyright © 2017 Elsevier Ltd. All rights reserved.

An ion beam facility based on a 3 MV tandetron accelerator in Sichuan University, China

NASA Astrophysics Data System (ADS)

Han, Jifeng; An, Zhu; Zheng, Gaoqun; Bai, Fan; Li, Zhihui; Wang, Peng; Liao, Xiaodong; Liu, Mantian; Chen, Shunli; Song, Mingjiang; Zhang, Jun

2018-03-01

A new ion beam facility based on a 3 MV tandetron accelerator system has been installed in Sichuan University, China. The facility was developed by High Voltage Engineering Europa and consists of three high-energy beam lines including the ion beam analysis, ion implantation and nuclear physics experiment end stations, respectively. The terminal voltage stability of the accelerator is better than ±30 V, and the brightness of the proton beam is approximately 5.06 A/rad2/m2/eV. The system demonstrates a great application potential in fields such as nuclear, material and environmental studies.

Basic and applied studies of the ram accelerator as a hypervelocity projectile launcher

NASA Astrophysics Data System (ADS)

Bruckner, Adam P.; Knowlen, Carl

1993-12-01

The potential of using ram accelerator technology for an impulsive launcher of autonomously guided interceptors, such as the LEAP, has been studied during this contract period. In addition, fundamental investigations on some of the engineering issues which must be addressed for enabling ram accelerator propulsive modes to operate at 4 km/sec have been undertaken. An experimental investigation of the gas dynamic limits of ram accelerator operation has demonstrated the existence of two distinct limiting mechanisms that must be accounted for when designing projectiles for these launchers. Other experiments were conducted to make detailed pressure measurements of the flow fields at the tube walls to study the effects of projectile canting. Results from this LEAP launcher study and the experimental investigations indicate that the ram accelerator technology is well suited for applications as a transportable launcher capable of meeting the needs of theater ballistic missile defense missions.

Beam dynamics and electromagnetic studies of a 3 MeV, 325 MHz radio frequency quadrupole accelerator

NASA Astrophysics Data System (ADS)

Gaur, Rahul; Kumar, Vinit

2018-05-01

We present the beam dynamics and electromagnetic studies of a 3 MeV, 325 MHz H- radio frequency quadrupole (RFQ) accelerator for the proposed Indian Spallation Neutron Source project. We have followed a design approach, where the emittance growth and the losses are minimized by keeping the tune depression ratio larger than 0.5. The transverse cross-section of RFQ is designed at a frequency lower than the operating frequency, so that the tuners have their nominal position inside the RFQ cavity. This has resulted in an improvement of the tuning range, and the efficiency of tuners to correct the field errors in the RFQ. The vane-tip modulations have been modelled in CST-MWS code, and its effect on the field flatness and the resonant frequency has been studied. The deterioration in the field flatness due to vane-tip modulations is reduced to an acceptable level with the help of tuners. Details of the error study and the higher order mode study along with mode stabilization technique are also described in the paper.

FAST/Polar Conjunction Study of Field-Aligned Auroral Acceleration and Corresponding Magnetotail Drivers

NASA Technical Reports Server (NTRS)

Schriver, D.; Ashour-Abdalla, M.; Strangeway, R. J.; Richard, R. L.; Klezting, C.; Dotan, Y.; Wygant, J.

2002-01-01

The discrete aurora results when energized electrons bombard the Earth's atmosphere at high latitudes. This paper examines the physical processes that can cause field-aligned acceleration of plasma particles in the auroral region. A data and theoretical study has been carried out to examine the acceleration mechanisms that operate in the auroral zone and to identity the magnetospheric drivers of these acceleration mechanisms. The observations used in the study were collected by the Fast Auroral SnapshoT (FAST) and Polar satellites when the two satellites were in approximate magnetic conjunction in the auroral region. During these events FAST was in the middle of the auroral zone and Polar was above the auroral zone in the near-Earth plasma sheet. Polar data was used to determine the conditions in the magnetotail at the time field-aligned acceleration was measured by FAST in the auroral zone. For each of the magnetotail drivers identified in the data study, the physics of field-aligned acceleration in the auroral region was examined using existing theoretical efforts and a long-system particle-in-cell simulation to model the magnetically connected region between the two satellites.

Electron-beam dynamics for an advanced flash-radiography accelerator

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ekdahl, Carl August Jr.

2015-06-22

Beam dynamics issues were assessed for a new linear induction electron accelerator. Special attention was paid to equilibrium beam transport, possible emittance growth, and beam stability. Especially problematic would be high-frequency beam instabilities that could blur individual radiographic source spots, low-frequency beam motion that could cause pulse-to-pulse spot displacement, and emittance growth that could enlarge the source spots. Beam physics issues were examined through theoretical analysis and computer simulations, including particle-in cell (PIC) codes. Beam instabilities investigated included beam breakup (BBU), image displacement, diocotron, parametric envelope, ion hose, and the resistive wall instability. Beam corkscrew motion and emittance growth frommore » beam mismatch were also studied. It was concluded that a beam with radiographic quality equivalent to the present accelerators at Los Alamos will result if the same engineering standards and construction details are upheld.« less

Accelerated curing and strength-modulus correlation for lime-stabilized soils : final report, January 2010.

DOT National Transportation Integrated Search

2010-01-01

This study sought to identify the equivalent 105F curing duration for lime-stabilized soil (LSS) that will : yield the equivalent unconfined compressive strength (UCS) to that resulting from 28-day, 73F curing. Both : 5-day and 7-day 105F (or 1...

Neck Strength Imbalance Correlates With Increased Head Acceleration in Soccer Heading

PubMed Central

Dezman, Zachary D.W.; Ledet, Eric H.; Kerr, Hamish A.

2013-01-01

Background: Soccer heading is using the head to directly contact the ball, often to advance the ball down the field or score. It is a skill fundamental to the game, yet it has come under scrutiny. Repeated subclinical effects of heading may compound over time, resulting in neurologic deficits. Greater head accelerations are linked to brain injury. Developing an understanding of how the neck muscles help stabilize and reduce head acceleration during impact may help prevent brain injury. Hypothesis: Neck strength imbalance correlates to increasing head acceleration during impact while heading a soccer ball. Study Design: Observational laboratory investigation. Methods: Sixteen Division I and II collegiate soccer players headed a ball in a controlled indoor laboratory setting while player motions were recorded by a 14-camera Vicon MX motion capture system. Neck flexor and extensor strength of each player was measured using a spring-type clinical dynamometer. Results: Players were served soccer balls by hand at a mean velocity of 4.29 m/s (±0.74 m/s). Players returned the ball to the server using a heading maneuver at a mean velocity of 5.48 m/s (±1.18 m/s). Mean neck strength difference was positively correlated with angular head acceleration (rho = 0.497; P = 0.05), with a trend toward significance for linear head acceleration (rho = 0.485; P = 0.057). Conclusion: This study suggests that symmetrical strength in neck flexors and extensors reduces head acceleration experienced during low-velocity heading in experienced collegiate players. Clinical Relevance: Balanced neck strength may reduce head acceleration cumulative subclinical injury. Since neck strength is a measureable and amenable strength training intervention, this may represent a modifiable intrinsic risk factor for injury. PMID:24459547

Electrostatic wire stabilizing a charged particle beam

DOEpatents

Prono, D.S.; Caporaso, G.J.; Briggs, R.J.

1983-03-21

In combination with a charged particle beam generator and accelerator, apparatus and method are provided for stabilizing a beam of electrically charged particles. A guiding means, disposed within the particle beam, has an electric charge induced upon it by the charged particle beam. Because the sign of the electric charge on the guiding means and the sign of the particle beam are opposite, the particles are attracted toward and cluster around the guiding means to thereby stabilize the particle beam as it travels.

Photothermal Stability of an E-Beam Pre-Crosslinked EVA Encapsulant and Its Performance Degradation on a-Si Submodules: Preprint

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pern, F. J.; Watson, G. L.; Glick, S. H.

2001-10-01

Presented at the 2001 NCPV Program Review Meeting: Study of photothermal stability of special EVA encapsulant by accelerated exposure testing and analysis of causes of performance degradation on a-Si modules.

Payload isolation and stabilization by a Suspended Experiment Mount (SEM)

NASA Technical Reports Server (NTRS)

Bailey, Wayne L.; Desanctis, Carmine E.; Nicaise, Placide D.; Schultz, David N.

1992-01-01

Many Space Shuttle and Space Station payloads can benefit from isolation from crew or attitude control system disturbances. Preliminary studies have been performed for a Suspended Experiment Mount (SEM) system that will provide isolation from accelerations and stabilize the viewing direction of a payload. The concept consists of a flexible suspension system and payload-mounted control moment gyros. The suspension system, which is rigidly locked for ascent and descent, isolates the payload from high frequency disturbances. The control moment gyros stabilize the payload orientation. The SEM will be useful for payloads that require a lower-g environment than a manned vehicle can provide, such as materials processing, and for payloads that require stabilization of pointing direction, but not large angle slewing, such as nadir-viewing earth observation or solar viewing payloads.

Lattice design of the integrable optics test accelerator and optical stochastic cooling experiment at Fermilab

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kafka, Gene

2015-05-01

The Integrable Optics Test Accelerator (IOTA) storage ring at Fermilab will serve as the backbone for a broad spectrum of Advanced Accelerator R&D (AARD) experiments, and as such, must be designed with signi cant exibility in mind, but without compromising cost e ciency. The nonlinear experiments at IOTA will include: achievement of a large nonlinear tune shift/spread without degradation of dynamic aperture; suppression of strong lattice resonances; study of stability of nonlinear systems to perturbations; and studies of di erent variants of nonlinear magnet design. The ring optics control has challenging requirements that reach or exceed the present state ofmore » the art. The development of a complete self-consistent design of the IOTA ring optics, meeting the demands of all planned AARD experiments, is presented. Of particular interest are the precise control for nonlinear integrable optics experiments and the transverse-to-longitudinal coupling and phase stability for the Optical Stochastic Cooling Experiment (OSC). Since the beam time-of- ight must be tightly controlled in the OSC section, studies of second order corrections in this section are presented.« less

Stability studies of amphetamine and ephedrine derivatives in urine.

PubMed

Jiménez, C; de la Torre, R; Ventura, M; Segura, J; Ventura, R

2006-10-20

Knowledge of the stability of drugs in biological specimens is a critical consideration for the interpretation of analytical results. Identification of proper storage conditions has been a matter of concern for most toxicology laboratories (both clinical and forensic), and the stability of drugs of abuse has been extensively studied. This concern should be extended to other areas of analytical chemistry like antidoping control. In this work, the stability of ephedrine derivatives (ephedrine, norephedrine, methylephedrine, pseudoephedrine, and norpseudoephedrine), and amphetamine derivatives (amphetamine, methamphetamine, 3,4-methylenedioxyamphetamine (MDA), and 3,4-methylenedioxymethamphetamine (MDMA)) in urine has been studied. Spiked urine samples were prepared for stability testing. Urine samples were quantified by GC/NPD or GC/MS. The homogeneity of each batch of sample was verified before starting the stability study. The stability of analytes was evaluated in sterilized and non-sterilized urine samples at different storage conditions. For long-term stability testing, analyte concentration in urine stored at 4 degrees C and -20 degrees C was determined at different time intervals for 24 months for sterile urine samples, and for 6 months for non-sterile samples. For short-term stability testing, analyte concentration was evaluated in liquid urine stored at 37 degrees C for 7 days. The effect of repeated freezing (at -20 degrees C) and thawing (at room temperature) was also studied in sterile urine for up to three cycles. No significant loss of the analytes under study was observed at any of the investigated conditions. These results show the feasibility of preparing reference materials containing ephedrine and amphetamine derivatives to be used for quality control purposes.

Compliance aids and medicine stability: new evidence of quality assurance.

PubMed

Glass, Beverley Dawn; Haywood, Alison; Llewelyn, Victoria; Mangan, Martina

2009-01-01

Although increasing use of compliance aids is resulting in improved clinical outcomes for patients, the stability of some drugs being repackaged into these aids is being questioned. This is due to the fact that despite their widespread use, there is limited availability of relevant stability data. This review presents clinical evidence for repackaging into Dose Administration Aids (DAAs), the Australian Pharmaceutical Advisory Committee and other guidelines on general stability issues related to repackaging and a summary of evidence for stability studies conducted in the practice. For frusemide and prochlorperazine chosen as candidates for study because of their light sensitivity, while discoloration on light exposure rendered them unacceptable for patient use, precautions in repackaging and patient counselling can easily overcome this problem. In the case of sodium valproate however, hygroscopicity results in these tablets being unusable after exposure to accelerated storage conditions. In the absence of specific data on the stability of drug products repackaged into compliance aids, the guidelines, practical recommendations for repackaging and the management of compliance aids put forward in this article provide the pharmacist with the tools to make an informed decision on this process.

Studies of dished accelerator grids for 30-cm ion thrusters

NASA Technical Reports Server (NTRS)

Rawlin, V. K.

1973-01-01

Eighteen geometrically different sets of dished accelerator grids were tested on five 30-cm thrusters. The geometric variation of the grids included the grid-to-grid spacing, the screen and accelerator hole diameters and thicknesses, the screen and accelerator open area fractions, ratio of dish depth to dish diameter, compensation, and aperture shape. In general, the data taken over a range of beam currents for each grid set included the minimum total accelerating voltage required to extract a given beam current and the minimum accelerator grid voltage required to prevent electron backstreaming.

Acceleration modules in linear induction accelerators

NASA Astrophysics Data System (ADS)

Wang, Shao-Heng; Deng, Jian-Jun

2014-05-01

The Linear Induction Accelerator (LIA) is a unique type of accelerator that is capable of accelerating kilo-Ampere charged particle current to tens of MeV energy. The present development of LIA in MHz bursting mode and the successful application into a synchrotron have broadened LIA's usage scope. Although the transformer model is widely used to explain the acceleration mechanism of LIAs, it is not appropriate to consider the induction electric field as the field which accelerates charged particles for many modern LIAs. We have examined the transition of the magnetic cores' functions during the LIA acceleration modules' evolution, distinguished transformer type and transmission line type LIA acceleration modules, and re-considered several related issues based on transmission line type LIA acceleration module. This clarified understanding should help in the further development and design of LIA acceleration modules.

Investigation of the aerothermodynamics of hypervelocity reacting flows in the ram accelerator

NASA Technical Reports Server (NTRS)

Hertzberg, A.; Bruckner, A. P.; Mattick, A. T.; Knowlen, C.

1992-01-01

New diagnostic techniques for measuring the high pressure flow fields associated with high velocity ram accelerator propulsive modes was experimentally investigated. Individual propulsive modes are distinguished by their operating Mach number range and the manner in which the combustion process is initiated and stabilized. Operation of the thermally choked ram accelerator mode begins by injecting the projectile into the accelerator tube at a prescribed entrance velocity by means of a conventional light gas gun. A specially designed obturator, which is used to seal the bore of the gun, plays a key role in the ignition of the propellant gases in the subsonic combustion mode of the ram accelerator. Once ignited, the combustion process travels with the projectile and releases enough heat to thermally choke the flow within several tube diameters behind it, thereby stabilizing a high pressure zone on the rear of the projectile. When the accelerating projectile approaches the Chapman-Jouguet detonation speed of the propellant mixture, the combustion region is observed to move up onto the afterbody of the projectile as the pressure field evolves to a distinctively different form that implies the presence of supersonic combustion processes. Eventually, a high enough Mach number is reached that the ram effect is sufficient to cause the combustion process to occur entirely on the body. Propulsive cycles utilizing on-body heat release can be established either by continuously accelerating the projectile in a single propellant mixture from low initial in-tube Mach numbers (M less than 4) or by injecting the projectile at a speed above the propellant's Chapman-Jouguet detonation speed. The results of experimental and theoretical explorations of ram accelerator gas dynamic phenomena and the effectiveness of the new diagnostic techniques are presented in this report.

Comparative study of resist stabilization techniques for metal etch processing

NASA Astrophysics Data System (ADS)

Becker, Gerry; Ross, Matthew F.; Wong, Selmer S.; Minter, Jason P.; Marlowe, Trey; Livesay, William R.

1999-06-01

This study investigates resist stabilization techniques as they are applied to a metal etch application. The techniques that are compared are conventional deep-UV/thermal stabilization, or UV bake, and electron beam stabilization. The electron beam tool use din this study, an ElectronCure system from AlliedSignal Inc., ELectron Vision Group, utilizes a flood electron source and a non-thermal process. These stabilization techniques are compared with respect to a metal etch process. In this study, two types of resist are considered for stabilization and etch: a g/i-line resist, Shipley SPR-3012, and an advanced i-line, Shipley SPR 955- Cm. For each of these resist the effects of stabilization on resist features are evaluated by post-stabilization SEM analysis. Etch selectivity in all cases is evaluated by using a timed metal etch, and measuring resists remaining relative to total metal thickness etched. Etch selectivity is presented as a function of stabilization condition. Analyses of the effects of the type of stabilization on this method of selectivity measurement are also presented. SEM analysis was also performed on the features after a compete etch process, and is detailed as a function of stabilization condition. Post-etch cleaning is also an important factor impacted by pre-etch resist stabilization. Results of post- etch cleaning are presented for both stabilization methods. SEM inspection is also detailed for the metal features after resist removal processing.

Effect of water content on stability of landslides triggered by earthquakes

NASA Astrophysics Data System (ADS)

Beyabanaki, S.; Bagtzoglou, A. C.; Anagnostou, E. N.

2013-12-01

Earthquake- triggered landslides are one of the most important natural hazards that often result in serious structural damage and loss of life. They are widely studied by several researchers. However, less attention has been focused on soil water content. Although the effect of water content has been widely studied for rainfall- triggered landslides [1], much less attention has been given to it for stability analysis of earthquake- triggered landslides. We developed a combined hydrology and stability model to investigate effect of soil water content on earthquake-triggered landslides. For this purpose, Bishop's method is used to do the slope stability analysis and Richard's equation is employed to model infiltration. Bishop's method is one the most widely methods used for analyzing stability of slopes [2]. Earthquake acceleration coefficient (EAC) is also considered in the model to analyze the effect of earthquake on slope stability. Also, this model is able to automatically determine geometry of the potential landslide. In this study, slopes with different initial water contents are simulated. First, the simulation is performed in the case of earthquake only with different EACs and water contents. As shown in Fig. 1, initial water content has a significant effect on factor of safety (FS). Greater initial water contents lead to less FS. This impact is more significant when EAC is small. Also, when initial water content is high, landslides can happen even with small earthquake accelerations. Moreover, in this study, effect of water content on geometry of landslides is investigated. For this purpose, different cases of landslides triggered by earthquakes only and both rainfall and earthquake for different initial water contents are simulated. The results show that water content has more significant effect on geometry of landslides triggered by rainfall than those triggered by an earthquake. Finally, effect of water content on landslides triggered by earthquakes

SEM/EDX and vis spectrophotometry study of the stability of resin-bound mortars used for casting replicas and filling missing parts of historic stone fountains.

PubMed

Roig-Salom, José-Luis; Doménech-Carbó, María-Teresa; de la Cruz-Cañizares, Juana; Bolívar-Galiano, Fernando; Pelufo-Carbonell, María-José; Peraza-Zurita, Yaiza

2003-04-01

A study by SEM/EDX and spectrophotometry in the visible region attempting to assess the stability of new resin-bound mortars used for casting replicas of marble historic fountains is presented in this paper. Different accelerating tests such as thermal ageing, UV light ageing, ageing in an SO(2) pollutant chamber, freezing cycles ageing, salt crystallisation ageing, natural ageing and biological attack have been applied to a series of test specimens prepared with polyester-, epoxy- and gel-coat-bound mortars. Examination of morphology, measurement of chemical composition and chromatic coordinates before and after ageing treatments establish the higher stability and resistance properties of these resin-bound mortars by comparison to those from the natural marbles.

[Study on the stability of tetrandrine microsphere].

PubMed

Cheng, Guohu; Luo, Jiabo

2005-05-01

To study the stability of Tetrandrine Microsphere. Higher speed test and room temperature test were adopted to investigate the indexes, such as properties of appearance, amount of medicine loaded, seal rate, seepage rate, microbial stability, etc. Through the test of six months, properties of appearance, amount of medicine loaded, seal rate, seepage rate, microbial stability have not obviously change. But after testing for 6 months with higher temperature, the seal rate was reduced, and the seepage rate was increased. Tetrandrine microsphere is steady under the room temperature condition, but is unstable to hot, and ought to keep in conformity with low-temperature.

Electrostatic Steering Accelerates C3d:CR2 Association

PubMed Central

2016-01-01

Electrostatic effects are ubiquitous in protein interactions and are found to be pervasive in the complement system as well. The interaction between complement fragment C3d and complement receptor 2 (CR2) has evolved to become a link between innate and adaptive immunity. Electrostatic interactions have been suggested to be the driving factor for the association of the C3d:CR2 complex. In this study, we investigate the effects of ionic strength and mutagenesis on the association of C3d:CR2 through Brownian dynamics simulations. We demonstrate that the formation of the C3d:CR2 complex is ionic strength-dependent, suggesting the presence of long-range electrostatic steering that accelerates the complex formation. Electrostatic steering occurs through the interaction of an acidic surface patch in C3d and the positively charged CR2 and is supported by the effects of mutations within the acidic patch of C3d that slow or diminish association. Our data are in agreement with previous experimental mutagenesis and binding studies and computational studies. Although the C3d acidic patch may be locally destabilizing because of unfavorable Coulombic interactions of like charges, it contributes to the acceleration of association. Therefore, acceleration of function through electrostatic steering takes precedence to stability. The site of interaction between C3d and CR2 has been the target for delivery of CR2-bound nanoparticle, antibody, and small molecule biomarkers, as well as potential therapeutics. A detailed knowledge of the physicochemical basis of C3d:CR2 association may be necessary to accelerate biomarker and drug discovery efforts. PMID:27092816

Electrostatic Steering Accelerates C3d:CR2 Association.

PubMed

Mohan, Rohith R; Huber, Gary A; Morikis, Dimitrios

2016-08-25

Electrostatic effects are ubiquitous in protein interactions and are found to be pervasive in the complement system as well. The interaction between complement fragment C3d and complement receptor 2 (CR2) has evolved to become a link between innate and adaptive immunity. Electrostatic interactions have been suggested to be the driving factor for the association of the C3d:CR2 complex. In this study, we investigate the effects of ionic strength and mutagenesis on the association of C3d:CR2 through Brownian dynamics simulations. We demonstrate that the formation of the C3d:CR2 complex is ionic strength-dependent, suggesting the presence of long-range electrostatic steering that accelerates the complex formation. Electrostatic steering occurs through the interaction of an acidic surface patch in C3d and the positively charged CR2 and is supported by the effects of mutations within the acidic patch of C3d that slow or diminish association. Our data are in agreement with previous experimental mutagenesis and binding studies and computational studies. Although the C3d acidic patch may be locally destabilizing because of unfavorable Coulombic interactions of like charges, it contributes to the acceleration of association. Therefore, acceleration of function through electrostatic steering takes precedence to stability. The site of interaction between C3d and CR2 has been the target for delivery of CR2-bound nanoparticle, antibody, and small molecule biomarkers, as well as potential therapeutics. A detailed knowledge of the physicochemical basis of C3d:CR2 association may be necessary to accelerate biomarker and drug discovery efforts.

Acceleration feedback improves balancing against reflex delay

PubMed Central

Insperger, Tamás; Milton, John; Stépán, Gábor

2013-01-01

A model for human postural balance is considered in which the time-delayed feedback depends on position, velocity and acceleration (proportional–derivative–acceleration (PDA) feedback). It is shown that a PDA controller is equivalent to a predictive controller, in which the prediction is based on the most recent information of the state, but the control input is not involved into the prediction. A PDA controller is superior to the corresponding proportional–derivative controller in the sense that the PDA controller can stabilize systems with approximately 40 per cent larger feedback delays. The addition of a sensory dead zone to account for the finite thresholds for detection by sensory receptors results in highly intermittent, complex oscillations that are a typical feature of human postural sway. PMID:23173196

Self-organizing dynamic stability of far-from-equilibrium biological systems

NASA Astrophysics Data System (ADS)

Ivanitskii, G. R.

2017-10-01

One indication of the stability of a living system is the variation of the system’s characteristic time scales. Underlying the stability mechanism are the structural hierarchy and self-organization of systems, factors that give rise to a positive (accelerating) feedback and a negative (braking) feedback. Information processing in the brain cortex plays a special role in highly organized living organisms.

Aqueous clay suspensions stabilized by alginate fluid gels for coal spontaneous combustion prevention and control.

PubMed

Qin, Botao; Ma, Dong; Li, Fanglei; Li, Yong

2017-11-01

We have developed aqueous clay suspensions stabilized by alginate fluid gels (AFG) for coal spontaneous combustion prevention and control. Specially, this study aimed to characterize the effect of AFG on the microstructure, static and dynamic stability, and coal fire inhibition performances of the prepared AFG-stabilized clay suspensions. Compared with aqueous clay suspensions, the AFG-stabilized clay suspensions manifest high static and dynamic stability, which can be ascribed to the formation of a robust three-dimensional gel network by AFG. The coal acceleration oxidation experimental results show that the prepared AFG-stabilized clay suspensions can improve the coal thermal stability and effectively inhibit the coal spontaneous oxidation process by increasing crossing point temperature (CPT) and reducing CO emission. The prepared low-cost and nontoxic AFG-stabilized clay suspensions, exhibiting excellent coal fire extinguishing performances, indicate great application potentials in coal spontaneous combustion prevention and control.

Recent results from the University of Washington's 38 mm ram accelerator

NASA Technical Reports Server (NTRS)

De Turenne, J. A.; Chew, G.; Bruckner, A. P.

1992-01-01

The ram accelerator is a propulsive device that accelerates projectiles using gasdynamic cycles similar to those which generate thrust in airbreathing ramjets. The projectile, analogous to the centerbody of a ramjet, travels supersonically through a stationary tube containing a gaseous fuel and oxidizer mixture. The projectile itself carries no onboard propellant. A combustion zone follows the projectile and stabilizes the shock structure. The resulting pressure distribution continuously accelerates the projectile. Several modes of ram accelerator operation have been investigated experimentally and theoretically. At velocities below the Chapman-Jouguet (C-J) detonation speed of the propellant mixture, the thermally choked propulsion mode accelerates the projectiles. At projectile velocities between approximately 90 and 110 percent of the C-J speed, a transdetonative propulsion mode occurs. At velocities beyond 110 percent of the C-J speed, projectiles experience superdetonative propulsion. This paper presents recent experimental results from these propulsion modes obtained with the University of Washington's 38-mm bore ram accelerator. Data from investigations with hydrogen diluted-gas mixtures are also introduced.

Long term stability following genioplasty: a cephalometric study.

PubMed

Kumar, B Lakshman; Raju, G Kranthi Praveen; Kumar, N Dilip; Reddy, G Vivek; Naik, B Ravindra; Achary, C Ravindranath

2015-04-01

A receding chin associated with an orthognathic mandible is a common situation and surgical changes in chin position are often required to improve the overall harmony of the face. Genioplasty is one such procedure. Stability of hard and soft tissue changes following genioplasty on a long term basis needs to be assessed. Studies on the stability of hard and soft tissue changes following genioplasty on a short term basis have revealed it as a procedure with good stability. This study is done to assess the stability of hard and soft tissue changes following genioplasty on a long term basis. Pre-surgical, postsurgical and long term post-surgical cephalograms of 15 cases treated by vertical reduction augmentation genioplasty were obtained. Paired t-test was used to compare the changes between pre-surgical, postsurgical and long term postsurgical cephalograms. Findings of this study demonstrated that genioplasty is a stable procedure. After long term follow-up period, there was a relapse of 1.5 mm at the pogonion accounting for 24% of the surgical advancement. This is attributed to the remodeling that occurs at the surgical site, but not the instability due to the surgical procedure. With the present study, it can be concluded that vertical reduction and advancement genioplasty can be considered as an adjunctive procedure that produces predictable results and the bony and soft tissue stability were generally very good.

Mechanisms of nitrogen heterocycle influence on turbine fuel stability

NASA Technical Reports Server (NTRS)

Daniel, S. R.; Worstell, J. H.

1980-01-01

Lewis bases were extracted from a Utah COED syncrude via ligand exchange. Addition of this extract to Jet A at levels as low as 5 ppm N produced deterioration of stability in both JFTOT and accelerated storage tests (7 days at 394 K with 13:1air to fuel ratio). Comparable effects on Jet A stability were obtained by addition of pyridine and quinoline, while pyrrole and indole were less detrimental at the same concentration level. The weight of deposit produced accelerated storage tests was found to be proportional to the concentration of added nitrogen compound. Over the narrow temperature range accessible with the experimental method, Arrhenius plots obtained by assuming specific rate to be proportional to the weight of material deposited in seven days exhibit greater slopes in the presence of those nitrogen compounds producing the greater deposition rates. It is shown that despite variation in appearance the elemental composition and spectral characteristics of the deposits are unaffected by addition of the nitrogen compounds. The linearity of the Arrhenius plots and of a plot of Arrhenius slope versus intercept for all the compounds suggests a constancy of mechanism over the range of temperature and heterocycles studied.

Studies of beam position monitor stability

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tenenbaum, P.

1998-05-01

The authors present the results from two studies of the time stability between the mechanical center of a beam position monitor and its electrical/electronic center. In the first study, a group of 93 BPM processors was calibrated via Test Pulse Generator once per hour in order to measure the contribution of the readout electronics to offset drifts. In the second study, a triplet of stripline BPMs in the Final Focus Test Beam, separated only by drift spaces, was read out every 6 minutes during 1 week of beam operation. In both cases offset stability was observed to be on themore » order of microns over time spans ranging from hours to days, although during the beam study much worse performance was also observed. Implications for the beam position monitor system of future linear collider systems are discussed.« less

Social-Emotional Characteristics of Gifted Accelerated and Non-Accelerated Students in the Netherlands

ERIC Educational Resources Information Center

Hoogeveen, Lianne; van Hell, Janet G.; Verhoeven, Ludo

2012-01-01

Background: In the studies of acceleration conducted so far a multidimensional perspective has largely been neglected. No attempt has been made to relate social-emotional characteristics of accelerated versus non-accelerated students in perspective of environmental factors. Aims: In this study, social-emotional characteristics of accelerated…

Assessment of Walking Stability of Elderly by Means of Nonlinear Time-Series Analysis and Simple Accelerometry

NASA Astrophysics Data System (ADS)

Ohtaki, Yasuaki; Arif, Muhammad; Suzuki, Akihiro; Fujita, Kazuki; Inooka, Hikaru; Nagatomi, Ryoichi; Tsuji, Ichiro

This study presents an assessment of walking stability in elderly people, focusing on local dynamic stability of walking. Its main objectives were to propose a technique to quantify local dynamic stability using nonlinear time-series analyses and a portable instrument, and to investigate their reliability in revealing the efficacy of an exercise training intervention for elderly people for improvement of walking stability. The method measured three-dimensional acceleration of the upper body, and computation of Lyapunov exponents, thereby directly quantifying the local stability of the dynamic system. Straight level walking of young and elderly subjects was investigated in the experimental study. We compared Lyapunov exponents of young and the elderly subjects, and of groups before and after the exercise intervention. Experimental results demonstrated that the exercise intervention improved local dynamic stability of walking. The proposed method was useful in revealing effects and efficacies of the exercise intervention for elderly people.

An extended car-following model considering the acceleration derivative in some typical traffic environments

NASA Astrophysics Data System (ADS)

Zhou, Tong; Chen, Dong; Liu, Weining

2018-03-01

Based on the full velocity difference and acceleration car-following model, an extended car-following model is proposed by considering the vehicle’s acceleration derivative. The stability condition is given by applying the control theory. Considering some typical traffic environments, the results of theoretical analysis and numerical simulation show the extended model has a more actual acceleration of string vehicles than that of the previous models in starting process, stopping process and sudden brake. Meanwhile, the traffic jams more easily occur when the coefficient of vehicle’s acceleration derivative increases, which is presented by space-time evolution. The results confirm that the vehicle’s acceleration derivative plays an important role in the traffic jamming transition and the evolution of traffic congestion.

Multipactor Physics, Acceleration, and Breakdown in Dielectric-Loaded Accelerating Structures

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fischer, Richard P.; Gold, Steven H.

2016-07-01

The objective of this 3-year program is to study the physics issues associated with rf acceleration in dielectric-loaded accelerating (DLA) structures, with a focus on the key issue of multipactor loading, which has been found to cause very significant rf power loss in DLA structures whenever the rf pulsewidth exceeds the multipactor risetime (~10 ns). The experiments are carried out in the X-band magnicon laboratory at the Naval Research Laboratory (NRL) in collaboration with Argonne National Laboratory (ANL) and Euclid Techlabs LLC, who develop the test structures with support from the DoE SBIR program. There are two main elements inmore » the research program: (1) high-power tests of DLA structures using the magnicon output (20 MW @11.4 GHz), and (2) tests of electron acceleration in DLA structures using relativistic electrons from a compact X-band accelerator. The work during this period has focused on a study of the use of an axial magnetic field to suppress multipactor in DLA structures, with several new high power tests carried out at NRL, and on preparation of the accelerator for the electron acceleration experiments.« less

Electron-Beam Dynamics for an Advanced Flash-Radiography Accelerator

DOE PAGES

Ekdahl, Carl

2015-11-17

Beam dynamics issues were assessed for a new linear induction electron accelerator being designed for multipulse flash radiography of large explosively driven hydrodynamic experiments. Special attention was paid to equilibrium beam transport, possible emittance growth, and beam stability. Especially problematic would be high-frequency beam instabilities that could blur individual radiographic source spots, low-frequency beam motion that could cause pulse-to-pulse spot displacement, and emittance growth that could enlarge the source spots. Furthermore, beam physics issues were examined through theoretical analysis and computer simulations, including particle-in-cell codes. Beam instabilities investigated included beam breakup, image displacement, diocotron, parametric envelope, ion hose, and themore » resistive wall instability. The beam corkscrew motion and emittance growth from beam mismatch were also studied. It was concluded that a beam with radiographic quality equivalent to the present accelerators at Los Alamos National Laboratory will result if the same engineering standards and construction details are upheld.« less

DC/DC Converter Stability Testing Study

NASA Technical Reports Server (NTRS)

Wang, Bright L.

2008-01-01

This report presents study results on hybrid DC/DC converter stability testing methods. An input impedance measurement method and a gain/phase margin measurement method were evaluated to be effective to determine front-end oscillation and feedback loop oscillation. In particular, certain channel power levels of converter input noises have been found to have high degree correlation with the gain/phase margins. It becomes a potential new method to evaluate stability levels of all type of DC/DC converters by utilizing the spectral analysis on converter input noises.

MABE multibeam accelerator

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hasti, D.E.; Ramirez, J.J.; Coleman, P.D.

1985-01-01

The Megamp Accelerator and Beam Experiment (MABE) was the technology development testbed for the multiple beam, linear induction accelerator approach for Hermes III, a new 20 MeV, 0.8 MA, 40 ns accelerator being developed at Sandia for gamma-ray simulation. Experimental studies of a high-current, single-beam accelerator (8 MeV, 80 kA), and a nine-beam injector (1.4 MeV, 25 kA/beam) have been completed, and experiments on a nine-beam linear induction accelerator are in progress. A two-beam linear induction accelerator is designed and will be built as a gamma-ray simulator to be used in parallel with Hermes III. The MABE pulsed power systemmore » and accelerator for the multiple beam experiments is described. Results from these experiments and the two-beam design are discussed. 11 refs., 6 figs.« less

Long Term Stability Following Genioplasty: A Cephalometric Study

PubMed Central

Kumar, B Lakshman; Raju, G Kranthi Praveen; Kumar, N Dilip; Reddy, G Vivek; Naik, B Ravindra; Achary, C Ravindranath

2015-01-01

Background: A receding chin associated with an orthognathic mandible is a common situation and surgical changes in chin position are often required to improve the overall harmony of the face. Genioplasty is one such procedure. Stability of hard and soft tissue changes following genioplasty on a long term basis needs to be assessed. Studies on the stability of hard and soft tissue changes following genioplasty on a short term basis have revealed it as a procedure with good stability. This study is done to assess the stability of hard and soft tissue changes following genioplasty on a long term basis. Materials and Methods: Pre-surgical, postsurgical and long term post-surgical cephalograms of 15 cases treated by vertical reduction augmentation genioplasty were obtained. Paired t-test was used to compare the changes between pre-surgical, postsurgical and long term postsurgical cephalograms. Results: Findings of this study demonstrated that genioplasty is a stable procedure. After long term follow-up period, there was a relapse of 1.5 mm at the pogonion accounting for 24% of the surgical advancement. This is attributed to the remodeling that occurs at the surgical site, but not the instability due to the surgical procedure. Conclusion: With the present study, it can be concluded that vertical reduction and advancement genioplasty can be considered as an adjunctive procedure that produces predictable results and the bony and soft tissue stability were generally very good. PMID:25954070

How to model the stability of terraced slopes? The case study of Tresenda (northern Italy)

NASA Astrophysics Data System (ADS)

Camera, Corrado; Apuani, Tiziana; Masetti, Marco

2015-04-01

Terraces are very common morphological features all around the Mediterranean Basin. They have been built to adapt the natural morphology of the territory to the development of anthropogenic activities, particularly agriculture. However, the increasing land abandonment during the last century is leading to soil degradation and stability issues, mainly due to lack of maintenance of these peculiar environments. The objective of this study was to develop a coupled hydrologic-stability model to identify possible triggering areas of superficial landslides during intense rainfall events. The model was tested on a slope uphill of the village of Tresenda, in Northern Italy, which experienced several superficial landslides in the last 35 years. Distributed stability analyses are usually carried out using an infinite slope approach, but in the case of terraces some basic assumptions of this method fail: the parallelism between topographical surface and potential sliding surface and the high ratio between slope length and failure surface depth are the most important examples. In addition, the interest is more on the stability of the terrace system (dry stone retaining wall and backfill soil) and not on soil alone. For these reasons, a stability analysis based on the global method of equilibrium is applied and soft coupled to a well know hydrological model (STARWARS). Sections of terrace, one cell wide, are recognized from the base of a wall to the top of the closest downstream one, and each cell (1 x 1 m2) is considered as a slice. The method of Sarma for circular and non-circular failure is applied. The very fine horizontal resolution (1 m) is crucial to take into consideration the hydrogeological and mechanical properties of dry stone walls (0.6-1.0 m wide). A sensitivity analysis was conducted for saturated water content, initial volumetric water content, the cohesion and friction angle of soil and walls and soil depth. The results of the sensitivity analysis showed that

Identifying Head-Trunk and Lower Limb Contributions to Gaze Stabilization During Locomotion

NASA Technical Reports Server (NTRS)

Mulavara, Ajitkumar P.; Bloomberg, Jacob J.

2003-01-01

The goal of the present study was to determine how the multiple, interdependent full-body sensorimotor subsystems respond to a change in gaze stabilization task constraints during locomotion. Nine subjects performed two gaze stabilization tasks while walking at 6.4 km/hr on a motorized treadmill: 1) focusing on a central point target; 2) reading numeral characters; both presented at 2m in front at the level of their eyes. While subjects performed the tasks we measured: temporal parameters of gait, full body sagittal plane segmental kinematics of the head, trunk, thigh, shank and foot, accelerations along the vertical axis at the head and the shank, and the vertical forces acting on the support surface. We tested the hypothesis that with the increased demands placed on visual acuity during the number recognition task, subjects would modify full-body segmental kinematics in order to reduce perturbations to the head in order to successfully perform the task. We found that while reading numeral characters as - compared to the central point target: 1) compensatory head pitch movement was on average 22% greater despite the fact that the trunk pitch and trunk vertical translation movement control were not significantly changed; 2) coordination patterns between head and trunk as reflected by the peak cross correlation between the head pitch and trunk pitch motion as well as the peak cross correlation between the head pitch and vertical trunk translation motion were not significantly changed; 3) knee joint total movement was on average 11% greater during the period from the heel strike event to the peak knee flexion event in stance phase of the gait cycle; 4) peak acceleration measured at the head was significantly reduced by an average of 13% in four of the six subjects. This was so even when the peak acceleration at the shank and the transmissibility of the shock wave at heel strike (measured by the peak acceleration ratio of the head/shank) remained unchanged. Taken

Effect of Filler Concentration on Thermal Stability of Vinyl Copolymer Elastomer (VCE) Composites

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yang, Dali; Hubbard, Kevin Mark; Devlin, David James

To study the thermal stability of vinyl copolymer elastomer (VCE) in its composite form, systematic TGA characterizations were conducted in both nonisothermal and isothermal modes. The effects of filler concentration on the aging behaviors of the VCE/filler composites were investigated under nitroplasticizer (NP) environment. FTIR characterization was used to probe the structural changes in the VCE polymer before and after the thermal treatments. This study suggests that the filler concentration significantly deteriorates the thermal stability of NP at a moderate temperature (< 70 °C). The degradation of NP, in turn, accelerates the aging process of the VCE polymer in itsmore » composite form.« less

Electrostatic wire for stabilizing a charged particle beam

DOEpatents

Prono, Daniel S.; Caporaso, George J.; Briggs, Richard J.

1985-01-01

In combination with a charged particle beam generator and accelerator, apparatus and method are provided for stabilizing a beam of electrically charged particles. A guiding means, disposed within the particle beam, has an electric charge induced upon it by the charged particle beam. Because the sign of the electric charge on the guiding means and the sign of the particle beam are opposite, the particles are attracted toward and cluster around the guiding means to thereby stabilize the particle beam as it travels.

Accelerator system and method of accelerating particles

NASA Technical Reports Server (NTRS)

Wirz, Richard E. (Inventor)

2010-01-01

An accelerator system and method that utilize dust as the primary mass flux for generating thrust are provided. The accelerator system can include an accelerator capable of operating in a self-neutralizing mode and having a discharge chamber and at least one ionizer capable of charging dust particles. The system can also include a dust particle feeder that is capable of introducing the dust particles into the accelerator. By applying a pulsed positive and negative charge voltage to the accelerator, the charged dust particles can be accelerated thereby generating thrust and neutralizing the accelerator system.

Study of stability of methotrexate in acidic solution spectrofluorimetric determination of methotrexate in pharmaceutical preparations through acid-catalyzed degradation reaction.

PubMed

Sabry, Suzy M; Abdel-Hady, M; Elsayed, M; Fahmy, Osama T; Maher, Hadir M

2003-07-14

Study of the degradation reaction of methotrexate (MTX) in acidic solution was carried out. Optimization of the experimental parameters of MTX acid hydrolysis was investigated. Spectrofluorimetric method for determination of MTX through measurement of its acid-degradation product, 4-amino-4-deoxy-10-methylpteroic acid (AMP), was developed. Stability of the standard solution of MTX prepared in sulfuric acid was discussed in the view of accelerated stability analysis. Two other comparative spectroflourimetric methods based on measuring the fluorescence intensities from either a condensation reaction with acetylacetone-formaldehyde (Hantzsch reaction) or a reaction with fluorescamine were also described. Beer's law validation, accuracy, precision, limits of detection, limits of quantification, and other aspects of analytical merit are presented in the text. The proposed methods were successfully applied for the analysis of MTX in pure drug and tablets dosage form. The sensitivity of the developed methods was favorable, so it was possible to be adopted for determination of MTX in plasma samples for routine use in high-dose MTX therapy.

Applying the methodology of Design of Experiments to stability studies: a Partial Least Squares approach for evaluation of drug stability.

PubMed

Jordan, Nika; Zakrajšek, Jure; Bohanec, Simona; Roškar, Robert; Grabnar, Iztok

2018-05-01

The aim of the present research is to show that the methodology of Design of Experiments can be applied to stability data evaluation, as they can be seen as multi-factor and multi-level experimental designs. Linear regression analysis is usually an approach for analyzing stability data, but multivariate statistical methods could also be used to assess drug stability during the development phase. Data from a stability study for a pharmaceutical product with hydrochlorothiazide (HCTZ) as an unstable drug substance was used as a case example in this paper. The design space of the stability study was modeled using Umetrics MODDE 10.1 software. We showed that a Partial Least Squares model could be used for a multi-dimensional presentation of all data generated in a stability study and for determination of the relationship among factors that influence drug stability. It might also be used for stability predictions and potentially for the optimization of the extent of stability testing needed to determine shelf life and storage conditions, which would be time and cost-effective for the pharmaceutical industry.

Stability-Derivative Determination from Flight Data

NASA Technical Reports Server (NTRS)

Holowicz, Chester H.; Holleman, Euclid C.

1958-01-01

A comprehensive discussion of the various factors affecting the determination of stability and control derivatives from flight data is presented based on the experience of the NASA High-Speed Flight Station. Factors relating to test techniques, determination of mass characteristics, instrumentation, and methods of analysis are discussed. For most longitudinal-stability-derivative analyses simple equations utilizing period and damping have been found to be as satisfactory as more comprehensive methods. The graphical time-vector method has been the basis of lateral-derivative analysis, although simple approximate methods can be useful If applied with caution. Control effectiveness has been generally obtained by relating the peak acceleration to the rapid control input, and consideration must be given to aerodynamic contributions if reasonable accuracy is to be realized.. Because of the many factors involved In the determination of stability derivatives, It is believed that the primary stability and control derivatives are probably accurate to within 10 to 25 percent, depending upon the specific derivative. Static-stability derivatives at low angle of attack show the greatest accuracy.

A Model of RHIC Using the Unified Accelerator Libraries

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pilat, F.; Tepikian, S.; Trahern, C. G.

1998-01-01

The Unified Accelerator Library (UAL) is an object oriented and modular software environment for accelerator physics which comprises an accelerator object model for the description of the machine (SMF, for Standard Machine Format), a collection of Physics Libraries, and a Perl inte,face that provides a homo­geneous shell for integrating and managing these components. Currently available physics libraries include TEAPOT++, a collection of C++ physics modules conceptually derived from TEAPOT, and DNZLIB, a differential algebra package for map generation. This software environment has been used to build a flat model of RHIC which retains the hierarchical lat­tice description while assigning specificmore » characteristics to individual elements, such as measured field har­monics. A first application of the model and of the simulation capabilities of UAL has been the study of RHIC stability in the presence of siberian snakes and spin rotators. The building blocks of RHIC snakes and rotators are helical dipoles, unconventional devices that can not be modeled by traditional accelerator phys­ics codes and have been implemented in UAL as Taylor maps. Section 2 describes the RHIC data stores, Section 3 the RHIC SMF format and Section 4 the RHIC spe­cific Perl interface (RHIC Shell). Section 5 explains how the RHIC SMF and UAL have been used to study the RHIC dynamic behavior and presents detuning and dynamic aperture results. If the reader is not familiar with the motivation and characteristics of UAL, we include in the Appendix an useful overview paper. An example of a complete set of Perl Scripts for RHIC simulation can also be found in the Appendix.« less

Accelerator Physics Working Group Summary

NASA Astrophysics Data System (ADS)

Li, D.; Uesugi, T.; Wildnerc, E.

2010-03-01

The Accelerator Physics Working Group addressed the worldwide R&D activities performed in support of future neutrino facilities. These studies cover R&D activities for Super Beam, Beta Beam and muon-based Neutrino Factory facilities. Beta Beam activities reported the important progress made, together with the research activity planned for the coming years. Discussion sessions were also organized jointly with other working groups in order to define common ground for the optimization of a future neutrino facility. Lessons learned from already operating neutrino facilities provide key information for the design of any future neutrino facility, and were also discussed in this meeting. Radiation damage, remote handling for equipment maintenance and exchange, and primary proton beam stability and monitoring were among the important subjects presented and discussed. Status reports for each of the facility subsystems were presented: proton drivers, targets, capture systems, and muon cooling and acceleration systems. The preferred scenario for each type of possible future facility was presented, together with the challenges and remaining issues. The baseline specification for the muon-based Neutrino Factory was reviewed and updated where required. This report will emphasize new results and ideas and discuss possible changes in the baseline scenarios of the facilities. A list of possible future steps is proposed that should be followed up at NuFact10.

Signature energetic analysis of accelerate electron beam after first acceleration station by accelerating stand of Joint Institute for Nuclear Research

NASA Astrophysics Data System (ADS)

Sledneva, A. S.; Kobets, V. V.

2017-06-01

The linear electron accelerator based on the LINAC - 800 accelerator imported from the Netherland is created at Joint Institute for Nuclear Research in the framework of the project on creation of the Testbed with an electron beam of a linear accelerator with an energy up to 250 MV. Currently two accelerator stations with a 60 MV energy of a beam are put in operation and the work is to put the beam through accelerating section of the third accelerator station. The electron beam with an energy of 23 MeV is used for testing the crystals (BaF2, CsI (native), and LYSO) in order to explore the opportunity to use them in particle detectors in experiments: Muon g-2, Mu2e, Comet, whose preparation requires a detailed study of the detectors properties such as their irradiation by the accelerator beams.

Evaluation of the thermal stability of a novel strain of live-attenuated mumps vaccine (RS-12 strain) lyophilized in different stabilizers.

PubMed

Jamil, Razieh Kamali; Taqavian, Mohammad; Sadigh, Zohreh-Azita; Shahkarami, Mohammad-Kazem; Esna-Ashari, Fatemeh; Hamkar, Rasool; Hosseini, Seyedeh-Marzieh; Hatami, Alireza

2014-04-01

The stability of live-attenuated viral vaccines is important for immunization efficacy. Here, the thermostabilities of lyophilized live-attenuated mumps vaccine formulations in two different stabilizers, a trehalose dihydrate-based stabilizer and a stabilizer containing sucrose, human serum albumin and sorbitol were investigated using accelerated stability tests at 4°C, 25°C and 37°C at time points between 4h (every 4h for the first 24h) and 1 week. Even under the harshest storage conditions of 37°C for 1 week, the 50% cell culture infective dose (CCID50) determined from titrations in Vero cells dropped by less than 10-fold using each stabilizer formulation and thus complied with the World Health Organization's requirements for the potency of live-attenuated mumps vaccines. However, as the half-life of the RS-12 strain mumps virus infectivity was lengthened substantially at elevated temperatures using the trehalose dihydrate (TD)-based stabilizer, this stabilizer is recommended for vaccine use. Copyright © 2013 Elsevier B.V. All rights reserved.

Laser Radiation Pressure Acceleration of Monoenergetic Protons in an Ultra-Thin Foil

NASA Astrophysics Data System (ADS)

Eliasson, Bengt; Liu, Chuan S.; Shao, Xi; Sagdeev, Roald Z.; Shukla, Padma K.

2009-11-01

We present theoretical and numerical studies of the acceleration of monoenergetic protons in a double layer formed by the laser irradiation of an ultra-thin film. The stability of the foil is investigated by direct Vlasov-Maxwell simulations for different sets of laser-plasma parameters. It is found that the foil is stable, due to the trapping of both electrons and ions in the thin laser-plasma interaction region, where the electrons are trapped in a potential well composed of the ponderomo-tive potential of the laser light and the electrostatic potential due to the ions, and the ions are trapped in a potential well composed of the inertial potential in an accelerated frame and the electrostatic potential due to the electrons. The result is a stable double layer, where the trapped ions are accelerated to monoenergetic energies up to 100 MeV and beyond, which makes them suitable for medical applications cancer treatment. The underlying physics of trapped and untapped ions in a double layer is also investigated theoretically and numerically.

Clay facial masks: physicochemical stability at different storage temperatures.

PubMed

Zague, Vivian; de Almeida Silva, Diego; Baby, André Rolim; Kaneko, Telma Mary; Velasco, Maria Valéria Robles

2007-01-01

Clay facial masks--formulations that contain a high percentage of solids dispersed in a liquid vehicle--have become of special interest due to specific properties presented by clays, such as particle size, cooling index, high adsorption capacity, and plasticity. Although most of the physicochemical properties of clay dispersions have been studied, specific aspects concerning the physicochemical stability of clay mask products remain unclear. This work aimed at investigating the accelerated physicochemical stability of clay mask formulations stored at different temperatures. Formulations were subjected to centrifuge testing and to thermal treatment for 15 days, during which temperature was varied from -5.0 degrees to 45.0 degrees C. The apparent viscosity and visual aspect (homogeneity) of all formulations were affected by temperature variation, whereas color, odor, and pH value remained unaltered. These results, besides the estimation of physicochemical stability under aging, can be useful in determining the best storage conditions for clay-based formulations.

Lack of a synergistic effect of arginine-glutamic acid on the physical stability of spray-dried bovine serum albumin.

PubMed

Reslan, Mouhamad; Demir, Yusuf K; Trout, Bernhardt L; Chan, Hak-Kim; Kayser, Veysel

2017-09-01

Improving the physical stability of spray-dried proteins is essential for enabling pulmonary delivery of biotherapeutics as a noninvasive alternative to injections. Recently, a novel combination of two amino acids - l-arginine (l-Arg) and l-glutamic acid (l-Glu), has been reported to have synergistic protein-stabilizing effects on various protein solutions. Using spray-dried bovine serum albumin (BSA) reconstituted in solution as a model protein, we investigated the synergistic effect of these amino acids on the physical stability of proteins. Five BSA solutions were prepared: (1) BSA with no amino acids (control); (2) with 50 mM l-Arg; (3) with 200 mM l-Arg, (4) with 50 mM l-Glu and (5) with 25:25 mM of Arg:Glu. All solutions were spray-dried and accelerated studies at high temperatures were performed. Following accelerated studies, monomer BSA loss was measured using SE-HPLC. We found that l-Arg significantly improved the physical stability of spray-dried BSA even at low concentrations, however, when combined with l-Glu, was ineffective at reducing monomer BSA loss. Our findings demonstrate the limitations in using Arg-Glu for the stabilization of spray-dried BSA. Furthermore, we found that a low concentration of l-Glu enhanced monomer BSA loss. These findings may have significant implications on the design of future biotherapeutic formulations.

Effect of Halide Composition on the Photochemical Stability of Perovskite Photovoltaic Materials.

PubMed

Misra, Ravi K; Ciammaruchi, Laura; Aharon, Sigalit; Mogilyansky, Dmitry; Etgar, Lioz; Visoly-Fisher, Iris; Katz, Eugene A

2016-09-22

The photochemical stability of encapsulated films of mixed halide perovskites with a range of MAPb(I 1-x Br x ) 3 (MA=methylammonium) compositions (solid solutions) was investigated under accelerated stressing using concentrated sunlight. The relevance of accelerated testing to standard operational conditions of solar cells was confirmed by comparison to degradation experiments under outdoor sunlight exposure. We found that MAPbBr 3 films exhibited no degradation, while MAPbI 3 and mixed halide MAPb(I 1-x Br x ) 3 films decomposed yielding crystallization of inorganic PbI 2 accompanied by degradation of the perovskite solar light absorption, with faster absorption degradation in mixed halide films. The crystal coherence length was found to correlate with the stability of the films. We postulate that the introduction of Br into the mixed halide solid solution stressed its structure and induced more structural defects and/or grain boundaries compared to pure halide perovskites, which might be responsible for the accelerated degradation. Hence, the cause for accelerated degradation may be the increased defect density rather than the chemical composition of the perovskite materials. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Design study of electron cyclotron resonance-ion plasma accelerator for heavy ion cancer therapy.

PubMed

Inoue, T; Hattori, T; Sugimoto, S; Sasai, K

2014-02-01

Electron Cyclotron Resonance-Ion Plasma Accelerator (ECR-IPAC) device, which theoretically can accelerate multiple charged ions to several hundred MeV with short acceleration length, has been proposed. The acceleration mechanism is based on the combination of two physical principles, plasma electron ion adiabatic ejection (PLEIADE) and Gyromagnetic Autoresonance (GYRAC). In this study, we have designed the proof of principle machine ECR-IPAC device and simulated the electromagnetic field distribution generating in the resonance cavity. ECR-IPAC device consisted of three parts, ECR ion source section, GYRAC section, and PLEIADE section. ECR ion source section and PLEIADE section were designed using several multi-turn solenoid coils and sextupole magnets, and GYRAC section was designed using 10 turns coil. The structure of ECR-IPAC device was the cylindrical shape, and the total length was 1024 mm and the maximum diameter was 580 mm. The magnetic field distribution, which maintains the stable acceleration of plasma, was generated on the acceleration center axis throughout three sections. In addition, the electric field for efficient acceleration of electrons was generated in the resonance cavity by supplying microwave of 2.45 GHz.

Effect of thermal aging on stability of transformer oil based temperature sensitive magnetic fluids

NASA Astrophysics Data System (ADS)

Kaur, Navjot; Chudasama, Bhupendra

2018-04-01

Synthesizing stable temperature sensitive magnetic fluids with tunable magnetic properties that can be used as coolant in transformers is of great interest, however not exploited commercially due to the lack of its stability at elevated temperatures in bulk quantities. The task is quite challenging as the performance parameters of magnetic fluids are strongly influenced by thermal aging. In this article, we report the effect of thermal aging on colloidal stability and magnetic properties of Mn1-xZnxFe2O4 magnetic fluids prepared in industrial grade transformer oil. As-synthesized magnetic fluids possess good dispersion stability and tunable magnetic properties. Effect of accelerated thermal aging on the dispersion stability and magnetic properties have been evaluated by photon correlation spectroscopy and vibration sample magnetometry, respectively. Magnetic fluids are stable under accelerated aging at elevated temperatures (from 50 °C to 125 °C), which is critical for their efficient performance in high power transformers.

Parametric study of transport beam lines for electron beams accelerated by laser-plasma interaction

NASA Astrophysics Data System (ADS)

Scisciò, M.; Lancia, L.; Migliorati, M.; Mostacci, A.; Palumbo, L.; Papaphilippou, Y.; Antici, P.

2016-03-01

In the last decade, laser-plasma acceleration of high-energy electrons has attracted strong attention in different fields. Electrons with maximum energies in the GeV range can be laser-accelerated within a few cm using multi-hundreds terawatt (TW) lasers, yielding to very high beam currents at the source (electron bunches with up to tens-hundreds of pC in a few fs). While initially the challenge was to increase the maximum achievable electron energy, today strong effort is put in the control and usability of these laser-generated beams that still lack of some features in order to be used for applications where currently conventional, radio-frequency (RF) based, electron beam lines represent the most common and efficient solution. Several improvements have been suggested for this purpose, some of them acting directly on the plasma source, some using beam shaping tools located downstream. Concerning the latter, several studies have suggested the use of conventional accelerator magnetic devices (such as quadrupoles and solenoids) as an easy implementable solution when the laser-plasma accelerated beam requires optimization. In this paper, we report on a parametric study related to the transport of electron beams accelerated by laser-plasma interaction, using conventional accelerator elements and tools. We focus on both, high energy electron beams in the GeV range, as produced on petawatt (PW) class laser systems, and on lower energy electron beams in the hundreds of MeV range, as nowadays routinely obtained on commercially available multi-hundred TW laser systems. For both scenarios, our study allows understanding what are the crucial parameters that enable laser-plasma accelerators to compete with conventional ones and allow for a beam transport. We show that suitable working points require a tradeoff-combination between low beam divergence and narrow energy spread.

Parametric study of transport beam lines for electron beams accelerated by laser-plasma interaction

DOE Office of Scientific and Technical Information (OSTI.GOV)

Scisciò, M.; Antici, P., E-mail: patrizio.antici@polytechnique.edu; INRS-EMT, Université du Québec, 1650 Lionel Boulet, Varennes, Québec J3X 1S2

2016-03-07

In the last decade, laser-plasma acceleration of high-energy electrons has attracted strong attention in different fields. Electrons with maximum energies in the GeV range can be laser-accelerated within a few cm using multi-hundreds terawatt (TW) lasers, yielding to very high beam currents at the source (electron bunches with up to tens-hundreds of pC in a few fs). While initially the challenge was to increase the maximum achievable electron energy, today strong effort is put in the control and usability of these laser-generated beams that still lack of some features in order to be used for applications where currently conventional, radio-frequencymore » (RF) based, electron beam lines represent the most common and efficient solution. Several improvements have been suggested for this purpose, some of them acting directly on the plasma source, some using beam shaping tools located downstream. Concerning the latter, several studies have suggested the use of conventional accelerator magnetic devices (such as quadrupoles and solenoids) as an easy implementable solution when the laser-plasma accelerated beam requires optimization. In this paper, we report on a parametric study related to the transport of electron beams accelerated by laser-plasma interaction, using conventional accelerator elements and tools. We focus on both, high energy electron beams in the GeV range, as produced on petawatt (PW) class laser systems, and on lower energy electron beams in the hundreds of MeV range, as nowadays routinely obtained on commercially available multi-hundred TW laser systems. For both scenarios, our study allows understanding what are the crucial parameters that enable laser-plasma accelerators to compete with conventional ones and allow for a beam transport. We show that suitable working points require a tradeoff-combination between low beam divergence and narrow energy spread.« less

Characterization of flame stabilization technologies

NASA Astrophysics Data System (ADS)

Bush, Scott Matthew

To experimentally explore and characterize a V-gutter stabilized flame, this research study developed a Combustion Wind Tunnel Test Facility capable of effectively simulating the freestream Mach #'s and temperatures achieved within the back end of a gas turbine jet engine. After validating this facility, it was then used to gain a better understanding of the flow dynamics and combustion dynamics associated with the V-gutter configuration. The motivation for studying the V-gutter stabilized flame is due to the concern in industry today with combustion instabilities that are encountered in military aircraft. To gain a better understanding of the complex flow field associated with the V-gutter stabilized flame, this research study utilized Particle Image Velocimetry to capture both non-reacting and reacting instantaneous and mean flow structures formed in the wake region of the three dimensional V-gutter bluff body. The results of this study showed significant differences between the non-reacting and reacting flow fields. The non-reacting case resulted in asymmetric shedding of large scale vortices from the V-gutter edges while the reacting case resulted in a combination of both symmetric and asymmetric shedding of smaller scale vortical structures. A comparison of the mean velocity components shows that the reacting case results in a larger region of reversed flow, experiences an acceleration of the freestream flow due to combustion, and results in a slower dissipation of the wake region. Simultaneous dynamic pressure and CH* chemiluminescence measurements were also recorded to determine the coupling between the flow dynamics and combustion dynamics. The results of this study showed that only low frequency combustion instabilities were encountered at various conditions within the envelope of stable operation because of the interaction between longitudinal acoustic waves and unsteady heat release. When approaching rich blow out, rms pressure amplitudes were as high as

Plasma Wakefield Acceleration and FACET - Facilities for Accelerator Science and Experimental Test Beams at SLAC

ScienceCinema

Seryi, Andrei

2017-12-22

Plasma wakefield acceleration is one of the most promising approaches to advancing accelerator technology. This approach offers a potential 1,000-fold or more increase in acceleration over a given distance, compared to existing accelerators.  FACET, enabled by the Recovery Act funds, will study plasma acceleration, using short, intense pulses of electrons and positrons. In this lecture, the physics of plasma acceleration and features of FACET will be presented.  

Stability Studies of a Freeze-Dried Recombinant Human Epidermal Growth Factor Formulation for Wound Healing.

PubMed

Santana, Héctor; García, Gerardo; Vega, Maribel; Beldarraín, Alejandro; Páez, Rolando

2015-01-01

We report on the stability assessment of a recombinant human epidermal growth factor (rhEGF) freeze-dried formulation for wound healing by intra-lesional injections. The suitability of packaging material for the light protection of finished dried powder was evaluated after stressed exposure conditions. Degradation kinetics of powder for injection was investigated at concentrations of 25-250 μg/vial and temperatures of 45, 60, and 70 °C. The long-term stability was evaluated after storage at 25 ± 2 °C/60 ± 5% relative humidity (6 months) and 2-8 °C (24 months) in the dark and analyzed at several time points. The stability after reconstitution with various diluents was also assessed after 24 h storage at 2-8 °C. The rhEGF samples were analyzed for structural integrity by reversed-phase high-performance liquid chromatography (RP-HPLC), size-exclusion HPLC, and sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE). Biological activity was investigated by measuring the cell proliferation in a murine fibroblast cell line. Results show that freeze-dried rhEGF in primary packaging only was photosensitive, as degradation by RP-HPLC that was completely suppressed by the secondary carton package was revealed. An increase in freeze-dried rhEGF stability was observed with the increase in protein concentration from 25 to 250 μg/vial. The long-term stability study showed no significant rhEGF degradation or physical change within the freeze-dried formulations containing 25 or 250 μg/vial of rhEGF. No physical, chemical or biological changes were observed for rhEGF after reconstitution in water for injection or 0.9% sodium chloride during the storage conditions studied. The stability of a recombinant human epidermal growth factor (rhEGF) freeze-dried formulation for wound healing by intra-lesional injections was assessed. The suitability of packaging material for the light protection of finished dried powder was evaluated after stressed exposure conditions

On the Stability of a Can of Soda

ERIC Educational Resources Information Center

Benesh, G. A.; Olafsen, J. S.

2014-01-01

Stability is often an important consideration in both static and dynamic systems. While introductory students soon grasp the balance of forces required for constant velocity motion, it generally takes longer for them to reliably identify the various torques involved in producing rotational equilibrium. Accelerating systems have the additional…

Stability studies of oxytetracycline in methanol solution

NASA Astrophysics Data System (ADS)

Wang, Wei; Wu, Nan; Yang, Jinghui; Zeng, Ming; Xu, Chenshan; Li, Lun; Zhang, Meng; Li, Liting

2018-02-01

As one kind of typical tetracycline antibiotics, antibiotic residues of oxytetracycline have been frequently detected in many environmental media. In this study, the stability of oxytetracycline in methanol solution was investigated by high-performance liquid chromatography combined with UV-vis (HPLC-UV). The results show that the stability of oxytetracycline in methanol solution is highly related to its initial concentration and the preserved temperature. Under low temperature condition, the solution was more stable than under room temperature preservation. Under the same temperature preservation condition, high concentrations of stock solutions are more stable than low concentrations. The study provides a foundation for preserving the oxytetracycline-methanol solution.

Sensitivity of stability indices to dealerting

DOE Office of Scientific and Technical Information (OSTI.GOV)

Canavan, G.H.

1998-03-01

It is reported that more than 100 former or current heads of state and civilian leaders from around the world, including ex-presidents Jimmy Carter and Mikhail Gorbachev, have signed a statement that calls for removing nuclear weapons from alert status and other measures aimed at the eventual elimination of atomic arsenals--reflecting mounting support for the cause of nuclear bolition. This note uses stability analysis derived from current US and Russian analyses to study the impact of such dealerting on stability, indicating that it could be negative. Dealerting forces removes them from first and second strikes for as long as theymore » are dealerted. If they are dealerted for periods long compared to those involved in the evaluation of first strike stability, dealerting has the same effect as permanent arms reductions, it subtracts them from first and second strikes. Thus, it is conceptually a way of implementing such reductions on an accelerated scale. Dealerting strategic forces has been posited as a stabilizing step towards their abolition. Previous reports have shown that planned START reductions will reduce stability indices by about a factor of two. Dealerting would hasten those reductions. They would also raise the possibility that one side could realert faster than the other. If so, the remobilized forces could be used to damage limit, which would reduce his first strike cost and stability index. The impact of complete demobilization of SSBNs would be an order of magnitude reduction in the overall stability index, to a level set by alert ICBMs. Generally, it would be preferable to maintain any existing strategic forces at the highest level of alert to minimize this effect and to concentrate instead on decreasing their total number.« less

Study of the heat stability of sunflower oil enriched in natural antioxidants by different analytical techniques and front-face fluorescence spectroscopy combined with Independent Components Analysis.

PubMed

Ammari, Faten; Jouan-Rimbaud-Bouveresse, Delphine; Boughanmi, Néziha; Rutledge, Douglas N

2012-09-15

The aim of this study was to find objective analytical methods to study the degradation of edible oils during heating and thus to suggest solutions to improve their stability. The efficiency of Nigella seed extract as natural antioxidant was compared with butylated hydroxytoluene (BHT) during accelerated oxidation of edible vegetable oils at 120 and 140 °C. The modifications during heating were monitored by 3D-front-face fluorescence spectroscopy along with Independent Components Analysis (ICA), (1)H NMR spectroscopy and classical physico-chemical methods such as anisidine value and viscosity. The results of the study clearly indicate that the natural seed extract at a level of 800 ppm exhibited antioxidant effects similar to those of the synthetic antioxidant BHT at a level of 200 ppm and thus contributes to an increase in the oxidative stability of the oil. Copyright © 2012 Elsevier B.V. All rights reserved.

FAST/Polar Conjunction Study of Field-Aligned Auroral Acceleration and Corresponding Magnetotail Drivers

NASA Technical Reports Server (NTRS)

Schriver, D.; Ashour-Abdalla, M.; Strangeway, R. J.; Richard, R. L.; Klezting, C.; Dotan, Y.; Wygant, J.

2003-01-01

The discrete aurora results when energized electrons bombard the Earth's atmosphere at high latitudes. This paper examines the physical processes that can cause field-aligned acceleration of plasma particles in the auroral region. A data and theoretical study has been carried out to examine the acceleration mechanisms that operate in the auroral zone and to identi@ the magnetospheric drivers of these acceleration mechanisms. The observations used in the study were collected by the Fast Auroral Snapshot (FAST) and Polar satellites when the two satellites were in approximate magnetic conjunction in the auroral region. During these events FAST was in the middle of the auroral zone and Polar was above the auroral zone in the near-Earth plasma sheet. Polar data were used to determine the conditions in the magnetotail at the time field-aligned acceleration was measured by FAST in the auroral zone. For each of the magnetotail drivers identified in the data study, the physics of field-aligned acceleration in the auroral region was examined using existing theoretical efforts and/or a long-system particle in cell simulation to model the magnetically connected region between the two satellites. Results from the study indicate that there are three main drivers of auroral acceleration: (1) field-aligned currents that lead to quasistatic parallel potential drops (parallel electric fields), (2) earthward flow of high-energy plasma beams from the magnetotail into the auroral zone that lead to quasistatic parallel potential drops, and (3) large-amplitude Alfven waves that propagate into the auroral region from the magnetotail. The events examined thus far confm the previously established invariant latitudinal dependence of the drivers and show a strong dependence on magnetic activity. Alfven waves tend to occur primarily at the poleward edge of the auroral region during more magnetically active times and are correlated with intense electron precipitation. At lower latitudes away

Coupler Studies for PBG Fiber Accelerators

DOE Office of Scientific and Technical Information (OSTI.GOV)

England, J.; Ng, C.; Noble, R.

Photonic band gap (PBG) fiber with hollow core defects are being designed and fabricated for use as laser driven accelerators because they can provide gradients of several GeV/m for picosecond pulse lengths. We expect to produce fiber down to {lambda} = 1.5-2.0 {micro}m wavelengths but still lack a viable means for efficient coupling of laser power into such structures due to the very different character of the TM-like modes from those used in the telecom field and the fact that the defect must function as both a longitudinal waveguide for the accelerating field and a transport channel for the particles.more » We discuss the status of our work in pursuing both end and side coupling. For both options, the symmetry of these crystals leads to significant differences with the telecom field. Side coupling provides more options and appears to be preferred. Our goals are to test gradients, mode content and coupling efficiencies on the NLCTA at SLAC. While there are many potential types of fiber based on very different fabrication methods and materials we will concentrate on 2D axisymmetric glass with hexagonal symmetry but will discuss several different geometries including 2D and 3D planar structures. Since all of these can be fabricated using modern techniques with a variety of dielectric materials they are expected to have desirable optical and radiation hardness properties. Thus, we expect a new generation of very high gradient accelerators that extends the Livingston-Panofsky chart of exponential growth in energy vs. time at greatly reduced costs. For illustration, Fig.1 shows a simulation of our first engineered fiber with an accelerating mode expected near 7.3 {micro}m that is now ready to test on the NLCTA. In this example, one sees the uniform longitudinal accelerating field in the central defect as first shown by Lin3 together with a hexagonal array of surrounding hot spots. Contrary to what one expects from the telecom field, Ng et al. have shown4 that the

The World of Wonder Accelerated Learning Community: A Case Study.

ERIC Educational Resources Information Center

Biddle, Julie K.

This report presents a case study of the World of Wonders Accelerated Learning Community School (WOW). A community school in Ohio is a new kind of public school-an independent public school that is nonsectarian and nondiscriminatory. The report presents three contexts for the study--historical, local and methodological--and highlights some of the…

The Influence of Knee Flexion Angle for Graft Fixation on Rotational Knee Stability During Anterior Cruciate Ligament Reconstruction: A Biomechanical Study.

PubMed

Debandi, Aníbal; Maeyama, Akira; Hoshino, Yuichi; Asai, Shigehiro; Goto, Bunsei; Smolinski, Patrick; Fu, Freddie H

2016-11-01

To evaluate the effect of knee flexion angle for hamstring graft fixation, full extension (FE), or 30°, on acceleration of the knee motion during pivot-shift testing after either anatomic or nonanatomic anterior cruciate ligament (ACL) reconstruction using triaxial accelerometry. Two types of ACL reconstructions (anatomic and nonanatomic) using 2 different angles of knee flexion during graft fixation (FE and 30°) were performed on 12 fresh-frozen human knees making 4 groups: anatomic-FE, anatomic-30°, nonanatomic-FE, and nonanatomic-30°. Manual pivot-shift testing was performed at ACL-intact, ACL-deficient, and ACL-reconstructed conditions. Three-dimensional acceleration of knee motion was recorded using a triaxial accelerometer. The anatomic-30° group showed the smallest overall magnitude of acceleration among the ACL-reconstructed groups (P = .0039). There were no significant differences among the anatomic-FE group, the nonanatomic-FE group, and the nonantomic-30° group (anatomic-FE vs nonanatomic-FE, P = .1093; anatomic-FE vs nonanatomic-30°, P = .8728; and nonanatomic-FE vs nonanatomic-30°, P = .1093). After ACL transection, acceleration was reduced by ACL reconstruction with the exception of the nonanatomic-FE group that did not show a significant difference when compared with the ACL-deficient (P = .4537). The anatomic ACL reconstruction with the graft fixed at 30° of knee flexion better restored rotational knee stability compared with FE. An ACL graft fixed with the knee at FE in anatomic position did not show a significant difference compared with the nonanatomic ACL reconstructions. Knee flexion angle at the time of graft fixation for ACL reconstruction can be considered to maximize the rotational knee stability. Copyright © 2016 Arthroscopy Association of North America. Published by Elsevier Inc. All rights reserved.

Modified Betatron Accelerator Studies.

DTIC Science & Technology

1983-12-01

extraction ports. 29 14 Combined negative mass and beam breakup instability growth rates (solid curves) for t - 13 and Be - 2 kG. Growth of the negative...a stable beam equilibrium 0 for the duration of the acceleration period, typically thousands of revolu- tions; and (c) extraction of the beam, which...bom extraction , it was felt that it would be premature to start work eI I’l 1r a S - - Fip’S .1IU~V~~’ f mdifedbetO coflCPt’ The ajo radius of U tS W

Endotoxin Studies And Biosolids Stabilization Research

EPA Science Inventory

This presentation has three parts; a review of bench-scale endotoxin research, a review of observations from a field scale endotoxin release study, and discussion of biosolids stabilization and characterization by PLFA/FAME microbial community analysis. Endotoxins are part of th...

Developments in Understanding Stability as Applied to Magnetic Levitated Launch Assist

NASA Technical Reports Server (NTRS)

Gering, James A.

2002-01-01

Magnetic levitation is a promising technology, with the potential of constituting the first stage of a third generation space transportation system. Today, the Space Shuttle burns on the order of one million pounds of solid rocket propellant to bring the orbiter and external tank to nearly Mach 1 (1,000 kph). Imagine the reductions in launch vehicle weight, complexity and risk if an aerospace vehicle could be accelerated to the same speed utilizing about $1,000 of off-board electrical energy stored in flywheels. After over two decades of development, maglev trains travel on full-scale demonstration tracks in Germany and Japan reaching speeds approaching 500 kph. Encouraging as this may appear, the energy and power required to accelerate a 1 million pound launch vehicle to 1,000 kph would radically redefine the state-of-the-art in electrical energy storage and delivery. Reaching such a goal will require levitation with sufficient stability to withstand an operating environment fundamentally different from that of a high-speed train. Recently NASA let contracts for the construction of three maglev demonstration tracks. This construction and several associated trade studies represent a first-order investigation into the feasibility of maglev launch assist. This report provides a review of these efforts, other government sponsored maglev projects and additional technical literature pertinent to maglev stability. This review brings to light details and dimensions of the maglev stability problem which are not found in previous NASA-sponsored trade studies and which must be addressed in order to realize magnetic levitation as a launch assist technology.

A compact electron cyclotron resonance proton source for the Paul Scherrer Institute's proton accelerator facility

DOE Office of Scientific and Technical Information (OSTI.GOV)

Baumgarten, C.; Barchetti, A.; Einenkel, H.

2011-05-15

A compact electron cyclotron resonance proton source has been developed and installed recently at thePaul Scherrer Institute's high intensity proton accelerator. Operation at the ion source test stand and the accelerator demonstrates a high reliability and stability of the new source. When operated at a 10 - 12 mA net proton current the lifetime of the source exceeds 2000 h. The essential development steps towards the observed performance are described.

[Evaluation of the influence of sterilization method on the stability of carboxymethyl cellulose wound dressing].

PubMed

Muselík, Jan; Wojnarová, Lenka; Masteiková, Ruta; Sopuch, Tomáš

2013-04-01

Carboxymethyl cellulose, especially its sodium salt, is a versatile pharmaceutical excipient. From a therapeutic point of view, sodium salt of carboxymethyl cellulose is used in the production of modern wound dressings to allow moist wound healing. Wound dressings must be sterile and stable throughout their shelf life and have to be able to withstand different temperature conditions. At the present time, a number of sterilization methods are available. In the case of polymeric materials, the selected sterilization process must not induce any changes in the polymer structure, such as polymer chains cleavage, changes in cross-linking, etc. This paper evaluates the influence of different sterilization methods (γ-radiation, β-radiation, ethylene oxide) on the stability of carboxymethyl cellulose and the results of long-term and accelerated stability testing. Evaluation of samples was performed using size-exclusion chromatography. The obtained results showed that ethylene oxide sterilization was the least aggressive variant of the sterilization methods tested. When the γ-radiation sterilization was used, the changes in the size of the carboxymethyl cellulose molecule occurred. In the course of accelerated and long term stability studies, no further degradation changes were observed, and thus sterilized samples are suitable for long term storage.

Temporal acceleration of spatially distributed kinetic Monte Carlo simulations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chatterjee, Abhijit; Vlachos, Dionisios G.

The computational intensity of kinetic Monte Carlo (KMC) simulation is a major impediment in simulating large length and time scales. In recent work, an approximate method for KMC simulation of spatially uniform systems, termed the binomial {tau}-leap method, was introduced [A. Chatterjee, D.G. Vlachos, M.A. Katsoulakis, Binomial distribution based {tau}-leap accelerated stochastic simulation, J. Chem. Phys. 122 (2005) 024112], where molecular bundles instead of individual processes are executed over coarse-grained time increments. This temporal coarse-graining can lead to significant computational savings but its generalization to spatially lattice KMC simulation has not been realized yet. Here we extend the binomial {tau}-leapmore » method to lattice KMC simulations by combining it with spatially adaptive coarse-graining. Absolute stability and computational speed-up analyses for spatial systems along with simulations provide insights into the conditions where accuracy and substantial acceleration of the new spatio-temporal coarse-graining method are ensured. Model systems demonstrate that the r-time increment criterion of Chatterjee et al. obeys the absolute stability limit for values of r up to near 1.« less

Acceleration of GPU-based Krylov solvers via data transfer reduction

DOE PAGES

Anzt, Hartwig; Tomov, Stanimire; Luszczek, Piotr; ...

2015-04-08

Krylov subspace iterative solvers are often the method of choice when solving large sparse linear systems. At the same time, hardware accelerators such as graphics processing units continue to offer significant floating point performance gains for matrix and vector computations through easy-to-use libraries of computational kernels. However, as these libraries are usually composed of a well optimized but limited set of linear algebra operations, applications that use them often fail to reduce certain data communications, and hence fail to leverage the full potential of the accelerator. In this study, we target the acceleration of Krylov subspace iterative methods for graphicsmore » processing units, and in particular the Biconjugate Gradient Stabilized solver that significant improvement can be achieved by reformulating the method to reduce data-communications through application-specific kernels instead of using the generic BLAS kernels, e.g. as provided by NVIDIA’s cuBLAS library, and by designing a graphics processing unit specific sparse matrix-vector product kernel that is able to more efficiently use the graphics processing unit’s computing power. Furthermore, we derive a model estimating the performance improvement, and use experimental data to validate the expected runtime savings. Finally, considering that the derived implementation achieves significantly higher performance, we assert that similar optimizations addressing algorithm structure, as well as sparse matrix-vector, are crucial for the subsequent development of high-performance graphics processing units accelerated Krylov subspace iterative methods.« less

Finite element simulation of structural performance on flexible pavements with stabilized base/treated subbase materials under accelerated loading.

DOT National Transportation Integrated Search

2011-12-01

Accelerated pavement testing (APT) has been increasingly used by state highway agencies in recent years for evaluating pavement structures and/or materials. However, running an APT experiment is expensive. It requires costly accelerated loading devic...

Effects of seasonings on the stability of ascorbic acid in a cooking model system.

PubMed

Kishida, Etsu; Maeda, Tomoko; Nishihama, Akiko; Kojo, Shosuke; Masuzawa, Yasuo

2004-12-01

The thermolability of ascorbic acid (AA) in aqueous solution at 100 degrees C was assessed in the presence of various seasonings commonly used in Japanese-style cooking. A model system approximated Japanese cooking with regard to the concentrations of AA and seasonings and the heating time. The decrease of AA in the reaction system of this experiment was a first-order reaction with respect to the concentration of AA loss. Although kinetic constants for AA loss decreased with increasing concentrations of AA (25-400 microg/mL), the absolute amounts degraded were almost the same for all AA concentrations, suggesting that dissolved oxygen is one of main factors affecting the stability of AA solutions during heating at 100 degrees C. When each seasoning was added to AA solution, salt stabilized AA and Japanese alcohol-containing admixtures, such as sake and sweet sake (mirin), did not have a significant effect on the stability. Conversely, soy sauce, miso (fermented soybean paste) and broth powder from skipjack accelerated the decrease of AA in a concentration-dependent manner. The kinetic study suggested that oxygen was rapidly consumed and AA loss accelerated by addition of soy sauce or miso to AA solution. Consequently it is likely that a reaction mechanism shifts from aerobic to anaerobic and the forward reactions proceed. Of the constituents of Japanese seasonings, not only iron but also amino acids are involved in the acceleration of AA degradation. The presence of amino acids should be taken into account when considering the levels of AA in soups.

Beyond injection: Trojan horse underdense photocathode plasma wakefield acceleration

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hidding, B.; Rosenzweig, J. B.; Xi, Y.

2012-12-21

An overview on the underlying principles of the hybrid plasma wakefield acceleration scheme dubbed 'Trojan Horse' acceleration is given. The concept is based on laser-controlled release of electrons directly into a particle-beam-driven plasma blowout, paving the way for controlled, shapeable electron bunches with ultralow emittance and ultrahigh brightness. Combining the virtues of a low-ionization-threshold underdense photocathode with the GV/m-scale electric fields of a practically dephasing-free beam-driven plasma blowout, this constitutes a 4th generation electron acceleration scheme. It is applicable as a beam brightness transformer for electron bunches from LWFA and PWFA systems alike. At FACET, the proof-of-concept experiment 'E-210: Trojanmore » Horse Plasma Wakefield Acceleration' has recently been approved and is in preparation. At the same time, various LWFA facilities are currently considered to host experiments aiming at stabilizing and boosting the electron bunch output quality via a trojan horse afterburner stage. Since normalized emittance and brightness can be improved by many orders of magnitude, the scheme is an ideal candidate for light sources such as free-electron-lasers and those based on Thomson scattering and betatron radiation alike.« less

Cryogenics for high-energy particle accelerators: highlights from the first fifty years

NASA Astrophysics Data System (ADS)

Lebrun, Ph

2017-02-01

Applied superconductivity has become a key technology for high-energy particle accelerators, allowing to reach higher beam energy while containing size, capital expenditure and operating costs. Large and powerful cryogenic systems are therefore ancillary to low-temperature superconducting accelerator devices - magnets and high-frequency cavities - distributed over multi-kilometre distances and operating generally close to the normal boiling point of helium, but also above 4.2 K in supercritical and down to below 2 K in superfluid. Additionally, low-temperature operation in accelerators may also be required by considerations of ultra-high vacuum, limited stored energy and beam stability. We discuss the rationale for cryogenics in high-energy particle accelerators, review its development over the past half-century and present its outlook in future large projects, with reference to the main engineering domains of cryostat design and heat loads, cooling schemes, efficient power refrigeration and cryogenic fluid management.

Uniformly accelerated black holes

NASA Astrophysics Data System (ADS)

Letelier, Patricio S.; Oliveira, Samuel R.

2001-09-01

The static and stationary C metric are examined in a generic framework and their interpretations studied in some detail, especially those with two event horizons, one for the black hole and another for the acceleration. We find that (i) the spacetime of an accelerated static black hole is plagued by either conical singularities or a lack of smoothness and compactness of the black hole horizon, (ii) by using standard black hole thermodynamics we show that accelerated black holes have a higher Hawking temperature than Unruh temperature of the accelerated frame, and (iii) the usual upper bound on the product of the mass and acceleration parameters (<1/27) is just a coordinate artifact. The main results are extended to accelerated rotating black holes with no significant changes.

Experimental Study of Proton Acceleration from Ultra Intense Laser Matter Interactions

NASA Astrophysics Data System (ADS)

Paudel, Yadab Kumar

This dissertation describes proton and ion acceleration measurements from high intensity (˜ 1019 Wcm-2) laser interactions with thin foil targets. Protons and ions accelerated from the back surface of a target driven by a high intensity laser are detected using solid-state nuclear track detector CR39. A simple digital imaging technique, with an adjustable halogen light source shined on CR39 and use of a digital camera with suitable f-number and exposure time, is used to detect particles tracks. This new technique improves the quality 2D image with vivid track patterns in CR39. Our technique allows us to quickly record and sort CR39 pieces for further analysis. This is followed by detailed quantitative information on the protons and ions. Protons and multicharged ions generated from high-intensity laser interactions with thin foil targets have been studied with a 100 TW laser system. Protons/ions with energies up to 10 MeV are accelerated either from the front or the rear surface of the target material. We have observed for the first time a self-radiograph of the target with a glass stalk holding the target itself in the stacked radiochromic films (RCF) placed behind the target. The self-radiography indicates that the fast ions accelerated backward, in a direction opposite to the laser propagation, are turning around in strong magnetic fields. This unique result is a signature of long-living (ns time scale) magnetic fields in the expanding plasma, which are important in energy transport during the intense laser irradiation and have never been considered in the previous studies. The magnetic fields induced by the main pulse near the absorption point expand rapidly with the backward accelerated protons in the pre-formed plasma. The protons are rotated by these magnetic fields and they are recorded in the RCF, making the self-radiography. Angular profiles of protons and multicharged ions accelerated from the target rear surface have been studied with the subpicosecond

Discovering the Meaning of Unity of Purpose: A Case Study of Fourteen Accelerated Schools.

ERIC Educational Resources Information Center

Davidson, Betty M.; Dell, Geralyn L.

This paper presents findings of a study that examined how teachers restructuring schools came to understand the meaning of the term "unity of purpose." Fourteen Louisiana schools, comprised primarily of high-risk student populations, implemented the accelerated-schools model of restructuring. The accelerated school model is based on…

Wave-Particle Interactions and Particle Acceleration in Turbulent Plasmas: Hybrid Simulations

NASA Astrophysics Data System (ADS)

Kucharek, Harald; Pogorelov, Nikolai; Mueller, Hans; Gamayunov, Konstantin; Farrugia, Charles

2015-04-01

Wave-particle interactions and acceleration processes are present in all key regions inside and outside of the heliosphere. Spacecraft observations measure ion distributions and accelerated ion populations, which are the result of one or several processes. For instance STEREO measures energetic particles associated with interplanetary discontinuities and in the solar wind. Voyager and IBEX provide unique data of energetic particles from the termination shock and the inner and outer heliopause. The range of plasma conditions covered by observations is enormous. However, the physical processes causing particle acceleration and wave-particle interaction and determining the particle distributions are still unknown. Currently two mechanisms, the so-called pumping mechanism (Fisk and Gloeckler, 2010) and merging/contracting island (Fermo, Drake & Swisdak, 2010) are discussed as promising models. In order to determine these individual processes, numerical models or theoretical considerations are needed. Hybrid simulations, which include all kinetic processes self-consistently on the ion level, are a very proven, powerful tool to investigate wave-particle interaction, turbulence, and phase-space evolution of pickup and solar wind ions. In the framework of this study we performed 3D multi-species hybrid simulations for an ion/ion beam instability to study the temporal evolution of ion distributions, their stability, and the influence of self-generated waves. We investigated the energization of ions downstream of interplanetary discontinuities and shocks and downstream of the termination shock, the turbulence, and growth rate of instabilities and compared the results with theoretical predictions. The simulations show that ions can be accelerated downstream of collisionless shocks by trapping of charged particles in coherent wave fronts.

Accelerating proof of concept for small molecule drugs using solid-state chemistry.

PubMed

Byrn, Stephen R; Zografi, George; Chen, Xiaoming Sean

2010-09-01

In this perspective we have shown that the process of "proof of concept" (POC) in the early part of drug development can be greatly accelerated by close attention to the underlying solid-state chemistry (SSC) of a new chemical entity. POC seeks data that provide confidence in the therapeutic activity and safety of a new chemical entity, which can rapidly lead to a key "GO/NO-GO" decision point for further development. Due to the high cost of the development of new chemical entities and the current low overall productivity of obtaining successful candidates, the pharmaceutical industry is being required to develop accelerated POC strategies. The success of accelerated approaches to POC depends on a full understanding of the SSC of drugs in relation to solubility and stability. Dissolution-limited absorption due to poor solubility of drug substances is particularly important because it can lead to low exposure in animals and undesired bioavailability in humans. Choosing a desirable solid form with sufficient solubility and acceptable stability is essential in developing formulations for POC with superior quality. In this perspective we present an approach that utilizes SSC as part of a novel 2-year development strategy for reaching the pivotal clinical trial stage of development.

Proposal for an Accelerator R&D User Facility at Fermilab's Advanced Superconducting Test Accelerator (ASTA)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Church, M.; Edwards, H.; Harms, E.

2013-10-01

Fermilab is the nation’s particle physics laboratory, supported by the DOE Office of High Energy Physics (OHEP). Fermilab is a world leader in accelerators, with a demonstrated track-record— spanning four decades—of excellence in accelerator science and technology. We describe the significant opportunity to complete, in a highly leveraged manner, a unique accelerator research facility that supports the broad strategic goals in accelerator science and technology within the OHEP. While the US accelerator-based HEP program is oriented toward the Intensity Frontier, which requires modern superconducting linear accelerators and advanced highintensity storage rings, there are no accelerator test facilities that support themore » accelerator science of the Intensity Frontier. Further, nearly all proposed future accelerators for Discovery Science will rely on superconducting radiofrequency (SRF) acceleration, yet there are no dedicated test facilities to study SRF capabilities for beam acceleration and manipulation in prototypic conditions. Finally, there are a wide range of experiments and research programs beyond particle physics that require the unique beam parameters that will only be available at Fermilab’s Advanced Superconducting Test Accelerator (ASTA). To address these needs we submit this proposal for an Accelerator R&D User Facility at ASTA. The ASTA program is based on the capability provided by an SRF linac (which provides electron beams from 50 MeV to nearly 1 GeV) and a small storage ring (with the ability to store either electrons or protons) to enable a broad range of beam-based experiments to study fundamental limitations to beam intensity and to develop transformative approaches to particle-beam generation, acceleration and manipulation which cannot be done elsewhere. It will also establish a unique resource for R&D towards Energy Frontier facilities and a test-bed for SRF accelerators and high brightness beam applications in support of the

Computational study of radiation doses at UNLV accelerator facility

NASA Astrophysics Data System (ADS)

Hodges, Matthew; Barzilov, Alexander; Chen, Yi-Tung; Lowe, Daniel

2017-09-01

A Varian K15 electron linear accelerator (linac) has been considered for installation at University of Nevada, Las Vegas (UNLV). Before experiments can be performed, it is necessary to evaluate the photon and neutron spectra as generated by the linac, as well as the resulting dose rates within the accelerator facility. A computational study using MCNPX was performed to characterize the source terms for the bremsstrahlung converter. The 15 MeV electron beam available in the linac is above the photoneutron threshold energy for several materials in the linac assembly, and as a result, neutrons must be accounted for. The angular and energy distributions for bremsstrahlung flux generated by the interaction of the 15 MeV electron beam with the linac target were determined. This source term was used in conjunction with the K15 collimators to determine the dose rates within the facility.

N-dimensional hypervolumes to study stability of complex ecosystems

PubMed Central

Barros, Ceres; Thuiller, Wilfried; Georges, Damien; Boulangeat, Isabelle; Münkemüller, Tamara

2016-01-01

Although our knowledge on the stabilising role of biodiversity and on how it is affected by perturbations has greatly improved, we still lack a comprehensive view on ecosystem stability that is transversal to different habitats and perturbations. Hence, we propose a framework that takes advantage of the multiplicity of components of an ecosystem and their contribution to stability. Ecosystem components can range from species or functional groups, to different functional traits, or even the cover of different habitats in a landscape mosaic. We make use of n-dimensional hypervolumes to define ecosystem states and assess how much they shift after environmental changes have occurred. We demonstrate the value of this framework with a study case on the effects of environmental change on Alpine ecosystems. Our results highlight the importance of a multidimensional approach when studying ecosystem stability and show that our framework is flexible enough to be applied to different types of ecosystem components, which can have important implications for the study of ecosystem stability and transient dynamics. PMID:27282314

N-dimensional hypervolumes to study stability of complex ecosystems.

PubMed

Barros, Ceres; Thuiller, Wilfried; Georges, Damien; Boulangeat, Isabelle; Münkemüller, Tamara

2016-07-01

Although our knowledge on the stabilising role of biodiversity and on how it is affected by perturbations has greatly improved, we still lack a comprehensive view on ecosystem stability that is transversal to different habitats and perturbations. Hence, we propose a framework that takes advantage of the multiplicity of components of an ecosystem and their contribution to stability. Ecosystem components can range from species or functional groups, to different functional traits, or even the cover of different habitats in a landscape mosaic. We make use of n-dimensional hypervolumes to define ecosystem states and assess how much they shift after environmental changes have occurred. We demonstrate the value of this framework with a study case on the effects of environmental change on Alpine ecosystems. Our results highlight the importance of a multidimensional approach when studying ecosystem stability and show that our framework is flexible enough to be applied to different types of ecosystem components, which can have important implications for the study of ecosystem stability and transient dynamics. © 2016 John Wiley & Sons Ltd/CNRS.

Trunk acceleration for neuroprosthetic control of standing: a pilot study.

PubMed

Nataraj, Raviraj; Audu, Musa L; Kirsch, Robert F; Triolo, Ronald J

2012-02-01

This pilot study investigated the potential of using trunk acceleration feedback control of center of pressure (COP) against postural disturbances with a standing neuroprosthesis following paralysis. Artificial neural networks (ANNs) were trained to use three-dimensional trunk acceleration as input to predict changes in COP for able-bodied subjects undergoing perturbations during bipedal stance. Correlation coefficients between ANN predictions and actual COP ranged from 0.67 to 0.77. An ANN trained across all subject-normalized data was used to drive feedback control of ankle muscle excitation levels for a computer model representing a standing neuroprosthesis user. Feedback control reduced average upper-body loading during perturbation onset and recovery by 42% and peak loading by 29% compared with optimal, constant excitation.

Dynamic stabilization of rapid hexapedal locomotion.

PubMed

Jindrich, Devin L; Full, Robert J

2002-09-01

To stabilize locomotion, animals must generate forces appropriate to overcome the effects of perturbations and to maintain a desired speed or direction of movement. We studied the stabilizing mechanism employed by rapidly running insects by using a novel apparatus to perturb running cockroaches (Blaberus discoidalis). The apparatus used chemical propellants to accelerate a small projectile, generating reaction force impulses of less than 10 ms duration. The apparatus was mounted onto the thorax of the insect, oriented to propel the projectile laterally and loaded with propellant sufficient to cause a nearly tenfold increase in lateral velocity relative to maxima observed during unperturbed locomotion. Cockroaches were able to recover from these perturbations in 27+/-12 ms (mean +/- S.D., N=9) when running on a high-friction substratum. Lateral velocity began to decrease 13+/-5 ms (mean +/- S.D., N=11) following the start of a perturbation, a time comparable with the fastest reflexes measured in cockroaches. Cockroaches did not require step transitions to recover from lateral perturbations. Instead, they exhibited viscoelastic behavior in the lateral direction, with spring constants similar to those observed during unperturbed locomotion. The rapid onset of recovery from lateral perturbations supports the possibility that, during fast locomotion, intrinsic properties of the musculoskeletal system augment neural stabilization by reflexes.

Effects of Frequency and Acceleration Amplitude on Osteoblast Mechanical Vibration Responses: A Finite Element Study

PubMed Central

Hsu, Hung-Yao

2016-01-01

Bone cells are deformed according to mechanical stimulation they receive and their mechanical characteristics. However, how osteoblasts are affected by mechanical vibration frequency and acceleration amplitude remains unclear. By developing 3D osteoblast finite element (FE) models, this study investigated the effect of cell shapes on vibration characteristics and effect of acceleration (vibration intensity) on vibrational responses of cultured osteoblasts. Firstly, the developed FE models predicted natural frequencies of osteoblasts within 6.85–48.69 Hz. Then, three different levels of acceleration of base excitation were selected (0.5, 1, and 2 g) to simulate vibrational responses, and acceleration of base excitation was found to have no influence on natural frequencies of osteoblasts. However, vibration response values of displacement, stress, and strain increased with the increase of acceleration. Finally, stress and stress distributions of osteoblast models under 0.5 g acceleration in Z-direction were investigated further. It was revealed that resonance frequencies can be a monotonic function of cell height or bottom area when cell volumes and material properties were assumed as constants. These findings will be useful in understanding how forces are transferred and influence osteoblast mechanical responses during vibrations and in providing guidance for cell culture and external vibration loading in experimental and clinical osteogenesis studies. PMID:28074178

Silica nanoparticle stability in biological media revisited.

PubMed

Yang, Seon-Ah; Choi, Sungmoon; Jeon, Seon Mi; Yu, Junhua

2018-01-09

The stability of silica nanostructure in the core-silica shell nanomaterials is critical to understanding the activity of these nanomaterials since the exposure of core materials due to the poor stability of silica may cause misinterpretation of experiments, but unfortunately reports on the stability of silica have been inconsistent. Here, we show that luminescent silver nanodots (AgNDs) can be used to monitor the stability of silica nanostructures. Though relatively stable in water and phosphate buffered saline, silica nanoparticles are eroded by biological media, leading to the exposure of AgNDs from AgND@SiO 2 nanoparticles and the quenching of nanodot luminescence. Our results reveal that a synergistic effect of organic compounds, particularly the amino groups, accelerates the erosion. Our work indicates that silica nanostructures are vulnerable to cellular medium and it may be possible to tune the release of drug molecules from silica-based drug delivery vehicles through controlled erosion.

Atomic References for Measuring Small Accelerations

NASA Technical Reports Server (NTRS)

Maleki, Lute; Yu, Nan

2009-01-01

Accelerometer systems that would combine the best features of both conventional (e.g., mechanical) accelerometers and atom interferometer accelerometers (AIAs) have been proposed. These systems are intended mainly for use in scientific research aboard spacecraft but may also be useful on Earth in special military, geological, and civil-engineering applications. Conventional accelerometers can be sensitive, can have high dynamic range, and can have high frequency response, but they lack accuracy and long-term stability. AIAs have low frequency response, but they offer high sensitivity, and high accuracy for measuring small accelerations. In a system according to the proposal, a conventional accelerometer would be used to perform short-term measurements of higher-frequency components of acceleration, while an AIA would be used to provide consistent calibration of, and correction of errors in, the measurements of the conventional accelerometer in the lower-frequency range over the long term. A brief description of an AIA is prerequisite to a meaningful description of a system according to the proposal. An AIA includes a retroreflector next to one end of a cell that contains a cold cloud of atoms in an ultrahigh vacuum. The atoms in the cloud are in free fall. The retroreflector is mounted on the object, the acceleration of which is to be measured. Raman laser beams are directed through the cell from the end opposite the retroreflector, then pass back through the cell after striking the retroreflector. The Raman laser beams together with the cold atoms measure the relative acceleration, through the readout of the AIA, between the cold atoms and the retroreflector.

STUDIES OF A FREE ELECTRON LASER DRIVEN BY A LASER-PLASMA ACCELERATOR

DOE Office of Scientific and Technical Information (OSTI.GOV)

Montgomery, A.; Schroeder, C.; Fawley, W.

A free electron laser (FEL) uses an undulator, a set of alternating magnets producing a periodic magnetic fi eld, to stimulate emission of coherent radiation from a relativistic electron beam. The Lasers, Optical Accelerator Systems Integrated Studies (LOASIS) group at Lawrence Berkeley National Laboratory (LBNL) will use an innovative laserplasma wakefi eld accelerator to produce an electron beam to drive a proposed FEL. In order to optimize the FEL performance, the dependence on electron beam and undulator parameters must be understood. Numerical modeling of the FEL using the simulation code GINGER predicts the experimental results for given input parameters. Amongmore » the parameters studied were electron beam energy spread, emittance, and mismatch with the undulator focusing. Vacuum-chamber wakefi elds were also simulated to study their effect on FEL performance. Energy spread was found to be the most infl uential factor, with output FEL radiation power sharply decreasing for relative energy spreads greater than 0.33%. Vacuum chamber wakefi elds and beam mismatch had little effect on the simulated LOASIS FEL at the currents considered. This study concludes that continued improvement of the laser-plasma wakefi eld accelerator electron beam will allow the LOASIS FEL to operate in an optimal regime, producing high-quality XUV and x-ray pulses.« less

Cell culture media impact on drug product solution stability.

PubMed

Purdie, Jennifer L; Kowle, Ronald L; Langland, Amie L; Patel, Chetan N; Ouyang, Anli; Olson, Donald J

2016-07-08

To enable subcutaneous administration of monoclonal antibodies, drug product solutions are often needed at high concentrations. A significant risk associated with high drug product concentrations is an increase in aggregate level over the shelf-life dating period. While much work has been done to understand the impact of drug product formulation on aggregation, there is limited understanding of the link between cell culture process conditions and soluble aggregate growth in drug product. During cell culture process development, soluble aggregates are often measured at harvest using cell-free material purified by Protein A chromatography. In the work reported here, cell culture media components were evaluated with respect to their impact on aggregate levels in high concentration solution drug product during accelerated stability studies. Two components, cysteine and ferric ammonium citrate, were found to impact aggregate growth rates in our current media (version 1) leading to the development of new chemically defined media and concentrated feed formulations. The new version of media and associated concentrated feeds (version 2) were evaluated across four cell lines producing recombinant IgG4 monoclonal antibodies and a bispecific antibody. In all four cell lines, the version 2 media reduced aggregate growth over the course of a 12 week accelerated stability study compared with the version 1 media, although the degree to which aggregate growth decreased was cell line dependent. © 2016 American Institute of Chemical Engineers Biotechnol. Prog., 32:998-1008, 2016. © 2016 American Institute of Chemical Engineers.

Resilience and stability of a pelagic marine ecosystem

PubMed Central

Lindegren, Martin; Checkley, David M.; Ohman, Mark D.; Koslow, J. Anthony; Goericke, Ralf

2016-01-01

The accelerating loss of biodiversity and ecosystem services worldwide has accentuated a long-standing debate on the role of diversity in stabilizing ecological communities and has given rise to a field of research on biodiversity and ecosystem functioning (BEF). Although broad consensus has been reached regarding the positive BEF relationship, a number of important challenges remain unanswered. These primarily concern the underlying mechanisms by which diversity increases resilience and community stability, particularly the relative importance of statistical averaging and functional complementarity. Our understanding of these mechanisms relies heavily on theoretical and experimental studies, yet the degree to which theory adequately explains the dynamics and stability of natural ecosystems is largely unknown, especially in marine ecosystems. Using modelling and a unique 60-year dataset covering multiple trophic levels, we show that the pronounced multi-decadal variability of the Southern California Current System (SCCS) does not represent fundamental changes in ecosystem functioning, but a linear response to key environmental drivers channelled through bottom-up and physical control. Furthermore, we show strong temporal asynchrony between key species or functional groups within multiple trophic levels caused by opposite responses to these drivers. We argue that functional complementarity is the primary mechanism reducing community variability and promoting resilience and stability in the SCCS. PMID:26763697

Scalability of the LEU-Modified Cintichem Process: 3-MeV Van de Graaff and 35-MeV Electron Linear Accelerator Studies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rotsch, David A.; Brossard, Tom; Roussin, Ethan

Molybdenum-99, the mother of Tc-99m, can be produced from fission of U-235 in nuclear reactors and purified from fission products by the Cintichem process, later modified for low-enriched uranium (LEU) targets. The key step in this process is the precipitation of Mo with α-benzoin oxime (ABO). The stability of this complex to radiation has been examined. Molybdenum-ABO was irradiated with 3 MeV electrons produced by a Van de Graaff generator and 35 MeV electrons produced by a 50 MeV/25 kW electron linear accelerator. Dose equivalents of 1.7–31.2 kCi of Mo-99 were administered to freshly prepared Mo-ABO. Irradiated samples of Mo-ABOmore » were processed according to the LEU Modified-Cintichem process. The Van de Graaff data indicated good radiation stability of the Mo-ABO complex up to ~15 kCi dose equivalents of Mo-99 and nearly complete destruction at doses >24 kCi Mo-99. The linear accelerator data indicate that even at 6.2 kCi of Mo-99 equivalence of dose, the sample lost ~20% of Mo-99. The 20% loss of Mo-99 at this low dose may be attributed to thermal decomposition of the product from the heat deposited in the sample during irradiation.« less

Studies of Ion Acceleration from Thin Solid-Density Targets on High-Intensity Lasers

NASA Astrophysics Data System (ADS)

Willis, Christopher R.

Over the past two decades, a number of experiments have been performed demonstrating the acceleration of ions from the interaction of an intense laser pulse with a thin, solid density target. These ions are accelerated by quasi-static electric fields generated by energetic electrons produced at the front of the target, resulting in ion energies up to tens of MeV. These ions have been widely studied for a variety of potential applications ranging from treatment of cancer to the production of neutrons for advanced radiography techniques. However, realization of these applications will require further optimization of the maximum energy, spectrum, or species of the accelerated ions, which has been a primary focus of research to date. This thesis presents two experiments designed to optimize several characteristics of the accelerated ion beam. The first of these experiments took place on the GHOST laser system at the University of Texas at Austin, and was designed to demonstrate reliable acceleration of deuterium ions, as needed for the most efficient methods of neutron generation from accelerated ions. This experiment leveraged cryogenically cooled targets coated in D2 O ice to suppress the protons which typically dominate the accelerated ions, producing as many as 2 x 1010 deuterium ions per 1 J laser shot, exceeding the proton yield by an average ratio of 5:1. The second major experiment in this work was performed on the Scarlet laser system at The Ohio State University, and studied the accelerated ion energy, yield, and spatial distribution as a function of the target thickness. In principle, the peak energy increases with decreasing target thickness, with the thinnest targets accessing additional acceleration mechanisms which provide favorable scaling with the laser intensity. However, laser prepulse characteristics provide a lower bound for the target thickness, yielding an optimum target thickness for ion acceleration which is dependent on the laser system. This

Motion sickness and otolith sensitivity - A pilot study of habituation to linear acceleration

NASA Technical Reports Server (NTRS)

Potvin, A. R.; Sadoff, M.; Billingham, J.

1977-01-01

Astronauts, particularly in Skylab flights, experienced varying degrees of motion sickness lasting 3-5 days. One possible mechanism for this motion sickness adaptation is believed to be a reduction in otolith sensitivity with an attendant reduction in sensory conflict. In an attempt to determine if this hypothesis is valid, a ground-based pilot study was conducted on a vertical linear accelerator. The extent of habituation to accelerations which initially produced motion sickness was evaluated, along with the possible value of habituation training to minimize the space motion sickness problem. Results showed that habituation occurred for 6 of the 8 subjects tested. However, in tests designed to measure dynamic and static otolith function, no significant differences between pre- and post-habituation tests were observed. Cross habituation effects to a standard Coriolis acceleration test were not significant. It is unlikely that ground-based pre-habituation to linear accelerations of the type examined would alter susceptibility to space motion sickness.

Nonlocal Models of Cosmic Acceleration

NASA Astrophysics Data System (ADS)

Woodard, R. P.

2014-02-01

I review a class of nonlocally modified gravity models which were proposed to explain the current phase of cosmic acceleration without dark energy. Among the topics considered are deriving causal and conserved field equations, adjusting the model to make it support a given expansion history, why these models do not require an elaborate screening mechanism to evade solar system tests, degrees of freedom and kinetic stability, and the negative verdict of structure formation. Although these simple models are not consistent with data on the growth of cosmic structures many of their features are likely to carry over to more complicated models which are in better agreement with the data.

Evolutionary optimization methods for accelerator design

NASA Astrophysics Data System (ADS)

Poklonskiy, Alexey A.

optimization test problems for EA with a variety of different configurations and suggest optimal default parameter values based on the results. Then we study the performance of the REPA method on the same set of test problems and compare the obtained results with those of several commonly used constrained optimization methods with EA. Based on the obtained results, particularly on the outstanding performance of REPA on test problem that presents significant difficulty for other reviewed EAs, we conclude that the proposed method is useful and competitive. We discuss REPA parameter tuning for difficult problems and critically review some of the problems from the de-facto standard test problem set for the constrained optimization with EA. In order to demonstrate the practical usefulness of the developed method, we study several problems of accelerator design and demonstrate how they can be solved with EAs. These problems include a simple accelerator design problem (design a quadrupole triplet to be stigmatically imaging, find all possible solutions), a complex real-life accelerator design problem (an optimization of the front end section for the future neutrino factory), and a problem of the normal form defect function optimization which is used to rigorously estimate the stability of the beam dynamics in circular accelerators. The positive results we obtained suggest that the application of EAs to problems from accelerator theory can be very beneficial and has large potential. The developed optimization scenarios and tools can be used to approach similar problems.

Detecting chaos in particle accelerators through the frequency map analysis method.

PubMed

Papaphilippou, Yannis

2014-06-01

The motion of beams in particle accelerators is dominated by a plethora of non-linear effects, which can enhance chaotic motion and limit their performance. The application of advanced non-linear dynamics methods for detecting and correcting these effects and thereby increasing the region of beam stability plays an essential role during the accelerator design phase but also their operation. After describing the nature of non-linear effects and their impact on performance parameters of different particle accelerator categories, the theory of non-linear particle motion is outlined. The recent developments on the methods employed for the analysis of chaotic beam motion are detailed. In particular, the ability of the frequency map analysis method to detect chaotic motion and guide the correction of non-linear effects is demonstrated in particle tracking simulations but also experimental data.

Influence of particle shedding from silicone tubing on antibody stability.

PubMed

Saller, Verena; Hediger, Constanze; Matilainen, Julia; Grauschopf, Ulla; Bechtold-Peters, Karoline; Mahler, Hanns-Christian; Friess, Wolfgang

2018-05-01

Peristaltic pumps are increasingly employed during fill & finish operations of a biopharmaceutical drug, due to sensitivity of many biological products to rotary piston pump-related stresses. Yet, possibly also unit operations using peristaltic pumps may shed particulates into the final product due to abrasion from the employed tubing. It was the aim of this study to elucidate the potential influence of particles shed from peristaltic pump tubing on the stability of a drug product. Spiking solutions containing shed silicone particles were prepared via peristaltic pumping of placebo under recirculating conditions and subsequently characterized. Two formulated antibodies were spiked with two realistic, but worst-case levels of particles and a 6-month accelerated stability study with storage at 2-8, 25 and 40°C were conducted. Regarding the formation of aggregates and fragments, both mAbs degraded at their typically expected rates and no additional impact of spiked particles was observed. No changes were discerned however in turbidity, subvisible and visible particle assessments. Flow imaging data for one of the mAb formulations with spiked particles suggested limited colloidal stability of shed particles as indicated by a similar increase in spiked placebo. Shed silicone particles from peristaltic pump tubing are assumed to not impair drug product stability. © 2016 Royal Pharmaceutical Society.

Laser Wakefield Acceleration: Structural and Dynamic Studies. Final Technical Report ER40954

DOE Office of Scientific and Technical Information (OSTI.GOV)

Downer, Michael C.

2014-04-30

Particle accelerators enable scientists to study the fundamental structure of the universe, but have become the largest and most expensive of scientific instruments. In this project, we advanced the science and technology of laser-plasma accelerators, which are thousands of times smaller and less expensive than their conventional counterparts. In a laser-plasma accelerator, a powerful laser pulse exerts light pressure on an ionized gas, or plasma, thereby driving an electron density wave, which resembles the wake behind a boat. Electrostatic fields within this plasma wake reach tens of billions of volts per meter, fields far stronger than ordinary non-plasma matter (suchmore » as the matter that a conventional accelerator is made of) can withstand. Under the right conditions, stray electrons from the surrounding plasma become trapped within these “wake-fields”, surf them, and acquire energy much faster than is possible in a conventional accelerator. Laser-plasma accelerators thus might herald a new generation of compact, low-cost accelerators for future particle physics, x-ray and medical research. In this project, we made two major advances in the science of laser-plasma accelerators. The first of these was to accelerate electrons beyond 1 gigaelectronvolt (1 GeV) for the first time. In experimental results reported in Nature Communications in 2013, about 1 billion electrons were captured from a tenuous plasma (about 1/100 of atmosphere density) and accelerated to 2 GeV within about one inch, while maintaining less than 5% energy spread, and spreading out less than ½ milliradian (i.e. ½ millimeter per meter of travel). Low energy spread and high beam collimation are important for applications of accelerators as coherent x-ray sources or particle colliders. This advance was made possible by exploiting unique properties of the Texas Petawatt Laser, a powerful laser at the University of Texas at Austin that produces pulses of 150 femtoseconds (1 femtosecond

Feasibility Study of Improved Methods for Riverbank Stabilization

DTIC Science & Technology

1964-11-01

hose materials which appear to be technically feasible for such applications are listed in Tables I - 1 and I - 2. I-9 Artificial Riprap...the uncompacted asphalt pavement. Those which 1-11 show the most potential for further study are soil cement, synthetic elastomer sheeting, and...uncompated asphalt pavement. Chemical soil stabilization and metal sheeting are too exp~nsive, and the quality of chemically stabilized soil protection is

Experimental and theoretical studies of the colloidal stability of nanoparticles-a general interpretation based on stability maps.

PubMed

Segets, Doris; Marczak, Renata; Schäfer, Stefan; Paula, Carolin; Gnichwitz, Jan-Frederik; Hirsch, Andreas; Peukert, Wolfgang

2011-06-28

The current work addresses the understanding of the stabilization of nanoparticles in suspension. Specifically, we study ZnO in ethanol for which the influence of particle size and reactant ratio as well as surface coverage on colloidal stability in dependence of the purification progress was investigated. The results revealed that the well-known ζ-potential determines not only the colloidal stability but also the surface coverage of acetate groups bound to the particle surface. The acetate groups act as molecular spacers between the nanoparticles and prevent agglomeration. Next to DLVO calculations based on the theory of Derjaguin, Landau, Verwey and Overbeek using a core-shell model we find that the stability is better understood in terms of dimensionless numbers which represent attractive forces as well as electrostatic repulsion, steric effects, transport properties, and particle concentration. Evaluating the colloidal stability in dependence of time by means of UV-vis absorption measurements a stability map for ZnO is derived. From this map it becomes clear that the dimensionless steric contribution to colloidal stability scales with a stability parameter including dimensionless repulsion and attraction as well as particle concentration and diffusivity of the particles according to a power law with an exponent of -0.5. Finally, we show that our approach is valid for other stabilizing molecules like cationic dendrons and is generally applicable for a wide range of other material systems within the limitations of vanishing van der Waals forces in refractive index matched situations, vanishing ζ-potential and systems without a stabilizing shell around the particle surface.

Accelerated loading evaluation of stabilized BCS layers in pavement performance : tech summary.

DOT National Transportation Integrated Search

2012-03-01

The Louisiana Department of Transportation and Development (LADOTD) began to use blended calcium sulfate (BCS) as : an alternative base material in the 1990s. Raw BCS base without further chemical stabilization can achieve relatively high : strength ...

Accelerated recovery after cardiac operations.

PubMed

Kaplan, Mehmet; Kut, Mustafa Sinan; Yurtseven, Nurgul; Cimen, Serdar; Demirtas, Mahmut Murat

2002-01-01

The accelerated-recovery approach, involving early extubation, early mobility, decreased duration of intensive care unit stay, and decreased duration of hospitalization has recently become a controversial issue in cardiac surgery. We investigated timing of extubation, length of intensive care unit stay, and duration of hospitalization in 225 consecutive cardiac surgery patients. Of the 225 patients, 139 were male and 86 were female; average age was 49.73 +/- 16.95 years. Coronary artery bypass grafting was performed in 127 patients; 65 patients underwent aortic and/or mitral or pulmonary valvular operations; 5 patients underwent valvular plus coronary artery operations; and in 28 patients surgical interventions for congenital anomalies were carried out. The accelerated-recovery approach could be applied in 169 of the 225 cases (75.11%). Accelerated-recovery patients were extubated after an average of 3.97 +/- 1.59 hours, and the average duration of stay in the intensive care unit was 20.93 +/- 2.44 hours for these patients. Patients were discharged if they met all of the following criteria: hemodynamic stability, cooperativeness, ability to initiate walking exercises within wards, lack of pathology in laboratory investigations, and psychological readiness for discharge. Mean duration of hospitalization for accelerated-recovery patients was 4.24 +/- 0.75 days. Two patients (1.18%) who were extubated within the first 6 hours required reintubation. Four patients (2.36%) who were sent to the wards returned to intensive care unit due to various reasons and 6 (3.55%) of the discharged patients were rehospitalized. Approaches for decreasing duration of intubation, intensive care unit stay and hospitalization may be applied in elective and uncomplicated cardiac surgical interventions with short duration of aortic cross-clamping and cardiopulmonary bypass, without risking patients. Frequencies of reintubation, return to intensive care unit, and rehospitalization are quite

Self-perceived gait stability modulates the effect of daily life gait quality on prospective falls in older adults.

PubMed

Weijer, R H A; Hoozemans, M J M; van Dieën, J H; Pijnappels, M

2018-05-01

Quality of gait during daily life activities and perceived gait stability are both independent risk factors for future falls in older adults. We investigated whether perceived gait stability modulates the association between gait quality and falling in older adults. In this prospective cohort study, we used one-week daily-life trunk acceleration data of 272 adults over 65 years of age. Sample entropy (SE) of the 3D acceleration signals was calculated to quantify daily life gait quality. To quantify perceived gait stability, the level of concern about falling was assessed using the Falls Efficacy Scale international (FES-I) questionnaire and step length, estimated from the accelerometer data. A fall calendar was used to record fall incidence during a six-month follow up period. Logistic regression analyses were performed to study the association between falling and SE, step length or FES-I score, and their interactions. High (i.e., poor) SE in vertical direction was significantly associated with falling. FES-I scores significantly modulated this association, whereas step length did not. Subgroup analyses based on FES-I scores showed that high SE in the vertical direction was a risk factor for falls only in older adults who had a high (i.e. poor) FES-I score. In conclusion, perceived gait stability modulates the association between gait quality and falls in older adults such that an association between gait quality and falling is only present when perceived gait stability is poor. The results of the present study indicate that the effectiveness of interventions for fall prevention, aimed at improving gait quality, may be affected by a modulating effect of perceived gait stability. Results indicate that interventions to reduce falls in older adults might sort most effectiveness in populations with both a poor physiological and psychological status. Copyright © 2018 Elsevier B.V. All rights reserved.

Simulation Studies of the Dielectric Grating as an Accelerating and Focusing Structure

DOE Office of Scientific and Technical Information (OSTI.GOV)

Soong, Ken; Peralta, E.A.; Byer, R.L.

A grating-based design is a promising candidate for a laser-driven dielectric accelerator. Through simulations, we show the merits of a readily fabricated grating structure as an accelerating component. Additionally, we show that with a small design perturbation, the accelerating component can be converted into a focusing structure. The understanding of these two components is critical in the successful development of any complete accelerator. The concept of accelerating electrons with the tremendous electric fields found in lasers has been proposed for decades. However, until recently the realization of such an accelerator was not technologically feasible. Recent advances in the semiconductor industry,more » as well as advances in laser technology, have now made laser-driven dielectric accelerators imminent. The grating-based accelerator is one proposed design for a dielectric laser-driven accelerator. This design, which was introduced by Plettner, consists of a pair of opposing transparent binary gratings, illustrated in Fig. 1. The teeth of the gratings serve as a phase mask, ensuring a phase synchronicity between the electromagnetic field and the moving particles. The current grating accelerator design has the drive laser incident perpendicular to the substrate, which poses a laser-structure alignment complication. The next iteration of grating structure fabrication seeks to monolithically create an array of grating structures by etching the grating's vacuum channel into a fused silica wafer. With this method it is possible to have the drive laser confined to the plane of the wafer, thus ensuring alignment of the laser-and-structure, the two grating halves, and subsequent accelerator components. There has been previous work using 2-dimensional finite difference time domain (2D-FDTD) calculations to evaluate the performance of the grating accelerator structure. However, this work approximates the grating as an infinite structure and does not accurately model a

Stabilization of anthocyanins in blackberry juice by glutathione fortification.

PubMed

Stebbins, Nathan B; Howard, Luke R; Prior, Ronald L; Brownmiller, Cindi; Mauromoustakos, Andy

2017-10-18

Blackberry anthocyanins provide attractive color and antioxidant activity. However, anthocyanins degrade during juice processing and storage, so maintaining high anthocyanin concentrations in berry juices may lead to greater antioxidant and health benefits for the consumer. This study evaluated potential additives to stabilize anthocyanins during blackberry juice storage. The anthocyanin stabilizing agents used were: glutathione, galacturonic acid, diethylenetriaminepentaacetic acid and tannic acid, which were added at a level of 500 mg L -1 . Juice anthocyanin, flavonol, and ellagitannin content and percent polymeric color were measured over five weeks of accelerated storage at 30 °C. Glutathione had the greatest protective effect on total anthocyanins and polymeric color. Therefore a second study was performed with glutathione in combination with lipoic and ascorbic acids in an effort to use antioxidant recycling to achieve a synergistic effect. However, the antioxidant recycling system had no protective effect relative to glutathione alone. Glutathione appears to be a promising blackberry juice additive to protect against anthocyanin degradation during storage.

Study of an External Neutron Source for an Accelerator-Driven System using the PHITS Code

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sugawara, Takanori; Iwasaki, Tomohiko; Chiba, Takashi

A code system for the Accelerator Driven System (ADS) has been under development for analyzing dynamic behaviors of a subcritical core coupled with an accelerator. This code system named DSE (Dynamics calculation code system for a Subcritical system with an External neutron source) consists of an accelerator part and a reactor part. The accelerator part employs a database, which is calculated by using PHITS, for investigating the effect related to the accelerator such as the changes of beam energy, beam diameter, void generation, and target level. This analysis method using the database may introduce some errors into dynamics calculations sincemore » the neutron source data derived from the database has some errors in fitting or interpolating procedures. In this study, the effects of various events are investigated to confirm that the method based on the database is appropriate.« less

Electrochemical oxidation coupled with liquid chromatography and mass spectrometry to study the oxidative stability of active pharmaceutical ingredients in solution: A comparison of off-line and on-line approaches.

PubMed

Torres, Susana; Brown, Roland; Zelesky, Todd; Scrivens, Garry; Szucs, Roman; Hawkins, Joel M; Taylor, Mark R

2016-11-30

Stability studies of pharmaceutical drug products and pharmaceutical active substances are important to research and development in order to fully understand and maintain product quality and safety throughout its shelf-life. Oxidative forced degradation studies are among the different types of stability studies performed by the pharmaceutical industry in order to understand the intrinsic stability of drug molecules. We have been comparing the use of electrochemistry as an alternative oxidative forced degradation method to traditional forced degradation and accelerated stability studies. Using the electrochemical degradation approach the substrate oxidation takes place in a commercially available electrochemical cell and the effluent of the cell can be either a) directly infused into the mass spectrometer or b) injected in a chromatographic column for separation of the different products formed prior to the mass spectrometry analysis. To enable the study of large numbers of different experimental conditions and molecules we developed a new dual pump automated electrochemical screening platform. This system used a HPLC pump and autosampler to load and wash the electrochemical cell and deliver the oxidized sample plug to a second injection loop. This system enabled the automatic sequential analyses of large numbers of different solutions under varied experimental conditions without need for operator intervention during the run sequence. Here we describe the system and evaluate its performance using a test molecule with well characterized stability and compare results to those obtained using an off-line electrochemistry approach. Copyright © 2016 Elsevier B.V. All rights reserved.

Doping control container for urine stabilization: a pilot study.

PubMed

Tsivou, Maria; Giannadaki, Evangelia; Hooghe, Fiona; Roels, Kris; Van Gansbeke, Wim; Garribba, Flaminia; Lyris, Emmanouil; Deventer, Koen; Mazzarino, Monica; Donati, Francesco; Georgakopoulos, Dimitrios G; Van Eenoo, Peter; Georgakopoulos, Costas G; de la Torre, Xavier; Botrè, Francesco

2017-05-01

Urine collection containers used in the doping control collection procedure do not provide a protective environment for urine, against degradation by microorganisms and proteolytic enzymes. An in-house chemical stabilization mixture was developed to tackle urine degradation problems encountered in human sport samples, in cases of microbial contamination or proteolytic activity. The mixture consists of antimicrobial substances and protease inhibitors for the simultaneous inactivation of a wide range of proteolytic enzymes. It has already been tested in lab-scale, as part of World Anti-Doping Agency's (WADA) funded research project, in terms of efficiency against microbial and proteolytic activity. The present work, funded also by WADA, is a follow-up study on the improvement of chemical stabilization mixture composition, application mode and limitation of interferences, using pilot urine collection containers, spray-coated in their internal surface with the chemical stabilization mixture. Urine in plastic stabilized collection containers have been gone through various incubation cycles to test for stabilization efficiency and analytical matrix interferences by three WADA accredited Laboratories (Athens, Ghent, and Rome). The spray-coated chemical stabilization mixture was tested against microorganism elimination and steroid glucuronide degradation, as well as enzymatic breakdown of proteins, such as intact hCG, recombinant erythropoietin and small peptides (GHRPs, ipamorelin), induced by proteolytic enzymes. Potential analytical interferences, observed in the presence of spray-coated chemical stabilization mixture, were recorded using routine screening procedures. The results of the current study support the application of the spray-coated plastic urine container, in the doping control collection procedure. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

Early Acceleration of Mathematics Students and its Effect on Growth in Self-esteem: A Longitudinal Study

NASA Astrophysics Data System (ADS)

Ma, Xin

2002-11-01

The Longitudinal Study of American Youth (LSAY) database was employed to examine the educational practice of early acceleration of students of mathematics on the development of their self-esteem across the entire secondary grade levels. Students were classified into three different academic categories (gifted, honors, and regular). Results indicated that, in terms of the development of their self-esteem, gifted students benefited from early acceleration, honors students neither benefited nor were harmed by early acceleration, and regular students were harmed by early acceleration. Early acceleration in mathematics promoted significant growth in self-esteem among gifted male students and among gifted, honors, and regular minority students. When students were accelerated, schools showed similar average growth in self-esteem among gifted students and regular students and a large effect of general support for mathematics on the average growth in self-esteem among honors students.

[Study on composite stabilization of arsenic (As) contaminated soil].

PubMed

Wang, Hao; Pan, Li-xiang; Zhang, Xiang-yu; Li, Meng; Song, Bao-hua

2013-09-01

Since the contaminated soil may contain various kinds of heavy metals, use of single chemical reagent leads to poor remediation and high cost. In this study, soil containing As, Zn, Cd was sampled, and different reagents were selected to carry out the rapid stabilization of contaminated soil. The TCLP (toxicity characteristic leaching procedure) was used to evaluate the leachate toxicity of heavy metals and the results indicated that calcium-containing, sulphur-containing and iron-containing reagents had good performance in reducing the metal mobility. The stabilization efficiency of the six reagents tested ranked in the order of CaO > Na2S > organic sulfur > Chitosan > FeSO4 > (C2H5)2NCS2Na. Two types of reagents (six reagents) were combined based on the target properties of different reagents and the stabilization efficiency was evaluated and analyzed. The results indicated that the composite reagents had higher stabilization efficiency: the efficiency of 3% FeSO4 + 5% CaO was 81.7%, 97.2% and 68.2% for As, Cd and Zn, respectively, and the efficiency of 3% CaO + 5% organic sulfur was 76.6%, 95.7% and 93.8% for these three metals, respectively. Speciation analysis was carried out in this study and the results suggested that it was the change of metals from the exchangeable state to the reduction (for inorganic reagent) or oxidation state (for organic reagent) that caused the soil stabilization and the degree of change determined the stabilization efficiency.

Joint kinematics and kinetics of overground accelerated running versus running on an accelerated treadmill

PubMed Central

Van Caekenberghe, Ine; Segers, Veerle; Aerts, Peter; Willems, Patrick; De Clercq, Dirk

2013-01-01

Literature shows that running on an accelerated motorized treadmill is mechanically different from accelerated running overground. Overground, the subject has to enlarge the net anterior–posterior force impulse proportional to acceleration in order to overcome linear whole body inertia, whereas on a treadmill, this force impulse remains zero, regardless of belt acceleration. Therefore, it can be expected that changes in kinematics and joint kinetics of the human body also are proportional to acceleration overground, whereas no changes according to belt acceleration are expected on a treadmill. This study documents kinematics and joint kinetics of accelerated running overground and running on an accelerated motorized treadmill belt for 10 young healthy subjects. When accelerating overground, ground reaction forces are characterized by less braking and more propulsion, generating a more forward-oriented ground reaction force vector and a more forwardly inclined body compared with steady-state running. This change in body orientation as such is partly responsible for the changed force direction. Besides this, more pronounced hip and knee flexion at initial contact, a larger hip extension velocity, smaller knee flexion velocity and smaller initial plantarflexion velocity are associated with less braking. A larger knee extension and plantarflexion velocity result in larger propulsion. Altogether, during stance, joint moments are not significantly influenced by acceleration overground. Therefore, we suggest that the overall behaviour of the musculoskeletal system (in terms of kinematics and joint moments) during acceleration at a certain speed remains essentially identical to steady-state running at the same speed, yet acting in a different orientation. However, because acceleration implies extra mechanical work to increase the running speed, muscular effort done (in terms of power output) must be larger. This is confirmed by larger joint power generation at the level

[Stability of physical state on compound hawthorn dropping pills].

PubMed

Zhang, Wei; Chen, Hong-Yan; Jiang, Jian-Lan

2008-11-01

To evaluate the stability of physical state with accelerate test and dropping in process before and after on compound hawthorn dropping pills. Scanning electron microscope, TG-DTA, FT-IR and XRD were used. The active components presented amorphous, tiny crystal and molecular state in dropping pills, and it had no obvious reaction between PEG 4000 and active components. With time prolonging, a little of active components changed from amorphous state to tiny crystal or molecular state. Solid dispersion improved the stability and dissolution of compound hawthorn dropping pills.

Centripetal Acceleration Reaction: An Effective and Robust Mechanism for Flapping Flight in Insects.

PubMed

Zhang, Chao; Hedrick, Tyson L; Mittal, Rajat

2015-01-01

Despite intense study by physicists and biologists, we do not fully understand the unsteady aerodynamics that relate insect wing morphology and kinematics to lift generation. Here, we formulate a force partitioning method (FPM) and implement it within a computational fluid dynamic model to provide an unambiguous and physically insightful division of aerodynamic force into components associated with wing kinematics, vorticity, and viscosity. Application of the FPM to hawkmoth and fruit fly flight shows that the leading-edge vortex is the dominant mechanism for lift generation for both these insects and contributes between 72-85% of the net lift. However, there is another, previously unidentified mechanism, the centripetal acceleration reaction, which generates up to 17% of the net lift. The centripetal acceleration reaction is similar to the classical inviscid added-mass in that it depends only on the kinematics (i.e. accelerations) of the body, but is different in that it requires the satisfaction of the no-slip condition, and a combination of tangential motion and rotation of the wing surface. Furthermore, the classical added-mass force is identically zero for cyclic motion but this is not true of the centripetal acceleration reaction. Furthermore, unlike the lift due to vorticity, centripetal acceleration reaction lift is insensitive to Reynolds number and to environmental flow perturbations, making it an important contributor to insect flight stability and miniaturization. This force mechanism also has broad implications for flow-induced deformation and vibration, underwater locomotion and flows involving bubbles and droplets.

Experimental, Theoretical and Computational Studies of Plasma-Based Concepts for Future High Energy Accelerators

DOE Office of Scientific and Technical Information (OSTI.GOV)

Joshi, Chan; Mori, W.

2013-10-21

This is the final report on the DOE grant number DE-FG02-92ER40727 titled, “Experimental, Theoretical and Computational Studies of Plasma-Based Concepts for Future High Energy Accelerators.” During this grant period the UCLA program on Advanced Plasma Based Accelerators, headed by Professor C. Joshi has made many key scientific advances and trained a generation of students, many of whom have stayed in this research field and even started research programs of their own. In this final report however, we will focus on the last three years of the grant and report on the scientific progress made in each of the four tasksmore » listed under this grant. Four tasks are focused on: Plasma Wakefield Accelerator Research at FACET, SLAC National Accelerator Laboratory, In House Research at UCLA’s Neptune and 20 TW Laser Laboratories, Laser-Wakefield Acceleration (LWFA) in Self Guided Regime: Experiments at the Callisto Laser at LLNL, and Theory and Simulations. Major scientific results have been obtained in each of the four tasks described in this report. These have led to publications in the prestigious scientific journals, graduation and continued training of high quality Ph.D. level students and have kept the U.S. at the forefront of plasma-based accelerators research field.« less

Multistage Coupling of Laser-Wakefield Accelerators with Curved Plasma Channels.

PubMed

Luo, J; Chen, M; Wu, W Y; Weng, S M; Sheng, Z M; Schroeder, C B; Jaroszynski, D A; Esarey, E; Leemans, W P; Mori, W B; Zhang, J

2018-04-13

Multistage coupling of laser-wakefield accelerators is essential to overcome laser energy depletion for high-energy applications such as TeV-level electron-positron colliders. Current staging schemes feed subsequent laser pulses into stages using plasma mirrors while controlling electron beam focusing with plasma lenses. Here a more compact and efficient scheme is proposed to realize the simultaneous coupling of the electron beam and the laser pulse into a second stage. A partly curved channel, integrating a straight acceleration stage with a curved transition segment, is used to guide a fresh laser pulse into a subsequent straight channel, while the electrons continue straight. This scheme benefits from a shorter coupling distance and continuous guiding of the electrons in plasma while suppressing transverse beam dispersion. Particle-in-cell simulations demonstrate that the electron beam from a previous stage can be efficiently injected into a subsequent stage for further acceleration while maintaining high capture efficiency, stability, and beam quality.

Multistage Coupling of Laser-Wakefield Accelerators with Curved Plasma Channels

NASA Astrophysics Data System (ADS)

Luo, J.; Chen, M.; Wu, W. Y.; Weng, S. M.; Sheng, Z. M.; Schroeder, C. B.; Jaroszynski, D. A.; Esarey, E.; Leemans, W. P.; Mori, W. B.; Zhang, J.

2018-04-01

Multistage coupling of laser-wakefield accelerators is essential to overcome laser energy depletion for high-energy applications such as TeV-level electron-positron colliders. Current staging schemes feed subsequent laser pulses into stages using plasma mirrors while controlling electron beam focusing with plasma lenses. Here a more compact and efficient scheme is proposed to realize the simultaneous coupling of the electron beam and the laser pulse into a second stage. A partly curved channel, integrating a straight acceleration stage with a curved transition segment, is used to guide a fresh laser pulse into a subsequent straight channel, while the electrons continue straight. This scheme benefits from a shorter coupling distance and continuous guiding of the electrons in plasma while suppressing transverse beam dispersion. Particle-in-cell simulations demonstrate that the electron beam from a previous stage can be efficiently injected into a subsequent stage for further acceleration while maintaining high capture efficiency, stability, and beam quality.

Efficiency Versus Instability in Plasma Accelerators

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lebedev, Valeri; Burov, Alexey; Nagaitsev, Sergei

2017-01-05

Plasma wake-field acceleration in a strongly nonlinear (a.k.a. the blowout) regime is one of the main candidates for future high-energy colliders. For this case, we derive a universal efficiency-instability relation, between the power efficiency and the key instability parameter of the witness bunch. We also show that in order to stabilize the witness bunch in a regime with high power efficiency, the bunch needs to have high energy spread, which is not presently compatible with collider-quality beam properties. It is unclear how such limitations could be overcome for high-luminosity linear colliders.

[Study on hydrothermal stability of the collagen].

PubMed

Wang, Yajuan; Chen, Hui; Shan, Zhihua

2009-02-01

The low hydrothermal stability of the raw collagen restricts its usage. To improve the hydrothermal stability of collagen, two kinds of materials with weak astringency were used by experts. The research proved that the synergistic effect was formed during the process. In this study, by using UV, FT-IR, 13CNMR spectra and elemental analysis on the salicylic acid and metal-salicylic complexes, we could get the structural formula of every compound. And then, the hide powder was treated with the compounds. At last, the treated hide powder was tested by DSC. It could be presumed that the Rigid Matrix formed between the collagen doses can increase the hydrothermal stability of raw collagen, The result indicated that salicylic-chrome with large stable constant was better than others in improving the heat resistance of raw collagen, and the denaturalization temperature of hide powder treated with salicylic-chrome was 146.7 degrees C. Salicylic-aluminum was in the second place, the relevant temperature being 145.7 degrees C.

First muon acceleration using a radio-frequency accelerator

NASA Astrophysics Data System (ADS)

Bae, S.; Choi, H.; Choi, S.; Fukao, Y.; Futatsukawa, K.; Hasegawa, K.; Iijima, T.; Iinuma, H.; Ishida, K.; Kawamura, N.; Kim, B.; Kitamura, R.; Ko, H. S.; Kondo, Y.; Li, S.; Mibe, T.; Miyake, Y.; Morishita, T.; Nakazawa, Y.; Otani, M.; Razuvaev, G. P.; Saito, N.; Shimomura, K.; Sue, Y.; Won, E.; Yamazaki, T.

2018-05-01

Muons have been accelerated by using a radio-frequency accelerator for the first time. Negative muonium atoms (Mu- ), which are bound states of positive muons (μ+) and two electrons, are generated from μ+'s through the electron capture process in an aluminum degrader. The generated Mu- 's are initially electrostatically accelerated and injected into a radio-frequency quadrupole linac (RFQ). In the RFQ, the Mu- 's are accelerated to 89 keV. The accelerated Mu- 's are identified by momentum measurement and time of flight. This compact muon linac opens the door to various muon accelerator applications including particle physics measurements and the construction of a transmission muon microscope.

Light-current-induced acceleration of degradation of methylammonium lead iodide perovskite solar cells

NASA Astrophysics Data System (ADS)

Xiang, Yuren; Zhang, Fan; He, Junjie; Lian, Jiarong; Zeng, Pengju; Song, Jun; Qu, Junle

2018-04-01

The photo-conversion efficiency of perovskite solar cells (PSCs) has been improved considerably in recent years, but the poor stability of PSCs still prevents their commercialization. In this report, we use the rate of the integrated short-circuit current change (Drate) to investigate the performance degradation kinetics and identify the degradation of PSCs that is accelerated by the light current. The value of Drate increases by an order of magnitude from about 0.02 to 0.35 mA cm-2·min-1 after light-IV testing. The accelerated degradation progress is proven to be dominated by the hydration process and the migration of the iodine ions of the light current. The migration of the iodine ions enhances the hydration process through a chain reaction, enabling the formation of fast diffusion channels for both H2O and O2, which induce the rapid decomposition of the perovskite film and increase the density of the trap state. The X-ray photoelectron spectroscopy measurement data also indicate that the super oxygen may be formed due to the PCBM damage caused by the migration iodine ions. An understanding of the degradation acceleration mechanism would provide an insight into the effect of ion migration on the stability of PSCs.

Enhanced switching stability in Ta2O5 resistive RAM by fluorine doping

NASA Astrophysics Data System (ADS)

Sedghi, N.; Li, H.; Brunell, I. F.; Dawson, K.; Guo, Y.; Potter, R. J.; Gibbon, J. T.; Dhanak, V. R.; Zhang, W. D.; Zhang, J. F.; Hall, S.; Robertson, J.; Chalker, P. R.

2017-08-01

The effect of fluorine doping on the switching stability of Ta2O5 resistive random access memory devices is investigated. It shows that the dopant serves to increase the memory window and improve the stability of the resistive states due to the neutralization of oxygen vacancies. The ability to alter the current in the low resistance state with set current compliance coupled with large memory window makes multilevel cell switching more favorable. The devices have set and reset voltages of <1 V with improved stability due to the fluorine doping. Density functional modeling shows that the incorporation of fluorine dopant atoms at the two-fold O vacancy site in the oxide network removes the defect state in the mid bandgap, lowering the overall density of defects capable of forming conductive filaments. This reduces the probability of forming alternative conducting paths and hence improves the current stability in the low resistance states. The doped devices exhibit more stable resistive states in both dc and pulsed set and reset cycles. The retention failure time is estimated to be a minimum of 2 years for F-doped devices measured by temperature accelerated and stress voltage accelerated retention failure methods.

PARTICLE ACCELERATOR

DOEpatents

Teng, L.C.

1960-01-19

ABS>A combination of two accelerators, a cyclotron and a ring-shaped accelerator which has a portion disposed tangentially to the cyclotron, is described. Means are provided to transfer particles from the cyclotron to the ring accelerator including a magnetic deflector within the cyclotron, a magnetic shield between the ring accelerator and the cyclotron, and a magnetic inflector within the ring accelerator.

Application of high hydrostatic pressure for increasing activity and stability of enzymes.

PubMed

Mozhaev, V V; Lange, R; Kudryashova, E V; Balny, C

1996-10-20

Elevated hydrostatic pressure has been used to increase catalytic activity and thermal stability of alpha-chymotrypsin (CT). For an anilide substrate, characterized by a negative value of the reaction activation volume (DeltaV( not equal)), an increase in pressure at 20 degrees C results in an exponential acceleration of the hydrolysis rate catalyzed by CT reaching a 6.5-fold increase in activity at 4700 atm (4.7 kbar). Due to a strong temperature dependence of DeltaV( not equal), the acceleration effect of high pressure becomes more pronounced at high temperatures. For example, at 50 degrees C, under a pressure of 3.6 kbar, CT shows activity which is more than 30 times higher than the activity at normal conditions (20 degrees C, 1 atm). At pressures of higher than 3.6 kbar, the enzymatic activity is decreased due to a pressure-induced denaturation.Elevated hydrostatic pressure is also efficient for increasing stability of CT against thermal denaturation. For example, at 55 degrees C, CT is almost instantaneously inactivated at atmospheric pressure, whereas under a pressure of 1.8 kbar CT retains its anilide-hydrolyzing activity during several dozen minutes. Additional stabilization can be achieved in the presence of glycerol, which is most effective for protection of CT at an intermediate concentration of 40% (v/v). There has been observed an additivity in stabilization effects of high pressure and glycerol: thermal inactivation of pressure-stabilized CT can be decelerated in a supplementary manner by addition of 40% (v/v) glycerol. The protection effect of glycerol on the catalytic activity and stability of CT becomes especially pronounced when both extreme factors of temperature and pressure reach critical values. For example, at approximately 55 degrees C and 4.7 kbar, enzymatic activity of CT in the presence of 40% (v/v) glycerol is severalfold higher than in aqueous buffer.The results of this study are discussed in terms of the hypotheses which explain the

Tritium target manufacturing for use in accelerators

NASA Astrophysics Data System (ADS)

Bach, P.; Monnin, C.; Van Rompay, M.; Ballanger, A.

2001-07-01

As a neutron tube manufacturer, SODERN is now in charge of manufacturing tritium targets for accelerators, in cooperation with CEA/DAM/DTMN in Valduc. Specific deuterium and tritium targets are manufactured on request, according to the requirements of the users, starting from titanium target on copper substrate, and going to more sophisticated devices. A wide range of possible uses is covered, including thin targets for neutron calibration, thick targets with controlled loading of deuterium and tritium, rotating targets for higher lifetimes, or large size rotating targets for accelerators used in boron neutron therapy. Activity of targets lies in the 1 to 1000 Curie, diameter of targets being up to 30 cm. Special targets are also considered, including surface layer targets for lowering tritium desorption under irradiation, or those made from different kinds of occluders such as titanium, zirconium, erbium, scandium, with different substrates. It is then possible to optimize either neutron output, or lifetime and stability, or thermal behavior.

Effects of general fatigue induced by incremental maximal exercise test on gait stability and variability of healthy young subjects.

PubMed

Vieira, Marcus Fraga; de Sá E Souza, Gustavo Souto; Lehnen, Georgia Cristina; Rodrigues, Fábio Barbosa; Andrade, Adriano O

2016-10-01

The purpose of this study was to determine whether general fatigue induced by incremental maximal exercise test (IMET) affects gait stability and variability in healthy subjects. Twenty-two young healthy male subjects walked in a treadmill at preferred walking speed for 4min prior (PreT) the test, which was followed by three series of 4min of walking with 4min of rest among them. Gait variability was assessed using walk ratio (WR), calculated as step length normalized by step frequency, root mean square (RMSratio) of trunk acceleration, standard deviation of medial-lateral trunk acceleration between strides (VARML), coefficient of variation of step frequency (SFCV), length (SLCV) and width (SWCV). Gait stability was assessed using margin of stability (MoS) and local dynamic stability (λs). VARML, SFCV, SLCV and SWCV increased after the test indicating an increase in gait variability. MoS decreased and λs increased after the test, indicating a decrease in gait stability. All variables showed a trend to return to PreT values, but the 20-min post-test interval appears not to be enough for a complete recovery. The results showed that general fatigue induced by IMET alters negatively the gait, and an interval of at least 20min should be considered for injury prevention in tasks with similar demands. Copyright © 2016 Elsevier Ltd. All rights reserved.

Accelerated aging characteristics of three yttria-stabilized tetragonal zirconia polycrystalline dental materials.

PubMed

Flinn, Brian D; deGroot, Dirk A; Mancl, Lloyd A; Raigrodski, Ariel J

2012-10-01

Concerns have been expressed about the effect of aging on the mechanical properties of zirconia. The purpose of this study was to assess the accelerated aging characteristics of 3 commercially available yttria-stabilized tetragonal zirconia polycrystalline (Y-TZP) materials by exposing specimens to hydrothermal treatments at 134°C, 0.2 MPa and 180°C, 1.0 MPa in steam. Thin bars of Y-TZP from 3 manufacturers, Lava, Zirkonzahn, and Zirprime, n=30 for each brand (22 × 3 × 0.2 mm), were cut and ground from blocks and sintered according to the manufacturer's specifications. Control specimens (n=10) for each brand were evaluated in the as-received condition. Experimental specimens were artificially aged at standard autoclave sterilization conditions,134°C at 0.2 MPa (n=5 per group at 50, 100, 150, and 200 hours) and standard industrial ceramic aging conditions, 180°C at 1.0 MPa (n=5 per group at 8, 16, 24, 28, and 48 hours). Tetragonal to monoclinic transformation was measured by using X-ray diffraction (XRD) for all groups. Flexural strength was measured in 4-point bending (ASTM1161-B) for all groups. Fracture surfaces were examined by scanning electron microscopy (SEM). Data were analyzed as a function of aging time. The statistical comparisons were based on the log value and 2-way ANOVA with heteroscedasticity-consistent standard errors used to compare mean strength among conditions (α=.05). After 200 hours at 134°C and 0.2 MPa, flexural strength (SD) decreased significantly from 1156 (87.6) MPa to 829.5 (71) MPa for Lava; 1406 (243) MPa to 882.7 (91) MPa for Zirkonzahn; and 1126 (92.4) MPa to 976 (36.4) MPa for Zirprime with P<.001 for all 3 comparisons. After 200 hours at 134°C and 0.2 MPa, some tetragonal crystals transformed to the monoclinic phase. The relative XRD peak intensity of the monoclinic to tetragonal crystal phases increased from 0.07 to 1.82 for Lava, from 0.06 to 2.43 for Zirkonzahn, and from 0.05 to 0.53 for Zirprime. After 28 hours at 180�

Parkin absence accelerates microtubule aging in dopaminergic neurons.

PubMed

Cartelli, Daniele; Amadeo, Alida; Calogero, Alessandra Maria; Casagrande, Francesca Vittoria Marialuisa; De Gregorio, Carmelita; Gioria, Mariarosa; Kuzumaki, Naoko; Costa, Ilaria; Sassone, Jenny; Ciammola, Andrea; Hattori, Nobutaka; Okano, Hideyuki; Goldwurm, Stefano; Roybon, Laurent; Pezzoli, Gianni; Cappelletti, Graziella

2018-01-01

Loss-of-function caused by mutations in the parkin gene (PARK2) lead to early-onset familial Parkinson's disease. Recently, mechanistic studies proved the ability of parkin in regulating mitochondria homeostasis and microtubule (MT) stability. Looking at these systems during aging of PARK2 knockout mice, we found that loss of parkin induced an accelerated (over)acetylation of MT system both in dopaminergic neuron cell bodies and fibers, localized in the substantia nigra and corpus striatum, respectively. Interestingly, in PARK2 knockout mice, changes of MT stability preceded the alteration of mitochondria transport. Moreover, in-cell experiments confirmed that loss of parkin affects mitochondria mobility and showed that this defect depends on MT system as it is rescued by paclitaxel, a well-known MT-targeted agent. Furthermore, both in PC12 neuronal cells and in patients' induced pluripotent stem cell-derived midbrain neurons, we observed that parkin deficiencies cause the fragmentation of stable MTs. Therefore, we suggest that parkin acts as a regulator of MT system during neuronal aging, and we endorse the hypothesis that MT dysfunction may be crucial in the pathogenesis of Parkinson's disease. Copyright © 2017 Elsevier Inc. All rights reserved.

Exploration of multi-fold symmetry element-loaded superconducting radio frequency structure for reliable acceleration of low- & medium-beta ion species

DOE Office of Scientific and Technical Information (OSTI.GOV)

Huang, Shichun; Geng, Rongli

2015-09-01

Reliable acceleration of low- to medium-beta proton or heavy ion species is needed for future high-current superconducting radio frequency (SRF) accelerators. Due to the high-Q nature of an SRF resonator, it is sensitive to many factors such as electron loading (from either the accelerated beam or from parasitic field emitted electrons), mechanical vibration, and liquid helium bath pressure fluctuation etc. To increase the stability against those factors, a mechanically strong and stable RF structure is desirable. Guided by this consideration, multi-fold symmetry element-loaded SRF structures (MFSEL), cylindrical tanks with multiple (n>=3) rod-shaped radial elements, are being explored. The top goalmore » of its optimization is to improve mechanical stability. A natural consequence of this structure is a lowered ratio of the peak surface electromagnetic field to the acceleration gradient as compared to the traditional spoke cavity. A disadvantage of this new structure is an increased size for a fixed resonant frequency and optimal beta. This paper describes the optimization of the electro-magnetic (EM) design and preliminary mechanical analysis for such structures.« less

Imidazolium Cations with Exceptional Alkaline Stability: A Systematic Study of Structure–Stability Relationships

DOE PAGES

Hugar, Kristina M.; Kostalik, IV, Henry A.; Coates, Geoffrey W.

2015-06-11

Highly base-stable cationic moieties are a critical component of anion exchange membranes (AEMs) in alkaline fuel cells (AFCs); however, the commonly employed organic cations have limited alkaline stability. To address this problem, we synthesized and characterized the stability of a series of imidazolium cations in 1, 2, or 5 M KOH/CD 3OH at 80 °C, systematically evaluating the impact of substitution on chemical stability. The substituent identity at each position of the imidazolium ring has a dramatic effect on the overall cation stability. In conclusion, we report imidazolium cations that have the highest alkaline stabilities reported to date, >99% cationmore » remaining after 30 days in 5 M KOH/CD 3OH at 80 °C.« less

Design of an unified chassis controller for rollover prevention, manoeuvrability and lateral stability

NASA Astrophysics Data System (ADS)

Yoon, Jangyeol; Yim, Seongjin; Cho, Wanki; Koo, Bongyeong; Yi, Kyongsu

2010-11-01

This paper describes a unified chassis control (UCC) strategy to prevent vehicle rollover and improve both manoeuvrability and lateral stability. Since previous researches on rollover prevention are only focused on the reduction of lateral acceleration, the manoeuvrability and lateral stability cannot be guaranteed. For this reason, it is necessary to design a UCC controller to prevent rollover and improve lateral stability by integrating electronic stability control, active front steering and continuous damping control. This integration is performed through switching among several control modes and a simulation is performed to validate the proposed method. Simulation results indicate that a significant improvement in rollover prevention, manoeuvrability and lateral stability can be expected from the proposed UCC system.

Improving the Stability and the Pharmaceutical Properties of Norfloxacin Form C Through Binary Complexes with β-Cyclodextrin.

PubMed

Garnero, Claudia; Chattah, Ana Karina; Aloisio, Carolina; Fabietti, Luis; Longhi, Marcela

2018-05-10

Norfloxacin, an antibiotic that exists in different solid forms, has very unfavorable properties in terms of solubility and stability. Binary complexes of norfloxacin, in the solid form C, and β-cyclodextrin were procured by the kneading method and physical mixture. Their effect on the solubility, the dissolution rate, and the chemical and physical stability of norfloxacin was evaluated. To perform stability studies, the solid samples were stored under accelerated storage conditions, for a period of 6 months. Physical stability was monitored through powder X-ray diffraction, high-resolution 13 C solid-state nuclear magnetic resonance, and scanning electron microscopy. The results showed evidence that the kneaded complex increased and modulated the dissolution rate of norfloxacin C. Furthermore, it was demonstrated that the photochemical stability was increased in the complex, without affecting its physical stability. The results point to the conclusion that the new kneading complex of norfloxacin constitutes an alternative tool to formulate a potential oral drug delivery system with improve oral bioavailability.

The study of two-dimensional oscillations using a smartphone acceleration sensor: example of Lissajous curves

NASA Astrophysics Data System (ADS)

Tuset-Sanchis, Luis; Castro-Palacio, Juan C.; Gómez-Tejedor, José A.; Manjón, Francisco J.; Monsoriu, Juan A.

2015-08-01

A smartphone acceleration sensor is used to study two-dimensional harmonic oscillations. The data recorded by the free android application, Accelerometer Toy, is used to determine the periods of oscillation by graphical analysis. Different patterns of the Lissajous curves resulting from the superposition of harmonic motions are illustrated for three experiments. This work introduces an example of how two-dimensional oscillations can be easily studied with a smartphone acceleration sensor.

The methodology study of time accelerated irradiation of elastomers

NASA Astrophysics Data System (ADS)

Ito, Masayuki

2005-07-01

The article studied the methods how to shorten the irradiation time by increasing dose rate without changing the relationship between dose versus properties of degraded samples. The samples used were nine kinds of EPDM which have different compounding formula. The different dose of Co-γ ray was exposed to the samples. The maximum dose was 2 MGy. The reference condition to be compared with two short time test conditions is irradiation of 0.33 kGy/h at room temperature. Two methods shown below were studied as the time-accelerate irradiation conditions.

Amorphous Sulfadoxine: A Physical Stability and Crystallization Kinetics Study.

PubMed

Aucamp, Marique; Milne, Marnus; Liebenberg, Wilna

2016-10-01

Poor aqueous solubility of drugs and the improvement thereof has always been a challenge for the pharmaceutical industry. With this, one of the focuses of the pharmaceutical research scientist involves investigating possible metastable forms of a given drug to be incorporated into solid dosage forms. The rationale being, the improved solubility offered by the metastable solid-state forms of drugs. Solubility remains a major challenge for formulation scientists, especially with antimicrobial agents where the emergence of resistance is directly dependent on the concentration and duration of the parasite exposed to the drug. Sulfadoxine-pyrimethamine combination therapies are still the recommended treatments for uncomplicated Plasmodium falciparum malaria. The aim of this study was to prepare an amorphous form of sulfadoxine and to investigate the stability and recrystallization behavior thereof. The amorphous form was prepared by the well-known quench cooling of the melt. The physico-chemical properties and stability of amorphous sulfadoxine were studied using hot-stage microscopy (HSM), scanning electron microscopy (SEM), x-ray powder diffractometry (XRPD), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), as well as microcalorimetry. The recrystallization kinetics were studied isothermally by applying the Johnson-Mehl-Avrami model and non-isothermally by applying the Kissinger model. The physical stabilization of the amorphous form was investigated using physical mixtures of amorphous sulfadoxine with polyvinylpyrrolidone-25 (PVP-25). It was proved that sulfadoxine is a good glass former with relative high physical stability; however, water acts as a strong plasticizer for amorphous sulfadoxine, detrimentally affecting the stability during exposure to high moisture conditions.

The postural stability of children with foetal alcohol spectrum disorders during one-leg stance: A feasibility study

PubMed Central

2018-01-01

Background Postural control may be impaired in children with foetal alcohol spectrum disorders (FASD). The study assessed the protocol feasibility in terms of (1) recruiting children with FASD in a rural, small town; (2) using the measurement instruments in a real-life setting; (3) the one-leg standing (OLS) task and (4) presenting preliminary results on postural stability of children with and without FASD. Methods Nine-year-old children diagnosed with and without FASD were invited to participate. Twenty-eight children performed OLS. Feasibility outcomes included recruitment, measurement instrument use and task instruction. Postural stability outcomes included standing duration, centre of pressure (COP) and body segment acceleration. Results Participants recruitment was feasible in terms of the (1) ability to sample a reasonable participant number in a rural town setting and the capacity to increase the sample size if more schools are included in the sampling frame and (2) use of assent and consent forms that were appropriate for this population. The measurement instruments were user-friendly, cost-effective and time-efficient. Instructions for the task require amendment to address foot placement of the non-weight–bearing leg. There was a significant difference between cases and controls on mean COP velocity (p = 0.001) and the pelvis segment acceleration in the mediolateral direction (p = 0.01) and the anteroposterior direction (p = 0.027). The control children took longer to achieve postural control. The girls demonstrated a significant difference for the COP anteroposterior displacement (p = 0.008) and velocity (p = 0.049). Conclusions The recruitment of children with and without FASD in a rural, small town and the administration of measurement instruments in a real-life, school-based setting was feasible. However, the verbal instructions for the task require revision. The male control group took longer to achieve postural control because the task was

Study on the stability control strategy of Triphala solution based on the balance of physical stability and chemical stabilities.

PubMed

Huang, Hao-Zhou; Zhao, Sheng-Yu; Ke, Xiu-Mei; Lin, Jun-Zhi; Huang, Shu-Sen; Xu, Run-Chun; Ma, Hong-Yan; Zhang, Yi; Han, Li; Zhang, Ding-Kun

2018-06-04

Triphala is a well-known prescription in Indian Ayurveda and TCM medicine for its great effect on gingivitis and hyperlipidemia. However, its solution is unstable for the containing of excessive polyphenol, leading to the production of sediment in the short term and the decrease of efficacy. Based on the analysis of sediment formation, a novel control strategy is proposed. To conduct the analysis, the sediment formation was recorded for a consecutive five days. The changes in the composition of the supernatant and the sediment were studied by the HPLC profile analysis. The main components of the sediment were identified as corilagin, ellagic acid and gallic acid, and the amount of ellagic acid sediment increased with the storage time. Then, with a series of pH status adjustments of the Triphala solution, the physical and chemical stabilities were acquired by Turbiscan and HPLC respectively. The results showed that as the pH value increased, so did the physical stability, but the particle size and TSI of the association decreased. While the fingerprint of chemical profile similarity decreased, so did the chemical stability. Combining physical and chemical stability parameters, an equilibrium point was found out. When the pH value was adjusted to 5.0, both the physical and chemical stabilities were better: the verification test showed that the sedimentation inhibition rates on the 3rd, 5th,10th and15th days were 41%, 55%, 41%, and 23%, respectively. This manuscript provided a new control strategy that will pique pharmaceutical and food development engineers' interest and trigger research ideas controlling the quality of decoction. Copyright © 2018 Elsevier B.V. All rights reserved.

Accelerator Science: Circular vs. Linear

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lincoln, Don

Particle accelerator are scientific instruments that allow scientists to collide particles together at incredible energies to study the secrets of the universe. However, there are many manners in which particle accelerators can be constructed. In this video, Fermilab’s Dr. Don Lincoln explains the pros and cons of circular and linear accelerators.

Operation of polycarbonate projectiles in the ram accelerator

NASA Astrophysics Data System (ADS)

Elder, Timothy

The ram accelerator is a hypervelocity launcher with direct space launch applications in which a sub-caliber projectile, analogous to the center-body of a ramjet engine, flies through fuel and oxidizer that have been premixed in a tube. Shock interactions in the tube ignite the propellant upon entrance of the projectile and the combustion travels with it, creating thrust on the projectile by stabilizing a high pressure region of gas behind it. Conventional ram accelerator projectiles consist of aluminum, magnesium, or titanium nosecones and bodies. An experimental program has been undertaken to determine the performance of polycarbonate projectiles in ram accelerator operation. Experimentation using polycarbonate projectiles has been divided into two series: determining the lower limit for starting velocity (i.e., less than 1100 m/s) and investigating the upper velocity limit. To investigate the influence of body length and starting velocity, a newly developed "combustion gun" was used to launch projectiles to their initial velocities. The combustion gun uses 3-6 m of ram accelerator test section as a breech and 4-6 m of the ram accelerator test section as a launch tube. A fuel-oxidizer mix is combusted in the breech using a spark plug or electric match and bursts a diaphragm, accelerating the ram projectile to its entrance velocity. The combustion gun can be operated at modest fill pressures (20 bar) but can only launch to relatively low velocities (approximately 1000 m/s) without destroying the projectile and obturator upon launch. Projectiles were successfully started at entrance velocities as low as 810 m/s and projectile body lengths as long as 91 mm were used. The tests investigating the upper Mach number limits of polycarbonate projectiles used the conventional single-stage light-gas gun because of its ability to reach higher velocities with a lower acceleration launch. It was determined that polycarbonate projectiles have an upper velocity limit in the

Lean Stability augmentation study

NASA Technical Reports Server (NTRS)

Mcvey, J. B.; Kennedy, J. B.

1979-01-01

An analytical and experimental program was conducted to investigate techniques and develop technology for improving the lean combustion limits of premixing, prevaporizing combustors applicable to gas turbine engine main burners. Three concepts for improving lean stability limits were selected for experimental evaluation among twelve approaches considered. Concepts were selected on the basis of the potential for improving stability limits and achieving emission goals, the technological risks associated with development of practical burners employing the concepts, and the penalties to airline direct operating costs resulting from decreased combustor performance, increased engine cost, increased maintenance cost and increased engine weight associated with implementation of the concepts. Tests of flameholders embodying the selected concepts were conducted.

Paper Microzone Plates as Analytical Tools for Studying Enzyme Stability: A Case Study on the Stabilization of Horseradish Peroxidase Using Trehalose and SU-8 Epoxy Novolac Resin.

PubMed

Ganaja, Kirsten A; Chaplan, Cory A; Zhang, Jingyi; Martinez, Nathaniel W; Martinez, Andres W

2017-05-16

Paper microzone plates in combination with a noncontact liquid handling robot were demonstrated as tools for studying the stability of enzymes stored on paper. The effect of trehalose and SU-8 epoxy novolac resin (SU-8) on the stability of horseradish peroxidase (HRP) was studied in both a short-term experiment, where the activity of various concentrations of HRP dried on paper were measured after 1 h, and a long-term experiment, where the activity of a single concentration of HRP dried and stored on paper was monitored for 61 days. SU-8 was found to stabilize HRP up to 35 times more than trehalose in the short-term experiment for comparable concentrations of the two reagents, and a 1% SU-8 solution was found to stabilize HRP approximately 2 times more than a 34% trehalose solution in both short- and long-term experiments. The results suggest that SU-8 is a promising candidate for use as an enzyme-stabilizing reagent for paper-based diagnostic devices and that the short-term experiment could be used to quickly evaluate the capacity of various reagents for stabilizing enzymes to identify and characterize new enzyme-stabilizing reagents.

Stabilization of Landslides for the Improvement of Aquatic Habitat

Treesearch

Michael J. Furniss

1989-01-01

Chronic surface and mass erosion from recent landslides often prevents the recovery of productive stream habitats following initial mass failure events. Low-cost methods that can accelerate recovery and stabilization processes have been employed on numerous failed slopes in the Six Rivers National Forest in the northwest corner of California, with notable success. Two...

Accelerator Science: Circular vs. Linear

ScienceCinema

Lincoln, Don

2018-06-12

Particle accelerator are scientific instruments that allow scientists to collide particles together at incredible energies to study the secrets of the universe. However, there are many manners in which particle accelerators can be constructed. In this video, Fermilab’s Dr. Don Lincoln explains the pros and cons of circular and linear accelerators.

Design Considerations of a Novel Two-Beam Accelerator

NASA Astrophysics Data System (ADS)

Luginsland, John William

This thesis reports the design study of a new type of charged particle accelerator called the Twobetron. The accelerator consists of two beams of electrons traveling through a series of pillbox cavities. The power of a high current annular beam excites an electromagnetic mode in the cavities, which, in turn, drives a low current on-axis pencil beam to high energy. We focus on the design considerations that would make use of existing pulsed power systems, for a proof-of-principle experiment. Potential applications of this new device include radiotherapy, materials processing, and high energy accelerators. The first phase of the research involves analytic description of the accelerating process. This reveals the problem of phase slippage. Derbenev's proposed cure of beam radius modulation is analyzed. Further studies include the effect of initial phase and secondary beam loading. Scaling laws to characterize the Twobetron's performance are derived. Computer simulation is performed to produce a self-consistent analysis of the dynamics of the space charge and its interaction with the accelerator structure. Particle -in-cell simulations answer several questions concerning beam stability, cavity modes, and the nature of the structure. Specifically, current modulation on the primary beam is preserved in the simulations. However, these simulations also revealed that mode competition and significant cavity coupling are serious issues that need to be addressed. Also considered is non-axisymmetric instability on the driver beam of the Twobetron, in particular, the beam breakup instability (BBU), which is known to pose a serious threat to linear accelerators in general. We extend the classical analysis of BBU to annular beams. The effect of higher order non-axisymmetric modes is also examined. It is shown that annular beams are more stable than pencil beams to BBU in general. Our analysis also reveals that the rf magnetic field is more important than the rf electric field in

Determination of Polymer Additives-Antioxidants, Ultraviolet Stabilizers, Plasticizers and Photoinitiators in Plastic Food Package by Accelerated Solvent Extraction Coupled with High-Performance Liquid Chromatography.

PubMed

Li, Bo; Wang, Zhi-Wei; Lin, Qin-Bao; Hu, Chang-Ying; Su, Qi-Zhi; Wu, Yu-Mei

2015-07-01

An analytical method for the quantitative determination of 4 antioxidants, 9 ultraviolet (UV) stabilizers, 12 phthalate plasticizers and 2 photoinitiators in plastic food package using accelerated solvent extraction (ASE) coupled with high-performance liquid chromatography-photodiode array detector (HPLC-PDA) has been developed. Parameters affecting the efficiency in the process such as extraction and chromatographic conditions were studied in order to determine operating conditions. The analytical method of ASE-HPLC showed good linearity with good correlation coefficients (R ≥ 0.9833). The limits of detection and quantification were between 0.03 and 0.30 µg mL(-1) and between 0.10 and 1.00 µg mL(-1) for 27 analytes. Average spiked recoveries for most analytes in samples were >70.4% at 10, 20 and 40 µg g(-1) spiked levels, except UV-9 and Irganox 1010 (58.6 and 64.0% spiked at 10 µg g(-1), respectively), the relative standard deviations were in the range from 0.4 to 15.4%. The methodology has been proposed for the analysis of 27 polymer additives in plastic food package. © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Trunk Acceleration for Neuroprosthetic Control of Standing – a Pilot Study

PubMed Central

Audu, Musa L.; Kirsch, Robert F.; Triolo, Ronald J.

2013-01-01

This pilot study investigated the potential of using trunk acceleration feedback control of center of pressure (COP) against postural disturbances with a standing neuroprosthesis following paralysis. Artificial neural networks (ANNs) were trained to use three-dimensional trunk acceleration as input to predict changes in COP for able-bodied subjects undergoing perturbations during bipedal stance. Correlation coefficients between ANN predictions and actual COP ranged from 0.67 to 0.77. An ANN trained across all subject-normalized data was used to drive feedback control of ankle muscle excitation levels for a computer model representing a standing neuroprosthesis user. Feedback control reduced average upper-body loading during perturbation onset and recovery by 42% and peak loading by 29% compared to optimal, constant excitation. PMID:21975251

Cervical stability training with and without core stability training for patients with cervical disc herniation: A randomized, single-blind study.

PubMed

Buyukturan, B; Guclu-Gunduz, A; Buyukturan, O; Dadali, Y; Bilgin, S; Kurt, E E

2017-11-01

This study aims at evaluating and comparing the effects of cervical stability training to combined cervical and core stability training in patients with neck pain and cervical disc herniation. Fifty patients with neck pain and cervical disc herniation were included in the study, randomly divided into two groups as cervical stability and cervical-core stability. Training was applied three times a week in three phases, and lasted for a total duration of 8 weeks. Pain, activation and static endurance of deep cervical flexor muscles, static endurance of neck muscles, cross-sectional diameter of M. Longus Colli, static endurance of trunk muscles, disability and kinesiophobia were assessed. Pain, activation and static endurance of deep cervical flexors, static endurance of neck muscles, cross-sectional diameter of M. Longus Colli, static endurance of trunk muscles, disability and kinesiophobia improved in both groups following the training sessions (p < 0.05). Comparison of the effectiveness of these two training methods revealed that the cervical stability group produced a greater increase in the right transverse diameter of M. Longus Colli (p < 0.05). However, static endurance of trunk muscles and kinesiophobia displayed better improvement in the cervical-core stability group (p < 0.05). Cervical stability training provided benefit to patients with cervical disc herniation. The addition of core stability training did not provide any additional significant benefit. Further research is required to investigate the efficacy of combining other techniques with cervical stability training in patients with cervical disc herniation. Both cervical stability training and its combination with core stability training were significantly and similarly effective on neck pain and neck muscle endurance in patients with cervical disc herniation. © 2017 European Pain Federation - EFIC®.

Coupling and decoupling of the accelerating units for pulsed synchronous linear accelerator

NASA Astrophysics Data System (ADS)

Shen, Yi; Liu, Yi; Ye, Mao; Zhang, Huang; Wang, Wei; Xia, Liansheng; Wang, Zhiwen; Yang, Chao; Shi, Jinshui; Zhang, Linwen; Deng, Jianjun

2017-12-01

A pulsed synchronous linear accelerator (PSLA), based on the solid-state pulse forming line, photoconductive semiconductor switch, and high gradient insulator technologies, is a novel linear accelerator. During the prototype PSLA commissioning, the energy gain of proton beams was found to be much lower than expected. In this paper, the degradation of the energy gain is explained by the circuit and cavity coupling effect of the accelerating units. The coupling effects of accelerating units are studied, and the circuit topologies of these two kinds of coupling effects are presented. Two methods utilizing inductance and membrane isolations, respectively, are proposed to reduce the circuit coupling effects. The effectiveness of the membrane isolation method is also supported by simulations. The decoupling efficiency of the metal drift tube is also researched. We carried out the experiments on circuit decoupling of the multiple accelerating cavity. The result shows that both circuit decoupling methods could increase the normalized voltage.

Covariant Uniform Acceleration

NASA Astrophysics Data System (ADS)

Friedman, Yaakov; Scarr, Tzvi

2013-04-01

We derive a 4D covariant Relativistic Dynamics Equation. This equation canonically extends the 3D relativistic dynamics equation , where F is the 3D force and p = m0γv is the 3D relativistic momentum. The standard 4D equation is only partially covariant. To achieve full Lorentz covariance, we replace the four-force F by a rank 2 antisymmetric tensor acting on the four-velocity. By taking this tensor to be constant, we obtain a covariant definition of uniformly accelerated motion. This solves a problem of Einstein and Planck. We compute explicit solutions for uniformly accelerated motion. The solutions are divided into four Lorentz-invariant types: null, linear, rotational, and general. For null acceleration, the worldline is cubic in the time. Linear acceleration covariantly extends 1D hyperbolic motion, while rotational acceleration covariantly extends pure rotational motion. We use Generalized Fermi-Walker transport to construct a uniformly accelerated family of inertial frames which are instantaneously comoving to a uniformly accelerated observer. We explain the connection between our approach and that of Mashhoon. We show that our solutions of uniformly accelerated motion have constant acceleration in the comoving frame. Assuming the Weak Hypothesis of Locality, we obtain local spacetime transformations from a uniformly accelerated frame K' to an inertial frame K. The spacetime transformations between two uniformly accelerated frames with the same acceleration are Lorentz. We compute the metric at an arbitrary point of a uniformly accelerated frame. We obtain velocity and acceleration transformations from a uniformly accelerated system K' to an inertial frame K. We introduce the 4D velocity, an adaptation of Horwitz and Piron s notion of "off-shell." We derive the general formula for the time dilation between accelerated clocks. We obtain a formula for the angular velocity of a uniformly accelerated object. Every rest point of K' is uniformly accelerated, and

The Longitudinal Stability of Flying Boats as Determined by Tests of Models in the NACA Tank II : Effect of Variations in Form of Hull on Longitudinal Stability

NASA Technical Reports Server (NTRS)

Olson, Roland E.; Truscott, Starr

1942-01-01

Data taken from tests at constant speed to establish trim limits of stability, tests at accelerated speeds to determine stable limits of center of gravity shift, and tests at decelerated speeds to obtain landing characteristics of several model hull forms were used to establish hull design effect on longitudinal stability of porpoising. Results show a reduction of dead rise angle as being the only investigated factor reducing low trim limit. Various methods of reducing afterbody interference increased upper trim limit

Analyzing radial acceleration with a smartphone acceleration sensor

NASA Astrophysics Data System (ADS)

Vogt, Patrik; Kuhn, Jochen

2013-03-01

This paper continues the sequence of experiments using the acceleration sensor of smartphones (for description of the function and the use of the acceleration sensor, see Ref. 1) within this column, in this case for analyzing the radial acceleration.

Centripetal Acceleration Reaction: An Effective and Robust Mechanism for Flapping Flight in Insects

PubMed Central

Zhang, Chao; Hedrick, Tyson L.; Mittal, Rajat

2015-01-01

Despite intense study by physicists and biologists, we do not fully understand the unsteady aerodynamics that relate insect wing morphology and kinematics to lift generation. Here, we formulate a force partitioning method (FPM) and implement it within a computational fluid dynamic model to provide an unambiguous and physically insightful division of aerodynamic force into components associated with wing kinematics, vorticity, and viscosity. Application of the FPM to hawkmoth and fruit fly flight shows that the leading-edge vortex is the dominant mechanism for lift generation for both these insects and contributes between 72–85% of the net lift. However, there is another, previously unidentified mechanism, the centripetal acceleration reaction, which generates up to 17% of the net lift. The centripetal acceleration reaction is similar to the classical inviscid added-mass in that it depends only on the kinematics (i.e. accelerations) of the body, but is different in that it requires the satisfaction of the no-slip condition, and a combination of tangential motion and rotation of the wing surface. Furthermore, the classical added-mass force is identically zero for cyclic motion but this is not true of the centripetal acceleration reaction. Furthermore, unlike the lift due to vorticity, centripetal acceleration reaction lift is insensitive to Reynolds number and to environmental flow perturbations, making it an important contributor to insect flight stability and miniaturization. This force mechanism also has broad implications for flow-induced deformation and vibration, underwater locomotion and flows involving bubbles and droplets. PMID:26252016

Cilazapril stability in the presence of hydrochlorothiazide in model mixtures and fixed dose combination.

PubMed

Paszun, Sylwia K; Stanisz, Beata J; Gradowska, Agnieszka

2013-01-01

The presented study aimed at the evaluation of hydrochlorothiazide influence on cilazapril stability in model mixture and fixed dose tablet formulation. The degradation of cilazapril in the presence of hydrochlorothiazide took place according to autocatalytic reaction kinetic mechanism, described mathematically by Prout-Tompkins equation. Hydrochlorothiazide coexistence with cilazapril in model mixture and fixed dose tablet without blister package accelerated cilazapril degradation in comparison with degradation of cilazapril substance. Values of reaction induction time shortened, while those of observed reaction rate constant increased. Increasing values of relative humidity and temperature have negative impact on cilazapril stability. Determined semi-logarithmic relationships: In k = f(RH) and Arrhenius ln k = f(1/T) are linear and are cilazapril stability predictive. The blister (OPA/Alu/PVC//Alu) package of fixed dose tablets, constitutes absolute moisture protection and prevent cilazapril--hydrochlorothiazide interaction occurrence.

Stability and perturbations of countable Markov maps

NASA Astrophysics Data System (ADS)

Jordan, Thomas; Munday, Sara; Sahlsten, Tuomas

2018-04-01

Let T and , , be countable Markov maps such that the branches of converge pointwise to the branches of T, as . We study the stability of various quantities measuring the singularity (dimension, Hölder exponent etc) of the topological conjugacy between and T when . This is a well-understood problem for maps with finitely-many branches, and the quantities are stable for small ɛ, that is, they converge to their expected values if . For the infinite branch case their stability might be expected to fail, but we prove that even in the infinite branch case the quantity is stable under some natural regularity assumptions on and T (under which, for instance, the Hölder exponent of fails to be stable). Our assumptions apply for example in the case of Gauss map, various Lüroth maps and accelerated Manneville-Pomeau maps when varying the parameter α. For the proof we introduce a mass transportation method from the cusp that allows us to exploit thermodynamical ideas from the finite branch case. Dedicated to the memory of Bernd O Stratmann

Overcoming bioanalytical challenges in an Onglyza(®) intravenous [(14)C]microdose absolute bioavailability study with accelerator MS.

PubMed

Xu, Xiaohui Sophia; Dueker, Stephen R; Christopher, Lisa J; Lohstroh, Pete N; Keung, Chi Fung Anther; Cao, Kai Kevin; Bonacorsi, Samuel J; Cojocaru, Laura; Shen, Jim X; Humphreys, W Griffith; Stouffer, Bruce; Arnold, Mark E

2012-08-01

An absolute bioavailability study that utilized an intravenous [(14)C]microdose was conducted for saxagliptin (Onglyza(®)), a marketed drug product for the treatment of Type 2 diabetes mellitus. Concentrations of [(14)C]saxagliptin were determined by accelerator MS (AMS) after protein precipitation, chromatographic separation by UPLC and analyte fraction collection. A series of investigative experiments were conducted to maximize the release of the drug from high-affinity receptors and nonspecific adsorption, and to determine a suitable quantitation range. A technique-appropriate validation demonstrated the accuracy, precision, specificity, stability and recovery of the AMS methodology across the concentration range of 0.025 to 15.0 dpm/ml (disintegration per minute per milliliter), the equivalent of 1.91-1144 pg/ml. Based on the study sample analysis, the mean absolute bioavailability of saxagliptin was 50% in the eight subjects with a CV of 6.6%. Incurred sample reanalysis data fell well within acceptable limits. This study demonstrated that the optimized sample pretreatment and chromatographic separation procedures were critical for the successful implementation of an UPLC plus AMS method for [(14)C]saxagliptin. The use of multiple-point standards are useful, particularly during method development and validation, to evaluate and correct for concentration-dependent recovery, if observed, and to monitor and control process loss and operational variations.

Future HEP Accelerators: The US Perspective

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bhat, Pushpalatha; Shiltsev, Vladimir

2015-11-02

Accelerator technology has advanced tremendously since the introduction of accelerators in the 1930s, and particle accelerators have become indispensable instruments in high energy physics (HEP) research to probe Nature at smaller and smaller distances. At present, accelerator facilities can be classified into Energy Frontier colliders that enable direct discoveries and studies of high mass scale particles and Intensity Frontier accelerators for exploration of extremely rare processes, usually at relatively low energies. The near term strategies of the global energy frontier particle physics community are centered on fully exploiting the physics potential of the Large Hadron Collider (LHC) at CERN throughmore » its high-luminosity upgrade (HL-LHC), while the intensity frontier HEP research is focused on studies of neutrinos at the MW-scale beam power accelerator facilities, such as Fermilab Main Injector with the planned PIP-II SRF linac project. A number of next generation accelerator facilities have been proposed and are currently under consideration for the medium- and long-term future programs of accelerator-based HEP research. In this paper, we briefly review the post-LHC energy frontier options, both for lepton and hadron colliders in various regions of the world, as well as possible future intensity frontier accelerator facilities.« less

Report on accelerated corrosion studies.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mowry, Curtis Dale; Glass, Sarah Jill; Sorensen, Neil Robert

2011-03-01

Sandia National Laboratories (SNL) conducted accelerated atmospheric corrosion testing for the U.S. Consumer Product Safety Commission (CPSC) to help further the understanding of the development of corrosion products on conductor materials in household electrical components exposed to environmental conditions representative of homes constructed with problem drywall. The conditions of the accelerated testing were chosen to produce corrosion product growth that would be consistent with long-term exposure to environments containing humidity and parts per billion (ppb) levels of hydrogen sulfide (H{sub 2}S) that are thought to have been the source of corrosion in electrical components from affected homes. This report documentsmore » the test set-up, monitoring of electrical performance of powered electrical components during the exposure, and the materials characterization conducted on wires, screws, and contact plates from selected electrical components. No degradation in electrical performance (measured via voltage drop) was measured during the course of the 8-week exposure, which was approximately equivalent to 40 years of exposure in a light industrial environment. Analyses show that corrosion products consisting of various phases of copper sulfide, copper sulfate, and copper oxide are found on exposed surfaces of the conductor materials including wires, screws, and contact plates. The morphology and the thickness of the corrosion products showed a range of character. In some of the copper wires that were observed, corrosion product had flaked or spalled off the surface, exposing fresh metal to the reaction with the contaminant gasses; however, there was no significant change in the wire cross-sectional area.« less

Analytical stability and simulation response study for a coupled two-body system

NASA Technical Reports Server (NTRS)

Tao, K. M.; Roberts, J. R.

1975-01-01

An analytical stability study and a digital simulation response study of two connected rigid bodies are documented. Relative rotation of the bodies at the connection is allowed, thereby providing a model suitable for studying system stability and response during a soft-dock regime. Provisions are made of a docking port axes alignment torque and a despin torque capability for encountering spinning payloads. Although the stability analysis is based on linearized equations, the digital simulation is based on nonlinear models.

Accelerator Science: Proton vs. Electron

ScienceCinema

Lincoln, Don

2018-06-12

Particle accelerators are one of the most powerful ways to study the fundamental laws that govern the universe. However, there are many design considerations that go into selecting and building a particular accelerator. In this video, Fermilab’s Dr. Don Lincoln explains the pros and cons of building an accelerator that collides pairs of protons to one that collides electrons.

Accelerator Science: Proton vs. Electron

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lincoln, Don

Particle accelerators are one of the most powerful ways to study the fundamental laws that govern the universe. However, there are many design considerations that go into selecting and building a particular accelerator. In this video, Fermilab’s Dr. Don Lincoln explains the pros and cons of building an accelerator that collides pairs of protons to one that collides electrons.

Community Petascale Project for Accelerator Science and Simulation: Advancing Computational Science for Future Accelerators and Accelerator Technologies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Spentzouris, P.; /Fermilab; Cary, J.

The design and performance optimization of particle accelerators are essential for the success of the DOE scientific program in the next decade. Particle accelerators are very complex systems whose accurate description involves a large number of degrees of freedom and requires the inclusion of many physics processes. Building on the success of the SciDAC-1 Accelerator Science and Technology project, the SciDAC-2 Community Petascale Project for Accelerator Science and Simulation (ComPASS) is developing a comprehensive set of interoperable components for beam dynamics, electromagnetics, electron cooling, and laser/plasma acceleration modelling. ComPASS is providing accelerator scientists the tools required to enable the necessarymore » accelerator simulation paradigm shift from high-fidelity single physics process modeling (covered under SciDAC1) to high-fidelity multiphysics modeling. Our computational frameworks have been used to model the behavior of a large number of accelerators and accelerator R&D experiments, assisting both their design and performance optimization. As parallel computational applications, the ComPASS codes have been shown to make effective use of thousands of processors. ComPASS is in the first year of executing its plan to develop the next-generation HPC accelerator modeling tools. ComPASS aims to develop an integrated simulation environment that will utilize existing and new accelerator physics modules with petascale capabilities, by employing modern computing and solver technologies. The ComPASS vision is to deliver to accelerator scientists a virtual accelerator and virtual prototyping modeling environment, with the necessary multiphysics, multiscale capabilities. The plan for this development includes delivering accelerator modeling applications appropriate for each stage of the ComPASS software evolution. Such applications are already being used to address challenging problems in accelerator design and optimization. The Com

Accelerated aging, natural aging, and small punch testing of gamma-air sterilized polycarbonate urethane acetabular components.

PubMed

Kurtz, S M; Siskey, R; Reitman, M

2010-05-01

The objectives of this study were three-fold: (1) to determine the applicability of the small punch test to characterize Bionate 80A polycarbonate urethane (PCU) acetabular implants; (2) to evaluate the susceptibility of PCU acetabular implants to exhibit degradation of mechanical behavior following gamma irradiation in air and accelerated aging; and (3) to compare the oxidation of gamma-air sterilized PCU following accelerated aging and 5 years of natural shelf aging. In addition to attenuated total reflectance-Fourier transform infrared spectroscopy, we also adapted a miniature specimen mechanical test, the small punch test, for the deformable PCU cups. Accelerated aging was performed using ASTM F2003, a standard test that represents a severe oxidative challenge. The results of this study suggest that the small punch test is sufficiently sensitive and reproducible to discriminate slight differences in the large-deformation mechanical behavior of Bionate 80A following accelerated aging. The gamma-air sterilized PCU had a reduction of 9% in ultimate load after aging. Five years of shelf aging had little effect on the mechanical properties of the PCU. Overall, our findings suggest that the Bionate 80A material has greater oxidative stability than ultra-high molecular weight polyethylene following gamma irradiation in air and exposure to a severe oxidative challenge. (c) 2010 Wiley Periodicals, Inc.

Small-scale laser based electron accelerators for biology and medicine: a comparative study of the biological effectiveness

NASA Astrophysics Data System (ADS)

Labate, Luca; Andreassi, Maria Grazia; Baffigi, Federica; Basta, Giuseppina; Bizzarri, Ranieri; Borghini, Andrea; Candiano, Giuliana C.; Casarino, Carlo; Cresci, Monica; Di Martino, Fabio; Fulgentini, Lorenzo; Ghetti, Francesco; Gilardi, Maria Carla; Giulietti, Antonio; Köster, Petra; Lenci, Francesco; Levato, Tadzio; Oishi, Yuji; Russo, Giorgio; Sgarbossa, Antonella; Traino, Claudio; Gizzi, Leonida A.

2013-05-01

Laser-driven electron accelerators based on the Laser Wakefield Acceleration process has entered a mature phase to be considered as alternative devices to conventional radiofrequency linear accelerators used in medical applications. Before entering the medical practice, however, deep studies of the radiobiological effects of such short bunches as the ones produced by laser-driven accelerators have to be performed. Here we report on the setup, characterization and first test of a small-scale laser accelerator for radiobiology experiments. A brief description of the experimental setup will be given at first, followed by an overview of the electron bunch characterization, in particular in terms of dose delivered to the samples. Finally, the first results from the irradiation of biological samples will be briefly discussed.

Computational screening of organic polymer dielectrics for novel accelerator technologies

DOE PAGES

Pilania, Ghanshyam; Weis, Eric; Walker, Ethan M.; ...

2018-06-18

The use of infrared lasers to power accelerating dielectric structures is a developing area of research. Within this technology, the choice of the dielectric material forming the accelerating structures, such as the photonic band gap (PBG) structures, is dictated by a range of interrelated factors including their dielectric and optical properties, amenability to photo-polymerization, thermochemical stability and other target performance metrics of the particle accelerator. In this direction, electronic structure theory aided computational screening and design of dielectric materials can play a key role in identifying potential candidate materials with the targeted functionalities to guide experimental synthetic efforts. In anmore » attempt to systematically understand the role of chemistry in controlling the electronic structure and dielectric properties of organic polymeric materials, here we employ empirical screening and density functional theory (DFT) computations, as a part of our multi-step hierarchal screening strategy. Our DFT based analysis focused on the bandgap, dielectric permittivity, and frequency-dependent dielectric losses due to lattice absorption as key properties to down-select promising polymer motifs. In addition to the specific application of dielectric laser acceleration, the general methodology presented here is deemed to be valuable in the design of new insulators with an attractive combination of dielectric properties.« less

High Gradient Accelerator Research

DOE Office of Scientific and Technical Information (OSTI.GOV)

Temkin, Richard

The goal of the MIT program of research on high gradient acceleration is the development of advanced acceleration concepts that lead to a practical and affordable next generation linear collider at the TeV energy level. Other applications, which are more near-term, include accelerators for materials processing; medicine; defense; mining; security; and inspection. The specific goals of the MIT program are: • Pioneering theoretical research on advanced structures for high gradient acceleration, including photonic structures and metamaterial structures; evaluation of the wakefields in these advanced structures • Experimental research to demonstrate the properties of advanced structures both in low-power microwave coldmore » test and high-power, high-gradient test at megawatt power levels • Experimental research on microwave breakdown at high gradient including studies of breakdown phenomena induced by RF electric fields and RF magnetic fields; development of new diagnostics of the breakdown process • Theoretical research on the physics and engineering features of RF vacuum breakdown • Maintaining and improving the Haimson / MIT 17 GHz accelerator, the highest frequency operational accelerator in the world, a unique facility for accelerator research • Providing the Haimson / MIT 17 GHz accelerator facility as a facility for outside users • Active participation in the US DOE program of High Gradient Collaboration, including joint work with SLAC and with Los Alamos National Laboratory; participation of MIT students in research at the national laboratories • Training the next generation of Ph. D. students in the field of accelerator physics.« less

Preparation and characterization of azithromycin--Aerosil 200 solid dispersions with enhanced physical stability.

PubMed

Li, Xuechao; Peng, Huanhuan; Tian, Bin; Gou, Jingxin; Yao, Qing; Tao, Xiaoguang; He, Haibing; Zhang, Yu; Tang, Xing; Cai, Cuifang

2015-01-01

The main purpose of this study was to investigate the feasibility of azithromycin (AZI)--Aerosil 200 solid dispersions specifically with high stability under accelerated condition (40 °C/75% RH). Ball milling (BM) and hot-melt extrusion (HME) were used to prepare AZI solid dispersions. The physical properties of solid dispersions were evaluated by differential scanning calorimetry (DSC), scanning electron microscopy (SEM), powder X-ray diffraction (PXRD), Fourier transform infrared spectroscopy (FT-IR) and thermogravimetric analysis (TGA). For solid dispersions prepared with both methods, no crystalline of AZI was detected (except for AZI: Aerosil 200=75:25) by DSC or PXRD, indicating the amorphous state of AZI in solid dispersions. The FT-IR results demonstrated the loss of crystallization water and the formation of hydrogen bonds between Aerosil 200 and AZI during the preparation of solid dispersions. After 4 weeks storage under accelerated condition, the degree of crystallinity of AZI increased in solid dispersions prepared by BM, whereas for solid dispersions containing AZI, Aerosil 200 and glyceryl behenate (GB) prepared by HME, no crystalline of AZI was identified. This high stability can be attributed to the hydrophobic properties of GB and the presence of hydrogen bonds. Based on the above results, it is inferred the protection of hydrogen bonds between AZI and Aerosil 200 formed during preparation process effectively inhibited the recrystallization of AZI and improved the physical stability of amorphous AZI in the presence of Aerosil 200. Copyright © 2015 Elsevier B.V. All rights reserved.

Imposed Faster and Slower Walking Speeds Influence Gait Stability Differently in Parkinson Fallers.

PubMed

Cole, Michael H; Sweeney, Matthew; Conway, Zachary J; Blackmore, Tim; Silburn, Peter A

2017-04-01

To evaluate the effect of imposed faster and slower walking speeds on postural stability in people with Parkinson disease (PD). Cross-sectional cohort study. General community. Patients with PD (n=84; 51 with a falls history; 33 without) and age-matched controls (n=82) were invited to participate via neurology clinics and preexisting databases. Of those contacted, 99 did not respond (PD=36; controls=63) and 27 were not interested (PD=18; controls=9). After screening, a further 10 patients were excluded; 5 had deep brain stimulation surgery and 5 could not accommodate to the treadmill. The remaining patients (N=30) completed all assessments and were subdivided into PD fallers (n=10), PD nonfallers (n=10), and age-matched controls (n=10) based on falls history. Not applicable. Three-dimensional accelerometers assessed head and trunk accelerations and allowed calculation of harmonic ratios and root mean square (RMS) accelerations to assess segment control and movement amplitude. Symptom severity, balance confidence, and medical history were established before participants walked on a treadmill at 70%, 100%, and 130% of their preferred speed. Head and trunk control was lower for PD fallers than PD nonfallers and older adults. Significant interactions indicated head and trunk control increased with speed for PD nonfallers and older adults, but did not improve at faster speeds for PD fallers. Vertical head and trunk accelerations increased with walking speed for PD nonfallers and older adults, while the PD fallers demonstrated greater anteroposterior RMS accelerations compared with both other groups. The results suggest that improved gait dynamics do not necessarily represent improved walking stability, and this must be respected when rehabilitating gait in patients with PD. Copyright © 2016 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.

Theory of unfolded cyclotron accelerator

NASA Astrophysics Data System (ADS)

Rax, J.-M.; Robiche, J.

2010-10-01

An acceleration process based on the interaction between an ion, a tapered periodic magnetic structure, and a circularly polarized oscillating electric field is identified and analyzed, and its potential is evaluated. A Hamiltonian analysis is developed in order to describe the interplay between the cyclotron motion, the electric acceleration, and the magnetic modulation. The parameters of this universal class of magnetic modulation leading to continuous acceleration without Larmor radius increase are expressed analytically. Thus, this study provides the basic scaling of what appears as a compact unfolded cyclotron accelerator.

Accelerated optical polymer aging studies for LED luminaire applications

NASA Astrophysics Data System (ADS)

Estupiñán, Edgar; Wendling, Peter; Kostrun, Marijan; Garner, Richard

2013-09-01

There is a need in the lighting industry to design and implement accelerated aging methods that accurately simulate the aging process of LED luminaire components. In response to this need, we have built a flexible and reliable system to study the aging characteristics of optical polymer materials, and we have employed it to study a commercially available LED luminaire diffuser made of PMMA. The experimental system consists of a "Blue LED Emitter" and a working surface. Both the temperatures of the samples and the optical powers of the LEDs are appropriately characterized in the system. Several accelerated aging experiments are carried out at different temperatures and optical powers over a 90 hour period and the measured transmission values are used as inputs to a degradation model derived using plausibility arguments. This model seems capable of predicting the behavior of the material as a function of time, temperature and optical power. The model satisfactorily predicts the measured transmission values of diffusers aged in luminaires at two different times and thus can be used to make application recommendations for this material. Specifically, at 35000 hours (the manufacturer's stated life of the luminaire) and at the typical operational temperature of the diffuser, the model predicts a transmission loss of only a few percent over the original transmission of the material at 450 nm, which renders this material suitable for this application.

Ballistocardiogaphic studies with acceleration and electromechanical film sensors.

PubMed

Alametsä, J; Värri, A; Viik, J; Hyttinen, J; Palomäki, A

2009-11-01

The purpose of this research is to demonstrate and compare the utilization of electromechanical film (EMFi) and two acceleration sensors, ADXL202 and MXA2500U, for ballistocardiographic (BCG) and pulse transit time (PTT) studies. We have constructed a mobile physiological measurement station including amplifiers and a data collection system to record the previously mentioned signals and an electrocardiogram signal. Various versions of the measuring systems used in BCG studies in the past are also presented and evaluated. We have showed the ability of the EMFi sensor to define the elastic properties of the cardiovascular system and to ensure the functionality of the proposed instrumentation in different physiological loading conditions, before and after exercise and sauna bath. The EMFi sensor provided a BCG signal of good quality in the study of the human heart and function of the cardiovascular system with different measurement configurations. EMFi BCG measurements provided accurate and repeatable results for the different components of the heart cycle. In multiple-channel EMFi measurements, the carotid and limb pulse signals acquired were detailed and distinctive, allowing accurate PTT measurements. Changes in blood pressure were clearly observed and easily determined with EMFi sensor strips in pulse wave velocity (PWV) measurements. In conclusion, the configuration of the constructed device provided reliable measurements of the electrocardiogram, BCG, heart sound, and carotid and ankle pulse wave signals. Attached EMFi sensor strips on the neck and limbs yield completely new applications of the EMFi sensors aside from the conventional seat and supine recordings. Higher sensitivity, ease of utilization, and minimum discomfort of the EMFi sensor compared with acceleration sensors strengthen the status of the EMFi sensor for accurate and reliable BCG and PWV measurements, providing novel evaluation of the elastic properties of the cardiovascular system.

Approaches to improve the stability of the antiviral agent UC781 in aqueous solutions.

PubMed

Damian, Festo; Fabian, Judit; Friend, David R; Kiser, Patrick F

2010-08-30

In this work, we evaluated the chemical stability profiles of UC781 based solutions to identify excipients that stabilize the microbicidal agent UC781. When different antioxidants were added to UC781 in sulfobutylether-beta-cyclodextrin (SBE-beta-CD) solutions and subjected to a 50 degrees C stability study, it was observed that EDTA was a better stabilizing agent than sodium metabisulfite, glutathione or ascorbic acid. Some antioxidants accelerated the degradation of UC781, suggesting metal-catalyzed degradation of UC781. Furthermore, we observed substantial degradation of UC781 when stored in 1% Tween 80 and 1% DMSO solutions alone or in those with 10mM EDTA. On the other hand, improved stability of UC781 in the presence of 100 and 200mM of EDTA was observed in these solutions. The addition of both EDTA and citric acid in the stock solutions resulted in recovery of more than 60% of UC781 after 12 weeks. Generally, 10% SBE-beta-CD in the presence of EDTA and citric acid stabilized UC781 solutions: the amount of UC781 recovered approaching 95% after 12 weeks of storage at 40 degrees C. We also showed that the desulfuration reaction of the UC781 thioamide involves oxygen by running solution stability studies in deoxygenated media. Improved stability of UC781 in the present study indicates that the incorporation of EDTA, citric acid and SBE-beta-CD and the removal of oxygen in formulations of this drug will aid in increasing the stability of UC781 where solutions of the drug are required. Published by Elsevier B.V.

Particle acceleration in pulsar magnetospheres

NASA Technical Reports Server (NTRS)

Baker, K. B.

1978-01-01

The structure of pulsar magnetospheres and the acceleration mechanism for charged particles in the magnetosphere was studied using a pulsar model which required large acceleration of the particles near the surface of the star. A theorem was developed which showed that particle acceleration cannot be expected when the angle between the magnetic field lines and the rotation axis is constant (e.g. radial field lines). If this angle is not constant, however, acceleration must occur. The more realistic model of an axisymmetric neutron star with a strong dipole magnetic field aligned with the rotation axis was investigated. In this case, acceleration occurred at large distances from the surface of the star. The magnitude of the current can be determined using the model presented. In the case of nonaxisymmetric systems, the acceleration is expected to occur nearer to the surface of the star.

Accelerators, Beams And Physical Review Special Topics - Accelerators And Beams

DOE Office of Scientific and Technical Information (OSTI.GOV)

Siemann, R.H.; /SLAC

Accelerator science and technology have evolved as accelerators became larger and important to a broad range of science. Physical Review Special Topics - Accelerators and Beams was established to serve the accelerator community as a timely, widely circulated, international journal covering the full breadth of accelerators and beams. The history of the journal and the innovations associated with it are reviewed.

Commnity Petascale Project for Accelerator Science And Simulation: Advancing Computational Science for Future Accelerators And Accelerator Technologies